                         SEQUENCE LISTING

<110>  Medicago Inc.
 
<120>  Modified Viral Structural Protein

<130>  V815385WO

<150>  US 63/073,327
<151>  2020-09-01

<150>  US 63/211,716
<151>  2021-06-17

<160>  173   

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  SARS-CoV-2

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  1258
<212>  PRT
<213>  SARS-CoV-2

<400>  2

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1190                 1195                 1200             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1205                 1210                 1215             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1220                 1225                 1230             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1235                 1240                 1245             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1250                 1255             


<210>  3
<211>  568
<212>  PRT
<213>  Influenza

<400>  3

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Thr Asn Asp Leu Cys Tyr Pro Gly Ser Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Leu Gly Ser Pro Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Lys Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Ile Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Ser Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Ile Arg Asn Gly Thr Tyr Asn Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
        515                 520                 525             


Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
    530                 535                 540                 


Leu Ala Ile Met Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg Ile Cys Ile 
                565             


<210>  4
<211>  1729
<212>  DNA
<213>  Influenza

<400>  4
ctgtaaaaat ggagaaaata gtgcttcttc ttgcaatagt cagtcttgtt aaaagtgatc       60

agatttgcat tggttaccat gcaaacaatt caacagagca ggttgacaca atcatggaaa      120

agaacgttac tgttacacat gcccaagaca tactggaaaa gacacacaac gggaagctct      180

gcgatctaga tggagtgaag cctctaattt taagagattg tagtgtagct ggatggctcc      240

tcgggaaccc aatgtgtgac gaattcatca atgtaccgga atggtcttac atagtggaga      300

aggccaatcc aaccaatgac ctctgttacc cagggagttt caacgactat gaagaactga      360

aacacctatt gagcagaata aaccattttg agaaaattca aatcatcccc aaaagttctt      420

ggtccgatca tgaagcctca tcaggagtga gctcagcatg tccatacctg ggaagtccct      480

ccttttttag aaatgtggta tggcttatca aaaagaacag tacataccca acaataaaga      540

aaagctacaa taataccaac caagaagatc ttttggtact gtggggaatt caccatccta      600

atgatgcggc agagcagaca aggctatatc aaaacccaac cacctatatt tccattggga      660

catcaacact aaaccagaga ttggtaccaa aaatagctac tagatccaaa gtaaacgggc      720

aaagtggaag gatggagttc ttctggacaa ttttaaaacc taatgatgca atcaacttcg      780

agagtaatgg aaatttcatt gctccagaat atgcatacaa aattgtcaag aaaggggact      840

cagcaattat gaaaagtgaa ttggaatatg gtaactgcaa caccaagtgt caaactccaa      900

tgggggcgat aaactctagt atgccattcc acaacataca ccctctcacc atcggggaat      960

gccccaaata tgtgaaatca aacagattag tccttgcaac agggctcaga aatagccctc     1020

aaagagagag cagaagaaaa aagagaggac tatttggagc tatagcaggt tttatagagg     1080

gaggatggca gggaatggta gatggttggt atgggtacca ccatagcaat gagcagggga     1140

gtgggtacgc tgcagacaaa gaatccactc aaaaggcaat agatggagtc accaataagg     1200

tcaactcaat cattgacaaa atgaacactc agtttgaggc cgttggaagg gaatttaata     1260

acttagaaag gagaatagag aatttaaaca agaagatgga agacgggttt ctagatgtct     1320

ggacttataa tgccgaactt ctggttctca tggaaaatga gagaactcta gactttcatg     1380

actcaaatgt taagaacctc tacgacaagg tccgactaca gcttagggat aatgcaaagg     1440

agctgggtaa cggttgtttc gagttctatc acaaatgtga taatgaatgt atggaaagta     1500

taagaaacgg aacgtacaac tatccgcagt attcagaaga agcaagatta aaaagagagg     1560

aaataagtgg ggtaaaattg gaatcaatag gaacttacca aatactgtca atttattcaa     1620

cagtggcgag ttccctagca ctggcaatca tgatggctgg tctatcttta tggatgtgct     1680

ccaatggatc gttacaatgc agaatttgca tttaaatttg tgagttcag                 1729


<210>  5
<211>  1250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified SARS-CoV-2 with H5 A/Indonesia/5/05 Hemagglutinin CT AA

<400>  5

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Ser  Leu Trp Met Cys Ser  Asn Gly Ser Leu Gln  Cys Arg Ile 
    1235                 1240                 1245             


Cys Ile  
    1250 


<210>  6
<211>  50
<212>  PRT
<213>  Influenza

<400>  6

Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr Gln Ile Leu Ala 
1               5                   10                  15      


Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val Val Ser Leu Gly 
            20                  25                  30          


Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
        35                  40                  45              


Cys Ile 
    50  


<210>  7
<211>  50
<212>  PRT
<213>  Influenza

<400>  7

Ile Lys Gly Val Lys Leu Ser Ser Met Gly Val Tyr Gln Ile Leu Ala 
1               5                   10                  15      


Ile Tyr Ala Thr Val Ala Gly Ser Leu Ser Leu Ala Ile Met Met Ala 
            20                  25                  30          


Gly Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
        35                  40                  45              


Cys Ile 
    50  


<210>  8
<211>  49
<212>  PRT
<213>  Influenza

<400>  8

Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp 
1               5                   10                  15      


Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly 
            20                  25                  30          


Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys 
        35                  40                  45              


Ile 
    


<210>  9
<211>  50
<212>  PRT
<213>  Influenza

<400>  9

Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser 
1               5                   10                  15      


Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met Met Ala 
            20                  25                  30          


Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
        35                  40                  45              


Cys Ile 
    50  


<210>  10
<211>  50
<212>  PRT
<213>  Influenza

<400>  10

Ile Glu Ser Val Lys Leu Glu Asn Leu Gly Val Tyr Gln Ile Leu Ala 
1               5                   10                  15      


Ile Tyr Ser Thr Val Ser Ser Ser Leu Val Leu Val Gly Leu Ile Met 
            20                  25                  30          


Ala Met Gly Leu Trp Met Cys Ser Asn Gly Ser Met Gln Cys Arg Ile 
        35                  40                  45              


Cys Ile 
    50  


<210>  11
<211>  49
<212>  PRT
<213>  Influenza

<400>  11

Ile Asp Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp 
1               5                   10                  15      


Phe Ser Phe Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly 
            20                  25                  30          


Leu Val Phe Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys 
        35                  40                  45              


Ile 
    


<210>  12
<211>  50
<212>  PRT
<213>  Influenza

<400>  12

Ile Glu Gly Val Lys Leu Glu Ser Glu Gly Thr Tyr Lys Ile Leu Thr 
1               5                   10                  15      


Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Ala Met Gly Phe Ala 
            20                  25                  30          


Ala Phe Leu Phe Trp Ala Met Ser Asn Gly Ser Cys Arg Cys Asn Ile 
        35                  40                  45              


Cys Ile 
    50  


<210>  13
<211>  50
<212>  PRT
<213>  Influenza

<400>  13

Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu 
1               5                   10                  15      


Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala 
            20                  25                  30          


Ile Phe Val Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile 
        35                  40                  45              


Cys Leu 
    50  


<210>  14
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence of C-Terminal Region of Influenza 
       Hemagglutinin


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Ile Xaa Gly Val Lys Leu Xaa Ser Xaa Gly Xaa Tyr Xaa Ile Leu Xaa 
1               5                   10                  15      


Ile Tyr Ser Thr Val Ala Ser Ser Leu Xaa Leu Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Trp Met Cys Ser Asn Gly Ser Xaa Xaa Cys Xaa Ile 
        35                  40                  45              


Cys Ile 
    50  


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence of CT Domain of Influenza Hemagglutinin


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Xaa Xaa Trp Met Cys Ser Asn Gly Ser Xaa Xaa Cys Xaa Ile Cys Ile 
1               5                   10                  15      


<210>  16
<211>  69
<212>  PRT
<213>  SARS-CoV-2

<400>  16

Trp Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe 
1               5                   10                  15      


Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met Leu Cys Cys 
            20                  25                  30          


Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly Ser 
        35                  40                  45              


Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys Gly Val 
    50                  55                  60                  


Lys Leu His Tyr Thr 
65                  


<210>  17
<211>  50
<212>  PRT
<213>  Influenza

<400>  17

Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser 
1               5                   10                  15      


Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met Met Ala 
            20                  25                  30          


Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
        35                  40                  45              


Cys Ile 
    50  


<210>  18
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-Terminal Region of Modified SARS-CoV-2 S protein with H5i 
       Hemagglutinin CT

<400>  18

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln 
            20                  25                  30          


Cys Arg Ile Cys Ile 
        35          


<210>  19
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-Terminal Region of Modified SARS-CoV-2 S protein with H5i 
       Hemagglutinin CT, Variation 1

<400>  19

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
            20                  25                  30          


Ser Leu Gln Cys Arg Ile Cys Ile 
        35                  40  


<210>  20
<211>  1258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (no SP) SARS-CoV-2 S protein GSAS+PP wtTM/CT AA

<400>  20

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1190                 1195                 1200             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1205                 1210                 1215             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1220                 1225                 1230             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1235                 1240                 1245             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1250                 1255             


<210>  21
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (no SP) Modified SARS-CoV-2 S protein GSAS+PP with H5i 
       Hemagglutinin CT AA

<400>  21

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1190                 1195                 1200             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1205                 1210                 1215             


Leu Ser  Leu Trp Met Cys Ser  Asn Gly Ser Leu Gln  Cys Arg Ile 
    1220                 1225                 1230             


Cys Ile  
    1235 


<210>  22
<211>  3849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-CoV-2 S protein GSAS+PP wtTM/CT-DNA

<400>  22
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctct gctgcatgac ctcttgctgc tcctgtctga aaggctgctg ctcttgcgga     3780

tcctgctgca aatttgatga ggatgacagt gaaccagtcc tgaagggcgt gaagctgcac     3840

tatacttag                                                             3849


<210>  23
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-CoV-2 S protein GSAS+PP wtTM/CT-AA

<400>  23

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Met Thr Ser 
    1235                 1240                 1245             


Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser Cys Gly  Ser Cys Cys 
    1250                 1255                 1260             


Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val Leu Lys  Gly Val Lys 
    1265                 1270                 1275             


Leu His  Tyr Thr 
    1280         


<210>  24
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(PDI)-CoV(opt2).c

<400>  24
tctcagatct tcgcggtgaa tcttacgacg cgaacacagt taccacccgc at               52


<210>  25
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(AVB)-CoV(opt2).r

<400>  25
acgacacgac taaggcctct aagtatagtg cagcttcacg cccttcagga c                51


<210>  26
<211>  3789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-Modified SARS-CoV-2 S protein GSAS+PP H5iTM/CT-DNA

<400>  26
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atcaaatact gtcaatttat tcaacagtgg cgagttccct agcactggca     3720

atcatgatgg ctggtctatc tttatggatg tgctccaatg gatcgttaca atgcagaatt     3780

tgcatttaa                                                             3789


<210>  27
<211>  1262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-Modified SARS-CoV-2 S protein GSAS+PP H5iTM/CT-AA

<400>  27

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Gln  Ile Leu Ser Ile Tyr  Ser Thr Val 
    1220                 1225                 1230             


Ala Ser  Ser Leu Ala Leu Ala  Ile Met Met Ala Gly  Leu Ser Leu 
    1235                 1240                 1245             


Trp Met  Cys Ser Asn Gly Ser  Leu Gln Cys Arg Ile  Cys Ile 
    1250                 1255                 1260         


<210>  28
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(Avb)-H5I.r

<400>  28
acgacacgac taaggccttt aaatgcaaat tctgcattgt aacgatcc                    48


<210>  29
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-Modified SARS-CoV-2 S protein GSAS+PP wtTM/H5iCT-DNA

<400>  29
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctct ctttatggat gtgctccaat ggatcgttac aatgcagaat ttgcatttaa     3780


<210>  30
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-Modified SARS-CoV-2 S protein GSAS+PP wtTM/H5iCT-AA

<400>  30

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Ser Leu  Trp Met Cys 
    1235                 1240                 1245             


Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys Ile 
    1250                 1255                 


<210>  31
<211>  4474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cloning vector 8501 from left to right T-DNA

<400>  31
tggcaggata tattgtggtg taaacaaatt gacgcttaga caacttaata acacattgcg       60

gacgttttta atgtactgaa ttaacgccga atcccgggct ggtatattta tatgttgtca      120

aataactcaa aaaccataaa agtttaagtt agcaagtgtg tacattttta cttgaacaaa      180

aatattcacc tactactgtt ataaatcatt attaaacatt agagtaaaga aatatggatg      240

ataagaacaa gagtagtgat attttgacaa caattttgtt gcaacatttg agaaaatttt      300

gttgttctct cttttcattg gtcaaaaaca atagagagag aaaaaggaag agggagaata      360

aaaacataat gtgagtatga gagagaaagt tgtacaaaag ttgtaccaaa atagttgtac      420

aaatatcatt gaggaatttg acaaaagcta cacaaataag ggttaattgc tgtaaataaa      480

taaggatgac gcattagaga gatgtaccat tagagaattt ttggcaagtc attaaaaaga      540

aagaataaat tatttttaaa attaaaagtt gagtcatttg attaaacatg tgattattta      600

atgaattgat gaaagagttg gattaaagtt gtattagtaa ttagaatttg gtgtcaaatt      660

taatttgaca tttgatcttt tcctatatat tgccccatag agtcagttaa ctcattttta      720

tatttcatag atcaaataag agaaataacg gtatattaat ccctccaaaa aaaaaaaacg      780

gtatatttac taaaaaatct aagccacgta ggaggataac aggatccccg taggaggata      840

acatccaatc caaccaatca caacaatcct gatgagataa cccactttaa gcccacgcat      900

ctgtggcaca tctacattat ctaaatcaca cattcttcca cacatctgag ccacacaaaa      960

accaatccac atctttatca cccattctat aaaaaatcac actttgtgag tctacacttt     1020

gattcccttc aaacacatac aaagagaaga gactaattaa ttaattaatc atcttgagag     1080

aaaatggaac gagctataca aggaaacgac gctagggaac aagctaacag tgaacgttgg     1140

gatggaggat caggaggtac cacttctccc ttcaaacttc ctgacgaaag tccgagttgg     1200

actgagtggc ggctacataa cgatgagacg aattcgaatc aagataatcc ccttggtttc     1260

aaggaaagct ggggtttcgg gaaagttgta tttaagagat atctcagata cgacaggacg     1320

gaagcttcac tgcacagagt ccttggatct tggacgggag attcggttaa ctatgcagca     1380

tctcgatttt tcggtttcga ccagatcgga tgtacctata gtattcggtt tcgaggagtt     1440

agtatcaccg tttctggagg gtcgcgaact cttcagcatc tctgtgagat ggcaattcgg     1500

tctaagcaag aactgctaca gcttgcccca atcgaagtgg aaagtaatgt atcaagagga     1560

tgccctgaag gtactcaaac cttcgaaaaa gaaagcgagt aagttaaaat gcttcttcgt     1620

ctcctattta taatatggtt tgttattgtt aattttgttc ttgtagaaga gcttaattaa     1680

tcgttgttgt tatgaaatac tatttgtatg agatgaactg gtgtaatgta attcatttac     1740

ataagtggag tcagaatcag aatgtttcct ccataactaa ctagacatga agacctgccg     1800

cgtacaattg tcttatattt gaacaactaa aattgaacat cttttgccac aactttataa     1860

gtggttaata tagctcaaat atatggtcaa gttcaataga ttaataatgg aaatatcagt     1920

tatcgaaatt cattaacaat caacttaacg ttattaacta ctaattttat atcatcccct     1980

ttgataaatg atagtacacc aattaggaag gagcatgctc gcctaggaga ttgtcgtttc     2040

ccgccttcag tttgcaagct gctctagccg tgtagccaat acgcaaaccg cctctccccg     2100

cgcgttggga attactagcg cgtgtcgaca agcttgcatg ccggtcaaca tggtggagca     2160

cgacacactt gtctactcca aaaatatcaa agatacagtc tcagaagacc aaagggcaat     2220

tgagactttt caacaaaggg taatatccgg aaacctcctc ggattccatt gcccagctat     2280

ctgtcacttt attgtgaaga tagtggaaaa ggaaggtggc tcctacaaat gccatcattg     2340

cgataaagga aaggccatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc     2400

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt     2460

ggattgatgt gataacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga     2520

tacagtctca gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa     2580

cctcctcgga ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga     2640

aggtggctcc tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc     2700

tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga     2760

cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg acgtaaggga     2820

tgacgcacaa tcccactatc cttcgcaaga cccttcctct atataaggaa gttcatttca     2880

tttggagagg cacacaattt gctttagtga ttaaactttc ttttacaaca aattaaaggt     2940

ctattatctc ccaacaacat aagaaaacaa tggcgaaaaa cgttgcgatt ttcggcttat     3000

tgttttctct tcttgtgttg gttccttctc agatcttcgc gacgtcactc ctcagccaaa     3060

acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg     3120

gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt gacctggaac     3180

tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc tgacctctac     3240

actctgagca gctcagtgac tgtcccctcc agcacctggc ccagcgagac cgtcacctgc     3300

aacgttgccc acccggccag cagcaccaag gtggacaaga aaattgtgcc cagggattgt     3360

ggttgtaagc cttgcatatg tacagtccca gaagtatcat ctgtcttcat cttcccccca     3420

aagcccaagg atgtgctcac cattactctg actcctaagg tcacgtgtgt tgtggtagac     3480

atcagcaagg atgatcccga ggtccagttc agctggtttg tagatgatgt ggaggtgcac     3540

acagctcaga cgcaaccccg ggaggagcag ttcaacagca ctttccgctc agtcagtgaa     3600

cttcccatca tgcaccagga ctggctcaat ggcaaggaga cgtccagatt ttggcgatct     3660

attcaactgt cgccagttca ttggtactgg tagtctccct gggggcaatc agtttctgga     3720

tgtgctctaa tgggtctcta cagtgtagaa tatgtattta aaggccttag tcgtgtcgtt     3780

tttcaaataa tataatcctt ttagggtttt agttagttta aattttctgt tgctcctgtt     3840

tagcaggtcg tgccttcagc aagcacacaa aaacagagtg tttattttaa gttgtttgtt     3900

tagtgattca aaaaaaaaat cgttcaaaca tttggcaata aagtttctta agattgaatc     3960

ctgttgccgg tcttgcgatg attatcatat aatttctgtt gaattacgtt aagcatgtaa     4020

taattaacat gtaatgcatg acgttattta tgagatgggt ttttatgatt agagtcccgc     4080

aattatacat ttaatacgcg atagaaaaca aaatatagcg cgcaaactag gataaattat     4140

cgcgcgcggt gtcatctatg ttactagatc tctagagtct caagcttggc gcgcccacgt     4200

gactagtggc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc     4260

aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc     4320

gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgctag agcagcttga     4380

gcttggatca gattgtcgtt tcccgccttc agtttaaact atcagtgttt gacaggatat     4440

attggcgggt aaacctaaga gaaaagagcg ttta                                 4474


<210>  32
<211>  5083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 8586 from 2X35S prom to NOS term

<400>  32
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggcac acaatttgct ttagtgatta aactttcttt      780

tacaacaaat taaaggtcta ttatctccca acaacataag aaaacaatgg cgaaaaacgt      840

tgcgattttc ggcttattgt tttctcttct tgtgttggtt ccttctcaga tcttcgcggt      900

gaatcttacg acgcgaacac agttaccacc cgcatataca aatagcttca ctcggggtgt      960

ttattacccc gacaaagtgt tcaggtcctc cgtgctccac tcaacacagg acctctttct     1020

tcctttcttt tctaacgtga catggtttca tgccattcat gtatccggca ctaacggtac     1080

taagaggttc gataatcctg tgctcccttt caatgacggc gtttactttg caagcacaga     1140

gaagagtaac atcatccgag gttggatctt tggcactacc ctcgattcaa agacgcagag     1200

cctcctcatt gtgaacaatg ccactaacgt ggtgatcaaa gtttgcgagt ttcagttctg     1260

caatgaccct ttcttggggg tgtactatca taagaacaac aagtcttgga tggaatctga     1320

attccgcgtc tatagcagcg ccaacaactg cacctttgaa tacgtgtccc agcccttcct     1380

tatggacctg gagggaaagc agggaaactt taagaatctg agagagttcg tgtttaaaaa     1440

tatcgacggc tattttaaga tctattctaa gcacacgcct attaatctcg tgcgcgatct     1500

tccacaaggc ttcagcgccc tggaaccact cgtggacctc ccaattggta tcaacatcac     1560

tagatttcag actctgcttg ccctccaccg atcctatctg acacccggag actcctctag     1620

cggctggact gccggcgctg ccgcttatta cgttggttat cttcagccac gcacgttcct     1680

gctgaagtat aacgagaatg gtactattac cgatgccgtg gattgtgccc ttgaccccct     1740

gtccgaaact aagtgcacac tcaagtcatt cactgtggaa aaaggaatct accagacaag     1800

caattttcgg gtccagccta ctgagagcat tgtgcgcttt cctaacatca caaatctttg     1860

ccccttcgga gaggttttca atgctacacg gtttgcctcc gtgtatgcct ggaaccgcaa     1920

gagaatttcc aattgcgtgg ccgattactc cgtgctctac aatagtgcaa gctttagcac     1980

ctttaagtgc tatggcgtat cccctactaa gcttaacgac ttgtgtttca caaacgtgta     2040

tgccgactcc tttgtgatac ggggcgacga agttagacag atagcaccag gacagacggg     2100

aaagatagct gactacaact ataagcttcc tgatgacttc actggctgcg ttatcgcgtg     2160

gaattctaac aacctggact caaaagtcgg cggcaactat aactatctct atcggctgtt     2220

ccgcaagagt aaccttaagc cctttgagag agatataagc actgaaatct accaggctgg     2280

cagtacgccc tgtaatggcg tggaaggctt taattgttat tttccactgc aatcctatgg     2340

ttttcagcca accaatggcg tgggctacca accataccgc gtcgtggtgc tctcctttga     2400

actgctccac gctcccgcga ctgtctgcgg ccccaagaag tccacgaacc ttgtgaagaa     2460

taagtgcgtt aattttaatt tcaacggcct cactggaaca ggagtgctca ctgagagtaa     2520

caagaagttc ctgccatttc aacaatttgg cagagacata gccgatacta ctgacgccgt     2580

tagggacccc cagaccctcg agattctcga tataacgccc tgctccttcg gtggagtttc     2640

cgtgatcacg ccaggcacca ataccagtaa ccaggtcgcc gtgctgtatc aggatgtcaa     2700

ctgtactgag gtgcccgtag ccatccatgc ggatcagctc acaccaactt ggagggtgta     2760

cagcaccggc tccaatgtat tccagactcg ggccggatgc cttattggcg ccgaacacgt     2820

gaacaatagt tacgaatgcg atattccaat tggcgccgga atctgtgcta gctaccagac     2880

tcagacgaac tccccaggca gcgccagcag cgttgccagc cagtcaatca tcgcttatac     2940

aatgtcactt ggagccgaaa actccgtggc ttactcaaac aacagcatcg ccatccccac     3000

aaacttcacc atatccgtga caactgagat tctgccagtg tccatgacta agacgtccgt     3060

agattgcact atgtacatat gcggcgacag cacagaatgt tctaatctgc tgctgcaata     3120

tggaagcttc tgcactcaac tgaacagagc gctcacaggc atcgccgtgg agcaggataa     3180

gaatacccag gaggtgttcg cccaagttaa gcagatctac aagaccccac ccataaagga     3240

tttcggtgga ttcaatttta gtcagatact cccagaccca tctaagccat ccaagaggag     3300

ctttatcgag gatcttttgt ttaacaaagt tactctggcc gacgccggtt tcatcaagca     3360

gtacggagat tgcctcggcg acatcgctgc tcgtgacctc atctgtgcgc aaaagtttaa     3420

cggtctgacg gtgctgcctc ccctccttac tgatgaaatg atcgcccagt ataccagcgc     3480

actcctcgct ggcaccataa catccggttg gacattcggc gctggtgcag cactgcagat     3540

accattcgcc atgcaaatgg catatcgttt caacggtatc ggtgtcacac agaatgtcct     3600

atatgagaac cagaagctga tcgcaaatca gttcaatagt gccatcggaa aaatccagga     3660

tagccttagc agcacagcct cagcccttgg caaactccag gatgtcgtga accagaatgc     3720

ccaggctctc aataccctcg tgaagcagct ctcatctaat ttcggcgcaa tttccagtgt     3780

cctcaacgac atcctcagcc gcctcgaccc ccccgaggcc gaagtgcaga ttgacagact     3840

gattacaggt cgactccaga gcctccagac ttacgtgact cagcagctga taagagccgc     3900

cgagataagg gccagcgcta acctggctgc cacaaagatg tctgagtgcg tgctgggcca     3960

gtccaagaga gtagacttct gtggcaaagg ctaccatctg atgagcttcc cacaatccgc     4020

acctcacggc gtagtgttcc tccacgtgac atatgtaccg gctcaggaga agaatttcac     4080

taccgctcct gctatatgcc atgatggaaa ggctcacttc ccccgggagg gggtgttcgt     4140

gtccaacggc acccattggt ttgtgactca gcggaatttc tacgaacccc agatcataac     4200

cactgacaac acatttgtgt ccggaaattg tgacgtggtc attggaatag tgaacaacac     4260

tgtttatgat ccactgcagc cagaacttga cagctttaag gaggagctcg acaagtactt     4320

caagaatcat acgtcaccag atgtggacct cggagatatt agcggtatca atgccagtgt     4380

tgtcaatatt cagaaggaaa tagaccgcct taatgaggtc gccaaaaatc tgaacgagag     4440

cctcatcgat cttcaggagc tgggcaaata tgagcagtac atcaagtggc cttggtatat     4500

ttggcttggc ttcatcgccg gcctgatcgc catagtaatg gtcacaatta tgctctgctg     4560

catgacctct tgctgctcct gtctgaaagg ctgctgctct tgcggatcct gctgcaaatt     4620

tgatgaggat gacagtgaac cagtcctgaa gggcgtgaag ctgcactata cttagaggcc     4680

ttagtcgtgt cgtttttcaa ataatataat ccttttaggg ttttagttag tttaaatttt     4740

ctgttgctcc tgtttagcag gtcgtgcctt cagcaagcac acaaaaacag agtgtttatt     4800

ttaagttgtt tgtttagtga ttcaaaaaaa aaatcgttca aacatttggc aataaagttt     4860

cttaagattg aatcctgttg ccggtcttgc gatgattatc atataatttc tgttgaatta     4920

cgttaagcat gtaataatta acatgtaatg catgacgtta tttatgagat gggtttttat     4980

gattagagtc ccgcaattat acatttaata cgcgatagaa aacaaaatat agcgcgcaaa     5040

ctaggataaa ttatcgcgcg cggtgtcatc tatgttacta gat                       5083


<210>  33
<211>  4461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cloning vector 8500 from left to right T-DNA

<400>  33
tggcaggata tattgtggtg taaacaaatt gacgcttaga caacttaata acacattgcg       60

gacgttttta atgtactgaa ttaacgccga atcccgggct ggtatattta tatgttgtca      120

aataactcaa aaaccataaa agtttaagtt agcaagtgtg tacattttta cttgaacaaa      180

aatattcacc tactactgtt ataaatcatt attaaacatt agagtaaaga aatatggatg      240

ataagaacaa gagtagtgat attttgacaa caattttgtt gcaacatttg agaaaatttt      300

gttgttctct cttttcattg gtcaaaaaca atagagagag aaaaaggaag agggagaata      360

aaaacataat gtgagtatga gagagaaagt tgtacaaaag ttgtaccaaa atagttgtac      420

aaatatcatt gaggaatttg acaaaagcta cacaaataag ggttaattgc tgtaaataaa      480

taaggatgac gcattagaga gatgtaccat tagagaattt ttggcaagtc attaaaaaga      540

aagaataaat tatttttaaa attaaaagtt gagtcatttg attaaacatg tgattattta      600

atgaattgat gaaagagttg gattaaagtt gtattagtaa ttagaatttg gtgtcaaatt      660

taatttgaca tttgatcttt tcctatatat tgccccatag agtcagttaa ctcattttta      720

tatttcatag atcaaataag agaaataacg gtatattaat ccctccaaaa aaaaaaaacg      780

gtatatttac taaaaaatct aagccacgta ggaggataac aggatccccg taggaggata      840

acatccaatc caaccaatca caacaatcct gatgagataa cccactttaa gcccacgcat      900

ctgtggcaca tctacattat ctaaatcaca cattcttcca cacatctgag ccacacaaaa      960

accaatccac atctttatca cccattctat aaaaaatcac actttgtgag tctacacttt     1020

gattcccttc aaacacatac aaagagaaga gactaattaa ttaattaatc atcttgagag     1080

aaaatggaac gagctataca aggaaacgac gctagggaac aagctaacag tgaacgttgg     1140

gatggaggat caggaggtac cacttctccc ttcaaacttc ctgacgaaag tccgagttgg     1200

actgagtggc ggctacataa cgatgagacg aattcgaatc aagataatcc ccttggtttc     1260

aaggaaagct ggggtttcgg gaaagttgta tttaagagat atctcagata cgacaggacg     1320

gaagcttcac tgcacagagt ccttggatct tggacgggag attcggttaa ctatgcagca     1380

tctcgatttt tcggtttcga ccagatcgga tgtacctata gtattcggtt tcgaggagtt     1440

agtatcaccg tttctggagg gtcgcgaact cttcagcatc tctgtgagat ggcaattcgg     1500

tctaagcaag aactgctaca gcttgcccca atcgaagtgg aaagtaatgt atcaagagga     1560

tgccctgaag gtactcaaac cttcgaaaaa gaaagcgagt aagttaaaat gcttcttcgt     1620

ctcctattta taatatggtt tgttattgtt aattttgttc ttgtagaaga gcttaattaa     1680

tcgttgttgt tatgaaatac tatttgtatg agatgaactg gtgtaatgta attcatttac     1740

ataagtggag tcagaatcag aatgtttcct ccataactaa ctagacatga agacctgccg     1800

cgtacaattg tcttatattt gaacaactaa aattgaacat cttttgccac aactttataa     1860

gtggttaata tagctcaaat atatggtcaa gttcaataga ttaataatgg aaatatcagt     1920

tatcgaaatt cattaacaat caacttaacg ttattaacta ctaattttat atcatcccct     1980

ttgataaatg atagtacacc aattaggaag gagcatgctc gcctaggaga ttgtcgtttc     2040

ccgccttcag tttgcaagct gctctagccg tgtagccaat acgcaaaccg cctctccccg     2100

cgcgttggga attactagcg cgtgtcgaca agcttgcatg ccggtcaaca tggtggagca     2160

cgacacactt gtctactcca aaaatatcaa agatacagtc tcagaagacc aaagggcaat     2220

tgagactttt caacaaaggg taatatccgg aaacctcctc ggattccatt gcccagctat     2280

ctgtcacttt attgtgaaga tagtggaaaa ggaaggtggc tcctacaaat gccatcattg     2340

cgataaagga aaggccatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc     2400

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt     2460

ggattgatgt gataacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga     2520

tacagtctca gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa     2580

cctcctcgga ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga     2640

aggtggctcc tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc     2700

tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga     2760

cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg acgtaaggga     2820

tgacgcacaa tcccactatc cttcgcaaga cccttcctct atataaggaa gttcatttca     2880

tttggagagg cacttttcta atcaatcatc aaacagaacg cagaaaattt cctaaaaaca     2940

aaaaaaaggc atacaaatgg cgaaaaacgt tgcgattttc ggcttattgt tttctcttct     3000

tgtgttggtt ccttctcaga tcttcgcgac gtcactcctc agccaaaacg acacccccat     3060

ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg accctgggat     3120

gcctggtcaa gggctatttc cctgagccag tgacagtgac ctggaactct ggatccctgt     3180

ccagcggtgt gcacaccttc ccagctgtcc tgcagtctga cctctacact ctgagcagct     3240

cagtgactgt cccctccagc acctggccca gcgagaccgt cacctgcaac gttgcccacc     3300

cggccagcag caccaaggtg gacaagaaaa ttgtgcccag ggattgtggt tgtaagcctt     3360

gcatatgtac agtcccagaa gtatcatctg tcttcatctt ccccccaaag cccaaggatg     3420

tgctcaccat tactctgact cctaaggtca cgtgtgttgt ggtagacatc agcaaggatg     3480

atcccgaggt ccagttcagc tggtttgtag atgatgtgga ggtgcacaca gctcagacgc     3540

aaccccggga ggagcagttc aacagcactt tccgctcagt cagtgaactt cccatcatgc     3600

accaggactg gctcaatggc aaggagacgt ccagattttg gcgatctatt caactgtcgc     3660

cagttcattg gtactggtag tctccctggg ggcaatcagt ttctggatgt gctctaatgg     3720

gtctctacag tgtagaatat gtatttaaag gccttagtcg tgtcgttttt caaataatat     3780

aatcctttta gggttttagt tagtttaaat tttctgttgc tcctgtttag caggtcgtgc     3840

cttcagcaag cacacaaaaa cagagtgttt attttaagtt gtttgtttag tgattcaaaa     3900

aaaaaatcgt tcaaacattt ggcaataaag tttcttaaga ttgaatcctg ttgccggtct     3960

tgcgatgatt atcatataat ttctgttgaa ttacgttaag catgtaataa ttaacatgta     4020

atgcatgacg ttatttatga gatgggtttt tatgattaga gtcccgcaat tatacattta     4080

atacgcgata gaaaacaaaa tatagcgcgc aaactaggat aaattatcgc gcgcggtgtc     4140

atctatgtta ctagatctct agagtctcaa gcttggcgcg cccacgtgac tagtggcact     4200

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     4260

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     4320

ttcccaacag ttgcgcagcc tgaatggcga atgctagagc agcttgagct tggatcagat     4380

tgtcgtttcc cgccttcagt ttaaactatc agtgtttgac aggatatatt ggcgggtaaa     4440

cctaagagaa aagagcgttt a                                               4461


<210>  34
<211>  5070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 8589 from 2X35S prom to NOS term

<400>  34
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggcac ttttctaatc aatcatcaaa cagaacgcag      780

aaaatttcct aaaaacaaaa aaaaggcata caaatggcga aaaacgttgc gattttcggc      840

ttattgtttt ctcttcttgt gttggttcct tctcagatct tcgcggtgaa tcttacgacg      900

cgaacacagt taccacccgc atatacaaat agcttcactc ggggtgttta ttaccccgac      960

aaagtgttca ggtcctccgt gctccactca acacaggacc tctttcttcc tttcttttct     1020

aacgtgacat ggtttcatgc cattcatgta tccggcacta acggtactaa gaggttcgat     1080

aatcctgtgc tccctttcaa tgacggcgtt tactttgcaa gcacagagaa gagtaacatc     1140

atccgaggtt ggatctttgg cactaccctc gattcaaaga cgcagagcct cctcattgtg     1200

aacaatgcca ctaacgtggt gatcaaagtt tgcgagtttc agttctgcaa tgaccctttc     1260

ttgggggtgt actatcataa gaacaacaag tcttggatgg aatctgaatt ccgcgtctat     1320

agcagcgcca acaactgcac ctttgaatac gtgtcccagc ccttccttat ggacctggag     1380

ggaaagcagg gaaactttaa gaatctgaga gagttcgtgt ttaaaaatat cgacggctat     1440

tttaagatct attctaagca cacgcctatt aatctcgtgc gcgatcttcc acaaggcttc     1500

agcgccctgg aaccactcgt ggacctccca attggtatca acatcactag atttcagact     1560

ctgcttgccc tccaccgatc ctatctgaca cccggagact cctctagcgg ctggactgcc     1620

ggcgctgccg cttattacgt tggttatctt cagccacgca cgttcctgct gaagtataac     1680

gagaatggta ctattaccga tgccgtggat tgtgcccttg accccctgtc cgaaactaag     1740

tgcacactca agtcattcac tgtggaaaaa ggaatctacc agacaagcaa ttttcgggtc     1800

cagcctactg agagcattgt gcgctttcct aacatcacaa atctttgccc cttcggagag     1860

gttttcaatg ctacacggtt tgcctccgtg tatgcctgga accgcaagag aatttccaat     1920

tgcgtggccg attactccgt gctctacaat agtgcaagct ttagcacctt taagtgctat     1980

ggcgtatccc ctactaagct taacgacttg tgtttcacaa acgtgtatgc cgactccttt     2040

gtgatacggg gcgacgaagt tagacagata gcaccaggac agacgggaaa gatagctgac     2100

tacaactata agcttcctga tgacttcact ggctgcgtta tcgcgtggaa ttctaacaac     2160

ctggactcaa aagtcggcgg caactataac tatctctatc ggctgttccg caagagtaac     2220

cttaagccct ttgagagaga tataagcact gaaatctacc aggctggcag tacgccctgt     2280

aatggcgtgg aaggctttaa ttgttatttt ccactgcaat cctatggttt tcagccaacc     2340

aatggcgtgg gctaccaacc ataccgcgtc gtggtgctct cctttgaact gctccacgct     2400

cccgcgactg tctgcggccc caagaagtcc acgaaccttg tgaagaataa gtgcgttaat     2460

tttaatttca acggcctcac tggaacagga gtgctcactg agagtaacaa gaagttcctg     2520

ccatttcaac aatttggcag agacatagcc gatactactg acgccgttag ggacccccag     2580

accctcgaga ttctcgatat aacgccctgc tccttcggtg gagtttccgt gatcacgcca     2640

ggcaccaata ccagtaacca ggtcgccgtg ctgtatcagg atgtcaactg tactgaggtg     2700

cccgtagcca tccatgcgga tcagctcaca ccaacttgga gggtgtacag caccggctcc     2760

aatgtattcc agactcgggc cggatgcctt attggcgccg aacacgtgaa caatagttac     2820

gaatgcgata ttccaattgg cgccggaatc tgtgctagct accagactca gacgaactcc     2880

ccaggcagcg ccagcagcgt tgccagccag tcaatcatcg cttatacaat gtcacttgga     2940

gccgaaaact ccgtggctta ctcaaacaac agcatcgcca tccccacaaa cttcaccata     3000

tccgtgacaa ctgagattct gccagtgtcc atgactaaga cgtccgtaga ttgcactatg     3060

tacatatgcg gcgacagcac agaatgttct aatctgctgc tgcaatatgg aagcttctgc     3120

actcaactga acagagcgct cacaggcatc gccgtggagc aggataagaa tacccaggag     3180

gtgttcgccc aagttaagca gatctacaag accccaccca taaaggattt cggtggattc     3240

aattttagtc agatactccc agacccatct aagccatcca agaggagctt tatcgaggat     3300

cttttgttta acaaagttac tctggccgac gccggtttca tcaagcagta cggagattgc     3360

ctcggcgaca tcgctgctcg tgacctcatc tgtgcgcaaa agtttaacgg tctgacggtg     3420

ctgcctcccc tccttactga tgaaatgatc gcccagtata ccagcgcact cctcgctggc     3480

accataacat ccggttggac attcggcgct ggtgcagcac tgcagatacc attcgccatg     3540

caaatggcat atcgtttcaa cggtatcggt gtcacacaga atgtcctata tgagaaccag     3600

aagctgatcg caaatcagtt caatagtgcc atcggaaaaa tccaggatag ccttagcagc     3660

acagcctcag cccttggcaa actccaggat gtcgtgaacc agaatgccca ggctctcaat     3720

accctcgtga agcagctctc atctaatttc ggcgcaattt ccagtgtcct caacgacatc     3780

ctcagccgcc tcgacccccc cgaggccgaa gtgcagattg acagactgat tacaggtcga     3840

ctccagagcc tccagactta cgtgactcag cagctgataa gagccgccga gataagggcc     3900

agcgctaacc tggctgccac aaagatgtct gagtgcgtgc tgggccagtc caagagagta     3960

gacttctgtg gcaaaggcta ccatctgatg agcttcccac aatccgcacc tcacggcgta     4020

gtgttcctcc acgtgacata tgtaccggct caggagaaga atttcactac cgctcctgct     4080

atatgccatg atggaaaggc tcacttcccc cgggaggggg tgttcgtgtc caacggcacc     4140

cattggtttg tgactcagcg gaatttctac gaaccccaga tcataaccac tgacaacaca     4200

tttgtgtccg gaaattgtga cgtggtcatt ggaatagtga acaacactgt ttatgatcca     4260

ctgcagccag aacttgacag ctttaaggag gagctcgaca agtacttcaa gaatcatacg     4320

tcaccagatg tggacctcgg agatattagc ggtatcaatg ccagtgttgt caatattcag     4380

aaggaaatag accgccttaa tgaggtcgcc aaaaatctga acgagagcct catcgatctt     4440

caggagctgg gcaaatatga gcagtacatc aagtggcctt ggtatatttg gcttggcttc     4500

atcgccggcc tgatcgccat agtaatggtc acaattatgc tctgctgcat gacctcttgc     4560

tgctcctgtc tgaaaggctg ctgctcttgc ggatcctgct gcaaatttga tgaggatgac     4620

agtgaaccag tcctgaaggg cgtgaagctg cactatactt agaggcctta gtcgtgtcgt     4680

ttttcaaata atataatcct tttagggttt tagttagttt aaattttctg ttgctcctgt     4740

ttagcaggtc gtgccttcag caagcacaca aaaacagagt gtttatttta agttgtttgt     4800

ttagtgattc aaaaaaaaaa tcgttcaaac atttggcaat aaagtttctt aagattgaat     4860

cctgttgccg gtcttgcgat gattatcata taatttctgt tgaattacgt taagcatgta     4920

ataattaaca tgtaatgcat gacgttattt atgagatggg tttttatgat tagagtcccg     4980

caattataca tttaatacgc gatagaaaac aaaatatagc gcgcaaacta ggataaatta     5040

tcgcgcgcgg tgtcatctat gttactagat                                      5070


<210>  35
<211>  4436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cloning vector 8716 from left to right T-DNA

<400>  35
tggcaggata tattgtggtg taaacaaatt gacgcttaga caacttaata acacattgcg       60

gacgttttta atgtactgaa ttaacgccga atcccgggct ggtatattta tatgttgtca      120

aataactcaa aaaccataaa agtttaagtt agcaagtgtg tacattttta cttgaacaaa      180

aatattcacc tactactgtt ataaatcatt attaaacatt agagtaaaga aatatggatg      240

ataagaacaa gagtagtgat attttgacaa caattttgtt gcaacatttg agaaaatttt      300

gttgttctct cttttcattg gtcaaaaaca atagagagag aaaaaggaag agggagaata      360

aaaacataat gtgagtatga gagagaaagt tgtacaaaag ttgtaccaaa atagttgtac      420

aaatatcatt gaggaatttg acaaaagcta cacaaataag ggttaattgc tgtaaataaa      480

taaggatgac gcattagaga gatgtaccat tagagaattt ttggcaagtc attaaaaaga      540

aagaataaat tatttttaaa attaaaagtt gagtcatttg attaaacatg tgattattta      600

atgaattgat gaaagagttg gattaaagtt gtattagtaa ttagaatttg gtgtcaaatt      660

taatttgaca tttgatcttt tcctatatat tgccccatag agtcagttaa ctcattttta      720

tatttcatag atcaaataag agaaataacg gtatattaat ccctccaaaa aaaaaaaacg      780

gtatatttac taaaaaatct aagccacgta ggaggataac aggatccccg taggaggata      840

acatccaatc caaccaatca caacaatcct gatgagataa cccactttaa gcccacgcat      900

ctgtggcaca tctacattat ctaaatcaca cattcttcca cacatctgag ccacacaaaa      960

accaatccac atctttatca cccattctat aaaaaatcac actttgtgag tctacacttt     1020

gattcccttc aaacacatac aaagagaaga gactaattaa ttaattaatc atcttgagag     1080

aaaatggaac gagctataca aggaaacgac gctagggaac aagctaacag tgaacgttgg     1140

gatggaggat caggaggtac cacttctccc ttcaaacttc ctgacgaaag tccgagttgg     1200

actgagtggc ggctacataa cgatgagacg aattcgaatc aagataatcc ccttggtttc     1260

aaggaaagct ggggtttcgg gaaagttgta tttaagagat atctcagata cgacaggacg     1320

gaagcttcac tgcacagagt ccttggatct tggacgggag attcggttaa ctatgcagca     1380

tctcgatttt tcggtttcga ccagatcgga tgtacctata gtattcggtt tcgaggagtt     1440

agtatcaccg tttctggagg gtcgcgaact cttcagcatc tctgtgagat ggcaattcgg     1500

tctaagcaag aactgctaca gcttgcccca atcgaagtgg aaagtaatgt atcaagagga     1560

tgccctgaag gtactcaaac cttcgaaaaa gaaagcgagt aagttaaaat gcttcttcgt     1620

ctcctattta taatatggtt tgttattgtt aattttgttc ttgtagaaga gcttaattaa     1680

tcgttgttgt tatgaaatac tatttgtatg agatgaactg gtgtaatgta attcatttac     1740

ataagtggag tcagaatcag aatgtttcct ccataactaa ctagacatga agacctgccg     1800

cgtacaattg tcttatattt gaacaactaa aattgaacat cttttgccac aactttataa     1860

gtggttaata tagctcaaat atatggtcaa gttcaataga ttaataatgg aaatatcagt     1920

tatcgaaatt cattaacaat caacttaacg ttattaacta ctaattttat atcatcccct     1980

ttgataaatg atagtacacc aattaggaag gagcatgctc gcctaggaga ttgtcgtttc     2040

ccgccttcag tttgcaagct gctctagccg tgtagccaat acgcaaaccg cctctccccg     2100

cgcgttggga attactagcg cgtgtcgaca agcttgcatg ccggtcaaca tggtggagca     2160

cgacacactt gtctactcca aaaatatcaa agatacagtc tcagaagacc aaagggcaat     2220

tgagactttt caacaaaggg taatatccgg aaacctcctc ggattccatt gcccagctat     2280

ctgtcacttt attgtgaaga tagtggaaaa ggaaggtggc tcctacaaat gccatcattg     2340

cgataaagga aaggccatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc     2400

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt     2460

ggattgatgt gataacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga     2520

tacagtctca gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa     2580

cctcctcgga ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga     2640

aggtggctcc tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc     2700

tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga     2760

cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg acgtaaggga     2820

tgacgcacaa tcccactatc cttcgcaaga cccttcctct atataaggaa gttcatttca     2880

tttggagagg cactccattt gaatctatca aaccaaaaca cattgagcaa aatggcgaaa     2940

aacgttgcga ttttcggctt attgttttct cttcttgtgt tggttccttc tcagatcttc     3000

gcgacgtcac tcctcagcca aaacgacacc cccatctgtc tatccactgg cccctggatc     3060

tgctgcccaa actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga     3120

gccagtgaca gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc     3180

tgtcctgcag tctgacctct acactctgag cagctcagtg actgtcccct ccagcacctg     3240

gcccagcgag accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa     3300

gaaaattgtg cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc     3360

atctgtcttc atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa     3420

ggtcacgtgt gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt     3480

tgtagatgat gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag     3540

cactttccgc tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga     3600

gacgtccaga ttttggcgat ctattcaact gtcgccagtt cattggtact ggtagtctcc     3660

ctgggggcaa tcagtttctg gatgtgctct aatgggtctc tacagtgtag aatatgtatt     3720

taaaggcctt agtcgtgtcg tttttcaaat aatataatcc ttttagggtt ttagttagtt     3780

taaattttct gttgctcctg tttagcaggt cgtgccttca gcaagcacac aaaaacagag     3840

tgtttatttt aagttgtttg tttagtgatt caaaaaaaaa atcgttcaaa catttggcaa     3900

taaagtttct taagattgaa tcctgttgcc ggtcttgcga tgattatcat ataatttctg     3960

ttgaattacg ttaagcatgt aataattaac atgtaatgca tgacgttatt tatgagatgg     4020

gtttttatga ttagagtccc gcaattatac atttaatacg cgatagaaaa caaaatatag     4080

cgcgcaaact aggataaatt atcgcgcgcg gtgtcatcta tgttactaga tctctagagt     4140

ctcaagcttg gcgcgcccac gtgactagtg gcactggccg tcgttttaca acgtcgtgac     4200

tgggaaaacc ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc     4260

tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat     4320

ggcgaatgct agagcagctt gagcttggat cagattgtcg tttcccgcct tcagtttaaa     4380

ctatcagtgt ttgacaggat atattggcgg gtaaacctaa gagaaaagag cgttta         4436


<210>  36
<211>  5045
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 8591 from 2X35S prom to NOS term

<400>  36
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggcac tccatttgaa tctatcaaac caaaacacat      780

tgagcaaaat ggcgaaaaac gttgcgattt tcggcttatt gttttctctt cttgtgttgg      840

ttccttctca gatcttcgcg gtgaatctta cgacgcgaac acagttacca cccgcatata      900

caaatagctt cactcggggt gtttattacc ccgacaaagt gttcaggtcc tccgtgctcc      960

actcaacaca ggacctcttt cttcctttct tttctaacgt gacatggttt catgccattc     1020

atgtatccgg cactaacggt actaagaggt tcgataatcc tgtgctccct ttcaatgacg     1080

gcgtttactt tgcaagcaca gagaagagta acatcatccg aggttggatc tttggcacta     1140

ccctcgattc aaagacgcag agcctcctca ttgtgaacaa tgccactaac gtggtgatca     1200

aagtttgcga gtttcagttc tgcaatgacc ctttcttggg ggtgtactat cataagaaca     1260

acaagtcttg gatggaatct gaattccgcg tctatagcag cgccaacaac tgcacctttg     1320

aatacgtgtc ccagcccttc cttatggacc tggagggaaa gcagggaaac tttaagaatc     1380

tgagagagtt cgtgtttaaa aatatcgacg gctattttaa gatctattct aagcacacgc     1440

ctattaatct cgtgcgcgat cttccacaag gcttcagcgc cctggaacca ctcgtggacc     1500

tcccaattgg tatcaacatc actagatttc agactctgct tgccctccac cgatcctatc     1560

tgacacccgg agactcctct agcggctgga ctgccggcgc tgccgcttat tacgttggtt     1620

atcttcagcc acgcacgttc ctgctgaagt ataacgagaa tggtactatt accgatgccg     1680

tggattgtgc ccttgacccc ctgtccgaaa ctaagtgcac actcaagtca ttcactgtgg     1740

aaaaaggaat ctaccagaca agcaattttc gggtccagcc tactgagagc attgtgcgct     1800

ttcctaacat cacaaatctt tgccccttcg gagaggtttt caatgctaca cggtttgcct     1860

ccgtgtatgc ctggaaccgc aagagaattt ccaattgcgt ggccgattac tccgtgctct     1920

acaatagtgc aagctttagc acctttaagt gctatggcgt atcccctact aagcttaacg     1980

acttgtgttt cacaaacgtg tatgccgact cctttgtgat acggggcgac gaagttagac     2040

agatagcacc aggacagacg ggaaagatag ctgactacaa ctataagctt cctgatgact     2100

tcactggctg cgttatcgcg tggaattcta acaacctgga ctcaaaagtc ggcggcaact     2160

ataactatct ctatcggctg ttccgcaaga gtaaccttaa gccctttgag agagatataa     2220

gcactgaaat ctaccaggct ggcagtacgc cctgtaatgg cgtggaaggc tttaattgtt     2280

attttccact gcaatcctat ggttttcagc caaccaatgg cgtgggctac caaccatacc     2340

gcgtcgtggt gctctccttt gaactgctcc acgctcccgc gactgtctgc ggccccaaga     2400

agtccacgaa ccttgtgaag aataagtgcg ttaattttaa tttcaacggc ctcactggaa     2460

caggagtgct cactgagagt aacaagaagt tcctgccatt tcaacaattt ggcagagaca     2520

tagccgatac tactgacgcc gttagggacc cccagaccct cgagattctc gatataacgc     2580

cctgctcctt cggtggagtt tccgtgatca cgccaggcac caataccagt aaccaggtcg     2640

ccgtgctgta tcaggatgtc aactgtactg aggtgcccgt agccatccat gcggatcagc     2700

tcacaccaac ttggagggtg tacagcaccg gctccaatgt attccagact cgggccggat     2760

gccttattgg cgccgaacac gtgaacaata gttacgaatg cgatattcca attggcgccg     2820

gaatctgtgc tagctaccag actcagacga actccccagg cagcgccagc agcgttgcca     2880

gccagtcaat catcgcttat acaatgtcac ttggagccga aaactccgtg gcttactcaa     2940

acaacagcat cgccatcccc acaaacttca ccatatccgt gacaactgag attctgccag     3000

tgtccatgac taagacgtcc gtagattgca ctatgtacat atgcggcgac agcacagaat     3060

gttctaatct gctgctgcaa tatggaagct tctgcactca actgaacaga gcgctcacag     3120

gcatcgccgt ggagcaggat aagaataccc aggaggtgtt cgcccaagtt aagcagatct     3180

acaagacccc acccataaag gatttcggtg gattcaattt tagtcagata ctcccagacc     3240

catctaagcc atccaagagg agctttatcg aggatctttt gtttaacaaa gttactctgg     3300

ccgacgccgg tttcatcaag cagtacggag attgcctcgg cgacatcgct gctcgtgacc     3360

tcatctgtgc gcaaaagttt aacggtctga cggtgctgcc tcccctcctt actgatgaaa     3420

tgatcgccca gtataccagc gcactcctcg ctggcaccat aacatccggt tggacattcg     3480

gcgctggtgc agcactgcag ataccattcg ccatgcaaat ggcatatcgt ttcaacggta     3540

tcggtgtcac acagaatgtc ctatatgaga accagaagct gatcgcaaat cagttcaata     3600

gtgccatcgg aaaaatccag gatagcctta gcagcacagc ctcagccctt ggcaaactcc     3660

aggatgtcgt gaaccagaat gcccaggctc tcaataccct cgtgaagcag ctctcatcta     3720

atttcggcgc aatttccagt gtcctcaacg acatcctcag ccgcctcgac ccccccgagg     3780

ccgaagtgca gattgacaga ctgattacag gtcgactcca gagcctccag acttacgtga     3840

ctcagcagct gataagagcc gccgagataa gggccagcgc taacctggct gccacaaaga     3900

tgtctgagtg cgtgctgggc cagtccaaga gagtagactt ctgtggcaaa ggctaccatc     3960

tgatgagctt cccacaatcc gcacctcacg gcgtagtgtt cctccacgtg acatatgtac     4020

cggctcagga gaagaatttc actaccgctc ctgctatatg ccatgatgga aaggctcact     4080

tcccccggga gggggtgttc gtgtccaacg gcacccattg gtttgtgact cagcggaatt     4140

tctacgaacc ccagatcata accactgaca acacatttgt gtccggaaat tgtgacgtgg     4200

tcattggaat agtgaacaac actgtttatg atccactgca gccagaactt gacagcttta     4260

aggaggagct cgacaagtac ttcaagaatc atacgtcacc agatgtggac ctcggagata     4320

ttagcggtat caatgccagt gttgtcaata ttcagaagga aatagaccgc cttaatgagg     4380

tcgccaaaaa tctgaacgag agcctcatcg atcttcagga gctgggcaaa tatgagcagt     4440

acatcaagtg gccttggtat atttggcttg gcttcatcgc cggcctgatc gccatagtaa     4500

tggtcacaat tatgctctgc tgcatgacct cttgctgctc ctgtctgaaa ggctgctgct     4560

cttgcggatc ctgctgcaaa tttgatgagg atgacagtga accagtcctg aagggcgtga     4620

agctgcacta tacttagagg ccttagtcgt gtcgtttttc aaataatata atccttttag     4680

ggttttagtt agtttaaatt ttctgttgct cctgtttagc aggtcgtgcc ttcagcaagc     4740

acacaaaaac agagtgttta ttttaagttg tttgtttagt gattcaaaaa aaaaatcgtt     4800

caaacatttg gcaataaagt ttcttaagat tgaatcctgt tgccggtctt gcgatgatta     4860

tcatataatt tctgttgaat tacgttaagc atgtaataat taacatgtaa tgcatgacgt     4920

tatttatgag atgggttttt atgattagag tcccgcaatt atacatttaa tacgcgatag     4980

aaaacaaaat atagcgcgca aactaggata aattatcgcg cgcggtgtca tctatgttac     5040

tagat                                                                 5045


<210>  37
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-Terminal Region of Modified SARS-CoV-2 S protein with H5i 
       Hemagglutinin CT, Variation 2

<400>  37

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser 
            20                  25                  30          


Leu Gln Cys Arg Ile Cys Ile 
        35                  


<210>  38
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-Terminal Region of Modified SARS-CoV-2 S protein with H5i 
       Hemagglutinin CT, Variation 3

<400>  38

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Cys Cys Met Cys Ser Asn Gly Ser Leu Gln Cys 
            20                  25                  30          


Arg Ile Cys Ile 
        35      


<210>  39
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-Terminal Region of Modified SARS-CoV-2 S protein with H5i 
       Hemagglutinin CT, Variation 4

<400>  39

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Cys Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
            20                  25                  30          


Cys Ile 
        


<210>  40
<211>  151
<212>  DNA
<213>  Arracacha Virus B

<400>  40
tagtcgtgtc gtttttcaaa taatataatc cttttagggt tttagttagt ttaaattttc       60

tgttgctcct gtttagcagg tcgtgccttc agcaagcaca caaaaacaga gtgtttattt      120

taagttgttt gtttagtgat tcaaaaaaaa a                                     151


<210>  41
<211>  182
<212>  DNA
<213>  Beet necrotic yellow vein virus

<400>  41
cctatcttga tgaaggttgt tgtggttttc tcattactgt tttattattg tttgagttgc       60

ttatgtcggt tcttgattat gtggtgcata attattgaac taattgtttg ttgggttgta      120

atgtactgac tgggtgtgaa ttgtaccagt cgttaaaggg tttactatca gtatattgat      180

at                                                                     182


<210>  42
<211>  132
<212>  DNA
<213>  Southern bean mosaic virus

<400>  42
tgaggagttg tataataata cctgcaccct tctctttggc agggagggtg tttcgttttc       60

acaatgccac gcgcttgagg gagaatgcac gttaatcatc cctccgctag tgatggagcg      120

taatccaaaa gt                                                          132


<210>  43
<211>  282
<212>  DNA
<213>  Turnip ringspot virus

<400>  43
tgatttataa tagccataga ttaagtttaa atgtattacg tttgtatttt attctctttt       60

ttaagtttcc tatgttgttt taaattaaat atctgtataa ttagtagatg taaatctgct      120

ttgtgcgttt gacagtctgt ggaaacgcac tggttcatga gataggacca cctaggaggt      180

aggactctgg gttttaatta tctcatttct tagttatacc gtattatata tatgatttag      240

tagtaattgt tttctcttga tatgtattat tactttttta tt                         282


<210>  44
<211>  165
<212>  DNA
<213>  Cowpea Mosaic virus

<400>  44
attttcttta gtttgaattt actgttattc ggtgtgcatt tctatgtttg gtgagcggtt       60

ttctgtgctc agagtgtgtt tattttatgt aatttaattt ctttgtgagc tcctgtttag      120

caggtcgtcc cttcagcaag gacacaaaaa gattttaatt ttatt                      165


<210>  45
<211>  275
<212>  DNA
<213>  Broad bean true mosaic virus

<400>  45
tagttttctt ccgcttttct tttgtagtgt gtggttttct ttgtttcttc ttttcttttc       60

tctttccttt tctcttactc ctgcctggca ggtcgtgcct tcagtaagca caacaaaaat      120

atgcatttat tagagtattt ctttcttctt tagcataaag gtattgaaga cctataaact      180

tcgtccgggt tggggaaagt accagcttag catatcttta gaaaactata tagagctctt      240

taccttgagt tgtttcctaa agtttatgca aaaaa                                 275


<210>  46
<211>  147
<212>  DNA
<213>  Ourmia melon virus

<400>  46
ctcacgtctg gggtgagccc tagccaaata ggaaaacgat aagcgctttg catgcaaaat       60

gagttgggcc acaagtgcca ctcgcagcga aggcggtctg aggtttcccc ctggcggtta      120

cttccatatc tttgggagat aactggg                                          147


<210>  47
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with H5i 
       Hemagglutinin CT AA

<400>  47

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Ser Leu  Trp Met Cys 
    1235                 1240                 1245             


Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys Ile 
    1250                 1255                 


<210>  48
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+4P with H5i 
       Hemagglutinin CT AA

<400>  48

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Ser Leu  Trp Met Cys 
    1235                 1240                 1245             


Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys Ile 
    1250                 1255                 


<210>  49
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+6P with H5i 
       Hemagglutinin CT AA

<400>  49

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Ser Leu  Trp Met Cys 
    1235                 1240                 1245             


Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys Ile 
    1250                 1255                 


<210>  50
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP+923 with H5i 
       Hemagglutinin CT AA

<400>  50

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Phe Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Ser Leu  Trp Met Cys 
    1235                 1240                 1245             


Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys Ile 
    1250                 1255                 


<210>  51
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+4P+923 with H5i 
       Hemagglutinin CT AA

<400>  51

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Phe Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Ser Leu  Trp Met Cys 
    1235                 1240                 1245             


Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys Ile 
    1250                 1255                 


<210>  52
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+6P+923 with H5i 
       Hemagglutinin CT AA

<400>  52

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Phe Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Ser Leu  Trp Met Cys 
    1235                 1240                 1245             


Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys Ile 
    1250                 1255                 


<210>  53
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with H1 Cal 
       Hemagglutinin CT AA

<400>  53

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Ser Phe  Trp Met Cys 
    1235                 1240                 1245             


Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys Ile 
    1250                 1255                 


<210>  54
<211>  1258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with H3 Minn 
       Hemagglutinin CT AA

<400>  54

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Met Trp  Ala Cys Gln 
    1235                 1240                 1245             


Lys Gly  Asn Ile Arg Cys Asn  Ile Cys Ile 
    1250                 1255             


<210>  55
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with H6 HK 
       Hemagglutinin CT AA

<400>  55

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Gly Leu  Trp Met Cys 
    1235                 1240                 1245             


Ser Asn  Gly Ser Met Gln Cys  Arg Ile Cys Ile 
    1250                 1255                 


<210>  56
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with H7 Guangdong 
       Hemagglutinin CT AA

<400>  56

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Val Phe  Ile Cys Val 
    1235                 1240                 1245             


Lys Asn  Gly Asn Met Arg Cys  Thr Ile Cys Ile 
    1250                 1255                 


<210>  57
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with H9 HK 
       Hemagglutinin CT AA

<400>  57

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Leu Phe  Trp Ala Met 
    1235                 1240                 1245             


Ser Asn  Gly Ser Cys Arg Cys  Asn Ile Cys Ile 
    1250                 1255                 


<210>  58
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with B/Wash 
       Hemagglutinin CT AA

<400>  58

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Val Val  Tyr Met Val 
    1235                 1240                 1245             


Ser Arg  Asp Asn Val Ser Cys  Ser Ile Cys Leu 
    1250                 1255                 


<210>  59
<211>  1262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with H5i 
       Hemagglutinin CT (alternative 1) AA

<400>  59

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Met Ala Gly  Leu Ser Leu 
    1235                 1240                 1245             


Trp Met  Cys Ser Asn Gly Ser  Leu Gln Cys Arg Ile  Cys Ile 
    1250                 1255                 1260         


<210>  60
<211>  1261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with H5i 
       Hemagglutinin CT (alternative 2) AA

<400>  60

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Ala Gly Leu  Ser Leu Trp 
    1235                 1240                 1245             


Met Cys  Ser Asn Gly Ser Leu  Gln Cys Arg Ile Cys  Ile 
    1250                 1255                 1260     


<210>  61
<211>  1258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PDI) Modified SARS-CoV-2 S protein GSAS+PP with H5i 
       Hemagglutinin CT (alternative 3) AA

<400>  61

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Met Cys Ser 
    1235                 1240                 1245             


Asn Gly  Ser Leu Gln Cys Arg  Ile Cys Ile 
    1250                 1255             


<210>  62
<211>  1256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI) Modified SARS-CoV-2 S protein GSAS+PP with H5i Hemagglutinin
       CT (alternative 4) AA

<400>  62

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Ser Asn Gly 
    1235                 1240                 1245             


Ser Leu  Gln Cys Arg Ile Cys  Ile 
    1250                 1255     


<210>  63
<211>  31
<212>  PRT
<213>  SARS-CoV-2

<400>  63

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
            20                  25                  30      


<210>  64
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TMCT with intervening peptide sequence (X)n


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa may be  any combination of 0 to 10 amino acids

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  64

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Xaa Cys Ser Asn Gly Ser Xaa Xaa Cys Xaa Ile Cys 
            20                  25                  30          


Ile 
    


<210>  65
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S Protein GSAS+4P-DNA

<400>  65
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagccccat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca ccctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctct ctttatggat gtgctccaat ggatcgttac aatgcagaat ttgcatttaa     3780


<210>  66
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S Protein GSAS+6P-DNA

<400>  66
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagccccat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

cccgcactgc agataccatt ccccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca ccctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctct ctttatggat gtgctccaat ggatcgttac aatgcagaat ttgcatttaa     3780


<210>  67
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S Protein GSAS+2P+L923F-DNA

<400>  67
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagctt cagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctct ctttatggat gtgctccaat ggatcgttac aatgcagaat ttgcatttaa     3780


<210>  68
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S Protein GSAS+4P+L923F-DNA

<400>  68
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagccccat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagctt cagcagcaca ccctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctct ctttatggat gtgctccaat ggatcgttac aatgcagaat ttgcatttaa     3780


<210>  69
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S Protein GSAS+6P+L923F-DNA

<400>  69
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagccccat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

cccgcactgc agataccatt ccccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagctt cagcagcaca ccctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctct ctttatggat gtgctccaat ggatcgttac aatgcagaat ttgcatttaa     3780


<210>  70
<211>  3789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-Modified S protein with H5i Hemagglutinin CT (V1) DNA

<400>  70
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgatgg ccggcctctc tttatggatg tgctccaatg gatcgttaca atgcagaatt     3780

tgcatttaa                                                             3789


<210>  71
<211>  3786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-Modified S protein with H5i Hemagglutinin CT (V2) DNA

<400>  71
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatggccg gcctctcttt atggatgtgc tccaatggat cgttacaatg cagaatttgc     3780

atttaa                                                                3786


<210>  72
<211>  3777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-Modified S protein with H5i Hemagglutinin CT (V3) DNA

<400>  72
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctct gctgcatgtg ctccaatgga tcgttacaat gcagaatttg catttaa        3777


<210>  73
<211>  3771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-Modified S protein with H5i Hemagglutinin CT (V4) DNA

<400>  73
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctct gctgctccaa tggatcgtta caatgcagaa tttgcattta a              3771


<210>  74
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S-protein+H1 Cal DNA

<400>  74
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctca gcttctggat gtgctctaat gggtctctac agtgtagaat atgtatttaa     3780


<210>  75
<211>  3777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S-protein+H3 Minn DNA

<400>  75
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctca tgtgggcctg tcagaagggc aacatcagat gcaacatctg catctaa        3777


<210>  76
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S-protein+H6 HK DNA

<400>  76
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctcg gtctttggat gtgttcaaat ggttcaatgc agtgcaggat atgtatataa     3780


<210>  77
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S-protein+H7 Guangdong DNA

<400>  77
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctcg tcttcatatg tgtgaagaat ggaaacatgc ggtgcactat ttgtatataa     3780


<210>  78
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S-protein+H9 HK DNA

<400>  78
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctcc tgttctgggc catgtccaat ggatcttgca gatgcaacat ttgtatataa     3780


<210>  79
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-S-protein+ B/ Wash DNA

<400>  79
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgaatct tacgacgcga acacagttac cacccgcata tacaaatagc      120

ttcactcggg gtgtttatta ccccgacaaa gtgttcaggt cctccgtgct ccactcaaca      180

caggacctct ttcttccttt cttttctaac gtgacatggt ttcatgccat tcatgtatcc      240

ggcactaacg gtactaagag gttcgataat cctgtgctcc ctttcaatga cggcgtttac      300

tttgcaagca cagagaagag taacatcatc cgaggttgga tctttggcac taccctcgat      360

tcaaagacgc agagcctcct cattgtgaac aatgccacta acgtggtgat caaagtttgc      420

gagtttcagt tctgcaatga ccctttcttg ggggtgtact atcataagaa caacaagtct      480

tggatggaat ctgaattccg cgtctatagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagccct tccttatgga cctggaggga aagcagggaa actttaagaa tctgagagag      600

ttcgtgttta aaaatatcga cggctatttt aagatctatt ctaagcacac gcctattaat      660

ctcgtgcgcg atcttccaca aggcttcagc gccctggaac cactcgtgga cctcccaatt      720

ggtatcaaca tcactagatt tcagactctg cttgccctcc accgatccta tctgacaccc      780

ggagactcct ctagcggctg gactgccggc gctgccgctt attacgttgg ttatcttcag      840

ccacgcacgt tcctgctgaa gtataacgag aatggtacta ttaccgatgc cgtggattgt      900

gcccttgacc ccctgtccga aactaagtgc acactcaagt cattcactgt ggaaaaagga      960

atctaccaga caagcaattt tcgggtccag cctactgaga gcattgtgcg ctttcctaac     1020

atcacaaatc tttgcccctt cggagaggtt ttcaatgcta cacggtttgc ctccgtgtat     1080

gcctggaacc gcaagagaat ttccaattgc gtggccgatt actccgtgct ctacaatagt     1140

gcaagcttta gcacctttaa gtgctatggc gtatccccta ctaagcttaa cgacttgtgt     1200

ttcacaaacg tgtatgccga ctcctttgtg atacggggcg acgaagttag acagatagca     1260

ccaggacaga cgggaaagat agctgactac aactataagc ttcctgatga cttcactggc     1320

tgcgttatcg cgtggaattc taacaacctg gactcaaaag tcggcggcaa ctataactat     1380

ctctatcggc tgttccgcaa gagtaacctt aagccctttg agagagatat aagcactgaa     1440

atctaccagg ctggcagtac gccctgtaat ggcgtggaag gctttaattg ttattttcca     1500

ctgcaatcct atggttttca gccaaccaat ggcgtgggct accaaccata ccgcgtcgtg     1560

gtgctctcct ttgaactgct ccacgctccc gcgactgtct gcggccccaa gaagtccacg     1620

aaccttgtga agaataagtg cgttaatttt aatttcaacg gcctcactgg aacaggagtg     1680

ctcactgaga gtaacaagaa gttcctgcca tttcaacaat ttggcagaga catagccgat     1740

actactgacg ccgttaggga cccccagacc ctcgagattc tcgatataac gccctgctcc     1800

ttcggtggag tttccgtgat cacgccaggc accaatacca gtaaccaggt cgccgtgctg     1860

tatcaggatg tcaactgtac tgaggtgccc gtagccatcc atgcggatca gctcacacca     1920

acttggaggg tgtacagcac cggctccaat gtattccaga ctcgggccgg atgccttatt     1980

ggcgccgaac acgtgaacaa tagttacgaa tgcgatattc caattggcgc cggaatctgt     2040

gctagctacc agactcagac gaactcccca ggcagcgcca gcagcgttgc cagccagtca     2100

atcatcgctt atacaatgtc acttggagcc gaaaactccg tggcttactc aaacaacagc     2160

atcgccatcc ccacaaactt caccatatcc gtgacaactg agattctgcc agtgtccatg     2220

actaagacgt ccgtagattg cactatgtac atatgcggcg acagcacaga atgttctaat     2280

ctgctgctgc aatatggaag cttctgcact caactgaaca gagcgctcac aggcatcgcc     2340

gtggagcagg ataagaatac ccaggaggtg ttcgcccaag ttaagcagat ctacaagacc     2400

ccacccataa aggatttcgg tggattcaat tttagtcaga tactcccaga cccatctaag     2460

ccatccaaga ggagctttat cgaggatctt ttgtttaaca aagttactct ggccgacgcc     2520

ggtttcatca agcagtacgg agattgcctc ggcgacatcg ctgctcgtga cctcatctgt     2580

gcgcaaaagt ttaacggtct gacggtgctg cctcccctcc ttactgatga aatgatcgcc     2640

cagtatacca gcgcactcct cgctggcacc ataacatccg gttggacatt cggcgctggt     2700

gcagcactgc agataccatt cgccatgcaa atggcatatc gtttcaacgg tatcggtgtc     2760

acacagaatg tcctatatga gaaccagaag ctgatcgcaa atcagttcaa tagtgccatc     2820

ggaaaaatcc aggatagcct tagcagcaca gcctcagccc ttggcaaact ccaggatgtc     2880

gtgaaccaga atgcccaggc tctcaatacc ctcgtgaagc agctctcatc taatttcggc     2940

gcaatttcca gtgtcctcaa cgacatcctc agccgcctcg acccccccga ggccgaagtg     3000

cagattgaca gactgattac aggtcgactc cagagcctcc agacttacgt gactcagcag     3060

ctgataagag ccgccgagat aagggccagc gctaacctgg ctgccacaaa gatgtctgag     3120

tgcgtgctgg gccagtccaa gagagtagac ttctgtggca aaggctacca tctgatgagc     3180

ttcccacaat ccgcacctca cggcgtagtg ttcctccacg tgacatatgt accggctcag     3240

gagaagaatt tcactaccgc tcctgctata tgccatgatg gaaaggctca cttcccccgg     3300

gagggggtgt tcgtgtccaa cggcacccat tggtttgtga ctcagcggaa tttctacgaa     3360

ccccagatca taaccactga caacacattt gtgtccggaa attgtgacgt ggtcattgga     3420

atagtgaaca acactgttta tgatccactg cagccagaac ttgacagctt taaggaggag     3480

ctcgacaagt acttcaagaa tcatacgtca ccagatgtgg acctcggaga tattagcggt     3540

atcaatgcca gtgttgtcaa tattcagaag gaaatagacc gccttaatga ggtcgccaaa     3600

aatctgaacg agagcctcat cgatcttcag gagctgggca aatatgagca gtacatcaag     3660

tggccttggt atatttggct tggcttcatc gccggcctga tcgccatagt aatggtcaca     3720

attatgctcg ttgtttatat ggtctccaga gacaatgttt cttgctccat ttgtctataa     3780


<210>  80
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-H1HawaiiCT.r

<400>  80
acgacacgac taaggccttt aaatacatat tctacactgt agagaccc                    48


<210>  81
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-H3MinnesotaCT.r

<400>  81
acgacacgac taaggccttt agatgcagat gttgcatctg atgttgccct tctg             54


<210>  82
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-HongKongCT.r

<400>  82
acgacacgac taaggccttt atatacatat cctgcactgc attgaaccat tt               52


<210>  83
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-GuangdongCT.r

<400>  83
acgacacgac taaggccttt atatacaaat agtgcaccgc atgtttcca                   49


<210>  84
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-H9HKCT.r

<400>  84
acgacacgac taaggccttt atatacaaat gttgcatctg caagatccat                  50


<210>  85
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-BWashCT.r

<400>  85
acgacacgac taaggccttt atagacaaat ggagcaagaa acattgtctc                  50


<210>  86
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(nbHEL40)-PDI.c

<400>  86
ccaaaacaca ttgagcaaaa tggcgaaaaa cgttgcgatt ttcggcttat                  50


<210>  87
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(AvB+wtCT).r

<400>  87
acgacacgac taaggccttt aggtataatg gagtttcacc cccttcagaa                  50


<210>  88
<211>  3801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 wtTMCT-DNA

<400>  88
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtccgatct ggatcggtgc actacatttg acgatgtgca ggcacctaat      120

tatactcagc acacctcttc catgcggggc gtgtactacc ccgacgagat ttttagaagt      180

gacacactgt acctgaccca agaccttttt ctcccatttt atagcaatgt cacgggattc      240

cacactatca atcacacatt cggaaaccct gttatcccct ttaaagacgg tatctacttt      300

gctgctactg agaaatcgaa tgttgttcgc ggttgggtgt tcggctcaac catgaacaac      360

aagagtcagt cagtaataat tataaacaac tcaaccaatg tcgtcatcag ggcttgcaac      420

ttcgagctct gcgataaccc cttctttgcg gtgtccaaac cgatgggcac tcagacccat      480

accatgattt ttgacaatgc ctttaattgt actttcgaat acatcagcga tgccttctcg      540

ctggatgtgt ccgagaagag cggtaacttc aagcatttgc gggagttcgt tttcaaaaac      600

aaagacgggt ttttgtatgt ctacaaaggc tatcagccca ttgatgtggt cagggatctg      660

cccagtggtt tcaacacact gaagcccatc ttcaagttgc cactcggcat caacatcact      720

aatttccgcg ccatcctaac tgctttttcg ccagcgcagg atatttgggg gacatccgcc      780

gcagcttact tcgtgggata tctgaagccc accactttta tgctaaagta cgacgagaat      840

ggcaccatca ccgatgccgt ggactgctca cagaatcctc tcgcagagct caagtgttca      900

gtgaagtcat ttgagatcga caaagggatc taccaaacat ctaactttcg cgtcgtgcct      960

tccggtgacg tagtccgttt cccaaatatc actaacttgt gcccttttgg tgaagtattc     1020

aacgcaacca aattccccag tgtgtatgcg tgggagcgca aaaagatcag taactgtgtg     1080

gctgactata gtgttctgta caatagcacc ttcttcagca ccttcaagtg ttatggagtg     1140

agcgctacaa aactgaacga tctttgtttc tcaaacgtgt acgccgattc atttgtcgtt     1200

aaaggtgacg atgtgaggca gatcgctcca ggccagacag gtgtgattgc tgactataat     1260

tacaaactgc cagacgactt catggggtgc gtgctagctt ggaatacaag aaacattgac     1320

gccacctcca cgggaaatta caattacaag tatcgttacc ttcgccatgg aaagttgaga     1380

cccttcgagc gtgatataag taacgtgccc tttagtccag atggaaaacc ctgcacaccc     1440

cctgctctca attgctattg gcctctcaat gactacggct tttacacaac tactggcatc     1500

ggataccagc cttaccgggt cgtggtgctc agttttgagt tgcttaacgc acccgccacc     1560

gtgtgtggtc ctaaactttc tactgacctg attaaaaacc aatgcgtcaa cttcaatttt     1620

aacgggctga ccggcaccgg tgtcctgacc cctagctcta agagattcca gccttttcag     1680

cagttcggga gggatgtgag cgactttacc gactctgtca gggatccaaa gaccagcgag     1740

atactggata tctcgccctg cagtttcggt ggcgtgtccg ttattacacc tggcaccaac     1800

gcctcctcag aggtggcggt gctctatcaa gatgtcaact gcactgatgt gtcaactgcc     1860

atccatgccg atcagctgac ccccgcctgg cgcatctaca gtaccgggaa caacgttttt     1920

cagacccagg ccggctgtct aatcggcgca gagcacgttg acacatccta cgaatgtgac     1980

atacctatcg gggcaggcat ttgcgctagc taccataccg tgtcactgtt ggcttccacg     2040

tcacaaaagt caatcgttgc ctacacgatg agtctggggg ctgactcatc tatcgcctac     2100

agcaacaata ccattgcaat tcccacaaac ttcagtatct ccatcacaac agaggtgatg     2160

cccgtttcta tggctaaaac atcagtcgat tgcaatatgt atatatgcgg cgatagtact     2220

gagtgcgcca atctcttgtt acagtacggc tccttttgta cccagctgaa ccgagcactg     2280

tctggaatcg ccgcagaaca ggatcgcaat acccgggaag tcttcgccca ggtgaagcag     2340

atgtacaaaa cgcccactct caagtatttc ggcggattca acttttctca gattttgcct     2400

gacccgctca agccaacaaa acgatctttt atcgaagacc ttctgtttaa caaggtcaca     2460

ctggcggatg ctgggttcat gaaacagtac ggtgaatgcc tgggggacat caatgccaga     2520

gatctgatct gcgcccagaa attcaatggc ttaacagtcc tcccacctct cttgaccgac     2580

gatatgatcg ctgcgtacac cgctgctctg gtatcgggca ccgcgactgc tggctggacc     2640

tttggtgccg gagccgcact ccagatccca ttcgccatgc agatggccta ccgcttcaac     2700

ggaatcgggg tcacccagaa cgtgctgtat gagaaccaga aacagatcgc caatcagttc     2760

aataaggcaa ttagtcagat tcaggagagt cttaccacta ccagcaccgc cctgggcaag     2820

ctgcaagatg ttgtgaacca gaatgcgcag gcattaaaca ctctggttaa acagctgagc     2880

tcaaattttg gtgcaatctc ttcagttctg aacgatatcc tgagtcggct ggatccgcca     2940

gaggctgaag tgcaaattga tcgtttgatc accgggaggc tacaatctct gcagacgtac     3000

gtgacccagc agctcatccg ggcagccgaa attcgcgcat cagccaacct cgctgcaact     3060

aagatgtctg agtgcgtgct gggccagagt aagagggtgg acttttgtgg taagggatac     3120

cacctcatgt cctttccgca agcggctccc cacggcgtgg ttttcttaca cgttacctat     3180

gtgccatccc aagaacgcaa tttcaccacc gctccagcta tctgtcatga gggcaaagca     3240

tatttcccca gggaaggagt atttgtgttt aatggcacgt cctggtttat aacccaacgt     3300

aactttttct ccccacagat tatcacaacc gacaacacat tcgtgtctgg gaattgtgac     3360

gtcgtgatcg ggatcattaa caataccgtt tacgatccct tgcagcccga gcttgactcc     3420

tttaaagagg aactagacaa atactttaag aatcacacct caccggacgt agatttggga     3480

gacatctctg gaattaatgc ctctgtggtg aatatccaga aggagatcga ccgcctgaat     3540

gaagtcgcca agaacctcaa cgagtccctg atagatctgc aagaactggg caaatatgaa     3600

cagtacatca aatggccgtg gtacgtgtgg ttgggcttta tcgctggact tattgcaatc     3660

gtgatggtga cgattctgct ctgctgtatg acttcctgct gctcttgtct gaagggcgcc     3720

tgtagctgtg gttcctgctg caagttcgac gaagacgact ccgaaccagt tctgaagggg     3780

gtgaaactcc attataccta a                                               3801


<210>  89
<211>  3741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 H5iTMCT-DNA

<400>  89
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtccgatct ggatcggtgc actacatttg acgatgtgca ggcacctaat      120

tatactcagc acacctcttc catgcggggc gtgtactacc ccgacgagat ttttagaagt      180

gacacactgt acctgaccca agaccttttt ctcccatttt atagcaatgt cacgggattc      240

cacactatca atcacacatt cggaaaccct gttatcccct ttaaagacgg tatctacttt      300

gctgctactg agaaatcgaa tgttgttcgc ggttgggtgt tcggctcaac catgaacaac      360

aagagtcagt cagtaataat tataaacaac tcaaccaatg tcgtcatcag ggcttgcaac      420

ttcgagctct gcgataaccc cttctttgcg gtgtccaaac cgatgggcac tcagacccat      480

accatgattt ttgacaatgc ctttaattgt actttcgaat acatcagcga tgccttctcg      540

ctggatgtgt ccgagaagag cggtaacttc aagcatttgc gggagttcgt tttcaaaaac      600

aaagacgggt ttttgtatgt ctacaaaggc tatcagccca ttgatgtggt cagggatctg      660

cccagtggtt tcaacacact gaagcccatc ttcaagttgc cactcggcat caacatcact      720

aatttccgcg ccatcctaac tgctttttcg ccagcgcagg atatttgggg gacatccgcc      780

gcagcttact tcgtgggata tctgaagccc accactttta tgctaaagta cgacgagaat      840

ggcaccatca ccgatgccgt ggactgctca cagaatcctc tcgcagagct caagtgttca      900

gtgaagtcat ttgagatcga caaagggatc taccaaacat ctaactttcg cgtcgtgcct      960

tccggtgacg tagtccgttt cccaaatatc actaacttgt gcccttttgg tgaagtattc     1020

aacgcaacca aattccccag tgtgtatgcg tgggagcgca aaaagatcag taactgtgtg     1080

gctgactata gtgttctgta caatagcacc ttcttcagca ccttcaagtg ttatggagtg     1140

agcgctacaa aactgaacga tctttgtttc tcaaacgtgt acgccgattc atttgtcgtt     1200

aaaggtgacg atgtgaggca gatcgctcca ggccagacag gtgtgattgc tgactataat     1260

tacaaactgc cagacgactt catggggtgc gtgctagctt ggaatacaag aaacattgac     1320

gccacctcca cgggaaatta caattacaag tatcgttacc ttcgccatgg aaagttgaga     1380

cccttcgagc gtgatataag taacgtgccc tttagtccag atggaaaacc ctgcacaccc     1440

cctgctctca attgctattg gcctctcaat gactacggct tttacacaac tactggcatc     1500

ggataccagc cttaccgggt cgtggtgctc agttttgagt tgcttaacgc acccgccacc     1560

gtgtgtggtc ctaaactttc tactgacctg attaaaaacc aatgcgtcaa cttcaatttt     1620

aacgggctga ccggcaccgg tgtcctgacc cctagctcta agagattcca gccttttcag     1680

cagttcggga gggatgtgag cgactttacc gactctgtca gggatccaaa gaccagcgag     1740

atactggata tctcgccctg cagtttcggt ggcgtgtccg ttattacacc tggcaccaac     1800

gcctcctcag aggtggcggt gctctatcaa gatgtcaact gcactgatgt gtcaactgcc     1860

atccatgccg atcagctgac ccccgcctgg cgcatctaca gtaccgggaa caacgttttt     1920

cagacccagg ccggctgtct aatcggcgca gagcacgttg acacatccta cgaatgtgac     1980

atacctatcg gggcaggcat ttgcgctagc taccataccg tgtcactgtt ggcttccacg     2040

tcacaaaagt caatcgttgc ctacacgatg agtctggggg ctgactcatc tatcgcctac     2100

agcaacaata ccattgcaat tcccacaaac ttcagtatct ccatcacaac agaggtgatg     2160

cccgtttcta tggctaaaac atcagtcgat tgcaatatgt atatatgcgg cgatagtact     2220

gagtgcgcca atctcttgtt acagtacggc tccttttgta cccagctgaa ccgagcactg     2280

tctggaatcg ccgcagaaca ggatcgcaat acccgggaag tcttcgccca ggtgaagcag     2340

atgtacaaaa cgcccactct caagtatttc ggcggattca acttttctca gattttgcct     2400

gacccgctca agccaacaaa acgatctttt atcgaagacc ttctgtttaa caaggtcaca     2460

ctggcggatg ctgggttcat gaaacagtac ggtgaatgcc tgggggacat caatgccaga     2520

gatctgatct gcgcccagaa attcaatggc ttaacagtcc tcccacctct cttgaccgac     2580

gatatgatcg ctgcgtacac cgctgctctg gtatcgggca ccgcgactgc tggctggacc     2640

tttggtgccg gagccgcact ccagatccca ttcgccatgc agatggccta ccgcttcaac     2700

ggaatcgggg tcacccagaa cgtgctgtat gagaaccaga aacagatcgc caatcagttc     2760

aataaggcaa ttagtcagat tcaggagagt cttaccacta ccagcaccgc cctgggcaag     2820

ctgcaagatg ttgtgaacca gaatgcgcag gcattaaaca ctctggttaa acagctgagc     2880

tcaaattttg gtgcaatctc ttcagttctg aacgatatcc tgagtcggct ggatccgcca     2940

gaggctgaag tgcaaattga tcgtttgatc accgggaggc tacaatctct gcagacgtac     3000

gtgacccagc agctcatccg ggcagccgaa attcgcgcat cagccaacct cgctgcaact     3060

aagatgtctg agtgcgtgct gggccagagt aagagggtgg acttttgtgg taagggatac     3120

cacctcatgt cctttccgca agcggctccc cacggcgtgg ttttcttaca cgttacctat     3180

gtgccatccc aagaacgcaa tttcaccacc gctccagcta tctgtcatga gggcaaagca     3240

tatttcccca gggaaggagt atttgtgttt aatggcacgt cctggtttat aacccaacgt     3300

aactttttct ccccacagat tatcacaacc gacaacacat tcgtgtctgg gaattgtgac     3360

gtcgtgatcg ggatcattaa caataccgtt tacgatccct tgcagcccga gcttgactcc     3420

tttaaagagg aactagacaa atactttaag aatcacacct caccggacgt agatttggga     3480

gacatctctg gaattaatgc ctctgtggtg aatatccaga aggagatcga ccgcctgaat     3540

gaagtcgcca agaacctcaa cgagtccctg atagatctgc aagaactggg caaatatgaa     3600

cagtacatca aatggccgtg gtaccaaata ctgtcaattt attcaacagt ggcgagttcc     3660

ctagcactgg caatcatgat ggctggtcta tctttatgga tgtgctccaa tggatcgtta     3720

caatgcagaa tttgcattta a                                               3741


<210>  90
<211>  3732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 H5iCT-DNA

<400>  90
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtccgatct ggatcggtgc actacatttg acgatgtgca ggcacctaat      120

tatactcagc acacctcttc catgcggggc gtgtactacc ccgacgagat ttttagaagt      180

gacacactgt acctgaccca agaccttttt ctcccatttt atagcaatgt cacgggattc      240

cacactatca atcacacatt cggaaaccct gttatcccct ttaaagacgg tatctacttt      300

gctgctactg agaaatcgaa tgttgttcgc ggttgggtgt tcggctcaac catgaacaac      360

aagagtcagt cagtaataat tataaacaac tcaaccaatg tcgtcatcag ggcttgcaac      420

ttcgagctct gcgataaccc cttctttgcg gtgtccaaac cgatgggcac tcagacccat      480

accatgattt ttgacaatgc ctttaattgt actttcgaat acatcagcga tgccttctcg      540

ctggatgtgt ccgagaagag cggtaacttc aagcatttgc gggagttcgt tttcaaaaac      600

aaagacgggt ttttgtatgt ctacaaaggc tatcagccca ttgatgtggt cagggatctg      660

cccagtggtt tcaacacact gaagcccatc ttcaagttgc cactcggcat caacatcact      720

aatttccgcg ccatcctaac tgctttttcg ccagcgcagg atatttgggg gacatccgcc      780

gcagcttact tcgtgggata tctgaagccc accactttta tgctaaagta cgacgagaat      840

ggcaccatca ccgatgccgt ggactgctca cagaatcctc tcgcagagct caagtgttca      900

gtgaagtcat ttgagatcga caaagggatc taccaaacat ctaactttcg cgtcgtgcct      960

tccggtgacg tagtccgttt cccaaatatc actaacttgt gcccttttgg tgaagtattc     1020

aacgcaacca aattccccag tgtgtatgcg tgggagcgca aaaagatcag taactgtgtg     1080

gctgactata gtgttctgta caatagcacc ttcttcagca ccttcaagtg ttatggagtg     1140

agcgctacaa aactgaacga tctttgtttc tcaaacgtgt acgccgattc atttgtcgtt     1200

aaaggtgacg atgtgaggca gatcgctcca ggccagacag gtgtgattgc tgactataat     1260

tacaaactgc cagacgactt catggggtgc gtgctagctt ggaatacaag aaacattgac     1320

gccacctcca cgggaaatta caattacaag tatcgttacc ttcgccatgg aaagttgaga     1380

cccttcgagc gtgatataag taacgtgccc tttagtccag atggaaaacc ctgcacaccc     1440

cctgctctca attgctattg gcctctcaat gactacggct tttacacaac tactggcatc     1500

ggataccagc cttaccgggt cgtggtgctc agttttgagt tgcttaacgc acccgccacc     1560

gtgtgtggtc ctaaactttc tactgacctg attaaaaacc aatgcgtcaa cttcaatttt     1620

aacgggctga ccggcaccgg tgtcctgacc cctagctcta agagattcca gccttttcag     1680

cagttcggga gggatgtgag cgactttacc gactctgtca gggatccaaa gaccagcgag     1740

atactggata tctcgccctg cagtttcggt ggcgtgtccg ttattacacc tggcaccaac     1800

gcctcctcag aggtggcggt gctctatcaa gatgtcaact gcactgatgt gtcaactgcc     1860

atccatgccg atcagctgac ccccgcctgg cgcatctaca gtaccgggaa caacgttttt     1920

cagacccagg ccggctgtct aatcggcgca gagcacgttg acacatccta cgaatgtgac     1980

atacctatcg gggcaggcat ttgcgctagc taccataccg tgtcactgtt ggcttccacg     2040

tcacaaaagt caatcgttgc ctacacgatg agtctggggg ctgactcatc tatcgcctac     2100

agcaacaata ccattgcaat tcccacaaac ttcagtatct ccatcacaac agaggtgatg     2160

cccgtttcta tggctaaaac atcagtcgat tgcaatatgt atatatgcgg cgatagtact     2220

gagtgcgcca atctcttgtt acagtacggc tccttttgta cccagctgaa ccgagcactg     2280

tctggaatcg ccgcagaaca ggatcgcaat acccgggaag tcttcgccca ggtgaagcag     2340

atgtacaaaa cgcccactct caagtatttc ggcggattca acttttctca gattttgcct     2400

gacccgctca agccaacaaa acgatctttt atcgaagacc ttctgtttaa caaggtcaca     2460

ctggcggatg ctgggttcat gaaacagtac ggtgaatgcc tgggggacat caatgccaga     2520

gatctgatct gcgcccagaa attcaatggc ttaacagtcc tcccacctct cttgaccgac     2580

gatatgatcg ctgcgtacac cgctgctctg gtatcgggca ccgcgactgc tggctggacc     2640

tttggtgccg gagccgcact ccagatccca ttcgccatgc agatggccta ccgcttcaac     2700

ggaatcgggg tcacccagaa cgtgctgtat gagaaccaga aacagatcgc caatcagttc     2760

aataaggcaa ttagtcagat tcaggagagt cttaccacta ccagcaccgc cctgggcaag     2820

ctgcaagatg ttgtgaacca gaatgcgcag gcattaaaca ctctggttaa acagctgagc     2880

tcaaattttg gtgcaatctc ttcagttctg aacgatatcc tgagtcggct ggatccgcca     2940

gaggctgaag tgcaaattga tcgtttgatc accgggaggc tacaatctct gcagacgtac     3000

gtgacccagc agctcatccg ggcagccgaa attcgcgcat cagccaacct cgctgcaact     3060

aagatgtctg agtgcgtgct gggccagagt aagagggtgg acttttgtgg taagggatac     3120

cacctcatgt cctttccgca agcggctccc cacggcgtgg ttttcttaca cgttacctat     3180

gtgccatccc aagaacgcaa tttcaccacc gctccagcta tctgtcatga gggcaaagca     3240

tatttcccca gggaaggagt atttgtgttt aatggcacgt cctggtttat aacccaacgt     3300

aactttttct ccccacagat tatcacaacc gacaacacat tcgtgtctgg gaattgtgac     3360

gtcgtgatcg ggatcattaa caataccgtt tacgatccct tgcagcccga gcttgactcc     3420

tttaaagagg aactagacaa atactttaag aatcacacct caccggacgt agatttggga     3480

gacatctctg gaattaatgc ctctgtggtg aatatccaga aggagatcga ccgcctgaat     3540

gaagtcgcca agaacctcaa cgagtccctg atagatctgc aagaactggg caaatatgaa     3600

cagtacatca aatggccgtg gtacgtgtgg ttgggcttta tcgctggact tattgcaatc     3660

gtgatggtga cgattctgct ctctttatgg atgtgctcca atggatcgtt acaatgcaga     3720

atttgcattt aa                                                         3732


<210>  91
<211>  3723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 H5iCT(V4)-DNA

<400>  91
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtccgatct ggatcggtgc actacatttg acgatgtgca ggcacctaat      120

tatactcagc acacctcttc catgcggggc gtgtactacc ccgacgagat ttttagaagt      180

gacacactgt acctgaccca agaccttttt ctcccatttt atagcaatgt cacgggattc      240

cacactatca atcacacatt cggaaaccct gttatcccct ttaaagacgg tatctacttt      300

gctgctactg agaaatcgaa tgttgttcgc ggttgggtgt tcggctcaac catgaacaac      360

aagagtcagt cagtaataat tataaacaac tcaaccaatg tcgtcatcag ggcttgcaac      420

ttcgagctct gcgataaccc cttctttgcg gtgtccaaac cgatgggcac tcagacccat      480

accatgattt ttgacaatgc ctttaattgt actttcgaat acatcagcga tgccttctcg      540

ctggatgtgt ccgagaagag cggtaacttc aagcatttgc gggagttcgt tttcaaaaac      600

aaagacgggt ttttgtatgt ctacaaaggc tatcagccca ttgatgtggt cagggatctg      660

cccagtggtt tcaacacact gaagcccatc ttcaagttgc cactcggcat caacatcact      720

aatttccgcg ccatcctaac tgctttttcg ccagcgcagg atatttgggg gacatccgcc      780

gcagcttact tcgtgggata tctgaagccc accactttta tgctaaagta cgacgagaat      840

ggcaccatca ccgatgccgt ggactgctca cagaatcctc tcgcagagct caagtgttca      900

gtgaagtcat ttgagatcga caaagggatc taccaaacat ctaactttcg cgtcgtgcct      960

tccggtgacg tagtccgttt cccaaatatc actaacttgt gcccttttgg tgaagtattc     1020

aacgcaacca aattccccag tgtgtatgcg tgggagcgca aaaagatcag taactgtgtg     1080

gctgactata gtgttctgta caatagcacc ttcttcagca ccttcaagtg ttatggagtg     1140

agcgctacaa aactgaacga tctttgtttc tcaaacgtgt acgccgattc atttgtcgtt     1200

aaaggtgacg atgtgaggca gatcgctcca ggccagacag gtgtgattgc tgactataat     1260

tacaaactgc cagacgactt catggggtgc gtgctagctt ggaatacaag aaacattgac     1320

gccacctcca cgggaaatta caattacaag tatcgttacc ttcgccatgg aaagttgaga     1380

cccttcgagc gtgatataag taacgtgccc tttagtccag atggaaaacc ctgcacaccc     1440

cctgctctca attgctattg gcctctcaat gactacggct tttacacaac tactggcatc     1500

ggataccagc cttaccgggt cgtggtgctc agttttgagt tgcttaacgc acccgccacc     1560

gtgtgtggtc ctaaactttc tactgacctg attaaaaacc aatgcgtcaa cttcaatttt     1620

aacgggctga ccggcaccgg tgtcctgacc cctagctcta agagattcca gccttttcag     1680

cagttcggga gggatgtgag cgactttacc gactctgtca gggatccaaa gaccagcgag     1740

atactggata tctcgccctg cagtttcggt ggcgtgtccg ttattacacc tggcaccaac     1800

gcctcctcag aggtggcggt gctctatcaa gatgtcaact gcactgatgt gtcaactgcc     1860

atccatgccg atcagctgac ccccgcctgg cgcatctaca gtaccgggaa caacgttttt     1920

cagacccagg ccggctgtct aatcggcgca gagcacgttg acacatccta cgaatgtgac     1980

atacctatcg gggcaggcat ttgcgctagc taccataccg tgtcactgtt ggcttccacg     2040

tcacaaaagt caatcgttgc ctacacgatg agtctggggg ctgactcatc tatcgcctac     2100

agcaacaata ccattgcaat tcccacaaac ttcagtatct ccatcacaac agaggtgatg     2160

cccgtttcta tggctaaaac atcagtcgat tgcaatatgt atatatgcgg cgatagtact     2220

gagtgcgcca atctcttgtt acagtacggc tccttttgta cccagctgaa ccgagcactg     2280

tctggaatcg ccgcagaaca ggatcgcaat acccgggaag tcttcgccca ggtgaagcag     2340

atgtacaaaa cgcccactct caagtatttc ggcggattca acttttctca gattttgcct     2400

gacccgctca agccaacaaa acgatctttt atcgaagacc ttctgtttaa caaggtcaca     2460

ctggcggatg ctgggttcat gaaacagtac ggtgaatgcc tgggggacat caatgccaga     2520

gatctgatct gcgcccagaa attcaatggc ttaacagtcc tcccacctct cttgaccgac     2580

gatatgatcg ctgcgtacac cgctgctctg gtatcgggca ccgcgactgc tggctggacc     2640

tttggtgccg gagccgcact ccagatccca ttcgccatgc agatggccta ccgcttcaac     2700

ggaatcgggg tcacccagaa cgtgctgtat gagaaccaga aacagatcgc caatcagttc     2760

aataaggcaa ttagtcagat tcaggagagt cttaccacta ccagcaccgc cctgggcaag     2820

ctgcaagatg ttgtgaacca gaatgcgcag gcattaaaca ctctggttaa acagctgagc     2880

tcaaattttg gtgcaatctc ttcagttctg aacgatatcc tgagtcggct ggatccgcca     2940

gaggctgaag tgcaaattga tcgtttgatc accgggaggc tacaatctct gcagacgtac     3000

gtgacccagc agctcatccg ggcagccgaa attcgcgcat cagccaacct cgctgcaact     3060

aagatgtctg agtgcgtgct gggccagagt aagagggtgg acttttgtgg taagggatac     3120

cacctcatgt cctttccgca agcggctccc cacggcgtgg ttttcttaca cgttacctat     3180

gtgccatccc aagaacgcaa tttcaccacc gctccagcta tctgtcatga gggcaaagca     3240

tatttcccca gggaaggagt atttgtgttt aatggcacgt cctggtttat aacccaacgt     3300

aactttttct ccccacagat tatcacaacc gacaacacat tcgtgtctgg gaattgtgac     3360

gtcgtgatcg ggatcattaa caataccgtt tacgatccct tgcagcccga gcttgactcc     3420

tttaaagagg aactagacaa atactttaag aatcacacct caccggacgt agatttggga     3480

gacatctctg gaattaatgc ctctgtggtg aatatccaga aggagatcga ccgcctgaat     3540

gaagtcgcca agaacctcaa cgagtccctg atagatctgc aagaactggg caaatatgaa     3600

cagtacatca aatggccgtg gtacgtgtgg ttgggcttta tcgctggact tattgcaatc     3660

gtgatggtga cgattctgct ctgctgctcc aatggatcgt tacaatgcag aatttgcatt     3720

taa                                                                   3723


<210>  92
<211>  3732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 H1cCT-DNA

<400>  92
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtccgatct ggatcggtgc actacatttg acgatgtgca ggcacctaat      120

tatactcagc acacctcttc catgcggggc gtgtactacc ccgacgagat ttttagaagt      180

gacacactgt acctgaccca agaccttttt ctcccatttt atagcaatgt cacgggattc      240

cacactatca atcacacatt cggaaaccct gttatcccct ttaaagacgg tatctacttt      300

gctgctactg agaaatcgaa tgttgttcgc ggttgggtgt tcggctcaac catgaacaac      360

aagagtcagt cagtaataat tataaacaac tcaaccaatg tcgtcatcag ggcttgcaac      420

ttcgagctct gcgataaccc cttctttgcg gtgtccaaac cgatgggcac tcagacccat      480

accatgattt ttgacaatgc ctttaattgt actttcgaat acatcagcga tgccttctcg      540

ctggatgtgt ccgagaagag cggtaacttc aagcatttgc gggagttcgt tttcaaaaac      600

aaagacgggt ttttgtatgt ctacaaaggc tatcagccca ttgatgtggt cagggatctg      660

cccagtggtt tcaacacact gaagcccatc ttcaagttgc cactcggcat caacatcact      720

aatttccgcg ccatcctaac tgctttttcg ccagcgcagg atatttgggg gacatccgcc      780

gcagcttact tcgtgggata tctgaagccc accactttta tgctaaagta cgacgagaat      840

ggcaccatca ccgatgccgt ggactgctca cagaatcctc tcgcagagct caagtgttca      900

gtgaagtcat ttgagatcga caaagggatc taccaaacat ctaactttcg cgtcgtgcct      960

tccggtgacg tagtccgttt cccaaatatc actaacttgt gcccttttgg tgaagtattc     1020

aacgcaacca aattccccag tgtgtatgcg tgggagcgca aaaagatcag taactgtgtg     1080

gctgactata gtgttctgta caatagcacc ttcttcagca ccttcaagtg ttatggagtg     1140

agcgctacaa aactgaacga tctttgtttc tcaaacgtgt acgccgattc atttgtcgtt     1200

aaaggtgacg atgtgaggca gatcgctcca ggccagacag gtgtgattgc tgactataat     1260

tacaaactgc cagacgactt catggggtgc gtgctagctt ggaatacaag aaacattgac     1320

gccacctcca cgggaaatta caattacaag tatcgttacc ttcgccatgg aaagttgaga     1380

cccttcgagc gtgatataag taacgtgccc tttagtccag atggaaaacc ctgcacaccc     1440

cctgctctca attgctattg gcctctcaat gactacggct tttacacaac tactggcatc     1500

ggataccagc cttaccgggt cgtggtgctc agttttgagt tgcttaacgc acccgccacc     1560

gtgtgtggtc ctaaactttc tactgacctg attaaaaacc aatgcgtcaa cttcaatttt     1620

aacgggctga ccggcaccgg tgtcctgacc cctagctcta agagattcca gccttttcag     1680

cagttcggga gggatgtgag cgactttacc gactctgtca gggatccaaa gaccagcgag     1740

atactggata tctcgccctg cagtttcggt ggcgtgtccg ttattacacc tggcaccaac     1800

gcctcctcag aggtggcggt gctctatcaa gatgtcaact gcactgatgt gtcaactgcc     1860

atccatgccg atcagctgac ccccgcctgg cgcatctaca gtaccgggaa caacgttttt     1920

cagacccagg ccggctgtct aatcggcgca gagcacgttg acacatccta cgaatgtgac     1980

atacctatcg gggcaggcat ttgcgctagc taccataccg tgtcactgtt ggcttccacg     2040

tcacaaaagt caatcgttgc ctacacgatg agtctggggg ctgactcatc tatcgcctac     2100

agcaacaata ccattgcaat tcccacaaac ttcagtatct ccatcacaac agaggtgatg     2160

cccgtttcta tggctaaaac atcagtcgat tgcaatatgt atatatgcgg cgatagtact     2220

gagtgcgcca atctcttgtt acagtacggc tccttttgta cccagctgaa ccgagcactg     2280

tctggaatcg ccgcagaaca ggatcgcaat acccgggaag tcttcgccca ggtgaagcag     2340

atgtacaaaa cgcccactct caagtatttc ggcggattca acttttctca gattttgcct     2400

gacccgctca agccaacaaa acgatctttt atcgaagacc ttctgtttaa caaggtcaca     2460

ctggcggatg ctgggttcat gaaacagtac ggtgaatgcc tgggggacat caatgccaga     2520

gatctgatct gcgcccagaa attcaatggc ttaacagtcc tcccacctct cttgaccgac     2580

gatatgatcg ctgcgtacac cgctgctctg gtatcgggca ccgcgactgc tggctggacc     2640

tttggtgccg gagccgcact ccagatccca ttcgccatgc agatggccta ccgcttcaac     2700

ggaatcgggg tcacccagaa cgtgctgtat gagaaccaga aacagatcgc caatcagttc     2760

aataaggcaa ttagtcagat tcaggagagt cttaccacta ccagcaccgc cctgggcaag     2820

ctgcaagatg ttgtgaacca gaatgcgcag gcattaaaca ctctggttaa acagctgagc     2880

tcaaattttg gtgcaatctc ttcagttctg aacgatatcc tgagtcggct ggatccgcca     2940

gaggctgaag tgcaaattga tcgtttgatc accgggaggc tacaatctct gcagacgtac     3000

gtgacccagc agctcatccg ggcagccgaa attcgcgcat cagccaacct cgctgcaact     3060

aagatgtctg agtgcgtgct gggccagagt aagagggtgg acttttgtgg taagggatac     3120

cacctcatgt cctttccgca agcggctccc cacggcgtgg ttttcttaca cgttacctat     3180

gtgccatccc aagaacgcaa tttcaccacc gctccagcta tctgtcatga gggcaaagca     3240

tatttcccca gggaaggagt atttgtgttt aatggcacgt cctggtttat aacccaacgt     3300

aactttttct ccccacagat tatcacaacc gacaacacat tcgtgtctgg gaattgtgac     3360

gtcgtgatcg ggatcattaa caataccgtt tacgatccct tgcagcccga gcttgactcc     3420

tttaaagagg aactagacaa atactttaag aatcacacct caccggacgt agatttggga     3480

gacatctctg gaattaatgc ctctgtggtg aatatccaga aggagatcga ccgcctgaat     3540

gaagtcgcca agaacctcaa cgagtccctg atagatctgc aagaactggg caaatatgaa     3600

cagtacatca aatggccgtg gtacgtgtgg ttgggcttta tcgctggact tattgcaatc     3660

gtgatggtga cgattctgct cagcttctgg atgtgctcta atgggtctct acagtgtaga     3720

atatgtattt aa                                                         3732


<210>  93
<211>  1266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 wtTMCT-AA

<400>  93

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Ser Asp Leu Asp Arg Cys Thr Thr 
            20                  25                  30          


Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln His Thr Ser Ser Met 
        35                  40                  45              


Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg Ser Asp Thr Leu Tyr 
    50                  55                  60                  


Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser Asn Val Thr Gly Phe 
65                  70                  75                  80  


His Thr Ile Asn His Thr Phe Gly Asn Pro Val Ile Pro Phe Lys Asp 
                85                  90                  95      


Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val Val Arg Gly Trp 
            100                 105                 110         


Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln Ser Val Ile Ile Ile 
        115                 120                 125             


Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys Asn Phe Glu Leu Cys 
    130                 135                 140                 


Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met Gly Thr Gln Thr His 
145                 150                 155                 160 


Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr Phe Glu Tyr Ile Ser 
                165                 170                 175     


Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser Gly Asn Phe Lys His 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly Phe Leu Tyr Val Tyr 
        195                 200                 205             


Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp Leu Pro Ser Gly Phe 
    210                 215                 220                 


Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro Ala Gln Asp Ile Trp 
                245                 250                 255     


Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr Leu Lys Pro Thr Thr 
            260                 265                 270         


Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys Ser Val Lys Ser Phe 
    290                 295                 300                 


Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Val Pro 
305                 310                 315                 320 


Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu 
            340                 345                 350         


Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val 
385                 390                 395                 400 


Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu 
            420                 425                 430         


Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro 
465                 470                 475                 480 


Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr 
                485                 490                 495     


Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr 
        515                 520                 525             


Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg Phe Gln Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp Ser Val Arg Asp Pro 
                565                 570                 575     


Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser Glu Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr Gly Asn Asn Val Phe 
625                 630                 635                 640 


Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asp Thr Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr His 
            660                 665                 670         


Thr Val Ser Leu Leu Ala Ser Thr Ser Gln Lys Ser Ile Val Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala Tyr Ser Asn Asn Thr 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile Thr Thr Glu Val Met 
705                 710                 715                 720 


Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys Asn Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile Ala Ala Glu Gln Asp 
        755                 760                 765             


Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys Gln Met Tyr Lys Thr 
    770                 775                 780                 


Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met Lys Gln Tyr Gly Glu 
            820                 825                 830         


Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile Ala 
    850                 855                 860                 


Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala Ile Ser Gln Ile Gln 
        915                 920                 925             


Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ala Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ser Gln Glu  Arg Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Glu Gly Lys Ala  Tyr Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Phe  Asn Gly Thr Ser Trp  Phe Ile Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Phe Ser Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Ile Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Val Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Leu Leu Cys Cys Met  Thr Ser Cys 
    1220                 1225                 1230             


Cys Ser  Cys Leu Lys Gly Ala  Cys Ser Cys Gly Ser  Cys Cys Lys 
    1235                 1240                 1245             


Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu 
    1250                 1255                 1260             


His Tyr  Thr 
    1265     


<210>  94
<211>  1246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 H5iTMCT-AA

<400>  94

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Ser Asp Leu Asp Arg Cys Thr Thr 
            20                  25                  30          


Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln His Thr Ser Ser Met 
        35                  40                  45              


Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg Ser Asp Thr Leu Tyr 
    50                  55                  60                  


Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser Asn Val Thr Gly Phe 
65                  70                  75                  80  


His Thr Ile Asn His Thr Phe Gly Asn Pro Val Ile Pro Phe Lys Asp 
                85                  90                  95      


Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val Val Arg Gly Trp 
            100                 105                 110         


Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln Ser Val Ile Ile Ile 
        115                 120                 125             


Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys Asn Phe Glu Leu Cys 
    130                 135                 140                 


Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met Gly Thr Gln Thr His 
145                 150                 155                 160 


Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr Phe Glu Tyr Ile Ser 
                165                 170                 175     


Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser Gly Asn Phe Lys His 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly Phe Leu Tyr Val Tyr 
        195                 200                 205             


Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp Leu Pro Ser Gly Phe 
    210                 215                 220                 


Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro Ala Gln Asp Ile Trp 
                245                 250                 255     


Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr Leu Lys Pro Thr Thr 
            260                 265                 270         


Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys Ser Val Lys Ser Phe 
    290                 295                 300                 


Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Val Pro 
305                 310                 315                 320 


Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu 
            340                 345                 350         


Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val 
385                 390                 395                 400 


Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu 
            420                 425                 430         


Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro 
465                 470                 475                 480 


Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr 
                485                 490                 495     


Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr 
        515                 520                 525             


Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg Phe Gln Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp Ser Val Arg Asp Pro 
                565                 570                 575     


Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser Glu Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr Gly Asn Asn Val Phe 
625                 630                 635                 640 


Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asp Thr Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr His 
            660                 665                 670         


Thr Val Ser Leu Leu Ala Ser Thr Ser Gln Lys Ser Ile Val Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala Tyr Ser Asn Asn Thr 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile Thr Thr Glu Val Met 
705                 710                 715                 720 


Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys Asn Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile Ala Ala Glu Gln Asp 
        755                 760                 765             


Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys Gln Met Tyr Lys Thr 
    770                 775                 780                 


Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met Lys Gln Tyr Gly Glu 
            820                 825                 830         


Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile Ala 
    850                 855                 860                 


Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala Ile Ser Gln Ile Gln 
        915                 920                 925             


Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ala Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ser Gln Glu  Arg Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Glu Gly Lys Ala  Tyr Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Phe  Asn Gly Thr Ser Trp  Phe Ile Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Phe Ser Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Ile Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Gln Ile  Leu Ser Ile Tyr Ser  Thr Val Ala 
    1205                 1210                 1215             


Ser Ser  Leu Ala Leu Ala Ile  Met Met Ala Gly Leu  Ser Leu Trp 
    1220                 1225                 1230             


Met Cys  Ser Asn Gly Ser Leu  Gln Cys Arg Ile Cys  Ile 
    1235                 1240                 1245     


<210>  95
<211>  1243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 H5iCT-AA

<400>  95

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Ser Asp Leu Asp Arg Cys Thr Thr 
            20                  25                  30          


Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln His Thr Ser Ser Met 
        35                  40                  45              


Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg Ser Asp Thr Leu Tyr 
    50                  55                  60                  


Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser Asn Val Thr Gly Phe 
65                  70                  75                  80  


His Thr Ile Asn His Thr Phe Gly Asn Pro Val Ile Pro Phe Lys Asp 
                85                  90                  95      


Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val Val Arg Gly Trp 
            100                 105                 110         


Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln Ser Val Ile Ile Ile 
        115                 120                 125             


Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys Asn Phe Glu Leu Cys 
    130                 135                 140                 


Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met Gly Thr Gln Thr His 
145                 150                 155                 160 


Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr Phe Glu Tyr Ile Ser 
                165                 170                 175     


Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser Gly Asn Phe Lys His 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly Phe Leu Tyr Val Tyr 
        195                 200                 205             


Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp Leu Pro Ser Gly Phe 
    210                 215                 220                 


Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro Ala Gln Asp Ile Trp 
                245                 250                 255     


Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr Leu Lys Pro Thr Thr 
            260                 265                 270         


Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys Ser Val Lys Ser Phe 
    290                 295                 300                 


Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Val Pro 
305                 310                 315                 320 


Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu 
            340                 345                 350         


Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val 
385                 390                 395                 400 


Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu 
            420                 425                 430         


Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro 
465                 470                 475                 480 


Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr 
                485                 490                 495     


Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr 
        515                 520                 525             


Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg Phe Gln Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp Ser Val Arg Asp Pro 
                565                 570                 575     


Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser Glu Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr Gly Asn Asn Val Phe 
625                 630                 635                 640 


Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asp Thr Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr His 
            660                 665                 670         


Thr Val Ser Leu Leu Ala Ser Thr Ser Gln Lys Ser Ile Val Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala Tyr Ser Asn Asn Thr 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile Thr Thr Glu Val Met 
705                 710                 715                 720 


Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys Asn Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile Ala Ala Glu Gln Asp 
        755                 760                 765             


Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys Gln Met Tyr Lys Thr 
    770                 775                 780                 


Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met Lys Gln Tyr Gly Glu 
            820                 825                 830         


Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile Ala 
    850                 855                 860                 


Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala Ile Ser Gln Ile Gln 
        915                 920                 925             


Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ala Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ser Gln Glu  Arg Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Glu Gly Lys Ala  Tyr Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Phe  Asn Gly Thr Ser Trp  Phe Ile Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Phe Ser Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Ile Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Val Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Leu Leu Ser Leu Trp  Met Cys Ser 
    1220                 1225                 1230             


Asn Gly  Ser Leu Gln Cys Arg  Ile Cys Ile 
    1235                 1240             


<210>  96
<211>  1240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 H5iCT(V4)-AA

<400>  96

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Ser Asp Leu Asp Arg Cys Thr Thr 
            20                  25                  30          


Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln His Thr Ser Ser Met 
        35                  40                  45              


Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg Ser Asp Thr Leu Tyr 
    50                  55                  60                  


Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser Asn Val Thr Gly Phe 
65                  70                  75                  80  


His Thr Ile Asn His Thr Phe Gly Asn Pro Val Ile Pro Phe Lys Asp 
                85                  90                  95      


Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val Val Arg Gly Trp 
            100                 105                 110         


Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln Ser Val Ile Ile Ile 
        115                 120                 125             


Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys Asn Phe Glu Leu Cys 
    130                 135                 140                 


Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met Gly Thr Gln Thr His 
145                 150                 155                 160 


Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr Phe Glu Tyr Ile Ser 
                165                 170                 175     


Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser Gly Asn Phe Lys His 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly Phe Leu Tyr Val Tyr 
        195                 200                 205             


Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp Leu Pro Ser Gly Phe 
    210                 215                 220                 


Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro Ala Gln Asp Ile Trp 
                245                 250                 255     


Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr Leu Lys Pro Thr Thr 
            260                 265                 270         


Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys Ser Val Lys Ser Phe 
    290                 295                 300                 


Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Val Pro 
305                 310                 315                 320 


Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu 
            340                 345                 350         


Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val 
385                 390                 395                 400 


Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu 
            420                 425                 430         


Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro 
465                 470                 475                 480 


Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr 
                485                 490                 495     


Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr 
        515                 520                 525             


Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg Phe Gln Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp Ser Val Arg Asp Pro 
                565                 570                 575     


Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser Glu Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr Gly Asn Asn Val Phe 
625                 630                 635                 640 


Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asp Thr Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr His 
            660                 665                 670         


Thr Val Ser Leu Leu Ala Ser Thr Ser Gln Lys Ser Ile Val Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala Tyr Ser Asn Asn Thr 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile Thr Thr Glu Val Met 
705                 710                 715                 720 


Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys Asn Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile Ala Ala Glu Gln Asp 
        755                 760                 765             


Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys Gln Met Tyr Lys Thr 
    770                 775                 780                 


Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met Lys Gln Tyr Gly Glu 
            820                 825                 830         


Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile Ala 
    850                 855                 860                 


Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala Ile Ser Gln Ile Gln 
        915                 920                 925             


Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ala Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ser Gln Glu  Arg Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Glu Gly Lys Ala  Tyr Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Phe  Asn Gly Thr Ser Trp  Phe Ile Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Phe Ser Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Ile Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Val Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Leu Leu Cys Cys Ser  Asn Gly Ser 
    1220                 1225                 1230             


Leu Gln  Cys Arg Ile Cys Ile  
    1235                 1240 


<210>  97
<211>  1243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-SARS-COV-1 H1cCT-AA

<400>  97

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Ser Asp Leu Asp Arg Cys Thr Thr 
            20                  25                  30          


Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln His Thr Ser Ser Met 
        35                  40                  45              


Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg Ser Asp Thr Leu Tyr 
    50                  55                  60                  


Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser Asn Val Thr Gly Phe 
65                  70                  75                  80  


His Thr Ile Asn His Thr Phe Gly Asn Pro Val Ile Pro Phe Lys Asp 
                85                  90                  95      


Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val Val Arg Gly Trp 
            100                 105                 110         


Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln Ser Val Ile Ile Ile 
        115                 120                 125             


Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys Asn Phe Glu Leu Cys 
    130                 135                 140                 


Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met Gly Thr Gln Thr His 
145                 150                 155                 160 


Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr Phe Glu Tyr Ile Ser 
                165                 170                 175     


Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser Gly Asn Phe Lys His 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly Phe Leu Tyr Val Tyr 
        195                 200                 205             


Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp Leu Pro Ser Gly Phe 
    210                 215                 220                 


Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro Ala Gln Asp Ile Trp 
                245                 250                 255     


Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr Leu Lys Pro Thr Thr 
            260                 265                 270         


Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys Ser Val Lys Ser Phe 
    290                 295                 300                 


Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Val Pro 
305                 310                 315                 320 


Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu 
            340                 345                 350         


Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val 
385                 390                 395                 400 


Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu 
            420                 425                 430         


Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro 
465                 470                 475                 480 


Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr 
                485                 490                 495     


Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr 
        515                 520                 525             


Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg Phe Gln Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp Ser Val Arg Asp Pro 
                565                 570                 575     


Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser Glu Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr Gly Asn Asn Val Phe 
625                 630                 635                 640 


Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asp Thr Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr His 
            660                 665                 670         


Thr Val Ser Leu Leu Ala Ser Thr Ser Gln Lys Ser Ile Val Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala Tyr Ser Asn Asn Thr 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile Thr Thr Glu Val Met 
705                 710                 715                 720 


Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys Asn Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile Ala Ala Glu Gln Asp 
        755                 760                 765             


Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys Gln Met Tyr Lys Thr 
    770                 775                 780                 


Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met Lys Gln Tyr Gly Glu 
            820                 825                 830         


Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile Ala 
    850                 855                 860                 


Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala Ile Ser Gln Ile Gln 
        915                 920                 925             


Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ala Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ser Gln Glu  Arg Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Glu Gly Lys Ala  Tyr Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Phe  Asn Gly Thr Ser Trp  Phe Ile Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Phe Ser Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Ile Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Val Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Leu Leu Ser Phe Trp  Met Cys Ser 
    1220                 1225                 1230             


Asn Gly  Ser Leu Gln Cys Arg  Ile Cys Ile 
    1235                 1240             


<210>  98
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(AvB+wtCT-MERS).r

<400>  98
acgacacgac taaggccttc agtgaacgtg gaccttgtga ggctcaaggt catactcctc       60


<210>  99
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(H1cCT-wtTM).r

<400>  99
acgacacgac taaggccttc aaatacatat tctacactgt agagaccca                   49


<210>  100
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(H5ITMCT).r

<400>  100
acgacacgac taaggccttc aaatgcaaat tctgcattgt aacgatcc                    48


<210>  101
<211>  4083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-wtTMCT-DNA

<400>  101
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtatgtcga tgtgggtccc gatagtgtta agtccgcctg catcgaagtg      120

gacattcagc agaccttctt cgataagact tggcctcggc caattgatgt gtccaaggcc      180

gacggcatta tctaccccca aggtcggaca tattccaaca taactatcac ctatcagggg      240

ctattccctt atcagggcga ccatggggac atgtacgttt acagcgctgg tcacgctaca      300

gggacgaccc cccagaagct cttcgtggcg aactatagtc aggacgtgaa acagtttgcc      360

aacggttttg tagtgcgcat cggggcagcc gctaactcca ctggtactgt tattatcagc      420

ccttccacga gtgccacaat tcgaaagatc tatccggcct tcatgctagg atcctctgtg      480

ggcaatttta gcgacggtaa gatgggtcgg ttcttcaacc acacgcttgt gctgcttccc      540

gatgggtgcg gtactttgct gagggccttt tactgtatcc tagagccccg atccggcaac      600

cactgccccg ccgggaactc gtatacttcc tttgccactt atcatactcc agccacggat      660

tgtagcgatg ggaactacaa taggaacgcc agtttgaatt cctttaaaga gtacttcaac      720

ttgcggaatt gtaccttcat gtatacatat aacattactg aggacgaaat tctcgaatgg      780

ttcggaatca ctcaaacagc ccagggagtg cacctcttta gttctcgcta tgtggactta      840

tatggaggca atatgtttca attcgccacc ttacccgtct acgatacgat caagtattac      900

tcgatcatac cccactccat taggtccatt cagagcgatc gcaaggcatg ggccgcattc      960

tatgtgtata agctccagcc cctgaccttc ctcttggatt tctccgtgga cggctacatc     1020

agaagggcta tcgattgcgg gttcaacgac ctcagccagc tgcattgttc ttatgagagc     1080

tttgacgtgg aaagcggagt ttactcagtc tcttcctttg aggctaaacc ttcaggtagc     1140

gtcgtagagc aagcagaggg tgtggagtgc gatttctcac cactgctcag cggaacccca     1200

ccccaggtct acaactttaa gcggctcgtg ttcacaaact gtaactataa cttgactaag     1260

ttgctgtcac tcttttccgt gaatgatttt acatgctccc aaatcagccc agccgctatt     1320

gcgtctaatt gctattcctc attgatcctg gattacttca gttaccccct ctctatgaag     1380

agcgatctct cggttagtag cgctgggcct atttcccagt ttaactacaa acaatccttt     1440

tccaatccaa catgcctgat cttagctact gtaccccaca acctgactac tattacgaag     1500

ccactcaagt actcatacat taataagtgc agccgattcc tcagtgatga tcgcaccgaa     1560

gtgccgcagc ttgtaaacgc gaaccagtac tccccatgcg tctctattgt gccttctaca     1620

gtgtgggaag acggcgatta ttatagaaag cagctgtcgc cactggaagg tggcgggtgg     1680

ctagttgcca gtgggtccac agttgccatg accgagcaac ttcagatggg gtttggcata     1740

acagtgcagt atggtaccga tacgaacagc gtgtgtccaa aattggaatt tgctaacgac     1800

accaagatcg cctcccagtt gggaaattgt gttgaatatt ccctgtacgg agtgtcaggc     1860

cggggggtgt tccaaaattg caccgccgtg ggagtgaggc agcaaagatt cgtgtacgac     1920

gcataccaga atctagtcgg atactattct gacgatggaa actactactg tctgcgcgct     1980

tgcgtctcag tgcccgtgag tgtcatatat gataaggaga ccaagactca cgctactctc     2040

tttggttctg tcgcgtgcga acacatttcc tctacaatgt cccagtatag tcgctccact     2100

cggtctatgt taaagcgcag agacagtacc tacggccctc tacagacacc tgtggggtgc     2160

gttctcggcc ttgtcaattc tagcctgttt gtggaggatt gtaagctgcc ccttggtcaa     2220

agcttatgcg cactgcccga tacgcccagc acacttacac cagcttcagt ggggtccgtc     2280

cccggggaaa tgagattggc ctcgatcgct ttcaaccacc ccatacaggt ggatcagctc     2340

aactcgtcat acttcaagct aagcatccct actaatttct cctttggtgt gactcaggag     2400

tacattcaga ccacaattca aaaggtgacc gttgactgca agcagtatgt gtgcaacggg     2460

ttccagaaat gtgaacagct gctccgggag tatggccagt tctgttctaa aatcaaccag     2520

gccctccacg gagcaaacct taggcaggac gattctgtca gaaacctctt tgccagcgtc     2580

aagagttctc agagttcccc tattatacct ggcttcggcg gggatttcaa cctgacacta     2640

cttgaacctg taagcatatc aaccggaagt cgcagtgccc gttccgccat cgaggatctg     2700

ctcttcgaca aagtaactat tgcagatccc ggatacatgc aggggtatga cgactgcatg     2760

cagcagggtc cagcctctgc aagggatctg atatgcgcac agtatgtcgc tgggtacaaa     2820

gtgttgcctc ctctcatgga cgtgaacatg gaagcggcct atacctcctc acttctaggc     2880

tccatagcgg gcgtgggatg gaccgcaggg ctttcaagct tcgccgcaat tccctttgct     2940

caatctatct tctacaggct taatggcgtt ggaatcaccc agcaggtgtt aagcgaaaac     3000

cagaaattga ttgccaataa gtttaaccaa gctttggggg ccatgcagac aggctttaca     3060

accacaaacg aggctttcca taaagtacag gatgcggtaa acaataacgc acaagccctg     3120

tcaaagctgg cttcagagct ctcaaataca tttggcgcta tatccgcgtc tatcggcgat     3180

atcatacaac ggttggaccc acccgaacag gacgcacaga ttgatcgttt gatcaacggg     3240

aggcttacca ccttaaacgc ttttgtggcc cagcaactgg tgcggtctga gagcgccgcc     3300

ttgagcgctc agctggcaaa ggataaagtg aatgaatgcg tgaaagctca atcaaagaga     3360

agtgggtttt gtgggcaggg tactcatatt gtttcctttg tggtgaacgc cccaaatgga     3420

ctctacttta tgcatgttgg atactacccg agcaaccaca tcgaggtcgt ttccgcctat     3480

gggctttgtg acgcagcaaa ccctactaac tgtatcgcgc cagttaatgg ctactttatt     3540

aaaacaaata acacacgcat tgtggatgaa tggagttaca cagggtccag cttctacgct     3600

ccagagccta tcacctctct gaacacaaag tatgtggcac ctcaggtcac atatcagaac     3660

atctcgacaa acctgccccc cccactcttg ggcaactcca cagggatcga cttccaggac     3720

gagcttgacg aattcttcaa gaacgtgtcc accagtatcc ctaattttgg ttcgctgacc     3780

caaattaaca caaccctgct cgatctgaca tatgaaatgc tttcactaca gcaggtggtc     3840

aaagcgttga acgagtcgta tatcgacctg aaagagttag ggaattacac atactataac     3900

aaatggccct ggtatatttg gttaggattc attgccgggc tggtggccct tgccttgtgc     3960

gtatttttca tcttgtgctg taccggttgc ggtacgaatt gcatgggaaa actgaaatgt     4020

aatcggtgct gcgatcgcta tgaggagtat gaccttgagc ctcacaaggt ccacgttcac     4080

tga                                                                   4083


<210>  102
<211>  4032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-H5iTMCT-DNA

<400>  102
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtatgtcga tgtgggtccc gatagtgtta agtccgcctg catcgaagtg      120

gacattcagc agaccttctt cgataagact tggcctcggc caattgatgt gtccaaggcc      180

gacggcatta tctaccccca aggtcggaca tattccaaca taactatcac ctatcagggg      240

ctattccctt atcagggcga ccatggggac atgtacgttt acagcgctgg tcacgctaca      300

gggacgaccc cccagaagct cttcgtggcg aactatagtc aggacgtgaa acagtttgcc      360

aacggttttg tagtgcgcat cggggcagcc gctaactcca ctggtactgt tattatcagc      420

ccttccacga gtgccacaat tcgaaagatc tatccggcct tcatgctagg atcctctgtg      480

ggcaatttta gcgacggtaa gatgggtcgg ttcttcaacc acacgcttgt gctgcttccc      540

gatgggtgcg gtactttgct gagggccttt tactgtatcc tagagccccg atccggcaac      600

cactgccccg ccgggaactc gtatacttcc tttgccactt atcatactcc agccacggat      660

tgtagcgatg ggaactacaa taggaacgcc agtttgaatt cctttaaaga gtacttcaac      720

ttgcggaatt gtaccttcat gtatacatat aacattactg aggacgaaat tctcgaatgg      780

ttcggaatca ctcaaacagc ccagggagtg cacctcttta gttctcgcta tgtggactta      840

tatggaggca atatgtttca attcgccacc ttacccgtct acgatacgat caagtattac      900

tcgatcatac cccactccat taggtccatt cagagcgatc gcaaggcatg ggccgcattc      960

tatgtgtata agctccagcc cctgaccttc ctcttggatt tctccgtgga cggctacatc     1020

agaagggcta tcgattgcgg gttcaacgac ctcagccagc tgcattgttc ttatgagagc     1080

tttgacgtgg aaagcggagt ttactcagtc tcttcctttg aggctaaacc ttcaggtagc     1140

gtcgtagagc aagcagaggg tgtggagtgc gatttctcac cactgctcag cggaacccca     1200

ccccaggtct acaactttaa gcggctcgtg ttcacaaact gtaactataa cttgactaag     1260

ttgctgtcac tcttttccgt gaatgatttt acatgctccc aaatcagccc agccgctatt     1320

gcgtctaatt gctattcctc attgatcctg gattacttca gttaccccct ctctatgaag     1380

agcgatctct cggttagtag cgctgggcct atttcccagt ttaactacaa acaatccttt     1440

tccaatccaa catgcctgat cttagctact gtaccccaca acctgactac tattacgaag     1500

ccactcaagt actcatacat taataagtgc agccgattcc tcagtgatga tcgcaccgaa     1560

gtgccgcagc ttgtaaacgc gaaccagtac tccccatgcg tctctattgt gccttctaca     1620

gtgtgggaag acggcgatta ttatagaaag cagctgtcgc cactggaagg tggcgggtgg     1680

ctagttgcca gtgggtccac agttgccatg accgagcaac ttcagatggg gtttggcata     1740

acagtgcagt atggtaccga tacgaacagc gtgtgtccaa aattggaatt tgctaacgac     1800

accaagatcg cctcccagtt gggaaattgt gttgaatatt ccctgtacgg agtgtcaggc     1860

cggggggtgt tccaaaattg caccgccgtg ggagtgaggc agcaaagatt cgtgtacgac     1920

gcataccaga atctagtcgg atactattct gacgatggaa actactactg tctgcgcgct     1980

tgcgtctcag tgcccgtgag tgtcatatat gataaggaga ccaagactca cgctactctc     2040

tttggttctg tcgcgtgcga acacatttcc tctacaatgt cccagtatag tcgctccact     2100

cggtctatgt taaagcgcag agacagtacc tacggccctc tacagacacc tgtggggtgc     2160

gttctcggcc ttgtcaattc tagcctgttt gtggaggatt gtaagctgcc ccttggtcaa     2220

agcttatgcg cactgcccga tacgcccagc acacttacac cagcttcagt ggggtccgtc     2280

cccggggaaa tgagattggc ctcgatcgct ttcaaccacc ccatacaggt ggatcagctc     2340

aactcgtcat acttcaagct aagcatccct actaatttct cctttggtgt gactcaggag     2400

tacattcaga ccacaattca aaaggtgacc gttgactgca agcagtatgt gtgcaacggg     2460

ttccagaaat gtgaacagct gctccgggag tatggccagt tctgttctaa aatcaaccag     2520

gccctccacg gagcaaacct taggcaggac gattctgtca gaaacctctt tgccagcgtc     2580

aagagttctc agagttcccc tattatacct ggcttcggcg gggatttcaa cctgacacta     2640

cttgaacctg taagcatatc aaccggaagt cgcagtgccc gttccgccat cgaggatctg     2700

ctcttcgaca aagtaactat tgcagatccc ggatacatgc aggggtatga cgactgcatg     2760

cagcagggtc cagcctctgc aagggatctg atatgcgcac agtatgtcgc tgggtacaaa     2820

gtgttgcctc ctctcatgga cgtgaacatg gaagcggcct atacctcctc acttctaggc     2880

tccatagcgg gcgtgggatg gaccgcaggg ctttcaagct tcgccgcaat tccctttgct     2940

caatctatct tctacaggct taatggcgtt ggaatcaccc agcaggtgtt aagcgaaaac     3000

cagaaattga ttgccaataa gtttaaccaa gctttggggg ccatgcagac aggctttaca     3060

accacaaacg aggctttcca taaagtacag gatgcggtaa acaataacgc acaagccctg     3120

tcaaagctgg cttcagagct ctcaaataca tttggcgcta tatccgcgtc tatcggcgat     3180

atcatacaac ggttggaccc acccgaacag gacgcacaga ttgatcgttt gatcaacggg     3240

aggcttacca ccttaaacgc ttttgtggcc cagcaactgg tgcggtctga gagcgccgcc     3300

ttgagcgctc agctggcaaa ggataaagtg aatgaatgcg tgaaagctca atcaaagaga     3360

agtgggtttt gtgggcaggg tactcatatt gtttcctttg tggtgaacgc cccaaatgga     3420

ctctacttta tgcatgttgg atactacccg agcaaccaca tcgaggtcgt ttccgcctat     3480

gggctttgtg acgcagcaaa ccctactaac tgtatcgcgc cagttaatgg ctactttatt     3540

aaaacaaata acacacgcat tgtggatgaa tggagttaca cagggtccag cttctacgct     3600

ccagagccta tcacctctct gaacacaaag tatgtggcac ctcaggtcac atatcagaac     3660

atctcgacaa acctgccccc cccactcttg ggcaactcca cagggatcga cttccaggac     3720

gagcttgacg aattcttcaa gaacgtgtcc accagtatcc ctaattttgg ttcgctgacc     3780

caaattaaca caaccctgct cgatctgaca tatgaaatgc tttcactaca gcaggtggtc     3840

aaagcgttga acgagtcgta tatcgacctg aaagagttag ggaattacac atactataac     3900

aaatggccct ggtatcaaat actgtcaatt tattcaacag tggcgagttc cctagcactg     3960

gcaatcatga tggctggtct atctttatgg atgtgctcca atggatcgtt acaatgcaga     4020

atttgcattt ga                                                         4032


<210>  103
<211>  4026
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-H5iCT-DNA

<400>  103
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtatgtcga tgtgggtccc gatagtgtta agtccgcctg catcgaagtg      120

gacattcagc agaccttctt cgataagact tggcctcggc caattgatgt gtccaaggcc      180

gacggcatta tctaccccca aggtcggaca tattccaaca taactatcac ctatcagggg      240

ctattccctt atcagggcga ccatggggac atgtacgttt acagcgctgg tcacgctaca      300

gggacgaccc cccagaagct cttcgtggcg aactatagtc aggacgtgaa acagtttgcc      360

aacggttttg tagtgcgcat cggggcagcc gctaactcca ctggtactgt tattatcagc      420

ccttccacga gtgccacaat tcgaaagatc tatccggcct tcatgctagg atcctctgtg      480

ggcaatttta gcgacggtaa gatgggtcgg ttcttcaacc acacgcttgt gctgcttccc      540

gatgggtgcg gtactttgct gagggccttt tactgtatcc tagagccccg atccggcaac      600

cactgccccg ccgggaactc gtatacttcc tttgccactt atcatactcc agccacggat      660

tgtagcgatg ggaactacaa taggaacgcc agtttgaatt cctttaaaga gtacttcaac      720

ttgcggaatt gtaccttcat gtatacatat aacattactg aggacgaaat tctcgaatgg      780

ttcggaatca ctcaaacagc ccagggagtg cacctcttta gttctcgcta tgtggactta      840

tatggaggca atatgtttca attcgccacc ttacccgtct acgatacgat caagtattac      900

tcgatcatac cccactccat taggtccatt cagagcgatc gcaaggcatg ggccgcattc      960

tatgtgtata agctccagcc cctgaccttc ctcttggatt tctccgtgga cggctacatc     1020

agaagggcta tcgattgcgg gttcaacgac ctcagccagc tgcattgttc ttatgagagc     1080

tttgacgtgg aaagcggagt ttactcagtc tcttcctttg aggctaaacc ttcaggtagc     1140

gtcgtagagc aagcagaggg tgtggagtgc gatttctcac cactgctcag cggaacccca     1200

ccccaggtct acaactttaa gcggctcgtg ttcacaaact gtaactataa cttgactaag     1260

ttgctgtcac tcttttccgt gaatgatttt acatgctccc aaatcagccc agccgctatt     1320

gcgtctaatt gctattcctc attgatcctg gattacttca gttaccccct ctctatgaag     1380

agcgatctct cggttagtag cgctgggcct atttcccagt ttaactacaa acaatccttt     1440

tccaatccaa catgcctgat cttagctact gtaccccaca acctgactac tattacgaag     1500

ccactcaagt actcatacat taataagtgc agccgattcc tcagtgatga tcgcaccgaa     1560

gtgccgcagc ttgtaaacgc gaaccagtac tccccatgcg tctctattgt gccttctaca     1620

gtgtgggaag acggcgatta ttatagaaag cagctgtcgc cactggaagg tggcgggtgg     1680

ctagttgcca gtgggtccac agttgccatg accgagcaac ttcagatggg gtttggcata     1740

acagtgcagt atggtaccga tacgaacagc gtgtgtccaa aattggaatt tgctaacgac     1800

accaagatcg cctcccagtt gggaaattgt gttgaatatt ccctgtacgg agtgtcaggc     1860

cggggggtgt tccaaaattg caccgccgtg ggagtgaggc agcaaagatt cgtgtacgac     1920

gcataccaga atctagtcgg atactattct gacgatggaa actactactg tctgcgcgct     1980

tgcgtctcag tgcccgtgag tgtcatatat gataaggaga ccaagactca cgctactctc     2040

tttggttctg tcgcgtgcga acacatttcc tctacaatgt cccagtatag tcgctccact     2100

cggtctatgt taaagcgcag agacagtacc tacggccctc tacagacacc tgtggggtgc     2160

gttctcggcc ttgtcaattc tagcctgttt gtggaggatt gtaagctgcc ccttggtcaa     2220

agcttatgcg cactgcccga tacgcccagc acacttacac cagcttcagt ggggtccgtc     2280

cccggggaaa tgagattggc ctcgatcgct ttcaaccacc ccatacaggt ggatcagctc     2340

aactcgtcat acttcaagct aagcatccct actaatttct cctttggtgt gactcaggag     2400

tacattcaga ccacaattca aaaggtgacc gttgactgca agcagtatgt gtgcaacggg     2460

ttccagaaat gtgaacagct gctccgggag tatggccagt tctgttctaa aatcaaccag     2520

gccctccacg gagcaaacct taggcaggac gattctgtca gaaacctctt tgccagcgtc     2580

aagagttctc agagttcccc tattatacct ggcttcggcg gggatttcaa cctgacacta     2640

cttgaacctg taagcatatc aaccggaagt cgcagtgccc gttccgccat cgaggatctg     2700

ctcttcgaca aagtaactat tgcagatccc ggatacatgc aggggtatga cgactgcatg     2760

cagcagggtc cagcctctgc aagggatctg atatgcgcac agtatgtcgc tgggtacaaa     2820

gtgttgcctc ctctcatgga cgtgaacatg gaagcggcct atacctcctc acttctaggc     2880

tccatagcgg gcgtgggatg gaccgcaggg ctttcaagct tcgccgcaat tccctttgct     2940

caatctatct tctacaggct taatggcgtt ggaatcaccc agcaggtgtt aagcgaaaac     3000

cagaaattga ttgccaataa gtttaaccaa gctttggggg ccatgcagac aggctttaca     3060

accacaaacg aggctttcca taaagtacag gatgcggtaa acaataacgc acaagccctg     3120

tcaaagctgg cttcagagct ctcaaataca tttggcgcta tatccgcgtc tatcggcgat     3180

atcatacaac ggttggaccc acccgaacag gacgcacaga ttgatcgttt gatcaacggg     3240

aggcttacca ccttaaacgc ttttgtggcc cagcaactgg tgcggtctga gagcgccgcc     3300

ttgagcgctc agctggcaaa ggataaagtg aatgaatgcg tgaaagctca atcaaagaga     3360

agtgggtttt gtgggcaggg tactcatatt gtttcctttg tggtgaacgc cccaaatgga     3420

ctctacttta tgcatgttgg atactacccg agcaaccaca tcgaggtcgt ttccgcctat     3480

gggctttgtg acgcagcaaa ccctactaac tgtatcgcgc cagttaatgg ctactttatt     3540

aaaacaaata acacacgcat tgtggatgaa tggagttaca cagggtccag cttctacgct     3600

ccagagccta tcacctctct gaacacaaag tatgtggcac ctcaggtcac atatcagaac     3660

atctcgacaa acctgccccc cccactcttg ggcaactcca cagggatcga cttccaggac     3720

gagcttgacg aattcttcaa gaacgtgtcc accagtatcc ctaattttgg ttcgctgacc     3780

caaattaaca caaccctgct cgatctgaca tatgaaatgc tttcactaca gcaggtggtc     3840

aaagcgttga acgagtcgta tatcgacctg aaagagttag ggaattacac atactataac     3900

aaatggccct ggtatatttg gttaggattc attgccgggc tggtggccct tgccttgtgc     3960

gtatttttca tcttgtcttt atggatgtgc tccaatggat cgttacaatg cagaatttgc     4020

atttga                                                                4026


<210>  104
<211>  4017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-H5iCT(V4)-DNA

<400>  104
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtatgtcga tgtgggtccc gatagtgtta agtccgcctg catcgaagtg      120

gacattcagc agaccttctt cgataagact tggcctcggc caattgatgt gtccaaggcc      180

gacggcatta tctaccccca aggtcggaca tattccaaca taactatcac ctatcagggg      240

ctattccctt atcagggcga ccatggggac atgtacgttt acagcgctgg tcacgctaca      300

gggacgaccc cccagaagct cttcgtggcg aactatagtc aggacgtgaa acagtttgcc      360

aacggttttg tagtgcgcat cggggcagcc gctaactcca ctggtactgt tattatcagc      420

ccttccacga gtgccacaat tcgaaagatc tatccggcct tcatgctagg atcctctgtg      480

ggcaatttta gcgacggtaa gatgggtcgg ttcttcaacc acacgcttgt gctgcttccc      540

gatgggtgcg gtactttgct gagggccttt tactgtatcc tagagccccg atccggcaac      600

cactgccccg ccgggaactc gtatacttcc tttgccactt atcatactcc agccacggat      660

tgtagcgatg ggaactacaa taggaacgcc agtttgaatt cctttaaaga gtacttcaac      720

ttgcggaatt gtaccttcat gtatacatat aacattactg aggacgaaat tctcgaatgg      780

ttcggaatca ctcaaacagc ccagggagtg cacctcttta gttctcgcta tgtggactta      840

tatggaggca atatgtttca attcgccacc ttacccgtct acgatacgat caagtattac      900

tcgatcatac cccactccat taggtccatt cagagcgatc gcaaggcatg ggccgcattc      960

tatgtgtata agctccagcc cctgaccttc ctcttggatt tctccgtgga cggctacatc     1020

agaagggcta tcgattgcgg gttcaacgac ctcagccagc tgcattgttc ttatgagagc     1080

tttgacgtgg aaagcggagt ttactcagtc tcttcctttg aggctaaacc ttcaggtagc     1140

gtcgtagagc aagcagaggg tgtggagtgc gatttctcac cactgctcag cggaacccca     1200

ccccaggtct acaactttaa gcggctcgtg ttcacaaact gtaactataa cttgactaag     1260

ttgctgtcac tcttttccgt gaatgatttt acatgctccc aaatcagccc agccgctatt     1320

gcgtctaatt gctattcctc attgatcctg gattacttca gttaccccct ctctatgaag     1380

agcgatctct cggttagtag cgctgggcct atttcccagt ttaactacaa acaatccttt     1440

tccaatccaa catgcctgat cttagctact gtaccccaca acctgactac tattacgaag     1500

ccactcaagt actcatacat taataagtgc agccgattcc tcagtgatga tcgcaccgaa     1560

gtgccgcagc ttgtaaacgc gaaccagtac tccccatgcg tctctattgt gccttctaca     1620

gtgtgggaag acggcgatta ttatagaaag cagctgtcgc cactggaagg tggcgggtgg     1680

ctagttgcca gtgggtccac agttgccatg accgagcaac ttcagatggg gtttggcata     1740

acagtgcagt atggtaccga tacgaacagc gtgtgtccaa aattggaatt tgctaacgac     1800

accaagatcg cctcccagtt gggaaattgt gttgaatatt ccctgtacgg agtgtcaggc     1860

cggggggtgt tccaaaattg caccgccgtg ggagtgaggc agcaaagatt cgtgtacgac     1920

gcataccaga atctagtcgg atactattct gacgatggaa actactactg tctgcgcgct     1980

tgcgtctcag tgcccgtgag tgtcatatat gataaggaga ccaagactca cgctactctc     2040

tttggttctg tcgcgtgcga acacatttcc tctacaatgt cccagtatag tcgctccact     2100

cggtctatgt taaagcgcag agacagtacc tacggccctc tacagacacc tgtggggtgc     2160

gttctcggcc ttgtcaattc tagcctgttt gtggaggatt gtaagctgcc ccttggtcaa     2220

agcttatgcg cactgcccga tacgcccagc acacttacac cagcttcagt ggggtccgtc     2280

cccggggaaa tgagattggc ctcgatcgct ttcaaccacc ccatacaggt ggatcagctc     2340

aactcgtcat acttcaagct aagcatccct actaatttct cctttggtgt gactcaggag     2400

tacattcaga ccacaattca aaaggtgacc gttgactgca agcagtatgt gtgcaacggg     2460

ttccagaaat gtgaacagct gctccgggag tatggccagt tctgttctaa aatcaaccag     2520

gccctccacg gagcaaacct taggcaggac gattctgtca gaaacctctt tgccagcgtc     2580

aagagttctc agagttcccc tattatacct ggcttcggcg gggatttcaa cctgacacta     2640

cttgaacctg taagcatatc aaccggaagt cgcagtgccc gttccgccat cgaggatctg     2700

ctcttcgaca aagtaactat tgcagatccc ggatacatgc aggggtatga cgactgcatg     2760

cagcagggtc cagcctctgc aagggatctg atatgcgcac agtatgtcgc tgggtacaaa     2820

gtgttgcctc ctctcatgga cgtgaacatg gaagcggcct atacctcctc acttctaggc     2880

tccatagcgg gcgtgggatg gaccgcaggg ctttcaagct tcgccgcaat tccctttgct     2940

caatctatct tctacaggct taatggcgtt ggaatcaccc agcaggtgtt aagcgaaaac     3000

cagaaattga ttgccaataa gtttaaccaa gctttggggg ccatgcagac aggctttaca     3060

accacaaacg aggctttcca taaagtacag gatgcggtaa acaataacgc acaagccctg     3120

tcaaagctgg cttcagagct ctcaaataca tttggcgcta tatccgcgtc tatcggcgat     3180

atcatacaac ggttggaccc acccgaacag gacgcacaga ttgatcgttt gatcaacggg     3240

aggcttacca ccttaaacgc ttttgtggcc cagcaactgg tgcggtctga gagcgccgcc     3300

ttgagcgctc agctggcaaa ggataaagtg aatgaatgcg tgaaagctca atcaaagaga     3360

agtgggtttt gtgggcaggg tactcatatt gtttcctttg tggtgaacgc cccaaatgga     3420

ctctacttta tgcatgttgg atactacccg agcaaccaca tcgaggtcgt ttccgcctat     3480

gggctttgtg acgcagcaaa ccctactaac tgtatcgcgc cagttaatgg ctactttatt     3540

aaaacaaata acacacgcat tgtggatgaa tggagttaca cagggtccag cttctacgct     3600

ccagagccta tcacctctct gaacacaaag tatgtggcac ctcaggtcac atatcagaac     3660

atctcgacaa acctgccccc cccactcttg ggcaactcca cagggatcga cttccaggac     3720

gagcttgacg aattcttcaa gaacgtgtcc accagtatcc ctaattttgg ttcgctgacc     3780

caaattaaca caaccctgct cgatctgaca tatgaaatgc tttcactaca gcaggtggtc     3840

aaagcgttga acgagtcgta tatcgacctg aaagagttag ggaattacac atactataac     3900

aaatggccct ggtatatttg gttaggattc attgccgggc tggtggccct tgccttgtgc     3960

gtatttttca tcttgtgctg ctccaatgga tcgttacaat gcagaatttg catttga        4017


<210>  105
<211>  4026
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-H1cCT-DNA

<400>  105
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgtatgtcga tgtgggtccc gatagtgtta agtccgcctg catcgaagtg      120

gacattcagc agaccttctt cgataagact tggcctcggc caattgatgt gtccaaggcc      180

gacggcatta tctaccccca aggtcggaca tattccaaca taactatcac ctatcagggg      240

ctattccctt atcagggcga ccatggggac atgtacgttt acagcgctgg tcacgctaca      300

gggacgaccc cccagaagct cttcgtggcg aactatagtc aggacgtgaa acagtttgcc      360

aacggttttg tagtgcgcat cggggcagcc gctaactcca ctggtactgt tattatcagc      420

ccttccacga gtgccacaat tcgaaagatc tatccggcct tcatgctagg atcctctgtg      480

ggcaatttta gcgacggtaa gatgggtcgg ttcttcaacc acacgcttgt gctgcttccc      540

gatgggtgcg gtactttgct gagggccttt tactgtatcc tagagccccg atccggcaac      600

cactgccccg ccgggaactc gtatacttcc tttgccactt atcatactcc agccacggat      660

tgtagcgatg ggaactacaa taggaacgcc agtttgaatt cctttaaaga gtacttcaac      720

ttgcggaatt gtaccttcat gtatacatat aacattactg aggacgaaat tctcgaatgg      780

ttcggaatca ctcaaacagc ccagggagtg cacctcttta gttctcgcta tgtggactta      840

tatggaggca atatgtttca attcgccacc ttacccgtct acgatacgat caagtattac      900

tcgatcatac cccactccat taggtccatt cagagcgatc gcaaggcatg ggccgcattc      960

tatgtgtata agctccagcc cctgaccttc ctcttggatt tctccgtgga cggctacatc     1020

agaagggcta tcgattgcgg gttcaacgac ctcagccagc tgcattgttc ttatgagagc     1080

tttgacgtgg aaagcggagt ttactcagtc tcttcctttg aggctaaacc ttcaggtagc     1140

gtcgtagagc aagcagaggg tgtggagtgc gatttctcac cactgctcag cggaacccca     1200

ccccaggtct acaactttaa gcggctcgtg ttcacaaact gtaactataa cttgactaag     1260

ttgctgtcac tcttttccgt gaatgatttt acatgctccc aaatcagccc agccgctatt     1320

gcgtctaatt gctattcctc attgatcctg gattacttca gttaccccct ctctatgaag     1380

agcgatctct cggttagtag cgctgggcct atttcccagt ttaactacaa acaatccttt     1440

tccaatccaa catgcctgat cttagctact gtaccccaca acctgactac tattacgaag     1500

ccactcaagt actcatacat taataagtgc agccgattcc tcagtgatga tcgcaccgaa     1560

gtgccgcagc ttgtaaacgc gaaccagtac tccccatgcg tctctattgt gccttctaca     1620

gtgtgggaag acggcgatta ttatagaaag cagctgtcgc cactggaagg tggcgggtgg     1680

ctagttgcca gtgggtccac agttgccatg accgagcaac ttcagatggg gtttggcata     1740

acagtgcagt atggtaccga tacgaacagc gtgtgtccaa aattggaatt tgctaacgac     1800

accaagatcg cctcccagtt gggaaattgt gttgaatatt ccctgtacgg agtgtcaggc     1860

cggggggtgt tccaaaattg caccgccgtg ggagtgaggc agcaaagatt cgtgtacgac     1920

gcataccaga atctagtcgg atactattct gacgatggaa actactactg tctgcgcgct     1980

tgcgtctcag tgcccgtgag tgtcatatat gataaggaga ccaagactca cgctactctc     2040

tttggttctg tcgcgtgcga acacatttcc tctacaatgt cccagtatag tcgctccact     2100

cggtctatgt taaagcgcag agacagtacc tacggccctc tacagacacc tgtggggtgc     2160

gttctcggcc ttgtcaattc tagcctgttt gtggaggatt gtaagctgcc ccttggtcaa     2220

agcttatgcg cactgcccga tacgcccagc acacttacac cagcttcagt ggggtccgtc     2280

cccggggaaa tgagattggc ctcgatcgct ttcaaccacc ccatacaggt ggatcagctc     2340

aactcgtcat acttcaagct aagcatccct actaatttct cctttggtgt gactcaggag     2400

tacattcaga ccacaattca aaaggtgacc gttgactgca agcagtatgt gtgcaacggg     2460

ttccagaaat gtgaacagct gctccgggag tatggccagt tctgttctaa aatcaaccag     2520

gccctccacg gagcaaacct taggcaggac gattctgtca gaaacctctt tgccagcgtc     2580

aagagttctc agagttcccc tattatacct ggcttcggcg gggatttcaa cctgacacta     2640

cttgaacctg taagcatatc aaccggaagt cgcagtgccc gttccgccat cgaggatctg     2700

ctcttcgaca aagtaactat tgcagatccc ggatacatgc aggggtatga cgactgcatg     2760

cagcagggtc cagcctctgc aagggatctg atatgcgcac agtatgtcgc tgggtacaaa     2820

gtgttgcctc ctctcatgga cgtgaacatg gaagcggcct atacctcctc acttctaggc     2880

tccatagcgg gcgtgggatg gaccgcaggg ctttcaagct tcgccgcaat tccctttgct     2940

caatctatct tctacaggct taatggcgtt ggaatcaccc agcaggtgtt aagcgaaaac     3000

cagaaattga ttgccaataa gtttaaccaa gctttggggg ccatgcagac aggctttaca     3060

accacaaacg aggctttcca taaagtacag gatgcggtaa acaataacgc acaagccctg     3120

tcaaagctgg cttcagagct ctcaaataca tttggcgcta tatccgcgtc tatcggcgat     3180

atcatacaac ggttggaccc acccgaacag gacgcacaga ttgatcgttt gatcaacggg     3240

aggcttacca ccttaaacgc ttttgtggcc cagcaactgg tgcggtctga gagcgccgcc     3300

ttgagcgctc agctggcaaa ggataaagtg aatgaatgcg tgaaagctca atcaaagaga     3360

agtgggtttt gtgggcaggg tactcatatt gtttcctttg tggtgaacgc cccaaatgga     3420

ctctacttta tgcatgttgg atactacccg agcaaccaca tcgaggtcgt ttccgcctat     3480

gggctttgtg acgcagcaaa ccctactaac tgtatcgcgc cagttaatgg ctactttatt     3540

aaaacaaata acacacgcat tgtggatgaa tggagttaca cagggtccag cttctacgct     3600

ccagagccta tcacctctct gaacacaaag tatgtggcac ctcaggtcac atatcagaac     3660

atctcgacaa acctgccccc cccactcttg ggcaactcca cagggatcga cttccaggac     3720

gagcttgacg aattcttcaa gaacgtgtcc accagtatcc ctaattttgg ttcgctgacc     3780

caaattaaca caaccctgct cgatctgaca tatgaaatgc tttcactaca gcaggtggtc     3840

aaagcgttga acgagtcgta tatcgacctg aaagagttag ggaattacac atactataac     3900

aaatggccct ggtatatttg gttaggattc attgccgggc tggtggccct tgccttgtgc     3960

gtatttttca tcttgagctt ctggatgtgc tctaatgggt ctctacagtg tagaatatgt     4020

atttga                                                                4026


<210>  106
<211>  1360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-wtTMCT-AA

<400>  106

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Tyr Val Asp Val Gly Pro Asp Ser 
            20                  25                  30          


Val Lys Ser Ala Cys Ile Glu Val Asp Ile Gln Gln Thr Phe Phe Asp 
        35                  40                  45              


Lys Thr Trp Pro Arg Pro Ile Asp Val Ser Lys Ala Asp Gly Ile Ile 
    50                  55                  60                  


Tyr Pro Gln Gly Arg Thr Tyr Ser Asn Ile Thr Ile Thr Tyr Gln Gly 
65                  70                  75                  80  


Leu Phe Pro Tyr Gln Gly Asp His Gly Asp Met Tyr Val Tyr Ser Ala 
                85                  90                  95      


Gly His Ala Thr Gly Thr Thr Pro Gln Lys Leu Phe Val Ala Asn Tyr 
            100                 105                 110         


Ser Gln Asp Val Lys Gln Phe Ala Asn Gly Phe Val Val Arg Ile Gly 
        115                 120                 125             


Ala Ala Ala Asn Ser Thr Gly Thr Val Ile Ile Ser Pro Ser Thr Ser 
    130                 135                 140                 


Ala Thr Ile Arg Lys Ile Tyr Pro Ala Phe Met Leu Gly Ser Ser Val 
145                 150                 155                 160 


Gly Asn Phe Ser Asp Gly Lys Met Gly Arg Phe Phe Asn His Thr Leu 
                165                 170                 175     


Val Leu Leu Pro Asp Gly Cys Gly Thr Leu Leu Arg Ala Phe Tyr Cys 
            180                 185                 190         


Ile Leu Glu Pro Arg Ser Gly Asn His Cys Pro Ala Gly Asn Ser Tyr 
        195                 200                 205             


Thr Ser Phe Ala Thr Tyr His Thr Pro Ala Thr Asp Cys Ser Asp Gly 
    210                 215                 220                 


Asn Tyr Asn Arg Asn Ala Ser Leu Asn Ser Phe Lys Glu Tyr Phe Asn 
225                 230                 235                 240 


Leu Arg Asn Cys Thr Phe Met Tyr Thr Tyr Asn Ile Thr Glu Asp Glu 
                245                 250                 255     


Ile Leu Glu Trp Phe Gly Ile Thr Gln Thr Ala Gln Gly Val His Leu 
            260                 265                 270         


Phe Ser Ser Arg Tyr Val Asp Leu Tyr Gly Gly Asn Met Phe Gln Phe 
        275                 280                 285             


Ala Thr Leu Pro Val Tyr Asp Thr Ile Lys Tyr Tyr Ser Ile Ile Pro 
    290                 295                 300                 


His Ser Ile Arg Ser Ile Gln Ser Asp Arg Lys Ala Trp Ala Ala Phe 
305                 310                 315                 320 


Tyr Val Tyr Lys Leu Gln Pro Leu Thr Phe Leu Leu Asp Phe Ser Val 
                325                 330                 335     


Asp Gly Tyr Ile Arg Arg Ala Ile Asp Cys Gly Phe Asn Asp Leu Ser 
            340                 345                 350         


Gln Leu His Cys Ser Tyr Glu Ser Phe Asp Val Glu Ser Gly Val Tyr 
        355                 360                 365             


Ser Val Ser Ser Phe Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln 
    370                 375                 380                 


Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro 
385                 390                 395                 400 


Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr 
                405                 410                 415     


Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys 
            420                 425                 430         


Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu 
        435                 440                 445             


Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser 
    450                 455                 460                 


Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe 
465                 470                 475                 480 


Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr 
                485                 490                 495     


Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg 
            500                 505                 510         


Phe Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn 
        515                 520                 525             


Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp 
    530                 535                 540                 


Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp 
545                 550                 555                 560 


Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met 
                565                 570                 575     


Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys 
            580                 585                 590         


Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly 
        595                 600                 605             


Asn Cys Val Glu Tyr Ser Leu Tyr Gly Val Ser Gly Arg Gly Val Phe 
    610                 615                 620                 


Gln Asn Cys Thr Ala Val Gly Val Arg Gln Gln Arg Phe Val Tyr Asp 
625                 630                 635                 640 


Ala Tyr Gln Asn Leu Val Gly Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr 
                645                 650                 655     


Cys Leu Arg Ala Cys Val Ser Val Pro Val Ser Val Ile Tyr Asp Lys 
            660                 665                 670         


Glu Thr Lys Thr His Ala Thr Leu Phe Gly Ser Val Ala Cys Glu His 
        675                 680                 685             


Ile Ser Ser Thr Met Ser Gln Tyr Ser Arg Ser Thr Arg Ser Met Leu 
    690                 695                 700                 


Lys Arg Arg Asp Ser Thr Tyr Gly Pro Leu Gln Thr Pro Val Gly Cys 
705                 710                 715                 720 


Val Leu Gly Leu Val Asn Ser Ser Leu Phe Val Glu Asp Cys Lys Leu 
                725                 730                 735     


Pro Leu Gly Gln Ser Leu Cys Ala Leu Pro Asp Thr Pro Ser Thr Leu 
            740                 745                 750         


Thr Pro Ala Ser Val Gly Ser Val Pro Gly Glu Met Arg Leu Ala Ser 
        755                 760                 765             


Ile Ala Phe Asn His Pro Ile Gln Val Asp Gln Leu Asn Ser Ser Tyr 
    770                 775                 780                 


Phe Lys Leu Ser Ile Pro Thr Asn Phe Ser Phe Gly Val Thr Gln Glu 
785                 790                 795                 800 


Tyr Ile Gln Thr Thr Ile Gln Lys Val Thr Val Asp Cys Lys Gln Tyr 
                805                 810                 815     


Val Cys Asn Gly Phe Gln Lys Cys Glu Gln Leu Leu Arg Glu Tyr Gly 
            820                 825                 830         


Gln Phe Cys Ser Lys Ile Asn Gln Ala Leu His Gly Ala Asn Leu Arg 
        835                 840                 845             


Gln Asp Asp Ser Val Arg Asn Leu Phe Ala Ser Val Lys Ser Ser Gln 
    850                 855                 860                 


Ser Ser Pro Ile Ile Pro Gly Phe Gly Gly Asp Phe Asn Leu Thr Leu 
865                 870                 875                 880 


Leu Glu Pro Val Ser Ile Ser Thr Gly Ser Arg Ser Ala Arg Ser Ala 
                885                 890                 895     


Ile Glu Asp Leu Leu Phe Asp Lys Val Thr Ile Ala Asp Pro Gly Tyr 
            900                 905                 910         


Met Gln Gly Tyr Asp Asp Cys Met Gln Gln Gly Pro Ala Ser Ala Arg 
        915                 920                 925             


Asp Leu Ile Cys Ala Gln Tyr Val Ala Gly Tyr Lys Val Leu Pro Pro 
    930                 935                 940                 


Leu Met Asp Val Asn Met Glu Ala Ala Tyr Thr Ser Ser Leu Leu Gly 
945                 950                 955                 960 


Ser Ile Ala Gly Val Gly Trp Thr Ala Gly Leu Ser Ser Phe Ala Ala 
                965                 970                 975     


Ile Pro Phe Ala Gln Ser Ile Phe Tyr Arg Leu Asn Gly Val Gly Ile 
            980                 985                 990         


Thr Gln Gln Val Leu Ser Glu Asn  Gln Lys Leu Ile Ala  Asn Lys Phe 
        995                 1000                 1005             


Asn Gln  Ala Leu Gly Ala Met  Gln Thr Gly Phe Thr  Thr Thr Asn 
    1010                 1015                 1020             


Glu Ala  Phe His Lys Val Gln  Asp Ala Val Asn Asn  Asn Ala Gln 
    1025                 1030                 1035             


Ala Leu  Ser Lys Leu Ala Ser  Glu Leu Ser Asn Thr  Phe Gly Ala 
    1040                 1045                 1050             


Ile Ser  Ala Ser Ile Gly Asp  Ile Ile Gln Arg Leu  Asp Pro Pro 
    1055                 1060                 1065             


Glu Gln  Asp Ala Gln Ile Asp  Arg Leu Ile Asn Gly  Arg Leu Thr 
    1070                 1075                 1080             


Thr Leu  Asn Ala Phe Val Ala  Gln Gln Leu Val Arg  Ser Glu Ser 
    1085                 1090                 1095             


Ala Ala  Leu Ser Ala Gln Leu  Ala Lys Asp Lys Val  Asn Glu Cys 
    1100                 1105                 1110             


Val Lys  Ala Gln Ser Lys Arg  Ser Gly Phe Cys Gly  Gln Gly Thr 
    1115                 1120                 1125             


His Ile  Val Ser Phe Val Val  Asn Ala Pro Asn Gly  Leu Tyr Phe 
    1130                 1135                 1140             


Met His  Val Gly Tyr Tyr Pro  Ser Asn His Ile Glu  Val Val Ser 
    1145                 1150                 1155             


Ala Tyr  Gly Leu Cys Asp Ala  Ala Asn Pro Thr Asn  Cys Ile Ala 
    1160                 1165                 1170             


Pro Val  Asn Gly Tyr Phe Ile  Lys Thr Asn Asn Thr  Arg Ile Val 
    1175                 1180                 1185             


Asp Glu  Trp Ser Tyr Thr Gly  Ser Ser Phe Tyr Ala  Pro Glu Pro 
    1190                 1195                 1200             


Ile Thr  Ser Leu Asn Thr Lys  Tyr Val Ala Pro Gln  Val Thr Tyr 
    1205                 1210                 1215             


Gln Asn  Ile Ser Thr Asn Leu  Pro Pro Pro Leu Leu  Gly Asn Ser 
    1220                 1225                 1230             


Thr Gly  Ile Asp Phe Gln Asp  Glu Leu Asp Glu Phe  Phe Lys Asn 
    1235                 1240                 1245             


Val Ser  Thr Ser Ile Pro Asn  Phe Gly Ser Leu Thr  Gln Ile Asn 
    1250                 1255                 1260             


Thr Thr  Leu Leu Asp Leu Thr  Tyr Glu Met Leu Ser  Leu Gln Gln 
    1265                 1270                 1275             


Val Val  Lys Ala Leu Asn Glu  Ser Tyr Ile Asp Leu  Lys Glu Leu 
    1280                 1285                 1290             


Gly Asn  Tyr Thr Tyr Tyr Asn  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1295                 1300                 1305             


Gly Phe  Ile Ala Gly Leu Val  Ala Leu Ala Leu Cys  Val Phe Phe 
    1310                 1315                 1320             


Ile Leu  Cys Cys Thr Gly Cys  Gly Thr Asn Cys Met  Gly Lys Leu 
    1325                 1330                 1335             


Lys Cys  Asn Arg Cys Cys Asp  Arg Tyr Glu Glu Tyr  Asp Leu Glu 
    1340                 1345                 1350             


Pro His  Lys Val His Val His  
    1355                 1360 


<210>  107
<211>  1343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-H5iTMCT-AA

<400>  107

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Tyr Val Asp Val Gly Pro Asp Ser 
            20                  25                  30          


Val Lys Ser Ala Cys Ile Glu Val Asp Ile Gln Gln Thr Phe Phe Asp 
        35                  40                  45              


Lys Thr Trp Pro Arg Pro Ile Asp Val Ser Lys Ala Asp Gly Ile Ile 
    50                  55                  60                  


Tyr Pro Gln Gly Arg Thr Tyr Ser Asn Ile Thr Ile Thr Tyr Gln Gly 
65                  70                  75                  80  


Leu Phe Pro Tyr Gln Gly Asp His Gly Asp Met Tyr Val Tyr Ser Ala 
                85                  90                  95      


Gly His Ala Thr Gly Thr Thr Pro Gln Lys Leu Phe Val Ala Asn Tyr 
            100                 105                 110         


Ser Gln Asp Val Lys Gln Phe Ala Asn Gly Phe Val Val Arg Ile Gly 
        115                 120                 125             


Ala Ala Ala Asn Ser Thr Gly Thr Val Ile Ile Ser Pro Ser Thr Ser 
    130                 135                 140                 


Ala Thr Ile Arg Lys Ile Tyr Pro Ala Phe Met Leu Gly Ser Ser Val 
145                 150                 155                 160 


Gly Asn Phe Ser Asp Gly Lys Met Gly Arg Phe Phe Asn His Thr Leu 
                165                 170                 175     


Val Leu Leu Pro Asp Gly Cys Gly Thr Leu Leu Arg Ala Phe Tyr Cys 
            180                 185                 190         


Ile Leu Glu Pro Arg Ser Gly Asn His Cys Pro Ala Gly Asn Ser Tyr 
        195                 200                 205             


Thr Ser Phe Ala Thr Tyr His Thr Pro Ala Thr Asp Cys Ser Asp Gly 
    210                 215                 220                 


Asn Tyr Asn Arg Asn Ala Ser Leu Asn Ser Phe Lys Glu Tyr Phe Asn 
225                 230                 235                 240 


Leu Arg Asn Cys Thr Phe Met Tyr Thr Tyr Asn Ile Thr Glu Asp Glu 
                245                 250                 255     


Ile Leu Glu Trp Phe Gly Ile Thr Gln Thr Ala Gln Gly Val His Leu 
            260                 265                 270         


Phe Ser Ser Arg Tyr Val Asp Leu Tyr Gly Gly Asn Met Phe Gln Phe 
        275                 280                 285             


Ala Thr Leu Pro Val Tyr Asp Thr Ile Lys Tyr Tyr Ser Ile Ile Pro 
    290                 295                 300                 


His Ser Ile Arg Ser Ile Gln Ser Asp Arg Lys Ala Trp Ala Ala Phe 
305                 310                 315                 320 


Tyr Val Tyr Lys Leu Gln Pro Leu Thr Phe Leu Leu Asp Phe Ser Val 
                325                 330                 335     


Asp Gly Tyr Ile Arg Arg Ala Ile Asp Cys Gly Phe Asn Asp Leu Ser 
            340                 345                 350         


Gln Leu His Cys Ser Tyr Glu Ser Phe Asp Val Glu Ser Gly Val Tyr 
        355                 360                 365             


Ser Val Ser Ser Phe Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln 
    370                 375                 380                 


Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro 
385                 390                 395                 400 


Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr 
                405                 410                 415     


Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys 
            420                 425                 430         


Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu 
        435                 440                 445             


Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser 
    450                 455                 460                 


Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe 
465                 470                 475                 480 


Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr 
                485                 490                 495     


Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg 
            500                 505                 510         


Phe Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn 
        515                 520                 525             


Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp 
    530                 535                 540                 


Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp 
545                 550                 555                 560 


Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met 
                565                 570                 575     


Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys 
            580                 585                 590         


Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly 
        595                 600                 605             


Asn Cys Val Glu Tyr Ser Leu Tyr Gly Val Ser Gly Arg Gly Val Phe 
    610                 615                 620                 


Gln Asn Cys Thr Ala Val Gly Val Arg Gln Gln Arg Phe Val Tyr Asp 
625                 630                 635                 640 


Ala Tyr Gln Asn Leu Val Gly Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr 
                645                 650                 655     


Cys Leu Arg Ala Cys Val Ser Val Pro Val Ser Val Ile Tyr Asp Lys 
            660                 665                 670         


Glu Thr Lys Thr His Ala Thr Leu Phe Gly Ser Val Ala Cys Glu His 
        675                 680                 685             


Ile Ser Ser Thr Met Ser Gln Tyr Ser Arg Ser Thr Arg Ser Met Leu 
    690                 695                 700                 


Lys Arg Arg Asp Ser Thr Tyr Gly Pro Leu Gln Thr Pro Val Gly Cys 
705                 710                 715                 720 


Val Leu Gly Leu Val Asn Ser Ser Leu Phe Val Glu Asp Cys Lys Leu 
                725                 730                 735     


Pro Leu Gly Gln Ser Leu Cys Ala Leu Pro Asp Thr Pro Ser Thr Leu 
            740                 745                 750         


Thr Pro Ala Ser Val Gly Ser Val Pro Gly Glu Met Arg Leu Ala Ser 
        755                 760                 765             


Ile Ala Phe Asn His Pro Ile Gln Val Asp Gln Leu Asn Ser Ser Tyr 
    770                 775                 780                 


Phe Lys Leu Ser Ile Pro Thr Asn Phe Ser Phe Gly Val Thr Gln Glu 
785                 790                 795                 800 


Tyr Ile Gln Thr Thr Ile Gln Lys Val Thr Val Asp Cys Lys Gln Tyr 
                805                 810                 815     


Val Cys Asn Gly Phe Gln Lys Cys Glu Gln Leu Leu Arg Glu Tyr Gly 
            820                 825                 830         


Gln Phe Cys Ser Lys Ile Asn Gln Ala Leu His Gly Ala Asn Leu Arg 
        835                 840                 845             


Gln Asp Asp Ser Val Arg Asn Leu Phe Ala Ser Val Lys Ser Ser Gln 
    850                 855                 860                 


Ser Ser Pro Ile Ile Pro Gly Phe Gly Gly Asp Phe Asn Leu Thr Leu 
865                 870                 875                 880 


Leu Glu Pro Val Ser Ile Ser Thr Gly Ser Arg Ser Ala Arg Ser Ala 
                885                 890                 895     


Ile Glu Asp Leu Leu Phe Asp Lys Val Thr Ile Ala Asp Pro Gly Tyr 
            900                 905                 910         


Met Gln Gly Tyr Asp Asp Cys Met Gln Gln Gly Pro Ala Ser Ala Arg 
        915                 920                 925             


Asp Leu Ile Cys Ala Gln Tyr Val Ala Gly Tyr Lys Val Leu Pro Pro 
    930                 935                 940                 


Leu Met Asp Val Asn Met Glu Ala Ala Tyr Thr Ser Ser Leu Leu Gly 
945                 950                 955                 960 


Ser Ile Ala Gly Val Gly Trp Thr Ala Gly Leu Ser Ser Phe Ala Ala 
                965                 970                 975     


Ile Pro Phe Ala Gln Ser Ile Phe Tyr Arg Leu Asn Gly Val Gly Ile 
            980                 985                 990         


Thr Gln Gln Val Leu Ser Glu Asn  Gln Lys Leu Ile Ala  Asn Lys Phe 
        995                 1000                 1005             


Asn Gln  Ala Leu Gly Ala Met  Gln Thr Gly Phe Thr  Thr Thr Asn 
    1010                 1015                 1020             


Glu Ala  Phe His Lys Val Gln  Asp Ala Val Asn Asn  Asn Ala Gln 
    1025                 1030                 1035             


Ala Leu  Ser Lys Leu Ala Ser  Glu Leu Ser Asn Thr  Phe Gly Ala 
    1040                 1045                 1050             


Ile Ser  Ala Ser Ile Gly Asp  Ile Ile Gln Arg Leu  Asp Pro Pro 
    1055                 1060                 1065             


Glu Gln  Asp Ala Gln Ile Asp  Arg Leu Ile Asn Gly  Arg Leu Thr 
    1070                 1075                 1080             


Thr Leu  Asn Ala Phe Val Ala  Gln Gln Leu Val Arg  Ser Glu Ser 
    1085                 1090                 1095             


Ala Ala  Leu Ser Ala Gln Leu  Ala Lys Asp Lys Val  Asn Glu Cys 
    1100                 1105                 1110             


Val Lys  Ala Gln Ser Lys Arg  Ser Gly Phe Cys Gly  Gln Gly Thr 
    1115                 1120                 1125             


His Ile  Val Ser Phe Val Val  Asn Ala Pro Asn Gly  Leu Tyr Phe 
    1130                 1135                 1140             


Met His  Val Gly Tyr Tyr Pro  Ser Asn His Ile Glu  Val Val Ser 
    1145                 1150                 1155             


Ala Tyr  Gly Leu Cys Asp Ala  Ala Asn Pro Thr Asn  Cys Ile Ala 
    1160                 1165                 1170             


Pro Val  Asn Gly Tyr Phe Ile  Lys Thr Asn Asn Thr  Arg Ile Val 
    1175                 1180                 1185             


Asp Glu  Trp Ser Tyr Thr Gly  Ser Ser Phe Tyr Ala  Pro Glu Pro 
    1190                 1195                 1200             


Ile Thr  Ser Leu Asn Thr Lys  Tyr Val Ala Pro Gln  Val Thr Tyr 
    1205                 1210                 1215             


Gln Asn  Ile Ser Thr Asn Leu  Pro Pro Pro Leu Leu  Gly Asn Ser 
    1220                 1225                 1230             


Thr Gly  Ile Asp Phe Gln Asp  Glu Leu Asp Glu Phe  Phe Lys Asn 
    1235                 1240                 1245             


Val Ser  Thr Ser Ile Pro Asn  Phe Gly Ser Leu Thr  Gln Ile Asn 
    1250                 1255                 1260             


Thr Thr  Leu Leu Asp Leu Thr  Tyr Glu Met Leu Ser  Leu Gln Gln 
    1265                 1270                 1275             


Val Val  Lys Ala Leu Asn Glu  Ser Tyr Ile Asp Leu  Lys Glu Leu 
    1280                 1285                 1290             


Gly Asn  Tyr Thr Tyr Tyr Asn  Lys Trp Pro Trp Tyr  Gln Ile Leu 
    1295                 1300                 1305             


Ser Ile  Tyr Ser Thr Val Ala  Ser Ser Leu Ala Leu  Ala Ile Met 
    1310                 1315                 1320             


Met Ala  Gly Leu Ser Leu Trp  Met Cys Ser Asn Gly  Ser Leu Gln 
    1325                 1330                 1335             


Cys Arg  Ile Cys Ile 
    1340             


<210>  108
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-H5iCT-AA

<400>  108

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Tyr Val Asp Val Gly Pro Asp Ser 
            20                  25                  30          


Val Lys Ser Ala Cys Ile Glu Val Asp Ile Gln Gln Thr Phe Phe Asp 
        35                  40                  45              


Lys Thr Trp Pro Arg Pro Ile Asp Val Ser Lys Ala Asp Gly Ile Ile 
    50                  55                  60                  


Tyr Pro Gln Gly Arg Thr Tyr Ser Asn Ile Thr Ile Thr Tyr Gln Gly 
65                  70                  75                  80  


Leu Phe Pro Tyr Gln Gly Asp His Gly Asp Met Tyr Val Tyr Ser Ala 
                85                  90                  95      


Gly His Ala Thr Gly Thr Thr Pro Gln Lys Leu Phe Val Ala Asn Tyr 
            100                 105                 110         


Ser Gln Asp Val Lys Gln Phe Ala Asn Gly Phe Val Val Arg Ile Gly 
        115                 120                 125             


Ala Ala Ala Asn Ser Thr Gly Thr Val Ile Ile Ser Pro Ser Thr Ser 
    130                 135                 140                 


Ala Thr Ile Arg Lys Ile Tyr Pro Ala Phe Met Leu Gly Ser Ser Val 
145                 150                 155                 160 


Gly Asn Phe Ser Asp Gly Lys Met Gly Arg Phe Phe Asn His Thr Leu 
                165                 170                 175     


Val Leu Leu Pro Asp Gly Cys Gly Thr Leu Leu Arg Ala Phe Tyr Cys 
            180                 185                 190         


Ile Leu Glu Pro Arg Ser Gly Asn His Cys Pro Ala Gly Asn Ser Tyr 
        195                 200                 205             


Thr Ser Phe Ala Thr Tyr His Thr Pro Ala Thr Asp Cys Ser Asp Gly 
    210                 215                 220                 


Asn Tyr Asn Arg Asn Ala Ser Leu Asn Ser Phe Lys Glu Tyr Phe Asn 
225                 230                 235                 240 


Leu Arg Asn Cys Thr Phe Met Tyr Thr Tyr Asn Ile Thr Glu Asp Glu 
                245                 250                 255     


Ile Leu Glu Trp Phe Gly Ile Thr Gln Thr Ala Gln Gly Val His Leu 
            260                 265                 270         


Phe Ser Ser Arg Tyr Val Asp Leu Tyr Gly Gly Asn Met Phe Gln Phe 
        275                 280                 285             


Ala Thr Leu Pro Val Tyr Asp Thr Ile Lys Tyr Tyr Ser Ile Ile Pro 
    290                 295                 300                 


His Ser Ile Arg Ser Ile Gln Ser Asp Arg Lys Ala Trp Ala Ala Phe 
305                 310                 315                 320 


Tyr Val Tyr Lys Leu Gln Pro Leu Thr Phe Leu Leu Asp Phe Ser Val 
                325                 330                 335     


Asp Gly Tyr Ile Arg Arg Ala Ile Asp Cys Gly Phe Asn Asp Leu Ser 
            340                 345                 350         


Gln Leu His Cys Ser Tyr Glu Ser Phe Asp Val Glu Ser Gly Val Tyr 
        355                 360                 365             


Ser Val Ser Ser Phe Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln 
    370                 375                 380                 


Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro 
385                 390                 395                 400 


Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr 
                405                 410                 415     


Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys 
            420                 425                 430         


Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu 
        435                 440                 445             


Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser 
    450                 455                 460                 


Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe 
465                 470                 475                 480 


Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr 
                485                 490                 495     


Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg 
            500                 505                 510         


Phe Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn 
        515                 520                 525             


Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp 
    530                 535                 540                 


Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp 
545                 550                 555                 560 


Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met 
                565                 570                 575     


Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys 
            580                 585                 590         


Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly 
        595                 600                 605             


Asn Cys Val Glu Tyr Ser Leu Tyr Gly Val Ser Gly Arg Gly Val Phe 
    610                 615                 620                 


Gln Asn Cys Thr Ala Val Gly Val Arg Gln Gln Arg Phe Val Tyr Asp 
625                 630                 635                 640 


Ala Tyr Gln Asn Leu Val Gly Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr 
                645                 650                 655     


Cys Leu Arg Ala Cys Val Ser Val Pro Val Ser Val Ile Tyr Asp Lys 
            660                 665                 670         


Glu Thr Lys Thr His Ala Thr Leu Phe Gly Ser Val Ala Cys Glu His 
        675                 680                 685             


Ile Ser Ser Thr Met Ser Gln Tyr Ser Arg Ser Thr Arg Ser Met Leu 
    690                 695                 700                 


Lys Arg Arg Asp Ser Thr Tyr Gly Pro Leu Gln Thr Pro Val Gly Cys 
705                 710                 715                 720 


Val Leu Gly Leu Val Asn Ser Ser Leu Phe Val Glu Asp Cys Lys Leu 
                725                 730                 735     


Pro Leu Gly Gln Ser Leu Cys Ala Leu Pro Asp Thr Pro Ser Thr Leu 
            740                 745                 750         


Thr Pro Ala Ser Val Gly Ser Val Pro Gly Glu Met Arg Leu Ala Ser 
        755                 760                 765             


Ile Ala Phe Asn His Pro Ile Gln Val Asp Gln Leu Asn Ser Ser Tyr 
    770                 775                 780                 


Phe Lys Leu Ser Ile Pro Thr Asn Phe Ser Phe Gly Val Thr Gln Glu 
785                 790                 795                 800 


Tyr Ile Gln Thr Thr Ile Gln Lys Val Thr Val Asp Cys Lys Gln Tyr 
                805                 810                 815     


Val Cys Asn Gly Phe Gln Lys Cys Glu Gln Leu Leu Arg Glu Tyr Gly 
            820                 825                 830         


Gln Phe Cys Ser Lys Ile Asn Gln Ala Leu His Gly Ala Asn Leu Arg 
        835                 840                 845             


Gln Asp Asp Ser Val Arg Asn Leu Phe Ala Ser Val Lys Ser Ser Gln 
    850                 855                 860                 


Ser Ser Pro Ile Ile Pro Gly Phe Gly Gly Asp Phe Asn Leu Thr Leu 
865                 870                 875                 880 


Leu Glu Pro Val Ser Ile Ser Thr Gly Ser Arg Ser Ala Arg Ser Ala 
                885                 890                 895     


Ile Glu Asp Leu Leu Phe Asp Lys Val Thr Ile Ala Asp Pro Gly Tyr 
            900                 905                 910         


Met Gln Gly Tyr Asp Asp Cys Met Gln Gln Gly Pro Ala Ser Ala Arg 
        915                 920                 925             


Asp Leu Ile Cys Ala Gln Tyr Val Ala Gly Tyr Lys Val Leu Pro Pro 
    930                 935                 940                 


Leu Met Asp Val Asn Met Glu Ala Ala Tyr Thr Ser Ser Leu Leu Gly 
945                 950                 955                 960 


Ser Ile Ala Gly Val Gly Trp Thr Ala Gly Leu Ser Ser Phe Ala Ala 
                965                 970                 975     


Ile Pro Phe Ala Gln Ser Ile Phe Tyr Arg Leu Asn Gly Val Gly Ile 
            980                 985                 990         


Thr Gln Gln Val Leu Ser Glu Asn  Gln Lys Leu Ile Ala  Asn Lys Phe 
        995                 1000                 1005             


Asn Gln  Ala Leu Gly Ala Met  Gln Thr Gly Phe Thr  Thr Thr Asn 
    1010                 1015                 1020             


Glu Ala  Phe His Lys Val Gln  Asp Ala Val Asn Asn  Asn Ala Gln 
    1025                 1030                 1035             


Ala Leu  Ser Lys Leu Ala Ser  Glu Leu Ser Asn Thr  Phe Gly Ala 
    1040                 1045                 1050             


Ile Ser  Ala Ser Ile Gly Asp  Ile Ile Gln Arg Leu  Asp Pro Pro 
    1055                 1060                 1065             


Glu Gln  Asp Ala Gln Ile Asp  Arg Leu Ile Asn Gly  Arg Leu Thr 
    1070                 1075                 1080             


Thr Leu  Asn Ala Phe Val Ala  Gln Gln Leu Val Arg  Ser Glu Ser 
    1085                 1090                 1095             


Ala Ala  Leu Ser Ala Gln Leu  Ala Lys Asp Lys Val  Asn Glu Cys 
    1100                 1105                 1110             


Val Lys  Ala Gln Ser Lys Arg  Ser Gly Phe Cys Gly  Gln Gly Thr 
    1115                 1120                 1125             


His Ile  Val Ser Phe Val Val  Asn Ala Pro Asn Gly  Leu Tyr Phe 
    1130                 1135                 1140             


Met His  Val Gly Tyr Tyr Pro  Ser Asn His Ile Glu  Val Val Ser 
    1145                 1150                 1155             


Ala Tyr  Gly Leu Cys Asp Ala  Ala Asn Pro Thr Asn  Cys Ile Ala 
    1160                 1165                 1170             


Pro Val  Asn Gly Tyr Phe Ile  Lys Thr Asn Asn Thr  Arg Ile Val 
    1175                 1180                 1185             


Asp Glu  Trp Ser Tyr Thr Gly  Ser Ser Phe Tyr Ala  Pro Glu Pro 
    1190                 1195                 1200             


Ile Thr  Ser Leu Asn Thr Lys  Tyr Val Ala Pro Gln  Val Thr Tyr 
    1205                 1210                 1215             


Gln Asn  Ile Ser Thr Asn Leu  Pro Pro Pro Leu Leu  Gly Asn Ser 
    1220                 1225                 1230             


Thr Gly  Ile Asp Phe Gln Asp  Glu Leu Asp Glu Phe  Phe Lys Asn 
    1235                 1240                 1245             


Val Ser  Thr Ser Ile Pro Asn  Phe Gly Ser Leu Thr  Gln Ile Asn 
    1250                 1255                 1260             


Thr Thr  Leu Leu Asp Leu Thr  Tyr Glu Met Leu Ser  Leu Gln Gln 
    1265                 1270                 1275             


Val Val  Lys Ala Leu Asn Glu  Ser Tyr Ile Asp Leu  Lys Glu Leu 
    1280                 1285                 1290             


Gly Asn  Tyr Thr Tyr Tyr Asn  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1295                 1300                 1305             


Gly Phe  Ile Ala Gly Leu Val  Ala Leu Ala Leu Cys  Val Phe Phe 
    1310                 1315                 1320             


Ile Leu  Ser Leu Trp Met Cys  Ser Asn Gly Ser Leu  Gln Cys Arg 
    1325                 1330                 1335             


Ile Cys  Ile 
    1340     


<210>  109
<211>  1338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-H5iCT(V4)-AA

<400>  109

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Tyr Val Asp Val Gly Pro Asp Ser 
            20                  25                  30          


Val Lys Ser Ala Cys Ile Glu Val Asp Ile Gln Gln Thr Phe Phe Asp 
        35                  40                  45              


Lys Thr Trp Pro Arg Pro Ile Asp Val Ser Lys Ala Asp Gly Ile Ile 
    50                  55                  60                  


Tyr Pro Gln Gly Arg Thr Tyr Ser Asn Ile Thr Ile Thr Tyr Gln Gly 
65                  70                  75                  80  


Leu Phe Pro Tyr Gln Gly Asp His Gly Asp Met Tyr Val Tyr Ser Ala 
                85                  90                  95      


Gly His Ala Thr Gly Thr Thr Pro Gln Lys Leu Phe Val Ala Asn Tyr 
            100                 105                 110         


Ser Gln Asp Val Lys Gln Phe Ala Asn Gly Phe Val Val Arg Ile Gly 
        115                 120                 125             


Ala Ala Ala Asn Ser Thr Gly Thr Val Ile Ile Ser Pro Ser Thr Ser 
    130                 135                 140                 


Ala Thr Ile Arg Lys Ile Tyr Pro Ala Phe Met Leu Gly Ser Ser Val 
145                 150                 155                 160 


Gly Asn Phe Ser Asp Gly Lys Met Gly Arg Phe Phe Asn His Thr Leu 
                165                 170                 175     


Val Leu Leu Pro Asp Gly Cys Gly Thr Leu Leu Arg Ala Phe Tyr Cys 
            180                 185                 190         


Ile Leu Glu Pro Arg Ser Gly Asn His Cys Pro Ala Gly Asn Ser Tyr 
        195                 200                 205             


Thr Ser Phe Ala Thr Tyr His Thr Pro Ala Thr Asp Cys Ser Asp Gly 
    210                 215                 220                 


Asn Tyr Asn Arg Asn Ala Ser Leu Asn Ser Phe Lys Glu Tyr Phe Asn 
225                 230                 235                 240 


Leu Arg Asn Cys Thr Phe Met Tyr Thr Tyr Asn Ile Thr Glu Asp Glu 
                245                 250                 255     


Ile Leu Glu Trp Phe Gly Ile Thr Gln Thr Ala Gln Gly Val His Leu 
            260                 265                 270         


Phe Ser Ser Arg Tyr Val Asp Leu Tyr Gly Gly Asn Met Phe Gln Phe 
        275                 280                 285             


Ala Thr Leu Pro Val Tyr Asp Thr Ile Lys Tyr Tyr Ser Ile Ile Pro 
    290                 295                 300                 


His Ser Ile Arg Ser Ile Gln Ser Asp Arg Lys Ala Trp Ala Ala Phe 
305                 310                 315                 320 


Tyr Val Tyr Lys Leu Gln Pro Leu Thr Phe Leu Leu Asp Phe Ser Val 
                325                 330                 335     


Asp Gly Tyr Ile Arg Arg Ala Ile Asp Cys Gly Phe Asn Asp Leu Ser 
            340                 345                 350         


Gln Leu His Cys Ser Tyr Glu Ser Phe Asp Val Glu Ser Gly Val Tyr 
        355                 360                 365             


Ser Val Ser Ser Phe Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln 
    370                 375                 380                 


Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro 
385                 390                 395                 400 


Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr 
                405                 410                 415     


Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys 
            420                 425                 430         


Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu 
        435                 440                 445             


Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser 
    450                 455                 460                 


Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe 
465                 470                 475                 480 


Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr 
                485                 490                 495     


Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg 
            500                 505                 510         


Phe Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn 
        515                 520                 525             


Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp 
    530                 535                 540                 


Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp 
545                 550                 555                 560 


Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met 
                565                 570                 575     


Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys 
            580                 585                 590         


Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly 
        595                 600                 605             


Asn Cys Val Glu Tyr Ser Leu Tyr Gly Val Ser Gly Arg Gly Val Phe 
    610                 615                 620                 


Gln Asn Cys Thr Ala Val Gly Val Arg Gln Gln Arg Phe Val Tyr Asp 
625                 630                 635                 640 


Ala Tyr Gln Asn Leu Val Gly Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr 
                645                 650                 655     


Cys Leu Arg Ala Cys Val Ser Val Pro Val Ser Val Ile Tyr Asp Lys 
            660                 665                 670         


Glu Thr Lys Thr His Ala Thr Leu Phe Gly Ser Val Ala Cys Glu His 
        675                 680                 685             


Ile Ser Ser Thr Met Ser Gln Tyr Ser Arg Ser Thr Arg Ser Met Leu 
    690                 695                 700                 


Lys Arg Arg Asp Ser Thr Tyr Gly Pro Leu Gln Thr Pro Val Gly Cys 
705                 710                 715                 720 


Val Leu Gly Leu Val Asn Ser Ser Leu Phe Val Glu Asp Cys Lys Leu 
                725                 730                 735     


Pro Leu Gly Gln Ser Leu Cys Ala Leu Pro Asp Thr Pro Ser Thr Leu 
            740                 745                 750         


Thr Pro Ala Ser Val Gly Ser Val Pro Gly Glu Met Arg Leu Ala Ser 
        755                 760                 765             


Ile Ala Phe Asn His Pro Ile Gln Val Asp Gln Leu Asn Ser Ser Tyr 
    770                 775                 780                 


Phe Lys Leu Ser Ile Pro Thr Asn Phe Ser Phe Gly Val Thr Gln Glu 
785                 790                 795                 800 


Tyr Ile Gln Thr Thr Ile Gln Lys Val Thr Val Asp Cys Lys Gln Tyr 
                805                 810                 815     


Val Cys Asn Gly Phe Gln Lys Cys Glu Gln Leu Leu Arg Glu Tyr Gly 
            820                 825                 830         


Gln Phe Cys Ser Lys Ile Asn Gln Ala Leu His Gly Ala Asn Leu Arg 
        835                 840                 845             


Gln Asp Asp Ser Val Arg Asn Leu Phe Ala Ser Val Lys Ser Ser Gln 
    850                 855                 860                 


Ser Ser Pro Ile Ile Pro Gly Phe Gly Gly Asp Phe Asn Leu Thr Leu 
865                 870                 875                 880 


Leu Glu Pro Val Ser Ile Ser Thr Gly Ser Arg Ser Ala Arg Ser Ala 
                885                 890                 895     


Ile Glu Asp Leu Leu Phe Asp Lys Val Thr Ile Ala Asp Pro Gly Tyr 
            900                 905                 910         


Met Gln Gly Tyr Asp Asp Cys Met Gln Gln Gly Pro Ala Ser Ala Arg 
        915                 920                 925             


Asp Leu Ile Cys Ala Gln Tyr Val Ala Gly Tyr Lys Val Leu Pro Pro 
    930                 935                 940                 


Leu Met Asp Val Asn Met Glu Ala Ala Tyr Thr Ser Ser Leu Leu Gly 
945                 950                 955                 960 


Ser Ile Ala Gly Val Gly Trp Thr Ala Gly Leu Ser Ser Phe Ala Ala 
                965                 970                 975     


Ile Pro Phe Ala Gln Ser Ile Phe Tyr Arg Leu Asn Gly Val Gly Ile 
            980                 985                 990         


Thr Gln Gln Val Leu Ser Glu Asn  Gln Lys Leu Ile Ala  Asn Lys Phe 
        995                 1000                 1005             


Asn Gln  Ala Leu Gly Ala Met  Gln Thr Gly Phe Thr  Thr Thr Asn 
    1010                 1015                 1020             


Glu Ala  Phe His Lys Val Gln  Asp Ala Val Asn Asn  Asn Ala Gln 
    1025                 1030                 1035             


Ala Leu  Ser Lys Leu Ala Ser  Glu Leu Ser Asn Thr  Phe Gly Ala 
    1040                 1045                 1050             


Ile Ser  Ala Ser Ile Gly Asp  Ile Ile Gln Arg Leu  Asp Pro Pro 
    1055                 1060                 1065             


Glu Gln  Asp Ala Gln Ile Asp  Arg Leu Ile Asn Gly  Arg Leu Thr 
    1070                 1075                 1080             


Thr Leu  Asn Ala Phe Val Ala  Gln Gln Leu Val Arg  Ser Glu Ser 
    1085                 1090                 1095             


Ala Ala  Leu Ser Ala Gln Leu  Ala Lys Asp Lys Val  Asn Glu Cys 
    1100                 1105                 1110             


Val Lys  Ala Gln Ser Lys Arg  Ser Gly Phe Cys Gly  Gln Gly Thr 
    1115                 1120                 1125             


His Ile  Val Ser Phe Val Val  Asn Ala Pro Asn Gly  Leu Tyr Phe 
    1130                 1135                 1140             


Met His  Val Gly Tyr Tyr Pro  Ser Asn His Ile Glu  Val Val Ser 
    1145                 1150                 1155             


Ala Tyr  Gly Leu Cys Asp Ala  Ala Asn Pro Thr Asn  Cys Ile Ala 
    1160                 1165                 1170             


Pro Val  Asn Gly Tyr Phe Ile  Lys Thr Asn Asn Thr  Arg Ile Val 
    1175                 1180                 1185             


Asp Glu  Trp Ser Tyr Thr Gly  Ser Ser Phe Tyr Ala  Pro Glu Pro 
    1190                 1195                 1200             


Ile Thr  Ser Leu Asn Thr Lys  Tyr Val Ala Pro Gln  Val Thr Tyr 
    1205                 1210                 1215             


Gln Asn  Ile Ser Thr Asn Leu  Pro Pro Pro Leu Leu  Gly Asn Ser 
    1220                 1225                 1230             


Thr Gly  Ile Asp Phe Gln Asp  Glu Leu Asp Glu Phe  Phe Lys Asn 
    1235                 1240                 1245             


Val Ser  Thr Ser Ile Pro Asn  Phe Gly Ser Leu Thr  Gln Ile Asn 
    1250                 1255                 1260             


Thr Thr  Leu Leu Asp Leu Thr  Tyr Glu Met Leu Ser  Leu Gln Gln 
    1265                 1270                 1275             


Val Val  Lys Ala Leu Asn Glu  Ser Tyr Ile Asp Leu  Lys Glu Leu 
    1280                 1285                 1290             


Gly Asn  Tyr Thr Tyr Tyr Asn  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1295                 1300                 1305             


Gly Phe  Ile Ala Gly Leu Val  Ala Leu Ala Leu Cys  Val Phe Phe 
    1310                 1315                 1320             


Ile Leu  Cys Cys Ser Asn Gly  Ser Leu Gln Cys Arg  Ile Cys Ile 
    1325                 1330                 1335             


<210>  110
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-MERS-H1cCT-AA

<400>  110

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Tyr Val Asp Val Gly Pro Asp Ser 
            20                  25                  30          


Val Lys Ser Ala Cys Ile Glu Val Asp Ile Gln Gln Thr Phe Phe Asp 
        35                  40                  45              


Lys Thr Trp Pro Arg Pro Ile Asp Val Ser Lys Ala Asp Gly Ile Ile 
    50                  55                  60                  


Tyr Pro Gln Gly Arg Thr Tyr Ser Asn Ile Thr Ile Thr Tyr Gln Gly 
65                  70                  75                  80  


Leu Phe Pro Tyr Gln Gly Asp His Gly Asp Met Tyr Val Tyr Ser Ala 
                85                  90                  95      


Gly His Ala Thr Gly Thr Thr Pro Gln Lys Leu Phe Val Ala Asn Tyr 
            100                 105                 110         


Ser Gln Asp Val Lys Gln Phe Ala Asn Gly Phe Val Val Arg Ile Gly 
        115                 120                 125             


Ala Ala Ala Asn Ser Thr Gly Thr Val Ile Ile Ser Pro Ser Thr Ser 
    130                 135                 140                 


Ala Thr Ile Arg Lys Ile Tyr Pro Ala Phe Met Leu Gly Ser Ser Val 
145                 150                 155                 160 


Gly Asn Phe Ser Asp Gly Lys Met Gly Arg Phe Phe Asn His Thr Leu 
                165                 170                 175     


Val Leu Leu Pro Asp Gly Cys Gly Thr Leu Leu Arg Ala Phe Tyr Cys 
            180                 185                 190         


Ile Leu Glu Pro Arg Ser Gly Asn His Cys Pro Ala Gly Asn Ser Tyr 
        195                 200                 205             


Thr Ser Phe Ala Thr Tyr His Thr Pro Ala Thr Asp Cys Ser Asp Gly 
    210                 215                 220                 


Asn Tyr Asn Arg Asn Ala Ser Leu Asn Ser Phe Lys Glu Tyr Phe Asn 
225                 230                 235                 240 


Leu Arg Asn Cys Thr Phe Met Tyr Thr Tyr Asn Ile Thr Glu Asp Glu 
                245                 250                 255     


Ile Leu Glu Trp Phe Gly Ile Thr Gln Thr Ala Gln Gly Val His Leu 
            260                 265                 270         


Phe Ser Ser Arg Tyr Val Asp Leu Tyr Gly Gly Asn Met Phe Gln Phe 
        275                 280                 285             


Ala Thr Leu Pro Val Tyr Asp Thr Ile Lys Tyr Tyr Ser Ile Ile Pro 
    290                 295                 300                 


His Ser Ile Arg Ser Ile Gln Ser Asp Arg Lys Ala Trp Ala Ala Phe 
305                 310                 315                 320 


Tyr Val Tyr Lys Leu Gln Pro Leu Thr Phe Leu Leu Asp Phe Ser Val 
                325                 330                 335     


Asp Gly Tyr Ile Arg Arg Ala Ile Asp Cys Gly Phe Asn Asp Leu Ser 
            340                 345                 350         


Gln Leu His Cys Ser Tyr Glu Ser Phe Asp Val Glu Ser Gly Val Tyr 
        355                 360                 365             


Ser Val Ser Ser Phe Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln 
    370                 375                 380                 


Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro 
385                 390                 395                 400 


Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr 
                405                 410                 415     


Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys 
            420                 425                 430         


Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu 
        435                 440                 445             


Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser 
    450                 455                 460                 


Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe 
465                 470                 475                 480 


Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr 
                485                 490                 495     


Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg 
            500                 505                 510         


Phe Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn 
        515                 520                 525             


Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp 
    530                 535                 540                 


Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp 
545                 550                 555                 560 


Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met 
                565                 570                 575     


Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys 
            580                 585                 590         


Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly 
        595                 600                 605             


Asn Cys Val Glu Tyr Ser Leu Tyr Gly Val Ser Gly Arg Gly Val Phe 
    610                 615                 620                 


Gln Asn Cys Thr Ala Val Gly Val Arg Gln Gln Arg Phe Val Tyr Asp 
625                 630                 635                 640 


Ala Tyr Gln Asn Leu Val Gly Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr 
                645                 650                 655     


Cys Leu Arg Ala Cys Val Ser Val Pro Val Ser Val Ile Tyr Asp Lys 
            660                 665                 670         


Glu Thr Lys Thr His Ala Thr Leu Phe Gly Ser Val Ala Cys Glu His 
        675                 680                 685             


Ile Ser Ser Thr Met Ser Gln Tyr Ser Arg Ser Thr Arg Ser Met Leu 
    690                 695                 700                 


Lys Arg Arg Asp Ser Thr Tyr Gly Pro Leu Gln Thr Pro Val Gly Cys 
705                 710                 715                 720 


Val Leu Gly Leu Val Asn Ser Ser Leu Phe Val Glu Asp Cys Lys Leu 
                725                 730                 735     


Pro Leu Gly Gln Ser Leu Cys Ala Leu Pro Asp Thr Pro Ser Thr Leu 
            740                 745                 750         


Thr Pro Ala Ser Val Gly Ser Val Pro Gly Glu Met Arg Leu Ala Ser 
        755                 760                 765             


Ile Ala Phe Asn His Pro Ile Gln Val Asp Gln Leu Asn Ser Ser Tyr 
    770                 775                 780                 


Phe Lys Leu Ser Ile Pro Thr Asn Phe Ser Phe Gly Val Thr Gln Glu 
785                 790                 795                 800 


Tyr Ile Gln Thr Thr Ile Gln Lys Val Thr Val Asp Cys Lys Gln Tyr 
                805                 810                 815     


Val Cys Asn Gly Phe Gln Lys Cys Glu Gln Leu Leu Arg Glu Tyr Gly 
            820                 825                 830         


Gln Phe Cys Ser Lys Ile Asn Gln Ala Leu His Gly Ala Asn Leu Arg 
        835                 840                 845             


Gln Asp Asp Ser Val Arg Asn Leu Phe Ala Ser Val Lys Ser Ser Gln 
    850                 855                 860                 


Ser Ser Pro Ile Ile Pro Gly Phe Gly Gly Asp Phe Asn Leu Thr Leu 
865                 870                 875                 880 


Leu Glu Pro Val Ser Ile Ser Thr Gly Ser Arg Ser Ala Arg Ser Ala 
                885                 890                 895     


Ile Glu Asp Leu Leu Phe Asp Lys Val Thr Ile Ala Asp Pro Gly Tyr 
            900                 905                 910         


Met Gln Gly Tyr Asp Asp Cys Met Gln Gln Gly Pro Ala Ser Ala Arg 
        915                 920                 925             


Asp Leu Ile Cys Ala Gln Tyr Val Ala Gly Tyr Lys Val Leu Pro Pro 
    930                 935                 940                 


Leu Met Asp Val Asn Met Glu Ala Ala Tyr Thr Ser Ser Leu Leu Gly 
945                 950                 955                 960 


Ser Ile Ala Gly Val Gly Trp Thr Ala Gly Leu Ser Ser Phe Ala Ala 
                965                 970                 975     


Ile Pro Phe Ala Gln Ser Ile Phe Tyr Arg Leu Asn Gly Val Gly Ile 
            980                 985                 990         


Thr Gln Gln Val Leu Ser Glu Asn  Gln Lys Leu Ile Ala  Asn Lys Phe 
        995                 1000                 1005             


Asn Gln  Ala Leu Gly Ala Met  Gln Thr Gly Phe Thr  Thr Thr Asn 
    1010                 1015                 1020             


Glu Ala  Phe His Lys Val Gln  Asp Ala Val Asn Asn  Asn Ala Gln 
    1025                 1030                 1035             


Ala Leu  Ser Lys Leu Ala Ser  Glu Leu Ser Asn Thr  Phe Gly Ala 
    1040                 1045                 1050             


Ile Ser  Ala Ser Ile Gly Asp  Ile Ile Gln Arg Leu  Asp Pro Pro 
    1055                 1060                 1065             


Glu Gln  Asp Ala Gln Ile Asp  Arg Leu Ile Asn Gly  Arg Leu Thr 
    1070                 1075                 1080             


Thr Leu  Asn Ala Phe Val Ala  Gln Gln Leu Val Arg  Ser Glu Ser 
    1085                 1090                 1095             


Ala Ala  Leu Ser Ala Gln Leu  Ala Lys Asp Lys Val  Asn Glu Cys 
    1100                 1105                 1110             


Val Lys  Ala Gln Ser Lys Arg  Ser Gly Phe Cys Gly  Gln Gly Thr 
    1115                 1120                 1125             


His Ile  Val Ser Phe Val Val  Asn Ala Pro Asn Gly  Leu Tyr Phe 
    1130                 1135                 1140             


Met His  Val Gly Tyr Tyr Pro  Ser Asn His Ile Glu  Val Val Ser 
    1145                 1150                 1155             


Ala Tyr  Gly Leu Cys Asp Ala  Ala Asn Pro Thr Asn  Cys Ile Ala 
    1160                 1165                 1170             


Pro Val  Asn Gly Tyr Phe Ile  Lys Thr Asn Asn Thr  Arg Ile Val 
    1175                 1180                 1185             


Asp Glu  Trp Ser Tyr Thr Gly  Ser Ser Phe Tyr Ala  Pro Glu Pro 
    1190                 1195                 1200             


Ile Thr  Ser Leu Asn Thr Lys  Tyr Val Ala Pro Gln  Val Thr Tyr 
    1205                 1210                 1215             


Gln Asn  Ile Ser Thr Asn Leu  Pro Pro Pro Leu Leu  Gly Asn Ser 
    1220                 1225                 1230             


Thr Gly  Ile Asp Phe Gln Asp  Glu Leu Asp Glu Phe  Phe Lys Asn 
    1235                 1240                 1245             


Val Ser  Thr Ser Ile Pro Asn  Phe Gly Ser Leu Thr  Gln Ile Asn 
    1250                 1255                 1260             


Thr Thr  Leu Leu Asp Leu Thr  Tyr Glu Met Leu Ser  Leu Gln Gln 
    1265                 1270                 1275             


Val Val  Lys Ala Leu Asn Glu  Ser Tyr Ile Asp Leu  Lys Glu Leu 
    1280                 1285                 1290             


Gly Asn  Tyr Thr Tyr Tyr Asn  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1295                 1300                 1305             


Gly Phe  Ile Ala Gly Leu Val  Ala Leu Ala Leu Cys  Val Phe Phe 
    1310                 1315                 1320             


Ile Leu  Ser Phe Trp Met Cys  Ser Asn Gly Ser Leu  Gln Cys Arg 
    1325                 1330                 1335             


Ile Cys  Ile 
    1340     


<210>  111
<211>  4364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cloning vector 7147 from left to right T-DNA

<400>  111
tggcaggata tattgtggtg taaacaaatt gacgcttaga caacttaata acacattgcg       60

gacgttttta atgtactgaa ttaacgccga atcccgggct ggtatattta tatgttgtca      120

aataactcaa aaaccataaa agtttaagtt agcaagtgtg tacattttta cttgaacaaa      180

aatattcacc tactactgtt ataaatcatt attaaacatt agagtaaaga aatatggatg      240

ataagaacaa gagtagtgat attttgacaa caattttgtt gcaacatttg agaaaatttt      300

gttgttctct cttttcattg gtcaaaaaca atagagagag aaaaaggaag agggagaata      360

aaaacataat gtgagtatga gagagaaagt tgtacaaaag ttgtaccaaa atagttgtac      420

aaatatcatt gaggaatttg acaaaagcta cacaaataag ggttaattgc tgtaaataaa      480

taaggatgac gcattagaga gatgtaccat tagagaattt ttggcaagtc attaaaaaga      540

aagaataaat tatttttaaa attaaaagtt gagtcatttg attaaacatg tgattattta      600

atgaattgat gaaagagttg gattaaagtt gtattagtaa ttagaatttg gtgtcaaatt      660

taatttgaca tttgatcttt tcctatatat tgccccatag agtcagttaa ctcattttta      720

tatttcatag atcaaataag agaaataacg gtatattaat ccctccaaaa aaaaaaaacg      780

gtatatttac taaaaaatct aagccacgta ggaggataac aggatccccg taggaggata      840

acatccaatc caaccaatca caacaatcct gatgagataa cccactttaa gcccacgcat      900

ctgtggcaca tctacattat ctaaatcaca cattcttcca cacatctgag ccacacaaaa      960

accaatccac atctttatca cccattctat aaaaaatcac actttgtgag tctacacttt     1020

gattcccttc aaacacatac aaagagaaga gactaattaa ttaattaatc atcttgagag     1080

aaaatggaac gagctataca aggaaacgac gctagggaac aagctaacag tgaacgttgg     1140

gatggaggat caggaggtac cacttctccc ttcaaacttc ctgacgaaag tccgagttgg     1200

actgagtggc ggctacataa cgatgagacg aattcgaatc aagataatcc ccttggtttc     1260

aaggaaagct ggggtttcgg gaaagttgta tttaagagat atctcagata cgacaggacg     1320

gaagcttcac tgcacagagt ccttggatct tggacgggag attcggttaa ctatgcagca     1380

tctcgatttt tcggtttcga ccagatcgga tgtacctata gtattcggtt tcgaggagtt     1440

agtatcaccg tttctggagg gtcgcgaact cttcagcatc tctgtgagat ggcaattcgg     1500

tctaagcaag aactgctaca gcttgcccca atcgaagtgg aaagtaatgt atcaagagga     1560

tgccctgaag gtactcaaac cttcgaaaaa gaaagcgagt aagttaaaat gcttcttcgt     1620

ctcctattta taatatggtt tgttattgtt aattttgttc ttgtagaaga gcttaattaa     1680

tcgttgttgt tatgaaatac tatttgtatg agatgaactg gtgtaatgta attcatttac     1740

ataagtggag tcagaatcag aatgtttcct ccataactaa ctagacatga agacctgccg     1800

cgtacaattg tcttatattt gaacaactaa aattgaacat cttttgccac aactttataa     1860

gtggttaata tagctcaaat atatggtcaa gttcaataga ttaataatgg aaatatcagt     1920

tatcgaaatt cattaacaat caacttaacg ttattaacta ctaattttat atcatcccct     1980

ttgataaatg atagtacacc aattaggaag gagcatgctc gcctaggaga ttgtcgtttc     2040

ccgccttcag tttgcaagct gctctagccg tgtagccaat acgcaaaccg cctctccccg     2100

cgcgttggga attactagcg cgtgtcgaca agcttgcatg ccggtcaaca tggtggagca     2160

cgacacactt gtctactcca aaaatatcaa agatacagtc tcagaagacc aaagggcaat     2220

tgagactttt caacaaaggg taatatccgg aaacctcctc ggattccatt gcccagctat     2280

ctgtcacttt attgtgaaga tagtggaaaa ggaaggtggc tcctacaaat gccatcattg     2340

cgataaagga aaggccatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc     2400

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt     2460

ggattgatgt gataacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga     2520

tacagtctca gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa     2580

cctcctcgga ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga     2640

aggtggctcc tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc     2700

tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga     2760

cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg acgtaaggga     2820

tgacgcacaa tcccactatc cttcgcaaga cccttcctct atataaggaa gttcatttca     2880

tttggagagg cactccattt gaatctatca aaccaaaaca cattgagacg tcacgtactc     2940

ctcagccaaa acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac     3000

taactccatg gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt     3060

gacctggaac tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc     3120

tgacctctac actctgagca gctcagtgac tgtcccctcc agcacctggc ccagcgagac     3180

cgtcacctgc aacgttgccc acccggccag cagcaccaag gtggacaaga aaattgtgcc     3240

cagggattgt ggttgtaagc cttgcatatg tacagtccca gaagtatcat ctgtcttcat     3300

cttcccccca aagcccaagg atgtgctcac cattactctg actcctaagg tcacgtgtgt     3360

tgtggtagac atcagcaagg atgatcccga ggtccagttc agctggtttg tagatgatgt     3420

ggaggtgcac acagctcaga cgcaaccccg ggaggagcag ttcaacagca ctttccgctc     3480

agtcagtgaa cttcccatca tgcaccagga ctggctcaat ggcaaggaga cgtccagatt     3540

ttggcgatct attcaactgt cgccagttca ttggtactgg tagtctccct gggggcaatc     3600

agtttctgga tgtgctctaa tgggtctcta cagtgtagaa tatgtattta aaggccttag     3660

tcgtgtcgtt tttcaaataa tataatcctt ttagggtttt agttagttta aattttctgt     3720

tgctcctgtt tagcaggtcg tgccttcagc aagcacacaa aaacagagtg tttattttaa     3780

gttgtttgtt tagtgattca aaaaaaaaat cgttcaaaca tttggcaata aagtttctta     3840

agattgaatc ctgttgccgg tcttgcgatg attatcatat aatttctgtt gaattacgtt     3900

aagcatgtaa taattaacat gtaatgcatg acgttattta tgagatgggt ttttatgatt     3960

agagtcccgc aattatacat ttaatacgcg atagaaaaca aaatatagcg cgcaaactag     4020

gataaattat cgcgcgcggt gtcatctatg ttactagatc tctagagtct caagcttggc     4080

gcgcccacgt gactagtggc actggccgtc gttttacaac gtcgtgactg ggaaaaccct     4140

ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc     4200

gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgctag     4260

agcagcttga gcttggatca gattgtcgtt tcccgccttc agtttaaact atcagtgttt     4320

gacaggatat attggcgggt aaacctaaga gaaaagagcg ttta                      4364


<210>  112
<211>  1255
<212>  PRT
<213>  SARS-CoV-1

<400>  112

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Val Trp Leu  Gly Phe Ile 
    1190                 1195                 1200             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Leu  Leu Cys Cys 
    1205                 1210                 1215             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Ala Cys  Ser Cys Gly 
    1220                 1225                 1230             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1235                 1240                 1245             


Gly Val  Lys Leu His Tyr Thr  
    1250                 1255 


<210>  113
<211>  1353
<212>  PRT
<213>  MERS

<400>  113

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe His  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn Arg  Cys Cys Asp 
    1325                 1330                 1335             


Arg Tyr  Glu Glu Tyr Asp Leu  Glu Pro His Lys Val  His Val His 
    1340                 1345                 1350             


<210>  114
<211>  1242
<212>  PRT
<213>  SARS-CoV-1

<400>  114

Ser Asp Leu Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn 
1               5                   10                  15      


Tyr Thr Gln His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu 
            20                  25                  30          


Ile Phe Arg Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro 
        35                  40                  45              


Phe Tyr Ser Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly 
    50                  55                  60                  


Asn Pro Val Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu 
65                  70                  75                  80  


Lys Ser Asn Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn 
                85                  90                  95      


Lys Ser Gln Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile 
            100                 105                 110         


Arg Ala Cys Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser 
        115                 120                 125             


Lys Pro Met Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe 
    130                 135                 140                 


Asn Cys Thr Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser 
145                 150                 155                 160 


Glu Lys Ser Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn 
                165                 170                 175     


Lys Asp Gly Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val 
            180                 185                 190         


Val Arg Asp Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys 
        195                 200                 205             


Leu Pro Leu Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala 
    210                 215                 220                 


Phe Ser Pro Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe 
225                 230                 235                 240 


Val Gly Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn 
                245                 250                 255     


Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu 
            260                 265                 270         


Leu Lys Cys Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln 
        275                 280                 285             


Thr Ser Asn Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro 
    290                 295                 300                 


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys 
305                 310                 315                 320 


Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val 
                325                 330                 335     


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys 
            340                 345                 350         


Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn 
        355                 360                 365             


Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile 
    370                 375                 380                 


Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
385                 390                 395                 400 


Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp 
                405                 410                 415     


Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His 
            420                 425                 430         


Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser 
        435                 440                 445             


Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro 
    450                 455                 460                 


Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro 
465                 470                 475                 480 


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr 
                485                 490                 495     


Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val 
            500                 505                 510         


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser 
        515                 520                 525             


Ser Lys Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp 
    530                 535                 540                 


Phe Thr Asp Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile 
545                 550                 555                 560 


Ser Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
                565                 570                 575     


Ala Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp 
            580                 585                 590         


Val Ser Thr Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile 
        595                 600                 605             


Tyr Ser Thr Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile 
    610                 615                 620                 


Gly Ala Glu His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
625                 630                 635                 640 


Ala Gly Ile Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr 
                645                 650                 655     


Ser Gln Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser 
            660                 665                 670         


Ser Ile Ala Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser 
        675                 680                 685             


Ile Ser Ile Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser 
    690                 695                 700                 


Val Asp Cys Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn 
705                 710                 715                 720 


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
                725                 730                 735     


Ser Gly Ile Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala 
            740                 745                 750         


Gln Val Lys Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly 
        755                 760                 765             


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg 
    770                 775                 780                 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
785                 790                 795                 800 


Gly Phe Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg 
                805                 810                 815     


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
            820                 825                 830         


Leu Leu Thr Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser 
        835                 840                 845             


Gly Thr Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
    850                 855                 860                 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
865                 870                 875                 880 


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe 
                885                 890                 895     


Asn Lys Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr 
            900                 905                 910         


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
        915                 920                 925             


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
    930                 935                 940                 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
945                 950                 955                 960 


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
                965                 970                 975     


Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 
            980                 985                 990         


Leu Ala Ala Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
        995                 1000                 1005             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1010                 1015                 1020             


Ala Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1025                 1030                 1035             


Ser Gln  Glu Arg Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Glu 
    1040                 1045                 1050             


Gly Lys  Ala Tyr Phe Pro Arg  Glu Gly Val Phe Val  Phe Asn Gly 
    1055                 1060                 1065             


Thr Ser  Trp Phe Ile Thr Gln  Arg Asn Phe Phe Ser  Pro Gln Ile 
    1070                 1075                 1080             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1085                 1090                 1095             


Ile Gly  Ile Ile Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1100                 1105                 1110             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1115                 1120                 1125             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1130                 1135                 1140             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1145                 1150                 1155             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1160                 1165                 1170             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Val  Trp Leu Gly 
    1175                 1180                 1185             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Leu Leu 
    1190                 1195                 1200             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Ala Cys Ser 
    1205                 1210                 1215             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1220                 1225                 1230             


Leu Lys  Gly Val Lys Leu His  Tyr Thr 
    1235                 1240         


<210>  115
<211>  1336
<212>  PRT
<213>  MERS

<400>  115

Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu Val 
1               5                   10                  15      


Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile Asp 
            20                  25                  30          


Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr Ser 
        35                  40                  45              


Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp His 
    50                  55                  60                  


Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr Pro 
65                  70                  75                  80  


Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe Ala 
                85                  90                  95      


Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly Thr 
            100                 105                 110         


Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr Pro 
        115                 120                 125             


Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys Met 
    130                 135                 140                 


Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys Gly 
145                 150                 155                 160 


Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly Asn 
                165                 170                 175     


His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His Thr 
            180                 185                 190         


Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser Leu 
        195                 200                 205             


Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met Tyr 
    210                 215                 220                 


Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile Thr 
225                 230                 235                 240 


Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp Leu 
                245                 250                 255     


Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp Thr 
            260                 265                 270         


Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln Ser 
        275                 280                 285             


Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro Leu 
    290                 295                 300                 


Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala Ile 
305                 310                 315                 320 


Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu Ser 
                325                 330                 335     


Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala Lys 
            340                 345                 350         


Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp Phe 
        355                 360                 365             


Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg 
    370                 375                 380                 


Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu 
385                 390                 395                 400 


Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile 
                405                 410                 415     


Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro 
            420                 425                 430         


Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser 
        435                 440                 445             


Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu 
    450                 455                 460                 


Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr 
465                 470                 475                 480 


Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr Glu 
                485                 490                 495     


Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile 
            500                 505                 510         


Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu 
        515                 520                 525             


Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val 
    530                 535                 540                 


Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln Tyr 
545                 550                 555                 560 


Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn Asp 
                565                 570                 575     


Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu Tyr 
            580                 585                 590         


Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly Val 
        595                 600                 605             


Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly Tyr 
    610                 615                 620                 


Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser Val 
625                 630                 635                 640 


Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr Leu 
                645                 650                 655     


Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln Tyr 
            660                 665                 670         


Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr Gly 
        675                 680                 685             


Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser Ser 
    690                 695                 700                 


Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys Ala 
705                 710                 715                 720 


Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser Val 
                725                 730                 735     


Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile Gln 
            740                 745                 750         


Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr Asn 
        755                 760                 765             


Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln Lys 
    770                 775                 780                 


Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys Cys 
785                 790                 795                 800 


Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn Gln 
                805                 810                 815     


Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn Leu 
            820                 825                 830         


Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly Phe 
        835                 840                 845             


Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser Thr 
    850                 855                 860                 


Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp Lys 
865                 870                 875                 880 


Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys Met 
                885                 890                 895     


Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr Val 
            900                 905                 910         


Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu Ala 
        915                 920                 925             


Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp Thr 
    930                 935                 940                 


Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile Phe 
945                 950                 955                 960 


Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu Asn 
                965                 970                 975     


Gln Lys Leu Ile Ala Asn Lys Phe Asn Gln Ala Leu Gly Ala Met Gln 
            980                 985                 990         


Thr Gly Phe Thr Thr Thr Asn Glu  Ala Phe His Lys Val  Gln Asp Ala 
        995                 1000                 1005             


Val Asn  Asn Asn Ala Gln Ala  Leu Ser Lys Leu Ala  Ser Glu Leu 
    1010                 1015                 1020             


Ser Asn  Thr Phe Gly Ala Ile  Ser Ala Ser Ile Gly  Asp Ile Ile 
    1025                 1030                 1035             


Gln Arg  Leu Asp Val Leu Glu  Gln Asp Ala Gln Ile  Asp Arg Leu 
    1040                 1045                 1050             


Ile Asn  Gly Arg Leu Thr Thr  Leu Asn Ala Phe Val  Ala Gln Gln 
    1055                 1060                 1065             


Leu Val  Arg Ser Glu Ser Ala  Ala Leu Ser Ala Gln  Leu Ala Lys 
    1070                 1075                 1080             


Asp Lys  Val Asn Glu Cys Val  Lys Ala Gln Ser Lys  Arg Ser Gly 
    1085                 1090                 1095             


Phe Cys  Gly Gln Gly Thr His  Ile Val Ser Phe Val  Val Asn Ala 
    1100                 1105                 1110             


Pro Asn  Gly Leu Tyr Phe Met  His Val Gly Tyr Tyr  Pro Ser Asn 
    1115                 1120                 1125             


His Ile  Glu Val Val Ser Ala  Tyr Gly Leu Cys Asp  Ala Ala Asn 
    1130                 1135                 1140             


Pro Thr  Asn Cys Ile Ala Pro  Val Asn Gly Tyr Phe  Ile Lys Thr 
    1145                 1150                 1155             


Asn Asn  Thr Arg Ile Val Asp  Glu Trp Ser Tyr Thr  Gly Ser Ser 
    1160                 1165                 1170             


Phe Tyr  Ala Pro Glu Pro Ile  Thr Ser Leu Asn Thr  Lys Tyr Val 
    1175                 1180                 1185             


Ala Pro  Gln Val Thr Tyr Gln  Asn Ile Ser Thr Asn  Leu Pro Pro 
    1190                 1195                 1200             


Pro Leu  Leu Gly Asn Ser Thr  Gly Ile Asp Phe Gln  Asp Glu Leu 
    1205                 1210                 1215             


Asp Glu  Phe Phe Lys Asn Val  Ser Thr Ser Ile Pro  Asn Phe Gly 
    1220                 1225                 1230             


Ser Leu  Thr Gln Ile Asn Thr  Thr Leu Leu Asp Leu  Thr Tyr Glu 
    1235                 1240                 1245             


Met Leu  Ser Leu Gln Gln Val  Val Lys Ala Leu Asn  Glu Ser Tyr 
    1250                 1255                 1260             


Ile Asp  Leu Lys Glu Leu Gly  Asn Tyr Thr Tyr Tyr  Asn Lys Trp 
    1265                 1270                 1275             


Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala Gly Leu  Val Ala Leu 
    1280                 1285                 1290             


Ala Leu  Cys Val Phe Phe Ile  Leu Cys Cys Thr Gly  Cys Gly Thr 
    1295                 1300                 1305             


Asn Cys  Met Gly Lys Leu Lys  Cys Asn Arg Cys Cys  Asp Arg Tyr 
    1310                 1315                 1320             


Glu Glu  Tyr Asp Leu Glu Pro  His Lys Val His Val  His 
    1325                 1330                 1335     


<210>  116
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-SARS-COV-1 wtTMCT-AA

<400>  116

Trp Tyr Val Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Leu Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys 
            20                  25                  30          


Gly Ala Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser 
        35                  40                  45              


Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr 
    50                  55                  60  


<210>  117
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YQILSIYSTVASSLALAIMMAGLSLWMCSNGSLQCRICI

<400>  117

Trp Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
1               5                   10                  15      


Leu Ala Ile Met Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
            20                  25                  30          


Ser Leu Gln Cys Arg Ile Cys Ile 
        35                  40  


<210>  118
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-SARS-COV-1 H5iCT-AA

<400>  118

Trp Tyr Val Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Leu Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln 
            20                  25                  30          


Cys Arg Ile Cys Ile 
        35          


<210>  119
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-SARS-COV-1 H5iCT(V4)-AA

<400>  119

Trp Tyr Val Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Leu Leu Cys Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
            20                  25                  30          


Cys Ile 
        


<210>  120
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-SARS-COV-1 H1cCT-AA

<400>  120

Trp Tyr Val Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Leu Leu Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
            20                  25                  30          


Cys Arg Ile Cys Ile 
        35          


<210>  121
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-MERS-wtTMCT-AA

<400>  121

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Val Ala Leu Ala Leu 
1               5                   10                  15      


Cys Val Phe Phe Ile Leu Cys Cys Thr Gly Cys Gly Thr Asn Cys Met 
            20                  25                  30          


Gly Lys Leu Lys Cys Asn Arg Cys Cys Asp Arg Tyr Glu Glu Tyr Asp 
        35                  40                  45              


Leu Glu Pro His Lys Val His Val His 
    50                  55          


<210>  122
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-MERS-H5iTMCT-AA

<400>  122

Trp Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
1               5                   10                  15      


Leu Ala Ile Met Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
            20                  25                  30          


Ser Leu Gln Cys Arg Ile Cys Ile 
        35                  40  


<210>  123
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-MERS-H5iCT-AA

<400>  123

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Val Ala Leu Ala Leu 
1               5                   10                  15      


Cys Val Phe Phe Ile Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu 
            20                  25                  30          


Gln Cys Arg Ile Cys Ile 
        35              


<210>  124
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-MERS-H5iCT(V4)-AA

<400>  124

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Val Ala Leu Ala Leu 
1               5                   10                  15      


Cys Val Phe Phe Ile Leu Cys Cys Ser Asn Gly Ser Leu Gln Cys Arg 
            20                  25                  30          


Ile Cys Ile 
        35  


<210>  125
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-MERS-H1cCT-AA

<400>  125

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Val Ala Leu Ala Leu 
1               5                   10                  15      


Cys Val Phe Phe Ile Leu Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
            20                  25                  30          


Gln Cys Arg Ile Cys Ile 
        35              


<210>  126
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-S-protein+H1 Cal

<400>  126

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
            20                  25                  30          


Cys Arg Ile Cys Ile 
        35          


<210>  127
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-S-protein+H3 Minn

<400>  127

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Met Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys 
            20                  25                  30          


Asn Ile Cys Ile 
        35      


<210>  128
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-S-protein+H6 HK

<400>  128

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Gly Leu Trp Met Cys Ser Asn Gly Ser Met Gln 
            20                  25                  30          


Cys Arg Ile Cys Ile 
        35          


<210>  129
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-S-protein+H7 Guangdong

<400>  129

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Val Phe Ile Cys Val Lys Asn Gly Asn Met Arg 
            20                  25                  30          


Cys Thr Ile Cys Ile 
        35          


<210>  130
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-S-protein+H9 HK

<400>  130

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Leu Phe Trp Ala Met Ser Asn Gly Ser Cys Arg 
            20                  25                  30          


Cys Asn Ile Cys Ile 
        35          


<210>  131
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-S-protein+ B/ Wash

<400>  131

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Val Val Tyr Met Val Ser Arg Asp Asn Val Ser 
            20                  25                  30          


Cys Ser Ile Cys Leu 
        35          


<210>  132
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence of TM Domain of Coronavirus S-protein


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be present or absent

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  132

Trp Tyr Xaa Trp Leu Gly Phe Ile Ala Gly Leu Xaa Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Val Xaa Xaa Xaa Leu 
            20          


<210>  133
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence of TM Domain of Coronavirus S-protein


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa  may be Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa may be Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa may be Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa may be Leu or Met

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be Cys or absent

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa may be Phe or Thr

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa may be Phe or Ile

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  133

Trp Tyr Xaa Trp Leu Gly Phe Ile Ala Gly Leu Xaa Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Val Xaa Xaa Xaa Leu 
            20          


<210>  134
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM/CT Region of Modified SARS-CoV-1 S protein with intervening 
       peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X may be any combination of 0 to 10 amino acids.

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  134

Trp Tyr Val Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Leu Xaa Cys Ser Asn Gly Ser Xaa Xaa Cys Xaa Ile Cys 
            20                  25                  30          


Ile 
    


<210>  135
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM/CT Region of Modified MERS S protein with intervening peptide 
       sequence


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X may be any combination of 0 to 10 amino acids

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<400>  135

Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Val Ala Leu Ala Leu 
1               5                   10                  15      


Cys Val Phe Phe Ile Leu Xaa Cys Ser Asn Gly Ser Xaa Xaa Cys Xaa 
            20                  25                  30          


Ile Cys Ile 
        35  


<210>  136
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(AvB+wtCT-OC43).r

<400>  136
acgacacgac taaggccttc agtcgtcatg cgaggtctta atgacaagc                   49


<210>  137
<211>  4113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-OC43-wtTMCT-DNA

<400>  137
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgatcgg cgatctgaat tgtaccctgg atccccgcct gaaagggagc      120

tttaacaacc gagatacagg acccccgtct atatccatag atacagtgga tgttacgaac      180

gggctcggca cctactatgt gctagaccga gtttatttga acaccacctt attcctcaat      240

ggatactacc caacttcagg tagtacttac agaaacatgg cgctgaaggg tacggatctg      300

ctgagcaccc tatggtttaa acctcccttc ctctcggact ttattaatgg catcttcgct      360

aaggtgaaaa acacgaaggt tttcaaagat ggagtgatgt attcagagtt ccctgcgatc      420

accattggaa gtaccttcgt gaatacttcc tatagcgtgg tggttcaacc acggacaatc      480

aactccaccc aggacggcgt caacaagctc cagggattgc tggaggtgtc agtctgtcaa      540

tataacatgt gtgagtaccc acacactatc tgtcacccta atctaggcaa ccactttaag      600

gaactgtggc actacgatac gggggtggta agttgcttat ataagagaaa tttcacctat      660

gatgttaatg caacgtacct gtactttcac ttctatcaag aaggaggaac tttctacgca      720

tatttcacag ataccggctt tgtgacgaaa ttcttattca acgtttacct cggaatggca      780

ttaagccatt attacgtgat gcctctcact tgcatcagac gccctaagga tggtttttct      840

ctggagtact gggtcactcc cctgacacca cggcagtacc tgcttgcttt taaccaggac      900

ggtatcattt ttaatgccgt cgattgtatg agcgatttta tgagcgagat aaagtgcaag      960

acccaatcta ttgctccgcc cacgggggtg tacgaactga atggttacac cgtccagccc     1020

gttgccgatg tatatagacg gaaaccagac ctgcccaatt gcaacatcga agcttggtta     1080

aacgataagt cagtgccctc ccccctcaat tgggagagga agactttctc caactgtaat     1140

ttcaacatgt caagcctgat gtctttcatt caagccgatt cgttcacttg taataatata     1200

gatgcagcaa agatctatgg tatgtgcttc agttccatca caatagataa gtttgcaata     1260

ccaaaccgtc gcaaggtgga ccttcagctc ggcaacctgg gctatctgca gtccagcaat     1320

tatagaatag acaccaccgc cacatcatgt cagctgtact ataacctccc agcagcgaac     1380

gtcagtgtta gtaggttcaa tccttctacc tggaataaaa ggtttggatt catcgaagat     1440

agtgtgttcg tacctcagcc aacaggagtg ttcaccaatc acagcgtggt ctacgcccaa     1500

cattgcttca aggcacccaa aaatttctgc ccatgtagca gttgctcctg cccgggtaag     1560

aacaatggga tcggcacctg cccagcaggc accaattcac ttacatgcga taatctgtgt     1620

acactggatc ctattacact taaggcccct gatacctaca aatgccccca gagcaagagc     1680

ctggtcggta tcggagaaca ctgttccgga cttgcagtaa aaagcgacta ttgtggaaat     1740

aactcttgca cttgtcagcc acaagccttc ctcggttggt ccgctgactc ttgtttacaa     1800

ggggataagt gtaacatctt cgcaaatttc atcttacacg atgtgaataa cggcttaaca     1860

tgcagcacag atctccagaa ggcaaacaca gagatcgaat taggagtctg cgttaattac     1920

gatctctacg ggatctctgg ccagggcatc ttcgtggagg ttaatgctac ctactacaat     1980

agttggcaaa atctgctcta cgatagcaat ggcaacctct atggattcag agactatatt     2040

actaacagga cgttcatgat tcactcgtgc tattccgggc gggtgtcagc agcttatcac     2100

gcaaattctt cagagccagc tctgctattc cgaaacataa aatgtaatta cgtgttcaat     2160

aattcactga ctcggcagct gcagccgatt aattacagct tcgacagcta ccttggttgc     2220

gttgttaacg cctacaactc cactgccata tcagttcaga cctgcgacct tactgtgggc     2280

tctggctatt gtgtcgatta ttcaaagaac ggggggagcg ggtccgcaat aacaactggc     2340

tataggttca ccaattttga gcctttcacc gtgaatagtg tcaacgatag cctggagcct     2400

gtcggaggtc tttatgagat acaaatcccc tccgagttca caattggcaa catggaagag     2460

ttcatccaga cgagttcccc aaaggtgacg atcgattgcg cggctttcgt ctgcggcgac     2520

tacgccgcat gcaagttaca actcgttgag tatggaagtt tttgcgataa tataaacgca     2580

attctgactg aagtgaacga actgctggac accactcagt tgcaggtggc aaattcgctc     2640

atgaacggcg tgacactgtc aaccaaactg aaggacggtg tcaatttcaa tgtggatgac     2700

attaacttca gccccgtact gggctgtttg ggtagtgagt gttctaaggc tagcagccgc     2760

tccgccattg aggacttgtt gtttgataaa gttaagctga gtgacgttgg atttgttgag     2820

gcgtataata actgtaccgg tggtgcagag ataagggatc tgatctgtgt ccagagttat     2880

aaggggatta aggttctccc cccgctactc tcggagaatc agatatcagg atacaccctg     2940

gccgctacct cagcctcgct gtttccccct tggaccgctg ccgccggtgt cccattttat     3000

ttgaatgtgc agtatcggat caacggtctg ggagtgacaa tggacgtgct gtctcagaac     3060

cagaaactga tcgccaatgc attcaacaat gctctgcacg ccatccagca agggtttgac     3120

gctacaaatt ctgccctcgt aaaaatccag gccgtggtga atgctaacgc cgaagccctt     3180

aataatctgc tccagcagct ttctaaccgc tttggagcta tttctgcctc actgcaggaa     3240

attctatcca gactggatcc ccctgaggca gaagcccaaa tcgaccgtct cataaacggc     3300

agactcactg ctcttaacgc ctacgttagt caacaattga gcgattcgac cttggtgaaa     3360

ttcagcgcag ctcaggctat ggagaaggtg aacgagtgcg tgaagtcaca gagctccaga     3420

atcaatttct gtggcaatgg gaaccatatc atctccttgg ttcagaatgc tccctacggc     3480

ctgtatttca tccacttcaa ctacgtgccc acgaagtacg ttacagccaa agtgtccccc     3540

ggactgtgca tcgctggtaa caggggcatt gcaccaaaat ccggctactt cgtcaatgtc     3600

aacaacacat ggatgtatac tgggagtggt tattattacc ctgaacctat aacagagaac     3660

aatgtagtag tcatgtccac atgcgccgtc aattatacta aggcccccta tgttatgctc     3720

aacacttcaa ttcccaatct cccggatttc aaagaagagc tggatcagtg gtttaagaat     3780

cagacatccg tggcccctga cttaagcttg gattatatca atgtgacttt tttagactta     3840

caggtcgaga tgaaccgact ccaggaagct ataaaagtac tgaaccactc ctatatcaat     3900

ctgaaagata tcggtacata cgaatattac gtaaaatggc cttggtatgt gtggctacta     3960

atttgccttg cgggcgtggc tatgctggtc ctgctgttct tcatttgctg ctgtactggg     4020

tgcggtactt cctgcttcaa aaagtgcggt ggttgctgcg acgactacac tgggtaccag     4080

gagcttgtca ttaagacctc gcatgacgac tga                                  4113


<210>  138
<211>  4065
<212>  DNA
<213>  Artificial  Sequence

<220>
<223>  PDI-OC43-H5iTMCT-DNA

<400>  138
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgatcgg cgatctgaat tgtaccctgg atccccgcct gaaagggagc      120

tttaacaacc gagatacagg acccccgtct atatccatag atacagtgga tgttacgaac      180

gggctcggca cctactatgt gctagaccga gtttatttga acaccacctt attcctcaat      240

ggatactacc caacttcagg tagtacttac agaaacatgg cgctgaaggg tacggatctg      300

ctgagcaccc tatggtttaa acctcccttc ctctcggact ttattaatgg catcttcgct      360

aaggtgaaaa acacgaaggt tttcaaagat ggagtgatgt attcagagtt ccctgcgatc      420

accattggaa gtaccttcgt gaatacttcc tatagcgtgg tggttcaacc acggacaatc      480

aactccaccc aggacggcgt caacaagctc cagggattgc tggaggtgtc agtctgtcaa      540

tataacatgt gtgagtaccc acacactatc tgtcacccta atctaggcaa ccactttaag      600

gaactgtggc actacgatac gggggtggta agttgcttat ataagagaaa tttcacctat      660

gatgttaatg caacgtacct gtactttcac ttctatcaag aaggaggaac tttctacgca      720

tatttcacag ataccggctt tgtgacgaaa ttcttattca acgtttacct cggaatggca      780

ttaagccatt attacgtgat gcctctcact tgcatcagac gccctaagga tggtttttct      840

ctggagtact gggtcactcc cctgacacca cggcagtacc tgcttgcttt taaccaggac      900

ggtatcattt ttaatgccgt cgattgtatg agcgatttta tgagcgagat aaagtgcaag      960

acccaatcta ttgctccgcc cacgggggtg tacgaactga atggttacac cgtccagccc     1020

gttgccgatg tatatagacg gaaaccagac ctgcccaatt gcaacatcga agcttggtta     1080

aacgataagt cagtgccctc ccccctcaat tgggagagga agactttctc caactgtaat     1140

ttcaacatgt caagcctgat gtctttcatt caagccgatt cgttcacttg taataatata     1200

gatgcagcaa agatctatgg tatgtgcttc agttccatca caatagataa gtttgcaata     1260

ccaaaccgtc gcaaggtgga ccttcagctc ggcaacctgg gctatctgca gtccagcaat     1320

tatagaatag acaccaccgc cacatcatgt cagctgtact ataacctccc agcagcgaac     1380

gtcagtgtta gtaggttcaa tccttctacc tggaataaaa ggtttggatt catcgaagat     1440

agtgtgttcg tacctcagcc aacaggagtg ttcaccaatc acagcgtggt ctacgcccaa     1500

cattgcttca aggcacccaa aaatttctgc ccatgtagca gttgctcctg cccgggtaag     1560

aacaatggga tcggcacctg cccagcaggc accaattcac ttacatgcga taatctgtgt     1620

acactggatc ctattacact taaggcccct gatacctaca aatgccccca gagcaagagc     1680

ctggtcggta tcggagaaca ctgttccgga cttgcagtaa aaagcgacta ttgtggaaat     1740

aactcttgca cttgtcagcc acaagccttc ctcggttggt ccgctgactc ttgtttacaa     1800

ggggataagt gtaacatctt cgcaaatttc atcttacacg atgtgaataa cggcttaaca     1860

tgcagcacag atctccagaa ggcaaacaca gagatcgaat taggagtctg cgttaattac     1920

gatctctacg ggatctctgg ccagggcatc ttcgtggagg ttaatgctac ctactacaat     1980

agttggcaaa atctgctcta cgatagcaat ggcaacctct atggattcag agactatatt     2040

actaacagga cgttcatgat tcactcgtgc tattccgggc gggtgtcagc agcttatcac     2100

gcaaattctt cagagccagc tctgctattc cgaaacataa aatgtaatta cgtgttcaat     2160

aattcactga ctcggcagct gcagccgatt aattacagct tcgacagcta ccttggttgc     2220

gttgttaacg cctacaactc cactgccata tcagttcaga cctgcgacct tactgtgggc     2280

tctggctatt gtgtcgatta ttcaaagaac ggggggagcg ggtccgcaat aacaactggc     2340

tataggttca ccaattttga gcctttcacc gtgaatagtg tcaacgatag cctggagcct     2400

gtcggaggtc tttatgagat acaaatcccc tccgagttca caattggcaa catggaagag     2460

ttcatccaga cgagttcccc aaaggtgacg atcgattgcg cggctttcgt ctgcggcgac     2520

tacgccgcat gcaagttaca actcgttgag tatggaagtt tttgcgataa tataaacgca     2580

attctgactg aagtgaacga actgctggac accactcagt tgcaggtggc aaattcgctc     2640

atgaacggcg tgacactgtc aaccaaactg aaggacggtg tcaatttcaa tgtggatgac     2700

attaacttca gccccgtact gggctgtttg ggtagtgagt gttctaaggc tagcagccgc     2760

tccgccattg aggacttgtt gtttgataaa gttaagctga gtgacgttgg atttgttgag     2820

gcgtataata actgtaccgg tggtgcagag ataagggatc tgatctgtgt ccagagttat     2880

aaggggatta aggttctccc cccgctactc tcggagaatc agatatcagg atacaccctg     2940

gccgctacct cagcctcgct gtttccccct tggaccgctg ccgccggtgt cccattttat     3000

ttgaatgtgc agtatcggat caacggtctg ggagtgacaa tggacgtgct gtctcagaac     3060

cagaaactga tcgccaatgc attcaacaat gctctgcacg ccatccagca agggtttgac     3120

gctacaaatt ctgccctcgt aaaaatccag gccgtggtga atgctaacgc cgaagccctt     3180

aataatctgc tccagcagct ttctaaccgc tttggagcta tttctgcctc actgcaggaa     3240

attctatcca gactggatcc ccctgaggca gaagcccaaa tcgaccgtct cataaacggc     3300

agactcactg ctcttaacgc ctacgttagt caacaattga gcgattcgac cttggtgaaa     3360

ttcagcgcag ctcaggctat ggagaaggtg aacgagtgcg tgaagtcaca gagctccaga     3420

atcaatttct gtggcaatgg gaaccatatc atctccttgg ttcagaatgc tccctacggc     3480

ctgtatttca tccacttcaa ctacgtgccc acgaagtacg ttacagccaa agtgtccccc     3540

ggactgtgca tcgctggtaa caggggcatt gcaccaaaat ccggctactt cgtcaatgtc     3600

aacaacacat ggatgtatac tgggagtggt tattattacc ctgaacctat aacagagaac     3660

aatgtagtag tcatgtccac atgcgccgtc aattatacta aggcccccta tgttatgctc     3720

aacacttcaa ttcccaatct cccggatttc aaagaagagc tggatcagtg gtttaagaat     3780

cagacatccg tggcccctga cttaagcttg gattatatca atgtgacttt tttagactta     3840

caggtcgaga tgaaccgact ccaggaagct ataaaagtac tgaaccactc ctatatcaat     3900

ctgaaagata tcggtacata cgaatattac gtaaaatggc cttggtatca aatactgtca     3960

atttattcaa cagtggcgag ttccctagca ctggcaatca tgatggctgg tctatcttta     4020

tggatgtgct ccaatggatc gttacaatgc agaatttgca tttga                     4065


<210>  139
<211>  4056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-OC43-H5iCT-DNA

<400>  139
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgatcgg cgatctgaat tgtaccctgg atccccgcct gaaagggagc      120

tttaacaacc gagatacagg acccccgtct atatccatag atacagtgga tgttacgaac      180

gggctcggca cctactatgt gctagaccga gtttatttga acaccacctt attcctcaat      240

ggatactacc caacttcagg tagtacttac agaaacatgg cgctgaaggg tacggatctg      300

ctgagcaccc tatggtttaa acctcccttc ctctcggact ttattaatgg catcttcgct      360

aaggtgaaaa acacgaaggt tttcaaagat ggagtgatgt attcagagtt ccctgcgatc      420

accattggaa gtaccttcgt gaatacttcc tatagcgtgg tggttcaacc acggacaatc      480

aactccaccc aggacggcgt caacaagctc cagggattgc tggaggtgtc agtctgtcaa      540

tataacatgt gtgagtaccc acacactatc tgtcacccta atctaggcaa ccactttaag      600

gaactgtggc actacgatac gggggtggta agttgcttat ataagagaaa tttcacctat      660

gatgttaatg caacgtacct gtactttcac ttctatcaag aaggaggaac tttctacgca      720

tatttcacag ataccggctt tgtgacgaaa ttcttattca acgtttacct cggaatggca      780

ttaagccatt attacgtgat gcctctcact tgcatcagac gccctaagga tggtttttct      840

ctggagtact gggtcactcc cctgacacca cggcagtacc tgcttgcttt taaccaggac      900

ggtatcattt ttaatgccgt cgattgtatg agcgatttta tgagcgagat aaagtgcaag      960

acccaatcta ttgctccgcc cacgggggtg tacgaactga atggttacac cgtccagccc     1020

gttgccgatg tatatagacg gaaaccagac ctgcccaatt gcaacatcga agcttggtta     1080

aacgataagt cagtgccctc ccccctcaat tgggagagga agactttctc caactgtaat     1140

ttcaacatgt caagcctgat gtctttcatt caagccgatt cgttcacttg taataatata     1200

gatgcagcaa agatctatgg tatgtgcttc agttccatca caatagataa gtttgcaata     1260

ccaaaccgtc gcaaggtgga ccttcagctc ggcaacctgg gctatctgca gtccagcaat     1320

tatagaatag acaccaccgc cacatcatgt cagctgtact ataacctccc agcagcgaac     1380

gtcagtgtta gtaggttcaa tccttctacc tggaataaaa ggtttggatt catcgaagat     1440

agtgtgttcg tacctcagcc aacaggagtg ttcaccaatc acagcgtggt ctacgcccaa     1500

cattgcttca aggcacccaa aaatttctgc ccatgtagca gttgctcctg cccgggtaag     1560

aacaatggga tcggcacctg cccagcaggc accaattcac ttacatgcga taatctgtgt     1620

acactggatc ctattacact taaggcccct gatacctaca aatgccccca gagcaagagc     1680

ctggtcggta tcggagaaca ctgttccgga cttgcagtaa aaagcgacta ttgtggaaat     1740

aactcttgca cttgtcagcc acaagccttc ctcggttggt ccgctgactc ttgtttacaa     1800

ggggataagt gtaacatctt cgcaaatttc atcttacacg atgtgaataa cggcttaaca     1860

tgcagcacag atctccagaa ggcaaacaca gagatcgaat taggagtctg cgttaattac     1920

gatctctacg ggatctctgg ccagggcatc ttcgtggagg ttaatgctac ctactacaat     1980

agttggcaaa atctgctcta cgatagcaat ggcaacctct atggattcag agactatatt     2040

actaacagga cgttcatgat tcactcgtgc tattccgggc gggtgtcagc agcttatcac     2100

gcaaattctt cagagccagc tctgctattc cgaaacataa aatgtaatta cgtgttcaat     2160

aattcactga ctcggcagct gcagccgatt aattacagct tcgacagcta ccttggttgc     2220

gttgttaacg cctacaactc cactgccata tcagttcaga cctgcgacct tactgtgggc     2280

tctggctatt gtgtcgatta ttcaaagaac ggggggagcg ggtccgcaat aacaactggc     2340

tataggttca ccaattttga gcctttcacc gtgaatagtg tcaacgatag cctggagcct     2400

gtcggaggtc tttatgagat acaaatcccc tccgagttca caattggcaa catggaagag     2460

ttcatccaga cgagttcccc aaaggtgacg atcgattgcg cggctttcgt ctgcggcgac     2520

tacgccgcat gcaagttaca actcgttgag tatggaagtt tttgcgataa tataaacgca     2580

attctgactg aagtgaacga actgctggac accactcagt tgcaggtggc aaattcgctc     2640

atgaacggcg tgacactgtc aaccaaactg aaggacggtg tcaatttcaa tgtggatgac     2700

attaacttca gccccgtact gggctgtttg ggtagtgagt gttctaaggc tagcagccgc     2760

tccgccattg aggacttgtt gtttgataaa gttaagctga gtgacgttgg atttgttgag     2820

gcgtataata actgtaccgg tggtgcagag ataagggatc tgatctgtgt ccagagttat     2880

aaggggatta aggttctccc cccgctactc tcggagaatc agatatcagg atacaccctg     2940

gccgctacct cagcctcgct gtttccccct tggaccgctg ccgccggtgt cccattttat     3000

ttgaatgtgc agtatcggat caacggtctg ggagtgacaa tggacgtgct gtctcagaac     3060

cagaaactga tcgccaatgc attcaacaat gctctgcacg ccatccagca agggtttgac     3120

gctacaaatt ctgccctcgt aaaaatccag gccgtggtga atgctaacgc cgaagccctt     3180

aataatctgc tccagcagct ttctaaccgc tttggagcta tttctgcctc actgcaggaa     3240

attctatcca gactggatcc ccctgaggca gaagcccaaa tcgaccgtct cataaacggc     3300

agactcactg ctcttaacgc ctacgttagt caacaattga gcgattcgac cttggtgaaa     3360

ttcagcgcag ctcaggctat ggagaaggtg aacgagtgcg tgaagtcaca gagctccaga     3420

atcaatttct gtggcaatgg gaaccatatc atctccttgg ttcagaatgc tccctacggc     3480

ctgtatttca tccacttcaa ctacgtgccc acgaagtacg ttacagccaa agtgtccccc     3540

ggactgtgca tcgctggtaa caggggcatt gcaccaaaat ccggctactt cgtcaatgtc     3600

aacaacacat ggatgtatac tgggagtggt tattattacc ctgaacctat aacagagaac     3660

aatgtagtag tcatgtccac atgcgccgtc aattatacta aggcccccta tgttatgctc     3720

aacacttcaa ttcccaatct cccggatttc aaagaagagc tggatcagtg gtttaagaat     3780

cagacatccg tggcccctga cttaagcttg gattatatca atgtgacttt tttagactta     3840

caggtcgaga tgaaccgact ccaggaagct ataaaagtac tgaaccactc ctatatcaat     3900

ctgaaagata tcggtacata cgaatattac gtaaaatggc cttggtatgt gtggctacta     3960

atttgccttg cgggcgtggc tatgctggtc ctgctgttct tcatttcttt atggatgtgc     4020

tccaatggat cgttacaatg cagaatttgc atttga                               4056


<210>  140
<211>  4047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-OC43-H5iCT(V4)-DNA

<400>  140
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgatcgg cgatctgaat tgtaccctgg atccccgcct gaaagggagc      120

tttaacaacc gagatacagg acccccgtct atatccatag atacagtgga tgttacgaac      180

gggctcggca cctactatgt gctagaccga gtttatttga acaccacctt attcctcaat      240

ggatactacc caacttcagg tagtacttac agaaacatgg cgctgaaggg tacggatctg      300

ctgagcaccc tatggtttaa acctcccttc ctctcggact ttattaatgg catcttcgct      360

aaggtgaaaa acacgaaggt tttcaaagat ggagtgatgt attcagagtt ccctgcgatc      420

accattggaa gtaccttcgt gaatacttcc tatagcgtgg tggttcaacc acggacaatc      480

aactccaccc aggacggcgt caacaagctc cagggattgc tggaggtgtc agtctgtcaa      540

tataacatgt gtgagtaccc acacactatc tgtcacccta atctaggcaa ccactttaag      600

gaactgtggc actacgatac gggggtggta agttgcttat ataagagaaa tttcacctat      660

gatgttaatg caacgtacct gtactttcac ttctatcaag aaggaggaac tttctacgca      720

tatttcacag ataccggctt tgtgacgaaa ttcttattca acgtttacct cggaatggca      780

ttaagccatt attacgtgat gcctctcact tgcatcagac gccctaagga tggtttttct      840

ctggagtact gggtcactcc cctgacacca cggcagtacc tgcttgcttt taaccaggac      900

ggtatcattt ttaatgccgt cgattgtatg agcgatttta tgagcgagat aaagtgcaag      960

acccaatcta ttgctccgcc cacgggggtg tacgaactga atggttacac cgtccagccc     1020

gttgccgatg tatatagacg gaaaccagac ctgcccaatt gcaacatcga agcttggtta     1080

aacgataagt cagtgccctc ccccctcaat tgggagagga agactttctc caactgtaat     1140

ttcaacatgt caagcctgat gtctttcatt caagccgatt cgttcacttg taataatata     1200

gatgcagcaa agatctatgg tatgtgcttc agttccatca caatagataa gtttgcaata     1260

ccaaaccgtc gcaaggtgga ccttcagctc ggcaacctgg gctatctgca gtccagcaat     1320

tatagaatag acaccaccgc cacatcatgt cagctgtact ataacctccc agcagcgaac     1380

gtcagtgtta gtaggttcaa tccttctacc tggaataaaa ggtttggatt catcgaagat     1440

agtgtgttcg tacctcagcc aacaggagtg ttcaccaatc acagcgtggt ctacgcccaa     1500

cattgcttca aggcacccaa aaatttctgc ccatgtagca gttgctcctg cccgggtaag     1560

aacaatggga tcggcacctg cccagcaggc accaattcac ttacatgcga taatctgtgt     1620

acactggatc ctattacact taaggcccct gatacctaca aatgccccca gagcaagagc     1680

ctggtcggta tcggagaaca ctgttccgga cttgcagtaa aaagcgacta ttgtggaaat     1740

aactcttgca cttgtcagcc acaagccttc ctcggttggt ccgctgactc ttgtttacaa     1800

ggggataagt gtaacatctt cgcaaatttc atcttacacg atgtgaataa cggcttaaca     1860

tgcagcacag atctccagaa ggcaaacaca gagatcgaat taggagtctg cgttaattac     1920

gatctctacg ggatctctgg ccagggcatc ttcgtggagg ttaatgctac ctactacaat     1980

agttggcaaa atctgctcta cgatagcaat ggcaacctct atggattcag agactatatt     2040

actaacagga cgttcatgat tcactcgtgc tattccgggc gggtgtcagc agcttatcac     2100

gcaaattctt cagagccagc tctgctattc cgaaacataa aatgtaatta cgtgttcaat     2160

aattcactga ctcggcagct gcagccgatt aattacagct tcgacagcta ccttggttgc     2220

gttgttaacg cctacaactc cactgccata tcagttcaga cctgcgacct tactgtgggc     2280

tctggctatt gtgtcgatta ttcaaagaac ggggggagcg ggtccgcaat aacaactggc     2340

tataggttca ccaattttga gcctttcacc gtgaatagtg tcaacgatag cctggagcct     2400

gtcggaggtc tttatgagat acaaatcccc tccgagttca caattggcaa catggaagag     2460

ttcatccaga cgagttcccc aaaggtgacg atcgattgcg cggctttcgt ctgcggcgac     2520

tacgccgcat gcaagttaca actcgttgag tatggaagtt tttgcgataa tataaacgca     2580

attctgactg aagtgaacga actgctggac accactcagt tgcaggtggc aaattcgctc     2640

atgaacggcg tgacactgtc aaccaaactg aaggacggtg tcaatttcaa tgtggatgac     2700

attaacttca gccccgtact gggctgtttg ggtagtgagt gttctaaggc tagcagccgc     2760

tccgccattg aggacttgtt gtttgataaa gttaagctga gtgacgttgg atttgttgag     2820

gcgtataata actgtaccgg tggtgcagag ataagggatc tgatctgtgt ccagagttat     2880

aaggggatta aggttctccc cccgctactc tcggagaatc agatatcagg atacaccctg     2940

gccgctacct cagcctcgct gtttccccct tggaccgctg ccgccggtgt cccattttat     3000

ttgaatgtgc agtatcggat caacggtctg ggagtgacaa tggacgtgct gtctcagaac     3060

cagaaactga tcgccaatgc attcaacaat gctctgcacg ccatccagca agggtttgac     3120

gctacaaatt ctgccctcgt aaaaatccag gccgtggtga atgctaacgc cgaagccctt     3180

aataatctgc tccagcagct ttctaaccgc tttggagcta tttctgcctc actgcaggaa     3240

attctatcca gactggatcc ccctgaggca gaagcccaaa tcgaccgtct cataaacggc     3300

agactcactg ctcttaacgc ctacgttagt caacaattga gcgattcgac cttggtgaaa     3360

ttcagcgcag ctcaggctat ggagaaggtg aacgagtgcg tgaagtcaca gagctccaga     3420

atcaatttct gtggcaatgg gaaccatatc atctccttgg ttcagaatgc tccctacggc     3480

ctgtatttca tccacttcaa ctacgtgccc acgaagtacg ttacagccaa agtgtccccc     3540

ggactgtgca tcgctggtaa caggggcatt gcaccaaaat ccggctactt cgtcaatgtc     3600

aacaacacat ggatgtatac tgggagtggt tattattacc ctgaacctat aacagagaac     3660

aatgtagtag tcatgtccac atgcgccgtc aattatacta aggcccccta tgttatgctc     3720

aacacttcaa ttcccaatct cccggatttc aaagaagagc tggatcagtg gtttaagaat     3780

cagacatccg tggcccctga cttaagcttg gattatatca atgtgacttt tttagactta     3840

caggtcgaga tgaaccgact ccaggaagct ataaaagtac tgaaccactc ctatatcaat     3900

ctgaaagata tcggtacata cgaatattac gtaaaatggc cttggtatgt gtggctacta     3960

atttgccttg cgggcgtggc tatgctggtc ctgctgttct tcatttgctg ctccaatgga     4020

tcgttacaat gcagaatttg catttga                                         4047


<210>  141
<211>  4056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-OC43-H1cCT-DNA

<400>  141
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggtgatcgg cgatctgaat tgtaccctgg atccccgcct gaaagggagc      120

tttaacaacc gagatacagg acccccgtct atatccatag atacagtgga tgttacgaac      180

gggctcggca cctactatgt gctagaccga gtttatttga acaccacctt attcctcaat      240

ggatactacc caacttcagg tagtacttac agaaacatgg cgctgaaggg tacggatctg      300

ctgagcaccc tatggtttaa acctcccttc ctctcggact ttattaatgg catcttcgct      360

aaggtgaaaa acacgaaggt tttcaaagat ggagtgatgt attcagagtt ccctgcgatc      420

accattggaa gtaccttcgt gaatacttcc tatagcgtgg tggttcaacc acggacaatc      480

aactccaccc aggacggcgt caacaagctc cagggattgc tggaggtgtc agtctgtcaa      540

tataacatgt gtgagtaccc acacactatc tgtcacccta atctaggcaa ccactttaag      600

gaactgtggc actacgatac gggggtggta agttgcttat ataagagaaa tttcacctat      660

gatgttaatg caacgtacct gtactttcac ttctatcaag aaggaggaac tttctacgca      720

tatttcacag ataccggctt tgtgacgaaa ttcttattca acgtttacct cggaatggca      780

ttaagccatt attacgtgat gcctctcact tgcatcagac gccctaagga tggtttttct      840

ctggagtact gggtcactcc cctgacacca cggcagtacc tgcttgcttt taaccaggac      900

ggtatcattt ttaatgccgt cgattgtatg agcgatttta tgagcgagat aaagtgcaag      960

acccaatcta ttgctccgcc cacgggggtg tacgaactga atggttacac cgtccagccc     1020

gttgccgatg tatatagacg gaaaccagac ctgcccaatt gcaacatcga agcttggtta     1080

aacgataagt cagtgccctc ccccctcaat tgggagagga agactttctc caactgtaat     1140

ttcaacatgt caagcctgat gtctttcatt caagccgatt cgttcacttg taataatata     1200

gatgcagcaa agatctatgg tatgtgcttc agttccatca caatagataa gtttgcaata     1260

ccaaaccgtc gcaaggtgga ccttcagctc ggcaacctgg gctatctgca gtccagcaat     1320

tatagaatag acaccaccgc cacatcatgt cagctgtact ataacctccc agcagcgaac     1380

gtcagtgtta gtaggttcaa tccttctacc tggaataaaa ggtttggatt catcgaagat     1440

agtgtgttcg tacctcagcc aacaggagtg ttcaccaatc acagcgtggt ctacgcccaa     1500

cattgcttca aggcacccaa aaatttctgc ccatgtagca gttgctcctg cccgggtaag     1560

aacaatggga tcggcacctg cccagcaggc accaattcac ttacatgcga taatctgtgt     1620

acactggatc ctattacact taaggcccct gatacctaca aatgccccca gagcaagagc     1680

ctggtcggta tcggagaaca ctgttccgga cttgcagtaa aaagcgacta ttgtggaaat     1740

aactcttgca cttgtcagcc acaagccttc ctcggttggt ccgctgactc ttgtttacaa     1800

ggggataagt gtaacatctt cgcaaatttc atcttacacg atgtgaataa cggcttaaca     1860

tgcagcacag atctccagaa ggcaaacaca gagatcgaat taggagtctg cgttaattac     1920

gatctctacg ggatctctgg ccagggcatc ttcgtggagg ttaatgctac ctactacaat     1980

agttggcaaa atctgctcta cgatagcaat ggcaacctct atggattcag agactatatt     2040

actaacagga cgttcatgat tcactcgtgc tattccgggc gggtgtcagc agcttatcac     2100

gcaaattctt cagagccagc tctgctattc cgaaacataa aatgtaatta cgtgttcaat     2160

aattcactga ctcggcagct gcagccgatt aattacagct tcgacagcta ccttggttgc     2220

gttgttaacg cctacaactc cactgccata tcagttcaga cctgcgacct tactgtgggc     2280

tctggctatt gtgtcgatta ttcaaagaac ggggggagcg ggtccgcaat aacaactggc     2340

tataggttca ccaattttga gcctttcacc gtgaatagtg tcaacgatag cctggagcct     2400

gtcggaggtc tttatgagat acaaatcccc tccgagttca caattggcaa catggaagag     2460

ttcatccaga cgagttcccc aaaggtgacg atcgattgcg cggctttcgt ctgcggcgac     2520

tacgccgcat gcaagttaca actcgttgag tatggaagtt tttgcgataa tataaacgca     2580

attctgactg aagtgaacga actgctggac accactcagt tgcaggtggc aaattcgctc     2640

atgaacggcg tgacactgtc aaccaaactg aaggacggtg tcaatttcaa tgtggatgac     2700

attaacttca gccccgtact gggctgtttg ggtagtgagt gttctaaggc tagcagccgc     2760

tccgccattg aggacttgtt gtttgataaa gttaagctga gtgacgttgg atttgttgag     2820

gcgtataata actgtaccgg tggtgcagag ataagggatc tgatctgtgt ccagagttat     2880

aaggggatta aggttctccc cccgctactc tcggagaatc agatatcagg atacaccctg     2940

gccgctacct cagcctcgct gtttccccct tggaccgctg ccgccggtgt cccattttat     3000

ttgaatgtgc agtatcggat caacggtctg ggagtgacaa tggacgtgct gtctcagaac     3060

cagaaactga tcgccaatgc attcaacaat gctctgcacg ccatccagca agggtttgac     3120

gctacaaatt ctgccctcgt aaaaatccag gccgtggtga atgctaacgc cgaagccctt     3180

aataatctgc tccagcagct ttctaaccgc tttggagcta tttctgcctc actgcaggaa     3240

attctatcca gactggatcc ccctgaggca gaagcccaaa tcgaccgtct cataaacggc     3300

agactcactg ctcttaacgc ctacgttagt caacaattga gcgattcgac cttggtgaaa     3360

ttcagcgcag ctcaggctat ggagaaggtg aacgagtgcg tgaagtcaca gagctccaga     3420

atcaatttct gtggcaatgg gaaccatatc atctccttgg ttcagaatgc tccctacggc     3480

ctgtatttca tccacttcaa ctacgtgccc acgaagtacg ttacagccaa agtgtccccc     3540

ggactgtgca tcgctggtaa caggggcatt gcaccaaaat ccggctactt cgtcaatgtc     3600

aacaacacat ggatgtatac tgggagtggt tattattacc ctgaacctat aacagagaac     3660

aatgtagtag tcatgtccac atgcgccgtc aattatacta aggcccccta tgttatgctc     3720

aacacttcaa ttcccaatct cccggatttc aaagaagagc tggatcagtg gtttaagaat     3780

cagacatccg tggcccctga cttaagcttg gattatatca atgtgacttt tttagactta     3840

caggtcgaga tgaaccgact ccaggaagct ataaaagtac tgaaccactc ctatatcaat     3900

ctgaaagata tcggtacata cgaatattac gtaaaatggc cttggtatgt gtggctacta     3960

atttgccttg cgggcgtggc tatgctggtc ctgctgttct tcattagctt ctggatgtgc     4020

tctaatgggt ctctacagtg tagaatatgt atttga                               4056


<210>  142
<211>  1370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-OC43-wtTMCT-AA

<400>  142

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Ile Gly Asp Leu Asn Cys Thr 
            20                  25                  30          


Leu Asp Pro Arg Leu Lys Gly Ser Phe Asn Asn Arg Asp Thr Gly Pro 
        35                  40                  45              


Pro Ser Ile Ser Ile Asp Thr Val Asp Val Thr Asn Gly Leu Gly Thr 
    50                  55                  60                  


Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr Leu Phe Leu Asn 
65                  70                  75                  80  


Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn Met Ala Leu Lys 
                85                  90                  95      


Gly Thr Asp Leu Leu Ser Thr Leu Trp Phe Lys Pro Pro Phe Leu Ser 
            100                 105                 110         


Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn Thr Lys Val Phe 
        115                 120                 125             


Lys Asp Gly Val Met Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly Ser 
    130                 135                 140                 


Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln Pro Arg Thr Ile 
145                 150                 155                 160 


Asn Ser Thr Gln Asp Gly Val Asn Lys Leu Gln Gly Leu Leu Glu Val 
                165                 170                 175     


Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro His Thr Ile Cys His 
            180                 185                 190         


Pro Asn Leu Gly Asn His Phe Lys Glu Leu Trp His Tyr Asp Thr Gly 
        195                 200                 205             


Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr Asp Val Asn Ala 
    210                 215                 220                 


Thr Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr Ala 
225                 230                 235                 240 


Tyr Phe Thr Asp Thr Gly Phe Val Thr Lys Phe Leu Phe Asn Val Tyr 
                245                 250                 255     


Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro Leu Thr Cys Ile 
            260                 265                 270         


Arg Arg Pro Lys Asp Gly Phe Ser Leu Glu Tyr Trp Val Thr Pro Leu 
        275                 280                 285             


Thr Pro Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
    290                 295                 300                 


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
305                 310                 315                 320 


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
                325                 330                 335     


Thr Val Gln Pro Val Ala Asp Val Tyr Arg Arg Lys Pro Asp Leu Pro 
            340                 345                 350         


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
        355                 360                 365             


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
    370                 375                 380                 


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
385                 390                 395                 400 


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
                405                 410                 415     


Lys Phe Ala Ile Pro Asn Arg Arg Lys Val Asp Leu Gln Leu Gly Asn 
            420                 425                 430         


Leu Gly Tyr Leu Gln Ser Ser Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
        435                 440                 445             


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
    450                 455                 460                 


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
465                 470                 475                 480 


Ser Val Phe Val Pro Gln Pro Thr Gly Val Phe Thr Asn His Ser Val 
                485                 490                 495     


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
            500                 505                 510         


Ser Ser Cys Ser Cys Pro Gly Lys Asn Asn Gly Ile Gly Thr Cys Pro 
        515                 520                 525             


Ala Gly Thr Asn Ser Leu Thr Cys Asp Asn Leu Cys Thr Leu Asp Pro 
    530                 535                 540                 


Ile Thr Leu Lys Ala Pro Asp Thr Tyr Lys Cys Pro Gln Ser Lys Ser 
545                 550                 555                 560 


Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val Lys Ser Asp 
                565                 570                 575     


Tyr Cys Gly Asn Asn Ser Cys Thr Cys Gln Pro Gln Ala Phe Leu Gly 
            580                 585                 590         


Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn Ile Phe Ala 
        595                 600                 605             


Asn Phe Ile Leu His Asp Val Asn Asn Gly Leu Thr Cys Ser Thr Asp 
    610                 615                 620                 


Leu Gln Lys Ala Asn Thr Glu Ile Glu Leu Gly Val Cys Val Asn Tyr 
625                 630                 635                 640 


Asp Leu Tyr Gly Ile Ser Gly Gln Gly Ile Phe Val Glu Val Asn Ala 
                645                 650                 655     


Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn 
            660                 665                 670         


Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe Met Ile His 
        675                 680                 685             


Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Tyr His Ala Asn Ser Ser 
    690                 695                 700                 


Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr Val Phe Asn 
705                 710                 715                 720 


Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Ser Phe Asp Ser 
                725                 730                 735     


Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile Ser Val 
            740                 745                 750         


Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp Tyr Ser 
        755                 760                 765             


Lys Asn Gly Gly Ser Gly Ser Ala Ile Thr Thr Gly Tyr Arg Phe Thr 
    770                 775                 780                 


Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu Glu Pro 
785                 790                 795                 800 


Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr Ile Gly 
                805                 810                 815     


Asn Met Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
            820                 825                 830         


Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Leu Gln Leu 
        835                 840                 845             


Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu Thr Glu 
    850                 855                 860                 


Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn Ser Leu 
865                 870                 875                 880 


Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val Asn Phe 
                885                 890                 895     


Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu Gly Ser 
            900                 905                 910         


Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu Leu Phe 
        915                 920                 925             


Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn 
    930                 935                 940                 


Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln Ser Tyr 
945                 950                 955                 960 


Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln Ile Ser 
                965                 970                 975     


Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro Trp Thr 
            980                 985                 990         


Ala Ala Ala Gly Val Pro Phe Tyr  Leu Asn Val Gln Tyr  Arg Ile Asn 
        995                 1000                 1005             


Gly Leu  Gly Val Thr Met Asp  Val Leu Ser Gln Asn  Gln Lys Leu 
    1010                 1015                 1020             


Ile Ala  Asn Ala Phe Asn Asn  Ala Leu His Ala Ile  Gln Gln Gly 
    1025                 1030                 1035             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1040                 1045                 1050             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1055                 1060                 1065             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1070                 1075                 1080             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1085                 1090                 1095             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1100                 1105                 1110             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1115                 1120                 1125             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1130                 1135                 1140             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1145                 1150                 1155             


Tyr Gly  Leu Tyr Phe Ile His  Phe Asn Tyr Val Pro  Thr Lys Tyr 
    1160                 1165                 1170             


Val Thr  Ala Lys Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asn Arg 
    1175                 1180                 1185             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1190                 1195                 1200             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1205                 1210                 1215             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1220                 1225                 1230             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser Ile Pro  Asn Leu Pro 
    1235                 1240                 1245             


Asp Phe  Lys Glu Glu Leu Asp  Gln Trp Phe Lys Asn  Gln Thr Ser 
    1250                 1255                 1260             


Val Ala  Pro Asp Leu Ser Leu  Asp Tyr Ile Asn Val  Thr Phe Leu 
    1265                 1270                 1275             


Asp Leu  Gln Val Glu Met Asn  Arg Leu Gln Glu Ala  Ile Lys Val 
    1280                 1285                 1290             


Leu Asn  His Ser Tyr Ile Asn  Leu Lys Asp Ile Gly  Thr Tyr Glu 
    1295                 1300                 1305             


Tyr Tyr  Val Lys Trp Pro Trp  Tyr Val Trp Leu Leu  Ile Cys Leu 
    1310                 1315                 1320             


Ala Gly  Val Ala Met Leu Val  Leu Leu Phe Phe Ile  Cys Cys Cys 
    1325                 1330                 1335             


Thr Gly  Cys Gly Thr Ser Cys  Phe Lys Lys Cys Gly  Gly Cys Cys 
    1340                 1345                 1350             


Asp Asp  Tyr Thr Gly Tyr Gln  Glu Leu Val Ile Lys  Thr Ser His 
    1355                 1360                 1365             


Asp Asp  
    1370 


<210>  143
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-OC43-H5iTMCT-AA

<400>  143

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Ile Gly Asp Leu Asn Cys Thr 
            20                  25                  30          


Leu Asp Pro Arg Leu Lys Gly Ser Phe Asn Asn Arg Asp Thr Gly Pro 
        35                  40                  45              


Pro Ser Ile Ser Ile Asp Thr Val Asp Val Thr Asn Gly Leu Gly Thr 
    50                  55                  60                  


Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr Leu Phe Leu Asn 
65                  70                  75                  80  


Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn Met Ala Leu Lys 
                85                  90                  95      


Gly Thr Asp Leu Leu Ser Thr Leu Trp Phe Lys Pro Pro Phe Leu Ser 
            100                 105                 110         


Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn Thr Lys Val Phe 
        115                 120                 125             


Lys Asp Gly Val Met Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly Ser 
    130                 135                 140                 


Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln Pro Arg Thr Ile 
145                 150                 155                 160 


Asn Ser Thr Gln Asp Gly Val Asn Lys Leu Gln Gly Leu Leu Glu Val 
                165                 170                 175     


Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro His Thr Ile Cys His 
            180                 185                 190         


Pro Asn Leu Gly Asn His Phe Lys Glu Leu Trp His Tyr Asp Thr Gly 
        195                 200                 205             


Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr Asp Val Asn Ala 
    210                 215                 220                 


Thr Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr Ala 
225                 230                 235                 240 


Tyr Phe Thr Asp Thr Gly Phe Val Thr Lys Phe Leu Phe Asn Val Tyr 
                245                 250                 255     


Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro Leu Thr Cys Ile 
            260                 265                 270         


Arg Arg Pro Lys Asp Gly Phe Ser Leu Glu Tyr Trp Val Thr Pro Leu 
        275                 280                 285             


Thr Pro Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
    290                 295                 300                 


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
305                 310                 315                 320 


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
                325                 330                 335     


Thr Val Gln Pro Val Ala Asp Val Tyr Arg Arg Lys Pro Asp Leu Pro 
            340                 345                 350         


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
        355                 360                 365             


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
    370                 375                 380                 


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
385                 390                 395                 400 


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
                405                 410                 415     


Lys Phe Ala Ile Pro Asn Arg Arg Lys Val Asp Leu Gln Leu Gly Asn 
            420                 425                 430         


Leu Gly Tyr Leu Gln Ser Ser Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
        435                 440                 445             


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
    450                 455                 460                 


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
465                 470                 475                 480 


Ser Val Phe Val Pro Gln Pro Thr Gly Val Phe Thr Asn His Ser Val 
                485                 490                 495     


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
            500                 505                 510         


Ser Ser Cys Ser Cys Pro Gly Lys Asn Asn Gly Ile Gly Thr Cys Pro 
        515                 520                 525             


Ala Gly Thr Asn Ser Leu Thr Cys Asp Asn Leu Cys Thr Leu Asp Pro 
    530                 535                 540                 


Ile Thr Leu Lys Ala Pro Asp Thr Tyr Lys Cys Pro Gln Ser Lys Ser 
545                 550                 555                 560 


Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val Lys Ser Asp 
                565                 570                 575     


Tyr Cys Gly Asn Asn Ser Cys Thr Cys Gln Pro Gln Ala Phe Leu Gly 
            580                 585                 590         


Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn Ile Phe Ala 
        595                 600                 605             


Asn Phe Ile Leu His Asp Val Asn Asn Gly Leu Thr Cys Ser Thr Asp 
    610                 615                 620                 


Leu Gln Lys Ala Asn Thr Glu Ile Glu Leu Gly Val Cys Val Asn Tyr 
625                 630                 635                 640 


Asp Leu Tyr Gly Ile Ser Gly Gln Gly Ile Phe Val Glu Val Asn Ala 
                645                 650                 655     


Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn 
            660                 665                 670         


Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe Met Ile His 
        675                 680                 685             


Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Tyr His Ala Asn Ser Ser 
    690                 695                 700                 


Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr Val Phe Asn 
705                 710                 715                 720 


Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Ser Phe Asp Ser 
                725                 730                 735     


Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile Ser Val 
            740                 745                 750         


Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp Tyr Ser 
        755                 760                 765             


Lys Asn Gly Gly Ser Gly Ser Ala Ile Thr Thr Gly Tyr Arg Phe Thr 
    770                 775                 780                 


Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu Glu Pro 
785                 790                 795                 800 


Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr Ile Gly 
                805                 810                 815     


Asn Met Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
            820                 825                 830         


Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Leu Gln Leu 
        835                 840                 845             


Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu Thr Glu 
    850                 855                 860                 


Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn Ser Leu 
865                 870                 875                 880 


Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val Asn Phe 
                885                 890                 895     


Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu Gly Ser 
            900                 905                 910         


Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu Leu Phe 
        915                 920                 925             


Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn 
    930                 935                 940                 


Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln Ser Tyr 
945                 950                 955                 960 


Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln Ile Ser 
                965                 970                 975     


Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro Trp Thr 
            980                 985                 990         


Ala Ala Ala Gly Val Pro Phe Tyr  Leu Asn Val Gln Tyr  Arg Ile Asn 
        995                 1000                 1005             


Gly Leu  Gly Val Thr Met Asp  Val Leu Ser Gln Asn  Gln Lys Leu 
    1010                 1015                 1020             


Ile Ala  Asn Ala Phe Asn Asn  Ala Leu His Ala Ile  Gln Gln Gly 
    1025                 1030                 1035             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1040                 1045                 1050             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1055                 1060                 1065             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1070                 1075                 1080             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1085                 1090                 1095             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1100                 1105                 1110             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1115                 1120                 1125             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1130                 1135                 1140             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1145                 1150                 1155             


Tyr Gly  Leu Tyr Phe Ile His  Phe Asn Tyr Val Pro  Thr Lys Tyr 
    1160                 1165                 1170             


Val Thr  Ala Lys Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asn Arg 
    1175                 1180                 1185             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1190                 1195                 1200             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1205                 1210                 1215             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1220                 1225                 1230             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser Ile Pro  Asn Leu Pro 
    1235                 1240                 1245             


Asp Phe  Lys Glu Glu Leu Asp  Gln Trp Phe Lys Asn  Gln Thr Ser 
    1250                 1255                 1260             


Val Ala  Pro Asp Leu Ser Leu  Asp Tyr Ile Asn Val  Thr Phe Leu 
    1265                 1270                 1275             


Asp Leu  Gln Val Glu Met Asn  Arg Leu Gln Glu Ala  Ile Lys Val 
    1280                 1285                 1290             


Leu Asn  His Ser Tyr Ile Asn  Leu Lys Asp Ile Gly  Thr Tyr Glu 
    1295                 1300                 1305             


Tyr Tyr  Val Lys Trp Pro Trp  Tyr Gln Ile Leu Ser  Ile Tyr Ser 
    1310                 1315                 1320             


Thr Val  Ala Ser Ser Leu Ala  Leu Ala Ile Met Met  Ala Gly Leu 
    1325                 1330                 1335             


Ser Leu  Trp Met Cys Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys 
    1340                 1345                 1350             


Ile 
    


<210>  144
<211>  1351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-OC43-H5iCT-AA

<400>  144

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Ile Gly Asp Leu Asn Cys Thr 
            20                  25                  30          


Leu Asp Pro Arg Leu Lys Gly Ser Phe Asn Asn Arg Asp Thr Gly Pro 
        35                  40                  45              


Pro Ser Ile Ser Ile Asp Thr Val Asp Val Thr Asn Gly Leu Gly Thr 
    50                  55                  60                  


Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr Leu Phe Leu Asn 
65                  70                  75                  80  


Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn Met Ala Leu Lys 
                85                  90                  95      


Gly Thr Asp Leu Leu Ser Thr Leu Trp Phe Lys Pro Pro Phe Leu Ser 
            100                 105                 110         


Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn Thr Lys Val Phe 
        115                 120                 125             


Lys Asp Gly Val Met Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly Ser 
    130                 135                 140                 


Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln Pro Arg Thr Ile 
145                 150                 155                 160 


Asn Ser Thr Gln Asp Gly Val Asn Lys Leu Gln Gly Leu Leu Glu Val 
                165                 170                 175     


Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro His Thr Ile Cys His 
            180                 185                 190         


Pro Asn Leu Gly Asn His Phe Lys Glu Leu Trp His Tyr Asp Thr Gly 
        195                 200                 205             


Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr Asp Val Asn Ala 
    210                 215                 220                 


Thr Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr Ala 
225                 230                 235                 240 


Tyr Phe Thr Asp Thr Gly Phe Val Thr Lys Phe Leu Phe Asn Val Tyr 
                245                 250                 255     


Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro Leu Thr Cys Ile 
            260                 265                 270         


Arg Arg Pro Lys Asp Gly Phe Ser Leu Glu Tyr Trp Val Thr Pro Leu 
        275                 280                 285             


Thr Pro Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
    290                 295                 300                 


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
305                 310                 315                 320 


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
                325                 330                 335     


Thr Val Gln Pro Val Ala Asp Val Tyr Arg Arg Lys Pro Asp Leu Pro 
            340                 345                 350         


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
        355                 360                 365             


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
    370                 375                 380                 


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
385                 390                 395                 400 


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
                405                 410                 415     


Lys Phe Ala Ile Pro Asn Arg Arg Lys Val Asp Leu Gln Leu Gly Asn 
            420                 425                 430         


Leu Gly Tyr Leu Gln Ser Ser Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
        435                 440                 445             


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
    450                 455                 460                 


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
465                 470                 475                 480 


Ser Val Phe Val Pro Gln Pro Thr Gly Val Phe Thr Asn His Ser Val 
                485                 490                 495     


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
            500                 505                 510         


Ser Ser Cys Ser Cys Pro Gly Lys Asn Asn Gly Ile Gly Thr Cys Pro 
        515                 520                 525             


Ala Gly Thr Asn Ser Leu Thr Cys Asp Asn Leu Cys Thr Leu Asp Pro 
    530                 535                 540                 


Ile Thr Leu Lys Ala Pro Asp Thr Tyr Lys Cys Pro Gln Ser Lys Ser 
545                 550                 555                 560 


Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val Lys Ser Asp 
                565                 570                 575     


Tyr Cys Gly Asn Asn Ser Cys Thr Cys Gln Pro Gln Ala Phe Leu Gly 
            580                 585                 590         


Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn Ile Phe Ala 
        595                 600                 605             


Asn Phe Ile Leu His Asp Val Asn Asn Gly Leu Thr Cys Ser Thr Asp 
    610                 615                 620                 


Leu Gln Lys Ala Asn Thr Glu Ile Glu Leu Gly Val Cys Val Asn Tyr 
625                 630                 635                 640 


Asp Leu Tyr Gly Ile Ser Gly Gln Gly Ile Phe Val Glu Val Asn Ala 
                645                 650                 655     


Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn 
            660                 665                 670         


Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe Met Ile His 
        675                 680                 685             


Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Tyr His Ala Asn Ser Ser 
    690                 695                 700                 


Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr Val Phe Asn 
705                 710                 715                 720 


Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Ser Phe Asp Ser 
                725                 730                 735     


Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile Ser Val 
            740                 745                 750         


Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp Tyr Ser 
        755                 760                 765             


Lys Asn Gly Gly Ser Gly Ser Ala Ile Thr Thr Gly Tyr Arg Phe Thr 
    770                 775                 780                 


Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu Glu Pro 
785                 790                 795                 800 


Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr Ile Gly 
                805                 810                 815     


Asn Met Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
            820                 825                 830         


Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Leu Gln Leu 
        835                 840                 845             


Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu Thr Glu 
    850                 855                 860                 


Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn Ser Leu 
865                 870                 875                 880 


Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val Asn Phe 
                885                 890                 895     


Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu Gly Ser 
            900                 905                 910         


Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu Leu Phe 
        915                 920                 925             


Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn 
    930                 935                 940                 


Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln Ser Tyr 
945                 950                 955                 960 


Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln Ile Ser 
                965                 970                 975     


Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro Trp Thr 
            980                 985                 990         


Ala Ala Ala Gly Val Pro Phe Tyr  Leu Asn Val Gln Tyr  Arg Ile Asn 
        995                 1000                 1005             


Gly Leu  Gly Val Thr Met Asp  Val Leu Ser Gln Asn  Gln Lys Leu 
    1010                 1015                 1020             


Ile Ala  Asn Ala Phe Asn Asn  Ala Leu His Ala Ile  Gln Gln Gly 
    1025                 1030                 1035             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1040                 1045                 1050             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1055                 1060                 1065             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1070                 1075                 1080             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1085                 1090                 1095             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1100                 1105                 1110             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1115                 1120                 1125             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1130                 1135                 1140             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1145                 1150                 1155             


Tyr Gly  Leu Tyr Phe Ile His  Phe Asn Tyr Val Pro  Thr Lys Tyr 
    1160                 1165                 1170             


Val Thr  Ala Lys Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asn Arg 
    1175                 1180                 1185             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1190                 1195                 1200             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1205                 1210                 1215             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1220                 1225                 1230             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser Ile Pro  Asn Leu Pro 
    1235                 1240                 1245             


Asp Phe  Lys Glu Glu Leu Asp  Gln Trp Phe Lys Asn  Gln Thr Ser 
    1250                 1255                 1260             


Val Ala  Pro Asp Leu Ser Leu  Asp Tyr Ile Asn Val  Thr Phe Leu 
    1265                 1270                 1275             


Asp Leu  Gln Val Glu Met Asn  Arg Leu Gln Glu Ala  Ile Lys Val 
    1280                 1285                 1290             


Leu Asn  His Ser Tyr Ile Asn  Leu Lys Asp Ile Gly  Thr Tyr Glu 
    1295                 1300                 1305             


Tyr Tyr  Val Lys Trp Pro Trp  Tyr Val Trp Leu Leu  Ile Cys Leu 
    1310                 1315                 1320             


Ala Gly  Val Ala Met Leu Val  Leu Leu Phe Phe Ile  Ser Leu Trp 
    1325                 1330                 1335             


Met Cys  Ser Asn Gly Ser Leu  Gln Cys Arg Ile Cys  Ile 
    1340                 1345                 1350     


<210>  145
<211>  1348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-OC43-H5iCT(V4)-AA

<400>  145

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Ile Gly Asp Leu Asn Cys Thr 
            20                  25                  30          


Leu Asp Pro Arg Leu Lys Gly Ser Phe Asn Asn Arg Asp Thr Gly Pro 
        35                  40                  45              


Pro Ser Ile Ser Ile Asp Thr Val Asp Val Thr Asn Gly Leu Gly Thr 
    50                  55                  60                  


Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr Leu Phe Leu Asn 
65                  70                  75                  80  


Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn Met Ala Leu Lys 
                85                  90                  95      


Gly Thr Asp Leu Leu Ser Thr Leu Trp Phe Lys Pro Pro Phe Leu Ser 
            100                 105                 110         


Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn Thr Lys Val Phe 
        115                 120                 125             


Lys Asp Gly Val Met Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly Ser 
    130                 135                 140                 


Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln Pro Arg Thr Ile 
145                 150                 155                 160 


Asn Ser Thr Gln Asp Gly Val Asn Lys Leu Gln Gly Leu Leu Glu Val 
                165                 170                 175     


Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro His Thr Ile Cys His 
            180                 185                 190         


Pro Asn Leu Gly Asn His Phe Lys Glu Leu Trp His Tyr Asp Thr Gly 
        195                 200                 205             


Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr Asp Val Asn Ala 
    210                 215                 220                 


Thr Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr Ala 
225                 230                 235                 240 


Tyr Phe Thr Asp Thr Gly Phe Val Thr Lys Phe Leu Phe Asn Val Tyr 
                245                 250                 255     


Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro Leu Thr Cys Ile 
            260                 265                 270         


Arg Arg Pro Lys Asp Gly Phe Ser Leu Glu Tyr Trp Val Thr Pro Leu 
        275                 280                 285             


Thr Pro Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
    290                 295                 300                 


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
305                 310                 315                 320 


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
                325                 330                 335     


Thr Val Gln Pro Val Ala Asp Val Tyr Arg Arg Lys Pro Asp Leu Pro 
            340                 345                 350         


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
        355                 360                 365             


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
    370                 375                 380                 


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
385                 390                 395                 400 


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
                405                 410                 415     


Lys Phe Ala Ile Pro Asn Arg Arg Lys Val Asp Leu Gln Leu Gly Asn 
            420                 425                 430         


Leu Gly Tyr Leu Gln Ser Ser Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
        435                 440                 445             


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
    450                 455                 460                 


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
465                 470                 475                 480 


Ser Val Phe Val Pro Gln Pro Thr Gly Val Phe Thr Asn His Ser Val 
                485                 490                 495     


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
            500                 505                 510         


Ser Ser Cys Ser Cys Pro Gly Lys Asn Asn Gly Ile Gly Thr Cys Pro 
        515                 520                 525             


Ala Gly Thr Asn Ser Leu Thr Cys Asp Asn Leu Cys Thr Leu Asp Pro 
    530                 535                 540                 


Ile Thr Leu Lys Ala Pro Asp Thr Tyr Lys Cys Pro Gln Ser Lys Ser 
545                 550                 555                 560 


Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val Lys Ser Asp 
                565                 570                 575     


Tyr Cys Gly Asn Asn Ser Cys Thr Cys Gln Pro Gln Ala Phe Leu Gly 
            580                 585                 590         


Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn Ile Phe Ala 
        595                 600                 605             


Asn Phe Ile Leu His Asp Val Asn Asn Gly Leu Thr Cys Ser Thr Asp 
    610                 615                 620                 


Leu Gln Lys Ala Asn Thr Glu Ile Glu Leu Gly Val Cys Val Asn Tyr 
625                 630                 635                 640 


Asp Leu Tyr Gly Ile Ser Gly Gln Gly Ile Phe Val Glu Val Asn Ala 
                645                 650                 655     


Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn 
            660                 665                 670         


Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe Met Ile His 
        675                 680                 685             


Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Tyr His Ala Asn Ser Ser 
    690                 695                 700                 


Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr Val Phe Asn 
705                 710                 715                 720 


Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Ser Phe Asp Ser 
                725                 730                 735     


Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile Ser Val 
            740                 745                 750         


Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp Tyr Ser 
        755                 760                 765             


Lys Asn Gly Gly Ser Gly Ser Ala Ile Thr Thr Gly Tyr Arg Phe Thr 
    770                 775                 780                 


Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu Glu Pro 
785                 790                 795                 800 


Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr Ile Gly 
                805                 810                 815     


Asn Met Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
            820                 825                 830         


Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Leu Gln Leu 
        835                 840                 845             


Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu Thr Glu 
    850                 855                 860                 


Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn Ser Leu 
865                 870                 875                 880 


Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val Asn Phe 
                885                 890                 895     


Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu Gly Ser 
            900                 905                 910         


Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu Leu Phe 
        915                 920                 925             


Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn 
    930                 935                 940                 


Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln Ser Tyr 
945                 950                 955                 960 


Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln Ile Ser 
                965                 970                 975     


Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro Trp Thr 
            980                 985                 990         


Ala Ala Ala Gly Val Pro Phe Tyr  Leu Asn Val Gln Tyr  Arg Ile Asn 
        995                 1000                 1005             


Gly Leu  Gly Val Thr Met Asp  Val Leu Ser Gln Asn  Gln Lys Leu 
    1010                 1015                 1020             


Ile Ala  Asn Ala Phe Asn Asn  Ala Leu His Ala Ile  Gln Gln Gly 
    1025                 1030                 1035             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1040                 1045                 1050             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1055                 1060                 1065             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1070                 1075                 1080             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1085                 1090                 1095             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1100                 1105                 1110             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1115                 1120                 1125             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1130                 1135                 1140             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1145                 1150                 1155             


Tyr Gly  Leu Tyr Phe Ile His  Phe Asn Tyr Val Pro  Thr Lys Tyr 
    1160                 1165                 1170             


Val Thr  Ala Lys Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asn Arg 
    1175                 1180                 1185             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1190                 1195                 1200             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1205                 1210                 1215             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1220                 1225                 1230             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser Ile Pro  Asn Leu Pro 
    1235                 1240                 1245             


Asp Phe  Lys Glu Glu Leu Asp  Gln Trp Phe Lys Asn  Gln Thr Ser 
    1250                 1255                 1260             


Val Ala  Pro Asp Leu Ser Leu  Asp Tyr Ile Asn Val  Thr Phe Leu 
    1265                 1270                 1275             


Asp Leu  Gln Val Glu Met Asn  Arg Leu Gln Glu Ala  Ile Lys Val 
    1280                 1285                 1290             


Leu Asn  His Ser Tyr Ile Asn  Leu Lys Asp Ile Gly  Thr Tyr Glu 
    1295                 1300                 1305             


Tyr Tyr  Val Lys Trp Pro Trp  Tyr Val Trp Leu Leu  Ile Cys Leu 
    1310                 1315                 1320             


Ala Gly  Val Ala Met Leu Val  Leu Leu Phe Phe Ile  Cys Cys Ser 
    1325                 1330                 1335             


Asn Gly  Ser Leu Gln Cys Arg  Ile Cys Ile 
    1340                 1345             


<210>  146
<211>  1351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-OC43-H1cCT-AA

<400>  146

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Val Ile Gly Asp Leu Asn Cys Thr 
            20                  25                  30          


Leu Asp Pro Arg Leu Lys Gly Ser Phe Asn Asn Arg Asp Thr Gly Pro 
        35                  40                  45              


Pro Ser Ile Ser Ile Asp Thr Val Asp Val Thr Asn Gly Leu Gly Thr 
    50                  55                  60                  


Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr Leu Phe Leu Asn 
65                  70                  75                  80  


Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn Met Ala Leu Lys 
                85                  90                  95      


Gly Thr Asp Leu Leu Ser Thr Leu Trp Phe Lys Pro Pro Phe Leu Ser 
            100                 105                 110         


Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn Thr Lys Val Phe 
        115                 120                 125             


Lys Asp Gly Val Met Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly Ser 
    130                 135                 140                 


Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln Pro Arg Thr Ile 
145                 150                 155                 160 


Asn Ser Thr Gln Asp Gly Val Asn Lys Leu Gln Gly Leu Leu Glu Val 
                165                 170                 175     


Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro His Thr Ile Cys His 
            180                 185                 190         


Pro Asn Leu Gly Asn His Phe Lys Glu Leu Trp His Tyr Asp Thr Gly 
        195                 200                 205             


Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr Asp Val Asn Ala 
    210                 215                 220                 


Thr Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr Ala 
225                 230                 235                 240 


Tyr Phe Thr Asp Thr Gly Phe Val Thr Lys Phe Leu Phe Asn Val Tyr 
                245                 250                 255     


Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro Leu Thr Cys Ile 
            260                 265                 270         


Arg Arg Pro Lys Asp Gly Phe Ser Leu Glu Tyr Trp Val Thr Pro Leu 
        275                 280                 285             


Thr Pro Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe 
    290                 295                 300                 


Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys 
305                 310                 315                 320 


Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr 
                325                 330                 335     


Thr Val Gln Pro Val Ala Asp Val Tyr Arg Arg Lys Pro Asp Leu Pro 
            340                 345                 350         


Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro 
        355                 360                 365             


Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser 
    370                 375                 380                 


Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile 
385                 390                 395                 400 


Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp 
                405                 410                 415     


Lys Phe Ala Ile Pro Asn Arg Arg Lys Val Asp Leu Gln Leu Gly Asn 
            420                 425                 430         


Leu Gly Tyr Leu Gln Ser Ser Asn Tyr Arg Ile Asp Thr Thr Ala Thr 
        435                 440                 445             


Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser 
    450                 455                 460                 


Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp 
465                 470                 475                 480 


Ser Val Phe Val Pro Gln Pro Thr Gly Val Phe Thr Asn His Ser Val 
                485                 490                 495     


Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys 
            500                 505                 510         


Ser Ser Cys Ser Cys Pro Gly Lys Asn Asn Gly Ile Gly Thr Cys Pro 
        515                 520                 525             


Ala Gly Thr Asn Ser Leu Thr Cys Asp Asn Leu Cys Thr Leu Asp Pro 
    530                 535                 540                 


Ile Thr Leu Lys Ala Pro Asp Thr Tyr Lys Cys Pro Gln Ser Lys Ser 
545                 550                 555                 560 


Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val Lys Ser Asp 
                565                 570                 575     


Tyr Cys Gly Asn Asn Ser Cys Thr Cys Gln Pro Gln Ala Phe Leu Gly 
            580                 585                 590         


Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn Ile Phe Ala 
        595                 600                 605             


Asn Phe Ile Leu His Asp Val Asn Asn Gly Leu Thr Cys Ser Thr Asp 
    610                 615                 620                 


Leu Gln Lys Ala Asn Thr Glu Ile Glu Leu Gly Val Cys Val Asn Tyr 
625                 630                 635                 640 


Asp Leu Tyr Gly Ile Ser Gly Gln Gly Ile Phe Val Glu Val Asn Ala 
                645                 650                 655     


Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn 
            660                 665                 670         


Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe Met Ile His 
        675                 680                 685             


Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Tyr His Ala Asn Ser Ser 
    690                 695                 700                 


Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr Val Phe Asn 
705                 710                 715                 720 


Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Ser Phe Asp Ser 
                725                 730                 735     


Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile Ser Val 
            740                 745                 750         


Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp Tyr Ser 
        755                 760                 765             


Lys Asn Gly Gly Ser Gly Ser Ala Ile Thr Thr Gly Tyr Arg Phe Thr 
    770                 775                 780                 


Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu Glu Pro 
785                 790                 795                 800 


Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr Ile Gly 
                805                 810                 815     


Asn Met Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp 
            820                 825                 830         


Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Leu Gln Leu 
        835                 840                 845             


Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu Thr Glu 
    850                 855                 860                 


Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn Ser Leu 
865                 870                 875                 880 


Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val Asn Phe 
                885                 890                 895     


Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu Gly Ser 
            900                 905                 910         


Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu Leu Phe 
        915                 920                 925             


Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn 
    930                 935                 940                 


Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln Ser Tyr 
945                 950                 955                 960 


Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln Ile Ser 
                965                 970                 975     


Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro Trp Thr 
            980                 985                 990         


Ala Ala Ala Gly Val Pro Phe Tyr  Leu Asn Val Gln Tyr  Arg Ile Asn 
        995                 1000                 1005             


Gly Leu  Gly Val Thr Met Asp  Val Leu Ser Gln Asn  Gln Lys Leu 
    1010                 1015                 1020             


Ile Ala  Asn Ala Phe Asn Asn  Ala Leu His Ala Ile  Gln Gln Gly 
    1025                 1030                 1035             


Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys Ile Gln  Ala Val Val 
    1040                 1045                 1050             


Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser 
    1055                 1060                 1065             


Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser 
    1070                 1075                 1080             


Arg Leu  Asp Pro Pro Glu Ala  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1085                 1090                 1095             


Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr Val Ser  Gln Gln Leu 
    1100                 1105                 1110             


Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala Ala Gln  Ala Met Glu 
    1115                 1120                 1125             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Ser Arg  Ile Asn Phe 
    1130                 1135                 1140             


Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu Val Gln  Asn Ala Pro 
    1145                 1150                 1155             


Tyr Gly  Leu Tyr Phe Ile His  Phe Asn Tyr Val Pro  Thr Lys Tyr 
    1160                 1165                 1170             


Val Thr  Ala Lys Val Ser Pro  Gly Leu Cys Ile Ala  Gly Asn Arg 
    1175                 1180                 1185             


Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val Asn Val  Asn Asn Thr 
    1190                 1195                 1200             


Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Thr 
    1205                 1210                 1215             


Glu Asn  Asn Val Val Val Met  Ser Thr Cys Ala Val  Asn Tyr Thr 
    1220                 1225                 1230             


Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser Ile Pro  Asn Leu Pro 
    1235                 1240                 1245             


Asp Phe  Lys Glu Glu Leu Asp  Gln Trp Phe Lys Asn  Gln Thr Ser 
    1250                 1255                 1260             


Val Ala  Pro Asp Leu Ser Leu  Asp Tyr Ile Asn Val  Thr Phe Leu 
    1265                 1270                 1275             


Asp Leu  Gln Val Glu Met Asn  Arg Leu Gln Glu Ala  Ile Lys Val 
    1280                 1285                 1290             


Leu Asn  His Ser Tyr Ile Asn  Leu Lys Asp Ile Gly  Thr Tyr Glu 
    1295                 1300                 1305             


Tyr Tyr  Val Lys Trp Pro Trp  Tyr Val Trp Leu Leu  Ile Cys Leu 
    1310                 1315                 1320             


Ala Gly  Val Ala Met Leu Val  Leu Leu Phe Phe Ile  Ser Phe Trp 
    1325                 1330                 1335             


Met Cys  Ser Asn Gly Ser Leu  Gln Cys Arg Ile Cys  Ile 
    1340                 1345                 1350     


<210>  147
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(CoV229EwtCT).r

<400>  147
acgacacgac taaggccttc actgtatgtg gatcttttcg acatcgta                    48


<210>  148
<211>  3546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-229E -wtTMCT-DNA

<400>  148
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaacgac taatgggctg aacaccagtt acagcgtctg taacggctgc      120

gtcggatata gcgagaacgt gttcgcagtg gaaagtgggg ggtacattcc ttccgacttc      180

gctttcaata actggtttct cctgactaac acaagctccg tcgtggatgg cgtggtcagg      240

tcctttcagc ctcttctcct gaattgcctg tggtctgtgt ccgggttaag attcactaca      300

ggcttcgtat acttcaacgg gacgggccgg ggggattgca agggcttctc ctccgacgtg      360

ctgtcagatg tgatccgtta caatctgaac ttcgaagaga acttacggcg ggggacaatc      420

ctgttcaaaa catcatatgg cgtagtcgta ttttactgca ccaataatac cctggtgagt      480

ggggacgccc atattccctt cggaacagtg ctgggtaact tttactgttt tgtcaacact      540

acgatcggaa acgaaaccac tagcgccttt gtcggagctc tgccaaaaac agttagggag      600

ttcgtgatct ctcggaccgg tcacttctat atcaacggct accgttattt tactttgggc      660

aacgtcgaag ccgtcaattt taatgtgaca actgcagaga caactgactt ttgcactgtg      720

gctctcgcca gttatgccga tgtgctggtg aatgtaagtc aaacgtcaat tgccaacatc      780

atctattgta actcagtaat caaccggctc cgctgtgacc aactctcatt cgacgtcccc      840

gacggattct attccacgag cccgattcag agcgtggaac tgccagtttc catcgtatcc      900

ctcccagttt accacaagca cacttttatc gttctctacg tagattttaa accccagtca      960

ggaggaggga aatgcttcaa ctgctacccg gctggcgtga acatcacctt ggccaatttt     1020

aatgaaacta aagggcccct ttgcgtggat acgtcacact ttaccacaaa gtatgttgca     1080

gtctatgcta acgtcggcag gtggtcagcg tccattaaca caggcaattg cccgttctct     1140

ttcgggaaag tgaacaactt cgtgaagttt ggaagtgtgt gcttcagttt gaaagacatt     1200

ccgggcggct gcgccatgcc tattgtggct aattgggctt attccaagta ctacaccatt     1260

ggctctctct acgttagctg gagcgacggt gacggtataa cgggcgtacc acaaccggtg     1320

gaaggggtca gctctttcat gaatgtcact ctggacaagt gtaccaaata taatatatac     1380

gatgtgagtg gagtgggcgt tatacgcgtg tctaacgaca cctttctaaa cggcataacc     1440

tacacaagca cgtcaggcaa tctgttaggt tttaaagacg tcactaaagg cactatatat     1500

agcatcaccc catgcaaccc acctgatcaa ttagtcgtat atcagcaagc tgttgtgggt     1560

gctatgctgt cagaaaactt caccagctac gggttctcca atgtggtgga actgcccaaa     1620

ttcttttacg ctagcaatgg cacatataac tgtactgacg ccgtcttgac ttacagttca     1680

ttcggagtgt gcgcggacgg cagcattatc gccgtgcagc cggccaatgt cagctatgat     1740

tccgtttccg ccatcgtgac agccaacttg tcgattccct ctaactggac aacgtctgtc     1800

caagtcgaat atctgcagat cacctcaacc cccatagtag tcgattgctc aacctacgtc     1860

tgcaacggta atgtcagatg tgtcgagctg ctcaagcagt acacctccgc ctgtaagact     1920

attgaggatg cattaagaaa tagtgcaaga ttggaaagcg ccgatgtgtc ggaaatgcta     1980

accttcgata agaaggcatt cacactggcg aacgtaagct ctttcggcga ttacaacctg     2040

tcttcggtaa tccctagctt gcccacatcc ggctctcggg tggcggggcg gagcgctatc     2100

gaggacattt tattctcgaa actggttaca tctgggctcg gaactgtgga cgccgattac     2160

aagaagtgca ccaagggcct aagcatcgcc gacctcgcct gtgctcagta ctacaacgga     2220

attatggtgc tgccaggtgt cgctgacgca gagcggatgg ctatgtatac cggcagtctc     2280

attggcggga ttgcgttggg cggcctgacg tccgctgtct ccatcccttt ctctctggct     2340

atacaagccc gactgaatta tgtggccctg cagactgatg tcctgcaaga aaatcagaag     2400

attcttgccg ccagcttcaa caaggccatg actaatattg tggatgcgtt taccggagtg     2460

aatgacgcca tcacccaaac gtcccaagcc ctgcagacag tcgccacggc gttaaacaaa     2520

atccaggatg tagtgaatca gcaagggaac agcttgaatc acctgacgtc ccagttaaga     2580

cagaactttc aggcaatcag tagctcaatc caggctatct acgatcgatt agatcctcct     2640

caggcagatc agcaggtgga tcggctcatc accggccgcc tcgcggcatt gaatgttttc     2700

gtaagtcata ccttgaccaa gtacacggag gtgagggcca gtcgccagct ggctcagcaa     2760

aaagtgaatg agtgtgtgaa atcacagagc aaacggtacg ggttttgtgg aaatgggacg     2820

cacatcttta gcatcgttaa tgctgccccc gaagggttag tcttcctgca cactgtgctc     2880

cttcctaccc agtataaaga tgtcgaagca tggtctgggc tctgtgtcga tggaactaac     2940

ggttatgtcc ttcgacagcc aaacctcgct ctctataaag aagggaatta ctataggatc     3000

acctcaagaa tcatgttcga gcccaggata ccaacaatgg ccgattttgt gcagattgaa     3060

aattgtaacg tgacctttgt gaatatcagt cgatccgagc ttcaaacgat tgttcctgag     3120

tacatcgacg tgaataaaac tctacaagag ctgtcctata aactgcctaa ttataccgtg     3180

cctgaccttg tagtcgagca atacaaccag actattctga acctgacatc ggaaatctct     3240

acattggaga ataaaagcgc cgagctcaat tacacagtgc agaagctgca gaccctgatc     3300

gacaatatta acagcactct tgtggactta aagtggctga accgtgtgga gacttacatc     3360

aagtggccct ggtgggtgtg gctctgtatt tccgtggtcc ttatatttgt tgtaagtatg     3420

ctgctcctgt gctgttgctc aaccgggtgc tgcggttttt tctcctgttt cgcctcatcc     3480

atccgtggct gttgtgagag cactaaactg ccatattacg atgtcgaaaa gatccacata     3540

cagtga                                                                3546


<210>  149
<211>  3492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-229E -H5iTMCT-DNA

<400>  149
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaacgac taatgggctg aacaccagtt acagcgtctg taacggctgc      120

gtcggatata gcgagaacgt gttcgcagtg gaaagtgggg ggtacattcc ttccgacttc      180

gctttcaata actggtttct cctgactaac acaagctccg tcgtggatgg cgtggtcagg      240

tcctttcagc ctcttctcct gaattgcctg tggtctgtgt ccgggttaag attcactaca      300

ggcttcgtat acttcaacgg gacgggccgg ggggattgca agggcttctc ctccgacgtg      360

ctgtcagatg tgatccgtta caatctgaac ttcgaagaga acttacggcg ggggacaatc      420

ctgttcaaaa catcatatgg cgtagtcgta ttttactgca ccaataatac cctggtgagt      480

ggggacgccc atattccctt cggaacagtg ctgggtaact tttactgttt tgtcaacact      540

acgatcggaa acgaaaccac tagcgccttt gtcggagctc tgccaaaaac agttagggag      600

ttcgtgatct ctcggaccgg tcacttctat atcaacggct accgttattt tactttgggc      660

aacgtcgaag ccgtcaattt taatgtgaca actgcagaga caactgactt ttgcactgtg      720

gctctcgcca gttatgccga tgtgctggtg aatgtaagtc aaacgtcaat tgccaacatc      780

atctattgta actcagtaat caaccggctc cgctgtgacc aactctcatt cgacgtcccc      840

gacggattct attccacgag cccgattcag agcgtggaac tgccagtttc catcgtatcc      900

ctcccagttt accacaagca cacttttatc gttctctacg tagattttaa accccagtca      960

ggaggaggga aatgcttcaa ctgctacccg gctggcgtga acatcacctt ggccaatttt     1020

aatgaaacta aagggcccct ttgcgtggat acgtcacact ttaccacaaa gtatgttgca     1080

gtctatgcta acgtcggcag gtggtcagcg tccattaaca caggcaattg cccgttctct     1140

ttcgggaaag tgaacaactt cgtgaagttt ggaagtgtgt gcttcagttt gaaagacatt     1200

ccgggcggct gcgccatgcc tattgtggct aattgggctt attccaagta ctacaccatt     1260

ggctctctct acgttagctg gagcgacggt gacggtataa cgggcgtacc acaaccggtg     1320

gaaggggtca gctctttcat gaatgtcact ctggacaagt gtaccaaata taatatatac     1380

gatgtgagtg gagtgggcgt tatacgcgtg tctaacgaca cctttctaaa cggcataacc     1440

tacacaagca cgtcaggcaa tctgttaggt tttaaagacg tcactaaagg cactatatat     1500

agcatcaccc catgcaaccc acctgatcaa ttagtcgtat atcagcaagc tgttgtgggt     1560

gctatgctgt cagaaaactt caccagctac gggttctcca atgtggtgga actgcccaaa     1620

ttcttttacg ctagcaatgg cacatataac tgtactgacg ccgtcttgac ttacagttca     1680

ttcggagtgt gcgcggacgg cagcattatc gccgtgcagc cggccaatgt cagctatgat     1740

tccgtttccg ccatcgtgac agccaacttg tcgattccct ctaactggac aacgtctgtc     1800

caagtcgaat atctgcagat cacctcaacc cccatagtag tcgattgctc aacctacgtc     1860

tgcaacggta atgtcagatg tgtcgagctg ctcaagcagt acacctccgc ctgtaagact     1920

attgaggatg cattaagaaa tagtgcaaga ttggaaagcg ccgatgtgtc ggaaatgcta     1980

accttcgata agaaggcatt cacactggcg aacgtaagct ctttcggcga ttacaacctg     2040

tcttcggtaa tccctagctt gcccacatcc ggctctcggg tggcggggcg gagcgctatc     2100

gaggacattt tattctcgaa actggttaca tctgggctcg gaactgtgga cgccgattac     2160

aagaagtgca ccaagggcct aagcatcgcc gacctcgcct gtgctcagta ctacaacgga     2220

attatggtgc tgccaggtgt cgctgacgca gagcggatgg ctatgtatac cggcagtctc     2280

attggcggga ttgcgttggg cggcctgacg tccgctgtct ccatcccttt ctctctggct     2340

atacaagccc gactgaatta tgtggccctg cagactgatg tcctgcaaga aaatcagaag     2400

attcttgccg ccagcttcaa caaggccatg actaatattg tggatgcgtt taccggagtg     2460

aatgacgcca tcacccaaac gtcccaagcc ctgcagacag tcgccacggc gttaaacaaa     2520

atccaggatg tagtgaatca gcaagggaac agcttgaatc acctgacgtc ccagttaaga     2580

cagaactttc aggcaatcag tagctcaatc caggctatct acgatcgatt agatcctcct     2640

caggcagatc agcaggtgga tcggctcatc accggccgcc tcgcggcatt gaatgttttc     2700

gtaagtcata ccttgaccaa gtacacggag gtgagggcca gtcgccagct ggctcagcaa     2760

aaagtgaatg agtgtgtgaa atcacagagc aaacggtacg ggttttgtgg aaatgggacg     2820

cacatcttta gcatcgttaa tgctgccccc gaagggttag tcttcctgca cactgtgctc     2880

cttcctaccc agtataaaga tgtcgaagca tggtctgggc tctgtgtcga tggaactaac     2940

ggttatgtcc ttcgacagcc aaacctcgct ctctataaag aagggaatta ctataggatc     3000

acctcaagaa tcatgttcga gcccaggata ccaacaatgg ccgattttgt gcagattgaa     3060

aattgtaacg tgacctttgt gaatatcagt cgatccgagc ttcaaacgat tgttcctgag     3120

tacatcgacg tgaataaaac tctacaagag ctgtcctata aactgcctaa ttataccgtg     3180

cctgaccttg tagtcgagca atacaaccag actattctga acctgacatc ggaaatctct     3240

acattggaga ataaaagcgc cgagctcaat tacacagtgc agaagctgca gaccctgatc     3300

gacaatatta acagcactct tgtggactta aagtggctga accgtgtgga gacttacatc     3360

aagtggccct ggtggcaaat actgtcaatt tattcaacag tggcgagttc cctagcactg     3420

gcaatcatga tggctggtct atctttatgg atgtgctcca atggatcgtt acaatgcaga     3480

atttgcattt ga                                                         3492


<210>  150
<211>  3480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-229E -H5iCT-DNA

<400>  150
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaacgac taatgggctg aacaccagtt acagcgtctg taacggctgc      120

gtcggatata gcgagaacgt gttcgcagtg gaaagtgggg ggtacattcc ttccgacttc      180

gctttcaata actggtttct cctgactaac acaagctccg tcgtggatgg cgtggtcagg      240

tcctttcagc ctcttctcct gaattgcctg tggtctgtgt ccgggttaag attcactaca      300

ggcttcgtat acttcaacgg gacgggccgg ggggattgca agggcttctc ctccgacgtg      360

ctgtcagatg tgatccgtta caatctgaac ttcgaagaga acttacggcg ggggacaatc      420

ctgttcaaaa catcatatgg cgtagtcgta ttttactgca ccaataatac cctggtgagt      480

ggggacgccc atattccctt cggaacagtg ctgggtaact tttactgttt tgtcaacact      540

acgatcggaa acgaaaccac tagcgccttt gtcggagctc tgccaaaaac agttagggag      600

ttcgtgatct ctcggaccgg tcacttctat atcaacggct accgttattt tactttgggc      660

aacgtcgaag ccgtcaattt taatgtgaca actgcagaga caactgactt ttgcactgtg      720

gctctcgcca gttatgccga tgtgctggtg aatgtaagtc aaacgtcaat tgccaacatc      780

atctattgta actcagtaat caaccggctc cgctgtgacc aactctcatt cgacgtcccc      840

gacggattct attccacgag cccgattcag agcgtggaac tgccagtttc catcgtatcc      900

ctcccagttt accacaagca cacttttatc gttctctacg tagattttaa accccagtca      960

ggaggaggga aatgcttcaa ctgctacccg gctggcgtga acatcacctt ggccaatttt     1020

aatgaaacta aagggcccct ttgcgtggat acgtcacact ttaccacaaa gtatgttgca     1080

gtctatgcta acgtcggcag gtggtcagcg tccattaaca caggcaattg cccgttctct     1140

ttcgggaaag tgaacaactt cgtgaagttt ggaagtgtgt gcttcagttt gaaagacatt     1200

ccgggcggct gcgccatgcc tattgtggct aattgggctt attccaagta ctacaccatt     1260

ggctctctct acgttagctg gagcgacggt gacggtataa cgggcgtacc acaaccggtg     1320

gaaggggtca gctctttcat gaatgtcact ctggacaagt gtaccaaata taatatatac     1380

gatgtgagtg gagtgggcgt tatacgcgtg tctaacgaca cctttctaaa cggcataacc     1440

tacacaagca cgtcaggcaa tctgttaggt tttaaagacg tcactaaagg cactatatat     1500

agcatcaccc catgcaaccc acctgatcaa ttagtcgtat atcagcaagc tgttgtgggt     1560

gctatgctgt cagaaaactt caccagctac gggttctcca atgtggtgga actgcccaaa     1620

ttcttttacg ctagcaatgg cacatataac tgtactgacg ccgtcttgac ttacagttca     1680

ttcggagtgt gcgcggacgg cagcattatc gccgtgcagc cggccaatgt cagctatgat     1740

tccgtttccg ccatcgtgac agccaacttg tcgattccct ctaactggac aacgtctgtc     1800

caagtcgaat atctgcagat cacctcaacc cccatagtag tcgattgctc aacctacgtc     1860

tgcaacggta atgtcagatg tgtcgagctg ctcaagcagt acacctccgc ctgtaagact     1920

attgaggatg cattaagaaa tagtgcaaga ttggaaagcg ccgatgtgtc ggaaatgcta     1980

accttcgata agaaggcatt cacactggcg aacgtaagct ctttcggcga ttacaacctg     2040

tcttcggtaa tccctagctt gcccacatcc ggctctcggg tggcggggcg gagcgctatc     2100

gaggacattt tattctcgaa actggttaca tctgggctcg gaactgtgga cgccgattac     2160

aagaagtgca ccaagggcct aagcatcgcc gacctcgcct gtgctcagta ctacaacgga     2220

attatggtgc tgccaggtgt cgctgacgca gagcggatgg ctatgtatac cggcagtctc     2280

attggcggga ttgcgttggg cggcctgacg tccgctgtct ccatcccttt ctctctggct     2340

atacaagccc gactgaatta tgtggccctg cagactgatg tcctgcaaga aaatcagaag     2400

attcttgccg ccagcttcaa caaggccatg actaatattg tggatgcgtt taccggagtg     2460

aatgacgcca tcacccaaac gtcccaagcc ctgcagacag tcgccacggc gttaaacaaa     2520

atccaggatg tagtgaatca gcaagggaac agcttgaatc acctgacgtc ccagttaaga     2580

cagaactttc aggcaatcag tagctcaatc caggctatct acgatcgatt agatcctcct     2640

caggcagatc agcaggtgga tcggctcatc accggccgcc tcgcggcatt gaatgttttc     2700

gtaagtcata ccttgaccaa gtacacggag gtgagggcca gtcgccagct ggctcagcaa     2760

aaagtgaatg agtgtgtgaa atcacagagc aaacggtacg ggttttgtgg aaatgggacg     2820

cacatcttta gcatcgttaa tgctgccccc gaagggttag tcttcctgca cactgtgctc     2880

cttcctaccc agtataaaga tgtcgaagca tggtctgggc tctgtgtcga tggaactaac     2940

ggttatgtcc ttcgacagcc aaacctcgct ctctataaag aagggaatta ctataggatc     3000

acctcaagaa tcatgttcga gcccaggata ccaacaatgg ccgattttgt gcagattgaa     3060

aattgtaacg tgacctttgt gaatatcagt cgatccgagc ttcaaacgat tgttcctgag     3120

tacatcgacg tgaataaaac tctacaagag ctgtcctata aactgcctaa ttataccgtg     3180

cctgaccttg tagtcgagca atacaaccag actattctga acctgacatc ggaaatctct     3240

acattggaga ataaaagcgc cgagctcaat tacacagtgc agaagctgca gaccctgatc     3300

gacaatatta acagcactct tgtggactta aagtggctga accgtgtgga gacttacatc     3360

aagtggccct ggtgggtgtg gctctgtatt tccgtggtcc ttatatttgt tgtaagtatg     3420

ctgctcctgt ctttatggat gtgctccaat ggatcgttac aatgcagaat ttgcatttga     3480


<210>  151
<211>  3471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-229E -H5iCT(V4)-DNA

<400>  151
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaacgac taatgggctg aacaccagtt acagcgtctg taacggctgc      120

gtcggatata gcgagaacgt gttcgcagtg gaaagtgggg ggtacattcc ttccgacttc      180

gctttcaata actggtttct cctgactaac acaagctccg tcgtggatgg cgtggtcagg      240

tcctttcagc ctcttctcct gaattgcctg tggtctgtgt ccgggttaag attcactaca      300

ggcttcgtat acttcaacgg gacgggccgg ggggattgca agggcttctc ctccgacgtg      360

ctgtcagatg tgatccgtta caatctgaac ttcgaagaga acttacggcg ggggacaatc      420

ctgttcaaaa catcatatgg cgtagtcgta ttttactgca ccaataatac cctggtgagt      480

ggggacgccc atattccctt cggaacagtg ctgggtaact tttactgttt tgtcaacact      540

acgatcggaa acgaaaccac tagcgccttt gtcggagctc tgccaaaaac agttagggag      600

ttcgtgatct ctcggaccgg tcacttctat atcaacggct accgttattt tactttgggc      660

aacgtcgaag ccgtcaattt taatgtgaca actgcagaga caactgactt ttgcactgtg      720

gctctcgcca gttatgccga tgtgctggtg aatgtaagtc aaacgtcaat tgccaacatc      780

atctattgta actcagtaat caaccggctc cgctgtgacc aactctcatt cgacgtcccc      840

gacggattct attccacgag cccgattcag agcgtggaac tgccagtttc catcgtatcc      900

ctcccagttt accacaagca cacttttatc gttctctacg tagattttaa accccagtca      960

ggaggaggga aatgcttcaa ctgctacccg gctggcgtga acatcacctt ggccaatttt     1020

aatgaaacta aagggcccct ttgcgtggat acgtcacact ttaccacaaa gtatgttgca     1080

gtctatgcta acgtcggcag gtggtcagcg tccattaaca caggcaattg cccgttctct     1140

ttcgggaaag tgaacaactt cgtgaagttt ggaagtgtgt gcttcagttt gaaagacatt     1200

ccgggcggct gcgccatgcc tattgtggct aattgggctt attccaagta ctacaccatt     1260

ggctctctct acgttagctg gagcgacggt gacggtataa cgggcgtacc acaaccggtg     1320

gaaggggtca gctctttcat gaatgtcact ctggacaagt gtaccaaata taatatatac     1380

gatgtgagtg gagtgggcgt tatacgcgtg tctaacgaca cctttctaaa cggcataacc     1440

tacacaagca cgtcaggcaa tctgttaggt tttaaagacg tcactaaagg cactatatat     1500

agcatcaccc catgcaaccc acctgatcaa ttagtcgtat atcagcaagc tgttgtgggt     1560

gctatgctgt cagaaaactt caccagctac gggttctcca atgtggtgga actgcccaaa     1620

ttcttttacg ctagcaatgg cacatataac tgtactgacg ccgtcttgac ttacagttca     1680

ttcggagtgt gcgcggacgg cagcattatc gccgtgcagc cggccaatgt cagctatgat     1740

tccgtttccg ccatcgtgac agccaacttg tcgattccct ctaactggac aacgtctgtc     1800

caagtcgaat atctgcagat cacctcaacc cccatagtag tcgattgctc aacctacgtc     1860

tgcaacggta atgtcagatg tgtcgagctg ctcaagcagt acacctccgc ctgtaagact     1920

attgaggatg cattaagaaa tagtgcaaga ttggaaagcg ccgatgtgtc ggaaatgcta     1980

accttcgata agaaggcatt cacactggcg aacgtaagct ctttcggcga ttacaacctg     2040

tcttcggtaa tccctagctt gcccacatcc ggctctcggg tggcggggcg gagcgctatc     2100

gaggacattt tattctcgaa actggttaca tctgggctcg gaactgtgga cgccgattac     2160

aagaagtgca ccaagggcct aagcatcgcc gacctcgcct gtgctcagta ctacaacgga     2220

attatggtgc tgccaggtgt cgctgacgca gagcggatgg ctatgtatac cggcagtctc     2280

attggcggga ttgcgttggg cggcctgacg tccgctgtct ccatcccttt ctctctggct     2340

atacaagccc gactgaatta tgtggccctg cagactgatg tcctgcaaga aaatcagaag     2400

attcttgccg ccagcttcaa caaggccatg actaatattg tggatgcgtt taccggagtg     2460

aatgacgcca tcacccaaac gtcccaagcc ctgcagacag tcgccacggc gttaaacaaa     2520

atccaggatg tagtgaatca gcaagggaac agcttgaatc acctgacgtc ccagttaaga     2580

cagaactttc aggcaatcag tagctcaatc caggctatct acgatcgatt agatcctcct     2640

caggcagatc agcaggtgga tcggctcatc accggccgcc tcgcggcatt gaatgttttc     2700

gtaagtcata ccttgaccaa gtacacggag gtgagggcca gtcgccagct ggctcagcaa     2760

aaagtgaatg agtgtgtgaa atcacagagc aaacggtacg ggttttgtgg aaatgggacg     2820

cacatcttta gcatcgttaa tgctgccccc gaagggttag tcttcctgca cactgtgctc     2880

cttcctaccc agtataaaga tgtcgaagca tggtctgggc tctgtgtcga tggaactaac     2940

ggttatgtcc ttcgacagcc aaacctcgct ctctataaag aagggaatta ctataggatc     3000

acctcaagaa tcatgttcga gcccaggata ccaacaatgg ccgattttgt gcagattgaa     3060

aattgtaacg tgacctttgt gaatatcagt cgatccgagc ttcaaacgat tgttcctgag     3120

tacatcgacg tgaataaaac tctacaagag ctgtcctata aactgcctaa ttataccgtg     3180

cctgaccttg tagtcgagca atacaaccag actattctga acctgacatc ggaaatctct     3240

acattggaga ataaaagcgc cgagctcaat tacacagtgc agaagctgca gaccctgatc     3300

gacaatatta acagcactct tgtggactta aagtggctga accgtgtgga gacttacatc     3360

aagtggccct ggtgggtgtg gctctgtatt tccgtggtcc ttatatttgt tgtaagtatg     3420

ctgctcctgt gctgctccaa tggatcgtta caatgcagaa tttgcatttg a              3471


<210>  152
<211>  3480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDI-229E -H1cCT-DNA

<400>  152
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cgcaaacgac taatgggctg aacaccagtt acagcgtctg taacggctgc      120

gtcggatata gcgagaacgt gttcgcagtg gaaagtgggg ggtacattcc ttccgacttc      180

gctttcaata actggtttct cctgactaac acaagctccg tcgtggatgg cgtggtcagg      240

tcctttcagc ctcttctcct gaattgcctg tggtctgtgt ccgggttaag attcactaca      300

ggcttcgtat acttcaacgg gacgggccgg ggggattgca agggcttctc ctccgacgtg      360

ctgtcagatg tgatccgtta caatctgaac ttcgaagaga acttacggcg ggggacaatc      420

ctgttcaaaa catcatatgg cgtagtcgta ttttactgca ccaataatac cctggtgagt      480

ggggacgccc atattccctt cggaacagtg ctgggtaact tttactgttt tgtcaacact      540

acgatcggaa acgaaaccac tagcgccttt gtcggagctc tgccaaaaac agttagggag      600

ttcgtgatct ctcggaccgg tcacttctat atcaacggct accgttattt tactttgggc      660

aacgtcgaag ccgtcaattt taatgtgaca actgcagaga caactgactt ttgcactgtg      720

gctctcgcca gttatgccga tgtgctggtg aatgtaagtc aaacgtcaat tgccaacatc      780

atctattgta actcagtaat caaccggctc cgctgtgacc aactctcatt cgacgtcccc      840

gacggattct attccacgag cccgattcag agcgtggaac tgccagtttc catcgtatcc      900

ctcccagttt accacaagca cacttttatc gttctctacg tagattttaa accccagtca      960

ggaggaggga aatgcttcaa ctgctacccg gctggcgtga acatcacctt ggccaatttt     1020

aatgaaacta aagggcccct ttgcgtggat acgtcacact ttaccacaaa gtatgttgca     1080

gtctatgcta acgtcggcag gtggtcagcg tccattaaca caggcaattg cccgttctct     1140

ttcgggaaag tgaacaactt cgtgaagttt ggaagtgtgt gcttcagttt gaaagacatt     1200

ccgggcggct gcgccatgcc tattgtggct aattgggctt attccaagta ctacaccatt     1260

ggctctctct acgttagctg gagcgacggt gacggtataa cgggcgtacc acaaccggtg     1320

gaaggggtca gctctttcat gaatgtcact ctggacaagt gtaccaaata taatatatac     1380

gatgtgagtg gagtgggcgt tatacgcgtg tctaacgaca cctttctaaa cggcataacc     1440

tacacaagca cgtcaggcaa tctgttaggt tttaaagacg tcactaaagg cactatatat     1500

agcatcaccc catgcaaccc acctgatcaa ttagtcgtat atcagcaagc tgttgtgggt     1560

gctatgctgt cagaaaactt caccagctac gggttctcca atgtggtgga actgcccaaa     1620

ttcttttacg ctagcaatgg cacatataac tgtactgacg ccgtcttgac ttacagttca     1680

ttcggagtgt gcgcggacgg cagcattatc gccgtgcagc cggccaatgt cagctatgat     1740

tccgtttccg ccatcgtgac agccaacttg tcgattccct ctaactggac aacgtctgtc     1800

caagtcgaat atctgcagat cacctcaacc cccatagtag tcgattgctc aacctacgtc     1860

tgcaacggta atgtcagatg tgtcgagctg ctcaagcagt acacctccgc ctgtaagact     1920

attgaggatg cattaagaaa tagtgcaaga ttggaaagcg ccgatgtgtc ggaaatgcta     1980

accttcgata agaaggcatt cacactggcg aacgtaagct ctttcggcga ttacaacctg     2040

tcttcggtaa tccctagctt gcccacatcc ggctctcggg tggcggggcg gagcgctatc     2100

gaggacattt tattctcgaa actggttaca tctgggctcg gaactgtgga cgccgattac     2160

aagaagtgca ccaagggcct aagcatcgcc gacctcgcct gtgctcagta ctacaacgga     2220

attatggtgc tgccaggtgt cgctgacgca gagcggatgg ctatgtatac cggcagtctc     2280

attggcggga ttgcgttggg cggcctgacg tccgctgtct ccatcccttt ctctctggct     2340

atacaagccc gactgaatta tgtggccctg cagactgatg tcctgcaaga aaatcagaag     2400

attcttgccg ccagcttcaa caaggccatg actaatattg tggatgcgtt taccggagtg     2460

aatgacgcca tcacccaaac gtcccaagcc ctgcagacag tcgccacggc gttaaacaaa     2520

atccaggatg tagtgaatca gcaagggaac agcttgaatc acctgacgtc ccagttaaga     2580

cagaactttc aggcaatcag tagctcaatc caggctatct acgatcgatt agatcctcct     2640

caggcagatc agcaggtgga tcggctcatc accggccgcc tcgcggcatt gaatgttttc     2700

gtaagtcata ccttgaccaa gtacacggag gtgagggcca gtcgccagct ggctcagcaa     2760

aaagtgaatg agtgtgtgaa atcacagagc aaacggtacg ggttttgtgg aaatgggacg     2820

cacatcttta gcatcgttaa tgctgccccc gaagggttag tcttcctgca cactgtgctc     2880

cttcctaccc agtataaaga tgtcgaagca tggtctgggc tctgtgtcga tggaactaac     2940

ggttatgtcc ttcgacagcc aaacctcgct ctctataaag aagggaatta ctataggatc     3000

acctcaagaa tcatgttcga gcccaggata ccaacaatgg ccgattttgt gcagattgaa     3060

aattgtaacg tgacctttgt gaatatcagt cgatccgagc ttcaaacgat tgttcctgag     3120

tacatcgacg tgaataaaac tctacaagag ctgtcctata aactgcctaa ttataccgtg     3180

cctgaccttg tagtcgagca atacaaccag actattctga acctgacatc ggaaatctct     3240

acattggaga ataaaagcgc cgagctcaat tacacagtgc agaagctgca gaccctgatc     3300

gacaatatta acagcactct tgtggactta aagtggctga accgtgtgga gacttacatc     3360

aagtggccct ggtgggtgtg gctctgtatt tccgtggtcc ttatatttgt tgtaagtatg     3420

ctgctcctga gcttctggat gtgctctaat gggtctctac agtgtagaat atgtatttga     3480


<210>  153
<211>  1181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-229E -wtTMCT-AA

<400>  153

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Thr Thr Asn Gly Leu Asn Thr 
            20                  25                  30          


Ser Tyr Ser Val Cys Asn Gly Cys Val Gly Tyr Ser Glu Asn Val Phe 
        35                  40                  45              


Ala Val Glu Ser Gly Gly Tyr Ile Pro Ser Asp Phe Ala Phe Asn Asn 
    50                  55                  60                  


Trp Phe Leu Leu Thr Asn Thr Ser Ser Val Val Asp Gly Val Val Arg 
65                  70                  75                  80  


Ser Phe Gln Pro Leu Leu Leu Asn Cys Leu Trp Ser Val Ser Gly Leu 
                85                  90                  95      


Arg Phe Thr Thr Gly Phe Val Tyr Phe Asn Gly Thr Gly Arg Gly Asp 
            100                 105                 110         


Cys Lys Gly Phe Ser Ser Asp Val Leu Ser Asp Val Ile Arg Tyr Asn 
        115                 120                 125             


Leu Asn Phe Glu Glu Asn Leu Arg Arg Gly Thr Ile Leu Phe Lys Thr 
    130                 135                 140                 


Ser Tyr Gly Val Val Val Phe Tyr Cys Thr Asn Asn Thr Leu Val Ser 
145                 150                 155                 160 


Gly Asp Ala His Ile Pro Phe Gly Thr Val Leu Gly Asn Phe Tyr Cys 
                165                 170                 175     


Phe Val Asn Thr Thr Ile Gly Asn Glu Thr Thr Ser Ala Phe Val Gly 
            180                 185                 190         


Ala Leu Pro Lys Thr Val Arg Glu Phe Val Ile Ser Arg Thr Gly His 
        195                 200                 205             


Phe Tyr Ile Asn Gly Tyr Arg Tyr Phe Thr Leu Gly Asn Val Glu Ala 
    210                 215                 220                 


Val Asn Phe Asn Val Thr Thr Ala Glu Thr Thr Asp Phe Cys Thr Val 
225                 230                 235                 240 


Ala Leu Ala Ser Tyr Ala Asp Val Leu Val Asn Val Ser Gln Thr Ser 
                245                 250                 255     


Ile Ala Asn Ile Ile Tyr Cys Asn Ser Val Ile Asn Arg Leu Arg Cys 
            260                 265                 270         


Asp Gln Leu Ser Phe Asp Val Pro Asp Gly Phe Tyr Ser Thr Ser Pro 
        275                 280                 285             


Ile Gln Ser Val Glu Leu Pro Val Ser Ile Val Ser Leu Pro Val Tyr 
    290                 295                 300                 


His Lys His Thr Phe Ile Val Leu Tyr Val Asp Phe Lys Pro Gln Ser 
305                 310                 315                 320 


Gly Gly Gly Lys Cys Phe Asn Cys Tyr Pro Ala Gly Val Asn Ile Thr 
                325                 330                 335     


Leu Ala Asn Phe Asn Glu Thr Lys Gly Pro Leu Cys Val Asp Thr Ser 
            340                 345                 350         


His Phe Thr Thr Lys Tyr Val Ala Val Tyr Ala Asn Val Gly Arg Trp 
        355                 360                 365             


Ser Ala Ser Ile Asn Thr Gly Asn Cys Pro Phe Ser Phe Gly Lys Val 
    370                 375                 380                 


Asn Asn Phe Val Lys Phe Gly Ser Val Cys Phe Ser Leu Lys Asp Ile 
385                 390                 395                 400 


Pro Gly Gly Cys Ala Met Pro Ile Val Ala Asn Trp Ala Tyr Ser Lys 
                405                 410                 415     


Tyr Tyr Thr Ile Gly Ser Leu Tyr Val Ser Trp Ser Asp Gly Asp Gly 
            420                 425                 430         


Ile Thr Gly Val Pro Gln Pro Val Glu Gly Val Ser Ser Phe Met Asn 
        435                 440                 445             


Val Thr Leu Asp Lys Cys Thr Lys Tyr Asn Ile Tyr Asp Val Ser Gly 
    450                 455                 460                 


Val Gly Val Ile Arg Val Ser Asn Asp Thr Phe Leu Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Thr Ser Thr Ser Gly Asn Leu Leu Gly Phe Lys Asp Val Thr Lys 
                485                 490                 495     


Gly Thr Ile Tyr Ser Ile Thr Pro Cys Asn Pro Pro Asp Gln Leu Val 
            500                 505                 510         


Val Tyr Gln Gln Ala Val Val Gly Ala Met Leu Ser Glu Asn Phe Thr 
        515                 520                 525             


Ser Tyr Gly Phe Ser Asn Val Val Glu Leu Pro Lys Phe Phe Tyr Ala 
    530                 535                 540                 


Ser Asn Gly Thr Tyr Asn Cys Thr Asp Ala Val Leu Thr Tyr Ser Ser 
545                 550                 555                 560 


Phe Gly Val Cys Ala Asp Gly Ser Ile Ile Ala Val Gln Pro Ala Asn 
                565                 570                 575     


Val Ser Tyr Asp Ser Val Ser Ala Ile Val Thr Ala Asn Leu Ser Ile 
            580                 585                 590         


Pro Ser Asn Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr 
        595                 600                 605             


Ser Thr Pro Ile Val Val Asp Cys Ser Thr Tyr Val Cys Asn Gly Asn 
    610                 615                 620                 


Val Arg Cys Val Glu Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr 
625                 630                 635                 640 


Ile Glu Asp Ala Leu Arg Asn Ser Ala Arg Leu Glu Ser Ala Asp Val 
                645                 650                 655     


Ser Glu Met Leu Thr Phe Asp Lys Lys Ala Phe Thr Leu Ala Asn Val 
            660                 665                 670         


Ser Ser Phe Gly Asp Tyr Asn Leu Ser Ser Val Ile Pro Ser Leu Pro 
        675                 680                 685             


Thr Ser Gly Ser Arg Val Ala Gly Arg Ser Ala Ile Glu Asp Ile Leu 
    690                 695                 700                 


Phe Ser Lys Leu Val Thr Ser Gly Leu Gly Thr Val Asp Ala Asp Tyr 
705                 710                 715                 720 


Lys Lys Cys Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln 
                725                 730                 735     


Tyr Tyr Asn Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg 
            740                 745                 750         


Met Ala Met Tyr Thr Gly Ser Leu Ile Gly Gly Ile Ala Leu Gly Gly 
        755                 760                 765             


Leu Thr Ser Ala Val Ser Ile Pro Phe Ser Leu Ala Ile Gln Ala Arg 
    770                 775                 780                 


Leu Asn Tyr Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys 
785                 790                 795                 800 


Ile Leu Ala Ala Ser Phe Asn Lys Ala Met Thr Asn Ile Val Asp Ala 
                805                 810                 815     


Phe Thr Gly Val Asn Asp Ala Ile Thr Gln Thr Ser Gln Ala Leu Gln 
            820                 825                 830         


Thr Val Ala Thr Ala Leu Asn Lys Ile Gln Asp Val Val Asn Gln Gln 
        835                 840                 845             


Gly Asn Ser Leu Asn His Leu Thr Ser Gln Leu Arg Gln Asn Phe Gln 
    850                 855                 860                 


Ala Ile Ser Ser Ser Ile Gln Ala Ile Tyr Asp Arg Leu Asp Pro Pro 
865                 870                 875                 880 


Gln Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ala Ala 
                885                 890                 895     


Leu Asn Val Phe Val Ser His Thr Leu Thr Lys Tyr Thr Glu Val Arg 
            900                 905                 910         


Ala Ser Arg Gln Leu Ala Gln Gln Lys Val Asn Glu Cys Val Lys Ser 
        915                 920                 925             


Gln Ser Lys Arg Tyr Gly Phe Cys Gly Asn Gly Thr His Ile Phe Ser 
    930                 935                 940                 


Ile Val Asn Ala Ala Pro Glu Gly Leu Val Phe Leu His Thr Val Leu 
945                 950                 955                 960 


Leu Pro Thr Gln Tyr Lys Asp Val Glu Ala Trp Ser Gly Leu Cys Val 
                965                 970                 975     


Asp Gly Thr Asn Gly Tyr Val Leu Arg Gln Pro Asn Leu Ala Leu Tyr 
            980                 985                 990         


Lys Glu Gly Asn Tyr Tyr Arg Ile  Thr Ser Arg Ile Met  Phe Glu Pro 
        995                 1000                 1005             


Arg Ile  Pro Thr Met Ala Asp  Phe Val Gln Ile Glu  Asn Cys Asn 
    1010                 1015                 1020             


Val Thr  Phe Val Asn Ile Ser  Arg Ser Glu Leu Gln  Thr Ile Val 
    1025                 1030                 1035             


Pro Glu  Tyr Ile Asp Val Asn  Lys Thr Leu Gln Glu  Leu Ser Tyr 
    1040                 1045                 1050             


Lys Leu  Pro Asn Tyr Thr Val  Pro Asp Leu Val Val  Glu Gln Tyr 
    1055                 1060                 1065             


Asn Gln  Thr Ile Leu Asn Leu  Thr Ser Glu Ile Ser  Thr Leu Glu 
    1070                 1075                 1080             


Asn Lys  Ser Ala Glu Leu Asn  Tyr Thr Val Gln Lys  Leu Gln Thr 
    1085                 1090                 1095             


Leu Ile  Asp Asn Ile Asn Ser  Thr Leu Val Asp Leu  Lys Trp Leu 
    1100                 1105                 1110             


Asn Arg  Val Glu Thr Tyr Ile  Lys Trp Pro Trp Trp  Val Trp Leu 
    1115                 1120                 1125             


Cys Ile  Ser Val Val Leu Ile  Phe Val Val Ser Met  Leu Leu Leu 
    1130                 1135                 1140             


Cys Cys  Cys Ser Thr Gly Cys  Cys Gly Phe Phe Ser  Cys Phe Ala 
    1145                 1150                 1155             


Ser Ser  Ile Arg Gly Cys Cys  Glu Ser Thr Lys Leu  Pro Tyr Tyr 
    1160                 1165                 1170             


Asp Val  Glu Lys Ile His Ile  Gln 
    1175                 1180     


<210>  154
<211>  1163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-229E -H5iTMCT-AA

<400>  154

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Thr Thr Asn Gly Leu Asn Thr 
            20                  25                  30          


Ser Tyr Ser Val Cys Asn Gly Cys Val Gly Tyr Ser Glu Asn Val Phe 
        35                  40                  45              


Ala Val Glu Ser Gly Gly Tyr Ile Pro Ser Asp Phe Ala Phe Asn Asn 
    50                  55                  60                  


Trp Phe Leu Leu Thr Asn Thr Ser Ser Val Val Asp Gly Val Val Arg 
65                  70                  75                  80  


Ser Phe Gln Pro Leu Leu Leu Asn Cys Leu Trp Ser Val Ser Gly Leu 
                85                  90                  95      


Arg Phe Thr Thr Gly Phe Val Tyr Phe Asn Gly Thr Gly Arg Gly Asp 
            100                 105                 110         


Cys Lys Gly Phe Ser Ser Asp Val Leu Ser Asp Val Ile Arg Tyr Asn 
        115                 120                 125             


Leu Asn Phe Glu Glu Asn Leu Arg Arg Gly Thr Ile Leu Phe Lys Thr 
    130                 135                 140                 


Ser Tyr Gly Val Val Val Phe Tyr Cys Thr Asn Asn Thr Leu Val Ser 
145                 150                 155                 160 


Gly Asp Ala His Ile Pro Phe Gly Thr Val Leu Gly Asn Phe Tyr Cys 
                165                 170                 175     


Phe Val Asn Thr Thr Ile Gly Asn Glu Thr Thr Ser Ala Phe Val Gly 
            180                 185                 190         


Ala Leu Pro Lys Thr Val Arg Glu Phe Val Ile Ser Arg Thr Gly His 
        195                 200                 205             


Phe Tyr Ile Asn Gly Tyr Arg Tyr Phe Thr Leu Gly Asn Val Glu Ala 
    210                 215                 220                 


Val Asn Phe Asn Val Thr Thr Ala Glu Thr Thr Asp Phe Cys Thr Val 
225                 230                 235                 240 


Ala Leu Ala Ser Tyr Ala Asp Val Leu Val Asn Val Ser Gln Thr Ser 
                245                 250                 255     


Ile Ala Asn Ile Ile Tyr Cys Asn Ser Val Ile Asn Arg Leu Arg Cys 
            260                 265                 270         


Asp Gln Leu Ser Phe Asp Val Pro Asp Gly Phe Tyr Ser Thr Ser Pro 
        275                 280                 285             


Ile Gln Ser Val Glu Leu Pro Val Ser Ile Val Ser Leu Pro Val Tyr 
    290                 295                 300                 


His Lys His Thr Phe Ile Val Leu Tyr Val Asp Phe Lys Pro Gln Ser 
305                 310                 315                 320 


Gly Gly Gly Lys Cys Phe Asn Cys Tyr Pro Ala Gly Val Asn Ile Thr 
                325                 330                 335     


Leu Ala Asn Phe Asn Glu Thr Lys Gly Pro Leu Cys Val Asp Thr Ser 
            340                 345                 350         


His Phe Thr Thr Lys Tyr Val Ala Val Tyr Ala Asn Val Gly Arg Trp 
        355                 360                 365             


Ser Ala Ser Ile Asn Thr Gly Asn Cys Pro Phe Ser Phe Gly Lys Val 
    370                 375                 380                 


Asn Asn Phe Val Lys Phe Gly Ser Val Cys Phe Ser Leu Lys Asp Ile 
385                 390                 395                 400 


Pro Gly Gly Cys Ala Met Pro Ile Val Ala Asn Trp Ala Tyr Ser Lys 
                405                 410                 415     


Tyr Tyr Thr Ile Gly Ser Leu Tyr Val Ser Trp Ser Asp Gly Asp Gly 
            420                 425                 430         


Ile Thr Gly Val Pro Gln Pro Val Glu Gly Val Ser Ser Phe Met Asn 
        435                 440                 445             


Val Thr Leu Asp Lys Cys Thr Lys Tyr Asn Ile Tyr Asp Val Ser Gly 
    450                 455                 460                 


Val Gly Val Ile Arg Val Ser Asn Asp Thr Phe Leu Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Thr Ser Thr Ser Gly Asn Leu Leu Gly Phe Lys Asp Val Thr Lys 
                485                 490                 495     


Gly Thr Ile Tyr Ser Ile Thr Pro Cys Asn Pro Pro Asp Gln Leu Val 
            500                 505                 510         


Val Tyr Gln Gln Ala Val Val Gly Ala Met Leu Ser Glu Asn Phe Thr 
        515                 520                 525             


Ser Tyr Gly Phe Ser Asn Val Val Glu Leu Pro Lys Phe Phe Tyr Ala 
    530                 535                 540                 


Ser Asn Gly Thr Tyr Asn Cys Thr Asp Ala Val Leu Thr Tyr Ser Ser 
545                 550                 555                 560 


Phe Gly Val Cys Ala Asp Gly Ser Ile Ile Ala Val Gln Pro Ala Asn 
                565                 570                 575     


Val Ser Tyr Asp Ser Val Ser Ala Ile Val Thr Ala Asn Leu Ser Ile 
            580                 585                 590         


Pro Ser Asn Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr 
        595                 600                 605             


Ser Thr Pro Ile Val Val Asp Cys Ser Thr Tyr Val Cys Asn Gly Asn 
    610                 615                 620                 


Val Arg Cys Val Glu Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr 
625                 630                 635                 640 


Ile Glu Asp Ala Leu Arg Asn Ser Ala Arg Leu Glu Ser Ala Asp Val 
                645                 650                 655     


Ser Glu Met Leu Thr Phe Asp Lys Lys Ala Phe Thr Leu Ala Asn Val 
            660                 665                 670         


Ser Ser Phe Gly Asp Tyr Asn Leu Ser Ser Val Ile Pro Ser Leu Pro 
        675                 680                 685             


Thr Ser Gly Ser Arg Val Ala Gly Arg Ser Ala Ile Glu Asp Ile Leu 
    690                 695                 700                 


Phe Ser Lys Leu Val Thr Ser Gly Leu Gly Thr Val Asp Ala Asp Tyr 
705                 710                 715                 720 


Lys Lys Cys Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln 
                725                 730                 735     


Tyr Tyr Asn Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg 
            740                 745                 750         


Met Ala Met Tyr Thr Gly Ser Leu Ile Gly Gly Ile Ala Leu Gly Gly 
        755                 760                 765             


Leu Thr Ser Ala Val Ser Ile Pro Phe Ser Leu Ala Ile Gln Ala Arg 
    770                 775                 780                 


Leu Asn Tyr Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys 
785                 790                 795                 800 


Ile Leu Ala Ala Ser Phe Asn Lys Ala Met Thr Asn Ile Val Asp Ala 
                805                 810                 815     


Phe Thr Gly Val Asn Asp Ala Ile Thr Gln Thr Ser Gln Ala Leu Gln 
            820                 825                 830         


Thr Val Ala Thr Ala Leu Asn Lys Ile Gln Asp Val Val Asn Gln Gln 
        835                 840                 845             


Gly Asn Ser Leu Asn His Leu Thr Ser Gln Leu Arg Gln Asn Phe Gln 
    850                 855                 860                 


Ala Ile Ser Ser Ser Ile Gln Ala Ile Tyr Asp Arg Leu Asp Pro Pro 
865                 870                 875                 880 


Gln Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ala Ala 
                885                 890                 895     


Leu Asn Val Phe Val Ser His Thr Leu Thr Lys Tyr Thr Glu Val Arg 
            900                 905                 910         


Ala Ser Arg Gln Leu Ala Gln Gln Lys Val Asn Glu Cys Val Lys Ser 
        915                 920                 925             


Gln Ser Lys Arg Tyr Gly Phe Cys Gly Asn Gly Thr His Ile Phe Ser 
    930                 935                 940                 


Ile Val Asn Ala Ala Pro Glu Gly Leu Val Phe Leu His Thr Val Leu 
945                 950                 955                 960 


Leu Pro Thr Gln Tyr Lys Asp Val Glu Ala Trp Ser Gly Leu Cys Val 
                965                 970                 975     


Asp Gly Thr Asn Gly Tyr Val Leu Arg Gln Pro Asn Leu Ala Leu Tyr 
            980                 985                 990         


Lys Glu Gly Asn Tyr Tyr Arg Ile  Thr Ser Arg Ile Met  Phe Glu Pro 
        995                 1000                 1005             


Arg Ile  Pro Thr Met Ala Asp  Phe Val Gln Ile Glu  Asn Cys Asn 
    1010                 1015                 1020             


Val Thr  Phe Val Asn Ile Ser  Arg Ser Glu Leu Gln  Thr Ile Val 
    1025                 1030                 1035             


Pro Glu  Tyr Ile Asp Val Asn  Lys Thr Leu Gln Glu  Leu Ser Tyr 
    1040                 1045                 1050             


Lys Leu  Pro Asn Tyr Thr Val  Pro Asp Leu Val Val  Glu Gln Tyr 
    1055                 1060                 1065             


Asn Gln  Thr Ile Leu Asn Leu  Thr Ser Glu Ile Ser  Thr Leu Glu 
    1070                 1075                 1080             


Asn Lys  Ser Ala Glu Leu Asn  Tyr Thr Val Gln Lys  Leu Gln Thr 
    1085                 1090                 1095             


Leu Ile  Asp Asn Ile Asn Ser  Thr Leu Val Asp Leu  Lys Trp Leu 
    1100                 1105                 1110             


Asn Arg  Val Glu Thr Tyr Ile  Lys Trp Pro Trp Trp  Gln Ile Leu 
    1115                 1120                 1125             


Ser Ile  Tyr Ser Thr Val Ala  Ser Ser Leu Ala Leu  Ala Ile Met 
    1130                 1135                 1140             


Met Ala  Gly Leu Ser Leu Trp  Met Cys Ser Asn Gly  Ser Leu Gln 
    1145                 1150                 1155             


Cys Arg  Ile Cys Ile 
    1160             


<210>  155
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-229E -H5iCT-AA

<400>  155

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Thr Thr Asn Gly Leu Asn Thr 
            20                  25                  30          


Ser Tyr Ser Val Cys Asn Gly Cys Val Gly Tyr Ser Glu Asn Val Phe 
        35                  40                  45              


Ala Val Glu Ser Gly Gly Tyr Ile Pro Ser Asp Phe Ala Phe Asn Asn 
    50                  55                  60                  


Trp Phe Leu Leu Thr Asn Thr Ser Ser Val Val Asp Gly Val Val Arg 
65                  70                  75                  80  


Ser Phe Gln Pro Leu Leu Leu Asn Cys Leu Trp Ser Val Ser Gly Leu 
                85                  90                  95      


Arg Phe Thr Thr Gly Phe Val Tyr Phe Asn Gly Thr Gly Arg Gly Asp 
            100                 105                 110         


Cys Lys Gly Phe Ser Ser Asp Val Leu Ser Asp Val Ile Arg Tyr Asn 
        115                 120                 125             


Leu Asn Phe Glu Glu Asn Leu Arg Arg Gly Thr Ile Leu Phe Lys Thr 
    130                 135                 140                 


Ser Tyr Gly Val Val Val Phe Tyr Cys Thr Asn Asn Thr Leu Val Ser 
145                 150                 155                 160 


Gly Asp Ala His Ile Pro Phe Gly Thr Val Leu Gly Asn Phe Tyr Cys 
                165                 170                 175     


Phe Val Asn Thr Thr Ile Gly Asn Glu Thr Thr Ser Ala Phe Val Gly 
            180                 185                 190         


Ala Leu Pro Lys Thr Val Arg Glu Phe Val Ile Ser Arg Thr Gly His 
        195                 200                 205             


Phe Tyr Ile Asn Gly Tyr Arg Tyr Phe Thr Leu Gly Asn Val Glu Ala 
    210                 215                 220                 


Val Asn Phe Asn Val Thr Thr Ala Glu Thr Thr Asp Phe Cys Thr Val 
225                 230                 235                 240 


Ala Leu Ala Ser Tyr Ala Asp Val Leu Val Asn Val Ser Gln Thr Ser 
                245                 250                 255     


Ile Ala Asn Ile Ile Tyr Cys Asn Ser Val Ile Asn Arg Leu Arg Cys 
            260                 265                 270         


Asp Gln Leu Ser Phe Asp Val Pro Asp Gly Phe Tyr Ser Thr Ser Pro 
        275                 280                 285             


Ile Gln Ser Val Glu Leu Pro Val Ser Ile Val Ser Leu Pro Val Tyr 
    290                 295                 300                 


His Lys His Thr Phe Ile Val Leu Tyr Val Asp Phe Lys Pro Gln Ser 
305                 310                 315                 320 


Gly Gly Gly Lys Cys Phe Asn Cys Tyr Pro Ala Gly Val Asn Ile Thr 
                325                 330                 335     


Leu Ala Asn Phe Asn Glu Thr Lys Gly Pro Leu Cys Val Asp Thr Ser 
            340                 345                 350         


His Phe Thr Thr Lys Tyr Val Ala Val Tyr Ala Asn Val Gly Arg Trp 
        355                 360                 365             


Ser Ala Ser Ile Asn Thr Gly Asn Cys Pro Phe Ser Phe Gly Lys Val 
    370                 375                 380                 


Asn Asn Phe Val Lys Phe Gly Ser Val Cys Phe Ser Leu Lys Asp Ile 
385                 390                 395                 400 


Pro Gly Gly Cys Ala Met Pro Ile Val Ala Asn Trp Ala Tyr Ser Lys 
                405                 410                 415     


Tyr Tyr Thr Ile Gly Ser Leu Tyr Val Ser Trp Ser Asp Gly Asp Gly 
            420                 425                 430         


Ile Thr Gly Val Pro Gln Pro Val Glu Gly Val Ser Ser Phe Met Asn 
        435                 440                 445             


Val Thr Leu Asp Lys Cys Thr Lys Tyr Asn Ile Tyr Asp Val Ser Gly 
    450                 455                 460                 


Val Gly Val Ile Arg Val Ser Asn Asp Thr Phe Leu Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Thr Ser Thr Ser Gly Asn Leu Leu Gly Phe Lys Asp Val Thr Lys 
                485                 490                 495     


Gly Thr Ile Tyr Ser Ile Thr Pro Cys Asn Pro Pro Asp Gln Leu Val 
            500                 505                 510         


Val Tyr Gln Gln Ala Val Val Gly Ala Met Leu Ser Glu Asn Phe Thr 
        515                 520                 525             


Ser Tyr Gly Phe Ser Asn Val Val Glu Leu Pro Lys Phe Phe Tyr Ala 
    530                 535                 540                 


Ser Asn Gly Thr Tyr Asn Cys Thr Asp Ala Val Leu Thr Tyr Ser Ser 
545                 550                 555                 560 


Phe Gly Val Cys Ala Asp Gly Ser Ile Ile Ala Val Gln Pro Ala Asn 
                565                 570                 575     


Val Ser Tyr Asp Ser Val Ser Ala Ile Val Thr Ala Asn Leu Ser Ile 
            580                 585                 590         


Pro Ser Asn Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr 
        595                 600                 605             


Ser Thr Pro Ile Val Val Asp Cys Ser Thr Tyr Val Cys Asn Gly Asn 
    610                 615                 620                 


Val Arg Cys Val Glu Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr 
625                 630                 635                 640 


Ile Glu Asp Ala Leu Arg Asn Ser Ala Arg Leu Glu Ser Ala Asp Val 
                645                 650                 655     


Ser Glu Met Leu Thr Phe Asp Lys Lys Ala Phe Thr Leu Ala Asn Val 
            660                 665                 670         


Ser Ser Phe Gly Asp Tyr Asn Leu Ser Ser Val Ile Pro Ser Leu Pro 
        675                 680                 685             


Thr Ser Gly Ser Arg Val Ala Gly Arg Ser Ala Ile Glu Asp Ile Leu 
    690                 695                 700                 


Phe Ser Lys Leu Val Thr Ser Gly Leu Gly Thr Val Asp Ala Asp Tyr 
705                 710                 715                 720 


Lys Lys Cys Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln 
                725                 730                 735     


Tyr Tyr Asn Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg 
            740                 745                 750         


Met Ala Met Tyr Thr Gly Ser Leu Ile Gly Gly Ile Ala Leu Gly Gly 
        755                 760                 765             


Leu Thr Ser Ala Val Ser Ile Pro Phe Ser Leu Ala Ile Gln Ala Arg 
    770                 775                 780                 


Leu Asn Tyr Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys 
785                 790                 795                 800 


Ile Leu Ala Ala Ser Phe Asn Lys Ala Met Thr Asn Ile Val Asp Ala 
                805                 810                 815     


Phe Thr Gly Val Asn Asp Ala Ile Thr Gln Thr Ser Gln Ala Leu Gln 
            820                 825                 830         


Thr Val Ala Thr Ala Leu Asn Lys Ile Gln Asp Val Val Asn Gln Gln 
        835                 840                 845             


Gly Asn Ser Leu Asn His Leu Thr Ser Gln Leu Arg Gln Asn Phe Gln 
    850                 855                 860                 


Ala Ile Ser Ser Ser Ile Gln Ala Ile Tyr Asp Arg Leu Asp Pro Pro 
865                 870                 875                 880 


Gln Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ala Ala 
                885                 890                 895     


Leu Asn Val Phe Val Ser His Thr Leu Thr Lys Tyr Thr Glu Val Arg 
            900                 905                 910         


Ala Ser Arg Gln Leu Ala Gln Gln Lys Val Asn Glu Cys Val Lys Ser 
        915                 920                 925             


Gln Ser Lys Arg Tyr Gly Phe Cys Gly Asn Gly Thr His Ile Phe Ser 
    930                 935                 940                 


Ile Val Asn Ala Ala Pro Glu Gly Leu Val Phe Leu His Thr Val Leu 
945                 950                 955                 960 


Leu Pro Thr Gln Tyr Lys Asp Val Glu Ala Trp Ser Gly Leu Cys Val 
                965                 970                 975     


Asp Gly Thr Asn Gly Tyr Val Leu Arg Gln Pro Asn Leu Ala Leu Tyr 
            980                 985                 990         


Lys Glu Gly Asn Tyr Tyr Arg Ile  Thr Ser Arg Ile Met  Phe Glu Pro 
        995                 1000                 1005             


Arg Ile  Pro Thr Met Ala Asp  Phe Val Gln Ile Glu  Asn Cys Asn 
    1010                 1015                 1020             


Val Thr  Phe Val Asn Ile Ser  Arg Ser Glu Leu Gln  Thr Ile Val 
    1025                 1030                 1035             


Pro Glu  Tyr Ile Asp Val Asn  Lys Thr Leu Gln Glu  Leu Ser Tyr 
    1040                 1045                 1050             


Lys Leu  Pro Asn Tyr Thr Val  Pro Asp Leu Val Val  Glu Gln Tyr 
    1055                 1060                 1065             


Asn Gln  Thr Ile Leu Asn Leu  Thr Ser Glu Ile Ser  Thr Leu Glu 
    1070                 1075                 1080             


Asn Lys  Ser Ala Glu Leu Asn  Tyr Thr Val Gln Lys  Leu Gln Thr 
    1085                 1090                 1095             


Leu Ile  Asp Asn Ile Asn Ser  Thr Leu Val Asp Leu  Lys Trp Leu 
    1100                 1105                 1110             


Asn Arg  Val Glu Thr Tyr Ile  Lys Trp Pro Trp Trp  Val Trp Leu 
    1115                 1120                 1125             


Cys Ile  Ser Val Val Leu Ile  Phe Val Val Ser Met  Leu Leu Leu 
    1130                 1135                 1140             


Ser Leu  Trp Met Cys Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys 
    1145                 1150                 1155             


Ile 
    


<210>  156
<211>  1156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-229E -H5iCT(V4)-AA

<400>  156

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Thr Thr Asn Gly Leu Asn Thr 
            20                  25                  30          


Ser Tyr Ser Val Cys Asn Gly Cys Val Gly Tyr Ser Glu Asn Val Phe 
        35                  40                  45              


Ala Val Glu Ser Gly Gly Tyr Ile Pro Ser Asp Phe Ala Phe Asn Asn 
    50                  55                  60                  


Trp Phe Leu Leu Thr Asn Thr Ser Ser Val Val Asp Gly Val Val Arg 
65                  70                  75                  80  


Ser Phe Gln Pro Leu Leu Leu Asn Cys Leu Trp Ser Val Ser Gly Leu 
                85                  90                  95      


Arg Phe Thr Thr Gly Phe Val Tyr Phe Asn Gly Thr Gly Arg Gly Asp 
            100                 105                 110         


Cys Lys Gly Phe Ser Ser Asp Val Leu Ser Asp Val Ile Arg Tyr Asn 
        115                 120                 125             


Leu Asn Phe Glu Glu Asn Leu Arg Arg Gly Thr Ile Leu Phe Lys Thr 
    130                 135                 140                 


Ser Tyr Gly Val Val Val Phe Tyr Cys Thr Asn Asn Thr Leu Val Ser 
145                 150                 155                 160 


Gly Asp Ala His Ile Pro Phe Gly Thr Val Leu Gly Asn Phe Tyr Cys 
                165                 170                 175     


Phe Val Asn Thr Thr Ile Gly Asn Glu Thr Thr Ser Ala Phe Val Gly 
            180                 185                 190         


Ala Leu Pro Lys Thr Val Arg Glu Phe Val Ile Ser Arg Thr Gly His 
        195                 200                 205             


Phe Tyr Ile Asn Gly Tyr Arg Tyr Phe Thr Leu Gly Asn Val Glu Ala 
    210                 215                 220                 


Val Asn Phe Asn Val Thr Thr Ala Glu Thr Thr Asp Phe Cys Thr Val 
225                 230                 235                 240 


Ala Leu Ala Ser Tyr Ala Asp Val Leu Val Asn Val Ser Gln Thr Ser 
                245                 250                 255     


Ile Ala Asn Ile Ile Tyr Cys Asn Ser Val Ile Asn Arg Leu Arg Cys 
            260                 265                 270         


Asp Gln Leu Ser Phe Asp Val Pro Asp Gly Phe Tyr Ser Thr Ser Pro 
        275                 280                 285             


Ile Gln Ser Val Glu Leu Pro Val Ser Ile Val Ser Leu Pro Val Tyr 
    290                 295                 300                 


His Lys His Thr Phe Ile Val Leu Tyr Val Asp Phe Lys Pro Gln Ser 
305                 310                 315                 320 


Gly Gly Gly Lys Cys Phe Asn Cys Tyr Pro Ala Gly Val Asn Ile Thr 
                325                 330                 335     


Leu Ala Asn Phe Asn Glu Thr Lys Gly Pro Leu Cys Val Asp Thr Ser 
            340                 345                 350         


His Phe Thr Thr Lys Tyr Val Ala Val Tyr Ala Asn Val Gly Arg Trp 
        355                 360                 365             


Ser Ala Ser Ile Asn Thr Gly Asn Cys Pro Phe Ser Phe Gly Lys Val 
    370                 375                 380                 


Asn Asn Phe Val Lys Phe Gly Ser Val Cys Phe Ser Leu Lys Asp Ile 
385                 390                 395                 400 


Pro Gly Gly Cys Ala Met Pro Ile Val Ala Asn Trp Ala Tyr Ser Lys 
                405                 410                 415     


Tyr Tyr Thr Ile Gly Ser Leu Tyr Val Ser Trp Ser Asp Gly Asp Gly 
            420                 425                 430         


Ile Thr Gly Val Pro Gln Pro Val Glu Gly Val Ser Ser Phe Met Asn 
        435                 440                 445             


Val Thr Leu Asp Lys Cys Thr Lys Tyr Asn Ile Tyr Asp Val Ser Gly 
    450                 455                 460                 


Val Gly Val Ile Arg Val Ser Asn Asp Thr Phe Leu Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Thr Ser Thr Ser Gly Asn Leu Leu Gly Phe Lys Asp Val Thr Lys 
                485                 490                 495     


Gly Thr Ile Tyr Ser Ile Thr Pro Cys Asn Pro Pro Asp Gln Leu Val 
            500                 505                 510         


Val Tyr Gln Gln Ala Val Val Gly Ala Met Leu Ser Glu Asn Phe Thr 
        515                 520                 525             


Ser Tyr Gly Phe Ser Asn Val Val Glu Leu Pro Lys Phe Phe Tyr Ala 
    530                 535                 540                 


Ser Asn Gly Thr Tyr Asn Cys Thr Asp Ala Val Leu Thr Tyr Ser Ser 
545                 550                 555                 560 


Phe Gly Val Cys Ala Asp Gly Ser Ile Ile Ala Val Gln Pro Ala Asn 
                565                 570                 575     


Val Ser Tyr Asp Ser Val Ser Ala Ile Val Thr Ala Asn Leu Ser Ile 
            580                 585                 590         


Pro Ser Asn Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr 
        595                 600                 605             


Ser Thr Pro Ile Val Val Asp Cys Ser Thr Tyr Val Cys Asn Gly Asn 
    610                 615                 620                 


Val Arg Cys Val Glu Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr 
625                 630                 635                 640 


Ile Glu Asp Ala Leu Arg Asn Ser Ala Arg Leu Glu Ser Ala Asp Val 
                645                 650                 655     


Ser Glu Met Leu Thr Phe Asp Lys Lys Ala Phe Thr Leu Ala Asn Val 
            660                 665                 670         


Ser Ser Phe Gly Asp Tyr Asn Leu Ser Ser Val Ile Pro Ser Leu Pro 
        675                 680                 685             


Thr Ser Gly Ser Arg Val Ala Gly Arg Ser Ala Ile Glu Asp Ile Leu 
    690                 695                 700                 


Phe Ser Lys Leu Val Thr Ser Gly Leu Gly Thr Val Asp Ala Asp Tyr 
705                 710                 715                 720 


Lys Lys Cys Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln 
                725                 730                 735     


Tyr Tyr Asn Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg 
            740                 745                 750         


Met Ala Met Tyr Thr Gly Ser Leu Ile Gly Gly Ile Ala Leu Gly Gly 
        755                 760                 765             


Leu Thr Ser Ala Val Ser Ile Pro Phe Ser Leu Ala Ile Gln Ala Arg 
    770                 775                 780                 


Leu Asn Tyr Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys 
785                 790                 795                 800 


Ile Leu Ala Ala Ser Phe Asn Lys Ala Met Thr Asn Ile Val Asp Ala 
                805                 810                 815     


Phe Thr Gly Val Asn Asp Ala Ile Thr Gln Thr Ser Gln Ala Leu Gln 
            820                 825                 830         


Thr Val Ala Thr Ala Leu Asn Lys Ile Gln Asp Val Val Asn Gln Gln 
        835                 840                 845             


Gly Asn Ser Leu Asn His Leu Thr Ser Gln Leu Arg Gln Asn Phe Gln 
    850                 855                 860                 


Ala Ile Ser Ser Ser Ile Gln Ala Ile Tyr Asp Arg Leu Asp Pro Pro 
865                 870                 875                 880 


Gln Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ala Ala 
                885                 890                 895     


Leu Asn Val Phe Val Ser His Thr Leu Thr Lys Tyr Thr Glu Val Arg 
            900                 905                 910         


Ala Ser Arg Gln Leu Ala Gln Gln Lys Val Asn Glu Cys Val Lys Ser 
        915                 920                 925             


Gln Ser Lys Arg Tyr Gly Phe Cys Gly Asn Gly Thr His Ile Phe Ser 
    930                 935                 940                 


Ile Val Asn Ala Ala Pro Glu Gly Leu Val Phe Leu His Thr Val Leu 
945                 950                 955                 960 


Leu Pro Thr Gln Tyr Lys Asp Val Glu Ala Trp Ser Gly Leu Cys Val 
                965                 970                 975     


Asp Gly Thr Asn Gly Tyr Val Leu Arg Gln Pro Asn Leu Ala Leu Tyr 
            980                 985                 990         


Lys Glu Gly Asn Tyr Tyr Arg Ile  Thr Ser Arg Ile Met  Phe Glu Pro 
        995                 1000                 1005             


Arg Ile  Pro Thr Met Ala Asp  Phe Val Gln Ile Glu  Asn Cys Asn 
    1010                 1015                 1020             


Val Thr  Phe Val Asn Ile Ser  Arg Ser Glu Leu Gln  Thr Ile Val 
    1025                 1030                 1035             


Pro Glu  Tyr Ile Asp Val Asn  Lys Thr Leu Gln Glu  Leu Ser Tyr 
    1040                 1045                 1050             


Lys Leu  Pro Asn Tyr Thr Val  Pro Asp Leu Val Val  Glu Gln Tyr 
    1055                 1060                 1065             


Asn Gln  Thr Ile Leu Asn Leu  Thr Ser Glu Ile Ser  Thr Leu Glu 
    1070                 1075                 1080             


Asn Lys  Ser Ala Glu Leu Asn  Tyr Thr Val Gln Lys  Leu Gln Thr 
    1085                 1090                 1095             


Leu Ile  Asp Asn Ile Asn Ser  Thr Leu Val Asp Leu  Lys Trp Leu 
    1100                 1105                 1110             


Asn Arg  Val Glu Thr Tyr Ile  Lys Trp Pro Trp Trp  Val Trp Leu 
    1115                 1120                 1125             


Cys Ile  Ser Val Val Leu Ile  Phe Val Val Ser Met  Leu Leu Leu 
    1130                 1135                 1140             


Cys Cys  Ser Asn Gly Ser Leu  Gln Cys Arg Ile Cys  Ile 
    1145                 1150                 1155     


<210>  157
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDI-229E-H1cCT-AA

<400>  157

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Thr Thr Asn Gly Leu Asn Thr 
            20                  25                  30          


Ser Tyr Ser Val Cys Asn Gly Cys Val Gly Tyr Ser Glu Asn Val Phe 
        35                  40                  45              


Ala Val Glu Ser Gly Gly Tyr Ile Pro Ser Asp Phe Ala Phe Asn Asn 
    50                  55                  60                  


Trp Phe Leu Leu Thr Asn Thr Ser Ser Val Val Asp Gly Val Val Arg 
65                  70                  75                  80  


Ser Phe Gln Pro Leu Leu Leu Asn Cys Leu Trp Ser Val Ser Gly Leu 
                85                  90                  95      


Arg Phe Thr Thr Gly Phe Val Tyr Phe Asn Gly Thr Gly Arg Gly Asp 
            100                 105                 110         


Cys Lys Gly Phe Ser Ser Asp Val Leu Ser Asp Val Ile Arg Tyr Asn 
        115                 120                 125             


Leu Asn Phe Glu Glu Asn Leu Arg Arg Gly Thr Ile Leu Phe Lys Thr 
    130                 135                 140                 


Ser Tyr Gly Val Val Val Phe Tyr Cys Thr Asn Asn Thr Leu Val Ser 
145                 150                 155                 160 


Gly Asp Ala His Ile Pro Phe Gly Thr Val Leu Gly Asn Phe Tyr Cys 
                165                 170                 175     


Phe Val Asn Thr Thr Ile Gly Asn Glu Thr Thr Ser Ala Phe Val Gly 
            180                 185                 190         


Ala Leu Pro Lys Thr Val Arg Glu Phe Val Ile Ser Arg Thr Gly His 
        195                 200                 205             


Phe Tyr Ile Asn Gly Tyr Arg Tyr Phe Thr Leu Gly Asn Val Glu Ala 
    210                 215                 220                 


Val Asn Phe Asn Val Thr Thr Ala Glu Thr Thr Asp Phe Cys Thr Val 
225                 230                 235                 240 


Ala Leu Ala Ser Tyr Ala Asp Val Leu Val Asn Val Ser Gln Thr Ser 
                245                 250                 255     


Ile Ala Asn Ile Ile Tyr Cys Asn Ser Val Ile Asn Arg Leu Arg Cys 
            260                 265                 270         


Asp Gln Leu Ser Phe Asp Val Pro Asp Gly Phe Tyr Ser Thr Ser Pro 
        275                 280                 285             


Ile Gln Ser Val Glu Leu Pro Val Ser Ile Val Ser Leu Pro Val Tyr 
    290                 295                 300                 


His Lys His Thr Phe Ile Val Leu Tyr Val Asp Phe Lys Pro Gln Ser 
305                 310                 315                 320 


Gly Gly Gly Lys Cys Phe Asn Cys Tyr Pro Ala Gly Val Asn Ile Thr 
                325                 330                 335     


Leu Ala Asn Phe Asn Glu Thr Lys Gly Pro Leu Cys Val Asp Thr Ser 
            340                 345                 350         


His Phe Thr Thr Lys Tyr Val Ala Val Tyr Ala Asn Val Gly Arg Trp 
        355                 360                 365             


Ser Ala Ser Ile Asn Thr Gly Asn Cys Pro Phe Ser Phe Gly Lys Val 
    370                 375                 380                 


Asn Asn Phe Val Lys Phe Gly Ser Val Cys Phe Ser Leu Lys Asp Ile 
385                 390                 395                 400 


Pro Gly Gly Cys Ala Met Pro Ile Val Ala Asn Trp Ala Tyr Ser Lys 
                405                 410                 415     


Tyr Tyr Thr Ile Gly Ser Leu Tyr Val Ser Trp Ser Asp Gly Asp Gly 
            420                 425                 430         


Ile Thr Gly Val Pro Gln Pro Val Glu Gly Val Ser Ser Phe Met Asn 
        435                 440                 445             


Val Thr Leu Asp Lys Cys Thr Lys Tyr Asn Ile Tyr Asp Val Ser Gly 
    450                 455                 460                 


Val Gly Val Ile Arg Val Ser Asn Asp Thr Phe Leu Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Thr Ser Thr Ser Gly Asn Leu Leu Gly Phe Lys Asp Val Thr Lys 
                485                 490                 495     


Gly Thr Ile Tyr Ser Ile Thr Pro Cys Asn Pro Pro Asp Gln Leu Val 
            500                 505                 510         


Val Tyr Gln Gln Ala Val Val Gly Ala Met Leu Ser Glu Asn Phe Thr 
        515                 520                 525             


Ser Tyr Gly Phe Ser Asn Val Val Glu Leu Pro Lys Phe Phe Tyr Ala 
    530                 535                 540                 


Ser Asn Gly Thr Tyr Asn Cys Thr Asp Ala Val Leu Thr Tyr Ser Ser 
545                 550                 555                 560 


Phe Gly Val Cys Ala Asp Gly Ser Ile Ile Ala Val Gln Pro Ala Asn 
                565                 570                 575     


Val Ser Tyr Asp Ser Val Ser Ala Ile Val Thr Ala Asn Leu Ser Ile 
            580                 585                 590         


Pro Ser Asn Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr 
        595                 600                 605             


Ser Thr Pro Ile Val Val Asp Cys Ser Thr Tyr Val Cys Asn Gly Asn 
    610                 615                 620                 


Val Arg Cys Val Glu Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr 
625                 630                 635                 640 


Ile Glu Asp Ala Leu Arg Asn Ser Ala Arg Leu Glu Ser Ala Asp Val 
                645                 650                 655     


Ser Glu Met Leu Thr Phe Asp Lys Lys Ala Phe Thr Leu Ala Asn Val 
            660                 665                 670         


Ser Ser Phe Gly Asp Tyr Asn Leu Ser Ser Val Ile Pro Ser Leu Pro 
        675                 680                 685             


Thr Ser Gly Ser Arg Val Ala Gly Arg Ser Ala Ile Glu Asp Ile Leu 
    690                 695                 700                 


Phe Ser Lys Leu Val Thr Ser Gly Leu Gly Thr Val Asp Ala Asp Tyr 
705                 710                 715                 720 


Lys Lys Cys Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln 
                725                 730                 735     


Tyr Tyr Asn Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg 
            740                 745                 750         


Met Ala Met Tyr Thr Gly Ser Leu Ile Gly Gly Ile Ala Leu Gly Gly 
        755                 760                 765             


Leu Thr Ser Ala Val Ser Ile Pro Phe Ser Leu Ala Ile Gln Ala Arg 
    770                 775                 780                 


Leu Asn Tyr Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys 
785                 790                 795                 800 


Ile Leu Ala Ala Ser Phe Asn Lys Ala Met Thr Asn Ile Val Asp Ala 
                805                 810                 815     


Phe Thr Gly Val Asn Asp Ala Ile Thr Gln Thr Ser Gln Ala Leu Gln 
            820                 825                 830         


Thr Val Ala Thr Ala Leu Asn Lys Ile Gln Asp Val Val Asn Gln Gln 
        835                 840                 845             


Gly Asn Ser Leu Asn His Leu Thr Ser Gln Leu Arg Gln Asn Phe Gln 
    850                 855                 860                 


Ala Ile Ser Ser Ser Ile Gln Ala Ile Tyr Asp Arg Leu Asp Pro Pro 
865                 870                 875                 880 


Gln Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ala Ala 
                885                 890                 895     


Leu Asn Val Phe Val Ser His Thr Leu Thr Lys Tyr Thr Glu Val Arg 
            900                 905                 910         


Ala Ser Arg Gln Leu Ala Gln Gln Lys Val Asn Glu Cys Val Lys Ser 
        915                 920                 925             


Gln Ser Lys Arg Tyr Gly Phe Cys Gly Asn Gly Thr His Ile Phe Ser 
    930                 935                 940                 


Ile Val Asn Ala Ala Pro Glu Gly Leu Val Phe Leu His Thr Val Leu 
945                 950                 955                 960 


Leu Pro Thr Gln Tyr Lys Asp Val Glu Ala Trp Ser Gly Leu Cys Val 
                965                 970                 975     


Asp Gly Thr Asn Gly Tyr Val Leu Arg Gln Pro Asn Leu Ala Leu Tyr 
            980                 985                 990         


Lys Glu Gly Asn Tyr Tyr Arg Ile  Thr Ser Arg Ile Met  Phe Glu Pro 
        995                 1000                 1005             


Arg Ile  Pro Thr Met Ala Asp  Phe Val Gln Ile Glu  Asn Cys Asn 
    1010                 1015                 1020             


Val Thr  Phe Val Asn Ile Ser  Arg Ser Glu Leu Gln  Thr Ile Val 
    1025                 1030                 1035             


Pro Glu  Tyr Ile Asp Val Asn  Lys Thr Leu Gln Glu  Leu Ser Tyr 
    1040                 1045                 1050             


Lys Leu  Pro Asn Tyr Thr Val  Pro Asp Leu Val Val  Glu Gln Tyr 
    1055                 1060                 1065             


Asn Gln  Thr Ile Leu Asn Leu  Thr Ser Glu Ile Ser  Thr Leu Glu 
    1070                 1075                 1080             


Asn Lys  Ser Ala Glu Leu Asn  Tyr Thr Val Gln Lys  Leu Gln Thr 
    1085                 1090                 1095             


Leu Ile  Asp Asn Ile Asn Ser  Thr Leu Val Asp Leu  Lys Trp Leu 
    1100                 1105                 1110             


Asn Arg  Val Glu Thr Tyr Ile  Lys Trp Pro Trp Trp  Val Trp Leu 
    1115                 1120                 1125             


Cys Ile  Ser Val Val Leu Ile  Phe Val Val Ser Met  Leu Leu Leu 
    1130                 1135                 1140             


Ser Phe  Trp Met Cys Ser Asn  Gly Ser Leu Gln Cys  Arg Ile Cys 
    1145                 1150                 1155             


Ile 
    


<210>  158
<211>  1360
<212>  PRT
<213>  OC43-Coronavirus

<400>  158

Met Phe Leu Ile Leu Leu Ile Ser Leu Pro Thr Ala Phe Ala Val Ile 
1               5                   10                  15      


Gly Asp Leu Asn Cys Thr Leu Asp Pro Arg Leu Lys Gly Ser Phe Asn 
            20                  25                  30          


Asn Arg Asp Thr Gly Pro Pro Ser Ile Ser Ile Asp Thr Val Asp Val 
        35                  40                  45              


Thr Asn Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn 
    50                  55                  60                  


Thr Thr Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Asn Met Ala Leu Lys Gly Thr Asp Leu Leu Ser Thr Leu Trp Phe 
                85                  90                  95      


Lys Pro Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val 
            100                 105                 110         


Lys Asn Thr Lys Val Phe Lys Asp Gly Val Met Tyr Ser Glu Phe Pro 
        115                 120                 125             


Ala Ile Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val 
    130                 135                 140                 


Val Gln Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Val Asn Lys Leu 
145                 150                 155                 160 


Gln Gly Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr 
                165                 170                 175     


Pro His Thr Ile Cys His Pro Asn Leu Gly Asn His Phe Lys Glu Leu 
            180                 185                 190         


Trp His Tyr Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe 
        195                 200                 205             


Thr Tyr Asp Val Asn Ala Thr Tyr Leu Tyr Phe His Phe Tyr Gln Glu 
    210                 215                 220                 


Gly Gly Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Phe Val Thr Lys 
225                 230                 235                 240 


Phe Leu Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val 
                245                 250                 255     


Met Pro Leu Thr Cys Ile Arg Arg Pro Lys Asp Gly Phe Ser Leu Glu 
            260                 265                 270         


Tyr Trp Val Thr Pro Leu Thr Pro Arg Gln Tyr Leu Leu Ala Phe Asn 
        275                 280                 285             


Gln Asp Gly Ile Ile Phe Asn Ala Val Asp Cys Met Ser Asp Phe Met 
    290                 295                 300                 


Ser Glu Ile Lys Cys Lys Thr Gln Ser Ile Ala Pro Pro Thr Gly Val 
305                 310                 315                 320 


Tyr Glu Leu Asn Gly Tyr Thr Val Gln Pro Val Ala Asp Val Tyr Arg 
                325                 330                 335     


Arg Lys Pro Asp Leu Pro Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp 
            340                 345                 350         


Lys Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn 
        355                 360                 365             


Cys Asn Phe Asn Met Ser Ser Leu Met Ser Phe Ile Gln Ala Asp Ser 
    370                 375                 380                 


Phe Thr Cys Asn Asn Ile Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe 
385                 390                 395                 400 


Ser Ser Ile Thr Ile Asp Lys Phe Ala Ile Pro Asn Arg Arg Lys Val 
                405                 410                 415     


Asp Leu Gln Leu Gly Asn Leu Gly Tyr Leu Gln Ser Ser Asn Tyr Arg 
            420                 425                 430         


Ile Asp Thr Thr Ala Thr Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala 
        435                 440                 445             


Ala Asn Val Ser Val Ser Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg 
    450                 455                 460                 


Phe Gly Phe Ile Glu Asp Ser Val Phe Val Pro Gln Pro Thr Gly Val 
465                 470                 475                 480 


Phe Thr Asn His Ser Val Val Tyr Ala Gln His Cys Phe Lys Ala Pro 
                485                 490                 495     


Lys Asn Phe Cys Pro Cys Ser Ser Cys Ser Cys Pro Gly Lys Asn Asn 
            500                 505                 510         


Gly Ile Gly Thr Cys Pro Ala Gly Thr Asn Ser Leu Thr Cys Asp Asn 
        515                 520                 525             


Leu Cys Thr Leu Asp Pro Ile Thr Leu Lys Ala Pro Asp Thr Tyr Lys 
    530                 535                 540                 


Cys Pro Gln Ser Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly 
545                 550                 555                 560 


Leu Ala Val Lys Ser Asp Tyr Cys Gly Asn Asn Ser Cys Thr Cys Gln 
                565                 570                 575     


Pro Gln Ala Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp 
            580                 585                 590         


Lys Cys Asn Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Asn Gly 
        595                 600                 605             


Leu Thr Cys Ser Thr Asp Leu Gln Lys Ala Asn Thr Glu Ile Glu Leu 
    610                 615                 620                 


Gly Val Cys Val Asn Tyr Asp Leu Tyr Gly Ile Ser Gly Gln Gly Ile 
625                 630                 635                 640 


Phe Val Glu Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu 
                645                 650                 655     


Tyr Asp Ser Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn 
            660                 665                 670         


Arg Thr Phe Met Ile His Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala 
        675                 680                 685             


Tyr His Ala Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys 
    690                 695                 700                 


Cys Asn Tyr Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile 
705                 710                 715                 720 


Asn Tyr Ser Phe Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn 
                725                 730                 735     


Ser Thr Ala Ile Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly 
            740                 745                 750         


Tyr Cys Val Asp Tyr Ser Lys Asn Arg Arg Ser Arg Arg Ala Ile Thr 
        755                 760                 765             


Thr Gly Tyr Arg Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val 
    770                 775                 780                 


Asn Asp Ser Leu Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro 
785                 790                 795                 800 


Ser Glu Phe Thr Ile Gly Asn Met Glu Glu Phe Ile Gln Thr Ser Ser 
                805                 810                 815     


Pro Lys Val Thr Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala 
            820                 825                 830         


Ala Cys Lys Leu Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile 
        835                 840                 845             


Asn Ala Ile Leu Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu 
    850                 855                 860                 


Gln Val Ala Asn Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu 
865                 870                 875                 880 


Lys Asp Gly Val Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val 
                885                 890                 895     


Leu Gly Cys Leu Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala 
            900                 905                 910         


Ile Glu Asp Leu Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe 
        915                 920                 925             


Val Glu Ala Tyr Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu 
    930                 935                 940                 


Ile Cys Val Gln Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu 
945                 950                 955                 960 


Ser Glu Asn Gln Ile Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser 
                965                 970                 975     


Leu Phe Pro Pro Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn 
            980                 985                 990         


Val Gln Tyr Arg Ile Asn Gly Leu  Gly Val Thr Met Asp  Val Leu Ser 
        995                 1000                 1005             


Gln Asn  Gln Lys Leu Ile Ala  Asn Ala Phe Asn Asn  Ala Leu His 
    1010                 1015                 1020             


Ala Ile  Gln Gln Gly Phe Asp  Ala Thr Asn Ser Ala  Leu Val Lys 
    1025                 1030                 1035             


Ile Gln  Ala Val Val Asn Ala  Asn Ala Glu Ala Leu  Asn Asn Leu 
    1040                 1045                 1050             


Leu Gln  Gln Leu Ser Asn Arg  Phe Gly Ala Ile Ser  Ala Ser Leu 
    1055                 1060                 1065             


Gln Glu  Ile Leu Ser Arg Leu  Asp Ala Leu Glu Ala  Glu Ala Gln 
    1070                 1075                 1080             


Ile Asp  Arg Leu Ile Asn Gly  Arg Leu Thr Ala Leu  Asn Ala Tyr 
    1085                 1090                 1095             


Val Ser  Gln Gln Leu Ser Asp  Ser Thr Leu Val Lys  Phe Ser Ala 
    1100                 1105                 1110             


Ala Gln  Ala Met Glu Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser 
    1115                 1120                 1125             


Ser Arg  Ile Asn Phe Cys Gly  Asn Gly Asn His Ile  Ile Ser Leu 
    1130                 1135                 1140             


Val Gln  Asn Ala Pro Tyr Gly  Leu Tyr Phe Ile His  Phe Asn Tyr 
    1145                 1150                 1155             


Val Pro  Thr Lys Tyr Val Thr  Ala Lys Val Ser Pro  Gly Leu Cys 
    1160                 1165                 1170             


Ile Ala  Gly Asn Arg Gly Ile  Ala Pro Lys Ser Gly  Tyr Phe Val 
    1175                 1180                 1185             


Asn Val  Asn Asn Thr Trp Met  Tyr Thr Gly Ser Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Pro Glu  Pro Ile Thr Glu Asn  Asn Val Val Val Met  Ser Thr Cys 
    1205                 1210                 1215             


Ala Val  Asn Tyr Thr Lys Ala  Pro Tyr Val Met Leu  Asn Thr Ser 
    1220                 1225                 1230             


Ile Pro  Asn Leu Pro Asp Phe  Lys Glu Glu Leu Asp  Gln Trp Phe 
    1235                 1240                 1245             


Lys Asn  Gln Thr Ser Val Ala  Pro Asp Leu Ser Leu  Asp Tyr Ile 
    1250                 1255                 1260             


Asn Val  Thr Phe Leu Asp Leu  Gln Val Glu Met Asn  Arg Leu Gln 
    1265                 1270                 1275             


Glu Ala  Ile Lys Val Leu Asn  His Ser Tyr Ile Asn  Leu Lys Asp 
    1280                 1285                 1290             


Ile Gly  Thr Tyr Glu Tyr Tyr  Val Lys Trp Pro Trp  Tyr Val Trp 
    1295                 1300                 1305             


Leu Leu  Ile Cys Leu Ala Gly  Val Ala Met Leu Val  Leu Leu Phe 
    1310                 1315                 1320             


Phe Ile  Cys Cys Cys Thr Gly  Cys Gly Thr Ser Cys  Phe Lys Lys 
    1325                 1330                 1335             


Cys Gly  Gly Cys Cys Asp Asp  Tyr Thr Gly Tyr Gln  Glu Leu Val 
    1340                 1345                 1350             


Ile Lys  Thr Ser His Asp Asp  
    1355                 1360 


<210>  159
<211>  1173
<212>  PRT
<213>  229E Coronavirus

<400>  159

Met Phe Val Leu Leu Val Ala Tyr Ala Leu Leu His Ile Ala Gly Cys 
1               5                   10                  15      


Gln Thr Thr Asn Gly Leu Asn Thr Ser Tyr Ser Val Cys Asn Gly Cys 
            20                  25                  30          


Val Gly Tyr Ser Glu Asn Val Phe Ala Val Glu Ser Gly Gly Tyr Ile 
        35                  40                  45              


Pro Ser Asp Phe Ala Phe Asn Asn Trp Phe Leu Leu Thr Asn Thr Ser 
    50                  55                  60                  


Ser Val Val Asp Gly Val Val Arg Ser Phe Gln Pro Leu Leu Leu Asn 
65                  70                  75                  80  


Cys Leu Trp Ser Val Ser Gly Leu Arg Phe Thr Thr Gly Phe Val Tyr 
                85                  90                  95      


Phe Asn Gly Thr Gly Arg Gly Asp Cys Lys Gly Phe Ser Ser Asp Val 
            100                 105                 110         


Leu Ser Asp Val Ile Arg Tyr Asn Leu Asn Phe Glu Glu Asn Leu Arg 
        115                 120                 125             


Arg Gly Thr Ile Leu Phe Lys Thr Ser Tyr Gly Val Val Val Phe Tyr 
    130                 135                 140                 


Cys Thr Asn Asn Thr Leu Val Ser Gly Asp Ala His Ile Pro Phe Gly 
145                 150                 155                 160 


Thr Val Leu Gly Asn Phe Tyr Cys Phe Val Asn Thr Thr Ile Gly Asn 
                165                 170                 175     


Glu Thr Thr Ser Ala Phe Val Gly Ala Leu Pro Lys Thr Val Arg Glu 
            180                 185                 190         


Phe Val Ile Ser Arg Thr Gly His Phe Tyr Ile Asn Gly Tyr Arg Tyr 
        195                 200                 205             


Phe Thr Leu Gly Asn Val Glu Ala Val Asn Phe Asn Val Thr Thr Ala 
    210                 215                 220                 


Glu Thr Thr Asp Phe Cys Thr Val Ala Leu Ala Ser Tyr Ala Asp Val 
225                 230                 235                 240 


Leu Val Asn Val Ser Gln Thr Ser Ile Ala Asn Ile Ile Tyr Cys Asn 
                245                 250                 255     


Ser Val Ile Asn Arg Leu Arg Cys Asp Gln Leu Ser Phe Asp Val Pro 
            260                 265                 270         


Asp Gly Phe Tyr Ser Thr Ser Pro Ile Gln Ser Val Glu Leu Pro Val 
        275                 280                 285             


Ser Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile Val Leu 
    290                 295                 300                 


Tyr Val Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys Phe Asn Cys 
305                 310                 315                 320 


Tyr Pro Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn Glu Thr Lys 
                325                 330                 335     


Gly Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys Tyr Val Ala 
            340                 345                 350         


Val Tyr Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn Thr Gly Asn 
        355                 360                 365             


Cys Pro Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys Phe Gly Ser 
    370                 375                 380                 


Val Cys Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala Met Pro Ile 
385                 390                 395                 400 


Val Ala Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly Ser Leu Tyr 
                405                 410                 415     


Val Ser Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro Gln Pro Val 
            420                 425                 430         


Glu Gly Val Ser Ser Phe Met Asn Val Thr Leu Asp Lys Cys Thr Lys 
        435                 440                 445             


Tyr Asn Ile Tyr Asp Val Ser Gly Val Gly Val Ile Arg Val Ser Asn 
    450                 455                 460                 


Asp Thr Phe Leu Asn Gly Ile Thr Tyr Thr Ser Thr Ser Gly Asn Leu 
465                 470                 475                 480 


Leu Gly Phe Lys Asp Val Thr Lys Gly Thr Ile Tyr Ser Ile Thr Pro 
                485                 490                 495     


Cys Asn Pro Pro Asp Gln Leu Val Val Tyr Gln Gln Ala Val Val Gly 
            500                 505                 510         


Ala Met Leu Ser Glu Asn Phe Thr Ser Tyr Gly Phe Ser Asn Val Val 
        515                 520                 525             


Glu Leu Pro Lys Phe Phe Tyr Ala Ser Asn Gly Thr Tyr Asn Cys Thr 
    530                 535                 540                 


Asp Ala Val Leu Thr Tyr Ser Ser Phe Gly Val Cys Ala Asp Gly Ser 
545                 550                 555                 560 


Ile Ile Ala Val Gln Pro Arg Asn Val Ser Tyr Asp Ser Val Ser Ala 
                565                 570                 575     


Ile Val Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp Thr Thr Ser Val 
            580                 585                 590         


Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile Val Val Asp Cys 
        595                 600                 605             


Ser Thr Tyr Val Cys Asn Gly Asn Val Arg Cys Val Glu Leu Leu Lys 
    610                 615                 620                 


Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala Leu Arg Asn Ser 
625                 630                 635                 640 


Ala Arg Leu Glu Ser Ala Asp Val Ser Glu Met Leu Thr Phe Asp Lys 
                645                 650                 655     


Lys Ala Phe Thr Leu Ala Asn Val Ser Ser Phe Gly Asp Tyr Asn Leu 
            660                 665                 670         


Ser Ser Val Ile Pro Ser Leu Pro Thr Ser Gly Ser Arg Val Ala Gly 
        675                 680                 685             


Arg Ser Ala Ile Glu Asp Ile Leu Phe Ser Lys Leu Val Thr Ser Gly 
    690                 695                 700                 


Leu Gly Thr Val Asp Ala Asp Tyr Lys Lys Cys Thr Lys Gly Leu Ser 
705                 710                 715                 720 


Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val Leu 
                725                 730                 735     


Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr Thr Gly Ser Leu 
            740                 745                 750         


Ile Gly Gly Ile Ala Leu Gly Gly Leu Thr Ser Ala Val Ser Ile Pro 
        755                 760                 765             


Phe Ser Leu Ala Ile Gln Ala Arg Leu Asn Tyr Val Ala Leu Gln Thr 
    770                 775                 780                 


Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala Ser Phe Asn Lys 
785                 790                 795                 800 


Ala Met Thr Asn Ile Val Asp Ala Phe Thr Gly Val Asn Asp Ala Ile 
                805                 810                 815     


Thr Gln Thr Ser Gln Ala Leu Gln Thr Val Ala Thr Ala Leu Asn Lys 
            820                 825                 830         


Ile Gln Asp Val Val Asn Gln Gln Gly Asn Ser Leu Asn His Leu Thr 
        835                 840                 845             


Ser Gln Leu Arg Gln Asn Phe Gln Ala Ile Ser Ser Ser Ile Gln Ala 
    850                 855                 860                 


Ile Tyr Asp Arg Leu Asp Thr Ile Gln Ala Asp Gln Gln Val Asp Arg 
865                 870                 875                 880 


Leu Ile Thr Gly Arg Leu Ala Ala Leu Asn Val Phe Val Ser His Thr 
                885                 890                 895     


Leu Thr Lys Tyr Thr Glu Val Arg Ala Ser Arg Gln Leu Ala Gln Gln 
            900                 905                 910         


Lys Val Asn Glu Cys Val Lys Ser Gln Ser Lys Arg Tyr Gly Phe Cys 
        915                 920                 925             


Gly Asn Gly Thr His Ile Phe Ser Ile Val Asn Ala Ala Pro Glu Gly 
    930                 935                 940                 


Leu Val Phe Leu His Thr Val Leu Leu Pro Thr Gln Tyr Lys Asp Val 
945                 950                 955                 960 


Glu Ala Trp Ser Gly Leu Cys Val Asp Gly Thr Asn Gly Tyr Val Leu 
                965                 970                 975     


Arg Gln Pro Asn Leu Ala Leu Tyr Lys Glu Gly Asn Tyr Tyr Arg Ile 
            980                 985                 990         


Thr Ser Arg Ile Met Phe Glu Pro  Arg Ile Pro Thr Met  Ala Asp Phe 
        995                 1000                 1005             


Val Gln  Ile Glu Asn Cys Asn  Val Thr Phe Val Asn  Ile Ser Arg 
    1010                 1015                 1020             


Ser Glu  Leu Gln Thr Ile Val  Pro Glu Tyr Ile Asp  Val Asn Lys 
    1025                 1030                 1035             


Thr Leu  Gln Glu Leu Ser Tyr  Lys Leu Pro Asn Tyr  Thr Val Pro 
    1040                 1045                 1050             


Asp Leu  Val Val Glu Gln Tyr  Asn Gln Thr Ile Leu  Asn Leu Thr 
    1055                 1060                 1065             


Ser Glu  Ile Ser Thr Leu Glu  Asn Lys Ser Ala Glu  Leu Asn Tyr 
    1070                 1075                 1080             


Thr Val  Gln Lys Leu Gln Thr  Leu Ile Asp Asn Ile  Asn Ser Thr 
    1085                 1090                 1095             


Leu Val  Asp Leu Lys Trp Leu  Asn Arg Val Glu Thr  Tyr Ile Lys 
    1100                 1105                 1110             


Trp Pro  Trp Trp Val Trp Leu  Cys Ile Ser Val Val  Leu Ile Phe 
    1115                 1120                 1125             


Val Val  Ser Met Leu Leu Leu  Cys Cys Cys Ser Thr  Gly Cys Cys 
    1130                 1135                 1140             


Gly Phe  Phe Ser Cys Phe Ala  Ser Ser Ile Arg Gly  Cys Cys Glu 
    1145                 1150                 1155             


Ser Thr  Lys Leu Pro Tyr Tyr  Asp Val Glu Lys Ile  His Ile Gln 
    1160                 1165                 1170             


<210>  160
<211>  1346
<212>  PRT
<213>  OC43 Coronavirus

<400>  160

Val Ile Gly Asp Leu Asn Cys Thr Leu Asp Pro Arg Leu Lys Gly Ser 
1               5                   10                  15      


Phe Asn Asn Arg Asp Thr Gly Pro Pro Ser Ile Ser Ile Asp Thr Val 
            20                  25                  30          


Asp Val Thr Asn Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr 
        35                  40                  45              


Leu Asn Thr Thr Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser 
    50                  55                  60                  


Thr Tyr Arg Asn Met Ala Leu Lys Gly Thr Asp Leu Leu Ser Thr Leu 
65                  70                  75                  80  


Trp Phe Lys Pro Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala 
                85                  90                  95      


Lys Val Lys Asn Thr Lys Val Phe Lys Asp Gly Val Met Tyr Ser Glu 
            100                 105                 110         


Phe Pro Ala Ile Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser 
        115                 120                 125             


Val Val Val Gln Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Val Asn 
    130                 135                 140                 


Lys Leu Gln Gly Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys 
145                 150                 155                 160 


Glu Tyr Pro His Thr Ile Cys His Pro Asn Leu Gly Asn His Phe Lys 
                165                 170                 175     


Glu Leu Trp His Tyr Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg 
            180                 185                 190         


Asn Phe Thr Tyr Asp Val Asn Ala Thr Tyr Leu Tyr Phe His Phe Tyr 
        195                 200                 205             


Gln Glu Gly Gly Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Phe Val 
    210                 215                 220                 


Thr Lys Phe Leu Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr 
225                 230                 235                 240 


Tyr Val Met Pro Leu Thr Cys Ile Arg Arg Pro Lys Asp Gly Phe Ser 
                245                 250                 255     


Leu Glu Tyr Trp Val Thr Pro Leu Thr Pro Arg Gln Tyr Leu Leu Ala 
            260                 265                 270         


Phe Asn Gln Asp Gly Ile Ile Phe Asn Ala Val Asp Cys Met Ser Asp 
        275                 280                 285             


Phe Met Ser Glu Ile Lys Cys Lys Thr Gln Ser Ile Ala Pro Pro Thr 
    290                 295                 300                 


Gly Val Tyr Glu Leu Asn Gly Tyr Thr Val Gln Pro Val Ala Asp Val 
305                 310                 315                 320 


Tyr Arg Arg Lys Pro Asp Leu Pro Asn Cys Asn Ile Glu Ala Trp Leu 
                325                 330                 335     


Asn Asp Lys Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr Phe 
            340                 345                 350         


Ser Asn Cys Asn Phe Asn Met Ser Ser Leu Met Ser Phe Ile Gln Ala 
        355                 360                 365             


Asp Ser Phe Thr Cys Asn Asn Ile Asp Ala Ala Lys Ile Tyr Gly Met 
    370                 375                 380                 


Cys Phe Ser Ser Ile Thr Ile Asp Lys Phe Ala Ile Pro Asn Arg Arg 
385                 390                 395                 400 


Lys Val Asp Leu Gln Leu Gly Asn Leu Gly Tyr Leu Gln Ser Ser Asn 
                405                 410                 415     


Tyr Arg Ile Asp Thr Thr Ala Thr Ser Cys Gln Leu Tyr Tyr Asn Leu 
            420                 425                 430         


Pro Ala Ala Asn Val Ser Val Ser Arg Phe Asn Pro Ser Thr Trp Asn 
        435                 440                 445             


Lys Arg Phe Gly Phe Ile Glu Asp Ser Val Phe Val Pro Gln Pro Thr 
    450                 455                 460                 


Gly Val Phe Thr Asn His Ser Val Val Tyr Ala Gln His Cys Phe Lys 
465                 470                 475                 480 


Ala Pro Lys Asn Phe Cys Pro Cys Ser Ser Cys Ser Cys Pro Gly Lys 
                485                 490                 495     


Asn Asn Gly Ile Gly Thr Cys Pro Ala Gly Thr Asn Ser Leu Thr Cys 
            500                 505                 510         


Asp Asn Leu Cys Thr Leu Asp Pro Ile Thr Leu Lys Ala Pro Asp Thr 
        515                 520                 525             


Tyr Lys Cys Pro Gln Ser Lys Ser Leu Val Gly Ile Gly Glu His Cys 
    530                 535                 540                 


Ser Gly Leu Ala Val Lys Ser Asp Tyr Cys Gly Asn Asn Ser Cys Thr 
545                 550                 555                 560 


Cys Gln Pro Gln Ala Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln 
                565                 570                 575     


Gly Asp Lys Cys Asn Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn 
            580                 585                 590         


Asn Gly Leu Thr Cys Ser Thr Asp Leu Gln Lys Ala Asn Thr Glu Ile 
        595                 600                 605             


Glu Leu Gly Val Cys Val Asn Tyr Asp Leu Tyr Gly Ile Ser Gly Gln 
    610                 615                 620                 


Gly Ile Phe Val Glu Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn 
625                 630                 635                 640 


Leu Leu Tyr Asp Ser Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile 
                645                 650                 655     


Thr Asn Arg Thr Phe Met Ile His Ser Cys Tyr Ser Gly Arg Val Ser 
            660                 665                 670         


Ala Ala Tyr His Ala Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn 
        675                 680                 685             


Ile Lys Cys Asn Tyr Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln 
    690                 695                 700                 


Pro Ile Asn Tyr Ser Phe Asp Ser Tyr Leu Gly Cys Val Val Asn Ala 
705                 710                 715                 720 


Tyr Asn Ser Thr Ala Ile Ser Val Gln Thr Cys Asp Leu Thr Val Gly 
                725                 730                 735     


Ser Gly Tyr Cys Val Asp Tyr Ser Lys Asn Arg Arg Ser Arg Arg Ala 
            740                 745                 750         


Ile Thr Thr Gly Tyr Arg Phe Thr Asn Phe Glu Pro Phe Thr Val Asn 
        755                 760                 765             


Ser Val Asn Asp Ser Leu Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln 
    770                 775                 780                 


Ile Pro Ser Glu Phe Thr Ile Gly Asn Met Glu Glu Phe Ile Gln Thr 
785                 790                 795                 800 


Ser Ser Pro Lys Val Thr Ile Asp Cys Ala Ala Phe Val Cys Gly Asp 
                805                 810                 815     


Tyr Ala Ala Cys Lys Leu Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp 
            820                 825                 830         


Asn Ile Asn Ala Ile Leu Thr Glu Val Asn Glu Leu Leu Asp Thr Thr 
        835                 840                 845             


Gln Leu Gln Val Ala Asn Ser Leu Met Asn Gly Val Thr Leu Ser Thr 
    850                 855                 860                 


Lys Leu Lys Asp Gly Val Asn Phe Asn Val Asp Asp Ile Asn Phe Ser 
865                 870                 875                 880 


Pro Val Leu Gly Cys Leu Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg 
                885                 890                 895     


Ser Ala Ile Glu Asp Leu Leu Phe Asp Lys Val Lys Leu Ser Asp Val 
            900                 905                 910         


Gly Phe Val Glu Ala Tyr Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg 
        915                 920                 925             


Asp Leu Ile Cys Val Gln Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro 
    930                 935                 940                 


Leu Leu Ser Glu Asn Gln Ile Ser Gly Tyr Thr Leu Ala Ala Thr Ser 
945                 950                 955                 960 


Ala Ser Leu Phe Pro Pro Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr 
                965                 970                 975     


Leu Asn Val Gln Tyr Arg Ile Asn Gly Leu Gly Val Thr Met Asp Val 
            980                 985                 990         


Leu Ser Gln Asn Gln Lys Leu Ile  Ala Asn Ala Phe Asn  Asn Ala Leu 
        995                 1000                 1005             


His Ala  Ile Gln Gln Gly Phe  Asp Ala Thr Asn Ser  Ala Leu Val 
    1010                 1015                 1020             


Lys Ile  Gln Ala Val Val Asn  Ala Asn Ala Glu Ala  Leu Asn Asn 
    1025                 1030                 1035             


Leu Leu  Gln Gln Leu Ser Asn  Arg Phe Gly Ala Ile  Ser Ala Ser 
    1040                 1045                 1050             


Leu Gln  Glu Ile Leu Ser Arg  Leu Asp Ala Leu Glu  Ala Glu Ala 
    1055                 1060                 1065             


Gln Ile  Asp Arg Leu Ile Asn  Gly Arg Leu Thr Ala  Leu Asn Ala 
    1070                 1075                 1080             


Tyr Val  Ser Gln Gln Leu Ser  Asp Ser Thr Leu Val  Lys Phe Ser 
    1085                 1090                 1095             


Ala Ala  Gln Ala Met Glu Lys  Val Asn Glu Cys Val  Lys Ser Gln 
    1100                 1105                 1110             


Ser Ser  Arg Ile Asn Phe Cys  Gly Asn Gly Asn His  Ile Ile Ser 
    1115                 1120                 1125             


Leu Val  Gln Asn Ala Pro Tyr  Gly Leu Tyr Phe Ile  His Phe Asn 
    1130                 1135                 1140             


Tyr Val  Pro Thr Lys Tyr Val  Thr Ala Lys Val Ser  Pro Gly Leu 
    1145                 1150                 1155             


Cys Ile  Ala Gly Asn Arg Gly  Ile Ala Pro Lys Ser  Gly Tyr Phe 
    1160                 1165                 1170             


Val Asn  Val Asn Asn Thr Trp  Met Tyr Thr Gly Ser  Gly Tyr Tyr 
    1175                 1180                 1185             


Tyr Pro  Glu Pro Ile Thr Glu  Asn Asn Val Val Val  Met Ser Thr 
    1190                 1195                 1200             


Cys Ala  Val Asn Tyr Thr Lys  Ala Pro Tyr Val Met  Leu Asn Thr 
    1205                 1210                 1215             


Ser Ile  Pro Asn Leu Pro Asp  Phe Lys Glu Glu Leu  Asp Gln Trp 
    1220                 1225                 1230             


Phe Lys  Asn Gln Thr Ser Val  Ala Pro Asp Leu Ser  Leu Asp Tyr 
    1235                 1240                 1245             


Ile Asn  Val Thr Phe Leu Asp  Leu Gln Val Glu Met  Asn Arg Leu 
    1250                 1255                 1260             


Gln Glu  Ala Ile Lys Val Leu  Asn His Ser Tyr Ile  Asn Leu Lys 
    1265                 1270                 1275             


Asp Ile  Gly Thr Tyr Glu Tyr  Tyr Val Lys Trp Pro  Trp Tyr Val 
    1280                 1285                 1290             


Trp Leu  Leu Ile Cys Leu Ala  Gly Val Ala Met Leu  Val Leu Leu 
    1295                 1300                 1305             


Phe Phe  Ile Cys Cys Cys Thr  Gly Cys Gly Thr Ser  Cys Phe Lys 
    1310                 1315                 1320             


Lys Cys  Gly Gly Cys Cys Asp  Asp Tyr Thr Gly Tyr  Gln Glu Leu 
    1325                 1330                 1335             


Val Ile  Lys Thr Ser His Asp  Asp 
    1340                 1345     


<210>  161
<211>  1157
<212>  PRT
<213>  229E Coronavirus

<400>  161

Gln Thr Thr Asn Gly Leu Asn Thr Ser Tyr Ser Val Cys Asn Gly Cys 
1               5                   10                  15      


Val Gly Tyr Ser Glu Asn Val Phe Ala Val Glu Ser Gly Gly Tyr Ile 
            20                  25                  30          


Pro Ser Asp Phe Ala Phe Asn Asn Trp Phe Leu Leu Thr Asn Thr Ser 
        35                  40                  45              


Ser Val Val Asp Gly Val Val Arg Ser Phe Gln Pro Leu Leu Leu Asn 
    50                  55                  60                  


Cys Leu Trp Ser Val Ser Gly Leu Arg Phe Thr Thr Gly Phe Val Tyr 
65                  70                  75                  80  


Phe Asn Gly Thr Gly Arg Gly Asp Cys Lys Gly Phe Ser Ser Asp Val 
                85                  90                  95      


Leu Ser Asp Val Ile Arg Tyr Asn Leu Asn Phe Glu Glu Asn Leu Arg 
            100                 105                 110         


Arg Gly Thr Ile Leu Phe Lys Thr Ser Tyr Gly Val Val Val Phe Tyr 
        115                 120                 125             


Cys Thr Asn Asn Thr Leu Val Ser Gly Asp Ala His Ile Pro Phe Gly 
    130                 135                 140                 


Thr Val Leu Gly Asn Phe Tyr Cys Phe Val Asn Thr Thr Ile Gly Asn 
145                 150                 155                 160 


Glu Thr Thr Ser Ala Phe Val Gly Ala Leu Pro Lys Thr Val Arg Glu 
                165                 170                 175     


Phe Val Ile Ser Arg Thr Gly His Phe Tyr Ile Asn Gly Tyr Arg Tyr 
            180                 185                 190         


Phe Thr Leu Gly Asn Val Glu Ala Val Asn Phe Asn Val Thr Thr Ala 
        195                 200                 205             


Glu Thr Thr Asp Phe Cys Thr Val Ala Leu Ala Ser Tyr Ala Asp Val 
    210                 215                 220                 


Leu Val Asn Val Ser Gln Thr Ser Ile Ala Asn Ile Ile Tyr Cys Asn 
225                 230                 235                 240 


Ser Val Ile Asn Arg Leu Arg Cys Asp Gln Leu Ser Phe Asp Val Pro 
                245                 250                 255     


Asp Gly Phe Tyr Ser Thr Ser Pro Ile Gln Ser Val Glu Leu Pro Val 
            260                 265                 270         


Ser Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile Val Leu 
        275                 280                 285             


Tyr Val Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys Phe Asn Cys 
    290                 295                 300                 


Tyr Pro Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn Glu Thr Lys 
305                 310                 315                 320 


Gly Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys Tyr Val Ala 
                325                 330                 335     


Val Tyr Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn Thr Gly Asn 
            340                 345                 350         


Cys Pro Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys Phe Gly Ser 
        355                 360                 365             


Val Cys Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala Met Pro Ile 
    370                 375                 380                 


Val Ala Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly Ser Leu Tyr 
385                 390                 395                 400 


Val Ser Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro Gln Pro Val 
                405                 410                 415     


Glu Gly Val Ser Ser Phe Met Asn Val Thr Leu Asp Lys Cys Thr Lys 
            420                 425                 430         


Tyr Asn Ile Tyr Asp Val Ser Gly Val Gly Val Ile Arg Val Ser Asn 
        435                 440                 445             


Asp Thr Phe Leu Asn Gly Ile Thr Tyr Thr Ser Thr Ser Gly Asn Leu 
    450                 455                 460                 


Leu Gly Phe Lys Asp Val Thr Lys Gly Thr Ile Tyr Ser Ile Thr Pro 
465                 470                 475                 480 


Cys Asn Pro Pro Asp Gln Leu Val Val Tyr Gln Gln Ala Val Val Gly 
                485                 490                 495     


Ala Met Leu Ser Glu Asn Phe Thr Ser Tyr Gly Phe Ser Asn Val Val 
            500                 505                 510         


Glu Leu Pro Lys Phe Phe Tyr Ala Ser Asn Gly Thr Tyr Asn Cys Thr 
        515                 520                 525             


Asp Ala Val Leu Thr Tyr Ser Ser Phe Gly Val Cys Ala Asp Gly Ser 
    530                 535                 540                 


Ile Ile Ala Val Gln Pro Arg Asn Val Ser Tyr Asp Ser Val Ser Ala 
545                 550                 555                 560 


Ile Val Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp Thr Thr Ser Val 
                565                 570                 575     


Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile Val Val Asp Cys 
            580                 585                 590         


Ser Thr Tyr Val Cys Asn Gly Asn Val Arg Cys Val Glu Leu Leu Lys 
        595                 600                 605             


Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala Leu Arg Asn Ser 
    610                 615                 620                 


Ala Arg Leu Glu Ser Ala Asp Val Ser Glu Met Leu Thr Phe Asp Lys 
625                 630                 635                 640 


Lys Ala Phe Thr Leu Ala Asn Val Ser Ser Phe Gly Asp Tyr Asn Leu 
                645                 650                 655     


Ser Ser Val Ile Pro Ser Leu Pro Thr Ser Gly Ser Arg Val Ala Gly 
            660                 665                 670         


Arg Ser Ala Ile Glu Asp Ile Leu Phe Ser Lys Leu Val Thr Ser Gly 
        675                 680                 685             


Leu Gly Thr Val Asp Ala Asp Tyr Lys Lys Cys Thr Lys Gly Leu Ser 
    690                 695                 700                 


Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val Leu 
705                 710                 715                 720 


Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr Thr Gly Ser Leu 
                725                 730                 735     


Ile Gly Gly Ile Ala Leu Gly Gly Leu Thr Ser Ala Val Ser Ile Pro 
            740                 745                 750         


Phe Ser Leu Ala Ile Gln Ala Arg Leu Asn Tyr Val Ala Leu Gln Thr 
        755                 760                 765             


Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala Ser Phe Asn Lys 
    770                 775                 780                 


Ala Met Thr Asn Ile Val Asp Ala Phe Thr Gly Val Asn Asp Ala Ile 
785                 790                 795                 800 


Thr Gln Thr Ser Gln Ala Leu Gln Thr Val Ala Thr Ala Leu Asn Lys 
                805                 810                 815     


Ile Gln Asp Val Val Asn Gln Gln Gly Asn Ser Leu Asn His Leu Thr 
            820                 825                 830         


Ser Gln Leu Arg Gln Asn Phe Gln Ala Ile Ser Ser Ser Ile Gln Ala 
        835                 840                 845             


Ile Tyr Asp Arg Leu Asp Thr Ile Gln Ala Asp Gln Gln Val Asp Arg 
    850                 855                 860                 


Leu Ile Thr Gly Arg Leu Ala Ala Leu Asn Val Phe Val Ser His Thr 
865                 870                 875                 880 


Leu Thr Lys Tyr Thr Glu Val Arg Ala Ser Arg Gln Leu Ala Gln Gln 
                885                 890                 895     


Lys Val Asn Glu Cys Val Lys Ser Gln Ser Lys Arg Tyr Gly Phe Cys 
            900                 905                 910         


Gly Asn Gly Thr His Ile Phe Ser Ile Val Asn Ala Ala Pro Glu Gly 
        915                 920                 925             


Leu Val Phe Leu His Thr Val Leu Leu Pro Thr Gln Tyr Lys Asp Val 
    930                 935                 940                 


Glu Ala Trp Ser Gly Leu Cys Val Asp Gly Thr Asn Gly Tyr Val Leu 
945                 950                 955                 960 


Arg Gln Pro Asn Leu Ala Leu Tyr Lys Glu Gly Asn Tyr Tyr Arg Ile 
                965                 970                 975     


Thr Ser Arg Ile Met Phe Glu Pro Arg Ile Pro Thr Met Ala Asp Phe 
            980                 985                 990         


Val Gln Ile Glu Asn Cys Asn Val  Thr Phe Val Asn Ile  Ser Arg Ser 
        995                 1000                 1005             


Glu Leu  Gln Thr Ile Val Pro  Glu Tyr Ile Asp Val  Asn Lys Thr 
    1010                 1015                 1020             


Leu Gln  Glu Leu Ser Tyr Lys  Leu Pro Asn Tyr Thr  Val Pro Asp 
    1025                 1030                 1035             


Leu Val  Val Glu Gln Tyr Asn  Gln Thr Ile Leu Asn  Leu Thr Ser 
    1040                 1045                 1050             


Glu Ile  Ser Thr Leu Glu Asn  Lys Ser Ala Glu Leu  Asn Tyr Thr 
    1055                 1060                 1065             


Val Gln  Lys Leu Gln Thr Leu  Ile Asp Asn Ile Asn  Ser Thr Leu 
    1070                 1075                 1080             


Val Asp  Leu Lys Trp Leu Asn  Arg Val Glu Thr Tyr  Ile Lys Trp 
    1085                 1090                 1095             


Pro Trp  Trp Val Trp Leu Cys  Ile Ser Val Val Leu  Ile Phe Val 
    1100                 1105                 1110             


Val Ser  Met Leu Leu Leu Cys  Cys Cys Ser Thr Gly  Cys Cys Gly 
    1115                 1120                 1125             


Phe Phe  Ser Cys Phe Ala Ser  Ser Ile Arg Gly Cys  Cys Glu Ser 
    1130                 1135                 1140             


Thr Lys  Leu Pro Tyr Tyr Asp  Val Glu Lys Ile His  Ile Gln 
    1145                 1150                 1155         


<210>  162
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-OC43-COV wtTMCT-AA

<400>  162

Trp Tyr Val Trp Leu Leu Ile Cys Leu Ala Gly Val Ala Met Leu Val 
1               5                   10                  15      


Leu Leu Phe Phe Ile Cys Cys Cys Thr Gly Cys Gly Thr Ser Cys Phe 
            20                  25                  30          


Lys Lys Cys Gly Gly Cys Cys Asp Asp Tyr Thr Gly Tyr Gln Glu Leu 
        35                  40                  45              


Val Ile Lys Thr Ser His Asp Asp 
    50                  55      


<210>  163
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-OC43-COV H5iTMCT-AA

<400>  163

Trp Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
1               5                   10                  15      


Leu Ala Ile Met Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
            20                  25                  30          


Ser Leu Gln Cys Arg Ile Cys Ile 
        35                  40  


<210>  164
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-OC43-COV H5iCT-AA

<400>  164

Trp Tyr Val Trp Leu Leu Ile Cys Leu Ala Gly Val Ala Met Leu Val 
1               5                   10                  15      


Leu Leu Phe Phe Ile Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln 
            20                  25                  30          


Cys Arg Ile Cys Ile 
        35          


<210>  165
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-OC43-COV H5iCT(V4)-AA

<400>  165

Trp Tyr Val Trp Leu Leu Ile Cys Leu Ala Gly Val Ala Met Leu Val 
1               5                   10                  15      


Leu Leu Phe Phe Ile Cys Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
            20                  25                  30          


Cys Ile 
        


<210>  166
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-OC43-COV H1cCT-AA

<400>  166

Trp Tyr Val Trp Leu Leu Ile Cys Leu Ala Gly Val Ala Met Leu Val 
1               5                   10                  15      


Leu Leu Phe Phe Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
            20                  25                  30          


Cys Arg Ile Cys Ile 
        35          


<210>  167
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-229E-wtTMCT-AA

<400>  167

Trp Trp Val Trp Leu Cys Ile Ser Val Val Leu Ile Phe Val Val Ser 
1               5                   10                  15      


Met Leu Leu Leu Cys Cys Cys Ser Thr Gly Cys Cys Gly Phe Phe Ser 
            20                  25                  30          


Cys Phe Ala Ser Ser Ile Arg Gly Cys Cys Glu Ser Thr Lys Leu Pro 
        35                  40                  45              


Tyr Tyr Asp Val Glu Lys Ile His Ile Gln 
    50                  55              


<210>  168
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-229E-H5iTMCT-AA

<400>  168

Trp Trp Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
1               5                   10                  15      


Leu Ala Ile Met Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
            20                  25                  30          


Ser Leu Gln Cys Arg Ile Cys Ile 
        35                  40  


<210>  169
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-229E-H5iCT-AA

<400>  169

Trp Trp Val Trp Leu Cys Ile Ser Val Val Leu Ile Phe Val Val Ser 
1               5                   10                  15      


Met Leu Leu Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
            20                  25                  30          


Arg Ile Cys Ile 
        35      


<210>  170
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-229E-H5iCT(V4)-AA

<400>  170

Trp Trp Val Trp Leu Cys Ile Ser Val Val Leu Ile Phe Val Val Ser 
1               5                   10                  15      


Met Leu Leu Leu Cys Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys 
            20                  25                  30          


Ile 
    


<210>  171
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMCT region of modified PDI-229E-H1cCT-AA

<400>  171

Trp Val Trp Leu Cys Ile Ser Val Val Leu Ile Phe Val Val Ser Met 
1               5                   10                  15      


Leu Leu Leu Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg 
            20                  25                  30          


Ile Cys Ile 
        35  


<210>  172
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM/CT Region of Modified OC43-CoV S protein with intervening 
       peptide sequence Xn


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa may be any combination of 0 to 10 amino acids

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  172

Trp Tyr Val Trp Leu Leu Ile Cys Leu Ala Gly Val Ala Met Leu Val 
1               5                   10                  15      


Leu Leu Phe Phe Ile Xaa Cys Ser Asn Gly Ser Xaa Xaa Cys Xaa Ile 
            20                  25                  30          


Cys Ile 
        


<210>  173
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM/CT Region of Modified OC43-CoV S protein with intervening 
       peptide sequence Xn


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa may be any combination of 0 to 10 amino acids

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  173

Trp Trp Val Trp Leu Cys Ile Ser Val Val Leu Ile Phe Val Val Ser 
1               5                   10                  15      


Met Leu Leu Leu Xaa Cys Ser Asn Gly Ser Xaa Xaa Cys Xaa Ile Cys 
            20                  25                  30          


Ile 
    


