
                         SEQUENCE LISTING

<110>  SOLSTAR PHARMA INC.
 
<120>  ANTIVIRAL SILENCING RNA MOLECULES, CHEMICALLY MODIFIED ANTIVIRAL 
       SILENCING RNA MOLECULES WITH ENHANCED CELL PENETRATING ABILITIES,
        PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND USES THEREOF FOR
        TREATMENT OF VIRAL INFECTIONS

<130>  316398.21

<150>  US 63/074,619
<151>  2020-09-04

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<400>  1
aauuauuaac cacauaagcc a                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<400>  2
gcuuaugugg uuaauaauua a                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<400>  3
uaauucuaag cauguuaggc a                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<400>  4
ccuaacaugc uuagaauuau g                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<400>  5
ucauaaacgg auuauagacg u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<400>  6
gucuauaauc cguuuaugau u                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  Phosphorothioate bond

<400>  7
aauuauuaac cacauaagcc a                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Phosphorothioate bond

<400>  8
gcuuaugugg uuaauaauut t                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  Phosphorothioate bond

<400>  9
uaauucuaag cauguuaggc a                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Phosphorothioate bond

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Phosphorothioate bond

<400>  10
ccuaacaugc uuagaauuat t                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  Phosphorothioate bond

<400>  11
ucauaaacgg auuauagacg u                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Phosphorothioate bond

<400>  12
gucuauaauc cguuuaugat t                                                 21


<210>  13
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  Phosphorothioate bond

<400>  13
aauuauuaac cacauaagcc a                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  4'-aminoethyl-2'-fluorouridine

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Phosphorothioate bond

<400>  14
gcuuaugugg uuaauaauut t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  Phosphorothioate bond

<400>  15
uaauucuaag cauguuaggc a                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  4'-aminoethyl-2'-fluorouridine

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Phosphorothioate bond

<400>  16
ccuaacaugc uuagaauuat t                                                 21


<210>  17
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  Phosphorothioate bond

<400>  17
ucauaaacgg auuauagacg u                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  4'-aminoethyl-2'-fluorouridine

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Phosphorothioate bond

<400>  18
gucuauaauc cguuuaugat t                                                 21


<210>  19
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-Fluoronucleoside

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  Phosphorothioate bond

<400>  19
ucauaaacgg auuauagacg u                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial construct


<220>
<221>  misc_RNA
<222>  (1)..(21)
<223>  siRNA

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Methylnucleoside

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5'-aminopropyl-2'-OMe-uridine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5'-aminopropyl-2'-OMe-uridine

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Phosphorothioate bond

<400>  20
gucuauaauc cguuuaugat t                                                 21


