                         SEQUENCE LISTING

<110>  Curebiotec GmbH
 
<120>  Method for the treatment of a disease using pigment 
       epithelium-derived factor (PEDF)

<130>  S 10126 PCT

<150>  EP 20 194 463.4
<151>  2020-09-03

<150>  EP 20 195 140.7
<151>  2020-09-08

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp Pro Asp Ser 
1               5                   10                  15      


Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys Val Pro Val 
            20                  25                  30          


Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp Leu Tyr Arg 
        35                  40                  45              


Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu Ser Pro Leu 
    50                  55                  60                  


Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala Glu Gln Arg 
65                  70                  75                  80  


Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu Ile Ser Ser 
                85                  90                  95      


Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr Val Thr Ala 
            100                 105                 110         


Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe Glu Lys Lys 
        115                 120                 125             


Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys Ser Tyr Gly 
    130                 135                 140                 


Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp Leu Gln Glu 
145                 150                 155                 160 


Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu Ala Arg Ser 
                165                 170                 175     


Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu Gly Val Ala 
            180                 185                 190         


His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg Lys Thr Ser 
        195                 200                 205             


Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg Val Pro Met 
    210                 215                 220                 


Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp Ser Asp Leu 
225                 230                 235                 240 


Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met Ser Ile Ile 
                245                 250                 255     


Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu Ile Glu Glu 
            260                 265                 270         


Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu Leu Lys Thr 
        275                 280                 285             


Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser Tyr Glu Gly 
    290                 295                 300                 


Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser Leu Phe Asp 
305                 310                 315                 320 


Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys Leu Thr Gln 
                325                 330                 335     


Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly Ala Gly Thr 
            340                 345                 350         


Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe Pro Leu Asp 
        355                 360                 365             


Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp Thr Asp Thr 
    370                 375                 380                 


Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg Gly Pro 
385                 390                 395                 


<210>  2
<211>  1257
<212>  RNA
<213>  Homo sapiens

<400>  2
augcaggccc uggugcuacu ccucugcauu ggagcccucc ucgggcacag cagcugccag       60

aacccugcca gccccccgga ggagggcucc ccagaccccg acagcacagg ggcgcuggug      120

gaggaggagg auccuuucuu caaagucccc gugaacaagc uggcagcggc ugucuccaac      180

uucggcuaug accuguaccg ggugcgaucc agcacgagcc ccacgaccaa cgugcuccug      240

ucuccucuca guguggccac ggcccucucg gcccucucgc ugggagcgga gcagcgaaca      300

gaauccauca uucaccgggc ucucuacuau gacuugauca gcagcccaga cauccauggu      360

accuauaagg agcuccuuga cacggucacc gccccccaga agaaccucaa gagugccucc      420

cggaucgucu uugagaagaa gcugcgcaua aaauccagcu uuguggcacc ucuggaaaag      480

ucauauggga ccaggcccag aguccugacg ggcaacccuc gcuuggaccu gcaagagauc      540

aacaacuggg ugcaggcgca gaugaaaggg aagcucgcca gguccacaaa ggaaauuccc      600

gaugagauca gcauucuccu ucucggugug gcgcacuuca aggggcagug gguaacaaag      660

uuugacucca gaaagacuuc ccucgaggau uucuacuugg augaagagag gaccgugagg      720

guccccauga ugucggaccc uaaggcuguu uuacgcuaug gcuuggauuc agaucucagc      780

ugcaagauug cccagcugcc cuugaccgga agcaugagua ucaucuucuu ccugccccug      840

aaagugaccc agaauuugac cuugauagag gagagccuca ccuccgaguu cauucaugac      900

auagaccgag aacugaagac cgugcaggcg guccucacug uccccaagcu gaagcugagu      960

uacgaaggcg aagucaccaa gucccugcag gagaugaagc ugcaauccuu guuugauuca     1020

ccagacuuua gcaagaucac aggcaaaccc aucaagcuga cucaggugga acaccgggcu     1080

ggcuuugagu ggaacgagga uggggcggga accaccccca gcccagggcu gcagccugcc     1140

caccucaccu ucccgcugga cuaucaccuu aaccagccuu ucaucuucgu acugagggac     1200

acagacacag gggcccuucu cuucauuggc aagauucugg accccagggg ccccuaa        1257


<210>  3
<211>  1000
<212>  RNA
<213>  Homo sapiens

<400>  3
ggacgcugga uuagaaggca gcaaaaaaag aucugugcug gcuggagccc ccucagugug       60

caggcuuaga gggacuaggc ugggugugga gcugcagcgu auccacaggc cccaggaugc      120

aggcccuggu gcuacuccuc ugcauuggag cccuccucgg gcacagcagc ugccagaacc      180

cugccagccc cccggaggag ggcuccccag accccgacag cacaggggcg cugguggagg      240

aggaggaucc uuucuucaaa guccccguga acaagcuggc agcggcuguc uccaacuucg      300

gcuaugaccu guaccgggug cgauccagca ugagccccac gaccaacgug cuccugucuc      360

cucucagugu ggccacggcc cucucggccc ucucgcuggg agcggacgag cgaacagaau      420

ccaucauuca ccgggcucuc uacuaugacu ugaucagcag cccagacauc caugguaccu      480

auaaggagcu ccuugacacg gucacugccc cccagaagaa ccucaagagu gccucccgga      540

ucgucuuuga gaagaagcur cgcauaaaau ccagcuuugu ggcaccucug gaaaagucau      600

augggaccag gcccagaguc cugacgggca acccucgcuu ggaccugcaa gagaucaaca      660

acugggugca ggcgcagaug aaagggaagc ucgccagguc cacaaaggaa auucccgaug      720

agaucagcau ucuccuucuc gguguggcgc acuucaaggg gcagugggua acaaaguuug      780

acuccagaaa gacuucccuc gaggauuucu acuuggauga agagaggacc gugagggucc      840

ccaugauguc ggacccuaag gcuguuuuac gcuauggcuu ggauucagau cucagcugca      900

agauugccca gcugcccuug accggaagca ugaguaucau cuucuuccug ccccugaaag      960

ugacccagaa uuugaccuug auagaggaga gccucaccuc                           1000


<210>  4
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 
            340                 345                 350         


Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 
        355                 360                 365             


Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 
    370                 375                 380                 


Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 
385                 390                 395                 400 


Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
                405                 410         


<210>  5
<211>  3660
<212>  RNA
<213>  Homo sapiens

<400>  5
gcggaggcuu ggggcagccg gguagcucgg aggucguggc gcugggggcu agcaccagcg       60

cucugucggg aggcgcagcg guuaggugga ccggucagcg gacucaccgg ccagggcgcu      120

cggugcugga auuugauauu cauugauccg gguuuuaucc cucuucuuuu uucuuaaaca      180

uuuuuuuuua aaacuguauu guuucucguu uuaauuuauu uuugcuugcc auuccccacu      240

ugaaucgggc cgacggcuug gggagauugc ucuacuuccc caaaucacug uggauuuugg      300

aaaccagcag aaagaggaaa gagguagcaa gagcuccaga gagaagucga ggaagagaga      360

gacgggguca gagagagcgc gcgggcgugc gagcagcgaa agcgacaggg gcaaagugag      420

ugaccugcuu uuggggguga ccgccggagc gcggcgugag cccucccccu ugggaucccg      480

cagcugacca gucgcgcuga cggacagaca gacagacacc gcccccagcc ccagcuacca      540

ccuccucccc ggccggcggc ggacagugga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg uggagggggu cggggcucgc ggcgucgcac ugaaacuuuu      660

cguccaacuu cugggcuguu cucgcuucgg aggagccgug guccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gugcuagcuc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag uggcgacucg gcgcucggaa      840

gccgggcuca uggacgggug aggcggcggu gugcgcagac agugcuccag ccgcgcgcgc      900

uccccaggcc cuggcccggg ccucgggccg gggaggaaga guagcucgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

ucgggccucc gaaaccauga acuuucugcu gucuugggug cauuggagcc uugccuugcu     1080

gcucuaccuc caccaugcca agugguccca ggcugcaccc auggcagaag gaggagggca     1140

gaaucaucac gaagugguga aguucaugga ugucuaucag cgcagcuacu gccauccaau     1200

cgagacccug guggacaucu uccaggagua cccugaugag aucgaguaca ucuucaagcc     1260

auccugugug ccccugaugc gaugcggggg cugcugcaau gacgagggcc uggagugugu     1320

gcccacugag gaguccaaca ucaccaugca gauuaugcgg aucaaaccuc accaaggcca     1380

gcacauagga gagaugagcu uccuacagca caacaaaugu gaaugcagac caaagaaaga     1440

uagagcaaga caagaaaaaa aaucaguucg aggaaaggga aaggggcaaa aacgaaagcg     1500

caagaaaucc cgguauaagu ccuggagcgu guacguuggu gcccgcugcu gucuaaugcc     1560

cuggagccuc ccuggccccc aucccugugg gccuugcuca gagcggagaa agcauuuguu     1620

uguacaagau ccgcagacgu guaaauguuc cugcaaaaac acagacucgc guugcaaggc     1680

gaggcagcuu gaguuaaacg aacguacuug cagaugugac aagccgaggc ggugagccgg     1740

gcaggaggaa ggagccuccc ucaggguuuc gggaaccaga ucucucacca ggaaagacug     1800

auacagaacg aucgauacag aaaccacgcu gccgccacca caccaucacc aucgacagaa     1860

caguccuuaa uccagaaacc ugaaaugaag gaagaggaga cucugcgcag agcacuuugg     1920

guccggaggg cgagacuccg gcggaagcau ucccgggcgg gugacccagc acggucccuc     1980

uuggaauugg auucgccauu uuauuuuucu ugcugcuaaa ucaccgagcc cggaagauua     2040

gagaguuuua uuucugggau uccuguagac acacccaccc acauacauac auuuauauau     2100

auauauauua uauauauaua aaaauaaaua ucucuauuuu auauauauaa aauauauaua     2160

uucuuuuuuu aaauuaacag ugcuaauguu auuggugucu ucacuggaug uauuugacug     2220

cuguggacuu gaguugggag gggaauguuc ccacucagau ccugacaggg aagaggagga     2280

gaugagagac ucuggcauga ucuuuuuuuu gucccacuug guggggccag gguccucucc     2340

ccugcccagg aaugugcaag gccagggcau gggggcaaau augacccagu uuugggaaca     2400

ccgacaaacc cagcccuggc gcugagccuc ucuaccccag gucagacgga cagaaagaca     2460

gaucacaggu acagggauga ggacaccggc ucugaccagg aguuugggga gcuucaggac     2520

auugcugugc uuuggggauu cccuccacau gcugcacgcg caucucgccc ccaggggcac     2580

ugccuggaag auucaggagc cugggcggcc uucgcuuacu cucaccugcu ucugaguugc     2640

ccaggagacc acuggcagau gucccggcga agagaagaga cacauuguug gaagaagcag     2700

cccaugacag cuccccuucc ugggacucgc ccucauccuc uuccugcucc ccuuccuggg     2760

gugcagccua aaaggaccua uguccucaca ccauugaaac cacuaguucu guccccccag     2820

gagaccuggu ugugugugug ugagugguug accuuccucc auccccuggu ccuucccuuc     2880

ccuucccgag gcacagagag acagggcagg auccacgugc ccauugugga ggcagagaaa     2940

agagaaagug uuuuauauac gguacuuauu uaauaucccu uuuuaauuag aaauuaaaac     3000

aguuaauuua auuaaagagu aggguuuuuu uucaguauuc uugguuaaua uuuaauuuca     3060

acuauuuaug agauguaucu uuugcucucu cuugcucucu uauuuguacc gguuuuugua     3120

uauaaaauuc auguuuccaa ucucucucuc ccugaucggu gacagucacu agcuuaucuu     3180

gaacagauau uuaauuuugc uaacacucag cucugcccuc cccgaucccc uggcucccca     3240

gcacacauuc cuuugaaaua agguuucaau auacaucuac auacuauaua uauauuuggc     3300

aacuuguauu uguguguaua uauauauaua uauguuuaug uauauaugug auucugauaa     3360

aauagacauu gcuauucugu uuuuuauaug uaaaaacaaa acaagaaaaa auagagaauu     3420

cuacauacua aaucucucuc cuuuuuuaau uuuaauauuu guuaucauuu auuuauuggu     3480

gcuacuguuu auccguaaua auugugggga aaagauauua acaucacguc uuugucucua     3540

gugcaguuuu ucgagauauu ccguaguaca uauuuauuuu uaaacaacga caaagaaaua     3600

cagauauauc uuaaaaaaaa aaaagcauuu uguauuaaag aauuuaauuc ugaucucaaa     3660


<210>  6
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Pro Cys Gly Pro Cys Ser Glu 
            340                 345                 350         


Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser 
        355                 360                 365             


Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn 
    370                 375                 380                 


Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
385                 390                 395 


<210>  7
<211>  3609
<212>  RNA
<213>  Homo sapiens

<400>  7
gcggaggcuu ggggcagccg gguagcucgg aggucguggc gcugggggcu agcaccagcg       60

cucugucggg aggcgcagcg guuaggugga ccggucagcg gacucaccgg ccagggcgcu      120

cggugcugga auuugauauu cauugauccg gguuuuaucc cucuucuuuu uucuuaaaca      180

uuuuuuuuua aaacuguauu guuucucguu uuaauuuauu uuugcuugcc auuccccacu      240

ugaaucgggc cgacggcuug gggagauugc ucuacuuccc caaaucacug uggauuuugg      300

aaaccagcag aaagaggaaa gagguagcaa gagcuccaga gagaagucga ggaagagaga      360

gacgggguca gagagagcgc gcgggcgugc gagcagcgaa agcgacaggg gcaaagugag      420

ugaccugcuu uuggggguga ccgccggagc gcggcgugag cccucccccu ugggaucccg      480

cagcugacca gucgcgcuga cggacagaca gacagacacc gcccccagcc ccagcuacca      540

ccuccucccc ggccggcggc ggacagugga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg uggagggggu cggggcucgc ggcgucgcac ugaaacuuuu      660

cguccaacuu cugggcuguu cucgcuucgg aggagccgug guccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gugcuagcuc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag uggcgacucg gcgcucggaa      840

gccgggcuca uggacgggug aggcggcggu gugcgcagac agugcuccag ccgcgcgcgc      900

uccccaggcc cuggcccggg ccucgggccg gggaggaaga guagcucgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

ucgggccucc gaaaccauga acuuucugcu gucuugggug cauuggagcc uugccuugcu     1080

gcucuaccuc caccaugcca agugguccca ggcugcaccc auggcagaag gaggagggca     1140

gaaucaucac gaagugguga aguucaugga ugucuaucag cgcagcuacu gccauccaau     1200

cgagacccug guggacaucu uccaggagua cccugaugag aucgaguaca ucuucaagcc     1260

auccugugug ccccugaugc gaugcggggg cugcugcaau gacgagggcc uggagugugu     1320

gcccacugag gaguccaaca ucaccaugca gauuaugcgg aucaaaccuc accaaggcca     1380

gcacauagga gagaugagcu uccuacagca caacaaaugu gaaugcagac caaagaaaga     1440

uagagcaaga caagaaaaaa aaucaguucg aggaaaggga aaggggcaaa aacgaaagcg     1500

caagaaaucc cgguauaagu ccuggagcgu ucccuguggg ccuugcucag agcggagaaa     1560

gcauuuguuu guacaagauc cgcagacgug uaaauguucc ugcaaaaaca cagacucgcg     1620

uugcaaggcg aggcagcuug aguuaaacga acguacuugc agaugugaca agccgaggcg     1680

gugagccggg caggaggaag gagccucccu caggguuucg ggaaccagau cucucaccag     1740

gaaagacuga uacagaacga ucgauacaga aaccacgcug ccgccaccac accaucacca     1800

ucgacagaac aguccuuaau ccagaaaccu gaaaugaagg aagaggagac ucugcgcaga     1860

gcacuuuggg uccggagggc gagacuccgg cggaagcauu cccgggcggg ugacccagca     1920

cggucccucu uggaauugga uucgccauuu uauuuuucuu gcugcuaaau caccgagccc     1980

ggaagauuag agaguuuuau uucugggauu ccuguagaca cacccaccca cauacauaca     2040

uuuauauaua uauauauuau auauauauaa aaauaaauau cucuauuuua uauauauaaa     2100

auauauauau ucuuuuuuua aauuaacagu gcuaauguua uuggugucuu cacuggaugu     2160

auuugacugc uguggacuug aguugggagg ggaauguucc cacucagauc cugacaggga     2220

agaggaggag augagagacu cuggcaugau cuuuuuuuug ucccacuugg uggggccagg     2280

guccucuccc cugcccagga augugcaagg ccagggcaug ggggcaaaua ugacccaguu     2340

uugggaacac cgacaaaccc agcccuggcg cugagccucu cuaccccagg ucagacggac     2400

agaaagacag aucacaggua cagggaugag gacaccggcu cugaccagga guuuggggag     2460

cuucaggaca uugcugugcu uuggggauuc ccuccacaug cugcacgcgc aucucgcccc     2520

caggggcacu gccuggaaga uucaggagcc ugggcggccu ucgcuuacuc ucaccugcuu     2580

cugaguugcc caggagacca cuggcagaug ucccggcgaa gagaagagac acauuguugg     2640

aagaagcagc ccaugacagc uccccuuccu gggacucgcc cucauccucu uccugcuccc     2700

cuuccugggg ugcagccuaa aaggaccuau guccucacac cauugaaacc acuaguucug     2760

uccccccagg agaccugguu gugugugugu gagugguuga ccuuccucca uccccugguc     2820

cuucccuucc cuucccgagg cacagagaga cagggcagga uccacgugcc cauuguggag     2880

gcagagaaaa gagaaagugu uuuauauacg guacuuauuu aauaucccuu uuuaauuaga     2940

aauuaaaaca guuaauuuaa uuaaagagua ggguuuuuuu ucaguauucu ugguuaauau     3000

uuaauuucaa cuauuuauga gauguaucuu uugcucucuc uugcucucuu auuuguaccg     3060

guuuuuguau auaaaauuca uguuuccaau cucucucucc cugaucggug acagucacua     3120

gcuuaucuug aacagauauu uaauuuugcu aacacucagc ucugcccucc ccgauccccu     3180

ggcuccccag cacacauucc uuugaaauaa gguuucaaua uacaucuaca uacuauauau     3240

auauuuggca acuuguauuu guguguauau auauauauau auguuuaugu auauauguga     3300

uucugauaaa auagacauug cuauucuguu uuuuauaugu aaaaacaaaa caagaaaaaa     3360

uagagaauuc uacauacuaa aucucucucc uuuuuuaauu uuaauauuug uuaucauuua     3420

uuuauuggug cuacuguuua uccguaauaa uuguggggaa aagauauuaa caucacgucu     3480

uugucucuag ugcaguuuuu cgagauauuc cguaguacau auuuauuuuu aaacaacgac     3540

aaagaaauac agauauaucu uaaaaaaaaa aaagcauuuu guauuaaaga auuuaauucu     3600

gaucucaaa                                                             3609


<210>  8
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
            340                 345                 350         


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
        355                 360                 365             


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
    370                 375                 380                 


Asp Lys Pro Arg Arg 
385                 


<210>  9
<211>  3591
<212>  RNA
<213>  Homo sapiens

<400>  9
gcggaggcuu ggggcagccg gguagcucgg aggucguggc gcugggggcu agcaccagcg       60

cucugucggg aggcgcagcg guuaggugga ccggucagcg gacucaccgg ccagggcgcu      120

cggugcugga auuugauauu cauugauccg gguuuuaucc cucuucuuuu uucuuaaaca      180

uuuuuuuuua aaacuguauu guuucucguu uuaauuuauu uuugcuugcc auuccccacu      240

ugaaucgggc cgacggcuug gggagauugc ucuacuuccc caaaucacug uggauuuugg      300

aaaccagcag aaagaggaaa gagguagcaa gagcuccaga gagaagucga ggaagagaga      360

gacgggguca gagagagcgc gcgggcgugc gagcagcgaa agcgacaggg gcaaagugag      420

ugaccugcuu uuggggguga ccgccggagc gcggcgugag cccucccccu ugggaucccg      480

cagcugacca gucgcgcuga cggacagaca gacagacacc gcccccagcc ccagcuacca      540

ccuccucccc ggccggcggc ggacagugga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg uggagggggu cggggcucgc ggcgucgcac ugaaacuuuu      660

cguccaacuu cugggcuguu cucgcuucgg aggagccgug guccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gugcuagcuc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag uggcgacucg gcgcucggaa      840

gccgggcuca uggacgggug aggcggcggu gugcgcagac agugcuccag ccgcgcgcgc      900

uccccaggcc cuggcccggg ccucgggccg gggaggaaga guagcucgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

ucgggccucc gaaaccauga acuuucugcu gucuugggug cauuggagcc uugccuugcu     1080

gcucuaccuc caccaugcca agugguccca ggcugcaccc auggcagaag gaggagggca     1140

gaaucaucac gaagugguga aguucaugga ugucuaucag cgcagcuacu gccauccaau     1200

cgagacccug guggacaucu uccaggagua cccugaugag aucgaguaca ucuucaagcc     1260

auccugugug ccccugaugc gaugcggggg cugcugcaau gacgagggcc uggagugugu     1320

gcccacugag gaguccaaca ucaccaugca gauuaugcgg aucaaaccuc accaaggcca     1380

gcacauagga gagaugagcu uccuacagca caacaaaugu gaaugcagac caaagaaaga     1440

uagagcaaga caagaaaaaa aaucaguucg aggaaaggga aaggggcaaa aacgaaagcg     1500

caagaaaucc cgucccugug ggccuugcuc agagcggaga aagcauuugu uuguacaaga     1560

uccgcagacg uguaaauguu ccugcaaaaa cacagacucg cguugcaagg cgaggcagcu     1620

ugaguuaaac gaacguacuu gcagauguga caagccgagg cggugagccg ggcaggagga     1680

aggagccucc cucaggguuu cgggaaccag aucucucacc aggaaagacu gauacagaac     1740

gaucgauaca gaaaccacgc ugccgccacc acaccaucac caucgacaga acaguccuua     1800

auccagaaac cugaaaugaa ggaagaggag acucugcgca gagcacuuug gguccggagg     1860

gcgagacucc ggcggaagca uucccgggcg ggugacccag cacggucccu cuuggaauug     1920

gauucgccau uuuauuuuuc uugcugcuaa aucaccgagc ccggaagauu agagaguuuu     1980

auuucuggga uuccuguaga cacacccacc cacauacaua cauuuauaua uauauauauu     2040

auauauauau aaaaauaaau aucucuauuu uauauauaua aaauauauau auucuuuuuu     2100

uaaauuaaca gugcuaaugu uauugguguc uucacuggau guauuugacu gcuguggacu     2160

ugaguuggga ggggaauguu cccacucaga uccugacagg gaagaggagg agaugagaga     2220

cucuggcaug aucuuuuuuu ugucccacuu gguggggcca ggguccucuc cccugcccag     2280

gaaugugcaa ggccagggca ugggggcaaa uaugacccag uuuugggaac accgacaaac     2340

ccagcccugg cgcugagccu cucuacccca ggucagacgg acagaaagac agaucacagg     2400

uacagggaug aggacaccgg cucugaccag gaguuugggg agcuucagga cauugcugug     2460

cuuuggggau ucccuccaca ugcugcacgc gcaucucgcc cccaggggca cugccuggaa     2520

gauucaggag ccugggcggc cuucgcuuac ucucaccugc uucugaguug cccaggagac     2580

cacuggcaga ugucccggcg aagagaagag acacauuguu ggaagaagca gcccaugaca     2640

gcuccccuuc cugggacucg cccucauccu cuuccugcuc cccuuccugg ggugcagccu     2700

aaaaggaccu auguccucac accauugaaa ccacuaguuc ugucccccca ggagaccugg     2760

uugugugugu gugagugguu gaccuuccuc cauccccugg uccuucccuu cccuucccga     2820

ggcacagaga gacagggcag gauccacgug cccauugugg aggcagagaa aagagaaagu     2880

guuuuauaua cgguacuuau uuaauauccc uuuuuaauua gaaauuaaaa caguuaauuu     2940

aauuaaagag uaggguuuuu uuucaguauu cuugguuaau auuuaauuuc aacuauuuau     3000

gagauguauc uuuugcucuc ucuugcucuc uuauuuguac cgguuuuugu auauaaaauu     3060

cauguuucca aucucucucu cccugaucgg ugacagucac uagcuuaucu ugaacagaua     3120

uuuaauuuug cuaacacuca gcucugcccu ccccgauccc cuggcucccc agcacacauu     3180

ccuuugaaau aagguuucaa uauacaucua cauacuauau auauauuugg caacuuguau     3240

uuguguguau auauauauau auauguuuau guauauaugu gauucugaua aaauagacau     3300

ugcuauucug uuuuuuauau guaaaaacaa aacaagaaaa aauagagaau ucuacauacu     3360

aaaucucucu ccuuuuuuaa uuuuaauauu uguuaucauu uauuuauugg ugcuacuguu     3420

uauccguaau aauugugggg aaaagauauu aacaucacgu cuuugucucu agugcaguuu     3480

uucgagauau uccguaguac auauuuauuu uuaaacaacg acaaagaaau acagauauau     3540

cuuaaaaaaa aaaaagcauu uuguauuaaa gaauuuaauu cugaucucaa a              3591


<210>  10
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys 
        355                 360                 365             


Pro Arg Arg 
    370     


<210>  11
<211>  3537
<212>  RNA
<213>  Homo sapiens

<400>  11
gcggaggcuu ggggcagccg gguagcucgg aggucguggc gcugggggcu agcaccagcg       60

cucugucggg aggcgcagcg guuaggugga ccggucagcg gacucaccgg ccagggcgcu      120

cggugcugga auuugauauu cauugauccg gguuuuaucc cucuucuuuu uucuuaaaca      180

uuuuuuuuua aaacuguauu guuucucguu uuaauuuauu uuugcuugcc auuccccacu      240

ugaaucgggc cgacggcuug gggagauugc ucuacuuccc caaaucacug uggauuuugg      300

aaaccagcag aaagaggaaa gagguagcaa gagcuccaga gagaagucga ggaagagaga      360

gacgggguca gagagagcgc gcgggcgugc gagcagcgaa agcgacaggg gcaaagugag      420

ugaccugcuu uuggggguga ccgccggagc gcggcgugag cccucccccu ugggaucccg      480

cagcugacca gucgcgcuga cggacagaca gacagacacc gcccccagcc ccagcuacca      540

ccuccucccc ggccggcggc ggacagugga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg uggagggggu cggggcucgc ggcgucgcac ugaaacuuuu      660

cguccaacuu cugggcuguu cucgcuucgg aggagccgug guccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gugcuagcuc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag uggcgacucg gcgcucggaa      840

gccgggcuca uggacgggug aggcggcggu gugcgcagac agugcuccag ccgcgcgcgc      900

uccccaggcc cuggcccggg ccucgggccg gggaggaaga guagcucgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

ucgggccucc gaaaccauga acuuucugcu gucuugggug cauuggagcc uugccuugcu     1080

gcucuaccuc caccaugcca agugguccca ggcugcaccc auggcagaag gaggagggca     1140

gaaucaucac gaagugguga aguucaugga ugucuaucag cgcagcuacu gccauccaau     1200

cgagacccug guggacaucu uccaggagua cccugaugag aucgaguaca ucuucaagcc     1260

auccugugug ccccugaugc gaugcggggg cugcugcaau gacgagggcc uggagugugu     1320

gcccacugag gaguccaaca ucaccaugca gauuaugcgg aucaaaccuc accaaggcca     1380

gcacauagga gagaugagcu uccuacagca caacaaaugu gaaugcagac caaagaaaga     1440

uagagcaaga caagaaaauc ccugugggcc uugcucagag cggagaaagc auuuguuugu     1500

acaagauccg cagacgugua aauguuccug caaaaacaca gacucgcguu gcaaggcgag     1560

gcagcuugag uuaaacgaac guacuugcag augugacaag ccgaggcggu gagccgggca     1620

ggaggaagga gccucccuca ggguuucggg aaccagaucu cucaccagga aagacugaua     1680

cagaacgauc gauacagaaa ccacgcugcc gccaccacac caucaccauc gacagaacag     1740

uccuuaaucc agaaaccuga aaugaaggaa gaggagacuc ugcgcagagc acuuuggguc     1800

cggagggcga gacuccggcg gaagcauucc cgggcgggug acccagcacg gucccucuug     1860

gaauuggauu cgccauuuua uuuuucuugc ugcuaaauca ccgagcccgg aagauuagag     1920

aguuuuauuu cugggauucc uguagacaca cccacccaca uacauacauu uauauauaua     1980

uauauuauau auauauaaaa auaaauaucu cuauuuuaua uauauaaaau auauauauuc     2040

uuuuuuuaaa uuaacagugc uaauguuauu ggugucuuca cuggauguau uugacugcug     2100

uggacuugag uugggagggg aauguuccca cucagauccu gacagggaag aggaggagau     2160

gagagacucu ggcaugaucu uuuuuuuguc ccacuuggug gggccagggu ccucuccccu     2220

gcccaggaau gugcaaggcc agggcauggg ggcaaauaug acccaguuuu gggaacaccg     2280

acaaacccag cccuggcgcu gagccucucu accccagguc agacggacag aaagacagau     2340

cacagguaca gggaugagga caccggcucu gaccaggagu uuggggagcu ucaggacauu     2400

gcugugcuuu ggggauuccc uccacaugcu gcacgcgcau cucgccccca ggggcacugc     2460

cuggaagauu caggagccug ggcggccuuc gcuuacucuc accugcuucu gaguugccca     2520

ggagaccacu ggcagauguc ccggcgaaga gaagagacac auuguuggaa gaagcagccc     2580

augacagcuc cccuuccugg gacucgcccu cauccucuuc cugcuccccu uccuggggug     2640

cagccuaaaa ggaccuaugu ccucacacca uugaaaccac uaguucuguc cccccaggag     2700

accugguugu guguguguga gugguugacc uuccuccauc cccugguccu ucccuucccu     2760

ucccgaggca cagagagaca gggcaggauc cacgugccca uuguggaggc agagaaaaga     2820

gaaaguguuu uauauacggu acuuauuuaa uaucccuuuu uaauuagaaa uuaaaacagu     2880

uaauuuaauu aaagaguagg guuuuuuuuc aguauucuug guuaauauuu aauuucaacu     2940

auuuaugaga uguaucuuuu gcucucucuu gcucucuuau uuguaccggu uuuuguauau     3000

aaaauucaug uuuccaaucu cucucucccu gaucggugac agucacuagc uuaucuugaa     3060

cagauauuua auuuugcuaa cacucagcuc ugcccucccc gauccccugg cuccccagca     3120

cacauuccuu ugaaauaagg uuucaauaua caucuacaua cuauauauau auuuggcaac     3180

uuguauuugu guguauauau auauauauau guuuauguau auaugugauu cugauaaaau     3240

agacauugcu auucuguuuu uuauauguaa aaacaaaaca agaaaaaaua gagaauucua     3300

cauacuaaau cucucuccuu uuuuaauuuu aauauuuguu aucauuuauu uauuggugcu     3360

acuguuuauc cguaauaauu guggggaaaa gauauuaaca ucacgucuuu gucucuagug     3420

caguuuuucg agauauuccg uaguacauau uuauuuuuaa acaacgacaa agaaauacag     3480

auauaucuua aaaaaaaaaa agcauuuugu auuaaagaau uuaauucuga ucucaaa        3537


<210>  12
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Met 
        


<210>  13
<211>  3502
<212>  RNA
<213>  Homo sapiens

<400>  13
gcggaggcuu ggggcagccg gguagcucgg aggucguggc gcugggggcu agcaccagcg       60

cucugucggg aggcgcagcg guuaggugga ccggucagcg gacucaccgg ccagggcgcu      120

cggugcugga auuugauauu cauugauccg gguuuuaucc cucuucuuuu uucuuaaaca      180

uuuuuuuuua aaacuguauu guuucucguu uuaauuuauu uuugcuugcc auuccccacu      240

ugaaucgggc cgacggcuug gggagauugc ucuacuuccc caaaucacug uggauuuugg      300

aaaccagcag aaagaggaaa gagguagcaa gagcuccaga gagaagucga ggaagagaga      360

gacgggguca gagagagcgc gcgggcgugc gagcagcgaa agcgacaggg gcaaagugag      420

ugaccugcuu uuggggguga ccgccggagc gcggcgugag cccucccccu ugggaucccg      480

cagcugacca gucgcgcuga cggacagaca gacagacacc gcccccagcc ccagcuacca      540

ccuccucccc ggccggcggc ggacagugga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg uggagggggu cggggcucgc ggcgucgcac ugaaacuuuu      660

cguccaacuu cugggcuguu cucgcuucgg aggagccgug guccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gugcuagcuc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag uggcgacucg gcgcucggaa      840

gccgggcuca uggacgggug aggcggcggu gugcgcagac agugcuccag ccgcgcgcgc      900

uccccaggcc cuggcccggg ccucgggccg gggaggaaga guagcucgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

ucgggccucc gaaaccauga acuuucugcu gucuugggug cauuggagcc uugccuugcu     1080

gcucuaccuc caccaugcca agugguccca ggcugcaccc auggcagaag gaggagggca     1140

gaaucaucac gaagugguga aguucaugga ugucuaucag cgcagcuacu gccauccaau     1200

cgagacccug guggacaucu uccaggagua cccugaugag aucgaguaca ucuucaagcc     1260

auccugugug ccccugaugc gaugcggggg cugcugcaau gacgagggcc uggagugugu     1320

gcccacugag gaguccaaca ucaccaugca gauuaugcgg aucaaaccuc accaaggcca     1380

gcacauagga gagaugagcu uccuacagca caacaaaugu gaaugcagac caaagaaaga     1440

uagagcaaga caagaaaauc ccugugggcc uugcucagag cggagaaagc auuuguuugu     1500

acaagauccg cagacgugua aauguuccug caaaaacaca gacucgcguu gcaagaugug     1560

acaagccgag gcggugagcc gggcaggagg aaggagccuc ccucaggguu ucgggaacca     1620

gaucucucac caggaaagac ugauacagaa cgaucgauac agaaaccacg cugccgccac     1680

cacaccauca ccaucgacag aacaguccuu aauccagaaa ccugaaauga aggaagagga     1740

gacucugcgc agagcacuuu ggguccggag ggcgagacuc cggcggaagc auucccgggc     1800

gggugaccca gcacgguccc ucuuggaauu ggauucgcca uuuuauuuuu cuugcugcua     1860

aaucaccgag cccggaagau uagagaguuu uauuucuggg auuccuguag acacacccac     1920

ccacauacau acauuuauau auauauauau uauauauaua uaaaaauaaa uaucucuauu     1980

uuauauauau aaaauauaua uauucuuuuu uuaaauuaac agugcuaaug uuauuggugu     2040

cuucacugga uguauuugac ugcuguggac uugaguuggg aggggaaugu ucccacucag     2100

auccugacag ggaagaggag gagaugagag acucuggcau gaucuuuuuu uugucccacu     2160

ugguggggcc aggguccucu ccccugccca ggaaugugca aggccagggc augggggcaa     2220

auaugaccca guuuugggaa caccgacaaa cccagcccug gcgcugagcc ucucuacccc     2280

aggucagacg gacagaaaga cagaucacag guacagggau gaggacaccg gcucugacca     2340

ggaguuuggg gagcuucagg acauugcugu gcuuugggga uucccuccac augcugcacg     2400

cgcaucucgc ccccaggggc acugccugga agauucagga gccugggcgg ccuucgcuua     2460

cucucaccug cuucugaguu gcccaggaga ccacuggcag augucccggc gaagagaaga     2520

gacacauugu uggaagaagc agcccaugac agcuccccuu ccugggacuc gcccucaucc     2580

ucuuccugcu ccccuuccug gggugcagcc uaaaaggacc uauguccuca caccauugaa     2640

accacuaguu cugucccccc aggagaccug guugugugug ugugaguggu ugaccuuccu     2700

ccauccccug guccuucccu ucccuucccg aggcacagag agacagggca ggauccacgu     2760

gcccauugug gaggcagaga aaagagaaag uguuuuauau acgguacuua uuuaauaucc     2820

cuuuuuaauu agaaauuaaa acaguuaauu uaauuaaaga guaggguuuu uuuucaguau     2880

ucuugguuaa uauuuaauuu caacuauuua ugagauguau cuuuugcucu cucuugcucu     2940

cuuauuugua ccgguuuuug uauauaaaau ucauguuucc aaucucucuc ucccugaucg     3000

gugacaguca cuagcuuauc uugaacagau auuuaauuuu gcuaacacuc agcucugccc     3060

uccccgaucc ccuggcuccc cagcacacau uccuuugaaa uaagguuuca auauacaucu     3120

acauacuaua uauauauuug gcaacuugua uuugugugua uauauauaua uauauguuua     3180

uguauauaug ugauucugau aaaauagaca uugcuauucu guuuuuuaua uguaaaaaca     3240

aaacaagaaa aaauagagaa uucuacauac uaaaucucuc uccuuuuuua auuuuaauau     3300

uuguuaucau uuauuuauug gugcuacugu uuauccguaa uaauuguggg gaaaagauau     3360

uaacaucacg ucuuugucuc uagugcaguu uuucgagaua uuccguagua cauauuuauu     3420

uuuaaacaac gacaaagaaa uacagauaua ucuuaaaaaa aaaaaagcau uuuguauuaa     3480

agaauuuaau ucugaucuca aa                                              3502


<210>  14
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Cys Asp Lys Pro Arg Arg 
                325         


<210>  15
<211>  3405
<212>  RNA
<213>  Homo sapiens

<400>  15
gcggaggcuu ggggcagccg gguagcucgg aggucguggc gcugggggcu agcaccagcg       60

cucugucggg aggcgcagcg guuaggugga ccggucagcg gacucaccgg ccagggcgcu      120

cggugcugga auuugauauu cauugauccg gguuuuaucc cucuucuuuu uucuuaaaca      180

uuuuuuuuua aaacuguauu guuucucguu uuaauuuauu uuugcuugcc auuccccacu      240

ugaaucgggc cgacggcuug gggagauugc ucuacuuccc caaaucacug uggauuuugg      300

aaaccagcag aaagaggaaa gagguagcaa gagcuccaga gagaagucga ggaagagaga      360

gacgggguca gagagagcgc gcgggcgugc gagcagcgaa agcgacaggg gcaaagugag      420

ugaccugcuu uuggggguga ccgccggagc gcggcgugag cccucccccu ugggaucccg      480

cagcugacca gucgcgcuga cggacagaca gacagacacc gcccccagcc ccagcuacca      540

ccuccucccc ggccggcggc ggacagugga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg uggagggggu cggggcucgc ggcgucgcac ugaaacuuuu      660

cguccaacuu cugggcuguu cucgcuucgg aggagccgug guccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gugcuagcuc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag uggcgacucg gcgcucggaa      840

gccgggcuca uggacgggug aggcggcggu gugcgcagac agugcuccag ccgcgcgcgc      900

uccccaggcc cuggcccggg ccucgggccg gggaggaaga guagcucgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

ucgggccucc gaaaccauga acuuucugcu gucuugggug cauuggagcc uugccuugcu     1080

gcucuaccuc caccaugcca agugguccca ggcugcaccc auggcagaag gaggagggca     1140

gaaucaucac gaagugguga aguucaugga ugucuaucag cgcagcuacu gccauccaau     1200

cgagacccug guggacaucu uccaggagua cccugaugag aucgaguaca ucuucaagcc     1260

auccugugug ccccugaugc gaugcggggg cugcugcaau gacgagggcc uggagugugu     1320

gcccacugag gaguccaaca ucaccaugca gauuaugcgg aucaaaccuc accaaggcca     1380

gcacauagga gagaugagcu uccuacagca caacaaaugu gaaugcagac caaagaaaga     1440

uagagcaaga caagaaaaau gugacaagcc gaggcgguga gccgggcagg aggaaggagc     1500

cucccucagg guuucgggaa ccagaucucu caccaggaaa gacugauaca gaacgaucga     1560

uacagaaacc acgcugccgc caccacacca ucaccaucga cagaacaguc cuuaauccag     1620

aaaccugaaa ugaaggaaga ggagacucug cgcagagcac uuuggguccg gagggcgaga     1680

cuccggcgga agcauucccg ggcgggugac ccagcacggu cccucuugga auuggauucg     1740

ccauuuuauu uuucuugcug cuaaaucacc gagcccggaa gauuagagag uuuuauuucu     1800

gggauuccug uagacacacc cacccacaua cauacauuua uauauauaua uauuauauau     1860

auauaaaaau aaauaucucu auuuuauaua uauaaaauau auauauucuu uuuuuaaauu     1920

aacagugcua auguuauugg ugucuucacu ggauguauuu gacugcugug gacuugaguu     1980

gggaggggaa uguucccacu cagauccuga cagggaagag gaggagauga gagacucugg     2040

caugaucuuu uuuuuguccc acuugguggg gccagggucc ucuccccugc ccaggaaugu     2100

gcaaggccag ggcauggggg caaauaugac ccaguuuugg gaacaccgac aaacccagcc     2160

cuggcgcuga gccucucuac cccaggucag acggacagaa agacagauca cagguacagg     2220

gaugaggaca ccggcucuga ccaggaguuu ggggagcuuc aggacauugc ugugcuuugg     2280

ggauucccuc cacaugcugc acgcgcaucu cgcccccagg ggcacugccu ggaagauuca     2340

ggagccuggg cggccuucgc uuacucucac cugcuucuga guugcccagg agaccacugg     2400

cagauguccc ggcgaagaga agagacacau uguuggaaga agcagcccau gacagcuccc     2460

cuuccuggga cucgcccuca uccucuuccu gcuccccuuc cuggggugca gccuaaaagg     2520

accuaugucc ucacaccauu gaaaccacua guucuguccc cccaggagac cugguugugu     2580

gugugugagu gguugaccuu ccuccauccc cugguccuuc ccuucccuuc ccgaggcaca     2640

gagagacagg gcaggaucca cgugcccauu guggaggcag agaaaagaga aaguguuuua     2700

uauacgguac uuauuuaaua ucccuuuuua auuagaaauu aaaacaguua auuuaauuaa     2760

agaguagggu uuuuuuucag uauucuuggu uaauauuuaa uuucaacuau uuaugagaug     2820

uaucuuuugc ucucucuugc ucucuuauuu guaccgguuu uuguauauaa aauucauguu     2880

uccaaucucu cucucccuga ucggugacag ucacuagcuu aucuugaaca gauauuuaau     2940

uuugcuaaca cucagcucug cccuccccga uccccuggcu ccccagcaca cauuccuuug     3000

aaauaagguu ucaauauaca ucuacauacu auauauauau uuggcaacuu guauuugugu     3060

guauauauau auauauaugu uuauguauau augugauucu gauaaaauag acauugcuau     3120

ucuguuuuuu auauguaaaa acaaaacaag aaaaaauaga gaauucuaca uacuaaaucu     3180

cucuccuuuu uuaauuuuaa uauuuguuau cauuuauuua uuggugcuac uguuuauccg     3240

uaauaauugu ggggaaaaga uauuaacauc acgucuuugu cucuagugca guuuuucgag     3300

auauuccgua guacauauuu auuuuuaaac aacgacaaag aaauacagau auaucuuaaa     3360

aaaaaaaaag cauuuuguau uaaagaauuu aauucugauc ucaaa                     3405


<210>  16
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Ser Leu Thr 
        355                 360                 365             


Arg Lys Asp 
    370     


<210>  17
<211>  3471
<212>  RNA
<213>  Homo sapiens

<400>  17
gcggaggcuu ggggcagccg gguagcucgg aggucguggc gcugggggcu agcaccagcg       60

cucugucggg aggcgcagcg guuaggugga ccggucagcg gacucaccgg ccagggcgcu      120

cggugcugga auuugauauu cauugauccg gguuuuaucc cucuucuuuu uucuuaaaca      180

uuuuuuuuua aaacuguauu guuucucguu uuaauuuauu uuugcuugcc auuccccacu      240

ugaaucgggc cgacggcuug gggagauugc ucuacuuccc caaaucacug uggauuuugg      300

aaaccagcag aaagaggaaa gagguagcaa gagcuccaga gagaagucga ggaagagaga      360

gacgggguca gagagagcgc gcgggcgugc gagcagcgaa agcgacaggg gcaaagugag      420

ugaccugcuu uuggggguga ccgccggagc gcggcgugag cccucccccu ugggaucccg      480

cagcugacca gucgcgcuga cggacagaca gacagacacc gcccccagcc ccagcuacca      540

ccuccucccc ggccggcggc ggacagugga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg uggagggggu cggggcucgc ggcgucgcac ugaaacuuuu      660

cguccaacuu cugggcuguu cucgcuucgg aggagccgug guccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gugcuagcuc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag uggcgacucg gcgcucggaa      840

gccgggcuca uggacgggug aggcggcggu gugcgcagac agugcuccag ccgcgcgcgc      900

uccccaggcc cuggcccggg ccucgggccg gggaggaaga guagcucgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

ucgggccucc gaaaccauga acuuucugcu gucuugggug cauuggagcc uugccuugcu     1080

gcucuaccuc caccaugcca agugguccca ggcugcaccc auggcagaag gaggagggca     1140

gaaucaucac gaagugguga aguucaugga ugucuaucag cgcagcuacu gccauccaau     1200

cgagacccug guggacaucu uccaggagua cccugaugag aucgaguaca ucuucaagcc     1260

auccugugug ccccugaugc gaugcggggg cugcugcaau gacgagggcc uggagugugu     1320

gcccacugag gaguccaaca ucaccaugca gauuaugcgg aucaaaccuc accaaggcca     1380

gcacauagga gagaugagcu uccuacagca caacaaaugu gaaugcagac caaagaaaga     1440

uagagcaaga caagaaaauc ccugugggcc uugcucagag cggagaaagc auuuguuugu     1500

acaagauccg cagacgugua aauguuccug caaaaacaca gacucgcguu gcaaggcgag     1560

gcagcuugag uuaaacgaac guacuugcag aucucucacc aggaaagacu gauacagaac     1620

gaucgauaca gaaaccacgc ugccgccacc acaccaucac caucgacaga acaguccuua     1680

auccagaaac cugaaaugaa ggaagaggag acucugcgca gagcacuuug gguccggagg     1740

gcgagacucc ggcggaagca uucccgggcg ggugacccag cacggucccu cuuggaauug     1800

gauucgccau uuuauuuuuc uugcugcuaa aucaccgagc ccggaagauu agagaguuuu     1860

auuucuggga uuccuguaga cacacccacc cacauacaua cauuuauaua uauauauauu     1920

auauauauau aaaaauaaau aucucuauuu uauauauaua aaauauauau auucuuuuuu     1980

uaaauuaaca gugcuaaugu uauugguguc uucacuggau guauuugacu gcuguggacu     2040

ugaguuggga ggggaauguu cccacucaga uccugacagg gaagaggagg agaugagaga     2100

cucuggcaug aucuuuuuuu ugucccacuu gguggggcca ggguccucuc cccugcccag     2160

gaaugugcaa ggccagggca ugggggcaaa uaugacccag uuuugggaac accgacaaac     2220

ccagcccugg cgcugagccu cucuacccca ggucagacgg acagaaagac agaucacagg     2280

uacagggaug aggacaccgg cucugaccag gaguuugggg agcuucagga cauugcugug     2340

cuuuggggau ucccuccaca ugcugcacgc gcaucucgcc cccaggggca cugccuggaa     2400

gauucaggag ccugggcggc cuucgcuuac ucucaccugc uucugaguug cccaggagac     2460

cacuggcaga ugucccggcg aagagaagag acacauuguu ggaagaagca gcccaugaca     2520

gcuccccuuc cugggacucg cccucauccu cuuccugcuc cccuuccugg ggugcagccu     2580

aaaaggaccu auguccucac accauugaaa ccacuaguuc ugucccccca ggagaccugg     2640

uugugugugu gugagugguu gaccuuccuc cauccccugg uccuucccuu cccuucccga     2700

ggcacagaga gacagggcag gauccacgug cccauugugg aggcagagaa aagagaaagu     2760

guuuuauaua cgguacuuau uuaauauccc uuuuuaauua gaaauuaaaa caguuaauuu     2820

aauuaaagag uaggguuuuu uuucaguauu cuugguuaau auuuaauuuc aacuauuuau     2880

gagauguauc uuuugcucuc ucuugcucuc uuauuuguac cgguuuuugu auauaaaauu     2940

cauguuucca aucucucucu cccugaucgg ugacagucac uagcuuaucu ugaacagaua     3000

uuuaauuuug cuaacacuca gcucugcccu ccccgauccc cuggcucccc agcacacauu     3060

ccuuugaaau aagguuucaa uauacaucua cauacuauau auauauuugg caacuuguau     3120

uuguguguau auauauauau auauguuuau guauauaugu gauucugaua aaauagacau     3180

ugcuauucug uuuuuuauau guaaaaacaa aacaagaaaa aauagagaau ucuacauacu     3240

aaaucucucu ccuuuuuuaa uuuuaauauu uguuaucauu uauuuauugg ugcuacuguu     3300

uauccguaau aauugugggg aaaagauauu aacaucacgu cuuugucucu agugcaguuu     3360

uucgagauau uccguaguac auauuuauuu uuaaacaacg acaaagaaau acagauauau     3420

cuuaaaaaaa aaaaagcauu uuguauuaaa gaauuuaauu cugaucucaa a              3471


<210>  18
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Cys Asp Lys Pro Arg Arg 
305                 310                 315         


<210>  19
<211>  3375
<212>  RNA
<213>  Homo sapiens

<400>  19
gcggaggcuu ggggcagccg gguagcucgg aggucguggc gcugggggcu agcaccagcg       60

cucugucggg aggcgcagcg guuaggugga ccggucagcg gacucaccgg ccagggcgcu      120

cggugcugga auuugauauu cauugauccg gguuuuaucc cucuucuuuu uucuuaaaca      180

uuuuuuuuua aaacuguauu guuucucguu uuaauuuauu uuugcuugcc auuccccacu      240

ugaaucgggc cgacggcuug gggagauugc ucuacuuccc caaaucacug uggauuuugg      300

aaaccagcag aaagaggaaa gagguagcaa gagcuccaga gagaagucga ggaagagaga      360

gacgggguca gagagagcgc gcgggcgugc gagcagcgaa agcgacaggg gcaaagugag      420

ugaccugcuu uuggggguga ccgccggagc gcggcgugag cccucccccu ugggaucccg      480

cagcugacca gucgcgcuga cggacagaca gacagacacc gcccccagcc ccagcuacca      540

ccuccucccc ggccggcggc ggacagugga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg uggagggggu cggggcucgc ggcgucgcac ugaaacuuuu      660

cguccaacuu cugggcuguu cucgcuucgg aggagccgug guccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gugcuagcuc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag uggcgacucg gcgcucggaa      840

gccgggcuca uggacgggug aggcggcggu gugcgcagac agugcuccag ccgcgcgcgc      900

uccccaggcc cuggcccggg ccucgggccg gggaggaaga guagcucgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

ucgggccucc gaaaccauga acuuucugcu gucuugggug cauuggagcc uugccuugcu     1080

gcucuaccuc caccaugcca agugguccca ggcugcaccc auggcagaag gaggagggca     1140

gaaucaucac gaagugguga aguucaugga ugucuaucag cgcagcuacu gccauccaau     1200

cgagacccug guggacaucu uccaggagua cccugaugag aucgaguaca ucuucaagcc     1260

auccugugug ccccugaugc gaugcggggg cugcugcaau gacgagggcc uggagugugu     1320

gcccacugag gaguccaaca ucaccaugca gauuaugcgg aucaaaccuc accaaggcca     1380

gcacauagga gagaugagcu uccuacagca caacaaaugu gaaugcagau gugacaagcc     1440

gaggcgguga gccgggcagg aggaaggagc cucccucagg guuucgggaa ccagaucucu     1500

caccaggaaa gacugauaca gaacgaucga uacagaaacc acgcugccgc caccacacca     1560

ucaccaucga cagaacaguc cuuaauccag aaaccugaaa ugaaggaaga ggagacucug     1620

cgcagagcac uuuggguccg gagggcgaga cuccggcgga agcauucccg ggcgggugac     1680

ccagcacggu cccucuugga auuggauucg ccauuuuauu uuucuugcug cuaaaucacc     1740

gagcccggaa gauuagagag uuuuauuucu gggauuccug uagacacacc cacccacaua     1800

cauacauuua uauauauaua uauuauauau auauaaaaau aaauaucucu auuuuauaua     1860

uauaaaauau auauauucuu uuuuuaaauu aacagugcua auguuauugg ugucuucacu     1920

ggauguauuu gacugcugug gacuugaguu gggaggggaa uguucccacu cagauccuga     1980

cagggaagag gaggagauga gagacucugg caugaucuuu uuuuuguccc acuugguggg     2040

gccagggucc ucuccccugc ccaggaaugu gcaaggccag ggcauggggg caaauaugac     2100

ccaguuuugg gaacaccgac aaacccagcc cuggcgcuga gccucucuac cccaggucag     2160

acggacagaa agacagauca cagguacagg gaugaggaca ccggcucuga ccaggaguuu     2220

ggggagcuuc aggacauugc ugugcuuugg ggauucccuc cacaugcugc acgcgcaucu     2280

cgcccccagg ggcacugccu ggaagauuca ggagccuggg cggccuucgc uuacucucac     2340

cugcuucuga guugcccagg agaccacugg cagauguccc ggcgaagaga agagacacau     2400

uguuggaaga agcagcccau gacagcuccc cuuccuggga cucgcccuca uccucuuccu     2460

gcuccccuuc cuggggugca gccuaaaagg accuaugucc ucacaccauu gaaaccacua     2520

guucuguccc cccaggagac cugguugugu gugugugagu gguugaccuu ccuccauccc     2580

cugguccuuc ccuucccuuc ccgaggcaca gagagacagg gcaggaucca cgugcccauu     2640

guggaggcag agaaaagaga aaguguuuua uauacgguac uuauuuaaua ucccuuuuua     2700

auuagaaauu aaaacaguua auuuaauuaa agaguagggu uuuuuuucag uauucuuggu     2760

uaauauuuaa uuucaacuau uuaugagaug uaucuuuugc ucucucuugc ucucuuauuu     2820

guaccgguuu uuguauauaa aauucauguu uccaaucucu cucucccuga ucggugacag     2880

ucacuagcuu aucuugaaca gauauuuaau uuugcuaaca cucagcucug cccuccccga     2940

uccccuggcu ccccagcaca cauuccuuug aaauaagguu ucaauauaca ucuacauacu     3000

auauauauau uuggcaacuu guauuugugu guauauauau auauauaugu uuauguauau     3060

augugauucu gauaaaauag acauugcuau ucuguuuuuu auauguaaaa acaaaacaag     3120

aaaaaauaga gaauucuaca uacuaaaucu cucuccuuuu uuaauuuuaa uauuuguuau     3180

cauuuauuua uuggugcuac uguuuauccg uaauaauugu ggggaaaaga uauuaacauc     3240

acgucuuugu cucuagugca guuuuucgag auauuccgua guacauauuu auuuuuaaac     3300

aacgacaaag aaauacagau auaucuuaaa aaaaaaaaag cauuuuguau uaaagaauuu     3360

aauucugauc ucaaa                                                      3375


<210>  20
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 
                165                 170                 175     


Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys 
            180                 185                 190         


His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn 
        195                 200                 205             


Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr 
    210                 215                 220                 


Cys Arg Cys Asp Lys Pro Arg Arg 
225                 230         


<210>  21
<211>  3677
<212>  RNA
<213>  Homo sapiens

<400>  21
ucgcggaggc uuggggcagc cggguagcuc ggaggucgug gcgcuggggg cuagcaccag       60

cgcucugucg ggaggcgcag cgguuaggug gaccggucag cggacucacc ggccagggcg      120

cucggugcug gaauuugaua uucauugauc cggguuuuau cccucuucuu uuuucuuaaa      180

cauuuuuuuu uaaaacugua uuguuucucg uuuuaauuua uuuuugcuug ccauucccca      240

cuugaaucgg gccgacggcu uggggagauu gcucuacuuc cccaaaucac uguggauuuu      300

ggaaaccagc agaaagagga aagagguagc aagagcucca gagagaaguc gaggaagaga      360

gagacggggu cagagagagc gcgcgggcgu gcgagcagcg aaagcgacag gggcaaagug      420

agugaccugc uuuugggggu gaccgccgga gcgcggcgug agcccucccc cuugggaucc      480

cgcagcugac cagucgcgcu gacggacaga cagacagaca ccgcccccag ccccagcuac      540

caccuccucc ccggccggcg gcggacagug gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg gguggagggg gucggggcuc gcggcgucgc acugaaacuu      660

uucguccaac uucugggcug uucucgcuuc ggaggagccg ugguccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagugcuagc ucgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc aguggcgacu cggcgcucgg      840

aagccgggcu cauggacggg ugaggcggcg gugugcgcag acagugcucc agccgcgcgc      900

gcuccccagg cccuggcccg ggccucgggc cggggaggaa gaguagcucg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggucgggccu ccgaaaccau gaacuuucug cugucuuggg ugcauuggag ccuugccuug     1080

cugcucuacc uccaccaugc caaguggucc caggcugcac ccauggcaga aggaggaggg     1140

cagaaucauc acgaaguggu gaaguucaug gaugucuauc agcgcagcua cugccaucca     1200

aucgagaccc ugguggacau cuuccaggag uacccugaug agaucgagua caucuucaag     1260

ccauccugug ugccccugau gcgaugcggg ggcugcugca augacgaggg ccuggagugu     1320

gugcccacug aggaguccaa caucaccaug cagauuaugc ggaucaaacc ucaccaaggc     1380

cagcacauag gagagaugag cuuccuacag cacaacaaau gugaaugcag accaaagaaa     1440

gauagagcaa gacaagaaaa aaaaucaguu cgaggaaagg gaaaggggca aaaacgaaag     1500

cgcaagaaau cccgguauaa guccuggagc guguacguug gugcccgcug cugucuaaug     1560

cccuggagcc ucccuggccc ccaucccugu gggccuugcu cagagcggag aaagcauuug     1620

uuuguacaag auccgcagac guguaaaugu uccugcaaaa acacagacuc gcguugcaag     1680

gcgaggcagc uugaguuaaa cgaacguacu ugcagaugug acaagccgag gcggugagcc     1740

gggcaggagg aaggagccuc ccucaggguu ucgggaacca gaucucucac caggaaagac     1800

ugauacagaa cgaucgauac agaaaccacg cugccgccac cacaccauca ccaucgacag     1860

aacaguccuu aauccagaaa ccugaaauga aggaagagga gacucugcgc agagcacuuu     1920

ggguccggag ggcgagacuc cggcggaagc auucccgggc gggugaccca gcacgguccc     1980

ucuuggaauu ggauucgcca uuuuauuuuu cuugcugcua aaucaccgag cccggaagau     2040

uagagaguuu uauuucuggg auuccuguag acacacccac ccacauacau acauuuauau     2100

auauauauau uauauauaua uaaaaauaaa uaucucuauu uuauauauau aaaauauaua     2160

uauucuuuuu uuaaauuaac agugcuaaug uuauuggugu cuucacugga uguauuugac     2220

ugcuguggac uugaguuggg aggggaaugu ucccacucag auccugacag ggaagaggag     2280

gagaugagag acucuggcau gaucuuuuuu uugucccacu ugguggggcc aggguccucu     2340

ccccugccca ggaaugugca aggccagggc augggggcaa auaugaccca guuuugggaa     2400

caccgacaaa cccagcccug gcgcugagcc ucucuacccc aggucagacg gacagaaaga     2460

cagaucacag guacagggau gaggacaccg gcucugacca ggaguuuggg gagcuucagg     2520

acauugcugu gcuuugggga uucccuccac augcugcacg cgcaucucgc ccccaggggc     2580

acugccugga agauucagga gccugggcgg ccuucgcuua cucucaccug cuucugaguu     2640

gcccaggaga ccacuggcag augucccggc gaagagaaga gacacauugu uggaagaagc     2700

agcccaugac agcuccccuu ccugggacuc gcccucaucc ucuuccugcu ccccuuccug     2760

gggugcagcc uaaaaggacc uauguccuca caccauugaa accacuaguu cugucccccc     2820

aggagaccug guugugugug ugugaguggu ugaccuuccu ccauccccug guccuucccu     2880

ucccuucccg aggcacagag agacagggca ggauccacgu gcccauugug gaggcagaga     2940

aaagagaaag uguuuuauau acgguacuua uuuaauaucc cuuuuuaauu agaaauuaaa     3000

acaguuaauu uaauuaaaga guaggguuuu uuuucaguau ucuugguuaa uauuuaauuu     3060

caacuauuua ugagauguau cuuuugcucu cucuugcucu cuuauuugua ccgguuuuug     3120

uauauaaaau ucauguuucc aaucucucuc ucccugaucg gugacaguca cuagcuuauc     3180

uugaacagau auuuaauuuu gcuaacacuc agcucugccc uccccgaucc ccuggcuccc     3240

cagcacacau uccuuugaaa uaagguuuca auauacaucu acauacuaua uauauauuug     3300

gcaacuugua uuugugugua uauauauaua uauauguuua uguauauaug ugauucugau     3360

aaaauagaca uugcuauucu guuuuuuaua uguaaaaaca aaacaagaaa aaauagagaa     3420

uucuacauac uaaaucucuc uccuuuuuua auuuuaauau uuguuaucau uuauuuauug     3480

gugcuacugu uuauccguaa uaauuguggg gaaaagauau uaacaucacg ucuuugucuc     3540

uagugcaguu uuucgagaua uuccguagua cauauuuauu uuuaaacaac gacaaagaaa     3600

uacagauaua ucuuaaaaaa aaaaaagcau uuuguauuaa agaauuuaau ucugaucuca     3660

aaaaaaaaaa aaaaaaa                                                    3677


<210>  22
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His 
                165                 170                 175     


Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr 
            180                 185                 190         


Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys 
        195                 200                 205             


Arg Cys Asp Lys Pro Arg Arg 
    210                 215 


<210>  23
<211>  3626
<212>  RNA
<213>  Homo sapiens

<400>  23
ucgcggaggc uuggggcagc cggguagcuc ggaggucgug gcgcuggggg cuagcaccag       60

cgcucugucg ggaggcgcag cgguuaggug gaccggucag cggacucacc ggccagggcg      120

cucggugcug gaauuugaua uucauugauc cggguuuuau cccucuucuu uuuucuuaaa      180

cauuuuuuuu uaaaacugua uuguuucucg uuuuaauuua uuuuugcuug ccauucccca      240

cuugaaucgg gccgacggcu uggggagauu gcucuacuuc cccaaaucac uguggauuuu      300

ggaaaccagc agaaagagga aagagguagc aagagcucca gagagaaguc gaggaagaga      360

gagacggggu cagagagagc gcgcgggcgu gcgagcagcg aaagcgacag gggcaaagug      420

agugaccugc uuuugggggu gaccgccgga gcgcggcgug agcccucccc cuugggaucc      480

cgcagcugac cagucgcgcu gacggacaga cagacagaca ccgcccccag ccccagcuac      540

caccuccucc ccggccggcg gcggacagug gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg gguggagggg gucggggcuc gcggcgucgc acugaaacuu      660

uucguccaac uucugggcug uucucgcuuc ggaggagccg ugguccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagugcuagc ucgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc aguggcgacu cggcgcucgg      840

aagccgggcu cauggacggg ugaggcggcg gugugcgcag acagugcucc agccgcgcgc      900

gcuccccagg cccuggcccg ggccucgggc cggggaggaa gaguagcucg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggucgggccu ccgaaaccau gaacuuucug cugucuuggg ugcauuggag ccuugccuug     1080

cugcucuacc uccaccaugc caaguggucc caggcugcac ccauggcaga aggaggaggg     1140

cagaaucauc acgaaguggu gaaguucaug gaugucuauc agcgcagcua cugccaucca     1200

aucgagaccc ugguggacau cuuccaggag uacccugaug agaucgagua caucuucaag     1260

ccauccugug ugccccugau gcgaugcggg ggcugcugca augacgaggg ccuggagugu     1320

gugcccacug aggaguccaa caucaccaug cagauuaugc ggaucaaacc ucaccaaggc     1380

cagcacauag gagagaugag cuuccuacag cacaacaaau gugaaugcag accaaagaaa     1440

gauagagcaa gacaagaaaa aaaaucaguu cgaggaaagg gaaaggggca aaaacgaaag     1500

cgcaagaaau cccgguauaa guccuggagc guucccugug ggccuugcuc agagcggaga     1560

aagcauuugu uuguacaaga uccgcagacg uguaaauguu ccugcaaaaa cacagacucg     1620

cguugcaagg cgaggcagcu ugaguuaaac gaacguacuu gcagauguga caagccgagg     1680

cggugagccg ggcaggagga aggagccucc cucaggguuu cgggaaccag aucucucacc     1740

aggaaagacu gauacagaac gaucgauaca gaaaccacgc ugccgccacc acaccaucac     1800

caucgacaga acaguccuua auccagaaac cugaaaugaa ggaagaggag acucugcgca     1860

gagcacuuug gguccggagg gcgagacucc ggcggaagca uucccgggcg ggugacccag     1920

cacggucccu cuuggaauug gauucgccau uuuauuuuuc uugcugcuaa aucaccgagc     1980

ccggaagauu agagaguuuu auuucuggga uuccuguaga cacacccacc cacauacaua     2040

cauuuauaua uauauauauu auauauauau aaaaauaaau aucucuauuu uauauauaua     2100

aaauauauau auucuuuuuu uaaauuaaca gugcuaaugu uauugguguc uucacuggau     2160

guauuugacu gcuguggacu ugaguuggga ggggaauguu cccacucaga uccugacagg     2220

gaagaggagg agaugagaga cucuggcaug aucuuuuuuu ugucccacuu gguggggcca     2280

ggguccucuc cccugcccag gaaugugcaa ggccagggca ugggggcaaa uaugacccag     2340

uuuugggaac accgacaaac ccagcccugg cgcugagccu cucuacccca ggucagacgg     2400

acagaaagac agaucacagg uacagggaug aggacaccgg cucugaccag gaguuugggg     2460

agcuucagga cauugcugug cuuuggggau ucccuccaca ugcugcacgc gcaucucgcc     2520

cccaggggca cugccuggaa gauucaggag ccugggcggc cuucgcuuac ucucaccugc     2580

uucugaguug cccaggagac cacuggcaga ugucccggcg aagagaagag acacauuguu     2640

ggaagaagca gcccaugaca gcuccccuuc cugggacucg cccucauccu cuuccugcuc     2700

cccuuccugg ggugcagccu aaaaggaccu auguccucac accauugaaa ccacuaguuc     2760

ugucccccca ggagaccugg uugugugugu gugagugguu gaccuuccuc cauccccugg     2820

uccuucccuu cccuucccga ggcacagaga gacagggcag gauccacgug cccauugugg     2880

aggcagagaa aagagaaagu guuuuauaua cgguacuuau uuaauauccc uuuuuaauua     2940

gaaauuaaaa caguuaauuu aauuaaagag uaggguuuuu uuucaguauu cuugguuaau     3000

auuuaauuuc aacuauuuau gagauguauc uuuugcucuc ucuugcucuc uuauuuguac     3060

cgguuuuugu auauaaaauu cauguuucca aucucucucu cccugaucgg ugacagucac     3120

uagcuuaucu ugaacagaua uuuaauuuug cuaacacuca gcucugcccu ccccgauccc     3180

cuggcucccc agcacacauu ccuuugaaau aagguuucaa uauacaucua cauacuauau     3240

auauauuugg caacuuguau uuguguguau auauauauau auauguuuau guauauaugu     3300

gauucugaua aaauagacau ugcuauucug uuuuuuauau guaaaaacaa aacaagaaaa     3360

aauagagaau ucuacauacu aaaucucucu ccuuuuuuaa uuuuaauauu uguuaucauu     3420

uauuuauugg ugcuacuguu uauccguaau aauugugggg aaaagauauu aacaucacgu     3480

cuuugucucu agugcaguuu uucgagauau uccguaguac auauuuauuu uuaaacaacg     3540

acaaagaaau acagauauau cuuaaaaaaa aaaaagcauu uuguauuaaa gaauuuaauu     3600

cugaucucaa aaaaaaaaaa aaaaaa                                          3626


<210>  24
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Pro 
145                 150                 155                 160 


Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro 
                165                 170                 175     


Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala 
            180                 185                 190         


Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg 
        195                 200                 205             


Arg 
    


<210>  25
<211>  3608
<212>  RNA
<213>  Homo sapiens

<400>  25
ucgcggaggc uuggggcagc cggguagcuc ggaggucgug gcgcuggggg cuagcaccag       60

cgcucugucg ggaggcgcag cgguuaggug gaccggucag cggacucacc ggccagggcg      120

cucggugcug gaauuugaua uucauugauc cggguuuuau cccucuucuu uuuucuuaaa      180

cauuuuuuuu uaaaacugua uuguuucucg uuuuaauuua uuuuugcuug ccauucccca      240

cuugaaucgg gccgacggcu uggggagauu gcucuacuuc cccaaaucac uguggauuuu      300

ggaaaccagc agaaagagga aagagguagc aagagcucca gagagaaguc gaggaagaga      360

gagacggggu cagagagagc gcgcgggcgu gcgagcagcg aaagcgacag gggcaaagug      420

agugaccugc uuuugggggu gaccgccgga gcgcggcgug agcccucccc cuugggaucc      480

cgcagcugac cagucgcgcu gacggacaga cagacagaca ccgcccccag ccccagcuac      540

caccuccucc ccggccggcg gcggacagug gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg gguggagggg gucggggcuc gcggcgucgc acugaaacuu      660

uucguccaac uucugggcug uucucgcuuc ggaggagccg ugguccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagugcuagc ucgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc aguggcgacu cggcgcucgg      840

aagccgggcu cauggacggg ugaggcggcg gugugcgcag acagugcucc agccgcgcgc      900

gcuccccagg cccuggcccg ggccucgggc cggggaggaa gaguagcucg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggucgggccu ccgaaaccau gaacuuucug cugucuuggg ugcauuggag ccuugccuug     1080

cugcucuacc uccaccaugc caaguggucc caggcugcac ccauggcaga aggaggaggg     1140

cagaaucauc acgaaguggu gaaguucaug gaugucuauc agcgcagcua cugccaucca     1200

aucgagaccc ugguggacau cuuccaggag uacccugaug agaucgagua caucuucaag     1260

ccauccugug ugccccugau gcgaugcggg ggcugcugca augacgaggg ccuggagugu     1320

gugcccacug aggaguccaa caucaccaug cagauuaugc ggaucaaacc ucaccaaggc     1380

cagcacauag gagagaugag cuuccuacag cacaacaaau gugaaugcag accaaagaaa     1440

gauagagcaa gacaagaaaa aaaaucaguu cgaggaaagg gaaaggggca aaaacgaaag     1500

cgcaagaaau cccgucccug ugggccuugc ucagagcgga gaaagcauuu guuuguacaa     1560

gauccgcaga cguguaaaug uuccugcaaa aacacagacu cgcguugcaa ggcgaggcag     1620

cuugaguuaa acgaacguac uugcagaugu gacaagccga ggcggugagc cgggcaggag     1680

gaaggagccu cccucagggu uucgggaacc agaucucuca ccaggaaaga cugauacaga     1740

acgaucgaua cagaaaccac gcugccgcca ccacaccauc accaucgaca gaacaguccu     1800

uaauccagaa accugaaaug aaggaagagg agacucugcg cagagcacuu uggguccgga     1860

gggcgagacu ccggcggaag cauucccggg cgggugaccc agcacggucc cucuuggaau     1920

uggauucgcc auuuuauuuu ucuugcugcu aaaucaccga gcccggaaga uuagagaguu     1980

uuauuucugg gauuccugua gacacaccca cccacauaca uacauuuaua uauauauaua     2040

uuauauauau auaaaaauaa auaucucuau uuuauauaua uaaaauauau auauucuuuu     2100

uuuaaauuaa cagugcuaau guuauuggug ucuucacugg auguauuuga cugcugugga     2160

cuugaguugg gaggggaaug uucccacuca gauccugaca gggaagagga ggagaugaga     2220

gacucuggca ugaucuuuuu uuugucccac uugguggggc caggguccuc uccccugccc     2280

aggaaugugc aaggccaggg caugggggca aauaugaccc aguuuuggga acaccgacaa     2340

acccagcccu ggcgcugagc cucucuaccc caggucagac ggacagaaag acagaucaca     2400

gguacaggga ugaggacacc ggcucugacc aggaguuugg ggagcuucag gacauugcug     2460

ugcuuugggg auucccucca caugcugcac gcgcaucucg cccccagggg cacugccugg     2520

aagauucagg agccugggcg gccuucgcuu acucucaccu gcuucugagu ugcccaggag     2580

accacuggca gaugucccgg cgaagagaag agacacauug uuggaagaag cagcccauga     2640

cagcuccccu uccugggacu cgcccucauc cucuuccugc uccccuuccu ggggugcagc     2700

cuaaaaggac cuauguccuc acaccauuga aaccacuagu ucuguccccc caggagaccu     2760

gguugugugu gugugagugg uugaccuucc uccauccccu gguccuuccc uucccuuccc     2820

gaggcacaga gagacagggc aggauccacg ugcccauugu ggaggcagag aaaagagaaa     2880

guguuuuaua uacgguacuu auuuaauauc ccuuuuuaau uagaaauuaa aacaguuaau     2940

uuaauuaaag aguaggguuu uuuuucagua uucuugguua auauuuaauu ucaacuauuu     3000

augagaugua ucuuuugcuc ucucuugcuc ucuuauuugu accgguuuuu guauauaaaa     3060

uucauguuuc caaucucucu cucccugauc ggugacaguc acuagcuuau cuugaacaga     3120

uauuuaauuu ugcuaacacu cagcucugcc cuccccgauc cccuggcucc ccagcacaca     3180

uuccuuugaa auaagguuuc aauauacauc uacauacuau auauauauuu ggcaacuugu     3240

auuugugugu auauauauau auauauguuu auguauauau gugauucuga uaaaauagac     3300

auugcuauuc uguuuuuuau auguaaaaac aaaacaagaa aaaauagaga auucuacaua     3360

cuaaaucucu cuccuuuuuu aauuuuaaua uuuguuauca uuuauuuauu ggugcuacug     3420

uuuauccgua auaauugugg ggaaaagaua uuaacaucac gucuuugucu cuagugcagu     3480

uuuucgagau auuccguagu acauauuuau uuuuaaacaa cgacaaagaa auacagauau     3540

aucuuaaaaa aaaaaaagca uuuuguauua aagaauuuaa uucugaucuc aaaaaaaaaa     3600

aaaaaaaa                                                              3608


<210>  26
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Met 
                165                 170                 


<210>  27
<211>  3519
<212>  RNA
<213>  Homo sapiens

<400>  27
ucgcggaggc uuggggcagc cggguagcuc ggaggucgug gcgcuggggg cuagcaccag       60

cgcucugucg ggaggcgcag cgguuaggug gaccggucag cggacucacc ggccagggcg      120

cucggugcug gaauuugaua uucauugauc cggguuuuau cccucuucuu uuuucuuaaa      180

cauuuuuuuu uaaaacugua uuguuucucg uuuuaauuua uuuuugcuug ccauucccca      240

cuugaaucgg gccgacggcu uggggagauu gcucuacuuc cccaaaucac uguggauuuu      300

ggaaaccagc agaaagagga aagagguagc aagagcucca gagagaaguc gaggaagaga      360

gagacggggu cagagagagc gcgcgggcgu gcgagcagcg aaagcgacag gggcaaagug      420

agugaccugc uuuugggggu gaccgccgga gcgcggcgug agcccucccc cuugggaucc      480

cgcagcugac cagucgcgcu gacggacaga cagacagaca ccgcccccag ccccagcuac      540

caccuccucc ccggccggcg gcggacagug gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg gguggagggg gucggggcuc gcggcgucgc acugaaacuu      660

uucguccaac uucugggcug uucucgcuuc ggaggagccg ugguccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagugcuagc ucgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc aguggcgacu cggcgcucgg      840

aagccgggcu cauggacggg ugaggcggcg gugugcgcag acagugcucc agccgcgcgc      900

gcuccccagg cccuggcccg ggccucgggc cggggaggaa gaguagcucg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggucgggccu ccgaaaccau gaacuuucug cugucuuggg ugcauuggag ccuugccuug     1080

cugcucuacc uccaccaugc caaguggucc caggcugcac ccauggcaga aggaggaggg     1140

cagaaucauc acgaaguggu gaaguucaug gaugucuauc agcgcagcua cugccaucca     1200

aucgagaccc ugguggacau cuuccaggag uacccugaug agaucgagua caucuucaag     1260

ccauccugug ugccccugau gcgaugcggg ggcugcugca augacgaggg ccuggagugu     1320

gugcccacug aggaguccaa caucaccaug cagauuaugc ggaucaaacc ucaccaaggc     1380

cagcacauag gagagaugag cuuccuacag cacaacaaau gugaaugcag accaaagaaa     1440

gauagagcaa gacaagaaaa ucccuguggg ccuugcucag agcggagaaa gcauuuguuu     1500

guacaagauc cgcagacgug uaaauguucc ugcaaaaaca cagacucgcg uugcaagaug     1560

ugacaagccg aggcggugag ccgggcagga ggaaggagcc ucccucaggg uuucgggaac     1620

cagaucucuc accaggaaag acugauacag aacgaucgau acagaaacca cgcugccgcc     1680

accacaccau caccaucgac agaacagucc uuaauccaga aaccugaaau gaaggaagag     1740

gagacucugc gcagagcacu uuggguccgg agggcgagac uccggcggaa gcauucccgg     1800

gcgggugacc cagcacgguc ccucuuggaa uuggauucgc cauuuuauuu uucuugcugc     1860

uaaaucaccg agcccggaag auuagagagu uuuauuucug ggauuccugu agacacaccc     1920

acccacauac auacauuuau auauauauau auuauauaua uauaaaaaua aauaucucua     1980

uuuuauauau auaaaauaua uauauucuuu uuuuaaauua acagugcuaa uguuauuggu     2040

gucuucacug gauguauuug acugcugugg acuugaguug ggaggggaau guucccacuc     2100

agauccugac agggaagagg aggagaugag agacucuggc augaucuuuu uuuuguccca     2160

cuuggugggg ccaggguccu cuccccugcc caggaaugug caaggccagg gcaugggggc     2220

aaauaugacc caguuuuggg aacaccgaca aacccagccc uggcgcugag ccucucuacc     2280

ccaggucaga cggacagaaa gacagaucac agguacaggg augaggacac cggcucugac     2340

caggaguuug gggagcuuca ggacauugcu gugcuuuggg gauucccucc acaugcugca     2400

cgcgcaucuc gcccccaggg gcacugccug gaagauucag gagccugggc ggccuucgcu     2460

uacucucacc ugcuucugag uugcccagga gaccacuggc agaugucccg gcgaagagaa     2520

gagacacauu guuggaagaa gcagcccaug acagcucccc uuccugggac ucgcccucau     2580

ccucuuccug cuccccuucc uggggugcag ccuaaaagga ccuauguccu cacaccauug     2640

aaaccacuag uucugucccc ccaggagacc ugguugugug ugugugagug guugaccuuc     2700

cuccaucccc ugguccuucc cuucccuucc cgaggcacag agagacaggg caggauccac     2760

gugcccauug uggaggcaga gaaaagagaa aguguuuuau auacgguacu uauuuaauau     2820

cccuuuuuaa uuagaaauua aaacaguuaa uuuaauuaaa gaguaggguu uuuuuucagu     2880

auucuugguu aauauuuaau uucaacuauu uaugagaugu aucuuuugcu cucucuugcu     2940

cucuuauuug uaccgguuuu uguauauaaa auucauguuu ccaaucucuc ucucccugau     3000

cggugacagu cacuagcuua ucuugaacag auauuuaauu uugcuaacac ucagcucugc     3060

ccuccccgau ccccuggcuc cccagcacac auuccuuuga aauaagguuu caauauacau     3120

cuacauacua uauauauauu uggcaacuug uauuugugug uauauauaua uauauauguu     3180

uauguauaua ugugauucug auaaaauaga cauugcuauu cuguuuuuua uauguaaaaa     3240

caaaacaaga aaaaauagag aauucuacau acuaaaucuc ucuccuuuuu uaauuuuaau     3300

auuuguuauc auuuauuuau uggugcuacu guuuauccgu aauaauugug gggaaaagau     3360

auuaacauca cgucuuuguc ucuagugcag uuuuucgaga uauuccguag uacauauuua     3420

uuuuuaaaca acgacaaaga aauacagaua uaucuuaaaa aaaaaaaagc auuuuguauu     3480

aaagaauuua auucugaucu caaaaaaaaa aaaaaaaaa                            3519


<210>  28
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Cys Asp Lys 
    130                 135                 140                 


Pro Arg Arg 
145         


<210>  29
<211>  3422
<212>  RNA
<213>  Homo sapiens

<400>  29
ucgcggaggc uuggggcagc cggguagcuc ggaggucgug gcgcuggggg cuagcaccag       60

cgcucugucg ggaggcgcag cgguuaggug gaccggucag cggacucacc ggccagggcg      120

cucggugcug gaauuugaua uucauugauc cggguuuuau cccucuucuu uuuucuuaaa      180

cauuuuuuuu uaaaacugua uuguuucucg uuuuaauuua uuuuugcuug ccauucccca      240

cuugaaucgg gccgacggcu uggggagauu gcucuacuuc cccaaaucac uguggauuuu      300

ggaaaccagc agaaagagga aagagguagc aagagcucca gagagaaguc gaggaagaga      360

gagacggggu cagagagagc gcgcgggcgu gcgagcagcg aaagcgacag gggcaaagug      420

agugaccugc uuuugggggu gaccgccgga gcgcggcgug agcccucccc cuugggaucc      480

cgcagcugac cagucgcgcu gacggacaga cagacagaca ccgcccccag ccccagcuac      540

caccuccucc ccggccggcg gcggacagug gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg gguggagggg gucggggcuc gcggcgucgc acugaaacuu      660

uucguccaac uucugggcug uucucgcuuc ggaggagccg ugguccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagugcuagc ucgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc aguggcgacu cggcgcucgg      840

aagccgggcu cauggacggg ugaggcggcg gugugcgcag acagugcucc agccgcgcgc      900

gcuccccagg cccuggcccg ggccucgggc cggggaggaa gaguagcucg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggucgggccu ccgaaaccau gaacuuucug cugucuuggg ugcauuggag ccuugccuug     1080

cugcucuacc uccaccaugc caaguggucc caggcugcac ccauggcaga aggaggaggg     1140

cagaaucauc acgaaguggu gaaguucaug gaugucuauc agcgcagcua cugccaucca     1200

aucgagaccc ugguggacau cuuccaggag uacccugaug agaucgagua caucuucaag     1260

ccauccugug ugccccugau gcgaugcggg ggcugcugca augacgaggg ccuggagugu     1320

gugcccacug aggaguccaa caucaccaug cagauuaugc ggaucaaacc ucaccaaggc     1380

cagcacauag gagagaugag cuuccuacag cacaacaaau gugaaugcag accaaagaaa     1440

gauagagcaa gacaagaaaa augugacaag ccgaggcggu gagccgggca ggaggaagga     1500

gccucccuca ggguuucggg aaccagaucu cucaccagga aagacugaua cagaacgauc     1560

gauacagaaa ccacgcugcc gccaccacac caucaccauc gacagaacag uccuuaaucc     1620

agaaaccuga aaugaaggaa gaggagacuc ugcgcagagc acuuuggguc cggagggcga     1680

gacuccggcg gaagcauucc cgggcgggug acccagcacg gucccucuug gaauuggauu     1740

cgccauuuua uuuuucuugc ugcuaaauca ccgagcccgg aagauuagag aguuuuauuu     1800

cugggauucc uguagacaca cccacccaca uacauacauu uauauauaua uauauuauau     1860

auauauaaaa auaaauaucu cuauuuuaua uauauaaaau auauauauuc uuuuuuuaaa     1920

uuaacagugc uaauguuauu ggugucuuca cuggauguau uugacugcug uggacuugag     1980

uugggagggg aauguuccca cucagauccu gacagggaag aggaggagau gagagacucu     2040

ggcaugaucu uuuuuuuguc ccacuuggug gggccagggu ccucuccccu gcccaggaau     2100

gugcaaggcc agggcauggg ggcaaauaug acccaguuuu gggaacaccg acaaacccag     2160

cccuggcgcu gagccucucu accccagguc agacggacag aaagacagau cacagguaca     2220

gggaugagga caccggcucu gaccaggagu uuggggagcu ucaggacauu gcugugcuuu     2280

ggggauuccc uccacaugcu gcacgcgcau cucgccccca ggggcacugc cuggaagauu     2340

caggagccug ggcggccuuc gcuuacucuc accugcuucu gaguugccca ggagaccacu     2400

ggcagauguc ccggcgaaga gaagagacac auuguuggaa gaagcagccc augacagcuc     2460

cccuuccugg gacucgcccu cauccucuuc cugcuccccu uccuggggug cagccuaaaa     2520

ggaccuaugu ccucacacca uugaaaccac uaguucuguc cccccaggag accugguugu     2580

guguguguga gugguugacc uuccuccauc cccugguccu ucccuucccu ucccgaggca     2640

cagagagaca gggcaggauc cacgugccca uuguggaggc agagaaaaga gaaaguguuu     2700

uauauacggu acuuauuuaa uaucccuuuu uaauuagaaa uuaaaacagu uaauuuaauu     2760

aaagaguagg guuuuuuuuc aguauucuug guuaauauuu aauuucaacu auuuaugaga     2820

uguaucuuuu gcucucucuu gcucucuuau uuguaccggu uuuuguauau aaaauucaug     2880

uuuccaaucu cucucucccu gaucggugac agucacuagc uuaucuugaa cagauauuua     2940

auuuugcuaa cacucagcuc ugcccucccc gauccccugg cuccccagca cacauuccuu     3000

ugaaauaagg uuucaauaua caucuacaua cuauauauau auuuggcaac uuguauuugu     3060

guguauauau auauauauau guuuauguau auaugugauu cugauaaaau agacauugcu     3120

auucuguuuu uuauauguaa aaacaaaaca agaaaaaaua gagaauucua cauacuaaau     3180

cucucuccuu uuuuaauuuu aauauuuguu aucauuuauu uauuggugcu acuguuuauc     3240

cguaauaauu guggggaaaa gauauuaaca ucacgucuuu gucucuagug caguuuuucg     3300

agauauuccg uaguacauau uuauuuuuaa acaacgacaa agaaauacag auauaucuua     3360

aaaaaaaaaa agcauuuugu auuaaagaau uuaauucuga ucucaaaaaa aaaaaaaaaa     3420

aa                                                                    3422


<210>  30
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Ser Leu Thr Arg Lys Asp 
            180                 185                 190     


<210>  31
<211>  3488
<212>  RNA
<213>  Homo sapiens

<400>  31
ucgcggaggc uuggggcagc cggguagcuc ggaggucgug gcgcuggggg cuagcaccag       60

cgcucugucg ggaggcgcag cgguuaggug gaccggucag cggacucacc ggccagggcg      120

cucggugcug gaauuugaua uucauugauc cggguuuuau cccucuucuu uuuucuuaaa      180

cauuuuuuuu uaaaacugua uuguuucucg uuuuaauuua uuuuugcuug ccauucccca      240

cuugaaucgg gccgacggcu uggggagauu gcucuacuuc cccaaaucac uguggauuuu      300

ggaaaccagc agaaagagga aagagguagc aagagcucca gagagaaguc gaggaagaga      360

gagacggggu cagagagagc gcgcgggcgu gcgagcagcg aaagcgacag gggcaaagug      420

agugaccugc uuuugggggu gaccgccgga gcgcggcgug agcccucccc cuugggaucc      480

cgcagcugac cagucgcgcu gacggacaga cagacagaca ccgcccccag ccccagcuac      540

caccuccucc ccggccggcg gcggacagug gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg gguggagggg gucggggcuc gcggcgucgc acugaaacuu      660

uucguccaac uucugggcug uucucgcuuc ggaggagccg ugguccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagugcuagc ucgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc aguggcgacu cggcgcucgg      840

aagccgggcu cauggacggg ugaggcggcg gugugcgcag acagugcucc agccgcgcgc      900

gcuccccagg cccuggcccg ggccucgggc cggggaggaa gaguagcucg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggucgggccu ccgaaaccau gaacuuucug cugucuuggg ugcauuggag ccuugccuug     1080

cugcucuacc uccaccaugc caaguggucc caggcugcac ccauggcaga aggaggaggg     1140

cagaaucauc acgaaguggu gaaguucaug gaugucuauc agcgcagcua cugccaucca     1200

aucgagaccc ugguggacau cuuccaggag uacccugaug agaucgagua caucuucaag     1260

ccauccugug ugccccugau gcgaugcggg ggcugcugca augacgaggg ccuggagugu     1320

gugcccacug aggaguccaa caucaccaug cagauuaugc ggaucaaacc ucaccaaggc     1380

cagcacauag gagagaugag cuuccuacag cacaacaaau gugaaugcag accaaagaaa     1440

gauagagcaa gacaagaaaa ucccuguggg ccuugcucag agcggagaaa gcauuuguuu     1500

guacaagauc cgcagacgug uaaauguucc ugcaaaaaca cagacucgcg uugcaaggcg     1560

aggcagcuug aguuaaacga acguacuugc agaucucuca ccaggaaaga cugauacaga     1620

acgaucgaua cagaaaccac gcugccgcca ccacaccauc accaucgaca gaacaguccu     1680

uaauccagaa accugaaaug aaggaagagg agacucugcg cagagcacuu uggguccgga     1740

gggcgagacu ccggcggaag cauucccggg cgggugaccc agcacggucc cucuuggaau     1800

uggauucgcc auuuuauuuu ucuugcugcu aaaucaccga gcccggaaga uuagagaguu     1860

uuauuucugg gauuccugua gacacaccca cccacauaca uacauuuaua uauauauaua     1920

uuauauauau auaaaaauaa auaucucuau uuuauauaua uaaaauauau auauucuuuu     1980

uuuaaauuaa cagugcuaau guuauuggug ucuucacugg auguauuuga cugcugugga     2040

cuugaguugg gaggggaaug uucccacuca gauccugaca gggaagagga ggagaugaga     2100

gacucuggca ugaucuuuuu uuugucccac uugguggggc caggguccuc uccccugccc     2160

aggaaugugc aaggccaggg caugggggca aauaugaccc aguuuuggga acaccgacaa     2220

acccagcccu ggcgcugagc cucucuaccc caggucagac ggacagaaag acagaucaca     2280

gguacaggga ugaggacacc ggcucugacc aggaguuugg ggagcuucag gacauugcug     2340

ugcuuugggg auucccucca caugcugcac gcgcaucucg cccccagggg cacugccugg     2400

aagauucagg agccugggcg gccuucgcuu acucucaccu gcuucugagu ugcccaggag     2460

accacuggca gaugucccgg cgaagagaag agacacauug uuggaagaag cagcccauga     2520

cagcuccccu uccugggacu cgcccucauc cucuuccugc uccccuuccu ggggugcagc     2580

cuaaaaggac cuauguccuc acaccauuga aaccacuagu ucuguccccc caggagaccu     2640

gguugugugu gugugagugg uugaccuucc uccauccccu gguccuuccc uucccuuccc     2700

gaggcacaga gagacagggc aggauccacg ugcccauugu ggaggcagag aaaagagaaa     2760

guguuuuaua uacgguacuu auuuaauauc ccuuuuuaau uagaaauuaa aacaguuaau     2820

uuaauuaaag aguaggguuu uuuuucagua uucuugguua auauuuaauu ucaacuauuu     2880

augagaugua ucuuuugcuc ucucuugcuc ucuuauuugu accgguuuuu guauauaaaa     2940

uucauguuuc caaucucucu cucccugauc ggugacaguc acuagcuuau cuugaacaga     3000

uauuuaauuu ugcuaacacu cagcucugcc cuccccgauc cccuggcucc ccagcacaca     3060

uuccuuugaa auaagguuuc aauauacauc uacauacuau auauauauuu ggcaacuugu     3120

auuugugugu auauauauau auauauguuu auguauauau gugauucuga uaaaauagac     3180

auugcuauuc uguuuuuuau auguaaaaac aaaacaagaa aaaauagaga auucuacaua     3240

cuaaaucucu cuccuuuuuu aauuuuaaua uuuguuauca uuuauuuauu ggugcuacug     3300

uuuauccgua auaauugugg ggaaaagaua uuaacaucac gucuuugucu cuagugcagu     3360

uuuucgagau auuccguagu acauauuuau uuuuaaacaa cgacaaagaa auacagauau     3420

aucuuaaaaa aaaaaaagca uuuuguauua aagaauuuaa uucugaucuc aaaaaaaaaa     3480

aaaaaaaa                                                              3488


<210>  32
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Cys Asp Lys Pro Arg Arg 
                165                 170     


<210>  33
<211>  3494
<212>  RNA
<213>  Homo sapiens

<400>  33
ucgcggaggc uuggggcagc cggguagcuc ggaggucgug gcgcuggggg cuagcaccag       60

cgcucugucg ggaggcgcag cgguuaggug gaccggucag cggacucacc ggccagggcg      120

cucggugcug gaauuugaua uucauugauc cggguuuuau cccucuucuu uuuucuuaaa      180

cauuuuuuuu uaaaacugua uuguuucucg uuuuaauuua uuuuugcuug ccauucccca      240

cuugaaucgg gccgacggcu uggggagauu gcucuacuuc cccaaaucac uguggauuuu      300

ggaaaccagc agaaagagga aagagguagc aagagcucca gagagaaguc gaggaagaga      360

gagacggggu cagagagagc gcgcgggcgu gcgagcagcg aaagcgacag gggcaaagug      420

agugaccugc uuuugggggu gaccgccgga gcgcggcgug agcccucccc cuugggaucc      480

cgcagcugac cagucgcgcu gacggacaga cagacagaca ccgcccccag ccccagcuac      540

caccuccucc ccggccggcg gcggacagug gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg gguggagggg gucggggcuc gcggcgucgc acugaaacuu      660

uucguccaac uucugggcug uucucgcuuc ggaggagccg ugguccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagugcuagc ucgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc aguggcgacu cggcgcucgg      840

aagccgggcu cauggacggg ugaggcggcg gugugcgcag acagugcucc agccgcgcgc      900

gcuccccagg cccuggcccg ggccucgggc cggggaggaa gaguagcucg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggucgggccu ccgaaaccau gaacuuucug cugucuuggg ugcauuggag ccuugccuug     1080

cugcucuacc uccaccaugc caaguggucc caggcugcac ccauggcaga aggaggaggg     1140

cagaaucauc acgaaguggu gaaguucaug gaugucuauc agcgcagcua cugccaucca     1200

aucgagaccc ugguggacau cuuccaggag uacccugaug agaucgagua caucuucaag     1260

ccauccugug ugccccugau gcgaugcggg ggcugcugca augacgaggg ccuggagugu     1320

gugcccacug aggaguccaa caucaccaug cagauuaugc ggaucaaacc ucaccaaggc     1380

cagcacauag gagagaugag cuuccuacag cacaacaaau gugaaugcag accaaagaaa     1440

gauagagcaa gacaagaaaa aaaaucaguu cgaggaaagg gaaaggggca aaaacgaaag     1500

cgcaagaaau cccgguauaa guccuggagc guaugugaca agccgaggcg gugagccggg     1560

caggaggaag gagccucccu caggguuucg ggaaccagau cucucaccag gaaagacuga     1620

uacagaacga ucgauacaga aaccacgcug ccgccaccac accaucacca ucgacagaac     1680

aguccuuaau ccagaaaccu gaaaugaagg aagaggagac ucugcgcaga gcacuuuggg     1740

uccggagggc gagacuccgg cggaagcauu cccgggcggg ugacccagca cggucccucu     1800

uggaauugga uucgccauuu uauuuuucuu gcugcuaaau caccgagccc ggaagauuag     1860

agaguuuuau uucugggauu ccuguagaca cacccaccca cauacauaca uuuauauaua     1920

uauauauuau auauauauaa aaauaaauau cucuauuuua uauauauaaa auauauauau     1980

ucuuuuuuua aauuaacagu gcuaauguua uuggugucuu cacuggaugu auuugacugc     2040

uguggacuug aguugggagg ggaauguucc cacucagauc cugacaggga agaggaggag     2100

augagagacu cuggcaugau cuuuuuuuug ucccacuugg uggggccagg guccucuccc     2160

cugcccagga augugcaagg ccagggcaug ggggcaaaua ugacccaguu uugggaacac     2220

cgacaaaccc agcccuggcg cugagccucu cuaccccagg ucagacggac agaaagacag     2280

aucacaggua cagggaugag gacaccggcu cugaccagga guuuggggag cuucaggaca     2340

uugcugugcu uuggggauuc ccuccacaug cugcacgcgc aucucgcccc caggggcacu     2400

gccuggaaga uucaggagcc ugggcggccu ucgcuuacuc ucaccugcuu cugaguugcc     2460

caggagacca cuggcagaug ucccggcgaa gagaagagac acauuguugg aagaagcagc     2520

ccaugacagc uccccuuccu gggacucgcc cucauccucu uccugcuccc cuuccugggg     2580

ugcagccuaa aaggaccuau guccucacac cauugaaacc acuaguucug uccccccagg     2640

agaccugguu gugugugugu gagugguuga ccuuccucca uccccugguc cuucccuucc     2700

cuucccgagg cacagagaga cagggcagga uccacgugcc cauuguggag gcagagaaaa     2760

gagaaagugu uuuauauacg guacuuauuu aauaucccuu uuuaauuaga aauuaaaaca     2820

guuaauuuaa uuaaagagua ggguuuuuuu ucaguauucu ugguuaauau uuaauuucaa     2880

cuauuuauga gauguaucuu uugcucucuc uugcucucuu auuuguaccg guuuuuguau     2940

auaaaauuca uguuuccaau cucucucucc cugaucggug acagucacua gcuuaucuug     3000

aacagauauu uaauuuugcu aacacucagc ucugcccucc ccgauccccu ggcuccccag     3060

cacacauucc uuugaaauaa gguuucaaua uacaucuaca uacuauauau auauuuggca     3120

acuuguauuu guguguauau auauauauau auguuuaugu auauauguga uucugauaaa     3180

auagacauug cuauucuguu uuuuauaugu aaaaacaaaa caagaaaaaa uagagaauuc     3240

uacauacuaa aucucucucc uuuuuuaauu uuaauauuug uuaucauuua uuuauuggug     3300

cuacuguuua uccguaauaa uuguggggaa aagauauuaa caucacgucu uugucucuag     3360

ugcaguuuuu cgagauauuc cguaguacau auuuauuuuu aaacaacgac aaagaaauac     3420

agauauaucu uaaaaaaaaa aaagcauuuu guauuaaaga auuuaauucu gaucucaaaa     3480

aaaaaaaaaa aaaa                                                       3494


<210>  34
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Cys Asp Lys Pro Arg Arg 
            340                 345                 350     


<210>  35
<211>  3477
<212>  RNA
<213>  Homo sapiens

<400>  35
gcggaggcuu ggggcagccg gguagcucgg aggucguggc gcugggggcu agcaccagcg       60

cucugucggg aggcgcagcg guuaggugga ccggucagcg gacucaccgg ccagggcgcu      120

cggugcugga auuugauauu cauugauccg gguuuuaucc cucuucuuuu uucuuaaaca      180

uuuuuuuuua aaacuguauu guuucucguu uuaauuuauu uuugcuugcc auuccccacu      240

ugaaucgggc cgacggcuug gggagauugc ucuacuuccc caaaucacug uggauuuugg      300

aaaccagcag aaagaggaaa gagguagcaa gagcuccaga gagaagucga ggaagagaga      360

gacgggguca gagagagcgc gcgggcgugc gagcagcgaa agcgacaggg gcaaagugag      420

ugaccugcuu uuggggguga ccgccggagc gcggcgugag cccucccccu ugggaucccg      480

cagcugacca gucgcgcuga cggacagaca gacagacacc gcccccagcc ccagcuacca      540

ccuccucccc ggccggcggc ggacagugga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg uggagggggu cggggcucgc ggcgucgcac ugaaacuuuu      660

cguccaacuu cugggcuguu cucgcuucgg aggagccgug guccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gugcuagcuc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag uggcgacucg gcgcucggaa      840

gccgggcuca uggacgggug aggcggcggu gugcgcagac agugcuccag ccgcgcgcgc      900

uccccaggcc cuggcccggg ccucgggccg gggaggaaga guagcucgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

ucgggccucc gaaaccauga acuuucugcu gucuugggug cauuggagcc uugccuugcu     1080

gcucuaccuc caccaugcca agugguccca ggcugcaccc auggcagaag gaggagggca     1140

gaaucaucac gaagugguga aguucaugga ugucuaucag cgcagcuacu gccauccaau     1200

cgagacccug guggacaucu uccaggagua cccugaugag aucgaguaca ucuucaagcc     1260

auccugugug ccccugaugc gaugcggggg cugcugcaau gacgagggcc uggagugugu     1320

gcccacugag gaguccaaca ucaccaugca gauuaugcgg aucaaaccuc accaaggcca     1380

gcacauagga gagaugagcu uccuacagca caacaaaugu gaaugcagac caaagaaaga     1440

uagagcaaga caagaaaaaa aaucaguucg aggaaaggga aaggggcaaa aacgaaagcg     1500

caagaaaucc cgguauaagu ccuggagcgu augugacaag ccgaggcggu gagccgggca     1560

ggaggaagga gccucccuca ggguuucggg aaccagaucu cucaccagga aagacugaua     1620

cagaacgauc gauacagaaa ccacgcugcc gccaccacac caucaccauc gacagaacag     1680

uccuuaaucc agaaaccuga aaugaaggaa gaggagacuc ugcgcagagc acuuuggguc     1740

cggagggcga gacuccggcg gaagcauucc cgggcgggug acccagcacg gucccucuug     1800

gaauuggauu cgccauuuua uuuuucuugc ugcuaaauca ccgagcccgg aagauuagag     1860

aguuuuauuu cugggauucc uguagacaca cccacccaca uacauacauu uauauauaua     1920

uauauuauau auauauaaaa auaaauaucu cuauuuuaua uauauaaaau auauauauuc     1980

uuuuuuuaaa uuaacagugc uaauguuauu ggugucuuca cuggauguau uugacugcug     2040

uggacuugag uugggagggg aauguuccca cucagauccu gacagggaag aggaggagau     2100

gagagacucu ggcaugaucu uuuuuuuguc ccacuuggug gggccagggu ccucuccccu     2160

gcccaggaau gugcaaggcc agggcauggg ggcaaauaug acccaguuuu gggaacaccg     2220

acaaacccag cccuggcgcu gagccucucu accccagguc agacggacag aaagacagau     2280

cacagguaca gggaugagga caccggcucu gaccaggagu uuggggagcu ucaggacauu     2340

gcugugcuuu ggggauuccc uccacaugcu gcacgcgcau cucgccccca ggggcacugc     2400

cuggaagauu caggagccug ggcggccuuc gcuuacucuc accugcuucu gaguugccca     2460

ggagaccacu ggcagauguc ccggcgaaga gaagagacac auuguuggaa gaagcagccc     2520

augacagcuc cccuuccugg gacucgcccu cauccucuuc cugcuccccu uccuggggug     2580

cagccuaaaa ggaccuaugu ccucacacca uugaaaccac uaguucuguc cccccaggag     2640

accugguugu guguguguga gugguugacc uuccuccauc cccugguccu ucccuucccu     2700

ucccgaggca cagagagaca gggcaggauc cacgugccca uuguggaggc agagaaaaga     2760

gaaaguguuu uauauacggu acuuauuuaa uaucccuuuu uaauuagaaa uuaaaacagu     2820

uaauuuaauu aaagaguagg guuuuuuuuc aguauucuug guuaauauuu aauuucaacu     2880

auuuaugaga uguaucuuuu gcucucucuu gcucucuuau uuguaccggu uuuuguauau     2940

aaaauucaug uuuccaaucu cucucucccu gaucggugac agucacuagc uuaucuugaa     3000

cagauauuua auuuugcuaa cacucagcuc ugcccucccc gauccccugg cuccccagca     3060

cacauuccuu ugaaauaagg uuucaauaua caucuacaua cuauauauau auuuggcaac     3120

uuguauuugu guguauauau auauauauau guuuauguau auaugugauu cugauaaaau     3180

agacauugcu auucuguuuu uuauauguaa aaacaaaaca agaaaaaaua gagaauucua     3240

cauacuaaau cucucuccuu uuuuaauuuu aauauuuguu aucauuuauu uauuggugcu     3300

acuguuuauc cguaauaauu guggggaaaa gauauuaaca ucacgucuuu gucucuagug     3360

caguuuuucg agauauuccg uaguacauau uuauuuuuaa acaacgacaa agaaauacag     3420

auauaucuua aaaaaaaaaa agcauuuugu auuaaagaau uuaauucuga ucucaaa        3477


<210>  36
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
1               5                   10                  15      


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
            20                  25                  30          


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
        35                  40                  45              


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
    50                  55                  60                  


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
65                  70                  75                  80  


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
                85                  90                  95      


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
            100                 105                 110         


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
        115                 120                 125             


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
    130                 135                 140                 


Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys 
145                 150                 155                 160 


Pro Arg Arg 
            


<210>  37
<211>  2569
<212>  RNA
<213>  Homo sapiens

<400>  37
gcggagccga uuacaucagc ccgggccugg ccggccgcgu guucccggag ccucggcugc       60

ccgaaugggg agcccagagu ggcgagcggc accccucccc ccgccagccc uccgcgggaa      120

ggugaccucu cgaguggucc caggcugcac ccauggcaga aggaggaggg cagaaucauc      180

acgaaguggu gaaguucaug gaugucuauc agcgcagcua cugccaucca aucgagaccc      240

ugguggacau cuuccaggag uacccugaug agaucgagua caucuucaag ccauccugug      300

ugccccugau gcgaugcggg ggcugcugca augacgaggg ccuggagugu gugcccacug      360

aggaguccaa caucaccaug cagauuaugc ggaucaaacc ucaccaaggc cagcacauag      420

gagagaugag cuuccuacag cacaacaaau gugaaugcag accaaagaaa gauagagcaa      480

gacaagaaaa ucccuguggg ccuugcucag agcggagaaa gcauuuguuu guacaagauc      540

cgcagacgug uaaauguucc ugcaaaaaca cagacucgcg uugcaaggcg aggcagcuug      600

aguuaaacga acguacuugc agaugugaca agccgaggcg gugagccggg caggaggaag      660

gagccucccu caggguuucg ggaaccagau cucucaccag gaaagacuga uacagaacga      720

ucgauacaga aaccacgcug ccgccaccac accaucacca ucgacagaac aguccuuaau      780

ccagaaaccu gaaaugaagg aagaggagac ucugcgcaga gcacuuuggg uccggagggc      840

gagacuccgg cggaagcauu cccgggcggg ugacccagca cggucccucu uggaauugga      900

uucgccauuu uauuuuucuu gcugcuaaau caccgagccc ggaagauuag agaguuuuau      960

uucugggauu ccuguagaca cacccaccca cauacauaca uuuauauaua uauauauuau     1020

auauauauaa aaauaaauau cucuauuuua uauauauaaa auauauauau ucuuuuuuua     1080

aauuaacagu gcuaauguua uuggugucuu cacuggaugu auuugacugc uguggacuug     1140

aguugggagg ggaauguucc cacucagauc cugacaggga agaggaggag augagagacu     1200

cuggcaugau cuuuuuuuug ucccacuugg uggggccagg guccucuccc cugcccagga     1260

augugcaagg ccagggcaug ggggcaaaua ugacccaguu uugggaacac cgacaaaccc     1320

agcccuggcg cugagccucu cuaccccagg ucagacggac agaaagacag aucacaggua     1380

cagggaugag gacaccggcu cugaccagga guuuggggag cuucaggaca uugcugugcu     1440

uuggggauuc ccuccacaug cugcacgcgc aucucgcccc caggggcacu gccuggaaga     1500

uucaggagcc ugggcggccu ucgcuuacuc ucaccugcuu cugaguugcc caggagacca     1560

cuggcagaug ucccggcgaa gagaagagac acauuguugg aagaagcagc ccaugacagc     1620

uccccuuccu gggacucgcc cucauccucu uccugcuccc cuuccugggg ugcagccuaa     1680

aaggaccuau guccucacac cauugaaacc acuaguucug uccccccagg agaccugguu     1740

gugugugugu gagugguuga ccuuccucca uccccugguc cuucccuucc cuucccgagg     1800

cacagagaga cagggcagga uccacgugcc cauuguggag gcagagaaaa gagaaagugu     1860

uuuauauacg guacuuauuu aauaucccuu uuuaauuaga aauuaaaaca guuaauuuaa     1920

uuaaagagua ggguuuuuuu ucaguauucu ugguuaauau uuaauuucaa cuauuuauga     1980

gauguaucuu uugcucucuc uugcucucuu auuuguaccg guuuuuguau auaaaauuca     2040

uguuuccaau cucucucucc cugaucggug acagucacua gcuuaucuug aacagauauu     2100

uaauuuugcu aacacucagc ucugcccucc ccgauccccu ggcuccccag cacacauucc     2160

uuugaaauaa gguuucaaua uacaucuaca uacuauauau auauuuggca acuuguauuu     2220

guguguauau auauauauau auguuuaugu auauauguga uucugauaaa auagacauug     2280

cuauucuguu uuuuauaugu aaaaacaaaa caagaaaaaa uagagaauuc uacauacuaa     2340

aucucucucc uuuuuuaauu uuaauauuug uuaucauuua uuuauuggug cuacuguuua     2400

uccguaauaa uuguggggaa aagauauuaa caucacgucu uugucucuag ugcaguuuuu     2460

cgagauauuc cguaguacau auuuauuuuu aaacaacgac aaagaaauac agauauaucu     2520

uaaaaaaaaa aaagcauuuu guauuaaaga auuuaauucu gaucucaaa                 2569


<210>  38
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg Ser 
            180                 185                 190         


Ala Gly Gln Glu Glu Gly Ala Ser Leu Arg Val Ser Gly Thr Arg Ser 
        195                 200                 205             


Leu Thr Arg Lys Asp 
    210             


<210>  39
<211>  3554
<212>  RNA
<213>  Homo sapiens

<400>  39
ucgcggaggc uuggggcagc cggguagcuc ggaggucgug gcgcuggggg cuagcaccag       60

cgcucugucg ggaggcgcag cgguuaggug gaccggucag cggacucacc ggccagggcg      120

cucggugcug gaauuugaua uucauugauc cggguuuuau cccucuucuu uuuucuuaaa      180

cauuuuuuuu uaaaacugua uuguuucucg uuuuaauuua uuuuugcuug ccauucccca      240

cuugaaucgg gccgacggcu uggggagauu gcucuacuuc cccaaaucac uguggauuuu      300

ggaaaccagc agaaagagga aagagguagc aagagcucca gagagaaguc gaggaagaga      360

gagacggggu cagagagagc gcgcgggcgu gcgagcagcg aaagcgacag gggcaaagug      420

agugaccugc uuuugggggu gaccgccgga gcgcggcgug agcccucccc cuugggaucc      480

cgcagcugac cagucgcgcu gacggacaga cagacagaca ccgcccccag ccccagcuac      540

caccuccucc ccggccggcg gcggacagug gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg gguggagggg gucggggcuc gcggcgucgc acugaaacuu      660

uucguccaac uucugggcug uucucgcuuc ggaggagccg ugguccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagugcuagc ucgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc aguggcgacu cggcgcucgg      840

aagccgggcu cauggacggg ugaggcggcg gugugcgcag acagugcucc agccgcgcgc      900

gcuccccagg cccuggcccg ggccucgggc cggggaggaa gaguagcucg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggucgggccu ccgaaaccau gaacuuucug cugucuuggg ugcauuggag ccuugccuug     1080

cugcucuacc uccaccaugc caaguggucc caggcugcac ccauggcaga aggaggaggg     1140

cagaaucauc acgaaguggu gaaguucaug gaugucuauc agcgcagcua cugccaucca     1200

aucgagaccc ugguggacau cuuccaggag uacccugaug agaucgagua caucuucaag     1260

ccauccugug ugccccugau gcgaugcggg ggcugcugca augacgaggg ccuggagugu     1320

gugcccacug aggaguccaa caucaccaug cagauuaugc ggaucaaacc ucaccaaggc     1380

cagcacauag gagagaugag cuuccuacag cacaacaaau gugaaugcag accaaagaaa     1440

gauagagcaa gacaagaaaa ucccuguggg ccuugcucag agcggagaaa gcauuuguuu     1500

guacaagauc cgcagacgug uaaauguucc ugcaaaaaca cagacucgcg uugcaaggcg     1560

aggcagcuug aguuaaacga acguacuugc agaugugaca agccgaggcg gugagccggg     1620

caggaggaag gagccucccu caggguuucg ggaaccagau cucucaccag gaaagacuga     1680

uacagaacga ucgauacaga aaccacgcug ccgccaccac accaucacca ucgacagaac     1740

aguccuuaau ccagaaaccu gaaaugaagg aagaggagac ucugcgcaga gcacuuuggg     1800

uccggagggc gagacuccgg cggaagcauu cccgggcggg ugacccagca cggucccucu     1860

uggaauugga uucgccauuu uauuuuucuu gcugcuaaau caccgagccc ggaagauuag     1920

agaguuuuau uucugggauu ccuguagaca cacccaccca cauacauaca uuuauauaua     1980

uauauauuau auauauauaa aaauaaauau cucuauuuua uauauauaaa auauauauau     2040

ucuuuuuuua aauuaacagu gcuaauguua uuggugucuu cacuggaugu auuugacugc     2100

uguggacuug aguugggagg ggaauguucc cacucagauc cugacaggga agaggaggag     2160

augagagacu cuggcaugau cuuuuuuuug ucccacuugg uggggccagg guccucuccc     2220

cugcccagga augugcaagg ccagggcaug ggggcaaaua ugacccaguu uugggaacac     2280

cgacaaaccc agcccuggcg cugagccucu cuaccccagg ucagacggac agaaagacag     2340

aucacaggua cagggaugag gacaccggcu cugaccagga guuuggggag cuucaggaca     2400

uugcugugcu uuggggauuc ccuccacaug cugcacgcgc aucucgcccc caggggcacu     2460

gccuggaaga uucaggagcc ugggcggccu ucgcuuacuc ucaccugcuu cugaguugcc     2520

caggagacca cuggcagaug ucccggcgaa gagaagagac acauuguugg aagaagcagc     2580

ccaugacagc uccccuuccu gggacucgcc cucauccucu uccugcuccc cuuccugggg     2640

ugcagccuaa aaggaccuau guccucacac cauugaaacc acuaguucug uccccccagg     2700

agaccugguu gugugugugu gagugguuga ccuuccucca uccccugguc cuucccuucc     2760

cuucccgagg cacagagaga cagggcagga uccacgugcc cauuguggag gcagagaaaa     2820

gagaaagugu uuuauauacg guacuuauuu aauaucccuu uuuaauuaga aauuaaaaca     2880

guuaauuuaa uuaaagagua ggguuuuuuu ucaguauucu ugguuaauau uuaauuucaa     2940

cuauuuauga gauguaucuu uugcucucuc uugcucucuu auuuguaccg guuuuuguau     3000

auaaaauuca uguuuccaau cucucucucc cugaucggug acagucacua gcuuaucuug     3060

aacagauauu uaauuuugcu aacacucagc ucugcccucc ccgauccccu ggcuccccag     3120

cacacauucc uuugaaauaa gguuucaaua uacaucuaca uacuauauau auauuuggca     3180

acuuguauuu guguguauau auauauauau auguuuaugu auauauguga uucugauaaa     3240

auagacauug cuauucuguu uuuuauaugu aaaaacaaaa caagaaaaaa uagagaauuc     3300

uacauacuaa aucucucucc uuuuuuaauu uuaauauuug uuaucauuua uuuauuggug     3360

cuacuguuua uccguaauaa uuguggggaa aagauauuaa caucacgucu uugucucuag     3420

ugcaguuuuu cgagauauuc cguaguacau auuuauuuuu aaacaacgac aaagaaauac     3480

agauauaucu uaaaaaaaaa aaagcauuuu guauuaaaga auuuaauucu gaucucaaaa     3540

aaaaaaaaaa aaaa                                                       3554


<210>  40
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Pro Leu Leu Arg Arg Leu Leu Leu Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Ala Pro Ala Gln Ala Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln 
            20                  25                  30          


Arg Lys Val Val Ser Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln 
        35                  40                  45              


Pro Arg Glu Val Val Val Pro Leu Thr Val Glu Leu Met Gly Thr Val 
    50                  55                  60                  


Ala Lys Gln Leu Val Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly 
65                  70                  75                  80  


Cys Cys Pro Asp Asp Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln 
                85                  90                  95      


Val Arg Met Gln Ile Leu Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly 
            100                 105                 110         


Glu Met Ser Leu Glu Glu His Ser Gln Cys Glu Cys Arg Pro Lys Lys 
        115                 120                 125             


Lys Asp Ser Ala Val Lys Pro Asp Ser Pro Arg Pro Leu Cys Pro Arg 
    130                 135                 140                 


Cys Thr Gln His His Gln Arg Pro Asp Pro Arg Thr Cys Arg Cys Arg 
145                 150                 155                 160 


Cys Arg Arg Arg Ser Phe Leu Arg Cys Gln Gly Arg Gly Leu Glu Leu 
                165                 170                 175     


Asn Pro Asp Thr Cys Arg Cys Arg Lys Leu Arg Arg 
            180                 185             


<210>  41
<211>  1704
<212>  RNA
<213>  Homo sapiens

<400>  41
gccguccccg ccgccgcugc ccgccgccac cggccgcccg cccgcccggc uccuccggcc       60

gccuccgcug cgcugcgcug cgcugccugc acccagggcu cgggaggggg ccgcggagga      120

gucgcccccc gcgcccggcc cccgcccgcc gcgcccgggc ccgcgccaug gggcucuggc      180

ugucgccgcc ccccgcgccg ccgggcuagg gcgaugcggg cgcccccggc gggcggcccc      240

ggcgggcacc augagcccuc ugcuccgccg ccugcugcuc gccgcacucc ugcagcuggc      300

ccccgcccag gccccugucu cccagccuga ugccccuggc caccagagga aagugguguc      360

auggauagau guguauacuc gcgcuaccug ccagccccgg gagguggugg ugcccuugac      420

uguggagcuc augggcaccg uggccaaaca gcuggugccc agcugcguga cugugcagcg      480

cugugguggc ugcugcccug acgauggccu ggagugugug cccacugggc agcaccaagu      540

ccggaugcag auccucauga uccgguaccc gagcagucag cugggggaga ugucccugga      600

agaacacagc cagugugaau gcagaccuaa aaaaaaggac agugcuguga agccagacag      660

ccccaggccc cucugcccac gcugcaccca gcaccaccag cgcccugacc cccggaccug      720

ccgcugccgc ugccgacgcc gcagcuuccu ccguugccaa gggcggggcu uagagcucaa      780

cccagacacc ugcaggugcc ggaagcugcg aaggugacac auggcuuuuc agacucagca      840

gggugacuug ccucagaggc uauaucccag ugggggaaca aagaggagcc ugguaaaaaa      900

cagccaagcc cccaagaccu cagcccaggc agaagcugcu cuaggaccug ggccucucag      960

agggcucuuc ugccaucccu ugucucccug aggccaucau caaacaggac agaguuggaa     1020

gaggagacug ggaggcagca agagggguca cauaccagcu caggggagaa uggaguacug     1080

ucucaguuuc uaaccacucu gugcaaguaa gcaucuuaca acuggcucuu ccuccccuca     1140

cuaagaagac ccaaaccucu gcauaauggg auuugggcuu ugguacaaga acugugaccc     1200

ccaacccuga uaaaagagau ggaaggagcu gucccugccu gugucacugu uugucacugu     1260

ccaggcuggc ugguuugggc augaaugucu gcaucacuaa auccagagcu ugucuugcuc     1320

ccucauugug cagauggagg aaaugaggac uaaggcccca cagcagaucc caggcagggc     1380

cagaauuaug uauucaucac uuucaaguua uugccacgca ugggagucag ggauagccca     1440

gucaauacag acugccugcc cuccugcucu ucaccagggu ucuuuucuag aaggagacag     1500

ccuucugugg ccagagagcu ugggguagga cccagaucua cugagugacc uugcuuguca     1560

cuaccccugc cucucugagc agcaguuucc acaugugcac auagagggaa cagaagauug     1620

cugugguugg cguccucggg ccccagagaa guuugagacu aucuuuacgu aauagaaaag     1680

aacacuuguu cuuccugcca ggca                                            1704


<210>  42
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Pro Leu Leu Arg Arg Leu Leu Leu Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Ala Pro Ala Gln Ala Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln 
            20                  25                  30          


Arg Lys Val Val Ser Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln 
        35                  40                  45              


Pro Arg Glu Val Val Val Pro Leu Thr Val Glu Leu Met Gly Thr Val 
    50                  55                  60                  


Ala Lys Gln Leu Val Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly 
65                  70                  75                  80  


Cys Cys Pro Asp Asp Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln 
                85                  90                  95      


Val Arg Met Gln Ile Leu Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly 
            100                 105                 110         


Glu Met Ser Leu Glu Glu His Ser Gln Cys Glu Cys Arg Pro Lys Lys 
        115                 120                 125             


Lys Asp Ser Ala Val Lys Pro Asp Arg Ala Ala Thr Pro His His Arg 
    130                 135                 140                 


Pro Gln Pro Arg Ser Val Pro Gly Trp Asp Ser Ala Pro Gly Ala Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Ile Thr His Pro Thr Pro Ala Pro Gly Pro Ser Ala 
                165                 170                 175     


His Ala Ala Pro Ser Thr Thr Ser Ala Leu Thr Pro Gly Pro Ala Ala 
            180                 185                 190         


Ala Ala Ala Asp Ala Ala Ala Ser Ser Val Ala Lys Gly Gly Ala 
        195                 200                 205         


<210>  43
<211>  1805
<212>  RNA
<213>  Homo sapiens

<400>  43
gccguccccg ccgccgcugc ccgccgccac cggccgcccg cccgcccggc uccuccggcc       60

gccuccgcug cgcugcgcug cgcugccugc acccagggcu cgggaggggg ccgcggagga      120

gucgcccccc gcgcccggcc cccgcccgcc gcgcccgggc ccgcgccaug gggcucuggc      180

ugucgccgcc ccccgcgccg ccgggcuagg gcgaugcggg cgcccccggc gggcggcccc      240

ggcgggcacc augagcccuc ugcuccgccg ccugcugcuc gccgcacucc ugcagcuggc      300

ccccgcccag gccccugucu cccagccuga ugccccuggc caccagagga aagugguguc      360

auggauagau guguauacuc gcgcuaccug ccagccccgg gagguggugg ugcccuugac      420

uguggagcuc augggcaccg uggccaaaca gcuggugccc agcugcguga cugugcagcg      480

cugugguggc ugcugcccug acgauggccu ggagugugug cccacugggc agcaccaagu      540

ccggaugcag auccucauga uccgguaccc gagcagucag cugggggaga ugucccugga      600

agaacacagc cagugugaau gcagaccuaa aaaaaaggac agugcuguga agccagacag      660

ggcugccacu ccccaccacc guccccagcc ccguucuguu ccgggcuggg acucugcccc      720

cggagcaccc uccccagcug acaucaccca ucccacucca gccccaggcc ccucugccca      780

cgcugcaccc agcaccacca gcgcccugac ccccggaccu gccgcugccg cugccgacgc      840

cgcagcuucc uccguugcca agggcggggc uuagagcuca acccagacac cugcaggugc      900

cggaagcugc gaaggugaca cauggcuuuu cagacucagc agggugacuu gccucagagg      960

cuauauccca gugggggaac aaagaggagc cugguaaaaa acagccaagc ccccaagacc     1020

ucagcccagg cagaagcugc ucuaggaccu gggccucuca gagggcucuu cugccauccc     1080

uugucucccu gaggccauca ucaaacagga cagaguugga agaggagacu gggaggcagc     1140

aagagggguc acauaccagc ucaggggaga auggaguacu gucucaguuu cuaaccacuc     1200

ugugcaagua agcaucuuac aacuggcucu uccuccccuc acuaagaaga cccaaaccuc     1260

ugcauaaugg gauuugggcu uugguacaag aacugugacc cccaacccug auaaaagaga     1320

uggaaggagc ugucccugcc ugugucacug uuugucacug uccaggcugg cugguuuggg     1380

caugaauguc ugcaucacua aauccagagc uugucuugcu cccucauugu gcagauggag     1440

gaaaugagga cuaaggcccc acagcagauc ccaggcaggg ccagaauuau guauucauca     1500

cuuucaaguu auugccacgc augggaguca gggauagccc agucaauaca gacugccugc     1560

ccuccugcuc uucaccaggg uucuuuucua gaaggagaca gccuucugug gccagagagc     1620

uugggguagg acccagaucu acugagugac cuugcuuguc acuaccccug ccucucugag     1680

cagcaguuuc cacaugugca cauagaggga acagaagauu gcugugguug gcguccucgg     1740

gccccagaga aguuugagac uaucuuuacg uaauagaaaa gaacacuugu ucuuccugcc     1800

aggca                                                                 1805


<210>  44
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  44

Met His Leu Leu Gly Phe Phe Ser Val Ala Cys Ser Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Leu Pro Gly Pro Arg Glu Ala Pro Ala Ala Ala Ala Ala Phe 
            20                  25                  30          


Glu Ser Gly Leu Asp Leu Ser Asp Ala Glu Pro Asp Ala Gly Glu Ala 
        35                  40                  45              


Thr Ala Tyr Ala Ser Lys Asp Leu Glu Glu Gln Leu Arg Ser Val Ser 
    50                  55                  60                  


Ser Val Asp Glu Leu Met Thr Val Leu Tyr Pro Glu Tyr Trp Lys Met 
65                  70                  75                  80  


Tyr Lys Cys Gln Leu Arg Lys Gly Gly Trp Gln His Asn Arg Glu Gln 
                85                  90                  95      


Ala Asn Leu Asn Ser Arg Thr Glu Glu Thr Ile Lys Phe Ala Ala Ala 
            100                 105                 110         


His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg Lys 
        115                 120                 125             


Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu Phe 
    130                 135                 140                 


Gly Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val Tyr 
145                 150                 155                 160 


Arg Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn Thr 
                165                 170                 175     


Ser Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro Leu 
            180                 185                 190         


Ser Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr Ser 
        195                 200                 205             


Cys Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser Ile 
    210                 215                 220                 


Ile Arg Arg Ser Leu Pro Ala Thr Leu Pro Gln Cys Gln Ala Ala Asn 
225                 230                 235                 240 


Lys Thr Cys Pro Thr Asn Tyr Met Trp Asn Asn His Ile Cys Arg Cys 
                245                 250                 255     


Leu Ala Gln Glu Asp Phe Met Phe Ser Ser Asp Ala Gly Asp Asp Ser 
            260                 265                 270         


Thr Asp Gly Phe His Asp Ile Cys Gly Pro Asn Lys Glu Leu Asp Glu 
        275                 280                 285             


Glu Thr Cys Gln Cys Val Cys Arg Ala Gly Leu Arg Pro Ala Ser Cys 
    290                 295                 300                 


Gly Pro His Lys Glu Leu Asp Arg Asn Ser Cys Gln Cys Val Cys Lys 
305                 310                 315                 320 


Asn Lys Leu Phe Pro Ser Gln Cys Gly Ala Asn Arg Glu Phe Asp Glu 
                325                 330                 335     


Asn Thr Cys Gln Cys Val Cys Lys Arg Thr Cys Pro Arg Asn Gln Pro 
            340                 345                 350         


Leu Asn Pro Gly Lys Cys Ala Cys Glu Cys Thr Glu Ser Pro Gln Lys 
        355                 360                 365             


Cys Leu Leu Lys Gly Lys Lys Phe His His Gln Thr Cys Ser Cys Tyr 
    370                 375                 380                 


Arg Arg Pro Cys Thr Asn Arg Gln Lys Ala Cys Glu Pro Gly Phe Ser 
385                 390                 395                 400 


Tyr Ser Glu Glu Val Cys Arg Cys Val Pro Ser Tyr Trp Lys Arg Pro 
                405                 410                 415     


Gln Met Ser 
            


<210>  45
<211>  2259
<212>  RNA
<213>  Homo sapiens

<400>  45
augcccugcc ccugcgcccg ccgccgccgc cgccgccgcu cagcccggcg cgcucuggag       60

gauccugcgc cgcggcgcuc ccgggccccg ccgccgccag ccgccccgcc gcccuccucc      120

cgcccccggc accgccgcca gcgcccccgc cgcagcgccc gcggcccggc uccucucacu      180

ucggggaagg ggagggagga gggggacgag ggcucuggcg gguuuggagg ggcugaacau      240

cgcggggugu ucuggugucc cccgccccgc cucuccaaaa agcuacaccg acgcggaccg      300

cggcggcguc cucccucgcc cucgcuucac cucgcgggcu ccgaaugcgg ggagcucgga      360

uguccgguuu ccugugaggc uuuuaccuga cacccgccgc cuuuccccgg cacuggcugg      420

gagggcgccc ugcaaaguug ggaacgcgga gccccggacc cgcucccgcc gccuccggcu      480

cgcccagggg gggucgccgg gaggagcccg ggggagaggg accaggaggg gcccgcggcc      540

ucgcaggggc gcccgcgccc ccaccccugc ccccgccagc ggaccggucc cccacccccg      600

guccuuccac caugcacuug cugggcuucu ucucuguggc guguucucug cucgccgcug      660

cgcugcuccc ggguccucgc gaggcgcccg ccgccgccgc cgccuucgag uccggacucg      720

accucucgga cgcggagccc gacgcgggcg aggccacggc uuaugcaagc aaagaucugg      780

aggagcaguu acggucugug uccaguguag augaacucau gacuguacuc uacccagaau      840

auuggaaaau guacaagugu cagcuaagga aaggaggcug gcaacauaac agagaacagg      900

ccaaccucaa cucaaggaca gaagagacua uaaaauuugc ugcagcacau uauaauacag      960

agaucuugaa aaguauugau aaugagugga gaaagacuca augcaugcca cgggaggugu     1020

guauagaugu ggggaaggag uuuggagucg cgacaaacac cuucuuuaaa ccuccaugug     1080

uguccgucua cagauguggg gguugcugca auagugaggg gcugcagugc augaacacca     1140

gcacgagcua ccucagcaag acguuauuug aaauuacagu gccucucucu caaggcccca     1200

aaccaguaac aaucaguuuu gccaaucaca cuuccugccg augcaugucu aaacuggaug     1260

uuuacagaca aguucauucc auuauuagac guucccugcc agcaacacua ccacaguguc     1320

aggcagcgaa caagaccugc cccaccaauu acauguggaa uaaucacauc ugcagaugcc     1380

uggcucagga agauuuuaug uuuuccucgg augcuggaga ugacucaaca gauggauucc     1440

augacaucug uggaccaaac aaggagcugg augaagagac cugucagugu gucugcagag     1500

cggggcuucg gccugccagc uguggacccc acaaagaacu agacagaaac ucaugccagu     1560

gugucuguaa aaacaaacuc uuccccagcc aauguggggc caaccgagaa uuugaugaaa     1620

acacaugcca guguguaugu aaaagaaccu gccccagaaa ucaaccccua aauccuggaa     1680

aaugugccug ugaauguaca gaaaguccac agaaaugcuu guuaaaagga aagaaguucc     1740

accaccaaac augcagcugu uacagacggc cauguacgaa ccgccagaag gcuugugagc     1800

caggauuuuc auauagugaa gaaguguguc guuguguccc uucauauugg aaaagaccac     1860

aaaugagcua agauuguacu guuuuccagu ucaucgauuu ucuauuaugg aaaacugugu     1920

ugccacagua gaacugucug ugaacagaga gacccuugug gguccaugcu aacaaagaca     1980

aaagucuguc uuuccugaac cauguggaua acuuuacaga aauggacugg agcucaucug     2040

caaaaggccu cuuguaaaga cugguuuucu gccaaugacc aaacagccaa gauuuuccuc     2100

uugugauuuc uuuaaaagaa ugacuauaua auuuauuucc acuaaaaaua uuguuucugc     2160

auucauuuuu auagcaacaa caauugguaa aacucacugu gaucaauauu uuuauaucau     2220

gcaaaauaug uuuaaaauaa aaugaaaauu guauuauaa                            2259


<210>  46
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Tyr Arg Glu Trp Val Val Val Asn Val Phe Met Met Leu Tyr Val 
1               5                   10                  15      


Gln Leu Val Gln Gly Ser Ser Asn Glu His Gly Pro Val Lys Arg Ser 
            20                  25                  30          


Ser Gln Ser Thr Leu Glu Arg Ser Glu Gln Gln Ile Arg Ala Ala Ser 
        35                  40                  45              


Ser Leu Glu Glu Leu Leu Arg Ile Thr His Ser Glu Asp Trp Lys Leu 
    50                  55                  60                  


Trp Arg Cys Arg Leu Arg Leu Lys Ser Phe Thr Ser Met Asp Ser Arg 
65                  70                  75                  80  


Ser Ala Ser His Arg Ser Thr Arg Phe Ala Ala Thr Phe Tyr Asp Ile 
                85                  90                  95      


Glu Thr Leu Lys Val Ile Asp Glu Glu Trp Gln Arg Thr Gln Cys Ser 
            100                 105                 110         


Pro Arg Glu Thr Cys Val Glu Val Ala Ser Glu Leu Gly Lys Ser Thr 
        115                 120                 125             


Asn Thr Phe Phe Lys Pro Pro Cys Val Asn Val Phe Arg Cys Gly Gly 
    130                 135                 140                 


Cys Cys Asn Glu Glu Ser Leu Ile Cys Met Asn Thr Ser Thr Ser Tyr 
145                 150                 155                 160 


Ile Ser Lys Gln Leu Phe Glu Ile Ser Val Pro Leu Thr Ser Val Pro 
                165                 170                 175     


Glu Leu Val Pro Val Lys Val Ala Asn His Thr Gly Cys Lys Cys Leu 
            180                 185                 190         


Pro Thr Ala Pro Arg His Pro Tyr Ser Ile Ile Arg Arg Ser Ile Gln 
        195                 200                 205             


Ile Pro Glu Glu Asp Arg Cys Ser His Ser Lys Lys Leu Cys Pro Ile 
    210                 215                 220                 


Asp Met Leu Trp Asp Ser Asn Lys Cys Lys Cys Val Leu Gln Glu Glu 
225                 230                 235                 240 


Asn Pro Leu Ala Gly Thr Glu Asp His Ser His Leu Gln Glu Pro Ala 
                245                 250                 255     


Leu Cys Gly Pro His Met Met Phe Asp Glu Asp Arg Cys Glu Cys Val 
            260                 265                 270         


Cys Lys Thr Pro Cys Pro Lys Asp Leu Ile Gln His Pro Lys Asn Cys 
        275                 280                 285             


Ser Cys Phe Glu Cys Lys Glu Ser Leu Glu Thr Cys Cys Gln Lys His 
    290                 295                 300                 


Lys Leu Phe His Pro Asp Thr Cys Ser Cys Glu Asp Arg Cys Pro Phe 
305                 310                 315                 320 


His Thr Arg Pro Cys Ala Ser Gly Lys Thr Ala Cys Ala Lys His Cys 
                325                 330                 335     


Arg Phe Pro Lys Glu Lys Arg Ala Ala Gln Gly Pro His Ser Arg Lys 
            340                 345                 350         


Asn Pro 
        


<210>  47
<211>  2069
<212>  RNA
<213>  Homo sapiens

<400>  47
aagacacaug cuucugcaag cuuccaugaa gguugugcaa aaaaguuuca auccagaguu       60

ggguuccagc uuucuguagc uguaagcauu gguggccaca ccaccuccuu acaaagcaac      120

uagaaccugc ggcauacauu ggagagauuu uuuuaauuuu cuggacauga aguaaauuua      180

gagugcuuuc uaauuucagg uagaagacau guccaccuuc ugauuauuuu uggagaacau      240

uuugauuuuu uucaucucuc ucuccccacc ccuaagauug ugcaaaaaaa gcguaccuug      300

ccuaauugaa auaauuucau uggauuuuga ucagaacuga uuauuugguu uucuguguga      360

aguuuugagg uuucaaacuu uccuucugga gaaugccuuu ugaaacaauu uucucuagcu      420

gccugauguc aacugcuuag uaaucagugg auauugaaau auucaaaaug uacagagagu      480

ggguaguggu gaauguuuuc augauguugu acguccagcu ggugcagggc uccaguaaug      540

aacauggacc agugaagcga ucaucucagu ccacauugga acgaucugaa cagcagauca      600

gggcugcuuc uaguuuggag gaacuacuuc gaauuacuca cucugaggac uggaagcugu      660

ggagaugcag gcugaggcuc aaaaguuuua ccaguaugga cucucgcuca gcaucccauc      720

gguccacuag guuugcggca acuuucuaug acauugaaac acuaaaaguu auagaugaag      780

aauggcaaag aacucagugc agcccuagag aaacgugcgu ggagguggcc agugagcugg      840

ggaagaguac caacacauuc uucaagcccc cuugugugaa cguguuccga ugugguggcu      900

guugcaauga agagagccuu aucuguauga acaccagcac cucguacauu uccaaacagc      960

ucuuugagau aucagugccu uugacaucag uaccugaauu agugccuguu aaaguugcca     1020

aucauacagg uuguaagugc uugccaacag ccccccgcca uccauacuca auuaucagaa     1080

gauccaucca gaucccugaa gaagaucgcu guucccauuc caagaaacuc uguccuauug     1140

acaugcuaug ggauagcaac aaauguaaau guguuuugca ggaggaaaau ccacuugcug     1200

gaacagaaga ccacucucau cuccaggaac cagcucucug ugggccacac augauguuug     1260

acgaagaucg uugcgagugu gucuguaaaa caccaugucc caaagaucua auccagcacc     1320

ccaaaaacug caguugcuuu gagugcaaag aaagucugga gaccugcugc cagaagcaca     1380

agcuauuuca cccagacacc ugcagcugug aggacagaug ccccuuucau accagaccau     1440

gugcaagugg caaaacagca ugugcaaagc auugccgcuu uccaaaggag aaaagggcug     1500

cccaggggcc ccacagccga aagaauccuu gauucagcgu uccaaguucc ccaucccugu     1560

cauuuuuaac agcaugcugc uuugccaagu ugcugucacu guuuuuuucc cagguguuaa     1620

aaaaaaaauc cauuuuacac agcaccacag ugaauccaga ccaaccuucc auucacacca     1680

gcuaaggagu cccugguuca uugauggaug ucuucuagcu gcagaugccu cugcgcacca     1740

aggaauggag aggaggggac ccauguaauc cuuuuguuua guuuuguuuu uguuuuuugg     1800

ugaaugagaa aggugugcug gucauggaau ggcagguguc auaugacuga uuacucagag     1860

cagaugagga aaacuguagu cucugagucc uuugcuaauc gcaacucuug ugaauuauuc     1920

ugauucuuuu uuaugcagaa uuugauucgu augaucagua cugacuuucu gauuacuguc     1980

cagcuuauag ucuuccaguu uaaugaacua ccaucugaug uuucauauuu aaguguauuu     2040

aaagaaaaua aacaccauua uucaagcca                                       2069


