                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  T CELL RECEPTORS RECOGNIZING R273C OR Y220C MUTATION IN P53

<130>  757042

<150>  US 63/074,747
<151>  2020-09-04

<160>  151   

<170>  PatentIn version 3.5

<210>  1
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  2
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Ser Ala Phe Gln Tyr 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Tyr Ser Ser Gly Asn 
1               5       


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Ala Gly Gly Ser Tyr Gly Lys Leu Thr Phe 
1               5                   10      


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asn His Glu Tyr 
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Met Asn Val Glu Val 
1               5       


<210>  7
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Ala Ser Ser Phe Ile Ser Asn Gln Pro Gln His Phe 
1               5                   10              


<210>  8
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu Ser Val Pro Glu 
1               5                   10                  15      


Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn Ser Ala Phe Gln 
            20                  25                  30          


Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly Pro Glu Leu Leu 
        35                  40                  45              


Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly Arg Phe Thr Ala 
    50                  55                  60                  


Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe Ile Arg Asp Ser 
65                  70                  75                  80  


Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Gly Gly Ser Tyr Gly 
                85                  90                  95      


Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro 
            100                 105                 110 


<210>  9
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys 
1               5                   10                  15      


Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met 
        35                  40                  45              


Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val 
    50                  55                  60                  


Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser 
65                  70                  75                  80  


Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Phe Ile Ser Asn 
                85                  90                  95      


Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
            100                 105                 110 


<210>  10
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met His Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Gly Gly Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr 
        115                 120                 125             


Val His Pro 
    130     


<210>  11
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Phe Ile Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
        115                 120                 125             


Ser Ile Leu 
    130     


<210>  12
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Gly Gly Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr 
        115                 120                 125             


Val His Pro 
    130     


<210>  13
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Phe Ile Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
        115                 120                 125             


Ser Ile Leu 
    130     


<210>  14
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met His Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Gly Gly Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  15
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Phe Ile Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
        115                 120                 125             


Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  16
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Gly Gly Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  17
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Phe Ile Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
        115                 120                 125             


Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  18
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu Ser Val Pro Glu 
1               5                   10                  15      


Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn Ser Ala Phe Gln 
            20                  25                  30          


Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly Pro Glu Leu Leu 
        35                  40                  45              


Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly Arg Phe Thr Ala 
    50                  55                  60                  


Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe Ile Arg Asp Ser 
65                  70                  75                  80  


Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Gly Gly Ser Tyr Gly 
                85                  90                  95      


Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
        115                 120                 125             


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
    130                 135                 140                 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
145                 150                 155                 160 


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
                165                 170                 175     


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
            180                 185                 190         


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
        195                 200                 205             


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
    210                 215                 220                 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
225                 230                 235                 240 


Thr Leu Arg Leu Trp Ser Ser 
                245         


<210>  19
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys 
1               5                   10                  15      


Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met 
        35                  40                  45              


Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val 
    50                  55                  60                  


Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser 
65                  70                  75                  80  


Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Phe Ile Ser Asn 
                85                  90                  95      


Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp 
            100                 105                 110         


Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys 
        115                 120                 125             


Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg 
    130                 135                 140                 


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
145                 150                 155                 160 


Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser 
                165                 170                 175     


Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
            180                 185                 190         


Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly 
        195                 200                 205             


Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr 
    210                 215                 220                 


Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr 
225                 230                 235                 240 


Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
                245                 250                 255     


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu 
            260                 265                 270         


Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280             


<210>  20
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Phe Ile Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
        115                 120                 125             


Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
305                 310                 315                 320 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Lys Ser Leu 
                325                 330                 335     


Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser Trp Val Trp Ser 
            340                 345                 350         


Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu Ser Val Pro Glu 
        355                 360                 365             


Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn Ser Ala Phe Gln 
    370                 375                 380                 


Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly Pro Glu Leu Leu 
385                 390                 395                 400 


Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly Arg Phe Thr Ala 
                405                 410                 415     


Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe Ile Arg Asp Ser 
            420                 425                 430         


Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Gly Gly Ser Tyr Gly 
        435                 440                 445             


Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile 
    450                 455                 460                 


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
465                 470                 475                 480 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
                485                 490                 495     


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
            500                 505                 510         


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
        515                 520                 525             


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
    530                 535                 540                 


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
545                 550                 555                 560 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
                565                 570                 575     


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
            580                 585                 590         


Thr Leu Arg Leu Trp Ser Ser 
        595                 


<210>  21
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  21

Asn Ser Ala Ser Asp Tyr 
1               5       


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Arg Ser Asn Met Asp Lys 
1               5           


<210>  23
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  23

Cys Ala Glu Lys Ser Thr Gly Asn Gln Phe Tyr Phe 
1               5                   10          


<210>  24
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Gly His Asn Ala 
1               5   


<210>  25
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  25

Tyr Ser Leu Glu Glu Arg 
1               5       


<210>  26
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  26

Cys Ala Ser Ser Arg Val Glu Gly Ser Asp Thr Gln Tyr Phe 
1               5                   10                  


<210>  27
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly Asp 
1               5                   10                  15      


Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr Phe 
            20                  25                  30          


Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp 
        35                  40                  45              


Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val Leu 
    50                  55                  60                  


Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr Gln 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Lys Ser Thr Gly Asn 
                85                  90                  95      


Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro 
            100                 105                 110 


<210>  28
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met Gly Met 
1               5                   10                  15      


Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His Asn Ala 
            20                  25                  30          


Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu Met Phe 
        35                  40                  45              


Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His Leu His 
65                  70                  75                  80  


Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Arg 
                85                  90                  95      


Val Glu Gly Ser Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Leu 
        


<210>  29
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Met His Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Ser Thr Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr 
        115                 120                 125             


Val Ile Pro 
    130     


<210>  30
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Met Ala Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Val Glu Gly Ser Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu 
    130         


<210>  31
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Ser Thr Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr 
        115                 120                 125             


Val Ile Pro 
    130     


<210>  32
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Val Glu Gly Ser Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu 
    130         


<210>  33
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Met His Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Ser Thr Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr 
        115                 120                 125             


Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  34
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Met Ala Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Val Glu Gly Ser Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  35
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Ser Thr Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr 
        115                 120                 125             


Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  36
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Val Glu Gly Ser Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  37
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly Asp 
1               5                   10                  15      


Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr Phe 
            20                  25                  30          


Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp 
        35                  40                  45              


Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val Leu 
    50                  55                  60                  


Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr Gln 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Lys Ser Thr Gly Asn 
                85                  90                  95      


Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro Asn Ile 
            100                 105                 110         


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
        115                 120                 125             


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
    130                 135                 140                 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
145                 150                 155                 160 


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
                165                 170                 175     


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
            180                 185                 190         


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
        195                 200                 205             


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
    210                 215                 220                 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
225                 230                 235                 240 


Thr Leu Arg Leu Trp Ser Ser 
                245         


<210>  38
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met Gly Met 
1               5                   10                  15      


Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His Asn Ala 
            20                  25                  30          


Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu Met Phe 
        35                  40                  45              


Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His Leu His 
65                  70                  75                  80  


Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Arg 
                85                  90                  95      


Val Glu Gly Ser Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
        115                 120                 125             


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
                165                 170                 175     


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        195                 200                 205             


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
    210                 215                 220                 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
225                 230                 235                 240 


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                245                 250                 255     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            260                 265                 270         


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285         


<210>  39
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Met Ala Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Val Glu Gly Ser Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Gly Ile 
                325                 330                 335     


Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp Trp Val Ser Arg 
            340                 345                 350         


Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly 
        355                 360                 365             


Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr 
    370                 375                 380                 


Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile 
385                 390                 395                 400 


Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val 
                405                 410                 415     


Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr 
            420                 425                 430         


Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Lys Ser Thr Gly 
        435                 440                 445             


Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro Asn 
    450                 455                 460                 


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
465                 470                 475                 480 


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
                485                 490                 495     


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
            500                 505                 510         


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
        515                 520                 525             


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
    530                 535                 540                 


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
545                 550                 555                 560 


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val 
                565                 570                 575     


Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
            580                 585                 590         


Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600 


<210>  40
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  40

Val Ser Gly Asn Pro Tyr 
1               5       


<210>  41
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  41

Tyr Ile Thr Gly Asp Asn Leu Val 
1               5               


<210>  42
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  42

Cys Ala Val Arg Asp Pro Thr Val Ser Gly Thr Tyr Lys Tyr Ile Phe 
1               5                   10                  15      


<210>  43
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  43

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  44
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  45
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  45

Cys Ser Ala Ile Arg Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  46
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly Asn 
1               5                   10                  15      


Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr Leu 
            20                  25                  30          


Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu Lys 
        35                  40                  45              


Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu Ala 
    50                  55                  60                  


Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser Ala 
65                  70                  75                  80  


Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Pro Thr 
                85                  90                  95      


Val Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys 
            100                 105                 110         


Val Leu Ala 
        115 


<210>  47
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ile 
                85                  90                  95      


Arg Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Leu Val Leu 
        115     


<210>  48
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Met His Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Pro Thr Val Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly 
        115                 120                 125             


Thr Arg Leu Lys Val Leu Ala 
    130                 135 


<210>  49
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ile Arg 
            100                 105                 110         


Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu 
    130     


<210>  50
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Pro Thr Val Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly 
        115                 120                 125             


Thr Arg Leu Lys Val Leu Ala 
    130                 135 


<210>  51
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ile Arg 
            100                 105                 110         


Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu 
    130     


<210>  52
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met His Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Pro Thr Val Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly 
        115                 120                 125             


Thr Arg Leu Lys Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  53
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ile Arg 
            100                 105                 110         


Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  54
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Pro Thr Val Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly 
        115                 120                 125             


Thr Arg Leu Lys Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  55
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ile Arg 
            100                 105                 110         


Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  56
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly Asn 
1               5                   10                  15      


Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr Leu 
            20                  25                  30          


Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu Lys 
        35                  40                  45              


Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu Ala 
    50                  55                  60                  


Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser Ala 
65                  70                  75                  80  


Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Pro Thr 
                85                  90                  95      


Val Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys 
            100                 105                 110         


Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
        115                 120                 125             


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
    130                 135                 140                 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
145                 150                 155                 160 


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
                165                 170                 175     


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
            180                 185                 190         


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
        195                 200                 205             


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
    210                 215                 220                 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
225                 230                 235                 240 


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250         


<210>  57
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Ala Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ile 
                85                  90                  95      


Arg Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
            100                 105                 110         


Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
        115                 120                 125             


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
                165                 170                 175     


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
    210                 215                 220                 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
                245                 250                 255     


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
            260                 265                 270         


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
        275                 280                 285             


Ser 
    


<210>  58
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ile Arg 
            100                 105                 110         


Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
305                 310                 315                 320 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Ser Ala Pro 
                325                 330                 335     


Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser Gly Leu Arg Ala Gln 
            340                 345                 350         


Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly Asn Pro 
        355                 360                 365             


Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr Leu Phe 
    370                 375                 380                 


Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu Lys Tyr 
385                 390                 395                 400 


Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu Ala Glu 
                405                 410                 415     


Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser Ala Leu 
            420                 425                 430         


Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Pro Thr Val 
        435                 440                 445             


Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys Val 
    450                 455                 460                 


Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
465                 470                 475                 480 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
                485                 490                 495     


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
            500                 505                 510         


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
        515                 520                 525             


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
    530                 535                 540                 


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
545                 550                 555                 560 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
                565                 570                 575     


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
            580                 585                 590         


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600             


<210>  59
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  59

Asn Thr Ala Phe Asp Tyr 
1               5       


<210>  60
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  60

Ile Arg Pro Asp Val Ser Glu 
1               5           


<210>  61
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  61

Cys Ala Ala Lys Arg Gln Gly Gly Ser Glu Lys Leu Val Phe 
1               5                   10                  


<210>  62
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  62

Ser Gly His Thr Ala 
1               5   


<210>  63
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  63

Phe Gln Gly Asn Ser Ala 
1               5       


<210>  64
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  64

Cys Ala Ser Ser Leu Gly Gly Ser Ser Glu Thr Gln Tyr Phe 
1               5                   10                  


<210>  65
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  65

Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val Lys Gln Ser Pro Gln 
1               5                   10                  15      


Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile Ile Asn Cys Ala Tyr 
            20                  25                  30          


Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr Gln Gln Phe Pro Gly 
        35                  40                  45              


Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro Asp Val Ser Glu Lys 
    50                  55                  60                  


Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys Ser Ala Lys Gln Phe 
65                  70                  75                  80  


Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp Ser Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Ala Lys Arg Gln Gly Gly Ser Glu Lys Leu Val Phe Gly Lys 
            100                 105                 110         


Gly Thr Lys Leu Thr Val Asn Pro 
        115                 120 


<210>  66
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Asp 
1               5                   10                  15      


Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe Leu Ile Tyr Phe Gln 
        35                  40                  45              


Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro Ser Asp Arg Phe Ser 
    50                  55                  60                  


Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu Thr Ile Gln Arg Thr 
65                  70                  75                  80  


Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu Gly Gly 
                85                  90                  95      


Ser Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu 
            100                 105                 110         


<210>  67
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Met His Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Lys Arg Gln Gly Gly Ser Glu Lys 
        115                 120                 125             


Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro 
    130                 135                 140     


<210>  68
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Met Ala Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Gly Ser Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu 
    130             


<210>  69
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Asp Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Lys Arg Gln Gly Gly Ser Glu Lys 
        115                 120                 125             


Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro 
    130                 135                 140     


<210>  70
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Gly Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Gly Ser Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu 
    130             


<210>  71
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Met His Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Lys Arg Gln Gly Gly Ser Glu Lys 
        115                 120                 125             


Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro Asn Ile Gln 
    130                 135                 140                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
145                 150                 155                 160 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                165                 170                 175     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
            180                 185                 190         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        195                 200                 205             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    210                 215                 220                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
225                 230                 235                 240 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
                245                 250                 255     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            260                 265                 270         


Leu Arg Leu Trp Ser Ser 
        275             


<210>  72
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Met Ala Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Gly Ser Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  73
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Met Asp Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Lys Arg Gln Gly Gly Ser Glu Lys 
        115                 120                 125             


Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro Asn Ile Gln 
    130                 135                 140                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
145                 150                 155                 160 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                165                 170                 175     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
            180                 185                 190         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        195                 200                 205             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    210                 215                 220                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
225                 230                 235                 240 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
                245                 250                 255     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            260                 265                 270         


Leu Arg Leu Trp Ser Ser 
        275             


<210>  74
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Met Gly Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Gly Ser Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  75
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val Lys Gln Ser Pro Gln 
1               5                   10                  15      


Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile Ile Asn Cys Ala Tyr 
            20                  25                  30          


Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr Gln Gln Phe Pro Gly 
        35                  40                  45              


Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro Asp Val Ser Glu Lys 
    50                  55                  60                  


Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys Ser Ala Lys Gln Phe 
65                  70                  75                  80  


Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp Ser Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Ala Lys Arg Gln Gly Gly Ser Glu Lys Leu Val Phe Gly Lys 
            100                 105                 110         


Gly Thr Lys Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala 
        115                 120                 125             


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
    130                 135                 140                 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
145                 150                 155                 160 


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
                165                 170                 175     


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
            180                 185                 190         


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
        195                 200                 205             


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
    210                 215                 220                 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
225                 230                 235                 240 


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
                245                 250                 255     


Ser 
    


<210>  76
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Asp 
1               5                   10                  15      


Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe Leu Ile Tyr Phe Gln 
        35                  40                  45              


Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro Ser Asp Arg Phe Ser 
    50                  55                  60                  


Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu Thr Ile Gln Arg Thr 
65                  70                  75                  80  


Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu Gly Gly 
                85                  90                  95      


Ser Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu 
            100                 105                 110         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        115                 120                 125             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                165                 170                 175     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            180                 185                 190         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        195                 200                 205             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    210                 215                 220                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
225                 230                 235                 240 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                245                 250                 255     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            260                 265                 270         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285 


<210>  77
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Met Ala Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Gly Ser Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
305                 310                 315                 320 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Lys 
                325                 330                 335     


Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu Cys Trp Val 
            340                 345                 350         


Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val Lys Gln Ser 
        355                 360                 365             


Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile Ile Asn Cys 
    370                 375                 380                 


Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr Gln Gln Phe 
385                 390                 395                 400 


Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro Asp Val Ser 
                405                 410                 415     


Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys Ser Ala Lys 
            420                 425                 430         


Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp Ser Ala Thr 
        435                 440                 445             


Tyr Phe Cys Ala Ala Lys Arg Gln Gly Gly Ser Glu Lys Leu Val Phe 
    450                 455                 460                 


Gly Lys Gly Thr Lys Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu 
465                 470                 475                 480 


Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu 
                485                 490                 495     


Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met 
            500                 505                 510         


Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala 
        515                 520                 525             


Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser 
    530                 535                 540                 


Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser 
545                 550                 555                 560 


Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr 
                565                 570                 575     


Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile 
            580                 585                 590         


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
        595                 600                 605             


Trp Ser Ser 
    610     


<210>  78
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  78

Asn Ser Ala Ser Asp Tyr 
1               5       


<210>  79
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  79

Ile Arg Ser Asn Met Asp Lys 
1               5           


<210>  80
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  80

Cys Ala Glu Lys Arg Arg Gly Gly Ser Glu Lys Leu Val Phe 
1               5                   10                  


<210>  81
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  81

Ser Gly His Thr Ala 
1               5   


<210>  82
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  82

Phe Gln Gly Thr Gly Ala 
1               5       


<210>  83
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  83

Cys Ala Ser Ser Pro Gly Gly Ser Gln Glu Thr Gln Tyr Phe 
1               5                   10                  


<210>  84
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  84

Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly Asp 
1               5                   10                  15      


Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr Phe 
            20                  25                  30          


Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp 
        35                  40                  45              


Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val Leu 
    50                  55                  60                  


Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr Gln 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Lys Arg Arg Gly Gly 
                85                  90                  95      


Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro 
            100                 105                 110         


<210>  85
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  85

Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Tyr 
1               5                   10                  15      


Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr Phe Gln 
        35                  40                  45              


Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg Phe Phe 
    50                  55                  60                  


Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu Lys Ile Gln Arg Thr 
65                  70                  75                  80  


Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Pro Gly Gly 
                85                  90                  95      


Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu 
            100                 105                 110         


<210>  86
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86

Met His Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Arg Arg Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Asn Pro 
    130             


<210>  87
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Gly Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu 
    130             


<210>  88
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Arg Arg Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Asn Pro 
    130             


<210>  89
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Gly Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu 
    130             


<210>  90
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90

Met His Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Arg Arg Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  91
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Gly Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  92
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Arg Arg Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  93
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93

Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Gly Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  94
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94

Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly Asp 
1               5                   10                  15      


Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr Phe 
            20                  25                  30          


Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp 
        35                  40                  45              


Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val Leu 
    50                  55                  60                  


Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr Gln 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Lys Arg Arg Gly Gly 
                85                  90                  95      


Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro 
            100                 105                 110         


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
        115                 120                 125             


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
    130                 135                 140                 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
145                 150                 155                 160 


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
                165                 170                 175     


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
            180                 185                 190         


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
        195                 200                 205             


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
    210                 215                 220                 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
225                 230                 235                 240 


Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 


<210>  95
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95

Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Tyr 
1               5                   10                  15      


Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr Phe Gln 
        35                  40                  45              


Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg Phe Phe 
    50                  55                  60                  


Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu Lys Ile Gln Arg Thr 
65                  70                  75                  80  


Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Pro Gly Gly 
                85                  90                  95      


Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu 
            100                 105                 110         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        115                 120                 125             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                165                 170                 175     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            180                 185                 190         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        195                 200                 205             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    210                 215                 220                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
225                 230                 235                 240 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                245                 250                 255     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            260                 265                 270         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285 


<210>  96
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Gly Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
305                 310                 315                 320 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Gly 
                325                 330                 335     


Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp Trp Val Ser 
            340                 345                 350         


Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu 
        355                 360                 365             


Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp 
    370                 375                 380                 


Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile 
385                 390                 395                 400 


Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr 
                405                 410                 415     


Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala 
            420                 425                 430         


Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Lys Arg Arg 
        435                 440                 445             


Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val 
    450                 455                 460                 


Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
465                 470                 475                 480 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
                485                 490                 495     


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
            500                 505                 510         


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
        515                 520                 525             


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
    530                 535                 540                 


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
545                 550                 555                 560 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
                565                 570                 575     


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
            580                 585                 590         


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600             


<210>  97
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  98
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  99
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  100
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  101
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 
                325                 330                 335     


Gln Lys Glu Asn Cys 
            340     


<210>  102
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu 
                325                 330                 335     


Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 
            340                 345     


<210>  103
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 
    290                 295                 300                 


Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 
305                 310                 315                 320 


Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys Lys Gly Gln 
                325                 330                 335     


Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu Gly Pro Asp 
            340                 345                 350         


Ser Asp 
        


<210>  104
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn Cys 
    290                 295                 300         


<210>  105
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr Phe Leu Ile 
    290                 295                 300                 


Asn Ser Ser 
305         


<210>  106
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met 
        195                 200                 205             


Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly 
    210                 215                 220                 


Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys 
225                 230                 235                 240 


Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 
                245                 250                 255     


Gly Pro Asp Ser Asp 
            260     


<210>  107
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 
        195                 200                 205             


Cys 
    


<210>  108
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr 
        195                 200                 205             


Phe Leu Ile Asn Ser Ser 
    210                 


<210>  109
<211>  1797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109
atggcgcccc agctgctggg ctacgtggtg ctgtgcctgc tgggagcagg accactggag       60

gcacaggtga cccagaaccc cagatatctg atcaccgtga caggcaagaa gctgaccgtg      120

acatgttccc agaacatgaa tcacgagtac atgtcttggt ataggcagga ccctggcctg      180

ggcctgaggc agatctacta ttctatgaat gtggaggtga cagacaaggg cgatgtgcct      240

gagggctaca aggtgagccg gaaggagaag agaaacttcc cactgatcct ggagtctccc      300

agccctaatc agaccagcct gtatttctgc gccagctcct ttatctccaa ccagccccag      360

cactttggcg atggcacaag gctgtccatc ctggaggatc tccggaatgt gacaccccct      420

aaggtgtctc tgttcgagcc aagcaaggcc gagatcgcca acaagcagaa ggccaccctg      480

gtgtgcctgg ccagaggctt ctttcccgat cacgtggagc tgtcctggtg ggtgaatggc      540

aaggaggtgc actctggcgt gtgcaccgac cctcaggcct ataaggagtc caactactct      600

tattgtctga gctcccggct gagagtgtcc gccacattct ggcacaatcc cagaaaccac      660

ttcagatgcc aggtgcagtt tcacggcctg tccgaggagg ataagtggcc tgagggctct      720

ccaaagcccg tgacccagaa tatcagcgcc gaggcatggg gaagggcaga ctgtggaatc      780

acctccgcct cttaccagca gggcgtgctg agcgccacaa tcctgtatga gatcctgctg      840

ggcaaggcca ccctgtacgc cgtgctggtg agcacactgg tggtcatggc tatggtgaag      900

aggaagaaca gccgggccaa gcgcagcggc tccggcgcaa ccaacttctc tctgctgaag      960

caggcaggcg acgtggagga gaatcctggc ccaatgcata agagcctgcg ggtgctgctg     1020

gtcatcctgt ggctccagct gtcttgggtg tggagccagc agaaggaggt ggagcaggac     1080

cccggccctc tgagcgtgcc tgagggagcc atcgtgtccc tgaactgcac ctactccaat     1140

tctgccttcc agtacttcat gtggtacagg cagtacagcc ggaagggccc cgagctgctg     1200

atgtacacct atagctccgg caacaaggag gacggcaggt tcacagccca ggtggataag     1260

tctagcaagt acatctccct gtttatccgc gactctcagc caagcgattc cgccacctac     1320

ctgtgcgcag gaggatccta tggcaagctg acattcggcc agggcaccat cctgacagtg     1380

caccccaata ttcagaatcc cgagcccgcg gtataccagc tgaaggaccc ccggagccag     1440

gatagcaccc tgtgcctgtt cacagacttt gattctcaga tcaacgtgcc caagacaatg     1500

gagagcggca cctttatcac agacaagtgc gtgctggaca tgaaggctat ggactctaag     1560

agcaatggcg ccatcgcctg gtccaaccag acctctttca catgccagga tatctttaag     1620

gagacaaatg ccacataccc cagctccgac gtgccttgtg atgccaccct gacagagaag     1680

agcttcgaga cagacatgaa tctgaacttt cagaacctgc tggtcatcgt gctgagaatc     1740

ctgctgctga aagtggctgg cttcaacctg ctgatgaccc tgcggctgtg gagtagc        1797


<210>  110
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110
atggcgtgcc ggctgctgtg ctgtgccgtg ctgtgcctgc tgggagcagt gccaatggag       60

accggagtga cccagacacc caggcacctg gtcatgggca tgacaaacaa gaagtctctg      120

aagtgcgagc agcacctggg ccacaatgcc atgtactggt ataagcagtc cgccaagaag      180

cctctggagc tgatgttcgt gtactctctg gaggagcggg tggagaacaa ttccgtgcca      240

agccggttca gccccgagtg ccctaacagc tcccacctgt ttctgcacct gcacaccctc      300

cagccagagg acagcgccct gtacctgtgc gcctctagca gggtggaggg ctccgataca      360

cagtattttg gccctggcac ccgcctgaca gtgctggagg atctccggaa tgtgacaccc      420

cctaaggtgt ctctgttcga gccaagcaag gccgagatcg ccaacaagca gaaggccacc      480

ctggtgtgcc tggccagagg cttctttccc gatcacgtgg agctgtcctg gtgggtgaat      540

ggcaaggagg tgcactctgg cgtgtgcacc gaccctcagg cctataagga gtccaactac      600

tcttattgtc tgagctcccg gctgagagtg tccgccacat tctggcacaa tcccagaaac      660

cacttcagat gccaggtgca gtttcacggc ctgtccgagg aggataagtg gcctgagggc      720

tctccaaagc ccgtgaccca gaatatcagc gccgaggcat ggggaagggc agactgtgga      780

atcacctccg cctcttacca gcagggcgtg ctgagcgcca caatcctgta tgagatcctg      840

ctgggcaagg ccaccctgta cgccgtgctg gtgagcacac tggtggtcat ggctatggtg      900

aagaggaaga acagccgggc caagcgcagc ggctccggcg caaccaactt ctctctgctg      960

aagcaggcag gcgacgtgga ggagaatcct ggcccaatgc atggcatcag ggccctgttc     1020

atgtacctgt ggctccagct ggactgggtg agccggggcg agtccgtggg actgcacctg     1080

ccaaccctgt ctgtgcagga gggcgacaac agcatcatca attgcgccta tagcaactcc     1140

gcctctgatt acttcatctg gtataagcag gagagcggca agggccccca gtttatcatc     1200

gacatccggt ccaacatgga taagcggcag ggccagagag tgaccgtgct gctgaataag     1260

acagtgaagc acctgtctct ccagatcgca gcaacacagc ccggcgattc cgccgtgtac     1320

ttttgtgccg agaagtctac cggcaatcag ttctattttg gcaccggcac aagcctgaca     1380

gtgatcccta atattcagaa tcccgagccc gcggtatacc agctgaagga cccccggagc     1440

caggatagca ccctgtgcct gttcacagac tttgattctc agatcaacgt gcccaagaca     1500

atggagagcg gcacctttat cacagacaag tgcgtgctgg acatgaaggc tatggactct     1560

aagagcaatg gcgccatcgc ctggtccaac cagacctctt tcacatgcca ggatatcttt     1620

aaggagacaa atgccacata ccccagctcc gacgtgcctt gtgatgccac cctgacagag     1680

aagagcttcg agacagacat gaatctgaac tttcagaacc tgctggtcat cgtgctgaga     1740

atcctgctgc tgaaagtggc tggcttcaac ctgctgatga ccctgcggct gtggagtagc     1800


<210>  111
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111
atggcgctgc tgctgctgct gctgggccct ggctctggcc tgggagcagt ggtgtcccag       60

caccctagca gagtgatctg caagtctggc acaagcgtga agatcgagtg taggagcctg      120

gacttccagg ccaccacaat gttctggtac cgccagtttc ccaagcagtc cctgatgctg      180

atggccacaa gcaacgaggg ctccaaggcc acctatgagc agggcgtgga gaaggataag      240

tttctgatca atcacgcctc tctgaccctg agcaccctga cagtgacctc cgcccaccca      300

gaggacagct ccttctacat ctgctccgcc atccgggata gatctggcgg cgagacacag      360

tattttggcc ctggcaccag gctgctggtg ctggaggatc tccggaatgt gacaccccct      420

aaggtgtctc tgttcgagcc aagcaaggcc gagatcgcca acaagcagaa ggccaccctg      480

gtgtgcctgg ccagaggctt ctttcccgat cacgtggagc tgtcctggtg ggtgaatggc      540

aaggaggtgc actctggcgt gtgcaccgac cctcaggcct ataaggagtc caactactct      600

tattgtctga gctcccggct gagagtgtcc gccacattct ggcacaatcc cagaaaccac      660

ttcagatgcc aggtgcagtt tcacggcctg tccgaggagg ataagtggcc tgagggctct      720

ccaaagcccg tgacccagaa tatcagcgcc gaggcatggg gaagggcaga ctgtggaatc      780

acctccgcct cttaccagca gggcgtgctg agcgccacaa tcctgtatga gatcctgctg      840

ggcaaggcca ccctgtacgc cgtgctggtg agcacactgg tggtcatggc tatggtgaag      900

aggaagaaca gccgggccaa gcgcagcggc tccggcgcaa ccaacttctc tctgctgaag      960

caggcaggcg acgtggagga gaatcctggc ccaatgcata gcgcccccat ctccatgctg     1020

gccatgctgt ttaccctgtc tggcctgagg gcacagagcg tggcacagcc agaggaccag     1080

gtgaacgtgg ccgagggcaa tcccctgacc gtgaagtgca catacagcgt gtccggcaac     1140

ccctatctgt tctggtacgt gcagtatcct aatcggggcc tccagttcct gctgaagtac     1200

atcaccggcg ataacctggt gaagggcagc tatggcttcg aggccgagtt taataagtcc     1260

cagacatctt tccacctgaa gaagccttcc gccctggtgt ctgacagcgc cctgtacttt     1320

tgtgccgtgc gggatccaac cgtgtctggc acatacaagt atatcttcgg caccggcaca     1380

agactgaagg tgctggccaa tattcagaat cccgagcccg cggtatacca gctgaaggac     1440

ccccggagcc aggatagcac cctgtgcctg ttcacagact ttgattctca gatcaacgtg     1500

cccaagacaa tggagagcgg cacctttatc acagacaagt gcgtgctgga catgaaggct     1560

atggactcta agagcaatgg cgccatcgcc tggtccaacc agacctcttt cacatgccag     1620

gatatcttta aggagacaaa tgccacatac cccagctccg acgtgccttg tgatgccacc     1680

ctgacagaga agagcttcga gacagacatg aatctgaact ttcagaacct gctggtcatc     1740

gtgctgagaa tcctgctgct gaaagtggct ggcttcaacc tgctgatgac cctgcggctg     1800

tggagtagc                                                             1809


<210>  112
<211>  1833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112
atggcgaccc ggctgctgtt ctgggtggca ttttgcctgc tgggagcaga ccacaccgga       60

gcaggcgtgt cccagtctcc aagcaacaag gtgacagaga agggcaagga cgtggagctg      120

aggtgtgatc ccatcagcgg ccacacagcc ctgtactggt ataggcagtc cctgggacag      180

ggcctggagt tcctgatcta ctttcagggc aattctgccc ccgacaagag cggcctgcct      240

tccgatcggt tctctgccga gagaaccggc ggctccgtgt ctaccctgac aatccagcgg      300

acacagcagg aggattccgc cgtgtacctg tgcgccagct ccctgggagg atctagcgag      360

acccagtatt ttggccctgg cacaaggctg ctggtgctgg aggatctccg gaatgtgaca      420

ccccctaagg tgtctctgtt cgagccaagc aaggccgaga tcgccaacaa gcagaaggcc      480

accctggtgt gcctggccag aggcttcttt cccgatcacg tggagctgtc ctggtgggtg      540

aatggcaagg aggtgcactc tggcgtgtgc accgaccctc aggcctataa ggagtccaac      600

tactcttatt gtctgagctc ccggctgaga gtgtccgcca cattctggca caatcccaga      660

aaccacttca gatgccaggt gcagtttcac ggcctgtccg aggaggataa gtggcctgag      720

ggctctccaa agcccgtgac ccagaatatc agcgccgagg catggggaag ggcagactgt      780

ggaatcacct ccgcctctta ccagcagggc gtgctgagcg ccacaatcct gtatgagatc      840

ctgctgggca aggccaccct gtacgccgtg ctggtgagca cactggtggt catggctatg      900

gtgaagagga agaacagccg ggccaagcgc agcggctccg gcgcaaccaa cttctctctg      960

ctgaagcagg caggcgacgt ggaggagaat cctggcccaa tgcataagat cctgggcgcc     1020

tccttcctgg tgctgtggct ccagctgtgc tgggtgagcg gccagcagaa ggagaagtcc     1080

gaccagcagc aggtgaagca gagcccccag tccctgatcg tgcagaaggg cggcatctct     1140

atcatcaact gtgcctacga gaataccgcc ttcgactact ttccctggta tcagcagttc     1200

cccggcaagg gacctgccct gctgatcgca atccggcccg acgtgagcga gaagaaggag     1260

ggcagattca ccatctcttt taacaagagc gccaagcagt ttagcctgca catcatggac     1320

tcccagcctg gcgattctgc cacatatttc tgcgcagcaa agaggcaggg aggaagcgag     1380

aagctggtgt ttggcaaggg caccaagctg acagtgaatc caaatattca gaatcccgag     1440

cccgcggtat accagctgaa ggacccccgg agccaggata gcaccctgtg cctgttcaca     1500

gactttgatt ctcagatcaa cgtgcccaag acaatggaga gcggcacctt tatcacagac     1560

aagtgcgtgc tggacatgaa ggctatggac tctaagagca atggcgccat cgcctggtcc     1620

aaccagacct ctttcacatg ccaggatatc tttaaggaga caaatgccac ataccccagc     1680

tccgacgtgc cttgtgatgc caccctgaca gagaagagct tcgagacaga catgaatctg     1740

aactttcaga acctgctggt catcgtgctg agaatcctgc tgctgaaagt ggctggcttc     1800

aacctgctga tgaccctgcg gctgtggagt agc                                  1833


<210>  113
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113
atggcgacca ggctgctgtg ctgggccgcc ctgtgcctgc tgggagcaga ccacacagga       60

gcaggcgtgt cccagacccc ttctaacaag gtgacagaga agggcaagta cgtggagctg      120

cggtgcgatc caatcagcgg ccacaccgcc ctgtactggt atagacagtc cctgggacag      180

ggccccgagt tcctgatcta ttttcaggga acaggagccg ccgacgattc cggcctgccc      240

aatgacaggt tctttgccgt gcgccctgag ggatctgtga gcaccctgaa gatccagcgg      300

acagagagag gcgatagcgc cgtgtacctg tgcgccagct ccccaggcgg aagccaggag      360

acccagtatt tcggccctgg cacaagactg ctggtgctgg aggatctccg gaatgtgaca      420

ccccctaagg tgtctctgtt cgagccaagc aaggccgaga tcgccaacaa gcagaaggcc      480

accctggtgt gcctggccag aggcttcttt cccgatcacg tggagctgtc ctggtgggtg      540

aatggcaagg aggtgcactc tggcgtgtgc accgaccctc aggcctataa ggagtccaac      600

tactcttatt gtctgagctc ccggctgaga gtgtccgcca cattctggca caatcccaga      660

aaccacttca gatgccaggt gcagtttcac ggcctgtccg aggaggataa gtggcctgag      720

ggctctccaa agcccgtgac ccagaatatc agcgccgagg catggggaag ggcagactgt      780

ggaatcacct ccgcctctta ccagcagggc gtgctgagcg ccacaatcct gtatgagatc      840

ctgctgggca aggccaccct gtacgccgtg ctggtgagca cactggtggt catggctatg      900

gtgaagagga agaacagccg ggccaagcgc agcggctccg gcgcaaccaa cttctctctg      960

ctgaagcagg caggcgacgt ggaggagaat cctggcccaa tgcatggcat ccgggccctg     1020

ttcatgtacc tgtggctcca gctggactgg gtgagcaggg gcgagtccgt gggactgcac     1080

ctgccaaccc tgtctgtgca ggagggcgac aacagcatca tcaattgcgc ctatagcaac     1140

tccgcctctg attacttcat ctggtataag caggagagcg gcaagggccc ccagtttatc     1200

atcgacatcc ggtccaacat ggataagagg cagggacaga gggtgaccgt gctgctgaat     1260

aagacagtga agcacctgtc cctccagatc gcagcaacac agcccggcga ttctgccgtg     1320

tacttctgtg ccgagaagcg gagaggcggc tctgagaagc tggtgtttgg caagggcacc     1380

aagctgacag tgaatcctaa tattcagaat cccgagcccg cggtatacca gctgaaggac     1440

ccccggagcc aggatagcac cctgtgcctg ttcacagact ttgattctca gatcaacgtg     1500

cccaagacaa tggagagcgg cacctttatc acagacaagt gcgtgctgga catgaaggct     1560

atggactcta agagcaatgg cgccatcgcc tggtccaacc agacctcttt cacatgccag     1620

gatatcttta aggagacaaa tgccacatac cccagctccg acgtgccttg tgatgccacc     1680

ctgacagaga agagcttcga gacagacatg aatctgaact ttcagaacct gctggtcatc     1740

gtgctgagaa tcctgctgct gaaagtggct ggcttcaacc tgctgatgac cctgcggctg     1800

tggagtagc                                                             1809


<210>  114
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  114

Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 
1               5                   10                  15      


Glu Val Gly Ser Asp Cys Thr Thr Ile 
            20                  25  


<210>  115
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  115

Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Cys Glu Pro Pro 
1               5                   10                  15      


Glu Val Gly Ser Asp Cys Thr Thr Ile 
            20                  25  


<210>  116
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  116

Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
1               5                   10                  15      


Cys Pro Gly Arg Asp Arg Arg Thr Glu 
            20                  25  


<210>  117
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  117

Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Cys Val Cys Ala 
1               5                   10                  15      


Cys Pro Gly Arg Asp Arg Arg Thr Glu 
            20                  25  


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  118

Arg Ala Lys Arg 
1               


<210>  119
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  119

Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn Ser Ala Phe Gln Tyr 
            20                  25                  30          


Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly Pro Glu Leu Leu Met 
        35                  40                  45              


Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Gly Gly Ser Tyr Gly Lys 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro 
            100                 105                 


<210>  120
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  120

Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly 
1               5                   10                  15      


Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr 
        35                  40                  45              


Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Phe Ile 
                85                  90                  95      


Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
            100                 105                 110         


<210>  121
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Gly Gly Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr 
        115                 120                 125             


Val His Pro 
    130     


<210>  122
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  122

Met His Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Phe Ile Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
        115                 120                 125             


Ser Ile Leu 
    130     


<210>  123
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  123

Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly 
1               5                   10                  15      


Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr 
            20                  25                  30          


Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile 
        35                  40                  45              


Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val 
    50                  55                  60                  


Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Lys Ser Thr Gly 
                85                  90                  95      


Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro 
            100                 105                 110     


<210>  124
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  124

Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met Gly Met Thr 
1               5                   10                  15      


Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His Asn Ala Met 
            20                  25                  30          


Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu Met Phe Val 
        35                  40                  45              


Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His Leu His Thr 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Arg Val 
                85                  90                  95      


Glu Gly Ser Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu 
    


<210>  125
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Ser Thr Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr 
        115                 120                 125             


Val Ile Pro 
    130     


<210>  126
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126

Met His Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Val Glu Gly Ser Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu 
    130         


<210>  127
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  127

Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly 
1               5                   10                  15      


Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
        35                  40                  45              


Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu 
    50                  55                  60                  


Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser 
65                  70                  75                  80  


Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Pro 
                85                  90                  95      


Thr Val Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu 
            100                 105                 110         


Lys Val Leu Ala 
        115     


<210>  128
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  128

Gly Ala Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Ile Arg Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
            100                 105                 110         


Arg Leu Leu Val Leu 
        115         


<210>  129
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Pro Thr Val Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly 
        115                 120                 125             


Thr Arg Leu Lys Val Leu Ala 
    130                 135 


<210>  130
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130

Met His Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ile Arg 
            100                 105                 110         


Asp Arg Ser Gly Gly Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu 
    130     


<210>  131
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  131

Gln Gln Gln Val Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly 
1               5                   10                  15      


Gly Ile Ser Ile Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr 
            20                  25                  30          


Phe Pro Trp Tyr Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile 
        35                  40                  45              


Ala Ile Arg Pro Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Phe Asn Lys Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Thr Tyr Phe Cys Ala Ala Lys Arg Gln Gly 
                85                  90                  95      


Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn 
            100                 105                 110         


Pro 
    


<210>  132
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  132

Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr Glu Lys Gly 
1               5                   10                  15      


Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe Leu Ile Tyr 
        35                  40                  45              


Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu Thr Ile Gln 
65                  70                  75                  80  


Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu 
                85                  90                  95      


Gly Gly Ser Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu 
            100                 105                 110         


Val Leu 
        


<210>  133
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133

Met Ala Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Lys Arg Gln Gly Gly Ser Glu Lys 
        115                 120                 125             


Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro 
    130                 135                 140     


<210>  134
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  134

Met His Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Gly Ser Ser Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu 
    130             


<210>  135
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  135

Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly 
1               5                   10                  15      


Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr 
            20                  25                  30          


Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile 
        35                  40                  45              


Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val 
    50                  55                  60                  


Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Lys Arg Arg Gly 
                85                  90                  95      


Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn 
            100                 105                 110         


Pro 
    


<210>  136
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  136

Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr Glu Lys Gly 
1               5                   10                  15      


Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr 
        35                  40                  45              


Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg 
    50                  55                  60                  


Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu Lys Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Gly Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu 
            100                 105                 110         


Val Leu 
        


<210>  137
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Lys Arg Arg Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Asn Pro 
    130             


<210>  138
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Gly Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu 
    130             


<210>  139
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  139

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  140
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  140

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  141
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Asn, Asp, His, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  X is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  X is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  X is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  141

Xaa Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Xaa 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Xaa 
            100                 105                 110         


Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  142
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  X is Ser or Cys

<400>  142

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  143
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Asn, Asp, His, or Tyr

<400>  143

Xaa Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  144
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Asn, Asp, His, or Tyr

<400>  144

Xaa Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  145
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  146
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  147
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Asn, Asp, His, or Tyr

<400>  147

Xaa Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  148
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  149
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  150
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is alpha-aminobutyric acid (AABA)

<400>  150

Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 
1               5                   10                  15      


Glu Val Gly Ser Asp Xaa Thr Thr Ile 
            20                  25  


<210>  151
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is alpha-aminobutyric acid (AABA)

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is alpha-aminobutyric acid (AABA)

<400>  151

Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Xaa Glu Pro Pro 
1               5                   10                  15      


Glu Val Gly Ser Asp Xaa Thr Thr Ile 
            20                  25  


