                               SEQUENCE LISTING

<110> GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
 
<120> MEDICAL USE

<130> PU66973

<140>
<141>

<150> 63/074,425
<151> 2020-09-03

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1
gaccccaaaa tcagcgaaat                                                   20


<210> 2
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 2
tctggttact gccagttgaa tctg                                              24


<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 3
accccgcatt acgtttggtg gacc                                              24


<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 4
ttacaaacat tggccgcaaa                                                   20


<210> 5
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 5
gcgcgacatt ccgaagaa                                                     18


<210> 6
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 6
acaatttgcc cccagcgctt cag                                               23


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Val Ala Arg Leu Gln Ser Gly Phe Gly 
1               5                   


<210> 8
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Lys Thr Ser Ala Val Leu Gln Ser Gly Phe Arg Lys Met Glu 
1               5                   10                  


<210> 9
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Glu Ser Ala Thr Leu Gln Ser Gly Leu Arg Lys Ala Lys 
1               5                   10              


<210> 10
<211> 1548
<212> DNA
<213> Homo sapiens

<400> 10
atgcttttga gccagaatgc cttcatcttc agatcactta atttggttct catggtgtat       60

atcagcctcg tgtttggtat ttcatatgat tcgcctgatt acacagatga atcttgcact      120

ttcaagatat cattgcgaaa tttccggtcc atcttatcat gggaattaaa aaaccactcc      180

attgtaccaa ctcactatac attgctgtat acaatcatga gtaaaccaga agatttgaag      240

gtggttaaga actgtgcaaa taccacaaga tcattttgtg acctcacaga tgagtggaga      300

agcacacacg aggcctatgt caccgtccta gaaggattca gcgggaacac aacgttgttc      360

agttgctcac acaatttctg gctggccata gacatgtctt ttgaaccacc agagtttgag      420

attgttggtt ttaccaacca cattaatgtg atggtgaaat ttccatctat tgttgaggaa      480

gaattacagt ttgatttatc tctcgtcatt gaagaacagt cagagggaat tgttaagaag      540

cataaacccg aaataaaagg aaacatgagt ggaaatttca cctatatcat tgacaagtta      600

attccaaaca cgaactactg tgtatctgtt tatttagagc acagtgatga gcaagcagta      660

ataaagtctc ccttaaaatg caccctcctt ccacctggcc aggaatcaga atcagcagaa      720

tctgccaaaa taggaggaat aattactgtg tttttgatag cattggtctt gacaagcacc      780

atagtgacac tgaaatggat tggttatata tgcttaagaa atagcctccc caaagtcttg      840

aattttcata actttttagc ctggccattt cctaacctgc caccgttgga agccatggat      900

atggtggagg tcatttacat caacagaaag aagaaagtgt gggattataa ttatgatgat      960

gaaagtgata gcgatactga ggcagcgccc aggacaagtg gcggtggcta taccatgcat     1020

ggactgactg tcaggcctct gggtcaggcc tctgccacct ctacagaatc ccagttgata     1080

gacccggagt ccgaggagga gcctgacctg cctgaggttg atgtggagct ccccacgatg     1140

ccaaaggaca gccctcagca gttggaactc ttgagtgggc cctgtgagag gagaaagagt     1200

ccactccagg acccttttcc cgaagaggac tacagctcca cggaggggtc tgggggcaga     1260

attaccttca atgtggactt aaactctgtg tttttgagag ttcttgatga cgaggacagt     1320

gacgacttag aagcccctct gatgctatcg tctcatctgg aagagatggt tgacccagag     1380

gatcctgata atgtgcaatc aaaccatttg ctggccagcg gggaagggac acagccaacc     1440

tttcccagcc cctcttcaga gggcctgtgg tccgaagatg ctccatctga tcaaagtgac     1500

acttctgagt cagatgttga ccttggggat ggttatataa tgagatga                  1548


<210> 11
<211> 515
<212> PRT
<213> Homo sapiens

<400> 11
Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val 
1               5                   10                  15      


Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro 
            20                  25                  30          


Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe 
        35                  40                  45              


Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr 
    50                  55                  60                  


His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys 
65                  70                  75                  80  


Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr 
                85                  90                  95      


Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly 
            100                 105                 110         


Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu 
        115                 120                 125             


Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe 
    130                 135                 140                 


Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu 
145                 150                 155                 160 


Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly 
                165                 170                 175     


Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn 
            180                 185                 190         


Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val 
        195                 200                 205             


Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro 
    210                 215                 220                 


Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu 
225                 230                 235                 240 


Ser Ala Lys Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val 
                245                 250                 255     


Leu Thr Ser Thr Ile Val Thr Leu Lys Trp Ile Gly Tyr Ile Cys Leu 
            260                 265                 270         


Arg Asn Ser Leu Pro Lys Val Leu Asn Phe His Asn Phe Leu Ala Trp 
        275                 280                 285             


Pro Phe Pro Asn Leu Pro Pro Leu Glu Ala Met Asp Met Val Glu Val 
    290                 295                 300                 


Ile Tyr Ile Asn Arg Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp 
305                 310                 315                 320 


Glu Ser Asp Ser Asp Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly 
                325                 330                 335     


Tyr Thr Met His Gly Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala 
            340                 345                 350         


Thr Ser Thr Glu Ser Gln Leu Ile Asp Pro Glu Ser Glu Glu Glu Pro 
        355                 360                 365             


Asp Leu Pro Glu Val Asp Val Glu Leu Pro Thr Met Pro Lys Asp Ser 
    370                 375                 380                 


Pro Gln Gln Leu Glu Leu Leu Ser Gly Pro Cys Glu Arg Arg Lys Ser 
385                 390                 395                 400 


Pro Leu Gln Asp Pro Phe Pro Glu Glu Asp Tyr Ser Ser Thr Glu Gly 
                405                 410                 415     


Ser Gly Gly Arg Ile Thr Phe Asn Val Asp Leu Asn Ser Val Phe Leu 
            420                 425                 430         


Arg Val Leu Asp Asp Glu Asp Ser Asp Asp Leu Glu Ala Pro Leu Met 
        435                 440                 445             


Leu Ser Ser His Leu Glu Glu Met Val Asp Pro Glu Asp Pro Asp Asn 
    450                 455                 460                 


Val Gln Ser Asn His Leu Leu Ala Ser Gly Glu Gly Thr Gln Pro Thr 
465                 470                 475                 480 


Phe Pro Ser Pro Ser Ser Glu Gly Leu Trp Ser Glu Asp Ala Pro Ser 
                485                 490                 495     


Asp Gln Ser Asp Thr Ser Glu Ser Asp Val Asp Leu Gly Asp Gly Tyr 
            500                 505                 510         


Ile Met Arg 
        515 


<210> 12
<211> 1548
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
atgcttttga gccagaatgc cttcatcttc agatcactta atttggttct catggtgtat       60

atcagcctcg tgtttggtat ttcatatgat tcgcctgatt acacagatga atcttgcact      120

ttcaagatat cattgcgaaa tttccggtcc atcttatcat gggaattaaa aaaccactcc      180

attgtaccaa ctcactatac attgctgtat acaatcatga gtaaaccaga agatttgaag      240

gtggttaaga actgtgcaaa taccacaaga tcattttgtg acctcacaga tgagtggaga      300

agcacacacg aggcctatgt caccgtccta gaaggattca gcgggaacac aacgttgttc      360

agttgctcac acaatttctg gctggccata gacatgtctt ttgaaccacc agagtttgag      420

attgttggtt ttaccaacca cattaatgtg atggtgaaat ttccatctat tgttgaggaa      480

gaattacagt ttgatttatc tctcgtcatt gaagaacagt cagagggaat tgttaagaag      540

cataaacccg aaataaaagg aaacatgagt ggaaatttca cctatatcat tgacaagtta      600

attccaaaca cgaactactg tgtatctgtt tatttagagc acagtgatga gcaagcagta      660

ataaagtctc ccttaaaatg caccctcctt ccacctggcc aggaatcaga atcagcagaa      720

tctgccaaaa taggaggaat aattactgtg tttttgatag cattggtctt gacaagcacc      780

atagtgacac tgaaatggat tggttatata tgcttaagaa atagcctccc caaagtcttg      840

aattttcata actttttagc ctggccattt cctaacctgc caccgttgga agccatggat      900

atggtggagg tcatttacat caacagaaag aagaaagtgt gggattataa ttatgatgat      960

gaaagtgata gcgatactga ggcagcgccc aggacaagtg gcggtggcta taccatgcat     1020

ggactgactg tcaggcctct gggtcaggcc tctgccacct ctacagaatc ccagttgata     1080

gacccggagt ccgaggagga gcctgacctg cctgaggttg atgtggagct ccccacgatg     1140

ccaaaggaca gccctcagca gttggaactc ttgagtgggc cctgtgagag gagaaagagt     1200

ccactccagg acccttttcc cgaagaggac tacagctcca cggaggggtc tgggggcaga     1260

attaccttca atgtggactt aaactctgtg tttttgagag ttcttgatga cgaggacagt     1320

gacgacttag aagcccctct gatgctatcg tctcatctgg aagagatggt tgacccagag     1380

gatcctgata atgtgcaatc aaaccatttg ctggccagcg gggaagggac acagccaacc     1440

tttcccagcc cctcttcaga gggcctgtgg tccgaagatg ctccatctga tcaaagtgac     1500

acttctgagt cagatgttga ccttggggat ggttatataa tgagatga                  1548


<210> 13
<211> 515
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val 
1               5                   10                  15      


Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro 
            20                  25                  30          


Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe 
        35                  40                  45              


Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr 
    50                  55                  60                  


His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys 
65                  70                  75                  80  


Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr 
                85                  90                  95      


Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly 
            100                 105                 110         


Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu 
        115                 120                 125             


Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe 
    130                 135                 140                 


Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu 
145                 150                 155                 160 


Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly 
                165                 170                 175     


Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn 
            180                 185                 190         


Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val 
        195                 200                 205             


Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro 
    210                 215                 220                 


Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu 
225                 230                 235                 240 


Ser Ala Lys Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val 
                245                 250                 255     


Leu Thr Ser Thr Ile Val Thr Leu Lys Trp Ile Gly Tyr Ile Cys Leu 
            260                 265                 270         


Arg Asn Ser Leu Pro Lys Val Leu Asn Phe His Asn Phe Leu Ala Trp 
        275                 280                 285             


Pro Phe Pro Asn Leu Pro Pro Leu Glu Ala Met Asp Met Val Glu Val 
    290                 295                 300                 


Ile Tyr Ile Asn Arg Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp 
305                 310                 315                 320 


Glu Ser Asp Ser Asp Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly 
                325                 330                 335     


Tyr Thr Met His Gly Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala 
            340                 345                 350         


Thr Ser Thr Glu Ser Gln Leu Ile Asp Pro Glu Ser Glu Glu Glu Pro 
        355                 360                 365             


Asp Leu Pro Glu Val Asp Val Glu Leu Pro Thr Met Pro Lys Asp Ser 
    370                 375                 380                 


Pro Gln Gln Leu Glu Leu Leu Ser Gly Pro Cys Glu Arg Arg Lys Ser 
385                 390                 395                 400 


Pro Leu Gln Asp Pro Phe Pro Glu Glu Asp Tyr Ser Ser Thr Glu Gly 
                405                 410                 415     


Ser Gly Gly Arg Ile Thr Phe Asn Val Asp Leu Asn Ser Val Phe Leu 
            420                 425                 430         


Arg Val Leu Asp Asp Glu Asp Ser Asp Asp Leu Glu Ala Pro Leu Met 
        435                 440                 445             


Leu Ser Ser His Leu Glu Glu Met Val Asp Pro Glu Asp Pro Asp Asn 
    450                 455                 460                 


Val Gln Ser Asn His Leu Leu Ala Ser Gly Glu Gly Thr Gln Pro Thr 
465                 470                 475                 480 


Phe Pro Ser Pro Ser Ser Glu Gly Leu Trp Ser Glu Asp Ala Pro Ser 
                485                 490                 495     


Asp Gln Ser Asp Thr Ser Glu Ser Asp Val Asp Leu Gly Asp Gly Tyr 
            500                 505                 510         


Ile Met Arg 
        515 


