                               SEQUENCE LISTING

<110> GENOMATICA, INC.
 
<120> FLAVIN-DEPENDENT OXIDASES HAVING CANNABINOID SYNTHASE ACTIVITY

<130> 0171-0002WO1

<140>
<141>

<150> 63/138,109
<151> 2021-01-15

<150> 63/074,227
<151> 2020-09-03

<160> 25    

<170> PatentIn version 3.5

<210> 1
<211> 462
<212> PRT
<213> Streptomyces sp.

<400> 1
Met Gln Phe Pro Gln Leu Asp Pro Ala Thr Leu Ala Ala Phe Ser Ala 
1               5                   10                  15      


Ala Phe Arg Gly Glu Leu Ile Trp Pro Ser Asp Ala Asp Tyr Asp Glu 
            20                  25                  30          


Ala Arg Arg Ile Trp Asn Gly Thr Ile Asp Arg Arg Pro Ala Leu Ile 
        35                  40                  45              


Ala Arg Cys Thr Ser Thr Pro Asp Val Val Ala Ala Val Ser Phe Ala 
    50                  55                  60                  


Arg Lys Ser Gly Leu Leu Val Ala Val Arg Gly Gly Gly His Ser Met 
65                  70                  75                  80  


Ala Gly His Ser Val Cys Asp Gly Gly Ile Val Ile Asp Leu Ser Leu 
                85                  90                  95      


Met Asn Ser Ile Lys Val Ser Arg Arg Leu Arg Arg Ala Arg Ala Gln 
            100                 105                 110         


Gly Gly Cys Leu Leu Gly Ala Phe Asp Thr Ala Thr Gln Ala His Met 
        115                 120                 125             


Leu Ala Thr Pro Ala Gly Val Val Ser His Thr Gly Leu Gly Gly Leu 
    130                 135                 140                 


Val Leu Gly Gly Gly Phe Gly Trp Leu Ser Arg Lys Tyr Gly Leu Ser 
145                 150                 155                 160 


Ile Asp Asn Leu Thr Ser Val Glu Ile Val Thr Ala Asp Gly Gly Val 
                165                 170                 175     


Leu Thr Ala Ser Asp Thr Glu Asn Pro Asp Leu Phe Trp Ala Val Arg 
            180                 185                 190         


Gly Gly Gly Gly Asn Phe Gly Val Val Thr Ala Phe Glu Phe Asp Leu 
        195                 200                 205             


His Arg Val Gly Pro Val Arg Phe Ala Ser Thr Tyr Tyr Ser Leu Asp 
    210                 215                 220                 


Glu Gly Pro Gln Val Ile Arg Ala Trp Arg Asp His Met Ala Thr Ala 
225                 230                 235                 240 


Pro Asp Glu Leu Thr Trp Ala Leu Tyr Leu Arg Leu Ala Pro Pro Leu 
                245                 250                 255     


Pro Glu Leu Pro Ala Asp Met His Gly Lys Pro Val Ile Cys Ala Met 
            260                 265                 270         


Ser Cys Trp Ile Gly Asp Pro His Glu Gly Glu Arg Gln Leu Glu Ser 
        275                 280                 285             


Ile Leu His Ala Gly Lys Pro His Gly Leu Thr Lys Ala Thr Leu Pro 
    290                 295                 300                 


Tyr Arg Ala Leu Gln Ala Tyr Ser Phe Pro Gly Ala Val Val Pro Asp 
305                 310                 315                 320 


Arg Ile Tyr Thr Lys Ser Gly Tyr Leu Asn Glu Leu Ser Asp Glu Ala 
                325                 330                 335     


Thr Asp Thr Val Leu Glu His Ala Ala Asp Ile Ala Ser Pro Phe Thr 
            340                 345                 350         


Gln Leu Glu Leu Leu Tyr Leu Gly Gly Ala Val Ala Arg Val Pro Asp 
        355                 360                 365             


Asp Ala Thr Ala Tyr Pro Asn Arg Gln Ser Pro Phe Val Thr Asn Leu 
    370                 375                 380                 


Ala Ala Ala Trp Met Asp Pro Thr Glu Asp Ala Arg His Thr Ala Trp 
385                 390                 395                 400 


Ala Arg Glu Gly Tyr Arg Ala Leu Ala Gly His Leu Ser Gly Gly Tyr 
                405                 410                 415     


Val Asn Phe Met Asn Pro Gly Glu Ala Asp Arg Thr Arg Glu Ala Tyr 
            420                 425                 430         


Gly Ala Ala Lys Phe Glu Arg Leu Gln Gly Val Lys Ala Lys Tyr Asp 
        435                 440                 445             


Pro Thr Asn Leu Phe Arg Leu Asn Gln Asn Ile Pro Pro Ser 
    450                 455                 460         


<210> 2
<211> 462
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Gln Phe Pro Gln Leu Asp Pro Ala Thr Leu Ala Ala Phe Ser Ala 
1               5                   10                  15      


Ala Phe Arg Gly Glu Leu Ile Trp Pro Ser Asp Ala Asp Tyr Asp Glu 
            20                  25                  30          


Ala Arg Arg Ile Trp Asn Gly Thr Ile Asp Arg Arg Pro Ala Leu Ile 
        35                  40                  45              


Ala Arg Cys Thr Ser Thr Pro Asp Val Val Ala Ala Val Ser Phe Ala 
    50                  55                  60                  


Arg Lys Ser Gly Leu Leu Val Ala Val Arg Gly Gly Gly His Ser Met 
65                  70                  75                  80  


Ala Gly His Ser Val Cys Asp Gly Gly Ile Val Ile Asp Leu Ser Leu 
                85                  90                  95      


Met Asn Ser Ile Lys Val Ser Arg Arg Leu Arg Arg Ala Arg Ala Gln 
            100                 105                 110         


Gly Gly Cys Leu Leu Gly Ala Phe Asp Thr Ala Thr Gln Ala His Met 
        115                 120                 125             


Leu Ala Thr Pro Ala Gly Val Val Ser His Val Gly Leu Gly Gly Leu 
    130                 135                 140                 


Val Leu Gly Gly Gly Phe Gly Trp Leu Ser Arg Lys Tyr Gly Leu Ser 
145                 150                 155                 160 


Ile Asp Asn Leu Thr Ser Val Glu Ile Val Thr Ala Asp Gly Gly Val 
                165                 170                 175     


Leu Thr Ala Ser Asp Thr Glu Asn Pro Asp Leu Phe Trp Ala Val Arg 
            180                 185                 190         


Gly Gly Gly Gly Asn Phe Gly Val Val Thr Ala Phe Glu Phe Asp Leu 
        195                 200                 205             


His Arg Val Gly Pro Val Arg Phe Ala Ser Thr Tyr Tyr Ser Leu Asp 
    210                 215                 220                 


Glu Gly Pro Gln Val Ile Arg Ala Trp Arg Asp His Met Ala Thr Ala 
225                 230                 235                 240 


Pro Asp Glu Leu Thr Trp Ala Leu Tyr Leu Arg Leu Ala Pro Pro Leu 
                245                 250                 255     


Pro Glu Leu Pro Ala Asp Met His Gly Lys Pro Val Ile Cys Ala Met 
            260                 265                 270         


Ser Cys Trp Ile Gly Asp Pro His Glu Gly Glu Arg Gln Leu Glu Ser 
        275                 280                 285             


Ile Leu His Ala Gly Lys Pro His Gly Leu Thr Lys Ala Thr Leu Pro 
    290                 295                 300                 


Tyr Arg Ala Leu Gln Ala Tyr Ser Phe Pro Gly Ala Val Val Pro Asp 
305                 310                 315                 320 


Arg Ile Tyr Thr Lys Ser Gly Tyr Leu Asn Glu Leu Ser Asp Glu Ala 
                325                 330                 335     


Thr Asp Thr Val Leu Glu His Ala Ala Asp Ile Ala Ser Pro Phe Thr 
            340                 345                 350         


Gln Leu Glu Leu Leu Tyr Leu Gly Gly Ala Val Ala Arg Val Pro Asp 
        355                 360                 365             


Asp Ala Thr Ala Tyr Pro Asn Arg Gln Ser Pro Phe Val Thr Asn Leu 
    370                 375                 380                 


Ala Ala Ala Trp Met Asp Pro Thr Glu Asp Ala Arg His Thr Ala Trp 
385                 390                 395                 400 


Ala Arg Glu Gly Tyr Arg Ala Leu Ala Gly His Leu Ser Gly Gly Tyr 
                405                 410                 415     


Val Asn Phe Met Asn Pro Gly Glu Ala Asp Arg Thr Arg Glu Ala Tyr 
            420                 425                 430         


Gly Ala Ala Lys Phe Glu Arg Leu Gln Gly Val Lys Ala Lys Tyr Asp 
        435                 440                 445             


Pro Thr Asn Leu Phe Arg Leu Asn Gln Asn Ile Pro Pro Ser 
    450                 455                 460         


<210> 3
<211> 506
<212> PRT
<213> Streptomyces sp.

<400> 3
Met Thr Ala Asp Pro Ser Ser Glu Arg Ser Asp Met Asn Glu Ala Asp 
1               5                   10                  15      


Glu Val Asn Glu Val Asp Glu Leu Ser Glu Thr Gly Gln Thr Ser Gly 
            20                  25                  30          


Thr Lys Gly Lys Arg Pro Phe Thr Gly Arg Val Ile Gly Pro Ala Asp 
        35                  40                  45              


Gly Glu Phe Asp Glu Ala Arg Arg Val Trp Asn Glu Cys Phe Ala Ala 
    50                  55                  60                  


Arg Pro Lys Glu Ile Val Tyr Cys Ala Asp Thr Arg Asp Val Val Arg 
65                  70                  75                  80  


Ala Leu Arg Glu Val Arg Gln Arg Gly Gly Pro Phe Arg Val Arg Ser 
                85                  90                  95      


Gly Gly His Ser Met Ser Gly Leu Ser Val Leu Asp Asp Gly Thr Val 
            100                 105                 110         


Leu Asp Val Ser Gly Leu Asp Asp Ile Gln Val Ser Glu Asp Ala Ser 
        115                 120                 125             


Thr Val Thr Val Gly Ser Gly Ala His Leu Gly Asp Ile Phe Arg Ala 
    130                 135                 140                 


Leu Trp Ala Arg Gly Val Thr Val Pro Ala Gly Phe Cys Pro Glu Ile 
145                 150                 155                 160 


Gly Ile Ala Gly His Val Leu Gly Gly Gly Ala Gly Ile Leu Val Arg 
                165                 170                 175     


Ser Arg Gly Phe Leu Ser Asp His Leu Val Ala Leu Glu Met Val Asp 
            180                 185                 190         


Ser Glu Gly Arg Ile Val Val Ala Asp His Asp Ser His His Glu Leu 
        195                 200                 205             


Leu Trp Ala Ser Arg Gly Gly Gly Gly Gly Asn Phe Gly Ile Ala Thr 
    210                 215                 220                 


Ser Phe Thr Leu Arg Thr Gln Pro Ile Gly Asp Val Thr Leu Phe Thr 
225                 230                 235                 240 


Ile Ala Trp Asp Trp Asp Arg Gly Ala Glu Ala Ile Lys Ala Trp Gln 
                245                 250                 255     


Glu Trp Leu Ala Thr Ala Asp Gly Arg Ile Asn Thr Leu Phe Ile Ala 
            260                 265                 270         


Tyr Pro Gln Asp Gln Asp Met Phe Ala Ala Leu Gly Cys Phe Glu Gly 
        275                 280                 285             


Asp Ala Ala Glu Leu Glu Pro Leu Ile Ala Pro Leu Val His Ala Val 
    290                 295                 300                 


Glu Pro Thr Glu Lys Val Ala Glu Thr Met Pro Trp Ile Glu Ala Leu 
305                 310                 315                 320 


Ser Phe Val Glu Thr Met Gln Gly Glu Ala Met Lys Ala Thr Ser Val 
                325                 330                 335     


Arg Ala Lys Gly Asn Leu Ser Phe Val Thr Glu Pro Leu Gly Asp Arg 
            340                 345                 350         


Ala Val Glu Glu Ile Lys Lys Ala Leu Ala Gln Ala Pro Ser His Arg 
        355                 360                 365             


Ala Glu Val Val Leu Tyr Gly Leu Gly Gly Ala Val Ala Ala Lys Gly 
    370                 375                 380                 


Arg Arg Glu Thr Ala Phe Val His Arg Asp Ala Pro Val Ala Leu Asn 
385                 390                 395                 400 


Tyr His Thr Asp Trp Asp Asp Glu Ala Glu Asp Asp Leu Asn Phe Ala 
                405                 410                 415     


Trp Ile Gln Asn Leu Arg Ala Ser Val Ala Ala His Thr Glu Gly Arg 
            420                 425                 430         


Gly Ser Tyr Val Asn Thr Ile Asp Leu Thr Val Glu His Trp Leu Trp 
        435                 440                 445             


Asp Tyr Tyr Glu Glu Asn Leu Pro Arg Leu Met Ala Val Lys Lys Arg 
    450                 455                 460                 


Tyr Asp Pro Glu Asp Val Phe Arg His Pro Gln Ser Ile Pro Val Ser 
465                 470                 475                 480 


Leu Thr Glu Ala Glu Ala Ala Glu Leu Gly Ile Pro Pro His Ile Ala 
                485                 490                 495     


Glu Glu Leu Arg Ala Ala Arg Gln Leu Arg 
            500                 505     


<210> 4
<211> 480
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Gln Phe Pro Gln Leu Asp Pro Ala Thr Leu Ala Ala Phe 
            20                  25                  30          


Ser Ala Ala Phe Arg Gly Glu Leu Ile Trp Pro Ser Asp Ala Asp Tyr 
        35                  40                  45              


Asp Glu Ala Arg Arg Ile Trp Asn Gly Thr Ile Asp Arg Arg Pro Ala 
    50                  55                  60                  


Leu Ile Ala Arg Cys Thr Ser Thr Pro Asp Val Val Ala Ala Val Ser 
65                  70                  75                  80  


Phe Ala Arg Lys Ser Gly Leu Leu Val Ala Val Arg Gly Gly Gly His 
                85                  90                  95      


Ser Met Ala Gly His Ser Val Cys Asp Gly Gly Ile Val Ile Asp Leu 
            100                 105                 110         


Ser Leu Met Asn Ser Ile Lys Val Ser Arg Arg Leu Arg Arg Ala Arg 
        115                 120                 125             


Ala Gln Gly Gly Cys Leu Leu Gly Ala Phe Asp Thr Ala Thr Gln Ala 
    130                 135                 140                 


His Met Leu Ala Thr Pro Ala Gly Val Val Ser His Thr Gly Leu Gly 
145                 150                 155                 160 


Gly Leu Val Leu Gly Gly Gly Phe Gly Trp Leu Ser Arg Lys Tyr Gly 
                165                 170                 175     


Leu Ser Ile Asp Asn Leu Thr Ser Val Glu Ile Val Thr Ala Asp Gly 
            180                 185                 190         


Gly Val Leu Thr Ala Ser Asp Thr Glu Asn Pro Asp Leu Phe Trp Ala 
        195                 200                 205             


Val Arg Gly Gly Gly Gly Asn Phe Gly Val Val Thr Ala Phe Glu Phe 
    210                 215                 220                 


Asp Leu His Arg Val Gly Pro Val Arg Phe Ala Ser Thr Tyr Tyr Ser 
225                 230                 235                 240 


Leu Asp Glu Gly Pro Gln Val Ile Arg Ala Trp Arg Asp His Met Ala 
                245                 250                 255     


Thr Ala Pro Asp Glu Leu Thr Trp Ala Leu Tyr Leu Arg Leu Ala Pro 
            260                 265                 270         


Pro Leu Pro Glu Leu Pro Ala Asp Met His Gly Lys Pro Val Ile Cys 
        275                 280                 285             


Ala Met Ser Cys Trp Ile Gly Asp Pro His Glu Gly Glu Arg Gln Leu 
    290                 295                 300                 


Glu Ser Ile Leu His Ala Gly Lys Pro His Gly Leu Thr Lys Ala Thr 
305                 310                 315                 320 


Leu Pro Tyr Arg Ala Leu Gln Ala Tyr Ser Phe Pro Gly Ala Val Val 
                325                 330                 335     


Pro Asp Arg Ile Tyr Thr Lys Ser Gly Tyr Leu Asn Glu Leu Ser Asp 
            340                 345                 350         


Glu Ala Thr Asp Thr Val Leu Glu His Ala Ala Asp Ile Ala Ser Pro 
        355                 360                 365             


Phe Thr Gln Leu Glu Leu Leu Tyr Leu Gly Gly Ala Val Ala Arg Val 
    370                 375                 380                 


Pro Asp Asp Ala Thr Ala Tyr Pro Asn Arg Gln Ser Pro Phe Val Thr 
385                 390                 395                 400 


Asn Leu Ala Ala Ala Trp Met Asp Pro Thr Glu Asp Ala Arg His Thr 
                405                 410                 415     


Ala Trp Ala Arg Glu Gly Tyr Arg Ala Leu Ala Gly His Leu Ser Gly 
            420                 425                 430         


Gly Tyr Val Asn Phe Met Asn Pro Gly Glu Ala Asp Arg Thr Arg Glu 
        435                 440                 445             


Ala Tyr Gly Ala Ala Lys Phe Glu Arg Leu Gln Gly Val Lys Ala Lys 
    450                 455                 460                 


Tyr Asp Pro Thr Asn Leu Phe Arg Leu Asn Gln Asn Ile Pro Pro Ser 
465                 470                 475                 480 


<210> 5
<211> 480
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Gln Phe Pro Gln Leu Asp Pro Ala Thr Leu Ala Ala Phe 
            20                  25                  30          


Ser Ala Ala Phe Arg Gly Glu Leu Ile Trp Pro Ser Asp Ala Asp Tyr 
        35                  40                  45              


Asp Glu Ala Arg Arg Ile Trp Asn Gly Thr Ile Asp Arg Arg Pro Ala 
    50                  55                  60                  


Leu Ile Ala Arg Cys Thr Ser Thr Pro Asp Val Val Ala Ala Val Ser 
65                  70                  75                  80  


Phe Ala Arg Lys Ser Gly Leu Leu Val Ala Val Arg Gly Gly Gly His 
                85                  90                  95      


Ser Met Ala Gly His Ser Val Cys Asp Gly Gly Ile Val Ile Asp Leu 
            100                 105                 110         


Ser Leu Met Asn Ser Ile Lys Val Ser Arg Arg Leu Arg Arg Ala Arg 
        115                 120                 125             


Ala Gln Gly Gly Cys Leu Leu Gly Ala Phe Asp Thr Ala Thr Gln Ala 
    130                 135                 140                 


His Met Leu Ala Thr Pro Ala Gly Val Val Ser His Val Gly Leu Gly 
145                 150                 155                 160 


Gly Leu Val Leu Gly Gly Gly Phe Gly Trp Leu Ser Arg Lys Tyr Gly 
                165                 170                 175     


Leu Ser Ile Asp Asn Leu Thr Ser Val Glu Ile Val Thr Ala Asp Gly 
            180                 185                 190         


Gly Val Leu Thr Ala Ser Asp Thr Glu Asn Pro Asp Leu Phe Trp Ala 
        195                 200                 205             


Val Arg Gly Gly Gly Gly Asn Phe Gly Val Val Thr Ala Phe Glu Phe 
    210                 215                 220                 


Asp Leu His Arg Val Gly Pro Val Arg Phe Ala Ser Thr Tyr Tyr Ser 
225                 230                 235                 240 


Leu Asp Glu Gly Pro Gln Val Ile Arg Ala Trp Arg Asp His Met Ala 
                245                 250                 255     


Thr Ala Pro Asp Glu Leu Thr Trp Ala Leu Tyr Leu Arg Leu Ala Pro 
            260                 265                 270         


Pro Leu Pro Glu Leu Pro Ala Asp Met His Gly Lys Pro Val Ile Cys 
        275                 280                 285             


Ala Met Ser Cys Trp Ile Gly Asp Pro His Glu Gly Glu Arg Gln Leu 
    290                 295                 300                 


Glu Ser Ile Leu His Ala Gly Lys Pro His Gly Leu Thr Lys Ala Thr 
305                 310                 315                 320 


Leu Pro Tyr Arg Ala Leu Gln Ala Tyr Ser Phe Pro Gly Ala Val Val 
                325                 330                 335     


Pro Asp Arg Ile Tyr Thr Lys Ser Gly Tyr Leu Asn Glu Leu Ser Asp 
            340                 345                 350         


Glu Ala Thr Asp Thr Val Leu Glu His Ala Ala Asp Ile Ala Ser Pro 
        355                 360                 365             


Phe Thr Gln Leu Glu Leu Leu Tyr Leu Gly Gly Ala Val Ala Arg Val 
    370                 375                 380                 


Pro Asp Asp Ala Thr Ala Tyr Pro Asn Arg Gln Ser Pro Phe Val Thr 
385                 390                 395                 400 


Asn Leu Ala Ala Ala Trp Met Asp Pro Thr Glu Asp Ala Arg His Thr 
                405                 410                 415     


Ala Trp Ala Arg Glu Gly Tyr Arg Ala Leu Ala Gly His Leu Ser Gly 
            420                 425                 430         


Gly Tyr Val Asn Phe Met Asn Pro Gly Glu Ala Asp Arg Thr Arg Glu 
        435                 440                 445             


Ala Tyr Gly Ala Ala Lys Phe Glu Arg Leu Gln Gly Val Lys Ala Lys 
    450                 455                 460                 


Tyr Asp Pro Thr Asn Leu Phe Arg Leu Asn Gln Asn Ile Pro Pro Ser 
465                 470                 475                 480 


<210> 6
<211> 909
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Gly Ser Ser His His His His His His Gly Ser Ser Gly Ala Ser 
1               5                   10                  15      


Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn 
            20                  25                  30          


Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys 
        35                  40                  45              


Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val 
    50                  55                  60                  


Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg 
65                  70                  75                  80  


Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp 
                85                  90                  95      


Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg 
            100                 105                 110         


Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser 
        115                 120                 125             


Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu 
    130                 135                 140                 


Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala 
145                 150                 155                 160 


Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala 
                165                 170                 175     


Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile 
            180                 185                 190         


Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe 
        195                 200                 205             


Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr 
    210                 215                 220                 


Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile 
225                 230                 235                 240 


Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr 
                245                 250                 255     


Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe 
            260                 265                 270         


Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu 
        275                 280                 285             


Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu 
    290                 295                 300                 


Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser 
305                 310                 315                 320 


Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu 
                325                 330                 335     


Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala 
            340                 345                 350         


Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg 
        355                 360                 365             


Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn Ser Ile Thr 
    370                 375                 380                 


Ser Leu Tyr Gly Ser Ser Gly Ser Ser Gly Ser Asn Leu Tyr Phe Gln 
385                 390                 395                 400 


Ser Asn Gly Met Thr Ala Asp Pro Ser Ser Glu Arg Ser Asp Met Asn 
                405                 410                 415     


Glu Ala Asp Glu Val Asn Glu Val Asp Glu Leu Ser Glu Thr Gly Gln 
            420                 425                 430         


Thr Ser Gly Thr Lys Gly Lys Arg Pro Phe Thr Gly Arg Val Ile Gly 
        435                 440                 445             


Pro Ala Asp Gly Glu Phe Asp Glu Ala Arg Arg Val Trp Asn Glu Cys 
    450                 455                 460                 


Phe Ala Ala Arg Pro Lys Glu Ile Val Tyr Cys Ala Asp Thr Arg Asp 
465                 470                 475                 480 


Val Val Arg Ala Leu Arg Glu Val Arg Gln Arg Gly Gly Pro Phe Arg 
                485                 490                 495     


Val Arg Ser Gly Gly His Ser Met Ser Gly Leu Ser Val Leu Asp Asp 
            500                 505                 510         


Gly Thr Val Leu Asp Val Ser Gly Leu Asp Asp Ile Gln Val Ser Glu 
        515                 520                 525             


Asp Ala Ser Thr Val Thr Val Gly Ser Gly Ala His Leu Gly Asp Ile 
    530                 535                 540                 


Phe Arg Ala Leu Trp Ala Arg Gly Val Thr Val Pro Ala Gly Phe Cys 
545                 550                 555                 560 


Pro Glu Ile Gly Ile Ala Gly His Val Leu Gly Gly Gly Ala Gly Ile 
                565                 570                 575     


Leu Val Arg Ser Arg Gly Phe Leu Ser Asp His Leu Val Ala Leu Glu 
            580                 585                 590         


Met Val Asp Ser Glu Gly Arg Ile Val Val Ala Asp His Asp Ser His 
        595                 600                 605             


His Glu Leu Leu Trp Ala Ser Arg Gly Gly Gly Gly Gly Asn Phe Gly 
    610                 615                 620                 


Ile Ala Thr Ser Phe Thr Leu Arg Thr Gln Pro Ile Gly Asp Val Thr 
625                 630                 635                 640 


Leu Phe Thr Ile Ala Trp Asp Trp Asp Arg Gly Ala Glu Ala Ile Lys 
                645                 650                 655     


Ala Trp Gln Glu Trp Leu Ala Thr Ala Asp Gly Arg Ile Asn Thr Leu 
            660                 665                 670         


Phe Ile Ala Tyr Pro Gln Asp Gln Asp Met Phe Ala Ala Leu Gly Cys 
        675                 680                 685             


Phe Glu Gly Asp Ala Ala Glu Leu Glu Pro Leu Ile Ala Pro Leu Val 
    690                 695                 700                 


His Ala Val Glu Pro Thr Glu Lys Val Ala Glu Thr Met Pro Trp Ile 
705                 710                 715                 720 


Glu Ala Leu Ser Phe Val Glu Thr Met Gln Gly Glu Ala Met Lys Ala 
                725                 730                 735     


Thr Ser Val Arg Ala Lys Gly Asn Leu Ser Phe Val Thr Glu Pro Leu 
            740                 745                 750         


Gly Asp Arg Ala Val Glu Glu Ile Lys Lys Ala Leu Ala Gln Ala Pro 
        755                 760                 765             


Ser His Arg Ala Glu Val Val Leu Tyr Gly Leu Gly Gly Ala Val Ala 
    770                 775                 780                 


Ala Lys Gly Arg Arg Glu Thr Ala Phe Val His Arg Asp Ala Pro Val 
785                 790                 795                 800 


Ala Leu Asn Tyr His Thr Asp Trp Asp Asp Glu Ala Glu Asp Asp Leu 
                805                 810                 815     


Asn Phe Ala Trp Ile Gln Asn Leu Arg Ala Ser Val Ala Ala His Thr 
            820                 825                 830         


Glu Gly Arg Gly Ser Tyr Val Asn Thr Ile Asp Leu Thr Val Glu His 
        835                 840                 845             


Trp Leu Trp Asp Tyr Tyr Glu Glu Asn Leu Pro Arg Leu Met Ala Val 
    850                 855                 860                 


Lys Lys Arg Tyr Asp Pro Glu Asp Val Phe Arg His Pro Gln Ser Ile 
865                 870                 875                 880 


Pro Val Ser Leu Thr Glu Ala Glu Ala Ala Glu Leu Gly Ile Pro Pro 
                885                 890                 895     


His Ile Ala Glu Glu Leu Arg Ala Ala Arg Gln Leu Arg 
            900                 905                 


<210> 7
<211> 385
<212> PRT
<213> Streptomyces antibioticus

<400> 7
Met Asn His Leu Arg Ala Glu Gly Pro Ala Ser Val Leu Ala Ile Gly 
1               5                   10                  15      


Thr Ala Asn Pro Glu Asn Ile Leu Leu Gln Asp Glu Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Phe Arg Val Thr Lys Ser Glu His Met Thr Gln Leu Lys Glu Lys 
        35                  40                  45              


Phe Arg Lys Ile Cys Asp Lys Ser Met Ile Arg Lys Arg Asn Cys Phe 
    50                  55                  60                  


Leu Asn Glu Glu His Leu Lys Gln Asn Pro Arg Leu Val Glu His Glu 
65                  70                  75                  80  


Met Gln Thr Leu Asp Ala Arg Gln Asp Met Leu Val Val Glu Val Pro 
                85                  90                  95      


Lys Leu Gly Lys Asp Ala Cys Ala Lys Ala Ile Lys Glu Trp Gly Gln 
            100                 105                 110         


Pro Lys Ser Lys Ile Thr His Leu Ile Phe Thr Ser Ala Ser Thr Thr 
        115                 120                 125             


Asp Met Pro Gly Ala Asp Tyr His Cys Ala Lys Leu Leu Gly Leu Ser 
    130                 135                 140                 


Pro Ser Val Lys Arg Val Met Met Tyr Gln Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Gly Thr Val Leu Arg Ile Ala Lys Asp Ile Ala Glu Asn Asn Lys Gly 
                165                 170                 175     


Ala Arg Val Leu Ala Val Cys Cys Asp Ile Met Ala Cys Leu Phe Arg 
            180                 185                 190         


Gly Pro Ser Glu Ser Asp Leu Glu Leu Leu Val Gly Gln Ala Ile Phe 
        195                 200                 205             


Gly Asp Gly Ala Ala Ala Val Ile Val Gly Ala Glu Pro Asp Glu Ser 
    210                 215                 220                 


Val Gly Glu Arg Pro Ile Phe Glu Leu Val Ser Thr Gly Gln Thr Ile 
225                 230                 235                 240 


Leu Pro Asn Ser Glu Gly Thr Ile Gly Gly His Ile Arg Glu Ala Gly 
                245                 250                 255     


Leu Ile Phe Asp Leu His Lys Asp Val Pro Met Leu Ile Ser Asn Asn 
            260                 265                 270         


Ile Glu Lys Cys Leu Ile Glu Ala Phe Thr Pro Ile Gly Ile Ser Asp 
        275                 280                 285             


Trp Asn Ser Ile Phe Trp Ile Thr His Pro Gly Gly Lys Ala Ile Leu 
    290                 295                 300                 


Asp Lys Val Glu Glu Lys Leu His Leu Lys Ser Asp Lys Phe Val Asp 
305                 310                 315                 320 


Ser Arg His Val Leu Ser Glu His Gly Asn Met Ser Ser Ser Thr Val 
                325                 330                 335     


Leu Phe Val Met Asp Glu Leu Arg Lys Arg Ser Leu Glu Glu Gly Lys 
            340                 345                 350         


Ser Thr Thr Gly Asp Gly Phe Glu Trp Gly Val Leu Phe Gly Phe Gly 
        355                 360                 365             


Pro Gly Leu Thr Val Glu Arg Val Val Val Arg Ser Val Pro Ile Lys 
    370                 375                 380                 


Tyr 
385 


<210> 8
<211> 101
<212> PRT
<213> Cannabis sativa

<400> 8
Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys 
            100     


<210> 9
<211> 305
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Prenyltransferase sequence

<400> 9
Met Ser Gly Ala Ala Asp Val Glu Arg Val Tyr Ala Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Gly Val Thr Cys Ala Arg Glu Lys Ile Tyr Pro 
            20                  25                  30          


Leu Leu Thr Glu Phe Gln Asp Thr Leu Thr Asp Gly Val Val Val Phe 
        35                  40                  45              


Ser Met Ala Ser Gly Arg Arg Ser Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Thr Ser Gln Gly Asp Pro Tyr Ala Thr Val Val Asp Lys Gly 
65                  70                  75                  80  


Leu Phe Pro Ala Thr Gly His Pro Val Asp Asp Leu Leu Ala Asp Thr 
                85                  90                  95      


Gln Lys His Leu Pro Val Ser Met Phe Ala Ile Asp Gly Glu Val Thr 
            100                 105                 110         


Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asp Met Pro 
        115                 120                 125             


Gly Val Ala Gln Leu Ser Ala Ile Pro Ser Met Pro Ser Ser Val Ala 
    130                 135                 140                 


Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Thr Ser Met Asp Tyr Lys Lys Arg Gln Val Asn Leu Tyr Phe Ser Glu 
                165                 170                 175     


Leu Ser Glu Gln Thr Leu Ala Pro Glu Ser Val Leu Ala Leu Val Arg 
            180                 185                 190         


Glu Leu Gly Leu His Val Pro Thr Glu Leu Gly Leu Glu Phe Cys Lys 
        195                 200                 205             


Arg Ser Phe Ser Val Tyr Pro Thr Leu Asn Trp Asp Thr Gly Lys Ile 
    210                 215                 220                 


Asp Arg Leu Cys Phe Ala Val Ile Ser Thr Asp Pro Thr Leu Val Pro 
225                 230                 235                 240 


Ser Thr Asp Glu Arg Asp Ile Glu Gln Phe Arg His Tyr Gly Thr Lys 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Val Gly Glu Asn Arg Thr Leu Val Tyr Gly Leu 
            260                 265                 270         


Thr Leu Ser Pro Thr Glu Glu Tyr Tyr Lys Leu Gly Ala Tyr Tyr His 
        275                 280                 285             


Ile Thr Asp Ile Gln Arg Arg Leu Leu Lys Ala Phe Asp Ala Leu Glu 
    290                 295                 300                 


Asp 
305 


<210> 10
<211> 542
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Gln Ala Cys Asn Asn His Gln Leu Thr Asp Ala Ile Leu Gln Glu 
1               5                   10                  15      


Phe Ser Gln Thr Leu Ser Gly Asp Leu Val Leu Pro Thr Asp Gly Leu 
            20                  25                  30          


Tyr Gln Trp Ala Arg Leu Ile His His Thr Asn Phe Asp Gly Ile Tyr 
        35                  40                  45              


Pro Val Gly Ile Val Phe Cys Glu Thr Pro Glu Asp Val Ser Lys Ala 
    50                  55                  60                  


Ile Leu Phe Ala Arg Gln Phe Gly Leu His Val Thr Ala Arg Gly Gly 
65                  70                  75                  80  


Gly His Ser Tyr Glu Gly Tyr Ser Val Thr Gly Gly Leu Leu Ile Asp 
                85                  90                  95      


Val Ser Arg Met Asn Ser Val Ser Val Asn Pro Ala Ala Met Thr Ala 
            100                 105                 110         


Val Val Gly Ala Gly Ala Val Leu Ile Asp Val Tyr His Gly Leu Tyr 
        115                 120                 125             


Tyr Pro His Lys Leu Ser Ile Pro Gly Gly Ser Cys Pro Ser Val Gly 
    130                 135                 140                 


Ile Ala Gly Tyr Leu Leu Gly Gly Gly Val Gly Leu Gln Ser Arg Thr 
145                 150                 155                 160 


Tyr Gly Val Gly Cys Asp Arg Val Leu Glu Ile Gly Val Val Leu Ala 
                165                 170                 175     


Ser Gly Glu Tyr Val Val Ala Ser Pro Thr Asn His Ser Asp Leu Tyr 
            180                 185                 190         


Trp Ala Tyr Arg Gly Gly Gly Gly Gly Asn Phe Gly Val Val Thr His 
        195                 200                 205             


Phe Lys Met Gln Cys His Pro Val Asp Arg Leu Ser Tyr Ala Ile Ile 
    210                 215                 220                 


Thr Trp Asp Trp Glu Ala Ala Ala Pro Ala Phe Asn Ala Trp Gln Asn 
225                 230                 235                 240 


Trp Leu Lys Gly Leu Gly Glu Asp Tyr Arg Asn Phe Ser Ile Phe Lys 
                245                 250                 255     


Phe Leu Val Asn Ala Gly Gly Asp Gly Gly Leu Gly Pro Lys Val Asn 
            260                 265                 270         


Leu Ile Val Gln Phe Asp Ser Gln Ser Asn Thr Gly Thr Gly Glu Leu 
        275                 280                 285             


Glu Thr Leu Met Ala Pro Leu Leu Asn Thr Ala His Glu His Ile Val 
    290                 295                 300                 


Ser Gln Thr Ile Met Asn Gly Asp Phe Phe Glu Val Thr Met Glu Ile 
305                 310                 315                 320 


Met Ala Gly Cys Ala Trp Pro Lys Thr Asp Leu Asp Thr Glu Phe Leu 
                325                 330                 335     


Arg Cys His Thr Val Gly Asn Pro Ala Phe Pro Met Ala Ser Leu Pro 
            340                 345                 350         


Arg Asp Thr Tyr Lys Ala Lys Ser Thr Phe Phe Ala Asp Val Ile Ser 
        355                 360                 365             


Glu Lys Gly Ile Glu Thr Cys Ile Lys Ala Ile Glu Asp Arg Phe Asn 
    370                 375                 380                 


Ser Asn Leu Pro Asp Asn Ser Ser Gln Phe Thr Cys Ala Leu Gln Phe 
385                 390                 395                 400 


Asp Ser Glu Gly Gly Ile Met Gly Asp Val Pro Lys Asp Ala Thr Ala 
                405                 410                 415     


Phe Met His Arg Asp Cys Leu Met His Cys Gln Tyr Leu Ala Tyr Trp 
            420                 425                 430         


Pro Ala Glu Gly Asp Ala Trp Phe Asp Asp Asn Pro Asp Tyr Ser Tyr 
        435                 440                 445             


Cys Asp Val Ser Asn Gly Ser Met Gln Trp Ile Ser Asp Ala Phe Asn 
    450                 455                 460                 


Val Leu Trp Pro Phe Gly Asn Gly His Ala Tyr Gln Asn Tyr Ile Asp 
465                 470                 475                 480 


Lys Glu Gln Pro Asn Trp Leu Tyr Ala Tyr Tyr Gly Glu Asn Val Glu 
                485                 490                 495     


Arg Leu Arg Thr Val Lys Ala Lys Tyr Asp Pro Asp Asn Ile Trp Lys 
            500                 505                 510         


Phe Glu Gln Ser Ile Pro Pro Ala Gln Gly Gly Ser Gly Gly Ser Gly 
        515                 520                 525             


Ser Gly Ser Gly Gly Ser Gly Ser His His His His His His 
    530                 535                 540         


<210> 11
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Lys His Ile Asp Ser Val Ala Pro Gly Asp Ile Arg Tyr 
            20                  25                  30          


Glu Asp Leu Arg Arg Gly Glu Asn Leu Arg Phe Val Gly Asp Pro Glu 
        35                  40                  45              


Glu Ile His Leu Val Gly Ser Ala Ala Glu Ile Glu Gln Val Leu Ser 
    50                  55                  60                  


Arg Ala Val Arg Ser Gly Lys Arg Val Ala Val Arg Ser Gly Gly His 
65                  70                  75                  80  


Cys Tyr Glu Asp Phe Val Ala Asn Ser Asp Val Arg Val Val Met Asp 
                85                  90                  95      


Met Ser Arg Leu Ser Ala Val Gly Phe Asp Glu Glu Arg Gly Ala Phe 
            100                 105                 110         


Ala Val Glu Ala Gly Ala Thr Leu Gly Ala Val Tyr Lys Thr Leu Phe 
        115                 120                 125             


Arg Val Trp Gly Val Thr Leu Pro Gly Gly Ala Cys Pro Asp Val Gly 
    130                 135                 140                 


Ala Gly Gly His Ile Leu Gly Gly Gly Tyr Gly Pro Leu Ser Arg Met 
145                 150                 155                 160 


His Gly Ser Ile Val Asp Tyr Leu His Ala Val Glu Val Val Val Val 
                165                 170                 175     


Asp Ala Ser Gly Asp Ala Arg Thr Val Ile Ala Thr Arg Glu Pro Ser 
            180                 185                 190         


Asp Pro Asn His Asp Leu Trp Trp Ala His Thr Gly Gly Gly Gly Gly 
        195                 200                 205             


Asn Phe Gly Val Val Val Arg Tyr Trp Leu Arg Thr Ala Glu Ala Asp 
    210                 215                 220                 


Val Pro Pro Glu Pro Gly Arg Leu Leu Pro Arg Pro Pro Ala Glu Val 
225                 230                 235                 240 


Leu Leu Asn Thr Thr Val Trp Pro Trp Glu Gly Leu Asp Glu Ala Ala 
                245                 250                 255     


Phe Ala Arg Leu Val Arg Asn His Gly Arg Trp Phe Glu Gln Asn Ser 
            260                 265                 270         


Gly Pro Asp Ser Pro Trp Cys Asp Leu Tyr Ser Val Leu Ala Leu Thr 
        275                 280                 285             


Arg Ser Gln Ser Gly Ala Leu Ala Met Thr Thr Gln Leu Asp Ala Thr 
    290                 295                 300                 


Gly Pro Asp Ala Glu Lys Arg Leu Glu Thr Tyr Leu Ala Ala Val Ser 
305                 310                 315                 320 


Glu Gly Val Gly Val Gln Pro His Ser Asp Thr Arg Arg Leu Pro Trp 
                325                 330                 335     


Leu His Ser Thr Arg Trp Pro Gly Ile Ala Gly Asp Gly Asp Met Thr 
            340                 345                 350         


Gly Arg Ala Lys Ile Lys Ala Ala Tyr Ala Arg Arg Ser Phe Asp Asp 
        355                 360                 365             


Arg Gln Ile Gly Thr Leu Tyr Thr Arg Leu Thr Ser Thr Asp Tyr Asp 
    370                 375                 380                 


Asn Pro Ala Gly Val Val Ala Leu Ile Ala Tyr Gly Gly Lys Val Asn 
385                 390                 395                 400 


Ala Val Pro Ala Asp Arg Thr Ala Val Ala Gln Arg Asp Ser Ile Leu 
                405                 410                 415     


Lys Ile Val Tyr Val Thr Thr Trp Glu Asp Pro Ala Gln Asp Pro Val 
            420                 425                 430         


His Val Arg Trp Ile Arg Glu Leu Tyr Arg Asp Val Tyr Ala Asp Thr 
        435                 440                 445             


Gly Gly Val Pro Val Pro Gly Gly Ala Ala Asp Gly Ala Tyr Val Asn 
    450                 455                 460                 


Tyr Pro Asp Val Asp Leu Ala Asp Glu Glu Trp Asn Thr Ser Gly Val 
465                 470                 475                 480 


Pro Trp Ser Glu Leu Tyr Tyr Lys Asp Ala Tyr Pro Arg Leu Gln Ala 
                485                 490                 495     


Val Lys Ala Arg Trp Asp Pro Arg Asn Val Phe Arg His Ala Leu Ser 
            500                 505                 510         


Val Arg Val Pro Pro Ala 
        515             


<210> 12
<211> 1443
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccag       60

ttcccgcagt tggaccctgc tactttagcc gcgttctccg cagctttccg cggcgaactg      120

atttggccat ccgatgcaga ctacgatgaa gcgcgccgta tctggaacgg tactatcgac      180

cgccgtccgg ctctcatcgc gcgctgtact agcaccccgg acgtggttgc tgcggtttcc      240

ttcgcgcgca aatctggcct gcttgtggcg gttcgtggcg gtggccactc tatggctggt      300

cactcggtat gcgacggtgg cattgtgatt gacctgtctc tgatgaactc catcaaagta      360

tcccgccgtc tgcgccgtgc tcgtgcgcag ggtggctgcc tgctcggtgc tttcgacact      420

gctacccagg cgcatatgct cgcgaccccg gctggcgtcg tttcccacac cggcctgggc      480

ggtctggttc tgggtggcgg tttcggctgg ctgtcacgta aatatggcct gagcatcgac      540

aacctgacct ctgtagaaat cgtgaccgct gacggtggcg tgctgaccgc atccgatact      600

gagaacccgg acttattctg ggctgttcgc ggaggaggag gtaattttgg cgtcgtaacc      660

gctttcgaat tcgacttaca ccgcgtcggc ccagttcgtt tcgcatcgac ctactatagc      720

ctcgatgaag gcccgcaggt catccgtgct tggcgtgacc acatggcgac ggcaccggat      780

gaactgacct gggcgctcta tctgcgtctg gcgccgccac tgccggaact gcctgcagac      840

atgcacggca aaccggttat ctgcgcaatg tcttgctgga ttggtgaccc acatgaaggt      900

gaacgtcagt tagaatctat tctgcatgcc ggtaaaccgc acggcctgac taaagcgacc      960

cttccgtacc gcgcactgca ggcctattcc ttcccgggcg cagtcgttcc ggaccgtatc     1020

tacactaaat ccgggtacct gaatgagctg tccgacgagg cgaccgatac cgtgcttgaa     1080

cacgcagcgg atatcgcgtc gccgttcact caacttgaac tgctctacct gggcggtgcc     1140

gttgctcgtg ttccagatga cgcgaccgct tatcctaacc gccagtctcc gtttgtgacc     1200

aacctggcgg cagcttggat ggatccgacc gaggatgctc gtcacaccgc ttgggcgcgc     1260

gaaggttacc gtgcgctggc gggccatctg tccggtggct acgttaactt tatgaacccg     1320

ggtgaggcgg accgtacccg tgaagcctac ggcgcggcaa aatttgagcg cctgcagggc     1380

gtgaaagcta aatatgaccc gactaacctg ttccgtctga atcagaacat tccgccatcc     1440

tag                                                                   1443


<210> 13
<211> 1443
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccag       60

ttcccgcagt tggaccctgc tactttagcc gcgttctccg cagctttccg cggcgaactg      120

atttggccat ccgatgcaga ctacgatgaa gcgcgccgta tctggaacgg tactatcgac      180

cgccgtccgg ctctcatcgc gcgctgtact agcaccccgg acgtggttgc tgcggtttcc      240

ttcgcgcgca aatctggcct gcttgtggcg gttcgtggcg gtggccactc tatggctggt      300

cactcggtat gcgacggtgg cattgtgatt gacctgtctc tgatgaactc catcaaagta      360

tcccgccgtc tgcgccgtgc tcgtgcgcag ggtggctgcc tgctcggtgc tttcgacact      420

gctacccagg cgcatatgct cgcgaccccg gctggcgtcg tttcccacgt gggcctgggc      480

ggtctggttc tgggtggcgg tttcggctgg ctgtcacgta aatatggcct gagcatcgac      540

aacctgacct ctgtagaaat cgtgaccgct gacggtggcg tgctgaccgc atccgatact      600

gagaacccgg acttattctg ggctgttcgc ggaggaggag gtaattttgg cgtcgtaacc      660

gctttcgaat tcgacttaca ccgcgtcggc ccagttcgtt tcgcatcgac ctactatagc      720

ctcgatgaag gcccgcaggt catccgtgct tggcgtgacc acatggcgac ggcaccggat      780

gaactgacct gggcgctcta tctgcgtctg gcgccgccac tgccggaact gcctgcagac      840

atgcacggca aaccggttat ctgcgcaatg tcttgctgga ttggtgaccc acatgaaggt      900

gaacgtcagt tagaatctat tctgcatgcc ggtaaaccgc acggcctgac taaagcgacc      960

cttccgtacc gcgcactgca ggcctattcc ttcccgggcg cagtcgttcc ggaccgtatc     1020

tacactaaat ccgggtacct gaatgagctg tccgacgagg cgaccgatac cgtgcttgaa     1080

cacgcagcgg atatcgcgtc gccgttcact caacttgaac tgctctacct gggcggtgcc     1140

gttgctcgtg ttccagatga cgcgaccgct tatcctaacc gccagtctcc gtttgtgacc     1200

aacctggcgg cagcttggat ggatccgacc gaggatgctc gtcacaccgc ttgggcgcgc     1260

gaaggttacc gtgcgctggc gggccatctg tccggtggct acgttaactt tatgaacccg     1320

ggtgaggcgg accgtacccg tgaagcctac ggcgcggcaa aatttgagcg cctgcagggc     1380

gtgaaagcta aatatgaccc gactaacctg ttccgtctga atcagaacat tccgccatcc     1440

tag                                                                   1443


<210> 14
<211> 1521
<212> DNA
<213> Streptomyces sp.

<400> 14
atgaccgcag atccgagcag cgaacgtagc gatatgaatg aagcagatga agtgaacgaa       60

gttgatgaac tgagcgaaac cggtcagacc agcggcacca aaggtaaacg tccgtttaca      120

ggtcgtgtta ttggtccggc agatggtgaa tttgatgaag cacgtcgtgt ttggaatgaa      180

tgttttgcag cacgtccgaa agaaattgtt tattgtgcag atacccgtga tgttgttcgt      240

gcactgcgtg aagttcgtca gcgtggtggt ccgtttcgtg ttcgtagcgg tggtcatagc      300

atgagcggtc tgagcgttct ggatgatggt acagtgctgg atgttagtgg cctggatgat      360

attcaggtta gcgaagatgc aagcaccgtt accgttggta gcggtgcaca tctgggtgat      420

atttttcgtg ccctgtgggc acgtggtgtt accgttccgg caggtttttg tccggaaatt      480

ggtattgcag gtcatgtttt aggtggtggt gcaggtattc tggtgcgtag ccgtggtttt      540

ctgagcgatc atctggttgc actggaaatg gttgatagcg aaggtcgtat tgttgttgca      600

gatcatgata gtcatcatga actgctgtgg gcaagccgtg gtggtggcgg tggtaatttt      660

ggcattgcaa ccagctttac cctgcgtacc cagccgattg gtgatgttac cctgtttacc      720

attgcatggg attgggatcg tggtgccgaa gcaattaaag catggcaaga atggctggca      780

accgcagatg gtcgcattaa tacactgttt attgcatatc cgcaggacca ggatatgttt      840

gcagccctgg gttgttttga aggtgatgca gcagaactgg aaccgctgat tgcaccgctg      900

gttcatgcag ttgaaccgac cgaaaaagtt gcagaaacca tgccgtggat tgaagcactg      960

agctttgttg aaacaatgca gggtgaagcc atgaaagcaa ccagcgttcg tgcaaaaggt     1020

aatctgagtt ttgttaccga accgctgggt gatcgtgccg ttgaagaaat caaaaaagca     1080

ctggcacagg caccgagcca tcgtgccgaa gttgttctgt atggtttagg tggcgcagtt     1140

gcagcaaaag gtcgtcgtga aaccgcattt gttcatcgtg atgcaccggt tgcgctgaat     1200

tatcataccg attgggatga tgaagccgaa gatgatctga attttgcctg gattcagaat     1260

ctgcgtgcaa gcgttgcagc acataccgaa ggtcgcggta gctatgttaa taccattgat     1320

ctgaccgttg aacattggct gtgggattat tatgaagaaa atctgcctcg tctgatggcc     1380

gtgaaaaaac gttatgatcc ggaagatgtt tttcgtcatc cgcagagcat tccggttagc     1440

ctgaccgaag cagaagcagc cgaactgggt attccgcctc atattgccga agaactgcgt     1500

gccgcacgtc agctgcgtta g                                               1521


<210> 15
<211> 2730
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atgggtagca gccatcacca tcatcatcat ggtagcagcg gtgcaagcga agaaggcaaa       60

ctggttattt ggattaatgg cgataaaggc tataatggtc tggcagaagt tggcaaaaaa      120

ttcgaaaaag ataccggcat taaagtgacc gttgaacatc cggataaact ggaagaaaaa      180

tttccgcagg ttgcagcaac cggtgatggt ccggatatta tcttttgggc acatgatcgt      240

tttggtggtt atgcacagag cggtctgctg gcagaaatta caccggataa agcatttcag      300

gacaaactgt atccgtttac ctgggatgca gttcgctata acggtaaact gattgcatat      360

ccgattgcag ttgaagcact gagcctgatc tataacaaag atctgctgcc gaatccgcct      420

aaaacctggg aagaaattcc ggcactggat aaagaactga aagcaaaagg taaaagcgca      480

ctgatgttta atctgcaaga accgtatttt acctggcctc tgattgcagc agatggtggc      540

tatgcattca aatatgaaaa cggcaaatac gatatcaagg atgttggtgt tgataatgcg      600

ggtgcaaaag ccggtctgac ctttctggtt gatctgatca aaaacaaaca catgaatgcc      660

gataccgatt atagcattgc agaagcagca tttaacaaag gtgaaaccgc aatgacaatt      720

aatggtccgt gggcatggtc aaatattgat accagcaaag tgaattatgg tgttaccgtt      780

ctgccgacat ttaaaggtca gccgagcaaa ccgtttgttg gtgtgctgag cgcaggtatt      840

aatgcagcaa gcccgaacaa agaactggca aaagaatttc tggaaaacta tctgctgacc      900

gatgaaggtc tggaagcagt gaataaagat aaaccgctgg gtgcagttgc actgaaaagc      960

tatgaagagg aattagcaaa agatccgcgt attgcagcca ccatggaaaa tgcacagaaa     1020

ggcgaaatta tgccgaatat tccgcagatg agcgcatttt ggtatgccgt tcgtaccgca     1080

gtgattaatg ccgcatcagg tcgtcagacc gttgatgaag ccctgaaaga tgcccagacc     1140

aatagcatta ccagcctgta tggtagcagc ggtagctcag gtagcaatct gtattttcag     1200

agcaatggca tgaccgcaga tccgagcagc gaacgtagcg atatgaatga agcagatgaa     1260

gtgaacgaag ttgatgaact gagcgaaacc ggtcagacca gcggcaccaa aggtaaacgt     1320

ccgtttacag gtcgtgttat tggtccggca gatggtgaat ttgatgaagc acgtcgtgtt     1380

tggaatgaat gttttgcagc acgtccgaaa gaaattgttt attgtgcaga tacccgtgat     1440

gttgttcgtg cactgcgtga agttcgtcag cgtggtggtc cgtttcgtgt tcgtagcggt     1500

ggtcatagca tgagcggtct gagcgttctg gatgatggta cagtgctgga tgttagtggc     1560

ctggatgata ttcaggttag cgaagatgca agcaccgtta ccgttggtag cggtgcacat     1620

ctgggtgata tttttcgtgc cctgtgggca cgtggtgtta ccgttccggc aggtttttgt     1680

ccggaaattg gtattgcagg tcatgtttta ggtggtggtg caggtattct ggtgcgtagc     1740

cgtggttttc tgagcgatca tctggttgca ctggaaatgg ttgatagcga aggtcgtatt     1800

gttgttgcag atcatgatag tcatcatgaa ctgctgtggg caagccgtgg tggtggcggt     1860

ggtaattttg gcattgcaac cagctttacc ctgcgtaccc agccgattgg tgatgttacc     1920

ctgtttacca ttgcatggga ttgggatcgt ggtgccgaag caattaaagc atggcaagaa     1980

tggctggcaa ccgcagatgg tcgcattaat acactgttta ttgcatatcc gcaggaccag     2040

gatatgtttg cagccctggg ttgttttgaa ggtgatgcag cagaactgga accgctgatt     2100

gcaccgctgg ttcatgcagt tgaaccgacc gaaaaagttg cagaaaccat gccgtggatt     2160

gaagcactga gctttgttga aacaatgcag ggtgaagcca tgaaagcaac cagcgttcgt     2220

gcaaaaggta atctgagttt tgttaccgaa ccgctgggtg atcgtgccgt tgaagaaatc     2280

aaaaaagcac tggcacaggc accgagccat cgtgccgaag ttgttctgta tggtttaggt     2340

ggcgcagttg cagcaaaagg tcgtcgtgaa accgcatttg ttcatcgtga tgcaccggtt     2400

gcgctgaatt atcataccga ttgggatgat gaagccgaag atgatctgaa ttttgcctgg     2460

attcagaatc tgcgtgcaag cgttgcagca cataccgaag gtcgcggtag ctatgttaat     2520

accattgatc tgaccgttga acattggctg tgggattatt atgaagaaaa tctgcctcgt     2580

ctgatggccg tgaaaaaacg ttatgatccg gaagatgttt ttcgtcatcc gcagagcatt     2640

ccggttagcc tgaccgaagc agaagcagcc gaactgggta ttccgcctca tattgccgaa     2700

gaactgcgtg ccgcacgtca gctgcgttag                                      2730


<210> 16
<211> 1626
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
atgcaggcat gtaataatca tcagctgacc gatgcaatcc tgcaagaatt ttcacagacc       60

ctgagcggtg atctggttct gccgaccgat ggtctgtatc agtgggcacg tctgattcat      120

cataccaatt ttgatggtat ttatccggtg ggcattgtgt tttgtgaaac accggaagat      180

gttagcaaag caattctgtt tgcacgtcag tttggtctgc atgttaccgc acgtggtggt      240

ggtcatagtt atgaaggtta tagcgttacc ggtggtctgc tgattgatgt tagccgtatg      300

aatagcgtta gcgttaatcc ggcagcaatg accgcagttg ttggtgccgg tgcagttctg      360

atcgatgttt atcatggcct gtattatccg cacaaactga gcattccagg tggtagctgt      420

ccgagcgttg gtattgcagg ttatctgctt ggtggtggcg tgggtctgca gagccgtacc      480

tatggtgttg gttgtgatcg tgttctggaa attggtgttg ttctggcaag cggtgaatat      540

gttgttgcaa gcccgaccaa tcatagcgat ctgtattggg catatcgtgg tggcggtggt      600

ggtaattttg gtgtggttac ccactttaaa atgcagtgtc atccggttga tcgtctgagc      660

tatgcaatta ttacctggga ttgggaagca gcagcaccgg catttaatgc atggcagaat      720

tggctgaaag gtctgggtga agattatcgc aatttctcga tctttaagtt cctggttaat      780

gcaggcggtg atggtggtct gggtccgaaa gttaatctga ttgttcagtt tgatagccag      840

agcaataccg gcaccggtga actggaaacc ctgatggcac cgctgctgaa taccgcacat      900

gaacatattg ttagccagac cattatgaac ggcgattttt ttgaagtgac catggaaatt      960

atggcaggtt gtgcatggcc gaaaaccgat ctggataccg aatttctgcg ttgtcatacc     1020

gttggcaatc cggcatttcc gatggcaagc ctgcctcgtg atacctataa agcaaaaagc     1080

accttttttg ccgatgtgat tagcgaaaaa ggtatcgaaa cctgcatcaa agccattgaa     1140

gatcgcttta atagcaatct gccggataat agcagccagt ttacctgtgc actgcagttc     1200

gatagcgaag gtggtattat gggtgatgtt ccgaaagatg caaccgcatt tatgcatcgt     1260

gattgtctga tgcattgtca gtatctggca tattggcctg ccgaaggtga tgcatggttt     1320

gatgataacc cggattatag ctattgtgat gtgagcaatg gtagcatgca gtggattagt     1380

gatgccttta atgttctgtg gccgtttggt aatggtcatg catatcagaa ctatatcgat     1440

aaagaacagc cgaactggct gtatgcatat tatggtgaaa atgttgaacg tctgcgtacc     1500

gtgaaagcaa aatatgatcc ggataacatc tggaagtttg aacagagcat tccgcctgca     1560

tagggcggta gcggaggatc tggtagtggc tctggaggat ctggtagtca ccatcatcat     1620

caccat                                                                1626


<210> 17
<211> 1557
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagcaaa       60

cacattgact cggttgcgcc gggagacatc cgttacgagg atttgcgccg cggtgaaaac      120

ttacgtttcg ttggtgatcc agaggaaatt cacttggtcg gttcggcagc ggaaattgaa      180

caggttctta gtcgcgcggt gcgcagtggg aaacgtgtcg cggtacgctc tggcgggcat      240

tgctacgaag attttgttgc gaacagcgac gtgcgcgtgg ttatggatat gtcccgctta      300

agcgcagtgg gctttgacga ggagcgcggc gcttttgccg tagaggctgg ggccacgctg      360

ggcgcagtat acaagacctt gtttcgcgta tggggagtga ctctgccagg tggcgcctgt      420

cctgatgtag gcgctggcgg acatatcctt ggcggtggat atggtccttt gtcacgcatg      480

catgggtcga tcgtcgatta tcttcacgct gttgaggtgg tcgtcgtcga cgcttctgga      540

gacgcccgta ctgtaatcgc tacccgcgag ccgagcgacc ctaaccacga tttatggtgg      600

gcgcacactg gaggtggtgg tgggaacttc ggggtagtcg tacgctactg gcttcgtaca      660

gcggaggccg acgtacctcc ggagcctggg cgcctgttgc cccgtccacc agctgaagtc      720

ttgctgaata ctacagtgtg gccctgggag ggattagacg aggccgcgtt tgctcgtctg      780

gtgcgtaatc acggccgttg gttcgaacaa aactcgggac ctgattcgcc ttggtgtgac      840

ctttatagtg tcttagcgtt gacccgctca cagtccggtg cgttagctat gacaactcag      900

cttgacgcaa cgggacctga cgccgaaaaa cgtcttgaga catatcttgc ggctgttagc      960

gaaggcgttg gggttcagcc ccattccgat acacgccgct tgccctggtt gcattcgaca     1020

cgctggccag gcatcgccgg cgatggcgac atgacgggac gtgcgaagat taaggctgcc     1080

tatgcccgtc gcagttttga cgatcgccaa attggcacat tatacacacg tctgacgagc     1140

accgattatg ataaccctgc tggagtcgtg gctctgattg cttatggcgg aaaagtcaac     1200

gcagtacctg ccgaccgtac tgccgtagcg cagcgcgatt ccattctgaa gattgtatat     1260

gttacgactt gggaagaccc cgctcaagat cctgtgcatg tgcgttggat ccgcgagtta     1320

taccgtgacg tttacgccga cacggggggt gtgcctgttc ctgggggtgc ggccgatgga     1380

gcttacgtta actaccccga cgtggatttg gcggacgagg aatggaatac ttcgggggtc     1440

ccgtggagcg agttatatta caaggatgcc tatcctcgtc tgcaagctgt gaaagcacgc     1500

tgggacccgc gcaacgtttt ccgtcacgct ttgtctgtcc gtgtcccgcc agcttag        1557


<210> 18
<211> 525
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Lys His His His His His His His His Gly Gly Leu Val Pro Arg 
1               5                   10                  15      


Gly Ser His Gly Thr Ala Asp Pro Ser Ser Glu Arg Ser Asp Met Asn 
            20                  25                  30          


Glu Ala Asp Glu Val Asn Glu Val Asp Glu Leu Ser Glu Thr Gly Gln 
        35                  40                  45              


Thr Ser Gly Thr Lys Gly Lys Arg Pro Phe Thr Gly Arg Val Ile Gly 
    50                  55                  60                  


Pro Ala Asp Gly Glu Phe Asp Glu Ala Arg Arg Val Trp Asn Glu Cys 
65                  70                  75                  80  


Phe Ala Ala Arg Pro Lys Glu Ile Val Tyr Cys Ala Asp Thr Arg Asp 
                85                  90                  95      


Val Val Arg Ala Leu Arg Glu Val Arg Gln Arg Gly Gly Pro Phe Arg 
            100                 105                 110         


Val Arg Ser Gly Gly His Ser Met Ser Gly Leu Ser Val Leu Asp Asp 
        115                 120                 125             


Gly Thr Val Leu Asp Val Ser Gly Leu Asp Asp Ile Gln Val Ser Glu 
    130                 135                 140                 


Asp Ala Ser Thr Val Thr Val Gly Ser Gly Ala His Leu Gly Asp Ile 
145                 150                 155                 160 


Phe Arg Ala Leu Trp Ala Arg Gly Val Thr Val Pro Ala Gly Phe Cys 
                165                 170                 175     


Pro Glu Ile Gly Ile Ala Gly His Val Leu Gly Gly Gly Ala Gly Ile 
            180                 185                 190         


Leu Val Arg Ser Arg Gly Phe Leu Ser Asp His Leu Val Ala Leu Glu 
        195                 200                 205             


Met Val Asp Ser Glu Gly Arg Ile Val Val Ala Asp His Asp Ser His 
    210                 215                 220                 


His Glu Leu Leu Trp Ala Ser Arg Gly Gly Gly Gly Gly Asn Phe Gly 
225                 230                 235                 240 


Ile Ala Thr Ser Phe Thr Leu Arg Thr Gln Pro Ile Gly Asp Val Thr 
                245                 250                 255     


Leu Phe Thr Ile Ala Trp Asp Trp Asp Arg Gly Ala Glu Ala Ile Lys 
            260                 265                 270         


Ala Trp Gln Glu Trp Leu Ala Thr Ala Asp Gly Arg Ile Asn Thr Leu 
        275                 280                 285             


Phe Ile Ala Tyr Pro Gln Asp Gln Asp Met Phe Ala Ala Leu Gly Cys 
    290                 295                 300                 


Phe Glu Gly Asp Ala Ala Glu Leu Glu Pro Leu Ile Ala Pro Leu Val 
305                 310                 315                 320 


His Ala Val Glu Pro Thr Glu Lys Val Ala Glu Thr Met Pro Trp Ile 
                325                 330                 335     


Glu Ala Leu Ser Phe Val Glu Thr Met Gln Gly Glu Ala Met Lys Ala 
            340                 345                 350         


Thr Ser Val Arg Ala Lys Gly Asn Leu Ser Phe Val Thr Glu Pro Leu 
        355                 360                 365             


Gly Asp Arg Ala Val Glu Glu Ile Lys Lys Ala Leu Ala Gln Ala Pro 
    370                 375                 380                 


Ser His Arg Ala Glu Val Val Leu Tyr Gly Leu Gly Gly Ala Val Ala 
385                 390                 395                 400 


Ala Lys Gly Arg Arg Glu Thr Ala Phe Val His Arg Asp Ala Pro Val 
                405                 410                 415     


Ala Leu Asn Tyr His Thr Asp Trp Asp Asp Glu Ala Glu Asp Asp Leu 
            420                 425                 430         


Asn Phe Ala Trp Ile Gln Asn Leu Arg Ala Ser Val Ala Ala His Thr 
        435                 440                 445             


Glu Gly Arg Gly Ser Tyr Val Asn Thr Ile Asp Leu Thr Val Glu His 
    450                 455                 460                 


Trp Leu Trp Asp Tyr Tyr Glu Glu Asn Leu Pro Arg Leu Met Ala Val 
465                 470                 475                 480 


Lys Lys Arg Tyr Asp Pro Glu Asp Val Phe Arg His Pro Gln Ser Ile 
                485                 490                 495     


Pro Val Ser Leu Thr Glu Ala Glu Ala Ala Glu Leu Gly Ile Pro Pro 
            500                 505                 510         


His Ile Ala Glu Glu Leu Arg Ala Ala Arg Gln Leu Arg 
        515                 520                 525 


<210> 19
<211> 492
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Ala Asp Glu Val Asn Glu Val Asp Glu Leu Ser Glu Thr Gly Gln Thr 
1               5                   10                  15      


Ser Gly Thr Lys Gly Lys Arg Pro Phe Thr Gly Arg Val Ile Gly Pro 
            20                  25                  30          


Ala Asp Gly Glu Phe Asp Glu Ala Arg Arg Val Trp Asn Glu Cys Phe 
        35                  40                  45              


Ala Ala Arg Pro Lys Glu Ile Val Tyr Cys Ala Asp Thr Arg Asp Val 
    50                  55                  60                  


Val Arg Ala Leu Arg Glu Val Arg Gln Arg Gly Gly Pro Phe Arg Val 
65                  70                  75                  80  


Arg Ser Gly Gly His Ser Met Ser Gly Leu Ser Val Leu Asp Asp Gly 
                85                  90                  95      


Thr Val Leu Asp Val Ser Gly Leu Asp Asp Ile Gln Val Ser Glu Asp 
            100                 105                 110         


Ala Ser Thr Val Thr Val Gly Ser Gly Ala His Leu Gly Asp Ile Phe 
        115                 120                 125             


Arg Ala Leu Trp Ala Arg Gly Val Thr Val Pro Ala Gly Phe Cys Pro 
    130                 135                 140                 


Glu Ile Gly Ile Ala Gly His Val Leu Gly Gly Gly Ala Gly Ile Leu 
145                 150                 155                 160 


Val Arg Ser Arg Gly Phe Leu Ser Asp His Leu Val Ala Leu Glu Met 
                165                 170                 175     


Val Asp Ser Glu Gly Arg Ile Val Val Ala Asp His Asp Ser His His 
            180                 185                 190         


Glu Leu Leu Trp Ala Ser Arg Gly Gly Gly Gly Gly Asn Phe Gly Ile 
        195                 200                 205             


Ala Thr Ser Phe Thr Leu Arg Thr Gln Pro Ile Gly Asp Val Thr Leu 
    210                 215                 220                 


Phe Thr Ile Ala Trp Asp Trp Asp Arg Gly Ala Glu Ala Ile Lys Ala 
225                 230                 235                 240 


Trp Gln Glu Trp Leu Ala Thr Ala Asp Gly Arg Ile Asn Thr Leu Phe 
                245                 250                 255     


Ile Ala Tyr Pro Gln Asp Gln Asp Met Phe Ala Ala Leu Gly Cys Phe 
            260                 265                 270         


Glu Gly Asp Ala Ala Glu Leu Glu Pro Leu Ile Ala Pro Leu Val His 
        275                 280                 285             


Ala Val Glu Pro Thr Glu Lys Val Ala Glu Thr Met Pro Trp Ile Glu 
    290                 295                 300                 


Ala Leu Ser Phe Val Glu Thr Met Gln Gly Glu Ala Met Lys Ala Thr 
305                 310                 315                 320 


Ser Val Arg Ala Lys Gly Asn Leu Ser Phe Val Thr Glu Pro Leu Gly 
                325                 330                 335     


Asp Arg Ala Val Glu Glu Ile Lys Lys Ala Leu Ala Gln Ala Pro Ser 
            340                 345                 350         


His Arg Ala Glu Val Val Leu Tyr Gly Leu Gly Gly Ala Val Ala Ala 
        355                 360                 365             


Lys Gly Arg Arg Glu Thr Ala Phe Val His Arg Asp Ala Pro Val Ala 
    370                 375                 380                 


Leu Asn Tyr His Thr Asp Trp Asp Asp Glu Ala Glu Asp Asp Leu Asn 
385                 390                 395                 400 


Phe Ala Trp Ile Gln Asn Leu Arg Ala Ser Val Ala Ala His Thr Glu 
                405                 410                 415     


Gly Arg Gly Ser Tyr Val Asn Thr Ile Asp Leu Thr Val Glu His Trp 
            420                 425                 430         


Leu Trp Asp Tyr Tyr Glu Glu Asn Leu Pro Arg Leu Met Ala Val Lys 
        435                 440                 445             


Lys Arg Tyr Asp Pro Glu Asp Val Phe Arg His Pro Gln Ser Ile Pro 
    450                 455                 460                 


Val Ser Leu Thr Glu Ala Glu Ala Ala Glu Leu Gly Ile Pro Pro His 
465                 470                 475                 480 


Ile Ala Glu Glu Leu Arg Ala Ala Arg Gln Leu Arg 
                485                 490         


<210> 20
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Thr Ser Gly Thr Lys Gly Lys Arg Pro Phe Thr Gly Arg Val Ile Gly 
1               5                   10                  15      


Pro Ala Asp Gly Glu Phe Asp Glu Ala Arg Arg Val Trp Asn Glu Cys 
            20                  25                  30          


Phe Ala Ala Arg Pro Lys Glu Ile Val Tyr Cys Ala Asp Thr Arg Asp 
        35                  40                  45              


Val Val Arg Ala Leu Arg Glu Val Arg Gln Arg Gly Gly Pro Phe Arg 
    50                  55                  60                  


Val Arg Ser Gly Gly His Ser Met Ser Gly Leu Ser Val Leu Asp Asp 
65                  70                  75                  80  


Gly Thr Val Leu Asp Val Ser Gly Leu Asp Asp Ile Gln Val Ser Glu 
                85                  90                  95      


Asp Ala Ser Thr Val Thr Val Gly Ser Gly Ala His Leu Gly Asp Ile 
            100                 105                 110         


Phe Arg Ala Leu Trp Ala Arg Gly Val Thr Val Pro Ala Gly Phe Cys 
        115                 120                 125             


Pro Glu Ile Gly Ile Ala Gly His Val Leu Gly Gly Gly Ala Gly Ile 
    130                 135                 140                 


Leu Val Arg Ser Arg Gly Phe Leu Ser Asp His Leu Val Ala Leu Glu 
145                 150                 155                 160 


Met Val Asp Ser Glu Gly Arg Ile Val Val Ala Asp His Asp Ser His 
                165                 170                 175     


His Glu Leu Leu Trp Ala Ser Arg Gly Gly Gly Gly Gly Asn Phe Gly 
            180                 185                 190         


Ile Ala Thr Ser Phe Thr Leu Arg Thr Gln Pro Ile Gly Asp Val Thr 
        195                 200                 205             


Leu Phe Thr Ile Ala Trp Asp Trp Asp Arg Gly Ala Glu Ala Ile Lys 
    210                 215                 220                 


Ala Trp Gln Glu Trp Leu Ala Thr Ala Asp Gly Arg Ile Asn Thr Leu 
225                 230                 235                 240 


Phe Ile Ala Tyr Pro Gln Asp Gln Asp Met Phe Ala Ala Leu Gly Cys 
                245                 250                 255     


Phe Glu Gly Asp Ala Ala Glu Leu Glu Pro Leu Ile Ala Pro Leu Val 
            260                 265                 270         


His Ala Val Glu Pro Thr Glu Lys Val Ala Glu Thr Met Pro Trp Ile 
        275                 280                 285             


Glu Ala Leu Ser Phe Val Glu Thr Met Gln Gly Glu Ala Met Lys Ala 
    290                 295                 300                 


Thr Ser Val Arg Ala Lys Gly Asn Leu Ser Phe Val Thr Glu Pro Leu 
305                 310                 315                 320 


Gly Asp Arg Ala Val Glu Glu Ile Lys Lys Ala Leu Ala Gln Ala Pro 
                325                 330                 335     


Ser His Arg Ala Glu Val Val Leu Tyr Gly Leu Gly Gly Ala Val Ala 
            340                 345                 350         


Ala Lys Gly Arg Arg Glu Thr Ala Phe Val His Arg Asp Ala Pro Val 
        355                 360                 365             


Ala Leu Asn Tyr His Thr Asp Trp Asp Asp Glu Ala Glu Asp Asp Leu 
    370                 375                 380                 


Asn Phe Ala Trp Ile Gln Asn Leu Arg Ala Ser Val Ala Ala His Thr 
385                 390                 395                 400 


Glu Gly Arg Gly Ser Tyr Val Asn Thr Ile Asp Leu Thr Val Glu His 
                405                 410                 415     


Trp Leu Trp Asp Tyr Tyr Glu Glu Asn Leu Pro Arg Leu Met Ala Val 
            420                 425                 430         


Lys Lys Arg Tyr Asp Pro Glu Asp Val Phe Arg His Pro Gln Ser Ile 
        435                 440                 445             


Pro Val Ser Leu Thr Glu Ala Glu Ala Ala Glu Leu Gly Ile Pro Pro 
    450                 455                 460                 


His Ile Ala Glu Glu Leu Arg Ala Ala Arg Gln Leu Arg 
465                 470                 475         


<210> 21
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 21
His His His His His His 
1               5       


<210> 22
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Lys His His His His His His His His Gly Gly Leu Val Pro Arg 
1               5                   10                  15      


Gly Ser His Gly Met Thr Ala Asp Pro Ser Ser Glu Arg Ser Asp Met 
            20                  25                  30          


Asn Glu Ala Asp Glu Val Asn Glu Val Asp Glu Leu Ser Glu Thr Gly 
        35                  40                  45              


Gln Thr Ser Gly Thr Lys Gly Lys Arg Pro Phe Thr 
    50                  55                  60  


<210> 23
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Ser His Gly Thr Ala Asp Pro Ser Ser Glu Arg Ser Asp Met Asn Glu 
1               5                   10                  15      


Ala Asp Glu Val Asn Glu Val Asp Glu Leu Ser Glu Thr Gly Gln Thr 
            20                  25                  30          


Ser Gly Thr Lys Gly Lys Arg Pro Phe Thr 
        35                  40          


<210> 24
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Ser His Gly Ala Asp Glu Val Asn Glu Val Asp Glu Leu Ser Glu Thr 
1               5                   10                  15      


Gly Gln Thr Ser Gly Thr Lys Gly Lys Arg Pro Phe Thr 
            20                  25                  


<210> 25
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Ser His Gly Thr Ser Gly Thr Lys Gly Lys Arg Pro Phe Thr 
1               5                   10                  


