                              sequence LISTING

<110> TRUSTEES OF BOSTON UNIVERSITY
 
<120> NOVEL DRUG-CONTROLLED SYSTEMS AND USES THEREOF

<130> 701586-098320WOPT

<140> PCT/US2021/048338
<141> 2021-08-31

<150> 63/072,695
<151> 2020-08-31

<160> 193   

<170> PatentIn version 3.5

<210> 1
<211> 233
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210> 2
<211> 170
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Asp Thr Phe 
        115                 120                 125             


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
    130                 135                 140                 


Glu Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val 
145                 150                 155                 160 


Val Leu Leu Gly Ser Leu Phe Ser Arg Lys 
                165                 170 


<210> 3
<211> 168
<212> PRT
<213> Homo sapiens

<400> 3
Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 
    50                  55                  60                  


Gly Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr 
65                  70                  75                  80  


Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg 
                85                  90                  95      


Ser Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg 
            100                 105                 110         


Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly 
        115                 120                 125             


Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser 
    130                 135                 140                 


Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Pro Ser Gln 
                165             


<210> 4
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Gly Glu Leu Asp Glu Leu Val Tyr Leu Leu Asp Gly Pro Gly Tyr Asp 
1               5                   10                  15      


Pro Ile His Cys Asp Val Val Thr Arg Gly Gly Ser His Leu Phe Asn 
            20                  25                  30          


Phe 
    


<210> 5
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Glu Leu Asp Glu Leu Val Tyr Leu Leu Asp Gly Pro Gly Tyr Asp 
1               5                   10                  15      


Pro Ile His Ser 
            20  


<210> 6
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Ala Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210> 7
<211> 225
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Ala Ser Ser Glu Asp Val Ile Lys Glu Phe Met Arg Phe Lys Val 
1               5                   10                  15      


Arg Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 
            20                  25                  30          


Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val 
        35                  40                  45              


Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 
    50                  55                  60                  


Phe Gln Tyr Gly Ser Lys Val Tyr Val Lys His Pro Ala Asp Ile Pro 
65                  70                  75                  80  


Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val 
                85                  90                  95      


Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser 
            100                 105                 110         


Leu Gln Asp Gly Ser Phe Ile Tyr Lys Val Lys Phe Ile Gly Val Asn 
        115                 120                 125             


Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu 
    130                 135                 140                 


Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu 
145                 150                 155                 160 


Ile His Lys Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val Glu 
                165                 170                 175     


Phe Lys Ser Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr 
            180                 185                 190         


Tyr Tyr Val Asp Ser Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr 
        195                 200                 205             


Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His His Leu Phe 
    210                 215                 220                 


Leu 
225 


<210> 8
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Ser Arg Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
1               5                   10                  15      


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
            20                  25                  30          


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
        35                  40                  45              


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
    50                  55                  60                  


Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
65                  70                  75                  80  


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
                85                  90                  95      


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
            100                 105                 110         


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
        115                 120                 125             


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
    130                 135                 140                 


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
145                 150                 155                 160 


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
                165                 170                 175     


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
            180                 185                 190         


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
        195                 200                 205             


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
    210                 215                 220                 


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
225                 230                 235                 240 


Lys 
    


<210> 9
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Lys Thr Asn Leu Phe Leu Phe Leu Ile Phe Ser Leu Leu Leu Ser 
1               5                   10                  15      


Leu Ser Ser Ala Glu Phe Gly Ala Val Ser Lys Gly Glu Glu Leu Phe 
            20                  25                  30          


Gly Gly Ile Val Pro Ile Leu Val Glu Leu Glu Gly Asp Val Asn Gly 
        35                  40                  45              


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    50                  55                  60                  


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
65                  70                  75                  80  


Trp Pro Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser 
                85                  90                  95      


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Val Met 
            100                 105                 110         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        115                 120                 125             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    130                 135                 140                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
145                 150                 155                 160 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile 
                165                 170                 175     


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ala Arg 
            180                 185                 190         


His Asn Ile Thr Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        195                 200                 205             


Asn Thr Pro Ile Gly Asp Gly Pro Val Ile Leu Pro Asp Asn His Tyr 
    210                 215                 220                 


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
225                 230                 235                 240 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly 
                245                 250                 255     


Met Asp Glu Leu Tyr Lys His Asp Glu Leu 
            260                 265     


<210> 10
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Ala Ile Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 11
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Leu His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 12
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210> 13
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Glu Leu Asp Glu Leu Val Tyr Leu Leu Asp Gly Pro Gly Tyr Asp 
1               5                   10                  15      


Pro Ile His Ser 
            20  


<210> 14
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Gly Glu Leu Asp Glu Leu Val Tyr Leu Leu Asp Gly Pro Gly Tyr Asp 
1               5                   10                  15      


Pro Ile His Cys Asp Val Val Thr Arg Gly Gly Ser His Leu Phe Asn 
            20                  25                  30          


Phe 
    


<210> 15
<211> 71
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
ttatcaaaaa gagtattgtc ttaaagtcta acctatagga ttcttacagc catcgagagg       60

gacacggcga a                                                            71


<210> 16
<211> 71
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ttatcaaaaa gagtattgca ttaaagtcta acctatagga atcttacagc catcgagagg       60

gacacggcga a                                                            71


<210> 17
<211> 71
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
ttatcaaaaa gagtattgtc ttaaagtcta acctatagga aaattacagc catcgagagg       60

gacacggcga a                                                            71


<210> 18
<211> 60
<212> PRT
<213> Cricetulus barabensis

<400> 18
Met Pro Lys Lys Lys Arg Lys Val Ser Asn Leu Leu Thr Val His Gln 
1               5                   10                  15      


Asn Leu Pro Ala Leu Pro Val Asp Ala Thr Ser Asp Glu Val Arg Lys 
            20                  25                  30          


Asn Leu Met Asp Met Phe Arg Asp Arg Gln Ala Phe Ser Glu His Thr 
        35                  40                  45              


Trp Lys Met Leu Leu Ser Val Cys Arg Ser Trp Ala 
    50                  55                  60  


<210> 19
<211> 53
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Enterobacteria phage P7 sequence

<400> 19
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 20
<211> 53
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Enterobacteria phage phiW39 sequence

<400> 20
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 21
<211> 53
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Enterobacteriaceae bacterium 8376wB8 sequence

<400> 21
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 22
<211> 53
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Enterobacteriaceae bacterium 8376wD8 sequence

<400> 22
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 23
<211> 53
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Enterobacteriaceae bacterium 8376wD9 sequence

<400> 23
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 24
<211> 53
<212> PRT
<213> Escherichia albertii

<400> 24
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 25
<211> 53
<212> PRT
<213> Escherichia coli

<400> 25
Met Ser Asn Val Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 26
<211> 53
<212> PRT
<213> Escherichia fergusonii

<400> 26
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 27
<211> 53
<212> PRT
<213> Escherichia sp.

<400> 27
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 28
<211> 53
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Escherichia phage P1 sequence

<400> 28
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 29
<211> 53
<212> PRT
<213> Klebsiella pneumoniae

<400> 29
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 30
<211> 53
<212> PRT
<213> Salmonella sp.

<400> 30
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 31
<211> 53
<212> PRT
<213> Salmonella enterica

<400> 31
Met Thr Asn Ser Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Glu Ser Val Asn Glu Glu Val Arg Arg Asn Leu Asn Ala Met Phe Arg 
            20                  25                  30          


Asp Lys Glu Ala Phe Ser Glu His Thr Trp Lys Met Leu Met Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 32
<211> 53
<212> PRT
<213> Salmonella enterica

<400> 32
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 33
<211> 53
<212> PRT
<213> Salmonella enterica

<400> 33
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 34
<211> 53
<212> PRT
<213> Salmonella sp.

<400> 34
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 35
<211> 53
<212> PRT
<213> Salmonella sp.

<400> 35
Met Thr Asn Ser Leu Thr Val His Gln Asn Leu Leu Ala Leu Pro Val 
1               5                   10                  15      


Glu Ser Val Asn Glu Glu Val Leu Arg Asn Leu Asn Ala Met Phe Arg 
            20                  25                  30          


Asp Lys Glu Ala Phe Ser Glu His Thr Trp Lys Met Leu Met Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 36
<211> 53
<212> PRT
<213> Salmonella sp.

<400> 36
Met Thr Asn Ser Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Glu Ser Val Asn Glu Glu Val Arg Arg Asn Leu Asn Ala Met Phe Arg 
            20                  25                  30          


Asp Lys Glu Ala Phe Ser Glu His Thr Trp Lys Met Leu Met Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 37
<211> 53
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Salmonella phage SJ46 sequence

<400> 37
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 38
<211> 53
<212> PRT
<213> Salmonella sp.

<400> 38
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 39
<211> 53
<212> PRT
<213> Salmonella typhimurium

<400> 39
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg His Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 40
<211> 53
<212> PRT
<213> Shigella dysenteriae

<400> 40
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 41
<211> 53
<212> PRT
<213> Shigella sonnei

<400> 41
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala 
    50              


<210> 42

<400> 42
000


<210> 43

<400> 43
000


<210> 44

<400> 44
000


<210> 45

<400> 45
000


<210> 46

<400> 46
000


<210> 47

<400> 47
000


<210> 48

<400> 48
000


<210> 49

<400> 49
000


<210> 50

<400> 50
000


<210> 51

<400> 51
000


<210> 52

<400> 52
000


<210> 53

<400> 53
000


<210> 54

<400> 54
000


<210> 55

<400> 55
000


<210> 56

<400> 56
000


<210> 57

<400> 57
000


<210> 58
<211> 343
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cre reconbinase sequence

<400> 58
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe 
    50                  55                  60                  


Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala 
65                  70                  75                  80  


Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn 
                85                  90                  95      


Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala 
            100                 105                 110         


Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly 
        115                 120                 125             


Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln 
    130                 135                 140                 


Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn 
145                 150                 155                 160 


Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu 
                165                 170                 175     


Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg 
            180                 185                 190         


Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly 
        195                 200                 205             


Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp 
    210                 215                 220                 


Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys 
225                 230                 235                 240 


Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu 
                245                 250                 255     


Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile 
            260                 265                 270         


Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly 
        275                 280                 285             


His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val 
    290                 295                 300                 


Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile 
305                 310                 315                 320 


Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val 
                325                 330                 335     


Arg Leu Leu Glu Asp Gly Asp 
            340             


<210> 59
<211> 34
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      LoxP sequence


<220>
<221> modified_base
<222> (14)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(21)
<223> a, c, t, g, unknown or other

<400> 59
ataacttcgt atannntann ntatacgaag ttat                                   34


<210> 60
<211> 423
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Flp or FlpO recombinase sequence

<400> 60
Met Ser Gln Phe Asp Ile Leu Cys Lys Thr Pro Pro Lys Val Leu Val 
1               5                   10                  15      


Arg Gln Phe Val Glu Arg Phe Glu Arg Pro Ser Gly Glu Lys Ile Ala 
            20                  25                  30          


Ser Cys Ala Ala Glu Leu Thr Tyr Leu Cys Trp Met Ile Thr His Asn 
        35                  40                  45              


Gly Thr Ala Ile Lys Arg Ala Thr Phe Met Ser Tyr Asn Thr Ile Ile 
    50                  55                  60                  


Ser Asn Ser Leu Ser Phe Asp Ile Val Asn Lys Ser Leu Gln Phe Lys 
65                  70                  75                  80  


Tyr Lys Thr Gln Lys Ala Thr Ile Leu Glu Ala Ser Leu Lys Lys Leu 
                85                  90                  95      


Ile Pro Ala Trp Glu Phe Thr Ile Ile Pro Tyr Asn Gly Gln Lys His 
            100                 105                 110         


Gln Ser Asp Ile Thr Asp Ile Val Ser Ser Leu Gln Leu Gln Phe Glu 
        115                 120                 125             


Ser Ser Glu Glu Ala Asp Lys Gly Asn Ser His Ser Lys Lys Met Leu 
    130                 135                 140                 


Lys Ala Leu Leu Ser Glu Gly Glu Ser Ile Trp Glu Ile Thr Glu Lys 
145                 150                 155                 160 


Ile Leu Asn Ser Phe Glu Tyr Thr Ser Arg Phe Thr Lys Thr Lys Thr 
                165                 170                 175     


Leu Tyr Gln Phe Leu Phe Leu Ala Thr Phe Ile Asn Cys Gly Arg Phe 
            180                 185                 190         


Ser Asp Ile Lys Asn Val Asp Pro Lys Ser Phe Lys Leu Val Gln Asn 
        195                 200                 205             


Lys Tyr Leu Gly Val Ile Ile Gln Cys Leu Val Thr Glu Thr Lys Thr 
    210                 215                 220                 


Ser Val Ser Arg His Ile Tyr Phe Phe Ser Ala Arg Gly Arg Ile Asp 
225                 230                 235                 240 


Pro Leu Val Tyr Leu Asp Glu Phe Leu Arg Asn Ser Glu Pro Val Leu 
                245                 250                 255     


Lys Arg Val Asn Arg Thr Gly Asn Ser Ser Ser Asn Lys Gln Glu Tyr 
            260                 265                 270         


Gln Leu Leu Lys Asp Asn Leu Val Arg Ser Tyr Asn Lys Ala Leu Lys 
        275                 280                 285             


Lys Asn Ala Pro Tyr Pro Ile Phe Ala Ile Lys Asn Gly Pro Lys Ser 
    290                 295                 300                 


His Ile Gly Arg His Leu Met Thr Ser Phe Leu Ser Met Lys Gly Leu 
305                 310                 315                 320 


Thr Glu Leu Thr Asn Val Val Gly Asn Trp Ser Asp Lys Arg Ala Ser 
                325                 330                 335     


Ala Val Ala Arg Thr Thr Tyr Thr His Gln Ile Thr Ala Ile Pro Asp 
            340                 345                 350         


His Tyr Phe Ala Leu Val Ser Arg Tyr Tyr Ala Tyr Asp Pro Ile Ser 
        355                 360                 365             


Lys Glu Met Ile Ala Leu Lys Asp Glu Thr Asn Pro Ile Glu Glu Trp 
    370                 375                 380                 


Gln His Ile Glu Gln Leu Lys Gly Ser Ala Glu Gly Ser Ile Arg Tyr 
385                 390                 395                 400 


Pro Ala Trp Asn Gly Ile Ile Ser Gln Glu Val Leu Asp Tyr Leu Ser 
                405                 410                 415     


Ser Tyr Ile Asn Arg Arg Ile 
            420             


<210> 61
<211> 34
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      FRT sequence 

<400> 61
gaagttccta ttctctagaa agtataggaa cttc                                   34


<210> 62

<400> 62
000


<210> 63

<400> 63
000


<210> 64

<400> 64
000


<210> 65
<211> 380
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      VCre recombinase sequence

<400> 65
Met Ile Glu Asn Gln Leu Ser Leu Leu Gly Asp Phe Ser Gly Val Arg 
1               5                   10                  15      


Pro Asp Asp Val Lys Thr Ala Ile Gln Ala Ala Gln Lys Lys Gly Ile 
            20                  25                  30          


Asn Val Ala Glu Asn Glu Gln Phe Lys Ala Ala Phe Glu His Leu Leu 
        35                  40                  45              


Asn Glu Phe Lys Lys Arg Glu Glu Arg Tyr Ser Pro Asn Thr Leu Arg 
    50                  55                  60                  


Arg Leu Glu Ser Ala Trp Thr Cys Phe Val Asp Trp Cys Leu Ala Asn 
65                  70                  75                  80  


His Arg His Ser Leu Pro Ala Thr Pro Asp Thr Val Glu Ala Phe Phe 
                85                  90                  95      


Ile Glu Arg Ala Glu Glu Leu His Arg Asn Thr Leu Ser Val Tyr Arg 
            100                 105                 110         


Trp Ala Ile Ser Arg Val His Arg Val Ala Gly Cys Pro Asp Pro Cys 
        115                 120                 125             


Leu Asp Ile Tyr Val Glu Asp Arg Leu Lys Ala Ile Ala Arg Lys Lys 
    130                 135                 140                 


Val Arg Glu Gly Glu Ala Val Lys Gln Ala Ser Pro Phe Asn Glu Gln 
145                 150                 155                 160 


His Leu Leu Lys Leu Thr Ser Leu Trp Tyr Arg Ser Asp Lys Leu Leu 
                165                 170                 175     


Leu Arg Arg Asn Leu Ala Leu Leu Ala Val Ala Tyr Glu Ser Met Leu 
            180                 185                 190         


Arg Ala Ser Glu Leu Ala Asn Ile Arg Val Ser Asp Met Glu Leu Ala 
        195                 200                 205             


Gly Asp Gly Thr Ala Ile Leu Thr Ile Pro Ile Thr Lys Thr Asn His 
    210                 215                 220                 


Ser Gly Glu Pro Asp Thr Cys Ile Leu Ser Gln Asp Val Val Ser Leu 
225                 230                 235                 240 


Leu Met Asp Tyr Thr Glu Ala Gly Lys Leu Asp Met Ser Ser Asp Gly 
                245                 250                 255     


Phe Leu Phe Val Gly Val Ser Lys His Asn Thr Cys Ile Lys Pro Lys 
            260                 265                 270         


Lys Asp Lys Gln Thr Gly Glu Val Leu His Lys Pro Ile Thr Thr Lys 
        275                 280                 285             


Thr Val Glu Gly Val Phe Tyr Ser Ala Trp Glu Thr Leu Asp Leu Gly 
    290                 295                 300                 


Arg Gln Gly Val Lys Pro Phe Thr Ala His Ser Ala Arg Val Gly Ala 
305                 310                 315                 320 


Ala Gln Asp Leu Leu Lys Lys Gly Tyr Asn Thr Leu Gln Ile Gln Gln 
                325                 330                 335     


Ser Gly Arg Trp Ser Ser Gly Ala Met Val Ala Arg Tyr Gly Arg Ala 
            340                 345                 350         


Ile Leu Ala Arg Asp Gly Ala Met Ala His Ser Arg Val Lys Thr Arg 
        355                 360                 365             


Ser Ala Pro Met Gln Trp Gly Lys Asp Glu Lys Asp 
    370                 375                 380 


<210> 66
<211> 34
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      VLoxP sequence

<400> 66
tcaatttctg agaactgtca ttctcggaaa ttga                                   34


<210> 67

<400> 67
000


<210> 68

<400> 68
000


<210> 69

<400> 69
000


<210> 70

<400> 70
000


<210> 71

<400> 71
000


<210> 72

<400> 72
000


<210> 73

<400> 73
000


<210> 74

<400> 74
000


<210> 75

<400> 75
000


<210> 76

<400> 76
000


<210> 77

<400> 77
000


<210> 78

<400> 78
000


<210> 79

<400> 79
000


<210> 80

<400> 80
000


<210> 81

<400> 81
000


<210> 82

<400> 82
000


<210> 83

<400> 83
000


<210> 84

<400> 84
000


<210> 85

<400> 85
000


<210> 86

<400> 86
000


<210> 87

<400> 87
000


<210> 88

<400> 88
000


<210> 89
<211> 189
<212> PRT
<213> Hepacivirus C

<400> 89
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys 
1               5                   10                  15      


Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
            20                  25                  30          


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile 
        35                  40                  45              


Asn Gly Val Cys Trp Ala Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
    50                  55                  60                  


Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
    130                 135                 140                 


Cys Pro Ala Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu 
                165                 170                 175     


Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser 
            180                 185                 


<210> 90
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 90
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys 
1               5                   10                  15      


Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
            20                  25                  30          


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile 
        35                  40                  45              


Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
    50                  55                  60                  


Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
    130                 135                 140                 


Cys Pro Ala Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu 
                165                 170                 175     


Thr Thr Met Arg 
            180 


<210> 91
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 91
Ala Pro Ile Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Leu Gly Cys 
1               5                   10                  15      


Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
            20                  25                  30          


Val Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Cys Val 
        35                  40                  45              


Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Ser Lys Thr Leu 
    50                  55                  60                  


Ala Gly Pro Lys Gly Pro Ile Thr Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Gln Ala Pro Pro Gly Ala Arg Ser Leu Thr Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Val Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
    130                 135                 140                 


Cys Pro Ser Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Val Asp Phe Val Pro Val Glu Ser Met Glu 
                165                 170                 175     


Thr Thr Met Arg 
            180 


<210> 92
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 92
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Thr 
1               5                   10                  15      


Ile Val Val Ser Met Thr Gly Arg Asp Lys Thr Glu Gln Ala Gly Glu 
            20                  25                  30          


Ile Gln Val Leu Ser Thr Val Thr Gln Ser Phe Leu Gly Thr Ser Ile 
        35                  40                  45              


Ser Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Asn Lys Thr Leu 
    50                  55                  60                  


Ala Gly Ser Arg Gly Pro Val Thr Gln Met Tyr Ser Ser Ala Glu Gly 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ser Pro Pro Gly Thr Lys Ser Leu Glu Pro 
                85                  90                  95      


Cys Thr Cys Gly Ala Val Asp Leu Tyr Leu Val Thr Arg Asn Ala Asp 
            100                 105                 110         


Val Ile Pro Ala Arg Arg Arg Gly Asp Lys Arg Gly Ala Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Leu Ser Thr Leu Lys Gly Ser Ser Gly Gly Pro Val Leu 
    130                 135                 140                 


Cys Pro Arg Gly His Ala Val Gly Val Phe Arg Ala Ala Val Cys Ser 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ser Ile Asp Phe Ile Pro Val Glu Thr Leu Asp 
                165                 170                 175     


Ile Val Thr Arg 
            180 


<210> 93
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 93
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Thr 
1               5                   10                  15      


Ile Val Thr Ser Leu Thr Gly Arg Asp Lys Asn Val Val Thr Gly Glu 
            20                  25                  30          


Val Gln Val Leu Ser Thr Ala Thr Gln Thr Phe Leu Gly Thr Thr Val 
        35                  40                  45              


Gly Gly Val Ile Trp Thr Val Tyr His Gly Ala Gly Ser Arg Thr Leu 
    50                  55                  60                  


Ala Gly Ala Lys His Pro Ala Leu Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Pro Gly Ala Lys Ser Leu Glu Pro 
                85                  90                  95      


Cys Ala Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg Asp Ala Asp 
            100                 105                 110         


Val Ile Pro Ala Arg Arg Arg Gly Asp Ser Thr Ala Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Leu Ala Cys Leu Lys Gly Ser Ser Gly Gly Pro Val Met 
    130                 135                 140                 


Cys Pro Ser Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ser Leu Gln Phe Ile Pro Val Glu Thr Leu Ser 
                165                 170                 175     


Thr Gln Ala Arg 
            180 


<210> 94
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 94
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Phe Ser Thr 
1               5                   10                  15      


Ile Val Thr Ser Leu Thr Gly Arg Asp Thr Asn Glu Asn Cys Gly Glu 
            20                  25                  30          


Val Gln Val Leu Ser Thr Ala Thr Gln Ser Phe Leu Gly Thr Ala Val 
        35                  40                  45              


Asn Gly Val Met Trp Thr Val Tyr His Gly Ala Gly Ala Lys Thr Ile 
    50                  55                  60                  


Ser Gly Pro Lys Gly Pro Val Asn Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Pro Gly Val Arg Ser Leu Ala Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ala Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Arg Gly Asp Thr Arg Gly Ala Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Ile Ser Ile Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
    130                 135                 140                 


Cys Pro Met Gly His Arg Ala Gly Ile Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Val Asp Phe Val Pro Val Glu Ser Leu Glu 
                165                 170                 175     


Thr Thr Met Arg 
            180 


<210> 95
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 95
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Val Leu Gly Ala 
1               5                   10                  15      


Ile Val Leu Ser Leu Thr Gly Arg Asp Lys Asn Glu Ala Glu Gly Glu 
            20                  25                  30          


Val Gln Phe Leu Ser Thr Ala Thr Gln Thr Phe Leu Gly Ile Cys Ile 
        35                  40                  45              


Asn Gly Val Met Trp Thr Leu Phe His Gly Ala Gly Ser Lys Thr Leu 
    50                  55                  60                  


Ala Gly Pro Lys Gly Pro Val Val Gln Met Tyr Thr Asn Val Asp Lys 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ser Pro Pro Gly Lys Gly Ser Leu Thr Arg 
                85                  90                  95      


Cys Thr Cys Gly Ser Ala Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Ala Arg Arg Arg Gly Asp Thr Arg Ala Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Ile Met 
    130                 135                 140                 


Cys Pro Ser Gly His Val Val Gly Val Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Leu Glu Phe Val Pro Val Glu Asn Leu Glu 
                165                 170                 175     


Thr Thr Met Arg 
            180 


<210> 96
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 96
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Val Gly Thr 
1               5                   10                  15      


Ile Val Thr Ser Leu Thr Gly Arg Asp Lys Asn Glu Ala Glu Gly Glu 
            20                  25                  30          


Val Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Thr Ile 
        35                  40                  45              


Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Ser Lys Asn Leu 
    50                  55                  60                  


Ala Gly Pro Lys Gly Pro Val Cys Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Leu Gly Ala Arg Ser Leu Ala Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg Gly Ala Asp 
            100                 105                 110         


Val Ile Pro Ala Arg Arg Arg Gly Asp Thr Arg Ala Ala Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Ile Ser Thr Leu Lys Gly Ser Ser Gly Gly Pro Leu Met 
    130                 135                 140                 


Cys Pro Ser Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Leu Asp Phe Ile Pro Val Glu Asn Met Asp 
                165                 170                 175     


Thr Thr Met Arg 
            180 


<210> 97
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 97
Ala Pro Ile Ser Ala Tyr Ala Gln Gln Thr Arg Gly Leu Ile Ser Thr 
1               5                   10                  15      


Leu Val Val Ser Leu Thr Gly Arg Asp Lys Asn Glu Thr Ala Gly Glu 
            20                  25                  30          


Val Gln Val Leu Ser Thr Ser Thr Gln Thr Phe Leu Gly Thr Asn Val 
        35                  40                  45              


Gly Gly Val Met Trp Gly Pro Tyr His Gly Ala Gly Thr Arg Thr Val 
    50                  55                  60                  


Ala Gly Arg Gly Gly Pro Val Leu Gln Met Tyr Thr Ser Val Ser Asp 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Pro Gly Ser Lys Ser Leu Glu Pro 
                85                  90                  95      


Cys Ser Cys Gly Ser Ala Asp Leu Tyr Leu Val Thr Arg Asn Ala Asp 
            100                 105                 110         


Val Leu Pro Leu Arg Arg Lys Gly Asp Gly Thr Ala Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Val Ser Ser Leu Lys Gly Ser Ser Gly Gly Pro Val Leu 
    130                 135                 140                 


Cys Pro Gln Ser His Cys Val Gly Ile Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Val Gln Phe Val Pro Ile Glu Lys Met Gln 
                165                 170                 175     


Val Ala Gln Arg 
            180 


<210> 98
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 98
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys 
1               5                   10                  15      


Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
            20                  25                  30          


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile 
        35                  40                  45              


Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
    50                  55                  60                  


Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
    130                 135                 140                 


Cys Pro Ala Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Thr Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu 
                165                 170                 175     


Thr Thr Met Arg 
            180 


<210> 99
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 99
Ala Pro Ile Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Leu Gly Cys 
1               5                   10                  15      


Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
            20                  25                  30          


Val Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Cys Val 
        35                  40                  45              


Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Ser Lys Thr Leu 
    50                  55                  60                  


Ala Ala Pro Lys Gly Pro Ile Thr Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Lys Pro Pro Gly Ala Arg Ser Leu Thr Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Val Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
    130                 135                 140                 


Cys Pro Phe Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Val Asp Phe Val Pro Val Glu Ser Met Glu 
                165                 170                 175     


Thr Thr Met Arg 
            180 


<210> 100
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 100
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Thr 
1               5                   10                  15      


Ile Val Val Ser Met Thr Gly Arg Asp Lys Thr Glu Gln Ala Gly Glu 
            20                  25                  30          


Ile Gln Val Leu Ser Thr Val Thr Gln Ser Phe Leu Gly Thr Thr Ile 
        35                  40                  45              


Ser Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Asn Lys Thr Leu 
    50                  55                  60                  


Ala Gly Ser Arg Gly Pro Val Thr Gln Met Tyr Ser Ser Ala Glu Gly 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ser Pro Pro Gly Thr Lys Ser Leu Glu Pro 
                85                  90                  95      


Cys Thr Cys Gly Ala Val Asp Leu Tyr Leu Val Thr Arg Asn Ala Asp 
            100                 105                 110         


Val Ile Pro Ala Arg Arg Arg Gly Asp Lys Arg Gly Ala Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Leu Ser Thr Leu Lys Gly Ser Ser Gly Gly Pro Val Leu 
    130                 135                 140                 


Cys Pro Arg Gly His Ala Val Gly Val Phe Arg Ala Ala Val Cys Ser 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ser Ile Asp Phe Ile Pro Val Glu Thr Leu Asp 
                165                 170                 175     


Ile Val Thr Arg 
            180 


<210> 101
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 101
Ala Pro Ile Thr Ala Tyr Thr Gln Gln Thr Arg Gly Leu Leu Gly Ala 
1               5                   10                  15      


Ile Val Val Ser Leu Thr Gly Arg Asp Lys Asn Glu Gln Ala Gly Gln 
            20                  25                  30          


Val Gln Val Leu Ser Ser Val Thr Gln Thr Phe Leu Gly Thr Ser Ile 
        35                  40                  45              


Ser Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Asn Lys Thr Leu 
    50                  55                  60                  


Ala Gly Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Ser Ala Glu Gly 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ser Pro Pro Gly Thr Lys Ser Leu Asp Pro 
                85                  90                  95      


Cys Thr Cys Gly Ala Val Asp Leu Tyr Leu Val Thr Arg Asn Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Lys Asp Asp Arg Arg Gly Ala Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Leu Ser Thr Leu Lys Gly Ser Ser Gly Gly Pro Val Leu 
    130                 135                 140                 


Cys Ser Arg Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Ala 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ser Ile Asp Phe Ile Pro Val Glu Ser Leu Asp 
                165                 170                 175     


Val Ala Thr Arg 
            180 


<210> 102
<211> 180
<212> PRT
<213> Hepacivirus C

<400> 102
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Thr 
1               5                   10                  15      


Ile Val Thr Ser Leu Thr Gly Arg Asp Lys Asn Val Val Thr Gly Glu 
            20                  25                  30          


Val Gln Val Leu Ser Thr Ala Thr Gln Thr Phe Leu Gly Thr Thr Val 
        35                  40                  45              


Gly Gly Val Ile Trp Thr Val Tyr His Gly Ala Gly Ser Arg Thr Leu 
    50                  55                  60                  


Ala Gly Ala Lys His Pro Ala Leu Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Pro Gly Ala Lys Ser Leu Glu Pro 
                85                  90                  95      


Cys Ala Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg Asp Ala Asp 
            100                 105                 110         


Val Ile Pro Ala Arg Arg Arg Gly Asp Ser Thr Ala Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Leu Ala Cys Leu Lys Gly Ser Ser Gly Gly Pro Val Met 
    130                 135                 140                 


Cys Pro Ser Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ser Leu Gln Phe Ile Pro Val Glu Thr Leu Ser 
                165                 170                 175     


Thr Gln Ala Arg 
            180 


<210> 103
<211> 179
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 103
Ile Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile 
1               5                   10                  15      


Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln 
            20                  25                  30          


Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Cys Val Asn Gly 
        35                  40                  45              


Val Cys Trp Thr Val Tyr His Gly Ala Gly Ser Lys Thr Leu Ala Gly 
    50                  55                  60                  


Pro Lys Gly Pro Ile Thr Gln Met Tyr Thr Asn Val Asp Gln Asp Leu 
65                  70                  75                  80  


Val Gly Trp Gln Ala Pro Pro Gly Ala Arg Ser Leu Thr Pro Cys Thr 
                85                  90                  95      


Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile 
            100                 105                 110         


Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg 
        115                 120                 125             


Pro Val Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro 
    130                 135                 140                 


Ser Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly 
145                 150                 155                 160 


Val Ala Lys Ala Val Asp Phe Val Pro Val Glu Ser Met Glu Thr Thr 
                165                 170                 175     


Met Arg Ser 
            


<210> 104
<211> 189
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys 
1               5                   10                  15      


Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
            20                  25                  30          


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile 
        35                  40                  45              


Asn Gly Val Cys Trp Ala Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
    50                  55                  60                  


Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu 
    130                 135                 140                 


Cys Pro Ala Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu 
                165                 170                 175     


Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser 
            180                 185                 


<210> 105

<400> 105
000


<210> 106

<400> 106
000


<210> 107

<400> 107
000


<210> 108

<400> 108
000


<210> 109

<400> 109
000


<210> 110

<400> 110
000


<210> 111

<400> 111
000


<210> 112

<400> 112
000


<210> 113

<400> 113
000


<210> 114

<400> 114
000


<210> 115

<400> 115
000


<210> 116

<400> 116
000


<210> 117

<400> 117
000


<210> 118

<400> 118
000


<210> 119

<400> 119
000


<210> 120

<400> 120
000


<210> 121

<400> 121
000


<210> 122

<400> 122
000


<210> 123

<400> 123
000


<210> 124

<400> 124
000


<210> 125

<400> 125
000


<210> 126

<400> 126
000


<210> 127

<400> 127
000


<210> 128

<400> 128
000


<210> 129

<400> 129
000


<210> 130

<400> 130
000


<210> 131

<400> 131
000


<210> 132

<400> 132
000


<210> 133

<400> 133
000


<210> 134

<400> 134
000


<210> 135

<400> 135
000


<210> 136

<400> 136
000


<210> 137

<400> 137
000


<210> 138

<400> 138
000


<210> 139

<400> 139
000


<210> 140

<400> 140
000


<210> 141

<400> 141
000


<210> 142

<400> 142
000


<210> 143

<400> 143
000


<210> 144

<400> 144
000


<210> 145

<400> 145
000


<210> 146

<400> 146
000


<210> 147

<400> 147
000


<210> 148

<400> 148
000


<210> 149

<400> 149
000


<210> 150

<400> 150
000


<210> 151

<400> 151
000


<210> 152

<400> 152
000


<210> 153

<400> 153
000


<210> 154
<211> 182
<212> PRT
<213> Hepacivirus C

<400> 154
Met Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly 
1               5                   10                  15      


Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly 
            20                  25                  30          


Glu Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys 
        35                  40                  45              


Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr 
    50                  55                  60                  


Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp 
65                  70                  75                  80  


Lys Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr 
                85                  90                  95      


Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
            100                 105                 110         


Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu 
        115                 120                 125             


Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu 
    130                 135                 140                 


Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys 
145                 150                 155                 160 


Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu 
                165                 170                 175     


Glu Thr Thr Met Arg Ser 
            180         


<210> 155
<211> 195
<212> PRT
<213> Hepacivirus C

<400> 155
Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Val Leu Asn 
1               5                   10                  15      


Gly Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr 
            20                  25                  30          


Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile 
        35                  40                  45              


Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly Val 
    50                  55                  60                  


Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro 
65                  70                  75                  80  


Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val 
                85                  90                  95      


Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys 
            100                 105                 110         


Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro 
        115                 120                 125             


Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro 
    130                 135                 140                 


Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala 
145                 150                 155                 160 


Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
                165                 170                 175     


Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met 
            180                 185                 190         


Arg Ser Pro 
        195 


<210> 156
<211> 195
<212> PRT
<213> Hepacivirus C

<400> 156
Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Val Leu Asn 
1               5                   10                  15      


Gly Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr 
            20                  25                  30          


Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile 
        35                  40                  45              


Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly Val 
    50                  55                  60                  


Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro 
65                  70                  75                  80  


Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val 
                85                  90                  95      


Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys 
            100                 105                 110         


Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro 
        115                 120                 125             


Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro 
    130                 135                 140                 


Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala 
145                 150                 155                 160 


Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
                165                 170                 175     


Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met 
            180                 185                 190         


Arg Ser Pro 
        195 


<210> 157
<211> 197
<212> PRT
<213> Hepacivirus C

<400> 157
Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys Ile Asn 
    50                  55                  60                  


Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro 
        195         


<210> 158
<211> 197
<212> PRT
<213> Hepacivirus C

<400> 158
Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile Asn 
    50                  55                  60                  


Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro 
        195         


<210> 159
<211> 197
<212> PRT
<213> Hepacivirus C

<400> 159
Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro 
        195         


<210> 160
<211> 197
<212> PRT
<213> Hepacivirus C

<400> 160
Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Gln Gly Cys Gln 
            20                  25                  30          


Lys Thr Ser His Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro 
        195         


<210> 161
<211> 197
<212> PRT
<213> Hepacivirus C

<400> 161
Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Gln Gly Thr Gln 
            20                  25                  30          


Lys Thr Ser His Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro 
        195         


<210> 162
<211> 196
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 162
Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly 
1               5                   10                  15      


Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu 
            20                  25                  30          


Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln 
        35                  40                  45              


Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly 
    50                  55                  60                  


Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser 
65                  70                  75                  80  


Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu 
                85                  90                  95      


Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr 
            100                 105                 110         


Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile 
        115                 120                 125             


Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg 
    130                 135                 140                 


Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro 
145                 150                 155                 160 


Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly 
                165                 170                 175     


Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr 
            180                 185                 190         


Met Arg Ser Pro 
        195     


<210> 163

<400> 163
000


<210> 164

<400> 164
000


<210> 165

<400> 165
000


<210> 166

<400> 166
000


<210> 167

<400> 167
000


<210> 168

<400> 168
000


<210> 169

<400> 169
000


<210> 170

<400> 170
000


<210> 171

<400> 171
000


<210> 172

<400> 172
000


<210> 173

<400> 173
000


<210> 174

<400> 174
000


<210> 175

<400> 175
000


<210> 176

<400> 176
000


<210> 177

<400> 177
000


<210> 178

<400> 178
000


<210> 179

<400> 179
000


<210> 180

<400> 180
000


<210> 181

<400> 181
000


<210> 182

<400> 182
000


<210> 183

<400> 183
000


<210> 184

<400> 184
000


<210> 185

<400> 185
000


<210> 186

<400> 186
000


<210> 187

<400> 187
000


<210> 188

<400> 188
000


<210> 189

<400> 189
000


<210> 190
<211> 306
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 190
Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
1               5                   10                  15      


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
            20                  25                  30          


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40                  45              


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
    50                  55                  60                  


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
65                  70                  75                  80  


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
                85                  90                  95      


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
            100                 105                 110         


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
        115                 120                 125             


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
    130                 135                 140                 


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
145                 150                 155                 160 


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
                165                 170                 175     


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
            180                 185                 190         


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
        195                 200                 205             


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
    210                 215                 220                 


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
225                 230                 235                 240 


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
                245                 250                 255     


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
            260                 265                 270         


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
        275                 280                 285             


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
    290                 295                 300                 


Leu Ser 
305     


<210> 191
<211> 358
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 191
Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro 
1               5                   10                  15      


Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn 
            20                  25                  30          


Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly 
        35                  40                  45              


Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu 
    50                  55                  60                  


Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn 
65                  70                  75                  80  


His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp 
                85                  90                  95      


Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser 
            100                 105                 110         


Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp 
        115                 120                 125             


Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp 
    130                 135                 140                 


Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys 
145                 150                 155                 160 


Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val 
                165                 170                 175     


Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro 
            180                 185                 190         


Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser 
        195                 200                 205             


His Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln 
    210                 215                 220                 


Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His 
225                 230                 235                 240 


Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro 
                245                 250                 255     


Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile 
            260                 265                 270         


Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln 
        275                 280                 285             


Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu 
    290                 295                 300                 


Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu 
305                 310                 315                 320 


Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His 
                325                 330                 335     


Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
            340                 345                 350         


Cys Gly Val Leu Leu Ser 
        355             


<210> 192
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 192
Asp Asp Ile Val Pro Cys 
1               5       


<210> 193
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 193
Asp Glu Met Glu Glu Cys 
1               5       


