                         SEQUENCE LISTING

<110>  Kenjockety Biotechnology
       Arathoon, William Robert
       Briante, Raffaella
       Ponath, Paul David	
       Tan, Cindy
       Theolis, Richard
       Zhai, Qianting
       Zhang, Pingping
 
<120>  ANTI-ABCC1 ANTIBODIES AND USES THEREOF

<130>  KNJY-006WO

<150>  US 63/073,826
<151>  2020-09-02

<160>  184   

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  1

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Asp Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Leu Arg Tyr Gly Tyr Asp Gly Phe Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Val Gln Met Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Asp Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Leu Arg Tyr Gly Tyr Asp Gly Phe Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Glu Val Glu Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg His Thr Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Val 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  4
<211>  125
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Glu Val Gln Leu Thr Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Leu Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Glu Arg Gly Trp Asn Tyr Pro Gly Ile Thr Asn Gly Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  5
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Glu Ile Gln Leu Ala Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Gly Trp Gly Tyr Asp Val Tyr Ser Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Ile Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg His Thr Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  7
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Ile Tyr Tyr Asn Leu Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asn Thr Ser Lys Gly His Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Val 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Phe Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Glu Val Gln Arg Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Ile Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Ile Thr Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120         


<210>  9
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Met Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Gly 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Trp Tyr Asn Trp Gly Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  123
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Glu Val Gln Leu Thr Glu Ser Gly Leu Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Arg Gln Pro Thr Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Tyr Thr Asp Ser Asn Ser Pro Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Glu Asp Ile Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg His Thr Met Gly Ile Thr Lys Ser Trp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120             


<210>  11
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Glu Val Gln Leu Thr Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg His Thr Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Asn Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Trp Ser Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120         


<210>  12
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Glu Val Lys Leu Leu Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Gly Leu Lys 
    50                  55                  60                  


Ser Arg Leu Gly Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Ala Arg Gly Thr Thr Thr Ala Tyr Phe Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Ser Ser 
        115                 120 


<210>  13
<211>  125
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Glu Val Gln Leu Thr Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Leu Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Glu Arg Gly Trp Asn Tyr Pro Gly Ile Thr Asn Gly Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  14
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Asn Gly Gly Asn Ile Tyr His Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asn Thr Ala Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  123
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Asn Val His Trp Val Arg Gln Pro Thr Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Trp Thr Gly Gly Tyr Thr Asp Tyr Asn Ser Asp Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Gly Leu Gln Thr Glu Asp Val Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg His Thr Met Gly Ile Thr Lys Ser Trp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120             


<210>  16
<211>  125
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Glu Val Gln Leu Thr Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Ser Ser Val Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Glu Arg Gly Trp Asn Tyr Pro Phe Ile Thr Asn Gly Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  17
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Met Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg His Thr Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120         


<210>  18
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Gly Leu Lys 
    50                  55                  60                  


Ser Arg Leu Gly Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Ala Arg Gly Thr Thr Thr Ala Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Ile Tyr Tyr Asn Leu Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asn Thr Ser Lys Gly Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr His Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asn Thr Ala Gln Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  21
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  21

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asn Thr Ser Lys Arg Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  22
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Asn Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg His Thr Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  23
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  23

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Val Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Ala Arg Gly Thr Thr Thr Ala Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  24

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Met Ser Ser Gly Gly Ser Ile Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg His Thr Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Thr 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120         


<210>  25
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  25

Asp Ser Trp Ile His 
1               5   


<210>  26
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  26

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Asn Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Trp Thr Gly Gly Tyr Thr Asp Tyr Asn Ser Asp Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg His Thr Met Gly Ile Thr Lys Ser Trp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  27
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  27

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  28
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  28

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Arg Gly Tyr Tyr Trp Ser Asn Trp Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  29
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  29

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Glu Arg Gly Trp Asn Tyr Pro Phe Ile Thr Asn Gly Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  30
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  30

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Gln 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Glu Arg Gly Trp Asn Tyr Pro Phe Ile Thr Ser Gly Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  31
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  31

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Gly Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Ala Arg Gly Thr Thr Thr Ala Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ile Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Gly Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Ala Arg Gly Thr Thr Thr Ala Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  33

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Val Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Ala Arg Gly Thr Thr Thr Ala Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Val Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Thr 
                85                  90                  95      


Arg Ala Arg Gly Thr Thr Thr Ala Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  35
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  35

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Ser 
            20                  25                  30          


Gly Val Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Val Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Ala Arg Gly Thr Thr Thr Ala Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  36
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Ser 
            20                  25                  30          


Gly Val Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Val Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Thr 
                85                  90                  95      


Arg Ala Arg Gly Thr Thr Thr Ala Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  37

Ser Tyr Asp Ile Thr 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  38

Ser Asn Gly Val Ser 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  39

Gly Tyr Phe Met Asn 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  40

Asn Asn Gly Val Ser 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  41

Ser Tyr Asn Val His 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  42

Ser Asn Gly Val Ile 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  43

Asn Tyr Asn Val His 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  44

Ser Asn Gly Val Thr 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  45

Ser Gln Gly Val Ser 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  46

Ser Ser Gly Val Thr 
1               5   


<210>  47
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  47

Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Phe Met Ser 
1               5                   10                  15      


<210>  48
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  48

Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Phe Lys Ser 
1               5                   10                  15      


<210>  49
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  49

Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  50
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  50

Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  51

Ala Ile Ser Ser Gly Gly Ser Ile Tyr Tyr Asn Ser Ala Phe Lys Ser 
1               5                   10                  15      


<210>  52
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  52

Ala Ile Ser Ser Gly Gly Ser Ile Tyr Tyr Asn Leu Ala Phe Lys Ser 
1               5                   10                  15      


<210>  53
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  53

Ala Met Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Phe Lys Ser 
1               5                   10                  15      


<210>  54
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  54

Val Ile Trp Thr Gly Gly Tyr Thr Asp Ser Asn Ser Pro Leu Lys Ser 
1               5                   10                  15      


<210>  55
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  55

Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Phe Lys Ser 
1               5                   10                  15      


<210>  56
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  56

Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Gly Leu Lys Ser 
1               5                   10                  15      


<210>  57
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  57

Ala Ile Ser Asn Gly Gly Asn Ile Tyr His Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  58
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  58

Ile Ile Trp Thr Gly Gly Tyr Thr Asp Tyr Asn Ser Asp Leu Lys Ser 
1               5                   10                  15      


<210>  59
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  59

Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Val Leu Lys Ser 
1               5                   10                  15      


<210>  60
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  60

Ala Ile Ser Ser Gly Gly Asn Ile Tyr His Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  61
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  61

Ala Ile Ser Asn Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Phe Lys Ser 
1               5                   10                  15      


<210>  62
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  62

Ala Ile Ser Ser Gly Gly Asn Ile Tyr Tyr Asn Ser Ala Val Lys Ser 
1               5                   10                  15      


<210>  63
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  63

Ala Met Ser Ser Gly Gly Ser Ile Tyr Tyr Asn Ser Ala Phe Lys Ser 
1               5                   10                  15      


<210>  64
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  64

Asp Leu Arg Tyr Gly Tyr Asp Gly Phe Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  65
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  65

His Arg Gly Tyr Tyr Gly Tyr Asn Trp Gly Tyr Phe Asp Tyr 
1               5                   10                  


<210>  66
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  66

Glu Arg Gly Trp Asn Tyr Pro Gly Ile Thr Asn Gly Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  67
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  67

Ser Gly Trp Gly Tyr Asp Val Tyr Ser Phe Asp Tyr 
1               5                   10          


<210>  68
<211>  14
<212>  PRT
<213>  Rattus norvegicus

<400>  68

His Arg Gly Tyr Tyr Gly Phe Asn Trp Gly Tyr Phe Asp Tyr 
1               5                   10                  


<210>  69
<211>  14
<212>  PRT
<213>  Rattus norvegicus

<400>  69

His Arg Gly Tyr Tyr Trp Tyr Asn Trp Gly Phe Phe Asp Tyr 
1               5                   10                  


<210>  70
<211>  15
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  70

Glu Arg His Thr Met Gly Ile Thr Lys Ser Trp Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  71
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  71

His Arg Gly Tyr Tyr Trp Ser Asn Trp Gly Tyr Phe Asp Tyr 
1               5                   10                  


<210>  72
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  72

Ala Arg Gly Thr Thr Thr Ala Tyr Phe Met Asp Ala 
1               5                   10          


<210>  73
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  73

Glu Arg Gly Trp Asn Tyr Pro Phe Ile Thr Asn Gly Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  74
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  74

Ala Arg Gly Thr Thr Thr Ala Tyr Val Met Asp Ala 
1               5                   10          


<210>  75
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  75

Glu Arg Gly Trp Asn Tyr Pro Phe Ile Thr Ser Gly Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  76
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  Mus musculus or humanized sequence

<400>  76

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Thr Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  77
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  Mus musculus or humanized sequence

<400>  77

Asp Val Val Met Thr Gln Ala Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ile Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Tyr Gly Ser 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  78
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gly Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Trp Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  79
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  79

Asp Ile Val Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Leu Ser Cys Lys Ala Gly Gln Lys Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Trp Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  80
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  80

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  81
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  81

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Ser Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  82
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  82

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  83
<211>  110
<212>  PRT
<213>  Rattus norvegicus

<400>  83

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala 
            100                 105                 110 


<210>  84
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  84

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  85
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  85

Asp Val Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Ile Ser Ile Glu Cys Leu Ala Ser Glu Gly Ile Phe Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Thr Leu Gln Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Ser Met Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Asp Tyr Phe Cys Gln Gln Ser Tyr Lys Phe Pro Val 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  86
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  86

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Leu Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  87
<211>  114
<212>  PRT
<213>  Rattus norvegicus

<400>  87

Glu Thr Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asp Thr Leu Met Lys Met Phe Gly Ala Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys 
        


<210>  88
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  88

Asn Ile Gln Val Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  89
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  89

Asp Ile Leu Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Ile Ser Ile Glu Cys Leu Ala Ser Glu Gly Ile Phe Ser Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Ser Leu Gln Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Ser Met Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Asp Tyr Phe Cys Gln Gln Ser Tyr Lys Phe Pro Val 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  90
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  90

Glu Ile Met Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Ala Gly Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Trp Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  91
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  91

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Asp Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  92
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  92

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Arg Cys Lys Gly Ser Gln Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Asn Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  93
<211>  114
<212>  PRT
<213>  Rattus norvegicus

<400>  93

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Thr Val Asn Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Val Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asp Thr Leu Met Lys Met Phe Gly Ala Gly Thr Lys Leu Glu 
            100                 105                 110         


Leu Lys 
        


<210>  94
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  94

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  95
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  95

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  96
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  96

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  97
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  97

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  98
<211>  114
<212>  PRT
<213>  Rattus norvegicus

<400>  98

Asp Val Val Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asp Val Leu Met Asn Met Phe Gly Ala Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys 
        


<210>  99
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  99

Asn Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Ser Ser Leu Gln Ala Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Asp Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  100
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  100

Asp Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Arg Cys Lys Gly Ser Gln Asn Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Asn Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Val Glu Leu Lys 
            100                 105     


<210>  101
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  101

Asp Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Leu Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  102
<211>  114
<212>  PRT
<213>  Rattus norvegicus

<400>  102

Asp Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Val Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val 
        


<210>  103
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  103

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Gly Ile Phe Ser Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Ser Leu Gln Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Phe Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  104
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  104

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  105
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  105

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  106
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  106

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  107
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  107

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Cys Gln Tyr Asn Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  108
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  108

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gly Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  109
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  109

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Val Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asp Thr Leu Met Lys Met Phe Gly Ala Gly Thr Lys Leu Glu 
            100                 105                 110         


Leu Lys 
        


<210>  110
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  110

Asp Val Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asp Val Leu Met Asn Met Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys 
        


<210>  111
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  111

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  112
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  112

Arg Ala Ser Gln Asp Ile Tyr Gly Ser Leu Asn 
1               5                   10      


<210>  113
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  113

Lys Gly Ser Gln Asn Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  114
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  114

Lys Ala Gly Gln Lys Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  115
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  115

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  116

Lys Gly Ser Gln Asn Ile Asp Asn Tyr Leu Ala 
1               5                   10      


<210>  117
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  117

Leu Ala Ser Glu Gly Ile Phe Ser Tyr Leu Ala 
1               5                   10      


<210>  118
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  118

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  119
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  119

Lys Gly Ser Gln Asn Ile Tyr Asn Tyr Leu Ala 
1               5                   10      


<210>  120
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  120

Leu Ala Ser Glu Gly Ile Phe Ser Tyr Leu Gly 
1               5                   10      


<210>  121
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  121

Lys Ala Gly Gln Asn Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  122
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  122

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Val Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  123
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  123

Lys Gly Ser Gln Asn Ile Asn Asn Tyr Leu Gly 
1               5                   10      


<210>  124
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  124

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  125
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  125

Gly Thr Ser Ser Leu Asp Ser 
1               5           


<210>  126
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  126

Lys Thr Asn Ser Leu Gln Thr 
1               5           


<210>  127
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  127

Asn Ala Asn Ser Leu Gln Thr 
1               5           


<210>  128
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  128

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  129
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  129

Gly Ala Asn Thr Leu Gln Ala 
1               5           


<210>  130
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  130

Trp Ala Ser Thr Arg Gln Ser 
1               5           


<210>  131
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  131

Gly Ala Asn Ser Leu Gln Ala 
1               5           


<210>  132
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  132

Lys Thr Asn Asn Leu Gln Thr 
1               5           


<210>  133
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  133

Lys Thr Ser Ser Leu Gln Ala 
1               5           


<210>  134
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  134

Glu Thr Asn Ser Leu Gln Thr 
1               5           


<210>  135
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  135

Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  136

Leu Gln Tyr Ala Ser Tyr Pro Tyr Thr 
1               5                   


<210>  137
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  137

Tyr Gln Tyr Asn Asn Trp Tyr Thr 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  138

Gln Gln Tyr Asn Ser Trp Tyr Thr 
1               5               


<210>  139
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  139

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  140
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  140

Ser Gln Tyr Asn Asn Gly Tyr Thr 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  141

Tyr Gln Tyr Asn Asp Gly Tyr Thr 
1               5               


<210>  142
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  142

Tyr Gln Tyr Asn Asn Gly Tyr Thr 
1               5               


<210>  143
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  143

Cys Gln Tyr Asn Asn Gly Tyr Thr 
1               5               


<210>  144
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  144

Gln Gln Ser Tyr Lys Phe Pro Val Thr 
1               5                   


<210>  145
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  145

Cys Gln Tyr Asn Asp Gly Tyr Thr 
1               5               


<210>  146
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  146

Gln Gln Tyr Tyr Asp Thr Leu Met Lys Met 
1               5                   10  


<210>  147
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or humanized sequence

<400>  147

Gln Gln Tyr Tyr Asp Val Leu Met Asn Met 
1               5                   10  


<210>  148
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  148

Tyr Gln Tyr Asn Gln Gly Tyr Thr 
1               5               


<210>  149
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  149

Tyr Gln Tyr Asn Ser Gly Tyr Thr 
1               5               


<210>  150
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
        35                  40                  45              


Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
    50                  55                  60                  


Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
65                  70                  75                  80  


Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                85                  90                  95      


Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
            100                 105                 110         


Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
        115                 120                 125             


Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
    130                 135                 140                 


Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
145                 150                 155                 160 


Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 
                165                 170                 175     


Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
            180                 185                 190         


Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
        195                 200                 205             


Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
    210                 215                 220                 


Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
225                 230                 235                 240 


Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                245                 250                 255     


Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
            260                 265                 270         


Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 
        275                 280                 285             


Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
    290                 295                 300                 


Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
305                 310                 315                 320 


Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                325                 330                 335     


Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 
            340                 345                 350         


Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 
        355                 360                 365             


Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
    370                 375                 380                 


Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
385                 390                 395                 400 


Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 
                405                 410                 415     


Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
            420                 425                 430         


Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
        435                 440                 445             


Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 
    450                 455                 460                 


Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
465                 470                 475                 480 


Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                485                 490                 495     


Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
            500                 505                 510         


Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
        515                 520                 525             


Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
    530                 535                 540                 


Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
545                 550                 555                 560 


Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 
                565                 570                 575     


Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
            580                 585                 590         


Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
        595                 600                 605             


Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
    610                 615                 620                 


Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 
625                 630                 635                 640 


Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                645                 650                 655     


Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
            660                 665                 670         


Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
        675                 680                 685             


Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 
    690                 695                 700                 


Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
705                 710                 715                 720 


Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                725                 730                 735     


Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
            740                 745                 750         


Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
        755                 760                 765             


Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 
    770                 775                 780                 


Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
785                 790                 795                 800 


His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                805                 810                 815     


Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
            820                 825                 830         


Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
        835                 840                 845             


Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
    850                 855                 860                 


Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 
865                 870                 875                 880 


Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                885                 890                 895     


Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
            900                 905                 910         


Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 
        915                 920                 925             


Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 
    930                 935                 940                 


Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
945                 950                 955                 960 


Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                965                 970                 975     


Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 
            980                 985                 990         


Asn Tyr Trp Leu Ser Leu Trp Thr  Asp Asp Pro Ile Val  Asn Gly Thr 
        995                 1000                 1005             


Gln Glu  His Thr Lys Val Arg  Leu Ser Val Tyr Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ile Ser  Gln Gly Ile Ala Val  Phe Gly Tyr Ser Met  Ala Val Ser 
    1025                 1030                 1035             


Ile Gly  Gly Ile Leu Ala Ser  Arg Cys Leu His Val  Asp Leu Leu 
    1040                 1045                 1050             


His Ser  Ile Leu Arg Ser Pro  Met Ser Phe Phe Glu  Arg Thr Pro 
    1055                 1060                 1065             


Ser Gly  Asn Leu Val Asn Arg  Phe Ser Lys Glu Leu  Asp Thr Val 
    1070                 1075                 1080             


Asp Ser  Met Ile Pro Glu Val  Ile Lys Met Phe Met  Gly Ser Leu 
    1085                 1090                 1095             


Phe Asn  Val Ile Gly Ala Cys  Ile Val Ile Leu Leu  Ala Thr Pro 
    1100                 1105                 1110             


Ile Ala  Ala Ile Ile Ile Pro  Pro Leu Gly Leu Ile  Tyr Phe Phe 
    1115                 1120                 1125             


Val Gln  Arg Phe Tyr Val Ala  Ser Ser Arg Gln Leu  Lys Arg Leu 
    1130                 1135                 1140             


Glu Ser  Val Ser Arg Ser Pro  Val Tyr Ser His Phe  Asn Glu Thr 
    1145                 1150                 1155             


Leu Leu  Gly Val Ser Val Ile  Arg Ala Phe Glu Glu  Gln Glu Arg 
    1160                 1165                 1170             


Phe Ile  His Gln Ser Asp Leu  Lys Val Asp Glu Asn  Gln Lys Ala 
    1175                 1180                 1185             


Tyr Tyr  Pro Ser Ile Val Ala  Asn Arg Trp Leu Ala  Val Arg Leu 
    1190                 1195                 1200             


Glu Cys  Val Gly Asn Cys Ile  Val Leu Phe Ala Ala  Leu Phe Ala 
    1205                 1210                 1215             


Val Ile  Ser Arg His Ser Leu  Ser Ala Gly Leu Val  Gly Leu Ser 
    1220                 1225                 1230             


Val Ser  Tyr Ser Leu Gln Val  Thr Thr Tyr Leu Asn  Trp Leu Val 
    1235                 1240                 1245             


Arg Met  Ser Ser Glu Met Glu  Thr Asn Ile Val Ala  Val Glu Arg 
    1250                 1255                 1260             


Leu Lys  Glu Tyr Ser Glu Thr  Glu Lys Glu Ala Pro  Trp Gln Ile 
    1265                 1270                 1275             


Gln Glu  Thr Ala Pro Pro Ser  Ser Trp Pro Gln Val  Gly Arg Val 
    1280                 1285                 1290             


Glu Phe  Arg Asn Tyr Cys Leu  Arg Tyr Arg Glu Asp  Leu Asp Phe 
    1295                 1300                 1305             


Val Leu  Arg His Ile Asn Val  Thr Ile Asn Gly Gly  Glu Lys Val 
    1310                 1315                 1320             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Ser  Leu Thr Leu 
    1325                 1330                 1335             


Gly Leu  Phe Arg Ile Asn Glu  Ser Ala Glu Gly Glu  Ile Ile Ile 
    1340                 1345                 1350             


Asp Gly  Ile Asn Ile Ala Lys  Ile Gly Leu His Asp  Leu Arg Phe 
    1355                 1360                 1365             


Lys Ile  Thr Ile Ile Pro Gln  Asp Pro Val Leu Phe  Ser Gly Ser 
    1370                 1375                 1380             


Leu Arg  Met Asn Leu Asp Pro  Phe Ser Gln Tyr Ser  Asp Glu Glu 
    1385                 1390                 1395             


Val Trp  Thr Ser Leu Glu Leu  Ala His Leu Lys Asp  Phe Val Ser 
    1400                 1405                 1410             


Ala Leu  Pro Asp Lys Leu Asp  His Glu Cys Ala Glu  Gly Gly Glu 
    1415                 1420                 1425             


Asn Leu  Ser Val Gly Gln Arg  Gln Leu Val Cys Leu  Ala Arg Ala 
    1430                 1435                 1440             


Leu Leu  Arg Lys Thr Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala 
    1445                 1450                 1455             


Ala Val  Asp Leu Glu Thr Asp  Asp Leu Ile Gln Ser  Thr Ile Arg 
    1460                 1465                 1470             


Thr Gln  Phe Glu Asp Cys Thr  Val Leu Thr Ile Ala  His Arg Leu 
    1475                 1480                 1485             


Asn Thr  Ile Met Asp Tyr Thr  Arg Val Ile Val Leu  Asp Lys Gly 
    1490                 1495                 1500             


Glu Ile  Gln Glu Tyr Gly Ala  Pro Ser Asp Leu Leu  Gln Gln Arg 
    1505                 1510                 1515             


Gly Leu  Phe Tyr Ser Met Ala  Lys Asp Ala Gly Leu  Val 
    1520                 1525                 1530     


<210>  151
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe 
    


<210>  152
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  152

Arg Ser Arg Gly Ile 
1               5   


<210>  153
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  153

Ser Lys Ile Met Thr Ala Leu Lys Glu Asp Ala Gln Val Asp Leu Phe 
1               5                   10                  15      


Arg Asp 
        


<210>  154
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe Val 
1               5                   10                  15      


Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly 
            20                  25      


<210>  155
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  155

Val Thr Ile Asp Glu Asn Asn Ile Leu Asp Ala Gln Thr Ala Phe Val 
1               5                   10                  15      


Ser Leu Ala Leu Phe Asn 
            20          


<210>  156
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  156

Ala Leu Ala Ser Asn Tyr Trp Leu Ser Leu Trp Thr Asp Asp Pro Ile 
1               5                   10                  15      


Val Asn Gly Thr Gln Glu His Thr Lys Val Arg Leu Ser Val Tyr Gly 
            20                  25                  30          


Ala Leu Gly Ile Ser 
        35          


<210>  157
<211>  1329
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Asp Pro Asn Pro Cys Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg 
1               5                   10                  15      


Ile Thr Phe Trp Trp Ile Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln 
            20                  25                  30          


Pro Leu Glu Gly Ser Asp Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser 
        35                  40                  45              


Glu Gln Val Val Pro Val Leu Val Lys Asn Trp Lys Lys Glu Cys Ala 
    50                  55                  60                  


Lys Thr Arg Lys Gln Pro Val Lys Val Val Tyr Ser Ser Lys Asp Pro 
65                  70                  75                  80  


Ala Gln Pro Lys Glu Ser Ser Lys Val Asp Ala Asn Glu Glu Val Glu 
                85                  90                  95      


Ala Leu Ile Val Lys Ser Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe 
            100                 105                 110         


Lys Val Leu Tyr Lys Thr Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe 
        115                 120                 125             


Phe Lys Ala Ile His Asp Leu Met Met Phe Ser Gly Pro Gln Ile Leu 
    130                 135                 140                 


Lys Leu Leu Ile Lys Phe Val Asn Asp Thr Lys Ala Pro Asp Trp Gln 
145                 150                 155                 160 


Gly Tyr Phe Tyr Thr Val Leu Leu Phe Val Thr Ala Cys Leu Gln Thr 
                165                 170                 175     


Leu Val Leu His Gln Tyr Phe His Ile Cys Phe Val Ser Gly Met Arg 
            180                 185                 190         


Ile Lys Thr Ala Val Ile Gly Ala Val Tyr Arg Lys Ala Leu Val Ile 
        195                 200                 205             


Thr Asn Ser Ala Arg Lys Ser Ser Thr Val Gly Glu Ile Val Asn Leu 
    210                 215                 220                 


Met Ser Val Asp Ala Gln Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn 
225                 230                 235                 240 


Met Ile Trp Ser Ala Pro Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu 
                245                 250                 255     


Trp Leu Asn Leu Gly Pro Ser Val Leu Ala Gly Val Ala Val Met Val 
            260                 265                 270         


Leu Met Val Pro Val Asn Ala Val Met Ala Met Lys Thr Lys Thr Tyr 
        275                 280                 285             


Gln Val Ala His Met Lys Ser Lys Asp Asn Arg Ile Lys Leu Met Asn 
    290                 295                 300                 


Glu Ile Leu Asn Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu 
305                 310                 315                 320 


Ala Phe Lys Asp Lys Val Leu Ala Ile Arg Gln Glu Glu Leu Lys Val 
                325                 330                 335     


Leu Lys Lys Ser Ala Tyr Leu Ser Ala Val Gly Thr Phe Thr Trp Val 
            340                 345                 350         


Cys Thr Pro Phe Leu Val Ala Leu Cys Thr Phe Ala Val Tyr Val Thr 
        355                 360                 365             


Ile Asp Glu Asn Asn Ile Leu Asp Ala Gln Thr Ala Phe Val Ser Leu 
    370                 375                 380                 


Ala Leu Phe Asn Ile Leu Arg Phe Pro Leu Asn Ile Leu Pro Met Val 
385                 390                 395                 400 


Ile Ser Ser Ile Val Gln Ala Ser Val Ser Leu Lys Arg Leu Arg Ile 
                405                 410                 415     


Phe Leu Ser His Glu Glu Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro 
            420                 425                 430         


Val Lys Asp Gly Gly Gly Thr Asn Ser Ile Thr Val Arg Asn Ala Thr 
        435                 440                 445             


Phe Thr Trp Ala Arg Ser Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe 
    450                 455                 460                 


Ser Ile Pro Glu Gly Ala Leu Val Ala Val Val Gly Gln Val Gly Cys 
465                 470                 475                 480 


Gly Lys Ser Ser Leu Leu Ser Ala Leu Leu Ala Glu Met Asp Lys Val 
                485                 490                 495     


Glu Gly His Val Ala Ile Lys Gly Ser Val Ala Tyr Val Pro Gln Gln 
            500                 505                 510         


Ala Trp Ile Gln Asn Asp Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys 
        515                 520                 525             


Gln Leu Glu Glu Pro Tyr Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu 
    530                 535                 540                 


Leu Pro Asp Leu Glu Ile Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly 
545                 550                 555                 560 


Glu Lys Gly Val Asn Leu Ser Gly Gly Gln Lys Gln Arg Val Ser Leu 
                565                 570                 575     


Ala Arg Ala Val Tyr Ser Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro 
            580                 585                 590         


Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile Phe Glu Asn Val 
        595                 600                 605             


Ile Gly Pro Lys Gly Met Leu Lys Asn Lys Thr Arg Ile Leu Val Thr 
    610                 615                 620                 


His Ser Met Ser Tyr Leu Pro Gln Val Asp Val Ile Ile Val Met Ser 
625                 630                 635                 640 


Gly Gly Lys Ile Ser Glu Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg 
                645                 650                 655     


Asp Gly Ala Phe Ala Glu Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln 
            660                 665                 670         


Glu Gln Asp Ala Glu Glu Asn Gly Val Thr Gly Val Ser Gly Pro Gly 
        675                 680                 685             


Lys Glu Ala Lys Gln Met Glu Asn Gly Met Leu Val Thr Asp Ser Ala 
    690                 695                 700                 


Gly Lys Gln Leu Gln Arg Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly 
705                 710                 715                 720 


Asp Ile Ser Arg His His Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu 
                725                 730                 735     


Ala Lys Lys Glu Glu Thr Trp Lys Leu Met Glu Ala Asp Lys Ala Gln 
            740                 745                 750         


Thr Gly Gln Val Lys Leu Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile 
        755                 760                 765             


Gly Leu Phe Ile Ser Phe Leu Ser Ile Phe Leu Phe Met Cys Asn His 
    770                 775                 780                 


Val Ser Ala Leu Ala Ser Asn Tyr Trp Leu Ser Leu Trp Thr Asp Asp 
785                 790                 795                 800 


Pro Ile Val Asn Gly Thr Gln Glu His Thr Lys Val Arg Leu Ser Val 
                805                 810                 815     


Tyr Gly Ala Leu Gly Ile Ser Gln Gly Ile Ala Val Phe Gly Tyr Ser 
            820                 825                 830         


Met Ala Val Ser Ile Gly Gly Ile Leu Ala Ser Arg Cys Leu His Val 
        835                 840                 845             


Asp Leu Leu His Ser Ile Leu Arg Ser Pro Met Ser Phe Phe Glu Arg 
    850                 855                 860                 


Thr Pro Ser Gly Asn Leu Val Asn Arg Phe Ser Lys Glu Leu Asp Thr 
865                 870                 875                 880 


Val Asp Ser Met Ile Pro Glu Val Ile Lys Met Phe Met Gly Ser Leu 
                885                 890                 895     


Phe Asn Val Ile Gly Ala Cys Ile Val Ile Leu Leu Ala Thr Pro Ile 
            900                 905                 910         


Ala Ala Ile Ile Ile Pro Pro Leu Gly Leu Ile Tyr Phe Phe Val Gln 
        915                 920                 925             


Arg Phe Tyr Val Ala Ser Ser Arg Gln Leu Lys Arg Leu Glu Ser Val 
    930                 935                 940                 


Ser Arg Ser Pro Val Tyr Ser His Phe Asn Glu Thr Leu Leu Gly Val 
945                 950                 955                 960 


Ser Val Ile Arg Ala Phe Glu Glu Gln Glu Arg Phe Ile His Gln Ser 
                965                 970                 975     


Asp Leu Lys Val Asp Glu Asn Gln Lys Ala Tyr Tyr Pro Ser Ile Val 
            980                 985                 990         


Ala Asn Arg Trp Leu Ala Val Arg  Leu Glu Cys Val Gly  Asn Cys Ile 
        995                 1000                 1005             


Val Leu  Phe Ala Ala Leu Phe  Ala Val Ile Ser Arg  His Ser Leu 
    1010                 1015                 1020             


Ser Ala  Gly Leu Val Gly Leu  Ser Val Ser Tyr Ser  Leu Gln Val 
    1025                 1030                 1035             


Thr Thr  Tyr Leu Asn Trp Leu  Val Arg Met Ser Ser  Glu Met Glu 
    1040                 1045                 1050             


Thr Asn  Ile Val Ala Val Glu  Arg Leu Lys Glu Tyr  Ser Glu Thr 
    1055                 1060                 1065             


Glu Lys  Glu Ala Pro Trp Gln  Ile Gln Glu Thr Ala  Pro Pro Ser 
    1070                 1075                 1080             


Ser Trp  Pro Gln Val Gly Arg  Val Glu Phe Arg Asn  Tyr Cys Leu 
    1085                 1090                 1095             


Arg Tyr  Arg Glu Asp Leu Asp  Phe Val Leu Arg His  Ile Asn Val 
    1100                 1105                 1110             


Thr Ile  Asn Gly Gly Glu Lys  Val Gly Ile Val Gly  Arg Thr Gly 
    1115                 1120                 1125             


Ala Gly  Lys Ser Ser Leu Thr  Leu Gly Leu Phe Arg  Ile Asn Glu 
    1130                 1135                 1140             


Ser Ala  Glu Gly Glu Ile Ile  Ile Asp Gly Ile Asn  Ile Ala Lys 
    1145                 1150                 1155             


Ile Gly  Leu His Asp Leu Arg  Phe Lys Ile Thr Ile  Ile Pro Gln 
    1160                 1165                 1170             


Asp Pro  Val Leu Phe Ser Gly  Ser Leu Arg Met Asn  Leu Asp Pro 
    1175                 1180                 1185             


Phe Ser  Gln Tyr Ser Asp Glu  Glu Val Trp Thr Ser  Leu Glu Leu 
    1190                 1195                 1200             


Ala His  Leu Lys Asp Phe Val  Ser Ala Leu Pro Asp  Lys Leu Asp 
    1205                 1210                 1215             


His Glu  Cys Ala Glu Gly Gly  Glu Asn Leu Ser Val  Gly Gln Arg 
    1220                 1225                 1230             


Gln Leu  Val Cys Leu Ala Arg  Ala Leu Leu Arg Lys  Thr Lys Ile 
    1235                 1240                 1245             


Leu Val  Leu Asp Glu Ala Thr  Ala Ala Val Asp Leu  Glu Thr Asp 
    1250                 1255                 1260             


Asp Leu  Ile Gln Ser Thr Ile  Arg Thr Gln Phe Glu  Asp Cys Thr 
    1265                 1270                 1275             


Val Leu  Thr Ile Ala His Arg  Leu Asn Thr Ile Met  Asp Tyr Thr 
    1280                 1285                 1290             


Arg Val  Ile Val Leu Asp Lys  Gly Glu Ile Gln Glu  Tyr Gly Ala 
    1295                 1300                 1305             


Pro Ser  Asp Leu Leu Gln Gln  Arg Gly Leu Phe Tyr  Ser Met Ala 
    1310                 1315                 1320             


Lys Asp  Ala Gly Leu Val 
    1325                 


<210>  158
<211>  1531
<212>  PRT
<213>  Macaca fascicularis

<400>  158

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Tyr Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
        35                  40                  45              


Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
    50                  55                  60                  


Ile Gln Met Thr Leu Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
65                  70                  75                  80  


Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                85                  90                  95      


Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
            100                 105                 110         


Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
        115                 120                 125             


Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
    130                 135                 140                 


Ala Leu Leu Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
145                 150                 155                 160 


Leu Lys Glu Asp Val Gln Val Asp Leu Phe Arg Asp Met Thr Phe Tyr 
                165                 170                 175     


Val Tyr Phe Ser Leu Val Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
            180                 185                 190         


Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
        195                 200                 205             


Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
    210                 215                 220                 


Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
225                 230                 235                 240 


Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                245                 250                 255     


Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
            260                 265                 270         


Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Asp Ser 
        275                 280                 285             


Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
    290                 295                 300                 


Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
305                 310                 315                 320 


Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                325                 330                 335     


Leu Met Met Phe Ser Gly Pro Glu Ile Leu Lys Leu Leu Ile Asn Phe 
            340                 345                 350         


Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Ala 
        355                 360                 365             


Leu Leu Phe Val Ala Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
    370                 375                 380                 


Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
385                 390                 395                 400 


Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ala Ala Arg Lys 
                405                 410                 415     


Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
            420                 425                 430         


Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
        435                 440                 445             


Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Arg Asn Leu Gly Pro 
    450                 455                 460                 


Pro Ile Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
465                 470                 475                 480 


Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                485                 490                 495     


Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
            500                 505                 510         


Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
        515                 520                 525             


Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
    530                 535                 540                 


Leu Ala Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
545                 550                 555                 560 


Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Lys Asn Asn Val 
                565                 570                 575     


Leu Asp Ala Gln Lys Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
            580                 585                 590         


Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
        595                 600                 605             


Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
    610                 615                 620                 


Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Asp 
625                 630                 635                 640 


Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                645                 650                 655     


Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
            660                 665                 670         


Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
        675                 680                 685             


Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Leu 
    690                 695                 700                 


Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
705                 710                 715                 720 


Ser Leu Gln Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                725                 730                 735     


Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
            740                 745                 750         


Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
        755                 760                 765             


Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Cys 
    770                 775                 780                 


Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
785                 790                 795                 800 


His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                805                 810                 815     


Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
            820                 825                 830         


Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
        835                 840                 845             


Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
    850                 855                 860                 


Phe Leu Arg Thr Tyr Ala Ser Ala Glu Gln Glu Gln Asp Pro Glu Asp 
865                 870                 875                 880 


Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                885                 890                 895     


Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
            900                 905                 910         


Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Val Ser Arg Gln His 
        915                 920                 925             


Asn Ser Thr Ala Glu Leu Gln Lys Asp Gly Ala Lys Lys Glu Glu Thr 
    930                 935                 940                 


Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
945                 950                 955                 960 


Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                965                 970                 975     


Leu Ser Ile Phe Leu Phe Ile Cys Asn His Val Ala Ala Leu Ala Ser 
            980                 985                 990         


Asn Tyr Trp Leu Ser Leu Trp Thr  Asp Asp Pro Ile Val  Asn Gly Thr 
        995                 1000                 1005             


Gln Glu  His Thr Lys Val Arg  Leu Ser Val Tyr Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ile Ser  Gln Gly Ile Ala Val  Phe Gly Tyr Ser Met  Ala Val Ser 
    1025                 1030                 1035             


Ile Gly  Gly Ile Leu Ala Ser  Arg Cys Leu His Val  Asp Leu Leu 
    1040                 1045                 1050             


His Ser  Ile Leu Arg Ser Pro  Met Ser Phe Phe Glu  Arg Thr Pro 
    1055                 1060                 1065             


Ser Gly  Asn Leu Val Asn Arg  Phe Ser Lys Glu Leu  Asp Thr Val 
    1070                 1075                 1080             


Asp Ser  Met Ile Pro Glu Val  Ile Lys Met Phe Met  Gly Ser Leu 
    1085                 1090                 1095             


Phe Asn  Val Ile Gly Ala Cys  Ile Val Ile Leu Leu  Ala Thr Pro 
    1100                 1105                 1110             


Ile Ala  Ala Ile Ile Ile Pro  Pro Leu Gly Leu Ile  Tyr Phe Phe 
    1115                 1120                 1125             


Val Gln  Arg Phe Tyr Val Ala  Ser Ser Arg Gln Leu  Lys Arg Leu 
    1130                 1135                 1140             


Glu Ser  Val Ser Arg Ser Pro  Val Tyr Ser His Phe  Asn Glu Thr 
    1145                 1150                 1155             


Leu Leu  Gly Val Ser Val Ile  Arg Ala Phe Glu Glu  Gln Glu Arg 
    1160                 1165                 1170             


Phe Ile  His Gln Ser Asp Leu  Lys Val Asp Glu Asn  Gln Lys Ala 
    1175                 1180                 1185             


Tyr Tyr  Pro Ser Ile Val Ala  Asn Arg Trp Leu Ala  Val Arg Leu 
    1190                 1195                 1200             


Glu Cys  Val Gly Asn Cys Ile  Val Leu Phe Ala Ala  Leu Phe Ala 
    1205                 1210                 1215             


Val Ile  Ser Arg His Ser Leu  Ser Ala Gly Leu Val  Gly Leu Ser 
    1220                 1225                 1230             


Val Ser  Tyr Ser Leu Gln Val  Thr Thr Tyr Leu Asn  Trp Leu Val 
    1235                 1240                 1245             


Arg Met  Ser Ser Glu Met Glu  Thr Asn Ile Val Ala  Val Glu Arg 
    1250                 1255                 1260             


Leu Lys  Glu Tyr Ser Glu Thr  Glu Lys Glu Ala Pro  Trp Gln Ile 
    1265                 1270                 1275             


Gln Glu  Thr Ala Pro Pro Ser  Asn Trp Pro Gln Val  Gly Arg Val 
    1280                 1285                 1290             


Glu Phe  Arg Asn Tyr Cys Leu  Arg Tyr Arg Glu Asp  Leu Asp Phe 
    1295                 1300                 1305             


Val Leu  Arg His Ile Asn Val  Thr Ile Asn Gly Gly  Glu Lys Val 
    1310                 1315                 1320             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Ser  Leu Thr Leu 
    1325                 1330                 1335             


Gly Leu  Phe Arg Ile Asn Glu  Ser Ala Glu Gly Glu  Ile Ile Ile 
    1340                 1345                 1350             


Asp Gly  Ile Asn Ile Ala Arg  Ile Gly Leu His Asp  Leu Arg Phe 
    1355                 1360                 1365             


Lys Ile  Thr Ile Ile Pro Gln  Asp Pro Val Leu Phe  Ser Gly Ser 
    1370                 1375                 1380             


Leu Arg  Met Asn Leu Asp Pro  Phe Ser Gln Tyr Ser  Asp Glu Glu 
    1385                 1390                 1395             


Val Trp  Thr Ser Leu Glu Leu  Ala His Leu Lys Gly  Phe Val Ser 
    1400                 1405                 1410             


Ala Leu  Pro Asp Lys Leu Asp  His Glu Cys Ala Glu  Gly Gly Glu 
    1415                 1420                 1425             


Asn Leu  Ser Val Gly Gln Arg  Gln Leu Val Cys Leu  Ala Arg Ala 
    1430                 1435                 1440             


Leu Leu  Arg Lys Thr Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala 
    1445                 1450                 1455             


Ala Val  Asp Leu Glu Thr Asp  Asp Leu Ile Gln Ser  Thr Ile Arg 
    1460                 1465                 1470             


Thr Gln  Phe Glu Asp Cys Thr  Val Leu Thr Ile Ala  His Arg Leu 
    1475                 1480                 1485             


Asn Thr  Ile Met Asp Tyr Thr  Arg Val Ile Val Leu  Asp Lys Gly 
    1490                 1495                 1500             


Glu Ile  Gln Glu Tyr Gly Ala  Pro Ser Asp Leu Leu  Gln Gln Arg 
    1505                 1510                 1515             


Gly Leu  Phe Tyr Asn Met Ala  Arg Asp Ala Gly Leu  Val 
    1520                 1525                 1530     


<210>  159
<211>  1329
<212>  PRT
<213>  Macaca fascicularis

<400>  159

Met Asp Pro Asn Pro Cys Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg 
1               5                   10                  15      


Ile Thr Phe Trp Trp Ile Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln 
            20                  25                  30          


Pro Leu Glu Gly Ser Asp Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser 
        35                  40                  45              


Glu Gln Val Val Pro Val Leu Val Lys Asn Trp Lys Lys Glu Cys Ala 
    50                  55                  60                  


Lys Thr Arg Lys Gln Pro Val Lys Val Val Tyr Ser Ser Lys Asp Pro 
65                  70                  75                  80  


Ala Gln Pro Lys Asp Ser Ser Lys Val Asp Ala Asn Glu Glu Val Glu 
                85                  90                  95      


Ala Leu Ile Val Lys Ser Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe 
            100                 105                 110         


Lys Val Leu Tyr Lys Thr Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe 
        115                 120                 125             


Phe Lys Ala Ile His Asp Leu Met Met Phe Ser Gly Pro Glu Ile Leu 
    130                 135                 140                 


Lys Leu Leu Ile Asn Phe Val Asn Asp Thr Lys Ala Pro Asp Trp Gln 
145                 150                 155                 160 


Gly Tyr Phe Tyr Thr Ala Leu Leu Phe Val Ala Ala Cys Leu Gln Thr 
                165                 170                 175     


Leu Val Leu His Gln Tyr Phe His Ile Cys Phe Val Ser Gly Met Arg 
            180                 185                 190         


Ile Lys Thr Ala Val Ile Gly Ala Val Tyr Arg Lys Ala Leu Val Ile 
        195                 200                 205             


Thr Asn Ala Ala Arg Lys Ser Ser Thr Val Gly Glu Ile Val Asn Leu 
    210                 215                 220                 


Met Ser Val Asp Ala Gln Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn 
225                 230                 235                 240 


Met Ile Trp Ser Ala Pro Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu 
                245                 250                 255     


Trp Arg Asn Leu Gly Pro Pro Ile Leu Ala Gly Val Ala Val Met Val 
            260                 265                 270         


Leu Met Val Pro Val Asn Ala Val Met Ala Met Lys Thr Lys Thr Tyr 
        275                 280                 285             


Gln Val Ala His Met Lys Ser Lys Asp Asn Arg Ile Lys Leu Met Asn 
    290                 295                 300                 


Glu Ile Leu Asn Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu 
305                 310                 315                 320 


Ala Phe Lys Asp Lys Val Leu Ala Ile Arg Gln Glu Glu Leu Lys Val 
                325                 330                 335     


Leu Lys Lys Ser Ala Tyr Leu Ala Ala Val Gly Thr Phe Thr Trp Val 
            340                 345                 350         


Cys Thr Pro Phe Leu Val Ala Leu Cys Thr Phe Ala Val Tyr Val Thr 
        355                 360                 365             


Ile Asp Lys Asn Asn Val Leu Asp Ala Gln Lys Ala Phe Val Ser Leu 
    370                 375                 380                 


Ala Leu Phe Asn Ile Leu Arg Phe Pro Leu Asn Ile Leu Pro Met Val 
385                 390                 395                 400 


Ile Ser Ser Ile Val Gln Ala Ser Val Ser Leu Lys Arg Leu Arg Ile 
                405                 410                 415     


Phe Leu Ser His Glu Glu Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro 
            420                 425                 430         


Val Lys Asp Gly Gly Asp Thr Asn Ser Ile Thr Val Arg Asn Ala Thr 
        435                 440                 445             


Phe Thr Trp Ala Arg Ser Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe 
    450                 455                 460                 


Ser Ile Pro Glu Gly Ala Leu Val Ala Val Val Gly Gln Val Gly Cys 
465                 470                 475                 480 


Gly Lys Ser Ser Leu Leu Ser Ala Leu Leu Ala Glu Met Asp Lys Val 
                485                 490                 495     


Glu Gly His Val Ala Leu Lys Gly Ser Val Ala Tyr Val Pro Gln Gln 
            500                 505                 510         


Ala Trp Ile Gln Asn Asp Ser Leu Gln Glu Asn Ile Leu Phe Gly Cys 
        515                 520                 525             


Gln Leu Glu Glu Pro Tyr Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu 
    530                 535                 540                 


Leu Pro Asp Leu Glu Ile Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly 
545                 550                 555                 560 


Glu Lys Gly Val Asn Leu Ser Gly Gly Gln Lys Gln Arg Val Ser Leu 
                565                 570                 575     


Ala Arg Ala Val Tyr Cys Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro 
            580                 585                 590         


Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile Phe Glu Asn Val 
        595                 600                 605             


Ile Gly Pro Lys Gly Met Leu Lys Asn Lys Thr Arg Ile Leu Val Thr 
    610                 615                 620                 


His Ser Met Ser Tyr Leu Pro Gln Val Asp Val Ile Ile Val Met Ser 
625                 630                 635                 640 


Gly Gly Lys Ile Ser Glu Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg 
                645                 650                 655     


Asp Gly Ala Phe Ala Glu Phe Leu Arg Thr Tyr Ala Ser Ala Glu Gln 
            660                 665                 670         


Glu Gln Asp Pro Glu Asp Asn Gly Val Thr Gly Val Ser Gly Pro Gly 
        675                 680                 685             


Lys Glu Ala Lys Gln Met Glu Asn Gly Met Leu Val Thr Asp Ser Ala 
    690                 695                 700                 


Gly Lys Gln Leu Gln Arg Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly 
705                 710                 715                 720 


Asp Val Ser Arg Gln His Asn Ser Thr Ala Glu Leu Gln Lys Asp Gly 
                725                 730                 735     


Ala Lys Lys Glu Glu Thr Trp Lys Leu Met Glu Ala Asp Lys Ala Gln 
            740                 745                 750         


Thr Gly Gln Val Lys Leu Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile 
        755                 760                 765             


Gly Leu Phe Ile Ser Phe Leu Ser Ile Phe Leu Phe Ile Cys Asn His 
    770                 775                 780                 


Val Ala Ala Leu Ala Ser Asn Tyr Trp Leu Ser Leu Trp Thr Asp Asp 
785                 790                 795                 800 


Pro Ile Val Asn Gly Thr Gln Glu His Thr Lys Val Arg Leu Ser Val 
                805                 810                 815     


Tyr Gly Ala Leu Gly Ile Ser Gln Gly Ile Ala Val Phe Gly Tyr Ser 
            820                 825                 830         


Met Ala Val Ser Ile Gly Gly Ile Leu Ala Ser Arg Cys Leu His Val 
        835                 840                 845             


Asp Leu Leu His Ser Ile Leu Arg Ser Pro Met Ser Phe Phe Glu Arg 
    850                 855                 860                 


Thr Pro Ser Gly Asn Leu Val Asn Arg Phe Ser Lys Glu Leu Asp Thr 
865                 870                 875                 880 


Val Asp Ser Met Ile Pro Glu Val Ile Lys Met Phe Met Gly Ser Leu 
                885                 890                 895     


Phe Asn Val Ile Gly Ala Cys Ile Val Ile Leu Leu Ala Thr Pro Ile 
            900                 905                 910         


Ala Ala Ile Ile Ile Pro Pro Leu Gly Leu Ile Tyr Phe Phe Val Gln 
        915                 920                 925             


Arg Phe Tyr Val Ala Ser Ser Arg Gln Leu Lys Arg Leu Glu Ser Val 
    930                 935                 940                 


Ser Arg Ser Pro Val Tyr Ser His Phe Asn Glu Thr Leu Leu Gly Val 
945                 950                 955                 960 


Ser Val Ile Arg Ala Phe Glu Glu Gln Glu Arg Phe Ile His Gln Ser 
                965                 970                 975     


Asp Leu Lys Val Asp Glu Asn Gln Lys Ala Tyr Tyr Pro Ser Ile Val 
            980                 985                 990         


Ala Asn Arg Trp Leu Ala Val Arg  Leu Glu Cys Val Gly  Asn Cys Ile 
        995                 1000                 1005             


Val Leu  Phe Ala Ala Leu Phe  Ala Val Ile Ser Arg  His Ser Leu 
    1010                 1015                 1020             


Ser Ala  Gly Leu Val Gly Leu  Ser Val Ser Tyr Ser  Leu Gln Val 
    1025                 1030                 1035             


Thr Thr  Tyr Leu Asn Trp Leu  Val Arg Met Ser Ser  Glu Met Glu 
    1040                 1045                 1050             


Thr Asn  Ile Val Ala Val Glu  Arg Leu Lys Glu Tyr  Ser Glu Thr 
    1055                 1060                 1065             


Glu Lys  Glu Ala Pro Trp Gln  Ile Gln Glu Thr Ala  Pro Pro Ser 
    1070                 1075                 1080             


Asn Trp  Pro Gln Val Gly Arg  Val Glu Phe Arg Asn  Tyr Cys Leu 
    1085                 1090                 1095             


Arg Tyr  Arg Glu Asp Leu Asp  Phe Val Leu Arg His  Ile Asn Val 
    1100                 1105                 1110             


Thr Ile  Asn Gly Gly Glu Lys  Val Gly Ile Val Gly  Arg Thr Gly 
    1115                 1120                 1125             


Ala Gly  Lys Ser Ser Leu Thr  Leu Gly Leu Phe Arg  Ile Asn Glu 
    1130                 1135                 1140             


Ser Ala  Glu Gly Glu Ile Ile  Ile Asp Gly Ile Asn  Ile Ala Arg 
    1145                 1150                 1155             


Ile Gly  Leu His Asp Leu Arg  Phe Lys Ile Thr Ile  Ile Pro Gln 
    1160                 1165                 1170             


Asp Pro  Val Leu Phe Ser Gly  Ser Leu Arg Met Asn  Leu Asp Pro 
    1175                 1180                 1185             


Phe Ser  Gln Tyr Ser Asp Glu  Glu Val Trp Thr Ser  Leu Glu Leu 
    1190                 1195                 1200             


Ala His  Leu Lys Gly Phe Val  Ser Ala Leu Pro Asp  Lys Leu Asp 
    1205                 1210                 1215             


His Glu  Cys Ala Glu Gly Gly  Glu Asn Leu Ser Val  Gly Gln Arg 
    1220                 1225                 1230             


Gln Leu  Val Cys Leu Ala Arg  Ala Leu Leu Arg Lys  Thr Lys Ile 
    1235                 1240                 1245             


Leu Val  Leu Asp Glu Ala Thr  Ala Ala Val Asp Leu  Glu Thr Asp 
    1250                 1255                 1260             


Asp Leu  Ile Gln Ser Thr Ile  Arg Thr Gln Phe Glu  Asp Cys Thr 
    1265                 1270                 1275             


Val Leu  Thr Ile Ala His Arg  Leu Asn Thr Ile Met  Asp Tyr Thr 
    1280                 1285                 1290             


Arg Val  Ile Val Leu Asp Lys  Gly Glu Ile Gln Glu  Tyr Gly Ala 
    1295                 1300                 1305             


Pro Ser  Asp Leu Leu Gln Gln  Arg Gly Leu Phe Tyr  Asn Met Ala 
    1310                 1315                 1320             


Arg Asp  Ala Gly Leu Val 
    1325                 


<210>  160
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  160

Gly Ser Gly Gly Ser 
1               5   


<210>  161
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  161

Gly Gly Gly Ser 
1               


<210>  162
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  162

Gly Gly Ser Gly 
1               


<210>  163
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  163

Gly Gly Ser Gly Gly 
1               5   


<210>  164
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  164

Gly Ser Gly Ser Gly 
1               5   


<210>  165
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  165

Gly Ser Gly Gly Gly 
1               5   


<210>  166
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  166

Gly Gly Gly Ser Gly 
1               5   


<210>  167
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  167

Gly Ser Ser Ser Gly 
1               5   


<210>  168
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (3)..(15)
<223>  Each amino acid at positions 3 to 15 is either present or absent

<400>  168

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15  


<210>  169
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  169

Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  170
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  170

Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   


<210>  171
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  171

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  172
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  172

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  173
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  173

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  174
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  174

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  175
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  175

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  176
<211>  240
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 


Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  177
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  177

Asp Thr Tyr Ile His 
1               5   


<210>  178
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  178

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  179
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  179

Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  180
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  180

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  181
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  181

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  182
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  183
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  183

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  184
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Cys 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Cys Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


