                         SEQUENCE LISTING

<110>  Manus Bio Inc.
       KUMARAN, Ajikumar Parayil
       SANTOS, Christine Nicole S
       SARRIA, Stephen S
       DONALD, Jason
       ZHENG, Yiying
       LI, Liwei
       NIEMINEN, Eric
       GOETTGE, Michelle
 
<120>  MICROBIAL PRODUCTION OF ARTEMISINIC ACID AND DERIVATIVES

<130>  MAN-026PC/107590-5025

<140>  PCT/US21/47694
<141>  2021-08-26

<150>  US 63/071,630
<151>  2020-08-28

<160>  488   

<170>  PatentIn version 3.5

<210>  1
<211>  546
<212>  PRT
<213>  Artemisia annua

<400>  1

Met Ser Leu Thr Glu Glu Lys Pro Ile Arg Pro Ile Ala Asn Phe Pro 
1               5                   10                  15      


Pro Ser Ile Trp Gly Asp Gln Phe Leu Ile Tyr Glu Lys Gln Val Glu 
            20                  25                  30          


Gln Gly Val Glu Gln Ile Val Asn Asp Leu Lys Lys Glu Val Arg Gln 
        35                  40                  45              


Leu Leu Lys Glu Ala Leu Asp Ile Pro Met Lys His Ala Asn Leu Leu 
    50                  55                  60                  


Lys Leu Ile Asp Glu Ile Gln Arg Leu Gly Ile Pro Tyr His Phe Glu 
65                  70                  75                  80  


Arg Glu Ile Asp His Ala Leu Gln Cys Ile Tyr Glu Thr Tyr Gly Asp 
                85                  90                  95      


Asn Trp Asn Gly Asp Arg Ser Ser Leu Trp Phe Arg Leu Met Arg Lys 
            100                 105                 110         


Gln Gly Tyr Tyr Val Thr Cys Asp Val Phe Asn Asn Tyr Lys Asp Lys 
        115                 120                 125             


Asn Gly Ala Phe Lys Gln Ser Leu Ala Asn Asp Val Glu Gly Leu Leu 
    130                 135                 140                 


Glu Leu Tyr Glu Ala Thr Ser Met Arg Val Pro Gly Glu Ile Ile Leu 
145                 150                 155                 160 


Glu Asp Ala Leu Gly Phe Thr Arg Ser Arg Leu Ser Ile Met Thr Lys 
                165                 170                 175     


Asp Ala Phe Ser Thr Asn Pro Ala Leu Phe Thr Glu Ile Gln Arg Ala 
            180                 185                 190         


Leu Lys Gln Pro Leu Trp Lys Arg Leu Pro Arg Ile Glu Ala Ala Gln 
        195                 200                 205             


Tyr Ile Pro Phe Tyr Gln Gln Gln Asp Ser His Asn Lys Thr Leu Leu 
    210                 215                 220                 


Lys Leu Ala Lys Leu Glu Phe Asn Leu Leu Gln Ser Leu His Lys Glu 
225                 230                 235                 240 


Glu Leu Ser His Val Cys Lys Trp Trp Lys Ala Phe Asp Ile Lys Lys 
                245                 250                 255     


Asn Ala Pro Cys Leu Arg Asp Arg Ile Val Glu Cys Tyr Phe Trp Gly 
            260                 265                 270         


Leu Gly Ser Gly Tyr Glu Pro Gln Tyr Ser Arg Ala Arg Val Phe Phe 
        275                 280                 285             


Thr Lys Ala Val Ala Val Ile Thr Leu Ile Asp Asp Thr Tyr Asp Ala 
    290                 295                 300                 


Tyr Gly Thr Tyr Glu Glu Leu Lys Ile Phe Thr Glu Ala Val Glu Arg 
305                 310                 315                 320 


Trp Ser Ile Thr Cys Leu Asp Thr Leu Pro Glu Tyr Met Lys Pro Ile 
                325                 330                 335     


Tyr Lys Leu Phe Met Asp Thr Tyr Thr Glu Met Glu Glu Phe Leu Ala 
            340                 345                 350         


Lys Glu Gly Arg Thr Asp Leu Phe Asn Cys Gly Lys Glu Phe Val Lys 
        355                 360                 365             


Glu Phe Val Arg Asn Leu Met Val Glu Ala Lys Trp Ala Asn Glu Gly 
    370                 375                 380                 


His Ile Pro Thr Thr Glu Glu His Asp Pro Val Val Ile Ile Thr Gly 
385                 390                 395                 400 


Gly Ala Asn Leu Leu Thr Thr Thr Cys Tyr Leu Gly Met Ser Asp Ile 
                405                 410                 415     


Phe Thr Lys Glu Ser Val Glu Trp Ala Val Ser Ala Pro Pro Leu Phe 
            420                 425                 430         


Arg Tyr Ser Gly Ile Leu Gly Arg Arg Leu Asn Asp Leu Met Thr His 
        435                 440                 445             


Lys Ala Glu Gln Glu Arg Lys His Ser Ser Ser Ser Leu Glu Ser Tyr 
    450                 455                 460                 


Met Lys Glu Tyr Asn Val Asn Glu Glu Tyr Ala Gln Thr Leu Ile Tyr 
465                 470                 475                 480 


Lys Glu Val Glu Asp Val Trp Lys Asp Ile Asn Arg Glu Tyr Leu Thr 
                485                 490                 495     


Thr Lys Asn Ile Pro Arg Pro Leu Leu Met Ala Val Ile Tyr Leu Cys 
            500                 505                 510         


Gln Phe Leu Glu Val Gln Tyr Ala Gly Lys Asp Asn Phe Thr Arg Met 
        515                 520                 525             


Gly Asp Glu Tyr Lys His Leu Ile Lys Ser Leu Leu Val Tyr Pro Met 
    530                 535                 540                 


Ser Ile 
545     


<210>  2
<211>  546
<212>  PRT
<213>  Artemisia annua

<400>  2

Met Ser Leu Thr Glu Glu Lys Pro Ile Arg Pro Ile Ala Asn Phe Pro 
1               5                   10                  15      


Pro Ser Ile Trp Gly Asp Gln Phe Leu Ile Tyr Glu Lys Gln Val Glu 
            20                  25                  30          


Gln Gly Val Glu Gln Ile Val Asn Asp Leu Lys Lys Glu Val Arg Gln 
        35                  40                  45              


Leu Leu Lys Glu Ala Leu Asp Ile Pro Met Lys His Ala Asn Leu Leu 
    50                  55                  60                  


Lys Leu Ile Asp Glu Ile Gln Arg Leu Gly Ile Pro Tyr His Phe Glu 
65                  70                  75                  80  


Arg Glu Ile Asp His Ala Leu Gln Cys Ile Tyr Glu Thr Tyr Gly Asp 
                85                  90                  95      


Asn Trp Asn Gly Asp Arg Ser Ser Leu Trp Phe Arg Leu Met Arg Lys 
            100                 105                 110         


Gln Gly Tyr Tyr Val Ser Cys Asp Val Phe Asn Asn Tyr Lys Asp Lys 
        115                 120                 125             


Asn Gly Ala Phe Lys Gln Ser Leu Ala Asn Asp Val Glu Gly Leu Leu 
    130                 135                 140                 


Glu Leu Tyr Glu Ala Thr Ser Met Arg Val Pro Gly Glu Ile Ile Leu 
145                 150                 155                 160 


Glu Glu Ala Leu Gly Phe Thr Arg Ser Arg Leu Ser Ser Met Thr Lys 
                165                 170                 175     


Asp Ala Phe Ser Thr Asn Pro Ala Leu Phe Thr Glu Ile Gln Arg Ala 
            180                 185                 190         


Leu Lys Gln Pro Leu Trp Lys Arg Leu Pro Arg Ile Glu Ala Ala Gln 
        195                 200                 205             


Tyr Ile Pro Phe Tyr Gln Gln Gln Asp Ser His Asn Lys Thr Leu Leu 
    210                 215                 220                 


Lys Leu Ala Lys Leu Glu Phe Asn Leu Leu Gln Ser Leu His Lys Glu 
225                 230                 235                 240 


Glu Leu Ser His Val Cys Lys Trp Trp Lys Ala Phe Asp Ile Lys Lys 
                245                 250                 255     


Asn Ala Pro Cys Leu Arg Asp Arg Ile Val Glu Cys Tyr Phe Trp Gly 
            260                 265                 270         


Leu Gly Ser Gly Tyr Glu Pro Gln Tyr Ser Arg Ala Arg Val Phe Phe 
        275                 280                 285             


Thr Lys Ala Val Ala Val Ile Thr Leu Ile Asp Asp Thr Tyr Asp Ala 
    290                 295                 300                 


Tyr Gly Thr Tyr Glu Glu Leu Lys Ile Phe Thr Glu Ala Val Glu Arg 
305                 310                 315                 320 


Trp Asp Ile Thr Cys Leu Asp Thr Leu Pro Glu Tyr Met Lys Pro Ile 
                325                 330                 335     


Tyr Lys Leu Phe Met Asp Thr Tyr Thr Glu Met Glu Glu Phe Leu Ala 
            340                 345                 350         


Lys Glu Gly Arg Thr Asp Leu Phe Asn Cys Ala Lys Glu Phe Val Lys 
        355                 360                 365             


Glu Phe Val Arg Asn Leu Met Val Glu Ala Lys Trp Ala Asn Glu Gly 
    370                 375                 380                 


His Ile Pro Thr Thr Glu Glu His Asp Pro Val Ala Ile Ile Thr Gly 
385                 390                 395                 400 


Gly Ala Asn Leu Leu Thr Thr Thr Cys Tyr Leu Gly Met Ser Asp Ile 
                405                 410                 415     


Phe Thr Lys Glu Ser Val Glu Trp Ala Val Ser Ala Pro Pro Leu Phe 
            420                 425                 430         


Arg Tyr Ser Gly Ile Leu Gly Arg Arg Leu Asn Asp Leu Met Thr His 
        435                 440                 445             


Lys Ala Glu Gln Glu Arg Lys His Ser Ser Ser Ser Leu Glu Ser Tyr 
    450                 455                 460                 


Met Lys Glu Tyr Asn Val Asn Glu Glu Glu Ala Gln Thr Leu Ile Tyr 
465                 470                 475                 480 


Lys Glu Val Glu Asp Val Trp Lys Asp Ile Asn Arg Glu Tyr Leu Thr 
                485                 490                 495     


Thr Lys Asn Ile Pro Arg Pro Leu Leu Met Ala Val Ile Tyr Leu Cys 
            500                 505                 510         


Gln Phe Leu Glu Val Gln Tyr Ala Gly Lys Asp Asn Phe Thr Arg Met 
        515                 520                 525             


Gly Asp Glu Tyr Lys His Leu Ile Lys Ser Leu Leu Val Tyr Pro Met 
    530                 535                 540                 


Ser Ile 
545     


<210>  3
<211>  496
<212>  PRT
<213>  Artemisia annua

<400>  3

Met Ala Lys Ser Ile Leu Lys Ala Met Ala Leu Ser Leu Thr Thr Ser 
1               5                   10                  15      


Ile Ala Leu Ala Thr Ile Leu Leu Phe Val Tyr Lys Phe Ala Thr Arg 
            20                  25                  30          


Ser Lys Ser Thr Lys Lys Ser Leu Pro Glu Pro Trp Arg Leu Pro Ile 
        35                  40                  45              


Ile Gly His Met His His Leu Ile Gly Thr Thr Pro His Arg Gly Val 
    50                  55                  60                  


Arg Asp Leu Ala Arg Lys Tyr Gly Ser Leu Met His Leu Gln Leu Gly 
65                  70                  75                  80  


Glu Val Pro Thr Ile Val Val Ser Ser Pro Lys Trp Ala Lys Glu Ile 
                85                  90                  95      


Leu Thr Thr Tyr Asp Ile Thr Phe Ala Asn Arg Pro Glu Thr Leu Thr 
            100                 105                 110         


Gly Glu Ile Val Leu Tyr His Asn Thr Asp Val Val Leu Ala Pro Tyr 
        115                 120                 125             


Gly Glu Tyr Trp Arg Gln Leu Arg Lys Ile Cys Thr Leu Glu Leu Leu 
    130                 135                 140                 


Ser Val Lys Lys Val Lys Ser Phe Gln Ser Leu Arg Glu Glu Glu Cys 
145                 150                 155                 160 


Trp Asn Leu Val Gln Glu Ile Lys Ala Ser Gly Ser Gly Arg Pro Val 
                165                 170                 175     


Asn Leu Ser Glu Asn Val Phe Lys Leu Ile Ala Thr Ile Leu Ser Arg 
            180                 185                 190         


Ala Ala Phe Gly Lys Gly Ile Lys Asp Gln Lys Glu Leu Thr Glu Ile 
        195                 200                 205             


Val Lys Glu Ile Leu Arg Gln Thr Gly Gly Phe Asp Val Ala Asp Ile 
    210                 215                 220                 


Phe Pro Ser Lys Lys Phe Leu His His Leu Ser Gly Lys Arg Ala Arg 
225                 230                 235                 240 


Leu Thr Ser Leu Arg Lys Lys Ile Asp Asn Leu Ile Asp Asn Leu Val 
                245                 250                 255     


Ala Glu His Thr Val Asn Thr Ser Ser Lys Thr Asn Glu Thr Leu Leu 
            260                 265                 270         


Asp Val Leu Leu Arg Leu Lys Asp Ser Ala Glu Phe Pro Leu Thr Ser 
        275                 280                 285             


Asp Asn Ile Lys Ala Ile Ile Leu Asp Met Phe Gly Ala Gly Thr Asp 
    290                 295                 300                 


Thr Ser Ser Ser Thr Ile Glu Trp Ala Ile Ser Glu Leu Ile Lys Cys 
305                 310                 315                 320 


Pro Lys Ala Met Glu Lys Val Gln Ala Glu Leu Arg Lys Ala Leu Asn 
                325                 330                 335     


Gly Lys Glu Lys Ile His Glu Glu Asp Ile Gln Glu Leu Ser Tyr Leu 
            340                 345                 350         


Asn Met Val Ile Lys Glu Thr Leu Arg Leu His Pro Pro Leu Pro Leu 
        355                 360                 365             


Val Leu Pro Arg Glu Cys Arg Gln Pro Val Asn Leu Ala Gly Tyr Asn 
    370                 375                 380                 


Ile Pro Asn Lys Thr Lys Leu Ile Val Asn Val Phe Ala Ile Asn Arg 
385                 390                 395                 400 


Asp Pro Glu Tyr Trp Lys Asp Ala Glu Ala Phe Ile Pro Glu Arg Phe 
                405                 410                 415     


Glu Asn Ser Ser Ala Thr Val Met Gly Ala Glu Tyr Glu Tyr Leu Pro 
            420                 425                 430         


Phe Gly Ala Gly Arg Arg Met Cys Pro Gly Ala Ala Leu Gly Leu Ala 
        435                 440                 445             


Asn Val Gln Leu Pro Leu Ala Asn Ile Leu Tyr His Phe Asn Trp Lys 
    450                 455                 460                 


Leu Pro Asn Gly Val Ser Tyr Asp Gln Ile Asp Met Thr Glu Ser Ser 
465                 470                 475                 480 


Gly Ala Thr Met Gln Arg Lys Thr Glu Leu Leu Leu Val Pro Ser Phe 
                485                 490                 495     


<210>  4
<211>  492
<212>  PRT
<213>  Artemisia annua

<400>  4

Met Ala Lys Pro Pro Leu Phe Phe Ile Val Ile Ile Gly Leu Ile Val 
1               5                   10                  15      


Val Ala Ala Ser Phe Val Tyr Lys Phe Ala Thr Arg Ser Lys Ser Thr 
            20                  25                  30          


Lys Lys Ser Leu Pro Glu Pro Trp Arg Leu Pro Ile Ile Gly His Met 
        35                  40                  45              


His His Leu Ile Gly Thr Thr Pro His Arg Gly Leu Arg Asp Leu Ala 
    50                  55                  60                  


Arg Lys Tyr Gly Pro Leu Met His Leu Gln Leu Gly Glu Val Pro Thr 
65                  70                  75                  80  


Ile Val Val Ser Ser Pro Lys Trp Ala Lys Glu Ile Leu Thr Thr Tyr 
                85                  90                  95      


Asp Ile Thr Phe Ala Asn Arg Pro Glu Thr Leu Thr Gly Glu Ile Val 
            100                 105                 110         


Leu Tyr His Asn Thr Asp Val Val Leu Ala Pro Tyr Gly Glu Tyr Trp 
        115                 120                 125             


Arg Gln Leu Arg Lys Ile Cys Thr Leu Glu Leu Leu Ser Val Lys Lys 
    130                 135                 140                 


Val Lys Ser Phe Gln Ser Ile Arg Glu Glu Glu Cys Trp Asn Leu Val 
145                 150                 155                 160 


Gln Glu Ile Lys Ala Ser Gly Ser Gly Arg Pro Val Asn Leu Ser Glu 
                165                 170                 175     


Asn Val Phe Lys Leu Ile Ala Thr Ile Leu Ser Arg Ala Ala Phe Gly 
            180                 185                 190         


Lys Gly Ile Lys Asp Gln Lys Glu Leu Thr Glu Ile Val Lys Glu Ile 
        195                 200                 205             


Leu Arg Gln Thr Gly Gly Phe Asp Val Ala Asp Ile Phe Pro Ser Lys 
    210                 215                 220                 


Lys Phe Leu His His Leu Ser Gly Lys Arg Ala Arg Leu Thr Ser Leu 
225                 230                 235                 240 


Arg Lys Lys Ile Asp Asn Leu Ile Asp Asn Leu Val Ala Glu His Thr 
                245                 250                 255     


Val Asn Thr Ser Ser Lys Thr Asn Glu Thr Leu Leu Asp Val Leu Leu 
            260                 265                 270         


Arg Leu Lys Asp Ser Ala Glu Phe Pro Leu Thr Ser Asp Asn Ile Lys 
        275                 280                 285             


Ala Ile Ile Leu Asp Met Phe Gly Ala Gly Thr Asp Thr Ser Ser Ser 
    290                 295                 300                 


Thr Ile Glu Trp Ala Ile Ser Glu Leu Ile Lys Asn Pro Arg Ala Met 
305                 310                 315                 320 


Glu Lys Val Gln Ala Glu Leu Arg Lys Ala Leu Asn Gly Lys Glu Lys 
                325                 330                 335     


Ile His Glu Glu Asp Ile Gln Glu Leu Ser Tyr Leu Asn Met Val Ile 
            340                 345                 350         


Lys Glu Thr Leu Arg Leu His Pro Pro Leu Pro Leu Leu Leu Pro Arg 
        355                 360                 365             


Glu Cys Arg Gln Pro Val Asn Leu Ala Gly Tyr Asn Ile Pro Asn Lys 
    370                 375                 380                 


Thr Lys Leu Ile Val Asn Val Phe Ala Ile Asn Arg Asp Pro Glu Tyr 
385                 390                 395                 400 


Trp Lys Asp Ala Glu Ala Phe Ile Pro Glu Arg Phe Glu Asn Ser Ser 
                405                 410                 415     


Ala Thr Val Met Gly Ala Glu Tyr Glu Tyr Leu Pro Phe Gly Ala Gly 
            420                 425                 430         


Arg Arg Met Cys Pro Gly Ala Ala Leu Gly Leu Ala Asn Val Gln Leu 
        435                 440                 445             


Pro Leu Ala Asn Ile Leu Tyr His Phe Asn Trp Lys Leu Pro Asn Gly 
    450                 455                 460                 


Val Ser Tyr Asp Gln Ile Asp Met Thr Glu Ser Ser Gly Ala Thr Met 
465                 470                 475                 480 


Gln Arg Lys Thr Glu Leu Leu Leu Val Pro Ser Phe 
                485                 490         


<210>  5
<211>  705
<212>  PRT
<213>  Artemisia annua

<400>  5

Met Ala Gln Ser Thr Thr Ser Val Lys Leu Ser Pro Phe Asp Leu Met 
1               5                   10                  15      


Thr Ala Leu Leu Asn Gly Lys Val Ser Phe Asp Thr Ser Asn Thr Ser 
            20                  25                  30          


Asp Thr Asn Ile Pro Leu Ala Val Phe Met Glu Asn Arg Glu Leu Leu 
        35                  40                  45              


Met Ile Leu Thr Thr Ser Val Ala Val Leu Ile Gly Cys Val Val Val 
    50                  55                  60                  


Leu Val Trp Arg Arg Ser Ser Ser Ala Ala Lys Lys Ala Ala Glu Ser 
65                  70                  75                  80  


Pro Val Ile Val Val Pro Lys Lys Val Thr Glu Asp Glu Val Asp Asp 
                85                  90                  95      


Gly Arg Lys Lys Val Thr Val Phe Phe Gly Thr Gln Thr Gly Thr Ala 
            100                 105                 110         


Glu Gly Phe Ala Lys Ala Leu Val Glu Glu Ala Lys Ala Arg Tyr Glu 
        115                 120                 125             


Lys Ala Val Phe Lys Val Ile Asp Leu Asp Asp Tyr Ala Ala Glu Asp 
    130                 135                 140                 


Asp Glu Tyr Glu Glu Lys Leu Lys Lys Glu Ser Leu Ala Phe Phe Phe 
145                 150                 155                 160 


Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala Ala Arg Phe 
                165                 170                 175     


Tyr Lys Trp Phe Thr Glu Gly Glu Glu Lys Gly Glu Trp Leu Asp Lys 
            180                 185                 190         


Leu Gln Tyr Ala Val Phe Gly Leu Gly Asn Arg Gln Tyr Glu His Phe 
        195                 200                 205             


Asn Lys Ile Ala Lys Val Val Asp Glu Lys Leu Val Glu Gln Gly Ala 
    210                 215                 220                 


Lys Arg Leu Val Pro Val Gly Met Gly Asp Asp Asp Gln Cys Ile Glu 
225                 230                 235                 240 


Asp Asp Phe Thr Ala Trp Lys Glu Leu Val Trp Pro Glu Leu Asp Gln 
                245                 250                 255     


Leu Leu Arg Asp Glu Asp Asp Thr Ser Val Ala Thr Pro Tyr Thr Ala 
            260                 265                 270         


Ala Val Ala Glu Tyr Arg Val Val Phe His Asp Lys Pro Glu Thr Tyr 
        275                 280                 285             


Asp Gln Asp Gln Leu Thr Asn Gly His Ala Val His Asp Ala Gln His 
    290                 295                 300                 


Pro Cys Arg Ser Asn Val Ala Val Lys Lys Glu Leu His Ser Pro Leu 
305                 310                 315                 320 


Ser Asp Arg Ser Cys Thr His Leu Glu Phe Asp Ile Ser Asn Thr Gly 
                325                 330                 335     


Leu Ser Tyr Glu Thr Gly Asp His Val Gly Val Tyr Val Glu Asn Leu 
            340                 345                 350         


Ser Glu Val Val Asp Glu Ala Glu Lys Leu Ile Gly Leu Pro Pro His 
        355                 360                 365             


Thr Tyr Phe Ser Val His Ala Asp Asn Glu Asp Gly Thr Pro Leu Gly 
    370                 375                 380                 


Gly Ala Ser Leu Pro Pro Pro Phe Pro Pro Cys Thr Leu Arg Lys Ala 
385                 390                 395                 400 


Leu Ala Ser Tyr Ala Asp Val Leu Ser Ser Pro Lys Lys Ser Ala Leu 
                405                 410                 415     


Leu Ala Leu Ala Ala His Ala Thr Asp Ser Thr Glu Ala Asp Arg Leu 
            420                 425                 430         


Lys Phe Leu Ala Ser Pro Ala Gly Lys Asp Glu Tyr Ala Gln Trp Ile 
        435                 440                 445             


Val Ala Ser His Arg Ser Leu Leu Glu Val Met Glu Ala Phe Pro Ser 
    450                 455                 460                 


Ala Lys Pro Pro Leu Gly Val Phe Phe Ala Ser Val Ala Pro Arg Leu 
465                 470                 475                 480 


Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Phe Ala Pro Asn 
                485                 490                 495     


Arg Ile His Val Thr Cys Ala Leu Val Tyr Glu Gln Thr Pro Ser Gly 
            500                 505                 510         


Arg Val His Lys Gly Val Cys Ser Thr Trp Met Lys Asn Ala Val Pro 
        515                 520                 525             


Met Thr Glu Ser Gln Asp Cys Ser Trp Ala Pro Ile Tyr Val Arg Thr 
    530                 535                 540                 


Ser Asn Phe Arg Leu Pro Ser Asp Pro Lys Val Pro Val Ile Met Ile 
545                 550                 555                 560 


Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe Leu Gln Glu Arg 
                565                 570                 575     


Leu Ala Gln Lys Glu Ala Gly Thr Glu Leu Gly Thr Ala Ile Leu Phe 
            580                 585                 590         


Phe Gly Cys Arg Asn Arg Lys Val Asp Phe Ile Tyr Glu Asp Glu Leu 
        595                 600                 605             


Asn Asn Phe Val Glu Thr Gly Ala Leu Ser Glu Leu Val Thr Ala Phe 
    610                 615                 620                 


Ser Arg Glu Gly Ala Thr Lys Glu Tyr Val Gln His Lys Met Thr Gln 
625                 630                 635                 640 


Lys Ala Ser Asp Ile Trp Asn Leu Leu Ser Glu Gly Ala Tyr Leu Tyr 
                645                 650                 655     


Val Cys Gly Asp Ala Lys Gly Met Ala Lys Asp Val His Arg Thr Leu 
            660                 665                 670         


His Thr Ile Val Gln Glu Gln Gly Ser Leu Asp Ser Ser Lys Ala Glu 
        675                 680                 685             


Leu Tyr Val Lys Asn Leu Gln Met Ala Gly Arg Tyr Leu Arg Asp Val 
    690                 695                 700                 


Trp 
705 


<210>  6
<211>  378
<212>  PRT
<213>  Artemisia annua

<400>  6

Met Ala Gln Lys Ala Pro Gly Val Ile Thr Cys Lys Ala Ala Val Val 
1               5                   10                  15      


Trp Glu Ser Ser Gly Pro Val Val Leu Glu Glu Ile Arg Val Asp Pro 
            20                  25                  30          


Pro Lys Ala Ser Glu Val Arg Ile Lys Met Leu Cys Ala Ser Leu Cys 
        35                  40                  45              


His Thr Asp Val Leu Cys Thr Lys Gly Phe Pro Ile Pro Leu Phe Pro 
    50                  55                  60                  


Arg Ile Pro Gly His Glu Gly Val Gly Val Ile Glu Ser Ile Gly Lys 
65                  70                  75                  80  


Asp Ala Lys Gly Leu Lys Pro Gly Asp Ile Val Met Pro Leu Tyr Leu 
                85                  90                  95      


Gly Glu Cys Gly Gln Cys Leu Asn Cys Lys Thr Gly Lys Thr Asn Leu 
            100                 105                 110         


Cys His Val Tyr Pro Pro Ser Phe Ser Gly Leu Met Asn Asp Gly Thr 
        115                 120                 125             


Ser Arg Met Ser Ile Ala Arg Thr Gly Glu Ser Ile Tyr His Phe Ala 
    130                 135                 140                 


Ser Cys Ser Thr Trp Thr Glu Tyr Ala Val Ala Asp Cys Asn Tyr Val 
145                 150                 155                 160 


Leu Lys Ile Asn Pro Lys Ile Ser Tyr Pro His Ala Ser Phe Leu Ser 
                165                 170                 175     


Cys Gly Phe Thr Thr Gly Phe Gly Ala Thr Trp Arg Glu Thr Gln Val 
            180                 185                 190         


Ser Lys Gly Ser Ser Val Ala Val Phe Gly Ile Gly Thr Val Gly Leu 
        195                 200                 205             


Gly Val Ile Lys Gly Ala Gln Leu Gln Gly Ala Ser Lys Ile Ile Gly 
    210                 215                 220                 


Val Asp Val Asn Gln Tyr Lys Ala Ala Lys Gly Lys Val Phe Gly Met 
225                 230                 235                 240 


Thr Asp Phe Ile Asn Pro Lys Asp His Pro Asp Lys Ser Val Ser Glu 
                245                 250                 255     


Leu Val Lys Glu Leu Thr His Gly Leu Gly Val Asp His Cys Phe Glu 
            260                 265                 270         


Cys Thr Gly Val Pro Ser Leu Leu Asn Glu Ala Leu Glu Ala Ser Lys 
        275                 280                 285             


Ile Gly Ile Gly Thr Val Val Pro Ile Gly Ala Gly Gly Glu Ala Ser 
    290                 295                 300                 


Val Ala Ile Asn Ser Leu Ile Leu Phe Ser Gly Arg Thr Leu Lys Phe 
305                 310                 315                 320 


Thr Ala Phe Gly Gly Val Arg Thr Gln Ser Asp Leu Pro Val Ile Ile 
                325                 330                 335     


Asp Lys Cys Leu Asn Lys Glu Ile Gln Leu Asp Glu Leu Leu Thr His 
            340                 345                 350         


Glu Ile His Leu Asp Asn Ile Gln Glu Ala Phe Glu Ile Leu Lys Lys 
        355                 360                 365             


Pro Asp Cys Val Lys Ile Leu Ile Lys Phe 
    370                 375             


<210>  7
<211>  378
<212>  PRT
<213>  Artemisia annua

<400>  7

Met Ala Gln Lys Ala Pro Gly Val Ile Thr Cys Lys Ala Ala Val Val 
1               5                   10                  15      


Trp Glu Ser Ser Gly Pro Val Val Leu Glu Glu Ile Arg Val Asp Pro 
            20                  25                  30          


Pro Lys Ala Ser Glu Val Arg Ile Lys Met Leu Cys Ala Ser Leu Cys 
        35                  40                  45              


His Thr Asp Val Leu Cys Thr Lys Gly Phe Pro Ile Pro Leu Phe Pro 
    50                  55                  60                  


Arg Ile Pro Gly His Glu Gly Val Gly Val Ile Glu Ser Ile Gly Lys 
65                  70                  75                  80  


Asp Val Lys Gly Leu Lys Pro Gly Asp Ile Val Met Pro Leu Tyr Leu 
                85                  90                  95      


Gly Glu Cys Gly Gln Cys Leu Asn Cys Lys Thr Gly Lys Thr Asn Leu 
            100                 105                 110         


Cys His Val Tyr Pro Pro Ser Phe Ser Gly Leu Met Asn Asp Gly Thr 
        115                 120                 125             


Ser Arg Met Ser Ile Ala Arg Thr Gly Glu Ser Ile Tyr His Phe Ala 
    130                 135                 140                 


Ser Cys Ser Thr Trp Thr Glu Tyr Ala Val Ala Asp Cys Asn Tyr Val 
145                 150                 155                 160 


Leu Lys Ile Asn Pro Lys Ile Ser Tyr Pro His Ala Ser Phe Leu Ser 
                165                 170                 175     


Cys Gly Phe Thr Thr Gly Phe Gly Ala Thr Trp Arg Glu Thr Gln Val 
            180                 185                 190         


Ser Lys Gly Ser Ser Val Ala Val Phe Gly Ile Gly Thr Val Gly Leu 
        195                 200                 205             


Gly Val Ile Lys Gly Ala Gln Leu Gln Gly Ala Ser Lys Ile Ile Gly 
    210                 215                 220                 


Val Asp Val Asn Gln Tyr Lys Ala Ala Lys Gly Lys Val Phe Gly Met 
225                 230                 235                 240 


Thr Asp Phe Ile Asn Pro Lys Asp His Pro Asp Lys Ser Val Ser Glu 
                245                 250                 255     


Leu Val Lys Glu Leu Thr His Gly Leu Gly Val Asp His Cys Phe Glu 
            260                 265                 270         


Cys Thr Gly Val Pro Ser Leu Leu Asn Glu Ala Leu Glu Ala Ser Lys 
        275                 280                 285             


Ile Gly Ile Gly Thr Val Val Pro Ile Gly Ala Gly Gly Glu Ala Ser 
    290                 295                 300                 


Val Ala Ile Asn Ser Leu Ile Leu Phe Ser Gly Arg Thr Leu Lys Phe 
305                 310                 315                 320 


Thr Ala Phe Gly Gly Val Arg Thr Gln Ser Asp Leu Pro Val Ile Ile 
                325                 330                 335     


Asp Lys Cys Leu Asn Lys Glu Ile Gln Leu Asp Glu Leu Leu Thr His 
            340                 345                 350         


Glu Ile His Leu Asp Asn Ile Gln Glu Ala Phe Glu Ile Leu Lys Lys 
        355                 360                 365             


Pro Asp Cys Val Lys Ile Leu Ile Lys Phe 
    370                 375             


<210>  8
<211>  500
<212>  PRT
<213>  Artemisia annua

<400>  8

Met Ala Ser Ser Gly Ala Asn Gly Ser Ser Lys Ser Ala Ser His Lys 
1               5                   10                  15      


Ile Lys Phe Thr Lys Leu Phe Ile Asn Gly Glu Phe Val Asp Ser Ile 
            20                  25                  30          


Ser Gly Asn Thr Phe Asp Thr Ile Asn Pro Ala Thr Glu Glu Val Leu 
        35                  40                  45              


Ala Thr Val Ala Glu Gly Arg Lys Glu Asp Ile Asp Leu Ala Val Lys 
    50                  55                  60                  


Ala Ala Arg Glu Ala Phe Asp Asn Gly Pro Trp Pro Arg Met Ser Gly 
65                  70                  75                  80  


Glu Ala Arg Arg Lys Ile Met Leu Lys Phe Ala Asp Leu Ile Asp Glu 
                85                  90                  95      


Asn Ala Asp Glu Leu Thr Thr Leu Glu Val Ile Asp Gly Gly Lys Leu 
            100                 105                 110         


Phe Gly Pro Val Arg His Phe Glu Val Pro Val Ser Ser Asp Thr Phe 
        115                 120                 125             


Arg Tyr Phe Ala Gly Ala Ala Asp Lys Ile Arg Gly Ala Thr Leu Lys 
    130                 135                 140                 


Met Ser Ser Asn Ile Gln Ala Tyr Thr Leu Arg Glu Pro Ile Gly Val 
145                 150                 155                 160 


Val Gly His Ile Ile Pro Trp Asn Gly Pro Ala Phe Met Phe Ala Thr 
                165                 170                 175     


Lys Val Ala Pro Ala Leu Ala Ala Gly Cys Thr Met Val Ile Lys Pro 
            180                 185                 190         


Ala Glu His Thr Pro Leu Thr Val Leu Phe Leu Ala His Leu Ser Lys 
        195                 200                 205             


Leu Ala Gly Val Pro Asp Gly Val Ile Asn Val Val Asn Gly Phe Gly 
    210                 215                 220                 


Lys Thr Ala Gly Ala Ala Val Ser Ser His Met Asp Ile Asp Met Val 
225                 230                 235                 240 


Thr Phe Thr Gly Ser Thr Glu Val Gly Arg Thr Val Met Gln Ala Ala 
                245                 250                 255     


Ala Leu Ser Asn Leu Lys Pro Val Ser Leu Glu Leu Gly Gly Lys Ser 
            260                 265                 270         


Pro Leu Ile Val Phe Asp Asp Ala Asp Val Asp Lys Ala Ala Glu Phe 
        275                 280                 285             


Ala Ile Leu Gly Asn Phe Thr Asn Lys Gly Glu Met Cys Val Ala Gly 
    290                 295                 300                 


Ser Arg Val Phe Val Gln Glu Gly Ile His Asp Val Phe Val Lys Lys 
305                 310                 315                 320 


Leu Glu Gly Ala Val Lys Ala Trp Ala Thr Arg Asp Pro Phe Asp Leu 
                325                 330                 335     


Ala Thr Arg His Gly Pro Gln Asn Asn Lys Gln Gln Tyr Asp Lys Val 
            340                 345                 350         


Leu Ser Cys Ile Asn His Gly Lys Lys Glu Gly Ala Thr Leu Val Thr 
        355                 360                 365             


Gly Gly Lys Pro Phe Gly Lys Lys Gly Tyr Tyr Ile Glu Pro Thr Leu 
    370                 375                 380                 


Phe Thr Asn Val Thr Asp Asp Met Thr Ile Ala Lys Glu Glu Ile Phe 
385                 390                 395                 400 


Gly Pro Val Ile Ser Val Leu Lys Phe Lys Thr Val Glu Glu Val Ile 
                405                 410                 415     


Lys Arg Ala Asn Ala Thr Lys Tyr Gly Leu Ala Ser Gly Val Phe Thr 
            420                 425                 430         


Lys Asn Ile Asp Val Val Asn Thr Val Ser Arg Ser Ile Arg Ala Gly 
        435                 440                 445             


Ala Val Trp Val Asn Cys Tyr Leu Ala Leu Asp Arg Asp Ala Pro His 
    450                 455                 460                 


Gly Gly Tyr Lys Met Ser Gly Phe Gly Arg Glu Gln Gly Leu Glu Ala 
465                 470                 475                 480 


Leu Glu His Tyr Leu Gln Ile Lys Thr Val Ala Thr Pro Ile Tyr Asp 
                485                 490                 495     


Ser Pro Trp Leu 
            500 


<210>  9
<211>  388
<212>  PRT
<213>  Artemisia annua

<400>  9

Met Ala Ser Glu Lys Pro Thr Leu Phe Ser Ala Tyr Lys Met Gly Lys 
1               5                   10                  15      


Phe Asn Leu Ser His Arg Val Val Leu Ala Pro Met Thr Arg Cys Arg 
            20                  25                  30          


Ala Ile Asn Ala Ile Pro Asn Glu Ala Leu Val Glu Tyr Tyr Arg Gln 
        35                  40                  45              


Arg Ser Thr Ala Gly Gly Phe Leu Ile Thr Glu Gly Thr Met Ile Ser 
    50                  55                  60                  


Pro Ser Ser Ala Gly Phe Pro His Val Pro Gly Ile Phe Thr Lys Glu 
65                  70                  75                  80  


Gln Val Glu Gly Trp Lys Lys Val Val Asp Ala Ala His Lys Glu Gly 
                85                  90                  95      


Ala Val Ile Phe Cys Gln Leu Trp His Val Gly Arg Ala Ser His Gln 
            100                 105                 110         


Val Tyr Gln Pro Gly Gly Ala Ala Pro Ile Ser Ser Thr Ser Lys Pro 
        115                 120                 125             


Ile Ser Lys Lys Trp Glu Ile Leu Leu Pro Asp Ala Thr Tyr Gly Thr 
    130                 135                 140                 


Tyr Pro Glu Pro Arg Pro Leu Ala Ala Asn Glu Ile Leu Glu Val Val 
145                 150                 155                 160 


Glu Asp Tyr Arg Val Ala Ala Ile Asn Ala Ile Glu Ala Gly Phe Asp 
                165                 170                 175     


Gly Ile Glu Ile His Gly Ala His Gly Tyr Leu Leu Asp Gln Phe Met 
            180                 185                 190         


Lys Asp Gly Ile Asn Asp Arg Thr Asp Glu Tyr Gly Gly Ser Leu Glu 
        195                 200                 205             


Asn Arg Cys Lys Phe Ile Leu Gln Val Val Gln Ala Val Ser Ala Ala 
    210                 215                 220                 


Ile Gly Thr Asp Arg Val Gly Ile Arg Ile Ser Pro Ala Ile Asp His 
225                 230                 235                 240 


Thr Asp Ala Met Asp Ser Asp Pro Arg Ser Leu Gly Leu Ala Val Ile 
                245                 250                 255     


Glu Arg Leu Asn Lys Leu Gln Phe Lys Leu Gly Ser Arg Leu Ala Tyr 
            260                 265                 270         


Leu His Val Thr Gln Pro Arg Tyr Thr Ala Asp Gly His Gly Gln Thr 
        275                 280                 285             


Glu Ala Gly Ala Asn Gly Ser Glu Glu Glu Val Ala Gln Leu Met Lys 
    290                 295                 300                 


Thr Trp Arg Gly Ala Tyr Val Gly Thr Phe Ile Cys Cys Gly Gly Tyr 
305                 310                 315                 320 


Thr Arg Glu Leu Gly Leu Gln Ala Val Ala Gln Gly Asp Ala Asp Leu 
                325                 330                 335     


Val Ala Phe Gly Arg Tyr Phe Val Ser Asn Pro Asp Leu Val Leu Arg 
            340                 345                 350         


Leu Lys Leu Asn Ala Pro Leu Asn Arg Tyr Asp Arg Ala Thr Phe Tyr 
        355                 360                 365             


Thr His Asp Pro Val Val Gly Tyr Thr Asp Tyr Pro Ser Leu Asp Lys 
    370                 375                 380                 


Gly Ser Leu Leu 
385             


<210>  10
<211>  392
<212>  PRT
<213>  Artemisia annua

<400>  10

Met Ser Glu Lys Pro Thr Leu Phe Ser Pro Tyr Lys Met Gly Asn Phe 
1               5                   10                  15      


Asn Leu Ser His Arg Val Val Leu Ala Pro Met Thr Arg Cys Arg Ala 
            20                  25                  30          


Ile Asn Ala Ile Pro Asn Glu Ala Leu Val Glu Tyr Tyr Gln Gln Arg 
        35                  40                  45              


Ser Thr Ala Gly Gly Phe Leu Ile Thr Glu Gly Thr Met Ile Ser Pro 
    50                  55                  60                  


Ser Ser Ala Gly Phe Pro His Val Pro Gly Ile Phe Thr Lys Glu Gln 
65                  70                  75                  80  


Val Glu Gly Trp Lys Lys Val Val Asp Ala Ala His Lys Glu Gly Ala 
                85                  90                  95      


Val Ile Phe Cys Gln Leu Trp His Val Gly Arg Ala Ser His Gln Val 
            100                 105                 110         


Tyr Gln Pro Gly Gly Ala Ala Pro Ile Ser Ser Thr Ser Lys Pro Ile 
        115                 120                 125             


Ser Lys Lys Trp Lys Ile Leu Met Pro Asp Ala Thr Tyr Gly Thr Tyr 
    130                 135                 140                 


Pro Glu Pro Arg Pro Leu Ala Ala Asn Glu Ile Leu Glu Val Val Glu 
145                 150                 155                 160 


Asp Tyr Arg Ile Ala Ala Ile Asn Ala Ile Glu Ala Gly Phe Asp Gly 
                165                 170                 175     


Ile Glu Ile His Gly Ala His Gly Tyr Leu Leu Asp Gln Phe Met Lys 
            180                 185                 190         


Asp Gly Ile Asn Asp Arg Thr Asp Glu Tyr Gly Gly Ser Leu Glu Asn 
        195                 200                 205             


Arg Cys Lys Phe Ile Leu Gln Val Val Gln Ala Val Ser Ala Ala Ile 
    210                 215                 220                 


Gly Ala Asp Arg Val Gly Leu Arg Ile Ser Pro Ala Ile Asp His Leu 
225                 230                 235                 240 


Asp Ala Met Asp Ser Asp Pro Arg Ser Leu Gly Leu Ala Val Ile Glu 
                245                 250                 255     


Arg Leu Asn Lys Leu Gln Phe Lys Leu Gly Ser Arg Leu Ala Tyr Leu 
            260                 265                 270         


His Val Thr Gln Pro Arg Tyr Thr Ala Tyr Gly Gln Thr Glu Ala Gly 
        275                 280                 285             


Ala His Gly Ser Glu Glu Glu Val Ala Gln Leu Met Lys Ala Trp Arg 
    290                 295                 300                 


Gly Ala Tyr Val Gly Thr Phe Ile Cys Ser Gly Gly Tyr Thr Arg Glu 
305                 310                 315                 320 


Leu Gly Leu Gln Ala Val Ala Gln Gly Asp Ala Asp Leu Val Ala Phe 
                325                 330                 335     


Gly Arg His Phe Ile Ser Asn Pro Asp Leu Val Leu Arg Leu Lys Leu 
            340                 345                 350         


Asn Ala Pro Leu Asn Arg Tyr Val Arg Ala Thr Phe Tyr Thr His Asp 
        355                 360                 365             


Pro Val Val Gly Tyr Thr Asp Tyr Pro Ser Leu Asp Lys Gly Asn Val 
    370                 375                 380                 


Gly Val Glu Arg Leu Ser Arg Leu 
385                 390         


<210>  11
<211>  328
<212>  PRT
<213>  Artemisia annua

<400>  11

Met Gly Arg Ile Ile Val Phe Gln Val Leu Ala Leu Cys Ser Leu Leu 
1               5                   10                  15      


Val Phe Pro Asn Ile Ala Phe Ala Gln Leu Lys Gln Asn Tyr Tyr Ala 
            20                  25                  30          


Asn Ile Cys Pro Asn Val Glu Ser Ile Val Gln Lys Ala Val Ala Ala 
        35                  40                  45              


Lys Val Lys Gln Thr Phe Val Thr Ile Pro Gly Thr Leu Arg Leu Phe 
    50                  55                  60                  


Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser Val Met Ile Gln 
65                  70                  75                  80  


Ser Ser Gly Ser Asn Thr Ala Glu Lys Asp His Pro Asp Asn Leu Ser 
                85                  90                  95      


Leu Ala Gly Asp Gly Phe Asp Thr Val Ile Lys Ala Lys Ala Ala Val 
            100                 105                 110         


Asp Ala Asn Pro Ser Cys Arg Asn Lys Val Ser Cys Ala Asp Ile Leu 
        115                 120                 125             


Thr Met Ala Thr Arg Asp Val Val Lys Ile Ala Gly Gly Pro Ser Tyr 
    130                 135                 140                 


Ser Val Glu Leu Gly Arg Leu Asp Gly Leu Ser Ser Thr Ala Ala Ser 
145                 150                 155                 160 


Val Gly Gly Asn Leu Pro Lys Pro Asn Gln Asn Leu Asp Gln Leu Asn 
                165                 170                 175     


Ala Leu Phe Ala Ala Asn Gly Leu Thr Gln Ala Asp Met Ile Ala Leu 
            180                 185                 190         


Ser Gly Ala His Thr Leu Gly Phe Ser His Cys Asn Gln Phe Ser Asn 
        195                 200                 205             


Arg Ile Tyr Asn Phe Ser Lys Gln Asn Pro Val Asp Pro Thr Leu Asn 
    210                 215                 220                 


Pro Ser Tyr Ala Thr Gln Leu Gln Gln Gln Cys Pro Lys Asn Val Asp 
225                 230                 235                 240 


Pro Arg Ile Ala Ile Asn Met Asp Pro Asn Thr Pro Arg Thr Phe Asp 
                245                 250                 255     


Asn Val Tyr Tyr Lys Asn Leu Gln Asn Gly Gln Gly Leu Phe Thr Ser 
            260                 265                 270         


Asp Gln Val Leu Phe Thr Asp Thr Arg Ser Lys Gln Thr Val Ile Ser 
        275                 280                 285             


Trp Ala Asn Ser Pro Thr Ala Phe Asn Asn Ala Phe Ile Thr Ala Met 
    290                 295                 300                 


Thr Lys Leu Gly Arg Val Gly Val Lys Thr Gly Thr Lys Gly Asn Ile 
305                 310                 315                 320 


Arg Lys Asp Cys Ala Ala Phe Asn 
                325             


<210>  12
<211>  328
<212>  PRT
<213>  Artemisia annua

<400>  12

Met Ser Arg Phe Ile Phe Ile Gln Val Leu Ala Phe Leu Ser Leu Leu 
1               5                   10                  15      


Ile Phe Pro Asn Ile Ala Phe Ala Glu Leu Lys Gln Asn Tyr Tyr Ala 
            20                  25                  30          


Asn Ile Cys Pro Asp Val Glu Thr Ile Val Arg Lys Ala Val Ala Ala 
        35                  40                  45              


Lys Leu Ala Glu Thr Pro Ile Thr Val Gln Gly Thr Leu Arg Leu Leu 
    50                  55                  60                  


Phe His Asp Cys Phe Val Glu Gly Cys Asp Ala Ser Ile Met Ile Gln 
65                  70                  75                  80  


Ser Ser Gly Ser Asn Thr Ala Glu Lys Asp His Pro Glu Asn Leu Ser 
                85                  90                  95      


Leu Ala Gly Asp Gly Phe Asp Thr Val Met Lys Ala Lys Ala Ala Val 
            100                 105                 110         


Asp Ala Val Pro Ser Cys Lys Asn Lys Val Ser Cys Ala Asp Ile Leu 
        115                 120                 125             


Thr Met Ala Ala Arg Asp Val Val Gln Met Ala Gly Gly Pro Ser Tyr 
    130                 135                 140                 


Pro Val Glu Leu Gly Arg Leu Asp Gly Leu Ser Ser Thr Ala Ala Ser 
145                 150                 155                 160 


Val Asn Gly Arg Leu Pro Lys Ala Asn Gln Asn Leu Asp Gln Leu Asn 
                165                 170                 175     


Ala Ile Phe Ala Ala Asn Gly Leu Asn Gln Thr Glu Met Ile Ala Leu 
            180                 185                 190         


Ser Gly Ala His Thr Leu Gly Phe Ser His Cys Asp Gln Phe Leu Asn 
        195                 200                 205             


Arg Ile Tyr Asn Phe Ser Lys Gln Asn Pro Val Asp Pro Thr Leu Ile 
    210                 215                 220                 


Pro Ser Tyr Ala Ala Glu Leu Gln Gln Arg Cys Pro Lys Asn Phe Asp 
225                 230                 235                 240 


Pro Asp Thr Val Ile Asp Leu Asp Pro Ser Thr Thr Gly Ile Phe Asp 
                245                 250                 255     


Asn Met Tyr Tyr Lys Asn Leu Gln Asn Gly Gln Gly Leu Leu Thr Ser 
            260                 265                 270         


Asp Gln Val Leu Phe Thr Asp Met Arg Ser Lys Gln Thr Val Ile Ser 
        275                 280                 285             


Trp Ala Asn Ser Pro Lys Asp Phe Ser Asp Ala Phe Val Lys Ala Met 
    290                 295                 300                 


Thr Lys Leu Gly Arg Val Gly Val Lys Thr Gly Lys Asn Gly Asn Ile 
305                 310                 315                 320 


Arg Arg Asp Cys Ser Ala Phe Asn 
                325             


<210>  13
<211>  307
<212>  PRT
<213>  Artemisia annua

<400>  13

Met Ser Arg Phe Ile Phe Ile Gln Val Leu Ala Phe Leu Ser Leu Leu 
1               5                   10                  15      


Ile Phe Pro Asn Ile Ala Phe Ala Glu Leu Lys Gln Asn Tyr Tyr Ala 
            20                  25                  30          


Asn Ile Cys Pro Asp Val Glu Thr Ile Val Arg Lys Ala Val Ala Ala 
        35                  40                  45              


Lys Leu Ala Glu Thr Pro Ile Thr Val Gln Gly Thr Leu Arg Leu Leu 
    50                  55                  60                  


Phe His Asp Cys Phe Val Glu Gly Cys Asp Ala Ser Ile Met Ile Gln 
65                  70                  75                  80  


Ser Ser Gly Ser Asn Thr Ala Glu Lys Asp His Pro Glu Asn Leu Ser 
                85                  90                  95      


Leu Ala Gly Asp Gly Phe Asp Thr Val Met Lys Ala Lys Ala Ala Val 
            100                 105                 110         


Asp Ala Val Pro Ser Cys Lys Asn Lys Val Ser Cys Ala Asp Ile Leu 
        115                 120                 125             


Thr Met Ala Ala Arg Asp Val Val Gln Met Ala Gly Gly Pro Ser Tyr 
    130                 135                 140                 


Pro Val Glu Leu Gly Arg Leu Asp Gly Leu Ser Ser Thr Ala Ala Ser 
145                 150                 155                 160 


Val Asn Gly Lys Leu Pro Lys Ala Asn Gln Asn Leu Asp Gln Leu Asn 
                165                 170                 175     


Ala Ile Phe Ala Ala Asn Gly Leu Asn Gln Thr Glu Met Ile Ala Leu 
            180                 185                 190         


Ser Gly Ala His Thr Leu Gly Phe Ser His Cys Asp Gln Phe Leu Asn 
        195                 200                 205             


Arg Ile Tyr Asn Phe Ser Lys Glu Asn Pro Val Asp Pro Thr Leu Ile 
    210                 215                 220                 


Pro Ser Tyr Ala Ala Glu Leu Gln Gln Gln Cys Pro Lys Lys Asn Phe 
225                 230                 235                 240 


Asp Pro Asn Asn Gly Gln Gly Leu Leu Ala Ser Asp Gln Val Leu Phe 
                245                 250                 255     


Thr Asp Thr Arg Ser Lys Gln Thr Val Ile Ser Trp Ala Asn Ser Pro 
            260                 265                 270         


Lys Asp Phe Ser Asn Ala Phe Val Lys Ala Met Thr Lys Leu Gly Arg 
        275                 280                 285             


Val Gly Val Lys Thr Gly Gln Asn Gly Asn Ile Arg Arg Asp Cys Ser 
    290                 295                 300                 


Ala Phe Asn 
305         


<210>  14
<211>  318
<212>  PRT
<213>  Artemisia annua

<400>  14

Met Lys Lys Gln Ile Leu Cys Leu Leu Phe Leu Ser Leu Phe Ile Ala 
1               5                   10                  15      


Pro Ser Tyr Ala Gln Leu Arg Gln Lys Phe Tyr Gln Asn Thr Cys Pro 
            20                  25                  30          


Asn Val Glu Ser Ile Val Thr Ala Ala Val Thr Lys Lys Phe Gln Gln 
        35                  40                  45              


Thr Phe Val Thr Ile Pro Gly Thr Leu Arg Leu Phe Phe His Asp Cys 
    50                  55                  60                  


Phe Val Arg Gly Cys Asp Ala Ser Val Ile Leu Ala Asn Pro Asn Ser 
65                  70                  75                  80  


Glu Lys Asp His Pro Asp Asp Gln Ser Leu Ala Gly Asp Gly Phe Asp 
                85                  90                  95      


Thr Val Ile Lys Ala Lys Ala Ala Val Asp Ser Asn Pro Ser Cys Arg 
            100                 105                 110         


Asn Lys Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Thr Arg Asp Val 
        115                 120                 125             


Ile Arg Leu Ala Gly Gly Pro Phe Tyr Ser Val Glu Leu Gly Arg Arg 
    130                 135                 140                 


Asp Gly Arg Ile Ser Thr Thr Ala Ser Val Thr Asn Asn Leu Pro His 
145                 150                 155                 160 


Pro Glu Phe Lys Leu Asp Gln Leu Asn Ser Met Phe Ala Lys Asn Gly 
                165                 170                 175     


Leu Ser Gln Thr Asp Met Ile Ala Leu Ser Gly Ala His Thr Leu Gly 
            180                 185                 190         


Phe Ser His Cys Ser Lys Phe Ala Ser Arg Ile Tyr Ser Arg Asn Gly 
        195                 200                 205             


Ile Asp Pro Thr Leu Asn Arg Gln Tyr Ala Thr Gln Leu Gln Gln Met 
    210                 215                 220                 


Cys Pro Gln Asn Val Asp Pro Asn Ile Ala Ile Asn Met Asp Pro Thr 
225                 230                 235                 240 


Thr Pro Arg Thr Phe Asp Asn Val Tyr Tyr Lys Asn Leu Gln Gln Gly 
                245                 250                 255     


Lys Gly Leu Phe Val Ser Asp Gln Ile Leu Phe Thr Asp Ser Arg Ser 
            260                 265                 270         


Arg Ala Thr Val Asn Leu Phe Ala Ser Asn Ser Thr Ala Phe Asn Lys 
        275                 280                 285             


Ala Phe Val Ala Ala Met Thr Lys Leu Gly Arg Val Gly Val Leu Thr 
    290                 295                 300                 


Gly Asn Leu Gly Glu Ile Arg Arg Asp Cys Ala Arg Val Asn 
305                 310                 315             


<210>  15
<211>  319
<212>  PRT
<213>  Artemisia annua

<400>  15

Met Lys Lys Gln Val Leu Cys Leu Leu Phe Leu Ser Phe Phe Val Ala 
1               5                   10                  15      


Ser Ser Tyr Ala Gln Leu Arg Gln Asn Phe Tyr Gln Asn Thr Cys Pro 
            20                  25                  30          


Asn Val Glu Ser Ile Val Arg Ser Ala Val Ala Lys Lys Phe Gln Gln 
        35                  40                  45              


Thr Phe Val Thr Ala Pro Gly Thr Leu Arg Leu Phe Phe His Asp Cys 
    50                  55                  60                  


Phe Val Arg Gly Cys Asp Ala Ser Ile Phe Leu Ser Asn Asn Leu Asn 
65                  70                  75                  80  


Ala Glu Lys Asp His Pro Asp Asp Gln Ser Leu Ala Gly Asp Gly Phe 
                85                  90                  95      


Asp Thr Val Ile Gln Ala Lys Ala Ala Leu Asp Ser Asn Pro Asn Cys 
            100                 105                 110         


Arg Asn Lys Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Thr Arg Asp 
        115                 120                 125             


Val Val Ala Leu Thr Gly Gly Pro Ser Tyr Lys Val Glu Leu Gly Arg 
    130                 135                 140                 


Arg Asp Gly Arg Ile Ser Thr Lys Ala Ser Val Gln His Lys Leu Pro 
145                 150                 155                 160 


His Ala Asp Phe Asn Leu Asp Lys Leu Asn Thr Met Phe Ala Ala His 
                165                 170                 175     


Gly Leu Ser Gln Thr Asp Met Ile Ala Leu Ser Gly Ala His Thr Leu 
            180                 185                 190         


Gly Phe Ser His Cys Gly Gln Phe Ser Arg Arg Ile Tyr Ser Lys Ala 
        195                 200                 205             


Gly Ile Asp Lys Thr Leu Asn Arg Asn Tyr Ala Leu Gln Leu Arg Gln 
    210                 215                 220                 


Met Cys Pro Leu Lys Val Asp Pro Arg Ile Ala Ile Asn Met Asp Pro 
225                 230                 235                 240 


Thr Thr Pro Arg Thr Phe Asp Asn Thr Tyr Tyr Lys Asn Leu Gln Gln 
                245                 250                 255     


Gly Met Gly Leu Phe Ser Ser Asp Gln Ile Leu Phe Thr Asp Gln Arg 
            260                 265                 270         


Ser Arg Pro Thr Val Asn Leu Phe Ala Ser Asn Asn Asn Ala Phe Asn 
        275                 280                 285             


Gln Ala Phe Val Asn Ala Met Thr Lys Leu Gly Arg Val Gly Val Leu 
    290                 295                 300                 


Thr Gly Asn Gln Gly Glu Ile Arg Arg Asp Cys Asn Arg Val Asn 
305                 310                 315                 


<210>  16
<211>  319
<212>  PRT
<213>  Artemisia annua

<400>  16

Met Lys Lys Gln Val Leu Cys Leu Leu Phe Leu Ser Phe Phe Val Ala 
1               5                   10                  15      


Ser Ser Tyr Ala Gln Leu Arg Gln Asn Phe Tyr Gln Asn Thr Cys Pro 
            20                  25                  30          


Asn Val Glu Ser Ile Val Arg Ser Ala Val Ser Lys Lys Phe Gln Gln 
        35                  40                  45              


Thr Phe Val Thr Ala Pro Gly Thr Leu Arg Leu Phe Phe His Asp Cys 
    50                  55                  60                  


Phe Val Arg Gly Cys Asp Ala Ser Ile Phe Leu Ser Asn Asn Leu Asn 
65                  70                  75                  80  


Ala Glu Lys Asp His His Asp Asp Gln Ser Leu Ala Gly Asp Gly Phe 
                85                  90                  95      


Asp Thr Val Ile Gln Ala Lys Ala Ala Leu Asp Ser Asn Pro Asn Cys 
            100                 105                 110         


Arg Asn Lys Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Thr Arg Asp 
        115                 120                 125             


Val Val Ala Leu Thr Gly Gly Pro Ser Tyr Lys Val Glu Leu Gly Arg 
    130                 135                 140                 


Arg Asp Gly Arg Ile Ser Thr Lys Ala Ser Val Gln His Lys Leu Pro 
145                 150                 155                 160 


His Ala Asp Phe Asn Leu Asp Lys Leu Asn Thr Met Phe Ala Ala His 
                165                 170                 175     


Gly Leu Ser Gln Thr Asp Met Ile Ala Leu Ser Gly Ala His Thr Leu 
            180                 185                 190         


Gly Phe Ser His Cys Gly Gln Phe Ser Arg Arg Ile Tyr Ser Lys Ala 
        195                 200                 205             


Gly Ile Asp Lys Thr Leu Asn Arg Asn Tyr Ala Leu Gln Leu Arg Gln 
    210                 215                 220                 


Met Cys Pro Val Asn Val Asp Pro Arg Ile Ala Ile Asn Met Asp Pro 
225                 230                 235                 240 


Thr Thr Pro Arg Thr Phe Asp Asn Ala Tyr Tyr Lys Asn Leu Gln Lys 
                245                 250                 255     


Gly Met Gly Leu Phe Ser Ser Asp Gln Val Leu Phe Thr Asp Gln Arg 
            260                 265                 270         


Ser Arg Pro Thr Val Asn Leu Phe Ala Ser Asn Asn Asn Ala Phe Asn 
        275                 280                 285             


Gln Ala Phe Val Asn Ala Ile Thr Lys Leu Gly Arg Val Gly Val Leu 
    290                 295                 300                 


Thr Gly Asn Gln Gly Glu Ile Arg Arg Asp Cys Asn Arg Val Asn 
305                 310                 315                 


<210>  17
<211>  334
<212>  PRT
<213>  Artemisia annua

<400>  17

Met Val Met Lys Ala Lys Ala Ala Val Asp Ala Val Ser Ser Cys Lys 
1               5                   10                  15      


Asn Lys Val Ser Cys Ala Asp Ile Leu Thr Met Ala Ala Arg Asp Val 
            20                  25                  30          


Val Gln Met Pro Glu Asn Ala Asn Cys Tyr Lys Asn Pro Val Asp Pro 
        35                  40                  45              


Thr Leu Ile Pro Ser Tyr Ala Ala Glu Leu Gln Gln Gln Cys Pro Lys 
    50                  55                  60                  


Asn Phe Asp Pro Asn Thr Val Ile Ala Leu Gly Pro Ser Thr Thr Gly 
65                  70                  75                  80  


Ile Phe Asp Asn Met Tyr Tyr Lys Asn Leu Gln Asn Gly Gln Gly Leu 
                85                  90                  95      


Leu Thr Ser Asp Gln Gly Cys Asp Ala Ser Ile Met Ile Gln Ser Ser 
            100                 105                 110         


Gly Ser Asn Thr Ala Glu Lys Asp His Gln Asp Asn Leu Ser Leu Ala 
        115                 120                 125             


Gly Asp Gly Phe Asp Met Val Asn Lys Ala Lys Ala Ala Ala Asp Ala 
    130                 135                 140                 


Val Pro Ser Cys Arg Asn Lys Val Ser Cys Ala Asp Ile Leu Thr Met 
145                 150                 155                 160 


Ala Thr Arg Asp Val Ile Lys Met Ala Gly Gly Pro Ser Tyr Pro Val 
                165                 170                 175     


Glu Leu Gly Arg Leu Asp Gly Leu Ser Ser Thr Ala Ala Ser Val Asn 
            180                 185                 190         


Gly Lys Leu Pro Ile Pro Asn Trp Asn Leu Asp Gln Leu Asn Asp Met 
        195                 200                 205             


Phe Ala Phe Asn Gly Leu Thr Gln Ile Asp Met Ile Ala Leu Ser Gly 
    210                 215                 220                 


Ala His Thr Leu Gly Phe Ser His Cys Asp Gln Phe Ala Asn Arg Ile 
225                 230                 235                 240 


Tyr Asn Phe Ser Lys Gln Asn Pro Leu Asp Pro Thr Leu Asn Pro Ser 
                245                 250                 255     


Tyr Ala Thr Gln Leu Gln Gln Leu Cys Pro Lys Asp Ile Thr Pro Leu 
            260                 265                 270         


Val Ala Ile His Met Asp Pro Asn Thr Pro Thr Thr Phe Asp Met Tyr 
        275                 280                 285             


Phe Lys Asn Leu Gln Gln Gly Gln Gly Leu Phe Thr Ser Asp Gln Val 
    290                 295                 300                 


Leu Tyr Thr Asp Thr Arg Ser Lys Gln Thr Met Ile Ser Trp Ala Asn 
305                 310                 315                 320 


Asp Pro Lys Ala Phe Asn Asp Ala Phe Ile Glu Ala Met Thr 
                325                 330                 


<210>  18
<211>  317
<212>  PRT
<213>  Artemisia annua

<400>  18

Met Lys Val Leu Cys Trp Trp Leu Met Val Leu Val Leu Ala Gly Arg 
1               5                   10                  15      


Gly Asn Gly Gln Leu Val Glu Asn Phe Tyr Ala Ala Thr Cys Pro Met 
            20                  25                  30          


Ala Glu Ala Val Val Lys Gln Ala Val Asp Ala Lys Val Ser Gln Thr 
        35                  40                  45              


Phe Thr Thr Ile Pro Ala Thr Leu Arg Leu Phe Phe His Asp Cys Phe 
    50                  55                  60                  


Val Glu Gly Cys Asp Ala Ser Val Met Ile Gln Ser Pro Asn Gly Asp 
65                  70                  75                  80  


Ala Glu Lys Asp Ser Ser Asp Asn Leu Ser Leu Ala Gly Asp Gly Phe 
                85                  90                  95      


Asp Thr Val Ile Lys Ala Lys Glu Ala Val Glu Ser Phe Cys Pro Gly 
            100                 105                 110         


Val Val Ser Cys Ala Asp Val Leu Ala Leu Ala Ala Arg Asp Val Val 
        115                 120                 125             


Val Ala Ala Gly Gly Pro Met Phe Asn Val Gln Leu Gly Arg Arg Asp 
    130                 135                 140                 


Gly Leu Val Ser Lys Ala Ser Arg Val Ala Gly Asn Leu Pro Glu Pro 
145                 150                 155                 160 


Thr Phe Asn Arg Ile Gln Leu Asn Thr Met Phe Ala Arg Asn Asn Leu 
                165                 170                 175     


Ser Glu Leu Asp Met Ile Ala Leu Ser Gly Ala His Thr Leu Gly Phe 
            180                 185                 190         


Ser His Cys Asn Arg Phe Ala Asp Arg Leu Tyr Ser Ser Ser Val Val 
        195                 200                 205             


Asp Pro Ser Leu Asp Pro Thr Tyr Ala Gln Gln Leu Met Ala Ala Cys 
    210                 215                 220                 


Pro Gln Asn Val Asp Pro Asp Ile Ala Ile Asp Met Asp Pro Glu Thr 
225                 230                 235                 240 


Pro His Thr Phe Asp Asn Val Tyr Tyr Gln Asn Leu Val Ala Gly Lys 
                245                 250                 255     


Gly Leu Phe Thr Ser Asp Gln Val Leu Phe Thr Asp Thr Ser Ser Gln 
            260                 265                 270         


Pro Ile Val Asn Asp Phe Ala Asn Ser Ala Gly Asp Phe Asn Ala Ala 
        275                 280                 285             


Phe Ile Thr Ala Met Arg Lys Leu Gly Thr Thr Gly Val Lys Val Gly 
    290                 295                 300                 


Asn Gln Gly Glu Ile Arg Arg Asp Cys Thr Ala Phe Asn 
305                 310                 315         


<210>  19
<211>  289
<212>  PRT
<213>  Artemisia annua

<400>  19

Met Lys Lys His Val Leu Cys Leu Leu Phe Leu Ser Phe Phe Val Ala 
1               5                   10                  15      


Ser Ser Tyr Ala Gln Leu Arg Gln Asn Phe Tyr Gln Asn Thr Cys Pro 
            20                  25                  30          


Asn Val Glu Ser Ile Val Arg Ser Ala Val Ala Lys Lys Phe Gln Gln 
        35                  40                  45              


Thr Phe Val Thr Ala Pro Gly Thr Leu Arg Leu Phe Phe His Asp Cys 
    50                  55                  60                  


Phe Val Arg Gly Cys Asp Ala Ser Ile Phe Leu Ser Asn Asn Leu Asn 
65                  70                  75                  80  


Ala Glu Lys Asp His His Asp Asp Gln Ser Leu Ala Gly Asp Gly Phe 
                85                  90                  95      


Asp Thr Val Ile Gln Ala Lys Ala Ala Leu Asp Ser Asn Pro Asn Cys 
            100                 105                 110         


Arg Asn Lys Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Thr Arg Asp 
        115                 120                 125             


Val Val Ala Leu Thr Gly Gly Pro Ser Tyr Lys Val Glu Leu Gly Arg 
    130                 135                 140                 


Arg Asp Gly Arg Ile Ser Thr Lys Ala Ser Val Gln His Lys Leu Pro 
145                 150                 155                 160 


His Ala Asp Phe Asn Leu Asp Lys Leu Asn Thr Met Phe Ala Ala His 
                165                 170                 175     


Gly Leu Ser Gln Thr Asp Met Ile Ala Leu Ser Gly Ala His Thr Leu 
            180                 185                 190         


Gly Phe Ser His Cys Gly Gln Phe Ser Arg Arg Ile Tyr Ser Lys Ala 
        195                 200                 205             


Gly Ile Asp Lys Thr Leu Asn Arg Asn Tyr Ala Leu Gln Leu Arg Gln 
    210                 215                 220                 


Met Cys Pro Val Asn Val Asp Pro Arg Ile Ala Ile Asn Met Asp Pro 
225                 230                 235                 240 


Thr Thr Pro Arg Asn Phe Asp Asn Ala Tyr Tyr Lys Asn Leu Gln Gln 
                245                 250                 255     


Trp Asp Gly Ala Phe Val Asn Ala Ile Thr Lys Leu Gly Arg Val Gly 
            260                 265                 270         


Val Leu Thr Gly Asn Gln Gly Glu Ile Arg Arg Asp Cys Asn Arg Val 
        275                 280                 285             


Asn 
    


<210>  20
<211>  327
<212>  PRT
<213>  Artemisia annua

<400>  20

Met Ser Ser Lys Pro Leu Ile Leu Ile Leu Phe Ile Ser Leu Leu Ser 
1               5                   10                  15      


Ser Ile Ser Ser Ser Tyr Pro Gln Pro Leu Thr Thr Thr Phe Tyr Gln 
            20                  25                  30          


Lys Thr Cys Pro Arg Phe Asp Gln Ile Met Gln Asp Thr Thr Thr Asn 
        35                  40                  45              


Lys Gln Ile Ala Ser Pro Thr Thr Ala Gly Ala Ala Leu Arg Leu Phe 
    50                  55                  60                  


Phe His Asp Cys Leu Val Glu Gly Cys Asp Ala Ser Val Leu Ile Ser 
65                  70                  75                  80  


Ser Thr His Phe Asn Lys Ala Glu Arg Asp Ala Asp Ile Asn Leu Ser 
                85                  90                  95      


Leu Pro Gly Asp Gly Phe Asp Val Val Val Arg Ala Lys Thr Ala Leu 
            100                 105                 110         


Glu Leu Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Val 
        115                 120                 125             


Ala Thr Arg Asn Leu Val Thr Met Met Gly Gly Pro Phe Tyr Gln Val 
    130                 135                 140                 


Lys Leu Gly Arg Arg Asp Gly Met Val Ser Arg Ala Ala Arg Ala Glu 
145                 150                 155                 160 


Thr Ile Leu Pro Lys Pro Thr Met Ser Met Asn Gln Ile Ile Lys Ile 
                165                 170                 175     


Phe Ser Asn Ile Gly Leu Ser Val Gln Glu Met Val Ala Leu Thr Gly 
            180                 185                 190         


Ala His Thr Ile Gly Phe Ser His Cys Ser Glu Ile Ser His Asp Ile 
        195                 200                 205             


Tyr Asn Tyr Ser Arg Thr Gln Met Ser Asp Pro Ser Tyr Asn Thr Arg 
    210                 215                 220                 


Tyr Ala Asp Gly Leu Arg Asn Ala Cys Lys Asp Phe Lys Lys Asn Pro 
225                 230                 235                 240 


Ser Leu Ser Val Phe Asn Asp Ile Met Thr Pro His Asp Phe Asp Asn 
                245                 250                 255     


Asn Tyr Tyr Lys Asn Leu Pro Lys Gly Leu Gly Val Leu Arg Ser Asp 
            260                 265                 270         


Arg Ala Met Met Met Asp Val Arg Thr Arg Lys Tyr Val Glu Leu Tyr 
        275                 280                 285             


Ala Arg Asp Gln Lys Ala Phe Phe Asp Ala Phe Gly Arg Ala Ile Glu 
    290                 295                 300                 


Lys Leu Ser Leu Val Gly Val Lys Ser Gly Arg Asn Gly Gln Ile Arg 
305                 310                 315                 320 


Arg Arg Cys Asp Ser Phe Asn 
                325         


<210>  21
<211>  351
<212>  PRT
<213>  Artemisia annua

<400>  21

Met Ser Tyr Ile Tyr Ala Ile Phe Ile Leu Val Thr Leu Arg Cys Val 
1               5                   10                  15      


Val His Ser Glu Ala Gln Leu Gln Val Gly Phe Tyr Ser His Ser Cys 
            20                  25                  30          


Pro Ala Ala Glu Phe Ile Val Lys Asp Glu Val Ser Lys Ala Phe Ser 
        35                  40                  45              


Gln Asn Asn Gly Leu Ala Ala Gly Leu Val Arg Leu His Phe His Asp 
    50                  55                  60                  


Cys Phe Val Arg Gly Cys Asp Gly Ser Val Leu Ile Asp Ser Thr Pro 
65                  70                  75                  80  


Ser Asn Thr Ala Glu Lys Asp Ser Pro Ala Asn Asn Pro Ser Leu Arg 
                85                  90                  95      


Gly Phe Asn Val Ile Asp Asn Ala Lys Ser Arg Leu Glu Lys Ala Cys 
            100                 105                 110         


Pro Gly Val Val Ser Cys Ala Asp Ile Val Ala Phe Ala Ala Arg Asp 
        115                 120                 125             


Gly Phe Gln Ile Thr Gly Gly Leu Gly Tyr Asp Val Pro Ala Gly Arg 
    130                 135                 140                 


Arg Asp Gly Arg Val Ser Arg Ile Ala Asp Thr Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Pro Thr Ser Asn Leu Asn Gln Leu Thr Gln Leu Phe Ala Ser Asn Gly 
                165                 170                 175     


Leu Thr Gln Glu Glu Met Val Thr Leu Ser Gly Ala His Thr Ile Gly 
            180                 185                 190         


Arg Ser His Cys Thr Ser Phe Val Asn Arg Leu Tyr Asn Phe Ser Pro 
        195                 200                 205             


Ser Ala Lys Gln Asp Pro Thr Leu Asp Lys Leu Tyr Ala Ser Lys Leu 
    210                 215                 220                 


Lys Gln Gln Cys Pro Lys Gly Ser Asn Asn Val Asn Leu Val Val Pro 
225                 230                 235                 240 


Met Asn Pro Ser Ser Pro Thr Val Ser Asp Thr Glu Tyr Tyr Val Asp 
                245                 250                 255     


Val Leu Asn Asn Arg Gly Leu Phe Thr Ser Asp Gln Ser Leu Leu Thr 
            260                 265                 270         


Ser Lys Ser Thr Ala Asn Gln Val His Gln Asn Ala Met Asp Pro Leu 
        275                 280                 285             


Leu Trp Lys Ser Lys Phe Ala Lys Ala Met Val Gln Met Gly Lys Asn 
    290                 295                 300                 


Gly Val Leu Thr Gly Arg Gln Gly Glu Ile Arg Lys Asn Cys Arg Val 
305                 310                 315                 320 


Ile Asn Lys Cys Asn Leu Lys Asn Lys Gln Glu Asn Leu Glu Leu Cys 
                325                 330                 335     


Ser Glu Glu Leu Lys Gln Glu Gly Thr Ala Trp Gln Ala Glu Ser 
            340                 345                 350     


<210>  22
<211>  316
<212>  PRT
<213>  Artemisia annua

<400>  22

Met Ala Ile Met Ser Ala Leu Leu Ile Ser Leu Leu Ile Leu Ser Asn 
1               5                   10                  15      


Phe Ser Leu Gly Thr Ser Leu Ser Ser Asn Tyr Tyr Thr Lys Thr Cys 
            20                  25                  30          


Pro Asn Val Glu Ser Leu Ile Arg Lys Ala Val Arg Asp Ala Ala Thr 
        35                  40                  45              


Ser Asp Lys Lys Val Pro Ala Ala Leu Leu Arg Met His Phe His Asp 
    50                  55                  60                  


Cys Phe Ile Arg Gly Cys Asp Ala Ser Val Leu Leu Asp Ser Lys Gly 
65                  70                  75                  80  


Lys Asn Thr Ala Glu Lys Asp Gly Pro Pro Asn Val Ser Leu His Ala 
                85                  90                  95      


Phe Tyr Val Ile Asp Asn Ala Lys Lys Ala Val Glu Ser Ala Cys Pro 
            100                 105                 110         


Gly Ile Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ala 
        115                 120                 125             


Val Val Leu Ser Gly Gly Pro Ser Trp Asp Val Pro Lys Gly Arg Lys 
    130                 135                 140                 


Asp Gly Arg Thr Ser Lys Ala Ser Glu Thr Ile Gln Leu Pro Ala Pro 
145                 150                 155                 160 


Thr Phe Asn Ile Ser Gln Leu Gln Gln Asn Phe Ser Gln Arg Gly Leu 
                165                 170                 175     


Ser Leu Glu Asp Leu Val Ala Leu Ser Gly Gly His Thr Leu Gly Phe 
            180                 185                 190         


Ser His Cys Ser Ser Phe Asn Asn Arg Ile His Asn Phe Asn Ser Thr 
        195                 200                 205             


Thr Asp Val Asp Pro Ser Ile His Pro Ser Phe Ala Ala Ser Leu Arg 
    210                 215                 220                 


Ser Ile Cys Pro Ala Lys Asn Asn Ala Lys Asn Ala Gly Val Pro Met 
225                 230                 235                 240 


Asp Pro Ser Ser Thr Ser Phe Asp Asn Thr Tyr Tyr Lys Leu Ile Phe 
                245                 250                 255     


Gln Gln Lys Ala Leu Phe Ser Ser Asp Lys Ala Leu Leu Asp Ser Pro 
            260                 265                 270         


Lys Thr Lys Asn Leu Ala Met Lys Phe Ala Ser Ser Lys Asp Ala Phe 
        275                 280                 285             


Thr Lys Ala Phe Ile Lys Ser Met Ile Lys Met Ser Ser Ile Thr Gly 
    290                 295                 300                 


Gly Gln Glu Ile Arg Lys Asp Cys Lys Met Val Asn 
305                 310                 315     


<210>  23
<211>  329
<212>  PRT
<213>  Artemisia annua

<400>  23

Met Ala Ala Met Ser Ala Leu Leu Thr Ser Leu Leu Ile Leu Ser Asn 
1               5                   10                  15      


Phe Ser Leu Gly Thr Ser Leu Ser Ser Asn Tyr Tyr Ala Lys Thr Cys 
            20                  25                  30          


Pro Asn Val Glu Ser Val Ile Arg Lys Ala Val Arg Asp Ala Ala Thr 
        35                  40                  45              


Arg Asp Lys Lys Val Pro Ala Ala Leu Leu Arg Met His Phe His Asp 
    50                  55                  60                  


Cys Phe Ile Arg Gly Cys Asp Ala Ser Val Leu Leu Asp Ser Lys Gly 
65                  70                  75                  80  


Lys Asn Thr Ala Glu Lys Asp Gly Pro Pro Asn Val Ser Leu His Ala 
                85                  90                  95      


Phe Tyr Val Ile Asp Asn Ala Lys Lys Ala Val Glu Ala Ala Cys Pro 
            100                 105                 110         


Gly Ile Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ala 
        115                 120                 125             


Val Val Leu Gly Ser Lys Arg Ser Met Phe Leu Met Phe Leu Val Gln 
    130                 135                 140                 


Ser Gly Gly Pro Ser Trp Asp Val Pro Lys Gly Arg Lys Asp Gly Arg 
145                 150                 155                 160 


Thr Ser Lys Ala Ser Glu Thr Ile Gln Leu Pro Ala Pro Thr Phe Asn 
                165                 170                 175     


Ile Ser Gln Leu Gln Gln Ser Phe Ala His Arg Gly Leu Ser Leu Glu 
            180                 185                 190         


Asp Leu Val Ala Leu Ser Gly Gly His Thr Leu Gly Phe Ser His Cys 
        195                 200                 205             


Ser Ser Phe Lys Asn Arg Ile His Asn Phe Asn Ser Thr Thr Asp Val 
    210                 215                 220                 


Asp Pro Ser Ile His Pro Ser Phe Ala Ala Ser Leu Arg Ser Thr Cys 
225                 230                 235                 240 


Leu Ala Lys Asn Asn Ala Lys Asn Ala Gly Val Pro Met Asp Pro Ser 
                245                 250                 255     


Ser Thr Ser Phe Asp Asn Thr Tyr Tyr Lys Leu Ile Phe Gln Gln Lys 
            260                 265                 270         


Ala Leu Phe Ser Ser Asp Lys Ala Leu Leu Asp Phe Pro Lys Ser Lys 
        275                 280                 285             


Asn Leu Ala Met Lys Phe Ala Ser Ser Lys Asp Ala Phe Thr Lys Ala 
    290                 295                 300                 


Phe Ile Lys Ser Met Ile Lys Met Ser Ser Ile Thr Gly Gly Gln Glu 
305                 310                 315                 320 


Val Arg Lys Asp Cys Lys Val Val Asn 
                325                 


<210>  24
<211>  328
<212>  PRT
<213>  Artemisia annua

<400>  24

Met Met Ser Thr Thr Ser Leu Asn Ala Thr Phe Phe Val Lys Leu Met 
1               5                   10                  15      


Leu Val Leu Met Leu Met Ser Pro Leu Gln Ala Gln Gln Leu Gln Val 
            20                  25                  30          


Gly Phe Tyr Ser Gly Ser Cys Phe Met Ala Glu Phe Ile Val Lys Asp 
        35                  40                  45              


Glu Val Thr Lys Ala Phe Phe Arg Asp Arg Gly Leu Ala Ala Gly Leu 
    50                  55                  60                  


Val Arg Leu His Phe His Asp Cys Phe Val Arg Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Val Val Leu Asp Ser Thr Pro Ser Asn Thr Ala Glu Lys Asp Ser Pro 
                85                  90                  95      


Ala Asn Asn Pro Ser Leu Arg Gly Phe Asp Val Ile Asp Asn Ala Lys 
            100                 105                 110         


Ala Arg Ile Glu Ser Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile 
        115                 120                 125             


Ile Ala Phe Ala Ala Arg Asp Ser Ile Ile Leu Thr Gly Gly Leu Gly 
    130                 135                 140                 


Tyr Asp Val Pro Ala Gly Arg Arg Asp Gly Arg Val Ser Leu Ile Ala 
145                 150                 155                 160 


Glu Thr Arg Ala Leu Pro Pro Ser Thr Ala Asn Leu Asn Gln Leu Thr 
                165                 170                 175     


Gln Met Phe Ser Thr His Gly Leu Thr Gln Glu Asp Met Val Thr Leu 
            180                 185                 190         


Ser Gly Ala His Thr Ile Gly Arg Ser His Cys Thr Ser Phe Ser Ser 
        195                 200                 205             


Arg Leu Tyr Ser Tyr Asn Thr Thr Val Asn Gln Asp Pro Thr Leu Asn 
    210                 215                 220                 


Ala Phe Tyr Ala Ser Gln Leu Met Gln Gln Cys Pro Lys Gly Gly Pro 
225                 230                 235                 240 


Asp Ser Val Val Pro Ile Asn Pro Ala Ser Pro Thr Ile Thr Asp Val 
                245                 250                 255     


Gly Tyr Tyr Val Asp Ile Leu Asn Asn Arg Gly Leu Phe Thr Ser Asp 
            260                 265                 270         


Gln Thr Leu Leu Ser Thr Thr Ser Thr Ala Asn Gln Val Thr Arg Tyr 
        275                 280                 285             


Ala Ile Asn Pro Leu Leu Trp Lys Thr Lys Phe Ala Ala Ala Met Val 
    290                 295                 300                 


Lys Met Gly Lys Ile Gly Val Leu Thr Gly Ala Gln Gly Glu Ile Arg 
305                 310                 315                 320 


Ser Asn Cys Ser Val Ile Asn Asn 
                325             


<210>  25
<211>  313
<212>  PRT
<213>  Artemisia annua

<400>  25

Met Ala Ala Leu Leu Ser Ser Leu Leu Ile Leu Ser Phe Phe Ser Leu 
1               5                   10                  15      


Gly Thr Ser Leu Ser Ser Asn Tyr Tyr Gln Lys Thr Cys Pro Asn Ala 
            20                  25                  30          


Glu Ser Ile Ile Lys Lys Ala Val Ile Asp Ala Thr Lys Asn Asp Lys 
        35                  40                  45              


Thr Ala Pro Ala Ala Leu Val Arg Met His Phe His Asp Cys Phe Ile 
    50                  55                  60                  


Arg Gly Cys Asp Gly Ser Val Leu Ile Asn Ser Lys Gly Lys Asn Thr 
65                  70                  75                  80  


Ala Glu Lys Asp Gly Pro Pro Asn Lys Ser Leu His Ala Phe Tyr Val 
                85                  90                  95      


Ile Asp Asn Ala Lys Lys Ala Leu Glu Ser Ala Cys Pro Gly Val Val 
            100                 105                 110         


Ser Cys Ala Asp Ile Leu Ala Val Ala Ala Arg Asp Ala Thr Val Val 
        115                 120                 125             


Ser Gly Gly Pro Ser Trp Asp Val Pro Lys Gly Arg Lys Asp Gly Arg 
    130                 135                 140                 


Ile Ser Arg Ala Ser Glu Thr Ser Gln Leu Pro Ala Pro Thr Phe Asn 
145                 150                 155                 160 


Ile Ser Gln Leu Gln Gln Ser Trp Ser Gln Arg Gly Leu Ser Met Glu 
                165                 170                 175     


Asp Leu Val Ala Leu Ser Gly Gly His Thr Leu Gly Phe Ser His Cys 
            180                 185                 190         


Ser Ser Phe Asn Asn Arg Ile His Asn Phe Asn Ser Thr Phe Asp Ile 
        195                 200                 205             


Asp Pro Ser Leu Gln Pro Ser Phe Ala Ala Thr Leu Arg Arg Val Cys 
    210                 215                 220                 


Pro Ala Arg Asn Asn Ala Lys Lys Ala Gly Val Thr Met Asp Pro Ser 
225                 230                 235                 240 


Ser Thr Thr Phe Asp Asn Thr Tyr Tyr Lys Leu Ile Leu Gln Asn Lys 
                245                 250                 255     


Val Val Phe Ser Ser Asp Asn Ala Leu Leu Asn Ser Pro Lys Thr Lys 
            260                 265                 270         


Ser Leu Val Ser Lys Phe Ala Ser Ser Ser Asp Ala Phe Phe Lys Ala 
        275                 280                 285             


Phe Ala Lys Ser Met Ile Lys Met Ser Ser Ile Thr Gly Gly Gln Glu 
    290                 295                 300                 


Ile Arg Lys Asp Cys Arg Val Val Asn 
305                 310             


<210>  26
<211>  323
<212>  PRT
<213>  Artemisia annua

<400>  26

Met Ala Val Lys Asn Thr Thr Ile Phe Ser Leu Leu Phe Ser Leu Ala 
1               5                   10                  15      


Phe Leu Gly Leu Thr Cys Val His Leu Thr Asn Ala Leu Ser Ser Asn 
            20                  25                  30          


Tyr Tyr Asp Lys Thr Cys Pro Asn Val Glu Ala Thr Ile Thr Ser Val 
        35                  40                  45              


Val Lys Lys Ala Met Leu Asn Asp Arg Thr Val Pro Ala Ala Leu Leu 
    50                  55                  60                  


Arg Met His Phe His Asp Cys Phe Ile Arg Gly Cys Asp Gly Ser Val 
65                  70                  75                  80  


Leu Leu Asn Ser Thr Lys Lys Asn Gln Ala Glu Lys Asp Gly Pro Pro 
                85                  90                  95      


Asn Ile Ser Leu His Ala Phe Tyr Val Ile Asp Asn Ala Lys Lys Ala 
            100                 105                 110         


Leu Glu Ala Leu Cys Pro Lys Thr Val Ser Cys Ala Asp Ile Leu Ala 
        115                 120                 125             


Leu Ala Ala Arg Asp Ala Val Thr Leu Ser Gly Gly Pro Asn Trp Asn 
    130                 135                 140                 


Val Pro Lys Gly Arg Lys Asp Gly Arg Val Ser Lys Ala Thr Asp Thr 
145                 150                 155                 160 


Arg Gln Leu Pro Gly Pro Thr Phe Asn Ile Ser Gln Leu Gln Gln Ser 
                165                 170                 175     


Phe Ala Gln Arg Gly Leu Gly Thr Glu Asp Leu Val Ala Leu Ser Gly 
            180                 185                 190         


Gly His Thr Leu Gly Phe Ala His Cys Ser Ser Phe Gln Asn Arg Ile 
        195                 200                 205             


His Asn Phe Ser Pro Lys Lys Ser Val Asp Pro Thr Leu Gln Ser Ser 
    210                 215                 220                 


Phe Ala Ala Ser Leu Lys Asn Val Cys Pro Ala Lys Asn Thr Pro Lys 
225                 230                 235                 240 


Asn Ala Gly Ala Asn Leu Asp Ser Thr Pro Thr Thr Phe Asp Asn Arg 
                245                 250                 255     


Tyr Tyr Lys Leu Leu Leu Gln Gly Lys Ser Ile Phe Ser Ser Asp Gln 
            260                 265                 270         


Ala Leu Ala Thr Met Ala Asn Thr Lys Ala Leu Val Thr Lys Tyr Ala 
        275                 280                 285             


Ser Ser Lys Lys Glu Phe Glu Lys Ala Phe Val Lys Ser Met Ile Lys 
    290                 295                 300                 


Met Ser Ser Ile Asn Gly Gly Gly Gln Glu Val Arg His Asp Cys Arg 
305                 310                 315                 320 


Val Val Asn 
            


<210>  27
<211>  1036
<212>  PRT
<213>  Artemisia annua

<400>  27

Met Ser Tyr Ile Tyr Ala Ile Phe Ile Leu Val Thr Leu Arg Cys Val 
1               5                   10                  15      


Val His Ser Glu Ala Gln Leu Gln Val Gly Phe Tyr Ser His Ser Cys 
            20                  25                  30          


Pro Ala Ala Glu Phe Ile Val Lys Asp Glu Val Ser Lys Ala Phe Ser 
        35                  40                  45              


Gln Asn Lys Gly Leu Ala Ala Gly Leu Val Arg Leu His Phe His Asp 
    50                  55                  60                  


Cys Phe Val Arg Gly Cys Asp Gly Ser Val Leu Ile Asp Ser Thr Pro 
65                  70                  75                  80  


Ser Asn Thr Ala Glu Lys Asp Ser Pro Ala Asn Asn Pro Ser Leu Arg 
                85                  90                  95      


Gly Phe Asn Val Ile Asp Asn Ala Lys Ser Arg Leu Glu Lys Ala Cys 
            100                 105                 110         


Pro Gly Val Val Ser Cys Ala Asp Ile Val Ala Phe Ala Ala Arg Asp 
        115                 120                 125             


Gly Phe Gln Ile Thr Gly Gly Leu Gly Tyr Asp Val Pro Ala Gly Arg 
    130                 135                 140                 


Arg Asp Gly Arg Val Ser Arg Ile Ala Asp Thr Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Pro Thr Ser Asn Leu Asn Gln Leu Thr Gln Leu Phe Ala Ser Asn Gly 
                165                 170                 175     


Leu Thr Gln Glu Glu Met Val Thr Leu Ser Gly Ala His Thr Ile Gly 
            180                 185                 190         


Arg Ser His Cys Thr Ser Phe Val Asn Arg Leu Tyr Asn Phe Ser Pro 
        195                 200                 205             


Ser Ala Lys Gln Asp Pro Thr Leu Asp Lys Leu Tyr Ala Ser Lys Leu 
    210                 215                 220                 


Lys Gln Gln Cys Pro Lys Gly Ser Asn Asn Ala Asn Leu Val Val Pro 
225                 230                 235                 240 


Met Asn Pro Ser Ser Pro Thr Val Ser Asp Thr Glu Tyr Tyr Val Asp 
                245                 250                 255     


Val Leu Asn Asn Arg Gly Leu Phe Thr Ser Asp Gln Ser Leu Leu Thr 
            260                 265                 270         


Ser Lys Ser Thr Ala Asn Gln Val His Gln Asn Ala Met Asp Pro Leu 
        275                 280                 285             


Leu Trp Lys Ser Lys Phe Ala Lys Ala Met Val Gln Met Gly Lys Asn 
    290                 295                 300                 


Gly Val Leu Thr Gly Arg Gln Gly Glu Ile Arg Lys Asn Cys Arg Val 
305                 310                 315                 320 


Ile Asn Lys Cys Leu Asp Val Val Cys Lys Gln Leu Ser Asp Phe Glu 
                325                 330                 335     


Cys Ser Phe Pro Val Glu Val Ala Cys Asp Ile Leu Arg Leu Asp Lys 
            340                 345                 350         


Trp Asp Gly Asp Glu Arg Ser Glu Phe Val Pro Ser Asn Ile Thr Thr 
        355                 360                 365             


Ile Ser Phe Ser Ser Thr Pro Leu Phe Leu Asp Thr Ser Val Pro Gln 
    370                 375                 380                 


Ile Pro Tyr Ser Thr Ala Arg Val Phe Asn Thr Ser Ser Phe Thr Tyr 
385                 390                 395                 400 


Thr Phe Pro Val Ser Glu Gly Pro Lys Phe Val Arg Leu Tyr Phe Tyr 
                405                 410                 415     


Pro Ala Thr Tyr Ser Gly Leu Asn Ala Asn Leu Ser Ser Phe Ser Val 
            420                 425                 430         


Ser Ser Asn Gly Tyr Ser Leu Leu Thr Asn Phe Ser Ala Phe Leu Thr 
        435                 440                 445             


Ala Leu Phe Leu Ala Lys Thr Cys Asp Gly Pro Pro Val Pro His Phe 
    450                 455                 460                 


Val Lys Glu Phe Leu Ile Tyr Val Gln Asp Thr Gln Phe Leu Ser Val 
465                 470                 475                 480 


Val Phe Thr Pro Ala Pro Asn Ser Tyr Ala Phe Ile Asn Gly Ile Glu 
                485                 490                 495     


Ile Val Ser Met Pro Asp Asn Leu Tyr Phe Asn Ala Lys Asn Pro Lys 
            500                 505                 510         


Pro Val Gly Met Ser Thr Gly His Val Ile Asn Ser Asp Thr Ala Leu 
        515                 520                 525             


Glu Thr Val Tyr Arg Leu Asn Val Gly Gly Ala Gln Ile Ser Gly Ile 
    530                 535                 540                 


Asn Asp Thr Gly Ile Tyr Arg Ser Trp Asp Gln Asp Ile Asn Tyr Ile 
545                 550                 555                 560 


Tyr Gly Pro Ile Gly Val Thr Pro Leu Asn Glu Asn Pro Ile Ala Tyr 
                565                 570                 575     


Thr Glu Thr Thr Pro Asn Tyr Thr Ala Pro Glu Ala Ile Tyr Gln Thr 
            580                 585                 590         


Gln Arg Ser Met Gly Ile Gln Ser Glu Leu Tyr Asn Leu Thr Trp Ile 
        595                 600                 605             


Leu Pro Val Asp Ser Gly Phe Tyr Tyr Met Leu Arg Phe His Phe Ser 
    610                 615                 620                 


Ser Ile Ile Pro Gln Tyr Thr Lys Asp Leu Gln Met Ile Phe Arg Ile 
625                 630                 635                 640 


Phe Ile Asn Asn Gln Thr Ala Glu Asp Asp Ala Asp Ile Ile Tyr Trp 
                645                 650                 655     


Ala Gln Gly Ser Arg Ile Pro Val Tyr Arg Asp Tyr Val Val Leu Val 
            660                 665                 670         


Asn Asn Pro Ser Gly His Arg Ser Lys Gln Asp Leu Trp Leu Gln Met 
        675                 680                 685             


His Pro Asn Leu Glu Val Ser Lys Glu Tyr Leu Asp Ala Tyr Leu Asn 
    690                 695                 700                 


Gly Leu Glu Ala Phe Lys Leu Ser Met Asn His Asp Leu Ser Ser Pro 
705                 710                 715                 720 


Met Leu Ser Glu Lys Asn Leu Ser Ser Pro Thr Pro Asn Leu Val Ser 
                725                 730                 735     


Ser Arg Lys Glu Asn Asn Asn Lys Thr Pro Pro Ser Ala Leu Ile Ile 
            740                 745                 750         


Gly Gly Ala Gly Gly Gly Leu Val Leu Leu Ser Val Leu Leu Leu Leu 
        755                 760                 765             


Val Leu Tyr Gln Arg Arg Arg Thr Lys His His Thr Thr Thr Asn Asn 
    770                 775                 780                 


Lys Pro Ser Leu Leu Ser Asp Cys Cys Arg Arg Phe Ser Leu Lys Gln 
785                 790                 795                 800 


Val Lys Val Ala Thr Asn Lys Phe Asn Glu Asn Asn Val Ile Gly Asn 
                805                 810                 815     


Gly Gly Phe Gly Lys Val Tyr Lys Gly Tyr Met Gly Asn Ala Lys Thr 
            820                 825                 830         


Thr Val Ala Ile Lys Arg Leu Asn Pro Ser Ser Ser Gln Gly Phe His 
        835                 840                 845             


Glu Phe Gln Thr Glu Ile Gln Met Leu Ser Arg Leu Arg His Glu His 
    850                 855                 860                 


Leu Val Ser Leu Ile Gly Tyr Cys Asp Asp Asn Gly Glu Met Ile Leu 
865                 870                 875                 880 


Val Tyr Asp Tyr Met Ser Arg Gly Asn Leu Arg Glu His Leu Tyr Lys 
                885                 890                 895     


Thr Asn Asn Pro Pro Leu Ser Trp Lys Thr Arg Leu Asn Ile Cys Ile 
            900                 905                 910         


Gly Ala Ala Lys Gly Glu Gln Val Thr Leu Ala Glu Trp Gly Lys Thr 
        915                 920                 925             


Cys Tyr Gln Arg Gly Thr Leu Val Glu Ile Ile Asp Gln Asn Leu Ser 
    930                 935                 940                 


Asp Gln Ile Ala Pro Gly Ser Leu Arg Lys Phe Gly Glu Val Ala Asn 
945                 950                 955                 960 


Ser Cys Leu His Glu Glu Val Ser Glu Arg Pro Thr Met Asp Ala Val 
                965                 970                 975     


Val Gln Gly Leu Glu Val Ala Leu Gln Leu Gln Glu Asp Cys Glu Glu 
            980                 985                 990         


Met Gly Gly Ile Val Gly Glu Glu  Met Leu Glu Ser Gln  Asp Leu His 
        995                 1000                 1005             


Phe His  Met Gln Val Glu Leu  Thr Lys Thr Asp Asp  Asp Gly Ile 
    1010                 1015                 1020             


Glu Asp  Gly Glu Val Val Ala  His Gln Gly Ala His  Ser 
    1025                 1030                 1035     


<210>  28
<211>  372
<212>  PRT
<213>  Artemisia annua

<400>  28

Met Ala Ile Asn Thr Ser His Glu Pro Gln Ala Pro Thr His Lys Leu 
1               5                   10                  15      


Ile Phe Met Ala Met Ala Phe Ser Lys Ala Ser Cys Gln Ser Thr Leu 
            20                  25                  30          


Ile Phe Ala Leu Phe Leu Leu Cys Asn Leu Arg Ala Leu Glu Ala Gln 
        35                  40                  45              


Thr Pro Ala Pro Ala Pro Gly Leu Ser Tyr Thr Phe Tyr Arg Thr Thr 
    50                  55                  60                  


Cys Pro Asn Leu Glu Thr Ile Ile Arg Gln Gln Leu Gln Thr Val Phe 
65                  70                  75                  80  


Ala Ser Asp Ile Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His 
                85                  90                  95      


Asp Cys Phe Val Gln Gly Cys Asp Ala Ser Val Leu Leu Asp Gly Ser 
            100                 105                 110         


Ala Ser Gly Pro Ser Glu Lys Asp Ala Pro Pro Asn Leu Thr Leu Arg 
        115                 120                 125             


Ala Gln Ala Phe Val Ile Ile Glu Asn Leu Arg Arg Leu Val His Asn 
    130                 135                 140                 


Ala Cys Asn Arg Thr Val Ser Cys Ala Asp Ile Thr Ala Leu Ala Ala 
145                 150                 155                 160 


Arg Asp Ala Val Phe Leu Ser Gly Gly Pro Asn Tyr Ser Ile Pro Leu 
                165                 170                 175     


Gly Arg Arg Asp Gly Leu Thr Phe Ala Thr Val Asn Val Thr Leu Ala 
            180                 185                 190         


Asn Leu Pro Pro Pro Thr Ala Asn Ala Ser Thr Ile Leu Ser Ser Leu 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Pro Thr Asp Val Val Ser Leu Ser Gly Gly 
    210                 215                 220                 


His Thr Ile Gly Ile Gly His Cys Gly Ser Phe Asn Asn Arg Ile Tyr 
225                 230                 235                 240 


Pro Ser Arg Asp Pro Ser Met Asp Gln Thr Phe Phe Asn Asn Leu Arg 
                245                 250                 255     


Leu Thr Cys Pro Thr Asn Thr Ser Asn Asn Thr Thr Val Leu Asp Ile 
            260                 265                 270         


Arg Ser Pro Asn Val Phe Asp Asn Lys Tyr Tyr Val Asp Leu Met Asn 
        275                 280                 285             


Arg Gln Gly Leu Phe Thr Ser Asp Gln Asp Leu Tyr Thr Asp Ser Arg 
    290                 295                 300                 


Thr Arg Thr Ile Val Thr Asn Phe Ala Val Asn Gln Thr Leu Phe Tyr 
305                 310                 315                 320 


Gln Asn Phe Ile Asn Ala Met Ile Lys Met Gly Gln Leu Asn Val Leu 
                325                 330                 335     


Thr Gly Thr Gln Gly Glu Ile Arg Ala Asn Cys Ser Arg Arg Asn Ser 
            340                 345                 350         


Asn Asp Leu Phe Ile Leu Pro Thr Met Glu Asn Asp Gln Asp Glu Lys 
        355                 360                 365             


Val Ala Ser Tyr 
    370         


<210>  29
<211>  352
<212>  PRT
<213>  Artemisia annua

<400>  29

Met Ala Phe Ser Lys Ala Ser Cys Gln Ser Thr Leu Ile Phe Ala Leu 
1               5                   10                  15      


Leu Leu Leu Cys Asn Leu Arg Ala Leu Glu Ala Gln Thr Pro Ala Pro 
            20                  25                  30          


Ala Pro Gly Leu Ser Tyr Thr Phe Tyr Arg Thr Thr Cys Pro Asn Leu 
        35                  40                  45              


Glu Thr Ile Ile Arg Gln Gln Leu Gln Thr Val Phe Ala Ser Asp Ile 
    50                  55                  60                  


Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His Asp Cys Phe Val 
65                  70                  75                  80  


Gln Gly Cys Asp Ala Ser Val Leu Leu Asp Gly Ser Ala Ser Gly Pro 
                85                  90                  95      


Ser Glu Lys Asp Ala Pro Pro Asn Leu Thr Leu Arg Ala Gln Ala Phe 
            100                 105                 110         


Val Ile Ile Glu Asn Leu Arg Arg Leu Val His Asn Ala Cys Asn Arg 
        115                 120                 125             


Thr Val Ser Cys Ala Asp Ile Thr Ala Leu Ala Ala Arg Asp Ala Val 
    130                 135                 140                 


Phe Leu Ser Gly Gly Pro Asn Tyr Ser Ile Pro Leu Gly Arg Arg Asp 
145                 150                 155                 160 


Gly Leu Thr Phe Ala Thr Val Asn Val Thr Leu Ala Asn Leu Pro Pro 
                165                 170                 175     


Pro Thr Ala Asn Ala Ser Thr Ile Leu Ser Ser Leu Ala Leu Lys Gly 
            180                 185                 190         


Phe Thr Pro Thr Asp Val Val Ser Leu Ser Gly Gly His Thr Ile Gly 
        195                 200                 205             


Ile Gly His Cys Gly Ser Phe Asn Asn Arg Ile Tyr Pro Ser Arg Asp 
    210                 215                 220                 


Pro Ser Met Asp Gln Thr Phe Phe Asn Asn Leu Arg Leu Thr Cys Pro 
225                 230                 235                 240 


Thr Asn Thr Ser Asn Asn Thr Thr Val Leu Asp Ile Arg Ser Pro Asn 
                245                 250                 255     


Val Phe Asp Asn Lys Tyr Tyr Val Asp Leu Met Asn Arg Gln Gly Leu 
            260                 265                 270         


Phe Thr Ser Asp Gln Asp Leu Tyr Thr Asp Ser Arg Thr Arg Thr Ile 
        275                 280                 285             


Val Thr Asn Phe Ala Val Asn Gln Thr Leu Phe Tyr Gln Asn Phe Ile 
    290                 295                 300                 


Asn Ala Met Ile Lys Met Gly Gln Leu Asn Val Leu Thr Gly Thr Gln 
305                 310                 315                 320 


Gly Glu Ile Arg Ala Asn Cys Ser Arg Arg Asn Ser Asn Asp Leu Phe 
                325                 330                 335     


Ile Leu Pro Thr Met Glu Asn Asp Gln Asp Glu Lys Val Ala Ser Tyr 
            340                 345                 350         


<210>  30
<211>  694
<212>  PRT
<213>  Artemisia annua

<400>  30

Met Thr Asn Lys Ile Gln Pro Gln Gln Phe Pro Thr Ile Thr Glu Asn 
1               5                   10                  15      


Leu Leu Ser Phe Asp Ser Met Phe His Gln Leu His Thr Leu Leu Ile 
            20                  25                  30          


Leu Leu Ala Thr Met Gly Asn Ser Arg Leu Phe Gln Leu Ile Phe Leu 
        35                  40                  45              


Ile Ile Thr Ser Ile Leu Thr Ser Ile Asp Ala Ser Ala Lys Tyr Leu 
    50                  55                  60                  


His Arg Asn Asn His Lys Asn Pro Pro Pro Pro Pro Leu Thr Leu Asp 
65                  70                  75                  80  


Tyr Tyr Ala Lys Thr Cys Pro Arg Phe His Glu Ile Val Arg Thr Thr 
                85                  90                  95      


Val Val Pro Lys Gln Leu Ser His Pro Thr Thr Ala Ala Ala Thr Leu 
            100                 105                 110         


Arg Leu Phe Phe His Asp Cys Met Val Gly Gly Cys Asp Ala Ser Val 
        115                 120                 125             


Leu Ile Ala Ser Asn Ala Tyr Asn Lys Ala Glu Arg Asp Tyr Asp Ile 
    130                 135                 140                 


Asn Glu Ser Leu Ala Gly Asp Gly Phe Asp Val Val Thr Arg Val Lys 
145                 150                 155                 160 


Met Ala Leu Glu Val Glu Cys Pro Gly Val Val Ser Cys Ser Asp Val 
                165                 170                 175     


Leu Ala Ile Thr Thr Arg Asp Leu Leu Ile Gln Val Gly Gly Pro His 
            180                 185                 190         


Tyr Glu Val Lys Leu Gly Arg Lys Asp Gly Leu Glu Ser Lys Ala Ser 
        195                 200                 205             


Asn Val Glu Gly Lys Leu Gly Arg Ala Asn Met Thr Leu Asn Glu Val 
    210                 215                 220                 


Ile Arg Val Phe Glu Ser His Lys Tyr Thr His Arg Glu Met Val Ala 
225                 230                 235                 240 


Leu Met Gly Gly Gly His Thr Ile Gly Phe Ala His Cys Lys Glu Phe 
                245                 250                 255     


Glu Ser Arg Leu Phe Gly Pro Lys Pro Asp Pro Ser Val His Pro Lys 
            260                 265                 270         


Leu Ala Glu Arg Leu Lys Ala Met Cys Val Asn Arg Ser Lys Asp Pro 
        275                 280                 285             


Ser Val Ser Ala Phe Leu Asp Pro Ile Ser Ala Gly Asn Phe Asp Asn 
    290                 295                 300                 


Met Ile Phe Lys Asn Ile Leu Asn Gly Leu Gly Val Leu Gly Thr Asp 
305                 310                 315                 320 


Gln Ala Met Ala Ser Asp Pro Arg Thr Arg Pro Leu Val Glu Glu Tyr 
                325                 330                 335     


Ala Arg Asp Ser Ala Lys Phe Phe Asn Asp Phe Ala Arg Ala Met Glu 
            340                 345                 350         


Lys Thr Ser Val Tyr Gln Val Lys Thr Gly Asn Gln Gly Glu Val Arg 
        355                 360                 365             


His Ala Ser Ala Lys Tyr Leu His Arg Asn Asn His Lys Asn Pro Pro 
    370                 375                 380                 


Pro Pro Pro Leu Thr Leu Asp Tyr Tyr Ala Lys Thr Cys Pro Arg Phe 
385                 390                 395                 400 


His Glu Ile Val Arg Thr Thr Val Val Pro Lys Gln Leu Ser His Pro 
                405                 410                 415     


Thr Thr Ala Ala Ala Thr Leu Arg Leu Phe Phe His Asp Cys Met Val 
            420                 425                 430         


Gly Gly Cys Asp Ala Ser Val Leu Ile Ala Ser Asn Ala Tyr Asn Lys 
        435                 440                 445             


Ala Glu Arg Asp Tyr Asp Ile Asn Glu Ser Leu Ala Gly Asp Gly Phe 
    450                 455                 460                 


Asp Val Val Thr Arg Val Lys Met Ala Leu Glu Val Glu Cys Pro Gly 
465                 470                 475                 480 


Val Val Ser Cys Ser Asp Val Leu Ala Ile Thr Thr Arg Asp Leu Leu 
                485                 490                 495     


Ile Gln Val Gly Gly Pro His Tyr Glu Val Lys Leu Gly Arg Lys Asp 
            500                 505                 510         


Gly Leu Glu Ser Lys Ala Ser Asn Val Glu Gly Lys Leu Gly Arg Ala 
        515                 520                 525             


Asn Met Thr Leu Asn Glu Val Ile Arg Val Phe Glu Ser His Lys Tyr 
    530                 535                 540                 


Thr His Arg Glu Met Val Ala Leu Met Gly Gly Gly His Thr Ile Gly 
545                 550                 555                 560 


Phe Ala His Cys Lys Glu Phe Glu Ser Arg Leu Phe Gly Pro Lys Pro 
                565                 570                 575     


Asp Pro Ser Val His Pro Lys Leu Ala Glu Arg Leu Lys Ala Met Cys 
            580                 585                 590         


Val Asn Arg Ser Lys Asp Pro Ser Val Ser Ala Phe Leu Asp Pro Ile 
        595                 600                 605             


Ser Ala Gly Asn Phe Asp Asn Met Ile Phe Lys Asn Ile Leu Asn Gly 
    610                 615                 620                 


Leu Gly Val Leu Gly Thr Asp Gln Ala Met Ala Ser Asp Pro Arg Thr 
625                 630                 635                 640 


Arg Pro Leu Val Glu Glu Tyr Ala Arg Asp Ser Ala Lys Phe Phe Asn 
                645                 650                 655     


Asp Phe Ala Arg Ala Met Glu Lys Thr Ser Val Tyr Gln Val Lys Thr 
            660                 665                 670         


Gly Asn Gln Gly Glu Val Arg Arg Arg Cys Asp Ala Phe Asn Asn Leu 
        675                 680                 685             


Pro Asn Gly Arg Lys Thr 
    690                 


<210>  31
<211>  307
<212>  PRT
<213>  Artemisia annua

<400>  31

Met Ile Leu Met Ala Leu Glu Thr Thr Glu Ala Gln Ala Gln Leu Lys 
1               5                   10                  15      


Met Gly Phe Tyr Arg Thr Thr Cys Pro Lys Ala Glu Trp Ile Val Gln 
            20                  25                  30          


Asp Thr Val Asn Lys Ala Val Lys Ala Asn Pro Gly Ile Ala Ala Gly 
        35                  40                  45              


Ile Ile Arg Leu Tyr Phe His Asp Cys Phe Val Arg Gly Cys Asp Ala 
    50                  55                  60                  


Ser Leu Leu Leu Lys Thr Val Gln Gly Ser Glu Asn Glu Ser Glu Gln 
65                  70                  75                  80  


Asp His Pro Ala Asn Ala Gly Thr Leu Arg Gly Leu Glu Ile Phe Asp 
                85                  90                  95      


Gln Ala Lys Ala Arg Leu Glu Ala Ala Cys Pro Asn Thr Val Ser Cys 
            100                 105                 110         


Ala Asp Ile Leu Ala Phe Ala Ala Arg Asp Ser Thr Asn Ala Val Gly 
        115                 120                 125             


Gly Phe Ser Tyr Ala Ile Pro Ser Gly Arg Arg Asp Gly Arg Ile Ser 
    130                 135                 140                 


Asn Ile Gly Asp Val Asp Leu Pro Gly Pro Asp Ser Asp Leu Arg Asn 
145                 150                 155                 160 


Met Arg Ser Lys Phe Met Ala Lys Gly Leu Ser Thr Arg Asp Leu Val 
                165                 170                 175     


Ala Leu Ser Gly Ala His Ser Ile Gly Arg Ser Gly Cys Asn Leu Val 
            180                 185                 190         


Ala Pro Arg Leu Tyr Pro Thr Asp Pro Ser Leu Asp Pro Lys Tyr Ala 
        195                 200                 205             


Ala Phe Leu Lys Thr Lys Cys Pro Lys Asn Arg Leu Ser Gly Thr Thr 
    210                 215                 220                 


Asn Leu Asp Pro Val Ser Ala Asn Arg Leu Asp Asn Gln Tyr Tyr Arg 
225                 230                 235                 240 


Asn Val Lys Gln His Lys Val Leu Phe Ser Ser Asp Glu Ala Leu Leu 
                245                 250                 255     


Asp Ser Ser Glu Thr Ala Arg Ile Val Ala Thr Tyr Thr Asn Asn Thr 
            260                 265                 270         


Asn Ala Trp Arg Met Asp Phe Ala Ala Ala Met Val Arg Met Gly Ser 
        275                 280                 285             


Val Glu Val Leu Thr Gly Thr Lys Gly Glu Ile Arg Lys Lys Cys Ser 
    290                 295                 300                 


Val Ile Asn 
305         


<210>  32
<211>  353
<212>  PRT
<213>  Artemisia annua

<400>  32

Met Thr Met Ala Phe Ser Lys Ala Ser Cys Gln Thr Leu Ile Phe Ala 
1               5                   10                  15      


Leu Leu Leu Leu Cys Asn Leu Arg Ala Leu Glu Ala Gln Thr Pro Ala 
            20                  25                  30          


Pro Ala Pro Gly Leu Ser Tyr Thr Phe Tyr Arg Thr Thr Cys Pro Asn 
        35                  40                  45              


Leu Glu Thr Ile Val Arg Gln Gln Leu Gln Thr Val Phe Ala Ser Asp 
    50                  55                  60                  


Ile Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His Asp Cys Phe 
65                  70                  75                  80  


Val Gln Gly Cys Asp Ala Ser Val Leu Leu Asp Gly Ser Ala Ser Gly 
                85                  90                  95      


Pro Ser Glu Lys Asp Ala Pro Pro Asn Leu Thr Leu Arg Ala Gln Ala 
            100                 105                 110         


Phe Val Ile Ile Glu Asn Leu Arg Arg Leu Val His Asn Ala Cys Asn 
        115                 120                 125             


Arg Thr Val Ser Cys Ala Asp Ile Thr Ala Leu Ala Ala Arg Asp Ala 
    130                 135                 140                 


Val Phe Leu Ser Gly Gly Pro Asn Tyr Ser Ile Pro Leu Gly Arg Arg 
145                 150                 155                 160 


Asp Gly Leu Thr Phe Ala Thr Val Asn Val Thr Leu Ala Asn Leu Pro 
                165                 170                 175     


Pro Pro Thr Ala Asn Ala Ser Phe Ile Leu Glu Ser Leu Ser Thr Lys 
            180                 185                 190         


Gly Phe Thr Pro Thr Asp Val Val Ser Leu Ser Gly Gly His Thr Ile 
        195                 200                 205             


Gly Ile Gly His Cys Gly Ser Phe Ser Asn Arg Ile Phe Pro Ser Arg 
    210                 215                 220                 


Asp Pro Ser Met Asp Gln Thr Phe Phe Asn Asn Leu Arg Leu Thr Cys 
225                 230                 235                 240 


Pro Thr Asn Thr Ser Asn Asn Thr Thr Val Leu Asp Ile Arg Ser Pro 
                245                 250                 255     


Asn Val Phe Asp Asn Lys Tyr Tyr Val Asp Leu Met Asn Arg Gln Gly 
            260                 265                 270         


Leu Phe Thr Ser Asp Gln Asp Leu Tyr Thr Asp Ser Arg Thr Arg Thr 
        275                 280                 285             


Ile Val Thr Asn Phe Ala Val Asn Gln Thr Leu Ser Tyr Gln Asn Phe 
    290                 295                 300                 


Ile Asn Ala Met Ile Lys Met Gly Gln Leu Asn Val Leu Thr Gly Thr 
305                 310                 315                 320 


Gln Gly Glu Ile Arg Ala Asn Cys Ser Arg Arg Asn Ser Asn Asp Leu 
                325                 330                 335     


Phe Ile Leu Pro Asn Met Glu Arg Asp Gln Asp Glu Lys Val Ala Ser 
            340                 345                 350         


Tyr 
    


<210>  33
<211>  402
<212>  PRT
<213>  Artemisia annua

<400>  33

Met Ala Glu Lys Asn Thr Ala Ile Leu Ser Phe Leu Phe Ser Leu Val 
1               5                   10                  15      


Phe Leu Gly Leu Thr Ser Leu Ser Leu Ile Asn Ala Leu Ser Ser Asn 
            20                  25                  30          


Tyr Tyr Asp Gln Thr Cys Pro Lys Ala Glu Ala Glu Ile Thr Ser Ala 
        35                  40                  45              


Val Lys Lys Ala Met Leu Asn Asp Arg Thr Val Pro Ala Ala Leu Leu 
    50                  55                  60                  


Arg Met His Phe His Asp Cys Phe Ile Arg Gly Cys Asp Gly Ser Val 
65                  70                  75                  80  


Leu Leu Asn Ser Thr Ala Asn Asn Gln Ala Glu Lys Asp Gly Pro Pro 
                85                  90                  95      


Asn Ile Ser Leu His Ala Phe Tyr Val Ile Asp Asn Ala Lys Lys Ala 
            100                 105                 110         


Val Glu Ala Leu Cys Pro Lys Thr Val Ser Cys Ala Asp Ile Leu Ala 
        115                 120                 125             


Leu Ala Ala Arg Asp Ala Val Thr Leu Ser Gly Gly Pro Thr Trp Asn 
    130                 135                 140                 


Val Pro Lys Gly Arg Lys Asp Gly Arg Val Ser Lys Ala Thr Asp Thr 
145                 150                 155                 160 


Arg Gln Leu Pro Gly Pro Thr Phe Asn Ile Ser Gln Leu Gln Gln Ser 
                165                 170                 175     


Phe Ala Gln Arg Gly Leu Gly Thr Asp Asp Leu Val Ala Leu Ser Gly 
            180                 185                 190         


Gly His Thr Leu Gly Phe Ala His Cys Ser Ser Phe Gln Asn Arg Ile 
        195                 200                 205             


Asn Asn Phe Ser Ser Lys Gln Ser Val Asp Pro Thr Leu Gln Ser Ser 
    210                 215                 220                 


Phe Ala Ala Ser Leu Lys Ser Val Cys Pro Ala Lys Asn Thr Pro Lys 
225                 230                 235                 240 


Asn Ala Gly Ala Asn Leu Asp Ser Thr Pro Thr Thr Phe Asp Asn Arg 
                245                 250                 255     


Tyr Tyr Lys Leu Leu Leu Gln Gly Lys Ser Ile Phe Ser Ser Asp Gln 
            260                 265                 270         


Ala Leu Val Thr Met Gly Asn Thr Lys Ala Leu Val Thr Lys Tyr Ala 
        275                 280                 285             


Ser Ser Lys Gln Glu Phe Glu Lys Ala Phe Val Lys Ser Met Ile Lys 
    290                 295                 300                 


Met Ser Ser Ile Ser Gly Gly Gly Gln Glu Leu Ala Trp Cys Cys Asn 
305                 310                 315                 320 


Gln Thr Ser Tyr Lys Ile Gly Leu Arg Lys Leu Val Ser Lys Pro Glu 
                325                 330                 335     


Gly His Thr Lys Leu Leu Ile Ile Asp Thr Ala Thr Thr Asn Leu Lys 
            340                 345                 350         


Gly Val Glu Ser Lys Phe Ala Pro Ala Leu Phe Thr Leu Leu Cys Ile 
        355                 360                 365             


Gly His Thr Leu Arg Lys Leu Ala Ala Lys Ala Cys Cys Ser Asp Gly 
    370                 375                 380                 


Ser Thr Ser Cys Val Val Ala Lys Leu Trp Ile Leu Phe Trp Asn Glu 
385                 390                 395                 400 


Glu Gln 
        


<210>  34
<211>  137
<212>  PRT
<213>  Artemisia annua

<400>  34

Met Gly Ala His Thr Leu Gly Phe Ser His Cys Asp Gln Phe Leu Asn 
1               5                   10                  15      


Arg Ile Tyr Asn Phe Ser Lys Glu Asn Pro Val Asp Pro Thr Leu Ile 
            20                  25                  30          


Pro Ser Tyr Ala Ala Glu Leu Gln Gln Gln Cys Pro Lys Lys Asn Phe 
        35                  40                  45              


Asp Pro Asn Val Val Ile Pro Leu Asp Pro Ser Thr Thr Gly Ile Phe 
    50                  55                  60                  


Asp Asn Met Tyr Tyr Lys Asn Leu Gln Asn Gly Gln Gly Leu Leu Ala 
65                  70                  75                  80  


Ser Asp Gln Val Leu Phe Thr Asp Thr Arg Ser Lys Gln Thr Val Ile 
                85                  90                  95      


Ser Trp Ala Asn Ser Pro Lys Asp Phe Ser Asn Ala Phe Val Lys Ala 
            100                 105                 110         


Met Thr Lys Leu Gly Arg Val Gly Val Lys Thr Gly Gln Asn Gly Asn 
        115                 120                 125             


Ile Arg Arg Asp Cys Ser Ala Phe Asn 
    130                 135         


<210>  35
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  35

Met Asn Gln Lys Asn Ile Ile Ile Ala Phe Leu Val Ser Cys Ser Leu 
1               5                   10                  15      


Leu Leu Ala Asn Gly Gln Leu Asp Tyr Tyr Tyr Tyr Tyr Ser Phe Cys 
            20                  25                  30          


Pro Asn Leu Glu Met Ile Val Lys Tyr Gly Val Trp Ala Ala Met Lys 
        35                  40                  45              


Asn Asp Thr Arg Ile Ala Ala Ser Leu Leu Arg Leu His Phe His Asp 
    50                  55                  60                  


Cys Phe Val Asn Gly Cys Asp Gly Ser Ile Leu Leu Asp Asp Thr Lys 
65                  70                  75                  80  


Thr Phe Lys Gly Glu Gln Asn Ala Gly Pro Asn Ile Asn Ser Ala Arg 
                85                  90                  95      


Gly Tyr Glu Val Ile Asp Asn Ile Lys Ala Asp Val Glu Arg Ala Cys 
            100                 105                 110         


Pro Ser Thr Val Ser Cys Val Asp Ile Leu Thr Leu Ala Ala Arg Glu 
        115                 120                 125             


Ala Val Val Leu Ser Gly Gly Pro Asn Trp Pro Val Ala Leu Gly Arg 
    130                 135                 140                 


Arg Asp Gly Val Thr Ala Asn Leu Lys Ala Ala Asn Thr Asn Leu Pro 
145                 150                 155                 160 


Ser Pro Phe Glu Pro Leu Ala Asn Ile Thr Ala Lys Phe Ala Ala Val 
                165                 170                 175     


Gly Leu Asp Ile Arg Asp Val Val Val Leu Ser Gly Ala His Thr Ile 
            180                 185                 190         


Gly Leu Ala Gln Cys Phe Thr Phe Lys Asn Arg Leu Phe Asp Phe Lys 
        195                 200                 205             


Gly Thr Gly Gln Thr Asp Pro Asn Leu Asp Thr Ser Leu Ala Thr Ser 
    210                 215                 220                 


Leu Lys Thr Ser Cys Pro Asn Val Asp Ser Ser Asn Ser Asn Leu Asn 
225                 230                 235                 240 


Ser Leu Asp Leu Val Thr Thr Tyr Lys Phe Asp Asn Ala Tyr Tyr Lys 
                245                 250                 255     


Asn Leu Val Asn Asn Ala Gly Leu Leu Glu Ser Asp Gln Ala Leu Met 
            260                 265                 270         


Gly His Pro Leu Thr Ala Ser Met Val Lys Asp Tyr Ser Met Tyr Pro 
        275                 280                 285             


Tyr Leu Phe Tyr Lys Asp Phe Ala Thr Ser Met Val Lys Leu Gly Asn 
    290                 295                 300                 


Ile Gly Val Ile Thr Gly Gln Asn Gly Gln Val Arg Lys Lys Cys Gly 
305                 310                 315                 320 


Glu Val Asn Arg 
                


<210>  36
<211>  325
<212>  PRT
<213>  Artemisia annua

<400>  36

Met Ala Ile Gln Lys Gln Leu Ile Ala Val Leu Gln Leu Leu Leu Ile 
1               5                   10                  15      


Ala Leu Val Phe Asp Ile Ala Asn Gly Lys Gly Leu Glu Leu Gly Phe 
            20                  25                  30          


Tyr Arg Tyr Thr Cys Pro Arg Val Glu Ala Ile Val Arg Lys Thr Thr 
        35                  40                  45              


Ala Asn Tyr Ile His Arg Ala Pro Ser Leu Ala Ala Gly Leu Leu Arg 
    50                  55                  60                  


Met His Phe His Asp Cys Phe Val Arg Gly Cys Asp Gly Ser Val Leu 
65                  70                  75                  80  


Leu Asn Ser Thr Ala Asn Asn Gln Ala Glu Lys Glu Gly Ile Pro Asn 
                85                  90                  95      


Leu Thr Leu Arg Gly Phe Gln Val Val Asp Ala Ala Lys Thr Ala Leu 
            100                 105                 110         


Glu Ala Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Leu 
        115                 120                 125             


Val Ala Arg Asp Ala Ile Tyr Gln Ile Lys Gly Pro Phe Trp Pro Val 
    130                 135                 140                 


Pro Leu Gly Arg Arg Asp Gly Arg Val Ser Ile Ala Asn Glu Ala Leu 
145                 150                 155                 160 


Thr Ser Leu Pro Ser Pro Phe Ala Asn Ile Thr Gln Leu Lys Ala Asn 
                165                 170                 175     


Phe Ala Ser Lys Gly Leu Asn Thr Lys Asp Leu Val Val Leu Ser Gly 
            180                 185                 190         


Gly His Thr Val Gly Val Ser His Cys Pro Val Ile Val Asn Arg Leu 
        195                 200                 205             


Tyr Asn Phe Thr Gly Lys Gly Asp Thr Asp Pro Ser Leu Asp Pro Lys 
    210                 215                 220                 


Phe Ile Pro Gln Leu Lys Ser Ile Cys Ser Pro Thr Asp Thr Thr Ser 
225                 230                 235                 240 


Val Leu Ala Met Asp Arg Thr Pro Arg Ser Phe Asp Glu Asp Tyr Tyr 
                245                 250                 255     


Thr Val Val Leu Arg Lys Arg Gly Leu Phe Gln Ser Asp Ala Ala Leu 
            260                 265                 270         


Leu Asn Asp Lys Gln Thr Ser Ala Tyr Val Lys Leu Gln Ser Lys Ser 
        275                 280                 285             


Phe Gly Tyr Thr Phe Phe Asn Asp Phe Ser Lys Ser Met Val Lys Met 
    290                 295                 300                 


Gly Lys Ile Gly Val Leu Thr Gly Ser Ala Gly Glu Ile Arg Arg Thr 
305                 310                 315                 320 


Cys Ala Leu Val Asn 
                325 


<210>  37
<211>  338
<212>  PRT
<213>  Artemisia annua

<400>  37

Met Val Ser Cys Asn Leu Ser Ser Leu Leu Leu Gly Val Phe Val Leu 
1               5                   10                  15      


Ala Thr Ile His Ser Ser Leu Ser Ile Thr Leu Ser Pro Asn Tyr Tyr 
            20                  25                  30          


Asp Gln Thr Cys Pro Asn Val Glu Ala Ala Val Thr Ser Ala Val Lys 
        35                  40                  45              


Lys Ala Met Leu Asn Asp Arg Thr Val Pro Ala Ala Leu Leu Arg Met 
    50                  55                  60                  


Gln Phe His Asp Cys Phe Ile Arg Gly Cys Asp Gly Ser Val Leu Leu 
65                  70                  75                  80  


Asn Ser Thr Lys Asn Asn Gln Ala Glu Lys Asp Gly Pro Pro Asn Ile 
                85                  90                  95      


Ser Leu His Ala Phe Tyr Val Ile Asp Asn Ala Lys Lys Ala Leu Glu 
            100                 105                 110         


Ala Met Cys Pro Gly Thr Val Ser Cys Ala Asp Ile Ile Ala Leu Ala 
        115                 120                 125             


Ala Arg Asp Ala Val His Leu Ser Gly Gly Pro Ser Trp Val Val Pro 
    130                 135                 140                 


Lys Gly Arg Lys Asp Gly Arg Ile Ser Lys Ala Thr Glu Thr Arg Gln 
145                 150                 155                 160 


Leu Pro Ala Pro Thr Phe Asn Ile Ser Gln Leu Gln Gln Ser Phe Ser 
                165                 170                 175     


Gln Arg Gly Leu Asp Ile Asn Asp Leu Val Ala Leu Ser Gly Gly His 
            180                 185                 190         


Thr Leu Gly Phe Ala His Cys Ser Ser Phe Gln Asn Arg Ile His Asn 
        195                 200                 205             


Phe Ala Thr Thr Gln Asp Val Asp Pro Ser Leu Gln Gln Ala Phe Ala 
    210                 215                 220                 


Ala Ser Leu Arg Ser Val Cys Pro Met His Asn Lys Val Asn Ser Ala 
225                 230                 235                 240 


Gly Ala Asn Leu Asp Ser Thr Pro Thr Ile Phe Asp Asn Ser Tyr Tyr 
                245                 250                 255     


Lys Leu Leu Leu Glu Gly Glu Ser Ile Phe Ser Ser Asp Gln Ala Leu 
            260                 265                 270         


Leu Thr Asn Pro Thr Thr Gln Lys Leu Val Thr Lys Tyr Ala Tyr Ser 
        275                 280                 285             


Arg Glu Glu Phe Glu Lys Ala Phe Val Glu Ser Met Ile Lys Met Ser 
    290                 295                 300                 


Ser Ile Thr Gly Gly Gln Glu Lys Thr Asp Val Thr Arg Phe Ser Ser 
305                 310                 315                 320 


Thr Pro Thr Arg Ala Glu Cys Leu Ser Ser Arg Asn Leu Glu Thr Lys 
                325                 330                 335     


Thr Ser 
        


<210>  38
<211>  328
<212>  PRT
<213>  Artemisia annua

<400>  38

Met Lys Ser Leu Ser Thr Asn Gly Phe Ala Trp Phe Ile Thr Ile Ser 
1               5                   10                  15      


Met Leu Cys Leu Leu Ala Asn Ser Gln Leu Thr Thr Asn Phe Tyr Ser 
            20                  25                  30          


Asn Ser Cys Pro Asn Leu Phe Ser Ile Val Arg Lys Gln Val Leu Asn 
        35                  40                  45              


Ala Val Lys Thr Glu Thr Arg Met Ala Ala Ser Leu Leu Arg Leu His 
    50                  55                  60                  


Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Val Leu Leu Asp 
65                  70                  75                  80  


Gly Ser Asp Gly Glu Lys Thr Ala Leu Pro Asn Asn Asn Ser Ala Arg 
                85                  90                  95      


Gly Phe Glu Val Val Asp Ala Ile Lys Thr Ala Val Glu Ser Ser Cys 
            100                 105                 110         


Ser Gly Ile Val Ser Cys Ala Asp Ile Leu Ala Ile Ala Ala Arg Asp 
        115                 120                 125             


Ser Val Leu Leu Ser Gly Gly Pro Ser Trp Lys Val Leu Leu Gly Arg 
    130                 135                 140                 


Arg Asp Gly Leu Val Ala Asn Gln Thr Gly Ala Asn Ser Met Leu Pro 
145                 150                 155                 160 


Gly Pro Phe Glu Pro Val Asp Asn Ile Thr Leu Lys Phe Gln Ala Val 
                165                 170                 175     


Gly Leu Asn Leu Thr Asp Val Val Ser Leu Ser Gly Ala His Thr Ile 
            180                 185                 190         


Gly Arg Ala Ser Cys Ala Thr Phe Gly Asn Arg Leu Phe Asn Phe Ser 
        195                 200                 205             


Gly Thr Asn Ala Pro Asp Ser Thr Leu Leu Asp Ala Asn Met Val Ser 
    210                 215                 220                 


Gly Leu Gln Asn Leu Cys Pro Val Asn Gly Asp Ser Ser Arg Val Thr 
225                 230                 235                 240 


Asp Leu Asp Trp Asn Ser Thr Asp Leu Phe Asp Asn His Tyr Phe Gln 
                245                 250                 255     


Asn Leu Ile Asn Gly Arg Gly Ile Leu Glu Ser Asp Gln Phe Leu Tyr 
            260                 265                 270         


Ser Ser Asp Gln Ala Val Ser Thr Thr Arg Ser Ile Val Glu Leu Tyr 
        275                 280                 285             


Ser Asn Asn Thr Lys Leu Phe Phe Asn Asp Phe Ala Asn Ser Met Ile 
    290                 295                 300                 


Lys Met Gly Asn Ile Gln Pro Leu Thr Gly Ser Ala Gly Glu Ile Arg 
305                 310                 315                 320 


Lys Asn Cys Arg Val Val Asn Ser 
                325             


<210>  39
<211>  325
<212>  PRT
<213>  Artemisia annua

<400>  39

Met Ala Ile Gln Lys His Asn Thr Leu Gly Leu Arg Phe Leu Leu Val 
1               5                   10                  15      


Ala Leu Leu Leu Asn Ile Ala Asn Gly Asn Asp Leu Lys Leu Gly Phe 
            20                  25                  30          


Tyr Lys Lys Thr Cys Pro Arg Ala Glu Ala Ile Val Lys Arg Thr Thr 
        35                  40                  45              


Ala Asn Phe Ile Ser Arg Ala Pro Ser Leu Ala Ala Pro Leu Leu Arg 
    50                  55                  60                  


Met His Phe His Asp Cys Phe Val Arg Gly Cys Asp Gly Ser Val Leu 
65                  70                  75                  80  


Leu Asn Ser Thr Lys Asn Asn Gln Ala Glu Lys Ala Gly Ile Pro Asn 
                85                  90                  95      


Leu Ser Leu Arg Gly Phe Gln Val Ile Asp Ala Ala Lys Thr Ala Val 
            100                 105                 110         


Glu Ala Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Leu 
        115                 120                 125             


Val Ala Arg Asp Ser Ile Gln Gln Ile Lys Gly Pro Tyr Trp Pro Val 
    130                 135                 140                 


Pro Leu Gly Arg Arg Asp Gly Arg Val Ser Ile Ala Ser Glu Ser Phe 
145                 150                 155                 160 


Thr Leu Pro Ala Pro Phe Ala Asn Ile Thr Thr Leu Lys Ser Gln Phe 
                165                 170                 175     


Lys Ser Arg Gly Leu Ser Val Lys Asp Leu Val Val Leu Ser Gly Gly 
            180                 185                 190         


His Thr Val Gly Val Ser His Cys Ser Thr Ile Ala Ser Arg Leu Tyr 
        195                 200                 205             


Asn Phe Thr Gly Lys Gly Asp Thr Asp Pro Thr Leu Asp Pro Lys Tyr 
    210                 215                 220                 


Val Pro His Leu Lys Ser Lys Cys Lys Pro Thr Asp Thr Thr Thr Leu 
225                 230                 235                 240 


Leu Glu Met Asp Pro Gly Ser Val Lys Thr Phe Asp Glu Asp Tyr Tyr 
                245                 250                 255     


Thr Ile Val Ser Lys Arg Arg Gly Leu Phe Glu Ser Asp Ala Ala Leu 
            260                 265                 270         


Leu Asn Asp Lys Gln Thr Ser Ala Tyr Val Lys Leu Gln Ala Lys Ser 
        275                 280                 285             


His Gly Ala Thr Phe Phe Lys Asp Phe Ser Asp Ser Met Val Lys Met 
    290                 295                 300                 


Gly Lys Ile Gly Val Leu Thr Gly Lys Asn Gly Glu Ile Arg Lys His 
305                 310                 315                 320 


Cys Ala Leu Ile Asn 
                325 


<210>  40
<211>  331
<212>  PRT
<213>  Artemisia annua

<400>  40

Met Glu Gly Ser Ser Leu Thr Lys Thr Leu Val Met Leu Val Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Thr Thr Leu Ala Leu Gly Gln Ser Val Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Thr Arg Val Gly Phe Tyr Ser Ser Thr Cys Arg Asn Val 
        35                  40                  45              


Glu Ser Ile Val Gln Ser Ala Val Arg Thr Ala Val Gln Ala Asn Pro 
    50                  55                  60                  


Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe His Asp Cys Phe Val 
65                  70                  75                  80  


Asn Gly Cys Asp Ala Ser Ile Leu Ile Asn Gly Thr Asn Thr Glu Lys 
                85                  90                  95      


Ser Ala Arg Pro Asn Ser Leu Leu Arg Gly Phe Glu Val Ile Asp Ala 
            100                 105                 110         


Ala Lys Ser Arg Leu Glu Thr Ser Cys Pro Gly Val Val Ser Cys Ala 
        115                 120                 125             


Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val Leu Thr Gly Gly 
    130                 135                 140                 


Arg Ser Trp Pro Val Pro Leu Gly Arg Arg Asp Gly Leu Val Ser Gln 
145                 150                 155                 160 


Ala Ser Asp Thr Ala Asn Leu Pro Ala Phe Asn Asp Pro Met Thr Val 
                165                 170                 175     


Gln Ile Gln Lys Phe Ala Asp Lys Gly Leu Asn Ile Gln Asp Leu Val 
            180                 185                 190         


Thr Leu Val Gly Gly His Thr Ile Gly Thr Ala Ala Cys Ala Leu Phe 
        195                 200                 205             


Ser Tyr Arg Leu Tyr Asn Phe Asn Asn Thr Asn Ala Pro Asp Pro Asp 
    210                 215                 220                 


Ile Asn Pro Ala Phe Leu Pro Thr Leu Arg Ala Leu Cys Pro Asn Gly 
225                 230                 235                 240 


Gly Asp Gly Ser Arg Arg Val Ala Leu Asp Thr Asp Ser Val Asn Ser 
                245                 250                 255     


Phe Gly Ser Ser Tyr Tyr Asn Asn Leu Arg Asn Gly Arg Gly Val Ile 
            260                 265                 270         


Glu Ser Asp Ala Lys Leu Trp Ser Asp Gln Arg Thr Gln Arg Phe Val 
        275                 280                 285             


Gln Gly Phe Leu Gly Ala Asn Gly Ala Arg Phe Asn Ala Glu Phe Gly 
    290                 295                 300                 


Arg Ala Met Val Arg Leu Gly Asn Val Glu Val Lys Thr Gly Thr Gln 
305                 310                 315                 320 


Gly Gln Ile Arg Arg Val Cys Thr Ala Thr Asn 
                325                 330     


<210>  41
<211>  359
<212>  PRT
<213>  Artemisia annua

<400>  41

Met Ala Ser Ser Ser Ser Ala Ser Leu Phe Leu Ile Leu Ser Ser Leu 
1               5                   10                  15      


Leu Ile Phe Ser Ser Leu Leu Tyr Val Ser Glu Ala Asp Tyr Ser Ala 
            20                  25                  30          


Pro Ile Val Lys Gly Leu Ser Trp Asp Tyr His His Lys Thr Cys His 
        35                  40                  45              


Lys Val Glu Lys Ile Val Arg Lys His Leu Lys Lys Val Phe Lys Glu 
    50                  55                  60                  


Asp Ile Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His Asp Cys 
65                  70                  75                  80  


Phe Val Gln Gly Cys Asp Gly Ser Val Leu Leu Asp Gly Ser His Ser 
                85                  90                  95      


Gly Pro Ser Glu Gln Thr Ala Pro Pro Asn Gln Ser Leu Arg Lys Gln 
            100                 105                 110         


Ala Phe Thr Ile Ile Glu Asp Leu Arg Gly Leu Ile His Arg Glu Cys 
        115                 120                 125             


Gly Arg Val Val Ser Cys Ser Asp Ile Val Ala Ile Ala Ala Arg Asp 
    130                 135                 140                 


Ala Val His Leu Ser Gly Gly Pro Asp Tyr Asp Val Pro Leu Gly Arg 
145                 150                 155                 160 


Lys Asp Gly Leu Thr Phe Ala Thr Glu Asn Ala Thr Leu Ala Asn Leu 
                165                 170                 175     


Pro Ala Pro Thr Ser Asn Ala Ser Thr Ile Leu Ser Ala Leu Ala Thr 
            180                 185                 190         


Lys Asn Leu Thr Pro Thr Asp Val Val Ala Leu Ser Gly Gly His Thr 
        195                 200                 205             


Ile Gly Ile Ser His Cys Thr Ser Phe Thr Pro Arg Leu Tyr Pro Thr 
    210                 215                 220                 


Gln Asp Pro Thr Met Glu Lys Thr Phe Ala His Gly Leu Lys Glu Val 
225                 230                 235                 240 


Cys Pro Thr Asn Thr Thr Asp Ala Thr Thr Val Met Asp Ile Leu Ser 
                245                 250                 255     


Pro Ile Lys Phe Asp Asn Lys Tyr Phe Val Asp Leu Met Asn Arg Gln 
            260                 265                 270         


Gly Leu Phe Thr Ser Asp Gln Asp Leu Tyr Thr His Lys Glu Thr Lys 
        275                 280                 285             


Pro Ile Val Glu Ser Phe Ala His Asp Glu Lys Leu Phe Phe Glu Lys 
    290                 295                 300                 


Phe Val Lys Ala Met Ile Lys Met Gly Gln Met Glu Val Leu Thr Gly 
305                 310                 315                 320 


Gly Lys Gly Glu Ile Arg Ala His Cys Ser Ile Arg Asn Pro Asp Asn 
                325                 330                 335     


Lys Ala Tyr Phe Ser Tyr Leu Val Glu Glu Asp Glu Gln Ser Tyr Leu 
            340                 345                 350         


Glu Ser Arg Ala Glu Leu Arg 
        355                 


<210>  42
<211>  350
<212>  PRT
<213>  Artemisia annua

<400>  42

Met Ala Ser Asn Met Ala Leu Leu Ala Ser Val Leu Val Val Met Leu 
1               5                   10                  15      


Met His Leu Gln Ser Leu Glu Ala Gln Gln Pro Pro Leu Val Lys Gly 
            20                  25                  30          


Leu Ser Trp Lys Tyr Tyr Glu Ser Ser Cys Pro Lys Leu Glu Ser Ile 
        35                  40                  45              


Ile Arg Lys Gln Leu Glu Lys Val Ile Lys Lys Asp Val Gly Leu Ala 
    50                  55                  60                  


Ala Ala Leu Leu Arg Met His Phe His Asp Cys Phe Val Gln Gly Cys 
65                  70                  75                  80  


Asp Gly Ser Val Leu Leu Asp Gly Ser Ala Ser Gly Pro Val Asp Ser 
                85                  90                  95      


Glu Lys Thr Ala Pro Pro Asn Leu Ser Leu Arg Gly Phe Asp Val Ile 
            100                 105                 110         


Glu Asp Leu Arg Arg Arg Val His Lys Glu Cys Gly Ala Gly Ser Val 
        115                 120                 125             


Ser Cys Ala Asp Ile Thr Ala Ile Val Ala Arg Asp Ser Ile Val Leu 
    130                 135                 140                 


Thr Gly Gly Pro Thr Tyr Ser Val Pro Leu Gly Arg Arg Asp Gly Leu 
145                 150                 155                 160 


Ser Phe Ala Thr Arg Asp Ala Thr Leu Ala Asn Leu Pro Ser Pro Phe 
                165                 170                 175     


Val Pro Thr Asp Asn Leu Leu Arg Thr Leu Ala Ala Lys Asn Phe Asp 
            180                 185                 190         


Ala Thr Asp Ala Val Ala Leu Ser Gly Ala His Thr Ile Gly Ile Ala 
        195                 200                 205             


His Cys Ser Ser Phe Thr Arg Arg Leu Tyr Pro Thr Gln Asp Thr Thr 
    210                 215                 220                 


Leu Asp Lys Thr Phe Ala Thr Thr Leu Lys Gly Val Cys Pro Ala Pro 
225                 230                 235                 240 


Asp Thr Asn Ala Ser Thr Phe Met Asp Leu Arg Ser Pro Asn Val Phe 
                245                 250                 255     


Asp Asn Lys Tyr Phe Val Asp Leu Met Asn Lys Gln Gly Val Leu Thr 
            260                 265                 270         


Ser Asp Gln Asp Leu Tyr Thr Asp Lys Arg Thr Arg Asn Ile Val Thr 
        275                 280                 285             


Ser Phe Ala Val Asn Gln Thr Leu Phe Phe Glu Lys Phe Val Asn Val 
    290                 295                 300                 


Met Ile Lys Met Gly Gln Met Glu Val Leu Thr Gly Thr Gln Gly Glu 
305                 310                 315                 320 


Val Arg Asn Lys Cys Ser Val Thr Asn Ser Asn Asp Leu Leu Ile Ser 
                325                 330                 335     


Ser Val Val Glu Gly Asp Asn Met Asp Ser Val Glu Ser Phe 
            340                 345                 350 


<210>  43
<211>  352
<212>  PRT
<213>  Artemisia annua

<400>  43

Met Ala Phe Leu Lys Ala Ser Cys Leu Pro Thr Leu Ile Phe Val Leu 
1               5                   10                  15      


Leu Leu Cys Asn Ile Arg Ala Ser Asp Ala Gln Thr Pro Pro Leu Ala 
            20                  25                  30          


Glu Gly Leu Ser Tyr Thr Phe His Gln Ser Ser Cys Pro Gln Leu Glu 
        35                  40                  45              


Ser Ile Val Arg Ser Gln Leu Gln Thr Glu Leu Ala Ala Asp Ile Gly 
    50                  55                  60                  


Gln Ala Ala Gly Leu Leu Arg Leu His Phe His Asp Cys Phe Val Leu 
65                  70                  75                  80  


Gly Cys Asp Gly Ser Val Leu Leu Asn Gly Ser Ala Ser Gly Pro Ser 
                85                  90                  95      


Glu Gln Ser Ala Pro Pro Asn Leu Thr Leu Arg Pro Arg Ala Phe Val 
            100                 105                 110         


Ile Ile Glu Asn Ile Arg Ser Leu Val His Ala Ala Cys Asn Ala Thr 
        115                 120                 125             


Val Ser Cys Ser Asp Ile Thr Ala Leu Ala Ala Arg Asp Ala Val Val 
    130                 135                 140                 


Leu Ser Gly Gly Pro Asn Tyr Ser Val Pro Leu Gly Arg Arg Asp Gly 
145                 150                 155                 160 


Val Ser Phe Ala Ser Arg Glu Asp Thr Leu Ala Asn Leu Pro Pro Phe 
                165                 170                 175     


Asn Ala Thr Ala Ala Asn Leu Thr Ala Ser Leu Ala Leu Lys Gly Phe 
            180                 185                 190         


Asp Val Thr Asp Val Val Ala Leu Ser Gly Ala His Thr Ile Gly Arg 
        195                 200                 205             


Ala Glu Cys Gly Ser Phe Glu Arg Arg Met Phe Pro Thr Pro Asp Pro 
    210                 215                 220                 


Thr Met Asp Gln Ile Phe Tyr Thr Asn Leu Leu Gln Thr Cys Pro Ile 
225                 230                 235                 240 


Leu Asn Thr Thr Asn Thr Thr Ile Met Asp Ile Gln Thr Pro Asn Ala 
                245                 250                 255     


Phe Asp Asn Arg Tyr Tyr Val Asn Leu Met Asn Arg Gln Gly Leu Phe 
            260                 265                 270         


Thr Ser Asp Gln Asp Leu Phe Thr Asp Asn Thr Thr Ser Gly Ile Val 
        275                 280                 285             


Thr Ser Phe Ala Asn Asn Gln Thr Leu Phe Phe Glu Asn Phe Val Ile 
    290                 295                 300                 


Ala Met Ile Lys Met Gly Gln Leu Asn Val Thr Thr Gly Thr Gln Gly 
305                 310                 315                 320 


Glu Ile Arg Ala Asn Cys Ser Phe Val Asn Ser Asn Asn Thr Leu Ser 
                325                 330                 335     


Leu Pro Ala Met Glu Asn Ala Asn Asp Asn Gln Lys Ile Ala Ser Tyr 
            340                 345                 350         


<210>  44
<211>  350
<212>  PRT
<213>  Artemisia annua

<400>  44

Met Ala Ser Lys Met Thr Leu Leu Ala Ser Val Leu Val Val Met Leu 
1               5                   10                  15      


Met His Leu Gln Ser Leu Glu Ala Gln Gln Pro Asn Leu Val Lys Gly 
            20                  25                  30          


Leu Ser Trp Lys Tyr Tyr Glu Ser Ser Cys Pro Lys Leu Glu Ser Ile 
        35                  40                  45              


Ile Arg Lys Gln Leu Glu Lys Val Ile Lys Lys Asp Val Gly Leu Ala 
    50                  55                  60                  


Ala Ala Leu Leu Arg Met His Phe His Asp Cys Phe Val Gln Gly Cys 
65                  70                  75                  80  


Asp Gly Ser Val Leu Leu Asp Gly Ser Ala Ser Gly Pro Val Asp Ser 
                85                  90                  95      


Glu Lys Thr Ala Pro Pro Asn Leu Ser Leu Arg Gly Phe Asp Val Ile 
            100                 105                 110         


Glu Asp Leu Arg Arg Arg Val His Lys Glu Cys Gly Ala Gly Ser Val 
        115                 120                 125             


Ser Cys Ala Asp Ile Thr Ala Ile Val Ala Arg Asp Ser Ile Val Leu 
    130                 135                 140                 


Thr Gly Gly Pro Thr Tyr Ser Val Pro Leu Gly Arg Arg Asp Gly Leu 
145                 150                 155                 160 


Ser Phe Ala Thr Arg Asp Ala Thr Leu Ala Asn Leu Pro Ser Pro Phe 
                165                 170                 175     


Val Pro Thr Asp Asn Leu Leu Arg Thr Leu Ala Ala Lys Asn Phe Asp 
            180                 185                 190         


Ala Thr Asp Ala Val Ala Leu Ser Gly Ala His Thr Ile Gly Ile Ala 
        195                 200                 205             


His Cys Ser Ser Phe Thr Arg Arg Leu Tyr Pro Thr Gln Asp Thr Thr 
    210                 215                 220                 


Leu Asp Lys Thr Phe Ala Thr Thr Leu Lys Gly Val Cys Pro Ala Pro 
225                 230                 235                 240 


Asn Thr Asn Ala Ser Thr Phe Met Asp Leu Arg Ser Pro Asn Val Phe 
                245                 250                 255     


Asp Asn Lys Tyr Phe Val Asp Leu Met Asn Lys Gln Gly Leu Leu Thr 
            260                 265                 270         


Ser Asp Gln Asp Leu Tyr Thr Asp Lys Arg Thr Arg Asn Ile Val Thr 
        275                 280                 285             


Ser Phe Ala Val Asn Gln Thr Leu Phe Phe Glu Lys Phe Val Asn Val 
    290                 295                 300                 


Met Ile Lys Met Gly Gln Met Glu Val Leu Thr Gly Thr Gln Gly Glu 
305                 310                 315                 320 


Val Arg Asn Lys Cys Ser Val Gln Asn Ser Asn Asp Leu Leu Ile Ser 
                325                 330                 335     


Ser Val Val Glu Gly Asp Asn Met Asp Ser Val Glu Ser Phe 
            340                 345                 350 


<210>  45
<211>  373
<212>  PRT
<213>  Artemisia annua

<400>  45

Met Ser Ser Ile Ile Leu Asn His Val Cys Asn Ser Ile Phe Ile Leu 
1               5                   10                  15      


Val Leu Leu Gly Cys Val Phe Asn Ser Lys Ala His Leu Gln Val Gly 
            20                  25                  30          


Phe Tyr Ser Glu Ser Cys Ser Ile Ala Glu Ser Ile Val Lys Asp Glu 
        35                  40                  45              


Val Tyr Lys Ala Tyr Ser Glu Asp Ser Gly Leu Ala Ala Gly Val Val 
    50                  55                  60                  


Arg Ile His Phe His Asp Cys Phe Val Arg Gly Cys Asp Gly Ser Val 
65                  70                  75                  80  


Leu Ile Asp Ser Thr Pro Ser Asn Thr Ala Glu Lys Asp Ser Pro Val 
                85                  90                  95      


Asn Asn Pro Ser Leu Arg Gly Phe Asn Val Ile Asp Asp Ala Lys Ala 
            100                 105                 110         


Arg Leu Glu Glu Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Val 
        115                 120                 125             


Ala Phe Ala Ala Arg Asp Ala Ile His Ile Thr Gly Gly Tyr Gly Tyr 
    130                 135                 140                 


Asp Val Pro Ala Gly Arg Arg Asp Gly Val Val Ser Leu Leu Ala Glu 
145                 150                 155                 160 


Thr Ile Gly Leu Pro Pro Pro Thr Phe Asn Leu Ser Gln Leu Thr Gln 
                165                 170                 175     


Met Phe Glu Ser Asn Gly Leu Thr Gln Glu Glu Met Thr Gly Gly Tyr 
            180                 185                 190         


Gly Tyr Asp Val Pro Ala Gly Arg Arg Asp Gly Val Val Ser Leu Leu 
        195                 200                 205             


Ala Glu Thr Ile Gly Leu Pro Pro Pro Thr Phe Asn Leu Ser Gln Leu 
    210                 215                 220                 


Thr Gln Met Phe Glu Ser Asn Gly Leu Thr Gln Glu Glu Met Val Thr 
225                 230                 235                 240 


Leu Ser Gly Thr His Thr Ile Gly Arg Ala His Cys Thr Ser Phe Ala 
                245                 250                 255     


Asp Arg Leu Val Asn Gln Asp Pro Thr Leu Asp Ala Ser Tyr Ala Ser 
            260                 265                 270         


Ser Leu Lys Gln Gln Cys Pro Asn Gly Gly Asn Asp Val Asn Leu Val 
        275                 280                 285             


Val Pro Met Asp Pro Ser Ser Pro Ala Val Thr Asp Thr Ala Tyr Tyr 
    290                 295                 300                 


Val Asp Val Leu His Asn Arg Gly Leu Phe Thr Ser Asp Gln Thr Leu 
305                 310                 315                 320 


Leu Thr Ser Ala Ser Thr Ala His Gln Val Tyr Gln Asn Ala Ile Tyr 
                325                 330                 335     


Pro Ser Leu Trp Lys Ser Lys Leu Ala Asp Ala Met Val Lys Met Gly 
            340                 345                 350         


Lys Ile Gly Val Leu Thr Gly Asp Gln Gly Glu Ile Arg Leu Asn Cys 
        355                 360                 365             


Arg Val Ile Asn Lys 
    370             


<210>  46
<211>  330
<212>  PRT
<213>  Artemisia annua

<400>  46

Met Ser His Asn Leu Phe Leu Leu Pro Leu Val Phe Leu Ala Leu Phe 
1               5                   10                  15      


Pro Val Val Ala Pro Gln Leu Arg Gln Gly Tyr Tyr Ser Asp Thr Cys 
            20                  25                  30          


Pro Asn Ala Glu Met Thr Val Thr Ala Arg Met Gln Lys Ala Met Ile 
        35                  40                  45              


Lys Glu Pro Arg Ser Gly Ala Ser Val Met Arg Phe Gln Phe His Asp 
    50                  55                  60                  


Cys Phe Val Asn Gly Cys Asp Ala Ser Leu Leu Leu Asp Asp Thr Pro 
65                  70                  75                  80  


Thr Met Leu Gly Glu Lys Leu Ser Leu Ser Asn Ile Asp Ser Leu Arg 
                85                  90                  95      


Ser Tyr Glu Val Val Asp Glu Ile Lys Glu Ala Leu Glu Arg Ile Cys 
            100                 105                 110         


Pro Met Thr Val Ser Cys Ala Asp Ile Ile Ile Met Ala Ser Arg Asp 
        115                 120                 125             


Ala Val Ala Leu Ser Ala Gly Pro Phe Trp Glu Val Lys Leu Gly Arg 
    130                 135                 140                 


Leu Asp Ser Leu Ser Ala Ser Gln Lys Ala Ser Asp Asp Ile Met Pro 
145                 150                 155                 160 


Ser Pro Arg Ser Asn Ala Ser Met Leu Ile Asp Leu Phe Ala Arg Phe 
                165                 170                 175     


Asn Leu Ser Val Gln Asp Leu Val Ala Leu Ser Gly Ser His Ser Ile 
            180                 185                 190         


Gly Asn Ala Arg Cys Phe Ser Ile Val His Arg Ile Tyr Asn Gln Ser 
        195                 200                 205             


Asp Asp Gly Lys Pro Asp Pro Ser Ile Glu Pro Gly Phe Leu Lys Lys 
    210                 215                 220                 


Leu Gln Glu Leu Cys Pro Leu Gly Gly Asp Glu Asn Val Ile Gly Asp 
225                 230                 235                 240 


Leu Asp Phe Thr Pro Arg Thr Phe Asp Asn Glu Tyr Phe Lys Asp Leu 
                245                 250                 255     


Val Asn Gly Lys Gly Phe Leu Asn Ser Asp Glu Thr Leu Phe Thr Asn 
            260                 265                 270         


Pro Gln Thr Arg Glu Tyr Val Gln Arg Tyr Ser Glu Asp Gln Ser Ala 
        275                 280                 285             


Phe Leu Lys Asp Phe Val Glu Gly Met Ile Lys Leu Gly Asp Leu Gln 
    290                 295                 300                 


Ser Gly Arg Pro Gly Glu Ile Arg Lys Asn Cys Arg Val Val Asn Ser 
305                 310                 315                 320 


Pro Pro Pro Ala Asn Val Met Val Arg Lys 
                325                 330 


<210>  47
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  47

Met Lys Gly Val Cys Leu Ile Phe Phe Val Leu Ala Ile Leu Gly Thr 
1               5                   10                  15      


Val Gln Gly Asp Leu Lys Met Gly Phe Tyr Ser Arg Ser Cys Pro Lys 
            20                  25                  30          


Ala Glu Lys Ile Ile Gln Asp Tyr Val Asn Gln His Ile Pro Arg Val 
        35                  40                  45              


Pro Ser Leu Gly Ala Ala Leu Ile Arg Met His Phe His Asp Cys Phe 
    50                  55                  60                  


Val Arg Gly Cys Asp Gly Ser Val Leu Leu Asn Ser Thr Ala Ser Ser 
65                  70                  75                  80  


Gly Asn Gln Thr Glu Lys Thr Ala Ile Pro Asn Arg Thr Val Thr Gly 
                85                  90                  95      


Phe Asp Phe Ile Asp Lys Leu Lys Ser Leu Leu Glu Ser Ala Cys Pro 
            100                 105                 110         


Gly Ile Val Ser Cys Ala Asp Ile Ile Ala Leu Ala Thr Arg Asp Thr 
        115                 120                 125             


Ile Val Val Thr Gly Gly Pro Thr Trp Arg Val Pro Thr Gly Arg Arg 
    130                 135                 140                 


Asp Gly Thr Val Ser Ile Ala Ser Glu Ala Leu Ala Gln Ile Pro Ala 
145                 150                 155                 160 


Pro Ser Asp Asn Ile Thr Leu Leu Gln Gln Ser Phe Ala Asn Lys Ser 
                165                 170                 175     


Leu Asp Leu Lys Asp Leu Val Leu Leu Ser Gly Ala His Thr Ile Gly 
            180                 185                 190         


Ile Ala Arg Cys Pro Ser Phe Ser Asn Arg Leu Tyr Asn Phe Ser Ala 
        195                 200                 205             


Ser Ser Ser Thr Asp Pro Ser Leu Asp Ser Glu Tyr Ala Asp Val Leu 
    210                 215                 220                 


Arg Ala Ser Lys Cys Arg Thr Pro Asn Asp Asn Thr Thr Leu Val Glu 
225                 230                 235                 240 


Met Asp Pro Gly Ser Arg Arg Thr Phe Asp Leu Ser Tyr Tyr Arg Leu 
                245                 250                 255     


Leu Leu Lys Arg Arg Gly Leu Phe Glu Ser Asp Ser Ala Leu Thr Lys 
            260                 265                 270         


Ser Ser Gln Thr Leu Arg Tyr Val Asn Lys Ile Leu Gln Gly Ser Leu 
        275                 280                 285             


Asp Asn Phe Tyr Lys Glu Phe Gly Leu Ala Met Glu Lys Met Gly Arg 
    290                 295                 300                 


Ile Asp Val Lys Thr Gly Ser Ser Gly Glu Ile Arg Arg Asn Cys Ala 
305                 310                 315                 320 


Phe Val Asn Ser 
                


<210>  48
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  48

Met Lys Gly Val Cys Leu Ile Phe Phe Val Leu Ala Ile Leu Gly Ser 
1               5                   10                  15      


Val Gln Gly Asp Leu Lys Met Gly Phe Tyr Ser Arg Ser Cys Pro Lys 
            20                  25                  30          


Ala Glu Lys Ile Ile Gln Asp Tyr Val Asn Gln His Ile Pro Arg Val 
        35                  40                  45              


Pro Ser Leu Gly Ala Ala Leu Ile Arg Met His Phe His Asp Cys Phe 
    50                  55                  60                  


Val Arg Gly Cys Asp Gly Ser Val Leu Leu Asn Ser Thr Ala Ser Ser 
65                  70                  75                  80  


Gly Asn Gln Thr Glu Lys Thr Ala Ile Pro Asn Arg Thr Val Thr Gly 
                85                  90                  95      


Phe Asp Phe Ile Asp Arg Leu Lys Ser Leu Leu Glu Ser Ala Cys Pro 
            100                 105                 110         


Gly Ile Val Ser Cys Ala Asp Ile Ile Ala Leu Ala Thr Arg Asp Thr 
        115                 120                 125             


Ile Val Val Thr Gly Gly Pro Ser Trp Arg Val Pro Thr Gly Arg Arg 
    130                 135                 140                 


Asp Gly Thr Val Ser Ile Ala Ser Glu Ala Leu Ala Gln Ile Pro Ala 
145                 150                 155                 160 


Pro Ser Asp Asn Ile Thr Leu Leu Gln Gln Ser Phe Ala Asn Lys Ser 
                165                 170                 175     


Leu Asp Leu Lys Asp Leu Val Leu Leu Ser Gly Ala His Thr Ile Gly 
            180                 185                 190         


Ile Ala Arg Cys Pro Ser Phe Ser Asn Arg Leu Tyr Asn Phe Ser Ala 
        195                 200                 205             


Ser Ser Ser Thr Asp Pro Ser Leu Asp Ser Glu Tyr Ala Asp Val Leu 
    210                 215                 220                 


Arg Ala Ser Lys Cys Arg Thr Pro Asn Asp Asn Thr Thr Leu Val Glu 
225                 230                 235                 240 


Met Asp Pro Gly Ser Arg Arg Thr Phe Asp Leu Ser Tyr Tyr Arg Leu 
                245                 250                 255     


Leu Leu Lys Arg Arg Gly Leu Phe Glu Ser Asp Ser Ala Leu Thr Lys 
            260                 265                 270         


Ser Ser Gln Thr Leu Arg Tyr Val Asn Lys Ile Leu Gln Gly Ser Leu 
        275                 280                 285             


Asp Asn Phe Tyr Lys Glu Phe Gly Leu Ala Met Glu Lys Met Gly Arg 
    290                 295                 300                 


Ile Asp Val Lys Thr Gly Ser Ser Gly Glu Ile Arg Arg Asn Cys Ala 
305                 310                 315                 320 


Phe Val Asn Ser 
                


<210>  49
<211>  317
<212>  PRT
<213>  Artemisia annua

<400>  49

Met Gly Tyr Pro Lys Ser Ile Gly Thr Ile Leu Val Pro Ile Val Val 
1               5                   10                  15      


Leu Leu Val Ser Met Asn Tyr Met Pro Cys Lys Ala Gln Leu Ser Thr 
            20                  25                  30          


Thr Phe Tyr Asp Asn Thr Cys Pro Thr Ala Leu Thr Thr Ile Arg Asp 
        35                  40                  45              


Ser Ile Ser Ser Ala Val Ser Arg Asn Thr Arg Met Ala Ala Leu Ile 
    50                  55                  60                  


Ile Arg Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Glu Gly Gly Glu Lys Ala Ala Pro Ala Asn Asn Gly Val 
                85                  90                  95      


Leu Gly Tyr Asp Ala Ile Asp Asp Ala Lys Ala Ala Val Glu Ser Val 
            100                 105                 110         


Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Val Ala Ala Arg 
        115                 120                 125             


Asp Ala Ser Val Ala Val Gly Gly Pro Ser Trp Ala Val Arg Leu Gly 
    130                 135                 140                 


Arg Arg Asp Ser Pro Asp Ser Asn Pro Gly Gln Ala Ala Thr Asp Leu 
145                 150                 155                 160 


Pro Arg Gly Asn Asn Asn Leu Ala Gln Leu Ile Ala Ser Phe Asp Arg 
                165                 170                 175     


Lys Gly Leu Ser Val Arg Asp Met Val Ala Leu Ser Gly Ser His Thr 
            180                 185                 190         


Ile Gly Gln Ala Arg Cys Val Thr Tyr Arg Ala Arg Ile Tyr Asp Asn 
        195                 200                 205             


Thr Ser Asn Ile Asp Ala Thr Phe Ala Ala Asn Leu Arg Ser Asp Cys 
    210                 215                 220                 


Pro Gln Thr Gly Thr Thr Thr Thr Ser Ala Pro Leu Asp Leu Gln Thr 
225                 230                 235                 240 


Pro Asn Thr Phe Asp Asn Asn Tyr Phe Arg Asn Leu Gln Ala Ser Arg 
                245                 250                 255     


Gly Leu Leu Thr Ser Asp Gln Val Leu Phe Asn Gly Asp Ser Thr Asp 
            260                 265                 270         


Ser Ile Val Thr Glu Tyr Val Asp Asn Pro Ser Leu Phe Asp Ser Asp 
        275                 280                 285             


Phe Ala Thr Ala Met Ile Asn Met Gly Asp Ile Asp Pro Leu Thr Gly 
    290                 295                 300                 


Thr Ile Gly Thr Ile Arg Thr Leu Cys Asn Thr Ala Asn 
305                 310                 315         


<210>  50
<211>  321
<212>  PRT
<213>  Artemisia annua

<400>  50

Met Gly Tyr Pro Lys Ser Ile Gly Thr Ile Leu Val Pro Ile Val Val 
1               5                   10                  15      


Leu Leu Val Ser Ile Asn Tyr Met Pro Cys Lys Ala Gln Leu Ser Thr 
            20                  25                  30          


Thr Phe Tyr Asp Asn Thr Cys Pro Thr Ala Leu Thr Thr Ile Arg Asp 
        35                  40                  45              


Ser Val Arg Ser Ala Val Ser Ser Asn Arg Arg Met Ala Ala Leu Leu 
    50                  55                  60                  


Ile Arg Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Asp Gly Thr Gly Ser Glu Arg Arg Ser Leu Ala Asn Asp 
                85                  90                  95      


Gly Val Gly Gly Tyr Glu Ala Ile Asp Asp Ala Lys Ala Ala Val Glu 
            100                 105                 110         


Ser Val Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Val Ala 
        115                 120                 125             


Ala Arg Asp Ala Ser Val Ala Val Asn Gly Pro Ser Trp Ala Val Arg 
    130                 135                 140                 


Leu Gly Arg Arg Asp Ser Ser Asp Ser Asn Ala Ala Glu Ala Gly Thr 
145                 150                 155                 160 


Asp Leu Pro Arg Gly Asn Asn Asn Leu Asn Glu Leu Ile Ala Ser Phe 
                165                 170                 175     


Ala Arg Lys Gly Leu Ser Val Arg Asp Met Val Ala Leu Ser Gly Ser 
            180                 185                 190         


His Thr Ile Gly Gln Ala Arg Cys Val Thr Phe Arg Ala Arg Ile Tyr 
        195                 200                 205             


Asp Asn Asn Ser Asn Ile Asp Pro Thr Phe Arg Asp Asn Leu Arg Arg 
    210                 215                 220                 


Asn Cys Pro Gln Ala Ala Pro Asn Gly Asn Asn Asn Ser Glu Pro Leu 
225                 230                 235                 240 


Asp Leu Gln Thr Pro Asn Thr Phe Asp Asn Asn Tyr Phe Leu Asn Leu 
                245                 250                 255     


Arg Val Ser Arg Gly Leu Leu Thr Ser Asp Gln Glu Leu Phe Asn Gly 
            260                 265                 270         


Gly Ser Thr Asp Ser Ile Val Thr Glu Tyr Val Asp Asn Pro Ser Leu 
        275                 280                 285             


Phe Asp Ser Asp Phe Ala Thr Ala Met Val Asn Met Gly Asp Ile Asp 
    290                 295                 300                 


Pro Leu Thr Gly Thr Ser Gly Thr Ile Arg Thr Leu Cys Ser Thr Ala 
305                 310                 315                 320 


Asn 
    


<210>  51
<211>  316
<212>  PRT
<213>  Artemisia annua

<400>  51

Met Ser Lys Ile Thr Ile Ser Ala Val Val Ala Phe Leu Leu Ile Leu 
1               5                   10                  15      


Ala Val Val Pro Phe Ser Arg Ala Ala Leu Asn Ala His Tyr Tyr Asp 
            20                  25                  30          


Gln Thr Cys Pro Gln Ala Glu Ser Ile Ile Phe Gln Thr Ile Arg Asn 
        35                  40                  45              


Ala Ser Ile Tyr Asp Pro Lys Val Pro Ala Arg Leu Leu Arg Met Phe 
    50                  55                  60                  


Phe His Asp Cys Phe Ile Arg Gly Cys Asp Ala Ser Leu Leu Leu Asp 
65                  70                  75                  80  


Ser Thr Pro Gly Asn Lys Ala Glu Lys Asp Gly Pro Pro Asn Val Ser 
                85                  90                  95      


Val Arg Ser Phe Tyr Val Ile Asp Asp Ala Lys Thr Lys Leu Glu Lys 
            100                 105                 110         


Ala Cys Pro Arg Thr Val Ser Cys Ser Asp Val Leu Ala Ile Ala Ala 
        115                 120                 125             


Arg Asp Val Val Ala Met Ser Arg Gly Pro Trp Trp His Val Leu Lys 
    130                 135                 140                 


Gly Arg Lys Asp Gly Arg Val Ser Lys Ala Asn Glu Thr Ile Asn Leu 
145                 150                 155                 160 


Pro Ser Pro Phe Ser Asn Thr Thr Thr Leu Ile Gln Ser Phe Ala Lys 
                165                 170                 175     


Arg Gly Leu Asn Val Lys Asp Leu Val Thr Leu Ser Gly Gly His Thr 
            180                 185                 190         


Leu Gly Phe Ser His Cys Ser Ser Phe Ser Ala Arg Leu Gln Asn Ser 
        195                 200                 205             


Thr Asp Thr Ser Ile Asn Ser Glu Phe Ala Met Ser Leu Arg Lys Lys 
    210                 215                 220                 


Cys Pro Leu His Asn Lys Asp Arg Asn Ala Gly Glu Phe Leu Asp Ser 
225                 230                 235                 240 


Thr Ser Ala Lys Phe Asp Asn Asp Tyr Tyr Lys Arg Ile Thr Met Gly 
                245                 250                 255     


Lys Gly Val Phe Gly Ser Asp Gln Ala Leu Tyr Gly Asp Asp Arg Thr 
            260                 265                 270         


Lys Ser Ile Val Asp Ser Tyr Ala Lys Asp Glu Lys Arg Phe Phe Thr 
        275                 280                 285             


Glu Phe Ala Ala Ser Met Val Lys Leu Gly Asn Val Gly Val Ile Glu 
    290                 295                 300                 


Asp Gly Glu Ile Arg Val Lys Cys Ser Ile Val Asn 
305                 310                 315     


<210>  52
<211>  316
<212>  PRT
<213>  Artemisia annua

<400>  52

Met Ser Lys Ile Thr Ile Ser Ala Val Val Ala Phe Leu Leu Ile Leu 
1               5                   10                  15      


Ala Val Val Pro Phe Ser Arg Ala Ala Leu Asn Ala His Tyr Tyr Asp 
            20                  25                  30          


Gln Thr Cys Pro Gln Ala Glu Ser Ile Ile Phe Gln Thr Ile Arg Asn 
        35                  40                  45              


Ala Ser Ile Tyr Asp Pro Lys Val Pro Ala Arg Leu Leu Arg Met Phe 
    50                  55                  60                  


Phe His Asp Cys Phe Ile Arg Gly Cys Asp Ala Ser Leu Leu Leu Asp 
65                  70                  75                  80  


Ser Thr Pro Gly Asn Lys Ala Glu Lys Asp Gly Pro Pro Asn Val Ser 
                85                  90                  95      


Val Arg Ser Phe Tyr Val Ile Asp Asp Ala Lys Thr Lys Leu Glu Lys 
            100                 105                 110         


Ala Cys Pro Arg Thr Val Ser Cys Ser Asp Val Leu Ala Ile Ala Ala 
        115                 120                 125             


Arg Asp Val Val Ala Met Ser Arg Gly Pro Trp Trp His Val Leu Lys 
    130                 135                 140                 


Gly Arg Lys Asp Gly Arg Val Ser Lys Ala Asn Glu Thr Ile Asn Leu 
145                 150                 155                 160 


Pro Ser Pro Phe Ser Asn Thr Thr Thr Leu Ile Gln Ser Phe Ala Lys 
                165                 170                 175     


Arg Gly Leu Asn Val Lys Asp Leu Val Thr Leu Ser Gly Gly His Thr 
            180                 185                 190         


Leu Gly Phe Ser His Cys Ser Ser Phe Ser Ala Arg Leu Gln Asn Ser 
        195                 200                 205             


Thr Asp Thr Ser Ile Asn Ser Glu Phe Ala Met Ser Leu Arg Lys Lys 
    210                 215                 220                 


Cys Pro Leu Gln Asn Lys Asp Arg Asn Ala Gly Glu Phe Leu Asp Ser 
225                 230                 235                 240 


Thr Ser Ala Lys Phe Asp Asn Asp Tyr Tyr Lys Arg Ile Thr Met Gly 
                245                 250                 255     


Lys Gly Val Phe Gly Ser Asp Gln Ala Leu Tyr Gly Asp Asp Arg Thr 
            260                 265                 270         


Lys Ser Ile Val Asp Ser Tyr Ala Lys Asp Glu Lys Leu Phe Phe Thr 
        275                 280                 285             


Glu Phe Ala Ala Ser Met Val Lys Leu Gly Asn Val Gly Val Ile Glu 
    290                 295                 300                 


Asp Gly Glu Ile Arg Val Lys Cys Ser Ile Val Asn 
305                 310                 315     


<210>  53
<211>  321
<212>  PRT
<213>  Artemisia annua

<400>  53

Met Gly Tyr His Lys Ser Leu Arg Met Ile Leu Val Pro Ile Val Val 
1               5                   10                  15      


Leu Leu Val Ser Val Asn Tyr Met Pro Cys Lys Ala Gln Leu Cys Pro 
            20                  25                  30          


Lys Phe Tyr Asp Asp Thr Cys Pro Ser Ala Leu Ala Thr Ile Arg Asp 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ser Ser Asn Arg Arg Met Ala Ala Phe Leu 
    50                  55                  60                  


Ile Arg Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Glu Gly Thr Gly Ser Glu Lys Glu Ser Pro Met Asn Asp 
                85                  90                  95      


Gly Val Leu Gly Tyr Glu Ala Ile Asp Asp Ile Lys Ala Ala Val Glu 
            100                 105                 110         


Ser Val Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Val Ala 
        115                 120                 125             


Ala Arg Asp Ala Ser Val Glu Val Gly Gly Pro Ser Trp Glu Val Arg 
    130                 135                 140                 


Leu Gly Arg Arg Asp Ser Ile Gly Thr Asn Ala Ser Gln Ala Ile Thr 
145                 150                 155                 160 


Asp Ile Pro Arg Gly His Asn Asn Leu Ser Glu Leu Ile Ala Ser Phe 
                165                 170                 175     


Asp Arg Lys Gly Leu Ser Val Arg Asp Met Val Ala Leu Ser Gly Ser 
            180                 185                 190         


His Thr Ile Gly Met Ala Arg Cys Val Arg Phe Arg Asp Arg Ile Tyr 
        195                 200                 205             


Asp Asn Thr Ser Asn Ile Asp Ala Ser Phe Ala Ala Asn Leu Arg Ser 
    210                 215                 220                 


Asn Cys Pro Gln Thr Ala Pro Asn Gly Asp Gly Asn Leu Glu Pro Leu 
225                 230                 235                 240 


Asp Leu Gln Thr Pro Asn Thr Phe Asp Asn Asn Tyr Phe Arg Asn Leu 
                245                 250                 255     


Val Thr Arg Arg Gly Leu Leu Thr Ser Asp Gln Val Leu Phe Asn Gly 
            260                 265                 270         


Asp Ser Thr Asp Ser Ile Val Thr Glu Tyr Val Asp Asn Pro Ser Leu 
        275                 280                 285             


Phe Asp Ser Asp Phe Ala Thr Ala Met Val Lys Met Gly Asp Ile Glu 
    290                 295                 300                 


Pro Leu Thr Gly Thr Ser Gly Thr Ile Arg Thr Arg Cys Asn Thr Ala 
305                 310                 315                 320 


Asn 
    


<210>  54
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  54

Met Lys Gly Val Cys Leu Ile Phe Gly Val Leu Val Ile Leu Gly Ser 
1               5                   10                  15      


Val Arg Cys Glu Leu Thr Thr Gly Phe Tyr Ser His Ser Cys Pro Lys 
            20                  25                  30          


Ala Glu Lys Ile Ile Gln Asp Tyr Val Asn Gln His Ile Leu Lys Val 
        35                  40                  45              


Pro Ser Leu Ala Ala Ala Leu Ile Arg Met His Phe His Asp Cys Phe 
    50                  55                  60                  


Val Arg Gly Cys Asp Ala Ser Leu Leu Leu Asn Val Thr Pro Thr Ser 
65                  70                  75                  80  


Gly Asn Gln Thr Glu Lys Gly Ala Ile Pro Asn Gln Thr Ile Leu Gly 
                85                  90                  95      


Phe Asp Phe Ile Asp Lys Leu Lys Ser Leu Val Glu Ala Glu Cys Pro 
            100                 105                 110         


Gly Val Val Ser Cys Ala Asp Ile Ile Thr Leu Ala Ala Arg Asp Ser 
        115                 120                 125             


Ile Val Val Ile Gly Gly Pro Ser Trp Lys Val Pro Thr Gly Arg Arg 
    130                 135                 140                 


Asp Gly Leu Ile Ser Ile Ala Phe Asp Thr Phe Thr Gln Ile Pro Ala 
145                 150                 155                 160 


Pro Phe Asp Asn Ile Thr Ile Leu Gln Gln Lys Leu Val Asn Lys Gly 
                165                 170                 175     


Leu Asp Leu Lys Asp Leu Val Val Leu Ser Gly Val His Thr Ile Gly 
            180                 185                 190         


Val Ala His Cys Ser Ser Phe Ser Asn Arg Leu Tyr Asn Phe Ser Gly 
        195                 200                 205             


Arg Gly Asp Gln Asp Pro Thr Leu Asp Gly Glu Tyr Ala Asn Asn Leu 
    210                 215                 220                 


Arg Ser Arg Lys Cys Thr Thr Pro Asn Asp Ser Thr Thr Leu Val Glu 
225                 230                 235                 240 


Met Asp Pro Gly Ser Ser Lys Thr Phe Asp Arg Ser Tyr Tyr Thr Leu 
                245                 250                 255     


Leu Leu Lys Arg Arg Gly Leu Phe Gln Ser Asp Ser Ala Leu Thr Lys 
            260                 265                 270         


Asn Ala Thr Thr Leu Lys Tyr Ile Asn Lys Ile Leu Lys Gly Ser Leu 
        275                 280                 285             


Lys Lys Phe Tyr Lys Gln Phe Ala Leu Ser Met Gln Lys Met Gly Arg 
    290                 295                 300                 


Ile Asp Val Lys Thr Gly Ser Ala Gly Glu Ile Arg Arg Asn Cys Ala 
305                 310                 315                 320 


Phe Val Asn Ser 
                


<210>  55
<211>  322
<212>  PRT
<213>  Artemisia annua

<400>  55

Met Asp Ser Lys Lys Ser Ile Leu Phe Val Val Leu Leu Ala Thr Leu 
1               5                   10                  15      


Ile Thr Leu Ala Leu Gly Gln Thr Arg Val Gly Phe Tyr Gln Thr Ser 
            20                  25                  30          


Cys Pro Arg Val Glu Thr Ile Val Gln Thr Ala Val Arg Ser Ala Ile 
        35                  40                  45              


Asn Ser Asn Pro Ala Ile Ala Pro Gly Leu Leu Arg Met His Phe His 
    50                  55                  60                  


Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu Ile Asp Gly Ala 
65                  70                  75                  80  


Ser Ser Glu Lys Thr Ala Pro Pro Asn Gly Phe Leu Arg Gly Phe Glu 
                85                  90                  95      


Val Ile Asp Ala Ala Lys Thr Gln Leu Glu Thr Ala Cys Pro Gly Val 
            100                 105                 110         


Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val 
        115                 120                 125             


Gln Thr Gly Gly Ala Ser Trp Gln Val Pro Leu Gly Arg Arg Asp Gly 
    130                 135                 140                 


Leu Val Ser Arg Ala Ser Asp Thr Gly Ser Leu Pro Gly Phe Asn Glu 
145                 150                 155                 160 


Pro Leu Asn Ala Leu Ile Arg Lys Phe Ala Asp Lys Asn Leu Asn Thr 
                165                 170                 175     


Gln Asp Leu Val Thr Leu Ser Gly Ala His Thr Ile Gly Thr Ala Ser 
            180                 185                 190         


Cys Leu Thr Phe Ser Tyr Arg Leu Tyr Asn Tyr Asn Asn Thr Asn Gly 
        195                 200                 205             


Pro Asp Pro Ser Ile Asp Pro Ser Phe Leu Pro Thr Leu Arg Asn Leu 
    210                 215                 220                 


Cys Pro Asn Gly Gly Asp Gly Thr Arg Arg Val Thr Leu Asp Thr Ser 
225                 230                 235                 240 


Ser Val Gly Asn Phe Asp Asn Ser Tyr Tyr Arg Asn Leu Arg Asn Arg 
                245                 250                 255     


Arg Gly Val Leu Glu Ser Asp Ala Ala Leu Trp Asn Asn Pro Ala Thr 
            260                 265                 270         


Gln Thr Leu Val Asn Arg Phe Leu Gly Ile Arg Gly Leu Ala Gly Leu 
        275                 280                 285             


Thr Phe Asn Val Glu Phe Gly Arg Ser Met Val Lys Met Gly Asn Ile 
    290                 295                 300                 


Glu Leu Lys Thr Gly Ser Gln Gly Glu Ile Arg Arg Val Cys Thr Ala 
305                 310                 315                 320 


Ile Asn 
        


<210>  56
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  56

Met Gln Arg Leu Thr Ser Val Val Phe Trp Phe Leu Val Phe Gly Pro 
1               5                   10                  15      


Phe Val Tyr Gly Gln Leu Asp Tyr Lys Phe Tyr Asp Ser Thr Cys Pro 
            20                  25                  30          


Asn Leu Thr Lys Ile Val Arg Phe Gly Ile Trp Ser Ala Met Ala Asn 
        35                  40                  45              


Asp Thr Arg Ile Ala Ala Ser Leu Leu Arg Leu His Phe His Asp Cys 
    50                  55                  60                  


Ile Ser Asn Gly Cys Glu Gly Ser Val Leu Leu Asp Lys Thr Ser Asp 
65                  70                  75                  80  


Phe Ser Ser Glu Lys Asp Ala Asn Pro Asn Arg Asn Ser Ala Arg Gly 
                85                  90                  95      


Phe Glu Leu Ile Asp Thr Ile Lys Ala Asn Val Glu Lys Ala Cys Pro 
            100                 105                 110         


Lys Thr Val Ser Cys Thr Asp Ile Leu Thr Leu Ala Ala Arg Glu Ala 
        115                 120                 125             


Val Phe Leu Ser Gly Gly Pro Phe Trp Ser Leu Ala Met Gly Arg Arg 
    130                 135                 140                 


Asp Gly Leu Thr Ala Asn Met Ser Ala Ala Asn Thr Asp Thr Pro Ser 
145                 150                 155                 160 


Pro Phe Glu Pro Leu Glu Asn Ile Thr Ala Lys Phe Thr Ser Lys Gly 
                165                 170                 175     


Leu Asn Leu Lys Asp Val Val Ala Leu Ser Gly Ala His Thr Ile Gly 
            180                 185                 190         


Phe Ala Gln Cys Phe Thr Phe Lys Ser Arg Leu Phe Asn Phe Asp Gly 
        195                 200                 205             


Ser Gly Ala Pro Asp Pro Gln Leu Asp Ser Ser Leu Ala Ser Ser Leu 
    210                 215                 220                 


Gln Thr Val Cys Pro Asn Gln Asp Asn Ser Asp Thr Asn Leu Val Pro 
225                 230                 235                 240 


Leu Asp Ser Val Thr Thr Ala Lys Phe Asp Asn Ile Tyr Tyr Lys Asn 
                245                 250                 255     


Ile Leu Asn Asn Ser Gly Ile Leu Gly Ser Asp Gln Ala Leu Met Asn 
            260                 265                 270         


Asp Asn Ile Thr Ala Thr Met Val Ile Asn Tyr Ser Lys Tyr Pro Tyr 
        275                 280                 285             


Leu Phe Ala Lys Asp Phe Gly Ala Ser Met Val Lys Leu Ser Thr Ile 
    290                 295                 300                 


Gly Ile Ile Thr Gly Gln Asn Gly Gln Val Arg Asn Arg Cys Asn Ile 
305                 310                 315                 320 


Val Asn Gln Asn 
                


<210>  57
<211>  234
<212>  PRT
<213>  Artemisia annua

<400>  57

Met Val Met Lys Ala Lys Ala Ala Val Asp Ala Val Ser Ser Cys Lys 
1               5                   10                  15      


Asn Lys Val Ser Cys Ala Asp Ile Leu Thr Met Ala Ala Arg Asp Val 
            20                  25                  30          


Val Gln Met Pro Glu Asn Ala Asn Cys Tyr Lys Asn Pro Val Asp Pro 
        35                  40                  45              


Thr Leu Ile Pro Ser Tyr Ala Ala Glu Leu Gln Gln Gln Cys Pro Lys 
    50                  55                  60                  


Asn Phe Asp Pro Asn Thr Val Ile Ala Leu Gly Pro Ser Thr Thr Gly 
65                  70                  75                  80  


Ile Phe Asp Asn Met Tyr Tyr Lys Asn Leu Gln Asn Gly Gln Gly Leu 
                85                  90                  95      


Leu Thr Ser Asp Gln Gly Cys Asp Ala Ser Ile Met Ile Gln Ser Ser 
            100                 105                 110         


Gly Ser Asn Thr Ala Glu Lys Asp His Gln Asp Asn Leu Ser Leu Ala 
        115                 120                 125             


Gly Asp Gly Phe Asp Met Val Asn Lys Ala Lys Ala Ala Ala Asp Ala 
    130                 135                 140                 


Val Pro Ser Cys Arg Asn Lys Val Ser Cys Ala Asp Ile Leu Thr Met 
145                 150                 155                 160 


Ala Thr Arg Asp Val Ile Lys Met Ala Gly Gly Pro Ser Tyr Pro Val 
                165                 170                 175     


Glu Leu Gly Arg Leu Asp Gly Leu Ser Ser Thr Ala Ala Ser Val Asn 
            180                 185                 190         


Gly Lys Leu Pro Ile Pro Asn Trp Asn Leu Asp Gln Leu Asn Asp Met 
        195                 200                 205             


Phe Ala Phe Asn Gly Leu Thr Gln Ile Asp Met Ile Ala Leu Ser Gly 
    210                 215                 220                 


Asn Asn Pro Ala Lys Gln Tyr Glu Leu Arg 
225                 230                 


<210>  58
<211>  327
<212>  PRT
<213>  Artemisia annua

<400>  58

Met Val Val Leu Ser His Asn Lys Lys Ser Ile Leu Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Ile Thr Leu Ser Leu Gly Gln Gly Thr Arg Leu Gly 
            20                  25                  30          


Phe Tyr Arg Thr Ser Cys Pro Arg Val Glu Ser Ile Val Gln Asn Ala 
        35                  40                  45              


Val Asn Ser Ala Val Arg Ala Asn Pro Thr Ile Ala Pro Gly Leu Leu 
    50                  55                  60                  


Arg Met Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile 
65                  70                  75                  80  


Leu Ile Asp Gly Ala Ser Ser Glu Lys Thr Ala Arg Pro Asn Ser Leu 
                85                  90                  95      


Leu Arg Gly Phe Glu Val Ile Asp Ala Ala Lys Arg Gln Leu Glu Ile 
            100                 105                 110         


Ala Cys Pro Arg Val Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala 
        115                 120                 125             


Arg Asp Ser Val Val Gln Thr Gly Gly Thr Gly Trp Ser Val Pro Leu 
    130                 135                 140                 


Gly Arg Arg Asp Gly Leu Val Ser Arg Ala Ala Asp Thr Ala Asn Leu 
145                 150                 155                 160 


Pro Ala Phe Asn Asp Pro Ile Asn Val Gln Ile Arg Lys Phe Thr Asp 
                165                 170                 175     


Lys Gly Leu Asn Thr Gln Asp Leu Val Ala Leu Ser Gly Ala His Thr 
            180                 185                 190         


Ile Gly Thr Ala Ala Cys Ala Leu Phe Ser Tyr Arg Leu Tyr Asn Tyr 
        195                 200                 205             


Asn Asn Thr Asn Gly Pro Asp Pro Thr Ile Asp Ala Ser Phe Leu Pro 
    210                 215                 220                 


Thr Leu Arg Asn Leu Cys Pro Asn Gly Gly Asp Gly Thr Thr Arg Val 
225                 230                 235                 240 


Thr Leu Asp Thr Gly Ser Val Arg Asn Phe Asp Asn Ser Tyr Tyr Ser 
                245                 250                 255     


Asn Leu Arg Asn Arg Arg Gly Val Leu Glu Ser Asp Ala Ala Leu Trp 
            260                 265                 270         


Asn Asn Pro Ala Thr Gln Thr Leu Val Asn Arg Phe Leu Gly Leu Arg 
        275                 280                 285             


Gly Leu Leu Gly Leu Arg Phe Asn Leu Glu Phe Gly Arg Ser Met Val 
    290                 295                 300                 


Lys Met Gly Asn Ile Glu Val Lys Thr Gly Thr Gln Gly Glu Ile Arg 
305                 310                 315                 320 


Arg Val Cys Thr Ala Thr Asn 
                325         


<210>  59
<211>  315
<212>  PRT
<213>  Artemisia annua

<400>  59

Met Gly Phe Leu Val Lys Phe Ala Phe Val Met Phe Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Ala Gln Leu Ser Thr Asn Phe Tyr Ser Lys Ser Cys Pro Asn 
            20                  25                  30          


Leu Phe Pro Ala Val Lys Ser Ala Val Gln Ala Ala Ile Ser Lys Glu 
        35                  40                  45              


Thr Arg Met Gly Ala Ser Leu Leu Arg Leu His Phe His Asp Cys Phe 
    50                  55                  60                  


Val Asn Gly Cys Asp Gly Ser Ile Leu Leu Asp Asp Thr Ser Ser Phe 
65                  70                  75                  80  


Thr Gly Glu Lys Asn Ala Ala Pro Asn Phe Gln Ser Ala Arg Gly Phe 
                85                  90                  95      


Asp Val Val Asp Asn Ile Lys Ser Ala Val Glu Lys Ala Cys Pro Gly 
            100                 105                 110         


Val Val Ser Cys Ala Asp Ile Leu Ala Ile Thr Ala Arg Asp Ser Val 
        115                 120                 125             


Gln Ile Leu Gly Gly Pro Thr Trp Asn Val Lys Leu Gly Arg Arg Asp 
    130                 135                 140                 


Ser Arg Thr Ala Ser Gln Ala Ala Ala Asn Ser Ser Ile Pro Pro Pro 
145                 150                 155                 160 


Thr Ser Ser Leu Ser Ala Leu Ile Ser Ser Phe Asn Arg Val Gly Leu 
                165                 170                 175     


Ser Ala Lys Asp Met Val Ala Leu Ser Gly Ser His Thr Ile Gly Gln 
            180                 185                 190         


Ala Arg Cys Thr Ser Phe Arg Pro Arg Ile Tyr Asn Glu Thr Asn Ile 
        195                 200                 205             


Asp Ala Ser Phe Ala Ala Ser Arg Arg Ser Asn Cys Pro Arg Thr Ser 
    210                 215                 220                 


Gly Ser Gly Asp Asn Asn Leu Ala Pro Leu Asp Leu Gln Thr Pro Thr 
225                 230                 235                 240 


Lys Phe Asn Asn Asp Tyr Tyr Lys Asn Leu Ile Ala Gln Lys Gly Leu 
                245                 250                 255     


Leu His Ser Asp Gln Gln Leu Phe Asn Gly Gly Ser Ala Asp Ser Thr 
            260                 265                 270         


Val Arg Gln Tyr Ser Ser Asn Pro Ser Gln Phe Ser Ser Asp Phe Ala 
        275                 280                 285             


Ala Ala Met Ile Lys Met Gly Asp Phe Arg Pro Leu Thr Gly Ser Ser 
    290                 295                 300                 


Gly Glu Ile Arg Lys Asn Cys Arg Lys Pro Asn 
305                 310                 315 


<210>  60
<211>  327
<212>  PRT
<213>  Artemisia annua

<400>  60

Met Val Val Leu Phe Asn Asn Lys Lys Pro Ile Leu Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Ile Thr Leu Ser Leu Gly Gln Gly Thr Arg Leu Gly 
            20                  25                  30          


Phe Tyr Arg Thr Ser Cys Pro Arg Val Glu Ser Ile Val Gln Asn Ala 
        35                  40                  45              


Val Asn Ser Ala Val Arg Ala Asn Pro Thr Ile Ala Pro Gly Leu Leu 
    50                  55                  60                  


Arg Met Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile 
65                  70                  75                  80  


Leu Ile Asp Gly Ala Ser Ser Glu Lys Thr Ala Arg Pro Asn Ser Leu 
                85                  90                  95      


Leu Arg Gly Phe Glu Val Ile Asp Ala Ala Lys Arg Gln Leu Glu Ile 
            100                 105                 110         


Ala Cys Pro Arg Val Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala 
        115                 120                 125             


Arg Asp Ser Val Val Gln Thr Gly Gly Thr Gly Trp Ser Val Pro Leu 
    130                 135                 140                 


Gly Arg Arg Asp Gly Leu Val Ser Arg Ala Ala Asp Thr Ala Asn Leu 
145                 150                 155                 160 


Pro Ala Phe Asn Asp Pro Ile Asn Val Gln Ile Arg Lys Phe Thr Asp 
                165                 170                 175     


Lys Gly Leu Asn Thr Gln Asp Leu Val Ala Leu Ser Gly Ala His Thr 
            180                 185                 190         


Ile Gly Thr Ala Ala Cys Ala Leu Phe Ser Tyr Arg Leu Tyr Asn Tyr 
        195                 200                 205             


Asn Asn Thr Asn Gly Pro Asp Pro Thr Ile Asp Ala Ser Phe Leu Pro 
    210                 215                 220                 


Thr Leu Arg Asn Leu Cys Pro Asn Gly Gly Asp Gly Thr Thr Arg Val 
225                 230                 235                 240 


Thr Leu Asp Thr Gly Ser Val Arg Asn Phe Asp Asn Ser Tyr Tyr Ser 
                245                 250                 255     


Asn Leu Arg Asn Arg Arg Gly Val Leu Glu Ser Asp Ala Ala Leu Trp 
            260                 265                 270         


Asn Asn Pro Ala Thr Gln Thr Leu Val Asn Arg Phe Leu Gly Leu Arg 
        275                 280                 285             


Gly Leu Leu Gly Leu Arg Phe Asn Ile Glu Phe Gly Arg Ser Met Val 
    290                 295                 300                 


Lys Met Gly Asn Ile Glu Val Lys Thr Gly Thr Gln Gly Glu Ile Arg 
305                 310                 315                 320 


Arg Val Cys Thr Ala Thr Asn 
                325         


<210>  61
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  61

Met Ala Ile Asn Leu Leu Ile Ile Ile Ser Leu Ser Leu Thr Leu Ile 
1               5                   10                  15      


Pro Val Ala Lys Ser Gln Ala Gly Leu Lys Ser Gly Phe Tyr Ser Ser 
            20                  25                  30          


Thr Cys Pro Lys Ala Glu Ala Thr Val Arg Ser Ile Val Glu Thr His 
        35                  40                  45              


Phe Lys Asp Asp Pro Thr Val Ala Ala Ala Leu Leu Arg Leu His Phe 
    50                  55                  60                  


His Asp Cys Phe Val Glu Gly Cys Asp Gly Ser Ile Leu Ile Lys Gly 
65                  70                  75                  80  


Lys Ser Ala Glu Ile Asn Ala Leu Ala Asn Leu Gly Leu Arg Gly Phe 
                85                  90                  95      


Glu Val Ile Asp Asp Ala Lys Thr Gln Leu Glu Thr Leu Cys Pro Gly 
            100                 105                 110         


Val Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val 
        115                 120                 125             


Asp Leu Ser Asp Gly Pro Asn Trp Ala Val Pro Thr Gly Arg Arg Asp 
    130                 135                 140                 


Gly Arg Val Ser Leu Ala Ser Lys Ala Ser Asn Leu Pro Ser Pro Leu 
145                 150                 155                 160 


Asp Ser Val Asp Thr Gln Arg Lys Lys Phe Ala Asp Lys Gly Leu Asp 
                165                 170                 175     


Asp Arg Asp Leu Val Thr Leu Ala Gly Ala His Thr Ile Gly Gln Thr 
            180                 185                 190         


Asp Cys Arg Phe Phe Arg Tyr Arg Leu Tyr Asn Phe Thr Thr Thr Gly 
        195                 200                 205             


Asn Ser Asp Pro Ser Leu Ser Gln Ser Ala Leu Thr Gln Phe Gln Ala 
    210                 215                 220                 


Gln Cys Pro Lys Asn Ser Asp Gly Thr Glu Arg Val Ala Leu Asp Lys 
225                 230                 235                 240 


Asp Ser Gln Met Lys Phe Asp Val Asn Tyr Phe Lys Asn Val Arg Asp 
                245                 250                 255     


Gly Asn Gly Val Leu Glu Ser Asp Gln Arg Leu Trp Gly Asp Pro Thr 
            260                 265                 270         


Thr His Asp Ile Val Lys Asn Tyr Ala Gly Thr Ile Arg Gly Leu Leu 
        275                 280                 285             


Gly Leu Arg Phe Asp Phe Glu Phe Lys Lys Ser Met Val Lys Met Ser 
    290                 295                 300                 


Ser Ile Glu Val Lys Thr Gly Asp Gln Gly Glu Ile Arg Lys Ile Cys 
305                 310                 315                 320 


Ser Lys Phe Asn 
                


<210>  62
<211>  327
<212>  PRT
<213>  Artemisia annua

<400>  62

Met Val Val Leu Phe Asn Asn Lys Lys Pro Ile Leu Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Ile Thr Leu Ser Leu Gly Gln Gly Thr Arg Leu Gly 
            20                  25                  30          


Phe Tyr Arg Thr Ser Cys Pro Arg Val Glu Ser Ile Val Gln Asn Ala 
        35                  40                  45              


Val Asn Ser Ala Val Arg Ala Asn Pro Thr Ile Ala Pro Gly Leu Leu 
    50                  55                  60                  


Arg Met Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile 
65                  70                  75                  80  


Leu Ile Asp Gly Ala Ser Ser Glu Lys Thr Ala Arg Pro Asn Ser Leu 
                85                  90                  95      


Leu Arg Gly Phe Glu Val Ile Asp Ala Ala Lys Arg Gln Leu Glu Ile 
            100                 105                 110         


Ala Cys Pro Arg Val Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala 
        115                 120                 125             


Arg Asp Ser Val Val Gln Thr Gly Gly Thr Gly Trp Ser Val Pro Leu 
    130                 135                 140                 


Gly Arg Lys Asp Gly Leu Val Ser Arg Ala Ala Asp Thr Ala Asn Leu 
145                 150                 155                 160 


Pro Ala Phe Asn Asp Pro Ile Asn Val Gln Ile Arg Lys Phe Thr Asp 
                165                 170                 175     


Lys Gly Leu Asn Thr Gln Asp Leu Val Ala Leu Ser Gly Ala His Thr 
            180                 185                 190         


Ile Gly Thr Ala Ala Cys Ala Leu Phe Ser Tyr Arg Leu Tyr Asn Tyr 
        195                 200                 205             


Asn Asn Thr Asn Gly Pro Asp Pro Thr Ile Asp Ala Ser Phe Leu Pro 
    210                 215                 220                 


Thr Leu Arg Asn Leu Cys Pro Asn Gly Gly Asp Gly Thr Thr Arg Val 
225                 230                 235                 240 


Thr Leu Asp Thr Gly Ser Val Arg Asn Phe Asp Asn Ser Tyr Tyr Ser 
                245                 250                 255     


Asn Leu Arg Asn Arg Arg Gly Val Leu Glu Ser Asp Ala Ala Leu Trp 
            260                 265                 270         


Asn Asn Pro Ala Thr Gln Thr Leu Val Asn Arg Phe Leu Gly Leu Arg 
        275                 280                 285             


Gly Leu Leu Gly Leu Arg Phe Asn Ile Glu Phe Gly Arg Ser Met Val 
    290                 295                 300                 


Lys Met Gly Asn Ile Glu Val Lys Thr Gly Thr Gln Gly Glu Ile Arg 
305                 310                 315                 320 


Arg Val Cys Thr Ala Thr Asn 
                325         


<210>  63
<211>  328
<212>  PRT
<213>  Artemisia annua

<400>  63

Met Lys Gly Phe Trp Ser Leu Gly Leu Met Val Val Gly Val Leu Ser 
1               5                   10                  15      


Ile Leu Gly Ser Val Gln Gly Asp Leu Glu Met Gly Phe Tyr Ser Ser 
            20                  25                  30          


Ser Cys Pro Lys Ala Glu Lys Ile Val Gln Asp Phe Val Asn Gln His 
        35                  40                  45              


Ile Pro Asn Ala Pro Ser Leu Ala Ala Thr Leu Ile Arg Met His Phe 
    50                  55                  60                  


His Asp Cys Phe Val Arg Gly Cys Asp Gly Ser Val Leu Leu Asn Phe 
65                  70                  75                  80  


Thr Ser Ser Ser Gly Asn Gln Thr Glu Lys Val Ala Val Pro Asn Arg 
                85                  90                  95      


Thr Leu Arg Gly Phe Gly Phe Ile Asp Ala Ile Lys Ser Leu Val Glu 
            100                 105                 110         


Ala Glu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Ile Ala Leu Ala 
        115                 120                 125             


Ala Arg Asp Ser Ile Val Leu Thr Gly Gly Pro Ser Trp Lys Val Pro 
    130                 135                 140                 


Thr Gly Arg Arg Asp Gly Leu Leu Ser Asn Ala Ser Glu Ala Leu Ala 
145                 150                 155                 160 


Gln Ile Pro Ala Pro Thr Asp Asn Ile Thr Ile Leu Ile Gln Lys Phe 
                165                 170                 175     


Ala Asn Lys Ser Leu Asp Leu Lys Asp Leu Val Leu Leu Ser Gly Ala 
            180                 185                 190         


His Thr Ile Gly Ile Ala His Cys Pro Ser Phe Ser Asn Arg Leu Tyr 
        195                 200                 205             


Asn Phe Thr Gly Val Gly Asp Arg Asp Pro Ser Leu Asp Ser Glu Tyr 
    210                 215                 220                 


Ala Asp Val Leu Arg Ser Thr Lys Cys Arg Thr Gln Asn Asp Asn Thr 
225                 230                 235                 240 


Thr Ile Val Glu Met Asp Pro Gly Ser Arg Lys Thr Phe Asp Leu Ser 
                245                 250                 255     


Tyr Tyr Thr Leu Leu Leu Lys Arg Arg Gly Leu Phe Glu Ser Asp Ser 
            260                 265                 270         


Ala Leu Thr Arg Asn Ser Asn Thr Leu Thr Tyr Ile Asn Gln Leu Leu 
        275                 280                 285             


Gln Gly Ser Leu Gln Asn Phe Phe Ser Glu Phe Ala Leu Ser Met Glu 
    290                 295                 300                 


Lys Met Asn Gln Ile Gly Val Lys Thr Gly Thr Thr Gly Glu Ile Arg 
305                 310                 315                 320 


Lys Asn Cys Ala Val Val Asn Ser 
                325             


<210>  64
<211>  519
<212>  PRT
<213>  Artemisia annua

<400>  64

Met Ser His Asn Leu Phe Leu Leu Pro Leu Val Phe Leu Ala Leu Phe 
1               5                   10                  15      


Pro Val Val Glu Pro Arg Leu Arg Gln Gln Tyr Tyr Ser Glu Thr Cys 
            20                  25                  30          


Pro Asn Ala Glu Thr Ile Val Thr Phe Met Met Gln Lys Ala Met Ile 
        35                  40                  45              


Lys Asp Pro Arg Ser Gly Ala Ser Val Met Arg Phe Gln Phe His Asp 
    50                  55                  60                  


Cys Phe Val Asn Gly Cys Asp Ala Ser Leu Leu Leu Asp Asp Thr Pro 
65                  70                  75                  80  


Thr Met Leu Gly Glu Lys Leu Ser Leu Ser Asn Ile Asp Ser Leu Arg 
                85                  90                  95      


Ser Tyr Asp Val Val Asp Trp Ile Lys Gly Ala Leu Glu Arg Thr Cys 
            100                 105                 110         


Pro Met Thr Val Ser Cys Ala Asp Ile Ile Ile Met Ala Ser Arg Asp 
        115                 120                 125             


Ala Val Thr Leu Ser Gly Gly Pro His Trp Gly Val Lys Leu Gly Arg 
    130                 135                 140                 


Leu Asp Ser Leu Ser Ala Ser Gln Lys Asp Ser Asp Asp Ile Met Pro 
145                 150                 155                 160 


Ser Pro Arg Ala Asn Ala Ser Met Leu Ile Asp Leu Phe Ala Arg Phe 
                165                 170                 175     


Ser Leu Ser Val Gln Asp Leu Val Ala Leu Ser Gly Ser His Ser Ile 
            180                 185                 190         


Gly Asn Ala Arg Cys Phe Ser Ile Val His Arg Ile Tyr Asn Gln Ser 
        195                 200                 205             


Asp Asp Gly Lys Pro Asp Pro Ser Ile Glu Leu Gly Phe Leu Lys Lys 
    210                 215                 220                 


Leu Gln Glu Leu Cys Pro Leu Gly Gly Asp Glu Asn Val Ile Gly Asp 
225                 230                 235                 240 


Leu Asp Phe Thr Pro Lys Thr Phe Asp Asn Glu Tyr Phe Lys Asp Leu 
                245                 250                 255     


Val Asn Gly Lys Gly Phe Leu Asn Ser Asp Glu Thr Leu Phe Thr Asn 
            260                 265                 270         


Pro Gln Thr Arg Glu Tyr Val Gln Arg Tyr Ser Glu Asp Gln Ser Ala 
        275                 280                 285             


Phe Phe Lys Asp Phe Val Gln Gly Met Ile Lys Leu Gly Asp Leu Gln 
    290                 295                 300                 


Ser Gly Arg Pro Gly Glu Ile Arg Lys Asn Cys Arg Val Val Asn Asn 
305                 310                 315                 320 


Pro Pro Pro Val Asn Leu Met Ser Gly Gly Pro Asp Trp Glu Val Lys 
                325                 330                 335     


Leu Gly Arg Asn Asp Ser Leu Thr Ala Ser Gln Lys Asp Ser His Asp 
            340                 345                 350         


Ile Met Pro Ser Pro Ser Ala Asn Ala Ser Thr Leu Ile Asp Leu Phe 
        355                 360                 365             


Ala Lys Phe Asp Leu Ser Ile Lys Asp Leu Val Ala Leu Ser Gly Ser 
    370                 375                 380                 


His Ser Ile Gly Asn Gly Arg Cys Phe Ser Ile Val His Arg Leu Tyr 
385                 390                 395                 400 


Asn Gln Thr Asp Asp Gly Arg Pro Asn Pro Ser Ile Glu Pro Arg Tyr 
                405                 410                 415     


Arg Gln Lys Leu Asp Lys Leu Cys Pro Leu Gly Gly Asp Glu Glu Val 
            420                 425                 430         


Ile Gly Asp Leu Asp Phe Thr Pro Arg Val Phe Asp Asn Gln Tyr Phe 
        435                 440                 445             


Lys Asp Leu Val Asn Glu Arg Gly Phe Leu Asn Ser Asp Glu Thr Leu 
    450                 455                 460                 


Tyr Thr Phe Trp Gln Thr Arg Gly Tyr Val Gln Arg Tyr Ser Glu Asn 
465                 470                 475                 480 


Gln Ser Thr Phe Phe Lys Asp Phe Val Lys Gly Met Ile Lys Met Gly 
                485                 490                 495     


Asp Leu Gln Ser Gly Gln Gly Lys Phe Ile Gly Ile Val Glu Trp Leu 
            500                 505                 510         


Met Met Arg His Arg Trp Lys 
        515                 


<210>  65
<211>  321
<212>  PRT
<213>  Artemisia annua

<400>  65

Met Gly Tyr Asp Lys Ser Ile Gly Thr Ile Leu Val Pro Ile Val Val 
1               5                   10                  15      


Leu Leu Val Ser Val Asn Tyr Met Pro Cys Lys Ala Gln Leu Cys Thr 
            20                  25                  30          


Thr Phe Tyr Asp Asp Thr Cys Pro Ser Ala Leu Ala Thr Ile Arg Asp 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ser Ser Asn Arg Arg Met Ala Ala Leu Leu 
    50                  55                  60                  


Ile Arg Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Glu Gly Thr Gly Ser Glu Lys Ala Ser Pro Ala Asn Asp 
                85                  90                  95      


Gly Val Leu Gly Tyr Glu Thr Val Asp Asp Ile Lys Ala Ala Val Glu 
            100                 105                 110         


Ser Val Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Val Ala 
        115                 120                 125             


Ala Arg Asp Ala Ser Val Glu Val Gly Gly Pro Ser Trp Glu Val Lys 
    130                 135                 140                 


Leu Gly Arg Arg Asp Ser Thr Gly Ser Asn Ala Ser Gln Ala Val Thr 
145                 150                 155                 160 


Asp Leu Pro Arg Gly Asn Asn Asn Leu Thr Glu Leu Ile Ala Ser Phe 
                165                 170                 175     


Asp Arg Lys Gly Leu Ser Val Arg Asp Met Val Ala Leu Ser Gly Ser 
            180                 185                 190         


His Thr Ile Gly Lys Ala Arg Cys Val Arg Phe Arg Asp Arg Ile Tyr 
        195                 200                 205             


Ala Asn Asn Ser Asn Ile Asp Ala Thr Phe Ala Ala Asn Leu Arg Arg 
    210                 215                 220                 


Asn Cys Pro Gln Thr Ala Pro Asn Gly Asp Gly Asn Leu Glu Pro Leu 
225                 230                 235                 240 


Asp Leu Gln Thr Pro Asn Lys Phe Asp Asn Asn Tyr Phe Arg Asn Leu 
                245                 250                 255     


Val Ala Ser Lys Gly Leu Leu Thr Ser Asp Gln Val Leu Phe Asn Gly 
            260                 265                 270         


Asp Ser Thr Asp Ser Ile Val Thr Glu Tyr Val Asp Asn Pro Ser Leu 
        275                 280                 285             


Phe Asp Cys Asp Phe Ala Lys Ala Met Val Asn Met Gly Asp Ile Glu 
    290                 295                 300                 


Pro Leu Thr Gly Thr Ser Gly Ile Ile Arg Thr Leu Cys Ser Thr Ala 
305                 310                 315                 320 


Asn 
    


<210>  66
<211>  326
<212>  PRT
<213>  Artemisia annua

<400>  66

Met Ile Gln Lys Asn Phe Gly Phe Phe Leu Ala Ser Ile Leu Val Val 
1               5                   10                  15      


Gly Cys Met Gly Gly Gly Gly Leu Lys Met Lys Tyr Tyr Lys Lys Arg 
            20                  25                  30          


Cys Asp Pro Ile Ser Val Glu Asp Thr Val Arg Glu Ile Val Trp Ser 
        35                  40                  45              


Lys Val Asp Lys Thr Pro Ser Leu Ala Ala Lys Leu Leu Arg Leu His 
    50                  55                  60                  


Tyr His Asp Cys Phe Val Arg Gly Cys Asp Gly Ser Ile Leu Leu Asp 
65                  70                  75                  80  


Ser Thr Gln Asn Val Thr Thr Glu Lys Thr Ala Gly Pro Asn Arg Ser 
                85                  90                  95      


Val Thr Gly Tyr Asp Ile Ile Asp Glu Ile Lys Thr Val Leu Glu Ala 
            100                 105                 110         


Ser Cys Pro Gly Ile Val Ser Cys Ala Asp Ile Val Ala Leu Ala Ala 
        115                 120                 125             


Arg Asp Ala Val Ser Phe Gln Phe Gln Thr Glu Met Trp Pro Val Phe 
    130                 135                 140                 


Thr Gly Arg Lys Asp Gly Ser Ile Ser Leu Ala Ser Glu Val Gly Thr 
145                 150                 155                 160 


Asn Leu Pro Ser Ala Asn Ala Asn Phe Thr Thr Leu Leu Ser Gln Phe 
                165                 170                 175     


Arg Thr Lys Gly Leu Asp Leu Lys Asp Leu Val Thr Leu Ser Gly Ala 
            180                 185                 190         


His Thr Ile Gly Asn Ser Arg Cys Ala Leu Val Ala Arg Arg Leu Tyr 
        195                 200                 205             


Asn Phe Thr Gly Ile Gly Asp Ala Asp Pro Ser Leu Asp Glu Thr Tyr 
    210                 215                 220                 


Ala Gln Thr Leu Arg Lys Leu Cys Pro Asn Pro Gln Asn Pro Ala Thr 
225                 230                 235                 240 


Ile Leu Glu Met Asp Pro Asn Ser Ser Leu Ser Phe Asp Ser Asn Tyr 
                245                 250                 255     


Tyr Gln Ala Leu Asn Gln His Lys Gly Leu Phe Val Ser Asp Ala Ala 
            260                 265                 270         


Leu Leu Thr Asn Leu Gln Ser Ala Leu Ile Ala Lys Val Phe Glu Asp 
        275                 280                 285             


Pro Thr Val Phe Phe Ala Glu Phe Ala Arg Ser Met Val Arg Met Gly 
    290                 295                 300                 


Ala Ile Glu Val Leu Thr Gly Gly Gln Gly Glu Val Arg Lys Asn Cys 
305                 310                 315                 320 


Arg Ala Ile Asn Asp Gln 
                325     


<210>  67
<211>  326
<212>  PRT
<213>  Artemisia annua

<400>  67

Met Ile Lys Met Arg Ile Met Met Leu Val Met Ile Ile Val Phe Lys 
1               5                   10                  15      


Phe Phe Ile Gly Phe Thr Glu Ala Gln Leu Glu Val Gly Phe Tyr Asn 
            20                  25                  30          


Lys Val Cys Pro Ala Ala Glu Thr Val Val Ala Asn Val Val Lys Asp 
        35                  40                  45              


Ala Thr Lys Ser Asp Ser Gln Thr Pro Ala Ala Met Leu Arg Leu His 
    50                  55                  60                  


Phe His Asp Cys Phe Val Glu Gly Cys Asp Gly Ser Ile Leu Ile Asp 
65                  70                  75                  80  


Asn Gly Asn Asn Ser Glu Arg Ile Ala Asn Gly His Gln Gly Val Arg 
                85                  90                  95      


Gly Tyr Asp Val Ile Glu Asn Ala Lys Ala Gln Leu Glu Ser Met Cys 
            100                 105                 110         


Pro Gly Val Val Ser Cys Ala Asp Ile Val Ala Met Ala Ala Arg Asp 
        115                 120                 125             


Ala Val Ala Leu Ser His Gly Pro Val Tyr Gln Val Glu Thr Gly Arg 
    130                 135                 140                 


Lys Asp Gly Leu Val Ser Arg Met Glu Leu Ala Gly Arg Met Pro Asp 
145                 150                 155                 160 


Val Gln Asp Ser Ile Gln Ile Leu Lys Gln Lys Phe Ile Glu Lys Gly 
                165                 170                 175     


Leu Asn Asp Arg Asp Leu Val Ile Leu Ser Ala Ala His Thr Ile Gly 
            180                 185                 190         


Thr Thr Ala Cys Phe Phe Met Thr Thr Arg Leu Tyr Asp Phe Ala Ser 
        195                 200                 205             


Ser Glu Gly Pro Asp Pro Ser Ile Asn Pro Ser Phe Leu Pro Glu Leu 
    210                 215                 220                 


Thr Ser Ala Cys Pro Lys Glu Gly Asn Pro Asn Asp Arg Leu Pro Met 
225                 230                 235                 240 


Asp His Gly Ser Gly Asp Ile Phe Asp Lys Gln Ile Phe Gln Asn Ile 
                245                 250                 255     


Arg Ser Gly Phe Ala Val Leu Gln Ser Asp Ala Lys Leu Met Asp Asp 
            260                 265                 270         


Pro Thr Thr Lys Gly Ile Val Asp Ser Tyr Phe Gly Leu Leu Ser Pro 
        275                 280                 285             


Leu Ile Gly Pro Ser Phe Glu Gly Asp Phe Val Lys Ser Met Val Arg 
    290                 295                 300                 


Met Gly Arg Ile Gly Val Lys Thr Gly Ser Ser Gly Asp Ile Arg Arg 
305                 310                 315                 320 


Val Cys Lys Ala Phe Asn 
                325     


<210>  68
<211>  328
<212>  PRT
<213>  Artemisia annua

<400>  68

Met Lys Gly Phe Trp Ser Leu Gly Leu Met Val Val Gly Val Leu Ser 
1               5                   10                  15      


Ile Leu Gly Ser Val Glu Gly Asp Leu Gln Met Gly Phe Tyr Ser Ser 
            20                  25                  30          


Ser Cys Pro Lys Ala Glu Lys Ile Val Gln Asp Phe Val Asn Gln His 
        35                  40                  45              


Ile Pro Asn Ala Pro Ser Leu Ala Ala Thr Leu Ile Arg Met Asn Phe 
    50                  55                  60                  


His Asp Cys Phe Val Arg Gly Cys Asp Gly Ser Val Leu Leu Asn Phe 
65                  70                  75                  80  


Thr Ser Ser Ser Gly Asn Gln Thr Glu Lys Val Ala Val Pro Asn Arg 
                85                  90                  95      


Thr Leu Arg Gly Phe Gly Phe Ile Asp Ala Ile Lys Ser Leu Ile Glu 
            100                 105                 110         


Ala Glu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Ile Ala Leu Ala 
        115                 120                 125             


Ala Arg Asp Ser Ile Val Leu Thr Gly Gly Pro Ser Trp Lys Val Pro 
    130                 135                 140                 


Thr Gly Arg Arg Asp Gly Leu Leu Ser Asn Ala Ser Glu Ala Leu Ala 
145                 150                 155                 160 


Gln Ile Pro Ala Pro Thr Asp Asn Ile Thr Ile Leu Ile Gln Lys Phe 
                165                 170                 175     


Ala Asn Lys Ser Leu Asp Leu Lys Asp Leu Val Leu Leu Ser Gly Ala 
            180                 185                 190         


His Thr Ile Gly Ile Ala His Cys Pro Ser Phe Ser Asn Arg Leu Tyr 
        195                 200                 205             


Asn Phe Thr Gly Val Gly Asp Arg Asp Pro Ser Leu Asp Ser Glu Tyr 
    210                 215                 220                 


Ala Asp Val Leu Arg Ser Thr Lys Cys Arg Thr Gln Asn Asp Asn Thr 
225                 230                 235                 240 


Thr Ile Val Glu Met Asp Pro Gly Ser Arg Lys Thr Phe Asp Leu Ser 
                245                 250                 255     


Tyr Tyr Thr Leu Leu Leu Lys Arg Arg Gly Leu Phe Glu Ser Asp Ser 
            260                 265                 270         


Ala Leu Thr Arg Asn Ser Asn Thr Leu Thr Tyr Ile Asn Gln Leu Leu 
        275                 280                 285             


Gln Gly Ser Leu Gln Asn Phe Phe Ser Glu Phe Ala Leu Ser Met Glu 
    290                 295                 300                 


Lys Met Asn Gln Ile Gly Val Lys Thr Gly Thr Thr Gly Glu Ile Arg 
305                 310                 315                 320 


Lys Asn Cys Ala Val Val Asn Ser 
                325             


<210>  69
<211>  318
<212>  PRT
<213>  Artemisia annua

<400>  69

Met Gly Ser Ser Ala Ile Val Lys Phe Ala Ile Val Met Phe Leu Val 
1               5                   10                  15      


Gly Val Ala Ser Ala Gln Leu Ser Thr Asn Phe Tyr Ala Lys Ser Cys 
            20                  25                  30          


Pro Asn Leu Phe Phe Ala Val Asn Ser Ala Val Arg Ser Ala Ile Ser 
        35                  40                  45              


Arg Glu Thr Arg Met Gly Ala Ser Leu Leu Arg Leu His Phe His Asp 
    50                  55                  60                  


Cys Phe Val Asn Gly Cys Asp Gly Ser Ile Leu Leu Asp Asp Thr Pro 
65                  70                  75                  80  


Ser Phe Thr Gly Glu Lys Asn Ala Ala Pro Asn Phe Arg Ser Ala Arg 
                85                  90                  95      


Gly Phe Asp Val Val Asp Asn Ile Lys Ser Ala Val Glu Arg Ala Cys 
            100                 105                 110         


Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Ile Thr Ala Arg Asp 
        115                 120                 125             


Ser Val His Ile Leu Gly Gly Pro Tyr Trp Asn Val Lys Leu Gly Arg 
    130                 135                 140                 


Arg Asp Ser Arg Thr Ala Ser Gln Ala Ala Ala Asn Asn Ser Ile Pro 
145                 150                 155                 160 


Pro Pro Thr Ser Ser Leu Ser Ala Leu Ile Ser Ser Phe Asn Arg Val 
                165                 170                 175     


Gly Leu Ser Ala Lys Asp Met Val Ala Leu Ser Gly Ser His Thr Ile 
            180                 185                 190         


Gly Gln Ala Arg Cys Thr Asn Phe Arg Ala Arg Ile Tyr Asn Glu Thr 
        195                 200                 205             


Asn Asn Leu Asp Ala Ser Phe Ala Thr Ser Arg Arg Ser Asn Cys Pro 
    210                 215                 220                 


Arg Ala Ser Gly Ser Gly Asp Asn Asn Leu Ala Pro Leu Asp Ile Gln 
225                 230                 235                 240 


Thr Pro Asn Ala Phe Asn Asn Asp Tyr Tyr Lys Asn Leu Ile Ala Lys 
                245                 250                 255     


Lys Gly Leu Leu His Ser Asp Gln Gln Leu Phe Asn Gly Gly Ser Ala 
            260                 265                 270         


Asp Ser Thr Val Arg Lys Tyr Ser Ser Asn Pro Arg Gln Phe Ser Ser 
        275                 280                 285             


Asp Phe Ala Ala Ala Met Ile Lys Met Gly Asp Phe Arg Pro Leu Thr 
    290                 295                 300                 


Gly Ser Ser Gly Glu Ile Arg Arg Asn Cys Arg Lys Pro Asn 
305                 310                 315             


<210>  70
<211>  449
<212>  PRT
<213>  Artemisia annua

<400>  70

Met Ala Ile Gln Lys His Asn Thr Leu Gly Leu Arg Phe Leu Leu Val 
1               5                   10                  15      


Ala Leu Leu Leu Asn Ile Ala Asn Gly Asn Asp Leu Lys Leu Gly Phe 
            20                  25                  30          


Tyr Lys Lys Thr Cys Pro Arg Ala Glu Ala Ile Val Lys Arg Thr Thr 
        35                  40                  45              


Ala Asn Phe Ile Ser Arg Ala Pro Ser Leu Ala Ala Pro Leu Leu Arg 
    50                  55                  60                  


Met His Phe His Asp Cys Phe Val Arg Gly Cys Asp Gly Ser Val Leu 
65                  70                  75                  80  


Leu Asn Ser Thr Lys Asn Asn Gln Ala Glu Lys Ala Gly Ile Pro Asn 
                85                  90                  95      


Leu Ser Leu Arg Gly Phe Gln Val Ile Asp Ala Ala Lys Thr Ala Val 
            100                 105                 110         


Glu Ala Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Leu 
        115                 120                 125             


Val Ala Arg Asp Ser Ile Gln Gln Ile Lys Gly Pro Tyr Trp Pro Val 
    130                 135                 140                 


Pro Leu Gly Arg Arg Asp Gly Arg Val Ser Ile Ala Ser Glu Ser Phe 
145                 150                 155                 160 


Thr Leu Pro Ala Pro Phe Ala Asn Ile Thr Thr Leu Lys Ser Gln Phe 
                165                 170                 175     


Lys Ser Arg Gly Leu Ser Val Lys Asp Leu Val Val Leu Ser Gly Gly 
            180                 185                 190         


His Thr Val Gly Val Ser His Cys Ser Thr Ile Ala Ser Arg Leu Tyr 
        195                 200                 205             


Asn Phe Thr Gly Lys Gly Asp Thr Asp Pro Thr Leu Asp Pro Lys Tyr 
    210                 215                 220                 


Val Pro His Leu Lys Ser Lys Cys Lys Pro Thr Asp Thr Thr Thr Leu 
225                 230                 235                 240 


Leu Glu Met Asp Pro Gly Ser Val Lys Thr Phe Asp Glu Asp Tyr Tyr 
                245                 250                 255     


Thr Ile Val Ser Lys Arg Arg Gly Leu Phe Glu Ser Asp Ala Ala Leu 
            260                 265                 270         


Leu Asn Asp Lys Gln Thr Ser Ala Tyr Val Lys Leu Gln Ala Lys Ser 
        275                 280                 285             


His Gly Ala Thr Phe Phe Lys Asp Phe Ser Asp Ser Met Val Lys Met 
    290                 295                 300                 


Gly Lys Ile Gly Val Leu Thr Gly Lys Asn Gly Gly His Thr Val Gly 
305                 310                 315                 320 


Val Ser His Cys Ser Thr Ile Ala Ser Arg Leu Tyr Asn Phe Thr Gly 
                325                 330                 335     


Lys Gly Asp Thr Asp Pro Thr Leu Asp Pro Lys Tyr Val Pro His Leu 
            340                 345                 350         


Lys Ser Lys Cys Lys Pro Thr Asp Thr Thr Thr Leu Leu Glu Met Asp 
        355                 360                 365             


Pro Gly Ser Val Lys Thr Phe Asp Glu Asp Tyr Tyr Thr Ile Val Ser 
    370                 375                 380                 


Lys Arg Arg Gly Leu Phe Glu Ser Asp Ala Ala Leu Leu Asn Asp Lys 
385                 390                 395                 400 


Gln Thr Ser Ala Tyr Val Lys Leu Gln Ala Lys Ser His Gly Ala Thr 
                405                 410                 415     


Phe Phe Lys Asp Phe Ser Asp Ser Met Val Lys Met Gly Lys Ile Gly 
            420                 425                 430         


Val Leu Thr Gly Lys Asn Gly Glu Ile Arg Lys His Cys Ala Leu Ile 
        435                 440                 445             


Asn 
    


<210>  71
<211>  383
<212>  PRT
<213>  Artemisia annua

<400>  71

Met Asp Ser Arg Lys Ser Ile Leu Leu Val Val Phe Leu Ala Thr Leu 
1               5                   10                  15      


Ile Thr Leu Ala Leu Gly Gln Thr Arg Val Gly Phe Tyr Arg Thr Ser 
            20                  25                  30          


Cys Pro Arg Val Glu Thr Ile Val Gln Thr Ala Val Arg Ser Ala Val 
        35                  40                  45              


Asn Ser Asn Pro Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe His 
    50                  55                  60                  


Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu Ile Asp Gly Ala 
65                  70                  75                  80  


Ser Ser Glu Lys Thr Ala Leu Pro Asn Ser Leu Leu Arg Gly Phe Glu 
                85                  90                  95      


Val Ile Asp Ala Ala Lys Thr Gln Leu Glu Thr Ala Cys Pro Gly Val 
            100                 105                 110         


Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val 
        115                 120                 125             


Gln Thr Gly Gly Ala Ser Trp Gln Val Pro Leu Gly Arg Arg Asp Gly 
    130                 135                 140                 


Leu Val Ser Arg Ala Ser Asp Thr Ala Ser Leu Pro Gly Phe Asn Glu 
145                 150                 155                 160 


Pro Ile Asn Ala Leu Ile Thr Lys Phe Ala Asp Lys Asn Leu Asn Thr 
                165                 170                 175     


Gln Asp Leu Val Thr Leu Ser Gly Ala His Thr Ile Gly Thr Ala Ala 
            180                 185                 190         


Cys Val Leu Phe Ser Tyr Arg Leu Tyr Asn Tyr Asn Asn Thr Asn Gly 
        195                 200                 205             


Pro Asp Pro Thr Ile Asp Pro Ser Phe Leu Pro Thr Leu Arg Asn Leu 
    210                 215                 220                 


Cys Pro Asn Gly Gly Asp Gly Thr Arg Arg Val Thr Leu Asp Thr Gly 
225                 230                 235                 240 


Ser Val Gly Asn Phe Asp Asn Ser Tyr Tyr Arg Asn Leu Arg Asn Arg 
                245                 250                 255     


Arg Gly Val Leu Glu Ser Asp Ala Ala Leu Trp Asn Asn Pro Ala Thr 
            260                 265                 270         


Gln Thr Leu Val Asn Arg Phe Leu Gly Ile Arg Gly Leu Ala Gly Leu 
        275                 280                 285             


Arg Phe Asn Val Glu Phe Gly Arg Ser Met Val Lys Met Gly Asn Ile 
    290                 295                 300                 


Glu Leu Lys Thr Gly Ser Gln Gly Glu Ile Arg Arg Gly Lys Arg Lys 
305                 310                 315                 320 


Asn Glu Thr Gly Ala Ile Arg Arg Ser Asn Cys Cys Ala Glu Val Ile 
                325                 330                 335     


Tyr Thr Glu Val Lys Pro Ala Pro Phe Lys Glu Lys Ile Val Gly Ile 
            340                 345                 350         


Tyr Lys Asn Leu Asp Asp Ala Ser Thr Thr Asn His Val Asn Pro Met 
        355                 360                 365             


Val Arg Ala Asp Val Glu Glu Ala Lys Asn Leu Glu Asn Thr Lys 
    370                 375                 380             


<210>  72
<211>  323
<212>  PRT
<213>  Artemisia annua

<400>  72

Met Lys Gly Tyr Cys Ser Ile Leu Val Ile Leu Ala Ile Leu Gly Leu 
1               5                   10                  15      


Val Gln Gly Asp Leu Lys Leu Gly Phe Tyr Lys Ser Ser Cys Pro Lys 
            20                  25                  30          


Ala Glu Lys Ile Val Gln Glu Tyr Val Asn Gln His Ile Pro Asn Ala 
        35                  40                  45              


Pro Ser Leu Ala Ala Ala Leu Ile Arg Met Asn Phe His Asp Cys Phe 
    50                  55                  60                  


Val Arg Gly Cys Asp Ala Ser Ile Leu Leu Asn Phe Thr Ser Ala Ser 
65                  70                  75                  80  


Gly Asn Gln Thr Glu Lys Val Ala Ile Pro Asn Gln Thr Val Arg Gly 
                85                  90                  95      


Phe Gly Phe Ile Asp Ala Ile Lys Ser Leu Val Glu Ala Ala Cys Pro 
            100                 105                 110         


Gly Val Val Ser Cys Ala Asp Ile Ile Ala Leu Ala Thr Arg Asp Ser 
        115                 120                 125             


Ile Val Ala Thr Gly Gly Pro Tyr Trp Lys Val Pro Thr Gly Arg Arg 
    130                 135                 140                 


Asp Gly Leu Ile Ser Asn Ala Ser Glu Ala Leu Ala Gln Ile Pro Ala 
145                 150                 155                 160 


Pro Phe Asp Asn Ile Thr Ser Leu Ile Gln Lys Phe Ala Ile Lys Thr 
                165                 170                 175     


Leu Asp Leu Lys Asp Leu Val Leu Leu Ser Gly Ala His Thr Ile Gly 
            180                 185                 190         


Ile Ala His Cys Pro Ser Phe Ser Asn Arg Leu Tyr Asn Phe Thr Gly 
        195                 200                 205             


Val Gly Asp Arg Asp Pro Ser Leu Asp Ser Glu Tyr Ala Asp Asn Leu 
    210                 215                 220                 


Gln Ser Arg Lys Cys Arg Thr Pro Asn Asp Asn Thr Thr Lys Val Glu 
225                 230                 235                 240 


Met Asp Pro Gly Ser Arg Lys Thr Phe Asp Leu Ser Tyr Tyr Ser Leu 
                245                 250                 255     


Leu Leu Lys Arg Arg Gly Leu Phe Glu Ser Asp Ser Ala Leu Thr Arg 
            260                 265                 270         


Asn Ser Asn Thr Leu Thr Tyr Ile Asn Gln Leu Leu Gln Gly Ser Leu 
        275                 280                 285             


Gln Asn Phe Phe Ser Glu Phe Ala Leu Ser Met Glu Lys Met Asn Glu 
    290                 295                 300                 


Ile Glu Val Lys Thr Gly Thr Ser Gly Glu Ile Arg Arg Asn Cys Ala 
305                 310                 315                 320 


Val Val Asn 
            


<210>  73
<211>  319
<212>  PRT
<213>  Artemisia annua

<400>  73

Met Ser Ile Leu Leu Phe Leu Leu Leu Ala Thr Leu Ala Thr Ser Ala 
1               5                   10                  15      


Leu Gly Gln Gly Thr Arg Val Gly Phe Tyr Arg Thr Ser Cys Pro Arg 
            20                  25                  30          


Ala Glu Ser Ile Val Gln Ser Ala Val Gln Ser Gly Ala Arg Ser Asn 
        35                  40                  45              


Pro Arg Ala Ala Pro Gly Ile Leu Arg Met Phe Phe His Asp Cys Phe 
    50                  55                  60                  


Val Asn Gly Cys Asp Gly Ser Ile Leu Ile Asp Gly Pro Ser Ala Glu 
65                  70                  75                  80  


Lys Thr Ala Val Pro Asn Val Pro Ile Arg Gly Phe Asp Val Ile Asp 
                85                  90                  95      


Ala Ala Lys Thr Gln Leu Glu Ala Thr Cys Pro Gly Val Val Ser Cys 
            100                 105                 110         


Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val Leu Ser Gly 
        115                 120                 125             


Gly Arg Arg Trp Glu Val Pro Thr Gly Arg Arg Asp Gly Leu Val Ser 
    130                 135                 140                 


Gln Ala Ser Asp Thr Ala Asn Leu Pro Ala Phe Asn Asp Pro Ile Ser 
145                 150                 155                 160 


Val Gln Ile Arg Lys Phe Ser Glu Lys Gly Leu Asn Thr Gln Asp Leu 
                165                 170                 175     


Val Thr Leu Val Gly Gly His Thr Ile Gly Thr Ala Ala Cys Ala Val 
            180                 185                 190         


Phe Ser Tyr Arg Leu Tyr Asn Phe Asn Asn Thr Asn Gly Pro Asp Pro 
        195                 200                 205             


Asp Ile Asn Gln Ala Phe Leu Pro Gln Leu Arg Ala Leu Cys Pro Asn 
    210                 215                 220                 


Gly Gly Glu Ala Thr Thr Arg Val Gly Leu Asp Thr Gly Ser Val Asn 
225                 230                 235                 240 


Ser Phe Asp Asn Ser Tyr Tyr Ala Asn Leu Arg Asn Gly Arg Gly Val 
                245                 250                 255     


Leu Glu Ser Asp Ser Lys Leu Trp Ser Asp Ser Thr Thr Gln Arg Phe 
            260                 265                 270         


Val Gln Arg Phe Leu Gly Val Arg Gly Leu Gln Gly Leu Arg Phe Asp 
        275                 280                 285             


Val Glu Phe Gly Arg Ser Met Val Lys Met Gly Asn Ile Glu Leu Lys 
    290                 295                 300                 


Thr Gly Ser Gln Gly Glu Ile Arg Arg Val Cys Thr Ala Thr Asn 
305                 310                 315                 


<210>  74
<211>  329
<212>  PRT
<213>  Artemisia annua

<400>  74

Met Asp Ser Lys Lys Ser Ile Leu Leu Val Leu Leu Leu Ala Thr Leu 
1               5                   10                  15      


Ile Thr Leu Ala Leu Gly Gln Thr Arg Val Gly Phe Tyr Gln Thr Ser 
            20                  25                  30          


Cys Pro Arg Val Glu Thr Ile Val Gln Thr Ala Val Arg Ser Ala Ile 
        35                  40                  45              


Asn Ser Asn Pro Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe His 
    50                  55                  60                  


Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu Ile Asp Gly Ala 
65                  70                  75                  80  


Ser Ser Glu Lys Thr Ala Pro Pro Asn Gly Phe Leu Arg Gly Phe Glu 
                85                  90                  95      


Val Ile Asp Ala Ala Lys Thr Gln Leu Glu Thr Thr Cys Pro Gly Val 
            100                 105                 110         


Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val 
        115                 120                 125             


Gln Gln Asn Phe Leu Thr Leu Gln Thr Gly Gly Ala Ser Trp Gln Val 
    130                 135                 140                 


Pro Leu Gly Arg Arg Asp Gly Leu Val Ser Arg Ala Ser Asp Thr Gly 
145                 150                 155                 160 


Ser Leu Pro Gly Phe Asn Glu Pro Leu Asn Ala Leu Ile Arg Lys Phe 
                165                 170                 175     


Ala Asp Lys Asn Leu Asn Thr Gln Asp Leu Val Thr Leu Ser Gly Ala 
            180                 185                 190         


His Thr Ile Gly Thr Ala Ser Cys Leu Thr Phe Ser Tyr Arg Leu Tyr 
        195                 200                 205             


Asn Tyr Asn Asn Thr Asn Gly Pro Asp Pro Ser Ile Asp Pro Thr Phe 
    210                 215                 220                 


Leu Pro Thr Leu Arg Asn Leu Cys Pro Asn Gly Gly Asp Gly Thr Arg 
225                 230                 235                 240 


Arg Val Thr Leu Asp Thr Gly Ser Val Gly Asn Phe Asp Asn Ser Tyr 
                245                 250                 255     


Tyr Ser Asn Leu Arg Asn Arg Arg Gly Val Leu Glu Ser Asp Ala Ala 
            260                 265                 270         


Leu Trp Asn Asn Pro Ala Thr Gln Thr Leu Val Asn Arg Phe Leu Gly 
        275                 280                 285             


Ile Arg Gly Leu Ala Gly Leu Thr Phe Asn Val Glu Phe Gly Arg Ser 
    290                 295                 300                 


Met Val Lys Met Gly Asn Ile Glu Leu Lys Thr Gly Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Arg Arg Val Cys Thr Ala Ile Asn 
                325                 


<210>  75
<211>  333
<212>  PRT
<213>  Artemisia annua

<400>  75

Met Glu Ala Ser Ser Leu Asn Lys Ile Leu Ile Met Thr Val Leu Leu 
1               5                   10                  15      


Leu Ala Thr Phe Thr Ser Phe Ala Leu Gly Gln Gly Asn Arg Val Phe 
            20                  25                  30          


Ser Arg Gly Gly Thr Arg Val Gly Phe Tyr Arg Ser Thr Cys Pro Arg 
        35                  40                  45              


Ala Glu Phe Ile Val Gln Ser Ala Val Gln Thr Ala Val Arg Ala Asn 
    50                  55                  60                  


Pro Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe His Asp Cys Phe 
65                  70                  75                  80  


Val Asn Gly Cys Asp Ala Ser Ile Leu Leu Asp Gly Ala Ser Thr Glu 
                85                  90                  95      


Lys Thr Ala Gly Pro Asn Ala Phe Leu Arg Gly Phe Glu Val Ile Asp 
            100                 105                 110         


Ala Ala Lys Ser Arg Leu Glu Thr Ala Cys Pro Gly Val Val Ser Cys 
        115                 120                 125             


Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val Leu Thr Gly 
    130                 135                 140                 


Gly His Ser Trp His Val Pro Leu Gly Arg Arg Asp Gly Leu Val Ser 
145                 150                 155                 160 


Arg Ala Ser Asp Thr Ala Thr Leu Pro Ala Phe Asn Asp Pro Met Thr 
                165                 170                 175     


Val Gln Ile Gln Lys Phe Ala Asp Lys Gly Leu Asn Ile Gln Asp Leu 
            180                 185                 190         


Val Ile Leu Val Gly Gly His Thr Ile Gly Thr Ala Ala Cys Ala Leu 
        195                 200                 205             


Phe Ser Tyr Arg Leu Tyr Asn Phe Asn Asn Thr Asn Ala Pro Asp Pro 
    210                 215                 220                 


Asp Ile Asn Gln Ala Phe Leu Pro Gln Leu Arg Ala Leu Cys Pro Asn 
225                 230                 235                 240 


Gly Gly Asn Ala Leu Thr Arg Val Ala Leu Asp Thr Gly Ser Val Asn 
                245                 250                 255     


Ser Phe Gly Asn Ser Phe Tyr Asp Asn Leu Arg Ile Gly Arg Gly Val 
            260                 265                 270         


Ile Glu Ser Asp Ala Lys Leu Trp Ser Asp Lys Arg Thr Gln Arg Phe 
        275                 280                 285             


Val Gln Gly Phe Thr Gly Gly Arg Ser Gly Phe Arg Phe Asn Ala Glu 
    290                 295                 300                 


Phe Gly Arg Ala Met Val Lys Met Gly Asn Ile Glu Val Lys Thr Gly 
305                 310                 315                 320 


Arg Gln Gly Gln Ile Arg Arg Val Cys Thr Ala Thr Asn 
                325                 330             


<210>  76
<211>  318
<212>  PRT
<213>  Artemisia annua

<400>  76

Met Gly Ser Ser Val Ile Val Lys Phe Ala Phe Val Met Phe Leu Val 
1               5                   10                  15      


Gly Val Ser Ser Ala Gln Leu Ser Thr Asn Phe Tyr Ala Lys Ser Cys 
            20                  25                  30          


Pro Asn Leu Phe Leu Ala Val Asn Ser Ala Val Arg Ser Ala Ile Ser 
        35                  40                  45              


Arg Glu Thr Arg Met Gly Ala Ser Leu Leu Arg Leu His Phe His Asp 
    50                  55                  60                  


Cys Phe Val Asn Gly Cys Asp Gly Ser Ile Leu Leu Asp Asp Thr Ser 
65                  70                  75                  80  


Ser Phe Thr Gly Glu Lys Asn Ala Ala Pro Asn Phe Arg Ser Ala Arg 
                85                  90                  95      


Gly Phe Asp Val Val Asp Asn Ile Lys Ser Ala Val Glu Arg Ala Cys 
            100                 105                 110         


Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Ile Thr Ala Arg Asp 
        115                 120                 125             


Ser Val His Ile Leu Gly Gly Pro Tyr Trp Asn Val Lys Leu Gly Arg 
    130                 135                 140                 


Arg Asp Ser Arg Thr Ala Ser Gln Ala Ala Ala Asn Asn Ser Ile Pro 
145                 150                 155                 160 


Pro Pro Thr Ser Ser Leu Ser Ala Leu Ile Ser Ser Phe Ser Arg Val 
                165                 170                 175     


Gly Leu Ser Ala Lys Asp Met Val Ala Leu Ser Gly Ser His Thr Ile 
            180                 185                 190         


Gly Gln Ala Arg Cys Thr Thr Phe Arg Ala Arg Ile Tyr Asn Glu Thr 
        195                 200                 205             


Asn Asn Leu Asp Ala Ser Phe Gly Ala Ser Arg Arg Ser Asn Cys Pro 
    210                 215                 220                 


Arg Ala Ser Gly Ser Gly Asp Asn Asn Leu Ala Pro Leu Asp Val Gln 
225                 230                 235                 240 


Thr Pro Asn Ala Phe Asn Asn Asp Tyr Tyr Lys Asn Leu Ile Ala Lys 
                245                 250                 255     


Lys Gly Leu Leu His Ser Asp Gln Gln Leu Phe Asn Gly Gly Ser Ala 
            260                 265                 270         


Asp Ser Thr Val Arg Gln Tyr Ser Ser Asn Pro Arg Gln Phe Ser Ser 
        275                 280                 285             


Asp Phe Ala Ala Ala Met Ile Lys Met Gly Asp Phe Arg Pro Leu Thr 
    290                 295                 300                 


Gly Ser Ser Gly Glu Ile Arg Arg Asn Cys Arg Arg Pro Asn 
305                 310                 315             


<210>  77
<211>  322
<212>  PRT
<213>  Artemisia annua

<400>  77

Met Ala Ile Gln Lys Gln Leu Ile Ala Val Leu Gln Leu Leu Leu Ile 
1               5                   10                  15      


Ala Leu Val Phe Asp Ile Ala Asn Gly Lys Gly Leu Asp Leu Gly Phe 
            20                  25                  30          


Tyr Arg Tyr Thr Cys Gln Arg Val Glu Ala Ile Val Arg Lys Thr Thr 
        35                  40                  45              


Ala Asn Tyr Ile His Arg Ala Pro Ser Leu Ala Ala Gly Leu Leu Arg 
    50                  55                  60                  


Met His Phe His Asp Cys Phe Val Arg Gly Cys Glu Gly Ser Val Leu 
65                  70                  75                  80  


Leu Asn Ser Thr Val Asn Asn Gln Ala Glu Lys Glu Gly Ile Pro Asn 
                85                  90                  95      


Leu Thr Leu Arg Gly Phe Gln Val Val Asp Ala Ala Lys Thr Ala Leu 
            100                 105                 110         


Glu Ala Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Leu 
        115                 120                 125             


Val Ala Arg Asp Ala Ile Tyr Gln Ile Lys Gly Pro Phe Trp Arg Val 
    130                 135                 140                 


Pro Leu Gly Arg Arg Asp Arg Arg Val Ser Ile Ala Asn Glu Ala Leu 
145                 150                 155                 160 


Thr Ser Leu Pro Ser Pro Phe Ala Asn Ile Thr Glu Leu Lys Ala Asn 
                165                 170                 175     


Phe Ala Ser Lys Gly Leu Asn Thr Lys Asp Leu Val Val Leu Ser Gly 
            180                 185                 190         


Arg His Thr Val Gly Val Ser His Cys Leu Val Ile Val Asn Arg Leu 
        195                 200                 205             


Tyr Asn Phe Thr Gly Lys Gly Asp Thr Asp Pro Ser Leu Asp Pro Lys 
    210                 215                 220                 


Phe Ile Pro Gln Leu Lys Ser Ile Cys Ser Pro Ile Asp Thr Thr Ser 
225                 230                 235                 240 


Val Leu Ala Met Asp Arg Thr Pro Thr Ser Phe Asp Glu Asp Tyr Tyr 
                245                 250                 255     


Thr Val Val Leu Arg Lys Arg Gly Leu Phe Gln Ser Asp Ala Ala Leu 
            260                 265                 270         


Leu Ile Asp Lys Gln Thr Ser Ala Tyr Val Lys Leu Gln Ser Lys Ser 
        275                 280                 285             


Phe Gly Tyr Thr Phe Phe Asn Asp Phe Ser Lys Ser Met Val Lys Met 
    290                 295                 300                 


Gly Lys Thr Gly Val Leu Thr Ser Ser Ala Gly Glu Ile Tyr Arg Thr 
305                 310                 315                 320 


Cys Ala 
        


<210>  78
<211>  319
<212>  PRT
<213>  Artemisia annua

<400>  78

Met Ser Ile Leu Leu Phe Phe Leu Leu Ala Thr Leu Ala Thr Ser Ala 
1               5                   10                  15      


Leu Gly Gln Gly Thr Arg Val Gly Phe Tyr Arg Thr Ser Cys Pro Arg 
            20                  25                  30          


Ala Glu Ser Ile Val Gln Ser Ala Val Gln Ser Gly Ala Arg Ser Asn 
        35                  40                  45              


Pro Arg Ala Ala Pro Gly Ile Leu Arg Met Phe Phe His Asp Cys Phe 
    50                  55                  60                  


Val Asn Gly Cys Asp Gly Ser Ile Leu Ile Asp Gly Pro Ser Ala Glu 
65                  70                  75                  80  


Lys Thr Ala Val Pro Asn Val Pro Ile Arg Gly Phe Glu Val Ile Asp 
                85                  90                  95      


Ala Ala Lys Thr Gln Leu Glu Ala Thr Cys Pro Gly Val Val Ser Cys 
            100                 105                 110         


Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val Leu Ser Gly 
        115                 120                 125             


Gly Arg Arg Trp Glu Val Pro Thr Gly Arg Arg Asp Gly Leu Val Ser 
    130                 135                 140                 


Gln Ala Ser Asp Thr Ala Asn Leu Pro Ala Phe Asn Asp Pro Ile Ser 
145                 150                 155                 160 


Val Gln Ile Arg Lys Phe Ser Glu Lys Gly Leu Asn Thr Gln Asp Leu 
                165                 170                 175     


Val Thr Leu Val Gly Gly His Thr Ile Gly Thr Ala Ala Cys Ala Val 
            180                 185                 190         


Phe Ser Tyr Arg Leu Tyr Asn Phe Asn Asn Thr Asn Gly Pro Asp Pro 
        195                 200                 205             


Asp Ile Asn Gln Ala Phe Leu Pro Gln Leu Arg Ala Leu Cys Pro Asn 
    210                 215                 220                 


Gly Gly Glu Ala Thr Thr Arg Val Gly Leu Asp Thr Gly Ser Val Asn 
225                 230                 235                 240 


Ser Phe Asp Asn Ser Tyr Tyr Ala Asn Leu Arg Asn Gly Arg Gly Val 
                245                 250                 255     


Leu Glu Ser Asp Ser Lys Leu Trp Ser Asp Ser Thr Thr Gln Arg Phe 
            260                 265                 270         


Val Gln Arg Phe Leu Gly Val Arg Gly Leu Gln Gly Leu Arg Phe Asp 
        275                 280                 285             


Val Glu Phe Gly Arg Ser Met Val Lys Met Gly Asn Ile Glu Leu Lys 
    290                 295                 300                 


Thr Gly Ser Gln Gly Glu Ile Arg Arg Val Cys Thr Ala Thr Asn 
305                 310                 315                 


<210>  79
<211>  520
<212>  PRT
<213>  Artemisia annua

<400>  79

Met Ala Arg Ser Ile Ile Met Leu Met Val Leu Ile Ser Val Met Ala 
1               5                   10                  15      


Ile Ala Asn Ala Ser Tyr Gly Ser Tyr Leu Tyr Pro Gln Phe Tyr Asp 
            20                  25                  30          


His Ser Cys Pro Gln Ala Lys Asn Ile Val Gln Ser Val Val Ala Lys 
        35                  40                  45              


Ala Val Ala Lys Glu Ala Arg Met Ala Ala Ser Leu Leu Arg Leu His 
    50                  55                  60                  


Phe His Asp Cys Phe Val Lys Gly Cys Asp Ala Ser Ile Leu Leu Asp 
65                  70                  75                  80  


Asn Ser Gly Thr Ile Ile Ser Glu Lys Gly Ser Val Pro Asn Arg Asn 
                85                  90                  95      


Ser Ala Arg Gly Phe Glu Val Ile Asp Glu Ile Lys Ala Ala Leu Glu 
            100                 105                 110         


Lys Ala Cys Pro Gln Thr Val Ser Cys Ala Asp Ile Met Ala Leu Ala 
        115                 120                 125             


Ala Arg Asp Ser Thr Val Leu Ala Gly Gly Pro Ser Trp Glu Val Pro 
    130                 135                 140                 


Leu Gly Arg Arg Asp Ser Leu Gly Ala Ser Leu Ser Gly Ser Asn Gln 
145                 150                 155                 160 


Asn Ile Pro Ala Pro Asn Asn Thr Phe Gln Thr Ile Leu Thr Lys Phe 
                165                 170                 175     


Lys Leu Lys Gly Leu Asp Ile Val Asp Phe Val Thr Leu Ser Gly Ser 
            180                 185                 190         


His Thr Ile Gly Asn Ala Arg Cys Thr Ser Phe Arg Gln Arg Leu Tyr 
        195                 200                 205             


Asn Asn Thr Gly Asn Gly Lys Pro Asp Leu Ser Leu Asp Gln Ser Tyr 
    210                 215                 220                 


Ala Ala Gln Leu Arg Gln Asn Cys Pro Arg Ser Gly Gly Asp Gln Asn 
225                 230                 235                 240 


Leu Phe Val Met Asp Pro Val Ser Pro Thr Lys Phe Asp Asn Asn Tyr 
                245                 250                 255     


Tyr Lys Asn Leu Ile Ala Ala Lys Gly Leu Leu Ser Ser Asp Glu Ile 
            260                 265                 270         


Leu Phe Thr Gln Asn Gln Gln Thr Met Gln Tyr Val Lys Gln Tyr Ala 
        275                 280                 285             


Ala Asn Gln Glu Leu Phe Phe Gln Gln Phe Ala Lys Ser Met Val Lys 
    290                 295                 300                 


Met Gly Asn Ile Thr Pro Leu Thr Ala Ser His Glu Thr Leu Tyr Met 
305                 310                 315                 320 


Ile Thr His Val Tyr Thr Ile Leu Glu Glu His Met Leu Ala Val Asp 
                325                 330                 335     


Thr Ser His Lys Leu Leu Ile Phe Asp Pro Ser Leu Leu Lys Tyr Gly 
            340                 345                 350         


Asn Lys Gln Leu Thr Leu Arg Thr Val Asp Cys Asp Ala Pro Asn Val 
        355                 360                 365             


Gly Phe Thr Thr Val Arg Glu Val Thr Tyr Ser Ser Leu Pro Tyr Pro 
    370                 375                 380                 


His Ser Phe Leu Asn Ser Leu Tyr Val Leu Ser Ser Phe Asp Gly Leu 
385                 390                 395                 400 


Val Cys Leu Ala Ser Pro Leu Thr Lys Glu Leu Ala Leu Leu Asn Pro 
                405                 410                 415     


Leu Thr Gly Ala Phe Lys Ser Leu Pro Glu Asn Ser Tyr Ser Pro His 
            420                 425                 430         


Phe Tyr Asn Arg Tyr Ser Asp Val Leu Gly Phe Tyr Met Asp Ser Phe 
        435                 440                 445             


Ser Asp Asp Tyr Lys Leu Leu His Ile Val Val Ser Lys Gly Phe Leu 
    450                 455                 460                 


Gly Ala Tyr Val Tyr Ser Leu Lys Met Asp Ser Trp Lys Lys Ile Glu 
465                 470                 475                 480 


Tyr Leu Val Asp Ser Ile Asp His Arg Ser Asp Tyr Ser Trp Thr Pro 
                485                 490                 495     


Ala Thr Leu Leu Gly Gln Cys Leu Tyr Phe Val Val Trp Glu Ser Ser 
            500                 505                 510         


Ser Glu Gly Leu Phe His Glu Ser 
        515                 520 


<210>  80
<211>  322
<212>  PRT
<213>  Artemisia annua

<400>  80

Met Ala Ser Arg Asn Val Ser Thr Thr Val Phe Phe Leu Leu Phe Leu 
1               5                   10                  15      


Ala Val Thr Asn Asn Thr Leu Cys Glu Ala Gln Leu Ser Thr Thr Phe 
            20                  25                  30          


Tyr Asp Arg Thr Cys Pro Asn Ala Leu Ser Thr Ile Arg Thr Ser Ile 
        35                  40                  45              


Arg Arg Ala Ile Ser Arg Glu Arg Arg Met Ala Ala Ser Ile Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser Ile Leu 
65                  70                  75                  80  


Leu Asp Asp Gly Pro Thr Ile Ile Ser Glu Lys Asn Ala Leu Pro Asn 
                85                  90                  95      


Lys Gly Ser Val Arg Gly Tyr Glu Val Ile Glu Ala Ala Lys Thr Glu 
            100                 105                 110         


Val Glu Lys Leu Cys Thr Gly Val Val Ser Cys Ala Asp Ile Leu Thr 
        115                 120                 125             


Val Ala Ala Arg Asp Ala Ser Glu Met Val Gly Gly Pro Ser Trp Ser 
    130                 135                 140                 


Val Lys Leu Gly Arg Arg Asp Ser Asp Thr Ala Ser Leu Val Leu Ala 
145                 150                 155                 160 


Glu Thr Gly Ala Leu Pro Ser Phe Lys Ala Pro Leu Asp Ser Leu Ile 
                165                 170                 175     


Ser Thr Phe Arg Asp Asn Gly Leu Ser Ala Arg Asp Met Val Ala Leu 
            180                 185                 190         


Ser Gly Ala His Thr Ile Gly Gln Ala Gln Cys Phe Leu Phe Arg Asp 
        195                 200                 205             


Arg Ile Tyr Ser Asn Gly Ser Asp Ile Asp Ala Gly Phe Ala Ser Thr 
    210                 215                 220                 


Arg Arg Arg Arg Cys Pro Ile Asn Asp Gly Asn Glu Asn Leu Ala Ala 
225                 230                 235                 240 


Leu Asp Leu Val Thr Pro Asn Ser Phe Asp Asn Asn Tyr Phe Lys Asn 
                245                 250                 255     


Leu Leu Gln Lys Lys Gly Leu Leu Glu Thr Asp Gln Val Leu Phe Ser 
            260                 265                 270         


Gly Gly Ser Thr Asp Ser Ile Val Thr Glu Tyr Ser Arg Ser Pro Ala 
        275                 280                 285             


Lys Phe Lys Ser Asp Phe Ala Ala Ala Met Val Lys Met Gly Glu Ile 
    290                 295                 300                 


Arg Thr Leu Thr Gly Gln Gln Gly Val Ile Arg Arg Ile Cys Gly Ala 
305                 310                 315                 320 


Leu Pro 
        


<210>  81
<211>  328
<212>  PRT
<213>  Artemisia annua

<400>  81

Met Arg Gly Phe Trp Ser Phe Gly Ile Ile Val Leu Gly Phe Ile Ser 
1               5                   10                  15      


Ile Leu Gly Ser Val Gln Gly Gly Leu Gln Ile Gly Phe Tyr Ser Ser 
            20                  25                  30          


Ser Cys Pro Lys Ala Glu Lys Ile Ile Lys Asp Tyr Val Asn Gln His 
        35                  40                  45              


Ile Pro Asn Ala Pro Ser Leu Ala Ala Thr Leu Ile Arg Met His Phe 
    50                  55                  60                  


His Asp Cys Phe Val Arg Gly Cys Asp Ala Ser Ile Leu Leu Asn Phe 
65                  70                  75                  80  


Thr Ser Ala Ser Gly Asn Gln Thr Glu Lys Val Ala Ile Pro Asn Gln 
                85                  90                  95      


Thr Val Arg Gly Phe Asp Phe Ile Asp Arg Ile Lys Ser Leu Leu Glu 
            100                 105                 110         


Ala Glu Cys Pro Gly Ile Val Ser Cys Ala Asp Ile Ile Ser Leu Ala 
        115                 120                 125             


Ala Arg Asp Ser Ile Val Val Thr Gly Gly Pro Ser Trp Lys Val Pro 
    130                 135                 140                 


Thr Gly Arg Arg Asp Gly Leu Leu Ser Asn Ala Ser Glu Ala Leu Ala 
145                 150                 155                 160 


Gln Ile Pro Ala Pro Phe Asp Asn Ile Thr Ile Leu Thr Gln Lys Phe 
                165                 170                 175     


Val Asn Lys Ser Leu Asn Leu Lys Asp Leu Val Leu Leu Ser Gly Ala 
            180                 185                 190         


His Thr Ile Gly Ile Ala His Cys Pro Ser Phe Ser Asn Arg Leu Tyr 
        195                 200                 205             


Asn Phe Thr Gly Arg Gly Asp Gln Asp Pro Ser Leu Asp Ser Glu Tyr 
    210                 215                 220                 


Ala Asp Asn Leu Arg Ser Arg Lys Cys Thr Thr Pro Asn Asp Asn Thr 
225                 230                 235                 240 


Thr Ile Val Glu Met Asp Pro Gly Ser Arg Lys Thr Phe Asp Leu Ser 
                245                 250                 255     


Tyr Tyr Ser Leu Leu Leu Lys Arg Arg Gly Leu Phe Glu Ser Asp Ser 
            260                 265                 270         


Ala Leu Thr Arg Asn Ser Asn Thr Leu Thr Phe Val Asn Gln Leu Leu 
        275                 280                 285             


Gln Gly Ser Leu Gln Asn Phe Phe Ser Glu Phe Ala Leu Ser Met Glu 
    290                 295                 300                 


Lys Met Asn Gln Ile Gly Val Lys Thr Gly Thr Thr Gly Glu Ile Arg 
305                 310                 315                 320 


Arg Asn Cys Ala Val Val Asn Ser 
                325             


<210>  82
<211>  333
<212>  PRT
<213>  Artemisia annua

<400>  82

Met Gly Ala Ser Ser Leu Asn Lys Ile Leu Ile Val Thr Val Leu Leu 
1               5                   10                  15      


Leu Ala Thr Phe Thr Ser Leu Ala Leu Gly Gln Gly Asn Arg Trp Phe 
            20                  25                  30          


Ser Arg Gly Gly Thr Arg Val Gly Phe Tyr Lys Ser Thr Cys Pro Arg 
        35                  40                  45              


Ala Glu Phe Ile Val Gln Ser Ala Val Gln Thr Ala Val Arg Ala Asn 
    50                  55                  60                  


Pro Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe His Asp Cys Phe 
65                  70                  75                  80  


Val Asn Gly Cys Asp Ala Ser Ile Leu Leu Asp Gly Ala Ser Thr Glu 
                85                  90                  95      


Lys Thr Ala Gly Pro Asn Ala Phe Leu Arg Gly Phe Glu Val Ile Asp 
            100                 105                 110         


Ala Ala Lys Ser Arg Leu Glu Thr Ala Cys Pro Gly Val Val Ser Cys 
        115                 120                 125             


Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val Leu Thr Gly 
    130                 135                 140                 


Gly His Ser Trp His Val Pro Leu Gly Arg Arg Asp Gly Leu Val Ser 
145                 150                 155                 160 


Arg Ala Ser Asp Thr Ala Thr Leu Pro Ala Phe Asn Asp Pro Met Thr 
                165                 170                 175     


Val Gln Ile Gln Lys Phe Ala Asp Lys Gly Leu Asn Ile Gln Asp Leu 
            180                 185                 190         


Val Ile Leu Val Gly Gly His Thr Ile Gly Thr Ala Ala Cys Ala Leu 
        195                 200                 205             


Phe Ser Tyr Arg Leu Tyr Asn Phe Asn Asn Thr Asn Ala Pro Asp Pro 
    210                 215                 220                 


Asp Ile Asn Gln Ala Phe Leu Pro Gln Leu Arg Ala Leu Cys Pro Asn 
225                 230                 235                 240 


Gly Gly Asn Ala Leu Arg Arg Val Ala Leu Asp Thr Gly Ser Val Asn 
                245                 250                 255     


Ser Phe Gly Asn Ser Phe Tyr Asp Asn Leu Arg Ile Gly Arg Gly Val 
            260                 265                 270         


Val Glu Ser Asp Ala Lys Leu Trp Ser Asp Arg Arg Thr Gln Arg Phe 
        275                 280                 285             


Val Gln Gly Phe Thr Gly Arg Arg Ser Gly Phe Lys Phe Asn Ala Lys 
    290                 295                 300                 


Phe Gly Arg Ala Met Val Lys Met Gly Asn Ile Glu Val Lys Thr Gly 
305                 310                 315                 320 


Arg Gln Gly Glu Ile Arg Arg Val Cys Thr Ala Thr Asn 
                325                 330             


<210>  83
<211>  320
<212>  PRT
<213>  Artemisia annua

<400>  83

Met Asn Ile Ile Ser Leu Leu Ala Leu Phe Val Phe Leu Ile Phe Thr 
1               5                   10                  15      


Val Ala Thr Ala Ser Ser Asp Ser Gly Leu Ser Thr Lys Tyr Tyr Asp 
            20                  25                  30          


Arg Val Cys Pro Gln Ala Leu Pro Thr Ile Lys Arg Val Val Glu Asp 
        35                  40                  45              


Ala Val Ala Gln Glu Arg Arg Met Gly Ala Ser Leu Leu Arg Leu His 
    50                  55                  60                  


Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Val Leu Leu Asp 
65                  70                  75                  80  


Gln Thr Ser Thr Ile Asp Ser Glu Lys Asn Ala Leu Ala Asn Ala Asn 
                85                  90                  95      


Ser Ala Arg Gly Phe Glu Val Ile Asp Arg Ile Lys Ser Glu Val Asp 
            100                 105                 110         


Lys Ile Cys Gly Arg Pro Ile Val Ser Cys Ala Asp Ile Leu Thr Leu 
        115                 120                 125             


Val Ala Arg Asp Ser Val Val Ala Leu Gly Gly Pro Ser Trp Lys Val 
    130                 135                 140                 


Lys Leu Gly Arg Arg Asp Ser Thr Thr Ala Ser Arg Ala Thr Ala Asn 
145                 150                 155                 160 


Ala Asn Leu Pro Ser Pro Phe Met Asp Leu Pro Ala Leu Ile Lys Asn 
                165                 170                 175     


Phe Lys Asp Gln Gly Leu Asp Glu Lys Asp Leu Val Leu Leu Ser Gly 
            180                 185                 190         


Ala His Thr Leu Gly Phe Ala Gln Cys Phe Thr Phe Arg Asp Arg Ile 
        195                 200                 205             


Tyr Asn Asp Thr Asn Ile Asp Pro Ala Phe Ala Gly His Leu Arg Thr 
    210                 215                 220                 


Ile Cys Pro Arg Val Gly Gly Asp Ser Asn Leu Ala Pro Leu Asp Pro 
225                 230                 235                 240 


Thr Pro Ser Ser Phe Asp Thr Lys Tyr Phe Asn Asn Leu Ile Arg Lys 
                245                 250                 255     


Arg Gly Val Leu Ile Ser Asp Gln Val Leu Leu Asn Gly Arg Lys Thr 
            260                 265                 270         


Asn Glu Leu Val Ser Glu Tyr Asn Glu Asp Lys Thr Lys Phe Phe Lys 
        275                 280                 285             


Asp Phe Ser Lys Ser Met Ile Lys Met Gly Lys Ile Asp Leu Leu Thr 
    290                 295                 300                 


Gly Asn Arg Gly Gln Val Arg His Asn Cys Arg Arg Val Asn Ser Gln 
305                 310                 315                 320 


<210>  84
<211>  322
<212>  PRT
<213>  Artemisia annua

<400>  84

Met Asp Ser Lys Lys Ser Ile Leu Tyr Val Phe Leu Leu Ala Thr Leu 
1               5                   10                  15      


Ile Thr Leu Ala Leu Gly Gln Ala Arg Ile Gly Phe Tyr Gln Thr Ser 
            20                  25                  30          


Cys Pro Gln Val Glu Thr Ile Val Gln Thr Ala Val Gln Ser Ala Ile 
        35                  40                  45              


Asn Ser Asn Pro Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe His 
    50                  55                  60                  


Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu Ile Asp Gly Ala 
65                  70                  75                  80  


Ser Ser Glu Lys Thr Ala Leu Pro Asn Ser Leu Leu Arg Gly Phe Glu 
                85                  90                  95      


Val Ile Asp Ala Ala Lys Thr Gln Leu Glu Thr Ala Cys Pro Gly Val 
            100                 105                 110         


Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val 
        115                 120                 125             


Gln Thr Gly Gly Ala Ser Trp Gln Val Pro Leu Gly Arg Arg Asp Gly 
    130                 135                 140                 


Leu Val Ser Arg Ala Ser Asp Ala Ala Ser Leu Pro Gly Phe Asn Glu 
145                 150                 155                 160 


Pro Ile Asn Ala Leu Ile Thr Lys Phe Ser Asp Lys Asn Leu Asn Ile 
                165                 170                 175     


Gln Asp Leu Val Thr Leu Ser Gly Ala His Thr Ile Gly Thr Ala Ala 
            180                 185                 190         


Cys Val Leu Phe Ser Tyr Arg Leu Tyr Asn Tyr Asn Asn Thr Asn Gly 
        195                 200                 205             


Pro Asp Pro Thr Ile Asp Pro Asp Phe Leu Pro Thr Leu Arg Asn Leu 
    210                 215                 220                 


Cys Pro Asn Gly Gly Asp Gly Thr Arg Arg Val Ala Leu Asp Thr Gly 
225                 230                 235                 240 


Ser Val Gly Asn Phe Asp Thr Ser Tyr Tyr Ser Asn Leu Arg Asn Gly 
                245                 250                 255     


Arg Gly Val Leu Glu Ser Asp Ala Ala Leu Met Asn Asn Pro Ala Thr 
            260                 265                 270         


Lys Ala Leu Val Asn Arg Phe Leu Gly Ile Arg Gly Met Ala Gly Leu 
        275                 280                 285             


Ser Phe Asn Val Glu Phe Gly Arg Ser Met Val Arg Met Gly Asn Ile 
    290                 295                 300                 


Glu Leu Lys Thr Gly Asn Gln Gly Glu Ile Arg Arg Val Cys Thr Thr 
305                 310                 315                 320 


Thr Asn 
        


<210>  85
<211>  318
<212>  PRT
<213>  Artemisia annua

<400>  85

Met Arg Tyr Ile Val Thr Lys Met Met Met Val Leu Val Thr Met Val 
1               5                   10                  15      


Val Met Leu Arg His Cys Asn Gly Leu Asn Met Asn Tyr Tyr Met Met 
            20                  25                  30          


Asn Gly Cys Pro Met Ala Asp Phe Ile Val Lys Asn Thr Val Asn Ala 
        35                  40                  45              


Ala Leu Arg Ala Asp Pro Thr Leu Ala Ala Gly Leu Ile Arg Met His 
    50                  55                  60                  


Phe His Asp Cys Phe Ile Gln Gly Cys Asp Ala Ser Ile Leu Leu Asp 
65                  70                  75                  80  


Ser Thr Asp Asp Asn Thr Ala Glu Lys Asp Ser Pro Ala Asn Leu Ser 
                85                  90                  95      


Leu Arg Gly Tyr Lys Val Ile Asp Asp Ala Lys Gln Glu Leu Glu Ser 
            100                 105                 110         


Arg Cys Pro Gly Val Val Ser Cys Ala Asp Ile Val Ala Met Ala Ala 
        115                 120                 125             


Arg Asp Ala Val Phe Phe Ala Gly Gly Pro Val Tyr Glu Ile Pro Lys 
    130                 135                 140                 


Gly Arg Lys Asp Gly Thr Arg Ser Lys Ile Glu Asp Thr Arg Asn Leu 
145                 150                 155                 160 


Pro Pro Pro Thr Phe Asn Ala Ser Glu Leu Ile Thr Met Phe Gly Gln 
                165                 170                 175     


His Gly Phe Thr Ala Gln Glu Met Val Ala Leu Ser Gly Gly His Thr 
            180                 185                 190         


Leu Gly Val Ala Arg Cys Ala Ser Phe Lys Asn Arg Leu Lys Ser Phe 
        195                 200                 205             


Asp Ser Thr His Asp Val Asp Pro Ser Ile Asp Thr Gln Phe Val Lys 
    210                 215                 220                 


Thr Leu Ala Lys Thr Cys Asn Gly Gly Asp Asn Ala Glu Gln Pro Phe 
225                 230                 235                 240 


Asp Gln Thr Arg Asn Met Phe Asp Asn Asn Tyr Tyr Asn Gly Leu Gln 
                245                 250                 255     


Arg Gln Ala Gly Val Leu Ser Ser Asp Gln Thr Leu Met Thr Asp Pro 
            260                 265                 270         


Lys Thr Arg Asn Ile Val Asn Ala Tyr Ala Phe Asn Gln Ala Met Phe 
        275                 280                 285             


Phe Phe Asp Phe Gln Gln Ala Met Val Lys Met Gly Leu Leu Asp Val 
    290                 295                 300                 


Lys Glu Thr Gly Gln Val Arg Gln Asn Cys Arg Lys Ile Asn 
305                 310                 315             


<210>  86
<211>  322
<212>  PRT
<213>  Artemisia annua

<400>  86

Met Tyr Ser Lys Asn Ser Ile Leu Tyr Val Val Leu Leu Ala Thr Leu 
1               5                   10                  15      


Ile Thr Leu Ala Leu Gly Gln Ala Gln Ile Gly Phe Tyr Gln Thr Ser 
            20                  25                  30          


Cys Pro Gln Val Glu Thr Ile Val Gln Thr Ala Val Gln Ser Ala Ile 
        35                  40                  45              


Asn Ser Asn Pro Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe His 
    50                  55                  60                  


Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu Ile Asp Gly Ala 
65                  70                  75                  80  


Ser Ser Glu Lys Thr Ala Leu Pro Asn Ser Leu Leu Arg Gly Phe Glu 
                85                  90                  95      


Val Ile Asp Ala Ala Lys Thr Gln Leu Glu Thr Ala Cys Pro Gly Val 
            100                 105                 110         


Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val 
        115                 120                 125             


Gln Thr Gly Gly Ala Ser Trp Gln Val Pro Leu Gly Arg Arg Asp Gly 
    130                 135                 140                 


Leu Val Ser Arg Ala Ser Asp Ala Ala Ser Leu Pro Gly Phe Asn Glu 
145                 150                 155                 160 


Pro Ile Asn Ala Leu Ile Thr Lys Phe Ala Asp Lys Asn Leu Asn Ile 
                165                 170                 175     


Gln Asp Leu Val Thr Leu Ser Gly Ala His Thr Ile Gly Thr Ala Ala 
            180                 185                 190         


Cys Val Leu Phe Ser Tyr Arg Leu Tyr Asn Tyr Asn Asn Thr Asn Gly 
        195                 200                 205             


Pro Asp Pro Thr Ile Asp Pro Asp Phe Leu Pro Thr Leu Arg Asn Leu 
    210                 215                 220                 


Cys Pro Asn Gly Gly Asp Gly Thr Arg Arg Val Ala Leu Asp Thr Gly 
225                 230                 235                 240 


Ser Val Gly Asn Phe Asp Thr Ser Tyr Tyr Ser Asn Leu Arg Asn Gly 
                245                 250                 255     


Arg Gly Val Leu Glu Ser Asp Ala Ala Leu Met Asn Asn Pro Ala Thr 
            260                 265                 270         


Gln Ala Leu Val Asn Arg Phe Leu Gly Ile Arg Gly Met Ala Gly Leu 
        275                 280                 285             


Ser Phe Asn Val Glu Phe Gly Arg Ser Met Val Arg Met Gly Asn Ile 
    290                 295                 300                 


Glu Leu Lys Thr Gly Asn Gln Gly Glu Ile Arg Arg Val Cys Thr Thr 
305                 310                 315                 320 


Thr Asn 
        


<210>  87
<211>  321
<212>  PRT
<213>  Artemisia annua

<400>  87

Met Gly Tyr Arg Asn Tyr Phe Ala Ile Met Phe Phe Leu Leu Phe Leu 
1               5                   10                  15      


Ser Val Thr Thr Asn Thr Pro Cys Lys Ala Gln Leu Ser Thr Lys Phe 
            20                  25                  30          


Tyr Asp Asp Thr Cys Pro Asn Ala Leu Arg Thr Ile Arg Asn Thr Ile 
        35                  40                  45              


Arg Thr Ser Ile Ser Arg Glu Arg Arg Met Ala Ala Ser Leu Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser Ile Leu 
65                  70                  75                  80  


Leu Asp Asp Ala Pro Met Ile Ile Ser Glu Lys Asn Ala Leu Pro Asn 
                85                  90                  95      


Lys Gly Ser Val Arg Gly Phe Glu Val Ile Glu Ala Ala Lys Ala Lys 
            100                 105                 110         


Val Glu Lys Leu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Thr 
        115                 120                 125             


Val Ala Ala Arg Asp Ala Ser Glu Met Val Gly Gly Pro Ser Trp Ser 
    130                 135                 140                 


Val Lys Leu Gly Arg Arg Asp Ser Thr Thr Ala Ser Leu Val Gln Ala 
145                 150                 155                 160 


Glu Thr Ser Leu Pro Ser Phe Met Ala Pro Leu Glu Ser Leu Ile Ser 
                165                 170                 175     


Ser Phe Lys Ala Gln Gly Leu Asp Ala Arg Asp Leu Val Ala Leu Ser 
            180                 185                 190         


Gly Ala His Thr Ile Gly Gln Ala Gln Cys Val Leu Phe Arg Asp Arg 
        195                 200                 205             


Ile Tyr Asn Asn Gly Ser His Ile Asp Ala Gly Phe Ala Arg Lys Arg 
    210                 215                 220                 


Arg His His Cys Pro Lys Asn Glu Gly Asn Gly Asn Leu Ala Pro Leu 
225                 230                 235                 240 


Asp Leu Val Thr Pro Asn Ser Phe Asp Asn Asn Tyr Phe Lys Asn Leu 
                245                 250                 255     


Ile Gln Lys Lys Gly Leu Leu Glu Ser Asp Gln Val Leu Tyr Ser Gly 
            260                 265                 270         


Gly Ser Thr Asp Lys Ile Val Leu Glu Tyr Ser Arg Asn Pro Lys Lys 
        275                 280                 285             


Phe Lys Ser Asp Phe Ala Ala Ala Met Ile Lys Met Ser Glu Ile Lys 
    290                 295                 300                 


Pro Leu Thr Gly His Lys Gly Val Ile Arg Arg Val Cys Gly Ala Leu 
305                 310                 315                 320 


Pro 
    


<210>  88
<211>  321
<212>  PRT
<213>  Artemisia annua

<400>  88

Met Ile Ile Phe Phe Thr Phe Leu Ile Gly Phe Thr Glu Ala Gln Leu 
1               5                   10                  15      


Lys Val Gly Phe Tyr Asn Lys Val Cys Pro Ala Ala Glu Thr Val Val 
            20                  25                  30          


Ala Asn Val Val Lys Asp Ala Thr Lys Ser Asp Pro Gln Thr Pro Ala 
        35                  40                  45              


Phe Met Leu Arg Leu His Phe His Asp Cys Phe Val Glu Gly Cys Asp 
    50                  55                  60                  


Gly Ser Ile Leu Ile Asp Asn Gly Asp Asn Ser Glu Arg Thr Ala Pro 
65                  70                  75                  80  


Gly His Ile Gly Leu Gln Gly Phe Lys Val Ile Glu Asn Ala Lys Ala 
                85                  90                  95      


Gln Leu Glu Ile Met Cys Pro Gly Val Val Ser Cys Ala Asp Ile Val 
            100                 105                 110         


Ala Met Ala Ala Arg Asp Ala Val Ala Leu Leu Leu Phe Phe Asp Ser 
        115                 120                 125             


His Gly Pro Val Tyr Gln Val Glu Thr Gly Arg Lys Asp Gly Leu Val 
    130                 135                 140                 


Ser Arg Met Glu Leu Ala Ala Arg Met Pro Asp Val Gln Asp Ser Ile 
145                 150                 155                 160 


Gln Ile Leu Lys Gln Lys Phe Ile Glu Lys Gly Leu Asn Asp Ser Asp 
                165                 170                 175     


Leu Val Ile Leu Ser Ala Ala His Thr Ile Gly Lys Ala Ala Cys Phe 
            180                 185                 190         


Phe Met Phe Lys Arg Leu Tyr Asn Phe Ser Ser Ser Gly Gly Pro Asp 
        195                 200                 205             


Pro Ser Ile Asn Pro Ser Phe Leu Pro Glu Leu Thr Ser Ala Cys Pro 
    210                 215                 220                 


Glu Gly Gly Asp Ala Gly His Arg Leu Pro Met Asp His Gly Ser Gly 
225                 230                 235                 240 


Glu Ile Phe Asp Lys Gln Ile Phe Gln Asn Ile Arg Ser Gly Phe Ala 
                245                 250                 255     


Val Leu Gln Ser Asp Ala Gln Leu Met Asp Asp Pro Thr Thr Lys Glu 
            260                 265                 270         


Ile Val Asp Ser Tyr Phe Gly Leu Leu Ser Pro Leu Pro Gly Pro Ser 
        275                 280                 285             


Phe Glu Ser Asp Phe Met Ser Ser Met Val Arg Met Gly Arg Ile Gly 
    290                 295                 300                 


Val Lys Thr Gly Ser Ser Gly Asn Ile Arg Arg Val Cys Asn Ala Phe 
305                 310                 315                 320 


Asn 
    


<210>  89
<211>  320
<212>  PRT
<213>  Artemisia annua

<400>  89

Met Met Leu Val Met Ile Ile Leu Phe Lys Phe Leu Ile Val Phe Thr 
1               5                   10                  15      


Glu Ala Gln Leu Lys Val Gly Phe Tyr Asn Lys Val Cys Pro Ala Ala 
            20                  25                  30          


Glu Thr Val Val Ala Asn Val Val Lys Asp Ala Thr Lys Ser Asp Pro 
        35                  40                  45              


Gln Thr Pro Ala Phe Met Leu Arg Leu His Phe His Asp Cys Phe Val 
    50                  55                  60                  


Glu Gly Cys Asp Gly Ser Ile Leu Ile Asp Asn Gly Val Asn Ser Glu 
65                  70                  75                  80  


Arg Ala Ala Asn Gly His Gln Gly Val Leu Gly Tyr Asp Val Ile Glu 
                85                  90                  95      


Asn Ala Lys Ala Gln Leu Glu Ser Met Cys Pro Ser Val Val Ser Cys 
            100                 105                 110         


Ala Asp Ile Val Ala Met Ala Ala Arg Asp Ala Val Ala Leu Ser His 
        115                 120                 125             


Gly Pro Val Tyr Gln Val Glu Thr Gly Arg Lys Asp Gly Leu Val Ser 
    130                 135                 140                 


Arg Ile Glu Leu Ala Ala Arg Met Pro Asp Val Gln Asp Ser Ile Gln 
145                 150                 155                 160 


Ile Leu Lys Gln Lys Phe Ile Glu Lys Gly Leu Asn Asp Lys Asp Leu 
                165                 170                 175     


Val Ile Leu Ser Ala Ala His Thr Ile Gly Thr Ser Ala Cys Phe Phe 
            180                 185                 190         


Met Thr Thr Arg Leu Tyr Asp Phe Ala Ser Ser Gly Gly Pro Asp Pro 
        195                 200                 205             


Ser Ile Asn Ala Ser Phe Leu Pro Glu Leu Thr Ser Ala Cys Pro Lys 
    210                 215                 220                 


Gly Gly Asn Pro Asn Asp Arg Leu Pro Met Asp His Gly Ser Gly Asp 
225                 230                 235                 240 


Ile Phe Asp Lys Gln Ile Phe Gln Asn Ile Arg Ser Gly Phe Ala Val 
                245                 250                 255     


Leu Gln Ser Asp Ala Lys Leu Met Asp Asp Pro Thr Thr Lys Gly Ile 
            260                 265                 270         


Val Asp Ser Tyr Phe Gly Leu Leu Ser Pro Leu Thr Gly Pro Ser Phe 
        275                 280                 285             


Glu Gly Asp Phe Met Ser Ser Met Val Arg Met Gly Arg Ile Gly Phe 
    290                 295                 300                 


Lys Thr Gly Ser Thr Gly Asn Ile Arg Arg Val Cys Lys Ala Phe Asn 
305                 310                 315                 320 


<210>  90
<211>  261
<212>  PRT
<213>  Artemisia annua

<400>  90

Met His Phe His Asp Cys Phe Val Arg Gly Cys Asp Gly Ser Val Leu 
1               5                   10                  15      


Leu Asn Ser Thr Ala Asn Asn Gln Ala Glu Lys Glu Gly Ile Pro Asn 
            20                  25                  30          


Leu Thr Leu Arg Gly Phe Gln Val Val Asp Ala Ala Lys Thr Ala Leu 
        35                  40                  45              


Glu Ala Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Leu 
    50                  55                  60                  


Val Ala Arg Asp Ala Ile Tyr Gln Ile Lys Gly Pro Phe Trp Pro Val 
65                  70                  75                  80  


Pro Leu Gly Arg Arg Asp Gly Arg Val Ser Ile Ala Asn Glu Ala Leu 
                85                  90                  95      


Thr Ser Leu Pro Ser Pro Phe Ala Asn Ile Thr Glu Leu Lys Ala Asn 
            100                 105                 110         


Phe Ala Ser Lys Gly Leu Asn Thr Lys Asp Leu Val Val Leu Ser Gly 
        115                 120                 125             


Gly His Thr Val Gly Val Ser His Cys Pro Val Ile Val Asn Arg Leu 
    130                 135                 140                 


Tyr Asn Phe Thr Gly Lys Gly Asp Thr Asp Pro Ser Leu Asp Pro Lys 
145                 150                 155                 160 


Phe Ile Pro Gln Leu Lys Ser Ile Cys Ser Pro Thr Asp Thr Thr Ser 
                165                 170                 175     


Val Leu Ala Met Asp Arg Thr Pro Arg Ser Phe Asp Glu Asp Tyr Tyr 
            180                 185                 190         


Thr Val Val Leu Arg Lys Arg Gly Leu Phe Gln Ser Asp Ala Ala Leu 
        195                 200                 205             


Leu Asn Asp Lys Gln Thr Ser Ala Tyr Val Lys Leu Gln Ser Lys Ser 
    210                 215                 220                 


Phe Gly Tyr Thr Phe Phe Asn Asp Phe Ser Lys Ser Met Val Lys Met 
225                 230                 235                 240 


Gly Lys Ile Gly Val Leu Thr Gly Ser Ala Gly Glu Ile Arg Arg Thr 
                245                 250                 255     


Cys Ala Leu Val Asn 
            260     


<210>  91
<211>  352
<212>  PRT
<213>  Artemisia annua

<400>  91

Met Val Ser Phe Lys His Ile Tyr Ala Thr Phe Thr Leu Leu Val Leu 
1               5                   10                  15      


Leu Ser Ser Thr Phe Cys Phe Gly Phe Pro Glu Phe Asn Phe Arg Trp 
            20                  25                  30          


Gly His Gly Arg Asp Gly Val Ser Arg Pro Ile Gly Gly Gly Arg Ser 
        35                  40                  45              


Thr Gly Leu Phe Pro Gly Phe Tyr Ser Asp Ser Cys Pro Gln Ala Asn 
    50                  55                  60                  


Asp Ile Val Met Ser Val Leu Glu Arg Ala Ile Ser Lys Asp Ser Arg 
65                  70                  75                  80  


Met Ala Ala Ser Leu Leu Arg Leu His Phe His Asp Cys Phe Val Gln 
                85                  90                  95      


Gly Cys Asp Ala Ser Val Leu Leu Asp Asp His Pro Thr Phe Val Ser 
            100                 105                 110         


Glu Lys Lys Ala Val Pro Asn Lys Asn Ser Leu Arg Gly Phe Glu Val 
        115                 120                 125             


Ile Asp Glu Ile Lys Ser Lys Leu Glu Gln Ala Cys Pro Lys Thr Val 
    130                 135                 140                 


Ser Cys Ala Asp Ile Leu Ala Leu Ser Ala Arg Gly Ser Thr Val Leu 
145                 150                 155                 160 


Ser Gly Gly Pro Asn Trp Glu Leu Pro Leu Gly Arg Arg Asp Ser Lys 
                165                 170                 175     


Lys Ala Ser Leu Asn Gly Ala Asn Lys Phe Ile Pro Pro Pro Asn Ser 
            180                 185                 190         


Thr Ile Gln Ser Leu Leu Thr Phe Phe Gln Arg Gln Gly Leu Asn Glu 
        195                 200                 205             


Val Asp Leu Val Ser Leu Ser Gly Ala His Thr Ile Gly Val Ala Arg 
    210                 215                 220                 


Cys Thr Thr Phe Lys Gln Arg Leu Tyr Asn Gln Asn Gly Asn Asn Gln 
225                 230                 235                 240 


Pro Asp Ser Thr Leu Glu Arg Ser Tyr Tyr His Asp Leu Lys Ala Val 
                245                 250                 255     


Cys Pro Lys Thr Gly Gly Asp Ser Asn Ile Ser Pro Leu Asp Tyr Thr 
            260                 265                 270         


Ser Pro Val Thr Phe Asp Asn Thr Tyr Phe Lys Leu Ile Met Ser Gly 
        275                 280                 285             


Lys Gly Leu Leu Thr Ser Asp Gln Val Leu Leu Ser Gly Asn Val Gly 
    290                 295                 300                 


Lys Thr Met Gln Leu Val Lys Ala Phe Ala Asp Asp His Thr Leu Phe 
305                 310                 315                 320 


Phe Asn His Phe Ala Arg Ser Met Val Lys Met Gly Lys Ile Ser Pro 
                325                 330                 335     


Leu Thr Gly Tyr Lys Gly Glu Val Arg Lys Asn Cys His Arg Ile Asn 
            340                 345                 350         


<210>  92
<211>  315
<212>  PRT
<213>  Artemisia annua

<400>  92

Met Val Val Leu Ala Ile Ile Phe Ser His Ala Asp Gly Gln Gly Leu 
1               5                   10                  15      


Lys Ile Gly Phe Tyr Glu Lys Ser Cys Pro His Ala Glu Lys Ile Val 
            20                  25                  30          


Phe Asn Val Met Lys Asp Val Met Ala Val Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Pro Leu Leu Arg Met His Phe His Asp Cys Phe Ile Arg Gly Cys Asp 
    50                  55                  60                  


Gly Ser Val Leu Leu Asp Ser Pro Thr Asn Gln Ser Glu Lys Phe Ser 
65                  70                  75                  80  


Ile Pro Asn Leu Ser Leu Arg Gly Tyr Asn Ile Ile Asp Arg Val Lys 
                85                  90                  95      


Thr Glu Leu Glu Lys Tyr Cys Ser Gly Val Val Ser Cys Ala Asp Ile 
            100                 105                 110         


Ser Ala Leu Val Ala Arg Asp Val Thr Val Leu Thr Lys Gly Pro Phe 
        115                 120                 125             


Trp Glu Val Glu Thr Gly Arg Arg Asp Gly Arg Ile Ser Leu Ile Gly 
    130                 135                 140                 


Asp Pro Ile Asn Pro Val Ser Gly Leu Pro Pro Phe Phe Leu Asn Ile 
145                 150                 155                 160 


Thr Ala Leu Lys Gln Ser Phe Ala Leu Arg Gly Leu Ser Val Lys Asp 
                165                 170                 175     


Leu Val Val Leu Ser Gly Gly His Thr Leu Gly Met Ser His Cys Ser 
            180                 185                 190         


Ser Phe Glu Asn Arg Leu Tyr Asn Phe Thr Gly Ile Gly Asp Thr Asp 
        195                 200                 205             


Pro Thr Met Asp Gln Asn Tyr Ile Ala Arg Leu Lys Leu Lys Cys Lys 
    210                 215                 220                 


Pro Asn Asp Gln Thr Thr Ile Ala Glu Leu Asp Pro Gly Ser Phe Lys 
225                 230                 235                 240 


Thr Phe Asp Asp Ser Tyr Phe Arg Leu Val Asn Lys Arg Arg Gly Leu 
                245                 250                 255     


Leu Gln Ser Asp Ala Ala Leu Leu Asp Asp Pro Glu Thr Lys Ala Tyr 
            260                 265                 270         


Met Ile Gln Ala Thr Ser Tyr Gly Ser Thr Phe Phe Lys Asp Phe Gly 
        275                 280                 285             


Val Ser Met Val Lys Met Gly Arg Ile Gly Val Leu Thr Gly Ser Gln 
    290                 295                 300                 


Gly Glu Ile Arg Lys Val Cys Ser Lys Val Asn 
305                 310                 315 


<210>  93
<211>  342
<212>  PRT
<213>  Artemisia annua

<400>  93

Met Gly Tyr Arg Asn Tyr Phe Ala Ile Met Phe Phe Leu Leu Phe Leu 
1               5                   10                  15      


Ser Val Thr Thr Asn Thr Pro Cys Lys Ala Gln Leu Ser Thr Lys Phe 
            20                  25                  30          


Tyr Asp Asp Thr Cys Pro Asn Ala Leu Arg Thr Ile Arg Asn Ser Ile 
        35                  40                  45              


Arg Ala Ser Ile Ser Arg Glu Arg Arg Met Ala Ala Ser Leu Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser Val Leu 
65                  70                  75                  80  


Leu Asp Asp Ala Pro Lys Ile Ile Ser Glu Lys Asn Ala Leu Pro Asn 
                85                  90                  95      


Lys Gly Ser Ala Arg Gly Phe Glu Val Ile Glu Ala Ala Lys Ala Lys 
            100                 105                 110         


Val Glu Lys Leu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Thr 
        115                 120                 125             


Val Ala Ala Arg Asp Ala Ser Glu Met Val Gly Gly Pro Ser Trp Ser 
    130                 135                 140                 


Val Lys Leu Gly Arg Arg Asp Ser Thr Thr Ala Ser Leu Val Glu Ala 
145                 150                 155                 160 


Glu Thr Ser Leu Pro Ser Phe Leu Ala Pro Leu Glu Ser Leu Ile Ser 
                165                 170                 175     


Ser Phe Lys Val Gln Gly Leu Asp Ala Arg Asp Leu Val Ala Leu Ser 
            180                 185                 190         


Gly Ala His Thr Ile Gly Gln Ala Gln Cys Val Leu Phe Arg Asp Arg 
        195                 200                 205             


Ile Tyr Asn Asn Gly Ser His Ile Asp Ala Gly Phe Ala Arg Lys Arg 
    210                 215                 220                 


Arg His His Cys Pro Lys Asn Glu Gly Asn Gly Asn Leu Ala Pro Leu 
225                 230                 235                 240 


Asp Leu Val Thr Pro Asn Ser Phe Asp Asn Asn Tyr Phe Lys Asn Leu 
                245                 250                 255     


Ile Gln Lys Lys Gly Leu Leu Glu Ser Asp Gln Val Leu Tyr Ser Gly 
            260                 265                 270         


Gly Ser Thr Asp Lys Ile Val Trp Glu Tyr Ser Arg Asn Pro Lys Lys 
        275                 280                 285             


Phe Lys Ser Asp Phe Ala Ala Ala Met Ile Lys Met Ser Glu Ile Lys 
    290                 295                 300                 


Pro Leu Thr Gly His Lys Gly Val Ile Arg Arg Ala Lys Asn Arg Lys 
305                 310                 315                 320 


Asn Ile Tyr Lys Ala Phe Phe Thr Thr Gly Ala Asn Tyr Ile Ser Glu 
                325                 330                 335     


Ser Ser Arg Val Leu Ala 
            340         


<210>  94
<211>  321
<212>  PRT
<213>  Artemisia annua

<400>  94

Met Ala Ser Tyr Asn Val Phe Ala Pro Ile Phe Phe Leu Leu Leu Ile 
1               5                   10                  15      


Leu Ile Thr Asn Asn Thr Pro Ser Glu Ala Gln Leu Ser Asn Thr Phe 
            20                  25                  30          


Tyr Asp Ser Thr Cys Pro Asn Ala Leu Arg Thr Ile Arg Thr Ser Ile 
        35                  40                  45              


Arg Thr Ala Ile Ser Arg Glu Arg Arg Met Ala Ala Ser Ile Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser Ile Leu 
65                  70                  75                  80  


Leu Asp Asp Gly Pro Thr Ile Val Ser Glu Lys Asn Ala Leu Pro Asn 
                85                  90                  95      


Lys Gly Ser Val Arg Gly Tyr Glu Val Ile Glu Ala Ala Lys Ser Glu 
            100                 105                 110         


Val Glu Lys Leu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Thr 
        115                 120                 125             


Val Ala Ala Arg Asp Ala Ser Glu Met Val Gly Gly Pro Ser Trp Ala 
    130                 135                 140                 


Val Lys Leu Gly Arg Arg Asp Ser Thr Thr Ala Ser Leu Val Leu Ala 
145                 150                 155                 160 


Asn Thr Gly Leu Pro Ser Phe Lys Ala Pro Leu Asp Ser Leu Ile Ser 
                165                 170                 175     


Thr Phe Asn Asp Asn Gly Leu Ser Pro Arg Asp Met Val Ala Leu Ser 
            180                 185                 190         


Gly Ala His Thr Ile Gly Gln Ala Gln Cys Phe Leu Phe Arg Asp Arg 
        195                 200                 205             


Ile Tyr Ala Asn Gly Ser Asp Ile Asp Ala Gly Phe Ala Ser Thr Arg 
    210                 215                 220                 


Arg Arg Arg Cys Pro Ile Asn Glu Gly Asn Glu Asn Leu Ala Ala Leu 
225                 230                 235                 240 


Asp Leu Val Thr Pro Asn Ser Phe Asp Asn Asn Tyr Phe Lys Asn Leu 
                245                 250                 255     


Ile Gln Lys Lys Gly Leu Leu Glu Ser Asp Gln Val Leu Phe Ser Gly 
            260                 265                 270         


Gly Ser Thr Asp Ser Ile Val Arg Glu Tyr Ser Asn Asn Pro Ser Lys 
        275                 280                 285             


Phe Lys Ser Asp Phe Ala Ala Ala Met Val Lys Met Ser Glu Phe Arg 
    290                 295                 300                 


Thr Ile Thr Gly Gln Glu Gly Val Ile Arg Arg Ile Cys Gly Ser Leu 
305                 310                 315                 320 


Pro 
    


<210>  95
<211>  331
<212>  PRT
<213>  Artemisia annua

<400>  95

Met Ala His Ser Leu Thr Met Thr Ile Thr Ile Met Cys Ile Ala Leu 
1               5                   10                  15      


Met Ala Leu Thr Pro Val Phe Ser Lys Ile Thr Asn Gly Gly Tyr Leu 
            20                  25                  30          


Tyr Pro Gln Phe Tyr Asp Gln Ser Cys Pro Gln Ala Thr Asn Ile Val 
        35                  40                  45              


Arg Ser Ile Val Ala Lys Asn Val Ala Lys Asp Pro Arg Met Ala Ala 
    50                  55                  60                  


Ser Leu Leu Arg Leu His Phe His Asp Cys Phe Val Lys Gly Cys Asp 
65                  70                  75                  80  


Ala Ser Val Leu Leu Asp Asn Gly Gly Pro Arg Asn Val Val Ser Glu 
                85                  90                  95      


Lys Gly Ser Val Pro Asn Asn Asn Ser Ala Arg Gly Phe Glu Val Ile 
            100                 105                 110         


Asp Glu Ile Lys Ala Ala Leu Glu Thr Ala Cys Pro Gln Thr Val Ser 
        115                 120                 125             


Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Thr Val Leu Ala 
    130                 135                 140                 


Gly Gly Pro Ser Trp Glu Val Pro Val Gly Arg Arg Asp Ser Leu Gly 
145                 150                 155                 160 


Ala Ser Leu Arg Gly Ser Asn Asn Asn Ile Pro Ala Pro Asn Asn Thr 
                165                 170                 175     


Phe Gln Thr Ile Leu Thr Lys Phe Lys Leu Arg Gly Leu Asp Ile Val 
            180                 185                 190         


Asp Leu Val Ala Leu Ser Gly Ser His Thr Ile Gly Asn Ala Arg Cys 
        195                 200                 205             


Thr Ser Phe Lys Gln Arg Leu Tyr Gly Asn Lys Gly Asn Asp Gln Ile 
    210                 215                 220                 


Asn Gln Leu Phe Ala Gln Lys Leu Arg Ala Met Cys Pro Gln Ser Gly 
225                 230                 235                 240 


Gly Asp Gln Asn Leu Ser Phe Leu Asp Asn Met Thr Pro Met Lys Phe 
                245                 250                 255     


Asp Asn Ala Tyr Tyr Lys Asn Leu Met Glu Ser Lys Gly Val Leu Ser 
            260                 265                 270         


Ser Asp Gln Ile Leu Phe Lys Asp Asn Gln Glu Thr Met Gln Leu Val 
        275                 280                 285             


Lys Glu Tyr Ala Ala Asn Glu Glu Met Phe Phe Gln Gln Phe Ala Lys 
    290                 295                 300                 


Ser Met Val Lys Met Gly Asn Ile Ser Pro Leu Thr Gly Phe Arg Gly 
305                 310                 315                 320 


Glu Ile Arg Lys Thr Cys Arg Ser Ile Asn Gly 
                325                 330     


<210>  96
<211>  322
<212>  PRT
<213>  Artemisia annua

<400>  96

Met Thr Ser Ser Ser Ser Ser Tyr Leu Ser Ser Leu Pro Thr Cys Ile 
1               5                   10                  15      


Leu Cys Leu Cys Val Leu Ala Arg Met Ala Ser Gly Gln Leu Thr Ala 
            20                  25                  30          


Asn Phe Tyr Ala Ser Ser Cys Pro Asn Phe Ser Thr Thr Ile Ser Thr 
        35                  40                  45              


Ala Val Asn Ser Ala Val Ser Asn Glu Ala Arg Met Gly Ala Ser Leu 
    50                  55                  60                  


Leu Arg Leu His Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Val Leu Leu Asp Asp Thr Ala Asn Phe Thr Gly Glu Lys Thr Ala Ala 
                85                  90                  95      


Pro Asn Asn Asn Ser Leu Arg Gly Phe Asp Val Ile Asp Thr Ile Lys 
            100                 105                 110         


Thr Gln Leu Glu Ser Ser Cys Pro Gly Val Val Ser Cys Ala Asp Ile 
        115                 120                 125             


Leu Ala Thr Ala Ala Arg Asp Ser Val Val Ala Leu Gly Gly Pro Ser 
    130                 135                 140                 


Trp Asn Leu Val Phe Gly Arg Arg Asp Ser Thr Thr Ala Ser Leu Ser 
145                 150                 155                 160 


Ala Ala Asn Asn Asn Ile Pro Ala Pro Thr Leu Asn Leu Ser Gly Leu 
                165                 170                 175     


Ile Ser Ser Phe Ser Asn Gln Asn Phe Thr Thr Asn Glu Met Val Ala 
            180                 185                 190         


Leu Ser Gly Ser His Thr Ile Gly Gln Ala Arg Cys Thr Val Phe Arg 
        195                 200                 205             


Ala Arg Ile Tyr Asn Glu Asn Asn Ile Asn Ser Ser Phe Ala Thr Ser 
    210                 215                 220                 


Val Arg Ala Asn Cys Pro Ser Ser Gly Gly Asp Asn Asn Leu Ser Pro 
225                 230                 235                 240 


Leu Asp Val Val Ser Pro Thr Ser Phe Asp Asn Ser Tyr Phe Ser Asn 
                245                 250                 255     


Leu Leu Asn Gln Asn Gly Leu Leu His Ser Asp Gln Glu Leu Phe Asn 
            260                 265                 270         


Gly Gly Thr Thr Asp Ala Gln Val Arg Thr Tyr Ser Ser Asn Ser Ala 
        275                 280                 285             


Thr Phe Ser Thr Asp Phe Ala Asn Ala Met Val Lys Met Ser Asn Leu 
    290                 295                 300                 


Asn Pro Leu Thr Gly Ser Ser Gly Glu Val Arg Thr Asn Cys Arg Arg 
305                 310                 315                 320 


Thr Asn 
        


<210>  97
<211>  321
<212>  PRT
<213>  Artemisia annua

<400>  97

Met Asn Ile Ile Ser Phe Leu Ser Phe Phe Val Phe Leu Met Leu Ser 
1               5                   10                  15      


Ile Ala Thr Ala Ser Ser Asp Asp Tyr Gly Leu Ser Thr Lys Tyr Tyr 
            20                  25                  30          


Asp Arg Val Cys Pro Gln Ala Leu Pro Thr Ile Lys Arg Val Val Glu 
        35                  40                  45              


Asp Ala Val Ala Gln Glu Arg Arg Met Gly Ala Ser Leu Leu Arg Leu 
    50                  55                  60                  


His Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu Leu 
65                  70                  75                  80  


Asp Gln Thr Ser Thr Ile Asp Thr Glu Lys Asn Ala Ile Ala Asn Thr 
                85                  90                  95      


Asn Ser Ala Arg Gly Phe Glu Val Ile Asp Lys Ile Lys Ser Glu Val 
            100                 105                 110         


Asp Lys Ile Cys Gly Arg Pro Ile Val Ser Cys Ala Asp Ile Leu Thr 
        115                 120                 125             


Val Val Ala Arg Asp Ser Val Val Ala Leu Gly Gly Pro Thr Trp Asp 
    130                 135                 140                 


Val Lys Leu Gly Arg Arg Asp Ser Thr Thr Ala Ser Gln Val Thr Ala 
145                 150                 155                 160 


Asn Val Thr Ile Pro Ser Pro Phe Met Asp Leu Pro Ala Leu Ile Lys 
                165                 170                 175     


Ser Phe Glu Asp Gln Gly Leu Asp Glu Glu Asp Leu Val Val Leu Ser 
            180                 185                 190         


Gly Ala His Thr Leu Gly Phe Ala Gln Cys Arg Thr Phe Arg Arg His 
        195                 200                 205             


Ile Tyr Asn Asp Ser Asn Ile Asp Pro Ala Phe Ala Gly Gln Leu Arg 
    210                 215                 220                 


Thr Asn Cys Pro Gln Val Gly Gly Asp Ser Asn Leu Val Pro Leu Asp 
225                 230                 235                 240 


Pro Thr Pro Ser Ser Phe Asp Asn Arg Tyr Phe Asn Asn Leu Val Ser 
                245                 250                 255     


Lys Arg Gly Val Leu Gly Ser Asp Gln Ala Leu Phe Asn Gly Gly Glu 
            260                 265                 270         


Thr Asp Glu Leu Val Ser Lys Tyr Asn Glu Asn Tyr Glu Glu Phe Phe 
        275                 280                 285             


Lys Asp Phe Ala Lys Ser Met Ile Lys Met Gly Asn Ile Asn Leu Leu 
    290                 295                 300                 


Thr Gly Asn Arg Gly Gln Ile Arg Asp Asn Cys Arg Arg Ile Asn Ser 
305                 310                 315                 320 


Gln 
    


<210>  98
<211>  361
<212>  PRT
<213>  Artemisia annua

<400>  98

Met Ala Phe Leu Ile Tyr Asn Thr Cys Met Leu Met Val Leu Leu Ser 
1               5                   10                  15      


Ser Ser Val Thr Ser Phe Ala Phe Pro Gly Phe Ser Phe Gly Trp Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Gly Asp Gly Ser Phe Gly Gly Gly Asp Gly Ser 
        35                  40                  45              


Phe Gly Gly Val Leu Gly Tyr Ser Gly Leu Phe Pro Glu Phe Tyr Ser 
    50                  55                  60                  


Phe Ser Cys Pro Gln Ala Asn Asp Ile Val Met Ser Val Leu Glu Asp 
65                  70                  75                  80  


Val Ile Ala Lys Asp Pro Arg Met Ala Ala Ser Leu Leu Arg Leu His 
                85                  90                  95      


Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser Val Leu Leu Asp 
            100                 105                 110         


Asp Ser Ala Met Phe Thr Ser Glu Lys Asn Ala Gly Pro Asn Ala Asn 
        115                 120                 125             


Ser Ile Arg Gly Phe Glu Val Ile Asp Glu Ile Lys Ser Lys Leu Glu 
    130                 135                 140                 


Glu Ala Cys Pro Glu Thr Val Ser Cys Ala Asp Ile Leu Ala Leu Ala 
145                 150                 155                 160 


Ala Arg Gly Ser Thr Val Leu Ser Gly Gly Pro Asn Trp Glu Leu Pro 
                165                 170                 175     


Leu Gly Arg Arg Asp Ala Thr Gln Ala Asn Phe Lys Glu Ser Asn Asn 
            180                 185                 190         


Asn Leu Pro Pro Pro Asn Ser Thr Ile Gln Asn Leu Ile Thr Leu Phe 
        195                 200                 205             


Arg Arg Gln Gly Leu Asp Glu Val Asp Leu Val Ser Leu Ser Gly Ala 
    210                 215                 220                 


His Thr Ile Gly Met Ala Arg Cys Thr Ser Phe Lys Gln Arg Leu Tyr 
225                 230                 235                 240 


Asn Gln Asp Gly Asn Asn Gln Pro Asp Ser Thr Leu Glu Arg Thr Tyr 
                245                 250                 255     


Ser Asn Gly Leu Lys Glu Ile Cys Pro Lys Thr Gly Gly Asp Ser Asn 
            260                 265                 270         


Ile Ser Pro Leu Asp Phe Ser Ser Pro Ala Arg Phe Asp Asn Thr Tyr 
        275                 280                 285             


Phe Lys Leu Ile Met Trp Gly Lys Gly Leu Leu Thr Ser Asp Gln Val 
    290                 295                 300                 


Leu Leu Asn Gly Asn Val Glu Glu Thr Met Phe Leu Val Lys Ala Phe 
305                 310                 315                 320 


Ala Glu Asp Asp Ser Leu Phe Tyr Asp Gln Phe Ala Arg Ser Met Val 
                325                 330                 335     


Lys Met Gly Asn Ile Asn Pro Leu Thr Gly Phe Asn Gly Glu Ile Arg 
            340                 345                 350         


Lys Asn Cys Arg Met Val Asn Gln Leu 
        355                 360     


<210>  99
<211>  359
<212>  PRT
<213>  Artemisia annua

<400>  99

Met Phe Tyr Thr Val Tyr Glu Asp Tyr Asn Ile Asp Gln Val Leu His 
1               5                   10                  15      


Val Val Arg Leu Arg Val Ser Phe His Tyr Ala Glu Ile Met Ile Ile 
            20                  25                  30          


Ser Thr Tyr Asn Lys Lys Met Asn Ile Ile Arg Phe Leu Ser Phe Phe 
        35                  40                  45              


Val Phe Leu Met Leu Ser Ile Ala Thr Ala Ser Ser Asp Asp Tyr Gly 
    50                  55                  60                  


Leu Ser Thr Lys Tyr Tyr Asp Arg Val Cys Pro Gln Ala Leu Pro Thr 
65                  70                  75                  80  


Ile Lys Arg Val Val Glu Asp Ala Val Ala Gln Glu Arg Arg Met Gly 
                85                  90                  95      


Ala Ser Leu Leu Arg Leu His Phe His Asp Cys Phe Val Asn Gly Cys 
            100                 105                 110         


Asp Ala Ser Ile Leu Leu Asp Gln Thr Ser Thr Ile Asp Thr Glu Lys 
        115                 120                 125             


Asn Ala Val Ala Asn Val Asp Ser Ala Arg Gly Phe Asp Val Ile Asp 
    130                 135                 140                 


Lys Ile Lys Ser Glu Val Asp Lys Ile Cys Gly His Pro Val Val Ser 
145                 150                 155                 160 


Cys Ala Asp Ile Leu Thr Val Ala Ala Arg Asp Ser Val Val Ala Leu 
                165                 170                 175     


Gly Gly Pro Thr Trp Asp Val Lys Leu Gly Arg Arg Asp Ser Thr Thr 
            180                 185                 190         


Ala Ser Gln Ala Thr Ala Asn Val Thr Ile Pro Ser Pro Phe Met Asp 
        195                 200                 205             


Leu Pro Ala Leu Ile Lys Ser Phe Glu Asp Gln Gly Leu Asp Glu Glu 
    210                 215                 220                 


Asp Leu Val Val Leu Ser Gly Ala His Thr Leu Gly Phe Ala Gln Cys 
225                 230                 235                 240 


Arg Thr Phe Arg Pro His Ile Tyr Asn Asp Asn Asn Ile Asp Pro Ala 
                245                 250                 255     


Phe Ala Ser Gln Leu Arg Asn Asn Cys Pro Gln Val Gly Gly Asp Ser 
            260                 265                 270         


Asn Leu Ala Pro Leu Asp Pro Thr Pro Ser Ser Phe Asp Thr Arg Tyr 
        275                 280                 285             


Phe Asn Asn Leu Val Ser Lys Arg Gly Val Leu Arg Ser Asp Gln Ala 
    290                 295                 300                 


Leu Phe Asn Gly Gly Glu Thr Asp Glu Leu Val Ser Lys Tyr Asn Glu 
305                 310                 315                 320 


Asn Tyr Glu Lys Phe Phe Lys Asp Phe Ala Lys Ser Met Ile Lys Met 
                325                 330                 335     


Gly Asn Ile Asn Leu Leu Thr Gly Asn Arg Gly Gln Ile Arg Asp Asn 
            340                 345                 350         


Cys Arg Arg Ile Asn Ser Gln 
        355                 


<210>  100
<211>  333
<212>  PRT
<213>  Artemisia annua

<400>  100

Met Glu Ile Lys Ser Thr Ile Phe Ile Phe Ser Leu Ile Thr Leu Cys 
1               5                   10                  15      


Cys Leu Thr Phe Ser His Ala Ala Asp Pro Pro Leu Thr Leu Asp Tyr 
            20                  25                  30          


Tyr Lys Ser Thr Cys Pro Asn Ala Glu Ala Ile Val Arg Lys Glu Met 
        35                  40                  45              


Glu Cys Ala Val Thr Ser Asp Leu Arg Asn Ala Ala Ala Ile Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Gly Ser Val Leu 
65                  70                  75                  80  


Leu Asp Asp Thr Tyr Met Leu Lys Gly Glu Lys Asn Ala Pro Thr Asn 
                85                  90                  95      


Leu Asn Ala Leu Lys Gly Phe Asp Ile Ile Asp Arg Ile Lys Asn Lys 
            100                 105                 110         


Leu Glu Ser Glu Cys Pro Gly Thr Val Ser Cys Ala Asp Val Leu Thr 
        115                 120                 125             


Tyr Ala Ala Arg Asp Ala Thr Val Leu Val Gly Gly Pro Tyr Trp His 
    130                 135                 140                 


Val Pro Ala Gly Arg Lys Asp Ser Lys Thr Ala Ser Ala Ser Leu Val 
145                 150                 155                 160 


Glu Ser Asn Ile Pro Gly Ala Asn Asn Gly Leu Leu Thr Met Ile Ser 
                165                 170                 175     


Lys Phe Met Tyr Gln Ser Leu Ser Val Thr Asp Met Val Ala Leu Ser 
            180                 185                 190         


Gly Ala His Thr Ile Gly Met Ala Arg Cys Thr Asn Tyr Arg Ala Arg 
        195                 200                 205             


Ile Tyr Gly Asp Tyr Gln Arg Thr Ala Thr Met Ser Ser Ile Ala Asp 
    210                 215                 220                 


Ser Asn Leu Lys Thr Leu Lys Ser Thr Cys Pro Ala Ala Gly Gly Gly 
225                 230                 235                 240 


Asp Asn Asn Glu Ser Ala Met Asp Tyr Ile Ser Pro Asn Leu Phe Asp 
                245                 250                 255     


Asn Ser Tyr Tyr His Ile Leu Leu Arg Gly Glu Gly Leu Leu Ala Ser 
            260                 265                 270         


Asp Gln Glu Leu Tyr Ser Ser Met Leu Gly Val Gln Thr Ser Asn Leu 
        275                 280                 285             


Val Lys Lys Tyr Ala Glu Asn Gln Leu Ala Phe Phe Glu Gln Phe Ser 
    290                 295                 300                 


Glu Ser Met Val Lys Leu Gly Asn Ile Thr Asn Pro Glu Thr Tyr Val 
305                 310                 315                 320 


Asp Gly Glu Val Arg Lys Asn Cys Arg Phe Val Asn Thr 
                325                 330             


<210>  101
<211>  333
<212>  PRT
<213>  Artemisia annua

<400>  101

Met Ala Cys Phe Lys Asn Leu Phe Gly Ile Leu Met Leu Gln Met Val 
1               5                   10                  15      


Val Leu Ala Ile Ile Ser Ser His Ala Asp Gly Gln Gly Leu Lys Ile 
            20                  25                  30          


Gly Phe Tyr Glu Lys Ser Cys Pro Gln Ala Glu Lys Ile Val Phe Asn 
        35                  40                  45              


Val Met Lys Asp Val Met Ala Val Ala Pro Ser Leu Ser Gly Pro Leu 
    50                  55                  60                  


Leu Arg Met His Phe His Asp Cys Phe Ile Arg Gly Cys Asp Gly Ser 
65                  70                  75                  80  


Val Leu Leu Asp Ser Pro Asn Asn Gln Ser Glu Lys Phe Ser Ile Pro 
                85                  90                  95      


Asn Leu Ser Leu Arg Gly Tyr Asn Ile Ile Asp Arg Val Lys Thr Glu 
            100                 105                 110         


Leu Glu Lys Tyr Cys Pro Gly Val Val Ser Cys Ala Asp Ile Ser Ala 
        115                 120                 125             


Leu Val Ala Arg Asp Val Thr Val Leu Thr Lys Gly Pro Phe Trp Asp 
    130                 135                 140                 


Val Glu Thr Gly Arg Arg Asp Gly Lys Ile Ser Leu Ile Gly Asp Pro 
145                 150                 155                 160 


Ile Asn Pro Val Ser Gly Leu Pro Pro Phe Phe Leu Asn Ile Thr Ala 
                165                 170                 175     


Leu Lys Gln Ser Phe Ala Leu Arg Gly Leu Ser Val Lys Asp Leu Val 
            180                 185                 190         


Val Leu Ser Gly Gly His Thr Leu Gly Met Ser His Cys Ser Ser Phe 
        195                 200                 205             


Glu Asn Arg Leu Tyr Asn Phe Thr Gly Ile Gly Asp Thr Asp Pro Thr 
    210                 215                 220                 


Met Asp Arg Asn Tyr Ile Ala Arg Leu Lys Leu Lys Cys Lys Pro Asn 
225                 230                 235                 240 


Asp Gln Thr Thr Ile Ala Glu Leu Asp Pro Gly Ser Phe Lys Thr Phe 
                245                 250                 255     


Asp Asp Ser Tyr Phe Arg Leu Val Asn Lys Arg Arg Gly Leu Leu Gln 
            260                 265                 270         


Ser Asp Ala Ala Leu Leu Asp Asp Pro Glu Thr Lys Ala Tyr Met Ile 
        275                 280                 285             


Gln Ala Thr Ser Tyr Gly Ser Thr Phe Phe Lys Asp Phe Gly Val Ser 
    290                 295                 300                 


Met Ile Lys Met Gly Arg Ile Gly Val Leu Thr Gly Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Arg Lys Val Cys Ser Lys Val Asn Glu Ser Pro Asn 
                325                 330             


<210>  102
<211>  512
<212>  PRT
<213>  Artemisia annua

<400>  102

Met Glu Ile Tyr Ser His Ile Arg Thr Pro Ile Leu Tyr Val Val Leu 
1               5                   10                  15      


Leu Ala Ala Met Ser Thr Leu Ala Leu Ser Cys Thr Gln Val Gly Phe 
            20                  25                  30          


Tyr Lys Thr Thr Cys Pro Pro Ala Glu Gly Ile Val Lys Ser Val Val 
        35                  40                  45              


Gln Ser Ala Ile Arg Ser Asn Leu Thr Ile Ala Pro Gly Leu Leu Arg 
    50                  55                  60                  


Met Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu 
65                  70                  75                  80  


Ile Asp Gly Leu Ser Ala Glu Lys Ile Val Val Gln Asn Leu Ala Leu 
                85                  90                  95      


Arg Gly Phe Glu Val Ile Gln Ala Ala Lys Ser Lys Leu Glu Thr Val 
            100                 105                 110         


Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg 
        115                 120                 125             


Asp Ser Val Val Gln Ser Gly Gly Met Asn Trp Glu Val Pro Thr Gly 
    130                 135                 140                 


Arg Arg Asp Gly Leu Val Ser Arg Asp Thr Asp Ala Lys Lys Leu Pro 
145                 150                 155                 160 


Gly Ser Thr Asp Asn Val Thr Ser Gln Ile Lys Lys Phe Ala Asp Lys 
                165                 170                 175     


Gly Leu Ser Ile Gln Asp Leu Val Thr Leu Val Gly Gly His Thr Ile 
            180                 185                 190         


Gly Thr Ala Ala Cys Gly Arg Phe Asp Tyr Arg Leu Tyr Asn Tyr Asn 
        195                 200                 205             


Asn Thr Asn Lys Pro Asp Pro Asp Ile Asp Gln Glu Phe Leu Ala Lys 
    210                 215                 220                 


Leu Lys Thr His Cys Pro Cys Lys Ser Asn Asn Thr Asn Arg Val Pro 
225                 230                 235                 240 


Leu Asp Thr Asn Ser Glu Thr Asn Phe Asp Asn Ser Tyr Tyr Gly Asn 
                245                 250                 255     


Val Arg Asn Gly Gln Gly Val Leu Glu Ser Asp Ser Lys Leu Trp Ser 
            260                 265                 270         


Asp Gly Arg Thr His Lys Phe Val Gln Gln Phe Leu Gly Ser Ser Asn 
        275                 280                 285             


Arg Leu Lys Phe Lys Lys Gln Phe Gly Arg Ala Met Val Lys Leu Ser 
    290                 295                 300                 


Asn Val Glu Val Lys Thr Gly Asn Gln Gly Glu Ile Arg Arg Ser Gly 
305                 310                 315                 320 


Gly Met Thr Trp Glu Val Pro Thr Gly Arg Arg Asp Gly Leu Val Ser 
                325                 330                 335     


Arg Asp Thr Asp Ala Lys Lys Leu Pro Gly Ser Thr Asp Asn Val Thr 
            340                 345                 350         


Ser Gln Ile Lys Lys Phe Ala Asp Lys Gly Leu Ser Ile Gln Asp Leu 
        355                 360                 365             


Val Thr Leu Val Gly Gly His Thr Ile Gly Thr Ala Ala Cys Gly Arg 
    370                 375                 380                 


Phe Asp Tyr Arg Leu Tyr Asn Tyr Asn Asn Thr Asn Lys Pro Asp Pro 
385                 390                 395                 400 


Asp Ile Asp Gln Glu Phe Leu Ala Lys Leu Lys Thr His Cys Pro Cys 
                405                 410                 415     


Lys Ser Asn Asn Thr Asn Arg Val Pro Leu Asp Thr Asn Ser Glu Thr 
            420                 425                 430         


Asn Phe Asp Asn Ser Tyr Tyr Gly Asn Val Arg Asn Gly Arg Gly Val 
        435                 440                 445             


Leu Glu Ser Asp Ser Lys Leu Trp Ser Asp Gly Arg Thr His Lys Phe 
    450                 455                 460                 


Val Gln Gln Phe Leu Gly Ser Ser Asn Arg Leu Lys Phe Lys Lys Gln 
465                 470                 475                 480 


Phe Gly Arg Ala Met Val Lys Leu Ser Asn Val Glu Val Lys Thr Gly 
                485                 490                 495     


Asn Gln Gly Glu Ile Arg Arg Gly Tyr Asn Ile Ser Lys Gln Lys Phe 
            500                 505                 510         


<210>  103
<211>  337
<212>  PRT
<213>  Artemisia annua

<400>  103

Met Lys Ile Thr Leu Leu Ser Leu Val Ser Ile Leu Phe Phe Leu Ser 
1               5                   10                  15      


Val Ser Ala Ser Ser Asn Pro Ser Leu Leu His Ser Leu Lys Val Pro 
            20                  25                  30          


Ser Leu Thr Asp Thr Thr His Phe Glu Asp Glu Leu Ser Tyr Ser Leu 
        35                  40                  45              


Tyr Arg His Ser Cys Ser His Ala Glu Gly Ile Ile Tyr Arg Lys Val 
    50                  55                  60                  


Arg Asp Trp Val Lys Lys Asp Pro Thr Ile Gly Pro Ser Leu Ile Arg 
65                  70                  75                  80  


Leu His Phe His Asp Cys Ala Val Arg Gly Cys Asp Ala Ser Ile Leu 
                85                  90                  95      


Leu Asp His Ser Gly Ser Glu Lys Ser Ala Asn Val Ser Lys Ser Leu 
            100                 105                 110         


Arg Gly Phe Glu Leu Ile Asn Glu Ile Lys Ala Glu Leu Glu Lys Lys 
        115                 120                 125             


Cys Pro Lys Thr Val Ser Cys Ala Asp Ile Leu Thr Thr Ala Ala Arg 
    130                 135                 140                 


Asp Ala Thr Val Leu Ala Gly Gly Pro Phe Trp Met Ile Pro Phe Gly 
145                 150                 155                 160 


Arg Lys Asp Gly Arg Val Ser Leu Ala Lys Glu Ala Thr Ala Val Pro 
                165                 170                 175     


Met Gly Arg Glu Ser Ile Thr Gln Leu Ile Glu Phe Phe Gln Ser Lys 
            180                 185                 190         


Gly Leu Asn Val Leu Asp Leu Val Val Leu Ser Gly Ala His Thr Ile 
        195                 200                 205             


Gly Arg Thr Thr Cys Glu Ser Val Gln His Arg Leu Tyr Asn Tyr Lys 
    210                 215                 220                 


Gly Thr Lys Lys Pro Asp Pro Ser Ile Asp Pro Gln Tyr Leu Asn Tyr 
225                 230                 235                 240 


Leu Arg Arg Lys Cys Arg Trp Ala Ser Glu Asn Val Tyr Leu Asp Ala 
                245                 250                 255     


Thr Thr Pro Lys Thr Phe Asp Val Gln Tyr Tyr Gln Asn Leu Lys Lys 
            260                 265                 270         


Lys Met Gly Leu Leu Ser Thr Asp Gln Leu Leu Tyr Ser Asp Ser Arg 
        275                 280                 285             


Thr Lys Pro Ile Ala Asp Ala Leu Ser Phe Glu Ser Ser Leu Phe Ser 
    290                 295                 300                 


Asn Gln Phe Ser Val Ser Met Val Lys Leu Ala Asn Ile Leu Asp Tyr 
305                 310                 315                 320 


Lys Ser Gln Asp Tyr Gly Glu Ile Arg Thr Arg Cys Asn Arg Val Asn 
                325                 330                 335     


Lys 
    


<210>  104
<211>  343
<212>  PRT
<213>  Artemisia annua

<400>  104

Met Glu Thr Thr Met Ile Asn Ile Phe Val Leu Leu Val Ala Ser Ile 
1               5                   10                  15      


Leu Val Ala Gly Gly Met Ala Ser His Gly Asn Gly Ile Ala Arg Gly 
            20                  25                  30          


Arg Gly His Gly Gly Gly Gly Gly Leu Lys Met Arg Tyr Tyr Ala Lys 
        35                  40                  45              


Arg Cys Gly Ser Val Ser Val Glu Asn Thr Val Arg Gly Ile Val Trp 
    50                  55                  60                  


Asn Lys Val Ala Ala Asp Pro Ser Leu Ala Gly Lys Leu Leu Arg Leu 
65                  70                  75                  80  


His Asn His Asp Cys Phe Val Arg Gly Cys Asp Gly Ser Ile Leu Leu 
                85                  90                  95      


Asp Pro Thr Gln Asn Met Thr Thr Glu Lys Thr Ala Gly Pro Asn Arg 
            100                 105                 110         


Ser Val Ser Gly Phe Glu Leu Ile Asp Glu Ile Lys Thr Lys Leu Glu 
        115                 120                 125             


Ala Asn Cys Pro Gly Ile Val Ser Cys Ala Asp Ile Val Ala Leu Ala 
    130                 135                 140                 


Ala Arg Asp Ala Val Ser Phe Gln Phe Arg Arg Asp Ala Trp Pro Val 
145                 150                 155                 160 


Phe Thr Gly Arg Lys Asp Gly Arg Val Ser Leu Ala Ser Glu Val Gly 
                165                 170                 175     


Asp Asn Leu Pro Ser Ala Asn Ala Asp Phe Thr Thr Leu Leu Ser Gln 
            180                 185                 190         


Phe Glu Ser Lys Gly Leu Asn Leu Asn Asp Leu Val Thr Leu Ser Gly 
        195                 200                 205             


Ala His Thr Ile Gly Met Ser Arg Cys Ala Leu Val Ala Arg Arg Leu 
    210                 215                 220                 


Tyr Asn Phe Thr Gly Val Gly Asp Ala Asp Pro Ser Leu Asp Ala Thr 
225                 230                 235                 240 


Tyr Ala Gln Lys Leu Arg Asn Leu Cys Pro Lys Pro Ile Thr Pro Ser 
                245                 250                 255     


Thr Pro Leu Glu Met Asp Pro Lys Ser Ser Leu Ser Phe Asp Ser Asn 
            260                 265                 270         


Tyr Tyr Arg Ile Leu Asn Gln His Lys Gly Leu Phe Val Ser Asp Ala 
        275                 280                 285             


Ala Leu Leu Thr Asn Arg Thr Ser Ala Lys Ile Thr Lys Val Leu Glu 
    290                 295                 300                 


Asn Pro Lys Val Phe Phe Asp Gln Phe Ala Gln Ser Met Val His Met 
305                 310                 315                 320 


Gly Ala Ile Glu Val Leu Thr Asn Gly Gln Gly Glu Val Arg Arg Asn 
                325                 330                 335     


Cys Arg Val Val Asn Gly His 
            340             


<210>  105
<211>  301
<212>  PRT
<213>  Artemisia annua

<400>  105

Met Arg Tyr Tyr Glu Lys Arg Cys Gly Ser Val Ser Val Glu Asn Ser 
1               5                   10                  15      


Val Arg Glu Ile Val Trp Asn Lys Val Ala Ala Asp Pro Ser Leu Ala 
            20                  25                  30          


Ala Lys Leu Leu Arg Leu His Tyr His Asp Cys Phe Val Arg Gly Cys 
        35                  40                  45              


Asp Gly Ser Ile Leu Leu Asp Pro Thr Gln Asn Thr Thr Thr Glu Lys 
    50                  55                  60                  


Thr Ala Gly Pro Asn Arg Ser Ile Ser Gly Tyr Glu Val Ile Asp Glu 
65                  70                  75                  80  


Ile Lys Thr Lys Leu Glu Ala Asp Cys Pro Gly Ile Val Ser Cys Ala 
                85                  90                  95      


Asp Ile Val Ala Leu Ala Ala Arg Asp Ala Val Ser Phe Gln Phe Arg 
            100                 105                 110         


Arg Asp Ala Trp Pro Val Phe Thr Gly Arg Lys Asp Gly Arg Val Ser 
        115                 120                 125             


Arg Asp Ser Glu Val Gly Gly Asn Leu Pro Ser Ala Asn Ala Asn Phe 
    130                 135                 140                 


Thr Thr Leu Leu Ser Gln Phe Gly Ser Lys Gly Leu Asn Leu Ile Asp 
145                 150                 155                 160 


Leu Val Thr Leu Ser Gly Ala His Thr Ile Gly Met Ser Arg Cys Ala 
                165                 170                 175     


Leu Val Ala Arg Arg Leu Tyr Asn Phe Thr Gly Val Gly Asp Ala Asp 
            180                 185                 190         


Pro Ser Leu Asp Ala Thr Tyr Ala Gln Thr Leu Arg Asn Leu Cys Pro 
        195                 200                 205             


Asn Pro Val Asn Pro Ser Thr Pro Leu Glu Met Asp Pro Lys Ser Ser 
    210                 215                 220                 


Phe Thr Phe Asp Ser Asn Tyr Tyr Arg Ile Leu Asn Gln His Lys Gly 
225                 230                 235                 240 


Leu Phe Val Ser Asp Ala Ala Leu Leu Thr Asn Arg Gln Ser Ala Lys 
                245                 250                 255     


Ile Thr Lys Val Leu Glu Asn Pro Lys Val Phe Phe Asp Gln Phe Ala 
            260                 265                 270         


Gln Ser Met Val His Met Gly Ala Ile Glu Val Leu Thr Asn Gly Gln 
        275                 280                 285             


Gly Glu Val Arg Arg Asn Cys Arg Val Val Asn Gly His 
    290                 295                 300     


<210>  106
<211>  311
<212>  PRT
<213>  Artemisia annua

<400>  106

Met Thr Leu Lys Val Pro Ser Leu Ala Asp Leu Ser Ser Leu Glu Asp 
1               5                   10                  15      


Asp Leu Ser Tyr Ser Leu Tyr Arg Glu Ser Cys Tyr Asp Leu Glu Gly 
            20                  25                  30          


Ile Ile Tyr Arg Lys Val Lys Glu Trp Val Thr Lys Asp Pro Thr Leu 
        35                  40                  45              


Ala Pro Ser Leu Leu Arg Leu Gln Tyr His Asp Cys Val Val Arg Gly 
    50                  55                  60                  


Cys Asp Ala Ser Ile Leu Leu Asp His Glu Gly Ser Glu Lys Thr Ser 
65                  70                  75                  80  


Asn Met Ser Lys Ser Leu Arg Gly Phe Glu Val Ile Asp Asp Ile Lys 
                85                  90                  95      


Ala Glu Ile Glu Lys Lys Cys Pro Lys Thr Val Ser Cys Ala Asp Ile 
            100                 105                 110         


Leu Thr Thr Val Ala Arg Asp Ala Thr Val Leu Ala Gly Gly Pro Tyr 
        115                 120                 125             


Trp Met Ile Pro Tyr Gly Arg Lys Asp Gly Arg Val Ser Leu Ala Lys 
    130                 135                 140                 


Glu Ala Ser Ile Val Pro Lys Gly Ser Glu Ser Val Thr Asn Leu Ile 
145                 150                 155                 160 


Glu Phe Phe Gln Ser Lys Gly Leu Asn Val Leu Asp Leu Val Ile Leu 
                165                 170                 175     


Ser Gly Ala His Thr Ile Gly Lys Thr Thr Cys Glu Ser Val Gln His 
            180                 185                 190         


Arg Leu Tyr Asp Tyr Lys Gly Thr Lys Lys Pro Asp Pro Ser Leu Asp 
        195                 200                 205             


Pro Lys Tyr Leu Asn Tyr Leu Arg Arg Lys Cys Arg Trp Ala Ser Glu 
    210                 215                 220                 


Asn Val Asn Leu Asp Gly Glu Thr Pro Asn Thr Phe Asp Thr Gln Tyr 
225                 230                 235                 240 


Tyr His Asn Leu Lys Lys Asn Met Gly Leu Leu Ser Thr Asp Gln Met 
                245                 250                 255     


Leu Tyr Ser Asp Ser Arg Thr Lys Pro Ile Ala Asp Gly Leu Ser Phe 
            260                 265                 270         


Gln Ser Ser Leu Phe Lys Asn Gln Phe Gly Val Ala Met Val Lys Leu 
        275                 280                 285             


Ser Ser Ile Leu Asp Val Val Ser Gln Asp Glu Gly Glu Ile Arg Thr 
    290                 295                 300                 


Asp Cys Lys Tyr Val Asn His 
305                 310     


<210>  107
<211>  647
<212>  PRT
<213>  Artemisia annua

<400>  107

Met Ala Gly Ser Lys Asn Phe Phe Gly Ile Leu Met Leu Gln Met Val 
1               5                   10                  15      


Val Leu Ala Ile Ile Phe Ser His Ala Asp Gly Gln Gly Leu Lys Ile 
            20                  25                  30          


Gly Phe Tyr Glu Lys Ser Cys Pro His Ala Glu Lys Ile Val Phe Asn 
        35                  40                  45              


Val Met Lys Asp Val Met Ala Val Ala Pro Ser Leu Ser Gly Pro Leu 
    50                  55                  60                  


Leu Arg Met His Phe His Asp Cys Phe Ile Arg Gly Cys Asp Gly Ser 
65                  70                  75                  80  


Val Leu Leu Asp Ser Pro Thr Asn Gln Ser Glu Lys Phe Ser Ile Pro 
                85                  90                  95      


Asn Leu Ser Leu Arg Gly Tyr Asn Ile Ile Asp Arg Val Lys Thr Glu 
            100                 105                 110         


Leu Glu Lys Tyr Cys Pro Gly Val Val Ser Cys Ala Asp Ile Ser Ala 
        115                 120                 125             


Leu Val Ala Arg Asp Val Thr Val Leu Thr Lys Gly Pro Phe Trp Glu 
    130                 135                 140                 


Val Glu Thr Gly Arg Arg Asp Gly Arg Ile Ser Leu Ile Gly Asp Pro 
145                 150                 155                 160 


Ile Asn Pro Val Ser Gly Leu Pro Pro Phe Phe Leu Asn Ile Thr Ala 
                165                 170                 175     


Leu Lys Gln Ser Phe Ala Leu Arg Gly Leu Ser Val Lys Asp Leu Val 
            180                 185                 190         


Val Leu Ser Gly Gly His Thr Leu Gly Met Ser His Cys Ser Ser Phe 
        195                 200                 205             


Glu Asn Arg Leu Tyr Asn Phe Thr Gly Ile Gly Asp Thr Asp Pro Thr 
    210                 215                 220                 


Met Asp Gln Asn Tyr Ile Thr Arg Leu Lys Leu Lys Cys Lys Pro Asn 
225                 230                 235                 240 


Asp Gln Thr Thr Ile Ala Glu Leu Asp Pro Gly Ser Phe Lys Thr Phe 
                245                 250                 255     


Asp Asp Ser Tyr Phe Arg Leu Val Asn Lys Arg Arg Gly Leu Leu Gln 
            260                 265                 270         


Ser Asp Ala Ala Leu Leu Asp Asp Pro Glu Thr Lys Ala Tyr Met Ile 
        275                 280                 285             


Gln Ala Thr Ser Tyr Gly Ser Thr Phe Phe Lys Asp Phe Gly Val Ser 
    290                 295                 300                 


Met Val Lys Met Gly Arg Ile Gly Val Leu Thr Gly Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Arg Lys Val Cys Ser Lys Glu Val Val Ser Asp Leu Lys Ser Val 
                325                 330                 335     


Arg Cys Leu Met Lys Cys Leu Lys Gly Ile Phe Ser Ser Thr Ile Ile 
            340                 345                 350         


Ser Asn Ser Ser Trp Leu Cys Ala Lys Asp Thr Ser Phe Asp Cys Gln 
        355                 360                 365             


Phe Asn Glu Thr Asn Gln Ser Val Ala Thr Val Asn Gln Ser Ser Gln 
    370                 375                 380                 


Leu Leu Glu Glu Asp Thr Ser Phe Asp Cys Arg Arg Glu Met Val His 
385                 390                 395                 400 


His Ala Ile Val Gln Gly Lys Arg Glu Asn Glu Ala Glu Thr Val Gln 
                405                 410                 415     


Glu Met Trp Ser Arg Ala Lys Gly Phe Lys Arg Ile Phe His Ala Ser 
            420                 425                 430         


Leu Met Ile Ala Phe Glu Leu Lys Gly Arg Glu Ile Pro Ile Val His 
        435                 440                 445             


Val His Arg Leu Ile Lys Ile Phe Thr Glu Thr Leu Leu Glu Glu Glu 
    450                 455                 460                 


Ile Gly Gly Leu Lys Glu Leu Phe Lys Met Ile Asp Thr Asp Asn Ser 
465                 470                 475                 480 


Gly Thr Ile Thr Phe Glu Glu Leu Lys Glu Ser Leu Arg Arg Leu His 
                485                 490                 495     


Asn Lys Asn Ile Pro Gln Asn Ser Thr Pro Gln Ser Leu Leu Gln Asn 
            500                 505                 510         


Thr Thr Pro Ala Pro Phe Phe Thr Met Phe Gln Gly Thr Pro Pro Asn 
        515                 520                 525             


Ser Thr Ser Tyr Phe Ser Asp Leu Lys Leu Gln Arg Met Val Phe Tyr 
    530                 535                 540                 


Leu Arg Leu Gln Glu Thr Tyr Thr Trp Asp Val Pro Val Thr Thr Lys 
545                 550                 555                 560 


Ile Lys Ser His Val Thr Thr Pro Tyr Asn Lys Lys Asp Gly Arg Val 
                565                 570                 575     


Phe Asn Lys Val Ile Ser His His Thr Thr Ile Gly Ile Ser Val Ser 
            580                 585                 590         


Asn Arg Ile Gly Gln Val Ile Glu Ser Gly Lys Val Asn Asn Phe Asp 
        595                 600                 605             


Lys Asn Val His Pro Trp Val Tyr Gly Asp Ser Glu Trp Met Leu Asp 
    610                 615                 620                 


Ser Lys Leu Leu Leu Leu Asn Glu Lys Glu Ser Val Leu Asn Tyr Asp 
625                 630                 635                 640 


Phe Lys Gly Ile Glu Arg Asp 
                645         


<210>  108
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  108

Met Ser Val Leu Ala Tyr Glu Ser Asn Asp Tyr Ser Ser Met Thr Leu 
1               5                   10                  15      


Lys Val Pro Ser Leu Ala Asp Leu Ser Ser Leu Glu Asp Asp Leu Ser 
            20                  25                  30          


Tyr Ser Leu Tyr Arg Glu Ser Cys Tyr Asp Leu Glu Gly Ile Ile Tyr 
        35                  40                  45              


Arg Lys Val Lys Glu Trp Val Thr Lys Asp Pro Thr Leu Ala Pro Ser 
    50                  55                  60                  


Leu Leu Arg Leu Gln Tyr His Asp Cys Val Val Arg Gly Cys Asp Ala 
65                  70                  75                  80  


Ser Ile Leu Leu Asp His Glu Gly Ser Glu Lys Thr Ser Asn Met Ser 
                85                  90                  95      


Lys Ser Leu Arg Gly Phe Glu Val Ile Asp Asp Ile Lys Ala Glu Ile 
            100                 105                 110         


Glu Lys Lys Cys Pro Lys Thr Val Ser Cys Ala Asp Ile Leu Thr Thr 
        115                 120                 125             


Val Ala Arg Asp Ala Thr Val Leu Ala Gly Gly Pro Tyr Trp Met Ile 
    130                 135                 140                 


Pro Tyr Gly Arg Lys Asp Gly Arg Val Ser Leu Ala Lys Glu Ala Ser 
145                 150                 155                 160 


Ile Val Pro Lys Gly Ser Glu Ser Val Thr Asn Leu Ile Glu Phe Phe 
                165                 170                 175     


Gln Ser Lys Gly Leu Asn Val Leu Asp Leu Val Ile Leu Ser Gly Ala 
            180                 185                 190         


His Thr Ile Gly Lys Thr Thr Cys Glu Ser Val Gln His Arg Leu Tyr 
        195                 200                 205             


Asp Tyr Lys Gly Thr Lys Lys Pro Asp Pro Ser Leu Asp Pro Lys Tyr 
    210                 215                 220                 


Leu Asn Tyr Leu Arg Arg Lys Cys Arg Trp Ala Ser Glu Asn Val Asn 
225                 230                 235                 240 


Leu Asp Gly Glu Thr Pro Asn Thr Phe Asp Thr Gln Tyr Tyr His Asn 
                245                 250                 255     


Leu Lys Lys Asn Met Gly Leu Leu Ser Thr Asp Gln Met Leu Tyr Ser 
            260                 265                 270         


Asp Ser Arg Thr Lys Pro Ile Ala Asp Gly Leu Ser Phe Gln Ser Ser 
        275                 280                 285             


Leu Phe Lys Asn Gln Phe Gly Val Ala Met Val Lys Leu Ser Ser Ile 
    290                 295                 300                 


Leu Asp Val Val Ser Gln Asp Glu Gly Glu Ile Arg Thr Asp Cys Lys 
305                 310                 315                 320 


Tyr Val Asn His 
                


<210>  109
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  109

Met Gln Lys Met Asn Ile Ile Ser Phe Leu Phe Ile Phe Val Phe Leu 
1               5                   10                  15      


Met Phe Ser Ile Val Thr Ala Ser Thr Asp Asp Tyr Gly Leu Ser Thr 
            20                  25                  30          


Lys Tyr Tyr Asp Arg Val Cys Ala Gln Ala Leu Pro Thr Ile Lys Arg 
        35                  40                  45              


Val Val Glu Asp Ala Val Ala Gln Glu Arg Arg Met Gly Ala Ser Leu 
    50                  55                  60                  


Leu Arg Leu His Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Asp Gln Thr Ser Thr Ile Asp Thr Glu Lys Asn Ala Ala 
                85                  90                  95      


Pro Asn Val Asn Ser Ala Arg Gly Phe Glu Val Ile Asp Arg Ile Lys 
            100                 105                 110         


Ser Glu Val Asp Lys Ile Cys Gly Arg Pro Val Val Ser Cys Ala Asp 
        115                 120                 125             


Ile Leu Thr Val Ala Ala Arg Asp Ser Val Val Ala Leu Gly Gly Pro 
    130                 135                 140                 


Thr Trp Asp Val Lys Leu Gly Arg Arg Asp Ser Thr Thr Ala Ser Gln 
145                 150                 155                 160 


Val Thr Ala Asn Val Thr Ile Pro Ser Pro Phe Met Asp Leu Pro Ala 
                165                 170                 175     


Leu Ile Lys Ser Phe Glu Asp Gln Gly Leu Asp Glu Glu Asp Leu Val 
            180                 185                 190         


Val Leu Ser Gly Ala His Thr Leu Gly Phe Ala Gln Cys Arg Thr Phe 
        195                 200                 205             


Arg Arg His Ile Tyr Asn Asp Ser Asn Ile Asp Pro Ala Phe Ala Gly 
    210                 215                 220                 


Gln Leu Arg Thr Asn Cys Pro Gln Val Gly Gly Asp Ser Asn Leu Val 
225                 230                 235                 240 


Pro Leu Asp Pro Thr Pro Ser Ser Phe Asp Thr Arg Tyr Phe Asn Asn 
                245                 250                 255     


Leu Val Ser Lys Arg Gly Val Leu Gly Ser Asp Gln Ala Leu Phe Asn 
            260                 265                 270         


Gly Gly Glu Thr Asp Glu Leu Val Ser Lys Tyr Asn Glu Asn Tyr Glu 
        275                 280                 285             


Glu Phe Phe Lys Asp Phe Ala Lys Ser Met Ile Lys Met Gly Asn Ile 
    290                 295                 300                 


Asn Leu Leu Thr Gly Asn Arg Gly Gln Ile Arg Asp Asn Cys Arg Arg 
305                 310                 315                 320 


Ile Asn Ser Gln 
                


<210>  110
<211>  437
<212>  PRT
<213>  Artemisia annua

<400>  110

Met Lys Val Ser Ser Phe Asn Lys Met Gly Ile Leu Val Ile Ile Leu 
1               5                   10                  15      


Leu Ala Thr Met Thr Asn Ile Ala Gln Gly Gln Gly Thr Arg Val Gly 
            20                  25                  30          


Phe Tyr Arg Thr Thr Cys Pro Arg Val Glu Ser Ile Val Gln Ser Ala 
        35                  40                  45              


Val Arg Gln Ala Val Arg Ser Asn Pro Thr Met Ala Pro Gly Leu Leu 
    50                  55                  60                  


Arg Ile Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Leu 
65                  70                  75                  80  


Leu Leu Asn Gly Ser Ser Ser Glu Lys Thr Ala Arg Pro Asn Leu Pro 
                85                  90                  95      


Leu Arg Gly Leu Gln Val Ile Asp Ala Ala Lys Ala Gln Leu Glu Arg 
            100                 105                 110         


Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Val Ala Leu Ala Ala 
        115                 120                 125             


Arg Asp Ser Thr Gly Gly Thr Ser Trp Gln Val Pro Leu Gly Arg Arg 
    130                 135                 140                 


Asp Gly Leu Val Ser Arg Ala Ser Asp Thr Ala Asn Leu Pro Ala Phe 
145                 150                 155                 160 


Asn Asp Pro Ile Ser Val Gln Ile Arg Lys Phe Ser Asp Lys Gly Leu 
                165                 170                 175     


Asn Thr Gln Asp Leu Val Ala Leu Val Gly His Thr Ile Gly Thr Ala 
            180                 185                 190         


Ala Cys Ser Val Phe Ser Tyr Arg Leu Tyr Asn Phe Asn Asn Thr Asn 
        195                 200                 205             


Arg Pro Asp Pro Ser Ile Asn Gln Ala Phe Leu Pro Gln Leu Arg Ala 
    210                 215                 220                 


Ile Cys Pro Asn Gly Gly Asn Gly Thr Thr Arg Val Gly Leu Asp Arg 
225                 230                 235                 240 


Gly Ser Val Asn Lys Phe Asp Asn Ser Phe Phe Lys Asn Leu Arg Asn 
                245                 250                 255     


Gly Arg Gly Val Leu Glu Ser Asp Ala Lys Leu Leu Ser Asn Pro Thr 
            260                 265                 270         


Thr Gln Arg Phe Val Gln Arg Phe Ser Gly Val Arg Gly Thr Pro Lys 
        275                 280                 285             


Leu Arg Phe Asn Val Glu Phe Gly Arg Ser Met Val Lys Met Gly Asn 
    290                 295                 300                 


Ile Gly Leu Lys Thr Gly Arg Gln Gly Glu Ile Cys Arg Arg Trp Lys 
305                 310                 315                 320 


Arg Arg Thr Cys Asp Thr Asp Tyr Asp Arg Asn Glu Leu Ile Thr Arg 
                325                 330                 335     


Ala Leu Lys Leu Gly Ala Cys Leu Leu Glu Ala Gly Asn Arg Ser Ala 
            340                 345                 350         


Ser Pro Cys Asn Cys Ser Gly Gly Gly Ala Phe Asn Arg Cys Leu Tyr 
        355                 360                 365             


Val Met Val Val Asn Lys Arg Arg Trp Thr Ser Gly Ser Ser Leu Cys 
    370                 375                 380                 


Tyr Gly Gln Arg Lys Lys Glu Lys Met His Val Leu Gly Gly Tyr Gln 
385                 390                 395                 400 


Val Ser Glu Lys Met His Met Leu Gly Gly Tyr Gln Gly Leu His Ile 
                405                 410                 415     


Gly Glu Lys Lys Lys Arg Ile Gln Phe Ile Lys Gly Phe Ala Asn Tyr 
            420                 425                 430         


Met Asn Asn Phe Tyr 
        435         


<210>  111
<211>  322
<212>  PRT
<213>  Artemisia annua

<400>  111

Met Gln Lys Met Asn Ile Ile Ser Phe Leu Ser Ile Phe Val Phe Leu 
1               5                   10                  15      


Met Phe Ser Ile Ala Thr Ala Ser Ser Asp Asp Tyr Gly Leu Ser Thr 
            20                  25                  30          


Glu Tyr Tyr Asp Arg Val Cys Pro Gln Ala Leu Pro Thr Ile Lys Arg 
        35                  40                  45              


Val Val Glu Asp Ala Met Ala Gln Glu Arg Arg Met Gly Ala Ser Leu 
    50                  55                  60                  


Leu Arg Leu His Phe His Asp Tyr Phe Val Asn Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Asp Gln Thr Ser Thr Ile Asp Thr Glu Lys Asn Ala Ala 
                85                  90                  95      


Pro Asn Val Asn Ser Ala Arg Gly Phe Glu Val Ile Asp Arg Ile Lys 
            100                 105                 110         


Ser Glu Val Asp Lys Ile Cys Gly Arg Pro Val Val Ser Cys Ala Asp 
        115                 120                 125             


Ile Leu Thr Val Ala Ala Arg Asp Ser Val Val Ala Leu Gly Gly Pro 
    130                 135                 140                 


Thr Trp Asp Ile Lys Leu Gly Arg Arg Asp Ser Thr Thr Ala Ser Gln 
145                 150                 155                 160 


Ala Ala Ala Asn Phe Lys Ile Pro Ser Pro Phe Met Asp Leu Pro Ala 
                165                 170                 175     


Leu Ile Lys Ser Phe Glu Asp Gln Gly Leu Asp Glu Glu Asp Leu Val 
            180                 185                 190         


Val Leu Ser Gly Ala His Thr Leu Gly Phe Ala Gln Cys Arg Thr Phe 
        195                 200                 205             


Arg Ser His Ile Tyr Asn Asp Thr Asn Ile Asp Pro Asp Phe Ala Gly 
    210                 215                 220                 


Gln Leu Arg Thr Asn Cys Pro Gln Val Gly Gly Asp Ser Asn Leu Ala 
225                 230                 235                 240 


Pro Leu Asp Pro Thr Pro Ser Ser Phe Asp Thr Arg Tyr Phe Asn Asn 
                245                 250                 255     


Leu Val Ser Lys Arg Gly Val Leu Gly Ser Asp Gln Ala Leu Phe Asn 
            260                 265                 270         


Gly Gly Glu Thr Asp Glu Leu Val Ser Lys Tyr Asn Glu Asn Tyr Glu 
        275                 280                 285             


Glu Phe Phe Glu Asp Phe Ala Lys Ser Met Ile Lys Met Gly Asn Ile 
    290                 295                 300                 


Asp Leu Leu Thr Gly Asn Arg Gly Gln Ile Arg Glu Asn Cys Arg Arg 
305                 310                 315                 320 


Ile Asn 
        


<210>  112
<211>  321
<212>  PRT
<213>  Artemisia annua

<400>  112

Met Ser Ser Tyr Asn Thr Phe Ala Pro Ile Leu Phe Leu Leu Leu Ile 
1               5                   10                  15      


Leu Ile Thr Asn Asn Thr Gln Ser Glu Ala Gln Leu Ser Thr Thr Phe 
            20                  25                  30          


Tyr Asp Gly Thr Cys Pro Asn Ala Leu His Thr Ile Arg Thr Ser Ile 
        35                  40                  45              


Arg Thr Ala Ile Ser Arg Glu Arg Arg Met Ala Ala Ser Ile Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser Ile Leu 
65                  70                  75                  80  


Leu Asp Asp Ser Pro Thr Ile Val Ser Glu Lys Asn Ala Phe Pro Asn 
                85                  90                  95      


Lys Gly Ser Leu Arg Gly Tyr Glu Val Ile Glu Ala Ala Lys Ser Glu 
            100                 105                 110         


Val Glu Lys Leu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Thr 
        115                 120                 125             


Ala Ala Ala Arg Asp Ala Ser Val Met Val Gly Gly Pro Ser Trp Ser 
    130                 135                 140                 


Val Lys Leu Gly Arg Arg Asp Ser Thr Thr Ala Ser Leu Asp Leu Ala 
145                 150                 155                 160 


Asn Thr Gly Leu Pro Ser Phe Lys Ala Pro Leu Asp Ser Leu Ile Ser 
                165                 170                 175     


Thr Phe Asn Asp Asn Gly Leu Ser Pro Arg Asp Met Val Ala Leu Ser 
            180                 185                 190         


Gly Ala His Thr Ile Gly Gln Ala Gln Cys Phe Ser Phe Arg Asp Arg 
        195                 200                 205             


Ile Tyr Ala Asn Gly Ser Asp Ile Asp Ala Gly Phe Ala Ser Thr His 
    210                 215                 220                 


Arg His Arg Cys Pro Ile Asn Glu Gly Asn Glu Asn Leu Ala Ala Leu 
225                 230                 235                 240 


Asp Leu Val Thr Pro Asn Ser Phe Asp Tyr Asn Tyr Phe Lys Asn Leu 
                245                 250                 255     


Ile Gln Lys Lys Gly Leu Leu Glu Ser Asp Gln Val Leu Phe Ser Gly 
            260                 265                 270         


Gly Ser Thr Asp Ser Ile Val Arg Glu Tyr Ser Lys Asn Thr Ser Asn 
        275                 280                 285             


Phe Lys Ser Asp Phe Ala Ala Ala Met Val Lys Met Ser Glu Phe Arg 
    290                 295                 300                 


Thr Ile Thr Gly Gln Glu Gly Val Ile Arg Ser Ile Cys Gly Ala Leu 
305                 310                 315                 320 


Pro 
    


<210>  113
<211>  553
<212>  PRT
<213>  Artemisia annua

<400>  113

Met Glu Ile Tyr Ser His Ile Arg Thr Pro Ile Leu Tyr Val Val Leu 
1               5                   10                  15      


Leu Ala Ala Met Ser Thr Leu Ala Leu Ser Cys Thr Gln Val Gly Phe 
            20                  25                  30          


Tyr Lys Thr Thr Cys Pro Pro Ala Glu Gly Ile Val Lys Ser Val Val 
        35                  40                  45              


Gln Ser Ala Ile Arg Ser Asn Leu Thr Ile Ala Pro Gly Leu Leu Arg 
    50                  55                  60                  


Met Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu 
65                  70                  75                  80  


Ile Asp Gly Leu Ser Ala Glu Lys Ile Val Val Gln Asn Leu Ala Leu 
                85                  90                  95      


Arg Gly Phe Glu Val Ile Gln Ala Ala Lys Ser Lys Leu Glu Thr Val 
            100                 105                 110         


Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg 
        115                 120                 125             


Asp Ser Val Val Gln Ser Gly Gly Met Asn Trp Glu Val Pro Thr Gly 
    130                 135                 140                 


Arg Arg Asp Gly Leu Val Ser Arg Asp Thr Asp Ala Lys Lys Leu Pro 
145                 150                 155                 160 


Gly Ser Thr Asp Asn Val Thr Ser Gln Ile Lys Lys Phe Ala Asp Lys 
                165                 170                 175     


Gly Leu Ser Ile Gln Asp Leu Val Thr Leu Val Gly Gly His Thr Ile 
            180                 185                 190         


Gly Thr Ala Ala Cys Gly Arg Phe Asp Tyr Arg Leu Tyr Asn Tyr Asn 
        195                 200                 205             


Asn Thr Asn Lys Pro Asp Pro Asp Ile Asp Gln Glu Phe Leu Ala Lys 
    210                 215                 220                 


Leu Lys Thr His Cys Pro Cys Lys Ser Asn Asn Thr Asn Arg Val Pro 
225                 230                 235                 240 


Leu Asp Thr Asn Ser Glu Thr Asn Phe Asp Asn Ser Tyr Tyr Gly Asn 
                245                 250                 255     


Val Arg Asn Gly Gln Gly Val Leu Glu Ser Asp Ser Lys Leu Trp Ser 
            260                 265                 270         


Asp Gly Arg Thr His Lys Phe Val Gln Gln Phe Leu Gly Ser Ser Asn 
        275                 280                 285             


Arg Leu Lys Phe Lys Lys Gln Phe Gly Arg Ala Met Val Lys Leu Ser 
    290                 295                 300                 


Asn Val Glu Val Lys Thr Gly Asn Gln Gly Glu Ile Pro Glu Lys Ile 
305                 310                 315                 320 


Val Val Gln Asn Leu Ala Leu Arg Gly Phe Glu Val Ile Gln Ala Ala 
                325                 330                 335     


Lys Ser Lys Leu Glu Thr Val Cys Pro Gly Val Val Ser Cys Ala Asp 
            340                 345                 350         


Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val Gln Ser Gly Gly Met 
        355                 360                 365             


Asn Trp Glu Val Pro Thr Gly Arg Arg Asp Gly Leu Val Ser Arg Asp 
    370                 375                 380                 


Thr Asp Ala Lys Lys Leu Pro Gly Ser Thr Asp Asn Val Thr Ser Gln 
385                 390                 395                 400 


Ile Lys Lys Phe Ala Asp Lys Gly Leu Ser Ile Gln Asp Leu Val Thr 
                405                 410                 415     


Leu Val Gly Gly His Thr Ile Gly Thr Ala Ala Cys Gly Arg Phe Asp 
            420                 425                 430         


Tyr Arg Leu Tyr Asn Tyr Asn Asn Thr Asn Lys Pro Asp Pro Asp Ile 
        435                 440                 445             


Asp Gln Glu Phe Leu Ala Lys Leu Lys Thr His Cys Pro Cys Lys Ser 
    450                 455                 460                 


Asn Asn Thr Asn Arg Val Pro Leu Asp Thr Asn Ser Glu Thr Asn Phe 
465                 470                 475                 480 


Asp Asn Ser Tyr Tyr Gly Asn Val Arg Asn Gly Gln Gly Val Leu Glu 
                485                 490                 495     


Ser Asp Ser Lys Leu Trp Ser Asp Gly Arg Thr His Lys Phe Val Gln 
            500                 505                 510         


Gln Phe Leu Gly Ser Ser Asn Arg Leu Lys Phe Lys Lys Gln Phe Gly 
        515                 520                 525             


Arg Ala Met Val Lys Leu Ser Asn Val Glu Val Lys Thr Gly Asn Gln 
    530                 535                 540                 


Gly Glu Ile Arg Arg Glu Leu Lys Phe 
545                 550             


<210>  114
<211>  323
<212>  PRT
<213>  Artemisia annua

<400>  114

Met Ala Ser Ser Lys Ile Ile Ser Phe Ala Gln Val Ala Ser Val Leu 
1               5                   10                  15      


Cys Leu Met Ser Ile Thr Ser Ser Gly Gln Leu Thr His Asp Phe Tyr 
            20                  25                  30          


Ser Glu Ser Cys Pro Ser Val Phe Glu Ala Val Gly Ser Val Val Gln 
        35                  40                  45              


Asp Ala Val Ser Arg Glu Lys Arg Met Gly Ala Ser Leu Leu Arg Leu 
    50                  55                  60                  


His Phe His Asp Cys Phe Val Asn Gly Cys Asp Gly Ser Val Leu Leu 
65                  70                  75                  80  


Asp Asp Thr Pro Ser Phe Thr Gly Glu Lys Thr Ala Gly Pro Asn Ala 
                85                  90                  95      


Asn Ser Ala Arg Gly Phe Asp Val Ile Asp Asp Val Lys Ser Lys Val 
            100                 105                 110         


Glu Glu Val Cys Pro Gly Val Val Ser Cys Ala Asp Val Leu Ala Ile 
        115                 120                 125             


Ala Ala Leu Glu Ser Val Val Ala Leu Gly Gly Pro Ala Trp Glu Ile 
    130                 135                 140                 


Lys Leu Gly Arg Arg Asp Ser Arg Thr Ala Ser Leu Ser Ala Ala Asp 
145                 150                 155                 160 


Gly Gly Val Ile Pro Pro Pro Ser Ser Thr Leu Ser Asn Leu Ile Asn 
                165                 170                 175     


Gln Phe Gln Ala Gln Gly Leu Ser Val Lys Asp Leu Val Ala Leu Ser 
            180                 185                 190         


Gly Ala His Thr Ile Gly Gln Ala Arg Cys Thr Thr Phe Arg Ala Arg 
        195                 200                 205             


Val His Asn Asp Thr Asn Ile Asp Thr Ser Phe Ala Arg Ser Leu Gln 
    210                 215                 220                 


Ser Asn Cys Pro Leu Pro Thr Gly Leu Gly Asp Asn Asn Leu Ala Pro 
225                 230                 235                 240 


Leu Asp Val Arg Ser Pro Thr His Phe Asp Asn Ser Tyr Phe Arg Asn 
                245                 250                 255     


Leu Ile Thr Glu Lys Gly Leu Leu Thr Ser Asp Gln Gln Leu Tyr Ser 
            260                 265                 270         


Gly Gly Ala Thr Asp Phe Phe Val Glu Gln Tyr Ser Gln Asn Pro Glu 
        275                 280                 285             


Ser Phe His Glu Asp Phe Ala Ala Ala Met Ile Lys Met Gly Asp Ile 
    290                 295                 300                 


Ser Pro Leu Thr Gly Ser Asn Gly Glu Ile Arg Thr Asn Cys Arg Val 
305                 310                 315                 320 


Val Asn Ser 
            


<210>  115
<211>  267
<212>  PRT
<213>  Artemisia annua

<400>  115

Met Leu Arg Leu His Phe His Asp Cys Phe Val Glu Gly Cys Asp Gly 
1               5                   10                  15      


Ser Ile Leu Ile Asp Asn Gly Asn Asn Ser Glu Arg Ile Ala Asn Gly 
            20                  25                  30          


His Gln Gly Val Arg Gly Tyr Asp Val Ile Glu Asn Ala Lys Ala Gln 
        35                  40                  45              


Leu Glu Ser Met Cys Pro Gly Val Val Ser Cys Ala Asp Ile Val Ala 
    50                  55                  60                  


Met Ala Ala Arg Asp Ala Val Ala Leu Ser His Gly Pro Val Tyr Gln 
65                  70                  75                  80  


Val Glu Thr Gly Arg Lys Asp Gly Leu Val Ser Arg Met Glu Leu Ala 
                85                  90                  95      


Gly Arg Met Pro Asp Val Gln Asp Ser Ile Gln Ile Leu Lys Gln Lys 
            100                 105                 110         


Phe Ile Glu Lys Gly Leu Asn Asp Arg Asp Leu Val Ile Leu Ser Ala 
        115                 120                 125             


Ala His Thr Ile Gly Thr Thr Ala Cys Phe Phe Met Thr Thr Arg Leu 
    130                 135                 140                 


Tyr Asp Phe Ala Ser Ser Glu Gly Pro Asp Pro Ser Ile Asn Pro Ser 
145                 150                 155                 160 


Phe Leu Pro Glu Leu Thr Ser Ala Cys Pro Lys Glu Gly Asn Pro Asn 
                165                 170                 175     


Asp Arg Leu Pro Met Asp His Gly Ser Gly Asp Ile Phe Asp Lys Gln 
            180                 185                 190         


Ile Phe Gln Asn Ile Arg Ser Gly Phe Ala Val Leu Gln Ser Asp Ala 
        195                 200                 205             


Lys Leu Met Asp Asp Pro Thr Thr Lys Gly Ile Val Asp Ser Tyr Phe 
    210                 215                 220                 


Gly Leu Leu Ser Pro Leu Ile Gly Pro Ser Phe Glu Gly Asp Phe Val 
225                 230                 235                 240 


Lys Ser Met Val Arg Met Gly Arg Ile Gly Val Lys Thr Gly Ser Ser 
                245                 250                 255     


Gly Asp Ile Arg Arg Val Cys Lys Ala Phe Asn 
            260                 265         


<210>  116
<211>  360
<212>  PRT
<213>  Artemisia annua

<400>  116

Met Gly Ser Ser Val Ile Val Lys Phe Ala Phe Val Met Phe Leu Val 
1               5                   10                  15      


Gly Val Ser Ser Ala Gln Leu Ser Thr Asn Phe Tyr Ala Lys Ser Cys 
            20                  25                  30          


Pro Asn Leu Phe Leu Ala Val Asn Ser Ala Val Arg Ser Ala Ile Ser 
        35                  40                  45              


Arg Glu Thr Arg Met Gly Ala Ser Leu Leu Arg Leu His Phe His Asp 
    50                  55                  60                  


Cys Phe Val Asn Gly Cys Asp Gly Ser Ile Leu Leu Asp Asp Thr Ser 
65                  70                  75                  80  


Ser Phe Thr Gly Glu Lys Asn Ala Ala Pro Asn Phe Arg Ser Ala Arg 
                85                  90                  95      


Gly Phe Asp Val Val Asp Asn Ile Lys Ser Ala Val Glu Arg Ala Cys 
            100                 105                 110         


Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Ile Thr Ala Arg Asp 
        115                 120                 125             


Ser Val His Ile Leu Gly Gly Pro Tyr Trp Asn Val Lys Leu Gly Arg 
    130                 135                 140                 


Arg Asp Ser Arg Thr Ala Ser Gln Ala Ala Ala Asn Asn Ser Ile Pro 
145                 150                 155                 160 


Pro Pro Thr Ser Ser Leu Ser Ala Leu Ile Ser Ser Phe Ser Arg Val 
                165                 170                 175     


Gly Leu Ser Ala Lys Asp Met Val Ala Leu Arg Asp Ser Arg Thr Ala 
            180                 185                 190         


Ser Gln Ala Ala Ala Asn Asn Ser Ile Pro Pro Pro Thr Ser Ser Leu 
        195                 200                 205             


Ser Ala Leu Ile Ser Ser Phe Ser Arg Val Gly Leu Ser Ala Lys Asp 
    210                 215                 220                 


Met Val Ala Leu Ser Gly Ser His Thr Ile Gly Gln Ala Arg Cys Thr 
225                 230                 235                 240 


Thr Phe Arg Ala Arg Ile Tyr Asn Glu Thr Asn Asn Leu Asp Ala Ser 
                245                 250                 255     


Phe Gly Ala Ser Arg Arg Ser Asn Cys Pro Arg Ala Ser Gly Ser Gly 
            260                 265                 270         


Asp Asn Asn Leu Ala Pro Leu Asp Val Gln Thr Pro Asn Ala Phe Asn 
        275                 280                 285             


Asn Asp Tyr Tyr Lys Asn Leu Ile Ala Lys Lys Gly Leu Leu His Ser 
    290                 295                 300                 


Asp Gln Gln Leu Phe Asn Gly Gly Ser Ala Asp Ser Thr Val Arg Gln 
305                 310                 315                 320 


Tyr Ser Ser Asn Pro Arg Gln Phe Ser Ser Asp Phe Ala Ala Ala Met 
                325                 330                 335     


Ile Lys Met Gly Asp Phe Arg Pro Leu Thr Gly Ser Ser Gly Glu Ile 
            340                 345                 350         


Arg Arg Asn Cys Arg Arg Pro Asn 
        355                 360 


<210>  117
<211>  322
<212>  PRT
<213>  Artemisia annua

<400>  117

Met Gly Ser Ser Lys Ile Met Ser Phe Ser Phe Leu Ala Cys Thr Leu 
1               5                   10                  15      


Phe Leu Met Ser Gly Thr Ser Leu Ala Gln Leu Thr Pro Asp Phe Tyr 
            20                  25                  30          


Asp Leu Thr Cys Pro Lys Val Ile Glu Val Val Gly Ser Val Val Lys 
        35                  40                  45              


Ala Ala Val Leu Arg Glu Lys Arg Met Gly Ala Ser Leu Leu Arg Leu 
    50                  55                  60                  


His Phe His Asp Cys Phe Val Asn Gly Cys Asp Gly Ser Ile Leu Leu 
65                  70                  75                  80  


Asp Asp Thr Pro Ser Phe Arg Gly Glu Lys Thr Ala Asn Pro Asn Val 
                85                  90                  95      


Asn Ser Ala Arg Gly Phe Glu Val Ile Asp Asp Ile Lys Ser His Val 
            100                 105                 110         


Glu Arg Leu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Ile 
        115                 120                 125             


Ala Ala Leu Glu Ser Val Leu Ala Leu Gly Gly Pro Tyr Trp Arg Val 
    130                 135                 140                 


Asn Leu Gly Arg Arg Asp Ser Ile Ser Ala Ser Phe Asp Ala Ala Asn 
145                 150                 155                 160 


Gly Asn Ala Ile Pro Pro Pro Thr Ser Ser Leu Asp Asn Leu Val Arg 
                165                 170                 175     


Thr Phe Gln Ala Val Gly Leu Thr Ala Asp Asp Met Val Ala Leu Ala 
            180                 185                 190         


Gly Ala His Thr Ile Gly Gln Ala Arg Cys Thr Ser Phe Arg Pro His 
        195                 200                 205             


Val Tyr Asn Asp Thr Asn Val Asp Pro Leu Phe Ala Ser Leu Arg Arg 
    210                 215                 220                 


Thr Asn Cys Pro Ile Pro Asn Gly Leu Gly Asp Asn Asn Leu Ala Pro 
225                 230                 235                 240 


Leu Asp Ala Arg Thr Ser Asn His Phe Asp Asn Ser Tyr Tyr Asn Asn 
                245                 250                 255     


Leu Leu Ile Asn Gln Gly Leu Leu His Ser Asp Met Gln Leu His Ser 
            260                 265                 270         


Gly Gly Phe Thr Asp Arg Leu Val Glu Glu Tyr Gly Arg Asp Pro Ile 
        275                 280                 285             


Lys Phe Asn Val Asp Phe Ser Ala Ala Met Ile Lys Met Gly Asp Ile 
    290                 295                 300                 


Ser Pro Leu Met Gly Asn Asp Gly Glu Ile Arg Arg Asn Cys Arg Val 
305                 310                 315                 320 


Pro Asn 
        


<210>  118
<211>  322
<212>  PRT
<213>  Artemisia annua

<400>  118

Met Gly Ser Ser Lys Ile Met Ser Phe Ser Phe Leu Ala Cys Thr Leu 
1               5                   10                  15      


Phe Leu Met Ser Gly Thr Ser Leu Ala Gln Leu Thr Pro Asp Phe Tyr 
            20                  25                  30          


Asp Leu Thr Cys Pro Lys Val Ile Glu Val Val Gly Ser Val Val Lys 
        35                  40                  45              


Ala Ala Val Leu Arg Glu Lys Arg Met Gly Ala Ser Leu Leu Arg Leu 
    50                  55                  60                  


His Phe His Asp Cys Phe Val Asn Gly Cys Asp Gly Ser Ile Leu Leu 
65                  70                  75                  80  


Asp Asp Thr Pro Ser Phe Arg Gly Glu Lys Thr Ala Asn Pro Asn Val 
                85                  90                  95      


Asn Ser Ala Arg Gly Phe Glu Val Ile Asp Asp Ile Lys Ser His Val 
            100                 105                 110         


Glu Arg Leu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Ile 
        115                 120                 125             


Ala Ala Leu Glu Ser Val Leu Ala Leu Gly Gly Pro Tyr Trp Arg Val 
    130                 135                 140                 


Asn Leu Gly Arg Arg Asp Ser Ile Ser Ala Ser Phe Asp Ala Ala Asn 
145                 150                 155                 160 


Gly Asn Ala Ile Pro Pro Pro Thr Ser Ser Leu Asp Asn Leu Val Arg 
                165                 170                 175     


Thr Phe Gln Ala Val Gly Leu Thr Ala Asp Asp Met Val Ala Leu Ala 
            180                 185                 190         


Gly Ala His Thr Ile Gly Gln Ala Arg Cys Thr Ser Phe Arg Pro His 
        195                 200                 205             


Val Tyr Asn Asp Thr Asn Val Asp Pro Leu Phe Ala Ser Leu Arg Arg 
    210                 215                 220                 


Thr Asn Cys Pro Ile Pro Asn Gly Val Gly Asp Asn Asn Leu Ala Pro 
225                 230                 235                 240 


Leu Asp Ala Arg Thr Ser Asn His Phe Asp Asn Ser Tyr Tyr Asn Asn 
                245                 250                 255     


Leu Leu Ile Asn Gln Gly Leu Leu His Ser Asp Met Gln Leu His Ser 
            260                 265                 270         


Gly Gly Phe Thr Asp Arg Leu Val Glu Glu Tyr Gly Arg Asp Pro Ile 
        275                 280                 285             


Lys Phe Asn Val Asp Phe Ser Ala Ala Met Ile Lys Met Gly Asp Ile 
    290                 295                 300                 


Ser Pro Leu Met Gly Asn Asp Gly Glu Ile Arg Arg Asn Cys Arg Val 
305                 310                 315                 320 


Pro Asn 
        


<210>  119
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  119

Met Ala Ser Ser Lys Ile Ile Ser Phe Ala Leu Val Ala Ser Val Leu 
1               5                   10                  15      


Cys Leu Met Ser Ile Thr Ser Ser Gly His Glu Leu Thr His Asp Phe 
            20                  25                  30          


Tyr Ser Arg Ser Cys Pro Arg Val Phe Glu Val Val Gly Ser Val Val 
        35                  40                  45              


Arg Ser Ala Val Ser Arg Glu Lys Arg Met Gly Ala Ser Leu Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Val Asn Gly Cys Asp Gly Ser Val Leu 
65                  70                  75                  80  


Leu Asp Asp Thr Pro Ser Phe Thr Gly Glu Lys Thr Ala Gly Pro Asn 
                85                  90                  95      


Ala Asn Ser Ala Arg Gly Phe Asn Val Ile Asp Ala Val Lys Ser Lys 
            100                 105                 110         


Val Glu Glu Ala Cys Pro Gly Val Val Ser Cys Ala Asp Val Leu Ala 
        115                 120                 125             


Ile Thr Ala Leu Glu Ser Val Val Ala Leu Gly Gly Pro Ala Trp Arg 
    130                 135                 140                 


Ile Lys Leu Gly Arg Arg Asp Ser Arg Thr Ala Ser Leu Ser Ala Ala 
145                 150                 155                 160 


Asn Ser Gly Val Ile Pro Ser Pro Ser Ser Thr Leu Ser Asn Leu Ile 
                165                 170                 175     


Asn Arg Phe Gln Ala Gln Gly Leu Ser Val Lys Asp Leu Val Ala Leu 
            180                 185                 190         


Ser Gly Ala His Thr Ile Gly Gln Ala Arg Cys Thr Thr Phe Arg Ala 
        195                 200                 205             


Arg Val His Asn Asp Ser Asn Ile Asp Thr Ser Phe Ala Arg Ser Arg 
    210                 215                 220                 


Gln Ser Asn Cys Pro Leu Pro Thr Gly Leu Gly Asp Asn Asn Leu Ala 
225                 230                 235                 240 


Pro Leu Asp Val Lys Ser Pro Ala Tyr Phe Asp Asn Ser Tyr Phe Arg 
                245                 250                 255     


Asn Leu Ile Asn Glu Lys Gly Leu Leu Arg Ser Asp Gln Gln Leu His 
            260                 265                 270         


Ser Gly Gly Ala Thr Asp Phe Phe Val Glu Gln Tyr Ser Arg Asn Pro 
        275                 280                 285             


Glu Arg Phe His Glu Asp Phe Ala Ala Ala Met Ile Lys Met Gly Asp 
    290                 295                 300                 


Ile Ser Pro Leu Thr Gly Arg Asn Gly Glu Ile Arg Lys Asn Cys Arg 
305                 310                 315                 320 


Val Val Asn Ser 
                


<210>  120
<211>  262
<212>  PRT
<213>  Artemisia annua

<400>  120

Met Ala Ala Leu Leu Ile Arg Leu His Phe His Asp Cys Phe Val Gln 
1               5                   10                  15      


Gly Cys Asp Ala Ser Ile Leu Leu Asn Asp Pro Ala Thr Thr Glu Arg 
            20                  25                  30          


Thr Ala Gln Ser Asn Ile Gly Val Gly Gly Tyr Glu Val Ile Asp Ala 
        35                  40                  45              


Ala Lys Ser Ala Leu Glu Thr Ile Cys Pro Gly Ile Val Ser Cys Ala 
    50                  55                  60                  


Asp Ile Leu Thr Val Ala Ala Arg Asp Ala Ser Val Met Val Gly Gly 
65                  70                  75                  80  


Pro Ser Trp Ser Val Arg Leu Gly Arg Arg Asp Ser Thr Thr Ala Asn 
                85                  90                  95      


Leu Ala Gln Ala Asn Asn Leu Pro Arg Ala Asp Gln Asp Leu Gln Ser 
            100                 105                 110         


Leu Ile Ser Asp Phe Arg Asp Lys Gly Leu Ser Glu Arg Asp Met Val 
        115                 120                 125             


Ala Leu Ser Gly Ser His Thr Ile Gly Gln Ser Arg Cys Val Ala Phe 
    130                 135                 140                 


Arg Ala Arg Ile Tyr Ser Asn Gly Thr Asp Ile Asp Ala Asn Phe Ala 
145                 150                 155                 160 


Ser Thr Arg Arg Arg Gly Cys Pro Ser Asn Arg Gly Asn Gly Asp Glu 
                165                 170                 175     


Asn Leu Ala Pro Leu Asp Leu Val Thr Pro Asn Ser Phe Asp Asn Asn 
            180                 185                 190         


Tyr Phe Arg Asn Leu Val Gln Arg Arg Gly Leu Leu Gln Ser Asp Gln 
        195                 200                 205             


Val Leu Phe Ser Gly Gly Ser Ser Asp Ser Ile Val Leu Glu Tyr Ser 
    210                 215                 220                 


Asn Asn Arg Ala Arg Phe Ala Ser Asp Phe Ala Ala Ala Met Val Arg 
225                 230                 235                 240 


Met Ser Glu Ile Asp Leu Leu Thr Gly Asn Asn Gly Ile Ile Arg Thr 
                245                 250                 255     


Ile Cys Ser Ala Ala Asn 
            260         


<210>  121
<211>  494
<212>  PRT
<213>  Artemisia annua

<400>  121

Met Ala Asn Gly Lys Ala Val Ala Leu Ala Val Gly Phe Ile Phe Leu 
1               5                   10                  15      


Asn Leu Ala Gly His Cys Tyr Gly Tyr Tyr Gly Gly Leu Gln Tyr Gly 
            20                  25                  30          


Phe Tyr Lys Gly Lys Cys Arg Thr Ser Asp Val Glu Asp Ile Val Ser 
        35                  40                  45              


Lys Thr Val Tyr Ser Lys Phe Leu Arg Asp Arg Thr Ile Ala Pro Ala 
    50                  55                  60                  


Leu Ile Arg Met Gln Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala 
65                  70                  75                  80  


Ser Ile Leu Leu Asp Gly Pro Asn Ser Glu Lys Thr Ala Pro Pro Asn 
                85                  90                  95      


Leu Ser Val Arg Gly Phe Asp Val Ile Asp Ala Ala Lys Ala Ala Val 
            100                 105                 110         


Glu Lys Val Cys Pro Gly Val Val Ser Cys Ala Asp Ile Ile Ile Met 
        115                 120                 125             


Ala Thr Arg Asp Val Val Ser Leu Ser Gly Gly Gly Arg Tyr Lys Val 
    130                 135                 140                 


Gln Thr Gly Arg Arg Asp Gly Leu Val Ser Leu Ala Gln Asn Thr Ile 
145                 150                 155                 160 


Ser Leu Pro Pro Pro Thr Ala Ser Val Ala Thr Ala Ile Gln Leu Phe 
                165                 170                 175     


Ala Leu Lys Gly Leu Thr Ala Thr Asp Met Ile Tyr Leu Phe Gly Gly 
            180                 185                 190         


His Ser Ile Gly Ile Ala His Cys Ser Leu Phe Lys Asp Arg Leu Tyr 
        195                 200                 205             


Asn Phe Lys Asn Thr Gly Lys Pro Asp Pro Thr Met Asp Trp Ala Leu 
    210                 215                 220                 


Leu Thr Ser Leu Arg Lys Thr Cys Ala Gln Asn Ala Thr Ile Asp Arg 
225                 230                 235                 240 


Thr Ala Asn Leu Asp Gln Asn Pro Tyr Ser Ser Ala Val Val Asp Lys 
                245                 250                 255     


Ser Phe Tyr Ser Gln Ile Ile Lys Arg Arg Gly Val Leu Lys Phe Asp 
            260                 265                 270         


Gln Asp Leu Ala Ser Asp Arg Leu Ser Lys Ser Thr Val Ala Arg Ile 
        275                 280                 285             


Ala Arg Ser Ser Asn Phe Asn Thr Lys Phe Gly Gln Ala Met Val Lys 
    290                 295                 300                 


Leu Gly Pro Val Gln Ala Ser Asp Pro Asp Ile Leu Phe Asp Tyr Ile 
305                 310                 315                 320 


Val Pro Pro Asn Val Thr Lys Val Asp Gly Asp Phe Phe Thr Tyr Thr 
                325                 330                 335     


Lys Ile Arg Gly Phe Phe Asp Gly Ser Ser Asn Ser Ala Asp Ser Lys 
            340                 345                 350         


Ser Met Leu Ala Ser Met Thr Glu Phe Pro Ala Leu Asn Gly Gln Ser 
        355                 360                 365             


Val Ser Leu Ser Leu Leu Arg Leu Ala Pro Gly Gly Val Ser Ala Pro 
    370                 375                 380                 


His Thr Arg Pro His Ala Thr Gly Leu Phe Phe Val Leu Glu Gly Thr 
385                 390                 395                 400 


Phe Glu Val Gly Phe Val Asp Thr Thr Asn Lys Leu Tyr Thr Gln Thr 
                405                 410                 415     


Leu Gln Thr Gly Asp Met Phe Ile Phe Pro Lys Gly Leu Val His Tyr 
            420                 425                 430         


Gln Tyr Asn Ser Asp Met Lys Asn Pro Ala Val Ala Val Ala Ala Phe 
        435                 440                 445             


Gly Ser Ala Ser Ala Ser Thr Val Leu Ile Pro Thr Thr Leu Phe Asp 
    450                 455                 460                 


Ile Asp Ile Glu Asp Val Ile Leu Ala Lys Ser Phe Lys Thr Asn Val 
465                 470                 475                 480 


Ala Thr Ile Arg Lys Leu Lys Ala Gly Val Gly Ser Lys Ser 
                485                 490                 


<210>  122
<211>  335
<212>  PRT
<213>  Artemisia annua

<400>  122

Met Lys Arg Gln Val Cys Leu Phe Leu Ser Ile Val Val Ile Leu Ala 
1               5                   10                  15      


Ala Ser Ser Val Asp Thr Val Ala Ala Asp Gly Leu Pro Pro Glu Ala 
            20                  25                  30          


Ala Pro Leu Ile Arg His Phe Tyr Lys Val His Asn Thr Cys Asp Asn 
        35                  40                  45              


Val Glu Pro Phe Ile Arg His Gln Met Lys Leu Met Phe Asp Lys Asp 
    50                  55                  60                  


Lys Thr Ile Thr Pro Lys Leu Val Lys Leu Leu Tyr Ala Asp Cys Met 
65                  70                  75                  80  


Ile Asn Gly Cys Asp Ala Ser Ile Leu Leu Asp Gly Pro Asn Thr Glu 
                85                  90                  95      


Lys Ser Ser Pro Lys Thr Arg Gly Leu Ala Ala Phe Val Ile Ile Asp 
            100                 105                 110         


Arg Leu Lys Thr Val Val Glu Ala Arg Cys Pro Gly Ala Val Ser Cys 
        115                 120                 125             


Ala Asp Ile Leu Asn Ile Ala Thr Arg Asp Ala Ile Phe Tyr Ser Gly 
    130                 135                 140                 


Gly Pro Ser Tyr Pro Val Phe Leu Gly Arg Arg Asp Gly Lys Lys Ser 
145                 150                 155                 160 


Asp Ala Ser Trp Val Asp Leu Pro Pro Pro Ser Ile Ser Trp Glu Ala 
                165                 170                 175     


Ser Leu Ala Tyr Phe Thr Ser Lys Gly Leu Asp Val Gln Asp Met Val 
            180                 185                 190         


Thr Leu Leu Gly Gly His Met Met Gly Arg Thr Arg Cys Ser Asn Val 
        195                 200                 205             


Leu Asp Arg Leu Tyr Asn Phe Asn Asn Thr Gly Lys Pro Asp Pro Thr 
    210                 215                 220                 


Met Glu Pro Val Thr Leu Thr Tyr Leu Gln Lys Gln Cys Pro Lys Lys 
225                 230                 235                 240 


Val Lys Leu Gly Gln Ala Asn Pro Leu Ile Asn Leu Asn Pro Gln Asn 
                245                 250                 255     


Pro Thr His Lys Phe Thr Asn Ser Tyr Tyr Ser Arg Ile Leu Ala Asn 
            260                 265                 270         


Lys Ala Val Leu Gly Val Asp Gln Gln Met Leu Tyr Gly Asp Asp Thr 
        275                 280                 285             


His Glu Leu Thr Asp Glu Phe Ala Lys Gly Leu Glu Asp Phe Arg Gly 
    290                 295                 300                 


Ala Phe Ala Tyr Ser Met Ser Arg Met Gly Gly Leu Lys Val Leu Thr 
305                 310                 315                 320 


Gly Thr Lys Gly Glu Ile Arg Arg Asn Cys His Val Val Asn Lys 
                325                 330                 335 


<210>  123
<211>  332
<212>  PRT
<213>  Artemisia annua

<400>  123

Met Lys Phe Arg Gln Ile Phe Leu Ser Met Phe Ile His Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu His Ala Ser Asp Pro Pro Leu Ser Leu Asp Tyr Tyr 
            20                  25                  30          


Lys Ser Thr Cys Pro Asn Ala Glu Ala Ile Val Arg Lys Glu Met Glu 
        35                  40                  45              


Cys Ala Val Leu Ser Asp Pro Arg Asn Ala Ala Tyr Ile Leu Arg Leu 
    50                  55                  60                  


His Phe His Asp Cys Phe Val Gln Gly Cys Asp Gly Ser Val Leu Leu 
65                  70                  75                  80  


Glu Asp Thr Val Thr Phe Gln Gly Glu Lys Asn Ala Pro Thr Asn Leu 
                85                  90                  95      


Asp Ala Leu Lys Gly Phe Asp Ile Ile Asp Arg Ile Lys Asn Lys Leu 
            100                 105                 110         


Glu Ser Glu Cys Pro Gly Thr Val Ser Cys Ala Asp Val Leu Thr Ile 
        115                 120                 125             


Ala Ala Arg Asp Ala Thr Ile Leu Val Gly Gly Pro Tyr Trp His Val 
    130                 135                 140                 


Pro Val Gly Arg Lys Asp Ser Arg Thr Gly Ser Phe Ala Gln Val Glu 
145                 150                 155                 160 


Thr Asn Ile Pro Gly Ala Asn Asp Gly Leu Leu Ser Met Ile Ser Lys 
                165                 170                 175     


Phe Met Tyr Gln Gly Leu Ser Val Thr Asp Met Val Ala Leu Ser Gly 
            180                 185                 190         


Ala His Thr Ile Gly Met Ala Arg Cys Thr Asn Tyr Arg Asp Arg Ile 
        195                 200                 205             


Tyr Gly Asp Tyr Gln Ile Thr Ser Ile Ala Asn Pro Ile Ala Lys Ser 
    210                 215                 220                 


Asn Leu Lys Thr Leu Gln Ser Thr Cys Pro Ala Ala Gly Gly Gly Glu 
225                 230                 235                 240 


Asn Asn Glu Ala Ala Met Asp Tyr Val Ser Pro Asn Leu Phe Asp Asn 
                245                 250                 255     


Ser Tyr Tyr Leu Leu Leu Leu Asn Gly Glu Gly Leu Leu Asn Ser Asp 
            260                 265                 270         


Gln Glu Leu Tyr Ser Ser Val Leu Gly Ile Glu Thr Lys Lys Leu Val 
        275                 280                 285             


Lys Lys Tyr Ala Leu Glu Pro Ile Ala Phe Phe Glu Gln Phe Ser Glu 
    290                 295                 300                 


Ser Met Val Lys Leu Gly Asn Ile Thr Asn Pro Glu Thr Tyr Val Asn 
305                 310                 315                 320 


Gly Glu Val Arg Lys Asn Cys Arg Phe Met Asn Thr 
                325                 330         


<210>  124
<211>  92
<212>  PRT
<213>  Artemisia annua

<400>  124

Met Gly Ala His Thr Leu Gly Phe Ser His Cys Asp Gln Phe Ser Asn 
1               5                   10                  15      


Arg Ile Tyr Asn Phe Ser Lys Gln Asn Pro Val Asp Pro Ser Leu Asn 
            20                  25                  30          


Pro Ser Tyr Ala Thr Gln Leu Gln Gln Gln Cys Pro Lys Asn Val Asp 
        35                  40                  45              


Pro Arg Ile Ala Ile Asn Met Asp Pro Asn Thr Pro Arg Thr Phe Asp 
    50                  55                  60                  


Asn Val Tyr Tyr Lys Asn Leu Gln Asn Gly Gln Gly Leu Tyr Thr Ser 
65                  70                  75                  80  


Asp Gln Val Leu Leu Thr Leu Asp Gln Asn Arg Leu 
                85                  90          


<210>  125
<211>  298
<212>  PRT
<213>  Artemisia annua

<400>  125

Met Lys Val Ser Ser Phe Asn Lys Met Gly Ile Leu Val Ile Ile Leu 
1               5                   10                  15      


Leu Ala Thr Met Thr Asn Ile Ala Gln Gly Gln Gly Thr Arg Val Gly 
            20                  25                  30          


Phe Tyr Arg Thr Thr Cys Pro Arg Val Glu Ser Ile Val Gln Ser Ala 
        35                  40                  45              


Val Arg Gln Ala Val Arg Ser Asn Pro Thr Met Ala Pro Gly Leu Leu 
    50                  55                  60                  


Arg Ile Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Leu 
65                  70                  75                  80  


Leu Leu Asn Gly Ser Ser Ser Glu Lys Thr Ala Arg Pro Asn Leu Pro 
                85                  90                  95      


Leu Arg Gly Phe Gln Val Ile Asp Ala Ala Lys Ala Gln Leu Glu Arg 
            100                 105                 110         


Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Val Ala Leu Ala Ala 
        115                 120                 125             


Arg Asp Ser Val Val Leu Thr Gly Gly Thr Ser Trp Gln Val Pro Leu 
    130                 135                 140                 


Gly Arg Arg Asp Gly Phe Val Ser Arg Ala Ser Asp Thr Thr Asn Leu 
145                 150                 155                 160 


Pro Ala Phe Asn Asp Pro Ile Thr Val Gln Ile Arg Lys Phe Ser Asp 
                165                 170                 175     


Lys Gly Leu Asn Thr Gln Asp Leu Val Ala Leu Val Gly Gly His Thr 
            180                 185                 190         


Ile Gly Thr Ala Ala Cys Ser Val Phe Ser Tyr Arg Leu Tyr Asn Phe 
        195                 200                 205             


Asn Asn Thr Asn Arg Pro Asp Pro Ser Ile Asn Gln Ala Phe Leu Pro 
    210                 215                 220                 


Gln Leu Arg Ala Leu Cys Pro Asn Gly Gly Val Leu Glu Ser Asp Ala 
225                 230                 235                 240 


Lys Leu Leu Ser Asn Pro Thr Thr Gln Arg Phe Val Gln Arg Phe Ser 
                245                 250                 255     


Gly Val Arg Gly Thr Pro Asn Leu Arg Phe Asn Val Glu Phe Gly Arg 
            260                 265                 270         


Ser Met Val Lys Met Gly Asn Ile Glu Leu Lys Thr Gly Arg Gln Gly 
        275                 280                 285             


Glu Ile Arg Arg Val Cys Thr Thr Thr Asn 
    290                 295             


<210>  126
<211>  338
<212>  PRT
<213>  Artemisia annua

<400>  126

Met Thr Lys Gln Gln Arg Ser Val Cys Val Ala Ile Leu Ala Leu Ile 
1               5                   10                  15      


Ala Leu Gly Met Val Ala Gly Val Ala His Ala Ala Ile Gly Leu Pro 
            20                  25                  30          


Pro Glu Ala Ala Pro Leu Ile Arg His Phe Tyr Lys Val His Asn Thr 
        35                  40                  45              


Cys Ala Asn Val Glu Pro Phe Val Arg His Gln Val Lys Leu Val Tyr 
    50                  55                  60                  


Asp Asn Asp Arg Thr Val Ala Pro Lys Leu Ile Lys Leu Leu Tyr Ala 
65                  70                  75                  80  


Asp Cys Met Ile Asn Gly Cys Asp Ala Ser Ile Leu Leu Asp Gly Pro 
                85                  90                  95      


Asn Thr Glu Lys Glu Ser Pro Lys Thr Arg Gly Leu Gly Ala Phe Val 
            100                 105                 110         


Leu Ile Asp Lys Ile Lys Gln Val Leu Glu Ala Arg Cys Pro Gly Ala 
        115                 120                 125             


Val Ser Cys Ala Asp Ile Leu Asn Leu Ala Thr Arg Asp Ala Val Phe 
    130                 135                 140                 


Phe Ser Gly Gly Pro Ser Tyr Pro Val Phe Leu Gly Arg Arg Asp Gly 
145                 150                 155                 160 


Arg Asp Ser Asn Ala Ala Trp Val Asp Leu Pro Ser Pro Ser Ile Ser 
                165                 170                 175     


Trp Glu Ser Ser Leu Ala Tyr Phe Glu Ser Lys Gly Leu Asp Val Gln 
            180                 185                 190         


Asp Met Val Thr Leu Leu Gly Ala His Thr Met Gly Arg Val Arg Cys 
        195                 200                 205             


Ser Asn Ile Leu Asp Arg Leu Tyr Asn Phe Asn Asn Thr Gly Lys Ser 
    210                 215                 220                 


Asp Pro Ser Met Glu Ser Leu Thr Leu Arg Tyr Leu Arg Lys Gln Cys 
225                 230                 235                 240 


Pro Pro Lys Leu Lys Leu Gly Gln Pro Asn Pro Leu Ile Asn Leu Asn 
                245                 250                 255     


Pro Ser Asn Pro Thr His Arg Phe Ile Asn Ser Tyr Tyr Thr Arg Val 
            260                 265                 270         


Leu Thr Asn Lys Ser Val Leu Gly Val Asp Gln Gln Leu Arg Tyr Gly 
        275                 280                 285             


Gly Asp Thr Tyr Asp Leu Thr Asp Glu Phe Ala Ser Ser Ile Glu Asp 
    290                 295                 300                 


Phe Lys Gly Gly Phe Ala Tyr Ser Met Ser Arg Met Gly Gly Leu Lys 
305                 310                 315                 320 


Val Leu Thr Gly Thr Lys Gly Glu Ile Arg Leu Asn Cys Arg Met Val 
                325                 330                 335     


Asn Lys 
        


<210>  127
<211>  391
<212>  PRT
<213>  Artemisia annua

<400>  127

Met His Ile Phe Ile Ser Leu Phe Leu Glu Ser Tyr Thr Arg Ser Ser 
1               5                   10                  15      


Gln Lys Leu Ser His Thr Asn Glu Lys Lys His Thr Arg Ser Val Gly 
            20                  25                  30          


Arg Met Asn Asn Thr Leu Ile Val Met Cys Thr Met Ile Ile Ser Cys 
        35                  40                  45              


Cys Lys Ile Leu Ala Ile Ser Glu Thr Ser Leu Arg Val Gly Phe Tyr 
    50                  55                  60                  


Asp Glu Thr Cys Pro Asp Ala Glu Ser Ile Val Asn Gly Phe Val Lys 
65                  70                  75                  80  


Asp Ala Ala Arg Phe Asp Asn Gln Met Pro Ala Ile Leu Leu Arg Leu 
                85                  90                  95      


His Phe His Asp Cys Phe Val Gln Val Leu Ser Leu Ile Phe Phe Phe 
            100                 105                 110         


Lys Ser Thr Gln Leu Ser Trp Phe His Leu Val Leu Ile Asn Asn Ala 
        115                 120                 125             


Trp Phe Glu Phe Asp Gln Gly Cys Asp Gly Ser Ile Leu Ile Asp Asp 
    130                 135                 140                 


Asp Pro Ile Ser Glu Lys Leu Ala Glu Gly His Gln Gly Val Lys Gly 
145                 150                 155                 160 


Phe Asp Val Ile Glu Asn Ala Lys Ser Arg Leu Glu Phe Val Cys Pro 
                165                 170                 175     


Gly Val Val Ser Cys Ala Asp Ile Val Ala Ile Ala Ala Arg Asp Ala 
            180                 185                 190         


Val Ala Phe Thr Phe Gly Pro Phe Tyr Glu Val Glu Thr Gly Arg Arg 
        195                 200                 205             


Asp Gly Phe Val Ser Asn Val Ser Leu Ala Asp Asn Met Pro Asp Phe 
    210                 215                 220                 


Arg Asp Ser Ile Gln Leu Leu Lys Gln Lys Phe Phe Asp Lys Gly Leu 
225                 230                 235                 240 


Asn Glu Lys Asp Leu Val Val Leu Ser Gly Ala His Thr Ile Gly Thr 
                245                 250                 255     


Thr Ala Cys Phe Phe Leu Met Asp Arg Leu Tyr Asn Phe Val Ser Gly 
            260                 265                 270         


Gly Gly Pro Asp Pro Ser Ile Asp Pro Asp Leu Leu Pro Glu Leu Met 
        275                 280                 285             


Glu Thr Cys Pro Pro Asn Gly Asp Thr Asp Phe Arg Leu Pro Ile Asp 
    290                 295                 300                 


His Asn Ser Arg Asp Thr Phe Asp Asp Leu Ile Leu Asp Asn Ile Arg 
305                 310                 315                 320 


Ser Gly Phe Ala Val Leu Gln Ser Asp Ala Lys Leu Met Asp Asp Arg 
                325                 330                 335     


Val Thr Lys Gln Ile Leu Asp Ser Tyr Phe Gly Ser Ser Asn Gln Ser 
            340                 345                 350         


Val Gln Pro Ser Phe Glu Thr Asp Phe Val Asn Ser Met Ile Lys Met 
        355                 360                 365             


Gly Arg Ile Gly Val Lys Thr Ser Ser Lys Thr Gly Glu Ile Arg Arg 
    370                 375                 380                 


Val Cys Asn Thr Phe Asn Asp 
385                 390     


<210>  128
<211>  317
<212>  PRT
<213>  Artemisia annua

<400>  128

Met Asp Glu Phe Ser Glu Lys Thr Ile Glu Lys Ile Arg Gly Val Arg 
1               5                   10                  15      


Asp Ser Glu Ile Ala Pro Ser Arg Glu Ser Gln Leu Thr Ala Asn Phe 
            20                  25                  30          


Tyr Ala Arg Thr Cys Pro Asn Phe Arg Ser Val Ile Thr Arg Ala Val 
        35                  40                  45              


Asn Ser Ala Val Ser Ser Glu Ala Arg Met Gly Ala Ser Leu Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Gly Cys Asp Ala Ser Val Leu Leu Asp 
65                  70                  75                  80  


Thr Thr Ala Asn Phe Thr Gly Glu Lys Gly Ala Gly Pro Asn Ala Gly 
                85                  90                  95      


Ser Ile Arg Gly Phe Asn Val Ile Asp Thr Ile Lys Thr Gln Leu Glu 
            100                 105                 110         


Arg Gln Cys Ala Gly Val Val Ser Cys Ala Asp Ile Leu Ala Ala Ala 
        115                 120                 125             


Ala Arg Asp Ser Val Val Ala Leu Gly Gly Pro Gly Trp Asn Leu Val 
    130                 135                 140                 


Phe Gly Arg Arg Asp Ser Thr Thr Ala Ser Ala Asn Thr Ala Asn Ser 
145                 150                 155                 160 


Asn Leu Pro Ala Pro Thr Leu Ser Leu Ser Gly Leu Ile Ser Ser Phe 
                165                 170                 175     


Ser Asn Gln Asn Leu Asn Ala Asn Glu Leu Val Ala Leu Ser Gly Ala 
            180                 185                 190         


His Thr Ile Gly Gln Ala Arg Cys Thr Thr Phe Arg Ser Arg Leu Ala 
        195                 200                 205             


Asn Asp Asn Asn Ile Asn Ala Ser Phe Ala Thr Ser Thr Arg Ala Asn 
    210                 215                 220                 


Cys Pro Thr Ser Gly Gly Asp Asn Asn Leu Ser Pro Leu Asp Ala Thr 
225                 230                 235                 240 


Pro Thr Arg Phe Asp Asn Arg Tyr Phe Ser Asp Leu Ile Ser Gln Arg 
                245                 250                 255     


Gly Leu Leu His Ser Asp Gln Glu Leu Phe Asn Gly Gly Ser Thr Asp 
            260                 265                 270         


Ala Leu Val Arg Thr Tyr Ala Ser Asn Gln Ala Thr Phe Phe Arg Asp 
        275                 280                 285             


Phe Ala Ser Ala Met Val Lys Met Ser Asn Leu Asn Pro Leu Thr Gly 
    290                 295                 300                 


Ser Asn Gly Gln Ile Arg Thr Asn Cys Arg Arg Thr Asn 
305                 310                 315         


<210>  129
<211>  297
<212>  PRT
<213>  Artemisia annua

<400>  129

Met Ser His Asn Leu Phe Leu Leu Pro Leu Val Phe Leu Ala Leu Phe 
1               5                   10                  15      


Pro Val Val Glu Pro Arg Leu Arg Gln Arg Tyr Tyr Ser Glu Thr Cys 
            20                  25                  30          


Pro Asn Ala Glu Thr Ile Val Thr Phe Met Met Gln Lys Ala Met Ile 
        35                  40                  45              


Lys Asp Pro Arg Ser Gly Ala Ser Val Met Arg Phe Gln Phe His Asp 
    50                  55                  60                  


Cys Phe Val Asn Gly Cys Asp Ala Ser Leu Leu Leu Asp Asp Thr Pro 
65                  70                  75                  80  


Thr Met Leu Gly Glu Lys Leu Ser Leu Ser Asn Ile Asp Ser Leu Arg 
                85                  90                  95      


Ser Tyr Asp Val Ile Asp Trp Ile Lys Gly Ala Leu Glu Arg Thr Cys 
            100                 105                 110         


Pro Met Thr Val Ser Cys Ala Asp Ile Ile Ile Met Ala Ser Arg Asp 
        115                 120                 125             


Ala Val Val Leu Val Asp Leu Leu Lys Ile Leu Phe Leu Ile Phe Ser 
    130                 135                 140                 


Leu Ser Val Gln Asp Leu Val Ala Leu Ser Gly Ser His Ser Ile Gly 
145                 150                 155                 160 


Asn Ala Arg Cys Phe Ser Ile Val His Arg Ile Tyr Asn Gln Ser Asp 
                165                 170                 175     


Asp Gly Lys Pro Asp Pro Ser Ile Glu Pro Gly Phe Leu Lys Lys Leu 
            180                 185                 190         


Gln Glu Leu Cys Pro Leu Gly Gly Asp Glu Asn Val Ile Gly Asp Leu 
        195                 200                 205             


Asp Phe Thr Pro Lys Thr Phe Asp Asn Glu Tyr Phe Lys Asp Leu Val 
    210                 215                 220                 


Asn Gly Lys Gly Phe Leu Asn Ser Asp Glu Thr Leu Phe Thr Asn Pro 
225                 230                 235                 240 


Gln Thr Arg Glu Tyr Val Gln Arg Tyr Ser Glu Asp Gln Ser Ser Phe 
                245                 250                 255     


Phe Lys Asp Phe Val Glu Gly Met Lys Lys Leu Gly Asp Leu Gln Ser 
            260                 265                 270         


Gly Arg Pro Gly Glu Ile Arg Lys Asn Cys Arg Val Val Asn Asn Pro 
        275                 280                 285             


Pro Pro Val Asn Leu Met Val Arg Lys 
    290                 295         


<210>  130
<211>  258
<212>  PRT
<213>  Artemisia annua

<400>  130

Met Gln Gly Cys Asp Gly Ser Val Leu Leu Asp Ser Ser Gly Thr Ile 
1               5                   10                  15      


Asn Ser Glu Lys Arg Ser Val Pro Asn Arg Asp Ser Val Arg Gly Phe 
            20                  25                  30          


Glu Val Ile Asp Glu Ile Lys Ser Val Leu Glu Lys Ala Cys Pro Gln 
        35                  40                  45              


Thr Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Thr 
    50                  55                  60                  


Val Leu Thr Gly Gly Pro Ser Trp Asp Val Pro Leu Gly Arg Arg Asp 
65                  70                  75                  80  


Ser Leu Gly Ala Ser Leu Ser Gly Ser Asn Gln Asn Ile Pro Ala Pro 
                85                  90                  95      


Asn Asn Thr Phe Gln Thr Ile Leu Thr Lys Phe Lys Leu Lys Gly Leu 
            100                 105                 110         


Asp Ile Val Asp Phe Val Ala Leu Ser Gly Ser His Thr Ile Gly Asn 
        115                 120                 125             


Ala Arg Cys Thr Ser Phe Arg Gln Arg Leu Tyr Asn Asn Thr Gly Asn 
    130                 135                 140                 


Gly Gln Pro Asp Phe Ala Leu Asp Gln Thr Tyr Ala Ala Gln Leu Arg 
145                 150                 155                 160 


Ala Asn Cys Pro Arg Thr Gly Gly Asp Gln Asn Leu Phe Val Met Asp 
                165                 170                 175     


Pro Gly Ser Pro Thr Lys Phe Asp Asn Gly Tyr Tyr Lys Asn Leu Ile 
            180                 185                 190         


Ala Leu Lys Gly Met Leu Ser Ser Asp Glu Ile Leu Tyr Thr Gln Asn 
        195                 200                 205             


Gln Gln Thr Phe Asp Leu Val Lys Gln Tyr Ala Glu Asn Gln Glu Glu 
    210                 215                 220                 


Phe Phe Lys Gln Phe Ala Lys Ser Met Ile Lys Met Gly Asn Ile Thr 
225                 230                 235                 240 


Pro Leu Thr Gly Asn His Gly Glu Ile Arg Lys Ile Cys Arg Arg Ile 
                245                 250                 255     


Asn His 
        


<210>  131
<211>  272
<212>  PRT
<213>  Artemisia annua

<400>  131

Met Glu Gly Ser Ser Leu Thr Lys Thr Val Val Met Leu Val Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Thr Thr Leu Ala Leu Gly Gln Ser Ile Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Thr Arg Val Gly Phe Tyr Arg Ser Thr Cys Arg Asn Val 
        35                  40                  45              


Glu Ser Ile Val Gln Ser Ala Val Arg Thr Ala Val Gln Ala Asn Pro 
    50                  55                  60                  


Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe His Asp Cys Phe Val 
65                  70                  75                  80  


Asn Gly Cys Asp Ala Ser Ile Leu Ile Asn Gly Ala Ala Thr Glu Lys 
                85                  90                  95      


Ser Ala Pro Pro Asn Gly Phe Leu Arg Gly Phe Glu Val Ile Asp Ser 
            100                 105                 110         


Ala Lys Ser Gln Leu Glu Thr Thr Cys Pro Gly Val Val Ser Cys Ala 
        115                 120                 125             


Asp Ile Val Ala Leu Ala Ala Arg Asp Ser Val Val Leu Ala Gly Gly 
    130                 135                 140                 


Arg Ser Trp Pro Val Pro Leu Gly Arg Arg Asp Gly Leu Val Ser Arg 
145                 150                 155                 160 


Ala Ser Asp Thr Ala Asn Leu Pro Ala Phe Asn Asp Pro Met Thr Val 
                165                 170                 175     


Gln Ile Gln Lys Phe Ala Asp Lys Gly Leu Asn Ile Gln Asp Leu Val 
            180                 185                 190         


Ile Leu Val Gly Gly His Thr Ile Gly Thr Ala Ala Cys Ala Leu Phe 
        195                 200                 205             


Ser Tyr Arg Leu Tyr Asn Phe Ser Asn Thr Asn Ala Pro Asp Pro Asp 
    210                 215                 220                 


Ile Asn Gln Ala Phe Leu Pro Gln Leu Arg Ala Leu Cys Pro Asn Gly 
225                 230                 235                 240 


Gly Asn Gly Leu Arg Arg Val Ala Leu Asp Thr Gly Ser Val Asn Ser 
                245                 250                 255     


Phe Gly Asn Ser Phe Tyr Glu Glu Leu Glu Glu Trp Ala Gly Ser Asn 
            260                 265                 270         


<210>  132
<211>  233
<212>  PRT
<213>  Artemisia annua

<400>  132

Met Asp Val Val Asp Glu Ile Lys Glu Ala Leu Glu Arg Ile Cys Pro 
1               5                   10                  15      


Met Thr Val Ser Cys Ala Asp Ile Ile Ile Met Ala Ser Arg Asp Ala 
            20                  25                  30          


Val Ala Leu Ser Ala Gly Pro Phe Trp Glu Val Lys Leu Gly Arg Leu 
        35                  40                  45              


Asp Ser Leu Ser Ala Ser Gln Lys Ala Ser Asp Asp Ile Met Pro Ser 
    50                  55                  60                  


Pro Arg Ser Asn Ala Ser Met Leu Ile Asp Leu Phe Ala Arg Phe Asn 
65                  70                  75                  80  


Leu Ser Val Gln Asp Leu Val Ala Leu Ser Gly Ser His Ser Ile Gly 
                85                  90                  95      


Asn Ala Arg Cys Phe Ser Ile Val His Arg Ile Tyr Asn Gln Ser Asp 
            100                 105                 110         


Asp Gly Lys Pro Asp Pro Ser Ile Glu Pro Gly Phe Leu Lys Lys Leu 
        115                 120                 125             


Gln Glu Leu Cys Pro Leu Gly Gly Asp Glu Asn Val Ile Gly Asp Leu 
    130                 135                 140                 


Asp Phe Thr Pro Arg Thr Phe Asp Asn Glu Tyr Phe Lys Asp Leu Val 
145                 150                 155                 160 


Asn Gly Lys Gly Phe Leu Asn Ser Asp Glu Thr Leu Phe Thr Asn Pro 
                165                 170                 175     


Gln Thr Arg Glu Tyr Val Gln Arg Tyr Ser Glu Asp Gln Ser Ala Phe 
            180                 185                 190         


Leu Lys Asp Phe Val Glu Gly Met Ile Lys Leu Gly Asp Leu Gln Ser 
        195                 200                 205             


Gly Leu Pro Gly Glu Ile Arg Lys Asn Cys Arg Val Val Asn Ser Pro 
    210                 215                 220                 


Pro Pro Ala Asn Val Met Val Arg Lys 
225                 230             


<210>  133
<211>  384
<212>  PRT
<213>  Artemisia annua

<400>  133

Met Glu Ala Phe Lys Gly Asp Ile Leu Ile Phe Thr Thr Ile Asn Leu 
1               5                   10                  15      


Glu Thr Leu Leu Thr Ser Gln Tyr Leu Ser His Leu Ser Phe Phe Val 
            20                  25                  30          


Tyr Leu Leu Glu Ser Asn Met Ala Ile Gln Lys Gln Leu Ile Val Val 
        35                  40                  45              


Leu Gln Leu Leu Leu Ile Ala Leu Val Leu Lys Ile Ala Asn Gly Lys 
    50                  55                  60                  


Gly Leu Glu Leu Gly Phe Tyr Lys Asn Thr Cys Pro Arg Val Glu Ala 
65                  70                  75                  80  


Ile Val Arg Lys Thr Thr Ala Asn Tyr Ile His Arg Ala Pro Ser Leu 
                85                  90                  95      


Ala Ala Gly Leu Leu Arg Met His Phe His Asp Cys Phe Val Arg Gly 
            100                 105                 110         


Cys Asp Gly Ser Val Leu Leu Asn Ser Thr Thr Asn Asn Gln Ala Glu 
        115                 120                 125             


Lys Glu Gly Ile Pro Asn Leu Thr Leu Arg Gly Phe Gln Val Ile Asp 
    130                 135                 140                 


Ala Ala Lys Thr Ala Leu Glu Ala Ala Cys Pro Gly Val Val Ser Cys 
145                 150                 155                 160 


Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ala Ile Tyr Gln Gly Cys 
                165                 170                 175     


Asp Gly Ser Val Leu Leu Asn Ser Thr Ala Asn Asn Gln Ala Glu Lys 
            180                 185                 190         


Glu Gly Ile Pro Asn Leu Thr Leu Arg Gly Phe Gln Val Ile Asp Ala 
        195                 200                 205             


Ala Lys Thr Ala Leu Glu Ala Ala Cys Pro Gly Val Val Ser Cys Ala 
    210                 215                 220                 


Asp Ile Leu Ala Leu Ala Ala Arg Asp Ala Ile Tyr Gln Ile Lys Gly 
225                 230                 235                 240 


Pro Phe Trp Pro Val Pro Leu Gly Arg Arg Asp Gly His Thr Val Gly 
                245                 250                 255     


Val Ser His Cys Pro Val Ile Val Asn Arg Leu Tyr Asn Phe Thr Gly 
            260                 265                 270         


Lys Gly Asp Thr Asp Pro Ser Leu Asp Pro Lys Phe Ile Pro Gln Leu 
        275                 280                 285             


Lys Ser Ile Cys Ser Pro Thr Asp Thr Thr Thr Val Leu Ala Met Asp 
    290                 295                 300                 


Arg Thr Pro Arg Ser Phe Asp Glu Asp Tyr Tyr Thr Val Val Leu Arg 
305                 310                 315                 320 


Lys Arg Gly Leu Phe Gln Ser Asp Ala Ala Leu Leu Asn Asp Lys Gln 
                325                 330                 335     


Thr Ser Ala Tyr Val Lys Leu Gln Ser Lys Ser Phe Gly Tyr Thr Phe 
            340                 345                 350         


Phe Asn Asp Phe Ser Lys Ser Met Val Lys Met Gly Lys Ile Gly Val 
        355                 360                 365             


Leu Thr Gly Phe Ala Gly Glu Ile Arg Arg Thr Cys Ala Leu Val Asn 
    370                 375                 380                 


<210>  134
<211>  290
<212>  PRT
<213>  Artemisia annua

<400>  134

Met Gln Lys Met Asn Ile Ile Cys Phe Leu Ser Leu Phe Val Leu Phe 
1               5                   10                  15      


Met Phe Gln Ile Ala Thr Pro Ser Ser Asp Asp Tyr Gly Leu Ser Thr 
            20                  25                  30          


Glu Tyr Tyr Asn Arg Val Cys Pro Gln Ala Leu Pro Thr Ile Lys Arg 
        35                  40                  45              


Val Val Glu Asp Ala Val Ala Gln Glu Arg Arg Met Gly Ala Ser Leu 
    50                  55                  60                  


Leu Arg Leu His Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Asp Gln Thr Ser Thr Ile Asp Ser Glu Lys Asn Ala Gly 
                85                  90                  95      


Ala Asn Leu Asn Ser Ala Arg Gly Phe Glu Leu Gly Gly Pro Ser Trp 
            100                 105                 110         


Glu Val Lys Leu Gly Arg Arg Asp Ser Thr Thr Ala Ser Arg Thr Thr 
        115                 120                 125             


Ala Asn Ala Asn Leu Pro Ser Pro Phe Met Asp Leu Pro Ala Leu Ile 
    130                 135                 140                 


Lys Asn Phe Lys Asp Gln Gly Leu Asp Glu Lys Asp Leu Val Leu Leu 
145                 150                 155                 160 


Ser Gly Ala His Thr Ile Gly Phe Ala Gln Cys Phe Thr Phe Arg Asp 
                165                 170                 175     


His Ile Tyr Asn Asp Thr Asn Ile Asp Pro Ala Phe Ala Gly His Leu 
            180                 185                 190         


Arg Ser Ile Cys Pro Arg Val Gly Asp Asp Ser Asn Leu Ala Pro Leu 
        195                 200                 205             


Asp Pro Thr Pro Ser Ser Phe Asp Thr Lys Tyr Phe Asn Asn Leu Met 
    210                 215                 220                 


Lys Lys Arg Gly Leu Leu Lys Thr Asp Gln Val Leu Phe Ser Lys Gly 
225                 230                 235                 240 


Glu Thr Gly Glu Leu Val Ser Glu Tyr Asn Glu Asp Gln Thr Lys Phe 
                245                 250                 255     


Phe Glu Asp Phe Ala Lys Ser Met Ile Lys Met Gly Asn Ile Asn Leu 
            260                 265                 270         


Leu Thr Gly Asn Arg Gly Glu Val Arg Asp Asn Cys Arg Arg Val Asn 
        275                 280                 285             


Ser Gln 
    290 


<210>  135
<211>  324
<212>  PRT
<213>  Artemisia annua

<400>  135

Met Ala Thr His Lys Gln Ile Ser Asn Ile Cys Leu Ala Phe Ile Leu 
1               5                   10                  15      


Phe Phe His Phe Tyr Thr Gly Thr Cys Glu Val Gln Leu Asn Tyr Tyr 
            20                  25                  30          


Ser Lys Ser Cys Pro Asn Ala Glu Glu Ile Val Lys Gln Gln Val Ile 
        35                  40                  45              


Ala Leu Tyr His Lys His Gly Asn Thr Ala Val Ser Trp Ile Arg Thr 
    50                  55                  60                  


Leu Phe His Asp Cys Met Val Lys Ser Cys Asp Ala Ser Ile Leu Leu 
65                  70                  75                  80  


Glu Ser Ile Asn Gly Ile Ile Ser Glu Lys Thr Ser Lys Gln Asn Met 
                85                  90                  95      


Gly Met Arg Asn Phe Lys Tyr Ile Asn Thr Ile Lys Asp Ala Leu Glu 
            100                 105                 110         


Glu Ala Cys Pro Met Thr Val Ser Cys Ala Asp Ile Val Ala Leu Ser 
        115                 120                 125             


Ala Arg Asp Gly Val Val Met Leu Gly Gly Pro His Met Glu Met Lys 
    130                 135                 140                 


Thr Gly Arg Lys Asp Ser Lys Glu Ser His Leu Ala Glu Ile Asp Ala 
145                 150                 155                 160 


Leu Leu Pro Asn His Asn Asp Ser Met Thr Phe Val Leu Ser Arg Phe 
                165                 170                 175     


Gln Ser Val Gly Ile Asp Ala Glu Gly Thr Val Ala Leu Leu Gly Ala 
            180                 185                 190         


His Ser Val Gly Arg Val His Cys Val Asn Leu Val Asp Arg Leu Tyr 
        195                 200                 205             


Pro Asp Val Asp Pro Thr Leu Asp Pro Asp Tyr Ala Glu Tyr Leu Lys 
    210                 215                 220                 


Arg Arg Cys Pro His Pro Glu Pro Asn Pro Arg Asp Val Glu Tyr Ser 
225                 230                 235                 240 


Arg Thr Asp Leu Ile Thr Pro Met Thr Leu Asp Asn Met Tyr Tyr Lys 
                245                 250                 255     


Asn Leu Ile Asn Asn Arg Gly Leu Leu Ile Val Asp Gln Gln Leu Leu 
            260                 265                 270         


Ser Asn Pro Ile Thr Ser Pro Tyr Val Lys Lys Met Ala Ala Asp Asn 
        275                 280                 285             


Asp Tyr Phe His Glu Gln Phe Ser Lys Ala Leu Leu Ile Leu Ser Glu 
    290                 295                 300                 


Asn Asn Pro Ile Asn Glu Asp Val Gly Glu Val Arg Lys Asp Cys Arg 
305                 310                 315                 320 


Phe Val Asn Lys 
                


<210>  136
<211>  271
<212>  PRT
<213>  Artemisia annua

<400>  136

Met Lys Val Ser Ser Phe Asn Lys Met Gly Ile Leu Leu Ile Ile Leu 
1               5                   10                  15      


Leu Ala Ala Met Thr Asn Ile Ala Gln Gly Gln Gly Thr Gln Val Gly 
            20                  25                  30          


Phe Tyr Arg Thr Thr Cys Pro Arg Val Glu Ser Ile Val Gln Ser Ala 
        35                  40                  45              


Val Arg Gln Ala Val Arg Ser Asn Pro Thr Met Ala Pro Gly Leu Leu 
    50                  55                  60                  


Arg Ile Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Leu 
65                  70                  75                  80  


Leu Leu Asn Gly Ser Ser Ser Glu Lys Thr Ala Arg Pro Asn Leu Pro 
                85                  90                  95      


Leu Arg Gly Phe Gln Val Ile Asp Ala Ala Lys Ala Gln Leu Glu Arg 
            100                 105                 110         


Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Val Ala Leu Ala Ala 
        115                 120                 125             


Arg Asp Ser Val Val Leu Thr Gly Gly Thr Ser Trp Gln Val Pro Leu 
    130                 135                 140                 


Gly Arg Arg Asp Gly Phe Val Ser Arg Ala Ser Asp Thr Thr Asn Leu 
145                 150                 155                 160 


Pro Ala Phe Asn Asp Pro Ile Thr Val Gln Ile Arg Lys Phe Ser Asp 
                165                 170                 175     


Lys Gly Leu Asn Thr Gln Asp Leu Val Ala Leu Val Gly Gly His Thr 
            180                 185                 190         


Ile Gly Thr Ala Ala Cys Ser Val Phe Ser Tyr Arg Leu Tyr Asn Phe 
        195                 200                 205             


Asn Asn Thr Asn Arg Pro Asp Pro Ser Ile Asn Gln Ala Phe Leu Pro 
    210                 215                 220                 


Gln Leu Arg Ala Leu Cys Pro Asn Gly Gly Thr Thr Thr Thr Asn Arg 
225                 230                 235                 240 


Arg Arg Val Trp Val His His Arg Met Gly Gly Leu Thr Ile Pro Cys 
                245                 250                 255     


Ser Glu Asp Lys Phe Thr Asn Leu Ala Cys Ser Leu Gly Thr Leu 
            260                 265                 270     


<210>  137
<211>  281
<212>  PRT
<213>  Artemisia annua

<400>  137

Met Asn Asn Ser Val Leu Phe Asn His Asn Tyr Asn Gly Phe His Phe 
1               5                   10                  15      


Cys Val Asp Asp Leu Met Leu Asn Ser Gln Gly Cys Asp Gly Ser Ile 
            20                  25                  30          


Leu Ile Asp Asn Gly Glu Asp Ser Glu Arg Lys Ala Asn Gly His Gln 
        35                  40                  45              


Gly Val Gln Gly Tyr Asn Val Ile Glu Asn Ala Lys Ala Gln Leu Glu 
    50                  55                  60                  


Ile Met Cys Pro Ser Val Val Ser Cys Ala Asp Ile Val Ala Met Ala 
65                  70                  75                  80  


Ala Arg Asp Ala Val Asp Leu Ser His Gly Pro Val Tyr Gln Val Glu 
                85                  90                  95      


Thr Gly Arg Lys Asp Gly Leu Val Ser Arg Met Glu Leu Ala Ala Arg 
            100                 105                 110         


Met Pro Asp Val Gln Asp Ser Ile His Ile Leu Lys Gln Lys Phe Ile 
        115                 120                 125             


Glu Lys Gly Leu Asn Asp Arg Asp Leu Val Ile Leu Ser Ala Ala His 
    130                 135                 140                 


Thr Ile Gly Thr Ser Ala Cys Phe Phe Met Thr Arg Arg Leu Tyr Asp 
145                 150                 155                 160 


Phe Ala Ser Ser Gly Gly Pro Asp Pro Ser Ile Asn Pro Ser Phe Leu 
                165                 170                 175     


Pro Glu Leu Met Ser Ser Cys Pro Lys Arg Gly Asn Pro Asn Asp Arg 
            180                 185                 190         


Leu Pro Met Asp His Gly Ser Gly Asp Ile Phe Asp Lys Gln Ile Phe 
        195                 200                 205             


Gln Asn Ile Arg Ser Gly Phe Ala Val Leu Gln Ser Asp Ala Lys Leu 
    210                 215                 220                 


Met Asp Asp Pro Thr Ile Lys Gly Ile Val Asp Ser Tyr Phe Gly Leu 
225                 230                 235                 240 


Leu Ser Pro Leu Thr Gly Pro Ser Phe Glu Gly Asp Phe Met Ser Ser 
                245                 250                 255     


Met Val Arg Met Gly Arg Ile Gly Val Lys Thr Gly Ser Ser Gly Asp 
            260                 265                 270         


Ile Arg Arg Val Cys Asn Ala Phe Asn 
        275                 280     


<210>  138
<211>  277
<212>  PRT
<213>  Artemisia annua

<400>  138

Met Ala Ser Arg Asn Val Ser Thr Thr Val Phe Phe Leu Leu Phe Leu 
1               5                   10                  15      


Ala Val Thr Asn Asn Thr Leu Cys Glu Ala Gln Leu Ser Met Thr Phe 
            20                  25                  30          


Tyr Asp Arg Thr Cys Pro Asn Ala Leu Ser Thr Ile Arg Thr Ser Ile 
        35                  40                  45              


Arg Thr Ala Ile Ser Arg Glu Arg Arg Met Val Ala Ser Ile Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser Ile Leu 
65                  70                  75                  80  


Leu Asp Asp Gly Pro Thr Ile Ile Ser Glu Lys Asn Ala Leu Pro Asn 
                85                  90                  95      


Lys Gly Ser Val Arg Asp Tyr Glu Val Ile Glu Ala Ala Lys Thr Glu 
            100                 105                 110         


Val Glu Lys Leu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Thr 
        115                 120                 125             


Val Ala Ala Arg Asp Ala Ser Glu Met Val Gly Gly Pro Ser Trp Ser 
    130                 135                 140                 


Val Lys Leu Gly Arg Arg Asp Ser Asp Thr Ala Ser Leu Val Leu Ala 
145                 150                 155                 160 


Glu Thr Gly Ala Leu Pro Ser Phe Lys Ala Pro Leu Asp Ser Leu Ile 
                165                 170                 175     


Ser Thr Phe Arg Asp Asn Gly Leu Ser Ala Arg Asp Met Val Ala Leu 
            180                 185                 190         


Ser Ala Ala Leu Glu Leu Val Thr Pro Asn Ser Phe Asp Asn Asn Tyr 
        195                 200                 205             


Phe Lys Asn Leu Leu Gln Lys Lys Gly Leu Leu Glu Thr Asp Gln Val 
    210                 215                 220                 


Leu Phe Ser Gly Gly Ser Thr Asp Ser Ile Val Thr Glu Tyr Ser Lys 
225                 230                 235                 240 


Ser Pro Ser Lys Phe Lys Ser Asp Phe Ala Ala Ala Met Val Lys Met 
                245                 250                 255     


Gly Glu Ile Arg Thr Leu Thr Gly Gln Gln Gly Val Ile Arg Arg Ile 
            260                 265                 270         


Cys Gly Ala Leu Pro 
        275         


<210>  139
<211>  489
<212>  PRT
<213>  Artemisia annua

<400>  139

Met Glu Asn Val Arg Val Phe Leu Pro Pro Arg Arg Val His Gly Trp 
1               5                   10                  15      


Phe Lys Ser Cys Lys Ser Glu Val Gln Leu Asn Tyr Tyr Ser Lys Ser 
            20                  25                  30          


Cys Pro Asn Ala Glu Glu Ile Val Lys Gln Gln Val Ile Ala Leu Tyr 
        35                  40                  45              


His Lys His Gly Asn Thr Ala Val Ser Trp Ile Arg Thr Leu Phe His 
    50                  55                  60                  


Asp Cys Met Val Lys Ser Cys Asp Ala Ser Ile Leu Leu Glu Ser Ile 
65                  70                  75                  80  


Asn Gly Ile Ile Ser Glu Lys Thr Ser Lys Gln Asn Met Gly Met Arg 
                85                  90                  95      


Asn Phe Lys Tyr Ile Asn Thr Ile Lys Asp Ala Leu Glu Glu Ala Cys 
            100                 105                 110         


Pro Met Thr Val Ser Cys Ala Asp Ile Val Ala Leu Ser Ala Arg Asp 
        115                 120                 125             


Gly Val Val Met Leu Gly Gly Pro His Met Glu Met Lys Thr Gly Arg 
    130                 135                 140                 


Lys Asp Ser Lys Glu Ser His Leu Ala Glu Ile Asp Ala Leu Leu Pro 
145                 150                 155                 160 


Asn His Asn Asp Ser Met Thr Phe Val Leu Ser Arg Phe Gln Ser Val 
                165                 170                 175     


Gly Ile Asp Ala Glu Gly Thr Val Ala Leu Leu Gly Ala His Ser Val 
            180                 185                 190         


Gly Arg Val His Cys Val Asn Leu Val Asp Arg Leu Tyr Pro Asp Val 
        195                 200                 205             


Asp Pro Thr Leu Asp Pro Asp Tyr Ala Glu Tyr Leu Lys Arg Arg Cys 
    210                 215                 220                 


Pro His Pro Glu Pro Asn Pro Arg Asp Val Glu Tyr Ser Arg Thr Asp 
225                 230                 235                 240 


Leu Ile Thr Pro Met Thr Leu Asp Asn Met Tyr Tyr Lys Asn Leu Ile 
                245                 250                 255     


Asn Asn Arg Gly Leu Leu Ile Val Asp Gln Gln Leu Leu Ser Asn Pro 
            260                 265                 270         


Ile Thr Ser Pro Tyr Val Lys Lys Met Ala Ala Asp Asn Asp Tyr Phe 
        275                 280                 285             


His Glu Gln Phe Ser Lys Ala Leu Leu Ile Leu Ser Glu Asn Asn Pro 
    290                 295                 300                 


Ile Asn Glu Asp Val Gly Glu Val Arg Lys Asp Cys Arg Phe Val Asn 
305                 310                 315                 320 


Lys Ser Leu Asn His Lys Ala Phe Cys Phe Leu Lys Ser Arg Asp Val 
                325                 330                 335     


Met Cys Tyr Ser Gly Ala Thr Arg Arg Ser Leu Asn His Lys Ala Phe 
            340                 345                 350         


Cys Phe Leu Lys Ser Arg Asp Val Met Cys Tyr Ser Gly Ala Thr Arg 
        355                 360                 365             


Arg Ser Leu Asn His Lys Ala Phe Cys Phe Leu Lys Ser Arg Asp Val 
    370                 375                 380                 


Met Cys Tyr Ser Gly Ala Thr Arg Arg Ser Leu Asn His Lys Ala Phe 
385                 390                 395                 400 


Cys Phe Leu Lys Ser Arg Asp Val Met Cys Tyr Ser Gly Ala Thr Arg 
                405                 410                 415     


Arg Ser Leu Asn His Lys Ala Phe Cys Phe Leu Lys Ser Arg Asp Val 
            420                 425                 430         


Met Cys Tyr Ser Gly Ala Thr Arg Arg Ser Leu Asn His Lys Ala Phe 
        435                 440                 445             


Cys Phe Leu Lys Ser Arg Asp Val Met Cys Tyr Ser Gly Ala Thr Arg 
    450                 455                 460                 


Arg Ser Leu Asn His Lys Ala Phe Cys Phe Leu Lys Ser Arg Asp Val 
465                 470                 475                 480 


Met Cys Tyr Ser Gly Ala Thr Arg Arg 
                485                 


<210>  140
<211>  332
<212>  PRT
<213>  Artemisia annua

<400>  140

Met Ala Leu Lys His Leu Ile Phe Phe Thr Leu Leu Ser Ile Leu Ala 
1               5                   10                  15      


Ile Ser Ser Phe Ala Asp Thr Glu Ser Ser Thr Thr Thr Asp Ser Gly 
            20                  25                  30          


Leu Val Leu Asn Phe Tyr Lys Asp Ser Cys Pro Gln Ala Glu Asp Ile 
        35                  40                  45              


Ile Arg Glu Gln Val Gly Leu Leu Tyr Lys Arg His Lys Asn Thr Ala 
    50                  55                  60                  


Phe Ser Trp Leu Arg Asn Ile Phe His Asp Cys Ala Val Glu Arg Cys 
65                  70                  75                  80  


Asp Ala Ser Leu Leu Leu Asp Ser Thr Arg Arg Gln Leu Ser Glu Lys 
                85                  90                  95      


Glu Thr Asp Arg Ser Phe Gly Leu Arg Asn Phe Arg Tyr Leu Glu Glu 
            100                 105                 110         


Ile Lys Glu Ala Val Glu Arg Glu Cys Pro Gly Val Val Ser Cys Ala 
        115                 120                 125             


Asp Ile Leu Val Leu Ser Gly Arg Asp Gly Ile Val Ala Val Gly Gly 
    130                 135                 140                 


Pro Tyr Ile Pro Leu Lys Thr Gly Arg Arg Asp Gly Arg Lys Ser Arg 
145                 150                 155                 160 


Ala Asp Ile Leu Glu Gln Tyr Leu Pro Asp His Asn Glu Ser Met Thr 
                165                 170                 175     


Val Val Leu Glu Arg Phe Lys Ser Ile Gly Ile Asp Thr Pro Gly Val 
            180                 185                 190         


Val Ala Leu Leu Gly Ser His Ser Val Gly Arg Thr His Cys Val Lys 
        195                 200                 205             


Leu Val His Arg Leu Tyr Pro Glu Val Asp Pro Ala Pro Asn Pro Gly 
    210                 215                 220                 


His Val Glu His Met Leu His Lys Cys Pro Asp Ala Ile Pro Asp Pro 
225                 230                 235                 240 


Lys Ala Val Gln Tyr Val Arg Asn Asp Arg Gly Thr Pro Met Lys Leu 
                245                 250                 255     


Asp Asn Asn Tyr Tyr Arg Asn Ile Leu Asp Asn Lys Gly Leu Leu Leu 
            260                 265                 270         


Val Asp Tyr Gln Leu Ala Val Asp Lys Arg Thr Lys Pro Tyr Val Lys 
        275                 280                 285             


Lys Met Ala Lys Asn Gln Asp Tyr Phe Phe Lys Gln Phe Ala Arg Ala 
    290                 295                 300                 


Ile Thr Ile Leu Thr Glu Asn Asn Pro Leu Thr Gly Asn Glu Gly Glu 
305                 310                 315                 320 


Ile Arg Gln Gln Cys Asn Val Ala Asn Lys His His 
                325                 330         


<210>  141
<211>  554
<212>  PRT
<213>  Artemisia annua

<400>  141

Met Leu Gly Trp Val Val Phe Arg Leu Val Glu Ser Cys Asn Lys Gly 
1               5                   10                  15      


Phe Tyr Lys Gly Leu Ser Leu Ala Asp Ser Gly Leu Asn Val Ser Leu 
            20                  25                  30          


Leu Gln Phe Ala Asp Asp Ala Leu Phe Phe Gly Gly Trp Ser Arg Leu 
        35                  40                  45              


Asn Ala Lys Asn Leu Ile His Ile Leu Lys Cys Phe Glu Leu Ala Ser 
    50                  55                  60                  


Gly Leu Lys Val Asn Ile Thr Lys Ser Arg Leu Met Gly Val Gly Val 
65                  70                  75                  80  


Ser Asn Val Asp Ile Ala Val Val Ala Ser Ser Leu Gly Cys Thr His 
                85                  90                  95      


Asp Ser Leu Pro Phe Thr Tyr Pro Gly Leu Pro Val Gly Arg Lys Met 
            100                 105                 110         


Arg Gly Cys Lys Ser Trp Thr Glu Val Ile Asn Arg Phe Arg Glu Arg 
        115                 120                 125             


Leu Ser Ser Trp Lys Ala Lys Ser Leu Leu Ala Gly Cys Arg Leu Thr 
    130                 135                 140                 


Leu Ile Lys Ser Ile Leu Gly Ser Leu Pro Met Tyr Tyr Leu Ser Leu 
145                 150                 155                 160 


Phe Lys Ala Pro Ala Lys Asp Ser Asn Arg Gly Ile Ser Trp Val Lys 
                165                 170                 175     


Trp Lys Ser Ile Leu Leu Asp Lys Asp Ile Gly Gly Leu Gly Val Glu 
            180                 185                 190         


Cys Leu Gln Ala Lys Asn Leu Gly Leu Leu Gly Lys Trp Lys Trp Arg 
        195                 200                 205             


Phe Leu Thr Glu Asp Lys Ala Leu Trp Arg Ile Val Ile Lys Glu Phe 
    210                 215                 220                 


Tyr Gly Glu Asp Gly Gly Phe Asn Ser Ser Leu Asn Arg Ile Ala Ser 
225                 230                 235                 240 


Gly Ala Leu Val Val Leu Ser Gln Thr Arg Pro Ser Leu Cys Tyr Asn 
                245                 250                 255     


Glu Pro Leu Val Leu Gly Tyr Tyr Glu Glu Thr Cys Gln Leu Leu Glu 
            260                 265                 270         


Lys Ile Val Arg Arg Gln Val Ala Ile Ala Val Tyr Lys Glu Pro Arg 
        275                 280                 285             


Met Ala Ala Ser Leu Leu Arg Leu His Phe His Asp Cys Phe Val Met 
    290                 295                 300                 


Gly Cys Asp Ala Ser Val Leu Leu Asp Asp Phe Glu Gly Val Gln Ser 
305                 310                 315                 320 


Glu Lys Asn Ala Gly Pro Asn Leu Asn Ser Leu Arg Gly Phe Glu Val 
                325                 330                 335     


Ile Asp Glu Ile Lys Tyr Leu Val Glu Glu Ala Cys Pro Cys Thr Val 
            340                 345                 350         


Ser Cys Ala Asp Leu Leu Ala Ile Val Ala Arg Asp Ala Val Ala Leu 
        355                 360                 365             


Arg Gly Gly Pro Lys Trp Asn Val Tyr Leu Gly Arg Lys Asp Ser Met 
    370                 375                 380                 


Lys Ala Ser Leu Asp Gly Ala Asn Gln Leu Ile Pro Ala Pro Asn Ser 
385                 390                 395                 400 


Ser Leu Glu Thr Leu Ile Ala Asn Phe Arg Tyr Gln Gly Ser His Thr 
                405                 410                 415     


Ile Gly Lys Ala Gln Cys Lys Ser Phe Arg Gln Arg Ile Tyr Asp Tyr 
            420                 425                 430         


Asp Asp Ser Glu Lys Asn Ser Tyr His His His Arg Asn Asp Asn Glu 
        435                 440                 445             


Phe Gln Arg Val Leu Lys Ser Ile Cys Pro Lys Ser Gly Lys Asp Asn 
    450                 455                 460                 


Ala Leu Ala Pro Leu Asp Ile Ala Thr Pro Leu Arg Phe Asp Asn His 
465                 470                 475                 480 


Tyr Phe Gln Asn Ile Lys Gln Gly Leu Gly Leu Leu Ile Ser Asp Asn 
                485                 490                 495     


Val Leu Ile Ser Glu Asp Ile Glu Gly Glu Ile Arg Asp Leu Val Trp 
            500                 505                 510         


Glu Phe Ala Ser Asp Glu Lys Lys Phe Phe Gly Met Phe Ala Asp Ser 
        515                 520                 525             


Leu Ile Lys Met Gly Asn Ile Arg Val Leu Thr Gly Gln Gln Gly Glu 
    530                 535                 540                 


Ile Arg Lys Asn Cys Arg Phe Ile Asn Thr 
545                 550                 


<210>  142
<211>  273
<212>  PRT
<213>  Artemisia annua

<400>  142

Met Leu Val Leu Leu Leu Ala Thr Leu Thr Thr Leu Ala Leu Gly Gln 
1               5                   10                  15      


Ser Ile Arg Gly Gly Gly Gly Gly Thr Arg Val Gly Phe Tyr Arg Ser 
            20                  25                  30          


Thr Cys Arg Asn Val Glu Ser Ile Val Gln Ser Ala Val Arg Thr Ala 
        35                  40                  45              


Val Gln Ala Asn Pro Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe 
    50                  55                  60                  


His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu Ile Asn Gly 
65                  70                  75                  80  


Ala Ala Thr Glu Lys Ser Ala Pro Pro Asn Gly Phe Leu Arg Gly Phe 
                85                  90                  95      


Glu Val Ile Asp Ala Ala Lys Ser Gln Leu Glu Thr Thr Cys Pro Gly 
            100                 105                 110         


Val Val Ser Cys Ala Asp Ile Val Ala Leu Ala Ala Arg Asp Ser Val 
        115                 120                 125             


Val Leu Ala Gly Gly Arg Ser Trp Pro Val Pro Leu Gly Arg Arg Asp 
    130                 135                 140                 


Gly Leu Val Ser Arg Ala Ser Asp Thr Ala Asn Leu Pro Ala Phe Asn 
145                 150                 155                 160 


Asp Pro Met Thr Val Gln Ile Gln Lys Phe Ala Asp Lys Gly Leu Asn 
                165                 170                 175     


Ile Gln Asp Leu Val Ile Leu Val Gly Lys Arg Val Ala Leu Asp Thr 
            180                 185                 190         


Gly Ser Val Asn Ser Phe Gly Asn Ser Phe Tyr Asp Asn Leu Arg Asn 
        195                 200                 205             


Gly Arg Gly Val Ile Glu Ser Asp Ala Lys Leu Trp Ser Asp Arg Arg 
    210                 215                 220                 


Thr Gln Arg Phe Val Gln Gly Phe Leu Gly Gly Arg Ser Gly Ser Arg 
225                 230                 235                 240 


Phe Asn Ala Glu Phe Gly Arg Ala Met Ile Lys Met Gly Asn Ile Glu 
                245                 250                 255     


Val Lys Thr Gly Thr Gln Gly Glu Ile Arg Arg Val Cys Thr Ala Thr 
            260                 265                 270         


Asn 
    


<210>  143
<211>  726
<212>  PRT
<213>  Artemisia annua

<400>  143

Met Glu Asp Asn Thr Asn Glu Ile Ile Asn Arg Ser Glu Tyr Gly Gly 
1               5                   10                  15      


Ser Ile Pro Val Asp Asn Val Gln Ala Leu Ala Ser Ser Lys Asp Leu 
            20                  25                  30          


Lys Asp Ile Pro Ser His Tyr Ile Arg Pro Glu Ile Glu Leu Asp Val 
        35                  40                  45              


Val Leu Thr Asp Glu Ser Leu Gln Ile Pro Val Ile Asp Ile Ser Lys 
    50                  55                  60                  


Leu Ala Val Ala Gly Gln Pro Gly Tyr Asp Asp Glu Leu Glu Asn Leu 
65                  70                  75                  80  


His Val Ala Cys Arg Asp Trp Gly Phe Phe Gln Ile Tyr Ile Leu Tyr 
                85                  90                  95      


Leu Phe Ser Asp Ser Ile Thr Met Asn Asn Ile Val Thr Leu Leu Val 
            100                 105                 110         


Ala Leu Leu Val Ile Ser Gln Thr Lys Thr Ser Leu Cys Asp Asn Glu 
        115                 120                 125             


Pro Leu Val Leu Gly Tyr Tyr Glu Glu Thr Cys Pro Leu Leu Glu Glu 
    130                 135                 140                 


Ile Val Gln Arg Gln Val Glu Ile Ala Val His Lys Glu Pro Arg Met 
145                 150                 155                 160 


Ala Ala Ser Leu Leu Arg Leu Asn Phe His Asp Cys Phe Val Met Gly 
                165                 170                 175     


Cys Asn Ala Ser Val Leu Leu Asp Asp Phe Glu Gly Val Gln Ser Glu 
            180                 185                 190         


Lys Asn Ala Gly Pro Asn Leu Asn Ser Leu Arg Gly Phe Glu Val Ile 
        195                 200                 205             


Asp Glu Ile Lys Tyr Leu Val Glu Glu Ala Cys Pro Cys Thr Val Ser 
    210                 215                 220                 


Cys Ala Asp Leu Leu Ala Ile Val Ala Arg Asp Ala Val Ala Leu Arg 
225                 230                 235                 240 


Gly Gly Pro Lys Trp Asn Val Tyr Leu Gly Arg Lys Asp Ser Met Lys 
                245                 250                 255     


Ala Ser Leu Asp Gly Ala Asn Gln Leu Ile Pro Ala Pro Asn Ser Ser 
            260                 265                 270         


Leu Glu Thr Leu Ile Ala Asn Phe Arg Tyr Gln Gly Leu Asn Ile Gln 
        275                 280                 285             


Asp Leu Val Ala Leu Ser Gly Ser His Thr Ile Gly Lys Ala Gln Cys 
    290                 295                 300                 


Lys Ser Phe Arg Gln Arg Ile Tyr Asp Tyr Asp Asp Ser Glu Lys Asn 
305                 310                 315                 320 


Ser Tyr His His His His Asn Asp Asn Glu Phe Gln Arg Val Leu Lys 
                325                 330                 335     


Ser Ile Cys Pro Lys Ser Gly Lys Asp Asn Ala Leu Ala Pro Leu Asp 
            340                 345                 350         


Ile Ala Thr Pro Leu Arg Phe Asp Asn His Tyr Phe Gln Asn Ile Lys 
        355                 360                 365             


Gln Gly Leu Gly Leu Leu Ile Ser Asp Asn Val Leu Ile Ser Glu Asp 
    370                 375                 380                 


Ile Glu Gly Glu Ile Arg Asp Leu Val Trp Glu Phe Ala Ser Asp Glu 
385                 390                 395                 400 


Lys Lys Met Ile Pro Gly Thr Asn Leu His Gln Phe Asp Val His Asn 
                405                 410                 415     


Asp Gly Phe Phe Ala His Leu Pro Leu Arg Tyr Asp Asp Gly Val Ile 
            420                 425                 430         


Leu Asn Met Ala Ser Val Arg Met Pro Tyr Glu Lys Phe Ala Glu Phe 
        435                 440                 445             


Leu Glu Glu Lys Val Gly Asn Tyr Phe Gln Gly Leu Tyr Tyr Lys Val 
    450                 455                 460                 


Pro Asn Val Glu Leu Glu Lys Gly Leu Val Lys Val Ser Asp Asp Lys 
465                 470                 475                 480 


Gln Ile Ala His Met Phe Asp Val Ala Glu Leu Tyr Gly Arg Leu Asp 
                485                 490                 495     


Leu Tyr Leu Asp His Leu Asp Met Asp Leu Ser Glu Tyr Leu Glu Lys 
            500                 505                 510         


Ala Asp Thr Asp Asp Met Asp Glu Cys Val Tyr Arg Ala Lys Gly Pro 
        515                 520                 525             


Pro Lys Pro Arg Tyr Cys Asn Lys Phe Ser Val Asp Glu Met Val Asn 
    530                 535                 540                 


Trp Ala Glu Met Glu Val Glu Tyr Glu Ala Ser Ser Ser Asn His Pro 
545                 550                 555                 560 


Arg Thr Ser Ala Glu Gly Asp Val Pro Arg Ala Ser Glu Asn Val Glu 
                565                 570                 575     


Val Pro Met Thr Ser Ser Glu Val Asp Val Ala Thr Thr Arg Val Asp 
            580                 585                 590         


Gly Tyr Asn Val Arg Lys Glu Leu Ile Glu Leu Arg Lys Arg Ile Lys 
        595                 600                 605             


Ala Ser Arg Leu Lys Glu Pro Glu Ser Val Thr Glu Met Asn Glu Pro 
    610                 615                 620                 


Asn Asp Gln Asn Gln Ile His Thr Glu Asn Thr Asp Ser His Arg Ser 
625                 630                 635                 640 


Glu Thr Met Ile Glu His Asp Leu Phe Met Asn Thr Leu Met Arg Arg 
                645                 650                 655     


Leu Gln Ser Ser Asp Glu Asn Gly Met His Gln Asp Pro Phe Val Cys 
            660                 665                 670         


Val Glu Lys His Val Asp Arg Tyr Pro Val Tyr Asp Glu Ser Thr His 
        675                 680                 685             


Trp Arg Leu Arg His Pro Lys Lys Asn Met Leu Thr Gly Thr Gln Leu 
    690                 695                 700                 


Glu Ile Ala Lys Gln Ile Gln Gly Gln Gly Ser Thr Pro Gln Thr Ala 
705                 710                 715                 720 


Leu Asp Leu Asp Asp Ala 
                725     


<210>  144
<211>  333
<212>  PRT
<213>  Artemisia annua


<220>
<221>  misc_feature
<222>  (219)..(219)
<223>  Xaa can be any naturally occurring amino acid

<400>  144

Met Ala Leu Lys His Leu Ile Phe Phe Thr Leu Leu Ser Ile Leu Ala 
1               5                   10                  15      


Ile Ser Ser Phe Ala Asp Thr Glu Ser Ser Thr Thr Thr Asp Ser Gly 
            20                  25                  30          


Leu Ala Leu Asn Phe Tyr Lys Asp Ser Cys Pro Gln Ala Glu Asp Ile 
        35                  40                  45              


Ile Arg Glu Gln Val Gly Leu Leu Tyr Lys Arg His Lys Asn Thr Ala 
    50                  55                  60                  


Phe Ser Trp Leu Arg Asn Ile Phe His Asp Cys Ala Val Glu Arg Cys 
65                  70                  75                  80  


Asp Ala Ser Leu Leu Leu Asp Ser Thr Arg Arg Gln Leu Ser Glu Lys 
                85                  90                  95      


Glu Thr Asp Arg Ser Phe Gly Leu Arg Asn Phe Arg Tyr Leu Glu Glu 
            100                 105                 110         


Ile Lys Glu Ala Val Glu Arg Glu Cys Pro Gly Val Val Ser Cys Ala 
        115                 120                 125             


Asp Ile Leu Val Leu Ser Gly Arg Asp Gly Ile Val Ala Val Gly Gly 
    130                 135                 140                 


Pro Tyr Ile Pro Leu Lys Thr Gly Arg Arg Asp Gly Arg Lys Ser Arg 
145                 150                 155                 160 


Ala Asp Ile Leu Glu Gln Tyr Leu Pro Asp His Asn Glu Ser Met Thr 
                165                 170                 175     


Val Val Leu Glu Arg Phe Lys Ser Ile Gly Ile Asp Thr Pro Gly Val 
            180                 185                 190         


Val Ala Leu Leu Gly Met Tyr Ile Ile Thr Ile Met His Thr Val His 
        195                 200                 205             


Val Arg His Ser Leu Asp Asn Pro Leu Ile Xaa Pro Ala Leu Asn Pro 
    210                 215                 220                 


Gly His Val Glu His Met Leu His Lys Cys Pro Asp Ala Ile Pro Asp 
225                 230                 235                 240 


Pro Lys Ala Val Gln Tyr Val Arg Asn Asp Arg Gly Thr Pro Met Lys 
                245                 250                 255     


Leu Asp Asn Asn Tyr Tyr Arg Asn Ile Leu Asp Asn Lys Gly Leu Leu 
            260                 265                 270         


Leu Val Asp His Gln Leu Ala Ile Asp Lys Arg Thr Lys Pro Tyr Val 
        275                 280                 285             


Lys Lys Met Ala Lys Asn Gln Asp Tyr Phe Phe Lys Gln Phe Ala Arg 
    290                 295                 300                 


Ala Ile Thr Ile Leu Thr Glu Asn Asn Pro Leu Thr Gly Asn Glu Gly 
305                 310                 315                 320 


Glu Ile Arg Gln Gln Cys Asn Val Ala Asn Lys His His 
                325                 330             


<210>  145
<211>  232
<212>  PRT
<213>  Artemisia annua

<400>  145

Met Glu Met Lys Ser Thr Ile Phe Ile Phe Ser Leu Ile Thr Leu Cys 
1               5                   10                  15      


Cys Leu Thr Phe Ser His Ala Ala Asp Pro Pro Leu Thr Leu Asp Tyr 
            20                  25                  30          


Tyr Lys Ser Thr Cys Pro Asn Ala Glu Ala Ile Val Arg Lys Glu Met 
        35                  40                  45              


Glu Cys Ala Val Thr Ser Asp Leu Arg Asn Ala Ala Ser Ile Leu Arg 
    50                  55                  60                  


Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Gly Ser Val Leu 
65                  70                  75                  80  


Leu Asp Asp Thr Tyr Met Leu Lys Gly Glu Lys Asn Ala Pro Thr Asn 
                85                  90                  95      


Leu Asn Ala Leu Lys Gly Phe Asp Ile Ile Asp Arg Ile Lys Asn Lys 
            100                 105                 110         


Leu Glu Ser Glu Cys Pro Gly Thr Val Ser Cys Ala Asp Val Leu Thr 
        115                 120                 125             


Tyr Ala Ala Arg Asp Ala Thr Val Leu Val Gly Gly Pro Tyr Trp His 
    130                 135                 140                 


Val Pro Ala Gly Arg Lys Asp Ser Lys Thr Ala Ser Ala Ser Leu Val 
145                 150                 155                 160 


Glu Ser Asn Ile Pro Gly Ala Asn Asp Gly Leu Leu Thr Met Ile Ser 
                165                 170                 175     


Lys Phe Met Tyr Gln Ser Leu Ser Val Thr Asp Met Val Ala Leu Ser 
            180                 185                 190         


Glu Asn Gln Leu Ala Phe Phe Glu Gln Phe Ser Glu Ser Met Val Lys 
        195                 200                 205             


Leu Gly Asn Ile Thr Asn Pro Glu Thr Tyr Val Asp Gly Glu Val Arg 
    210                 215                 220                 


Lys Asn Cys Arg Phe Val Asn Thr 
225                 230         


<210>  146
<211>  189
<212>  PRT
<213>  Artemisia annua

<400>  146

Met Gly Tyr Pro Lys Ser Ile Gly Thr Ile Leu Val Pro Ile Val Val 
1               5                   10                  15      


Leu Leu Val Ser Met Asn Tyr Met Pro Cys Lys Ala Gln Leu Thr Thr 
            20                  25                  30          


Thr Phe Tyr Asp Asp Thr Cys Pro Thr Ala Leu Thr Thr Ile Asn Asp 
        35                  40                  45              


Ser Ile Ser Ser Ala Val Ser Arg Asn Gly Arg Met Ala Ala Phe Ile 
    50                  55                  60                  


Ile Arg Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Glu Gly Gly Glu Lys Ala Ala Pro Ala Asn Asp Gly Val 
                85                  90                  95      


Glu Gly Tyr Glu Ala Ile Glu Ala Ala Lys Ala Ala Val Glu Ser Val 
            100                 105                 110         


Cys Gln Gly Val Val Ser Cys Ala Asp Ile Leu Ala Val Ala Ala Arg 
        115                 120                 125             


Asp Ala Ser Val Ala Val Gly Gly Pro Ser Trp Ala Val Arg Leu Gly 
    130                 135                 140                 


Arg Lys Asp Ser Leu Asp Ser Asn Pro Glu Gln Ala Ala Thr Asp Leu 
145                 150                 155                 160 


Pro Arg Gly Asp Asn Asn Leu Asp Gln Leu Ile Ala Ser Phe Ala Arg 
                165                 170                 175     


Lys Arg Leu Ser Val Arg Asp Met Val Ala Leu Ser Gly 
            180                 185                 


<210>  147
<211>  267
<212>  PRT
<213>  Artemisia annua

<400>  147

Met Ala Cys Phe Lys Asn Leu Phe Gly Ile Leu Met Leu Gln Met Val 
1               5                   10                  15      


Val Leu Ala Ile Ile Ser Ser His Ala Asp Gly Gln Gly Leu Lys Ile 
            20                  25                  30          


Gly Phe Tyr Glu Lys Ser Cys Pro Gln Ala Glu Lys Ile Val Phe Asn 
        35                  40                  45              


Val Met Lys Asp Val Met Ala Val Ala Pro Ser Leu Ser Gly Pro Leu 
    50                  55                  60                  


Leu Arg Met His Phe His Asp Cys Phe Ile Arg Thr Lys Gly Pro Phe 
65                  70                  75                  80  


Trp Glu Val Glu Thr Gly Arg Arg Asp Gly Lys Ile Ser Leu Ile Gly 
                85                  90                  95      


Asp Pro Ile Asn Pro Val Ser Gly Leu Pro Pro Phe Phe Leu Asn Ile 
            100                 105                 110         


Thr Ala Leu Lys Gln Ser Phe Ala Leu Arg Gly Leu Ser Val Lys Asp 
        115                 120                 125             


Leu Val Ala Leu Ser Gly Gly His Thr Gln Gly Met Ser His Cys Ser 
    130                 135                 140                 


Ser Phe Glu Asn Arg Leu Tyr Asn Phe Thr Gly Ile Gly Asp Thr Asp 
145                 150                 155                 160 


Pro Thr Met Asp Gln Asn Tyr Ile Ala Arg Leu Lys Leu Lys Ser Lys 
                165                 170                 175     


Pro Asn Asp Gln Thr Thr Ile Ala Glu Leu Asp Pro Gly Ser Phe Lys 
            180                 185                 190         


Thr Phe Asp Asp Ser Tyr Phe Arg Leu Val Asn Lys Arg Arg Gly Leu 
        195                 200                 205             


Leu Gln Ser Asp Ala Ala Leu Leu Asp Asp Pro Glu Thr Lys Ala Tyr 
    210                 215                 220                 


Met Ile Gln Ala Thr Ser Tyr Ser Ser Thr Phe Phe Lys Asp Phe Gly 
225                 230                 235                 240 


Val Ser Met Val Lys Met Gly Arg Ile Gly Val Leu Arg Gly Ser Gln 
                245                 250                 255     


Gly Glu Ile Arg Lys Val Cys Ser Lys Val Asn 
            260                 265         


<210>  148
<211>  259
<212>  PRT
<213>  Artemisia annua

<400>  148

Met Met Leu Val Met Ile Ile Leu Phe Lys Phe Leu Ile Val Phe Thr 
1               5                   10                  15      


Glu Ala Gln Leu Lys Val Gly Phe Tyr Asn Lys Val Cys Pro Ala Ala 
            20                  25                  30          


Glu Thr Val Val Ala Asn Val Val Lys Asp Ala Thr Lys Ser Asp Pro 
        35                  40                  45              


Gln Thr Pro Ala Phe Met Leu Arg Leu His Phe His Asp Cys Phe Val 
    50                  55                  60                  


Glu Ser His Gly Pro Val Tyr Gln Val Glu Thr Gly Arg Lys Asp Gly 
65                  70                  75                  80  


Leu Val Ser Arg Ile Glu Leu Ala Ala Arg Met Pro Asp Val Gln Asp 
                85                  90                  95      


Ser Ile Gln Ile Leu Lys Gln Lys Phe Ile Glu Lys Gly Leu Asn Asp 
            100                 105                 110         


Lys Asp Leu Val Ile Leu Ser Ala Ala His Thr Ile Gly Thr Ser Ala 
        115                 120                 125             


Cys Phe Phe Met Thr Thr Arg Leu Tyr Asp Phe Ala Ser Ser Gly Gly 
    130                 135                 140                 


Pro Asp Pro Ser Ile Asn Ala Ser Phe Leu Pro Glu Leu Thr Ser Ala 
145                 150                 155                 160 


Cys Pro Lys Gly Gly Asn Pro Asn Asp Arg Leu Pro Met Asp His Gly 
                165                 170                 175     


Ser Gly Asp Ile Phe Asp Lys Gln Ile Phe Gln Asn Ile Arg Ser Gly 
            180                 185                 190         


Phe Ala Val Leu Gln Ser Asp Ala Lys Leu Met Asp Asp Pro Thr Thr 
        195                 200                 205             


Lys Gly Ile Val Asp Ser Tyr Phe Gly Leu Leu Ser Pro Leu Thr Gly 
    210                 215                 220                 


Pro Ser Phe Glu Asp Asp Phe Met Ser Ser Met Val Arg Met Gly Arg 
225                 230                 235                 240 


Ile Gly Phe Lys Thr Gly Ser Thr Gly Asn Ile Arg Arg Val Cys Lys 
                245                 250                 255     


Ala Phe Asn 
            


<210>  149
<211>  181
<212>  PRT
<213>  Artemisia annua

<400>  149

Met Pro Ser Pro Arg Ala Asn Ala Ser Thr Leu Ile Asp Leu Phe Ala 
1               5                   10                  15      


Lys Phe Asp Leu Ser Ile Lys Asp Leu Val Ala Leu Ser Gly Ser His 
            20                  25                  30          


Ser Ile Gly Asn Gly Arg Cys Phe Ser Ile Val His Arg Leu Tyr Asn 
        35                  40                  45              


Gln Thr Asp Asp Gly Arg Pro Asp Pro Ser Ile Glu Pro Arg Tyr Arg 
    50                  55                  60                  


Gln Lys Leu Asp Lys Leu Cys Pro Leu Gly Gly Asp Glu Glu Val Ile 
65                  70                  75                  80  


Gly Asp Leu Asp Phe Thr Pro Arg Val Phe Asp Asn Gln Tyr Phe Lys 
                85                  90                  95      


Asp Leu Val Asn Gly Arg Gly Phe Leu Asn Ser Asp Glu Thr Leu Tyr 
            100                 105                 110         


Thr Phe Trp Gln Thr Arg Gly Tyr Val Gln Arg Tyr Ser Glu Asn Gln 
        115                 120                 125             


Ser Val Phe Phe Lys Asp Phe Val Glu Gly Met Ile Lys Met Gly Asp 
    130                 135                 140                 


Leu Gln Ser Gly Arg Pro Gly Glu Ile Arg Lys Asn Cys Arg Val Val 
145                 150                 155                 160 


Asn Asp Ala Pro Ser Val Glu Ile Val Met Arg Gly Ser Lys Asp Arg 
                165                 170                 175     


Lys Ile Leu Ser Phe 
            180     


<210>  150
<211>  210
<212>  PRT
<213>  Artemisia annua

<400>  150

Met Ala Ser Ser Lys Ile Ile Ser Phe Ala Leu Val Ala Ser Val Leu 
1               5                   10                  15      


Cys Leu Met Ser Ile Thr Ser Ser Gly Gly Pro Ala Trp Arg Ile Lys 
            20                  25                  30          


Leu Gly Arg Arg Asp Ser Arg Thr Ala Ser Leu Ser Ala Ala Asn Ile 
        35                  40                  45              


Gly Val Ile Pro Ser Pro Ser Ser Thr Leu Ser Asn Leu Ile Asn Arg 
    50                  55                  60                  


Phe His Ala Gln Gly Leu Ser Val Lys Asp Leu Val Ala Leu Ser Gly 
65                  70                  75                  80  


Ala His Thr Ile Gly Gln Ala Arg Cys Thr Thr Phe Arg Ala Arg Val 
                85                  90                  95      


His Asn Asp Ser Asn Ile Asp Thr Ser Phe Thr Arg Ser Arg Gln Ser 
            100                 105                 110         


Asn Cys Pro Leu Pro Thr Gly Leu Gly Asp Asn Asn Leu Ala Pro Leu 
        115                 120                 125             


Asp Val Lys Ser Pro Ala Tyr Phe Asp Asn Ser Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Ile Ser Glu Lys Gly Leu Leu Arg Ser Asp Gln Gln Leu Arg Ser Gly 
145                 150                 155                 160 


Gly Ala Thr Asp Phe Phe Val Glu Gln Tyr Ser Arg Asn Pro Glu Arg 
                165                 170                 175     


Phe Tyr Glu Asp Phe Thr Ala Ala Met Ile Lys Met Gly Asp Ile Ser 
            180                 185                 190         


Pro Leu Thr Gly Arg Asn Gly Glu Ile Arg Lys Asn Cys Arg Val Val 
        195                 200                 205             


Asn Ser 
    210 


<210>  151
<211>  300
<212>  PRT
<213>  Artemisia annua

<400>  151

Met Lys Leu Glu Pro Leu Ser Thr Thr Ile Asn Leu Ser Phe Ser Cys 
1               5                   10                  15      


Ser Ser Leu Ala Leu Asp Pro Arg Lys Met Phe Thr Tyr Glu Ile His 
            20                  25                  30          


Val Tyr Cys Val Ala Phe Ile Asn Thr Trp Leu Leu Val Thr Val Lys 
        35                  40                  45              


Ala Lys Val Ile Thr Glu Val Asp Ser Asn Ile Pro Leu Cys Glu Asn 
    50                  55                  60                  


Leu Thr Leu Leu Lys Leu Asn Cys Ile Gln Gly Cys Asp Ala Ser Val 
65                  70                  75                  80  


Leu Leu Asp Thr Thr Ala Asn Phe Thr Gly Glu Lys Gly Ala Gly Pro 
                85                  90                  95      


Asn Ala Gly Ser Ile Arg Gly Phe Asn Val Ile Asp Thr Ile Lys Thr 
            100                 105                 110         


Gln Leu Glu Ser Gln Cys Ala Gly Val Val Ser Cys Ala Asp Ile Leu 
        115                 120                 125             


Ala Ala Ala Ala Arg Asp Ser Val Val Ala Leu Gly Gly Pro Gly Trp 
    130                 135                 140                 


Asn Leu Val Phe Gly Arg Arg Asp Ser Thr Thr Ala Ser Ala Ser Thr 
145                 150                 155                 160 


Ala Asn Ser Asn Leu Pro Ala Pro Thr Leu Ser Leu Ser Gly Leu Ile 
                165                 170                 175     


Ser Ser Phe Ser Asn Gln Asn Leu Asn Ala Asn Glu Leu Val Ala Leu 
            180                 185                 190         


Ser Gly Ala His Thr Ile Asp Gln Ala Arg Cys Thr Thr Phe Arg Ser 
        195                 200                 205             


Arg Leu Thr Asp Asp Asn Asn Ile Asn Ala Ser Phe Ala Thr Ser Thr 
    210                 215                 220                 


Arg Ala Asn Cys Pro Thr Ser Gly Gly Asp Asn Asn Leu Ser Pro Leu 
225                 230                 235                 240 


Asp Ala Thr Pro Thr Ile Phe Asp Asn Ser Tyr Tyr Lys Asp Leu Ile 
                245                 250                 255     


Asn Gln Arg Gly Ile Lys Leu Trp Asp Gly Leu Gly Pro Glu Pro Arg 
            260                 265                 270         


Ala Gln Tyr Phe Arg Arg Ala Pro Ser Met Ile Val His Arg Tyr Met 
        275                 280                 285             


Val Leu Val His Glu Ala Phe Ser Gln Ala Gln Gln 
    290                 295                 300 


<210>  152
<211>  380
<212>  PRT
<213>  Artemisia annua

<400>  152

Met Arg Thr Ser Ser Lys Val Glu Val Phe Gly Arg Ala Ile Ser Thr 
1               5                   10                  15      


Glu Gly Phe Ser Ile Gln Asp Lys Val Val Asp Ile Val His Asp Asn 
            20                  25                  30          


Ala Trp Arg Trp Pro Ser Thr Trp Leu Val Arg Phe Pro Thr Leu Ser 
        35                  40                  45              


Ile Val Gln Val Pro Ile Leu His Asn Asn Gln Glu Asp Val Leu Tyr 
    50                  55                  60                  


Leu Lys Ser His Asp Gly Leu Phe Lys Asp Phe Ile Val Arg Asp Ile 
65                  70                  75                  80  


Trp His Ala Ile His Asp Arg Glu Thr Glu Val Ser Trp His Ser Phe 
                85                  90                  95      


Val Trp Ser Thr Tyr Gly Phe Pro Arg His Ser Ile His Val Trp Leu 
            100                 105                 110         


Leu Met Arg Lys Arg Leu Lys Thr Gln Asp Arg Leu Arg Gln Trp Asp 
        115                 120                 125             


Val Gly Ser Asp Val Asp Leu Asn Gln Leu Arg Cys Thr Leu Tyr Leu 
    130                 135                 140                 


Gly Ala Ile Ala Gly Cys Asp Ala Ser Val Leu Leu Asp Gln Thr Glu 
145                 150                 155                 160 


Val Met Gly Thr Glu Lys Thr Thr Leu Pro Asn Glu Ser Leu Lys Gly 
                165                 170                 175     


Phe Glu His Ile Asp Leu Ile Lys Ser Glu Leu Glu Asn Val Cys Pro 
            180                 185                 190         


Gly Val Val Ser Cys Ala Asp Leu Leu Val Met Ala Ala Arg Glu Ser 
        195                 200                 205             


Val Val Leu Val Gly Gly Pro Phe Tyr Pro Leu His Thr Gly Arg Lys 
    210                 215                 220                 


Asp Ser Val Gln Ser Tyr Pro Val Asp Ser Phe Gln Leu Pro Ser Pro 
225                 230                 235                 240 


Leu Asp Thr His His Gln Ser Ile Ala Arg Phe Thr Ala Arg Asn Phe 
                245                 250                 255     


Thr Glu Lys Glu Thr Val Thr Leu Leu Gly Ala His Ser Thr Gly Lys 
            260                 265                 270         


Ile His Cys Lys Phe Phe Glu Lys Arg Leu Tyr Asn Phe Asp Gly Thr 
        275                 280                 285             


Asn Gln Pro Asp Pro Ser Met Asp Pro Glu Phe Val Glu Leu Leu Arg 
    290                 295                 300                 


Thr Ile Leu Leu Gln Gly Arg Gly Ile Leu Phe Val Asp Gln Gln Met 
305                 310                 315                 320 


Thr Ala Gly Glu Asn Thr Ser Asn Trp Val Arg Gln Tyr Ala Ser Asp 
                325                 330                 335     


Val Ser Met Phe His Lys Asp Phe Ala Gln Val Met Met Lys Leu Ser 
            340                 345                 350         


Asn Tyr Gln Val Leu Thr Gly Ser Gln Gly Asp Val Arg Gln Asn Cys 
        355                 360                 365             


Arg Glu Val Thr Thr Ser Leu Trp Gln Val Val Pro 
    370                 375                 380 


<210>  153
<211>  195
<212>  PRT
<213>  Artemisia annua

<400>  153

Met Lys Val Gly Asn Ile Cys Thr Tyr Phe Ala Pro Gln Val Asp Val 
1               5                   10                  15      


Asp Cys Asn Glu Val Cys Thr Leu Tyr Met Trp Thr Pro Ser Lys Val 
            20                  25                  30          


Ser Thr Ala Gln Met His Ala Met Gly His His Glu Asp Ser Trp Ala 
        35                  40                  45              


Gly Gly Pro Ser Tyr Ser Val Glu Leu Gly Arg Phe Asp Trp Leu Ser 
    50                  55                  60                  


Ser Thr Ala Ala Ser Val Gly Gly Lys Met Leu Lys Pro Asn Gln Asn 
65                  70                  75                  80  


Leu Asp Gln Leu Asn Ala Leu Phe Thr Ala Asp Gly Leu Thr Gln Ala 
                85                  90                  95      


Asp Met Ile Ala Leu Ser Gly Phe Tyr Phe Val Ser Phe Val Ala Leu 
            100                 105                 110         


Val Lys Thr Gly His Asp Val Ala Leu Ile Asn Arg Phe His Val Phe 
        115                 120                 125             


Asn Ile Tyr Lys Ile Glu Asn Glu Leu Asp Leu Asn Gln His Val Pro 
    130                 135                 140                 


Tyr Leu Val Val Lys Asp Ala Ser Ser Glu Gly Met Gln His Pro Ala 
145                 150                 155                 160 


Val Ala Ser His Thr Lys Lys Asn Val Tyr Leu Arg Glu Asp Gly Phe 
                165                 170                 175     


Pro Val Ile Glu Gly Ser Asn Ile Asn Thr Ser Val Ile Ile Ser Arg 
            180                 185                 190         


Cys Arg Ser 
        195 


<210>  154
<211>  153
<212>  PRT
<213>  Artemisia annua

<400>  154

Met Asp Leu Pro Ala Leu Ile Lys Ser Phe Glu Asp Gln Gly Leu Asp 
1               5                   10                  15      


Glu Glu Asp Leu Val Val Leu Ser Gly Ala His Thr Leu Gly Phe Ala 
            20                  25                  30          


Gln Cys Arg Thr Phe Arg Pro His Ile Tyr Asn Asp Asn Asn Ile Asp 
        35                  40                  45              


Pro Ala Phe Ala Ser Gln Leu Arg Asn Asn Cys Pro Gln Val Gly Gly 
    50                  55                  60                  


Asp Ser Asn Ile Ala Pro Leu Asp Pro Thr Pro Ser Ser Phe Asp Thr 
65                  70                  75                  80  


Arg Tyr Phe Asn Asn Leu Met Ser Lys Arg Gly Val Leu Arg Ser Asp 
                85                  90                  95      


Gln Ala Leu Phe Asn Gly Gly Glu Thr Asp Glu Leu Val Ser Lys Tyr 
            100                 105                 110         


Asn Glu Asn Tyr Glu Lys Phe Leu Lys Asp Phe Ala Lys Ser Met Ile 
        115                 120                 125             


Lys Met Gly Asn Ile Asn Leu Leu Thr Gly Asn Arg Gly Gln Ile Arg 
    130                 135                 140                 


Asp Asn Cys Arg Arg Ile Asn Ser Gln 
145                 150             


<210>  155
<211>  320
<212>  PRT
<213>  Artemisia annua

<400>  155

Met Arg Gly Phe Trp Ser Phe Gly Ile Thr Val Leu Gly Phe Ile Ser 
1               5                   10                  15      


Ile Leu Gly Ser Val Gln Gly Asp Leu Gln Thr Gly Phe Tyr Ser Ser 
            20                  25                  30          


Ser Cys Pro Lys Ala Glu Lys Ile Ile Lys Asp Tyr Val Asn Gln His 
        35                  40                  45              


Ile Pro Asn Ala Pro Ser Leu Ala Ala Thr Leu Ile Arg Met His Phe 
    50                  55                  60                  


His Asp Cys Phe Val Arg Gly Cys Asp Ala Ser Ile Leu Leu Asn Phe 
65                  70                  75                  80  


Thr Ser Ala Ser Gly Asn Gln Thr Glu Lys Val Ala Thr Pro Asn Gln 
                85                  90                  95      


Thr Val Arg Gly Phe Asp Phe Ile Asp Arg Ile Lys Ser Leu Leu Glu 
            100                 105                 110         


Ala Glu Cys Pro Ser Ile Val Ser Ser Ala Asp Ile Ile Ser Leu Ala 
        115                 120                 125             


Ala Arg Asp Ser Ile Val Val Thr Gly Gly Pro Phe Trp Lys Val Pro 
    130                 135                 140                 


Thr Gly Arg Arg Asp Gly Leu Phe Ser Asn Ala Ser Glu Ala Leu Ala 
145                 150                 155                 160 


Gln Ile Pro Ala Pro Phe Asp Asn Ile Thr Ile Leu Thr Gln Lys Phe 
                165                 170                 175     


Ala Asn Lys Ser Leu Asn Leu Lys Asp Leu Val Leu Leu Ser Gly Gly 
            180                 185                 190         


Phe Phe Val Lys Ser Val Arg Asn Leu Val Asp Gly Ser Leu Ile Ser 
        195                 200                 205             


Ser Asp Met Leu Leu Thr Arg Trp Val Lys Val Val Pro Ile Lys Ile 
    210                 215                 220                 


Asn Leu Phe Ala Trp Lys Val Gln Asn Asp Lys Leu Leu Thr Arg Leu 
225                 230                 235                 240 


Asn Leu Ser Trp Leu Gly Ile Asp Ile His Ser Ile Met Tyr Pro Ile 
                245                 250                 255     


Cys Glu Glu Glu Ala Glu Ser Leu Ala His Leu Leu Phe Ser Cys Ser 
            260                 265                 270         


Ile Ala Arg Lys Val Leu Ser Lys Ala Arg Arg Trp Leu Gly Val Ser 
        275                 280                 285             


Ser Gln Asp Phe Gln Ser Tyr Glu Glu Trp Leu Leu Trp Phe Ser Asp 
    290                 295                 300                 


Leu Arg Met Arg Met Gln Val Lys Asn Met Gln Glu Gly Val Phe Met 
305                 310                 315                 320 


<210>  156
<211>  168
<212>  PRT
<213>  Artemisia annua

<400>  156

Met Asp Ser Arg Lys Ser Ile Leu Phe Val Val Phe Leu Ala Thr Leu 
1               5                   10                  15      


Ile Thr Leu Ala Leu Gly Gln Thr Arg Val Gly Phe Tyr Arg Thr Ser 
            20                  25                  30          


Cys Pro Arg Val Glu Thr Ile Val Gln Thr Ala Val Arg Ser Ala Val 
        35                  40                  45              


Asn Ser Asn Pro Thr Ile Ala Pro Gly Leu Leu Arg Met Phe Phe His 
    50                  55                  60                  


Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile Leu Ile Asp Gly Ala 
65                  70                  75                  80  


Ser Ser Glu Lys Thr Ala Leu Pro Asn Ser Leu Leu Arg Gly Phe Glu 
                85                  90                  95      


Val Ile Asp Ala Ala Lys Thr Gln Leu Glu Thr Ala Cys Pro Gly Val 
            100                 105                 110         


Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val 
        115                 120                 125             


Gln Asp Arg Val Ile Ser Val Asn Val Pro Ser Val Val Val Lys Glu 
    130                 135                 140                 


Leu Lys Glu Arg Phe Leu Pro Cys Gly Cys Ile Ser His Gln Thr His 
145                 150                 155                 160 


Phe Gly Ile Met Gly Gln Ser Thr 
                165             


<210>  157
<211>  123
<212>  PRT
<213>  Artemisia annua

<400>  157

Met Ala Ser Gly Gln Leu Thr Ala Asn Phe Tyr Ala Ser Ser Cys Pro 
1               5                   10                  15      


Asn Phe Ser Ala Thr Ile Ser Thr Ala Val Asn Ser Ala Val Ser Asn 
            20                  25                  30          


Glu Ala Arg Met Gly Ala Ser Leu Leu Arg Leu His Phe His Asp Cys 
        35                  40                  45              


Phe Val Asn Gly Cys Asp Ala Ser Val Leu Leu Asp Asp Thr Ala Asn 
    50                  55                  60                  


Phe Thr Gly Glu Lys Thr Ala Ala Pro Asn Asn Asn Ser Leu Arg Gly 
65                  70                  75                  80  


Phe Asp Val Ile Asp Thr Ile Lys Ser Gln Leu Glu Ser Ser Cys Pro 
                85                  90                  95      


Gly Val Val Ser Cys Ala Asp Ile Leu Ala Thr Ala Ala Arg Asp Ser 
            100                 105                 110         


Val Val Ala Val Arg Asn Ile Asn Gln Phe Cys 
        115                 120             


<210>  158
<211>  228
<212>  PRT
<213>  Artemisia annua


<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa can be any naturally occurring amino acid

<400>  158

Met Ala Ile Asn Thr Ser His Glu Pro Gln Ala Pro Thr His Lys Leu 
1               5                   10                  15      


Ile Phe Met Ala Met Ala Phe Ser Lys Ala Ser Cys Gln Ser Thr Leu 
            20                  25                  30          


Ile Phe Ala Leu Phe Leu Leu Cys Asn Leu Arg Ala Leu Glu Ala Gln 
        35                  40                  45              


Thr Pro Ala Pro Ala Pro Gly Leu Ser Tyr Thr Phe Tyr Arg Thr Thr 
    50                  55                  60                  


Cys Pro Asn Leu Glu Thr Ile Ile Arg Gln Gln Leu Gln Thr Val Phe 
65                  70                  75                  80  


Ala Ser Asp Ile Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His 
                85                  90                  95      


Asp Cys Phe Val Gln Gly His Asp Ala His Asp Asn Gln Gln Xaa Arg 
            100                 105                 110         


Leu Thr Cys Pro Thr Asn Thr Ser Asn Asn Thr Thr Val Leu Asp Ile 
        115                 120                 125             


Arg Ser Pro Asn Val Phe Asp Asn Lys Tyr Tyr Val Asp Leu Met Asn 
    130                 135                 140                 


Arg Gln Gly Leu Phe Thr Ser Asp Gln Asp Leu Tyr Thr Asp Ser Arg 
145                 150                 155                 160 


Thr Arg Thr Ile Val Thr Asn Phe Ala Val Asn Gln Thr Leu Phe Tyr 
                165                 170                 175     


Gln Asn Phe Ile Asn Ala Met Ile Lys Met Gly Gln Leu Asn Val Leu 
            180                 185                 190         


Thr Gly Thr Gln Gly Glu Ile Arg Ala Asn Cys Ser Arg Arg Asn Ser 
        195                 200                 205             


Asn Asp Leu Phe Ile Leu Pro Thr Met Glu Asn Asp Gln Asp Glu Lys 
    210                 215                 220                 


Val Ala Ser Tyr 
225             


<210>  159
<211>  138
<212>  PRT
<213>  Artemisia annua

<400>  159

Met Gly Tyr Pro Lys Ser Ile Gly Thr Ile Leu Val Pro Ile Val Val 
1               5                   10                  15      


Leu Leu Val Ser Met Asn Tyr Met Pro Cys Lys Ala Gln Leu Ser Ala 
            20                  25                  30          


Thr Phe Tyr Asp Asp Thr Cys Pro Thr Ala Leu Thr Thr Ile Asn Asp 
        35                  40                  45              


Ser Ile Ser Ser Ala Val Ser Arg Asn Arg Arg Met Ala Ala Phe Ile 
    50                  55                  60                  


Ile Arg Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Glu Gly Gly Glu Lys Ala Ala Pro Ala Asn Asp Gly Val 
                85                  90                  95      


Glu Gly Tyr Pro Ala Ile Asp Ala Ala Lys Ala Ala Val Glu Ser Val 
            100                 105                 110         


Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Val Ala Ala Arg 
        115                 120                 125             


Asp Ala Ser Val Gly Val Met Thr Lys Pro 
    130                 135             


<210>  160
<211>  126
<212>  PRT
<213>  Artemisia annua

<400>  160

Met Asp Leu Pro Ala Leu Ile Lys Asn Phe Glu Asp Gln Gly Leu Asp 
1               5                   10                  15      


Glu Glu Asp Leu Val Val Leu Ser Gly Val His Thr Leu Gly Phe Ala 
            20                  25                  30          


Gln Cys Phe Thr Phe Arg Asp His Ile Tyr Asn Asn Thr Asn Ile Asp 
        35                  40                  45              


Pro Ala Phe Ala Gly His Leu Lys Ile Ile Cys Pro Arg Val Gly Gly 
    50                  55                  60                  


Asp Ser Asn Leu Thr Pro Leu Asp Pro Thr Pro Ser Pro Phe Asp Thr 
65                  70                  75                  80  


Lys Tyr Phe Asn Asn Leu Met Arg Lys Arg Gly Val Leu Lys Ser Asp 
                85                  90                  95      


Gln Val Leu Phe Ser Lys Gly Glu Thr Ser Glu Leu Val Ser Glu Tyr 
            100                 105                 110         


Asn Glu Gly Gln Thr Lys Phe Phe Lys Asp Leu Gln Ser Leu 
        115                 120                 125     


<210>  161
<211>  706
<212>  PRT
<213>  Artemisia annua

<400>  161

Met Asp Leu Pro Ala Leu Ile Lys Asn Phe Glu Asp Gln Gly Leu Asp 
1               5                   10                  15      


Glu Glu Asp Leu Val Val Leu Ser Gly Val His Thr Leu Gly Phe Ala 
            20                  25                  30          


Gln Cys Phe Thr Phe Arg Asp His Ile Tyr Asn Asn Thr Asn Ile Asp 
        35                  40                  45              


Pro Ala Phe Ala Gly His Leu Lys Ile Ile Cys Pro Arg Val Gly Gly 
    50                  55                  60                  


Asp Ser Asn Leu Thr Pro Leu Asp Pro Thr Pro Ser Pro Phe Asp Thr 
65                  70                  75                  80  


Lys Tyr Phe Asn Asn Leu Met Arg Lys Arg Gly Val Leu Lys Ser Asp 
                85                  90                  95      


Gln Val Leu Phe Ser Lys Gly Glu Thr Ser Glu Leu Val Ser Glu Tyr 
            100                 105                 110         


Asn Glu Gly Arg Phe Asp Ser Leu Asn Ser Leu Thr His Leu Arg Ile 
        115                 120                 125             


Leu Ser Leu Lys Asn Asn Arg Leu Thr Gly Pro Val Pro Asp Leu Ser 
    130                 135                 140                 


Asn Leu Thr Ser Leu Lys Leu Leu Phe Leu Ser Asn Asn Phe Ile Ser 
145                 150                 155                 160 


Gly Ala Phe Pro Pro Ser Leu Pro Ser Leu Phe Gly Leu Tyr Arg Leu 
                165                 170                 175     


Asp Leu Ser Phe Asn Asn Phe Ser Gly Glu Ile Pro Ala Thr Leu Asn 
            180                 185                 190         


Thr Met Ile Asp Ile Val Phe Pro Leu Asp Trp Arg Lys Ser Val Asp 
        195                 200                 205             


Glu Asp Leu Ile Ser Leu Lys Glu Thr Asp Leu Ser Val Asn Leu Leu 
    210                 215                 220                 


Glu Asp Ile Ile Leu Gln Ala Val Asp Ile Lys Ala Leu Glu Arg Val 
225                 230                 235                 240 


Ile Ile Ile Cys Leu Cys Ser Arg Val Ser Val Ala Val Tyr Glu Asn 
                245                 250                 255     


Leu Ile Asn Lys Leu Lys Asp Lys Pro Gln Phe Lys Ser Phe Val Glu 
            260                 265                 270         


Lys Phe Arg Gly Gly Gly Leu Lys Asp Val Leu Val Ala Pro Thr Leu 
        275                 280                 285             


Gln Arg Ala Leu Glu Asp Asn Phe Arg Val Ala Ser Gly Phe Leu Ser 
    290                 295                 300                 


Pro His Ser Phe Gly Val Leu Val Glu Arg Ile Gln Asp Ile Leu Cys 
305                 310                 315                 320 


Phe Ser Glu Asn Thr Met Ala Pro Asn Tyr Ser Pro Lys Leu Leu Tyr 
                325                 330                 335     


Phe Leu Ser Gly Tyr Asp Asn Ile Ala Tyr Phe Leu Pro Lys Lys Phe 
            340                 345                 350         


Leu Cys Ser Leu Leu Arg Lys Arg Val Asn Gln Lys Leu Asn Leu Asp 
        355                 360                 365             


Pro Glu Val Val Ala Glu Ala Phe Leu Ser Ile Asp Asp Pro Leu Leu 
    370                 375                 380                 


Ile Val Arg Ser Glu Asn Val Gly Pro Lys Val Asn Ala Pro Cys Ala 
385                 390                 395                 400 


Ile Phe Leu Asp Leu Glu Lys Ser Lys Glu Glu Ile Met Ser Ile Leu 
                405                 410                 415     


Phe Pro Ser Lys Asn Thr His Asn Val His Thr Pro Ser Asn Asn Val 
            420                 425                 430         


Asn Ala Gly Thr Ile Pro Glu Ile Leu Ser Ser Asp Thr Leu Gln Asp 
        435                 440                 445             


Thr Asn Ile Met Asn Arg Val Glu Leu Gln Ile Asn Trp Lys Val Leu 
    450                 455                 460                 


Glu Glu Ile Tyr Glu Ala Ile Asn Gly Lys Lys Gly Val Ala Leu Asn 
465                 470                 475                 480 


Lys Leu Ser Ala Ala Thr Met Ile Lys Asn Glu Leu Asp Ile Asn Arg 
                485                 490                 495     


Gly Thr Leu Leu Thr Thr Phe Ala Ala Gln Thr Ser Cys Ser Asn Lys 
            500                 505                 510         


Asp Ala Arg Ala Ile Arg Asp Ala Asn Glu Asp Leu Lys Leu Leu Ser 
        515                 520                 525             


Phe Ala Phe Tyr Thr Ser Gln Leu Glu Leu Lys His Ser Val Ile Leu 
    530                 535                 540                 


Lys Gly Val Ser Arg Ala Val Lys Gly Leu Gln Ser His Arg Pro Lys 
545                 550                 555                 560 


Leu Asp Asn Phe Leu Asn Arg Ser Ser Met Asn Gln Ala Ile Lys Leu 
                565                 570                 575     


Ser Leu Arg Gly Asn His Asp His Phe Asn Val Gln Gln Asp Asp Tyr 
            580                 585                 590         


Gly Leu Ser Thr Lys Tyr Tyr Asp Arg Val Cys Pro Gln Ala Leu Pro 
        595                 600                 605             


Thr Ile Lys Arg Val Val Glu Asp Ala Val Ala Gln Glu Arg Arg Met 
    610                 615                 620                 


Gly Ala Ser Leu Leu Arg Leu His Phe His Asp Cys Phe Val Asn Gly 
625                 630                 635                 640 


Cys Asp Ala Ser Ile Leu Leu Asp Gln Thr Ser Thr Ile Asp Thr Glu 
                645                 650                 655     


Lys Asn Ala Val Ala Asn Val Asp Ser Ala Arg Gly Phe Asp Val Ile 
            660                 665                 670         


Asp Lys Ile Lys Ser Glu Val Asp Lys Ile Cys Gly Arg Pro Ile Val 
        675                 680                 685             


Ser Cys Ala Asp Ile Leu Thr Val Ala Ala Arg Asp Ser Val Val Ala 
    690                 695                 700                 


Val Ser 
705     


<210>  162
<211>  536
<212>  PRT
<213>  Artemisia annua

<400>  162

Met Pro Lys Arg Tyr Arg Phe Pro Val His Gly Thr Val Pro Arg Val 
1               5                   10                  15      


Arg Asn Lys Val Ile Lys Arg Val Pro Phe Lys Met Val Trp Glu Leu 
            20                  25                  30          


Phe Glu Lys Ser Arg Phe Gly Thr Arg Ile Gln Lys Arg Gly Leu Lys 
        35                  40                  45              


Ala Val Asn Val Ser Gly Gly Lys Leu Gly Thr Ala Val Thr Thr Lys 
    50                  55                  60                  


Cys Phe Ala Ser Asp Pro Ala Gln Leu Lys Ser Ala Arg Glu Asp Ile 
65                  70                  75                  80  


Lys Glu Leu Leu Lys Thr Thr Phe Cys His Pro Ile Leu Met Gly Ser 
                85                  90                  95      


Phe Leu Asn Glu Met Leu Ala Asn Asn Trp Thr Cys Val Arg Arg Val 
            100                 105                 110         


Ala Val Arg Leu Gly Trp His Asp Ala Gly Thr Tyr Asn Lys Asn Ile 
        115                 120                 125             


Glu Glu Trp Pro Gln Arg Gly Gly Ala Asn Gly Ser Leu Val Asn Ala 
    130                 135                 140                 


Leu Lys Leu Leu Gln Pro Ile Lys Asp Lys Tyr Thr Gly Val Thr Tyr 
145                 150                 155                 160 


Ala Asp Leu Phe Gln Leu Ala Ser Ala Thr Ala Val Glu Glu Ala Gly 
                165                 170                 175     


Gly Pro Lys Leu Pro Met Lys Tyr Gly Arg Val Asp Val Ser Gly Pro 
            180                 185                 190         


Glu Gln Cys Pro Glu Glu Gly Arg Leu Pro Asp Phe Thr Ala Val Phe 
        195                 200                 205             


Leu His Phe Pro Leu Val Ser Val Met His Val Phe Ser Cys Ala Phe 
    210                 215                 220                 


Ile Ile Ala Tyr Glu Leu Arg Ser Gln His Val Arg Leu Gly Trp His 
225                 230                 235                 240 


Asp Ala Gly Thr Tyr Asn Lys Asn Ile Glu Glu Trp Pro Gln Arg Gly 
                245                 250                 255     


Gly Ala Asn Gly Ser Leu Val Asn Ala Leu Lys Leu Leu Gln Pro Ile 
            260                 265                 270         


Lys Asp Lys Tyr Thr Gly Val Thr Tyr Ala Asp Leu Phe Gln Leu Ala 
        275                 280                 285             


Ser Ala Thr Ala Val Glu Glu Ala Gly Gly Pro Lys Leu Pro Met Lys 
    290                 295                 300                 


Tyr Gly Arg Val Asp Val Ser Gly Pro Glu Gln Cys Pro Glu Glu Gly 
305                 310                 315                 320 


Arg Leu Pro Asp Ala Gly Pro Pro Ser Pro Ala Asp His Leu Arg Asp 
                325                 330                 335     


Val Phe Tyr Arg Met Gly Leu Ser Asp Lys Asp Ile Val Ala Leu Ser 
            340                 345                 350         


Gly Ala His Thr Leu Gly Arg Ser Arg Pro Glu Arg Ser Gly Trp Gly 
        355                 360                 365             


Lys Pro Glu Thr Lys Tyr Thr Lys Glu Gly Pro Gly Ala Pro Gly Gly 
    370                 375                 380                 


Gln Ser Trp Thr Val Lys Trp Leu Arg Phe Asp Asn Ser Tyr Phe Lys 
385                 390                 395                 400 


Asp Ile Lys Glu Lys Arg Asp Glu Asp Leu Leu Val Leu Pro Thr Asp 
                405                 410                 415     


Ala Ala Leu Phe Asp Asp Pro Ser Phe Lys Val Phe Ala Glu Lys Tyr 
            420                 425                 430         


Ala Glu Asp Glu Lys Ala Phe Phe Thr Asp Tyr Ala Glu Ala His Ala 
        435                 440                 445             


Lys Leu Ser Asn Leu Gly Ala Lys Phe Asp Pro Ala Glu Gly Phe Ser 
    450                 455                 460                 


Ile Asp Asp Glu Pro Ala Ala Pro Val Gly Glu Lys Phe Val Ala Ala 
465                 470                 475                 480 


Lys Tyr Ser Ser Gly Lys Arg Glu Leu Ser Asp Ala Met Lys Gln Lys 
                485                 490                 495     


Ile Arg Ser Glu Tyr Val Gly Phe Gly Gly Ser Pro Asp Lys Pro Leu 
            500                 505                 510         


Gln Ser Asn Tyr Phe Leu Asn Ile Ile Ile Val Ile Ala Val Leu Ala 
        515                 520                 525             


Ile Leu Thr Ser Leu Val Gly Asn 
    530                 535     


<210>  163
<211>  291
<212>  PRT
<213>  Artemisia annua

<400>  163

Met Ala Gly Lys Gly Leu Val Val Asp Ala Glu Tyr Leu Lys Glu Ile 
1               5                   10                  15      


Glu Lys Ala Arg Arg Asp Leu Arg Ala Leu Ile Ser Asn Lys Asn Cys 
            20                  25                  30          


Ala Pro Ile Met Leu Arg Leu Ala Trp His Asp Ala Gly Thr Tyr Asp 
        35                  40                  45              


Ala Lys Thr Lys Thr Gly Gly Pro Asn Gly Ser Ile Arg Asn Glu Gln 
    50                  55                  60                  


Glu Tyr Arg His Ala Ala Asn Asn Gly Leu Lys Ile Ala Ile Asp Leu 
65                  70                  75                  80  


Cys Glu Glu Val Lys Ala Lys His Pro Arg Ile Thr Tyr Ala Asp Leu 
                85                  90                  95      


Tyr Gln Leu Ala Gly Val Val Ala Val Glu Val Thr Gly Gly Pro Thr 
            100                 105                 110         


Ile Asp Phe Val Pro Gly Arg Lys Asp Ser Asn Glu Ser Pro Asn Glu 
        115                 120                 125             


Gly Arg Leu Pro Asp Ala Lys Gln Gly Ser Ser His Leu Arg Asp Val 
    130                 135                 140                 


Phe Tyr Arg Met Gly Leu Ser Asp Lys Asp Ile Val Ala Leu Ser Gly 
145                 150                 155                 160 


Gly His Thr Leu Gly Lys Ala His Pro Glu Arg Ser Gly Phe Glu Glu 
                165                 170                 175     


Lys Pro Trp Thr Lys Asp Pro Leu Lys Phe Asp Asn Ser Tyr Phe Val 
            180                 185                 190         


Glu Leu Leu Lys Gly Asp Asp Ala Gly Leu Leu Lys Leu Pro Thr Asp 
        195                 200                 205             


Lys Ala Leu Val Glu Asp Pro Lys Phe Arg Tyr Tyr Val Glu Leu Tyr 
    210                 215                 220                 


Ala Lys Asp Glu Glu Ala Phe Phe Lys Asp Tyr Ala Glu Ser His Lys 
225                 230                 235                 240 


Lys Leu Ser Glu Leu Gly Phe Lys Pro Pro Leu Ser Cys Leu Lys Leu 
                245                 250                 255     


Ser Ser Lys Asn Ala Ala Leu Leu Ala Gln Ser Ala Val Gly Val Ala 
            260                 265                 270         


Val Ala Ala Thr Val Val Ile Leu Ser Tyr Phe Tyr Glu Val Asn Arg 
        275                 280                 285             


Lys Phe Lys 
    290     


<210>  164
<211>  285
<212>  PRT
<213>  Artemisia annua

<400>  164

Met Ala Met Pro Ile Val Asp Thr Glu Tyr Leu Lys Gln Ile Glu Lys 
1               5                   10                  15      


Ala Arg Arg Glu Leu Arg Ala Phe Ile Ala Asn Lys Asn Cys Ala Pro 
            20                  25                  30          


Ile Met Leu Arg Leu Ala Trp His Asp Ala Gly Thr Tyr Asp Val Asn 
        35                  40                  45              


Thr Lys Thr Gly Gly Pro Asn Gly Ser Ile Arg Ser Glu Glu Glu Tyr 
    50                  55                  60                  


Thr His Gly Ser Asn Asn Gly Leu Lys Ile Ala Ile Asp Phe Cys Glu 
65                  70                  75                  80  


Glu Ile Lys Ser Lys His Pro Arg Ile Thr Tyr Ala Asp Leu Tyr Gln 
                85                  90                  95      


Leu Ala Gly Val Val Ala Val Glu Val Thr Gly Gly Pro Thr Val Asp 
            100                 105                 110         


Phe Val Pro Gly Arg Lys Asp Ser Thr Ile Ser Pro Lys Glu Gly Arg 
        115                 120                 125             


Leu Pro Asn Ala Thr Lys Gly Ala Pro His Leu Arg Asp Ile Phe Tyr 
    130                 135                 140                 


Arg Met Gly Leu Ser Asp Lys Asp Ile Val Ala Leu Ser Gly Gly His 
145                 150                 155                 160 


Thr Leu Gly Arg Ala His Ala Asp Arg Ser Gly Phe Glu Gly Pro Trp 
                165                 170                 175     


Thr Arg Glu Pro Leu Lys Phe Asp Asn Ser Tyr Phe Val Glu Leu Leu 
            180                 185                 190         


Lys Gly Glu Ser Glu Gly Leu Leu Lys Leu Pro Thr Asp Ile Ala Leu 
        195                 200                 205             


Leu Asp Asp Pro Ala Phe Arg His Tyr Val Asp Leu Tyr Ala Lys Asp 
    210                 215                 220                 


Glu Asp Ala Phe Phe Asn Asp Tyr Ala Leu Ser His Lys Lys Leu Ser 
225                 230                 235                 240 


Glu Leu Gly Phe Thr Pro Gly Ser Ser Lys Lys Val Lys Asp Ser Val 
                245                 250                 255     


Val Leu Ala Gln Ser Ala Val Gly Val Ile Val Thr Ala Ala Val Val 
            260                 265                 270         


Ile Leu Ser Tyr Val Tyr Glu Ala Arg Lys Arg Ser Lys 
        275                 280                 285 


<210>  165
<211>  165
<212>  PRT
<213>  Artemisia annua

<400>  165

Met Gln Lys Met Asn Ile Ile Ser Phe Leu Ser Leu Phe Val Phe Phe 
1               5                   10                  15      


Met Phe Gln Ile Ala Thr Ala Ser Ser Asp Asp Tyr Gly Leu Ser Thr 
            20                  25                  30          


Glu Tyr Tyr Asn Arg Val Cys Pro Gln Ala Leu Pro Thr Ile Lys Arg 
        35                  40                  45              


Val Val Glu Asp Ala Val Ala Gln Glu Arg Arg Met Gly Ala Ser Leu 
    50                  55                  60                  


Leu Arg Leu His Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser 
65                  70                  75                  80  


Ile Leu Leu Asp Gln Thr Ser Thr Ile Asp Ser Glu Lys Asn Ala Gly 
                85                  90                  95      


Ala Asn Val Asn Ser Ala Arg Gly Phe Glu Leu Gly Val Leu Gly Glu 
            100                 105                 110         


Ser Leu Ile Arg Gly Gly Val Glu Ala Ile Thr Ala Val Ile Arg Arg 
        115                 120                 125             


Gln Trp Ala Glu Glu Asn Pro Val Ile Thr Phe Ser Phe Thr Leu Val 
    130                 135                 140                 


Pro Ala Ala Tyr Lys Ser Arg Ser Gly Asp Gly Met Arg Arg Arg Leu 
145                 150                 155                 160 


Val Asp Asn Glu Ala 
                165 


<210>  166
<211>  197
<212>  PRT
<213>  Artemisia annua

<400>  166

Met Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Gly Ser Ile Leu 
1               5                   10                  15      


Ile Asp Gly Pro Ser Ala Glu Lys Thr Val Val Pro Asn Val Pro Ile 
            20                  25                  30          


Arg Gly Phe Glu Val Ile Asp Ala Ala Lys Thr Gln Leu Glu Ala Thr 
        35                  40                  45              


Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala Arg 
    50                  55                  60                  


Asp Ser Val Val Leu Leu Cys Ile Ser Cys Arg Val Val Asp Val Asp 
65                  70                  75                  80  


Gly Lys Cys Gln Arg Asp Gly Glu Met Asp Trp Phe His Lys His Leu 
                85                  90                  95      


Ile Leu Gln Ile Tyr Gln Pro Leu Thr Ile Gln Leu Ala Ser Lys Ser 
            100                 105                 110         


Glu Ser Phe Leu Lys Lys Val Leu Thr Leu Lys Ile Leu Leu Leu Leu 
        115                 120                 125             


Leu Glu Leu Thr Asn Leu Leu Gly Gln Gln Thr Lys Arg Leu Ala Gly 
    130                 135                 140                 


Phe Glu Gly Val Gln Glu Val Arg Asp Ile Ser Gly Ser Pro His Ser 
145                 150                 155                 160 


His Leu Ile Asp Asp Ile Ala Ile Gly Leu Glu Ile Arg Val Tyr Gln 
                165                 170                 175     


Ile Glu Leu Arg Val Leu Ile Trp Gly Gln Thr Gly Ile Ala Met Val 
            180                 185                 190         


Glu Leu Ser Gly Val 
        195         


<210>  167
<211>  88
<212>  PRT
<213>  Artemisia annua

<400>  167

Met Gly Ser His Asp Phe Tyr Ser Arg Thr Cys Pro Asn Val Phe Glu 
1               5                   10                  15      


Ala Val Gly Ser Val Val Arg Ser Ala Val Ser Arg Glu Lys Arg Met 
            20                  25                  30          


Gly Ala Ser Leu Leu Arg Leu His Phe His Asp Tyr Phe Val Asn Gly 
        35                  40                  45              


Cys Asp Gly Ser Val Leu Leu Asp Asp Thr Pro Ser Phe Thr Gly Glu 
    50                  55                  60                  


Lys Thr Ala Gly Pro Asn Ala Asn Ser Ala Glu Val Glu Ser Cys Arg 
65                  70                  75                  80  


Ser Leu Ser Trp Cys Ser Pro Tyr 
                85              


<210>  168
<211>  178
<212>  PRT
<213>  Artemisia annua

<400>  168

Met Asp Gly Asp Ile Thr Leu Ile Asp Ser Lys Glu Val Thr Glu Glu 
1               5                   10                  15      


Val Val Glu Leu His Val Glu Thr Asp Val Glu Val Ala Gly Gly Lys 
            20                  25                  30          


Ile Ala Glu Thr Leu Phe Thr Ala Ala Asp Leu Gly Ser Asn Glu Val 
        35                  40                  45              


Asp Met Val Ser Pro Thr Leu Thr Leu Leu Gln Leu Leu Pro Asp Thr 
    50                  55                  60                  


Thr Ile Lys Ala Leu Leu Leu Arg Val Ser Ser His Asp Phe Tyr Ser 
65                  70                  75                  80  


Arg Thr Cys Pro Asn Val Phe Glu Ala Val Gly Ser Val Val Arg Ser 
                85                  90                  95      


Ala Val Ser Arg Glu Lys Arg Met Gly Ala Ser Leu Leu Arg Leu His 
            100                 105                 110         


Phe His Asp Tyr Phe Val Asn Gly Cys Asp Gly Ser Val Leu Leu Asp 
        115                 120                 125             


Asp Thr Pro Ser Phe Thr Gly Glu Lys Thr Ala Gly Pro Asn Ala Asn 
    130                 135                 140                 


Ser Ala Arg Gly Cys Asp Gly Ser Val Leu Leu Asp Asp Thr Pro Ser 
145                 150                 155                 160 


Phe Thr Gly Glu Lys Thr Ala Gly Pro Asn Ala Asn Ser Ala Arg Val 
                165                 170                 175     


Leu Thr 
        


<210>  169
<211>  432
<212>  PRT
<213>  Artemisia annua

<400>  169

Met Asp Gly Asp Ile Thr Leu Ile Asp Ser Lys Glu Val Thr Glu Glu 
1               5                   10                  15      


Val Val Glu Leu His Val Glu Thr Val Val Glu Val Ala Gly Gly Lys 
            20                  25                  30          


Ile Ala Glu Thr Leu Phe Thr Ala Ala Asp Leu Gly Ser Asn Glu Val 
        35                  40                  45              


Asp Met Val Ser Pro Thr Leu Thr Leu Leu Gln Leu Leu Pro Ala Thr 
    50                  55                  60                  


Thr Ile Lys Val Gly Ser Val Ile Arg Ser Ala Val Ser Arg Glu Lys 
65                  70                  75                  80  


Arg Met Gly Ala Ser Leu Leu Arg Leu His Phe His Asp Cys Phe Val 
                85                  90                  95      


Asn Gly Cys Asp Gly Ser Val Leu Leu Asp Asp Thr Pro Ser Phe Thr 
            100                 105                 110         


Gly Glu Lys Thr Ala Gly Pro Asn Ala Asn Ser Ala Arg Ser Lys Val 
        115                 120                 125             


Val Glu Val Cys Pro Gly Val Val Ser Cys Ala Asp Val Leu Ala Ile 
    130                 135                 140                 


Thr Ala Arg Gln Ser Val Val Ala Gly Gly Phe Leu Leu Asn Gly Ile 
145                 150                 155                 160 


Leu Leu Thr Arg Glu Tyr Val Gln His Gln Thr Met Ser Ser Gly Met 
                165                 170                 175     


Ala Ile Lys His Asp Lys Met Leu Leu Pro Ser Ile Ala Ala Pro Met 
            180                 185                 190         


Thr Glu Met Cys Gly Ser Gly Gln Gly Lys His Ile Ile Gln Val Leu 
        195                 200                 205             


Val Val Gly Arg Ile Tyr Asp Phe Gly Gln Gln Arg Ile Leu Lys Ile 
    210                 215                 220                 


Ser Thr Ile Lys Tyr Ala Ile Gln Thr Leu Val Arg Lys Ser Ser Ala 
225                 230                 235                 240 


Cys Glu Thr Met Gly Ser Leu Thr Val Ile Cys Thr Asp Lys Thr Gly 
                245                 250                 255     


Thr Leu Thr Leu Asn Gln Met Lys Gly Ile Met Ala Ala Cys Gly Tyr 
            260                 265                 270         


Ser His Ala Cys Gly Leu Asn Cys Asn Trp Gln Thr Cys Phe Ile Leu 
        275                 280                 285             


Leu Gln Leu Ser Tyr Lys Ser Arg Val Thr Trp Thr Glu Glu Glu His 
    290                 295                 300                 


Arg Ser Phe Leu Ile Gly Leu Glu Lys Leu Gly Lys Gly Asp Trp Arg 
305                 310                 315                 320 


Gly Ile Ser Lys Asn Tyr Val Pro Ser Arg Thr Pro Thr Gln Ser Ala 
                325                 330                 335     


Val Thr Pro Val Thr Thr Val Arg Pro Pro Val Ala Pro Ile Phe Arg 
            340                 345                 350         


Ser Asp Ser Ile Glu Asn Phe Asn Arg Leu Ser Tyr Ala Ala Ser Phe 
        355                 360                 365             


Leu Ile Tyr Gln Met Tyr Asp Leu Ser His Cys Leu Ser Ser Phe Leu 
    370                 375                 380                 


Tyr Tyr His Arg Leu Gln Asp Ala Asn Ser Asn Gly Thr Glu Ile Leu 
385                 390                 395                 400 


Gln Ser Phe Ile Leu Thr Gln Gln Tyr Val Asp Ser Val Leu Gly Tyr 
                405                 410                 415     


Glu Arg Glu Lys Met Lys Cys Cys Glu Ile Lys Tyr Lys Ser Pro Asn 
            420                 425                 430         


<210>  170
<211>  84
<212>  PRT
<213>  Artemisia annua

<400>  170

Met Asp Pro Gly Ser Arg Lys Thr Phe Asp Leu Ser Tyr Asn Ser Leu 
1               5                   10                  15      


Leu Leu Lys Gln Arg Val Leu Phe Glu Ser Asp Ser Ala Leu Thr Arg 
            20                  25                  30          


Asn Ser Ile Thr Leu Thr Tyr Ile Asn Gln Leu Leu Gln Gly Ser Leu 
        35                  40                  45              


Gln Asn Phe Phe Ser Glu Phe Ala Leu Ser Met Glu Lys Met Asn Glu 
    50                  55                  60                  


Ile Glu Val Lys Thr Gly Thr Ser Gly Glu Ile Arg Arg Asn Cys Ala 
65                  70                  75                  80  


Val Val Asn Asn 
                


<210>  171
<211>  64
<212>  PRT
<213>  Artemisia annua

<400>  171

Met Gly Asp Val Asp Leu Ser Tyr Asn Arg Arg Val Phe Asp Asn Val 
1               5                   10                  15      


Tyr Phe Gln Asn Leu Pro Lys Gly Leu Gly Val Leu Lys Ser Asp Arg 
            20                  25                  30          


Gly Leu Val Met Asn Lys Arg Thr Arg Gly Tyr Val Glu Trp Tyr Ala 
        35                  40                  45              


Thr Asp Gln Lys Ala Phe Phe Arg His Leu Gly Arg Arg Trp Arg Ser 
    50                  55                  60                  


<210>  172
<211>  124
<212>  PRT
<213>  Artemisia annua

<400>  172

Met Ala Ile Met Ser Ala Leu Leu Thr Ser Leu Leu Ile Leu Ser Phe 
1               5                   10                  15      


Leu Ser Arg Gly Thr Ser Leu Ser Ser Lys Tyr Tyr Glu Lys Thr Cys 
            20                  25                  30          


Pro Asn Ala Glu Ser Leu Ile Arg Lys Ala Val Arg Asp Val Val Thr 
        35                  40                  45              


Lys Asp Lys Lys Val Pro Ala Glu Leu Leu Arg Met His Phe His Asp 
    50                  55                  60                  


Arg Phe Ile Arg Val Ser Arg Ile Pro His Cys Ser Lys Thr Glu Ser 
65                  70                  75                  80  


Thr Thr Ser Thr Pro Gln Trp Met Leu Thr Arg Gln Ser Gly Leu His 
                85                  90                  95      


Phe Leu Lys Phe Lys Glu His Leu Pro Ser Gln Glu Gln Cys Lys Glu 
            100                 105                 110         


Cys Arg Cys Ser Asn Gly Ser Phe Phe Asn Lys Phe 
        115                 120                 


<210>  173
<211>  187
<212>  PRT
<213>  Artemisia annua

<400>  173

Met Thr Phe Leu Tyr Leu Phe Val Phe Leu Met Phe Ser Thr Ala Thr 
1               5                   10                  15      


Ala Cys Leu Asp Ser Val Leu Ser Thr Arg Tyr Tyr Asp His Val Cys 
            20                  25                  30          


Pro Glu Ala Leu Pro Thr Ile Lys Arg Val Val Glu Asp Ala Val Ala 
        35                  40                  45              


Gln Glu Arg Arg Met Gly Ala Ser Leu Leu Arg Leu Gln Phe His Asp 
    50                  55                  60                  


Cys Phe Val Asn Gly Ala His Thr Leu Gly Leu Ala Asp Glu Cys Arg 
65                  70                  75                  80  


Phe Leu Arg Pro His Ile Tyr Asn Asp Thr Asn Ile Asp Pro Ala Phe 
                85                  90                  95      


Gln Pro Ser Pro Ser Val Thr Ile Cys Pro Arg Val Glu Gly Asp Ser 
            100                 105                 110         


Asn Leu Thr Pro Leu Asp Ser Thr Ser Gly Ser Phe Asp Glu Lys Tyr 
        115                 120                 125             


Phe Pro Asn Leu Val Ser Lys Arg Gly Val Leu Arg Ser Tyr Gln Val 
    130                 135                 140                 


Leu Phe Asn Asp Ser Glu Thr Asp Lys Ile Val Ser Arg Tyr Tyr Glu 
145                 150                 155                 160 


Asp Gln Lys Lys Phe Phe Lys Asp Phe Ala Lys Ser Met Ile Arg Met 
                165                 170                 175     


Gly Asp Ile Asn Pro Leu Thr Gly Asn Arg Gly 
            180                 185         


<210>  174
<211>  137
<212>  PRT
<213>  Artemisia annua

<400>  174

Met Leu Val Pro Asp Pro Glu Gly Lys Leu Pro Glu Glu Thr Leu Asp 
1               5                   10                  15      


Ala Phe Gly Leu Lys Gln Ser Phe Gln Arg Lys Gly Phe Ser Thr Gln 
            20                  25                  30          


Glu Leu Val Ala Leu Ser Gly Ala His Thr Leu Gly Ser Lys Gly Phe 
        35                  40                  45              


Gly Asn Ser Val Val Phe Asp Asn Ala Tyr Tyr Lys Val Leu Leu Glu 
    50                  55                  60                  


Lys Pro Trp Gln Ser Ser Ala Gly Met Thr Ala Met Val Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Ala Leu Ile Glu Asp Asp Glu Cys Leu Arg Trp Ile Ser 
                85                  90                  95      


Lys Tyr Ala Glu Asp Gln Glu Leu Phe Phe Glu Asp Phe Lys Asn Ala 
            100                 105                 110         


Tyr Ile Lys Leu Val Asp Ser Gly Ala Lys Met Glu Lys Gly Leu Ile 
        115                 120                 125             


Val Pro Thr Phe Asp Ile Ile Thr Leu 
    130                 135         


<210>  175
<211>  206
<212>  PRT
<213>  Artemisia annua

<400>  175

Met Gly Lys Ile Tyr Pro Val Ile Thr Glu Glu Tyr Arg Leu Ala Leu 
1               5                   10                  15      


Glu Ala Ala Lys Pro Lys Leu Lys Ala Phe Leu Thr Glu Ser Gly Ser 
            20                  25                  30          


Ala Pro Leu Met Leu Arg Leu Ala Phe His Thr Ala Gly Thr Phe Asp 
        35                  40                  45              


Val Lys Thr Arg Thr Gly Gly Pro Phe Gly Thr Ile Arg Gln Lys Glu 
    50                  55                  60                  


Glu Gln Ala His Gly Ala Asn Val Gly Leu Asp Val Ala Ile Asn Met 
65                  70                  75                  80  


Leu Asp Pro Leu Arg Gln Glu Phe Ser Ile Leu Ser Trp Gly Asp Phe 
                85                  90                  95      


Leu Met Leu Val Gly Ala Leu Ala Val Glu Val Thr Gly Gly Pro Ile 
            100                 105                 110         


Val Pro Phe His Pro Gly Arg Pro Gly Ser Gly His Lys Asp Lys Ser 
        115                 120                 125             


Gly Phe Glu Gly Ser Trp Thr Ser Asn Pro Leu Val Phe Asp Asn Ser 
    130                 135                 140                 


Tyr Tyr Lys Glu Leu Leu Ala Gly Glu Lys Ala Gly Leu Leu Lys Leu 
145                 150                 155                 160 


Pro Ser Asp Lys Ala Leu Leu Ala Asp Pro Ile Phe Arg Pro Leu Val 
                165                 170                 175     


Glu Lys Phe Ala Ala Asp Gln Asn Ala Phe Phe Gln Ala Tyr Ser Glu 
            180                 185                 190         


Ser Tyr Met Lys Leu Ser Glu Leu Gly Trp Ala Asp Ile Pro 
        195                 200                 205     


<210>  176
<211>  355
<212>  PRT
<213>  Artemisia annua

<400>  176

Met Ala Leu Thr Met Phe Asn Leu Asn Lys Ser Leu Gly Phe Val Gly 
1               5                   10                  15      


Ala Leu Met Glu Arg Val Phe Gly Thr Asn Leu Phe Asp Thr Asn Leu 
            20                  25                  30          


Ala Leu Ser Ile Tyr Thr Val His Arg Phe Val Leu Ile Ala His Thr 
        35                  40                  45              


Asn Arg Glu Val Ala Gln Val Gly Leu Ser Val Pro Pro Arg Leu Ser 
    50                  55                  60                  


Thr Ile Ser Thr Glu Ala Cys Asn Glu Tyr Val Gln Ile Gly Lys Lys 
65                  70                  75                  80  


Leu Pro Ser Gly Leu Trp Asp Glu Ile Leu Glu Gly Leu Gln Tyr Val 
                85                  90                  95      


Gln Gln Glu Leu Gly Ser Ser Leu Gly Asp Leu Thr Lys Pro Leu Leu 
            100                 105                 110         


Ile Ser Val Arg Ser Gly Val Val Leu Leu Tyr Ile Thr Phe Gly Ile 
        115                 120                 125             


Met Val Leu Leu Lys Asn Ser Lys Lys Glu Thr Pro Glu Leu Lys Ser 
    130                 135                 140                 


Glu Ser Lys Cys Ile Asn Asp Cys Asn Leu Ile Thr Ser Phe Asp Cys 
145                 150                 155                 160 


Ala Asn Ile Leu Lys Asn Gly Phe Arg Asn Asp Asp Leu Met Val Val 
                165                 170                 175     


Ala Asp Val Ser Ser Gly Asp Cys Arg Lys Phe Asn Val Ala Ile Leu 
            180                 185                 190         


Thr Cys Phe Leu Gly Asn Gly Gln Leu Gly Trp Val Leu Ser Gln Ala 
        195                 200                 205             


Gly Thr Leu Gly Gly Pro Ser Trp Lys Val Lys Leu Gly Arg Arg Asp 
    210                 215                 220                 


Ser Glu Thr Ala Ser Arg Ala Asn Ala Asn Ala Asn Leu Pro Ser Pro 
225                 230                 235                 240 


Phe Met Asp Leu Pro Ser Asp Val Lys Ser Val Thr Ile Ala Gly Glu 
                245                 250                 255     


Leu Thr His Cys Phe Ile Trp Pro Glu His His Met Thr Asp Ile Ile 
            260                 265                 270         


Val Pro Val Leu Glu Glu Val Leu His Glu Thr Lys Val Glu Asp Thr 
        275                 280                 285             


Trp Lys Ala Leu Thr Asn Val Ile Ala Ile Gly Ile Gly Glu Ser Phe 
    290                 295                 300                 


Leu Gly Pro Leu Phe Val His Thr Ala Leu Pro Thr Val Glu Thr Val 
305                 310                 315                 320 


Gln Leu Thr Asp Asn Ser Pro Arg Arg Ser Arg Phe Cys Val Ser Val 
                325                 330                 335     


Gly His Ser Leu Leu Glu Trp Leu Ile His Ser Leu Ala Tyr Lys Ile 
            340                 345                 350         


Val Cys Leu 
        355 


<210>  177
<211>  450
<212>  PRT
<213>  Artemisia annua

<400>  177

Met Thr Ala His His Arg Ile Leu Ile Val Val Phe Pro Gly Gln Gly 
1               5                   10                  15      


His Ile Asn Pro Ser Leu Gln Phe Ala Lys Arg Ile Leu Ser Met Gly 
            20                  25                  30          


Val Glu Glu Val Thr Phe Cys Thr Asn Met Ser Val Val Arg Arg Ile 
        35                  40                  45              


Glu Lys Gln Thr Thr His His Gly Leu Thr Phe Ala Pro Ile Ser Glu 
    50                  55                  60                  


Asn Asp Pro Lys Pro Asn Glu Thr Leu Glu Gln Phe Cys Ser Asp Phe 
65                  70                  75                  80  


Ala Thr Asn Gly Ala Pro Ala Val Ser Asp Ile Ile Lys Ser Ala Ala 
                85                  90                  95      


Ala Ser Gly Asn Pro Phe Asp His Leu Val Tyr Thr Thr Ile Val Pro 
            100                 105                 110         


Trp Ala Ala Gly Val Ala Lys Ala His Gly Ile Lys Ser Thr Leu Leu 
        115                 120                 125             


Trp Cys Gln Ser Ala Thr Ile Leu Asp Leu Tyr Tyr Tyr Tyr Phe Asn 
    130                 135                 140                 


Gly Phe Gly Asp Leu Ile Ser Cys Ser Asn Lys Asn Pro Ser Phe Ala 
145                 150                 155                 160 


Ile Thr Leu Pro Gly Leu Pro Pro Leu Asn Thr Cys Asp Leu Pro Thr 
                165                 170                 175     


Phe Phe Leu Pro Ser Arg Pro Gln Glu His Asp Phe Ala Ile Pro Leu 
            180                 185                 190         


Phe Lys Asp His Ile Asp Val Leu Gly Glu Asn Pro Arg Val Leu Ile 
        195                 200                 205             


Ser Thr Phe Asn Glu Leu Glu Val Glu Pro Ile Arg Ala Leu Lys Asn 
    210                 215                 220                 


Leu Glu Leu Leu Pro Val Gly Pro Leu Ile Pro Ser Ala Phe Leu Asp 
225                 230                 235                 240 


Gly Gln Asp Pro Ser Asp Asn Ser Phe Gly Gly Asp Leu Phe Glu Lys 
                245                 250                 255     


Ser Val Glu Asp Tyr Ile Lys Trp Leu Asn Thr Lys Pro Lys Ser Ser 
            260                 265                 270         


Val Val Tyr Val Ser Phe Gly Ser Met Ser Thr Leu Ser Phe Asp Gln 
        275                 280                 285             


Ala Glu Glu Met Ala Asn Gly Leu Leu Glu Ser Gly Arg Pro Phe Leu 
    290                 295                 300                 


Trp Val Ile Arg Asp Gly Gly Glu Thr Leu Glu Val Ser Lys Ile Glu 
305                 310                 315                 320 


Glu Met Lys Lys Gln Gly Met Ile Val Gly Trp Cys Ser Gln Val Glu 
                325                 330                 335     


Val Leu Ser His Gln Ala Ile Gly Cys Phe Val Ser His Cys Gly Trp 
            340                 345                 350         


Asn Ser Thr Val Glu Ala Leu Ala Ala Gly Val Pro Thr Val Ala Phe 
        355                 360                 365             


Pro Gln Trp Thr Asp Gln Gly Thr Asn Ala Lys Met Ile Glu Asp Val 
    370                 375                 380                 


Trp Lys Thr Gly Val Arg Val Arg Lys Arg Glu Gly His Glu Val Val 
385                 390                 395                 400 


Asp Gly Lys Glu Ile Glu Arg Cys Val Lys Met Val Met Gly Asn Glu 
                405                 410                 415     


Glu Met Arg Arg Asn Ala Glu Lys Trp Lys Asp Leu Ala Arg Lys Ala 
            420                 425                 430         


Val Asn Asn Gly Gly Ser Ser Thr Ile Asn Leu Gln Ala Phe Leu Asp 
        435                 440                 445             


Asp Ala 
    450 


<210>  178
<211>  1437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  178

Met Asn Ser Pro Gln Ala Ile Ile His Leu Ser Ser Ser Ser Leu Ile 
1               5                   10                  15      


Ser Phe Leu Ala Ile Thr Cys Leu Thr Ser Ala Thr Val Cys Ala Ser 
            20                  25                  30          


Tyr Gly Gly Leu Glu Gly Ser Leu Ser Pro His Val Gly Asn Leu Ser 
        35                  40                  45              


Phe Leu Arg Asn Leu Ser Leu Trp Asn Asn Ser Phe Gln Gly Thr Ile 
    50                  55                  60                  


Pro His Glu Leu Gly Arg Leu Ser Arg Leu Arg His Leu Phe Leu Ala 
65                  70                  75                  80  


Glu Asn Asn Phe Asn Gly Val Ile Pro Thr Asn Leu Ser Gly Cys Ser 
                85                  90                  95      


Asn Leu Glu Gln Leu Trp Leu Ala Glu Asn Lys Leu Thr Gly Ser Ile 
            100                 105                 110         


Pro Lys Glu Met Ser Leu Leu Ser Lys Leu Val Tyr Leu Gly Ile His 
        115                 120                 125             


Asp Asn Lys Leu Thr Gly Gly Ile Pro Pro Phe Phe Gly Asn Ile Thr 
    130                 135                 140                 


Ser Met Glu Val Phe Ser Ala Arg Arg Asn Pro Leu Gly Gly Ser Ile 
145                 150                 155                 160 


Pro Asp Thr Leu Gly His Trp Lys Ser Leu Thr His Phe Tyr Ser Gly 
                165                 170                 175     


Gly Cys Asn Leu Tyr Gly Ser Ile Pro His Ser Ile Phe Asn Leu Ser 
            180                 185                 190         


Leu Leu Val Asn Leu Ser Leu Ser Thr Asn His Leu Thr Gly Ser Leu 
        195                 200                 205             


Pro Leu Glu Ile Gly Asn Gln Leu Pro Asn Leu Glu Phe Leu Gln Leu 
    210                 215                 220                 


Arg Asn Asn Lys Leu Thr Gly Val Leu Pro Pro Ser Ile Ser Asn Cys 
225                 230                 235                 240 


Ser Lys Leu Gly Phe Leu Glu Met Ser Ser Asn Asn Phe Ser Arg Lys 
                245                 250                 255     


Leu Thr Ile Asp Phe Ser Lys Leu Arg Asp Ile Tyr Lys Ile Asn Leu 
            260                 265                 270         


His Asp Asn Asn Phe His Gly Ser Gly Glu Ala Asp Asp Met Arg Phe 
        275                 280                 285             


Ile Asn Ser Leu Lys Asn Cys Thr Lys Leu Val Thr Leu Gln Leu Tyr 
    290                 295                 300                 


Asn Cys Asn Leu Arg Gly Val Leu Pro Ile Ser Ile Gly Asn Leu Ser 
305                 310                 315                 320 


His Gln Leu Ser Leu Leu Gly Leu Gly Gly Asn Gln Leu Phe Gly Ser 
                325                 330                 335     


Leu Pro Ser Ser Ile Gly Gly His Ile Pro Ser Ser Ile Gly Asn Cys 
            340                 345                 350         


Lys Gln Leu Asn Gly Leu Tyr Leu Ala Asn Asn Arg Leu Ser Gly Asn 
        355                 360                 365             


Ile Pro Lys Gln Leu Phe Gln Leu Pro Ser Leu Asn Asn Phe Leu Ile 
    370                 375                 380                 


Leu Ser Gln Asn Ser Leu Ser Gly Ser Ile Pro Ser Glu Ile Thr Asn 
385                 390                 395                 400 


Leu Lys Thr Leu Ser Tyr Leu Asp Leu Ser Tyr Asn Asn Leu Ser Gly 
                405                 410                 415     


Asn Ile Thr Ser Asn Leu Gly Glu Cys Val Ser Leu Thr Thr Leu Asn 
            420                 425                 430         


Leu Arg Gly Asn Arg Phe Gln Gly Val Ile Pro Ser Ser Phe Ser Ser 
        435                 440                 445             


Leu Gly Gly Leu Gly Val Leu Asp Ile Ser Glu Asn Asn Leu Ser Gly 
    450                 455                 460                 


Arg Ile Pro Gln Phe Leu Gly Lys Trp Lys Ser Leu Glu Tyr Leu Asn 
465                 470                 475                 480 


Leu Ser Phe Asn Asp Phe Glu Gly Glu Val Pro Val Glu Gly Val Phe 
                485                 490                 495     


Ala Asn Ala Ser Leu Phe Ser Val Leu Gly Asn Asp Lys Leu Cys Gly 
            500                 505                 510         


Gly Leu Lys Arg Val Thr Ala Leu Arg Leu Val Ser Gln Gly Leu Glu 
        515                 520                 525             


Gly Ser Leu Ser Pro His Val Gly Asn Leu Ser Phe Leu Arg Glu Ile 
    530                 535                 540                 


Ser Leu Trp Asn Asn Ser Phe Gln Gly Thr Ile Pro His Glu Leu Gly 
545                 550                 555                 560 


Arg Leu Ser Arg Leu Arg Gly Leu Tyr Leu Ser Ile Asn Lys Phe Ser 
                565                 570                 575     


Gly Val Ile Pro Thr Asn Leu Ser Gly Cys Ser Asn Leu Glu His Leu 
            580                 585                 590         


Trp Leu Tyr Lys Asn Glu Leu Thr Gly Ser Ile Pro Lys Glu Met Ser 
        595                 600                 605             


Leu Leu Ser Lys Leu Val Tyr Leu Gly Ile Asp Asp Asn Lys Leu Thr 
    610                 615                 620                 


Gly Gly Ile Pro Pro Phe Leu Gly Asn Ile Thr Ser Met Glu Trp Phe 
625                 630                 635                 640 


Tyr Ala Ser Gly Asn Leu Leu Gly Gly Asn Ile Pro Asp Thr Leu Gly 
                645                 650                 655     


Leu Trp Lys Asn Leu Thr Glu Phe Val Cys Gly Gly Cys Asn Leu Tyr 
            660                 665                 670         


Gly Ser Ile Pro His Ser Ile Phe Asn Leu Ser Leu Leu Val Asn Phe 
        675                 680                 685             


Ser Leu Pro Ile Asn His Leu Thr Gly Ser Leu Pro Ser Glu Ile Gly 
    690                 695                 700                 


Asn Gln Leu Pro Asn Leu Glu Leu Leu Gln Leu Trp Gly Asn Glu Leu 
705                 710                 715                 720 


Thr Gly Val Leu Pro Pro Ser Leu Ser Asn Cys Ser Lys Leu Gly Tyr 
                725                 730                 735     


Phe Glu Met Ser Asp Asn Asn Phe Ser Gly Lys Leu Thr Ile Asp Phe 
            740                 745                 750         


Ser Lys Leu Arg Asp Ile Tyr Ile Ile Gly Leu Tyr Asp Asn Asn Phe 
        755                 760                 765             


His Gly Arg Gly Glu Ala Asp Asp Leu Arg Phe Val Asp Ser Leu Lys 
    770                 775                 780                 


Asn Cys Thr Arg Leu Ala Val Leu Glu Leu Ser Ser Cys Asn Leu Arg 
785                 790                 795                 800 


Gly Val Leu Pro Ile Ser Ile Gly Asn Leu Ser Lys Gln Leu Glu Phe 
                805                 810                 815     


Leu His Leu Gly Gly Asn Gln Leu Phe Gly Asn Leu Pro Ser Ser Ile 
            820                 825                 830         


Gly Ser Leu Val Gly Leu Thr Thr Leu Ser Leu Glu Asn Asn Arg Phe 
        835                 840                 845             


Lys Gly Asn Ile Pro Thr Ser Val Gly Lys Leu Gln Lys Leu Gln Ala 
    850                 855                 860                 


Leu Gly Leu Asp Arg Asn His Phe Ser Gly Pro Ile Pro Asp Ala Ile 
865                 870                 875                 880 


Arg Asn Leu Ser Leu Leu Asn Lys Leu Tyr Leu Asn Phe Asn Lys Leu 
                885                 890                 895     


Glu Gly His Ile Pro Ser Ser Leu Gly Asn Cys Lys Glu Leu Ile Gly 
            900                 905                 910         


Leu Asn Leu Ala Asp Asn Arg Phe Thr Gly Lys Ile Pro Lys Gln Leu 
        915                 920                 925             


Leu Gln Leu Pro Ser Leu Thr Tyr Phe Phe Asn Leu Ser His Asn Lys 
    930                 935                 940                 


Met Ser Gly Ser Ile Pro Ser Glu Ile Lys Asp Leu Lys Thr Leu Ser 
945                 950                 955                 960 


Tyr Leu Asp Leu Ser Tyr Asn Asn Leu Ser Gly Asn Ile Thr Ser Asn 
                965                 970                 975     


Leu Gly Glu Cys Met Ser Leu Thr Thr Leu Lys Leu Arg Gly Asn Arg 
            980                 985                 990         


Phe Gln Gly Val Ile Pro Ser Ser  Phe Ser Ser Leu Gly  Gly Leu Gly 
        995                 1000                 1005             


Val Leu  Asp Ile Ser Glu Asn  Asn Leu Ser Gly Arg  Ile Pro Gln 
    1010                 1015                 1020             


Phe Phe  Gly Lys Trp Lys Ser  Leu Glu Phe Leu Asn  Leu Ser Phe 
    1025                 1030                 1035             


Asn Asp  Phe Glu Gly Glu Val  Pro Val Glu Gly Val  Phe Ala Asn 
    1040                 1045                 1050             


Ala Ser  Leu Phe Ser Val Leu  Gly Asn Asp Lys Leu  Cys Gly Gly 
    1055                 1060                 1065             


Leu Val  Thr Leu Gly Leu Pro  Lys Cys Lys Glu Thr  Gly Ser Lys 
    1070                 1075                 1080             


Lys Lys  Arg Phe Pro Phe Phe  Ile Phe Val Met Val  Ser Ala Pro 
    1085                 1090                 1095             


Thr Leu  Leu Ile Val Leu Cys  Cys Val Tyr Leu Leu  Cys Lys Lys 
    1100                 1105                 1110             


Lys Gln  Asn Ser Gln Gln Ser  Gln Ser Ser Arg Ser  Glu Arg Phe 
    1115                 1120                 1125             


Met Lys  Val Ser Tyr Gly Gln  Leu Leu Lys Ala Thr  Asp Gly Phe 
    1130                 1135                 1140             


Ser Gly  Ala Asn Leu Ile Gly  Gln Gly Gly Phe Ser  Ser Val Tyr 
    1145                 1150                 1155             


Arg Gly  Ile Leu Asn Ser Asp  Asp Asp Lys Ser Val  Ala Ile Lys 
    1160                 1165                 1170             


Val Leu  His Leu Gln Asn Arg  Gly Ala Gln Lys Ser  Phe Val Ala 
    1175                 1180                 1185             


Glu Cys  Glu Ala Trp Pro Asn  Ile Arg His Arg Asn  Leu Leu Lys 
    1190                 1195                 1200             


Ile Ile  Thr Ser Cys Ser Ser  Thr Asp Phe Gln Gly  Asn Asp Phe 
    1205                 1210                 1215             


Lys Ala  Leu Val Tyr Glu Phe  Met Pro Asn Gly Ser  Val His Asp 
    1220                 1225                 1230             


Trp Leu  His Ser Ser Ala Asn  Thr Ser Lys Leu Asn  Leu Leu Gln 
    1235                 1240                 1245             


Arg Ile  Asn Ile Leu Arg Asp  Val Ala Thr Ala Leu  Asp Tyr Leu 
    1250                 1255                 1260             


His Asn  Arg Cys Gln Thr Thr  Ile Val His Gly Asp  Leu Lys Pro 
    1265                 1270                 1275             


Ser Asn  Ile Leu Leu Asp Ala  Asp Met Val Ala His  Val Gly Asp 
    1280                 1285                 1290             


Phe Gly  Leu Ala His Leu Ile  Gly Thr Asp Leu Asn  Gln Tyr Ser 
    1295                 1300                 1305             


Ser Thr  Gly Val Lys Gly Thr  Ile Gly Tyr Ala Pro  Pro Glu Tyr 
    1310                 1315                 1320             


Gly Leu  Gly Ser Glu Met Thr  Ser Ile Gly Asp Val  Tyr Ser Phe 
    1325                 1330                 1335             


Gly Ile  Leu Leu Leu Glu Val  Met Thr Gly Lys Arg  Pro Thr Asp 
    1340                 1345                 1350             


Asp Met  Phe Ser Asp Gly Leu  Ser Leu His Lys Phe  Ala Tyr Met 
    1355                 1360                 1365             


Ala Leu  Thr Asp His Val Ile  Asp Val Val Asp Gly  Asp Ala Ile 
    1370                 1375                 1380             


Leu Leu  Gln Ser Met Glu Ala  Asn Ala Lys Lys Val  Glu Glu Cys 
    1385                 1390                 1395             


Leu Val  Ala Thr Ile Lys Ile  Gly Val Ser Cys Ser  Val Asp Ser 
    1400                 1405                 1410             


Pro Pro  Gln Arg Met Lys Ile  Glu Ile Val Val Asn  Glu Leu Gln 
    1415                 1420                 1425             


Arg Ile  Leu Asp Val Leu Gln  Asn Ile 
    1430                 1435         


<210>  179
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  179

Met Val Val Leu Phe Asn Asn Lys Lys Pro Ile Leu Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Ile Thr Leu Ser Leu Gly Gln Gly Thr Arg Leu Gly 
            20                  25                  30          


Phe Tyr Arg Thr Ser Cys Pro Arg Val Glu Ser Ile Val Gln Asn Ala 
        35                  40                  45              


Val Asn Ser Ala Val Arg Ala Asn Pro Thr Ile Ala Pro Gly Leu Leu 
    50                  55                  60                  


Arg Met Phe Phe His Asp Cys Phe Val Asn Gly Cys Asp Ala Ser Ile 
65                  70                  75                  80  


Leu Ile Asp Gly Ala Ser Ser Glu Lys Thr Ala Arg Pro Asn Ser Leu 
                85                  90                  95      


Leu Arg Gly Phe Glu Val Ile Asp Ala Ala Lys Arg Gln Leu Glu Ile 
            100                 105                 110         


Ala Cys Pro Arg Val Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala 
        115                 120                 125             


Arg Asp Ser Val Val Gln Thr Gly Gly Thr Gly Trp Ser Val Pro Leu 
    130                 135                 140                 


Gly Arg Lys Asp Gly Leu Val Ser Arg Ala Ala Asp Thr Ala Asn Leu 
145                 150                 155                 160 


Pro Ala Phe Asn Asp Pro Ile Asn Val Gln Ile Arg Lys Phe Thr Asp 
                165                 170                 175     


Lys Gly Leu Asn Thr Gln Asp Leu Val Ala Leu Ser Gly Ala His Thr 
            180                 185                 190         


Ile Gly Thr Ala Ala Cys Ala Leu Phe Ser Tyr Arg Leu Tyr Asn Tyr 
        195                 200                 205             


Asn Asn Thr Asn Gly Pro Asp Pro Thr Ile Asp Ala Ser Phe Leu Pro 
    210                 215                 220                 


Thr Leu Arg Asn Leu Cys Pro Asn Gly Gly Asp Gly Thr Thr Arg Val 
225                 230                 235                 240 


Thr Leu Asp Thr Gly Ser Val Arg Asn Phe Asp Asn Ser Tyr Tyr Ser 
                245                 250                 255     


Asn Leu Arg Asn Arg Arg Gly Val Leu Glu Ser Asp Ala Ala Leu Trp 
            260                 265                 270         


Asn Asn Pro Ala Thr Gln Thr Leu Val Asn Arg Phe Leu Gly Leu Arg 
        275                 280                 285             


Gly Leu Leu Gly Leu Arg Phe Asn Ile Glu Phe Gly Arg Ser Met Val 
    290                 295                 300                 


Lys Met Gly Asn Ile Glu Val Lys Thr Gly Thr Gln Gly Glu Ile Arg 
305                 310                 315                 320 


Arg Val Cys Thr Ala Thr Asn 
                325         


<210>  180
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  180

Met Thr Met Ala Phe Ser Lys Ala Ser Cys Gln Thr Leu Ile Phe Ala 
1               5                   10                  15      


Leu Leu Leu Leu Cys Asn Leu Arg Ala Leu Glu Ala Gln Thr Pro Ala 
            20                  25                  30          


Pro Ala Pro Gly Leu Ser Tyr Thr Phe Tyr Arg Thr Thr Cys Pro Asn 
        35                  40                  45              


Leu Glu Thr Ile Ile Arg Gln Gln Leu Gln Thr Val Phe Ala Ser Asp 
    50                  55                  60                  


Ile Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His Asp Cys Phe 
65                  70                  75                  80  


Val Gln Gly Cys Asp Ala Ser Val Leu Leu Asp Gly Ser Ala Ser Gly 
                85                  90                  95      


Pro Ser Glu Lys Asp Ala Pro Pro Asn Leu Thr Leu Arg Ala Gln Ala 
            100                 105                 110         


Phe Val Ile Ile Glu Asn Leu Arg Arg Leu Val His Asn Ala Cys Asn 
        115                 120                 125             


Arg Thr Val Ser Cys Ala Asp Ile Thr Ala Leu Ala Ala Arg Asp Ala 
    130                 135                 140                 


Val Phe Leu Ser Gly Gly Pro Asn Tyr Ser Ile Pro Leu Gly Arg Arg 
145                 150                 155                 160 


Asp Gly Leu Thr Phe Ala Thr Val Asn Val Thr Leu Ala Asn Leu Pro 
                165                 170                 175     


Pro Pro Thr Ala Asn Ala Ser Thr Ile Leu Ser Ser Leu Ala Leu Lys 
            180                 185                 190         


Gly Phe Thr Pro Thr Asp Val Val Ser Leu Ser Gly Gly His Thr Ile 
        195                 200                 205             


Gly Ile Gly His Cys Gly Ser Phe Asn Asn Arg Ile Tyr Pro Ser Arg 
    210                 215                 220                 


Asp Pro Ser Met Asp Gln Thr Phe Phe Asn Asn Leu Arg Leu Thr Cys 
225                 230                 235                 240 


Pro Thr Asn Thr Ser Asn Asn Thr Thr Val Leu Asp Ile Arg Ser Pro 
                245                 250                 255     


Asn Val Phe Asp Asn Lys Tyr Tyr Val Asp Leu Met Asn Arg Gln Gly 
            260                 265                 270         


Leu Phe Thr Ser Asp Gln Asp Leu Tyr Thr Asp Ser Arg Thr Arg Thr 
        275                 280                 285             


Ile Val Thr Asn Phe Ala Val Asn Gln Thr Leu Phe Tyr Gln Asn Phe 
    290                 295                 300                 


Ile Asn Ala Met Ile Lys Met Gly Gln Leu Asn Val Leu Thr Gly Thr 
305                 310                 315                 320 


Gln Gly Glu Ile Arg Ala Asn Cys Ser Arg Arg Asn Ser Asn Asp Leu 
                325                 330                 335     


Phe Ile Leu Pro Thr Met Glu Asn Asp Gln Asp Glu Lys Val Ala Ser 
            340                 345                 350         


Tyr 
    


<210>  181
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  181

Met Ala Leu Lys His Leu Ile Phe Phe Thr Leu Leu Ser Ile Leu Ala 
1               5                   10                  15      


Ile Ser Ser Phe Ala Asp Thr Glu Ser Ser Thr Thr Thr Asp Ser Gly 
            20                  25                  30          


Leu Ala Leu Asn Phe Tyr Lys Asp Ser Cys Pro Gln Ala Glu Asp Ile 
        35                  40                  45              


Ile Arg Glu Gln Val Gly Leu Leu Tyr Lys Arg His Lys Asn Thr Ala 
    50                  55                  60                  


Phe Ser Trp Leu Arg Asn Ile Phe His Asp Cys Ala Val Glu Arg Cys 
65                  70                  75                  80  


Asp Ala Ser Leu Leu Leu Asp Ser Thr Arg Arg Gln Leu Ser Glu Lys 
                85                  90                  95      


Glu Thr Asp Arg Ser Phe Gly Leu Arg Asn Phe Arg Tyr Leu Glu Glu 
            100                 105                 110         


Ile Lys Glu Ala Val Glu Arg Glu Cys Pro Gly Val Val Ser Cys Ala 
        115                 120                 125             


Asp Ile Leu Val Leu Ser Gly Arg Asp Gly Ile Val Ala Val Gly Gly 
    130                 135                 140                 


Pro Tyr Ile Pro Leu Lys Thr Gly Arg Arg Asp Gly Arg Lys Ser Arg 
145                 150                 155                 160 


Ala Asp Ile Trp Ser Lys Leu Pro Asp His Asn Glu Arg Met Thr Val 
                165                 170                 175     


Val Leu Glu Arg Phe Lys Ser Ile Gly Ile Asp Thr Pro Gly Val Val 
            180                 185                 190         


Ala Leu Leu Gly Ser His Ser Val Gly Arg Thr His Cys Val Lys Leu 
        195                 200                 205             


Val His Arg Leu Tyr Pro Glu Val Asp Pro Ala Leu Asn Pro Gly His 
    210                 215                 220                 


Val Glu His Met Leu His Lys Cys Pro Asp Ala Ile Pro Asp Pro Lys 
225                 230                 235                 240 


Ala Val Gln Tyr Val Arg Asn Asp Arg Gly Thr Pro Met Lys Leu Asp 
                245                 250                 255     


Asn Asn Tyr Tyr Arg Asn Ile Leu Asp Asn Lys Gly Leu Leu Leu Val 
            260                 265                 270         


Asp His Gln Leu Ala Val Asp Lys Arg Thr Lys Pro Tyr Val Lys Lys 
        275                 280                 285             


Met Ala Lys Asn Gln Asp Tyr Phe Phe Lys Gln Phe Ala Arg Ala Ile 
    290                 295                 300                 


Thr Ile Leu Thr Glu Asn Asn Pro Leu Thr Gly Asn Glu Gly Glu Ile 
305                 310                 315                 320 


Arg Gln Gln Cys Asn Val Ala Asn Lys His His 
                325                 330     


<210>  182
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  182

Met Glu Tyr Tyr Tyr Asn Tyr Asn Ser Ile Asn Lys Met Val Ser Ile 
1               5                   10                  15      


Ile Phe Ile Leu Val Leu Ala Ile Asp Leu Thr Met Val Leu Gly Gln 
            20                  25                  30          


Gly Thr Arg Val Gly Phe Tyr Ser Ser Thr Cys Pro Arg Ala Glu Ser 
        35                  40                  45              


Ile Val Gln Ser Thr Val Arg Ser His Phe Gln Ser Asp Pro Thr Val 
    50                  55                  60                  


Ala Pro Gly Leu Leu Thr Met His Phe His Asp Cys Phe Val Gln Gly 
65                  70                  75                  80  


Cys Asp Ala Ser Ile Leu Ile Ser Gly Ser Gly Thr Glu Arg Thr Ala 
                85                  90                  95      


Pro Pro Asn Ser Leu Leu Arg Gly Tyr Glu Val Ile Asp Asp Ala Lys 
            100                 105                 110         


Gln Gln Ile Glu Ala Ile Cys Pro Gly Val Val Ser Cys Ala Asp Ile 
        115                 120                 125             


Leu Ala Leu Ala Ala Arg Asp Ser Val Leu Val Thr Lys Gly Leu Thr 
    130                 135                 140                 


Trp Ser Val Pro Thr Gly Arg Arg Asp Gly Leu Val Ser Arg Ala Ser 
145                 150                 155                 160 


Asp Thr Ser Asp Leu Pro Gly Phe Thr Glu Ser Val Asp Ser Gln Lys 
                165                 170                 175     


Gln Lys Phe Ser Ala Lys Gly Leu Asn Thr Gln Asp Leu Val Thr Leu 
            180                 185                 190         


Val Gly Gly His Thr Ile Gly Thr Ser Ala Cys Gln Phe Phe Ser Tyr 
        195                 200                 205             


Arg Leu Tyr Asn Phe Asn Ser Thr Gly Gly Pro Asp Pro Ser Ile Asp 
    210                 215                 220                 


Ala Ser Phe Leu Pro Thr Leu Arg Gly Leu Cys Pro Gln Asn Gly Asp 
225                 230                 235                 240 


Gly Ser Lys Arg Val Ala Leu Asp Thr Gly Ser Val Asn Asn Phe Asp 
                245                 250                 255     


Thr Ser Tyr Phe Ser Asn Leu Arg Asn Gly Arg Gly Ile Leu Glu Ser 
            260                 265                 270         


Asp Gln Lys Leu Trp Thr Asp Asp Ser Thr Lys Val Phe Ile Gln Arg 
        275                 280                 285             


Tyr Leu Gly Leu Arg Gly Phe Leu Gly Leu Arg Phe Gly Val Glu Phe 
    290                 295                 300                 


Gly Arg Ser Met Val Lys Met Ser Asn Ile Glu Val Lys Thr Gly Thr 
305                 310                 315                 320 


Asn Gly Glu Ile Arg Lys Val Cys Ser Ala Ile Asn 
                325                 330         


<210>  183
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  183

Met Ala Tyr Tyr Asn Tyr Asn Leu Ile Asn Lys Met Val Thr Ile Ile 
1               5                   10                  15      


Phe Ile Leu Val Leu Val Ile Val Asp Val Thr Met Val Phe Gly Gln 
            20                  25                  30          


Gly Thr Arg Val Gly Phe Tyr Ser Ser Thr Cys Pro Arg Ala Glu Ser 
        35                  40                  45              


Ile Val Gln Ser Thr Val Arg Ser His Phe Gln Ser Asp Pro Thr Val 
    50                  55                  60                  


Ala Pro Gly Leu Leu Arg Met His Phe His Asp Cys Phe Val Gln Gly 
65                  70                  75                  80  


Cys Asp Gly Ser Ile Leu Ile Ser Gly Thr Gly Thr Glu Arg Thr Ala 
                85                  90                  95      


Pro Pro Asn Ser Asn Leu Arg Gly Phe Glu Val Ile Asp Asp Ala Lys 
            100                 105                 110         


Gln Gln Ile Glu Ala Val Cys Pro Gly Val Val Ser Cys Ala Asp Ile 
        115                 120                 125             


Leu Ala Leu Ala Ala Arg Asp Ser Val Leu Val Thr Lys Gly Leu Thr 
    130                 135                 140                 


Trp Ser Val Pro Thr Gly Arg Thr Asp Gly Arg Val Ser Ser Ala Ser 
145                 150                 155                 160 


Asp Thr Ser Asn Leu Pro Gly Phe Thr Glu Ser Val Ala Ala Gln Lys 
                165                 170                 175     


Gln Lys Phe Ala Ala Lys Gly Leu Asn Thr Gln Asp Leu Val Thr Leu 
            180                 185                 190         


Val Gly Gly His Thr Ile Gly Thr Ser Ala Cys Gln Phe Phe Ser Tyr 
        195                 200                 205             


Arg Leu Tyr Asn Phe Asn Ser Thr Gly Gly Pro Asp Pro Ser Ile Asp 
    210                 215                 220                 


Ala Thr Phe Leu Ser Gln Leu Gln Ala Leu Cys Pro Gln Asn Gly Asp 
225                 230                 235                 240 


Gly Ser Lys Arg Val Ala Leu Asp Thr Gly Ser Val Asn Asn Phe Asp 
                245                 250                 255     


Thr Ser Tyr Phe Ser Asn Leu Arg Asn Gly Arg Gly Ile Leu Glu Ser 
            260                 265                 270         


Asp Gln Ile Leu Trp Thr Asp Ala Ser Thr Lys Val Phe Val Gln Arg 
        275                 280                 285             


Tyr Leu Gly Leu Arg Gly Phe Leu Gly Leu Arg Phe Gly Leu Glu Phe 
    290                 295                 300                 


Gly Lys Ser Met Val Lys Met Ser Asn Ile Glu Val Leu Thr Gly Thr 
305                 310                 315                 320 


Asn Gly Glu Ile Arg Lys Val Cys Ser Ala Phe Asn 
                325                 330         


<210>  184
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  184

Met Glu Tyr Tyr His His Ser Ile Asn Lys Met Ala Met Phe Met Val 
1               5                   10                  15      


Ile Leu Val Leu Ala Ile Asp Val Thr Met Val Leu Gly Gln Gly Thr 
            20                  25                  30          


Arg Val Gly Phe Tyr Ser Ser Thr Cys Pro Arg Ala Glu Ser Ile Val 
        35                  40                  45              


Gln Ser Thr Val Arg Ala His Phe Gln Ser Asp Pro Thr Val Ala Pro 
    50                  55                  60                  


Gly Ile Leu Arg Met His Phe His Asp Cys Phe Val Leu Gly Cys Asp 
65                  70                  75                  80  


Gly Ser Ile Leu Ile Glu Gly Ser Asp Ala Glu Arg Thr Ala Ile Pro 
                85                  90                  95      


Asn Arg Asn Leu Arg Gly Phe Asp Val Ile Glu Asp Ala Lys Lys Gln 
            100                 105                 110         


Ile Glu Ala Ile Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala 
        115                 120                 125             


Leu Ala Ala Arg Asp Ser Val Val Ala Thr Arg Gly Leu Thr Trp Ser 
    130                 135                 140                 


Val Pro Thr Gly Arg Arg Asp Gly Arg Val Ser Arg Ala Ala Asp Ala 
145                 150                 155                 160 


Gly Asn Leu Pro Ala Phe Phe Asp Ser Val Asp Val Gln Lys Gln Lys 
                165                 170                 175     


Phe Thr Ala Lys Gly Leu Asn Thr Gln Asp Leu Val Ala Leu Thr Gly 
            180                 185                 190         


Ala His Thr Ile Gly Thr Ala Gly Cys Ala Val Ile Arg Gly Arg Leu 
        195                 200                 205             


Phe Asn Phe Asn Ser Thr Gly Gly Pro Asp Pro Ser Ile Asp Ala Thr 
    210                 215                 220                 


Phe Leu Pro Gln Leu Gln Ala Leu Cys Pro Gln Asn Gly Asp Ala Ala 
225                 230                 235                 240 


Arg Arg Val Ala Leu Asp Thr Gly Ser Ala Asn Asn Phe Asp Thr Ser 
                245                 250                 255     


Tyr Phe Ser Asn Leu Arg Asn Gly Arg Gly Val Leu Glu Ser Asp Gln 
            260                 265                 270         


Lys Leu Trp Thr Asp Ala Ser Thr Lys Val Phe Val Gln Arg Phe Leu 
        275                 280                 285             


Gly Ile Arg Gly Leu Leu Gly Leu Thr Phe Gly Val Glu Phe Gly Arg 
    290                 295                 300                 


Ser Met Val Lys Met Ser Asn Ile Glu Val Lys Thr Gly Thr Asn Gly 
305                 310                 315                 320 


Glu Ile Arg Lys Val Cys Ser Ala Ile Asn 
                325                 330 


<210>  185
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  185

Met Asp Val Ser Cys Phe Ser Gln Asn Val Leu Leu Val Thr Leu Leu 
1               5                   10                  15      


Leu Ala Ile Ala Val Ser Leu Val Glu Ser Gln Gly Thr Arg Val Gly 
            20                  25                  30          


Phe Tyr Ser Thr Ser Cys Pro Arg Val Glu Ser Ile Val Arg Ser Thr 
        35                  40                  45              


Val Gln Ser His Phe Gly Ser Asp Pro Thr Ile Ala Pro Gly Leu Leu 
    50                  55                  60                  


Arg Met His Phe His Asp Cys Phe Val His Gly Cys Asp Ala Ser Ile 
65                  70                  75                  80  


Leu Ile Asp Gly Pro Gly Thr Glu Lys Thr Ala Pro Pro Asn Leu Leu 
                85                  90                  95      


Leu Arg Gly Tyr Glu Val Ile Asp Asp Ala Lys Thr Gln Leu Glu Ala 
            100                 105                 110         


Ala Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Ala Leu Ala Ala 
        115                 120                 125             


Arg Asp Ser Val Val Leu Ser Ser Gly Ala Ser Trp Ala Val Pro Thr 
    130                 135                 140                 


Gly Arg Arg Asp Gly Thr Val Ser Gln Ala Ser Asp Ala Ala Asn Leu 
145                 150                 155                 160 


Pro Gly Phe Arg Asp Ser Val Asp Val Gln Lys Gln Lys Phe Ala Ala 
                165                 170                 175     


Lys Gly Leu Asn Thr Gln Asp Leu Val Thr Leu Val Gly Gly His Thr 
            180                 185                 190         


Ile Gly Thr Thr Ala Cys Gln Phe Phe Arg Tyr Arg Leu Tyr Asn Phe 
        195                 200                 205             


Thr Thr Thr Gly Asn Gly Ala Asp Pro Ser Ile Thr Ala Ala Phe Val 
    210                 215                 220                 


Ser Gln Leu Gln Ala Leu Cys Pro Gln Asn Gly Asp Gly Ser Arg Arg 
225                 230                 235                 240 


Ile Gly Leu Asp Thr Gly Ser Val Asn Arg Phe Asp Asn Ser Phe Phe 
                245                 250                 255     


Ala Asn Leu Arg Asp Gly Lys Gly Ile Leu Glu Ser Asp Gln Arg Leu 
            260                 265                 270         


Trp Thr Asp Ala Ser Thr Lys Thr Phe Val Gln Arg Phe Leu Gly Ile 
        275                 280                 285             


Arg Gly Leu Leu Gly Leu Thr Phe Asn Ile Glu Phe Gly Arg Ser Met 
    290                 295                 300                 


Val Lys Met Ser Asn Ile Glu Val Lys Thr Gly Thr Val Gly Glu Ile 
305                 310                 315                 320 


Arg Lys Val Cys Ser Lys Val Asn 
                325             


<210>  186
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  186

Met Ala Met Ala Ser Leu Lys Ala Ser Ser Val Ala Thr Leu Leu Leu 
1               5                   10                  15      


Phe Ala Val Leu Ile Ser Leu Arg Gly Leu Glu Ala Gln Thr Pro Pro 
            20                  25                  30          


Val Ala Pro Gly Leu Ser Tyr Thr Phe Tyr Gln Thr Thr Cys Pro Gln 
        35                  40                  45              


Leu Gln Thr Ile Ile Arg Gln Gln Leu Gln Thr Val Phe Asn Ser Asp 
    50                  55                  60                  


Ile Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His Asp Cys Phe 
65                  70                  75                  80  


Val Gln Gly Cys Asp Gly Ser Val Leu Leu Asp Gly Ser Ala Ser Gly 
                85                  90                  95      


Pro Ser Glu Lys Ser Ala Ile Pro Asn Leu Thr Leu Arg Ala Gln Ala 
            100                 105                 110         


Phe Val Ile Ile Glu Asn Leu Arg Arg Leu Val His Asn Ala Cys Asn 
        115                 120                 125             


Arg Thr Val Ser Cys Ala Asp Ile Thr Ala Leu Ala Ala Arg Asp Ala 
    130                 135                 140                 


Val Val Leu Ser Gly Gly Pro Asn Tyr Asn Ile Pro Leu Gly Arg Arg 
145                 150                 155                 160 


Asp Gly Leu Asn Phe Ala Thr Thr Asn Val Thr Leu Ala Asn Leu Pro 
                165                 170                 175     


Pro Pro Phe Ala Asn Thr Thr Thr Leu Leu Asn Ser Leu Ala Leu Lys 
            180                 185                 190         


Gly Phe Asn Pro Thr Asp Val Val Ala Leu Ser Gly Gly His Thr Ile 
        195                 200                 205             


Gly Ile Ala His Cys Thr Ser Phe Glu Ser Arg Leu Phe Pro Ser Arg 
    210                 215                 220                 


Asp Pro Thr Met Asp Gln Thr Phe Phe Asn Asn Leu Arg Thr Thr Cys 
225                 230                 235                 240 


Pro Ala Leu Asn Thr Thr Asn Thr Thr Phe Met Asp Ile Arg Ser Pro 
                245                 250                 255     


Asn Val Phe Asp Asn Arg Tyr Tyr Val Asp Leu Met Asn Arg Gln Gly 
            260                 265                 270         


Leu Phe Thr Ser Asp Gln Asp Leu Tyr Thr Asp Ser Arg Thr Arg Gly 
        275                 280                 285             


Ile Val Thr Asn Phe Ala Ile Asn Gln Thr Leu Phe Phe Gln Asn Phe 
    290                 295                 300                 


Val Asn Ala Met Ile Lys Met Ser Gln Leu Ser Val Leu Thr Gly Thr 
305                 310                 315                 320 


Gln Gly Glu Ile Arg Ala Asn Cys Ser Arg Arg Asn Gly Asn Asp Leu 
                325                 330                 335     


Phe Ile Leu Pro Gly Met Glu Lys Asn Asp Asp Glu Lys Val Ala Ser 
            340                 345                 350         


Tyr 
    


<210>  187
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  187

Met Ala Ser Thr Leu Thr Ser Leu Ser Ser Leu Phe Phe Phe Phe Ser 
1               5                   10                  15      


Ser Leu Ser Leu Leu Leu Tyr His Leu His Val Ser Glu Ala Gln Thr 
            20                  25                  30          


Pro Pro Ile Val Lys Gly Leu Ser Leu Ala Phe Phe Asp Ser Thr Cys 
        35                  40                  45              


Pro Lys Leu Glu Ser Ile Val Arg Lys Gln Leu Glu Lys Glu Phe Lys 
    50                  55                  60                  


Ala Asp Ile Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His Asp 
65                  70                  75                  80  


Cys Phe Val Gln Gly Cys Asp Ala Ser Val Leu Leu Asp Gly Ser Ala 
                85                  90                  95      


Ser Gly Pro Ser Glu Lys Asn Ala Pro Pro Asn Leu Ser Leu Arg Ala 
            100                 105                 110         


Lys Ala Phe Thr Ile Ile Glu Asp Leu Arg Arg Gln Val His Lys Gln 
        115                 120                 125             


Cys Gly Lys Ile Val Ser Cys Ala Asp Ile Thr Ala Leu Ala Ala Arg 
    130                 135                 140                 


Asp Ala Val Val Leu Ser Gly Gly Pro Asn Tyr Gln Val Pro Tyr Gly 
145                 150                 155                 160 


Arg Arg Asp Gly Leu Gln Phe Ala Thr Arg Gln Ala Thr Leu Ala Asn 
                165                 170                 175     


Leu Pro Pro Pro Phe Ala Asn Thr Thr Thr Ile Leu Asn Ser Leu Val 
            180                 185                 190         


Thr Lys Asn Phe Asp Pro Thr Asp Val Val Ala Leu Ser Gly Ala His 
        195                 200                 205             


Thr Ile Gly Leu Ser His Cys Ser Ser Phe Ile Arg Arg Leu Phe Pro 
    210                 215                 220                 


Thr Gln Asp Ser Thr Met Ala Gln Ser Phe Ala Lys Asp Leu Arg Ile 
225                 230                 235                 240 


Thr Cys Pro Thr Asn Thr Thr Asp Asn Thr Thr Asn Leu Asp Phe Arg 
                245                 250                 255     


Thr Pro Asn Val Phe Asp Asn Lys Tyr Tyr Val Asp Leu Val Asn Arg 
            260                 265                 270         


Gln Gly Leu Phe Thr Ser Asp Gln Asp Leu Phe Thr Asp Asn Arg Thr 
        275                 280                 285             


Arg Gly Ile Val Thr Ser Phe Ala Asn Asn Gln Thr Leu Phe Phe Glu 
    290                 295                 300                 


Lys Phe Val Asn Ala Met Leu Lys Met Gly Gln Leu Ser Val Leu Thr 
305                 310                 315                 320 


Gly Thr Gln Gly Glu Ile Arg Gly Asn Cys Ser Val Lys Asn Ser Asn 
                325                 330                 335     


Asn Leu Phe Leu Ser Thr Val Val Glu Glu Gly Met Glu Asn Leu Leu 
            340                 345                 350         


Gly Phe 
        


<210>  188
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  188

Met Ser Leu Ser Thr Ile Ser Leu Arg Ser Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu His Val Ser Leu Asn Ala Ile Gln Ala Gln Thr Tyr Pro 
            20                  25                  30          


Pro Leu Val Asn Gly Leu Ser Trp Thr Phe His Asp Phe Asp Cys Pro 
        35                  40                  45              


Asn Leu Glu Ser Ile Ile Thr Asn Arg Leu Arg Gln Val Phe Gln Asn 
    50                  55                  60                  


Asp Ile Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His Asp Cys 
65                  70                  75                  80  


Phe Val Gln Gly Cys Asp Ala Ser Val Leu Leu Val Gly Ser Ala Ser 
                85                  90                  95      


Gly Pro Ser Glu Gln Ala Ala Pro Pro Asn Leu Ser Leu Arg Gln Gln 
            100                 105                 110         


Ala Phe Arg Ile Ile Glu Asp Leu Arg Asn Arg Val His Arg Gln Cys 
        115                 120                 125             


Gly Arg Val Val Ser Cys Ala Asp Ile Thr Ala Leu Ala Ala Arg Asp 
    130                 135                 140                 


Ala Ile Val Leu Ser Gly Gly Pro Ala Tyr Glu Val Pro Leu Gly Arg 
145                 150                 155                 160 


Arg Asp Gly Thr Thr Phe Ala Thr Arg Asn Glu Thr Leu Arg Asn Leu 
                165                 170                 175     


Pro Ala Pro Thr Ser Asn Thr Ser Val Leu Leu Thr Ser Leu Ala Thr 
            180                 185                 190         


Asn Gln Asn Leu Asn Ala Thr Asp Leu Val Ala Leu Ser Gly Gly His 
        195                 200                 205             


Thr Ile Gly Ile Gly His Cys Thr Ser Phe Glu Gly Arg Leu Phe Pro 
    210                 215                 220                 


Ala Arg Asp Pro Thr Met Asp Gln Thr Phe Phe Asn Asn Leu Arg Gly 
225                 230                 235                 240 


Thr Cys Pro Ala Leu Asn Thr Thr Asn Thr Thr Val Leu Asp Ile Arg 
                245                 250                 255     


Ser Pro Asn Val Phe Asp Asn Arg Tyr Tyr Val Asp Leu Met Asn Arg 
            260                 265                 270         


Gln Gly Leu Phe Thr Ser Asp Gln Asp Met Tyr Thr Asp Ser Arg Thr 
        275                 280                 285             


Arg Gly Ile Ile Thr Ser Phe Ala Val Asn Gln Thr Leu Phe Phe Glu 
    290                 295                 300                 


Lys Phe Val Tyr Ser Met Thr Lys Met Gly Gln Leu Asn Val Leu Thr 
305                 310                 315                 320 


Gly Thr Arg Gly Glu Ile Arg Ala Asn Cys Ser Val Arg Asn Ser Gly 
                325                 330                 335     


Asn Asp Phe Leu Ser Leu Val Val Glu Ser Gln Gly Gly Asp Leu Ser 
            340                 345                 350         


Gly Phe 
        


<210>  189
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  189

Met Val Phe Met Ser Ser Phe Ser Ser Ser Ser Ser Ser Thr Ser Leu 
1               5                   10                  15      


Leu Leu Phe Leu Ile Ser Ser Leu Leu Ile Ser Thr His Phe Asn Val 
            20                  25                  30          


His Ile Glu Ala Gln Thr Thr Pro Pro Ile Val Ser Gly Leu Ser Phe 
        35                  40                  45              


Thr Phe Tyr Asp Ser Ser Cys Pro Asp Leu Glu Ser Ile Ile Arg Asn 
    50                  55                  60                  


Arg Leu Arg Arg Val Phe Arg Asn Asp Ile Gly Gln Ala Ala Gly Leu 
65                  70                  75                  80  


Leu Arg Leu His Phe His Asp Cys Phe Val Gln Gly Cys Asp Gly Ser 
                85                  90                  95      


Val Leu Leu Val Gly Ser Ala Ser Gly Pro Gly Glu Gln Asp Ala Pro 
            100                 105                 110         


Pro Asn Leu Ser Leu Arg Gln Glu Ala Phe Arg Ile Ile Asn Asp Leu 
        115                 120                 125             


Arg Arg Arg Val His Ser Arg Cys Gly Arg Ile Val Ser Cys Ser Asp 
    130                 135                 140                 


Ile Leu Ala Leu Ala Ala Arg Asp Ser Val Val Leu Ser Gly Gly Pro 
145                 150                 155                 160 


Glu Tyr Asp Val Pro Leu Gly Arg Arg Asp Gly Leu Asn Phe Ala Thr 
                165                 170                 175     


Gln Asn Glu Thr Leu Asn Asn Leu Pro Pro Pro Ser Ser Asn Thr Ser 
            180                 185                 190         


Glu Leu Leu Thr Ser Leu Ala Thr Lys Asn Phe Asn Ala Thr Asp Val 
        195                 200                 205             


Val Ala Leu Ser Gly Gly His Thr Ile Gly Val Gly His Cys Val Ser 
    210                 215                 220                 


Phe Glu Glu Arg Leu Tyr Pro Thr Gln Asp Pro Thr Met Asp Gln Thr 
225                 230                 235                 240 


Phe Ala Arg Asn Leu Arg Leu Thr Cys Pro Ala Leu Asn Thr Thr Asn 
                245                 250                 255     


Thr Thr Val Leu Asp Ile Arg Ser Pro Asn Arg Phe Asp Asn Arg Tyr 
            260                 265                 270         


Tyr Val Asp Leu Met Asn Arg Gln Gly Leu Phe Thr Ser Asp Gln Asp 
        275                 280                 285             


Leu Tyr Thr Asp Arg Arg Thr Arg Gly Ile Val Thr Asp Phe Ala Val 
    290                 295                 300                 


Asn Gln Thr Leu Phe Phe Glu Lys Phe Val Tyr Ala Met Ile Lys Met 
305                 310                 315                 320 


Gly Gln Leu Asn Val Leu Thr Gly Asn Gln Gly Glu Ile Arg Ala Asn 
                325                 330                 335     


Cys Ser Val Arg Asn Ala Ala Ser Gly Arg Ser Ser Ser Leu Val Ser 
            340                 345                 350         


Val Val Glu Asp Ala Ala Glu Val Gly Leu Ser Met Phe 
        355                 360                 365 


<210>  190
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  190

Met Ala Ser Ile Thr Leu Ser Ser Phe Ala Ala Ser Leu Leu Leu Ile 
1               5                   10                  15      


Leu Ser Val Asn Phe Tyr Gln Thr Glu Ala Gln Gly Thr Gln Pro Ile 
            20                  25                  30          


Val Lys Gly Leu Ser Trp Thr Phe Tyr Asp Ser Ile Cys Pro Asn Ala 
        35                  40                  45              


Glu Ser Ile Ile Arg Ser Arg Leu Gln Gln Val Phe Arg Gln Asp Ile 
    50                  55                  60                  


Gly Gln Ala Ala Gly Leu Leu Arg Leu His Phe His Asp Cys Phe Val 
65                  70                  75                  80  


Gln Gly Cys Asp Gly Ser Val Leu Leu Asp Gly Ser Ala Ser Gly Pro 
                85                  90                  95      


Ser Glu Lys Asp Ala Pro Pro Asn Leu Thr Leu Arg Gln Gln Ala Phe 
            100                 105                 110         


Arg Ile Ile Glu Asp Leu Arg Arg Arg Val His Arg Asp Cys Gly Arg 
        115                 120                 125             


Val Val Ser Cys Ala Asp Ile Thr Ala Ile Ala Ala Arg Asp Ser Val 
    130                 135                 140                 


Phe Leu Ser Gly Gly Pro Asp Tyr Asp Leu Pro Leu Gly Arg Arg Asp 
145                 150                 155                 160 


Gly Leu Asn Phe Ala Thr Arg Asn Glu Thr Leu Ala Asn Leu Pro Pro 
                165                 170                 175     


Pro Ser Phe Asn Ala Ser Ala Ile Leu Thr Ser Leu Ala Thr Lys Asn 
            180                 185                 190         


Phe Thr Pro Thr Asp Val Val Ala Leu Ser Gly Gly His Thr Ile Gly 
        195                 200                 205             


Ile Gly His Cys Thr Ser Phe Thr Glu Arg Leu Tyr Pro Asn Gln Asp 
    210                 215                 220                 


Pro Ser Met Asp Lys Thr Phe Ala Asn Asn Leu Lys Asn Thr Cys Pro 
225                 230                 235                 240 


Thr Ser Asn Ser Thr Asn Thr Thr Val Leu Asp Ile Arg Ser Pro Asn 
                245                 250                 255     


Lys Phe Asp Asn Lys Tyr Tyr Val Asp Leu Met Asn Arg Gln Gly Leu 
            260                 265                 270         


Phe Thr Ser Asp Gln Asp Leu Tyr Thr Asp Arg Arg Thr Arg Gly Ile 
        275                 280                 285             


Val Thr Ser Phe Ala Ile Asn Glu Ser Leu Phe Phe Glu Glu Phe Val 
    290                 295                 300                 


Asn Ser Met Ile Lys Met Gly Gln Leu Asn Val Leu Thr Gly Thr Gln 
305                 310                 315                 320 


Gly Glu Ile Arg Ala Asn Cys Ser Val Arg Asn Ser Ala Asn Tyr Asn 
                325                 330                 335     


Leu Leu Leu Ser Thr Ser Val Ala Glu Glu Gln Gln Arg Thr Trp Ser 
            340                 345                 350         


Glu Ile 
        


<210>  191
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (189)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  191

Met Ala Ala Ala Ser Ser Arg Thr Arg Val Cys Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Ser Ala Ile Leu Val Val Ser His Leu Leu Val Thr Gln Ala Ala 
            20                  25                  30          


Ala Ser Asp Val Pro Ile Val Asn Gly Leu Ser Phe Ser Phe Tyr Asp 
        35                  40                  45              


Lys Ser Cys Pro Lys Leu Glu Ser Ile Val Arg Thr Glu Leu Lys Lys 
    50                  55                  60                  


Ile Phe Lys Lys Asp Ile Gly Gln Thr Ala Gly Leu Leu Arg Leu His 
65                  70                  75                  80  


Phe His Asp Cys Phe Val Gln Gly Cys Asp Gly Ser Val Leu Leu Asp 
                85                  90                  95      


Gly Ser Ala Ser Gly Pro Ser Glu Lys Asp Ala Pro Pro Asn Leu Ser 
            100                 105                 110         


Leu Arg Ala Gln Ala Phe Lys Ile Ile Asp Asp Leu Arg Ala Arg Val 
        115                 120                 125             


His Lys Arg Cys Gly Arg Ile Val Ser Cys Ala Asp Ile Thr Ala Leu 
    130                 135                 140                 


Ala Ala Arg Asp Ser Val Phe Leu Ser Gly Gly Pro Glu Tyr Asp Ile 
145                 150                 155                 160 


Pro Leu Gly Arg Arg Asp Gly Leu Thr Phe Ala Thr Arg Asn Val Thr 
                165                 170                 175     


Leu Ala Asn Leu Pro Ala Pro Ser Ser Thr Ala Ala Xaa Ile Leu Asp 
            180                 185                 190         


Ser Leu Ala Thr Lys Asn Leu Asn Pro Thr Asp Val Val Ala Leu Ser 
        195                 200                 205             


Gly Gly His Thr Ile Gly Ile Gly His Cys Ser Ser Phe Thr Asn Arg 
    210                 215                 220                 


Leu Phe Pro Gln Asp Pro Val Met Asp Lys Thr Phe Ala Lys Asn Leu 
225                 230                 235                 240 


Lys Leu Thr Cys Pro Thr Asn Thr Thr Asp Asn Thr Thr Val Leu Asp 
                245                 250                 255     


Ile Arg Ser Pro Asn Lys Phe Asp Asn Lys Tyr Tyr Val Asp Leu Met 
            260                 265                 270         


Asn Arg Gln Gly Leu Phe Thr Ser Asp Gln Asp Leu Tyr Thr Asp Lys 
        275                 280                 285             


Lys Thr Arg Gly Ile Val Thr Ser Phe Ala Val Asn Gln Ser Leu Phe 
    290                 295                 300                 


Phe Glu Lys Phe Val Asp Ala Met Leu Lys Met Gly Gln Leu Ser Val 
305                 310                 315                 320 


Leu Thr Gly Ser Gln Gly Glu Ile Arg Ala Asn Cys Ser Val Arg Asn 
                325                 330                 335     


Thr Asp Asn Lys Ser Ile Leu Thr Ser Ile Val Val Asp Val Val Glu 
            340                 345                 350         


Glu Ile Leu Glu Met 
        355         


<210>  192
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  192

Met Gly Ala Arg Ile Ile Phe Phe Phe Ala Leu Leu Ser Phe Ser Ala 
1               5                   10                  15      


Leu Ser Leu Arg Pro Ala Phe Gly Asp Asn Glu Glu Gly Asp Thr Gly 
            20                  25                  30          


Leu Ile Met Asn Phe Tyr Lys Asp Thr Cys Pro Gln Ala Glu Asp Ile 
        35                  40                  45              


Ile Lys Glu Gln Val Lys Leu Leu Tyr Lys Arg His Lys Asn Thr Ala 
    50                  55                  60                  


Phe Ser Trp Leu Arg Asn Ile Phe His Asp Cys Ala Val Gln Ser Cys 
65                  70                  75                  80  


Asp Ala Ser Leu Leu Leu Asp Ser Thr Arg Arg Val Leu Ser Glu Lys 
                85                  90                  95      


Glu Thr Asp Arg Ser Phe Gly Met Arg Asn Phe Arg Tyr Val Glu Thr 
            100                 105                 110         


Ile Lys Glu Ala Val Glu Arg Glu Cys Pro Gly Val Val Ser Cys Ala 
        115                 120                 125             


Asp Ile Leu Val Leu Ser Ala Arg Asp Gly Ile Val Ala Leu Gly Gly 
    130                 135                 140                 


Pro Phe Ile Pro Leu Lys Thr Gly Arg Arg Asp Gly Arg Lys Ser Arg 
145                 150                 155                 160 


Ala Asp Val Leu Glu Glu Tyr Leu Pro Asp His Asn Glu Ser Ile Ser 
                165                 170                 175     


Val Val Leu Asp Arg Phe Ala Ser Met Gly Ile Asp Thr Pro Gly Val 
            180                 185                 190         


Val Ala Leu Leu Gly Ala His Ser Val Gly Arg Thr His Cys Val Lys 
        195                 200                 205             


Leu Val His Arg Leu Tyr Pro Glu Val Asp Pro Val Leu Asn Pro Asp 
    210                 215                 220                 


His Val Glu His Met Leu His Lys Cys Pro Asp Ala Leu Pro Asp Pro 
225                 230                 235                 240 


Lys Ala Val Gln Tyr Val Arg Asn Asp Arg Gly Thr Pro Met Ile Leu 
                245                 250                 255     


Asp Asn Asn Tyr Tyr Arg Asn Ile Leu Asp Asn Lys Gly Leu Leu Ile 
            260                 265                 270         


Val Asp His Gln Leu Ala Thr Asp Lys Arg Thr Lys Pro Tyr Val Lys 
        275                 280                 285             


Lys Met Ala Lys Ser Gln Gly Tyr Phe Phe Lys Glu Phe Ser Arg Ala 
    290                 295                 300                 


Ile Thr Ile Leu Ser Glu Asn Asn Pro Leu Thr Gly Asn Lys Gly Glu 
305                 310                 315                 320 


Ile Arg Lys Gln Cys Asn Val Ala Asn Lys Leu His 
                325                 330         


<210>  193
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  193

Met Arg Lys Ile Met Gly Ala Lys Val Leu Phe Phe Phe Ala Leu Leu 
1               5                   10                  15      


Ser Phe Ser Ala Val Ser Ala Phe Ala Gln Asp Glu Glu Asp Gln Gly 
            20                  25                  30          


Leu Val Met Asn Phe Tyr Lys Asp Ser Cys Pro Gln Ala Glu Asp Ile 
        35                  40                  45              


Ile Lys Glu Gln Val Lys Leu Leu Tyr Lys Arg His Lys Asn Thr Ala 
    50                  55                  60                  


Phe Ser Trp Leu Arg Asn Ile Phe His Asp Cys Ala Val Gln Ser Cys 
65                  70                  75                  80  


Asp Ala Ser Leu Leu Leu Asp Ser Thr Arg Arg Ser Leu Ser Glu Lys 
                85                  90                  95      


Glu Thr Asp Arg Ser Phe Gly Leu Arg Asn Phe Arg Tyr Ile Glu Thr 
            100                 105                 110         


Ile Lys Glu Ala Val Glu Arg Glu Cys Pro Gly Val Val Ser Cys Ala 
        115                 120                 125             


Asp Ile Leu Val Leu Ser Ala Arg Glu Gly Ile Val Ser Leu Gly Gly 
    130                 135                 140                 


Pro Tyr Ile Pro Leu Lys Thr Gly Arg Arg Asp Gly Arg Arg Ser Arg 
145                 150                 155                 160 


Ala Asp Val Val Glu Glu Tyr Leu Pro Asp His Asn Glu Thr Ile Ser 
                165                 170                 175     


Gly Val Leu Asp Arg Phe Ala Ala Met Gly Ile Asp Thr Pro Gly Val 
            180                 185                 190         


Val Ala Leu Leu Gly Ala His Ser Val Gly Arg Thr His Cys Val Lys 
        195                 200                 205             


Leu Val His Arg Leu Tyr Pro Glu Val Asp Pro Ala Leu Ser Pro Asp 
    210                 215                 220                 


His Val Pro His Met Leu His Lys Cys Pro Asp Gln Ile Pro Asp Pro 
225                 230                 235                 240 


Lys Ala Val Gln Tyr Val Arg Asn Asp Arg Gly Thr Pro Met Val Leu 
                245                 250                 255     


Asp Asn Asn Tyr Tyr Arg Asn Ile Leu Asp Asn Lys Gly Leu Leu Ile 
            260                 265                 270         


Val Asp His Gln Leu Ala Tyr Asp Lys Arg Thr Arg Pro Tyr Val Lys 
        275                 280                 285             


Lys Met Ala Lys Ser Gln Asp Tyr Phe Phe Lys Glu Phe Ser Arg Ala 
    290                 295                 300                 


Ile Thr Leu Leu Ser Glu Asn Asn Pro Leu Thr Gly Ser Lys Gly Glu 
305                 310                 315                 320 


Ile Arg Lys Gln Cys Asn Leu Ala Asn Lys Leu His 
                325                 330         


<210>  194
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  194

Met Asp Ser Lys Ala Leu Phe Phe Phe Ala Leu Val Cys Phe Cys Ala 
1               5                   10                  15      


Val Ala Leu Arg Pro Val Phe Ala Glu Asn Glu Glu Asp Pro Gly Leu 
            20                  25                  30          


Val Met Thr Phe Tyr Lys Asp Ser Cys Pro Gln Ala Glu Asp Ile Ile 
        35                  40                  45              


Lys Glu Gln Val Lys Leu Leu Tyr Lys Arg His Lys Asn Thr Ala Phe 
    50                  55                  60                  


Ser Trp Leu Arg Asn Ile Phe His Asp Cys Ala Val Gln Ser Cys Asp 
65                  70                  75                  80  


Ala Ser Leu Leu Leu Asp Ser Thr Arg Arg Asp Leu Ser Glu Lys Glu 
                85                  90                  95      


Thr Asp Arg Ser Phe Gly Leu Arg Asn Phe Arg Tyr Leu Asp Thr Ile 
            100                 105                 110         


Lys Glu Ala Val Glu Arg Glu Cys Pro Gly Val Val Ser Cys Ala Asp 
        115                 120                 125             


Ile Leu Val Leu Ser Ala Arg Asp Gly Ile Val Ala Leu Gly Gly Pro 
    130                 135                 140                 


Tyr Ile Pro Leu Lys Thr Gly Arg Arg Asp Gly Arg Arg Ser Arg Ala 
145                 150                 155                 160 


Asp Val Ile Glu Gln Phe Leu Pro Asp His Asn Glu Ser Ile Ser Val 
                165                 170                 175     


Val Leu Asp Arg Phe Ala Ala Met Gly Ile Asp Thr Pro Gly Val Val 
            180                 185                 190         


Ala Leu Leu Gly Ala His Ser Val Gly Arg Thr His Cys Val Lys Leu 
        195                 200                 205             


Val His Arg Leu Tyr Pro Glu Val Asp Pro Ala Leu Asn Pro Asp His 
    210                 215                 220                 


Val Glu His Met Phe Lys Lys Cys Pro Asp Pro Ile Pro Asp Pro Lys 
225                 230                 235                 240 


Ala Val Gln Tyr Val Arg Asn Asp Arg Gly Thr Pro Met Lys Leu Asp 
                245                 250                 255     


Asn Asn Tyr Tyr Arg Asn Ile Met Asp Asn Lys Gly Leu Leu Ile Val 
            260                 265                 270         


Asp His Gln Leu Ala Asn Asp Lys Arg Thr Lys Pro Tyr Val Lys Lys 
        275                 280                 285             


Met Ala Lys Ser Gln Asp Tyr Phe Phe Lys Glu Phe Ala Arg Ala Ile 
    290                 295                 300                 


Thr Ile Leu Ser Glu Asn Asn Pro Leu Thr Gly Thr Lys Gly Glu Ile 
305                 310                 315                 320 


Arg Lys Gln Cys Ser Val Ala Asn Lys His His 
                325                 330     


<210>  195
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  195

Met Gly Ser Lys Val Leu Phe Phe Phe Ala Ile Leu Ser Leu Ser Val 
1               5                   10                  15      


Leu Phe Ser Leu Asn Leu Asn Leu Ala Phe Ala Glu Asn Glu Glu Ile 
            20                  25                  30          


Glu Glu Gln Val Gly Leu Val Met Asn Phe Tyr Lys Asp Thr Cys Pro 
        35                  40                  45              


Gln Ala Glu Glu Val Ile Arg Glu Gln Val Lys Leu Leu Tyr Lys Arg 
    50                  55                  60                  


His Lys Asn Thr Ala Phe Ser Trp Leu Arg Asn Ile Phe His Asp Cys 
65                  70                  75                  80  


Ala Val Thr Ser Cys Asp Ala Ser Leu Leu Leu Asp Ser Thr Arg Arg 
                85                  90                  95      


Ser Leu Ser Glu Lys Glu Thr Asp Arg Ser Phe Gly Leu Arg Asn Phe 
            100                 105                 110         


Arg Tyr Leu Asp Thr Ile Lys Glu Ala Val Glu Arg Glu Cys Pro Gly 
        115                 120                 125             


Val Val Ser Cys Ser Asp Ile Leu Val Leu Ser Ala Arg Asp Gly Ile 
    130                 135                 140                 


Val Ala Leu Gly Gly Pro Tyr Ile Pro Leu Lys Thr Gly Arg Arg Asp 
145                 150                 155                 160 


Gly Arg Lys Ser Arg Ala Glu Val Leu Glu Gln Tyr Leu Pro Asp His 
                165                 170                 175     


Asn Glu Ser Met Ser Val Val Leu Glu Arg Phe Ala Ser Ile Gly Ile 
            180                 185                 190         


Asp Thr Pro Gly Val Val Ala Leu Leu Gly Ala His Ser Val Gly Arg 
        195                 200                 205             


Thr His Cys Val Lys Leu Val His Arg Leu Tyr Pro Glu Val Asp Pro 
    210                 215                 220                 


Val Leu Asn Pro Asp His Val Glu His Met Leu His Lys Cys Pro Asp 
225                 230                 235                 240 


Pro Ile Pro Asp Pro Lys Ala Val Gln Tyr Val Arg Asn Asp Arg Gly 
                245                 250                 255     


Thr Pro Met Lys Leu Asp Asn Asn Tyr Tyr Arg Asn Ile Leu Asp Asn 
            260                 265                 270         


Lys Gly Leu Leu Ile Val Asp His Gln Leu Ala Thr Asp Lys Arg Thr 
        275                 280                 285             


Lys Pro Phe Val Lys Lys Met Ala Lys Ser Gln Asp Tyr Phe Phe Lys 
    290                 295                 300                 


Glu Phe Ala Arg Ala Ile Thr Ile Leu Ser Glu Asn Asn Pro Leu Thr 
305                 310                 315                 320 


Gly Thr Lys Gly Glu Ile Arg Lys Gln Cys Asn Val Ala Asn Lys Leu 
                325                 330                 335     


His 
    


<210>  196
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  196

Met Ala Ser Lys Thr Leu Phe Phe Leu Val Ile Leu Ser Phe Ser Ala 
1               5                   10                  15      


Leu Ser Thr Phe Ala Glu Asn Glu Ala Glu Ala Asp Pro Gly Leu Val 
            20                  25                  30          


Met Asn Tyr Tyr Lys Asp Ser Cys Pro Gln Ala Glu Asp Ile Ile Arg 
        35                  40                  45              


Glu Gln Val Lys Leu Leu Tyr Lys Arg His Lys Asn Thr Ala Phe Ser 
    50                  55                  60                  


Trp Leu Arg Asn Ile Phe His Asp Cys Phe Val Glu Ser Cys Asp Ala 
65                  70                  75                  80  


Ser Leu Leu Leu Asp Ser Thr Arg Arg Val Leu Ser Glu Lys Glu Thr 
                85                  90                  95      


Asp Arg Ser Phe Gly Met Arg Asn Phe Arg Tyr Leu Glu Asp Ile Lys 
            100                 105                 110         


Glu Ala Leu Glu Arg Glu Cys Pro Gly Val Val Ser Cys Ala Asp Ile 
        115                 120                 125             


Leu Val Leu Ser Ala Arg Asp Gly Ile Val Ser Leu Gly Gly Pro Phe 
    130                 135                 140                 


Ile Pro Leu Lys Thr Gly Arg Arg Asp Gly Arg Arg Ser Arg Ala Glu 
145                 150                 155                 160 


Ile Leu Glu Gln His Leu Pro Asp His Asn Glu Ser Leu Thr Val Val 
                165                 170                 175     


Leu Glu Arg Phe Gly Ser Ile Gly Ile Asn Thr Pro Gly Leu Val Ala 
            180                 185                 190         


Leu Leu Gly Ala His Ser Val Gly Arg Thr His Cys Val Lys Leu Val 
        195                 200                 205             


His Arg Leu Tyr Pro Glu Val Asp Pro Ala Phe Pro Glu Ser His Val 
    210                 215                 220                 


Gln His Met Leu Lys Lys Cys Pro Asp Pro Ile Pro Asp Pro Lys Ala 
225                 230                 235                 240 


Val Gln Tyr Val Arg Asn Asp Arg Gly Thr Pro Met Lys Leu Asp Asn 
                245                 250                 255     


Asn Tyr Tyr Arg Asn Ile Leu Asp Asn Lys Gly Leu Leu Leu Val Asp 
            260                 265                 270         


His Gln Leu Ala Thr Asp Lys Arg Thr Lys Pro Phe Val Lys Lys Met 
        275                 280                 285             


Ala Lys Ser Gln Asp Tyr Phe Phe Lys Glu Phe Ala Arg Ala Ile Thr 
    290                 295                 300                 


Ile Leu Ser Glu Asn Asn Pro Leu Thr Gly Thr Lys Gly Glu Ile Arg 
305                 310                 315                 320 


Lys Gln Cys Asn Val Ala Asn Lys Leu His 
                325                 330 


<210>  197
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  197

Met Gly Phe Lys Val Phe Phe Phe Phe Ala Ile Leu Phe Phe Ser Ala 
1               5                   10                  15      


Val Ser Ala Phe Ala Glu Asp Asn Ser Gly Leu Val Met Asp Tyr Tyr 
            20                  25                  30          


Lys Asp Ser Cys Pro Gln Ala Glu Asp Ile Ile Arg Glu Gln Val Lys 
        35                  40                  45              


Leu Leu Tyr Lys Arg His Lys Asn Thr Ala Phe Ser Trp Leu Arg Asn 
    50                  55                  60                  


Ile Phe His Asp Cys Phe Val Glu Ser Cys Asp Ala Ser Leu Leu Leu 
65                  70                  75                  80  


Asp Ser Thr Arg Arg Met Leu Ser Glu Lys Glu Thr Asp Arg Ser Phe 
                85                  90                  95      


Gly Met Arg Asn Phe Arg Tyr Ile Glu Thr Ile Lys Glu Ala Val Glu 
            100                 105                 110         


Arg Glu Cys Pro Gly Val Val Ser Cys Ala Asp Ile Leu Val Leu Ser 
        115                 120                 125             


Gly Arg Asp Gly Ile Val Ala Leu Gly Gly Pro Tyr Val Pro Leu Lys 
    130                 135                 140                 


Thr Gly Arg Arg Asp Gly Arg Lys Ser Arg Ala Asp Ile Leu Glu Gln 
145                 150                 155                 160 


His Leu Pro Asp His Asn Glu Ser Met Ser Val Val Leu Glu Arg Phe 
                165                 170                 175     


Ala Asn Val Gly Ile Asn Ala Pro Gly Val Val Ala Leu Leu Gly Ala 
            180                 185                 190         


His Ser Val Gly Arg Thr His Cys Val Lys Leu Val His Arg Leu Tyr 
        195                 200                 205             


Pro Glu Val Asp Pro Gln Leu Asn Pro Asp His Val Pro His Met Leu 
    210                 215                 220                 


Lys Lys Cys Pro Asp Pro Ile Pro Asp Pro Lys Ala Val Gln Tyr Val 
225                 230                 235                 240 


Arg Asn Asp Arg Gly Thr Pro Met Lys Leu Asp Asn Asn Tyr Tyr Arg 
                245                 250                 255     


Asn Ile Leu Glu Asn Lys Gly Leu Met Leu Val Asp His Gln Leu Ala 
            260                 265                 270         


Thr Asp Lys Arg Thr Lys Pro Tyr Val Lys Lys Met Ala Lys Ser Gln 
        275                 280                 285             


Asp Tyr Phe Phe Lys Glu Phe Ala Arg Ala Ile Thr Ile Leu Thr Glu 
    290                 295                 300                 


Asn Asn Pro Leu Thr Gly Thr Lys Gly Glu Ile Arg Lys Gln Cys Asn 
305                 310                 315                 320 


Leu Ala Asn Lys Leu His 
                325     


<210>  198
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  198

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val 
1               5                   10                  15      


Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
            20                  25                  30          


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
        35                  40                  45              


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
    50                  55                  60                  


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
65                  70                  75                  80  


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
                85                  90                  95      


Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe 
            100                 105                 110         


Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
        115                 120                 125             


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
    130                 135                 140                 


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
145                 150                 155                 160 


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
                165                 170                 175     


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
            180                 185                 190         


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
        195                 200                 205             


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
    210                 215                 220                 


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
225                 230                 235                 240 


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
                245                 250                 255     


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
            260                 265                 270         


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu 
        275                 280                 285             


Val Val Ile Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys 
    290                 295                 300                 


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
305                 310                 315                 320 


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
                325                 330                 335     


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
            340                 345                 350         


Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
        355                 360                 365             


Gly Arg Asp 
    370     


<210>  199
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  199

Met Ala Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala 
1               5                   10                  15      


Lys Leu Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly 
            20                  25                  30          


Asp Ile Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly 
        35                  40                  45              


Tyr Leu Pro Arg Asn Gly Val Ala Thr Pro Val Gln Ile Ile Asn Ala 
    50                  55                  60                  


Val Gln Glu Gly Leu Asn Phe Asp Asn Gln Ala Ala Val Phe Ala Thr 
65                  70                  75                  80  


Tyr Ala Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser 
                85                  90                  95      


Ile Gly Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala 
            100                 105                 110         


Ser Val Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser 
        115                 120                 125             


Met Thr Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu 
    130                 135                 140                 


Thr Leu Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly 
145                 150                 155                 160 


Lys Tyr Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln 
                165                 170                 175     


Asp Ser Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe 
            180                 185                 190         


Phe Thr Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp 
        195                 200                 205             


Gly Arg Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe 
    210                 215                 220                 


Phe Gln Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro 
225                 230                 235                 240 


Arg Ser Gly Thr Gly Val Glu Val Val Ile Gln Ala His Pro Met Gln 
                245                 250                 255     


Pro Gly Arg Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr 
            260                 265                 270         


Ser Ser Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn 
        275                 280                 285             


Ile Thr Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys 
    290                 295                 300                 


Ala Leu Asn Thr Asn Leu Asp Phe Phe Phe Gln Gly Val Ala Ala Gly 
305                 310                 315                 320 


Cys Thr Gln Val Phe Pro Tyr Gly Arg Asp 
                325                 330 


<210>  200
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  200

Met Ala Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala 
1               5                   10                  15      


Lys Leu Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly 
            20                  25                  30          


Asp Ile Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly 
        35                  40                  45              


Tyr Leu Pro Arg Asn Gly Val Ala Thr Pro Ala Gln Ile Ile Asn Ala 
    50                  55                  60                  


Val Gln Glu Gly Phe Asn Phe Asp Asn Gln Ala Ala Ile Phe Ala Thr 
65                  70                  75                  80  


Tyr Ala Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser 
                85                  90                  95      


Ile Gly Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala 
            100                 105                 110         


Ser Val Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser 
        115                 120                 125             


Met Thr Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu 
    130                 135                 140                 


Thr Leu Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly 
145                 150                 155                 160 


Lys Tyr Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln 
                165                 170                 175     


Asp Ser Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe 
            180                 185                 190         


Phe Thr Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp 
        195                 200                 205             


Gly Arg Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe 
    210                 215                 220                 


Phe Gln Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro 
225                 230                 235                 240 


Arg Ser Gly Thr Gly Val Glu Val Val Val Gln Ala His Pro Met Gln 
                245                 250                 255     


Pro Gly Arg Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr 
            260                 265                 270         


Ser Ser Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn 
        275                 280                 285             


Ile Thr Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys 
    290                 295                 300                 


Ala Leu Asn Thr Asn Leu Asp Phe Leu Phe Gln Gly Val Ala Ala Gly 
305                 310                 315                 320 


Cys Thr Gln Val Phe Pro Tyr Gly Arg Asp 
                325                 330 


<210>  201
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  201

Met Asn Lys Lys Lys Lys Thr Thr Ile Phe Leu Val Val Val Leu Leu 
1               5                   10                  15      


Phe Thr Ser Phe Pro Cys Phe Ser Thr Ala Thr Gln Ser Arg Lys Glu 
            20                  25                  30          


Leu Arg Val Lys Glu Val Val Asn Ala Ile Gln Leu Ser Arg Val Val 
        35                  40                  45              


Pro Pro Asn Thr Ile Asp Pro Ser Arg Val Thr His Leu Ser Trp Arg 
    50                  55                  60                  


Pro Arg Val Phe Leu Tyr Asn Arg Phe Leu Ser Asp Glu Glu Cys Gln 
65                  70                  75                  80  


His Leu Ile Ser Leu Ala Asn Asp Asp Asn Lys Ser Ser Gly Asn Ser 
                85                  90                  95      


Ser Ala Lys Val Met Glu Gly Ala Thr Asn Leu Asp Ile Ser Leu Glu 
            100                 105                 110         


Ile Lys Asp Glu Ile Thr Ser Lys Ile Glu Glu Arg Ile Ser Ala Trp 
        115                 120                 125             


Thr Phe Leu Pro Lys Gly Asn Gly Lys Pro Phe His Ile His His His 
    130                 135                 140                 


Val Gly Pro Glu Glu Ala Lys Glu Asn His Asn Tyr Leu Gly Asn Thr 
145                 150                 155                 160 


Ser Thr Gln Gln Gln Asn Gly Glu Ser Val Met Ala Thr Val Val Met 
                165                 170                 175     


Tyr Leu Ser Asn Val Thr Gln Gly Gly Gln Ile Ile Phe Pro Lys Ala 
            180                 185                 190         


Glu Ser Gly Ser Ser Arg Pro Lys Asp Lys Val Trp Ser Asp Cys Thr 
        195                 200                 205             


Met Asn Ser Pro Ile Thr Lys Pro Ile Lys Gly Asn Ala Leu Leu Phe 
    210                 215                 220                 


Phe Asn Leu His Pro Asn Thr Ser Leu Asp Pro Met Ser Leu His Ala 
225                 230                 235                 240 


Arg Cys Pro Ile Thr Glu Gly Asp Met Trp Trp Thr Thr Lys Ile Phe 
                245                 250                 255     


Met Val Lys Pro Ile Asn Gln Pro Lys Ser Val Ala Leu Lys Thr Ser 
            260                 265                 270         


Ser Asp Asp Leu Cys Thr Asp Glu Asp Asp Asn Cys Gln Gln Trp Ala 
        275                 280                 285             


Ala Phe Gly Glu Cys Glu Arg Asn Pro Ile Phe Met Val Gly Thr Ala 
    290                 295                 300                 


Asp Tyr Tyr Gly Thr Cys Arg Arg Ser Cys Asn Val Cys 
305                 310                 315         


<210>  202
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  202

Met Pro His Gln Ile Lys Glu Ser Gln Pro Lys Ala Asn Lys Asp Trp 
1               5                   10                  15      


Ser Glu Cys Ala Lys Lys Gly Tyr Ala Val Lys Pro Lys Lys Gly Asp 
            20                  25                  30          


Gly Leu Leu Phe Phe Ser Leu His Pro Asn Ala Thr Thr Asp Val Leu 
        35                  40                  45              


Ser Leu His Gly Ser Cys Pro Val Ile Glu Gly Glu Lys Trp Ser Val 
    50                  55                  60                  


Ile Asn Glu Pro Asn Gly Phe Ile Ser Gly Thr Leu Thr Asn Gln Ile 
65                  70                  75                  80  


Thr Gln Val Thr Asn Ala Met Met Lys Met Leu Thr Ala Arg His Gly 
                85                  90                  95      


Leu Pro Val Val Asn Ala 
            100         


<210>  203
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  203

Met Met Val Ala Ile Ala Tyr Phe Asn Tyr Ile Lys Tyr His Val Val 
1               5                   10                  15      


Val Leu Asp Leu Pro Gly His Arg Asp Phe Val Gln Asn Leu Ile Ser 
            20                  25                  30          


Gly Ala Thr Gln Ala Asp Ala Ser Ile Leu Val Ile Asp Ala Ser Ile 
        35                  40                  45              


Gly Ala Phe Glu Thr Asp Ile Glu Ile Gly Gly Gly Gln Thr Arg Glu 
    50                  55                  60                  


His Ala Gln Leu Ile Arg Ser Phe Met Leu Tyr Tyr Tyr His Leu Val 
65                  70                  75                  80  


Cys Asn Ser Trp Lys Gly Tyr Asp Ile Ser Phe Leu Ile Thr Ser Tyr 
                85                  90                  95      


Leu Leu Val Cys Asn Ser Trp Asn Tyr Val Gly Ser Phe Leu Ile Asn 
            100                 105                 110         


Ser Tyr Ile Thr Asn Tyr Tyr Gln Arg Gly Glu His Phe Leu Tyr Glu 
        115                 120                 125             


Lys Lys Asp Phe Leu Met Leu Glu Leu Ser Arg Val Val Pro Pro Asn 
    130                 135                 140                 


Thr Ile Asp Pro Ser Arg Val Pro Gln Leu Ser Trp Lys Pro Arg Ser 
145                 150                 155                 160 


Gly Glu Asn Glu Phe Val Val Phe Thr Glu Cys Asn Gly Ala Tyr Ser 
                165                 170                 175     


Val Phe Ser Glu Cys Tyr Ser Asp Ser Asp Asp Thr Pro Glu Tyr Leu 
            180                 185                 190         


Ser Ala Ser Thr Cys Lys Gly Gly Phe Gly Ile Val Phe Lys Trp Ser 
        195                 200                 205             


Leu Thr Asp Gly Met Val Val Ala Gly Lys Arg Leu Lys Asp Asp Asn 
    210                 215                 220                 


Ser Phe Gly Gly Asp Ile Gln Phe Gln Thr Glu Val Glu Thr Ile Ser 
225                 230                 235                 240 


Leu Val Val His Arg Asn Leu Leu Val Arg Phe Ser Phe Lys Leu His 
                245                 250                 255     


Ser Thr Phe Tyr Leu Val Lys Cys Ala Ser Ile Cys Val Pro Gly Thr 
            260                 265                 270         


Glu Leu Ser Asp Phe Thr Pro Val Ile Leu Gln Ser Thr Gln Ser Gln 
        275                 280                 285             


Ala Val Ile Ser Asn Gly Phe 
    290                 295 


<210>  204
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  204

Met Pro Phe Phe Asp Phe Phe Asp Ser Asn Arg Gly Gly Val Met Lys 
1               5                   10                  15      


Ala Phe Pro Asn Gln Tyr Arg Phe Phe Val Gln Val Gly Leu Gly Trp 
            20                  25                  30          


Val Trp Pro Val Gly Asn Lys Ser Ile Gln Val Phe Cys Thr Asp Asn 
        35                  40                  45              


Gly Ala Ser Asp Leu Pro Gly Gln Val Trp Gly Val Tyr Phe Gly Trp 
    50                  55                  60                  


Val Glu Gly His Ser Gln Glu Arg Leu Gln Ile Val Val Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Asp Gly Thr Ile Val Val Ala Leu Ser Gly Glu Thr Phe Thr 
                85                  90                  95      


Cys Trp Leu Asn Gln Gly Ile Leu Tyr Gln Ala Asn Phe Phe Asp Arg 
            100                 105                 110         


Cys Ser Asn Thr Gln Thr Lys Ile Lys Ser Val Ala Glu Ala Cys Leu 
        115                 120                 125             


Asn Leu Pro Ala Tyr Ser Tyr His Gln Leu Ser Tyr Leu Asn Leu Ser 
    130                 135                 140                 


Asn Ala Tyr Phe Ser Gly Val Ile Pro Pro His Ile Gly Asn Leu Ser 
145                 150                 155                 160 


Asn Leu Lys Val Leu Asp Leu Arg Ser Ser Thr Tyr Ser Tyr Asn Arg 
                165                 170                 175     


Leu Val Ser Asp Asp Met Ser Trp Met Ser Gly Leu Ser Ser Leu Glu 
            180                 185                 190         


Tyr Leu Asp Leu Ser Lys Ile Asp Leu Ser Lys Ala Gln Asn Arg Asp 
        195                 200                 205             


Met Val Phe Tyr Leu Met Pro Ser Leu Val Lys Leu Ser Leu Ser Gly 
    210                 215                 220                 


Cys Ser Leu Thr Asn Ala Asp Leu Gly Thr Leu Ser Tyr Ser Ser Thr 
225                 230                 235                 240 


Thr Leu Ala Asn Ile Lys His Leu Asp Leu Gly Tyr Asn His Phe Lys 
                245                 250                 255     


Gly Gln Phe Pro Gly Leu Phe Gln Asn Met Thr Ser Leu Glu Phe Leu 
            260                 265                 270         


Asp Leu Ser Tyr Phe Asn Phe Ser Leu Ser Leu Asn Ser Thr Asn Phe 
        275                 280                 285             


Leu Ser Thr Ile His Tyr Phe Pro Lys Met Arg Leu Ser Ser Cys Gly 
    290                 295                 300                 


Leu His Asn Met His Leu Ser Pro Asn His Leu Asn Phe Thr Thr Ile 
305                 310                 315                 320 


Ser Ile Ile Gln His Leu Asp Leu Ser Gln Asn Leu Leu Glu Gly Gly 
                325                 330                 335     


Phe Pro Ser Ala Leu Thr Asn Met Ser Ser Leu Leu Tyr Leu Asp Leu 
            340                 345                 350         


Ala Ser Asn Met Leu Asn Ser Ser Val Pro Ile Met Pro Asn Leu Leu 
        355                 360                 365             


Arg Phe Asp Leu Ser Arg Asn Asn Phe Glu His Ile Glu Asp Val Gly 
    370                 375                 380                 


Ile Trp Arg Gln Cys His Leu Lys Glu Leu Thr Val Ser Asp Asn Tyr 
385                 390                 395                 400 


Phe Lys Cys Ser Gln Tyr Ala Phe Lys Arg Leu His Leu Asp Gly Ser 
                405                 410                 415     


Leu Lys Gly Ala Phe Pro Ala Asp Thr Leu Gly Arg Met Val Asn Leu 
            420                 425                 430         


Arg Val Leu Arg Leu Ser Asp Asn Glu Leu Thr Gly Gln Ile Pro Glu 
        435                 440                 445             


Ser Leu Gly Arg Leu Arg Leu Leu Glu Glu Leu Asp Leu Ser His Asn 
    450                 455                 460                 


Gln Leu Arg Ser His Ser Asp Ile His Trp Lys Leu Val Ser Leu Gln 
465                 470                 475                 480 


Met Phe Ser Val Asp Leu Asn Ser Leu Asn Gly Thr Val Pro Val Ser 
                485                 490                 495     


Ile Gly Gln Leu Ala Lys Leu Lys Tyr Leu Asp Ile Ser Glu Asn Ser 
            500                 505                 510         


Leu Glu Gly Val Ile Thr Glu Ala His Phe Ala Asn Leu Ser Met Leu 
        515                 520                 525             


Lys Tyr Leu Phe Thr Ser Phe Asn Ser Val Ser Leu Glu Tyr Thr Thr 
    530                 535                 540                 


Thr Phe Gln Tyr Val Ile Asn Met Asp Leu Ser Ser Asn Asn Leu Val 
545                 550                 555                 560 


Gly Glu Ile Pro Val Glu Leu Met Ser Leu Ser Ala Leu Leu Gly Leu 
                565                 570                 575     


Asn Leu Ser Asn Asn His Leu Asn Gly Ser Ile Ser Tyr Ser Ile Gly 
            580                 585                 590         


Asn Met Lys Ala Leu Thr Ser Leu Asp Phe Ser Arg Asn Gln Leu Thr 
        595                 600                 605             


Ser Pro Ile Pro Pro Ser Ile Ala Thr Phe Asn Phe 
    610                 615                 620 


<210>  205
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  205

Met Lys Phe Thr Arg Arg Pro Ser Ala Pro Ala Thr Ser Ser Gln Asp 
1               5                   10                  15      


Ala His Leu Leu Val Arg Glu Thr Leu Arg Ile Ser Ala Asn Leu Ala 
            20                  25                  30          


Ser Ser Ser Ala Ala Pro Pro Ser Glu Asp Val Ile Arg Ser Ser Glu 
        35                  40                  45              


Ile Lys Arg Leu Glu Asp Gln Phe Val Asp Ala Ser Leu Arg Leu Ile 
    50                  55                  60                  


Cys Tyr Glu Glu Val Asp Gly Arg Arg Phe Lys Tyr Leu Arg Asn Ala 
65                  70                  75                  80  


Ser Ser Ser Asn Ser Asn Ser Asn Ser Ile Arg Ala Val Ser Leu Gln 
                85                  90                  95      


Ser Arg Gln Ala Pro Leu Asp Glu Leu Val Ser Phe Ile Arg Ser Tyr 
            100                 105                 110         


Val Val Pro Glu Gly Phe Pro Asp Ser Val Ser Pro Ser Tyr Val Pro 
        115                 120                 125             


Tyr Met Thr Trp Arg Ala Leu Lys His Phe Phe Gly Gly Ala Met Gly 
    130                 135                 140                 


Val Phe Thr Thr Gln Ala Leu Leu His Ser Val Gly Val Ser Lys Ser 
145                 150                 155                 160 


Gln Ala Met Pro Gly Ala Val Ala Ile Asn Trp Ile Ile Lys Asp Gly 
                165                 170                 175     


Ser Gly Arg Ile Gly Lys Met Leu Phe Ser Arg Gln Gly Lys Lys Phe 
            180                 185                 190         


Asp Tyr Asp Leu Lys Gln Leu Arg Leu Ser Gly Asp Leu Leu Met Glu 
        195                 200                 205             


Leu Gly Ala Gly Val Glu Leu Ala Thr Ala Ala Ala Pro His Leu Phe 
    210                 215                 220                 


Leu Pro Leu Ala Cys Ala Ala Asn Val Ala Lys Asn Val Ala Ala Val 
225                 230                 235                 240 


Thr Ser Thr Ser Thr Arg Thr Pro Ile Tyr Lys Ala Phe Ala Lys Gly 
                245                 250                 255     


Glu Asn Ile Gly Asp Val Thr Ala Lys Gly Glu Cys Val Gly Asn Val 
            260                 265                 270         


Ala Asp Leu Leu Gly Thr Gly Leu Ser Ile Ile Ile Ala Lys Arg Asn 
        275                 280                 285             


Pro Ser Leu Phe Thr Thr Phe Ala Leu Leu Ser Cys Gly Tyr Leu Phe 
    290                 295                 300                 


Ser Ser Tyr Arg Glu Val Lys Ser Val Val Leu His Thr Leu Asn Arg 
305                 310                 315                 320 


Ala Arg Phe Thr Val Ala Val Glu Thr Phe Leu Lys Thr Gly 
                325                 330                 


<210>  206
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  206

Met Thr Thr Leu Ser Lys Val Tyr Arg Asn Val Pro Thr Thr Ser Tyr 
1               5                   10                  15      


Gln Ile Thr Pro Leu Asp Phe Asp Ser Leu Asp Gly Val Pro Glu Ser 
            20                  25                  30          


His Ile Trp Ser Gln Pro Asp Glu Pro Gln Gln Lys Ile Gln Thr Gln 
        35                  40                  45              


Glu Pro Gln Glu Leu Ser Ile Pro Val Ile Asp Leu Thr Asp Pro Asn 
    50                  55                  60                  


Ala Leu Asp Leu Ile Gly Gln Ala Cys Lys Thr Trp Gly Ile Phe Gln 
65                  70                  75                  80  


Val Ile Asn His Gly Val Pro Leu Ala Leu Ile Lys Lys Leu Glu Ser 
                85                  90                  95      


Glu Ser Arg Arg Leu Phe Ala Leu Pro Thr Asp Glu Lys His Lys Val 
            100                 105                 110         


Leu Arg Ser Ala Asn Gly Val Thr Gly Tyr Gly Thr Ala Ser Ile Ser 
        115                 120                 125             


Lys Phe Phe Asp Lys Cys Met Trp His Glu Gly Phe Gly Ile Met Gly 
    130                 135                 140                 


Ser Cys Val Glu Asp Ala Lys Ile Leu Trp Pro Tyr Asp Tyr Lys Asn 
145                 150                 155                 160 


Phe Trp Tyr Val 
                


<210>  207
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  207

Met Thr Thr Leu Ser Glu Val Tyr Arg Asn Ala Pro Met Thr Ser Tyr 
1               5                   10                  15      


Gln Ile Thr Pro Leu Asp Phe Asp Ser Leu Asp Glu Ile Gln Thr Gln 
            20                  25                  30          


Glu Pro Gln Glu Leu Ser Ile Pro Ile Ile Asp Pro Asn Ala Leu Asp 
        35                  40                  45              


Leu Ile Gly Gln Ala Ser Lys Thr Trp Gly Ile Phe Gln Val Ile Asn 
    50                  55                  60                  


His Gly Val Pro Leu Ala Leu Ile Lys Lys Leu Glu Ser Glu Ser Arg 
65                  70                  75                  80  


Arg Leu Phe Ala Leu Pro Thr Asp Glu Lys His Lys Val Leu Arg Ser 
                85                  90                  95      


Ala Asn Ala Val Thr Gly Tyr Gly Thr Ala Arg Ile Ser Pro Phe Phe 
            100                 105                 110         


Asp Lys Cys Met Trp His Glu Gly Phe Ala Ile Met Gly Ser Cys Val 
        115                 120                 125             


Glu Asp Ala Lys Ala Leu Trp Pro His Asp Tyr Lys Asn Phe Trp 
    130                 135                 140             


<210>  208
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  208

Met Glu Pro Lys Gly Thr Gly Leu Gly Ser Ser Leu Leu Val Pro Ser 
1               5                   10                  15      


Val Gln Glu Leu Ala Arg Glu Pro Ile Thr Lys Val Pro Ala Arg Tyr 
            20                  25                  30          


Val Arg Leu Asp Gln Asp Pro Pro Ile Ile Ser Arg Pro Pro Ser Ser 
        35                  40                  45              


Leu Pro Lys Val Pro Val Ile Asp Met Ala Arg Leu Ser Ser Glu Asn 
    50                  55                  60                  


Ser Ala Asp His Glu Leu Glu Lys Leu His Ile Ala Cys Lys Asp Arg 
65                  70                  75                  80  


Gly Phe Phe Gln Ile Ile Asn His Gly Val Ser Ile Ser Leu Met Asp 
                85                  90                  95      


Lys Val Lys Glu Glu Thr Gln Glu Phe Phe Lys Leu Pro Met Glu Glu 
            100                 105                 110         


Lys Lys Lys Phe Trp Gln Thr Thr Asp Asp Val Glu Gly Phe Gly Gln 
        115                 120                 125             


Ala Phe Val Ile Ser Glu Glu Gln Lys Leu Asp Trp Ala Asp Ile Phe 
    130                 135                 140                 


Tyr Leu Ile Thr Leu Pro His Gly Ile Arg Lys Pro Tyr Leu Phe Pro 
145                 150                 155                 160 


Asn Leu Pro Leu Pro Phe Arg 
                165         


<210>  209
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  209

Met Ser Tyr Leu Ser Glu Ser Phe Arg Ala Pro Pro Pro Ser Pro Val 
1               5                   10                  15      


Ala Ser Gly Arg Arg Ser Phe Val Ala Asn Asp Asp Phe Leu Thr Glu 
            20                  25                  30          


Phe Leu His Asn Ser Leu Arg Val Pro Asp Leu Val Leu Pro Glu His 
        35                  40                  45              


Val Ser Pro Arg Gln Asn Thr Lys Ile Asn Asn Leu Pro Lys Leu Asp 
    50                  55                  60                  


Tyr Lys Ser Leu Asn Leu Leu His Asp His Lys Ala Ser Asp Thr Phe 
65                  70                  75                  80  


Asp Val Val Ala Lys Thr Gly Cys Phe Glu Leu Val Asn His Gly Ile 
                85                  90                  95      


Asn Asp Leu Leu Ile Arg Phe Val Ala Glu Phe Gly Gly Lys Ile Phe 
            100                 105                 110         


Glu Leu Ser Tyr Glu Glu Lys Lys Ala Val Ser Arg Ser Ser Asp Arg 
        115                 120                 125             


Met Tyr Gly Phe Val Glu Ser Asn Asp Asp Glu Lys Glu Thr Ser Glu 
    130                 135                 140                 


Glu Phe Val Trp Cys Arg Asp Asp Glu Leu Arg Ala Lys Met Glu Ala 
145                 150                 155                 160 


Ile Met Pro Leu Gln Tyr Ser Asn Phe Ser Glu Ser Leu Asp Ile Leu 
                165                 170                 175     


Ser Ser Glu Ile Glu Asn Ile Cys Gly Thr Ile Leu Lys Phe Leu His 
            180                 185                 190         


Lys Asn Thr Ser Pro Lys Ser Glu Ser Asp Asp Asp Glu Arg Glu Val 
        195                 200                 205             


Lys Gln Ile Val Gly Ser Val Cys Tyr Leu Tyr Arg His His Lys Asp 
    210                 215                 220                 


Pro Asn Thr Asn Pro Asn Asp Ser Glu His Thr Ser Ser Leu Arg Tyr 
225                 230                 235                 240 


Asp Met Ile Arg Met Leu Ile Arg Gly Ser Glu His Pro His Thr Leu 
                245                 250                 255     


Cys Leu His Val Cys Asp Gly Leu Ser Glu Phe His Val Tyr Ser Lys 
            260                 265                 270         


Lys Gly Arg Val Ser Phe Cys Pro Glu Lys Asp Ala Leu Val Ile Thr 
        275                 280                 285             


Ile Gly Asp Gln Leu Gln Lys Trp Ser Asp Gly Lys Tyr Lys His Val 
    290                 295                 300                 


Met Gly Arg Pro Ile Tyr Lys Gly Gly Asp Asp His Ile Ser Leu Ala 
305                 310                 315                 320 


Phe Met Tyr Asn Pro Pro Thr Leu Thr His Met Lys Glu Gln Lys Thr 
                325                 330                 335     


Ile Thr Ile Asp Ile Glu Tyr Ile Leu Ala Asn Thr Thr Ser Cys Ser 
            340                 345                 350         


Glu Ser Leu Asp Ile Leu Ser Ser Glu Ile Glu Asn Ile Cys Gly Thr 
        355                 360                 365             


Ile Leu Asn Phe Leu Leu Lys Asn Thr Ser Arg Lys Ser Gly Leu Asp 
    370                 375                 380                 


Asp Asp Glu Arg Glu Glu Lys Gln Ile Gly Gly Ser Val Cys Tyr Leu 
385                 390                 395                 400 


Tyr Arg His His Lys Asp Pro Asn Thr Asn Pro Asn Asp Ser Glu His 
                405                 410                 415     


Thr Ser Ser Trp Arg Tyr Asp Met Ile Arg Met Leu Ile Arg Gly Ser 
            420                 425                 430         


Glu His Pro His Thr Leu Cys Leu His Val Cys Asp Gly Leu Ser Glu 
        435                 440                 445             


Phe His Val Tyr Ser Lys Lys Gly Arg Val Ser Phe Cys Pro Glu Lys 
    450                 455                 460                 


Asp Ala Leu Val Ile Thr Ile Gly Asp Gln Leu Gln Lys Trp Ser Asp 
465                 470                 475                 480 


Gly Lys Tyr Lys His Val Met Gly Arg Pro Ile Tyr Asn Gly Gly Asp 
                485                 490                 495     


Asp His Ile Ser Leu Ala Phe Met Tyr Asn Pro Pro Ser Thr Leu Thr 
            500                 505                 510         


His Met Lys Glu His Lys Thr Ile Thr Ile Gly His Gln Ala Tyr Phe 
        515                 520                 525             


Phe Phe Ile Leu Ile Val Arg Phe Tyr Val Val Ser Cys 
    530                 535                 540     


<210>  210
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  210

Met Glu Leu Lys Gly Ile Gly Leu Gly Ser Ser Leu Leu Val Pro Ser 
1               5                   10                  15      


Val Gln Glu Leu Ala Lys Glu Pro Ile Thr Lys Val Pro Pro Arg Tyr 
            20                  25                  30          


Val Arg Leu Asp Gln Asp Pro Pro Ile Ile Ser Arg Pro Pro Ser Ser 
        35                  40                  45              


Ser Pro Asp Val Pro Val Ile Asp Met Ala Arg Leu Ser Ser Glu Asn 
    50                  55                  60                  


Ser Ala Asp Gln Glu Leu Glu Lys Leu His Leu Ala Cys Lys Asp Tyr 
65                  70                  75                  80  


Gly Phe Leu Gln Ile Ile Asn His Gly Val Ser Ile Ser Leu Met Asp 
                85                  90                  95      


Lys Val Lys Lys Glu Thr Gln Glu Phe Phe Lys Leu Ser Met Glu Glu 
            100                 105                 110         


Lys Lys Lys Leu Trp Gln Thr Thr Asp Asp Asn Glu Gly Phe Gly Gln 
        115                 120                 125             


Ala Phe Val Phe Ser Glu Glu Gln Lys Leu Asp Trp Ala Asp Ile Phe 
    130                 135                 140                 


Tyr Leu Thr Thr Leu Pro His Gly Ile Arg Lys Pro His Leu Phe Pro 
145                 150                 155                 160 


Asn Leu Pro Val Pro Phe Arg 
                165         


<210>  211
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  211

Met Ala Pro Ser Thr Pro Ile Ile Asn Ser Asn Ser Leu Asn Ile Leu 
1               5                   10                  15      


Asp Phe Val Val Asn Lys Gly His Gly Val Lys Gly Leu Ser Glu Leu 
            20                  25                  30          


Gly Leu Lys Thr Leu Pro His Gln Tyr Ile Gln Pro Pro Gln Glu Arg 
        35                  40                  45              


Phe Asp Ser Ser Asn Glu Glu Pro Asn Lys Asp Ser Ile Pro Val Ile 
    50                  55                  60                  


Asp Met Ser Ser Pro Asn Asp Pro His Val Ala Lys Ala Ile Cys Asp 
65                  70                  75                  80  


Ala Ala Gln Lys Trp Gly Phe Phe Gln Ile Val Asn His Gly Val Pro 
                85                  90                  95      


Ile His Val Leu Glu Asp Val Lys Asn Ala Thr His Lys Phe Phe Ala 
            100                 105                 110         


Leu Ala Pro Gln Glu Lys Gln Lys Tyr Ser Lys Ala Gln Ser Val Thr 
        115                 120                 125             


Asn Asn Val Arg Phe Gly Thr Ser Phe Thr Pro Glu Ala Glu Lys Ala 
    130                 135                 140                 


Leu Glu Trp Lys Asp Tyr Leu Ser Leu Phe Phe Val Ser Asn Asp Glu 
145                 150                 155                 160 


Ala Ala Ser Leu Trp Pro Pro Ile Cys Gly 
                165                 170 


<210>  212
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  212

Met Ala Pro Phe Leu Thr Asp Met His Glu Leu Lys Thr Phe Val Val 
1               5                   10                  15      


Asn Glu Gly Asn Gly Val Lys Gly Leu Ser Glu Leu Lys Ile Lys Thr 
            20                  25                  30          


Val Pro Glu Leu Phe Ile Gln Pro Leu Glu Lys Arg Leu Asp Met Ser 
        35                  40                  45              


Lys Val Val Leu Lys Glu Ser Ile Pro Val Ile Asp Met Ser Asn Tyr 
    50                  55                  60                  


Glu Asp Pro Glu Val Met Asp Ser Ile Cys Asp Ala Ala Glu Lys Trp 
65                  70                  75                  80  


Gly Phe Phe Gln Val Val Asn His Asp Val Pro Leu Ser Val Leu Glu 
                85                  90                  95      


Asp Val Lys Lys Ala Thr Arg Arg Phe Phe Glu Leu Pro Ala Asp Glu 
            100                 105                 110         


Lys Lys Lys Tyr Leu Phe Asn Asn Ser Pro Thr Lys Asn Val Arg Leu 
        115                 120                 125             


Leu Ser Ser Phe Val Pro Glu Val Asp Lys Ala Met Glu Trp Lys Asp 
    130                 135                 140                 


Tyr Leu Ser Cys Phe Tyr Val Ser Asp Asp Glu Ala Met Ala Phe Trp 
145                 150                 155                 160 


Pro Ser Val Cys Arg 
                165 


<210>  213
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  213

Met Ala Pro Ser Phe Ser Asp Glu Asn Ser Leu Thr Asn Phe Val Val 
1               5                   10                  15      


Lys Glu Gly Asn Gly Val Lys Gly Leu Val Asp Ser Gly Leu Thr Glu 
            20                  25                  30          


Val Pro Ser Arg Tyr Ile Gln Pro Pro His Asn Arg Ile Ser Lys Gln 
        35                  40                  45              


His Thr Thr Ala Ser Ile Asp Gln Ser Met Thr Ile Asp Leu Ser Glu 
    50                  55                  60                  


Leu Asp Gly Pro Asn His Asp Gln Val Val Lys Ser Ile Ala His Ala 
65                  70                  75                  80  


Ala Glu Thr Leu Gly Phe Phe Gln Val Val Asn His Gly Val Pro Leu 
                85                  90                  95      


Glu Leu Leu Asp Ser Leu Lys Val Ala Ala His Gln Phe Phe Asn Gln 
            100                 105                 110         


Pro Val Glu Lys Lys Ala Val Tyr Leu Lys Gly Val Ser Pro Ser Pro 
        115                 120                 125             


Met Val Lys Tyr Gly Thr Ser Phe Asn Pro Asp Lys Glu Lys Ala Leu 
    130                 135                 140                 


Glu Trp Lys Asp Tyr Val Ser Met Ile Tyr Thr Asn Asp Asp Asp Ala 
145                 150                 155                 160 


His Met Phe Trp Pro Asn Glu Cys Lys Glu Pro Pro Arg Asn Ser Arg 
                165                 170                 175     


Leu Glu Leu Phe Ser Leu Arg Thr Ala Ala Thr Lys His Phe Arg Ser 
            180                 185                 190         


Gly Leu Glu Gly Asp Ile Leu Gly Lys Leu Phe Gly Leu Ile Ser Val 
        195                 200                 205             


Ser Asp Lys Tyr Gly Leu Val Thr Asp Gly Arg Ser Gln Leu Phe Glu 
    210                 215                 220                 


Pro Asp Phe Ala His Val Pro Leu Phe Asn His Asp Trp Asp Ser Pro 
225                 230                 235                 240 


Ile Asn Met Ile Asp Trp Gly Ile Val Tyr Leu Gly Asn Ser Thr Ala 
                245                 250                 255     


Arg His Ser Val Pro Phe Ala Ser Ser Leu Glu Phe Tyr Met Glu Leu 
            260                 265                 270         


Tyr Val Thr Lys Glu Lys Asn Thr Cys Tyr Gln Val Cys Asn His Lys 
        275                 280                 285             


Glu Glu Ile Asp Leu Ser Ala Phe Trp Asn Lys Glu Ser Asp Ser Ala 
    290                 295                 300                 


Ser Gly Ser Leu Ile Val Gln Gly Glu Asp Gly Pro Thr His Met Phe 
305                 310                 315                 320 


Tyr Ile Phe Met Lys Asp Ala Val Asp Ile Ser Leu Glu Val Lys Phe 
                325                 330                 335     


Arg Thr Glu Thr Leu Gly Arg Lys Val Arg Gly Tyr Val Ile Ala His 
            340                 345                 350         


Tyr Gly Asp Asp Phe Leu Tyr Glu Cys Gln Cys Asp Pro Arg Gly Arg 
        355                 360                 365             


Asp Leu Tyr Ser Ala Leu Leu Phe Leu Ser Asp Gly Val Leu Glu Pro 
    370                 375                 380                 


Gly Thr Val Lys Leu Ile Lys Ser Val Met Ala Val Pro Thr Lys Gly 
385                 390                 395                 400 


Asn Leu Ile Ile Lys Ala Tyr Leu Glu Asp Val Gly Ser Gly Glu Val 
                405                 410                 415     


Ile Met Lys Asn Ser Cys Lys Leu Lys Pro Gln Leu Glu Ser Cys Arg 
            420                 425                 430         


Arg Phe Ser Thr Ile Ser Gly Ile Glu Gly Gly Asp Cys Asp Leu His 
        435                 440                 445             


Leu Ile Val Asp 
    450         


<210>  214
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  214

Met Thr Arg Ser Ile Ser Ile Thr Asn Thr Lys Ser Leu Asn Ile Leu 
1               5                   10                  15      


Asp Leu Val Val Ser Gly Ala Glu Leu Arg Gly Trp Lys Gly His Gly 
            20                  25                  30          


Val Lys Gly Leu Ala Glu Leu Gly Leu Lys Ala Leu Pro His Gln Tyr 
        35                  40                  45              


Ile Gln Pro His Gln Glu Arg Phe Ala Ser Thr Thr Asn Glu Pro Asn 
    50                  55                  60                  


Lys Tyr Phe Ile Pro Val Ile Gly Ile Ser Asn Trp Asp Tyr Leu Asn 
65                  70                  75                  80  


Val Ala Lys Ala Ile Cys Glu Ala Ala Ser Lys Trp Gly Phe Phe Gln 
                85                  90                  95      


Ile Val Asn His Gly Val Pro Ile His Val Leu Glu Asp Val Lys Phe 
            100                 105                 110         


Ala Thr Asn Lys Phe Phe Ala Leu Pro Leu Pro Pro Pro Glu Lys Val 
        115                 120                 125             


Ile Tyr Ser Lys Glu Gln Ser Val Thr Asn Asn Val Arg Phe Val Thr 
    130                 135                 140                 


Arg Phe Thr Pro Asp Ala Glu Lys Ala Leu Glu Trp Lys Asp Tyr Leu 
145                 150                 155                 160 


Phe 
    


<210>  215
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  215

Met Val Ile Ala Ile Leu Asp Lys Pro Lys Lys Gly Gln Ser Ile Asp 
1               5                   10                  15      


Lys Lys Lys Glu Lys Met Leu Pro Val Ile Asp Leu Ser Ser Ser Ser 
            20                  25                  30          


Glu Asp Arg Ile Ser Thr Ala His Ser Ile Arg Gln Ala Cys Thr Asp 
        35                  40                  45              


Tyr Gly Phe Phe Tyr Leu Ile Asn His Gly Val Asp Glu Gln Asn Val 
    50                  55                  60                  


Phe Glu Gln Ser Arg Leu Phe Phe Ser Leu Pro Leu Glu Asp Lys Met 
65                  70                  75                  80  


Lys Ser Ser Arg Asn Ile Gly Gly Asp Phe Gly Phe Ser Pro Leu Tyr 
                85                  90                  95      


Ala Glu Asn Leu Asp Ser Ser Ser Ser Ser Lys Thr Lys Gly Gly Asp 
            100                 105                 110         


Ser Lys Glu Thr Phe His Ile Gly Pro Leu Gln Asn Gln Leu Asn Gln 
        115                 120                 125             


Trp Pro Ser Gln Asp Leu Leu Pro Ser Trp Arg Ser Val Met Glu Thr 
    130                 135                 140                 


Tyr Tyr Ala Ser Leu Leu 
145                 150 


<210>  216
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  216

Met His Ser Ile Leu Lys Lys Asn Pro Asp Thr Ser Pro Ile Leu Asp 
1               5                   10                  15      


Ile Gln Arg Gln Arg Tyr Gln Asp Pro Glu Val Glu Lys Thr Met Asn 
            20                  25                  30          


Met Ile Gln Leu Pro Asp Leu Val Glu Val Asn Pro Gln Asn Tyr Glu 
        35                  40                  45              


Val Thr Ser Arg Glu Leu Thr Thr Ala Ile Thr Val Leu Gln Leu Phe 
    50                  55                  60                  


Leu Ser Ser Ser Lys Pro Val Leu Arg Phe Ala Val Val Gln Thr Leu 
65                  70                  75                  80  


Ser Lys Asp Glu Leu Leu Lys Gln Pro Ile Ala Ser Asn Asp Ser Asp 
                85                  90                  95      


Ser Ser Asp Val Asn Glu Ile Pro Thr Ala Val Ile Glu Val Ser Gln 
            100                 105                 110         


Asp Glu Leu Met Lys Asn Arg Pro Arg Lys Asp Gln Val Asn Gln Leu 
        115                 120                 125             


Lys Asp Ala Asn Ala Lys Pro Lys Tyr Arg Ile Gly Ser Ser Leu Lys 
    130                 135                 140                 


His Arg Ile Ala Ser Glu Met Cys Lys Asn Pro Lys Leu Gln Leu Leu 
145                 150                 155                 160 


Met Tyr Lys Ser Cys Ile Lys Leu Ile Val Cys Val His Pro Ala Glu 
                165                 170                 175     


Phe Gln Asn Tyr Asn Glu Glu Leu Asn Gln Asp Ser Ile Leu Val Ile 
            180                 185                 190         


Asp Met Ser Asn Phe Asp Asp Pro Asn Val Ala Asn Ala Ile Cys Ala 
        195                 200                 205             


Ala Ala Ser Lys Trp Gly Phe Phe Gln Ile Val Asn His Gly Val Pro 
    210                 215                 220                 


Ile Gln Val Leu Asp Asp Val Lys Asp Ala Thr Arg Lys Phe Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Lys Lys Phe Glu Ile Leu Lys Arg Lys Phe Ala Glu Lys 
                245                 250                 255     


Ala Leu Glu Trp Asn Asp Tyr Leu Ser Phe Phe Phe Val Leu Asp Val 
            260                 265                 270         


Glu Ala Ala Thr Leu Trp Pro Pro Val Cys Arg Ile Arg Ser Thr Thr 
        275                 280                 285             


Val Met Leu Pro Leu Phe Asn Leu Asp Leu Thr Ala Leu Met Val Pro 
    290                 295                 300                 


Ser Ser Asn Pro Asp Gly Gly Asn Cys Asp Val Ile Phe Ser Cys Asp 
305                 310                 315                 320 


Gly Asp Met Leu Val Ala Ser Thr Cys Lys Lys Asp Phe Ile Cys Thr 
                325                 330                 335     


Ile Phe Phe Val Lys Asp Arg Ser Ser Lys Ser Ser Gln Lys Asp Asp 
            340                 345                 350         


Gln Ser Val Glu Ser Pro Gly Ser Pro Arg Asn Gln Lys Leu Ile Gln 
        355                 360                 365             


Ile Thr Thr Arg Trp Asp Pro Ser Asp Ala Cys Lys Pro Asp Val Glu 
    370                 375                 380                 


Asp Ala Leu Ile Phe Tyr Pro Thr Ala Glu Glu Phe Glu Asp Thr Leu 
385                 390                 395                 400 


Gly Tyr Leu 
            


<210>  217
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  217

Met Glu Asp Asn Thr Asn Glu Ile Ile Asn Arg Ser Glu Tyr Gly Gly 
1               5                   10                  15      


Ser Ile Pro Val Asp Asn Val Gln Ala Leu Ala Ser Ser Lys Asp Leu 
            20                  25                  30          


Lys Asp Ile Pro Ser His Tyr Ile Arg Pro Glu Ile Glu Leu Asp Val 
        35                  40                  45              


Val Leu Thr Asp Glu Ser Leu Gln Ile Pro Val Ile Asp Ile Ser Lys 
    50                  55                  60                  


Leu Ala Val Ala Gly Gln Pro Gly Tyr Asp Asp Glu Leu Glu Asn Leu 
65                  70                  75                  80  


His Val Ala Cys Arg Asp Trp Gly Phe Phe Gln Ile Tyr Ile Leu Tyr 
                85                  90                  95      


Leu Phe Ser Asp Ser Ile Thr Met Asn Asn Ile Val Thr Leu Leu Val 
            100                 105                 110         


Ala Leu Leu Val Ile Ser Gln Thr Lys Thr Ser Leu Cys Asp Asn Glu 
        115                 120                 125             


Pro Leu Val Leu Gly Tyr Tyr Glu Glu Thr Cys Pro Leu Leu Glu Glu 
    130                 135                 140                 


Ile Val Gln Arg Gln Val Glu Ile Ala Val His Lys Glu Pro Arg Met 
145                 150                 155                 160 


Ala Ala Ser Leu Leu Arg Leu Asn Phe His Asp Cys Phe Val Met Gly 
                165                 170                 175     


Cys Asn Ala Ser Val Leu Leu Asp Asp Phe Glu Gly Val Gln Ser Glu 
            180                 185                 190         


Lys Asn Ala Gly Pro Asn Leu Asn Ser Leu Arg Gly Phe Glu Val Ile 
        195                 200                 205             


Asp Glu Ile Lys Tyr Leu Val Glu Glu Ala Cys Pro Cys Thr Val Ser 
    210                 215                 220                 


Cys Ala Asp Leu Leu Ala Ile Val Ala Arg Asp Ala Val Ala Leu Arg 
225                 230                 235                 240 


Gly Gly Pro Lys Trp Asn Val Tyr Leu Gly Arg Lys Asp Ser Met Lys 
                245                 250                 255     


Ala Ser Leu Asp Gly Ala Asn Gln Leu Ile Pro Ala Pro Asn Ser Ser 
            260                 265                 270         


Leu Glu Thr Leu Ile Ala Asn Phe Arg Tyr Gln Gly Leu Asn Ile Gln 
        275                 280                 285             


Asp Leu Val Ala Leu Ser Gly Ser His Thr Ile Gly Lys Ala Gln Cys 
    290                 295                 300                 


Lys Ser Phe Arg Gln Arg Ile Tyr Asp Tyr Asp Asp Ser Glu Lys Asn 
305                 310                 315                 320 


Ser Tyr His His His His Asn Asp Asn Glu Phe Gln Arg Val Leu Lys 
                325                 330                 335     


Ser Ile Cys Pro Lys Ser Gly Lys Asp Asn Ala Leu Ala Pro Leu Asp 
            340                 345                 350         


Ile Ala Thr Pro Leu Arg Phe Asp Asn His Tyr Phe Gln Asn Ile Lys 
        355                 360                 365             


Gln Gly Leu Gly Leu Leu Ile Ser Asp Asn Val Leu Ile Ser Glu Asp 
    370                 375                 380                 


Ile Glu Gly Glu Ile Arg Asp Leu Val Trp Glu Phe Ala Ser Asp Glu 
385                 390                 395                 400 


Lys Lys Met Ile Pro Gly Thr Asn Leu His Gln Phe Asp Val His Asn 
                405                 410                 415     


Asp Gly Phe Phe Ala His Leu Pro Leu Arg Tyr Asp Asp Gly Val Ile 
            420                 425                 430         


Leu Asn Met Ala Ser Val Arg Met Pro Tyr Glu Lys Phe Ala Glu Phe 
        435                 440                 445             


Leu Glu Glu Lys Val Gly Asn Tyr Phe Gln Gly Leu Tyr Tyr Lys Val 
    450                 455                 460                 


Pro Asn Val Glu Leu Glu Lys Gly Leu Val Lys Val Ser Asp Asp Lys 
465                 470                 475                 480 


Gln Ile Ala His Met Phe Asp Val Ala Glu Leu Tyr Gly Arg Leu Asp 
                485                 490                 495     


Leu Tyr Leu Asp His Leu Asp Met Asp Leu Ser Glu Tyr Leu Glu Lys 
            500                 505                 510         


Ala Asp Thr Asp Asp Met Asp Glu Cys Val Tyr Arg Ala Lys Gly Pro 
        515                 520                 525             


Pro Lys Pro Arg Tyr Cys Asn Lys Phe Ser Val Asp Glu Met Val Asn 
    530                 535                 540                 


Trp Ala Glu Met Glu Val Glu Tyr Glu Ala Ser Ser Ser Asn His Pro 
545                 550                 555                 560 


Arg Thr Ser Ala Glu Gly Asp Val Pro Arg Ala Ser Glu Asn Val Glu 
                565                 570                 575     


Val Pro Met Thr Ser Ser Glu Val Asp Val Ala Thr Thr Arg Val Asp 
            580                 585                 590         


Gly Tyr Asn Val Arg Lys Glu Leu Ile Glu Leu Arg Lys Arg Ile Lys 
        595                 600                 605             


Ala Ser Arg Leu Lys Glu Pro Glu Ser Val Thr Glu Met Asn Glu Pro 
    610                 615                 620                 


Asn Asp Gln Asn Gln Ile His Thr Glu Asn Thr Asp Ser His Arg Ser 
625                 630                 635                 640 


Glu Thr Met Ile Glu His Asp Leu Phe Met Asn Thr Leu Met Arg Arg 
                645                 650                 655     


Leu Gln Ser Ser Asp Glu Asn Gly Met His Gln Asp Pro Phe Val Cys 
            660                 665                 670         


Val Glu Lys His Val Asp Arg Tyr Pro Val Tyr Asp Glu Ser Thr His 
        675                 680                 685             


Trp Arg Leu Arg His Pro Lys Lys Asn Met Leu Thr Gly Thr Gln Leu 
    690                 695                 700                 


Glu Ile Ala Lys Gln Ile Gln Gly Gln Gly Ser Thr Pro Gln Thr Ala 
705                 710                 715                 720 


Leu Asp Leu Asp Asp Ala 
                725     


<210>  218
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  218

Met Glu Ala Cys Ala Asn Trp Phe Ser Leu Ala Ile Lys Asp Asp Asp 
1               5                   10                  15      


Lys Gln Gln Cys Ser Ser Ser His Lys Leu Asp Asp Ser Arg Leu Ser 
            20                  25                  30          


Asn Asp Ser Arg Lys Glu Ser Glu Gln Cys Trp His Leu Thr Thr Pro 
        35                  40                  45              


Arg Thr Ser Tyr Lys Ile Asp His Lys His Pro Glu Ala Asp Ile Ala 
    50                  55                  60                  


Gly Glu Thr Ala Ala Thr Phe Ala Ala Ser Ser Ile Ala Phe Lys Tyr 
65                  70                  75                  80  


Ser Asp Pro Asp Tyr Pro Asn Ile Leu Leu Lys His Thr Lys Gln Thr 
                85                  90                  95      


Val His Pro Thr Glu Phe Gln Asn Tyr Asn Glu Glu Ser Asn Gln Asp 
            100                 105                 110         


Ser Ile Pro Val Ile Asn Met Ser Asn Phe Asp Asp Pro Asn Val Ala 
        115                 120                 125             


Asn Ala Ile Cys Ala Ala Ala Ser Lys Trp Gly Phe Phe Gln Ile Val 
    130                 135                 140                 


Asn His Gly Val Pro Ile His Val Leu Asp Asp Phe Lys Asp Ala Met 
145                 150                 155                 160 


Asn Leu Ser Cys Cys Thr Lys Phe Leu Glu Arg Ser His Val His Pro 
                165                 170                 175     


Lys Val Val Met Cys Asp Val Asp Ala Ser Ile Glu Ala Trp Gln Pro 
            180                 185                 190         


Gly Pro Leu Ala Lys Asn Lys Ala Ile Thr Glu Ala Glu Val Ile Trp 
        195                 200                 205             


Ala Asp Arg Tyr Ser Ala Val Ala Cys Lys His Ile 
    210                 215                 220 


<210>  219
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  219

Met Ser Ile Asn Glu Glu Tyr Arg Gly Ser His Phe His Glu Ala Thr 
1               5                   10                  15      


Phe Ile Asn Gln Asn Gly Glu Leu Gln Thr Ser Lys Ile Pro Val Val 
            20                  25                  30          


Gln Glu Leu Ala Arg Glu Gly Leu Thr Asn His Phe Pro Lys Arg Phe 
        35                  40                  45              


Ile Ser Leu Pro Gln Arg Val Asp Thr Ile Ile Phe Glu Thr Pro Pro 
    50                  55                  60                  


Val Ile Asp Ile Ala Lys Leu Lys His Asn Asp Thr Arg Lys Met Glu 
65                  70                  75                  80  


Leu Gln Lys Leu Ala Glu Ala Ala Lys Glu Trp Gly Val Phe Leu Ile 
                85                  90                  95      


Lys Asn His Gly Val Asp Asp Thr Val Leu Asp Asp Val Lys Asp Val 
            100                 105                 110         


Val Lys Gly Phe Phe Ala Leu Ser Phe Glu Glu Lys Lys Val Asn Val 
        115                 120                 125             


Gly Met Tyr Arg Ser Val Asp Asn Met Gly Tyr Gly Lys Thr His Val 
    130                 135                 140                 


Met Ser Glu Asp Gln Pro Leu Asp Trp Val Asp Arg Leu Thr Ile Lys 
145                 150                 155                 160 


Ala Ala Pro Val Asp Glu Ser Thr Asn Asp Asp Leu Arg Val Trp Pro 
                165                 170                 175     


Arg Lys Pro Thr Asn Phe Arg Asp Tyr Phe Asn Thr Phe Ile Glu Ile 
            180                 185                 190         


Glu Ile Ile Ser Leu Phe Leu Val Tyr Phe Asp Leu Lys Ile Arg Lys 
        195                 200                 205             


Leu Gly Gln His Ala Trp His Arg Val Arg Thr Gln Leu Asp Ala Glu 
    210                 215                 220                 


Arg Ile Ser Leu Ala Tyr Phe Tyr Asn Pro Pro Pro Gln Cys Glu Ile 
225                 230                 235                 240 


Gly Pro Met Val Asn Ser Gly Ser Met Glu Glu Ile Tyr Lys Lys Val 
                245                 250                 255     


Val Val Glu Asp Tyr Val Ser His Phe Asn Lys Ile Ser Pro Thr Thr 
            260                 265                 270         


Ser Lys Glu Ala Ile Met Tyr Ala Lys Val Lys 
        275                 280             


<210>  220
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  220

Met Leu Thr Pro Ile Lys Phe Ala Gly Cys Asp Gly Ala Leu Ala Asn 
1               5                   10                  15      


Ser Ser Cys Thr Glu Val Glu Asn Trp Arg Lys Ala Asn Asn Gly Tyr 
            20                  25                  30          


Ile Gly Tyr Ser Phe Leu Phe Asp Cys Val Ile Ala Ser Cys Cys Ser 
        35                  40                  45              


Tyr Ser Gln Gln Leu Phe Lys Pro Thr Ile Leu His Arg Tyr Gly Gln 
    50                  55                  60                  


Gln Ile Gln Thr Thr Ala Gly Ile Ser Lys Ser Lys Ser Thr Glu Asp 
65                  70                  75                  80  


Gln Leu Ser Arg Arg Cys Met Lys Gly Ser Ser His Asp Val Asp Gly 
                85                  90                  95      


Gly Lys Ala Leu Asp Ala Asn Phe His Val Met Val Ile Val Ser Val 
            100                 105                 110         


Thr Ser Val Thr Ser Ala Asp Ile Ala Gln Gly Tyr Thr Asn Gln Thr 
        115                 120                 125             


Val Glu Glu Glu Phe Val Ser Pro Arg Ile Ser Ser Arg Arg Asn Arg 
    130                 135                 140                 


Ser Ala Ala Arg Asp Pro Leu Leu Ile Tyr Leu Arg Ile Arg Ala Ser 
145                 150                 155                 160 


Thr Ser Met Asp Lys Glu Asn Arg Ala Gly Asp Ala Lys Asn Glu Gln 
                165                 170                 175     


Pro Glu Lys Val Ile Lys Lys Lys Leu Asp Lys Asp Gln Lys Ile Leu 
            180                 185                 190         


Asp Asn Asp Gly Phe Lys Leu Ser Asn Asn His Leu Thr Gly Thr Ile 
        195                 200                 205             


Ser Gly Pro Met Ile Ala Arg Met Met Asn Leu Gln Ser Val His Pro 
    210                 215                 220                 


Ala Glu Phe Gln Asn Tyr Asn Glu Glu Pro Asn Gln Asp Ser Ile Pro 
225                 230                 235                 240 


Val Ile Asp Met Ser Asn Phe Asp Asp Pro Asn Val Ala Asn Ala Ile 
                245                 250                 255     


Cys Ala Thr Ala Ser Lys Trp Gly Phe Phe Gln Ile Val Asn His 
            260                 265                 270     


<210>  221
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  221

Met Val Leu Asp Asn Thr Ser Leu Ser Gln Pro Asn Tyr Asp Arg Lys 
1               5                   10                  15      


Ala Glu Leu Lys Ala Phe Asp Glu Thr Lys Thr Gly Val Lys Gly Leu 
            20                  25                  30          


Val Asp Ala Gly Ile Thr Gln Val Pro Arg Ile Phe His Val Pro Ser 
        35                  40                  45              


Pro Gln Asn Leu Asn Ser Lys Gln Ser Cys Pro Lys Leu Ile Leu Pro 
    50                  55                  60                  


Thr Ile Asp Leu Glu Gly Ile Asn Glu Asp Ser Val Arg Arg Lys Glu 
65                  70                  75                  80  


Val Ile Gln Lys Val Asn Asp Ala Leu Lys Thr Trp Gly Phe Phe Gln 
                85                  90                  95      


Ile Val Asn His Gly Ile Ser Asn Ser Thr Leu Glu Glu Val Lys Lys 
            100                 105                 110         


Gly Val Arg Glu Phe Phe Glu Gln Asp Asp Glu Val Lys Lys Glu Trp 
        115                 120                 125             


Tyr Thr Arg Asp Met Ser Gly Lys Thr Arg Val Val Tyr Asn Ser Asn 
    130                 135                 140                 


Phe Asp Leu Tyr Ala Ala Pro Val Thr Asn Trp Arg Asp Thr Phe Phe 
145                 150                 155                 160 


Cys Met Met Ala Pro Tyr His Pro Glu Pro His Glu Leu Pro Gln Pro 
                165                 170                 175     


Cys Arg Phe 
            


<210>  222
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (279)..(279)
<223>  Xaa can be any naturally occurring amino acid

<400>  222

Met Ser Tyr Leu Ser Glu Ser Phe Arg Ala Pro Pro Pro Ser Pro Val 
1               5                   10                  15      


Ala Ser Gly Arg Arg Ser Phe Val Ala Asn Asp Asp Phe Leu Thr Glu 
            20                  25                  30          


Phe Leu His Asn Ser Leu Arg Val Pro Asp Leu Val Leu Pro Glu His 
        35                  40                  45              


Val Ser Pro Arg Gln Asn Thr Lys Ile Asn Asn Leu Pro Lys Leu Asp 
    50                  55                  60                  


Tyr Lys Ser Leu Asn Leu Leu His Asp His Lys Ala Ser Asp Thr Phe 
65                  70                  75                  80  


Asp Val Val Ala Lys Thr Gly Cys Phe Glu Leu Val Asn His Gly Ile 
                85                  90                  95      


Asn Asp Leu Leu Ile Arg Phe Val Ala Glu Phe Gly Gly Lys Ile Phe 
            100                 105                 110         


Glu Leu Ser Tyr Glu Glu Lys Lys Ala Val Ser Arg Ser Ser Asp Arg 
        115                 120                 125             


Met Tyr Gly Phe Val Glu Ser Asn Asp Asp Glu Lys Glu Thr Ser Glu 
    130                 135                 140                 


Glu Phe Val Trp Cys Arg Asp Asp Glu Leu Arg Ala Lys Met Glu Ala 
145                 150                 155                 160 


Ile Met Pro Leu Gln Tyr Ser Asn Phe Ser Glu Ser Leu Asp Ile Leu 
                165                 170                 175     


Ser Ser Glu Ile Glu Asn Ile Cys Gly Thr Ile Leu Lys Phe Leu His 
            180                 185                 190         


Lys Asn Thr Ser Pro Lys Ser Glu Ser Asp Asp Asp Glu Arg Glu Val 
        195                 200                 205             


Lys Gln Ile Val Gly Ser Val Cys Tyr Leu Tyr Arg His His Lys Asp 
    210                 215                 220                 


Pro Asn Thr Asn Pro Asn Asp Ser Glu His Thr Ser Ser Leu Arg Tyr 
225                 230                 235                 240 


Asp Met Ile Arg Met Leu Ile Arg Gly Ser Glu His Pro His Thr Leu 
                245                 250                 255     


Cys Leu His Val Cys Asp Gly Leu Ser Glu Phe His Val Tyr Ser Lys 
            260                 265                 270         


Lys Gly Arg Val Ser Phe Xaa Asn Lys Lys Cys Lys Val Met Cys Arg 
        275                 280                 285             


Met Gly Ser Gly Asp Arg Trp Asn Trp Tyr Arg Ala Pro Glu Ser Ser 
    290                 295                 300                 


Cys Glu Leu Glu Glu Leu Asp Phe Leu Val Asn Val Val Glu Leu Val 
305                 310                 315                 320 


Glu Leu Ser Gly Arg Lys Asp Lys Trp Asn Trp Ile Gly Asp Lys Ser 
                325                 330                 335     


Gly Lys Phe Ser Val Arg Ser Val Arg Ser Leu Leu Tyr Ser Val Ser 
            340                 345                 350         


Asp Phe Ser Asn Ile Tyr Val Leu Lys Trp Cys Lys Trp Ile Pro Ala 
        355                 360                 365             


Lys Cys Asn Ile Phe Met Trp Gln Ala Glu Met Ser Arg Ile Pro Ser 
    370                 375                 380                 


Ala Asp Ser Leu Ile Arg Arg Lys Met Val Gly Ile Glu Gly Met Cys 
385                 390                 395                 400 


Ser Ile Cys Gly Glu Gly Pro Glu Ser Val Glu His Leu Phe Thr Ser 
                405                 410                 415     


Cys Trp Val Ala Met Met Val Trp Asn His Ile Cys Asn Trp Thr Arg 
            420                 425                 430         


Val Gln Arg Phe Phe Ala Phe Ser Phe Arg Asp Leu Ile Glu Val His 
        435                 440                 445             


Glu His Val Gly Leu Lys Gly Lys Ala Lys Leu Val Phe Gln Gly Ile 
    450                 455                 460                 


Val Ile Ile Ser Cys Trp Ala Ile Trp Arg Ala Arg Asn Lys Arg Arg 
465                 470                 475                 480 


Phe Glu Gly Ile Asp Val Lys Ile Val Glu Val Ile Ser Glu Ile Lys 
                485                 490                 495     


Ser Leu Gly Phe Leu Trp Ala Ser Ser Arg Ala Lys Leu Ser Arg Phe 
            500                 505                 510         


Ser Trp Ser Asp Trp Cys Lys Tyr Glu Ile Val 
        515                 520             


<210>  223
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  223

Met Val Leu Asp Asn Met Ser Leu Ser Lys Pro Ser Tyr Asp Arg Lys 
1               5                   10                  15      


Ala Glu Leu Lys Ala Phe Asp Glu Thr Lys Thr Gly Val Lys Gly Leu 
            20                  25                  30          


Val Asp Ala Gly Ile Thr Gln Val Pro Arg Ile Phe His Val Pro Ser 
        35                  40                  45              


Pro Gln Asn Leu Lys Ser Asn Gln Pro Cys Pro Lys Pro Ser Leu Pro 
    50                  55                  60                  


Thr Ile Asp Leu Glu Gly Ile His Glu Asp Ser Leu Arg Arg Lys Glu 
65                  70                  75                  80  


Val Ile Gln Lys Val Lys Asp Ala Leu Glu Thr Trp Gly Phe Phe Gln 
                85                  90                  95      


Ile Val Asn His Gly Ile Ser Asn Ser Met Leu Glu Glu Val Lys Lys 
            100                 105                 110         


Gly Val Arg Gly Phe Phe Glu Gln Asp Asp Glu Val Lys Lys Glu Trp 
        115                 120                 125             


Tyr Thr Arg Asp Phe Ser Gly Asn Arg Lys Leu Ile Thr Asn Asp Lys 
    130                 135                 140                 


Phe Val Ser Ala Gln His Arg Val Leu Ala Asn Lys Ile Gly Pro Arg 
145                 150                 155                 160 


Val Ser Ala Val Ser Phe Phe Thr Thr Ser Trp Ile Pro Thr Leu Lys 
                165                 170                 175     


Val Phe Glu Pro Ile Lys Glu Leu Leu Ser Lys Asp Asn Pro Pro Lys 
            180                 185                 190         


Tyr Arg Gly Thr Thr Val Lys Glu Tyr Val Glu Tyr Ile Asn Lys Lys 
        195                 200                 205             


Gly Leu Asp Glu Thr Ser Ala Phe Leu His Leu Lys Leu 
    210                 215                 220     


<210>  224
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  224

Met Val Leu Asp Asn Met Ser Leu Ser Lys Pro Ser Tyr Asp Arg Lys 
1               5                   10                  15      


Ala Glu Leu Lys Ala Phe Asp Glu Thr Lys Thr Gly Val Lys Gly Leu 
            20                  25                  30          


Val Asp Ala Gly Ile Thr Gln Val Pro Arg Ile Phe His Val Pro Ser 
        35                  40                  45              


Pro Gln Asn Leu Lys Ser Asn Gln Pro Cys Pro Lys Pro Ser Leu Pro 
    50                  55                  60                  


Thr Ile Asp Leu Glu Gly Ile His Glu Asp Ser Leu Arg Arg Lys Glu 
65                  70                  75                  80  


Val Ile Gln Lys Val Lys Asp Ala Leu Glu Thr Trp Gly Phe Phe Gln 
                85                  90                  95      


Ile Val Asn His Gly Ile Ser Asn Ser Met Leu Glu Glu Val Lys Lys 
            100                 105                 110         


Gly Val Arg Gly Phe Phe Glu Gln Asp Asp Glu Val Lys Lys Glu Trp 
        115                 120                 125             


Tyr Thr Arg Asp Phe Ser Gly Asn Arg Lys Val Leu Tyr Asn Ser Asn 
    130                 135                 140                 


Phe Asp Leu Phe Val Ala Pro Val Thr Asn Trp Arg Asp Thr Phe Phe 
145                 150                 155                 160 


Cys Met Met Ala Pro Tyr Pro Pro Glu Ser His Glu Leu Pro Gln Pro 
                165                 170                 175     


Cys Arg Phe Gln Leu 
            180     


<210>  225
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  225

Met Val Leu Asp Asn Thr Ser Leu Ser Lys Pro Asn Tyr Asp Arg Lys 
1               5                   10                  15      


Ala Glu Leu Lys Ala Phe Asp Gln Thr Lys Thr Cys Val Lys Gly Leu 
            20                  25                  30          


Val Asp Thr Gly Ile Thr Gln Val Pro Arg Ile Phe His Val Pro Pro 
        35                  40                  45              


Pro Gln Asn Leu Asn Ser Asn Gln Pro Cys Pro Lys Pro Ser Phe Pro 
    50                  55                  60                  


Thr Ile Asp Leu Glu Gly Ile Asn Glu Asp Gln Ile Lys Arg Lys Lys 
65                  70                  75                  80  


Val Ile Lys Glu Val Asn Asp Ala Leu Glu Ser Trp Gly Phe Phe Gln 
                85                  90                  95      


Ile Val Asn His Gly Ile Ser Asn Ser Thr Leu Glu Glu Val Lys Lys 
            100                 105                 110         


Gly Val Arg Gly Phe Phe Glu Gln Asp Asp Glu Val Lys Lys Glu Trp 
        115                 120                 125             


Tyr Thr Arg Asp Met Ser Gly Lys Thr Arg Val Val Tyr Asn Ser Asn 
    130                 135                 140                 


Phe Asp Leu Tyr Ala Ala Pro Val Thr Asn Trp Arg Asp Thr Phe Phe 
145                 150                 155                 160 


Cys Ser Met Ala Pro Asn Pro Pro Glu Pro His Lys Leu Pro Gln Pro 
                165                 170                 175     


Cys Arg Leu Val Phe 
            180     


<210>  226
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  226

Met Ala Ser Ser Thr Gln Asn His Gln Gln His His Phe Pro Asn Thr 
1               5                   10                  15      


Thr Thr Ser Ala Pro Pro Pro Thr Pro Ser Thr Thr His Pro Asn Pro 
            20                  25                  30          


Ala Thr Ser Ser Ala Ala Thr Asp Leu Leu Ser Arg Leu Leu Asn Arg 
        35                  40                  45              


Leu Pro Pro Thr Leu Ser Ala Thr Pro Leu Arg Arg Lys Ser Ser Leu 
    50                  55                  60                  


Thr Pro Thr Thr Ile Ser Pro Pro Ile Ile Pro Tyr Thr Asp Leu Asn 
65                  70                  75                  80  


Ser Thr Ile Ser Thr Thr Leu His Ser Ile Ser Glu Leu Gly Tyr Phe 
                85                  90                  95      


Gln Leu Thr Asp His Pro Ile Pro Pro His Leu Ala His Thr Ala Gln 
            100                 105                 110         


Lys Glu Ser Leu Ser Ile Phe Lys Leu Ser Arg Gln Glu Lys Lys His 
        115                 120                 125             


His Phe Ser Lys Asn Trp Pro Ile Gly Phe Thr Asn Asn Asn Glu Asp 
    130                 135                 140                 


Glu Asp His Glu Asp Glu Asp Asp Asp Ser Thr Glu Ser Leu Phe Leu 
145                 150                 155                 160 


Asp Ser Asp Ser Leu Ser Asp Ser Ser Asp Glu Phe Ser Leu Ser Ser 
                165                 170                 175     


Leu His Gly Phe Met His Ala Met Glu Lys Val Gly Leu Ser Val Val 
            180                 185                 190         


Glu Gly Leu Thr Cys Ala Met Gly Leu Val Lys Asp Gly Thr Asp Gly 
        195                 200                 205             


Val Cys Ser Leu Leu Trp Leu Gly Asp Asn Glu Gly Gly Asp Gln Met 
    210                 215                 220                 


Leu Gly Ser Gly Ser Gly Lys Phe Tyr Pro Tyr Val Val Gly Leu His 
225                 230                 235                 240 


Tyr Met Phe Ser Ser Gly Arg Cys Gly Leu Leu Ser Asp Ser Gly Leu 
                245                 250                 255     


Val Ser Val Lys Thr Glu Val Asp Ser Ile Leu Val Thr Val Gly Asp 
            260                 265                 270         


Ile Ala Gln Val Trp Ser Asn Gly Lys Leu Lys Lys Val Arg Gly Lys 
        275                 280                 285             


Pro Thr Ile Ser Met Glu Glu Gly His Thr Ser Ser Ser Leu Ser Met 
    290                 295                 300                 


Ser Leu Leu Val Thr Leu Pro Leu Glu Ser Thr Val Ser Pro Leu Leu 
305                 310                 315                 320 


Pro Arg Ala Val Val Ile Ser Asn His Asp Asp Thr Asp Asp Asn Asp 
                325                 330                 335     


Asn Gln Asn Gln Asp Asp Gln Asn Glu Ser Ile Glu Glu Ser Met Phe 
            340                 345                 350         


Ser Ser Phe Ser Phe Glu Asp Tyr Ala Trp Arg Val Tyr His Glu Arg 
        355                 360                 365             


Val His Leu Lys Asp Pro Leu Asp Arg Tyr Arg Ile Gln Ala 
    370                 375                 380         


<210>  227
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  227

Met Ala Ser Leu Thr Thr Glu His Lys Tyr Asp Arg Leu Lys Glu Val 
1               5                   10                  15      


Lys Gln Phe Asp Glu Ser Lys Ile Gly Val Lys Gly Leu Leu Asp Thr 
            20                  25                  30          


Gly Ile Thr Thr Ile Pro Ser Phe Phe His Gln Pro Pro Glu Asn Leu 
        35                  40                  45              


Pro Ser Pro Gln Pro Lys Asn Gln Pro Arg Leu Thr Val Pro Val Ile 
    50                  55                  60                  


Asp Leu Ser Gln Asp Arg Ser Thr Val Val Asp Glu Ile Arg Gly Ala 
65                  70                  75                  80  


Ser Ser Thr Leu Gly Phe Phe Gln Ile Val Asn His Ser Ile Ser Val 
                85                  90                  95      


Thr Ser Ile Glu Ser Val Ile Lys Asp Met Lys Asn Phe Tyr Glu Gln 
            100                 105                 110         


Thr Thr Glu Tyr Lys Met Lys Phe Tyr Asn Arg Glu Val Glu Lys Gly 
        115                 120                 125             


Val Thr Tyr Ser Thr Asn Met Asp Leu Tyr Lys Ser Lys Ala Ala Ser 
    130                 135                 140                 


Trp Arg Asp Thr Ile Gln Asp Ile Ser Ser Arg Thr Ser Ala Ile Lys 
145                 150                 155                 160 


Ser Leu Gln Ser Thr Val Asp Arg Leu Arg Ala Gln Ile 
                165                 170             


<210>  228
<211>  1493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  228

Met Asp Gly Ser Asp Ile Tyr Lys Ala Ala Asn Ser Ile Arg Leu Gly 
1               5                   10                  15      


Ser Leu Arg Ala Gly Ser Ser Ser Arg Ala Ser Ser Leu Arg Asn Gly 
            20                  25                  30          


Ser Thr Ser Val Trp Arg Asn Ser Gly Met Asp Ala Phe Ser Lys Ser 
        35                  40                  45              


Val Arg Glu Glu Asp Asp Glu Glu Ala Leu Lys Trp Ala Ser Leu Glu 
    50                  55                  60                  


Lys Leu Pro Thr Phe Asp Arg Leu Lys Lys Gly Leu Leu Phe Gly Ser 
65                  70                  75                  80  


Thr Gly Pro Ser Asn Glu Val Asp Val Asp Asn Leu Gly Ala Asn Asp 
                85                  90                  95      


Arg Arg His Ile Leu Asp Arg Leu Val Lys Thr Ala Asp Glu Asp Asn 
            100                 105                 110         


Glu Gly Phe Leu Leu Lys Leu Arg Asn Arg Leu Asp Arg Val Gly Ile 
        115                 120                 125             


Glu Leu Pro Thr Ile Glu Val Lys Tyr Glu His Val Thr Val Glu Ala 
    130                 135                 140                 


Asp Val Asn Thr Gly Ser Arg Ala Leu Pro Ser Phe Ile Asn Phe His 
145                 150                 155                 160 


Ile Glu Leu Val Glu Val Leu Leu Gly Leu Phe His Leu Leu Pro Asn 
                165                 170                 175     


Ser Lys Arg His Ile Thr Ile Leu Asp Asp Val Ser Gly Val Val Lys 
            180                 185                 190         


Pro Lys Arg Met Thr Leu Leu Leu Gly Pro Pro Ser Ser Gly Lys Thr 
        195                 200                 205             


Ser Leu Leu Leu Ala Met Ala Gly Thr Leu Ala Lys Glu Leu Lys Cys 
    210                 215                 220                 


Ser Gly Lys Val Thr Tyr Asn Gly His Glu Leu His Glu Phe Val Pro 
225                 230                 235                 240 


Glu Arg Thr Ser Ala Tyr Ile Ser Gln Asn Asp Val His Ile Gly Glu 
                245                 250                 255     


Met Thr Val Arg Glu Thr Leu Ala Phe Ser Ala Arg Cys Gln Gly Val 
            260                 265                 270         


Gly Ser Arg Tyr Asp Met Leu Ala Glu Leu Ser Arg Arg Glu Arg Asp 
        275                 280                 285             


Ala Asn Ile Lys Pro Asp Pro Asp Leu Asp Ile Phe Met Lys Ala Ala 
    290                 295                 300                 


Ala Thr Glu Gly Gln Glu Ala Asn Val Val Thr Asp Tyr Thr Leu Lys 
305                 310                 315                 320 


Leu Leu Gly Leu Asp Ile Cys Ala Asp Thr Met Val Gly Asp Gln Met 
                325                 330                 335     


Ile Arg Gly Ile Ser Gly Gly Gln Arg Lys Arg Val Thr Thr Gly Glu 
            340                 345                 350         


Met Ile Val Gly Pro Ser Lys Val Leu Leu Met Asp Glu Ile Ser Thr 
        355                 360                 365             


Gly Leu Asp Ser Ser Thr Thr Phe Gln Ile Val Lys Ser Leu Lys Gln 
    370                 375                 380                 


Phe Ile His Ile Leu Glu Gly Thr Ala Val Ile Ser Leu Leu Gln Pro 
385                 390                 395                 400 


Ala Pro Glu Thr Tyr Asp Leu Phe Asp Asp Ile Ile Leu Leu Thr Asp 
                405                 410                 415     


Gly Lys Ile Val Tyr Gln Gly Pro Arg Glu His Val Leu Glu Phe Phe 
            420                 425                 430         


Glu Ser Met Gly Phe Lys Cys Pro Glu Arg Lys Gly Val Ala Asp Phe 
        435                 440                 445             


Leu Gln Glu Val Thr Ser Lys Lys Asp Gln Gln Gln Tyr Trp Lys Arg 
    450                 455                 460                 


Arg Asp Met Pro Tyr Arg Phe Val Thr Ala Lys Glu Phe Ala Glu Ala 
465                 470                 475                 480 


Tyr Gln Ser Phe His Val Gly Arg Lys Leu Ala Thr Asp Leu Ala Thr 
                485                 490                 495     


Pro Tyr Asp Lys Ser Lys Ser His Pro Ala Ala Leu Thr Thr Glu Lys 
            500                 505                 510         


Tyr Gly Leu Asn Lys Lys Glu Leu Leu Lys Ala Cys Thr Asp Arg Glu 
        515                 520                 525             


Ile Leu Leu Met Lys Arg Asn Ser Phe Val Tyr Phe Phe Lys Leu Phe 
    530                 535                 540                 


Gln Leu Thr Val Met Ala Phe Ile Ser Met Thr Val Phe Phe Arg Thr 
545                 550                 555                 560 


Glu Met His Lys Arg Thr Leu Thr Asp Gly Gly Phe Tyr Thr Ala Ala 
                565                 570                 575     


Ala Phe Phe Gly Val Ile Met Leu Met Phe Asn Gly Met Ser Glu Ile 
            580                 585                 590         


Ser Met Thr Ile Ala Lys Leu Pro Val Phe Tyr Lys Gln Arg Asn Phe 
        595                 600                 605             


Leu Phe Tyr Pro Ser Trp Ala Tyr Ala Ile Pro Ser Trp Ile Met Lys 
    610                 615                 620                 


Ile Pro Val Ser Phe Val Glu Ala Ala Val Trp Thr Ile Leu Thr Tyr 
625                 630                 635                 640 


Tyr Val Met Gly Phe Asp Pro Asn Val Tyr Arg Phe Phe Arg Tyr Phe 
                645                 650                 655     


Phe Ile Leu Met Leu Val Asn Gln Met Ser Ser Gly Leu Phe Arg Phe 
            660                 665                 670         


Ile Gly Ala Leu Gly Arg Asn Met Ile Val Ala Asn Thr Phe Gly Ser 
        675                 680                 685             


Phe Ala Leu Leu Leu Val Phe Ala Leu Gly Gly Phe Ile Leu Ser Arg 
    690                 695                 700                 


Asp Asp Ile Lys Gly Trp Trp Ile Trp Gly Tyr Trp Ala Ser Pro Leu 
705                 710                 715                 720 


Met Tyr Ala Met Asn Gly Ile Val Val Asn Glu Phe Arg Gly His Ser 
                725                 730                 735     


Trp Arg Thr Pro Leu Asn Gly Ser Thr Leu Gly Ile Gln Thr Ile Thr 
            740                 745                 750         


Gly Arg Gly Phe Phe Ala Glu Ala Tyr Trp Tyr Trp Ile Ala Ala Ala 
        755                 760                 765             


Ala Leu Phe Gly Phe Ile Ile Val Leu Asn Ile Cys Tyr Ala Leu Ser 
    770                 775                 780                 


Leu Ser Leu Leu Asp Ala Phe Gly Lys Lys Lys Ala Asp Ile Ser Ser 
785                 790                 795                 800 


Leu Asp Glu Ser Asp Ala Ala Val Glu Leu Ser Ser Met Asn Lys Glu 
                805                 810                 815     


Asp Glu Gly Ser Gln Asn Lys Lys Lys Gly Met Ile Leu Pro Phe Glu 
            820                 825                 830         


Pro His Ser Ile Thr Phe Asp Asp Val Lys Tyr Ser Val Asp Met Pro 
        835                 840                 845             


Gln Glu Met Lys Glu Gln Gly Val Ser Glu Asp Arg Leu Leu Leu Leu 
    850                 855                 860                 


Lys Gly Val Ser Gly Ala Phe Arg Pro Gly Val Leu Thr Ala Leu Met 
865                 870                 875                 880 


Gly Val Ser Gly Ala Gly Lys Thr Thr Leu Met Asp Val Leu Ala Gly 
                885                 890                 895     


Arg Lys Thr Gly Gly Tyr Ile Glu Gly Asp Ile Lys Val Ser Gly Tyr 
            900                 905                 910         


Pro Lys Lys Gln Glu Thr Phe Ala Arg Ile Ser Gly Tyr Cys Glu Gln 
        915                 920                 925             


Asn Asp Ile His Ser Pro His Val Thr Val Tyr Glu Ser Leu Ile Tyr 
    930                 935                 940                 


Ser Ala Trp Leu Arg Leu Ala Ser Asp Val Asp Glu Asn Gln Arg Lys 
945                 950                 955                 960 


Ala Phe Val Asp Gln Val Ile Asp Leu Val Glu Leu Asn Ser Leu Lys 
                965                 970                 975     


Asp Ser Leu Val Gly Leu Pro Gly Val Asn Gly Leu Ser Thr Glu Gln 
            980                 985                 990         


Arg Lys Arg Leu Thr Ile Ala Val  Glu Leu Val Ala Asn  Pro Ala Ile 
        995                 1000                 1005             


Ile Phe  Met Asp Glu Pro Thr  Ser Gly Leu Asp Ala  Arg Ala Ala 
    1010                 1015                 1020             


Ala Ile  Val Met Arg Thr Val  Arg Asn Thr Val Asp  Thr Gly Arg 
    1025                 1030                 1035             


Thr Val  Val Cys Thr Ile His  Gln Pro Ser Ile Asp  Ile Phe Glu 
    1040                 1045                 1050             


Ala Phe  Asp Glu Leu Phe Leu  Met Lys Arg Gly Gly  Gln Glu Leu 
    1055                 1060                 1065             


Tyr Ala  Gly Pro Ile Gly Arg  Asn Ser Cys Glu Leu  Ile Glu Tyr 
    1070                 1075                 1080             


Phe Glu  Ala Ile Asn Gly Val  Ser Lys Ile Thr Asp  Gly Tyr Asn 
    1085                 1090                 1095             


Pro Ala  Thr Trp Met Leu Glu  Val Ser Thr Ser Ala  Gln Glu Ala 
    1100                 1105                 1110             


Ala Leu  Gly Val Asp Phe Thr  Ser Ile Tyr Arg Asn  Ser Glu Leu 
    1115                 1120                 1125             


Tyr Lys  Arg Asn Lys Ala Leu  Ile Ala Glu Leu Ser  Val Pro Arg 
    1130                 1135                 1140             


Pro Gly  Thr Lys Asp Leu Phe  Phe Pro Thr Gln Tyr  Ser Gln Ser 
    1145                 1150                 1155             


Phe Leu  Val Gln Cys Ile Ala  Cys Leu Trp Lys Gln  Arg Trp Ser 
    1160                 1165                 1170             


Tyr Trp  Arg Asn Pro Pro Tyr  Thr Ala Val Arg Phe  Val Phe Thr 
    1175                 1180                 1185             


Thr Phe  Ile Gly Ile Ile Phe  Gly Thr Met Phe Trp  Asp Ile Gly 
    1190                 1195                 1200             


Gly Lys  Arg Asn Thr Gln Gln  Asn Leu Thr Asn Ser  Ile Gly Ser 
    1205                 1210                 1215             


Met Tyr  Gly Ala Val Leu Phe  Leu Gly Ile Gln Asn  Ala Ser Ala 
    1220                 1225                 1230             


Val Gln  Pro Val Val Asp Ile  Glu Arg Thr Val Phe  Tyr Arg Glu 
    1235                 1240                 1245             


Arg Ala  Ala Gly Met Tyr Ser  Ala Leu Pro Tyr Ala  Phe Ala Gln 
    1250                 1255                 1260             


Val Leu  Val Glu Ile Pro Tyr  Val Phe Ala Gln Ala  Val Val Tyr 
    1265                 1270                 1275             


Ser Leu  Ile Val Tyr Ala Met  Ile Gly Phe Glu Trp  Thr Ala Ala 
    1280                 1285                 1290             


Lys Phe  Phe Trp Tyr Leu Phe  Phe Gln Phe Cys Cys  Phe Leu Tyr 
    1295                 1300                 1305             


Met Thr  Tyr Tyr Gly Met Met  Thr Val Ala Ile Thr  Pro Asn Ala 
    1310                 1315                 1320             


Ser Ile  Ala Ala Ile Ile Ala  Ala Ser Phe Tyr Gly  Ile Phe Asn 
    1325                 1330                 1335             


Leu Phe  Ser Gly Tyr Ile Ile  Pro Arg Pro Ser Ile  Pro Val Trp 
    1340                 1345                 1350             


Trp Arg  Trp Tyr Tyr Trp Gly  Asn Pro Leu Ala Trp  Thr Ile Tyr 
    1355                 1360                 1365             


Gly Met  Ile Val Ser Gln Phe  Gly Asp Tyr Thr Asn  Glu Phe Pro 
    1370                 1375                 1380             


Asn Gly  Gln Thr Val Lys Glu  Tyr Leu Asp Asp Tyr  Leu Ala Ile 
    1385                 1390                 1395             


Glu Ala  Thr Ser Ala Leu Glu  Glu Tyr Gly Cys Phe  Ile Ala Glu 
    1400                 1405                 1410             


Phe Asp  Lys Val Thr Pro Glu  Leu Asn Asp Ala Val  Phe Leu Glu 
    1415                 1420                 1425             


Asp Leu  Phe Asp Ile Pro Ile  Glu Thr Lys Val Leu  Asn Met Ser 
    1430                 1435                 1440             


Thr Lys  Pro Leu Tyr Gly Tyr  Val Ala Asn Val Gly  Gln Ile Pro 
    1445                 1450                 1455             


Phe Ile  Pro Leu Tyr Glu Ser  Met Gly Phe Asp Tyr  Ser Asn Thr 
    1460                 1465                 1470             


Leu Asp  Gly Val Arg Ser Phe  Thr Glu Val Met Trp  Pro Asn Gly 
    1475                 1480                 1485             


Asn Glu  Ala Phe Arg 
    1490             


<210>  229
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  229

Met Arg Arg Leu Pro Leu Thr Tyr Phe Ile Tyr Gln Lys Gln Asn Ile 
1               5                   10                  15      


Phe Ser Leu Leu Phe Gly Tyr Phe Val Leu Pro His Ile Asp Phe Asn 
            20                  25                  30          


Phe Phe Ile Ala Leu Asp Trp Met Lys Gly Ser Ser Pro Thr Leu Leu 
        35                  40                  45              


Ile Gly Val Leu Thr Ser Val Leu Pro Thr Asp Ala Phe Val Thr Gly 
    50                  55                  60                  


Val Gly His Gln Tyr Arg Val Tyr Asp Leu Arg Leu Leu Leu Ala Cys 
65                  70                  75                  80  


Val Cys Ser Cys Phe Asp Ser His Leu Glu Phe Cys Tyr Asn Leu Gly 
                85                  90                  95      


Cys Thr Tyr Ser Phe Cys Val Gln Tyr Pro Gln Gly Val Asp Val Ser 
            100                 105                 110         


Lys Gly Pro Lys Trp Glu Pro Val Pro Glu Met Cys Ser Thr Pro Asp 
        115                 120                 125             


Ile Thr Leu Gly Ile Thr Ser His Thr Asp Pro Asn Val Leu Thr Val 
    130                 135                 140                 


Leu Ile Gln Asn Glu Ile Gly Gly Gln Leu Gln Ala Lys Cys Gly Glu 
145                 150                 155                 160 


Asp Trp Val Val Val Glu Arg Phe Leu Val His Arg Glu Glu Met Asn 
                165                 170                 175     


Ser Gly Val Trp Arg Trp Asp Trp Glu Asn Gly Tyr Tyr Gly Ser Leu 
            180                 185                 190         


Ile Ser Tyr Ser Tyr Ile Asn Glu Asn Thr Leu Phe Lys Met Asp Ser 
        195                 200                 205             


Ala Asn Asp Met Glu Val Thr Ser Gln Asp Asp Asp Thr Ser Ala Tyr 
    210                 215                 220                 


Asn Ser Pro Tyr Lys Ser Thr Ile Ser Ala Ile Phe Leu Ser Cys Ala 
225                 230                 235                 240 


Thr Thr Ala Thr Ile Leu Ala Gln Lys Leu Phe Thr Phe Leu Ala Thr 
                245                 250                 255     


Ser Ala Ala Thr Val Ser Leu Met Ile Leu Lys Gly Leu Asp Gln Pro 
            260                 265                 270         


Ile Val Leu Lys Thr Ser Pro Ala Trp Val Leu Phe Leu Lys Val Ala 
        275                 280                 285             


Gly Gly Arg Val Ser Tyr Gln Thr Ala Ser Ile Arg Thr Thr Leu Asp 
    290                 295                 300                 


Asn Met Val Gln Leu Pro Asn Asp Cys 
305                 310             


<210>  230
<211>  999
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  230

Met Ala Glu Ala Ile Val Ser Ser Thr Val Gly Lys Val Ala Asp Leu 
1               5                   10                  15      


Leu Phe Gly Lys Val Ile Lys Glu Ile Asn His Ile Arg Asn Cys Thr 
            20                  25                  30          


Glu Asn Val Glu Lys Phe Lys Thr Glu Val Glu Met Leu Lys Val Met 
        35                  40                  45              


Arg Gly Lys Val Gln Gln Gln Ile Glu Ile Ala Asn Ser Lys Gly Asp 
    50                  55                  60                  


Asn Leu Ile Thr Gly Val Glu Asp Trp Val Glu Lys Ala Asp Thr Glu 
65                  70                  75                  80  


Ile Ser Lys Ala Glu Ala Phe Leu Asn Glu Glu Ala Asn Ala Lys Lys 
                85                  90                  95      


Thr Cys Phe Lys Ile Gly Leu Cys Gly Asn Trp His Thr Leu Tyr His 
            100                 105                 110         


Tyr Gly Lys Thr Ala Thr Lys Met Ser Pro Tyr Leu Leu Gln His Gln 
        115                 120                 125             


Glu Val Gly Lys Gly Tyr Glu Thr Cys Val Ser Val Tyr Thr Pro Ala 
    130                 135                 140                 


Pro Gly Pro Leu Glu Val Tyr Gln Asn Lys Asn Leu Asp Asp Ile Ala 
145                 150                 155                 160 


Thr Gln Asn Ser Ala Leu Gly Asp Ile Ile Thr Ala Ile Glu Asp Glu 
                165                 170                 175     


Asp Lys Ser Lys Gln Ile Ile Gly Ile Tyr Gly Ile Gly Gly Val Gly 
            180                 185                 190         


Lys Thr Thr Leu Ala Met Glu Val Ser Ala Arg Val Lys His Val Phe 
        195                 200                 205             


Ala Ala Val Ala Phe Thr Thr Val Ser Gln Thr Val Ser Val Glu Lys 
    210                 215                 220                 


Ile Lys Asn Asp Ile Gly Asp Ala Thr Lys Arg Ile Met Lys Gly Glu 
225                 230                 235                 240 


Lys Ile Leu Ile Ile Leu Asp Asp Val Trp Glu Lys Val Glu Leu Glu 
                245                 250                 255     


Lys Leu Cys Ile Pro Cys Gly Ile Asn His Met Asn Cys Lys Ile Leu 
            260                 265                 270         


Leu Thr Ser Arg Ser Glu Tyr Val Cys Glu Lys Met Asn Ala His Lys 
        275                 280                 285             


Ile Cys Val Asn Ala Leu Pro Glu Lys Glu Ala Trp Ile Leu Phe Lys 
    290                 295                 300                 


Arg Val Val Gly Glu Glu Val Glu Arg Glu Thr Asp Leu Lys Gln Val 
305                 310                 315                 320 


Ala Met Lys Val Ala Glu Glu Cys Gly Gly Leu Pro Leu Phe Leu Asn 
                325                 330                 335     


Ala Val Gly Asn Ala Leu Lys Asn Lys Ser Ile Glu Asp Trp Asp Lys 
            340                 345                 350         


Ala Leu Thr Arg Leu Gln Glu His Ala Pro Thr Arg Val Asp Pro Glu 
        355                 360                 365             


Ile Gly Lys Ala Phe Thr Arg Leu Lys Leu Ser Tyr Asp Phe Leu Asp 
    370                 375                 380                 


Asn Asn Glu Ala Arg Leu Cys Phe Leu Leu Cys Ser Met Phe Glu Glu 
385                 390                 395                 400 


Asp Lys Glu Ile Trp Leu Glu Asp Leu Val Gln Tyr Ala Val Gly Leu 
                405                 410                 415     


Ala Lys Phe His Gly Leu Lys Ser Met Asp Asp Ala Arg Gln Arg Val 
            420                 425                 430         


Glu Asp Ala Val Lys Ile Leu Thr Ser Ser Gly Leu Leu Leu Lys Leu 
        435                 440                 445             


Asp Asp Lys Glu Tyr Thr Lys Met His Asp Val Val Arg Asp Val Ala 
    450                 455                 460                 


Leu Leu Ile Ala Ser Glu Gly Asp Gly Lys Ser Lys Phe Leu Val Glu 
465                 470                 475                 480 


Ala Gly Lys Gly Phe Thr Glu Trp Leu Pro Arg Lys Asn Glu Leu Glu 
                485                 490                 495     


Ser Tyr Thr Gly Ile Ser Leu Met Lys Asn Asn Ile Ser Lys Leu Pro 
            500                 505                 510         


Asn Tyr Glu Leu His Leu Pro His Leu Asp Ile Phe Leu Ile Ser Val 
        515                 520                 525             


Asn Asp Lys Leu Pro Met Phe Ser Asp Glu Leu Ile Arg Gly Met Lys 
    530                 535                 540                 


Glu Val Arg Val Leu Asp Met Ser Trp Cys Glu Val Gln Pro Leu Pro 
545                 550                 555                 560 


Gln Ser Phe Lys Phe Leu Thr Lys Leu Arg Met Leu Asp Leu Gln Gly 
                565                 570                 575     


Asn Lys Ser Leu His Asp Ile Ser Ile Leu Gly Glu Met Gln Asp Leu 
            580                 585                 590         


Glu Ile Leu Ile Leu Asn Phe Thr Gly Ile Lys Glu Ile Pro Gln Glu 
        595                 600                 605             


Ile Gly Leu Leu Val Asn Leu Arg Arg Leu Glu Ala Ile Gly Cys Glu 
    610                 615                 620                 


Asn Leu Tyr His Val Ala Pro Gly Val Ile Ser Lys Leu Trp Arg Leu 
625                 630                 635                 640 


Glu Glu Leu Leu Ile Gly Phe Met Trp Met Leu Glu Gly Ile Cys Glu 
                645                 650                 655     


Arg Ile Val Glu Ile Met Asn Leu Ser Asn Leu Thr Tyr Leu Ala Leu 
            660                 665                 670         


His Val Pro Arg Phe Gly Met Ile Pro Glu Gly Phe Asn Pro Gln Lys 
        675                 680                 685             


Leu Lys Gly Phe Val Ile Gln Ile Gly Gly Tyr Phe Glu Tyr Tyr Ser 
    690                 695                 700                 


Ala Ala Asn Leu Lys Arg Arg His Leu Val Ile Gln Thr Asp Tyr Ala 
705                 710                 715                 720 


Glu Ser Ser Phe Leu Lys Trp Asn Lys Gln Leu Ile Glu Ala Cys Asp 
                725                 730                 735     


Thr Thr Asp Leu Asp Ser Ile Gln Asn Leu Asn Asn Ile Leu Pro Gln 
            740                 745                 750         


Leu Tyr His Glu Gly Phe Asn Glu Leu Glu His Ile Asn Leu Tyr Lys 
        755                 760                 765             


Cys Arg Tyr Val Ser Cys Leu Ile Asp Thr Ala Asn Trp Asp Gln Leu 
    770                 775                 780                 


His Thr Phe Asn Leu Pro Lys His Ile Val Glu Gly Lys Ile Lys Glu 
785                 790                 795                 800 


Met Phe Leu Gly Lys Leu Lys His Leu Arg Leu Val Arg Leu Gln Asn 
                805                 810                 815     


Leu Val Val Leu Trp Lys Cys Pro Asp Glu Tyr Ile Ser Leu Ser Asn 
            820                 825                 830         


Leu Val Thr Leu Glu Ile Ile Glu Cys Asp Glu Leu Val Lys Val Phe 
        835                 840                 845             


Pro Val Ser Val Ala Gln Gly Leu Val Asn Leu Gln Asn Leu Thr Val 
    850                 855                 860                 


Ala Met Cys Gly Ser Leu Glu Glu Val Ile Trp Asp Gly Asp Glu Glu 
865                 870                 875                 880 


Thr Ser Lys Ser Glu Thr Glu His Ser Glu Tyr Thr Val Phe Arg Ser 
                885                 890                 895     


Leu Ala Lys Ile Asn Leu Tyr Glu Leu Glu Arg Leu Glu Arg Phe Tyr 
            900                 905                 910         


Ser Gly His Ser Thr Ile Lys Tyr Pro Ser Leu Val Asp Ala Asp Ile 
        915                 920                 925             


Glu Tyr Cys Pro Ser Met Lys Met Trp Gly Pro Gly Ile His Glu Thr 
    930                 935                 940                 


Pro Lys Leu Lys Phe Val Tyr Pro Tyr Val Gln Leu Asp Gly Pro Asp 
945                 950                 955                 960 


Ala Thr Ile Asn Tyr Ala Val Asn Lys Leu Leu Glu Thr Glu Lys His 
                965                 970                 975     


Arg Trp Glu Leu Arg Phe Ala Lys Arg Val Leu Arg Gln His Arg Arg 
            980                 985                 990         


Lys Gln Lys Met Lys Ile Gln 
        995                 


<210>  231
<211>  1011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  231

Met Gly Asp Val Ala Ala Lys Glu Leu Phe Gly Arg Val Phe Asn Ser 
1               5                   10                  15      


Leu Val Gly Phe Ala Ile Lys Glu Ile Asn Tyr Met Arg Lys Cys Ser 
            20                  25                  30          


Glu Asn Val Glu Lys Asn Arg Asp Glu Leu Arg Asn Leu Lys Ala Met 
        35                  40                  45              


Arg Gly Lys Val Gln Gln Gln Ile Asp Ile Ala Ile Arg Lys Gly Asp 
    50                  55                  60                  


Asn Leu Ile Ile Gly Val Glu Glu Trp Val Lys Lys Val Asp Val Glu 
65                  70                  75                  80  


Ile Ser Lys Ala Glu Glu Phe Leu Glu Gln Glu Ala Asn Ala Lys Lys 
                85                  90                  95      


Thr Cys Phe Lys Ile Gly Leu Cys Gly Asn Trp His Thr Leu Tyr His 
            100                 105                 110         


Tyr Gly Lys Met Ala Thr Lys Met Ser Pro Tyr Leu Leu Arg His Gln 
        115                 120                 125             


Glu Gly Gly Lys Gly Tyr Glu Thr Cys Val Ser Met Ala Thr Lys Met 
    130                 135                 140                 


Ser Pro Tyr Leu Leu Arg His Gln Glu Gly Gly Lys Gly Tyr Glu Thr 
145                 150                 155                 160 


Cys Val Ser Val Tyr Thr Pro Ala Pro Gly Pro Leu Glu Val Tyr Gln 
                165                 170                 175     


Asn Lys Asn Leu Asp Asp Ile Ala Thr Gln Asn Ser Ala Leu Gly Asp 
            180                 185                 190         


Ile Ile Thr Ala Ile Glu Asp Glu Asp Val Ser Lys Gln Ile Ile Gly 
        195                 200                 205             


Ile Tyr Gly Leu Gly Gly Val Gly Lys Thr Thr Leu Ala Met Glu Val 
    210                 215                 220                 


Ser Ala Arg Val Lys His Leu Phe Ala Ala Val Ala Phe Thr Thr Val 
225                 230                 235                 240 


Ser Gln Thr Val Ser Ile Glu Lys Ile Gln Asn Asp Ile Gly Asp Ala 
                245                 250                 255     


Thr Lys Arg Ile Met Lys Gly Glu Lys Ile Leu Ile Ile Leu Asp Asp 
            260                 265                 270         


Val Trp Glu Lys Val Asp Leu Glu Asn Leu Cys Ile Pro Cys Gly Ile 
        275                 280                 285             


Asn His Pro Asn Cys Lys Ile Leu Leu Thr Ser Arg Ser Glu Ser Val 
    290                 295                 300                 


Cys Glu Lys Met Asn Ala His Lys Ile Cys Val Asn Ala Leu Pro Lys 
305                 310                 315                 320 


Lys Glu Ala Trp Ile Leu Phe Lys Arg Val Val Gly Val Arg Val Glu 
                325                 330                 335     


Thr Asp Ala Asp Leu Lys Arg Val Ala Pro Lys Val Val Glu Glu Cys 
            340                 345                 350         


Gly Gly Leu Pro Leu Phe Leu Lys Thr Val Gly Asn Ala Leu Lys His 
        355                 360                 365             


Lys Ser Ile Glu Asp Trp Glu Lys Ala Leu Thr Arg Leu Gln Glu His 
    370                 375                 380                 


Ala Pro Thr Arg Val Asp Pro Glu Ile Gly Lys Ala Phe Thr Arg Leu 
385                 390                 395                 400 


Lys Leu Ser Tyr Asp Phe Leu Asp Asn Glu Ala Arg Leu Cys Phe Leu 
                405                 410                 415     


Leu Cys Ser Met Phe Glu Glu Asp Arg Glu Ile Trp Leu Glu Asp Leu 
            420                 425                 430         


Val Asn Tyr Ala Val Gly Leu Ala Lys Phe His Gly Leu Lys Ser Ile 
        435                 440                 445             


Glu Asp Ala Arg Gln Arg Val Glu Asp Ala Val Asn Ile Leu Thr Ser 
    450                 455                 460                 


Ser Gly Leu Leu Leu Asn Leu Asp Asp Lys Arg Arg Thr Lys Met His 
465                 470                 475                 480 


Asp Val Val Arg Asp Val Ala Leu Leu Ile Ala Ser Glu Gly Asp Gly 
                485                 490                 495     


Lys Asn Asn Phe Leu Val Glu Ala Gly Lys Gly Leu Thr Glu Trp Leu 
            500                 505                 510         


Pro Arg Lys Asn Glu Leu Glu Ser Tyr Thr Gly Ile Ser Leu Cys Lys 
        515                 520                 525             


Asn Lys Ile Ser Lys Leu Pro Asn His Glu Leu Tyr Leu Pro His Leu 
    530                 535                 540                 


Asp Ile Phe Leu Ile Gln Arg Asn Asp Glu Leu Pro Lys Phe Ser Asp 
545                 550                 555                 560 


Glu Leu Ile Arg Gly Ile Lys Glu Val Arg Val Leu Asp Met Ser Trp 
                565                 570                 575     


Cys Lys Ile Gln Pro Leu Pro Gln Ser Phe Lys Phe Leu Thr Lys Leu 
            580                 585                 590         


Arg Met Leu Asp Leu Gln Gly Asn Lys Ser Leu His Asp Ile Ser Ile 
        595                 600                 605             


Leu Val Glu Met Gln Asp Leu Glu Ile Leu Ile Leu Asp Lys Thr Gly 
    610                 615                 620                 


Ile Lys Glu Ile Pro Gln Glu Ile Gly Gln Leu Val Asn Leu Arg Arg 
625                 630                 635                 640 


Leu Arg Ala Leu Asn Cys Ser Asn Leu Ser His Val Ala Pro Gly Val 
                645                 650                 655     


Ile Ser Gln Leu Trp Arg Leu Glu Glu Leu Leu Ile Gly Phe Met Trp 
            660                 665                 670         


Glu Leu Glu Gly Ile Tyr Glu Arg Ile Val Glu Ile Met Asn Leu Ser 
        675                 680                 685             


Asn Leu Thr Tyr Leu Ala Leu His Val Pro Arg Phe Asp Val Ile Pro 
    690                 695                 700                 


Glu Gly Phe Asn Leu Arg Lys Leu Lys Gly Phe Phe Ile Gln Ile Gly 
705                 710                 715                 720 


Gly Ser Leu Glu Phe Phe Tyr Pro Leu Ala Asn Leu Lys Ser Gln His 
                725                 730                 735     


Leu Val Ile Lys Thr Asp Tyr Val Glu Ile Pro Phe Leu Lys Ser Leu 
            740                 745                 750         


Lys Gln Leu Ile Glu Ala Ser His Ser Thr Asp Leu Tyr Cys Ile Glu 
        755                 760                 765             


Asn Leu Asn Asn Ile Leu Pro Gln Leu Tyr His Glu Gly Phe Asn Glu 
    770                 775                 780                 


Leu Glu His Ile Lys Leu Asn Asn Cys Pro Asn Val Ser Cys Leu Val 
785                 790                 795                 800 


Asp Thr Thr Asn Trp Asp Gln Phe His Ser Ser Lys His Leu Gly Glu 
                805                 810                 815     


Gly Lys Ile Lys Asp Lys Phe Phe Gly Lys Leu Lys His Leu His Leu 
            820                 825                 830         


Ala Tyr Leu Pro Ser Leu Glu Val Leu Trp Asn Cys Pro Asp Gln Tyr 
        835                 840                 845             


Ile Ser Leu Ser Asn Leu Val Thr Leu Ser Ile Phe Gln Cys Asp Lys 
    850                 855                 860                 


Leu Val Lys Val Phe Pro Val Ser Val Ala Gln Gly Leu Val Asn Leu 
865                 870                 875                 880 


Gln Asn Leu His Ile Ser Leu Cys Asn Ser Leu Glu Lys Val Ile Trp 
                885                 890                 895     


Asp Gly Asp Glu Glu Thr Ser Lys Ser Glu Thr Glu His Ser Glu Tyr 
            900                 905                 910         


Ile Val Phe Arg Ser Leu Ala Lys Ile Asp Phe Phe Ile Leu Glu Arg 
        915                 920                 925             


Leu Glu Arg Phe Tyr Ser Gly His Ser Thr Ile Lys Tyr Pro Ala Leu 
    930                 935                 940                 


Val Glu Val Asn Ile Tyr Ser Cys Pro Ser Met Lys Met Trp Gly Pro 
945                 950                 955                 960 


Gly Ile His Glu Thr Pro Lys Leu Lys Phe Val Lys Asn Val Gln Leu 
                965                 970                 975     


Asp Gly Pro Asp Ala Thr Ile Asn Tyr Ala Val Asn Lys Ile Tyr Glu 
            980                 985                 990         


Ala Glu Lys Lys Leu Trp Asn Glu  Leu Met Met Met Glu  Pro Arg Ile 
        995                 1000                 1005             


Arg Cys  Glu 
    1010     


<210>  232
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  232

Met Ala Leu Ser Phe Asn Asp Glu Asn Ser Leu Phe Asn Phe Val Val 
1               5                   10                  15      


Lys Asp Gly Asn Gly Val Lys Gly Leu Val Asp Ser Gly Leu Thr Gln 
            20                  25                  30          


Val Pro Gly Gln Tyr Ile Gln Pro Pro Ile His Arg Ile Asn Lys Gln 
        35                  40                  45              


Asn Thr Thr Val Ser Leu Glu Asn Met Ile Ile Asp Leu Ser Glu Leu 
    50                  55                  60                  


Asp Gly Pro Asn His Asp Gln Val Val Lys Ser Ile Ala His Ala Ala 
65                  70                  75                  80  


Glu Thr Pro Gly Phe Phe Gln Val Val Asn His Gly Val Pro Ile Glu 
                85                  90                  95      


Leu Leu Glu Ser Leu Lys Val Ser Ala His Glu Phe Phe Asn Gln Pro 
            100                 105                 110         


Ser Glu Lys Lys Ala Val Tyr Leu Lys Gly Val Ser Pro Ser Pro Met 
        115                 120                 125             


Val Lys Tyr Gly Thr Ser Phe Val Pro Glu Lys Glu Lys Ala Leu Glu 
    130                 135                 140                 


Trp Lys Asp Tyr Ile Ser Met Ile Tyr Thr Asn Asp Ala Asp Ala Leu 
145                 150                 155                 160 


Glu Phe Trp Pro Asn Glu Cys Lys Glu Val Ala Leu Glu Tyr Ile Lys 
                165                 170                 175     


Thr Ser Thr Gly Met Ser Lys Thr Arg Thr Pro Ser Pro Ser Leu Ser 
            180                 185                 190         


Asp Glu Asn Leu Ser Asp Ser Val Ala Ser Val Gly Arg Glu Gly Asn 
        195                 200                 205             


Leu Gly Gln Ser Gly Arg Val Val Asp Asp Val Gln Asp Asp Gln Leu 
    210                 215                 220                 


Glu Gln Ile Leu Tyr Pro Gly Thr Ser Gln Gln Pro Ala Glu Pro Ser 
225                 230                 235                 240 


Ser Ala Thr Pro Leu Asp Glu Asn Val Asn Ser Glu Gly Asn Ala Ile 
                245                 250                 255     


Pro 
    


<210>  233
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  233

Met Ser Asn Ser Leu Asp Phe Arg Ala Pro Pro Pro Ser Pro Val Gly 
1               5                   10                  15      


Pro Gly Arg Arg Ser Thr Val Ala Asn Asp Asp Ile Leu Thr Asp Phe 
            20                  25                  30          


Leu His Gln Thr Leu Ile Val Pro Asp Leu Val Leu Pro Asp Arg Val 
        35                  40                  45              


Phe Pro Arg Gln Asn Pro Asn Ile Gln Ser Leu Pro Lys Leu Asp Phe 
    50                  55                  60                  


Lys Lys Phe Ser Glu Asp Cys Lys Val Asp Glu Val Ile Glu Val Ile 
65                  70                  75                  80  


Ala Gln Thr Gly Cys Phe Glu Leu Val Asn His Gly Ile Ser Ser Lys 
                85                  90                  95      


Leu Leu Arg Asp Val Lys Glu Cys Gly Lys Gly Val Phe Gly Leu Glu 
            100                 105                 110         


Asp Glu Lys Lys Arg Val Val Leu Arg Ser Asn Glu Arg Leu Tyr Gly 
        115                 120                 125             


Phe Val Asp Val Asn Gly Asp Asp Lys Asp Val Ser Glu Glu Phe Val 
    130                 135                 140                 


Trp Cys Arg Asp Glu Ser Leu Arg Ser Glu Met Glu Gly Val Trp Thr 
145                 150                 155                 160 


Asn Tyr Thr Asp Phe Ser Glu Lys Met Glu Ser Leu Met Ser Lys Ile 
                165                 170                 175     


Glu Asn Ile Ser Glu Ser Leu Leu Lys Leu Phe Leu Asp Pro Ser Thr 
            180                 185                 190         


Pro Lys Ser Arg Leu Pro Asp Asp Ser Asn Gly Asp Lys Glu Thr Met 
        195                 200                 205             


Gly Ser Met Cys Tyr Leu Tyr Lys His Ser Lys Asn Met Asp Asn Leu 
    210                 215                 220                 


Ser Asn Asp Asp Glu Tyr Met Asp Ser Leu Ser Tyr Asp Val Ile Arg 
225                 230                 235                 240 


Met Leu Ile Arg Gly Ser Glu His Lys His Thr Leu Cys Phe His Val 
                245                 250                 255     


Cys Asp Gly Ser Ser Glu Phe His Val Tyr Ser Lys Lys Gly Trp Val 
            260                 265                 270         


Ser Phe Ser Pro Asp Lys Asn Ala Leu Val Gly Thr Ile Gly Asp Gln 
        275                 280                 285             


Leu Gln Thr Trp Ser Glu Gly Lys Tyr Lys His Val Ile Gly Arg Pro 
    290                 295                 300                 


Ile Phe Lys Gly Glu Leu Ala Asp Cys Ile Ser Met Ala Phe Leu Tyr 
305                 310                 315                 320 


Ser Pro Pro Ile Ser Arg Gly Gln Glu Asp Asn Thr Ile Ser Leu Asp 
                325                 330                 335     


His Arg Gly Phe Ile Gly Pro Met Thr Pro Pro Ala Thr Asp Lys Gly 
            340                 345                 350         


Lys Asn Lys Met Tyr Gln Tyr Thr Asp Lys Asp Leu Ile Ser Asp Glu 
        355                 360                 365             


Leu Leu Cys Glu Ile Glu Asn Asn Asp Ile Ser Leu Leu Asn Glu Gln 
    370                 375                 380                 


Tyr Gly Cys Ser Tyr Phe Ala Pro Ser Ser Leu Ser Pro Ile Arg Gly 
385                 390                 395                 400 


Gln Thr Asn Glu Ala Phe Asn Ile Tyr Pro Thr Ile Arg Gln Asp Asn 
                405                 410                 415     


Ala Arg Val Ser Ser Val Ala Pro Thr Leu Ala Glu Gly Gln Gly Ser 
            420                 425                 430         


Ser Ser Ser Met Pro Glu Trp Pro Phe Pro Ser Thr Pro Ser Val Ala 
        435                 440                 445             


Pro Arg Ser Ser Ser Arg Ala Gly Ala Gly Met Pro Ser Gln Val Arg 
    450                 455                 460                 


Gln Gly Leu Met Leu Ser Ser Leu Leu Thr Gln Cys Leu Lys Leu Thr 
465                 470                 475                 480 


Gly Asp Thr Val Gln Lys Gln Asp Pro Ile Glu Gln Gly Val Ser Gly 
                485                 490                 495     


Lys Val Leu Gln Gln His Thr Cys Ile Trp Thr Ser Ala Ile Lys Tyr 
            500                 505                 510         


Ala Val Thr Ala Thr Leu Phe Ser Gly Ser Met Asn Ala 
        515                 520                 525 


<210>  234
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  234

Met Phe Leu Lys Arg Arg Ala Met Glu Gln Asn Ala Ala Ala Ala Ala 
1               5                   10                  15      


Asp Asn Glu Leu Val Ser Ala Val Glu Phe Trp Lys Ala Leu Leu Glu 
            20                  25                  30          


Gln Glu Asp Glu Pro Phe Tyr Pro Tyr Arg Tyr Arg Tyr Arg Asp Arg 
        35                  40                  45              


Pro Phe Leu Ser Val Arg Ser His Arg Asp Leu Gln Val Ala His Ala 
    50                  55                  60                  


Lys Phe Asp Asn Ile Leu Thr Lys Lys Met Gln Gln Leu Gly Cys Ser 
65                  70                  75                  80  


Arg Pro Asp Ala Ile Ala Phe Ile Glu Ser Thr Leu Pro Lys Pro Lys 
                85                  90                  95      


Ser Tyr Lys Pro Ile Tyr Pro Ala Asp Ser Phe Asn Phe Phe Pro Pro 
            100                 105                 110         


Asn Arg Tyr Arg Asp Phe Asp Val Ala Asp Glu Met Ile Arg Ser Lys 
        115                 120                 125             


His Glu Leu Ala Leu Glu Ser Ile Tyr Asp Leu Phe Asp Asp Leu Thr 
    130                 135                 140                 


Thr Asn Val Glu Ile Leu Tyr Lys Ala Asp Ile Glu Lys Glu Ala Arg 
145                 150                 155                 160 


Lys Leu Arg Ser Leu Arg Leu Arg Arg Phe Tyr Tyr Thr Phe Ile Pro 
                165                 170                 175     


Asp Glu Asp Tyr Leu Glu Asn Ala Phe Arg Arg Glu Gln Ile Gly Ala 
            180                 185                 190         


Ser Val Arg Val Asn Phe Tyr Pro Lys Cys Pro Gln Pro His Leu Lys 
        195                 200                 205             


Leu Arg Ile Ser Pro Cys Tyr Pro Gly Gly Ile Thr Ile Leu Val Asp 
    210                 215                 220                 


Asp Val Glu Ser Cys Gln Ser Asp Leu Pro Gln Gly Tyr Gly Asp Ile 
225                 230                 235                 240 


Val Ala Ser Asp Val Gly Cys His Gly Arg Asp His Val His Pro Glu 
                245                 250                 255     


Tyr Asn 
        


<210>  235
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  235

Met Ser Asn Ser Leu Asp Phe Arg Ala Pro Pro Pro Ser Pro Val Gly 
1               5                   10                  15      


Pro Gly Arg Arg Ser Thr Val Ala Asn Asp Asp Ile Leu Thr Asp Phe 
            20                  25                  30          


Leu His Gln Thr Leu Ile Val Pro Asp Leu Val Leu Pro Asp Arg Val 
        35                  40                  45              


Phe Pro Arg Gln Asn Pro Asn Ile Gln Ser Leu Pro Lys Leu Asp Phe 
    50                  55                  60                  


Glu Lys Leu Asn Tyr Ser Glu Asp Phe Lys Leu Glu Asp Val Ile Glu 
65                  70                  75                  80  


Val Ile Ala Gln Thr Gly Cys Phe Glu Leu Val Asn His Gly Ile Ser 
                85                  90                  95      


Ser Asn Leu Leu Trp Asp Val Lys Glu Cys Gly Lys Gly Val Phe Arg 
            100                 105                 110         


Leu Glu Asp Glu Lys Lys Gln Val Val Leu Arg Ser Asn Glu Arg Leu 
        115                 120                 125             


Tyr Gly Phe Val Glu Val Asn Gly Asp Asp Lys Asp Val Ser Glu Glu 
    130                 135                 140                 


Phe Val Trp Cys Arg Asp Glu Ser Leu Arg Ser Glu Met Glu Gly Phe 
145                 150                 155                 160 


Trp Thr Asn Tyr Thr Asn Phe Ser Glu Lys Val Glu Asn Leu Met Ser 
                165                 170                 175     


Lys Ile Glu Asn Ile Ser Glu Ser Leu Leu Lys Leu Phe Leu Asp Pro 
            180                 185                 190         


Ser Thr Pro Lys Ser Arg Phe Gln Asp Asp Ser Thr Ala Asp Lys Glu 
        195                 200                 205             


Thr Met Gly Ser Met Cys Tyr Leu Tyr Lys His Ser Lys Asn Thr Asp 
    210                 215                 220                 


Asn Leu Ser Asn Asp Asp Glu Tyr Val Tyr Glu Phe His Val Tyr Ser 
225                 230                 235                 240 


Lys Lys Gly Trp Val Ser Phe Ser Pro Asp Arg His Ala Leu Val Val 
                245                 250                 255     


Thr Ile Ala Asp Gln Leu Gln Val Asn Ser Gln His Leu Cys Tyr Leu 
            260                 265                 270         


Leu 
    


<210>  236
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  236

Met Glu Pro Ile Asn Glu Phe His Ile Ser Ser Ile Phe Ile Ser Ser 
1               5                   10                  15      


Ser Ser Ile Asp Tyr Asp Ile Tyr Asp Asp Pro Thr Leu Glu Asn Glu 
            20                  25                  30          


Glu Gln Ala Lys Val Lys Asn Glu Ser Gln Glu Gly Lys Arg Lys Glu 
        35                  40                  45              


Lys Leu Leu Asn Glu Leu His Ala Ile Thr Trp Ser Lys Gln Cys Gln 
    50                  55                  60                  


Cys Ser Val Glu Val Val Lys Tyr Leu Arg Asn Leu Val Gly Thr Glu 
65                  70                  75                  80  


Thr Val Glu Leu Glu Ala Lys Asn Met Lys Ile Trp Arg Asn Thr Ile 
                85                  90                  95      


Ala His Gly Cys Glu Glu Trp Leu Tyr Phe Arg Leu Leu Leu Ser His 
            100                 105                 110         


Gly Ala Ser Thr Glu Ala Lys Ala Asn Asn Gly Met Thr Pro Leu His 
        115                 120                 125             


Leu Ser Val Trp His Ser Leu Arg Ala Lys Asp Ser Ser Ile Val Lys 
    130                 135                 140                 


Thr Leu Leu Glu His Asn Ala Asp Cys Val Asp Asp Ser Ser Leu Tyr 
145                 150                 155                 160 


Lys Trp Lys Val Gly Phe Asp Asn Asn Ile Val Ser Pro Asn Leu Val 
                165                 170                 175     


Ser Tyr Asn Tyr Ser Asn Asn Thr Asn Glu Leu Cys Glu Ser Thr Gly 
            180                 185                 190         


Phe Ser Asn Asp Ala Phe Arg Lys Lys Val His Ile Pro Phe Gln Cys 
        195                 200                 205             


Leu Lys Asp Val Ile Val Arg His Arg Met Leu Leu Tyr Phe Ile Lys 
    210                 215                 220                 


Glu Phe Pro Leu Leu Glu Arg Val Ala Ile Ile Asp Ser Leu Arg Leu 
225                 230                 235                 240 


Asn Cys Val Glu Val Pro Val Ser Val Ser Thr Cys Tyr Val Asp Val 
                245                 250                 255     


Leu Asp Leu Gly Arg Ser Gly Cys Val Met Arg Asp Val Thr Phe Val 
            260                 265                 270         


Val Met Glu Met Ser Glu Asp Ile Gly Ser Val Thr Gly Asp Tyr Glu 
        275                 280                 285             


Ser Gly Val 
    290     


<210>  237
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  237

Met Ser Leu Val Lys Arg Arg Arg Glu Gln Gly Ile Cys Gly Gly Asn 
1               5                   10                  15      


Lys Trp Arg Met Val Glu Thr Ser Thr Lys Gln Arg Asn Arg Trp His 
            20                  25                  30          


Ala Asp Cys Pro Lys Thr Glu Ile Asn Gln Glu Ser Ser Asn Pro Thr 
        35                  40                  45              


Ser Asn Leu Thr Ala Trp Met Thr Gln Ser Lys Ile Asp Tyr Lys Glu 
    50                  55                  60                  


Leu Leu Val Asn His Gly Val Asp Lys Leu Leu Val Glu Arg Met Lys 
65                  70                  75                  80  


Lys Glu Met Leu Asp Phe Tyr Asn Leu Pro Val Glu Glu Lys Met Ile 
                85                  90                  95      


Tyr Lys Leu Lys Ala Gly Glu Tyr Glu Gly Tyr Gly Gln Thr Ile Ile 
            100                 105                 110         


His Asp Gln Asp Gln Lys Val Asp Trp Pro Asp Arg Phe Tyr Met Ile 
        115                 120                 125             


Thr Asn Pro Leu His Arg Arg Lys Pro His Leu Leu Pro Lys Leu Pro 
    130                 135                 140                 


Pro Ser Leu Arg Ser Leu Leu Cys Ser Thr Tyr Arg Ile Ile Met Val 
145                 150                 155                 160 


Val Tyr Val Ala Ile Arg Cys Phe Asn Met Asn Leu Gln Ser Arg Val 
                165                 170                 175     


Asn Leu Ile Asp Phe Ala Lys Leu Asn Met Ser Ser Gly Asn Gly Asp 
            180                 185                 190         


Glu Phe Val Val Cys Tyr Met Gln Ser Met Cys Leu Phe Ser Thr Arg 
        195                 200                 205             


Lys Cys Val Gln Gly Gln Gly Val Tyr Leu Ile Glu Val Ala Val Gly 
    210                 215                 220                 


Glu Ile Gly Met Thr Met Lys Ile Thr Pro Leu Gln Glu Ile Thr Pro 
225                 230                 235                 240 


Asp Lys Gly Lys Ala Asn Ile Lys Val Lys Ile Val Ser Leu Trp Asn 
                245                 250                 255     


Gln Tyr Tyr Asn Asn Asn Pro Ser Lys Val Ala Gly Met Asp Met Ile 
            260                 265                 270         


Leu Met Asp Glu Gln Gly Thr Lys Ile His Ala Thr Ile Asn Ser Ser 
        275                 280                 285             


Val Val Cys Asp Phe Asp Ser Leu Leu Lys Glu Asn Asn Tyr His Ile 
    290                 295                 300                 


Ile Ser Asn Phe Asn Val Lys Arg Asn Val Asp Ser Thr Lys Leu Ser 
305                 310                 315                 320 


Lys His Glu Phe Lys Ile His Phe Tyr Arg Lys Thr Asn Val Arg Asn 
                325                 330                 335     


Cys Ser Glu Phe Ile Cys Thr Asp Asp Val Met Glu Phe Ile Ser Phe 
            340                 345                 350         


Lys Asp Phe Leu Asp Ala Arg Ile Asp Gln Ser Tyr Ser Phe Gly Leu 
        355                 360                 365             


Ile Leu Gln Met Leu His Leu Pro Lys Ser Val Lys Ile Lys Ile His 
    370                 375                 380                 


Ile Arg Val Gln Asp Glu Thr Gly Ser Ala Thr Phe Cys Leu Phe Gln 
385                 390                 395                 400 


Gln Glu Val Ala Lys Leu Leu Gly Lys Ser Val Gly Tyr Leu Ile Ser 
                405                 410                 415     


Leu Ile Asp Lys Asp Glu Glu Asn Ile Ser Tyr Pro Ser Asp Leu Glu 
            420                 425                 430         


Ser Ile Val Ser Lys Lys Phe Val Phe Lys Leu Gln Val Ser Ala Tyr 
        435                 440                 445             


Asn Val Asn Asn Asn Tyr His Ile Phe Thr Val Asn Lys Leu Thr Asp 
    450                 455                 460                 


Asp Lys Gly Val Met Asn Leu Ile Gly Thr Lys Asp Thr Glu Glu Glu 
465                 470                 475                 480 


Glu Asn Lys Thr Ala Glu Val Gly Thr Lys Arg Lys Asn Ile Glu Phe 
                485                 490                 495     


Gln Asn Ser Glu Met Glu Lys Lys Pro Lys Val Glu His Gln Asp Thr 
            500                 505                 510         


Glu Asp Asp Thr Val Ile Asn Glu Ile Asp Glu Lys Asp Val Met Lys 
        515                 520                 525             


Ser Ser Leu Ser Lys Gln Thr Glu Glu Gln Gln Cys Lys Thr Thr Ala 
    530                 535                 540                 


Gly Glu Thr Tyr Gly Asp Asn Met Glu Gly 
545                 550                 


<210>  238
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  238

Met Met Met Met Ile Lys Arg Ile Gln Gly Thr Val Lys Pro Leu Ala 
1               5                   10                  15      


Arg Tyr Ala Ser Val Asn Ala Ser Phe Arg Asn Ser Arg Asn Asp Asn 
            20                  25                  30          


Ser His His Asp Lys Tyr Lys Pro Asn His Lys Thr Pro Ala Asn Tyr 
        35                  40                  45              


Asp Leu Asn Gln Thr Lys Pro Phe Ser Leu Ile Leu Pro Arg Ser Thr 
    50                  55                  60                  


Asp Ser Phe Ser Gly Ile Lys Met Pro Glu Asn Leu Glu Arg Ser Cys 
65                  70                  75                  80  


Gln Val Leu Gly Pro Gly Met Val Leu Leu Lys Asn Tyr Ile Asp Ile 
                85                  90                  95      


Ser Asp Gln Val Glu Ile Val Asn Thr Cys Gln Glu Phe Gly Met Gly 
            100                 105                 110         


Pro Arg Gly Phe Tyr Gln Pro Gly Tyr Asn Gly Gly Ala Lys Leu Asn 
        115                 120                 125             


Leu His Met Met Cys Phe Gly Arg Asn Trp Asp Pro Gln Thr Lys Tyr 
    130                 135                 140                 


Asp Pro Tyr Tyr Arg Ser Asp Gly Ser Gln Ala Pro Pro Ile Pro Asp 
145                 150                 155                 160 


Gln Leu Ile Ser Leu Val Glu Cys Ser Ile Gln Asp Ser Gln Ala His 
                165                 170                 175     


Asp Asp Glu Ile Pro Ser Ile Tyr Pro Asp Ile Cys Ile Val Asn Phe 
            180                 185                 190         


Tyr Thr Thr Thr Gly Arg Leu Gly Leu His Gln Asp Arg Asp Glu Ser 
        195                 200                 205             


Gln Asn Ser Leu Asn Arg Gly Leu Pro Val Val Ser Ile Ser Ile Gly 
    210                 215                 220                 


Asp Ser Ala Gln Phe Met Tyr Gly Asn Asn Arg Asp Val Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Val Leu Leu Glu Ser Gly Asp Val Leu Ile Phe Gly Gly Lys 
                245                 250                 255     


Ser Arg His Ile Tyr His Gly Val Lys Thr Val Val Pro Asn Ser Ala 
            260                 265                 270         


Pro Leu Pro Leu Leu Ile Gln Ser Met Leu Arg Pro Gly Arg Leu Asn 
        275                 280                 285             


Leu Thr Phe Arg Gln Tyr 
    290                 


<210>  239
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  239

Met Ser Gly Pro Asp Ser Thr Gln Pro Asp Asp Ile Ser Glu Arg Tyr 
1               5                   10                  15      


Ser Glu Pro Ser Thr Val Thr Asn Lys Gly Ser Ser Ile Lys Arg Glu 
            20                  25                  30          


Ser Asn Lys Tyr Pro Glu Gln Ala His Ser Arg Gly Trp Thr Arg Tyr 
        35                  40                  45              


Ser Glu Lys Phe Ser Pro Thr Ser Val Asp Ser Lys His Ile Thr Ser 
    50                  55                  60                  


Ser Thr Gln Ser Lys Ser Gly Arg Leu Thr Glu Val Glu Leu Val Ser 
65                  70                  75                  80  


Asp Asp Pro Lys Glu Arg Leu Gly Leu Ala Asn Val Val Arg Lys Thr 
                85                  90                  95      


Asn Phe Thr His Phe Glu Lys Val Asn Gly Lys Asn Val Asn Val Val 
            100                 105                 110         


Gln Gly Leu Glu Leu His Thr Gln Val Phe Asp Ala Asp Glu Gln Lys 
        115                 120                 125             


Lys Ile Val Glu Ala Val Tyr Glu Phe Gln Arg Met Gly Gln Lys Gly 
    130                 135                 140                 


Arg Leu Arg Glu Arg Thr Tyr Thr Glu Pro Ser Lys Trp Met Arg Gly 
145                 150                 155                 160 


Lys Gly Arg Val Thr Ile Gln Phe Gly Cys Cys Tyr Asn Tyr Ala Val 
                165                 170                 175     


Asp Lys Asn Gly Asn Pro Pro Gly Ile Ile Arg Asp Glu Glu Val Asp 
            180                 185                 190         


Pro Leu Pro Pro Ile Phe Val Gln Met Ile Lys Arg Met Val Arg Trp 
        195                 200                 205             


His Ile Leu Pro Pro Thr Cys Val Pro Asn Ser Cys Ile Val Asn Ile 
    210                 215                 220                 


Tyr Asp Glu Gly Asp Cys Ile Pro Pro His Ile Asp His His Asp Phe 
225                 230                 235                 240 


Val Arg Pro Phe Cys Thr Ile Ser Phe Leu Thr Gln Cys Asn Ile Leu 
                245                 250                 255     


Phe Gly Ser Asn Leu Lys Ile Val Gly Pro Gly Glu Phe Ser Gly Pro 
            260                 265                 270         


Val Ser Ile Pro Leu Pro Val Gly Ser Val Leu Val Leu Lys Gly Asn 
        275                 280                 285             


Gly Ala Asp Val Ala Lys His Cys Val Pro Ala Val Pro Ala Lys Arg 
    290                 295                 300                 


Ile Ser Ile Thr Phe Arg Lys Met His Glu Ser Lys Ile Pro Tyr Gly 
305                 310                 315                 320 


Phe Ser Pro Asp Pro Glu Leu Arg Gly Val Arg Pro Leu Ala Met Thr 
                325                 330                 335     


Pro Leu Glu Ser Pro Ser Gln Gln Lys His Ile Glu Asn Lys Glu Ala 
            340                 345                 350         


Ser Ser His Thr Pro Ala Ser Ala Pro Pro Gln Val Val Ser Lys Pro 
        355                 360                 365             


Asn Asn Ala Ser Leu Phe Asn Lys Glu Asp Glu Phe Pro Pro Leu Gly 
    370                 375                 380                 


Ala Met Asn Ala Ser Arg Arg Arg Arg 
385                 390             


<210>  240
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  240

Met Ser Val Lys Glu Gly Leu Val Ser Ile Leu Lys Gly Leu Ser Arg 
1               5                   10                  15      


Asp Glu Ile Glu Glu Leu Leu Leu Asn Gln Glu Leu Cys Gly His Cys 
            20                  25                  30          


Glu Leu Ser Leu His Asn His Val Gln Leu Ile His Lys Ser Lys His 
        35                  40                  45              


Asp Asn Lys Ser Ser Met Ser Gly Pro Asp Ser Thr Gln Pro Asp Asp 
    50                  55                  60                  


Ile Ser Glu Arg Tyr Ser Glu Pro Ser Thr Val Thr Asn Lys Gly Ser 
65                  70                  75                  80  


Ser Ile Lys Arg Glu Ser Asn Lys Tyr Pro Glu Gln Ala His Ser Arg 
                85                  90                  95      


Gly Trp Thr Arg Tyr Ser Glu Lys Phe Ser Pro Thr Ser Val Asp Ser 
            100                 105                 110         


Lys His Ile Thr Ser Ser Thr Gln Ser Lys Ser Gly Arg Leu Thr Glu 
        115                 120                 125             


Val Glu Leu Val Ser Asp Asp Pro Lys Glu Arg Leu Gly Leu Ala Asn 
    130                 135                 140                 


Val Val Arg Lys Thr Asn Phe Thr His Phe Glu Lys Val Asn Gly Lys 
145                 150                 155                 160 


Asn Val Asn Val Val Gln Gly Leu Glu Leu His Thr Gln Val Phe Asp 
                165                 170                 175     


Ala Asp Glu Gln Lys Lys Ile Val Glu Ala Val Tyr Glu Phe Gln Arg 
            180                 185                 190         


Met Gly Gln Lys Gly Arg Leu Arg Glu Arg Thr Tyr Thr Glu Pro Ser 
        195                 200                 205             


Lys Trp Met Arg Gly Lys Gly Arg Val Thr Ile Gln Phe Gly Cys Cys 
    210                 215                 220                 


Tyr Asn Tyr Ala Val Asp Lys Asn Gly Asn Pro Pro Gly Ile Ile Arg 
225                 230                 235                 240 


Asp Glu Glu Val Asp Pro Leu Pro Pro Ile Phe Val Gln Met Ile Lys 
                245                 250                 255     


Arg Met Val Arg Trp His Ile Leu Pro Pro Thr Cys Val Pro Asn Ser 
            260                 265                 270         


Cys Ile Val Asn Ile Tyr Asp Glu Gly Asp Cys Ile Pro Pro His Ile 
        275                 280                 285             


Asp His His Asp Phe Val Arg Pro Phe Cys Thr Ile Ser Phe Leu Thr 
    290                 295                 300                 


Gln Cys Asn Ile Leu Phe Gly Ser Asn Leu Lys Ile Val Gly Pro Gly 
305                 310                 315                 320 


Glu Phe Ser Gly Pro Val Ser Ile Pro Leu Pro Val Gly Ser Val Leu 
                325                 330                 335     


Val Leu Lys Gly Asn Gly Ala Asp Val Ala Lys His Cys Val Pro Ala 
            340                 345                 350         


Val Pro Ala Lys Arg Ile Ser Ile Thr Phe Arg Lys Met His Glu Ser 
        355                 360                 365             


Lys Ile Pro Tyr Gly Phe Ser Pro Asp Pro Glu Leu Arg Gly Val Arg 
    370                 375                 380                 


Pro Leu Ala Met Thr Pro Leu Glu Ser Pro Ser Gln Gln Lys His Ile 
385                 390                 395                 400 


Glu Asn Lys Glu Ala Ser Ser His Thr Pro Ala Ser Ala Pro Pro Gln 
                405                 410                 415     


Val Val Ser Lys Pro Asn Asn Ala Ser Leu Phe Asn Lys Glu Asp Glu 
            420                 425                 430         


Phe Pro Pro Leu Gly Ala Met Asn Ala Ser Arg Arg Arg Arg 
        435                 440                 445     


<210>  241
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  241

Met Val Ser Ala Lys Ser Pro Glu Leu Glu Ser Thr Asp Lys Arg Leu 
1               5                   10                  15      


Thr Lys Arg Lys Met Gly Asp Arg Glu Lys Glu Gly Lys Lys Ser Lys 
            20                  25                  30          


Thr Asn Trp Pro Val Ile Lys Ala Lys Ser Asn Leu Arg Val Thr Arg 
        35                  40                  45              


Leu Lys Asp Phe Asp Leu Phe Thr Val Lys Asn Cys Leu Thr Pro Ala 
    50                  55                  60                  


Glu Ser Asn Ala Phe Val Lys Ala Ala Glu Thr Ile Gly Phe Val His 
65                  70                  75                  80  


Gln Gly Ser Leu Gly Pro Thr Met Gly Glu Ala Tyr Arg Asp Asn Asp 
                85                  90                  95      


Arg Ile Ala Val Asp Asp Pro Val Leu Ala Asp Thr Leu Trp Glu Ser 
            100                 105                 110         


Gly Leu Asn Lys Leu Phe Thr Asp Leu Thr Ile Arg Gly Arg Val Ala 
        115                 120                 125             


Val Gly Leu Asn Pro Asn Ile Arg Leu Tyr Arg Tyr Lys Val Gly Gln 
    130                 135                 140                 


Arg Phe Gly Arg His Ile Asp Glu Ser Val Asp Ile Gly Glu Gly Lys 
145                 150                 155                 160 


Arg Thr His Tyr Thr Leu Leu Ile Tyr Leu Asn Gly Gly Glu Ser Lys 
                165                 170                 175     


Ala Lys Ser Asp Val Asn Gly Ser His Asp Ser Ser Glu Pro Leu Val 
            180                 185                 190         


Gly Gly Glu Thr Val Phe Tyr Gly Ser Arg Asn Ser Leu Val Ala Glu 
        195                 200                 205             


Val Ser Pro Ala Gln Gly Met Ala Leu Phe His Leu His Gly Ala Lys 
    210                 215                 220                 


Cys Met Leu His Glu Ser Arg Asn Val Ala Lys Gly Val Lys Tyr Ile 
225                 230                 235                 240 


Leu Arg Ser Asp Val Val Phe Ala 
                245             


<210>  242
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  242

Met Ile Asn Gly Ala Pro Val Glu Glu Glu Asp Asp Pro Phe Leu Ser 
1               5                   10                  15      


Gly Tyr Asn Asp Ala Asp Leu Arg Thr Val Ser Glu Phe Leu Ser Asn 
            20                  25                  30          


Trp Leu Pro Phe Leu Ser Lys Gly Leu Cys His His Cys Ser Asp Ser 
        35                  40                  45              


Leu Val His Arg Val His Ser Leu Asn Arg Phe Glu Tyr Ala Ser Glu 
    50                  55                  60                  


Gln Ser His Gln Glu Val Glu Val His Leu Ser Thr Pro Asn His Thr 
65                  70                  75                  80  


Asp Leu Lys Asp Glu Thr Tyr Ile Val Asp Thr Glu Asp Thr Asn Ser 
                85                  90                  95      


Leu Gly Ser Trp Lys Asp Gly Ala Tyr Gly Val Ser Gly His Ile Glu 
            100                 105                 110         


Glu Thr Ser Gly Ser Glu Arg Val Gln Ser Pro Glu Tyr Phe Lys Thr 
        115                 120                 125             


Pro Thr Pro Arg Arg Ser Trp Ala Asp Met Ala Gln Glu Glu Leu Glu 
    130                 135                 140                 


Ala Asp Glu Glu Glu Glu Thr Arg Glu His Phe Gly Asn Tyr Asn Gly 
145                 150                 155                 160 


Arg Leu Gln Gly Lys Gly Glu Val Arg Thr Ala Gln Lys Leu Glu Leu 
                165                 170                 175     


Ser Arg Glu Gln Arg Glu Arg Ile Arg Phe Thr Asn Val Thr Arg Lys 
            180                 185                 190         


Lys Asp Phe Ile Cys Leu Glu Arg Val Asn Gly Lys Leu Val Asn Ile 
        195                 200                 205             


Leu Glu Gly Leu Glu Leu His Tyr Gly Val Phe Ser Ser Pro Glu Gln 
    210                 215                 220                 


Lys Arg Ile Val Asn Phe Val Tyr Glu Leu Gln Glu Lys Gly Lys Asn 
225                 230                 235                 240 


Gly Lys Leu Lys Glu Arg Thr Phe Thr Ala Pro Gln Lys Trp Met Arg 
                245                 250                 255     


Gly Lys Gly Arg Val Thr Ile Gln Phe Gly Cys Cys Tyr Asn Tyr Ala 
            260                 265                 270         


Thr Asp Arg Asn Gly Asn Pro Pro Gly Ile Leu Arg Asn Glu Leu Val 
        275                 280                 285             


Asp Pro Ile Pro His Leu Phe Lys Val Ile Ile Lys Arg Leu Val Ala 
    290                 295                 300                 


Trp His Val Leu Pro Pro Thr Cys Val Pro Asp Ser Cys Ile Val Asn 
305                 310                 315                 320 


Ile Tyr Asp Glu Gly Asp Cys Ile Pro Pro His Ile Asp Asn His Asp 
                325                 330                 335     


Phe Leu Arg Pro Phe Cys Thr Val Ser Phe Leu Ser Glu Cys Asn Ile 
            340                 345                 350         


Leu Phe Gly Ser Lys Leu Glu Ile Gln Gly Pro Gly Glu Phe Ser Gly 
        355                 360                 365             


Ser Tyr Lys Ile Pro Leu Pro Val Gly Ser Val Leu Val Leu Asn Gly 
    370                 375                 380                 


Asn Gly Ala Asp Val Ala Lys His Cys Val Pro Ala Val Pro Thr Lys 
385                 390                 395                 400 


Arg Ile Ser Ile Thr Phe Arg Lys Met Asp Glu Ser Lys Trp Pro Ala 
                405                 410                 415     


Gly Phe His Pro Glu Pro Asp Leu Gln Gly Leu Glu Pro Leu Val Tyr 
            420                 425                 430         


Glu Ser Asp Thr Pro Lys Gly Gly Ser Ser Ile Ser Lys Pro Gln Ser 
        435                 440                 445             


Gln Val Ser Asn Arg Gln Ala Phe Arg Arg Asp Gly Phe Val Ala Glu 
    450                 455                 460                 


Thr Asp Leu Arg Gly Leu Glu Pro Val Ala Tyr Glu Ser Asp Arg Pro 
465                 470                 475                 480 


Lys Ser Ser Ser Ser Ile Ser Lys Pro His Ser His Pro Ser Asn Arg 
                485                 490                 495     


Gln Gly Phe Arg Arg Asp Gly Phe Ala Pro Glu Pro Asp Leu Arg Gly 
            500                 505                 510         


Leu Glu Arg Val Ser Gly Ser Ser Ile Ser Lys Pro Gln Ser Gln Phe 
        515                 520                 525             


Ser Asn Arg Gln Ala Ser Arg Arg Asp Gly Phe Val Ala Glu Pro Asp 
    530                 535                 540                 


Leu Arg Arg Leu Glu Pro Val Ala Tyr Glu Ser Asp Arg Pro Lys Ser 
545                 550                 555                 560 


Val Ser Ser Ile Ser Lys Pro His Ile His Pro Ser Asn Arg Glu Pro 
                565                 570                 575     


Tyr Arg Arg Asp Glu Thr Arg Gly Leu Leu Gly Ser Gln Pro Arg Phe 
            580                 585                 590         


Tyr Gly Gln Ser Gln Thr Arg Gln Gln Gly Pro Ser Pro Gly Tyr Arg 
        595                 600                 605             


Arg Asn Gly Arg Leu Glu Tyr 
    610                 615 


<210>  243
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  243

Met Ile Asn Asn Gly Ala Pro Val Glu Glu Glu Asp Asp Pro Phe Leu 
1               5                   10                  15      


Ser Gly Tyr Asn Asp Ala Asp Leu Arg Thr Val Ser Glu Phe Leu Ser 
            20                  25                  30          


Asn Trp Leu Pro Phe Leu Ser Lys Gly Leu Cys His His Cys Ser Asp 
        35                  40                  45              


Ser Leu Val His Arg Val His Ser Leu Asn Arg Phe Glu Tyr Ala Ser 
    50                  55                  60                  


Glu Gln Ser His Gln Glu Val Glu Val His Leu Ser Thr Pro Asn His 
65                  70                  75                  80  


Thr Asp Leu Lys Asp Glu Thr Tyr Ile Val Asp Thr Glu Asp Thr Asn 
                85                  90                  95      


Ser Leu Gly Ser Trp Lys Asp Gly Ala Tyr Gly Val Ser Gly His Ile 
            100                 105                 110         


Glu Glu Thr Ser Gly Ser Glu Arg Val Gln Ser Pro Glu Tyr Phe Lys 
        115                 120                 125             


Thr Pro Thr Pro Arg Arg Ser Trp Ala Asp Met Ala Gln Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp Glu Glu Glu Glu Thr Arg Glu His Phe Gly Asn Tyr Asn 
145                 150                 155                 160 


Gly Arg Leu Gln Gly Lys Gly Glu Val Arg Thr Ala Gln Lys Leu Glu 
                165                 170                 175     


Leu Ser Arg Glu Gln Arg Glu Arg Ile Arg Phe Thr Asn Val Thr Arg 
            180                 185                 190         


Lys Lys Asp Phe Ile Cys Leu Glu Arg Val Asn Gly Lys Leu Val Asn 
        195                 200                 205             


Ile Leu Glu Gly Leu Glu Leu His Tyr Gly Val Phe Ser Ser Pro Glu 
    210                 215                 220                 


Gln Lys Arg Ile Val Asn Phe Val Tyr Glu Leu Gln Glu Lys Gly Lys 
225                 230                 235                 240 


Asn Gly Lys Leu Lys Glu Arg Thr Phe Thr Ala Pro Gln Lys Trp Met 
                245                 250                 255     


Arg Gly Lys Gly Arg Val Thr Ile Gln Phe Gly Cys Cys Tyr Asn Tyr 
            260                 265                 270         


Ala Thr Asp Arg Asn Gly Asn Pro Pro Gly Ile Leu Arg Asn Glu Leu 
        275                 280                 285             


Val Asp Pro Ile Pro His Leu Phe Lys Val Ile Ile Lys Arg Leu Val 
    290                 295                 300                 


Ala Trp His Val Leu Pro Pro Thr Cys Val Pro Asp Ser Cys Ile Val 
305                 310                 315                 320 


Asn Ile Tyr Asp Glu Gly Asp Cys Ile Pro Pro His Ile Asp Asn His 
                325                 330                 335     


Asp Phe Leu Arg Pro Phe Cys Thr Val Ser Phe Leu Ser Glu Cys Asn 
            340                 345                 350         


Ile Leu Phe Gly Ser Lys Leu Glu Ile Gln Gly Pro Gly Glu Phe Ser 
        355                 360                 365             


Gly Ser Tyr Lys Ile Pro Leu Pro Val Gly Ser Val Leu Val Leu Asn 
    370                 375                 380                 


Gly Asn Gly Ala Asp Val Ala Lys His Cys Val Pro Ala Val Pro Thr 
385                 390                 395                 400 


Lys Arg Ile Ser Ile Thr Phe Arg Lys Met Asp Glu Ser Lys Trp Pro 
                405                 410                 415     


Ala Gly Phe His Pro Glu Pro Asp Leu Gln Gly Leu Glu Pro Leu Val 
            420                 425                 430         


Tyr Glu Ser Asp Thr Pro Lys Gly Gly Ser Ser Ile Ser Lys Pro Gln 
        435                 440                 445             


Ser Gln Val Ser Asn Arg Gln Ala Phe Arg Arg Asp Gly Phe Val Ala 
    450                 455                 460                 


Glu Thr Asp Leu Arg Gly Leu Glu Pro Val Ala Tyr Glu Ser Asp Arg 
465                 470                 475                 480 


Pro Lys Ser Ser Ser Ser Ile Ser Lys Pro His Ser His Pro Ser Asn 
                485                 490                 495     


Arg Gln Gly Phe Arg Arg Asp Gly Phe Ala Pro Glu Pro Asp Leu Arg 
            500                 505                 510         


Gly Leu Glu Arg Val Ser Gly Ser Ser Ile Ser Lys Pro Gln Ser Gln 
        515                 520                 525             


Phe Ser Asn Arg Gln Ala Ser Arg Arg Asp Gly Phe Val Ala Glu Pro 
    530                 535                 540                 


Asp Leu Arg Arg Leu Glu Pro Val Ala Tyr Glu Ser Asp Arg Pro Lys 
545                 550                 555                 560 


Ser Val Ser Ser Ile Ser Lys Pro His Ile His Pro Ser Asn Arg Glu 
                565                 570                 575     


Pro Tyr Arg Arg Asp Glu Thr Arg Gly Leu Leu Gly Ser Gln Pro Arg 
            580                 585                 590         


Phe Tyr Gly Gln Ser Gln Thr Arg Gln Gln Gly Pro Ser Pro Gly Tyr 
        595                 600                 605             


Arg Arg Asn Gly Arg Leu Glu Tyr 
    610                 615     


<210>  244
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  244

Met Gly Ser Glu Ala Pro Phe Gln Leu Pro Val Val Asp Phe Ser Ala 
1               5                   10                  15      


Leu Asn Lys Gln Asn Pro Asp Ile Val Ile Trp Glu Ser Ala Lys Thr 
            20                  25                  30          


Lys Ala Ile Glu Ala Leu Gln Glu Tyr Gly Cys Phe Glu Ala Thr Phe 
        35                  40                  45              


Asp Glu Ile Ser Pro Asp Leu Gln Lys Ser Val Phe Ser Glu Leu Glu 
    50                  55                  60                  


Asn Leu Phe Asn Leu Pro Leu Glu Thr Lys Gln Arg Asn Ala Asn Asp 
65                  70                  75                  80  


Arg Glu Phe His Gly Tyr Ile Gly Gln Ile Pro Phe Met Pro Leu Tyr 
                85                  90                  95      


Glu Ser Met Gly Ile Asp Thr Pro Tyr Val Gln Glu Lys Val Asp Glu 
            100                 105                 110         


Phe Thr Asn Val Met Trp Pro Gln Gly Asn Pro Lys Phe Ser Lys Ser 
        115                 120                 125             


Ile Gln Ala Tyr Ser Lys Lys Leu Trp Glu Leu Asp Glu Met Val Lys 
    130                 135                 140                 


Lys Met Val Phe Glu Gly Leu Asn Leu Arg Lys Tyr Leu Glu Glu His 
145                 150                 155                 160 


Leu Glu Ala Thr Ser Tyr His Leu Lys Val Met Lys Tyr Arg Val Ala 
                165                 170                 175     


Asp Pro Ser Glu Ser Thr Met Gly Leu Asp Ser His Ala Asp Thr Ser 
            180                 185                 190         


Ile Leu Thr Ile Leu His Gln Asn Gly Val Gln Gly Leu Glu Leu Arg 
        195                 200                 205             


Thr Lys Asp Glu Thr Trp Val Thr Val Asn Val Ser Pro Asn Ser Phe 
    210                 215                 220                 


Val Val Met Ala Gly Glu Ser Phe Asn Val Leu Ser Asn Gly Arg Leu 
225                 230                 235                 240 


His Ala Pro Phe His Arg Val Val Met Asn Ala Asn Lys Thr Arg Leu 
                245                 250                 255     


Ser Val Gly Leu Phe Ser Met Pro Lys Val Gly Ser Ile Val Lys Pro 
            260                 265                 270         


Pro Lys Glu Met Val Asp Glu Glu His Pro Leu Leu Phe Lys Pro Phe 
        275                 280                 285             


Asp Tyr Gly Glu Phe Met Asp Tyr Phe Cys Met Ala Gly Val Lys Lys 
    290                 295                 300                 


Asp Thr Tyr Gly Leu Lys Thr Tyr Cys Gly Leu Ser Ile 
305                 310                 315         


<210>  245
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  245

Met Glu Ile Lys Lys Asp Lys Asp Ser Arg Trp Phe Asp Val Glu Leu 
1               5                   10                  15      


Val Pro Glu Ser Tyr Ile Phe Ser Pro Thr Asp Arg Pro Gln Asn Leu 
            20                  25                  30          


Asp Val Ala Ile Cys Asp Ser Ile Pro Val Ile Asp Leu Ala Lys His 
        35                  40                  45              


Ile Gln Pro Ile Glu Ser Ile Leu Lys Ala Ser Gln Glu Phe Gly Phe 
    50                  55                  60                  


Phe Gln Val Ile Asn His Gly Val Pro Glu Lys Ile Met Ser Asp Ala 
65                  70                  75                  80  


Met Ser Val Leu Lys Glu Phe Phe His Met Pro Ser Lys Glu Ala Thr 
                85                  90                  95      


Gly Tyr Val Pro His Asn Lys Gly Trp Ile Tyr Thr Asn Asn Asp Cys 
            100                 105                 110         


Thr Lys Asp Gly Val His Ile Trp Arg Glu Asn Leu Lys His Leu Cys 
        115                 120                 125             


His Pro Leu Asp Lys Cys Thr Lys Leu Trp Pro Asn Lys Pro Thr Arg 
    130                 135                 140                 


Tyr Gln Glu Val Ile Ala Ala Tyr Leu Leu Glu Ile Asn Lys Leu Ser 
145                 150                 155                 160 


Phe Arg Ile Leu Glu Met Ile Cys Glu Gly Leu Gly Leu Glu Pro Gly 
                165                 170                 175     


Tyr Leu Ser Asp Thr Ser Glu Val Gln Ile Leu Ser Ser Asn Phe Tyr 
            180                 185                 190         


Pro Ser Cys Pro Asp Pro Ser Leu Thr Leu Gly Ile Leu Ala His Gln 
        195                 200                 205             


Asp Thr Ser Leu Ile Thr Leu Val Tyr Gln Gly Asp Ser Thr Gly Leu 
    210                 215                 220                 


Gln Phe Leu Lys Asp Gly Gln Trp Ile Asn Val Gly Ser Ile Pro Asn 
225                 230                 235                 240 


Ser Phe Val Val Asn Ile Gly Asn Gln Leu Glu Ile Val Ser Asn Gly 
                245                 250                 255     


Lys Leu Arg Ser Ile Asp His Arg Val Val Thr Ser Lys Asp Lys Thr 
            260                 265                 270         


Arg Ile Ser Ile Ala Thr Phe Val Asn Pro Ser Tyr Asp Cys Ile Ile 
        275                 280                 285             


Glu Pro Ala Lys Ala Leu Val Asn Lys Asn Glu Pro Ser Arg Tyr Lys 
    290                 295                 300                 


Ala Ser Arg Tyr Lys Glu Tyr Val Asp Arg Asn Lys Ala Phe Gly Asp 
305                 310                 315                 320 


Tyr Thr Val Ala Leu Arg Asp Val Val Ile Ser Glu Ser 
                325                 330             


<210>  246
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  246

Met Ala Gln Glu Asp Leu Glu Ala Asp Glu Glu Val Glu Ala Arg Lys 
1               5                   10                  15      


Arg Phe Gly Asn Tyr Asn Gly Arg Leu Gln Gly Lys Gly Glu Val Arg 
            20                  25                  30          


Thr Ala Gln Lys Pro Val Leu Ser Arg Glu Gln Arg Glu Arg Ile Arg 
        35                  40                  45              


Phe Thr Asn Val Thr Arg Lys Lys Asp Phe Ile Cys Val Glu Arg Val 
    50                  55                  60                  


Asn Gly Lys Leu Val Asn Ile Leu Glu Gly Leu Glu Leu His Cys Gly 
65                  70                  75                  80  


Val Phe Ser Leu Glu Glu Gln Gly Trp Ile Val Asn Phe Val Tyr Glu 
                85                  90                  95      


Leu Gln Glu Lys Gly Lys Asn Gly Lys Leu Lys Glu Ser Ser Ala Pro 
            100                 105                 110         


Gln Lys Trp Met Arg Gly Lys Gly Arg Val Thr Ile Gln Phe Gly Cys 
        115                 120                 125             


Cys Tyr Asn Tyr Ala Thr Asp Arg Asn Gly Asn Pro Pro Gly Ile Leu 
    130                 135                 140                 


His Asn Glu Leu Val Asp Pro Ile Pro His Pro Phe Lys Ser Ile Ile 
145                 150                 155                 160 


Lys Arg Leu Val Ala Trp His Val Phe Pro Pro Thr Cys Val Pro Asp 
                165                 170                 175     


Ser Cys Ile Val Asn Ile Tyr Asp Glu Gly Asp Cys Ile Pro Pro His 
            180                 185                 190         


Ile Asp Asn His Asp Phe Leu Arg Pro Phe Cys Thr Val Ser Phe Leu 
        195                 200                 205             


Ser Glu Cys Asn Ile Leu Phe Gly Ser Asn Leu Lys Ile Asp Gly Pro 
    210                 215                 220                 


Gly Glu Phe Ser Gly Ser Tyr Lys Ile Pro Leu Pro Val Gly Ser Val 
225                 230                 235                 240 


Leu Val Leu Asn Gly Asn Gly Ala Asp Val Ala Lys His Cys Val Pro 
                245                 250                 255     


Ala Val Pro Thr Lys Arg Ile Ser Ile Thr Phe Arg Lys Met Asp Glu 
            260                 265                 270         


Ser Lys Trp Pro Ala Gly Phe His Pro Glu Pro Asp Leu Gln Gly Leu 
        275                 280                 285             


Glu Pro Leu Val Tyr Glu Ser Asp Thr Pro Lys Ser Gly Ser Ser Ile 
    290                 295                 300                 


Ser Lys Pro Gln Ser Gln Phe Ser Asn Arg Gln Ala Phe Arg Arg Asp 
305                 310                 315                 320 


Arg Phe Val Ala Glu Thr Asp Leu Arg Gly Leu Glu Pro Val Ala Tyr 
                325                 330                 335     


Glu Ser Asp Arg Pro Lys Ser Gly Ser Asn Ile Ser Lys Pro His Ser 
            340                 345                 350         


His Pro Ser Asn Arg Gln Val Phe Gly Arg Asp Gly Phe Ala Pro Glu 
        355                 360                 365             


Pro Asp Leu Arg Gly Leu Glu Arg Val Ser Gly Ser Ser Ile Ser Lys 
    370                 375                 380                 


Pro His Ser Gln Phe Leu Asn Arg Lys Ala Ser Arg Arg Asp Gly Phe 
385                 390                 395                 400 


Val Ala Glu Pro Asp Leu Arg Arg Leu Glu Pro Val Ala Tyr Glu Ser 
                405                 410                 415     


Asp Arg Pro Lys Ser Val Ser Ser Ile Ser Lys Pro His Ile His Pro 
            420                 425                 430         


Ser Asn Arg Glu Pro Tyr Arg Arg Asp Asp Ala Arg Gly Leu Leu Gly 
        435                 440                 445             


Leu Glu Pro Arg Phe Tyr Gly Gln Ser Gln Thr Arg Gln Gln Gly Pro 
    450                 455                 460                 


Ser Pro Gly Tyr Arg Arg Lys Ala Ser Lys Ala Asn Ala Ile His Met 
465                 470                 475                 480 


Leu Ile Leu Val Ser Gln Ser His Arg Asn Val Ile His Gly Glu Trp 
                485                 490                 495     


Gln Thr Arg Tyr Ile Gly Ser Val Ser Leu Leu Val Lys Lys Phe Asp 
            500                 505                 510         


Leu His Gln Ala Val Ser Lys Lys Leu Ser Cys 
        515                 520             


<210>  247
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  247

Met Gly Gln Val Asp Pro Thr Phe Ile Gln Glu Leu Glu His Arg Pro 
1               5                   10                  15      


Lys Pro Val Val Ile Glu Ala Gln Gly Ile Pro Gln Ile Asp Leu Ser 
            20                  25                  30          


Pro Ser Val Pro Ile Gln Glu Leu Val Asp Gln Ile His Asp Ala Cys 
        35                  40                  45              


Lys Asn Trp Gly Phe Phe Gln Val Ile Asn His Gly Val Pro Ile Glu 
    50                  55                  60                  


Ser Arg Glu Lys Val Gln Lys Ala Ala Lys Arg Phe Phe Asp Gln Thr 
65                  70                  75                  80  


Thr Glu Glu Lys Arg Lys Val Lys Arg Asp Glu Ala Asn Pro Leu Gly 
                85                  90                  95      


Tyr Tyr Asp Thr Glu His Thr Lys Asn Val Arg Asp Trp Lys Glu Val 
            100                 105                 110         


Phe Asp Phe Val Val Glu Val Pro Thr Leu Met Ser Ala Ser Tyr Glu 
        115                 120                 125             


Ala Asp Asp Asp Glu Ile Thr Glu Tyr Arg Asn Gln Trp Pro His His 
    130                 135                 140                 


Pro Ser Glu Leu Arg Glu Ala Cys Glu Glu Tyr Val Lys Asp Val Gln 
145                 150                 155                 160 


Lys Leu Ser Asn Lys Leu Leu Glu Leu Ile Ser Leu Ser Leu Asn Leu 
                165                 170                 175     


Pro Ala Lys Arg Leu Glu Pro Phe Phe Lys Asp Gln Thr Thr Phe Val 
            180                 185                 190         


Arg Leu Asn His Tyr Pro Pro Cys Leu Ala Pro Asp Leu Ala Leu Gly 
        195                 200                 205             


Val Gly Arg His Lys Asp Ala Gly Ala Leu Thr Ile Leu Ala Gln Asp 
    210                 215                 220                 


Asp Val Gly Gly Leu Glu Val Lys Arg Lys Thr Asp Gly Glu Trp Ile 
225                 230                 235                 240 


Phe Val Lys Pro Thr Pro Asn Ala Phe Ile Ile Asn Val Gly Asp Ile 
                245                 250                 255     


Ile Gln Val Trp Ser Asn Asp Thr Tyr Glu Ser Val Glu His Arg Val 
            260                 265                 270         


Arg Val Asn Ser Thr Arg Glu Arg Phe Ser Ile Pro Phe Phe Ala Asn 
        275                 280                 285             


Pro Ala His Tyr Thr Met Val Glu Pro Leu Pro Glu Leu Thr Asn Ala 
    290                 295                 300                 


Gln Asn Pro Pro Lys Tyr Lys Ala Tyr Asn Trp Gly Lys Phe Phe Ala 
305                 310                 315                 320 


Thr Arg Lys Arg Ser Asn Phe Lys Lys Leu Asp Val Glu Asn Ile Gln 
                325                 330                 335     


Ile Tyr His Phe Lys Lys Ser Asp Glu Arg Lys Ile Asp Asp Val Val 
            340                 345                 350         


Ser Arg Ile Glu Asn Val Val Ile 
        355                 360 


<210>  248
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  248

Met Thr Arg Thr Thr Glu Pro Phe Ser Leu Ile Ile Pro Thr Asn Gln 
1               5                   10                  15      


Val Cys Lys Thr Leu Gly Val Thr Pro Ala Glu Asn Glu Asn Lys Val 
            20                  25                  30          


Lys Ser Ser Tyr Lys Val Leu Arg Pro Gly Met Ile Leu Leu Lys Asn 
        35                  40                  45              


Tyr Leu Ser Leu Ser Asp Gln Val Glu Ile Val His Ile Cys Glu Glu 
    50                  55                  60                  


Leu Gly Ile Gly Pro Gly Gly Phe Gly Gln Pro Gly Tyr Glu Asp Gly 
65                  70                  75                  80  


Arg Lys Leu Gln Leu Gln Met Leu Cys Leu Gly Arg Tyr Trp Asp Pro 
                85                  90                  95      


Gln Thr Arg Tyr Ser Lys Gly Tyr Gly Phe Lys Val Pro Gln Ile Pro 
            100                 105                 110         


Asp Lys Phe Ile Ser Leu Val Glu Thr Ala Leu Gln Asp Ser Gln Thr 
        115                 120                 125             


Leu Met Asn Ser Glu Asp Glu Leu Pro Trp Met Ser Pro Asn Ile Gly 
    130                 135                 140                 


Ile Val Asn Phe Tyr Thr Ala Thr Gly Arg Leu Gly Ile His Gln Asp 
145                 150                 155                 160 


Arg Asp Glu Ser Trp Asp Ser Ile Ser Lys Gly Ser Pro Val Val Ser 
                165                 170                 175     


Ile Ser Ile Gly Asp Ser Ala Glu Phe Leu Tyr Gly Asp Lys Arg Asp 
            180                 185                 190         


Val Asp Lys Leu Asp Lys Val Val Leu Glu Ser Gly Asp Ile Leu Ile 
        195                 200                 205             


Phe Gly Gly Lys Ser Arg Asn Val Tyr His Gly Val Lys Ala Ile Ile 
    210                 215                 220                 


Pro Asn Ser Ala Pro Glu Val Leu Leu Lys Glu Ser Met Leu Arg Pro 
225                 230                 235                 240 


Gly Arg Leu Asn Leu Thr Phe Arg Gln Tyr 
                245                 250 


<210>  249
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  249

Met Tyr Gly Ser Glu Asn Leu Asn Glu Asp Ser Glu Arg Thr Ala Phe 
1               5                   10                  15      


Arg Lys Thr Glu Lys Lys Tyr Lys Leu Tyr Tyr Asp Ser Asn Lys Lys 
            20                  25                  30          


Lys Lys Lys Leu Pro Arg Ala Val Asp Leu Ser Asp Val Ile Asp Phe 
        35                  40                  45              


Lys Ala Ile Ser Glu Ser Phe Val Arg Asn Glu Glu Leu Pro Val Gly 
    50                  55                  60                  


Val Ser Lys Ala Gln Ser Arg Phe Asp Asn Pro Val Phe Cys Leu Asp 
65                  70                  75                  80  


Ala Cys Pro Gly Phe Tyr Phe Ile Pro Ala Ala Leu Ser Ile Glu Glu 
                85                  90                  95      


Gln His Lys Trp Ile Lys Glu Ser Leu Val Ser Phe Pro Gln Pro Pro 
            100                 105                 110         


Asn Arg Thr Asn His Asn Ala Val Tyr Gly Pro Ile His Ser Leu Phe 
        115                 120                 125             


Arg Ala Ala Asn Asp Lys Gln Ile Leu Val Glu Glu Ala Asn Asp Val 
    130                 135                 140                 


Glu Gly Asp Val Cys Ser His Arg Trp Ala Ser Ser Glu Glu Ile Asp 
145                 150                 155                 160 


Ser Ser Leu Asn Gly Asn Ser Cys Lys Ser Ile Ser Ala Ser Val Leu 
                165                 170                 175     


Leu Arg Lys Leu Arg Trp Ser Thr Leu Gly Leu Gln Phe Asp Trp Ser 
            180                 185                 190         


Lys Arg Gly Tyr Asn Val Ser Leu Pro His Asn Lys Ile Pro Asp Ala 
        195                 200                 205             


Leu Ser Gln Leu Ala Lys Lys Met Ala Ala Pro Ala Met Pro Ala Gly 
    210                 215                 220                 


Glu Asp Phe Gln Pro Glu Ala Ala Ile Val Asn Tyr Phe Gly Ser Gly 
225                 230                 235                 240 


Asp Met Leu Gly Gly His Leu Asp Asp Met Glu Val Asp Trp Ser Lys 
                245                 250                 255     


Pro Ile Val Ser Met Ser Leu Gly Cys Lys Ala Ile Phe Leu Leu Gly 
            260                 265                 270         


Gly Lys Ser Arg Asn Asp Glu Pro Leu Ala Met Phe Leu Arg Ser Gly 
        275                 280                 285             


Asp Ile Val Leu Met Ser Gly Glu Ala Arg Glu Arg Phe His Gly Val 
    290                 295                 300                 


Pro Arg Ile Phe Thr Asp Ala Glu His Ala Glu Ile Gly Ser Leu Glu 
305                 310                 315                 320 


Lys Leu Leu Ser Asp Glu Asp Asp Ile Cys Tyr Leu Glu Tyr Ile Lys 
                325                 330                 335     


Thr Ser Arg Ile Asn Ile Asn Ile Arg Gln Val Phe 
            340                 345             


<210>  250
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  250

Met Tyr Gly Ser Glu Asn Leu Asn Asp Asp Ser Glu Arg Thr Ala Phe 
1               5                   10                  15      


Arg Lys Thr Glu Lys Lys Tyr Lys Leu Tyr Tyr Asp Ser Asn Lys Lys 
            20                  25                  30          


Lys Lys Lys Leu Pro Arg Ala Val Asp Leu Ser Asp Val Ile Asp Phe 
        35                  40                  45              


Lys Ala Ile Ser Glu Ser Phe Asp Arg Asn Glu Glu Leu Pro Val Gly 
    50                  55                  60                  


Val Ser Lys Ala Gln Ser Arg Phe Asp Asn Pro Val Phe Cys Leu Asp 
65                  70                  75                  80  


Ala Cys Pro Gly Phe Tyr Phe Ile Pro Ala Ala Leu Ser Val Glu Glu 
                85                  90                  95      


Gln His Lys Trp Ile Lys Glu Ser Leu Val Ser Phe Pro Gln Pro Pro 
            100                 105                 110         


Asn Arg Thr Asn His Asn Val Val Tyr Gly Pro Ile His Ser Leu Phe 
        115                 120                 125             


Arg Ala Ala Asn Asp Lys Gln Ile Leu Val Glu Glu Ala Asn Asp Val 
    130                 135                 140                 


Glu Gly Asp Val Cys Ser His Arg Trp Ala Pro Ser Glu Glu Ser Asp 
145                 150                 155                 160 


Ser Ser Leu Asn Gly Asn Ser Cys Lys Ser Ile Ser Ala Ser Val Leu 
                165                 170                 175     


Leu Arg Lys Leu Arg Trp Ser Thr Leu Gly Leu Gln Phe Asp Trp Ser 
            180                 185                 190         


Lys Arg Gly Tyr Asn Val Ser Leu Pro His Asn Lys Ile Pro Asp Ala 
        195                 200                 205             


Leu Ser Gln Leu Ala Lys Lys Met Ala Ala Pro Ala Met Pro Val Gly 
    210                 215                 220                 


Glu Asp Phe Gln Pro Glu Ala Ala Ile Val Asn Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Asp Met Leu Gly Gly His Leu Asp Asp Met Glu Val Asp Trp Ser Lys 
                245                 250                 255     


Pro Ile Val Ser Met Ser Leu Gly Cys Lys Ala Ile Phe Leu Leu Gly 
            260                 265                 270         


Gly Lys Ser Arg Asn Asp Glu Pro Leu Ala Met Phe Leu Arg Ser Gly 
        275                 280                 285             


Asp Ile Val Leu Met Ser Gly Glu Ala Arg Glu Arg Phe His Gly Val 
    290                 295                 300                 


Pro Arg Ile Phe Thr Asp Ala Glu His Ala Glu Ile Gly Ser Leu Glu 
305                 310                 315                 320 


Lys Leu Leu Ser Asp Glu Asp Asp Ile Cys Tyr Leu Glu Tyr Ile Lys 
                325                 330                 335     


Thr Ser Arg Ile Asn Ile Asn Ile Arg Gln Val Phe 
            340                 345             


<210>  251
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  251

Met Thr Arg Thr Glu Gln Pro Phe Ser Leu Ile Leu Pro Ser Asp Pro 
1               5                   10                  15      


Val Cys Lys Thr Leu Tyr Ala Glu Lys Glu Asn Lys Val Gln Ser Thr 
            20                  25                  30          


Cys Glu Val Leu Arg Ser Gly Met Ile Leu Leu Arg Asn Tyr Leu Ser 
        35                  40                  45              


Leu Ser Glu Gln Val Glu Ile Val Asn Ile Cys Glu Glu Leu Gly Ile 
    50                  55                  60                  


Gly Pro Gly Gly Phe Gly Gln Pro Gly Tyr Glu Asp Gly Arg Lys Leu 
65                  70                  75                  80  


Gln Leu Gln Met Leu Cys Leu Gly Arg Tyr Trp Asp Pro Gln Thr Arg 
                85                  90                  95      


Tyr Ser Lys Gly Tyr Gly Phe Lys Val Pro Gln Ile Pro Asp Lys Phe 
            100                 105                 110         


Ile Ser Leu Val Glu Thr Ala Leu Glu Asp Ser Gln Ser Phe Ile Lys 
        115                 120                 125             


Ser Glu Glu Asp Gln Leu Pro Trp Met Ser Pro Asn Ile Gly Ile Val 
    130                 135                 140                 


Asn Phe Tyr Thr Ala Thr Gly Arg Leu Gly Ile His Gln Asp Arg Asp 
145                 150                 155                 160 


Glu Ser Trp Asp Ser Ile Asn Lys Gly Ser Pro Val Val Ser Ile Ser 
                165                 170                 175     


Asn Gly Asp Ser Ala Glu Phe Leu Tyr Gly Asp Glu Arg Asn Lys Leu 
            180                 185                 190         


Asp Glu Val Val Leu Lys Ser Gly Asp Ile Leu Ile Phe Gly Gly Lys 
        195                 200                 205             


Lys Ser Arg Asn Ile Tyr His Gly Val Lys Ala Ile Ile Pro Asn Ser 
    210                 215                 220                 


Ala Pro Glu Ala Leu Leu Lys Ala Ser Met Leu Arg Pro Gly Arg Leu 
225                 230                 235                 240 


Asn Leu Thr Phe Arg Gln Tyr 
                245         


<210>  252
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  252

Met Glu Ala Ser Asp Pro Leu Lys Arg Tyr Lys Val Gly Ser Val Pro 
1               5                   10                  15      


Thr Val Tyr Tyr Ile Pro Asp Phe Ile Ser Asp Thr Asp Gln Thr Gln 
            20                  25                  30          


Leu Leu Asn Lys Ile Tyr Thr Ala Pro Val Ser Lys Trp Lys Ser Leu 
        35                  40                  45              


Lys Asn Arg Arg Leu Gln Asp Trp Val Pro Ser Trp Leu Thr Lys Ile 
    50                  55                  60                  


Thr Glu Lys Ile Ser Glu Glu Ser Ser Leu Phe Pro Ser Ala Ile Asn 
65                  70                  75                  80  


His Val Leu Ile Asn Glu Tyr Leu Pro Asn Gln Gly Ile Met Pro His 
                85                  90                  95      


Gln Asp Gly Pro Ala Tyr Tyr Pro Val Val Ala Ile Leu Ser Leu Gly 
            100                 105                 110         


Ser Pro Val Val Met Asp Phe Thr Pro His Ala Lys Leu Val Gly Thr 
        115                 120                 125             


Ala Ser Asn Ile Glu Asp Thr Gly Ser Ile Glu Gly Thr Asp Asp Glu 
    130                 135                 140                 


Met Leu Pro Asn His His Pro Phe Ser Ile Ala Leu Met Pro Arg Ser 
145                 150                 155                 160 


Leu Leu Ile Phe Lys Asp Leu Ala Tyr Ser Glu Tyr Leu His Gly Ile 
                165                 170                 175     


Lys Asp Cys Glu Ile Gln Pro Tyr Asp Thr Ala Val Asn Ala Thr Glu 
            180                 185                 190         


Val Ser Arg Gln Gln Asn Val Ile Glu Glu His Asp Gly Asp Leu Lys 
        195                 200                 205             


Ala Ile His Arg Ser Ile Thr Arg Val Ser Leu Thr Cys Arg Val Val 
    210                 215                 220                 


Ser Lys Val His Lys Asn Leu Phe Arg Phe 
225                 230                 


<210>  253
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  253

Met Tyr Glu Pro Asn Asn Thr Ile Pro Ala Ile Asp Leu Ile Pro Thr 
1               5                   10                  15      


Glu Pro Phe Ser Leu Ile Val Pro Asn Gly Ser Glu Asn Ser Leu Cys 
            20                  25                  30          


Gly Thr Lys Met Lys Lys Asn Asn Thr Leu Lys Thr Ser Tyr Ala Val 
        35                  40                  45              


Leu Arg Pro Gly Met Val His Leu Lys Asn Tyr Ile Ser Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Ile Ile Asn Thr Cys Gln Glu Phe Gly Met Gly Pro Gly 
65                  70                  75                  80  


Gly Phe Tyr Gln Pro Gly Phe Asn Gly Gly Ser Lys Leu Asn Leu His 
                85                  90                  95      


Met Met Cys Phe Gly Arg Asn Trp Asp Pro Gln Thr Lys Tyr Val Ala 
            100                 105                 110         


Arg Tyr Arg Cys Asp Gly Ser Gln Ala Pro Pro Ile Pro Asp Lys Leu 
        115                 120                 125             


Val Ala Leu Ala Lys Ala Ser Ile Glu Asp Ser Gln Arg His Asp Asn 
    130                 135                 140                 


Val Pro Ser Met His Pro Asp Ile Cys Ile Val Asn Phe Tyr Thr Asn 
145                 150                 155                 160 


Thr Gly Arg Leu Gly Leu His Gln Asp Arg Asp Glu Ser Ser Asn Ser 
                165                 170                 175     


Leu Arg Lys Gly Leu Pro Val Val Ser Ile Ser Val Gly Asp Ser Ala 
            180                 185                 190         


Gln Phe Leu Tyr Gly His Ser Arg Asp Met Arg Lys Ala Asn Glu Val 
        195                 200                 205             


Leu Leu Lys Ser Gly Asp Val Leu Ile Phe Gly Gly Lys Ser Arg Asp 
    210                 215                 220                 


Ile Tyr His Gly Val Lys Ala Ile Ile Pro Asn Ser Ala Pro Leu Ser 
225                 230                 235                 240 


Leu Leu Lys Gln Ser Lys Leu Arg Pro Gly Arg Leu Asn Leu Thr Leu 
                245                 250                 255     


Arg Gln Tyr 
            


<210>  254
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  254

Met Ile Pro Pro Leu Cys Pro Leu Arg Trp Ala Pro Leu Gln Thr Ser 
1               5                   10                  15      


Gly Gln Lys Ala Leu Pro Ser Gly Glu Asn Asn Arg Tyr Ser Lys Lys 
            20                  25                  30          


Ala Ile Asn Lys Pro Gln Glu Thr Gly Lys Ser Ala Gly Phe Gly Val 
        35                  40                  45              


His Phe Pro Leu Val Pro Lys Pro Val Asn Arg Gly Met Gly Lys Lys 
    50                  55                  60                  


Glu Ile Leu Leu Pro Leu Trp Gly Val Ala Glu Ala Pro Leu Val Thr 
65                  70                  75                  80  


Glu Arg Glu Arg Val Tyr Val Thr Thr Phe Glu Gln Pro Glu Ile Thr 
                85                  90                  95      


Leu Ile Thr His Lys Asp Glu Phe Cys Val Leu Val Gln Glu Val Asp 
            100                 105                 110         


Asp Ala Asp His Ala Met Tyr Glu Pro Asn His Lys Thr Leu Ala Asn 
        115                 120                 125             


Asp Leu Asn Gln Thr Asn Ser Phe Glu Ser Thr Asp Phe Leu Ser Gly 
    130                 135                 140                 


Ile Lys Leu Lys Lys Lys Asp Leu Lys Thr Leu Gly Pro Gly Met Val 
145                 150                 155                 160 


Leu Leu Lys Asn Phe Ile Ser Ile Ser Gly Gln Val Glu Ile Val Lys 
                165                 170                 175     


Thr Cys Gln Glu Phe Gly Lys Gly Pro Gly Gly Phe Tyr Gln Pro Ala 
            180                 185                 190         


Leu Leu Asn Leu Arg Leu Met Cys Phe Gly Arg Asn Trp Asp Pro Gln 
        195                 200                 205             


Thr Lys Tyr Asn Ala Arg Tyr Arg Gly Asp Gly Ser Glu Ala Pro Pro 
    210                 215                 220                 


Ile Pro Asp Lys Leu Val Ser Leu Val Gln Thr Ser Ile Lys Asp Ser 
225                 230                 235                 240 


Gln Ala Tyr Asp Ser Ser Ile Pro Ser Met Asn Pro Asp Ile Cys Ile 
                245                 250                 255     


Val Asn Phe Tyr Ala Thr Ser Gly Arg Leu Gly Leu His Lys Asp Ile 
            260                 265                 270         


Asp Glu Ser Pro Asp Ser Leu Asn Lys Gly Leu Pro Val Val Ser Ile 
        275                 280                 285             


Ser Val Glu Ile Val Lys Thr Cys Gln Glu Phe Gly Lys Gly Pro Gly 
    290                 295                 300                 


Gly Phe Tyr Gln Pro Ala Leu Leu Asn Leu Arg Leu Met Cys Phe Gly 
305                 310                 315                 320 


Arg Asn Trp Asp Pro Gln Thr Lys Tyr Asn Ala Arg Tyr Arg Gly Asp 
                325                 330                 335     


Gly Ser Lys Ala Pro Pro Ile Pro Asp Lys Leu Val Ser Leu Val Gln 
            340                 345                 350         


Thr Ser Ile Lys Asp Ser Gln Ala Tyr Asp Ser Ser Ile Pro Ser Met 
        355                 360                 365             


Asn Pro Asp Ile Cys Ile Val Asn Phe Tyr Ala Thr Ser Gly Arg Leu 
    370                 375                 380                 


Gly Leu His Lys Asp Ile Asp Glu Ser Pro Asp Ser Leu Asn Lys Gly 
385                 390                 395                 400 


Leu Pro Val Val Ser Ile Ser Val Gly Asp Ser Ala Lys Phe Leu Tyr 
                405                 410                 415     


Gly Arg Tyr Arg Asp Glu Arg Lys Ala Asn Glu Val Leu Leu Lys Ser 
            420                 425                 430         


Gly Asp Val Leu Ile Phe Gly Gly Arg Ser Arg Arg Ile Tyr His Gly 
        435                 440                 445             


Val Lys Thr Ile Ile Pro Asn Ser Ala Pro Leu Pro Leu Gln Glu Ile 
    450                 455                 460                 


Met Leu Gly Pro Gly Arg Phe Asn Leu Thr Phe Arg Gln Phe 
465                 470                 475             


<210>  255
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  255

Met Tyr Lys Pro Asn Asn Met Ile Pro Ala Ile Asp Ser Ile Pro Thr 
1               5                   10                  15      


Lys Pro Phe Ser Leu Ile Leu Pro Glu Lys Ser Thr Asn Ser Leu Ser 
            20                  25                  30          


Glu Ile Glu Met Lys Lys Asp Tyr Asn Leu Lys Ser Ser Cys Val Val 
        35                  40                  45              


Leu Lys Pro Gly Met Val Leu Leu Lys Asn Tyr Ile Ser Ile Thr Asp 
    50                  55                  60                  


Gln Val Glu Ile Val Lys Ile Cys Gln Glu Phe Gly Met Gly Pro Gly 
65                  70                  75                  80  


Gly Phe Tyr Gln Pro Gly Leu Asn Ser Gly Ala Lys Leu Asn Leu His 
                85                  90                  95      


Met Met Cys Phe Gly Arg Asn Trp Asp Pro Gln Thr Lys Tyr Ala Ala 
            100                 105                 110         


Arg Tyr Arg Tyr Asp Gly Ser Gln Ala Pro Pro Val His Asp Lys Leu 
        115                 120                 125             


Val Ser Leu Ala Lys Thr Ser Ile Lys Asp Ser Gln Ala His Asp Asp 
    130                 135                 140                 


Lys Ile Pro Ser Met His Pro Asp Ile Cys Ile Val Asn Phe Tyr Thr 
145                 150                 155                 160 


Ala Thr Gly Arg Leu Gly Met His Gln Asp Arg Asp Glu Ser Ser Asp 
                165                 170                 175     


Ser Leu Arg Lys Gly Leu Pro Val Val Ser Ile Ser Val Gly Asp Ser 
            180                 185                 190         


Ala Gln Phe Leu Tyr Gly His Asn Arg Asp Val Arg Lys Ala Asn Glu 
        195                 200                 205             


Val Leu Leu Glu Ser Gly Asp Val Val Val Phe Gly Gly Lys Ser Arg 
    210                 215                 220                 


Asn Val Tyr His Gly Val Lys Thr Ile Ile Pro Asn Ser Ala Pro Leu 
225                 230                 235                 240 


Pro Leu Leu Gln Gln Ser Lys Leu Arg Pro Gly Arg Leu Asn Leu Thr 
                245                 250                 255     


Phe Arg Gln Phe 
            260 


<210>  256
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  256

Met Met Lys Arg Ile Gln Glu Met Met Lys Pro His Ser Leu Met Leu 
1               5                   10                  15      


Val Arg Tyr Ala Ser Tyr Lys Pro Asn His Lys Thr Pro Val Asn Asp 
            20                  25                  30          


Leu Asn Gln Thr Lys Thr Phe Ser Leu Thr Asn Leu Arg Ser Thr Thr 
        35                  40                  45              


Ser Leu Cys Gly Ile Asp Met Pro Glu Asp Leu Glu Ser Ser Cys Ala 
    50                  55                  60                  


Ile Leu Gly Pro Gly Met Val Leu Leu Lys Asn Tyr Ile Asn Ile Asn 
65                  70                  75                  80  


Asp Gln Ala Glu Ile Val Asn Thr Cys Gln Glu Phe Gly Met Gly Pro 
                85                  90                  95      


Gln Gly Phe Tyr Gln Pro Ser Tyr Lys Gly Gly Ala Lys Leu Asn Leu 
            100                 105                 110         


His Met Met Cys Phe Gly Arg Asn Trp Asp Pro Gln Thr Lys Tyr Asp 
        115                 120                 125             


Pro Tyr Tyr Arg Ser Asp Gly Phe Gln Ala Pro Pro Val Pro Asp Gln 
    130                 135                 140                 


Leu Ile Ser Leu Val Glu Ser Ser Ile Gln Asp Ser Gln Ala His Asp 
145                 150                 155                 160 


Asp Glu Ile Pro Ser Met Tyr Pro Asp Ile Cys Ile Val Asn Phe Tyr 
                165                 170                 175     


Thr Thr Thr Gly Arg Leu Gly Leu His Gln Asp Arg Asp Glu Ser Gln 
            180                 185                 190         


Ser Ser Arg Asn Arg Gly Leu Pro Val Val Ser Ile Ser Ile Gly Asp 
        195                 200                 205             


Ser Ala Gln Phe Val Tyr Gly Asp Ser Arg Asp Val Glu Met Ala Asn 
    210                 215                 220                 


Glu Val Leu Leu Lys Ser Gly Asp Val Leu Val Phe Gly Gly Lys Ser 
225                 230                 235                 240 


Arg His Val Tyr His Ala Val Lys Lys Ile Ile Pro Asn Ser Ala Pro 
                245                 250                 255     


Leu Pro Leu Leu Gln Gln Ser Met Leu Arg Pro Gly Arg Leu Asn Leu 
            260                 265                 270         


Thr Phe Arg Gln Tyr 
        275         


<210>  257
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  257

Met Ala Lys Gly Ser Leu Pro Gln Lys Gln Glu Lys Lys Lys Glu Val 
1               5                   10                  15      


Gly Ser Gln Leu Val Ser Pro Gln Met Phe Gln Arg Val Asn Leu Pro 
            20                  25                  30          


Ala Ala Met His Leu Phe Glu Trp Lys Tyr Glu Ser Gln Ile Asn Asn 
        35                  40                  45              


Glu Lys Lys Asn Asp Asn Met Glu Lys Phe Met Arg Val His Gln Ala 
    50                  55                  60                  


Leu Pro Gly Ser His Phe Asn Ser Leu Leu Leu Asn Arg Tyr Lys Thr 
65                  70                  75                  80  


Gly Asn His Tyr Val Gly Trp His Ala Asp Asn Glu Thr Leu Tyr Gly 
                85                  90                  95      


Pro Thr Pro Glu Ile Ser Ser Val Ser Phe Gly Cys Glu Cys His Phe 
            100                 105                 110         


Leu Leu Lys Lys Arg Asn Thr Asn Asn Glu Pro Pro Thr Lys Arg Pro 
        115                 120                 125             


Lys Asn Asn Glu Gly Thr Tyr Cys Thr His Lys Cys Cys Phe Thr Leu 
    130                 135                 140                 


Lys His Gly Ser Leu Leu Val Met Arg Gly Asn Thr Gln Arg Asp Trp 
145                 150                 155                 160 


Leu His Ser Val Pro Lys Arg Ala Lys Ala Asn Ser Ala Arg Ile Asn 
                165                 170                 175     


Leu Thr Phe Arg Arg Val Ile Met 
            180                 


<210>  258
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  258

Met Ser Ser Cys Cys Ile Gly Lys Val Leu Asn Glu Tyr Ser Phe Lys 
1               5                   10                  15      


Ile Glu Ser Leu Asn Val Phe Val Leu Lys Ala Leu Ala Arg Ser Leu 
            20                  25                  30          


Asn Leu Glu Glu Asp Cys Phe Met Asn Gln Tyr Gly Lys Thr Ser Lys 
        35                  40                  45              


Ile Asn Ala Arg Phe Asn Tyr Tyr Pro Pro Cys Pro Leu Pro Glu Lys 
    50                  55                  60                  


Val Leu Gly Leu Lys Pro His Gly Asp Gly Ser Ala Ile Thr Phe Leu 
65                  70                  75                  80  


Leu Gln Asp Lys Glu Val Glu Gly Leu Gln Leu Leu Lys Asp Asp Glu 
                85                  90                  95      


Trp Val Gly Val Pro Val Val Ser Asn Ser Leu Thr Ile Asn Ile Gly 
            100                 105                 110         


Asp Gln Met Glu Ile Met Ser Asn Cys Ile Phe Lys Ser Pro Leu His 
        115                 120                 125             


Arg Val Phe Val Asn Ser Lys Asn Glu Arg Met Thr Leu Ala Met Phe 
    130                 135                 140                 


Cys Met Arg Gln Thr Glu Lys Asn Ile Gly Pro Val Asp Gly Leu Ile 
145                 150                 155                 160 


Thr Asp Glu Thr Pro Arg Leu Tyr Lys Asn Ile Thr Phe Thr Leu Asp 
                165                 170                 175     


Phe Met His Lys Asn Tyr Gln Gln Gly Arg Arg Ala Ile Asn Ala Cys 
            180                 185                 190         


Lys Ile 
        


<210>  259
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  259

Met Met Cys Phe Gly Arg Asn Trp Asp Pro Lys Thr Lys Tyr Asp Lys 
1               5                   10                  15      


Gln Tyr Arg Ser Asp Gly Ser Glu Ala Pro Pro Ala Pro Pro Ile Pro 
            20                  25                  30          


Gly Lys Leu Val Ser Leu Val Gln Arg Ser Leu Gln Asp Cys Gln Ala 
        35                  40                  45              


Tyr Glu Asn Ser Arg Asp Glu Phe Pro Ser Ile Asn Pro Asp Ile Cys 
    50                  55                  60                  


Ile Ala Lys Phe Phe Thr Thr Thr Ser Arg Leu Val Met Phe Gln Glu 
65                  70                  75                  80  


Asp Asp His His Ser Glu Asp Ser Val Arg Arg Arg Leu Pro Leu Val 
                85                  90                  95      


Ser Leu Phe Ile Gly Asp Ser Ala Glu Phe Leu His Ser Arg Tyr Tyr 
            100                 105                 110         


Gly Ala Ala Asn Pro Asp Lys Val Leu Leu Glu Ser Gly Asp Val Leu 
        115                 120                 125             


Ile Tyr Asn Gly Tyr Asn Arg Tyr Leu Tyr Tyr Gly Val Lys Arg Ile 
    130                 135                 140                 


Ile Pro Asp Ser Ala Pro Leu Pro Leu Leu Asn Glu Ser Met Leu Arg 
145                 150                 155                 160 


Pro Gly Cys Leu Asn Leu Asn Leu Lys Gln Val 
                165                 170     


<210>  260
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  260

Met Glu Val Arg Met Tyr Ser Pro Val Arg Thr Lys Gly Phe Gly Leu 
1               5                   10                  15      


Ile Phe Gly His His Tyr Leu Glu Val Glu His Phe Lys Lys His Lys 
            20                  25                  30          


Phe Val Tyr Lys Leu Ile Asn Ile Leu Thr Glu Asn Lys Asp Met Val 
        35                  40                  45              


Gly Ile Ile Leu Asn Ile Phe Leu Leu Tyr Lys Pro Ile Val His Tyr 
    50                  55                  60                  


Gly Leu Leu Phe Ser Leu Thr Ile Asn Cys Tyr Glu Thr Ala Leu Ile 
65                  70                  75                  80  


Leu Gly Cys Thr Thr Cys Lys Gln Pro Ile Arg Leu His Lys Thr Leu 
                85                  90                  95      


Val Val Gly Leu Leu Thr Trp Thr Asn Val Asn Leu Cys Gln Lys Leu 
            100                 105                 110         


Ser Phe Asn Val Ser Ala Phe Glu Glu Cys Ile Ser Asn Gly Glu Lys 
        115                 120                 125             


Leu Gly Phe His Lys Met Leu Leu Gly Arg Arg Trp His Tyr Glu Lys 
    130                 135                 140                 


His Ser Phe Thr Ile Thr Val Pro Asp Lys Phe Ile Ser Leu Val Lys 
145                 150                 155                 160 


Ser Ser Ile Gln Asp Cys Gln Ser His Leu Asn Thr Lys Asp Glu Lys 
                165                 170                 175     


Ile Ser Val Cys Ser Asn Asn Cys Val Val Lys Phe Tyr Thr Asn Thr 
            180                 185                 190         


Gly His Leu Thr Gln His Glu Val Gly Glu Asp Asp Phe Trp Tyr Ser 
        195                 200                 205             


Tyr Arg Thr Lys Gly Arg Pro Val Val Ser Met Phe Ile Gly Asp Ser 
    210                 215                 220                 


Ala Glu Phe Phe Cys Ser Asp Ser Arg Asn Val Asn Glu Ala Asp Lys 
225                 230                 235                 240 


Val Trp Leu Glu Ser Gly Asp Val Leu Ile Phe Ser Asn Lys Ser Arg 
                245                 250                 255     


Asp Ile Ser Leu Gly Leu His Arg Ile Ile Pro Asn Ser Ala Pro Leu 
            260                 265                 270         


Pro Phe Leu Glu Glu Ser Met Leu Lys Pro Gly Leu Leu Asn Leu Ser 
        275                 280                 285             


Phe Arg Arg Phe 
    290         


<210>  261
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  261

Met Glu Ala Ser Asp Pro Leu Lys Arg Tyr Lys Val Gly Ser Val Pro 
1               5                   10                  15      


Thr Val Tyr Tyr Ile Pro Asp Phe Ile Ser Asp Thr Asp Gln Thr Gln 
            20                  25                  30          


Leu Leu Asn Lys Ile Tyr Thr Ala Pro Val Ser Lys Trp Lys Ser Leu 
        35                  40                  45              


Lys Asn Arg Arg Leu Gln Asp Trp Gly Gly Ile Val His Gly Lys Gly 
    50                  55                  60                  


Leu Leu Pro Gln Asp Leu Pro Ser Trp Leu Thr Lys Ile Thr Glu Lys 
65                  70                  75                  80  


Ile Ser Glu Glu Ser Ser Leu Tyr Pro Ser Ala Ile Asn His Val Leu 
                85                  90                  95      


Ile Asn Glu Tyr Leu Pro Asn Gln Gly Ile Met Pro His Gln Asp Gly 
            100                 105                 110         


Pro Ala Tyr Phe Pro Val Val Ala Ile Leu Ser Leu Gly Ser Pro Val 
        115                 120                 125             


Val Met Asp Phe Thr Pro His Tyr Leu His Gly Ile Lys Asp Cys Glu 
    130                 135                 140                 


Ile Gln Pro Tyr Asp Thr Ala Val Asn Ala Thr Glu Val Leu Lys Gln 
145                 150                 155                 160 


Gln Ser Ala Val Glu Thr His Asp Glu Asp Leu Lys Ala Ile His Arg 
                165                 170                 175     


Ser Asn Thr Arg Val Ser Leu Thr Cys Arg Val Val Ser Lys Val His 
            180                 185                 190         


Lys Asn Leu Phe Arg Phe 
        195             


<210>  262
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  262

Met Glu Arg Gln Leu Ile Lys Asp Ser Arg Gly Lys Cys Gly Ala Tyr 
1               5                   10                  15      


Leu Ser Leu His Arg Asp Asn Lys Asp Lys Thr Ser Ser Arg Ser Leu 
            20                  25                  30          


Glu Ser Gly Val Val Leu Leu Lys Asn Tyr Val Ser Leu Ser Asp Gln 
        35                  40                  45              


Val Glu Ile Val Asn Ile Cys Gln Glu Leu Cys Leu Gly Arg Arg Gly 
    50                  55                  60                  


Phe Tyr Glu Pro Thr His Ser His Gly Gly Lys Leu Gln Leu His Met 
65                  70                  75                  80  


Met Cys Phe Gly Arg Ser Trp Asp Pro Lys Thr Lys Tyr Gly Lys Gln 
                85                  90                  95      


Tyr Arg Ser Asp Gly Ser Glu Ala Pro Pro Ile Pro Glu Lys Leu Val 
            100                 105                 110         


Ser Leu Val Glu Phe Ser Leu Gln Asn Ser Gln Ala Tyr Val Asp Pro 
        115                 120                 125             


Gly Asp Glu Ile Gly Ser Met His Pro Asp Ile Cys Ile Ala Asn Phe 
    130                 135                 140                 


Cys Thr Thr Thr Gly Pro Leu Gly Ile Tyr Met Ala Ile Thr Thr Ser 
145                 150                 155                 160 


Ile Gly Leu Glu Pro Ile Glu Gln Val Gly Pro Val Pro Asn Tyr 
                165                 170                 175 


<210>  263
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  263

Met Val Ala Leu Arg Trp Ser Met Gly His Gly Tyr Arg Tyr Asp Gly 
1               5                   10                  15      


Ser His Arg Pro Leu Leu Leu Asp His Asn Ser Asn Met Tyr Lys Arg 
            20                  25                  30          


Lys Leu Ser Tyr Leu Ser Lys Ser Leu Arg Lys Gly Lys Ala Ser Lys 
        35                  40                  45              


Lys Phe Gln Gln Tyr Ile Asn Ile Asn Lys Ile Pro Ala Leu Asp Leu 
    50                  55                  60                  


His Lys Glu Lys Pro Phe Ser Leu Ile Leu Pro Arg Ser Thr Ala Ser 
65                  70                  75                  80  


Val Leu Lys Ala Asn Asn Lys Asp Lys Thr Ser Ser Gly Ser Ile Leu 
                85                  90                  95      


Asp Gly Val Val Leu Leu Lys Asn Tyr Ile Ser Leu Ser Asp Gln Gly 
            100                 105                 110         


Tyr Trp Gly Cys Leu Val Thr Arg Asn Ile Glu Cys Met Ser Arg Thr 
        115                 120                 125             


Met Leu Arg Ser Arg Gly Phe Tyr Glu Pro Thr His Ser His Gly Gly 
    130                 135                 140                 


Lys Leu Arg Leu His Met Met Cys Phe Gly Arg Asn Trp Asp Pro Lys 
145                 150                 155                 160 


Thr Lys Tyr Asp Lys Gln Tyr Arg Ser Asp Gly Ser Glu Ala Pro Pro 
                165                 170                 175     


Ala Pro Pro Ile Pro Gly Lys Leu Val Ser Leu Val Glu Arg Ser Leu 
            180                 185                 190         


Gln Asp Cys Gln Ala Tyr Glu Asn Ser Arg Asp Glu Phe Pro Ser Ile 
        195                 200                 205             


Asn Pro Asp Ile Cys Ile Ala Lys Phe Phe Thr Thr Thr Ser Arg Leu 
    210                 215                 220                 


Gly Met Phe Gln Glu Asp Asp His His Ser Glu Asp Ser Val Arg Arg 
225                 230                 235                 240 


Arg Leu Pro Leu Val Ser Leu Phe Ile Gly Asp Ser Ala Glu Phe Leu 
                245                 250                 255     


His Ser Arg Tyr Tyr Gly Ala Ala Asn Pro Asp Lys Val Leu Leu Glu 
            260                 265                 270         


Ser Gly Asp Val Leu Ile Tyr Asn Gly Tyr Asn Arg Tyr Leu Tyr Tyr 
        275                 280                 285             


Gly Val Lys Arg Ile Ile Pro Asp Ser Ala Pro Leu Pro Leu Leu Asn 
    290                 295                 300                 


Glu Thr Met Leu Arg Pro Gly Cys Leu Asn Leu Asn Leu Lys Gln Val 
305                 310                 315                 320 


<210>  264
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  264

Met Phe Ile Phe Lys Thr Met Val Lys Ser Leu Glu Leu Glu Glu Asn 
1               5                   10                  15      


Tyr Phe Ser Lys His Phe Thr Glu Glu Lys Asp Val Leu Gln Gly Arg 
            20                  25                  30          


Phe Ile Leu Tyr Pro Pro Cys Pro Thr Pro Asp Lys Val Phe Gly Leu 
        35                  40                  45              


Lys Ala His Ser Asp Arg Ser Glu Ile Thr Leu Leu Leu Gln Asp Pro 
    50                  55                  60                  


Gly Val Glu Gly Leu Arg Val Leu Asn Asp Gly Lys Arg Cys Met Val 
65                  70                  75                  80  


Pro Val Ile Ala Glu Ala Leu Phe Ile Asn Leu Gly Lys Arg 
                85                  90                  


<210>  265
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  265

Met Lys Tyr Arg Val Ala Asp Pro Ser Glu Ser Thr Met Gly Leu Asp 
1               5                   10                  15      


Ser His Ala Asp Thr Ser Ile Leu Thr Ile Leu His Gln Asn Gly Val 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Thr Lys Asp Glu Thr Trp Val Thr Val Leu 
        35                  40                  45              


Ser Asn Gly Arg Leu His Ala Pro Phe His Arg Val Val Met Asn Ala 
    50                  55                  60                  


Asn Lys Thr Arg Leu Ser Val Gly Leu Phe Ser Met Pro Lys Val Gly 
65                  70                  75                  80  


Ser Ile Val Lys Pro Pro Lys Glu 
                85              


<210>  266
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  266

Met Asn Glu Val Tyr Lys Ala Thr Lys Ser Ile Ile Arg Arg Lys Ile 
1               5                   10                  15      


Gln Leu Met Lys Met Gly Asp Arg Lys Lys Glu Gly Lys Lys Ser Lys 
            20                  25                  30          


Thr Asn Trp Pro Val Val Lys Pro Lys Ser Asn Leu Arg Val Asn Arg 
        35                  40                  45              


Leu Lys Asp Phe Asp Leu Phe Thr Val Lys Asn Cys Leu Thr Pro Ala 
    50                  55                  60                  


Glu Ser Asn Ala Phe Val Lys Ala Ala Glu Thr Ile Gly Phe Val His 
65                  70                  75                  80  


Gln Gly Ser Leu Gly Pro Thr Met Gly Glu Ala Tyr Arg Asp Asn Asp 
                85                  90                  95      


Arg Ile Ala Val Asp Asp Pro Val Leu Ala Asp Met Leu Trp Glu Ser 
            100                 105                 110         


Gly Leu Asn Lys Leu Phe Thr Asp Leu Thr Ile Arg Gly Arg Val Ala 
        115                 120                 125             


Val Gly Leu Asn Pro Asn Ile Arg Leu Tyr Arg Tyr Lys Val Gly Gln 
    130                 135                 140                 


Arg Phe Gly Arg His Ile Asp Glu Ser Val Asp Ile Gly Glu Gly Lys 
145                 150                 155                 160 


Arg Thr His Tyr Thr Leu Leu Ile Tyr Leu Asn Gly Gly Glu Ser Lys 
                165                 170                 175     


Ala Lys Ser Asp Val Asn Gly Ser His Asp Ser Ser Glu Pro Leu Val 
            180                 185                 190         


Gly Gly Glu Thr Val Phe Tyr Gly Ser Arg Asn Ser Leu Val Ala Glu 
        195                 200                 205             


Val Ser Pro Ala Gln Gly Met Ala Leu Phe His Leu His Gly Ala Lys 
    210                 215                 220                 


Cys Met Leu His Glu Ser Arg Asn Val Ala Lys Gly Val Lys Tyr Ile 
225                 230                 235                 240 


Leu Arg Ser Asp Val Val Phe Ala 
                245             


<210>  267
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (328)..(328)
<223>  Xaa can be any naturally occurring amino acid

<400>  267

Met Ala Val Thr Ser Asp Arg Ser Pro Tyr Gly Ala Ser Cys Ser Glu 
1               5                   10                  15      


Lys Asp Lys Ser Pro Leu Asn Glu Lys Ser Ala Val Glu Asp Met Ser 
            20                  25                  30          


Ser Gly Asn Leu Asp Phe Lys Glu Thr Pro Asn Leu Leu Asp Asp Asp 
        35                  40                  45              


Ser Ile Ser Glu Lys Leu Lys Asn Ile Ser His Glu Pro Gln Glu Asn 
    50                  55                  60                  


Lys Arg Tyr Asp Ile Cys Tyr Lys Ser Ala Ser Lys Ala Val Lys Leu 
65                  70                  75                  80  


Lys Pro Ser Leu Ala Val Ile Asn Arg Glu Lys Arg Asn Gln Leu Asn 
                85                  90                  95      


Arg Ser Lys Gln Gly Gln Asn Ile Ile Met Leu Arg Pro Gly Met Val 
            100                 105                 110         


Leu Met Lys Gly Tyr Ile Ser Leu Asn Asp Gln Val Ser Ile Val Lys 
        115                 120                 125             


Lys Cys Arg Glu Leu Gly Leu Ser Asp Gly Gly Phe Tyr Gln Pro Ala 
    130                 135                 140                 


Tyr Arg Glu Gly Thr Lys Leu His Leu Lys Met Met Cys Leu Gly Lys 
145                 150                 155                 160 


Asn Trp Asp Pro Gln Ser Lys Leu Tyr Ser Asp Thr Arg Pro Ile Asp 
                165                 170                 175     


Asn Ala Lys Pro Pro Gly Ile Pro Asp Thr Phe Ser Asp Met Val Lys 
            180                 185                 190         


Lys Ala Ile Arg Asp Ser Asn Ala Tyr Leu Glu Glu Lys Asn Pro Asn 
        195                 200                 205             


Ala Tyr Ala Gly Gln Leu Ile Pro Ser Met Ser Pro Asp Ile Cys Ile 
    210                 215                 220                 


Val Asn Phe Tyr Thr Glu Ser Gly Lys Leu Gly Leu His Gln Asp Lys 
225                 230                 235                 240 


Asp Glu Ser Pro Lys Thr Leu Lys Gln Gly Leu Pro Val Val Ser Phe 
                245                 250                 255     


Ser Ile Gly Asp Ser Ala Glu Phe Leu Tyr Gly Asp Asp Arg Asp Ile 
            260                 265                 270         


Asp Thr Ala Asp Lys Val Ile Leu Glu Ser Gly Asp Val Leu Ile Phe 
        275                 280                 285             


Gly Gly Lys Ser Arg Leu Val Phe His Gly Val Thr Ser Ile Leu Pro 
    290                 295                 300                 


Lys Thr Ala Pro Ile Ser Leu Gln Glu Ala Thr Asp Met Ile Pro Gly 
305                 310                 315                 320 


Arg Leu Asn Leu Thr Phe Arg Xaa Ser Asp Gly Ser Pro Tyr Gly Ala 
                325                 330                 335     


Ser Cys Ser Glu Lys Asp Lys Ser Pro Leu Asn Glu Lys Ser Ala Val 
            340                 345                 350         


Glu Asp Met Ser Ser Gly Asn Leu Asp Phe Lys Glu Thr Pro Asn Leu 
        355                 360                 365             


Leu Asp Asp Asp Ser Ile Ser Glu Lys Leu Lys Asn Ile Ser His Glu 
    370                 375                 380                 


Pro Gln Glu Asn Lys Arg Tyr Asp Ile Cys Tyr Lys Ser Ala Ser Lys 
385                 390                 395                 400 


Ala Val Lys Leu Lys Pro Ser Leu Ala Val Ile Asn Arg Glu Lys Arg 
                405                 410                 415     


Asn Gln Leu Asn Arg Ser Lys Gln Gly Gln Asn Ile Ile Met Leu Arg 
            420                 425                 430         


Pro Gly Met Val Leu Met Lys Gly Tyr Ile Ser Leu Asn Asp Gln Val 
        435                 440                 445             


Ser Ile Val Lys Lys Cys Arg Glu Leu Gly Leu Ser Asp Gly Gly Phe 
    450                 455                 460                 


Tyr Gln Pro Ala Tyr Arg Glu Gly Thr Lys Leu His Leu Lys Met Met 
465                 470                 475                 480 


Cys Leu Gly Lys Asn Trp Asp Pro Gln Thr Lys Leu Tyr Ser Asp Thr 
                485                 490                 495     


Arg Pro Ser Asp Asn Ala Lys Pro Pro Ala Ile Pro Asp Thr Phe Ser 
            500                 505                 510         


Asp Met Val Lys Lys Ala Ile Arg Asp Ser Asn Ala Tyr Leu Glu Glu 
        515                 520                 525             


Lys Asn Pro Asn Ala Tyr Ala Gly Gln Leu Ile Pro Ser Leu Ser Pro 
    530                 535                 540                 


Asp Ile Cys Ile Val Asn Phe Tyr Thr Glu Ser Gly Lys Leu Gly Leu 
545                 550                 555                 560 


His Gln Asp Lys Asp Glu Ser Pro Lys Thr Leu Lys Gln Gly Leu Pro 
                565                 570                 575     


Val Val Ser Phe Ser Ile Gly Asp Ser Ala Glu Phe Leu Tyr Gly Asp 
            580                 585                 590         


Asp Arg Asp Ile Asp Thr Ala Asp Lys Val Ile Leu Glu Ser Gly Asp 
        595                 600                 605             


Val Leu Ile Phe Gly Gly Lys Ser Arg Leu Val Phe His Gly Val Thr 
    610                 615                 620                 


Ser Ile Leu Pro Lys Thr Ala Pro Ile Ser Leu Gln Glu Ala Thr Asp 
625                 630                 635                 640 


Met Ile Pro Gly Arg Leu Asn Leu Thr Phe Arg Arg Val Asp Gly Arg 
                645                 650                 655     


Thr Leu Lys Lys Ile Ile Gly Tyr Cys Asn Lys His Val Thr Asp Lys 
            660                 665                 670         


Asp Asn Lys Glu Ala Leu Glu Ala Phe Asp Tyr Glu Phe Val Glu Tyr 
        675                 680                 685             


Phe Asp Asp Leu Thr Leu Thr His Val Ser Tyr Val Ala Lys Tyr Leu 
    690                 695                 700                 


Asp Ile Lys Ser Leu Gln Glu Leu Cys Asp Val Gly Leu Arg Phe Arg 
705                 710                 715                 720 


Leu Arg Arg Ser Tyr Asn Leu Arg Tyr Ala Asn 
                725                 730     


<210>  268
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  268

Met Gly Leu Pro Lys Phe Thr Arg Pro Lys Gly Gly His Glu Glu Leu 
1               5                   10                  15      


Ser Ser Asn Leu Tyr Val Ala Asn Cys Gly Pro Ala Val Gly Leu Thr 
            20                  25                  30          


Leu Asp Ser Ile Glu Ser Ala Phe Ser Leu Tyr Gly Thr Val Lys Gly 
        35                  40                  45              


Val Tyr Pro Ala Asp Glu Ser Gly Cys Arg Val Ile Val Ser Tyr Asp 
    50                  55                  60                  


Asp Glu Ser Ser Ala Gln Thr Ala Leu Lys Ala Leu Asp Arg Lys Thr 
65                  70                  75                  80  


Cys Ser Asp Leu Gly Gly Arg Ser Leu His Ile Arg Tyr Ser Val Gln 
                85                  90                  95      


Arg Pro Leu Ser Gln Val Val Pro Thr Asp Ser Val Gln Val Ser Leu 
            100                 105                 110         


Glu Ala Ser Glu Met Asn Ile Pro Gly Val Tyr Leu Ile His Asp Phe 
        115                 120                 125             


Ile Ser Ala Gln Glu Glu Glu Gln Leu Leu Ala Ala Val Asp Ala Arg 
    130                 135                 140                 


Pro Trp His Asn Leu Ala Lys Arg Arg Val Gln His Tyr Gly Tyr Glu 
145                 150                 155                 160 


Phe Cys Tyr Asn Ile Arg Asn Val Asp Thr Gln Gln Arg Leu Gly Glu 
                165                 170                 175     


Leu Pro Ser Phe Val Ala Cys Val Leu Asp Lys Val Pro Val Phe Gln 
            180                 185                 190         


Lys Leu Asp Glu Ala Ala Asp Val Ser Leu Asp Gln Leu Thr Val Asn 
        195                 200                 205             


Glu Tyr Pro Ser Gly Val Gly Leu Ser Pro His Ile Asp Thr His Ser 
    210                 215                 220                 


Ala Phe Glu Gly Ser Ile Tyr Ser Leu Ser Leu Ser Gly Pro Cys Ile 
225                 230                 235                 240 


Met Glu Phe Arg Arg Tyr Ser Asn Thr Asn Ala Cys Phe Gly Asp Arg 
                245                 250                 255     


Asp Ala Glu Ser Cys Asp Asn Ser Ser Asn Cys Ile Arg Lys Ala Ile 
            260                 265                 270         


Tyr Leu Pro Pro Arg Ser Met Leu Leu Leu Ser Gly Glu Gly Arg Tyr 
        275                 280                 285             


Ala Trp Gln His Tyr Ile Pro His His Lys Ile Asp Met Val Lys Asp 
    290                 295                 300                 


Thr Ile Ile Arg Arg Gly Ser Arg Arg Val Ser Phe Thr Phe Arg Lys 
305                 310                 315                 320 


Val Arg Lys Gly Pro Cys Gln Cys Asp Tyr Pro Gln Phe Cys Asp Ser 
                325                 330                 335     


Pro Arg 
        


<210>  269
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  269

Met Ser Gly Asn Asn Arg Gln Ser Asn Arg Lys Ser Asp Asn Asn Asn 
1               5                   10                  15      


Asn Asp Asn Asn Lys Ile Lys Gln Thr Tyr Thr Cys Phe Arg Ala Glu 
            20                  25                  30          


Ala Val Pro Leu Pro Lys Ile Ala Ser Asp Gly Ser Pro Tyr Gly Ala 
        35                  40                  45              


Ser Cys Ser Glu Lys Asp Lys Ser Pro Leu Asn Glu Lys Ser Ala Val 
    50                  55                  60                  


Glu Asp Met Ser Ser Gly Asn Leu Asp Phe Lys Glu Thr Pro Asn Leu 
65                  70                  75                  80  


Leu Asp Asp Asp Ser Ile Ser Glu Lys Leu Lys Asn Ile Ser His Glu 
                85                  90                  95      


Pro Gln Glu Asn Lys Arg Tyr Asp Ile Cys Tyr Lys Ser Ala Ser Lys 
            100                 105                 110         


Ala Val Lys Leu Lys Pro Ser Leu Ala Val Ile Asn Arg Glu Lys Arg 
        115                 120                 125             


Asn Gln Leu Asn Arg Ser Lys Gln Gly Gln Asn Ile Ile Met Leu Arg 
    130                 135                 140                 


Pro Gly Met Val Leu Met Lys Gly Tyr Ile Ser Leu Asn Asp Gln Val 
145                 150                 155                 160 


Ser Ile Val Lys Lys Cys Arg Glu Leu Gly Leu Ser Asp Gly Gly Phe 
                165                 170                 175     


Tyr Gln Pro Ala Tyr Arg Glu Gly Thr Lys Leu His Leu Lys Met Met 
            180                 185                 190         


Cys Leu Gly Lys Asn Trp Asp Pro Gln Thr Lys Leu Tyr Ser Asp Thr 
        195                 200                 205             


Arg Pro Ser Asp Asn Ala Lys Pro Pro Ala Ile Pro Asp Thr Phe Ser 
    210                 215                 220                 


Asp Met Val Lys Lys Ala Ile Arg Asp Ser Asn Ala Tyr Leu Glu Glu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Tyr Ala Gly Gln Leu Ile Pro Ser Leu Ser Pro 
                245                 250                 255     


Asp Ile Cys Ile Val Asn Phe Tyr Thr Glu Ser Gly Lys Leu Gly Leu 
            260                 265                 270         


His Gln Asp Lys Asp Glu Ser Pro Lys Thr Leu Lys Gln Gly Leu Pro 
        275                 280                 285             


Val Val Ser Phe Ser Ile Gly Asp Ser Ala Glu Phe Leu Tyr Gly Asp 
    290                 295                 300                 


Asp Arg Asp Ile Asp Thr Ala Asp Lys Val Ile Leu Glu Ser Gly Asp 
305                 310                 315                 320 


Val Leu Ile Phe Gly Gly Lys Ser Arg Leu Val Phe His Gly Val Thr 
                325                 330                 335     


Ser Ile Leu Pro Lys Thr Ala Pro Ile Ser Leu Gln Glu Ala Thr Asp 
            340                 345                 350         


Met Ile Pro Gly Arg Leu Asn Leu Thr Phe Arg Arg Tyr 
        355                 360                 365 


<210>  270
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  270

Met Thr Glu Glu Asn Glu Thr Ile Glu Leu Tyr Asn Leu Asn Tyr Ser 
1               5                   10                  15      


Asp Leu Ile Ala Leu Ser Ser Ser Ala Pro Gln Ala Ser Lys Asn Thr 
            20                  25                  30          


Glu Tyr Leu Gln Ser Val Met Asn Thr Ile Ile Lys Asn Leu Gly Pro 
        35                  40                  45              


Ser Gly Pro Gly Leu Leu Ala Val Thr Gly Phe Pro Asp Ala Ser Asp 
    50                  55                  60                  


Leu Arg Arg Thr Leu Leu Pro Met Ala Arg Lys Leu Ala Leu Leu Asn 
65                  70                  75                  80  


Asn Asp Asp Arg Lys Cys Val Leu Lys Asp His Gly Leu Gly Ser Asp 
                85                  90                  95      


Val Pro Leu Lys Asn Phe Asp Arg Thr Val Ser Pro Phe Ala Met Gln 
            100                 105                 110         


Leu Lys Tyr Asn Arg Asp Leu Asp Val Asn Ser Ile Cys Asn Val Asn 
        115                 120                 125             


Tyr Leu Gly Ile Ser Gly Cys Gly Ser Asp Asp Lys Ser Leu Ser Glu 
    130                 135                 140                 


Phe Lys Asn Leu Gly Asn Val Phe Lys Glu Leu Gly Asn Cys Met Ile 
145                 150                 155                 160 


Asp Val Gly Leu Arg Leu Ala Arg Val Cys Asp Lys Val Ile Gly Gly 
                165                 170                 175     


His Glu Leu Glu Glu Ser Leu Leu Glu Ser Cys Ser Ala Lys Gly Arg 
            180                 185                 190         


Leu Ile His Tyr His Ser Val Leu Asp Asn Leu Ile Leu Gln Ala Leu 
        195                 200                 205             


Asn Gly Thr Pro Ser Lys Ser Lys Leu Ala Lys Lys Thr Ser Ser Asn 
    210                 215                 220                 


Gln Ser Asp Leu Trp Gln Gln Trp His Tyr Asp Tyr Gly Val Phe Thr 
225                 230                 235                 240 


Ile Leu Thr Asp Pro Met Phe Met Phe Ala Ser Glu Ser Asn Gly Val 
                245                 250                 255     


Ser Leu Ser Tyr Asp Glu Lys Glu Cys Pro Ser Pro Ser Gly His Thr 
            260                 265                 270         


Tyr Leu Lys Ile Leu Asp Pro Asn Thr Asn Ser Val Val Lys Val Lys 
        275                 280                 285             


Ala Ser Ser Gly Ser Phe Ile Val Gln Val Gly Glu Ser Ala Asp Ile 
    290                 295                 300                 


Leu Ser Lys Gly Lys Leu Arg Ala Thr Leu His Ser Val Cys Arg Pro 
305                 310                 315                 320 


Lys Asn Leu Glu Asn Leu Ser Arg Glu Thr Phe Val Val Phe Leu Gln 
                325                 330                 335     


Pro Ala Trp Ser Lys Thr Leu Ser Leu Tyr Asp Phe Ser Met Lys Ser 
            340                 345                 350         


Ser Ser Leu Asn Asp Glu Tyr Ser Arg Lys Arg Asp Glu Glu Asn Gln 
        355                 360                 365             


Ser Gln Asn Pro Ser Ser Asp Ile Gly Lys Leu Val Pro Pro Leu Cys 
    370                 375                 380                 


Asp Arg Leu Lys Asp Gly Met Thr Phe Ala Glu Phe Ser Arg Glu Thr 
385                 390                 395                 400 


Thr Lys Gln Tyr Tyr Gly Ser Ser Gly Leu Gln Thr Lys Arg 
                405                 410                 


<210>  271
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  271

Met Ser Ser Gly Asn Leu Asp Phe Lys Glu Thr Pro Asn Leu Leu Asp 
1               5                   10                  15      


Asp Asp Ser Ile Ser Glu Lys Leu Lys Asn Ile Ser His Glu Pro Gln 
            20                  25                  30          


Glu Asn Lys Arg Tyr Asp Ile Cys Tyr Lys Ser Ala Ser Lys Ala Val 
        35                  40                  45              


Lys Leu Lys Pro Ser Leu Ala Val Ile Asn Arg Glu Lys Arg Asn Gln 
    50                  55                  60                  


Leu Asn Arg Ser Lys Gln Gly Gln Asn Ile Ile Met Leu Arg Pro Gly 
65                  70                  75                  80  


Met Val Leu Met Lys Gly Tyr Ile Ser Leu Asn Asp Gln Val Ser Ile 
                85                  90                  95      


Val Lys Lys Cys Arg Glu Leu Gly Leu Ser Asp Gly Gly Phe Tyr Gln 
            100                 105                 110         


Pro Ala Tyr Arg Glu Gly Thr Lys Leu His Leu Lys Met Met Cys Leu 
        115                 120                 125             


Gly Lys Asn Trp Asp Pro Gln Thr Lys Leu Tyr Ser Asp Thr Arg Pro 
    130                 135                 140                 


Ser Asp Asn Ala Lys Pro Pro Ala Ile Pro Asp Thr Phe Ser Asp Met 
145                 150                 155                 160 


Val Lys Lys Ala Ile Arg Asp Ser Asn Ala Tyr Leu Glu Glu Lys Asn 
                165                 170                 175     


Pro Asn Ala Tyr Ala Gly Gln Leu Ile Pro Ser Leu Ser Pro Asp Ile 
            180                 185                 190         


Cys Ile Val Asn Phe Tyr Thr Glu Ser Gly Lys Leu Gly Leu His Gln 
        195                 200                 205             


Asp Lys Asp Glu Ser Pro Lys Thr Leu Lys Gln Gly Leu Pro Val Val 
    210                 215                 220                 


Ser Phe Ser Ile Gly Asp Ser Ala Glu Phe Leu Tyr Gly Asp Asp Arg 
225                 230                 235                 240 


Asp Ile Asp Thr Ala Asp Lys Val Ile Leu Glu Ser Gly Asp Val Leu 
                245                 250                 255     


Ile Phe Gly Gly Lys Ser Arg Leu Val Phe His Gly Val Thr Ser Ile 
            260                 265                 270         


Leu Pro Lys Thr Ala Pro Ile Ser Leu Gln Glu Ala Thr Asp Met Ile 
        275                 280                 285             


Pro Gly Arg Leu Asn Leu Thr Phe Arg Arg Tyr 
    290                 295                 


<210>  272
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  272

Met Cys Gln Gln Gly Val Asn Lys Gly Phe Leu Gln Gly Ala Arg Gly 
1               5                   10                  15      


Leu Val Cys Glu Thr Leu Gly Leu Glu Lys Met Asp Glu Lys Val Asn 
            20                  25                  30          


Asp Leu Gln Leu His Lys Asp Gly Glu Trp Val Asp Val Pro Ser Met 
        35                  40                  45              


Arg His Ser Ile Ile Ile Asn Leu Gly Asp Gln Ile Glu Val Met Met 
    50                  55                  60                  


Asp Ser Glu Phe Asp Asp Glu Gly Asn Met His Ser Phe Val Ala Ile 
65                  70                  75                  80  


Ser Phe Gly Ala Met 
                85  


<210>  273
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  273

Met Thr Glu Glu Asn Glu Thr Ile Glu Leu Tyr Asn Leu Asn Tyr Ser 
1               5                   10                  15      


Asp Leu Ile Ala Leu Ser Ser Pro Asp His Lys Ser Gln His Ser Ser 
            20                  25                  30          


Lys Asn Thr Glu Tyr Leu Gln Ser Val Met Asn Thr Ile Met Lys Asn 
        35                  40                  45              


Leu Gly Pro Ser Gly Pro Gly Leu Leu Ala Val Thr Gly Val Pro Asp 
    50                  55                  60                  


Ala Ser Asp Leu Arg Gln Thr Leu Leu Pro Met Ala Arg Lys Leu Ala 
65                  70                  75                  80  


Leu Leu Asn Asn Asp Asp Arg Lys Arg Val Leu Lys Asp His Gly Leu 
                85                  90                  95      


Gly Ser Asp Val Pro Leu Lys Asn Val Asp Arg Thr Val Ser Pro Phe 
            100                 105                 110         


Ala Met Gln Leu Lys Tyr Asn Arg Asp Leu Asp Val Ser Ser Ile Cys 
        115                 120                 125             


Asn Val Asn Tyr Leu Gly Ile Asn Gly Cys Gly Ser Asp Asp Gly Ser 
    130                 135                 140                 


Leu Ser Glu Phe Lys Asn Leu Gly Asn Val Phe Lys Glu Leu Gly Asn 
145                 150                 155                 160 


Cys Met Ile Asp Val Gly Leu Arg Leu Ala Arg Val Cys Asp Lys Val 
                165                 170                 175     


Ile Gly Gly His Glu Leu Glu Glu Ser Leu Leu Glu Ser Cys Ser Ala 
            180                 185                 190         


Lys Gly Arg Leu Ile His Tyr His Ser Val Leu Asp Asn Leu Ile Leu 
        195                 200                 205             


Gln Ala Leu Asn Ala Thr Ala Ser Lys Ser Lys Ser Ala Lys Lys Thr 
    210                 215                 220                 


Ser Ser Asn Gln Ser Asp Leu Trp Gln Gln Trp His Tyr Asp Tyr Gly 
225                 230                 235                 240 


Val Phe Thr Ile Leu Thr Asp Pro Met Phe Met Phe Ala Ser Glu Ser 
                245                 250                 255     


Asn Gly Val Ser Leu Ser Cys Asp Gly Lys Glu Cys Pro Ser Pro Ser 
            260                 265                 270         


Gly His Thr Tyr Leu Gln Ile Leu Asp Pro Asn Lys Asn Ser Val Val 
        275                 280                 285             


Lys Val Lys Ala Ser Ser Gly Ser Phe Ile Val Gln Val Gly Glu Ser 
    290                 295                 300                 


Ala Asp Ile Leu Ser Lys Gly Lys Leu Arg Ala Thr Leu His Ser Val 
305                 310                 315                 320 


Cys Arg Pro Lys Asn Leu Glu Asn Leu Ser Arg Glu Thr Phe Val Val 
                325                 330                 335     


Phe Leu Gln Pro Ala Trp Ser Lys Thr Leu Ser Leu Tyr Asp Phe Ser 
            340                 345                 350         


Met Gln Ser Leu Ser Leu Asn Asp Glu Tyr Ser Arg Asn His Asp Glu 
        355                 360                 365             


Glu Asn Gln Cys Gln Asn Pro Ser Ser Asp Ile Gly Lys Leu Val Pro 
    370                 375                 380                 


Pro Leu Cys Asp Arg Leu Lys Asp Gly Met Thr Phe Ala Glu Phe Ser 
385                 390                 395                 400 


Arg Glu Thr Thr Lys Gln Tyr Tyr Gly Ser Ser Gly Leu Gln Thr Lys 
                405                 410                 415     


Arg 
    


<210>  274
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  274

Met Glu Ile Pro Val Ile Asp Leu Thr Pro Tyr Val Asp Ala Val Ser 
1               5                   10                  15      


Gly Lys Phe Thr Cys Asp Glu His Leu His Pro Glu Leu Lys Ser Val 
            20                  25                  30          


Cys Leu Glu Val Ser Arg Ile Leu Lys Glu Thr Gly Ala Leu Leu Val 
        35                  40                  45              


Arg Asp Pro Arg Cys Ser Thr Glu Asp Asn Asp Arg Phe Ile Asp Met 
    50                  55                  60                  


Met Glu Lys Tyr Phe Glu Gln Pro Glu Glu Val Lys Arg Val Gln Glu 
65                  70                  75                  80  


Arg Pro His Gln His Tyr Gln Val Gly Ser Thr Pro Gly Gly Val Glu 
                85                  90                  95      


Ile Pro Arg Ser Leu Val Asp Leu Glu Met Gln Lys Arg Leu Arg Ala 
            100                 105                 110         


Leu Pro Lys Asp Arg Gln Pro Lys Ile Pro Thr Gly Pro Asp Leu Lys 
        115                 120                 125             


Ser Arg Tyr Met Trp Arg Val Gly Pro Arg Pro Ser Lys Thr Arg Phe 
    130                 135                 140                 


Gln Glu Leu Asn Ser Glu Pro Val Ile Pro Glu Gly Phe Pro Glu Trp 
145                 150                 155                 160 


Lys Lys Ile Met Asp Ser Trp Gly Phe Lys Met Ile Ser Thr Val Glu 
                165                 170                 175     


Ala Val Ala Glu Met Ala Ala Ile Gly Phe Gly Leu Pro Lys Asp Ser 
            180                 185                 190         


Phe Thr Asn Leu Met Lys Leu Gly Pro His Leu Leu Ala Pro Thr Gly 
        195                 200                 205             


Ser Asp Leu Gly Ser His Gly Glu Glu Gly Thr Val Phe Ala Gly Tyr 
    210                 215                 220                 


His Tyr Asp Ile Asn Phe Leu Thr Ile His Tyr Lys Ser Lys Phe Pro 
225                 230                 235                 240 


Gly Leu Phe Ile Trp Leu Arg Asn Gly Glu Lys Ile Glu Val Lys Val 
                245                 250                 255     


Pro Asp Gly Cys Leu Leu Ile Gln Ala Gly Lys Gln Leu Glu Trp Met 
            260                 265                 270         


Thr Ala Gly Asp Cys Lys Ala Gly Met His Glu Val Val Val Thr Asp 
        275                 280                 285             


Ser Thr Leu Arg Ala Ile Glu Ala Ala Lys Lys Glu Asn Arg Ser Leu 
    290                 295                 300                 


Trp Arg Val Ser Ser Thr Leu Phe Ser Asn Val Ala Ser Asp Ala Val 
305                 310                 315                 320 


Leu Lys Pro Leu Gly His Phe Ala Lys Ser Pro Leu Ala Glu Asn Tyr 
                325                 330                 335     


Pro Pro Met Leu Ala Gly Asp Tyr Phe Glu Lys Glu Leu Ser Val Ile 
            340                 345                 350         


Asn Leu Lys Gly Lys Asp Gly Ala 
        355                 360 


<210>  275
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  275

Met Gly Phe Arg Val Leu Leu Met Phe Asn Leu Leu Leu Ile Leu Phe 
1               5                   10                  15      


Leu Ser Asn Leu Ser Ile Lys Ala Ser Ser Leu Arg Lys Ile Arg Glu 
            20                  25                  30          


Ser Val Ile Arg Leu Pro Asn Gly Asp Ser Tyr Gly His Pro Phe Asp 
        35                  40                  45              


Pro Thr Arg Val Thr Gln Ile Ser Trp His Pro Arg Ala Phe Leu Tyr 
    50                  55                  60                  


Arg Asn Phe Leu Thr Asp Gln Glu Cys Asp His Phe Ile Gln Leu Ala 
65                  70                  75                  80  


Lys Asp Lys Leu Glu Lys Ser Met Val Ala Asp Asn Glu Ser Gly Lys 
                85                  90                  95      


Ser Ile Glu Ser Glu Val Arg Thr Ser Ser Gly Met Phe Leu Asn Lys 
            100                 105                 110         


Ala Gln Asp Glu Val Val Ala Gly Val Glu Ala Arg Ile Ser Ala Trp 
        115                 120                 125             


Thr Phe Leu Pro Val Glu Asn Gly Glu Ser Met Gln Ile Leu His Tyr 
    130                 135                 140                 


Glu Asn Gly Gln Lys Tyr Glu Pro His Trp Asp Tyr Phe His Asp Lys 
145                 150                 155                 160 


Ala Asn Gln Ala Leu Gly Gly His Arg Ile Ala Thr Val Leu Met Tyr 
                165                 170                 175     


Leu Ser Asn Val Gln Lys Gly Gly Glu Thr Val Phe Pro Glu Ser Glu 
            180                 185                 190         


Ile Lys Glu Ser Gln Pro Lys Ala Asn Glu Asp Trp Ser Glu Cys Ala 
        195                 200                 205             


Lys Lys Gly Tyr Ala Val Lys Pro Lys Lys Gly Asp Ala Leu Leu Phe 
    210                 215                 220                 


Phe Ser Leu His Pro Asn Ala Thr Thr Asp Val Leu Ser Leu His Gly 
225                 230                 235                 240 


Ser Cys Pro Val Ile Glu Gly Glu Lys Trp Ser Ala Thr Lys Trp Ile 
                245                 250                 255     


His Val Arg Asn Phe Asp Lys Pro Asp Asp Thr Ser Asp Glu Cys Lys 
            260                 265                 270         


Asp Glu Asn Val Asn Cys Ala Thr Trp Ala Ala Ser Gly Glu Cys Ile 
        275                 280                 285             


Lys Asn Pro Val Tyr Met Val Gly Ser Ala Glu Gly Leu Gly Tyr Cys 
    290                 295                 300                 


Arg Lys Ser Cys Lys Val Cys 
305                 310     


<210>  276
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  276

Met Asn Asn Leu Cys Leu Leu Val Leu Ile Ser Leu Leu Phe Ile Val 
1               5                   10                  15      


Pro Arg Ser Ser Cys Ser Ser Ile Ile Asn Pro Ser Lys Val Lys Gln 
            20                  25                  30          


Val Ser Trp Lys Pro Arg Ala Phe Val Tyr Glu Gly Phe Leu Thr Glu 
        35                  40                  45              


Glu Glu Cys Asp His Leu Val Ser Leu Ala Lys Ser Glu Leu Lys Arg 
    50                  55                  60                  


Ser Ala Val Ala Asp Asn Val Ser Gly Lys Ser Gln Leu Ser Glu Val 
65                  70                  75                  80  


Arg Thr Ser Ser Gly Met Phe Ile His Lys Asn Lys Asp Pro Ile Val 
                85                  90                  95      


Ala Gly Ile Glu Glu Lys Ile Ala Thr Trp Thr Phe Leu Pro Lys Glu 
            100                 105                 110         


Asn Gly Glu Asp Ile Gln Val Leu Lys Tyr Glu Ser Gly Gln Lys Tyr 
        115                 120                 125             


Asp Pro His Phe Asp Tyr Phe Ser Asp Pro Val Asn Val Ala Arg Gly 
    130                 135                 140                 


Gly His Arg Ile Ala Thr Val Leu Met Tyr Leu Ser Asp Val Glu Lys 
145                 150                 155                 160 


Gly Gly Glu Thr Val Phe Pro Ser Ala Glu Glu Asn Ser Arg His Lys 
                165                 170                 175     


Thr Pro Lys Pro Asp Asp Leu Ser Glu Cys Ala Lys Lys Gly Ile Ala 
            180                 185                 190         


Val Leu Ile Ser Leu Leu Phe Ile Val Pro Arg Ser Ser Cys Ser Ser 
        195                 200                 205             


Ile Ile Asn Pro Ser Lys Val Lys Gln Val Ser Trp Lys Pro Arg Ala 
    210                 215                 220                 


Phe Val Tyr Glu Gly Phe Leu Thr Glu Glu Glu Cys Asp His Leu Val 
225                 230                 235                 240 


Ser Leu Ala Lys Thr Glu Leu Lys Arg Ser Ala Val Ala Asp Asn Val 
                245                 250                 255     


Ser Gly Lys Ser Gln Leu Ser Glu Val Arg Thr Ser Ser Gly Met Phe 
            260                 265                 270         


Ile Asn Lys Asn Lys Asp Pro Ile Val Ala Gly Ile Glu Glu Lys Ile 
        275                 280                 285             


Ala Thr Trp Thr Phe Leu Pro Lys Glu Asn Gly Glu Asp Ile Gln Val 
    290                 295                 300                 


Leu Lys Tyr Glu Ser Gly Gln Lys Tyr Asp Pro His Phe Asp Tyr Phe 
305                 310                 315                 320 


Ser Asp Pro Val Asn Val Ala Arg Gly Gly His Arg Ile Ala Thr Val 
                325                 330                 335     


Leu Met Tyr Leu Ser Asp Val Glu Lys Gly Gly Glu Thr Val Phe Pro 
            340                 345                 350         


Ser Ala Glu Glu Asn Ser Arg His Lys Thr Pro Lys Pro Asp Asp Leu 
        355                 360                 365             


Ser Glu Cys Ala Lys Lys Gly Ile Ala Val Lys Pro Lys Lys Gly Asp 
    370                 375                 380                 


Ala Leu Leu Phe Phe Ser Leu Tyr Pro Thr Ala Val Pro Asp Thr Met 
385                 390                 395                 400 


Ser Leu His Gly Gly Cys Pro Val Leu Glu Gly Glu Lys Trp Ser Ala 
                405                 410                 415     


Thr Lys Trp Ile His Val Asp Ser Phe Asp Lys Ile Ile Asp Asn Gly 
            420                 425                 430         


Gly Ser Cys Lys Asp Glu Asn Glu Asn Cys Glu Arg Trp Ala Ala Leu 
        435                 440                 445             


Gly Glu Cys Thr Lys Asn Lys Glu Tyr Met Val Gly Thr Pro Glu Leu 
    450                 455                 460                 


Pro Gly Tyr Cys Arg Arg Ser Cys Lys Leu Cys 
465                 470                 475 


<210>  277
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  277

Met Arg Leu Phe Leu Met Leu Ile Val Tyr Ala Tyr Thr Ser Ser Phe 
1               5                   10                  15      


Phe Arg Asp Gln Tyr Asp Arg Val Gly Ile Asn Leu Gly Phe Tyr Ile 
            20                  25                  30          


Thr Ser Leu Arg Thr Ser Val Ile Arg Leu Pro Asn Gly Asp Ser Tyr 
        35                  40                  45              


Gly His Pro Phe Asp Pro Ser Arg Val Ile Arg Ile Ser Trp His Pro 
    50                  55                  60                  


Arg Phe Phe Thr His Ile Val Val Val Tyr Lys Ile Tyr Val Asp Met 
65                  70                  75                  80  


Ala Lys Asp Lys Leu Glu Lys Ser Met Val Ala Asp Val Lys Thr Gly 
                85                  90                  95      


Lys Ser Ile Glu Ser Thr Val Arg Thr Ser Lys Gly Met Phe Ile Arg 
            100                 105                 110         


Lys Ala Gln Asn Arg Asn Glu Ile Ile Ile Val Ser Leu Lys Asp Glu 
        115                 120                 125             


Val Val Gly Arg Ile Glu Ser Arg Ile Ser Val Trp Thr Phe Leu Pro 
    130                 135                 140                 


Val Glu Asn Gly Glu Ala Ile Gln Val Leu His Tyr Glu Asn Gly Gln 
145                 150                 155                 160 


Lys Tyr Leu Pro His Trp Asp Tyr Phe Gln Asp Lys Thr Asn Leu Ala 
                165                 170                 175     


Leu Gly Gly His Arg Ile Val Thr Val Leu Met Tyr Leu Ser Asn Val 
            180                 185                 190         


Glu Lys Gly Gly Glu Thr Ile Phe Pro Glu Ser Glu Val Cys Ser Val 
        195                 200                 205             


Asp Leu Leu Leu Tyr Ala Ile Ser Tyr Val Ser Asn His Val Asp Trp 
    210                 215                 220                 


Phe Leu Asp Asp Leu Gln Met Lys Glu Ser Gln Pro Lys Thr Asp Glu 
225                 230                 235                 240 


Asp Ser Glu Cys Ala Ser Gln Gly Tyr Ala Val Lys Pro Lys Lys Gly 
                245                 250                 255     


Asp Ala Leu Leu Phe Phe Ser Leu His Pro Asn Ala Thr Val Asp Pro 
            260                 265                 270         


Leu Ser Leu His Gly Ser Cys Pro Val Ile Glu Gly Glu Lys Trp Leu 
        275                 280                 285             


Ala Thr Lys Trp Ile His Val Arg Ser Phe Glu Arg Lys Arg Val Ser 
    290                 295                 300                 


Ala Ser Lys Asn Glu Gly Cys Arg Asp Glu His Ile Thr Cys Pro Glu 
305                 310                 315                 320 


Trp Ala Ala His Gly Glu Cys Val Lys Asn Gly Pro Tyr Met Val Gly 
                325                 330                 335     


Ser Ala Asn Ser Pro Gly Lys Cys Arg Lys Ser Cys Lys Val Tyr His 
            340                 345                 350         


Phe Pro Gln Leu Lys Phe Asp Thr Phe Leu Ser Asp Thr Met Val Ile 
        355                 360                 365             


Tyr Thr Ala Ile Glu Tyr Leu Ser 
    370                 375     


<210>  278
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  278

Met Gln Gln Lys Gly Lys Pro Tyr Thr Arg Gly Ala Pro Ser Arg Lys 
1               5                   10                  15      


Pro Ser Ser Ser Ser Ser Ser Thr Leu Ile Phe Ser Ile Leu Ile Ile 
            20                  25                  30          


Cys Leu Phe Phe Ile Leu Ile Leu Leu Ala Leu Gly Ile Leu Ser Ile 
        35                  40                  45              


Pro Asn Thr Ser Ser Ser Lys Asp Leu Thr Ser Ile Leu Gln Arg Leu 
    50                  55                  60                  


Thr Asn Pro Ala Pro Thr Arg Ser Asp Gly Arg Leu Asp Arg Trp Val 
65                  70                  75                  80  


Glu Ile Ile Ser Trp Glu Pro Arg Ala Val Ile Tyr His Asn Phe Leu 
                85                  90                  95      


Ser Gln Glu Glu Cys Glu His Leu Ile Asn Ile Ala Lys Pro His Met 
            100                 105                 110         


Glu Lys Ser Thr Val Val Asp Ser Val Thr Gly Lys Ser Lys Asp Ser 
        115                 120                 125             


Arg Val Arg Thr Ser Ser Gly Thr Phe Leu Asp Arg Gly Gln Asp Glu 
    130                 135                 140                 


Thr Val Arg Ala Ile Glu Lys Arg Ile Ala Asp Phe Thr Phe Leu Pro 
145                 150                 155                 160 


Val Glu His Gly Glu Gly Leu Gln Val Leu His Tyr Glu Val Gly Gln 
                165                 170                 175     


Lys Tyr Glu Pro His Tyr Asp Tyr Phe Leu Asp Asp Tyr Asn Thr Lys 
            180                 185                 190         


Ser Gly Gly Gln Arg Met Ala Thr Val Leu Met Tyr Leu Ser Asp Val 
        195                 200                 205             


Glu Glu Gly Gly Glu Thr Val Phe Pro Ser Ala Lys Gly Asn Phe Ser 
    210                 215                 220                 


Ala Val Pro Trp Trp Asn Glu Leu Ser Glu Cys Gly Lys Glu Gly Leu 
225                 230                 235                 240 


Ser Val Lys Pro Lys Met Gly Asp Ala Leu Leu Phe Trp Ser Met Lys 
                245                 250                 255     


Pro Asp Ala Thr Thr Asp Pro Ser Ser Leu His Gly Gly Cys Pro Val 
            260                 265                 270         


Ile Lys Gly Asn Lys Trp Ser Ser Thr Lys Trp Ile Arg Val Asn Glu 
        275                 280                 285             


Tyr Asp Ala 
    290     


<210>  279
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  279

Met Gln Gln Lys Gly Lys Pro Tyr Thr Arg Gly Ala Pro Ser Arg Lys 
1               5                   10                  15      


Pro Ser Ser Ser Ser Ser Thr Leu Ile Phe Ser Ile Leu Ile Ile Cys 
            20                  25                  30          


Leu Phe Phe Ile Leu Ile Leu Leu Ala Leu Gly Ile Leu Ser Ile Pro 
        35                  40                  45              


Asn Thr Ser Ser Ser Lys Asp Leu Thr Ser Ile Leu Gln Arg Leu Thr 
    50                  55                  60                  


Asn Pro Ala Pro Thr Met Ser Asp Gly Arg Leu Asp Arg Trp Val Glu 
65                  70                  75                  80  


Ile Ile Ser Trp Glu Pro Arg Ala Val Ile Tyr His Asn Phe Leu Ser 
                85                  90                  95      


Gln Glu Glu Cys Glu His Leu Ile Asn Ile Ala Lys Pro His Met Glu 
            100                 105                 110         


Lys Ser Thr Val Val Asp Ser Val Thr Gly Lys Ser Lys Asp Ser Arg 
        115                 120                 125             


Val Arg Thr Ser Ser Gly Thr Phe Leu Asp Arg Gly Gln Asp Glu Thr 
    130                 135                 140                 


Val Arg Ala Ile Glu Lys Arg Ile Ala Asp Phe Thr Phe Leu Pro Val 
145                 150                 155                 160 


Glu His Gly Glu Gly Leu Gln Val Leu His Tyr Glu Val Gly Gln Lys 
                165                 170                 175     


Tyr Glu Pro His Tyr Asp Tyr Phe Leu Asp Asp Tyr Asn Thr Lys Ser 
            180                 185                 190         


Gly Gly Gln Arg Met Ala Thr Val Leu Met Tyr Leu Ser Asp Val Glu 
        195                 200                 205             


Glu Gly Gly Glu Thr Val Phe Pro Ser Ala Lys Gly Asn Phe Ser Ala 
    210                 215                 220                 


Val Pro Trp Trp Asn Glu Leu Ser Glu Cys Gly Lys Glu Gly Leu Ser 
225                 230                 235                 240 


Val Lys Pro Lys Met Gly Asp Ala Leu Leu Phe Trp Ser Met Lys Pro 
                245                 250                 255     


Asp Ala Thr Thr Asp Pro Ser Ser Leu His Gly Gly Cys Pro Val Ile 
            260                 265                 270         


Lys Gly Asn Lys Trp Ser Ser Thr Lys Trp Ile Arg Val Asn Glu Tyr 
        275                 280                 285             


Asp Ala 
    290 


<210>  280
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  280

Met Ser Gly Ala Met Val Trp Ser Ser Tyr Thr Thr Gly Asp Ala Leu 
1               5                   10                  15      


Thr Ile Ile Cys Ser Phe Phe Leu Leu Ala Leu Gly Ile Leu Ser Ile 
            20                  25                  30          


Leu Tyr Lys Ser Ser Asn Ser Pro Lys Ala Asn Asp Pro Ser Ser Thr 
        35                  40                  45              


Val His Arg Thr Val Asp Arg Ser Asp Val Glu Lys Gly Gly Glu Thr 
    50                  55                  60                  


Val Phe Pro Ser Ala Lys Pro Asn Ile Ser Val Val Pro Gly Trp Asn 
65                  70                  75                  80  


Glu Leu Ser Lys Ser Gly Lys Lys Gly Leu Phe Val Lys Pro Thr Met 
                85                  90                  95      


Gly Asp Pro Leu Leu Phe Trp Ser Met Lys Pro Asp Gly Ser Val Asp 
            100                 105                 110         


Pro Leu Ser Leu His Ala Ser Leu Thr Ser Ser Ala Asn Ser Thr Leu 
        115                 120                 125             


Ile Pro Ser Ile Leu Ile Ile Gly Ser Ser Val Leu Leu Thr Leu Gly 
    130                 135                 140                 


Ile Leu Leu Ile Pro Lys Ser Leu Ser Asn Leu Leu Lys Ala His Tyr 
145                 150                 155                 160 


Arg Thr Thr Val Asp Arg Glu Asp Gln Ser Val Glu Val Leu Ser Ser 
                165                 170                 175     


Glu Pro Arg Ala Val Ile Phe His Asn Phe Leu Ser Pro Glu Glu Cys 
            180                 185                 190         


Asp Tyr Leu Ile Ser Leu Ala Lys Pro His Met Ser Arg Ser Thr Val 
        195                 200                 205             


Asn Asp Arg Val Thr Gly Lys Ser Ile Tyr Ser Ser Thr Arg Thr Ser 
    210                 215                 220                 


Ser Ser Met Tyr Leu Ala Arg Glu Arg Gly Lys Met Ile Gln Ser Ile 
225                 230                 235                 240 


Glu Lys Arg Ile Ala Asp Ile Thr Ser Leu Pro Val Glu Asn Gly Glu 
                245                 250                 255     


Gly Leu Ser Ile Ile His Tyr Glu Val Gly Gln Lys Ile Glu Asn His 
            260                 265                 270         


His Asp Tyr Phe Thr Asn Asp Phe Met Ile Lys Asn Gly Gly Gln Arg 
        275                 280                 285             


Leu Ala Thr Val Leu Met Tyr Leu Ser Asp Val Glu Glu Gly Gly Glu 
    290                 295                 300                 


Thr Val Phe Pro Ser Ala Lys Gly Asn Ile Asn Arg Lys Trp Gly Lys 
305                 310                 315                 320 


Lys Gly Leu Ser Val Lys Pro Lys Lys Gly Asp Ala Leu Leu Phe Tyr 
                325                 330                 335     


Ser Met Lys Pro Asp Ala Ser Leu Asp Pro Leu Ser Leu His Gly Gly 
            340                 345                 350         


Arg Pro Val Ile Lys Gly Asp Lys Trp Cys Ala Val Lys Trp Ile Arg 
        355                 360                 365             


Val Asn Lys Tyr Lys Val 
    370                 


<210>  281
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  281

Met Thr Asp Lys Met Asp Gly Gly Asp Gly Ala Arg Ala Cys Gly Ala 
1               5                   10                  15      


Asn Arg Gly Val Gly Leu Glu Leu Leu Phe Gly Ala Ile Gly Trp Gly 
            20                  25                  30          


Glu Leu Asn Leu Ile Gly Leu Gly Cys Ser Ser Asp Gly Ala Ser Asp 
        35                  40                  45              


Gly Met Gly Lys Arg Gly Asp Gln Trp Thr Glu Ile Leu Ser Trp Glu 
    50                  55                  60                  


Pro Arg Ala Phe Val Tyr His Asn Phe Leu Ser Lys Glu Glu Cys Glu 
65                  70                  75                  80  


Tyr Leu Ile Asn Leu Ala Lys Pro His Met Ala Lys Ser Thr Val Val 
                85                  90                  95      


Asp Ser Thr Thr Gly Lys Ser Lys Asp Ser Arg Val Arg Thr Ser Ser 
            100                 105                 110         


Gly Thr Phe Leu Arg Arg Gly Arg Asp Lys Ile Ile Arg Asn Ile Glu 
        115                 120                 125             


Gln Arg Ile Ala Asp Phe Thr Phe Ile Pro Val Glu His Gly Glu Gly 
    130                 135                 140                 


Leu Gln Val Leu His Tyr Glu Glu Gly Gln Lys Tyr Glu Pro His Phe 
145                 150                 155                 160 


Asp Tyr Phe Leu Asp Glu Phe Asn Thr Lys Asn Gly Gly Gln Arg Ile 
                165                 170                 175     


Ala Thr Val Leu Met Tyr Leu Ser Asp Val Glu Glu Gly Gly Glu Thr 
            180                 185                 190         


Val Phe Pro Asp Ala His Gly Asn Tyr Ser Ser Asp Pro Asp Trp Asn 
        195                 200                 205             


Lys Leu Ser Glu Cys Ala Lys Arg Gly Ile His Val Lys Pro Lys Met 
    210                 215                 220                 


Gly Asp Ala Leu Leu Phe Trp Ser Met Arg Pro Asp Ala Thr Leu Asp 
225                 230                 235                 240 


Pro Ser Ser Leu His Ala Tyr Ile Pro Ile Asn Leu Asp Leu Asp Glu 
                245                 250                 255     


Leu Asn Tyr Asp Gln Trp Ser Lys Leu Tyr Asn Thr Thr Ala Lys Ile 
            260                 265                 270         


Leu Val Phe Met Gly Thr Ser Leu Val Pro Gln Lys Pro Arg Val Gln 
        275                 280                 285             


Pro Met Lys Asn Glu Arg Ser Glu Thr Ser Leu Ser Ser Phe Glu Ser 
    290                 295                 300                 


Trp Asn Asp Met Ala Asn Leu Leu Ala Asn Ile Glu Ala Leu Leu Ser 
305                 310                 315                 320 


Asp Lys Ser Leu Val Thr Tyr Ile Val Asn Arg Leu Gly Asn Lys Phe 
                325                 330                 335     


Ala His Ile Ala Ser Ile Ile Arg His His Phe Pro Thr Phe Asp Thr 
            340                 345                 350         


Thr Arg Ser Met Leu Leu Val Glu Glu Ser Ile Val Asn Arg Glu Thr 
        355                 360                 365             


Ser Ser Ser Ser Phe 
    370             


<210>  282
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  282

Met Asn Phe Arg Asn Ser Phe Ile Leu Phe Arg Leu Cys Leu Asn Ile 
1               5                   10                  15      


Leu Ser Pro Asp Phe Thr Leu Leu Ser Ser Gly Ile Pro Asp Ile Arg 
            20                  25                  30          


Thr Ser Val Ile Arg Leu Pro Asn Gly Asp Ser Tyr Gly His Pro Phe 
        35                  40                  45              


Asp Pro Ser Arg Val Ile Arg Ile Ser Trp His Pro Arg Ala Phe Leu 
    50                  55                  60                  


Tyr Lys Lys Phe Leu Thr Asp Glu Glu Cys Asp His Leu Ile Lys Val 
65                  70                  75                  80  


Ala Lys Asp Lys Leu Glu Lys Ser Met Val Ala Asp Val Lys Thr Gly 
                85                  90                  95      


Lys Ser Ile Glu Ser Thr Val Arg Thr Ser Lys Gly Met Ile Ile Arg 
            100                 105                 110         


Lys Ala Gln Asp Glu Val Val Gly Arg Ile Glu Ser Arg Ile Ser Val 
        115                 120                 125             


Trp Thr Phe Leu Pro Val Glu Asn Gly Glu Ala Ile Gln Val Leu His 
    130                 135                 140                 


Tyr Glu Asn Gly Gln Lys Tyr Leu Pro His Trp Asp Tyr Phe Gln Asp 
145                 150                 155                 160 


Lys Pro Asn Gln Ala Leu Gly Gly His Arg Ile Val Thr Val Leu Met 
                165                 170                 175     


Tyr Leu Ser Asn Val Glu Lys Gly Gly Glu Thr Ile Phe Pro Glu Ser 
            180                 185                 190         


Glu Glu Asp Gln Gly His Trp Leu Asn Gly Val Ala Phe Glu Asp Ser 
        195                 200                 205             


Leu Ala Asn Lys His Ile Ala Tyr Leu Lys Asp Glu Gln Lys Asp Glu 
    210                 215                 220                 


Ile Ile Leu Ser Ala Gly Met Ala Asp Asn Pro Met Ser Thr Leu Phe 
225                 230                 235                 240 


Ile Pro Ser Pro Ile Ala Val Asn Pro Ser Gly Val Gln Ile Val Gly 
                245                 250                 255     


Ile Thr Gly Ser Gly Ser Tyr Ile Glu Thr Met Gly Gly Phe Ile Ala 
            260                 265                 270         


Glu Lys Val Asn Gly Pro Leu Ser Met Gly Glu Leu Lys Ile Lys Asn 
        275                 280                 285             


Arg Asn Pro Tyr Asp Asn Pro 
    290                 295 


<210>  283
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  283

Met Thr Glu Thr Glu Gln Ser Ala Ile Leu Asp Ala Leu Pro Gln Thr 
1               5                   10                  15      


Ser Ser Val Lys His Lys Phe Leu Ile Leu Ile Ala Leu Gly Thr Lys 
            20                  25                  30          


Ile Ser Leu Lys Ile Pro Thr Val His Ile Tyr Tyr Phe Met Leu Phe 
        35                  40                  45              


Leu Ile Asp Gly Thr Leu Gln Ser Ile Phe Pro Ser Leu Thr Leu Ile 
    50                  55                  60                  


Leu Ala Val Asn Phe Ile Pro Ile Arg Asn His Met Ser Val Phe Lys 
65                  70                  75                  80  


Ser Gln Asp Glu Cys Asp His Leu Ile Asn Leu Ala Lys Pro His Met 
                85                  90                  95      


Glu Lys Ser Thr Val Val Asp Asn Asp Thr Gly Lys Ser Lys Asp Ser 
            100                 105                 110         


Arg Val Arg Thr Ser Ser Gly Thr Phe Leu Ala Arg Gly Val Asp Glu 
        115                 120                 125             


Thr Val Ala Ala Ile Glu Lys Arg Ile Ala Asp Phe Thr Phe Leu Pro 
    130                 135                 140                 


Val Glu Asn Gly Glu Gly Leu Gln Val Leu His Tyr Glu Val Gly Gln 
145                 150                 155                 160 


Lys Tyr Glu Pro His Tyr Asp Tyr Phe Leu Asp Gln Phe Asn Thr Val 
                165                 170                 175     


Asn Gly Gly Gln Arg Met Ala Thr Val Leu Met Tyr Leu Ser Asp Val 
            180                 185                 190         


Glu Glu Gly Gly Glu Thr Val Phe Pro Ser Ala Lys Gly Asn Ile Ser 
        195                 200                 205             


Ala Val Pro Trp Trp Asn Glu Leu Ser Glu Cys Gly Lys Glu Gly Leu 
    210                 215                 220                 


Ser Val Lys Pro Lys Met Gly Asp Ala Leu Leu Phe Trp Ser Met Arg 
225                 230                 235                 240 


Pro Asp Ala Ser Leu Asp Ser Ser Ser Leu His Gly Gly Cys Pro Val 
                245                 250                 255     


Ile Arg Gly Asn Lys Trp Ser Ser Thr Lys Trp Ile His Val Glu Glu 
            260                 265                 270         


Tyr Lys Val Phe Ala 
        275         


<210>  284
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  284

Met Asp Ser Asn Leu Leu Lys Leu Leu Ile Pro Val Thr Ala Cys His 
1               5                   10                  15      


Ala Leu Gly Arg Val Thr Ser Lys Val Ser Phe Ala Ala Val Ala Val 
            20                  25                  30          


Ser Phe Thr His Thr Ile Lys Asp Leu Glu Pro Phe Phe Asn Ala Ala 
        35                  40                  45              


Ala Ser Gln Phe Ile Leu Gly Gln Leu Ile Pro Ile Thr Leu Trp Leu 
    50                  55                  60                  


Ser Leu Ala Pro Val Val Leu Gly Pro Arg Glu Thr Leu Ser Tyr Asn 
65                  70                  75                  80  


Thr Val Gly Glu Gly Asn Lys Trp Tyr Arg Ser Tyr Gly Gln Glu Ile 
                85                  90                  95      


Tyr Ser Pro Leu Leu Leu Ala Phe Thr Gly Gln Ser Gln Glu Glu Cys 
            100                 105                 110         


Glu Tyr Leu Ile Asn Leu Ala Lys Pro His Met Val Lys Ser Thr Val 
        115                 120                 125             


Val Asp Ser Asp Thr Gly Lys Ser Lys Asp Ser Arg Val Arg Thr Ser 
    130                 135                 140                 


Ser Gly Thr Phe Leu Ala Arg Gly Arg Asp Lys Thr Ile Arg Thr Ile 
145                 150                 155                 160 


Glu Lys Arg Ile Ala Asp Phe Thr Phe Leu Pro Val Glu His Gly Glu 
                165                 170                 175     


Gly Leu Gln Ile Leu His Tyr Glu Val Gly Gln Lys Tyr Glu Pro His 
            180                 185                 190         


Tyr Asp Tyr Phe Gln Asp Asp Phe Asn Thr Lys Asn Gly Gly Gln Arg 
        195                 200                 205             


Met Ala Thr Ile Leu Met Tyr Leu Ser Asp Val Glu Glu Gly Gly Glu 
    210                 215                 220                 


Thr Val Phe Pro Ser Ala Lys Gly Asn Ile Ser Ala Val Pro Trp Trp 
225                 230                 235                 240 


Asn Glu Leu Ser Glu Cys Gly Lys Glu Gly Leu Ser Val Lys Pro Lys 
                245                 250                 255     


Met Gly Asp Ala Leu Leu Phe Trp Ser Met Lys Pro Asp Ala Ser Leu 
            260                 265                 270         


Asp Pro Ser Ser Leu His Gly Gly Cys Pro Val Ile Lys Gly Asn Lys 
        275                 280                 285             


Trp Ser Ser Thr Lys Trp Ile Arg Val Asn Glu Tyr Lys Ala 
    290                 295                 300         


<210>  285
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  285

Met Leu Arg Val Leu Glu Asp Gly Lys Gly Gly Gly His Leu Val Phe 
1               5                   10                  15      


Leu Ile Gly Gly Arg Ile Ser Arg Asn Ser Ile Asp Arg Lys Arg Asn 
            20                  25                  30          


Cys Cys Gln Glu Lys Thr Gly Thr Glu Lys Gln His Gly Val Asn Ile 
        35                  40                  45              


Met Ala Leu Glu Phe Lys Ser Gly Gly Phe Gly Cys Gly Gln Gly Arg 
    50                  55                  60                  


Gly Arg Gln Ser Leu Lys Ser Gln Asp Val Asn Glu Arg Phe Gln Arg 
65                  70                  75                  80  


Asp Ala Met Leu Asp Val Thr Thr Val Glu Asn Leu Ile Arg Val Met 
                85                  90                  95      


Ser Asp Val Glu Lys Gly Gly Glu Thr Val Phe Pro Ser Ala Lys Pro 
            100                 105                 110         


Asn Ile Ser Val Val Pro Gly Trp Asn Glu Leu Ser Lys Ser Gly Lys 
        115                 120                 125             


Lys Gly Leu Phe Val Lys Pro Thr Met Gly Asp Pro Leu Leu Phe Trp 
    130                 135                 140                 


Ser Met Lys Pro Asp Gly Ser Val Asp Pro Leu Ser Leu His Ala Ser 
145                 150                 155                 160 


Leu Thr Ser Ser Ala Asn Ser Thr Leu Ile Pro Phe Ile Leu Ile Ile 
                165                 170                 175     


Gly Ser Ser Val Leu Leu Thr Leu Gly Ile Leu Leu Ile Pro Lys Ser 
            180                 185                 190         


Leu Ser Asn Trp Leu Lys Ala His Tyr Arg Thr Asn Val Asp Arg Glu 
        195                 200                 205             


Asp Gln Ser Val Glu Val Leu Ser Ser Glu Pro Arg Ala Val Ile Phe 
    210                 215                 220                 


His Asn Phe Leu Ser Pro Glu Glu Cys Asp Tyr Leu Ile Ser Leu Ala 
225                 230                 235                 240 


Asn Pro His Met Ser Arg Ser Met Val Ile Asp Ser Val Thr Gly Lys 
                245                 250                 255     


Ser Ile Tyr Ser Ser Thr Arg Thr Ser Ser Ser Met Tyr Leu Ala Arg 
            260                 265                 270         


Gly Arg Asp Lys Met Ile Gln Ser Ile Glu Lys Arg Ile Ala Asn Ile 
        275                 280                 285             


Thr Ser Leu Pro Val Glu His Arg Gly Gly Leu Gln Ile Ile Leu Tyr 
    290                 295                 300                 


Lys Val Gly Gln Met Ile Glu Asn His His Asp Tyr Leu Thr Lys Asp 
305                 310                 315                 320 


Phe Met Ile Lys Asn Gly Gly Gln Arg Leu Ala Thr Val Leu Met Tyr 
                325                 330                 335     


Leu Ser Asp Val Glu Glu Gly Gly Glu Thr Val Phe Pro Ser Ala Lys 
            340                 345                 350         


Gly Asn Val Asn Arg Lys Tyr Gly Lys Asn Gly Leu Ser Ile Lys Pro 
        355                 360                 365             


Lys Lys Gly Asp Ala Leu Leu Phe Tyr Ser Met Lys Pro Asp Ala Ser 
    370                 375                 380                 


Leu Asp Pro Leu Ser Leu His Gly Lys 
385                 390             


<210>  286
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  286

Met Lys Ser Arg Gly Lys Thr Gly Ala Gly Ile Ile Thr Gly Trp Ser 
1               5                   10                  15      


Ser Met Gly Leu Pro Ala Val Phe Leu Leu Cys Ile Phe Phe Phe Phe 
            20                  25                  30          


Leu Gly Phe Phe Gly Ser Ser Leu Phe Ser Gln Gln Val Glu Asn Glu 
        35                  40                  45              


Ser Ala Ser Leu His Ile Thr Arg Pro Arg Pro Arg Met Leu Asn Gln 
    50                  55                  60                  


Asn Glu Tyr Asp Pro Met Pro Gln Gly Asp Ser Gly Asp Asp Tyr Phe 
65                  70                  75                  80  


Thr Thr Ile Pro Phe Gln Ile Leu Ser Trp Lys Pro Arg Ala Leu Tyr 
                85                  90                  95      


Phe Pro Gly Phe Ala Thr Glu Gln Gln Cys Asn Gly Ile Ile Lys Met 
            100                 105                 110         


Ala Lys Val Lys Leu Ala Pro Ser Thr Leu Ala Leu Arg Lys Gly Glu 
        115                 120                 125             


Thr Ala Glu Asn Thr Lys Asp Ile Arg Thr Ser Ser Gly Met Phe Val 
    130                 135                 140                 


Ser Ser Tyr Glu Asp Lys Thr Gly Ile Leu Asp Gln Ile Glu Lys Lys 
145                 150                 155                 160 


Ile Glu Arg Ala Thr Met Ile Pro Arg Arg His Gly Glu Ala Phe Asn 
                165                 170                 175     


Val Leu Arg Tyr Asp Leu Gly Gln Lys Tyr Asn Ser His Tyr Asp Ala 
            180                 185                 190         


Phe Asn Pro Thr Glu Tyr Gly Pro Gln Lys Ser Gln Arg Ile Ala Ser 
        195                 200                 205             


Phe Leu Leu Tyr Leu Ser Asp Val Glu Glu Gly Gly Glu Thr Met Phe 
    210                 215                 220                 


Pro Phe Glu Asn Gly Glu Asn Ala Asp Ser Asn Tyr Asp Phe Arg Lys 
225                 230                 235                 240 


Cys Ile Gly Leu Lys Ile Lys Pro Arg Lys Gly Asp Gly Leu Leu Phe 
                245                 250                 255     


Tyr Ser Leu Tyr Pro Asn Gly Thr Ile Asp Pro Thr Ser Leu His Gly 
            260                 265                 270         


Ser Cys Pro Val Ile Lys Gly Gln Lys Trp Val Ala Thr Lys Trp Leu 
        275                 280                 285             


Arg Asn Glu Glu Asp Phe Asp 
    290                 295 


<210>  287
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  287

Met Ala Ser Ala Met Lys Ile Val Ile Phe Leu Leu Thr Leu Val Thr 
1               5                   10                  15      


Ile Gly Met Ile Phe Gly Ser Leu Leu Gln Leu Ala Phe Ile Arg Asn 
            20                  25                  30          


Leu Glu Asp Ser Tyr Gly Ser Thr Phe Pro Ser Phe Arg Arg Ser Leu 
        35                  40                  45              


Gly Ser Gln Asn Gly Asn Gln Leu Pro Pro Val Ile Ser Gly Trp Gly 
    50                  55                  60                  


Asn Asp Lys Glu Ala Ala Ile Leu Arg Ile Gly Tyr Val Lys Pro Glu 
65                  70                  75                  80  


Ile Ile Ser Trp Ser Pro Arg Ile Ile Val Phe His Asn Phe Leu Ser 
                85                  90                  95      


Ala Glu Glu Cys Asp Tyr Leu Arg Ala Val Ala Lys Pro Arg Leu Lys 
            100                 105                 110         


Val Ser Thr Val Val Asp Ala Lys Thr Gly Lys Gly Ile Lys Ser Asn 
        115                 120                 125             


Val Arg Thr Ser Ser Gly Met Phe Leu Asn His Glu Glu Arg Lys Tyr 
    130                 135                 140                 


Pro Met Val His Ala Ile Glu Lys Arg Ile Ala Thr Tyr Ser Gln Val 
145                 150                 155                 160 


Pro Ile Glu Asn Gly Glu Leu Ile Gln Val Leu Arg Tyr Glu Pro Asn 
                165                 170                 175     


Gln Phe Tyr Arg Pro His His Asp Tyr Phe Ser Asp Thr Phe Asn Leu 
            180                 185                 190         


Lys Arg Gly Gly Gln Arg Val Ala Thr Met Leu Met Tyr Leu Thr Asp 
        195                 200                 205             


Asn Val Glu Gly Gly Glu Thr Phe Phe Pro Leu Ala Gly Ser Glu Glu 
    210                 215                 220                 


Cys Ser Cys Gly Gly Lys Met Val Lys Gly Leu Cys Val Lys Pro Asn 
225                 230                 235                 240 


Lys Gly Asp Ala Val Leu Phe Trp Ser Met Gly Leu Asp Gly Gln Ser 
                245                 250                 255     


Asp Pro Ser Ser Ile His Gly Gly Cys Glu Val Leu Ser Gly Glu Lys 
            260                 265                 270         


Trp Ser Ala Thr Lys Trp Met Arg Gln Lys Ala Thr Ser 
        275                 280                 285 


<210>  288
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  288

Met His Phe Ser Trp Gln Ser Gln Glu Glu Cys Glu Tyr Leu Ile Asn 
1               5                   10                  15      


Leu Ala Lys Pro His Met Val Lys Ser Thr Val Val Asp Ser Asp Thr 
            20                  25                  30          


Gly Lys Ser Lys Asp Ser Arg Val Arg Thr Ser Ser Gly Thr Phe Leu 
        35                  40                  45              


Ala Arg Gly Arg Asp Lys Thr Ile Arg Thr Ile Glu Lys Arg Ile Ala 
    50                  55                  60                  


Asp Phe Thr Phe Leu Pro Val Glu His Gly Glu Gly Leu Gln Ile Leu 
65                  70                  75                  80  


His Tyr Glu Val Gly Gln Lys Tyr Glu Pro His Tyr Asp Tyr Phe Gln 
                85                  90                  95      


Asp Asp Phe Asn Thr Lys Asn Gly Gly Gln Arg Met Ala Thr Ile Leu 
            100                 105                 110         


Met Tyr Leu Ser Asp Val Glu Glu Gly Gly Glu Thr Val Phe Pro Ser 
        115                 120                 125             


Ala Lys Gly Asn Ile Ser Ala Val Pro Trp Trp Asn Glu Leu Ser Glu 
    130                 135                 140                 


Cys Gly Lys Glu Gly Leu Ser Val Lys Pro Lys Met Gly Asp Ala Leu 
145                 150                 155                 160 


Leu Phe Trp Ser Met Lys Pro Asp Ala Ser Leu Asp Pro Ser Ser Leu 
                165                 170                 175     


His Gly Gln Tyr Ile Tyr Pro Ser Met Ser Asp Val Glu Glu Gly Gly 
            180                 185                 190         


Glu Thr Val Phe Pro Ser Ala Lys Gly Asn Ile Ser Ala Val Pro Trp 
        195                 200                 205             


Trp Asn Glu Leu Ser Glu Cys Gly Lys Glu Gly Leu Ser Val Lys Pro 
    210                 215                 220                 


Lys Met Gly Asp Ala Leu Leu Phe Trp Ser Met Lys Pro Asp Ala Ser 
225                 230                 235                 240 


Leu Asp Pro Ser Ser Leu His Gly Gly Cys Pro Val Ile Lys Gly Asn 
                245                 250                 255     


Lys Trp Ser Ser Thr Lys Trp Ile Arg Val Asn Glu Tyr Lys Ala 
            260                 265                 270     


<210>  289
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  289

Met Leu Thr Ser Lys Thr Ser Leu Gln Leu Pro Ile Phe Asp Val Ser 
1               5                   10                  15      


Lys Pro Leu Ser Pro Ser Cys Leu Ser Ser Leu Ser Leu Ala Cys Lys 
            20                  25                  30          


Glu Trp Gly Phe Phe His Ile Ile Asn His Gly Ile Ser Lys Glu Leu 
        35                  40                  45              


Tyr Asn Lys Leu His Phe Leu Ser Asn Gln Leu Phe Asp Leu Pro Tyr 
    50                  55                  60                  


Glu Gln Lys Leu Lys Val Gly Pro Ser Ser Asp Ile Lys Thr Tyr Thr 
65                  70                  75                  80  


Pro His Phe Ile Ala Ser Pro Phe Phe Glu Ser Ile Arg Val Ser Gly 
                85                  90                  95      


Pro Asp Phe Cys Ala Ser Ala Gln Ser Ser Ala Glu Val Leu Leu Asn 
            100                 105                 110         


Gln Ser Lys Thr Glu Phe Ser Glu Val Leu Lys Glu Tyr Gly Ser Ile 
        115                 120                 125             


Met Arg Thr Leu Ser Asn Lys Ile Ile Glu Met Leu Leu Met Cys Leu 
    130                 135                 140                 


Gly Glu Asp Phe Glu Lys Lys Phe Glu Ser Glu Phe Arg Asn Ser Glu 
145                 150                 155                 160 


Gly Tyr Leu Arg Ile Asn Asn Tyr Ser Pro Pro Glu Ser Ile Glu Lys 
                165                 170                 175     


Asp Val Glu Gly Leu Gly Met His Thr Asp Met Ser Cys Ile Thr Ile 
            180                 185                 190         


Val Tyr Gln Asp Lys Ser Gly Gly Leu Gln Val Arg Ser Lys Glu Gly 
        195                 200                 205             


Lys Trp Met Asp Ile Asp Pro Cys Ala Glu Thr Leu Val Val Asn Ile 
    210                 215                 220                 


Gly Asp Leu Met Gln Ala Trp Ser Asn Gly Lys Leu Arg Ser Ser Glu 
225                 230                 235                 240 


His Arg Val Val Leu Lys Glu Arg Lys Asn Arg Phe Ser Leu Ala Phe 
                245                 250                 255     


Phe Trp Cys Phe Glu Asp Asn Lys Val Val Phe Ala Pro Asp Glu Val 
            260                 265                 270         


Val Gly Glu Asn Ser Met Arg Ala Tyr Lys Pro Phe Leu Cys Asp Asp 
        275                 280                 285             


Tyr Met Lys Phe Arg Gln Asn Ser Glu Arg Gly Lys Phe Glu Lys Val 
    290                 295                 300                 


Gly Phe Thr Val Lys Asp Phe Ala Gly Thr Gly Leu Val 
305                 310                 315         


<210>  290
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  290

Met Leu Thr Ser Lys Thr Ser Leu Gln Leu Pro Ile Phe Asp Ile Ser 
1               5                   10                  15      


Lys Pro Leu Ser Pro Ser Cys Leu Ser Ser Leu Ser Leu Ala Cys Lys 
            20                  25                  30          


Glu Trp Gly Phe Phe His Ile Ile Asn His Gly Ile Ser Lys Glu Leu 
        35                  40                  45              


Tyr Asn Lys Leu His Phe Leu Ser Asn Gln Leu Phe Asp Leu Pro Tyr 
    50                  55                  60                  


Glu Gln Lys Leu Lys Val Gly Pro Ser Ser Asp Ile Lys Thr Tyr Thr 
65                  70                  75                  80  


Pro His Phe Ile Ala Ser Pro Phe Phe Glu Ser Ile Arg Val Ser Gly 
                85                  90                  95      


Pro Asp Phe Tyr Ala Ser Ala Gln Ser Ser Ala Glu Val Leu Leu Asn 
            100                 105                 110         


Gln Ser Lys Thr Glu Phe Ser Glu Val Leu Lys Glu Tyr Gly Ser Ile 
        115                 120                 125             


Met Arg Thr Leu Ser Asn Lys Ile Ile Glu Met Leu Leu Met Cys Leu 
    130                 135                 140                 


Gly Glu Asp Phe Glu Lys Lys Phe Glu Ser Glu Phe Lys Asn Ser Glu 
145                 150                 155                 160 


Gly Tyr Leu Arg Ile Asn Asn Tyr Ser Pro Pro Glu Ser Ile Glu Lys 
                165                 170                 175     


Asp Val Glu Gly Leu Gly Met His Thr Asp Met Ser Cys Ile Thr Ile 
            180                 185                 190         


Val Tyr Gln Asp Lys Ser Gly Gly Leu Gln Val Arg Ser Lys Glu Gly 
        195                 200                 205             


Lys Trp Met Asp Ile Asp Pro Cys Ala Glu Thr Leu Val Val Asn Ile 
    210                 215                 220                 


Gly Asp Leu Met Gln Ala Trp Ser Asn Gly Lys Leu Arg Ser Ser Glu 
225                 230                 235                 240 


His Arg Val Val Leu Lys Glu Arg Lys Asn Arg Phe Ser Leu Ala Phe 
                245                 250                 255     


Phe Trp Cys Phe Glu Asp Asn Lys Val Val Phe Ala Pro Asp Glu Val 
            260                 265                 270         


Val Gly Glu Asn Ser Met Arg Ala Tyr Lys Pro Phe Leu Cys Asp Asp 
        275                 280                 285             


Tyr Met Lys Phe Arg Gln Asn Ser Glu Arg Gly Lys Phe Glu Lys Val 
    290                 295                 300                 


Gly Phe Thr Val Lys Asp Phe Ala Gly Thr Gly Leu Val 
305                 310                 315         


<210>  291
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  291

Met Pro Ala Ser Asn Thr Ser Ile Gln Leu Pro Ile Val Asp Ile Ser 
1               5                   10                  15      


Lys Ser Ile Ser Pro Ser Ser Ile Ser Ser Leu Ser Leu Ala Cys Arg 
            20                  25                  30          


Glu Trp Gly Phe Phe His Ile Ile Asn His Gly Ile Ser Lys Asp Leu 
        35                  40                  45              


Tyr Ser Lys Leu Arg Leu Ser Ser Asn Gln Val Phe Asn Leu Pro Tyr 
    50                  55                  60                  


Glu Ala Lys Ile Lys Ala Gly Pro Thr Ser Asn Val Lys Thr Tyr Thr 
65                  70                  75                  80  


Pro His Phe Ile Ala Ser Pro Phe Phe Glu Ser Leu Arg Val Ser Gly 
                85                  90                  95      


Pro Asp Phe Leu Ala Ser Ala Lys Asn Ser Ala Glu Ala Ile Met Asn 
            100                 105                 110         


Gln Pro Asp Thr Glu Phe Ser Glu Val Leu Lys Glu Tyr Gly Asp Lys 
        115                 120                 125             


Met Arg Asn Leu Ser Lys Lys Val Thr Asp Ile Leu Leu Met Cys Leu 
    130                 135                 140                 


Gly Lys Asp Phe Ala Thr Lys Phe Ala Ser Glu Phe Ser Asn Cys Glu 
145                 150                 155                 160 


Gly Tyr Leu Arg Ile Asn Asn Tyr Ser Leu Pro Glu Lys Arg Val Met 
                165                 170                 175     


Glu Lys Glu Val Glu Gly Leu Gly Met His Thr Asp Met Ser Cys Leu 
            180                 185                 190         


Thr Ile Val Tyr Gln Asp Asp Val Gly Gly Leu Gln Val Arg Ser Lys 
        195                 200                 205             


Asp Gly Lys Trp Leu Asp Ile Asn Pro Cys Glu Glu Thr Leu Val Val 
    210                 215                 220                 


Asn Ile Gly Asp Leu Leu His Ala Trp Ser Asn Gly Lys Leu Arg Ser 
225                 230                 235                 240 


Ser Glu His Arg Val Val Leu Lys Glu Cys Lys Thr Arg Phe Ser Leu 
                245                 250                 255     


Ala Phe Phe Trp Cys Phe Glu Asp Asn Lys Val Ile Ser Ala Pro Asn 
            260                 265                 270         


Glu Val Val Gly Asp Glu Phe Arg His Tyr Glu Pro Phe Met Cys Gly 
        275                 280                 285             


Asp Tyr Leu Lys Phe Arg Glu Asn Ser Val Arg Gly Lys Phe Glu Lys 
    290                 295                 300                 


Val Gly Phe Thr Val Lys Asp Phe Ala Gly Ile 
305                 310                 315 


<210>  292
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  292

Met Pro Ala Ser Asn Thr Ser Ile Gln Leu Pro Ile Leu Asp Ile Ser 
1               5                   10                  15      


Lys Ser Ile Ser Pro Ser Ser Ile Ser Ser Leu Ser Leu Ala Cys Arg 
            20                  25                  30          


Glu Trp Gly Phe Phe His Ile Ile Asn His Gly Ile Ser Lys Asp Leu 
        35                  40                  45              


Tyr Ile Lys Leu Arg Leu Ser Ser Asn Gln Val Phe Asn Leu Pro Tyr 
    50                  55                  60                  


Glu Asp Lys Ile Lys Ala Gly Pro Thr Ser Asn Val Lys Thr Tyr Thr 
65                  70                  75                  80  


Pro His Phe Ile Ala Ser Pro Phe Phe Glu Ser Leu Arg Val Ser Gly 
                85                  90                  95      


Pro Asp Phe His Ala Ser Ala Lys Asn Ser Ala Glu Val Ile Met Lys 
            100                 105                 110         


Gln Pro Asp Ile Glu Phe Ser Glu Val Leu Lys Glu Tyr Gly Asp Lys 
        115                 120                 125             


Met Arg Asn Leu Ser Lys Lys Val Thr Glu Ile Leu Leu Met Cys Leu 
    130                 135                 140                 


Gly Lys Asp Phe Val Thr Lys Phe Ala Ser Glu Phe Ser Asn Cys Glu 
145                 150                 155                 160 


Gly Tyr Leu Arg Ile Asn Asn Tyr Ser Leu Pro Glu Lys Arg Val Met 
                165                 170                 175     


Glu Lys Glu Val Glu Gly Leu Gly Lys His Thr Asp Met Ser Cys Leu 
            180                 185                 190         


Thr Ile Val Tyr Gln Asp Asp Val Gly Gly Leu Gln Val Arg Ser Lys 
        195                 200                 205             


Asp Gly Lys Trp Leu Asp Ile Asn Pro Cys Glu Glu Thr Leu Val Val 
    210                 215                 220                 


Asn Ile Gly Asp Leu Leu His Ala Trp Ser Asn Gly Lys Leu Arg Ser 
225                 230                 235                 240 


Ser Glu His Arg Val Val Leu Lys Glu Cys Lys Thr Arg Phe Ser Leu 
                245                 250                 255     


Ala Phe Phe Trp Cys Phe Glu Asp Asn Lys Val Ile Ser Ala Pro Asn 
            260                 265                 270         


Glu Val Val Gly Asp Glu Phe Arg His Tyr Glu Pro Phe Met Cys Gly 
        275                 280                 285             


Asp Tyr Leu Lys Phe Arg Glu Asn Ser Val Arg Gly Lys Phe Glu Lys 
    290                 295                 300                 


Val Gly Phe Thr Val Lys Asp Phe Ala Gly Ile 
305                 310                 315 


<210>  293
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  293

Met Val Ser Asn Ser Cys Phe Glu Thr Thr Leu Asn Leu Pro Ser Ile 
1               5                   10                  15      


Asp Leu Ser Lys Pro Leu Asn Pro Ser Ser Ile Ser Ser Leu Ser Glu 
            20                  25                  30          


Ala Cys His Gln Trp Gly Phe Phe Asn Ile Val Asn His Gly Ile Ser 
        35                  40                  45              


Lys Ser Leu Tyr Glu Asp Ile Arg Ser Phe Ser Asn His Val Phe Asp 
    50                  55                  60                  


Leu Ser Ser Glu Thr Lys Leu Lys Leu Gly Pro Ser Ser Ser Val Lys 
65                  70                  75                  80  


Thr Tyr Thr Pro His Phe Ile Ala Ser Pro Tyr Phe Glu Ser Leu Arg 
                85                  90                  95      


Val Ser Gly Pro Asp Phe His Ser Ser Ala Gln Asp Ser Ile Asp Val 
            100                 105                 110         


Ile Phe His Glu Asp Arg His Glu Phe Ser Glu Ile Leu Glu Glu Tyr 
        115                 120                 125             


Gly Asn Lys Met Thr Glu Leu Ser Lys Lys Ile Met Lys Ile Val Leu 
    130                 135                 140                 


Met Ile Leu Gly Asp Gly Phe Asp Thr Arg Leu Tyr Asp Ser Asp Phe 
145                 150                 155                 160 


Asn Asn Cys His Gly Tyr Leu Arg Ile Asn Arg Tyr Ser Pro Pro Thr 
                165                 170                 175     


Asp Leu Glu Glu Lys Glu Thr Thr Glu Gly Leu Gly Met His Thr Asp 
            180                 185                 190         


Met Ser Cys Ile Thr Ile Val Tyr Gln Asp Glu Thr Gly Gly Leu Gln 
        195                 200                 205             


Val Lys Ser Lys Asp Gly Thr Trp Met Asp Ile Val Pro Ser Glu Gly 
    210                 215                 220                 


Thr Leu Val Val Asn Ile Gly Asp Leu Leu Gln Ala Trp Ser Asn Asp 
225                 230                 235                 240 


Lys Phe Ile Ser Ser Glu His Arg Val Val Leu Lys Lys Pro Val Asn 
                245                 250                 255     


Arg Leu Ser Ile Ala Phe Phe Trp Cys Phe Glu Asp Glu Lys Val Ile 
            260                 265                 270         


Leu Ala Pro Asn Glu Val Val Gly Asn Glu Asn Thr Arg Leu Tyr Glu 
        275                 280                 285             


Pro Phe Val Cys Leu Asp Tyr Leu Lys Phe Arg Glu Ser Asn Glu Glu 
    290                 295                 300                 


Gly Lys Phe Glu Lys Val Gly Phe Thr Val Lys Asp Phe Val Ala His 
305                 310                 315                 320 


Asn Thr Lys Asn Cys Leu Pro Met Pro Val Ser 
                325                 330     


<210>  294
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  294

Met Val Ser Asn Ser Cys Phe Glu Thr Thr Leu Asn Leu Pro Ser Ile 
1               5                   10                  15      


Asp Leu Ser Lys Pro Leu Asn Pro Ser Ser Ile Ser Ser Leu Ser Glu 
            20                  25                  30          


Ala Cys His Gln Trp Gly Phe Phe Asn Ile Val Asn His Gly Ile Ser 
        35                  40                  45              


Lys Ser Leu Tyr Glu Asp Ile Arg Ser Phe Ser Asn His Val Phe Asp 
    50                  55                  60                  


Leu Ser Ser Glu Thr Lys Leu Lys Leu Gly Pro Ser Ser Ser Ile Lys 
65                  70                  75                  80  


Thr Tyr Thr Pro His Phe Ile Ala Ser Pro Tyr Phe Glu Ser Leu Arg 
                85                  90                  95      


Val Ser Gly Pro Asn Phe His Ser Ser Ala Gln Asp Ser Ile Asp Val 
            100                 105                 110         


Ile Phe His Glu Asp Arg His Glu Phe Ser Glu Ile Leu Glu Glu Tyr 
        115                 120                 125             


Gly Asn Lys Met Thr Glu Leu Ser Lys Lys Ile Met Lys Ile Val Leu 
    130                 135                 140                 


Met Ile Leu Gly Asp Gly Phe Asp Thr Arg Leu Tyr Asp Ser Asp Phe 
145                 150                 155                 160 


Asn Asn Cys His Gly Tyr Leu Arg Ile Asn Arg Tyr Ser Pro Pro Thr 
                165                 170                 175     


Asp Leu Glu Glu Lys Glu Thr Thr Glu Gly Leu Gly Met His Thr Asp 
            180                 185                 190         


Met Ser Cys Ile Thr Ile Val Tyr Gln Asp Glu Thr Gly Gly Leu Gln 
        195                 200                 205             


Val Lys Ser Lys Asp Gly Gln Trp Met Asp Ile Val Pro Ser Glu Gly 
    210                 215                 220                 


Thr Leu Val Val Asn Ile Gly Asp Leu Leu Gln Ala Trp Ser Asn Asp 
225                 230                 235                 240 


Lys Phe Ile Ser Ser Glu His Arg Val Val Leu Arg Lys Pro Val Asn 
                245                 250                 255     


Arg Leu Ser Ile Ala Phe Phe Trp Cys Phe Glu Asp Glu Lys Val Ile 
            260                 265                 270         


Leu Ala Pro Asn Glu Val Val Gly Asn Glu Asn Thr Arg Leu Tyr Glu 
        275                 280                 285             


Pro Phe Val Cys Leu Asp Tyr Leu Lys Phe Arg Glu Ser Asn Glu Glu 
    290                 295                 300                 


Gly Lys Phe Glu Lys Val Gly Phe Thr Val Lys Asp Phe Val Ala His 
305                 310                 315                 320 


Asn Thr Lys Asn Cys Leu Pro Met Pro Val Ser 
                325                 330     


<210>  295
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  295

Met Pro Ala Arg Glu Tyr Val Ser Ser Val Gly Asp Met Gly Ser Glu 
1               5                   10                  15      


Thr Pro Thr Lys Leu Pro Cys Ile His Phe Ser Asn Leu Asp Lys His 
            20                  25                  30          


Thr Asn Lys Leu Glu Trp Asp Ser Thr Lys Ser Gln Val His Gln Ala 
        35                  40                  45              


Leu Gln Glu Phe Gly Cys Phe Glu Ala Thr Phe His Asn Ile Pro Pro 
    50                  55                  60                  


Glu Leu Gln Lys Ser Met Phe Glu Ser Leu Gln Leu Leu Phe Asp Leu 
65                  70                  75                  80  


Pro Leu Gln Thr Lys Leu Lys Asn Arg Ser Ser Lys Pro Phe His Gly 
                85                  90                  95      


Tyr Val Gly Gln Tyr Pro Met Val Pro Leu Tyr Glu Ser Met Gly Ile 
            100                 105                 110         


Glu Asp Ala Pro Val Pro Glu Lys Thr Glu Ser Phe Thr Lys Met Leu 
        115                 120                 125             


Trp Pro Glu Gly Asn Pro Lys Phe Cys Glu Thr Ile Gln Glu Phe Ser 
    130                 135                 140                 


Glu Lys Leu Ser Lys Phe Asp Gln Met Val Arg Met Met Val Leu Glu 
145                 150                 155                 160 


Ser Leu Gly Leu Glu Lys Tyr Met Asp Glu His Met Asp Ser Thr Asn 
                165                 170                 175     


Tyr Leu Leu Arg Val Met Lys Tyr Lys Gly Pro Glu Thr Asn Glu Ser 
            180                 185                 190         


Lys Leu Gly Leu Asn Ser His Thr Asp Lys Asn Ile Val Thr Ile Leu 
        195                 200                 205             


His Gln Asn Gln Val Asn Gly Leu Glu Val Gln Thr Lys Ser Gly Asp 
    210                 215                 220                 


Trp Ile Lys Ile Gln Pro Ser Pro Asp Ser Phe Ile Val Met Ile Gly 
225                 230                 235                 240 


Asp Ser Leu Tyr Ala Trp Thr Asn Gly Arg Leu His Ser Pro Tyr His 
                245                 250                 255     


Arg Val Met Met Ser Gly Glu Lys Ala Arg Tyr Ser Phe Gly Leu Phe 
            260                 265                 270         


Ser Ile Pro Lys Ala Gly Tyr Val Ile Arg Ala Pro Ile Glu Val Val 
        275                 280                 285             


Asp Glu Gln His Pro Leu Leu Phe Lys Pro Phe Asp His Val Glu Phe 
    290                 295                 300                 


Leu Gln Phe Tyr Tyr Thr Glu Asp Gly Gln Arg Ala Gln Ser Ala Leu 
305                 310                 315                 320 


Lys Thr Tyr Cys Gly Val 
                325     


<210>  296
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  296

Met Ile Lys Gly His Ser Ser Leu Leu Ser Leu His Lys Glu His Met 
1               5                   10                  15      


Asp Cys Gln Lys Thr Pro Leu Val Phe Asp Ser Leu Ile Leu Gln His 
            20                  25                  30          


Glu Thr Asn Ile Pro Gln Gln Phe Ile Trp Pro Asp His Glu Lys Pro 
        35                  40                  45              


Asn Leu Gln Lys Ala Lys Glu Leu Val Val Pro Leu Val Asp Leu Gly 
    50                  55                  60                  


Gly Phe Leu Ser Gly Arg Pro Ser Ser Ala Lys Glu Ala Ser Val Val 
65                  70                  75                  80  


Val Gly Asp Ala Cys Lys Lys His Gly Phe Phe Leu Val Thr Asn His 
                85                  90                  95      


Gly Val Asp Ala Ser Leu Ile Ala Asp Ala His Arg Tyr Met Asp Leu 
            100                 105                 110         


Phe Phe Glu Leu Pro Leu Ser Asp Lys Gln Arg Ala Gln Arg Lys Leu 
        115                 120                 125             


Gly Glu Ser Cys Gly Tyr Ala Ser Ser Phe Thr Gly Arg Phe Ser Ser 
    130                 135                 140                 


Lys Leu Pro Trp Lys Glu Thr Leu Ser Phe Gln Phe Ser Gly Glu Lys 
145                 150                 155                 160 


Ser Ser Ala Asn Gly Val Lys Asp Tyr Phe Glu Asn Thr Leu Gly Lys 
                165                 170                 175     


Glu Phe Thr Arg Leu Gly Lys Val Tyr Gln Glu Tyr Cys Asn Ala Met 
            180                 185                 190         


Ser Arg Leu Ser Leu Gly Ile Met Glu Leu Leu Gly Met Ser Leu Gly 
        195                 200                 205             


Val His Arg Ala His Phe Lys Glu Phe Phe Glu Glu His Asp Ser Ile 
    210                 215                 220                 


Met Arg Leu Asn Tyr Tyr Pro Arg Cys Gln Lys Pro Asp Leu Thr Leu 
225                 230                 235                 240 


Gly Thr Gly Pro His Cys Asp Pro Thr Ser Leu Thr Ile Leu His Gln 
                245                 250                 255     


Asp Ser Val Gly Gly Leu Glu Val Phe Val Asp Asn Glu Trp Arg Ser 
            260                 265                 270         


Ile Ala Pro Asn Thr Asn Ala Phe Val Ile Asn Ile Gly Asp Thr Phe 
        275                 280                 285             


Met Ala Leu Ser Asn Gly Arg Tyr Lys Ser Cys Leu His Arg Ala Val 
    290                 295                 300                 


Val Asn Asn Arg Ile His Arg Lys Ser Leu Ala Phe Phe Leu Cys Pro 
305                 310                 315                 320 


Lys Lys Asp Lys Val Val Ser Pro Pro Asp Glu Leu Val Asp Glu Asn 
                325                 330                 335     


Asn Pro Arg Ile Tyr Pro Asp Phe Thr Trp Ser Thr Phe Leu Glu Phe 
            340                 345                 350         


Thr Gln Lys His Tyr Arg Ala Asp Met Asn Thr Leu Gln Ala Phe Ser 
        355                 360                 365             


Asn Trp Ile Gln Gln Arg Asn Ser 
    370                 375     


<210>  297
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  297

Met Glu Glu Ser Asp Pro Pro Phe Phe Glu Phe Tyr Lys Asn Leu Leu 
1               5                   10                  15      


Glu Lys Glu Asp Thr Ser Lys Lys Asn Val Ile Gly Val Phe Asp Asn 
            20                  25                  30          


Val Glu Glu Trp Asp Leu Pro Val Ile Asp Leu Ser Arg Leu Cys Gly 
        35                  40                  45              


Glu Gly Trp Glu Ser Ala Lys Cys Lys Lys Glu Ile Ala Glu Ala Ser 
    50                  55                  60                  


Lys Lys Trp Gly Phe Phe Gln Val Ile Asn His Gly Val Ser Asn Asp 
65                  70                  75                  80  


Ile Leu Glu Lys Met Arg Tyr Glu Gln Met Lys Val Phe Lys Asn Thr 
                85                  90                  95      


Phe His Val Lys Ala Lys Asn Lys Cys Glu Ser Asn Phe Pro Glu Gly 
            100                 105                 110         


Ser Tyr Arg Trp Gly Thr Pro Ser Ala Thr Arg Leu Arg Gln Val Ala 
        115                 120                 125             


Trp Ser Glu Ala Phe His Val Pro Leu Thr Asp Ile Ser Asn Met Gly 
    130                 135                 140                 


Gly Leu Thr Ser Leu Ser Asn Thr Met Glu Gln Phe Ala Thr Met Val 
145                 150                 155                 160 


Ser Asp Leu Ala Glu Asn Ile Ala Glu Ile Leu Ala Glu Gln Leu Gly 
                165                 170                 175     


His Lys Ser Asp Phe Phe Arg Lys Asn Cys Leu Pro Ser Thr Cys Tyr 
            180                 185                 190         


Leu Arg Met Asn Arg Tyr Pro Pro Cys Pro Ile Ser Ser Gln Val Tyr 
        195                 200                 205             


Gly Leu Met Pro His Thr Asp Ser Asp Phe Leu Thr Ile Leu Tyr Gln 
    210                 215                 220                 


Asp Gln Ile Gly Gly Leu Gln Leu Val Lys Asp Gly Lys Trp Ile Ala 
225                 230                 235                 240 


Val Lys Pro Asn Lys Asp Ala Leu Ile Ile Asn Ile Gly Asp Leu Phe 
                245                 250                 255     


Gln Ala Trp Ser Asn Asp Val Tyr Lys Ser Val Lys His Arg Val Leu 
            260                 265                 270         


Ala Asn Lys Gln Ser Gln Arg Phe Ser Thr Ala Tyr Phe Phe Cys Pro 
        275                 280                 285             


Ser Tyr Asp Thr Met Ile Gln Ser Gly Ala Glu Asn Ser Ile Tyr Lys 
    290                 295                 300                 


Arg Phe Ser Phe Arg Glu Phe Arg Gln Gln Val Gln Asp Asp Val Lys 
305                 310                 315                 320 


Arg Leu Gly Tyr Lys Ile Gly Leu Pro Arg Phe Ile Leu 
                325                 330             


<210>  298
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  298

Met Asp Pro Phe Asp Pro Pro Phe Arg Glu Thr Tyr Lys Thr Leu Phe 
1               5                   10                  15      


Asp Asn His Phe Asn Asn Glu Leu Ser Arg Lys Gly Asn Lys Ile Glu 
            20                  25                  30          


Asp Leu Gln Glu Ala Asn Glu Cys Glu Phe Glu Leu Pro Leu Val Asp 
        35                  40                  45              


Leu Ser Arg Leu Asn Gln Gly Gly Ile Glu Ser Glu Lys Cys Lys Gln 
    50                  55                  60                  


Glu Ile Ala Lys Ala Ser Gln Glu Trp Gly Phe Phe Gln Val Ile Asn 
65                  70                  75                  80  


His Gly Val Ser His Glu Val Leu Glu Asn Met Arg Ser Glu Gln Val 
                85                  90                  95      


Lys Thr Phe Lys Lys Pro Phe His Asp Lys Val Asn Gly Gln Cys Asp 
            100                 105                 110         


Gln Leu Asp Phe Leu Ala Gly Ser Tyr Arg Trp Gly Thr Pro Ser Ala 
        115                 120                 125             


Thr Cys Leu Arg Gln Leu Ala Trp Ser Glu Ala Phe His Val Pro Leu 
    130                 135                 140                 


Ser Glu Ile Ser Ala Val Asp Gly Val Thr Gly Leu Ser Thr Thr Met 
145                 150                 155                 160 


Lys Glu Tyr Thr Asn Ile Val Ser Ile Leu Ala Glu Lys Leu Ala Glu 
                165                 170                 175     


Ile Leu Ala Glu Lys Ile Gly Gln Lys Pro Lys Phe Phe Glu Glu Asn 
            180                 185                 190         


Cys Val Pro Ser Met Cys Tyr Ile Arg Met Ser Arg Tyr Pro Ser Cys 
        195                 200                 205             


Pro Ile Ser Pro His Val Phe Gly Leu Met Pro His Thr Asp Ser Asp 
    210                 215                 220                 


Phe Leu Thr Ile Leu His Gln Asp His Ile Gly Gly Leu Gln Leu Leu 
225                 230                 235                 240 


Lys Asn Gly Lys Trp Ile Ala Val Asn Pro Lys Gln Glu Thr Leu Ile 
                245                 250                 255     


Val Ile Ile Gly Asp Leu Phe Gln Ala Trp Ser Asn Gly Thr Tyr Lys 
            260                 265                 270         


Ser Val Glu His Arg Val Val Ala Asn Lys Leu Phe Glu Arg Phe Ser 
        275                 280                 285             


Thr Ala Tyr Phe Leu Cys Pro Ser Tyr Asp Thr Ile Ile Glu Ser Cys 
    290                 295                 300                 


Asp Glu Thr Pro Val Tyr Arg Arg Phe Ser Phe Lys Glu Phe Arg Gln 
305                 310                 315                 320 


Gln Val Gln Glu Asp Val Lys Asn Tyr Gly His Lys Ile Gly Leu Ser 
                325                 330                 335     


Arg Phe Leu Leu 
            340 


<210>  299
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  299

Met Pro Pro Thr Ile Leu Thr Ser Pro Met Ile Val Ser Pro Pro Lys 
1               5                   10                  15      


Glu Thr Asn Pro Phe Val Phe Asp Ala Ser Ile Leu Lys Asn Glu Thr 
            20                  25                  30          


Asn Ile Pro Ser Gln Phe Val Trp Pro Asp His Glu Lys Pro Gln Leu 
        35                  40                  45              


Glu Pro Ser Pro Pro Leu Asn Val Pro Thr Ile Asp Leu Gln Ala Phe 
    50                  55                  60                  


Phe Ser Gly Glu Pro His Ala Ile Ser Asn Ala Val Arg Leu Val Asn 
65                  70                  75                  80  


Asp Ala Cys Lys Asp His Gly Phe Phe Gln Val Ser Asn His Gly Val 
                85                  90                  95      


Asp Ser Asn Leu Ile Asp Lys Ala Ile Lys Ile Met Asp Val Phe Phe 
            100                 105                 110         


Glu Met Pro Phe Leu Glu Lys Gln Lys Ala Gln Arg Lys Cys Gly Glu 
        115                 120                 125             


Asn Tyr Gly Tyr Ala Ser Ser Phe Thr Asn Arg Phe Thr Ala Lys Leu 
    130                 135                 140                 


Pro Trp Lys Glu Thr Leu Ser Phe Arg Tyr Val Pro Asp Pro Lys Cys 
145                 150                 155                 160 


Ser Asn Ile Val Gln Asp Tyr Phe Leu Asn Val Leu Gly Glu Asp Phe 
                165                 170                 175     


Asn Glu Phe Gly Lys Val Cys Gln Glu Tyr Ser Glu Ala Met Asn Lys 
            180                 185                 190         


Leu Ser Leu Asp Ile Met Glu Leu Leu Ala Met Ser Leu Gly Ile Lys 
        195                 200                 205             


Gln Phe Phe Leu Lys Asp Phe Tyr Glu Asp Asn Asp Ser Ile Val Arg 
    210                 215                 220                 


Leu Asn Tyr Tyr Pro Thr Cys Gln Gln Pro Asp Leu Thr Leu Gly Thr 
225                 230                 235                 240 


Gly Pro His Cys Asp Pro Thr Ser Leu Thr Ile Leu His Gln Asp Asp 
                245                 250                 255     


Val Gly Gly Leu Glu Val Phe Phe Lys Glu Lys Trp His Pro Val Ala 
            260                 265                 270         


Pro Cys Pro Gly Thr Phe Val Val Asn Ile Gly Asp Thr Leu Met Ala 
        275                 280                 285             


Leu Ser Asn Gly Leu Tyr Lys Ser Cys Leu His Arg Ala Val Val Asn 
    290                 295                 300                 


Asn Glu Thr Pro Arg Lys Ser Ile Ala Tyr Phe Leu Cys Pro Arg Met 
305                 310                 315                 320 


Asp Lys Val Val Lys Pro Pro Lys Ala Leu Val Glu Asn Asn Asn Asn 
                325                 330                 335     


Gln Arg Met Tyr Pro Asp Phe Thr Trp Ser Ala Phe Leu Glu Phe Thr 
            340                 345                 350         


Gln Lys His Tyr Arg Ser Asp Met Asn Thr Ile Asp Ala Phe Ser Arg 
        355                 360                 365             


Trp Leu Gln Glu Ser Lys Glu Ile Lys Thr Thr 
    370                 375                 


<210>  300
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  300

Met Pro Pro Phe Leu Leu Thr Ser Pro Ser Val Ser Pro Thr Ile Asp 
1               5                   10                  15      


Thr Lys Ser Arg Gln Asn Pro Leu Ile Phe Asp Ala Ser Phe Leu Gln 
            20                  25                  30          


Asn Glu Thr Ser Ile Pro Gln Gln Phe Val Trp Pro Glu Asp Glu Lys 
        35                  40                  45              


Pro Tyr His Gly Pro Pro Pro Pro Gln Leu Tyr Val Pro Pro Ile Asp 
    50                  55                  60                  


Leu Lys Gly Phe Leu Ser Tyr Glu Pro Ile Ala Met Ser Asn Ala Ser 
65                  70                  75                  80  


Arg Leu Val Asp Leu Ala Cys Arg Lys His Gly Phe Phe Gln Val Ile 
                85                  90                  95      


Asn His Gly Ile Asp Ser Arg Leu Ile Asn Glu Ala His Lys Ile Met 
            100                 105                 110         


Glu Tyr Phe Phe Arg Met Pro Leu Leu Glu Lys Gln Arg Ala Gln Arg 
        115                 120                 125             


Arg Ala Gly Glu Tyr Cys Gly Tyr Ala Ser Ser Phe Thr Asn Arg Phe 
    130                 135                 140                 


Ser Ser Lys Leu Pro Trp Lys Glu Thr Leu Ser Phe Arg Tyr Ser Ala 
145                 150                 155                 160 


Asp Pro Gln Cys Leu Asn Leu Val Pro Asp Tyr Phe Leu Asn Val Met 
                165                 170                 175     


Gly Glu Asp Phe Ser His Phe Gly Arg Val Cys Gln Glu Tyr Cys Glu 
            180                 185                 190         


Ala Met Asn Lys Leu Ser Leu Val Ile Met Glu Leu Leu Gly Leu Ser 
        195                 200                 205             


Leu Gly Ile Ser Tyr Ser Cys Phe Thr Asp Phe Tyr Lys Asp Asn Asp 
    210                 215                 220                 


Ser Ile Met Arg Phe Asn Tyr Tyr Pro Pro Cys Gln Lys Pro Asp Gln 
225                 230                 235                 240 


Ala Leu Gly Thr Gly Pro His Cys Asp Pro Thr Ser Leu Thr Ile Leu 
                245                 250                 255     


His Gln Asp Asn Val Gly Gly Leu Glu Val Phe Val Glu Asp Lys Trp 
            260                 265                 270         


His Ser Val Ala Pro Cys Ser Asn Ala Phe Val Ile Asn Ile Gly Asp 
        275                 280                 285             


Thr Phe Met Ala Leu Ser Asn Gly Leu Tyr Lys Ser Cys Leu His Arg 
    290                 295                 300                 


Ala Val Val Asn Ser His Thr Pro Arg Lys Ser Leu Ala Phe Phe Leu 
305                 310                 315                 320 


Ser Pro Arg Met Asp Lys Val Ile Cys Pro Pro Lys Glu Leu Val Ala 
                325                 330                 335     


Asp Asp Asp Gln Arg Ile Tyr Pro Asp Phe Thr Trp Ser Thr Phe Leu 
            340                 345                 350         


Glu Phe Thr Gln Lys His Tyr Arg Ala Asp Met Asn Thr Leu Glu Ala 
        355                 360                 365             


Phe Ser Asn Trp Leu Arg Asn Glu Thr Lys Cys 
    370                 375                 


<210>  301
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  301

Met Asp Pro Phe Asp Pro Pro Phe Arg Glu Thr Tyr Lys Thr Leu Phe 
1               5                   10                  15      


Asp Asn His Phe Lys Asn Glu Leu Ser Thr Lys Gly Asn Lys Ile Glu 
            20                  25                  30          


Asp Leu Gln Glu Ala Asn Glu Cys Glu Phe Glu Leu Pro Leu Val Asp 
        35                  40                  45              


Leu Ser Arg Leu Ser Gln Gly Gly Ile Glu Ser Glu Lys Cys Lys Gln 
    50                  55                  60                  


Glu Ile Ala Lys Ala Ser Gln Glu Trp Gly Phe Phe Gln Val Ile Asn 
65                  70                  75                  80  


His Gly Val Ser His Glu Val Leu Glu Asn Met Arg Ser Glu Gln Val 
                85                  90                  95      


Lys Thr Phe Lys Lys Pro Phe His Asp Lys Val Asn Gly Gln Cys Asp 
            100                 105                 110         


Gln Leu Asp Phe Leu Ala Gly Ser Tyr Arg Trp Gly Thr Pro Ser Ala 
        115                 120                 125             


Thr Cys Leu Arg Gln Leu Ala Trp Ser Glu Ala Phe His Val Pro Leu 
    130                 135                 140                 


Ser Glu Ile Ser Ala Ile Asp Gly Val Thr Gly Leu Ser Thr Thr Met 
145                 150                 155                 160 


Lys Glu Tyr Thr Asn Ile Val Ser Ile Leu Ala Glu Lys Leu Ala Glu 
                165                 170                 175     


Ile Leu Ala Glu Lys Ile Gly Gln Lys Pro Lys Phe Phe Glu Glu Asn 
            180                 185                 190         


Cys Val Pro Ser Met Cys Tyr Ile Arg Met Ser Arg Tyr Pro Ser Cys 
        195                 200                 205             


Pro Val Ser Pro His Val Phe Gly Leu Met Pro His Thr Asp Ser Asp 
    210                 215                 220                 


Phe Leu Thr Ile Leu His Gln Asp His Ile Gly Gly Leu Gln Leu Leu 
225                 230                 235                 240 


Lys Asn Gly Lys Trp Ile Ala Val Asn Pro Lys Gln Glu Thr Leu Ile 
                245                 250                 255     


Val Ile Ile Gly Asp Leu Phe Gln Ala Trp Ser Asn Gly Thr Tyr Lys 
            260                 265                 270         


Ser Val Glu His Arg Val Val Ala Asn Lys Leu Phe Glu Arg Phe Ser 
        275                 280                 285             


Thr Ala Tyr Phe Leu Cys Pro Ser Tyr Asp Thr Ile Ile Glu Ser Cys 
    290                 295                 300                 


Asp Glu Thr Pro Val Tyr Arg Arg Phe Ser Phe Lys Glu Phe Arg Gln 
305                 310                 315                 320 


Gln Val Gln Glu Asp Val Lys Asn Tyr Gly His Lys Ile Gly Leu Ser 
                325                 330                 335     


Arg Phe Leu Leu 
            340 


<210>  302
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  302

Met Pro Pro Thr Ile Leu Thr Ser Pro Met Ile Val Ser Pro Pro Lys 
1               5                   10                  15      


Glu Thr Asn Pro Phe Val Phe Asp Ala Ser Ile Leu Lys Asn Glu Thr 
            20                  25                  30          


Asn Ile Pro Ser Gln Phe Val Trp Pro Asp His Glu Lys Pro Gln Leu 
        35                  40                  45              


Glu Pro Ser Pro Pro Leu Asn Val Pro Thr Ile Asp Leu Gln Ala Phe 
    50                  55                  60                  


Phe Ser Gly Glu Pro His Ala Ile Ser Asn Ala Val Arg Leu Val Asn 
65                  70                  75                  80  


Asp Ala Cys Lys Asp His Gly Phe Phe Gln Val Ser Asn His Gly Val 
                85                  90                  95      


Asp Ser Asn Leu Ile Asp Lys Ala Ile Lys Ile Met Asp Val Phe Phe 
            100                 105                 110         


Glu Met Pro Phe Leu Glu Lys Gln Lys Ala Gln Arg Lys Cys Gly Glu 
        115                 120                 125             


Asn Tyr Gly Tyr Ala Ser Ser Phe Thr Asn Arg Phe Thr Ala Lys Leu 
    130                 135                 140                 


Pro Trp Lys Glu Thr Leu Ser Phe Arg Tyr Val Pro Asp Pro Lys Cys 
145                 150                 155                 160 


Ser Asn Ile Val Gln Asp Tyr Phe Leu Asn Val Leu Gly Glu Asp Phe 
                165                 170                 175     


Asn Glu Phe Gly Lys Val Cys Gln Glu Tyr Ser Glu Ala Met Asn Lys 
            180                 185                 190         


Leu Ser Leu Asp Ile Met Glu Leu Leu Ala Met Ser Leu Gly Ile Lys 
        195                 200                 205             


Gln Phe Phe Leu Lys Asp Phe Tyr Glu Asp Asn Asp Ser Ile Val Arg 
    210                 215                 220                 


Leu Asn Tyr Tyr Pro Thr Cys Gln Gln Pro Asp Leu Thr Leu Gly Thr 
225                 230                 235                 240 


Gly Pro His Cys Asp Pro Thr Ser Leu Thr Ile Leu His Gln Asp Asp 
                245                 250                 255     


Val Gly Gly Leu Glu Val Phe Phe Asn Glu Lys Trp His Pro Val Ala 
            260                 265                 270         


Pro Cys Pro Gly Thr Phe Val Val Asn Ile Gly Asp Thr Leu Met Ala 
        275                 280                 285             


Leu Ser Asn Gly Leu Tyr Lys Ser Cys Leu His Arg Ala Val Val Asn 
    290                 295                 300                 


Asn Glu Thr Pro Arg Lys Ser Ile Ala Tyr Phe Leu Cys Pro Arg Met 
305                 310                 315                 320 


Asp Lys Val Val Lys Pro Pro Lys Ala Leu Val Glu Asn Asn Asn Asn 
                325                 330                 335     


Gln Arg Met Tyr Pro Asp Phe Thr Trp Ser Ala Phe Leu Glu Phe Thr 
            340                 345                 350         


Gln Lys His Tyr Arg Ser Asp Met Asn Thr Ile Asp Ala Phe Ser Arg 
        355                 360                 365             


Trp Leu Gln Glu Ser Lys Glu Ile Lys Thr Thr 
    370                 375                 


<210>  303
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  303

Met Lys Glu Leu Pro Asp Ser Tyr Thr Trp Ala Ser Val Asp Asp Gly 
1               5                   10                  15      


Pro Leu Leu Ser Cys Ser Ser Glu Pro Val Pro Val Ile Asn Leu Glu 
            20                  25                  30          


Asp Pro Asn Val Met Gln His Val Gly His Ala Cys Lys Thr Trp Gly 
        35                  40                  45              


Val Phe His Val Thr Asn His Gly Ile Pro Thr Ala Val Leu Asp Asp 
    50                  55                  60                  


Met Glu Ala Ser Val Arg Lys Leu Phe Tyr Leu Pro Ile Gln Gln Lys 
65                  70                  75                  80  


Leu Lys Ala Ala Arg Ala Pro Asp Gly Val Ser Gly Tyr Gly Ala Val 
                85                  90                  95      


Arg Ile Ser Ser Phe Phe His Lys His Met Trp Ser Glu Gly Phe Thr 
            100                 105                 110         


Ile Ile Gly Ser Pro Tyr Glu His Ala Lys Lys Leu Trp Pro Gln Asp 
        115                 120                 125             


Tyr Lys Asn Phe Cys Glu Val Val Asp Glu Tyr Asn Lys Glu Met Lys 
    130                 135                 140                 


Lys Leu Thr Asn Arg Leu Met Trp Leu Val Leu Gly Ser Leu Gly Ile 
145                 150                 155                 160 


Thr Glu Gly Asp Val Lys Trp Ala Arg Gln Lys Gln Asp Ile Lys Glu 
                165                 170                 175     


Ala Cys Pro Ala Leu Gln Leu Asn Ser Tyr Pro Ala Cys Pro Asp Pro 
            180                 185                 190         


Asp Arg Ala Met Gly Leu Ala Ala His Thr Asp Ser Ser Leu Leu Thr 
        195                 200                 205             


Ile Leu His Gln Asn Asn Thr Ser Gly Leu Gln Val Gln Arg Glu Arg 
    210                 215                 220                 


Met Gly Trp Val Thr Val Pro Pro Ile Lys Gly Ala Leu Val Val His 
225                 230                 235                 240 


Val Gly Asp Leu Leu His Ile Leu Ser Asn Gly Leu Tyr Ser Ser Val 
                245                 250                 255     


Leu His Arg Ala Ile Val Asn Arg Thr Gln His Arg Leu Ser Ile Ala 
            260                 265                 270         


Tyr Leu Tyr Gly Pro Pro Ser Asn Val Arg Ile Ser Pro Leu Ser Lys 
        275                 280                 285             


Leu Thr Ser Ile Val Arg Pro Pro Leu Tyr Gln Pro Val Thr Trp Ser 
    290                 295                 300                 


Glu Tyr Leu Ala Met Lys Ala Lys Tyr Phe Asn Lys Thr Leu Ser Val 
305                 310                 315                 320 


Leu Arg Leu Ser Ala Pro Val Asn Gly Phe Val Asp Leu Lys Asp His 
                325                 330                 335     


Lys Ser Val Ile Val Gly 
            340         


<210>  304
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  304

Met Ser Leu Lys Ile Gln Lys Ala Glu Lys His Met Asp Leu Ser Ser 
1               5                   10                  15      


Met Lys Gln Leu Pro Asp Ser Tyr Thr Trp Ala Ser Val Asp Asp Gly 
            20                  25                  30          


Tyr Leu Leu Ser Cys Ser Ser Glu Pro Val Pro Val Ile Asn Leu Glu 
        35                  40                  45              


Asp Pro Asn Val Met Lys His Val Gly His Ala Cys Lys Thr Trp Gly 
    50                  55                  60                  


Val Phe His Val Thr Asn His Gly Ile Pro Lys Ala Val Leu Asp Asp 
65                  70                  75                  80  


Met Glu Ala Ser Val Arg Lys Leu Phe Tyr Leu Pro Ile Gln Gln Lys 
                85                  90                  95      


Leu Lys Ala Ala Arg Ala Pro Asp Gly Val Ser Gly Tyr Gly Ala Val 
            100                 105                 110         


Arg Ile Ser Ser Phe Phe His Lys His Met Trp Ser Glu Gly Phe Thr 
        115                 120                 125             


Ile Ile Gly Ser Pro Tyr Glu His Ala Lys Lys Leu Trp Pro Gln Asp 
    130                 135                 140                 


Tyr Lys Asn Phe Cys Glu Val Val Asp Lys Tyr Asn Lys Glu Met Lys 
145                 150                 155                 160 


Lys Leu Thr Asn Arg Leu Met Trp Leu Val Leu Gly Ser Leu Gly Ile 
                165                 170                 175     


Thr Glu Gly Asp Val Lys Trp Ala Arg Gln Thr Gln Asp Ile Lys Glu 
            180                 185                 190         


Ala Cys Pro Ala Leu Gln Leu Asn Ser Tyr Pro Ala Cys Pro Asp Pro 
        195                 200                 205             


Asp Arg Ala Met Gly Leu Ala Ala His Thr Asp Ser Ser Ile Leu Thr 
    210                 215                 220                 


Ile Leu His Gln Asn Asn Thr Ser Gly Leu Gln Val Gln Arg Glu Gly 
225                 230                 235                 240 


Met Gly Trp Val Thr Val Pro Pro Ile Lys Gly Ala Leu Val Val His 
                245                 250                 255     


Val Gly Asp Leu Leu His Ile Leu Ser Asn Gly Leu Tyr Ser Ser Val 
            260                 265                 270         


Leu His Arg Ala Ile Val Asn Arg Thr Gln His Arg Leu Ser Ile Ala 
        275                 280                 285             


Tyr Leu Tyr Gly Pro Pro Ser Asn Val Arg Ile Ser Pro Leu Ser Lys 
    290                 295                 300                 


Leu Thr Ser Ile Val His Pro Pro Leu Tyr Gln Pro Val Thr Trp Ser 
305                 310                 315                 320 


Glu Tyr Leu Ala Met Lys Ala Lys Tyr Phe Asn Lys Thr Leu Ser Val 
                325                 330                 335     


Leu Arg Leu Ser Ala Pro Val Asn Gly Phe Ile Asp Leu Lys Asp His 
            340                 345                 350         


Lys Ser Val Ile Val Gly 
        355             


<210>  305
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  305

Met Gly Glu Leu Asp Pro Asn Phe Ile Gln Glu Pro Asp His Arg Pro 
1               5                   10                  15      


Lys Leu Ala Ile Ile Glu Ala Glu Gly Ile Pro Gln Ile Asp Leu Ser 
            20                  25                  30          


Pro Leu Ile Asn Ser Ser Pro Ala Asp Tyr Asn Ala Ala Ala Val Gln 
        35                  40                  45              


Asp Leu Ile Gly Glu Val Arg Asp Ala Cys Lys Asn Trp Gly Phe Phe 
    50                  55                  60                  


Gln Val Phe Asn His Gly Val Pro Phe Glu Ser Arg Glu Asn Leu Phe 
65                  70                  75                  80  


Ser Ala Ser Lys Arg Phe Tyr Asp Gln Pro Val Glu Glu Lys Arg Lys 
                85                  90                  95      


Val Arg Arg Asp Glu Ala Asn Pro Gln Gly Tyr Tyr Asp Thr Glu His 
            100                 105                 110         


Thr Lys Asn Val Arg Asp Trp Lys Glu Val Phe Asp Ile Thr Val Glu 
        115                 120                 125             


Asn Pro Thr Lys Met Phe Ala Ser His Glu Ala Asp Asp Glu Arg Ile 
    130                 135                 140                 


Thr Gln Tyr Ile Asn Arg Trp Pro Glu His Pro Pro Glu Leu Arg Glu 
145                 150                 155                 160 


Ala Cys Glu Ala Tyr Val Lys Asp Val Gln Gln Leu Ser Tyr Lys Leu 
                165                 170                 175     


Leu Glu Leu Ile Ser Leu Ser Leu Gly Leu Pro Ala Asn Gln Phe Glu 
            180                 185                 190         


Pro Phe Phe Ser Lys Asp Gln Thr Ser Tyr Ile Arg Leu Asn His Tyr 
        195                 200                 205             


Pro Pro Cys Pro Val Pro Asp Leu Ala Leu Gly Val Gly Arg His Lys 
    210                 215                 220                 


Asp Ala Phe Ala Leu Thr Ile Leu Ala Gln Asp Asp Val Gly Gly Leu 
225                 230                 235                 240 


Glu Val Lys Arg Lys Thr Asp Gly Glu Trp Ile Phe Val Lys Pro Thr 
                245                 250                 255     


Pro Asn Thr Phe Ile Ile Asn Val Gly Asp Met Ile Gln Val Trp Ser 
            260                 265                 270         


Asn Asp Arg Tyr Glu Ser Val Glu His Arg Val Met Val Asn Ser Thr 
        275                 280                 285             


Lys Glu Arg Phe Ser Ile Pro Phe Phe Leu Ser Pro Ser Tyr Tyr Thr 
    290                 295                 300                 


Val Val Glu Pro Leu Ala Glu Leu Ile Asp Glu Gln Asn Pro Pro Lys 
305                 310                 315                 320 


Tyr Lys Gly Tyr Ser Trp Gly Lys Phe Phe Ala Thr Arg Lys Arg Ser 
                325                 330                 335     


Asn Phe Gln Lys Leu Lys Val Glu Asn Ile Gln Ile Tyr His Phe Lys 
            340                 345                 350         


Ile Pro Asn Glu Gln Lys Ser Asp Asp Val Val Ser Cys Val Glu Asn 
        355                 360                 365             


Leu Ala Ile 
    370     


<210>  306
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  306

Met Glu Asp Asn Thr Asn Glu Ile Ile Asn Arg Ser Glu Tyr Gly Gly 
1               5                   10                  15      


Ser Ile Pro Val Asp Asn Val Gln Ala Leu Ala Ser Ser Lys Asp Leu 
            20                  25                  30          


Lys Asp Ile Pro Ser Arg Tyr Ile Arg Pro Glu Ile Glu Leu Asp Val 
        35                  40                  45              


Val Leu Thr Asp Glu Ser Leu Gln Ile Pro Val Ile Asp Ile Ser Lys 
    50                  55                  60                  


Leu Ala Val Ala Glu Gln Pro Gly Tyr Asp Asp Glu Leu Glu Asn Leu 
65                  70                  75                  80  


His Val Ala Cys Arg Asp Trp Gly Phe Phe Gln Leu Ile Asn His Gly 
                85                  90                  95      


Ile Ser Glu Ser Ile Asp Ala Met Lys Lys Val Thr His Glu Phe Phe 
            100                 105                 110         


Asn Leu Pro Leu Glu Glu Lys Met Lys Cys Ala Gln Met Pro Asn Asn 
        115                 120                 125             


Ile Glu Gly Tyr Gly Gln Ala Phe Val Val Ser Gln Glu Gln Lys Leu 
    130                 135                 140                 


Asp Trp Gly Asp Met Leu Phe Ile Leu Pro Leu Pro Ile Pro Gln Arg 
145                 150                 155                 160 


Asn Met Met Phe Trp Pro Gln Asn Pro Asp Ser Phe Lys Thr Thr Leu 
                165                 170                 175     


Asp Lys Tyr Ser Asp Thr Leu Tyr Gly Val Ser Met Lys Leu Leu Lys 
            180                 185                 190         


Leu Ile Ser Ile Asn Leu Gly Ile Lys Pro Glu Ala Ile Thr Lys Met 
        195                 200                 205             


Phe Glu Asn Cys Asn Gln Gly Ile Arg Met Asn His Tyr Pro Pro Cys 
    210                 215                 220                 


Pro Glu Ala Asn Lys Val Leu Gly Leu Thr Pro His Ser Asp Ala Thr 
225                 230                 235                 240 


Gly Leu Thr Leu Leu Val Gln Val Asn Asp Val Gln Gly Leu Gln Ile 
                245                 250                 255     


Lys Lys Asn Phe Lys Trp Val Pro Ile Lys Pro Leu Pro Gly Ser Ile 
            260                 265                 270         


Ile Val Asn Ile Gly Asp Val Met Glu Ile Met Ser Asn Gly Glu Tyr 
        275                 280                 285             


Lys Ser Ile Glu His Arg Ala Val Val Asn Phe Glu Asp Glu Arg Leu 
    290                 295                 300                 


Ser Ile Ala Ala Phe His Ser Pro Asp Ile Glu Ala Met Ile Gly Pro 
305                 310                 315                 320 


Leu Thr Glu Leu Val Lys Asp Asn Thr Pro Lys Tyr Lys Thr Ile Gly 
                325                 330                 335     


Ser Glu Asp Tyr Leu Lys Leu Ile Ile Asn Ser Lys Leu Asp Gly Lys 
            340                 345                 350         


Ser Leu Ile Asp Gln Met Lys Ile 
        355                 360 


<210>  307
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  307

Met Ile Glu Ser Asn Gln Asn Pro Pro Leu Leu Arg Asp Tyr Thr Gln 
1               5                   10                  15      


Leu Leu His Glu Ser Arg Asp Lys Val Asp Val Lys Arg Leu Val Asn 
            20                  25                  30          


His Glu Pro Gly Met Glu Glu Cys Glu Leu Pro Leu Val Asp Leu Ser 
        35                  40                  45              


Gly Leu Trp Gly Glu Asn Glu Glu Asp Arg Val Ser Cys Ala Ser Glu 
    50                  55                  60                  


Ile Cys Lys Ala Ser Ser Glu Trp Gly Phe Phe Gln Ile Val Asn His 
65                  70                  75                  80  


Gly Ile Asn Leu Glu Leu Leu Arg Lys Met Arg Lys Glu Gln Val Glu 
                85                  90                  95      


Leu Phe Lys Ala Ser Phe Glu Arg Lys Thr Ala Asp Gly Leu Leu Asp 
            100                 105                 110         


Asn Ser Tyr Arg Trp Gly Asn Arg Thr Ala Thr Cys Pro Lys Gln Leu 
        115                 120                 125             


Ser Trp Cys Glu Ala Phe His Val Pro Leu Thr Lys Ile Ser Asp Asp 
    130                 135                 140                 


Thr Cys Tyr Gly Glu Phe Asp Ser Leu Arg Glu Val Met Gln Glu Tyr 
145                 150                 155                 160 


Ala Ser Ala Met Gln Glu Leu Ala Lys Ser Ile Ser Lys Val Leu Val 
                165                 170                 175     


Thr Asn Met Gly Val Gln Gln Gly Val Trp Glu Asp Asn Cys Asp Ala 
            180                 185                 190         


Ser Thr Cys Phe Ile Arg Leu Asn Arg Tyr Pro Pro Cys Pro Ile Ser 
        195                 200                 205             


Pro Glu Val Phe Gly Leu Val Pro His Thr Asp Ser Asp Phe Leu Thr 
    210                 215                 220                 


Ile Leu His Gln Asp Glu His Val Gly Gly Leu Gln Leu Met Lys Asp 
225                 230                 235                 240 


Ser Lys Trp Val Ala Val Lys Pro Asn Thr Asn Ala Leu Val Val Asn 
                245                 250                 255     


Ile Gly Asp Leu Phe Gln Ala Trp Ser Asn Asp Val Tyr Lys Ser Val 
            260                 265                 270         


Glu His Lys Val Ile Val Asn Gln Glu Ala Glu Arg His Ser Ile Ala 
        275                 280                 285             


Tyr Phe Leu Cys Pro Ser Tyr Glu Ser Phe Ile Gly Cys Cys Glu Glu 
    290                 295                 300                 


Glu Arg Ser Ile Tyr Arg Arg Phe Thr Phe Gly Glu Tyr Arg Ser Gln 
305                 310                 315                 320 


Ile Gln Gln Asp Val Lys Thr Phe Gly His Lys Val Gly Leu Pro Arg 
                325                 330                 335     


Phe Leu Ala Ser Thr 
            340     


<210>  308
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  308

Met Ala Ile Asp Cys Met Ile Lys Thr Thr Ser Asn Met Pro Ser Leu 
1               5                   10                  15      


Lys Glu Asp Gln Arg Lys Ser Phe Val Phe Asp Ala Ser Val Leu Lys 
            20                  25                  30          


His Glu Ser Asn Ile Pro Gln Gln Phe Ile Trp Pro Asp His Glu Lys 
        35                  40                  45              


Pro Asn Ser Gln Lys Ser Lys Glu Leu Glu Val Pro Leu Val Asp Leu 
    50                  55                  60                  


Gly Gly Phe Leu Ser Gly Arg Ser Ser Ser Ala Lys Glu Ala Ser Ser 
65                  70                  75                  80  


Leu Val Gly Glu Ala Cys Gln Lys His Gly Phe Phe Leu Val Val Asn 
                85                  90                  95      


His Gly Val Asp Glu Asn Leu Ile Ser Asp Ala Gln Arg Tyr Met Asp 
            100                 105                 110         


Leu Phe Phe Glu Leu Pro Leu Ser Val Lys Gln Arg Ala Gln Arg Lys 
        115                 120                 125             


Val Gly Glu Ser Cys Gly Tyr Ala Ser Ser Phe Thr Gly Arg Phe Ser 
    130                 135                 140                 


Ser Lys Leu Pro Trp Lys Glu Thr Leu Ser Phe Arg Phe Ser Ala Glu 
145                 150                 155                 160 


Glu Asn Ala Ser Asn Ile Val Lys Asp Tyr Phe Glu Asn Thr Met Gly 
                165                 170                 175     


Glu Glu Phe Ile Arg Leu Gly Lys Val Tyr Gln Glu Tyr Cys Asn Ala 
            180                 185                 190         


Met Ser Arg Leu Ser Leu Gly Ile Met Glu Leu Leu Gly Met Ser Leu 
        195                 200                 205             


Gly Val Ser Arg Ala Tyr Tyr Lys Glu Phe Phe Glu Glu His Asn Ser 
    210                 215                 220                 


Ile Met Arg Leu Asn Tyr Tyr Pro Pro Cys Gln Lys Pro Asp Leu Thr 
225                 230                 235                 240 


Leu Gly Thr Gly Pro His Cys Asp Pro Thr Ser Leu Thr Ile Leu His 
                245                 250                 255     


Gln Asp Asn Val Gly Gly Leu Glu Val Phe Val Asp Asn Glu Trp Arg 
            260                 265                 270         


Leu Ile Ala Pro Ser Ser Asn Ala Phe Val Val Asn Ile Gly Asp Thr 
        275                 280                 285             


Phe Met Ala Leu Ser Asn Gly Arg Tyr Lys Ser Cys Leu His Arg Ala 
    290                 295                 300                 


Val Val Asn Ser Lys Thr Thr Arg Lys Ser Leu Ala Phe Phe Leu Cys 
305                 310                 315                 320 


Pro Lys Lys Asp Lys Val Val Ile Pro Pro Lys Glu Leu Val Asp Glu 
                325                 330                 335     


Asn Asn Pro Arg Ile Tyr Pro Asp Phe Thr Trp Ser Thr Phe Leu Glu 
            340                 345                 350         


Phe Thr Gln Lys His Tyr Arg Ala Asp Lys Asn Thr Leu Gln Ala Phe 
        355                 360                 365             


Ser Thr Trp Gly Val Asn Asn Ala Gln Pro Glu Leu Gln Ala Ser Ser 
    370                 375                 380                 


Ser Lys Asn Ala Ser Glu Gly Lys Asp Val Ile Thr Thr Ser Gly Glu 
385                 390                 395                 400 


Thr Gln Ile Lys Pro Ser Val Pro Thr Lys Val Asn Glu Ser Glu His 
                405                 410                 415     


Glu Asp Lys Phe Leu Asp Leu Leu Gln Ile Met Leu Val Leu Asp Lys 
            420                 425                 430         


Arg Thr Leu Leu Asp Gln Leu Asn Ala Phe Glu Thr Glu Glu Gln Ile 
        435                 440                 445             


Val Gln Thr Glu Gln Ala Ile Val Pro Val Asn Lys Ala Ser Gly Gly 
    450                 455                 460                 


Asn Asn Gln Asn Gly Phe Lys Ser Arg Asn Lys Ile Phe Asn Asp Ala 
465                 470                 475                 480 


Leu Lys Phe Leu Gln His Asp Asp Gly Lys Thr Gln Val Ile Ala Leu 
                485                 490                 495     


Cys Gly Met Gly Gly Val Gly Lys Thr Thr Leu Met Asn Gln Leu Lys 
            500                 505                 510         


Glu Ala Ala Lys Asn Glu Lys Met Phe Gln Trp Ile Met Val Leu Ile 
        515                 520                 525             


Ile Gly Lys Ser Ser Asn Leu Phe Ala His Gln Asn Ala Ile Ala Val 
    530                 535                 540                 


His Thr Gly Glu Pro Leu Thr Lys Thr Asp Glu Lys Leu Arg Ala Thr 
545                 550                 555                 560 


Tyr Phe Ser Lys Arg Phe Arg Glu Phe Ser Glu His Lys Glu Lys Ser 
                565                 570                 575     


Leu Val Ile Leu Asp Asp Val Trp Glu Lys Ile Lys Leu Lys Asp Ile 
            580                 585                 590         


Gly Leu Ala Gly Ala Leu Pro Asn Gly Glu Ile Ser Asn Lys Leu Ile 
        595                 600                 605             


Asp Ile Glu Leu Lys Met Asp Ser Thr Leu Ala Thr Glu Asp Glu Arg 
    610                 615                 620                 


Val Glu Arg Ile Gln Leu Leu Arg Asp Leu Asn Asp Ile Asp Arg Leu 
625                 630                 635                 640 


Glu Ser Leu Asp Leu Leu Gln Lys Ser Arg Leu Lys Trp Ala Ala Glu 
                645                 650                 655     


Gly Asp Glu Asn Ser Lys Phe Phe His Gly Leu Leu Lys Gln Lys Arg 
            660                 665                 670         


Ser Arg Gln Ser Ile Gln Gly Ile Met Leu Asp Gly Glu Trp Ile Ser 
        675                 680                 685             


Asn Pro Ile Ser His Arg Arg Glu Tyr 
    690                 695         


<210>  309
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  309

Met Ser Leu His Val Gln Pro Ala Asp His Leu Gln Gln Gln Asn Asn 
1               5                   10                  15      


Met Tyr Gln Lys Gly Val Lys His Leu Cys Asp Asn Gly Leu Thr Gln 
            20                  25                  30          


Val Pro Asn Lys Tyr Ile Leu Pro Glu Pro Glu Arg Pro Gln Ser Leu 
        35                  40                  45              


Val Val Glu Gly Cys Ile Asp Leu Pro Val Ile Asp Phe Ala Gln Leu 
    50                  55                  60                  


Gln Gly Ala Asp Lys Pro Gln Val Leu Ala Ser Leu Ser Lys Ala Cys 
65                  70                  75                  80  


Gln Glu Phe Gly Phe Phe Gln Leu Val Asn His Gly Ile Gly Asn Glu 
                85                  90                  95      


Ala Ile Gly Lys Met Ile Asp Val Ser Lys Arg Phe Phe Glu Leu Pro 
            100                 105                 110         


Phe Glu Glu Arg Gln Arg Tyr Met Ser Ser Asp Leu Tyr Ala Pro Val 
        115                 120                 125             


Arg Tyr Gly Thr Ser Phe Asn Gln Asn Asn Asp Gly Ile Phe Cys Trp 
    130                 135                 140                 


Arg Asp Phe Leu Lys Leu Ser Cys His Pro Met Gln Asp Phe Ala Ser 
145                 150                 155                 160 


Leu Trp Pro Ser Ser Pro Val Asp Leu Arg Glu Thr Leu Gly Glu Tyr 
                165                 170                 175     


Ser Thr Lys Thr Gln His Leu Tyr Lys Met Val Met Glu Ala Ile Leu 
            180                 185                 190         


Glu Ser Ile Gly Val Thr Asn Glu Lys Ala Ile Ser Glu Glu Gly Asn 
        195                 200                 205             


Gln Leu Met Met Val Asn Trp Tyr Pro Ala Cys Pro Gln Pro Gln Leu 
    210                 215                 220                 


Thr Leu Gly Leu Pro Pro His Ser Asp Tyr Gly Leu Leu Thr Leu Leu 
225                 230                 235                 240 


Leu Gln Asp Gln Val Glu Gly Leu Gln Ile Gln His Asn Gly Lys Trp 
                245                 250                 255     


Val Thr Val Lys Pro Ile Pro Asn Ser Phe Val Val Asn Ile Gly Asp 
            260                 265                 270         


Gln Phe Glu Ile Phe Ser Asn Gly Arg Phe Lys Ser Val Val His Arg 
        275                 280                 285             


Val Ala Val Asn Ser Thr Arg Ser Arg Leu Ser Val Ala Ser Leu His 
    290                 295                 300                 


Ser Leu Gln Ala Asn Arg Asn Val Thr Pro Ser Pro Lys Leu Ile Asp 
305                 310                 315                 320 


Glu Ser Asn Pro Arg Arg Tyr Arg Asp Thr Ser Tyr Ala Asp Phe Leu 
                325                 330                 335     


Asp Tyr Leu Ser Ser Ser Asp Phe Lys Cys Lys Arg Phe Leu Glu Ser 
            340                 345                 350         


Arg Glu Leu His 
        355     


<210>  310
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  310

Met Ala Ala Val Ser Lys Arg Leu Leu Val Ser Asp Leu Val Thr Val 
1               5                   10                  15      


Asp Lys Ile Asn Gln Val Pro Ser Asn Tyr Ile Arg Pro Leu Ser Glu 
            20                  25                  30          


Arg Pro Asn Leu Arg His Val Ser Ser His Glu Thr Ile Pro Ile Ile 
        35                  40                  45              


Asp Leu His Asp Leu Asn Ser Pro Lys Arg Cys His Val Ile Asn Gln 
    50                  55                  60                  


Ile Arg Asp Ala Cys Arg Glu Tyr Gly Phe Phe Gln Val Lys Asn His 
65                  70                  75                  80  


Ser Val Pro Glu Ser Thr Ile Thr Asn Met Met Gln Ile Ala Lys Asp 
                85                  90                  95      


Phe Phe Asn Leu Pro Glu Glu Glu Arg Leu Lys Ser Tyr Ser Asp Asp 
            100                 105                 110         


Pro Asn Lys Thr Thr Arg Leu Ser Thr Ser Phe Asn Ile Arg Thr Glu 
        115                 120                 125             


Lys Val Ala Asn Trp Arg Asp Phe Leu Arg Leu His Cys Tyr Pro Leu 
    130                 135                 140                 


Glu Asp Tyr Val His Glu Trp Pro Thr Asn Pro Ser Ser Phe Arg Ala 
145                 150                 155                 160 


His Val Lys Glu Tyr Cys Thr Ser Val Arg Gly Leu Ala Leu Glu Leu 
                165                 170                 175     


Val Glu Ala Ile Ser Glu Ser Leu Gly Leu Glu Arg Asp Tyr Ile Gly 
            180                 185                 190         


Lys Gln Leu Gly Lys His Gly Gln His Met Ala Leu Asn Tyr Tyr Pro 
        195                 200                 205             


Pro Cys Pro Gln Pro Asp Leu Thr Tyr Gly Leu Pro Gly His Thr Asp 
    210                 215                 220                 


Leu Asn Leu Ile Thr Ile Leu Leu Gln Asp Asp Val Pro Gly Leu Gln 
225                 230                 235                 240 


Val Leu Lys Asp Gly Lys Trp Val Ala Val Asp Pro Val Pro Asn Thr 
                245                 250                 255     


Phe Ile Ile Asn Ile Gly Asp Gln Ile Gln Val Leu Ser Asn Asp Lys 
            260                 265                 270         


Tyr Lys Ser Ile Leu His Arg Ala Val Val Asn Cys Asp Lys Glu Arg 
        275                 280                 285             


Ile Ser Ile Pro Thr Phe Tyr Cys Pro Ser Arg Asp Ala Val Ile Ser 
    290                 295                 300                 


Pro Ala Pro Glu Phe Val Thr Glu Asp Gln Pro Ala Val Tyr Arg Pro 
305                 310                 315                 320 


Phe Thr Tyr Gly Glu Tyr Tyr Asp Lys Phe Trp Asn Arg Gly Leu Ala 
                325                 330                 335     


Thr Glu Asn Cys Leu Asp Met Phe Met Ala Thr Lys Ser Thr 
            340                 345                 350 


<210>  311
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  311

Met Glu Asp Asn Thr Asn Glu Ile Ile Asn Arg Ser Glu Tyr Gly Gly 
1               5                   10                  15      


Ser Ile Pro Val Asp Asn Val Gln Ala Leu Ala Ser Ser Lys Asp Leu 
            20                  25                  30          


Lys Asp Ile Pro Ser Arg Tyr Ile Arg Pro Glu Ile Glu Leu Asp Val 
        35                  40                  45              


Val Leu Thr Asp Glu Ser Leu Gln Ile Pro Val Ile Asp Ile Ser Lys 
    50                  55                  60                  


Leu Ala Val Ala Gly Gln Pro Gly Tyr Asp Asp Glu Leu Glu Asn Leu 
65                  70                  75                  80  


His Val Ala Cys Arg Asp Trp Gly Phe Phe Gln Leu Ile Asn His Gly 
                85                  90                  95      


Ile Ser Glu Ser Ile Asp Ala Met Lys Lys Val Thr His Glu Phe Phe 
            100                 105                 110         


Asn Leu Pro Leu Glu Glu Lys Met Lys Cys Ala Gln Met Pro Asn Asn 
        115                 120                 125             


Ile Glu Gly Tyr Gly Gln Ala Phe Val Val Ser Gln Glu Gln Lys Leu 
    130                 135                 140                 


Asp Trp Gly Asp Met Leu Phe Ile Leu Pro Leu Pro Ile Pro Gln Arg 
145                 150                 155                 160 


Asn Met Met Phe Trp Pro Glu Asn Pro Asp Ser Phe Lys Thr Thr Leu 
                165                 170                 175     


Asp Lys Tyr Ser Asp Thr Leu Tyr Gly Val Ser Met Lys Leu Leu Lys 
            180                 185                 190         


Leu Ile Ser Ile Asn Leu Gly Ile Lys Pro Glu Ala Ile Thr Lys Met 
        195                 200                 205             


Phe Glu Asn Cys Asn Gln Gly Ile Arg Met Asn Tyr Tyr Pro Pro Cys 
    210                 215                 220                 


Pro Glu Ala Asn Lys Val Leu Gly Leu Thr Pro His Ser Asp Ala Thr 
225                 230                 235                 240 


Gly Leu Thr Leu Leu Val Gln Val Asn Asp Val Gln Gly Leu Gln Ile 
                245                 250                 255     


Lys Lys Asn Ser Lys Trp Val Pro Ile Lys Pro Leu Pro Gly Ser Val 
            260                 265                 270         


Ile Val Asn Ile Gly Asp Val Met Glu Ile Met Ser Asn Gly Glu Tyr 
        275                 280                 285             


Lys Ser Ile Glu His Arg Ala Val Val Asn Phe Glu Asp Glu Arg Leu 
    290                 295                 300                 


Ser Ile Ala Ala Phe His Ser Pro Gly Ile Glu Ala Met Ile Gly Pro 
305                 310                 315                 320 


Leu Thr Glu Leu Ile Lys Asp Asn Thr Pro Lys Tyr Lys Thr Ile Gly 
                325                 330                 335     


Ser Glu Asp Tyr Leu Lys Leu Ile Ile Asn Ser Lys Leu Asp Gly Lys 
            340                 345                 350         


Ser Leu Ile Asp Gln Met Arg Ile Glu 
        355                 360     


<210>  312
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  312

Met Gly Ser Gln Ala Leu Ser Arg Leu Pro Thr Ile Asp Phe Ser Asn 
1               5                   10                  15      


Val Asn Lys Gln Asn Arg Asp Ser Val Trp Asp Ser Thr Lys Thr Gln 
            20                  25                  30          


Val Phe Glu Ala Leu Gln Glu Phe Gly Cys Phe Glu Ala Ser Phe Asn 
        35                  40                  45              


Gly Ile Ser His Asp Leu Arg Asn Ser Val Phe Ser Ser Leu Lys Glu 
    50                  55                  60                  


Leu Phe Asp Leu Pro Leu Glu Thr Lys Val Arg Asn Phe Thr Glu Lys 
65                  70                  75                  80  


Leu Tyr Asn Gly Tyr Ile Gly Leu Ala Lys Gln Val Pro Ile Phe Glu 
                85                  90                  95      


Ser Met Gly Ile Glu Asp Pro Gln Ser Phe Ala Asn Leu Met Trp Pro 
            100                 105                 110         


Asn Gly Asn Asp Glu Phe Ser Lys Cys Ile Lys Ile Tyr Ser Asp Lys 
        115                 120                 125             


Leu Thr Glu Leu Asp Glu Ile Val Arg Thr Met Val Leu Glu Ser Leu 
    130                 135                 140                 


Asn Leu Glu Lys Tyr Met Asp Glu His Met Glu Leu Thr Ser Tyr Ile 
145                 150                 155                 160 


Thr Arg Val Met Lys Tyr Arg Val Pro Gln Lys Asp Glu Pro Asn Ala 
                165                 170                 175     


Gly Leu Leu Ser His Ala Asp Lys Asn Ile Val Thr Ile Leu His Glu 
            180                 185                 190         


Phe Gly Val Glu Gly Leu Glu Val Gln Thr Lys Asp Gly Glu Trp Phe 
        195                 200                 205             


Lys Val Lys Leu Ser Ala Asn Ser Phe Val Val Met Val Gly Glu Ala 
    210                 215                 220                 


Phe Lys Val Leu Thr Asn Gly Arg Leu Arg Pro Ala Val His Arg Val 
225                 230                 235                 240 


Val Met Ser Gly Asp Glu Asp Arg Phe Ser Ile Gly Val Phe Ser Val 
                245                 250                 255     


Pro Lys Asp Glu Lys Thr Ile Lys Ala Pro Glu Glu Met Val Asp Glu 
            260                 265                 270         


Asp His Pro Leu Leu Phe Lys Pro Phe Val Tyr Glu Glu Phe Phe Lys 
        275                 280                 285             


Phe Phe Arg Leu Glu Glu Asn Val Asn Asp Pro Leu Ala Leu Glu Lys 
    290                 295                 300                 


Tyr Cys Gly Val Ser Thr Glu Asn Leu 
305                 310             


<210>  313
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  313

Met Ala Ala Val Ser Lys Arg Leu Leu Val Ser Asp Leu Val Thr Phe 
1               5                   10                  15      


Asp Lys Ile Asn Gln Val Pro Ser Asn Tyr Ile Arg Pro Leu Ser Glu 
            20                  25                  30          


Arg Pro Asn Leu Gln His Val Ser Ser His Glu Thr Ile Pro Ile Ile 
        35                  40                  45              


Asp Leu His Asp Leu Asn Ser Ala Lys Arg Arg His Val Ile Asn Gln 
    50                  55                  60                  


Ile Arg Asp Ala Cys Arg Glu Tyr Gly Phe Phe Gln Val Lys Asn His 
65                  70                  75                  80  


Ser Val Pro Glu Ser Thr Ile Thr Asn Met Met Gln Ile Ala Lys Asp 
                85                  90                  95      


Phe Phe Ser Leu Pro Glu Glu Glu Arg Leu Lys Ser Tyr Ser Asp Asp 
            100                 105                 110         


Pro Ser Lys Thr Thr Arg Leu Ser Thr Ser Phe Asn Ile Arg Thr Glu 
        115                 120                 125             


Lys Val Ala Asn Trp Arg Asp Phe Leu Arg Leu His Cys Tyr Pro Leu 
    130                 135                 140                 


Glu Asp Tyr Val His Glu Trp Pro Thr Asn Pro Ser Ser Phe Arg Ala 
145                 150                 155                 160 


His Val Lys Glu Tyr Cys Thr Ser Val Arg Gly Leu Ala Leu Glu Leu 
                165                 170                 175     


Val Glu Ala Ile Ser Glu Ser Leu Gly Leu Glu Arg Asp Tyr Ile Gly 
            180                 185                 190         


Lys Gln Leu Gly Lys His Gly Gln His Met Ala Leu Asn Tyr Tyr Pro 
        195                 200                 205             


Pro Cys Pro Gln Pro Asp Leu Thr Tyr Gly Leu Pro Gly His Thr Asp 
    210                 215                 220                 


Leu Asn Leu Ile Thr Ile Leu Leu Gln Asp Asp Val Pro Gly Leu Gln 
225                 230                 235                 240 


Val Leu Lys Asp Gly Lys Trp Val Ala Val Asp Pro Val Pro Asn Thr 
                245                 250                 255     


Phe Ile Ile Asn Ile Gly Asp Gln Ile Gln Val Leu Ser Asn Asp Lys 
            260                 265                 270         


Tyr Lys Ser Ile Leu His Arg Ala Val Val Asn Cys Asp Lys Glu Arg 
        275                 280                 285             


Ile Ser Ile Pro Thr Phe Tyr Cys Pro Ser Arg Asp Ala Val Ile Ser 
    290                 295                 300                 


Pro Ala Pro Glu Leu Val Thr Glu Asp Gln Pro Ala Val Tyr Arg Pro 
305                 310                 315                 320 


Phe Thr Tyr Gly Glu Tyr Tyr Asp Lys Phe Trp Asn Arg Gly Leu Ala 
                325                 330                 335     


Thr Glu Asn Cys Leu Asp Met Phe Met Ala Thr Lys Ser Thr 
            340                 345                 350 


<210>  314
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  314

Met Pro Thr Ile Asp Ser Lys Ser Leu Asn Ile Leu Asp Phe Val Val 
1               5                   10                  15      


Asn Gln Gly His Gly Val Lys Gly Leu Ala Glu Leu Gly Leu Glu Thr 
            20                  25                  30          


Leu Pro Tyr Gln Tyr Ile Gln Pro Pro Gln Glu Arg Phe Asn Thr Ser 
        35                  40                  45              


His Glu Glu Asp Asn Lys Asp Ser Ile Pro Val Ile Asp Met Ser Asn 
    50                  55                  60                  


Ser Asn Asp Pro His Val Ala Lys Ala Ile Cys Asp Ala Ala Gln Lys 
65                  70                  75                  80  


Trp Gly Phe Phe Gln Ile Val Asn His Gly Val Pro Thr His Val Leu 
                85                  90                  95      


Glu Asp Val Lys Asp Ala Thr His Lys Phe Phe Ala Leu Pro Pro Gln 
            100                 105                 110         


Glu Lys Leu Lys Tyr Ser Lys Glu Gln Ser Val Thr His Asn Val Arg 
        115                 120                 125             


Phe Gly Thr Ser Phe Thr Pro Glu Ala Glu Lys Ala Leu Glu Trp Lys 
    130                 135                 140                 


Asp Tyr Leu Ser Leu Phe Phe Val Ser Asp Thr Glu Ala Ala Ser Leu 
145                 150                 155                 160 


Trp Pro Pro Thr Cys Arg Asp Gln Ala Met Glu Tyr Ile Lys Ser Ser 
                165                 170                 175     


Glu Leu Leu Val Lys Lys Leu Leu Asn Ile Leu Met Asn Gly Leu Asn 
            180                 185                 190         


Val Lys Glu Ile Asp Glu Thr Lys Glu Ser Ile Leu Met Gly Ser Lys 
        195                 200                 205             


Arg Ile Asn Leu Asn Tyr Tyr Pro Lys Cys Pro Ser Pro Glu Leu Thr 
    210                 215                 220                 


Val Gly Val Gly Arg His Ser Asp Val Ser Thr Leu Thr Ile Leu Leu 
225                 230                 235                 240 


Gln Asp Asp Ile Gly Gly Leu Phe Val Arg Asn Met Glu Thr Met Lys 
                245                 250                 255     


Trp Ile His Val Pro Pro Val Ser Gly Ser Leu Val Ile Asn Val Gly 
            260                 265                 270         


Asp Ala Leu Gln Ile Met Ser Asn Gly Lys Tyr Lys Ser Val Glu His 
        275                 280                 285             


Arg Val Thr Ala Asn Gly Ser Asn Asn Arg Ile Ser Val Pro Ile Phe 
    290                 295                 300                 


Val Asn Pro Lys Pro Ser Asp Val Ile Gly Pro Leu Glu Glu Val Ile 
305                 310                 315                 320 


Ala Ser Gly Glu Glu Pro Leu Tyr Lys Asn Val Leu Tyr Ser Asp Tyr 
                325                 330                 335     


Val Lys His Phe Phe Arg Lys Ala His Asp Gly Lys Ala Thr Val Glu 
            340                 345                 350         


Phe Ala Lys Ile 
        355     


<210>  315
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  315

Met Gly Ser Leu Ser Gln Pro Lys Leu Pro Val Ile Asn Leu Ser Ala 
1               5                   10                  15      


Lys Asn Leu Glu Tyr Asn Ser Ile Ser Trp Val Lys Thr Cys Gly Glu 
            20                  25                  30          


Val Ile Ser Ala Leu Glu Lys Tyr Gly Cys Phe Val Ala Lys Tyr Asp 
        35                  40                  45              


Gly Val Ser Gln Glu Leu His Asp Ala Ile Phe His Ala Ser His Asp 
    50                  55                  60                  


Leu Phe Asp Leu Pro Thr Glu Val Lys Val Leu Asn Thr Ser Asp Thr 
65                  70                  75                  80  


Pro Ser His Gly Tyr Val Gly Gln Ile Pro Val Ile Pro Leu Tyr Glu 
                85                  90                  95      


Gly Leu Gly Val Glu Asn Ala Thr Thr Ala Asp Gly Val Glu Arg Phe 
            100                 105                 110         


Thr Lys Leu Met Trp Pro Ser Gly Asn Gly Val Phe Cys Glu Thr Val 
        115                 120                 125             


Leu Met Phe Ser Lys Ala Val Ala Glu Leu Asp Gln Ile Val Met Lys 
    130                 135                 140                 


Met Ile Ala Lys Ser Tyr Gly Ile Glu Glu His Tyr Gly Pro Leu Leu 
145                 150                 155                 160 


Gly Ser Thr Thr Tyr Leu Leu Lys Leu Ile Lys Tyr Leu Ser Pro Gln 
                165                 170                 175     


Gly Asp Glu Arg Asn Leu Gly Ile Val Pro His Thr Asp Lys Thr Phe 
            180                 185                 190         


Met Ser Ile Leu His Gln Asp Glu Val Lys Gly Leu Glu Ile Lys Thr 
        195                 200                 205             


Lys Asp Gly Glu Trp Ile Lys Tyr Asp Pro Ser Pro Ser Ser Phe Val 
    210                 215                 220                 


Val Met Ala Gly Asp Gly Cys Met Ala Trp Thr Asn Gly Lys Ile Glu 
225                 230                 235                 240 


Ala Ser Cys His Arg Val Met Met Gln Gly Ser Lys Glu Arg Phe Ser 
                245                 250                 255     


Leu Gly Leu Phe Thr Phe Ile Arg Asn Ile Lys Ile Glu Thr Pro Gln 
            260                 265                 270         


Glu Leu Val Asp Glu Asn Asn Pro Pro Lys Phe Lys Ala Phe Asp His 
        275                 280                 285             


Tyr Lys Tyr Leu His Tyr His Ala Thr Asp Glu Gly Met Arg Ser Lys 
    290                 295                 300                 


Phe Pro Leu Lys Ser Tyr Cys Gly Ile 
305                 310             


<210>  316
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  316

Met Ala Asn Phe Pro Ile Ile Asn Met Glu Thr Leu Asp Gly Asp Glu 
1               5                   10                  15      


Arg Cys Ala Thr Met Ala Lys Ile Gln Asp Ala Cys Glu Asn Trp Gly 
            20                  25                  30          


Phe Phe Glu Val Leu Asn His Gly Ile Ser His Glu Leu Leu Asp Lys 
        35                  40                  45              


Val Glu Thr Met Thr Lys Glu His Tyr Lys Lys Cys Met Glu Gln Arg 
    50                  55                  60                  


Phe Lys Asp Met Val Ala Glu Lys Ala Leu Glu Gly Val Lys Ala Glu 
65                  70                  75                  80  


Val Thr Asp Ile Asp Trp Glu Ser Thr Phe Phe Leu Arg His Leu Pro 
                85                  90                  95      


Thr Ser Asn Ile Ser Glu Val Pro Asp Leu Glu Asp Glu Tyr Arg Glu 
            100                 105                 110         


Leu Met Lys Asp Phe Ala Ala Lys Leu Glu Lys Leu Ala Glu Glu Leu 
        115                 120                 125             


Leu Asp Ile Leu Cys Glu Asn Leu Gly Leu Glu Lys Gly Tyr Leu Lys 
    130                 135                 140                 


Lys Ala Phe Tyr Gly Ser Lys Gly Pro Asn Phe Gly Thr Lys Val Ser 
145                 150                 155                 160 


Asn Tyr Pro Pro Cys Pro Thr Pro Asp Leu Ile Lys Gly Leu Arg Ala 
                165                 170                 175     


His Thr Asp Ala Gly Gly Ile Ile Leu Leu Phe Gln Asp Asp Lys Val 
            180                 185                 190         


Ser Gly Leu Gln Leu Leu Lys Asp Gly Glu Trp Val Asp Val Pro Pro 
        195                 200                 205             


Met Arg His Ser Ile Val Ile Asn Leu Gly Asp Gln Ile Glu Val Ile 
    210                 215                 220                 


Thr Asn Gly Lys Tyr Lys Ser Val Met His Arg Val Ile Ala Gln Thr 
225                 230                 235                 240 


Asp Gly Thr Arg Met Ser Leu Ala Ser Phe Tyr Asn Pro Gly Asn Asp 
                245                 250                 255     


Ala Val Ile Tyr Pro Ala Pro Ala Leu Leu Glu Lys Glu Pro Lys Glu 
            260                 265                 270         


Asn Glu Gln Ser Tyr Pro Lys Phe Val Phe Asp Asp Tyr Met Lys Leu 
        275                 280                 285             


Tyr Ala Gly Leu Lys Phe Gln Ala Lys Glu Pro Arg Phe Glu Ala Met 
    290                 295                 300                 


Lys Ala Val Glu Ala Asn Val Ala Ala 
305                 310             


<210>  317
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  317

Met Gly Thr Leu Pro Gln Ala Lys His Leu Pro Val Ile Asp Leu Arg 
1               5                   10                  15      


Leu Glu His Leu Asn Ser Thr Ser Ser Thr Trp Val Thr Thr Cys Gly 
            20                  25                  30          


Glu Val Met Arg Ala Leu Glu Glu Tyr Gly Cys Phe Ile Ala Met Tyr 
        35                  40                  45              


Asp Gly Val Ser Gln Gly Leu His Asp Ala Ile Phe His Ala Ser Gln 
    50                  55                  60                  


Gln Leu Phe Asp Leu Pro Thr Glu Val Lys Ala Leu Asp Thr Ala Tyr 
65                  70                  75                  80  


Pro Pro Ser His Gly Tyr Ile Gly Ala Arg Pro Gly Ala Pro Phe Tyr 
                85                  90                  95      


Glu Gly Leu Gly Ile Gln Asn Ala Thr Thr Lys Gln Gly Ile Glu Arg 
            100                 105                 110         


Phe Glu Lys Leu Met Trp Pro Ser Gly Asn Pro Ser Phe Ser Glu Gly 
        115                 120                 125             


Val Leu Glu Tyr Ser Lys Ala Val Ala Glu Leu Glu His Leu Val Met 
    130                 135                 140                 


Arg Ile Ile Ala Lys Ser Tyr Gly Ile Glu Glu Asn Tyr Glu Ser Leu 
145                 150                 155                 160 


Leu Gly Ser Lys Thr Tyr Leu Val Arg Leu Met Lys Tyr Ile Ile Pro 
                165                 170                 175     


Gln Val Lys Glu Asn Glu Ser Ile Ile Gly Ile Tyr Ala His Thr Asp 
            180                 185                 190         


Lys Thr Phe Thr Ser Leu Leu Asp Gln Tyr Gln Val Lys Gly Leu Glu 
        195                 200                 205             


Ile Lys Ala Lys Asp Gly Glu Trp Ile Glu Val Asn Pro Leu Pro Ser 
    210                 215                 220                 


Ser Phe Val Phe Met Ala Gly Asp Val Cys Thr Ala Trp Thr Asn Gly 
225                 230                 235                 240 


Arg Ile Glu Ser Pro Val His Arg Val Met Met His Gly Asp Lys Glu 
                245                 250                 255     


Arg Tyr Ser Val Gly Ile Tyr Ala Phe Ile Arg Asp Arg Lys Ile Glu 
            260                 265                 270         


Val Pro Gln Gln Leu Val Asp Glu Asp His Pro Leu Gln Tyr Lys Pro 
        275                 280                 285             


Phe Tyr Asn Cys Lys Leu Ile Asp Tyr Phe Asn Thr Asp Glu Gly Lys 
    290                 295                 300                 


Lys Ser Lys Tyr Pro Leu Lys Ser Phe Cys Gly Ile 
305                 310                 315     


<210>  318
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  318

Met Ala Ala Lys Val Ile Ser Ser Gly Phe Arg Tyr Thr Ser Leu Pro 
1               5                   10                  15      


Glu Ser Tyr Val Arg Pro Val Thr Asp Arg Pro Asn Leu Ser Gln Val 
            20                  25                  30          


Ser Glu Cys Asp Asp Val Pro Val Ile Asp Ile Gly Cys Gly Asp Arg 
        35                  40                  45              


Glu Leu Ile Ser Lys Gln Ile Gly Asp Ala Cys Arg His Tyr Gly Phe 
    50                  55                  60                  


Phe Gln Val Ile Asn His Gly Val Pro Asp Glu Ile Val Lys Lys Met 
65                  70                  75                  80  


Gln Gln Val Gly Arg Asp Phe Phe Glu Leu Pro Leu Glu Glu Lys Met 
                85                  90                  95      


Lys Leu Tyr Ser Glu Asp Pro Thr Lys Thr Met Arg Leu Ser Thr Ser 
            100                 105                 110         


Phe Asn Val Gln Lys Glu Lys Val His Asn Trp Arg Asp Tyr Leu Arg 
        115                 120                 125             


Leu His Cys His Pro Leu Asp Lys Tyr Ser Pro Glu Trp Pro Ser Asn 
    130                 135                 140                 


Pro Ala Tyr Phe Lys Glu Tyr Val Gly Asn Tyr Val Thr Ala Val Arg 
145                 150                 155                 160 


Asp Leu Gly Met Arg Val Leu Glu Ser Ile Ser Glu Ser Leu Gly Leu 
                165                 170                 175     


Glu Lys Asp Arg Ile Ile Lys Ile Leu Gly Asp Gln Gly Gln His Met 
            180                 185                 190         


Ala Ile Asn His Tyr Pro Val Cys Pro Glu Pro Glu Leu Thr Phe Gly 
        195                 200                 205             


Leu Pro Gly His Thr Asp Pro Asn Ala Leu Thr Ile Leu Leu Gln Asp 
    210                 215                 220                 


Thr Leu Val Ser Gly Leu Gln Val Leu Lys Asp Gly Lys Trp Val Ala 
225                 230                 235                 240 


Val Lys Pro His Pro Asn Ala Phe Val Ile Asn Ile Gly Asp Gln Leu 
                245                 250                 255     


Glu Ala Val Ser Asn Gly Gln Tyr Lys Ser Val Trp His Arg Ala Val 
            260                 265                 270         


Val Asn Ser Asp Lys Pro Arg Met Ser Ile Ala Ser Phe Leu Cys Pro 
        275                 280                 285             


Cys Asn Asp Ser Ile Leu Ser Ala Pro Lys Glu Leu Ile Lys Asp Gly 
    290                 295                 300                 


Ser Lys Pro Val Phe Lys Asp Phe Thr Tyr Ala Glu Tyr Tyr Lys Lys 
305                 310                 315                 320 


Phe Trp Ser Arg Asn Leu Asp Gln Glu Gln His Cys Leu Glu Phe Phe 
                325                 330                 335     


Lys Asn 
        


<210>  319
<211>  1016
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  319

Met Gly Ser Glu Ser His Ile Arg Leu Pro Val Ile Asp Phe Ser Pro 
1               5                   10                  15      


Leu Thr His Ile Ser Asn Asp Ala Ser Ile Trp Glu Ser Ile Arg Ala 
            20                  25                  30          


Asp Val Phe Lys Thr Ile Gln His Tyr Gly Cys Phe Glu Val Ser Ser 
        35                  40                  45              


Phe Val Ser Ile Asp Leu Gln Glu Ser Val Asn Ala Gly Leu Lys Gln 
    50                  55                  60                  


Leu Phe Asp Leu Pro Leu Glu Thr Lys Ala Lys Asn Thr Ser Glu Ile 
65                  70                  75                  80  


Ala Phe His Gly Tyr Val Arg Ser Pro Lys Val Pro Leu Tyr Glu Ser 
                85                  90                  95      


Met Gly Ile Gly Asn Pro Phe Ile Thr Glu Asn Val Asp Ser Phe Thr 
            100                 105                 110         


Asn Leu Met Trp Pro Gln Asp Asn Pro Lys Phe Arg Ala Met Leu Phe 
        115                 120                 125             


Val Asp Asn Phe Leu Arg Arg Tyr Leu Lys Phe Val Thr Ser Thr Ser 
    130                 135                 140                 


Ile Val Pro His Asn Thr Thr Ser Met Lys Met Gly Ser Glu Ser His 
145                 150                 155                 160 


Ile Arg Leu Pro Val Ile Asp Phe Ser Pro Leu Thr His Ile Ser Asn 
                165                 170                 175     


Asp Ala Ser Ile Trp Glu Ser Ile Arg Ala Asp Val Phe Lys Ala Ile 
            180                 185                 190         


Gln Asp Asn Gly Cys Phe Glu Val Ser Ser Phe Val Ser Ile Asp Leu 
        195                 200                 205             


Gln Glu Ser Val Asn Ala Gly Leu Lys Gln Leu Phe Asp Leu Pro Leu 
    210                 215                 220                 


Glu Thr Lys Ala Lys Asn Thr Ser Glu Ile Ala Phe His Gly Tyr Val 
225                 230                 235                 240 


Arg Ser Pro Lys Val Pro Leu Tyr Glu Ser Met Gly Ile Gly Asn Pro 
                245                 250                 255     


Phe Ile Thr Glu Asn Val Asp Asn Phe Thr Asn Leu Met Trp Pro Gln 
            260                 265                 270         


Asp Asn Pro Lys Phe Arg Glu Ser Ile Met Thr Tyr Ser Arg Lys Leu 
        275                 280                 285             


Arg Glu Leu Asp Glu Ile Val Lys Arg Met Val Phe Glu Ser Leu Asp 
    290                 295                 300                 


Leu Glu Lys Tyr Leu Gly Glu Gln Met Lys Ser Thr Ser Tyr Leu Leu 
305                 310                 315                 320 


Lys Leu Met Lys Tyr Arg Ala Pro Glu Pro Asn Glu Ser Asp Ile Gly 
                325                 330                 335     


Leu His Thr His Thr Asp Thr Asn Ile Met Thr Ile Leu His Gln Asp 
            340                 345                 350         


Glu Ile Gly Gly Leu Glu Ile Gln Thr Lys Asn Asp Glu Trp Ile Arg 
        355                 360                 365             


Val Lys Val Ser Pro Asn Ser Phe Val Val Val Ala Gly Glu Thr Phe 
    370                 375                 380                 


Asn Phe Arg Ala Met Leu Phe Val Asp Asn Phe Leu Arg Arg Tyr Leu 
385                 390                 395                 400 


Lys Phe Val Thr Ser Thr Ser Ile Val Pro His Asn Thr Thr Ser Met 
                405                 410                 415     


Lys Met Gly Ser Glu Ser His Ile Arg Leu Pro Val Ile Asp Phe Ser 
            420                 425                 430         


Pro Leu Thr His Ile Ser Asn Asp Ala Ser Ile Trp Glu Ser Ile Arg 
        435                 440                 445             


Ala Asp Val Phe Lys Ala Ile Gln Asp Asn Gly Cys Phe Glu Val Ser 
    450                 455                 460                 


Ser Phe Val Ser Ile Asp Leu Gln Glu Ser Val Asn Ala Gly Leu Lys 
465                 470                 475                 480 


Gln Leu Phe Asp Leu Pro Leu Glu Thr Lys Ala Lys Asn Thr Ser Glu 
                485                 490                 495     


Ile Ala Phe His Gly Tyr Val Arg Ser Pro Lys Val Pro Leu Tyr Glu 
            500                 505                 510         


Ser Met Gly Ile Gly Asn Pro Phe Ile Thr Glu Asn Val Asp Asn Phe 
        515                 520                 525             


Thr Asn Leu Met Trp Pro Gln Asp Asn Pro Lys Phe Arg Glu Ser Ile 
    530                 535                 540                 


Met Thr Tyr Ser Arg Lys Leu Arg Glu Leu Asp Glu Ile Val Lys Arg 
545                 550                 555                 560 


Met Val Phe Glu Ser Leu Asp Leu Glu Lys Tyr Leu Gly Glu Gln Met 
                565                 570                 575     


Lys Ser Thr Ser Tyr Leu Leu Lys Leu Met Lys Tyr Arg Ala Pro Glu 
            580                 585                 590         


Pro Asn Glu Ser Asp Ile Gly Leu His Thr His Thr Asp Thr Asn Ile 
        595                 600                 605             


Met Thr Ile Leu His Gln Asp Glu Ile Gly Gly Leu Glu Ile Gln Thr 
    610                 615                 620                 


Lys Asn Asp Glu Trp Ile Arg Val Lys Val Ser Pro Asn Ser Phe Val 
625                 630                 635                 640 


Val Val Ala Gly Glu Thr Phe Asn Val Trp Leu Asn Gly Arg Leu His 
                645                 650                 655     


Val Pro Phe His Arg Val Val Met Thr Gly Asn Met Ala Arg Tyr Ser 
            660                 665                 670         


Leu Gly Phe Phe Ser Val Gln Lys Ser Ser Ser Phe Val Lys Ser Phe 
        675                 680                 685             


Asp Glu Met Val Asp Glu Glu His Pro Leu Leu Tyr Lys Pro Phe Gln 
    690                 695                 700                 


Tyr Gly Glu Phe Leu Lys Phe Phe Tyr Lys Glu Gly Gly Ile Lys Thr 
705                 710                 715                 720 


Asn Lys Lys Leu Asp Val Glu Val Leu Glu Lys Ser Val Ile Ile Lys 
                725                 730                 735     


Leu Ile Cys Asp Lys Val Arg Pro Arg Leu Met Ser Leu Lys Thr Lys 
            740                 745                 750         


Lys Ser Asn Ala Val Lys Ala Thr Glu Lys Ala Trp Glu Met Leu Arg 
        755                 760                 765             


Phe Gln Asp Ile Phe Thr Ile Pro Trp Asn Ala Lys Met Glu Phe Lys 
    770                 775                 780                 


Gly Thr Lys Ala Ala Tyr Asp Thr Trp Gly Val Gly Met Gly Asn Ser 
785                 790                 795                 800 


Val Ile Asn Thr Ser Ala Asp Cys Lys Gly Ser Ile Cys Asn Ile Val 
                805                 810                 815     


Thr Cys Asn His Leu Phe Leu Gly Lys Gly Ala Ile Pro Arg Tyr His 
            820                 825                 830         


Thr Ser Ile Lys Ala Ala Pro Tyr Glu Thr Leu Tyr Gly Arg Lys Cys 
        835                 840                 845             


Arg Ser Pro Ile Cys Trp Ala Glu Val Gly Glu Ser Gln Leu Thr Gly 
    850                 855                 860                 


Pro Asp Leu Val His Glu Thr Thr Glu Lys Ile Val Gln Ile Lys Asn 
865                 870                 875                 880 


Arg Met Gln Ala Ala Arg Asp Arg Gln Lys Ser Tyr Ala Asp Lys Arg 
                885                 890                 895     


Arg Lys Pro Leu Glu Phe Gln Val Gly Asp Lys Val Met Leu Lys Val 
            900                 905                 910         


Ser Pro Trp Lys Gly Val Ile Arg Phe Gly Lys His Glu Lys Leu Asn 
        915                 920                 925             


Pro Arg Tyr Ile Gly Pro Phe Glu Ile Leu Ala Arg Val Gly Pro Val 
    930                 935                 940                 


Ala Asp Arg Leu Ala Leu Pro Ser Glu Leu Ser Ala Val His Asn Val 
945                 950                 955                 960 


Phe His Val Cys Asn Leu Lys Lys Cys Leu Ser Asp Asp Asp Ser Ala 
                965                 970                 975     


Ile Pro Leu Glu Glu Ile Gln Val Asp Glu Arg Leu Asn Phe Val Glu 
            980                 985                 990         


Glu Pro Ile Glu Ile Met Asp Arg  Glu Val Lys Arg Leu  Lys Gln Ser 
        995                 1000                 1005             


Arg Ile  Pro Ile Val Lys Val  Arg 
    1010                 1015     


<210>  320
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  320

Met Ala Pro Val Leu Glu Phe Pro Leu Asn Val Gly Gln Ile Asp Asp 
1               5                   10                  15      


Val Gln Glu Leu Lys Lys Ser Gln Lys Thr Lys Ile Pro Asn Arg Phe 
            20                  25                  30          


Val Arg Asp Leu Ser Glu Arg Pro Met Leu Pro Ile Thr Ala Leu Pro 
        35                  40                  45              


Phe Ser Ser Ser Ile Pro Val Ile Asp Leu Ala Lys Leu Met Lys Gly 
    50                  55                  60                  


Asn Lys Glu Glu Phe His Tyr Glu Ile Leu Lys Leu Ser Ala Ser Cys 
65                  70                  75                  80  


Glu Glu Trp Gly Phe Phe Gln Val Ile Asn His Glu Ile Asn Leu Asp 
                85                  90                  95      


Leu Leu Asp Lys Ile Glu Lys Val Ala Thr Glu Phe Phe Met Leu Pro 
            100                 105                 110         


Val Glu Glu Lys Gln Lys Tyr Pro Met Ala Pro Gly Thr Val Gln Gly 
        115                 120                 125             


Tyr Gly Gln Ala Phe Val Phe Ser Glu Asp Gln Lys Leu Asp Trp Cys 
    130                 135                 140                 


Asn Met Phe Ala Leu Gly Leu Val Pro His Ser Ile Arg Asn Pro Lys 
145                 150                 155                 160 


Leu Trp Pro Thr Asn Pro Pro Met Phe Ser Asp Thr Val Glu Thr Tyr 
                165                 170                 175     


Ser Thr Glu Ile Arg Lys Leu Cys Lys His Leu Leu Gln Phe Ile Ala 
            180                 185                 190         


Leu Ser Leu Gly Leu Asn Gly Asn Val Phe Glu Glu Met Phe Gly Glu 
        195                 200                 205             


Ser Val Gln Ala Ile Arg Met Asn Tyr Tyr Pro Ala Cys Pro Arg Pro 
    210                 215                 220                 


Asp Leu Val Leu Gly Leu Ser Pro His Ser Asp Gly Ser Ala Leu Thr 
225                 230                 235                 240 


Val Leu Gln Gln Gly Lys Gly Asn Ala Val Gly Leu Gln Ile Leu Lys 
                245                 250                 255     


Asn Asn Thr Trp Val Pro Ile Gln Pro Val Pro Asn Ala Leu Val Ile 
            260                 265                 270         


Asn Ile Gly Asp Thr Val Glu Val Leu Thr Asn Gly Arg Tyr Lys Ser 
        275                 280                 285             


Ser Glu His Arg Ala Val Thr His Lys Gln Lys Asp Arg Leu Ser Ile 
    290                 295                 300                 


Val Thr Phe Tyr Ala Pro Ser Tyr Asp Ile Glu Ile Gly Pro Met Pro 
305                 310                 315                 320 


Glu Met Val Asp Glu Arg Ser Pro Ser Lys Tyr Arg Arg Tyr Asn His 
                325                 330                 335     


Gly Glu Tyr Ser Arg His Tyr Val Thr Asn Lys Leu Gln Gly Lys Lys 
            340                 345                 350         


Thr Leu Asp Phe Ala Lys Ile Ala Pro Glu Thr Val 
        355                 360                 


<210>  321
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  321

Met Gly Ser Leu Pro Lys Ala Lys Gln Leu Pro Val Ile Asp Leu Cys 
1               5                   10                  15      


Leu Asn Asn Leu Asp Ser Ser Ser Ser Ser Trp Val Arg Lys Cys Asp 
            20                  25                  30          


Glu Val Thr Arg Ala Leu Glu Glu Tyr Gly Cys Phe Ile Ala Val Tyr 
        35                  40                  45              


Asp Gly Val Ser Gln Glu Leu Tyr Asp Ala Thr Val Val Ala Ser Gln 
    50                  55                  60                  


Glu Val Phe Asp Leu Pro Ile Gln Lys Lys Val Leu Asn Ser Arg Asp 
65                  70                  75                  80  


Ala Ala Gly His Gly Tyr Leu Gly Gln Leu Pro Thr Met Pro Leu Phe 
                85                  90                  95      


Glu Arg Leu Ser Ile Glu Asn Ala Thr Thr Pro Gln Gly Ala Glu Thr 
            100                 105                 110         


Phe Thr Lys Leu Met Trp Pro Ser Gly Asn Pro Ser Phe Cys Glu Ser 
        115                 120                 125             


Ala Leu Ala Phe Ala Lys Val Leu Ala Glu Leu Glu Val Ile Val Met 
    130                 135                 140                 


Arg Met Val Ala Lys Ser Leu Gly Ile Glu Gln Asp Tyr Glu Lys Leu 
145                 150                 155                 160 


Gln Glu Ser Thr Thr Tyr Ile Phe Lys Phe Asn Lys Tyr Leu Ser Pro 
                165                 170                 175     


Pro Gly Gly Glu Lys Thr Val Gly Ile Val Ser His Thr Asp Lys Gly 
            180                 185                 190         


Phe Met Thr Ile Ile Gln Gln Gln Glu Asp Gly Lys Gly Leu Glu Ile 
        195                 200                 205             


Lys Thr Lys Asp Gly Glu Trp Ile Glu Val Glu Phe Lys Pro Ser Ser 
    210                 215                 220                 


Phe Ile Val Met Ala Gly Asp Val Cys Thr Ala Trp Ser Asn Gly Arg 
225                 230                 235                 240 


Ile Glu Ala Pro Ser His Arg Val Met Met Glu Gly His Lys Asn Arg 
                245                 250                 255     


Ile Ser Leu Val Thr Ser Ser Phe Ile Arg Asp Gln Val Glu Val Pro 
            260                 265                 270         


Gln Gly Leu Val Ser Glu His His Pro Leu Lys Phe Lys Ala Phe Asp 
        275                 280                 285             


His Tyr Lys Tyr Ile Glu Tyr His Asn Ser Thr Thr Asp Ala Asn Arg 
    290                 295                 300                 


Asn Arg Leu Glu Asp Ala Ile Arg Phe Tyr Cys Gly Ile 
305                 310                 315         


<210>  322
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  322

Met Ala Ala Lys Val Ile Ser Ser Gly Phe Arg Tyr Thr Ser Leu Pro 
1               5                   10                  15      


Glu Ser Tyr Val Arg Pro Val Thr Asp Arg Pro Asn Leu Ser Gln Val 
            20                  25                  30          


Ser Glu Cys Asp Asp Val Pro Val Ile Asp Ile Gly Cys Gly Asp Arg 
        35                  40                  45              


Glu Leu Ile Ser Lys Gln Ile Gly Asp Ala Cys Arg His Tyr Gly Phe 
    50                  55                  60                  


Phe Gln Val Ile Asn His Gly Val Pro Asp Glu Ile Val Lys Lys Met 
65                  70                  75                  80  


Gln Gln Val Gly Arg Asp Phe Phe Glu Leu Pro Leu Glu Glu Lys Met 
                85                  90                  95      


Lys Leu Tyr Ser Glu Asp Pro Thr Lys Thr Met Arg Leu Ser Thr Ser 
            100                 105                 110         


Phe Asn Val Gln Lys Glu Lys Val His Asn Trp Arg Asp Tyr Leu Arg 
        115                 120                 125             


Leu His Cys His Pro Leu Asp Lys Tyr Ser Pro Glu Trp Pro Ser Asn 
    130                 135                 140                 


Pro Ala Tyr Phe Lys Glu Tyr Val Gly Asn Tyr Val Thr Ala Val Arg 
145                 150                 155                 160 


Asp Leu Gly Met Arg Val Leu Glu Ser Ile Ser Glu Ser Leu Gly Leu 
                165                 170                 175     


Gln Lys Asp Arg Ile Ile Lys Ile Leu Gly Asp Gln Gly Gln His Met 
            180                 185                 190         


Ala Ile Asn His Tyr Pro Val Cys Pro Glu Pro Glu Leu Thr Phe Gly 
        195                 200                 205             


Leu Pro Gly His Thr Asp Pro Asn Ala Leu Thr Ile Leu Leu Gln Asp 
    210                 215                 220                 


Thr Leu Val Ser Gly Leu Gln Val Leu Lys Asp Gly Lys Trp Val Ala 
225                 230                 235                 240 


Val Lys Pro His Pro Asn Ala Phe Val Ile Asn Ile Gly Asp Gln Leu 
                245                 250                 255     


Glu Ala Val Ser Asn Gly Gln Tyr Lys Ser Val Trp His Arg Ala Val 
            260                 265                 270         


Val Asn Ser Asp Lys Pro Arg Met Ser Ile Ala Ser Phe Leu Cys Pro 
        275                 280                 285             


Cys Asn Asp Ser Ile Leu Ser Ala Pro Lys Glu Leu Ile Lys Asp Gly 
    290                 295                 300                 


Ser Lys Pro Val Phe Lys Asp Phe Thr Tyr Ala Glu Tyr Tyr Lys Lys 
305                 310                 315                 320 


Phe Trp Ser Arg Asn Leu Asp Gln Glu Gln His Cys Leu Glu Phe Phe 
                325                 330                 335     


Lys Asn 
        


<210>  323
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  323

Met Arg Met Pro Arg Glu Gly Val Pro Val Ile Asp Met Lys Lys Leu 
1               5                   10                  15      


Asp Thr Leu Ser Met Glu Ile Val Lys Ala Ser Glu Glu Trp Gly Cys 
            20                  25                  30          


Phe Arg Ile Val Asn His Gly Val Ser Ile Asp Leu Met Ala Glu Met 
        35                  40                  45              


Lys Ala Val Val Ala Ser Leu Phe Asp Gln Pro Glu Glu Ile Lys Met 
    50                  55                  60                  


Arg Thr Val His Thr Glu Val Gly Lys Gly Tyr Val Lys Arg Asn Leu 
65                  70                  75                  80  


Ala Gly Pro Cys Phe Glu Gly Phe Ser Ile Asp Asp Ile Ser Leu Pro 
                85                  90                  95      


Gly Glu Phe Cys Asp Arg Ile Asn Ala Ser Val His Gln Arg Lys Ile 
            100                 105                 110         


Ile Asn Lys Tyr Ile Lys Ala Ile Arg Asp Leu Ala Arg Leu Leu Gly 
        115                 120                 125             


Leu Lys Leu Met Glu Gly Cys Gly Leu Asn Gly Asp Leu Phe Asp Gly 
    130                 135                 140                 


Trp Cys Cys Gln Leu Arg Met Asn Lys Tyr His Phe Cys Pro Lys Ser 
145                 150                 155                 160 


Ile Gly Ser Thr Gly Val Pro Ile His Thr Asp Pro Thr Phe Leu Thr 
                165                 170                 175     


Ile Leu Gln Asp Asp Glu Asn Val Asn Gly Leu Gln Leu Ile Asp Lys 
            180                 185                 190         


Asn Ser Gly Gln Phe Ile Leu Val Asp Pro Val Pro Gly Thr Leu Ala 
        195                 200                 205             


Val Asn Ile Gly Asp Ile Gly Lys Ala Trp Ser Asn Gly Arg Tyr Trp 
    210                 215                 220                 


Thr Ala Lys His Arg Val Arg Cys Phe Glu Pro Lys Thr Arg Tyr Ser 
225                 230                 235                 240 


Ile Ala Leu Phe Val Leu Gly Pro Asn Asp Lys Met Ile Glu Ala Pro 
                245                 250                 255     


Ser Gln Phe Val Asp Ser Glu His Pro Arg Tyr Tyr Val Pro Ile Asp 
            260                 265                 270         


Pro Lys Lys Tyr Arg Asp Val Arg Val Thr His Arg Ile Arg Thr Gly 
        275                 280                 285             


Val Ala Leu Glu Leu Phe Arg Thr Ser Val Thr 
    290                 295                 


<210>  324
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  324

Met Tyr Val Glu Met Glu Gln Thr Asn Asn His Asn Ile Glu Ala Lys 
1               5                   10                  15      


Ile Ile Asp Pro Ser Met Asn Thr Val Gln Gln Thr His Asn Tyr Phe 
            20                  25                  30          


Pro Lys Gln Phe Ile Trp Pro Lys Asp His Val Ser Arg Ala Ser Val 
        35                  40                  45              


Glu Val Leu Asn Glu His Val Ile Asp Leu Gln Gly Phe Phe Lys His 
    50                  55                  60                  


Asp Glu Lys Ala Thr Leu His Glu Ala Asn Leu Val Asn Glu Ser Cys 
65                  70                  75                  80  


Leu Lys His Gly Phe Phe Gln Val Ile Asn His Gly Ile Asp Pro Lys 
                85                  90                  95      


Leu Leu Ala Leu Ala Tyr Glu His Gly Trp Ala Phe Phe Gln Leu Pro 
            100                 105                 110         


Ile Thr Glu Lys Ser Lys Cys Lys Lys Lys Glu Gly Ser Met Asn Asp 
        115                 120                 125             


Phe Ser Asn Gly His Ala His Arg Phe Ala Glu Lys Leu Pro Trp Lys 
    130                 135                 140                 


Glu Cys Leu Thr Phe Glu Tyr His Glu Asn Asp Ser Asn Glu Val Ala 
145                 150                 155                 160 


Val Glu Phe Phe Asn Ser Thr Tyr Gly Ser Gln Tyr Lys Glu Thr Gly 
                165                 170                 175     


Leu Ile Tyr Gln Arg Phe Cys His Ala Met Arg Lys Leu Ser Leu Asp 
            180                 185                 190         


Ile Met Glu Leu Leu Glu Ile Ser Leu Gly Val Thr Ser Arg Lys Tyr 
        195                 200                 205             


Tyr Arg Gln Leu Phe Glu Asp Cys Val Ser Ile Val Arg Asn Asn Tyr 
    210                 215                 220                 


Tyr Pro Lys Cys Asp Tyr Pro Glu Leu Thr Tyr Gly Ala Gly Pro His 
225                 230                 235                 240 


Arg Asp Pro Thr Thr Leu Thr Val Leu Tyr Gln Asp Gln Phe Gly Gly 
                245                 250                 255     


Leu Glu Val Phe Val Asp Asn Lys Trp Lys Ala Val Gln Pro Arg Pro 
            260                 265                 270         


Asn Ala Leu Val Ile Asn Ile Gly Asp Thr Phe Thr Ala Leu Ser Asn 
        275                 280                 285             


Gly Lys Tyr Met Ser Cys Leu His Arg Val Thr Val Asn Thr Glu Thr 
    290                 295                 300                 


Gln Gly Leu Ala Leu Glu Phe Phe Leu Cys Pro Lys Ser Asp Lys Lys 
305                 310                 315                 320 


Met Lys Pro Pro Gln Glu Leu Ile Asp Lys Asp Gly Lys Gln Glu Tyr 
                325                 330                 335     


Pro Asp Phe Thr Trp Glu Glu Phe Leu Arg Phe Thr Gln Lys His His 
            340                 345                 350         


Arg Ala Asp Glu Asn Asn Leu Asp Ser Phe Asn Asn Trp Leu Lys Ser 
        355                 360                 365             


Ser Arg Ser Ser Asn Ala 
    370                 


<210>  325
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  325

Met Ser Met Asp Lys His Asn Glu Glu Ala Val Asn Phe Gly Arg Ser 
1               5                   10                  15      


Leu Ile Val Pro Ser Val Gln Glu Leu Ala Lys Gln Ser Ile Thr Lys 
            20                  25                  30          


Ile Pro Pro Arg Tyr Ala His Gln His Asp Asp Gln Val Gln Leu Asn 
        35                  40                  45              


Val Ser Cys Asp Gly Glu Leu Thr Ser Ser Val Pro Val Ile Asp Leu 
    50                  55                  60                  


Gln Cys Leu Phe Ala Asn Ala Asn Glu Ser Ser Val Tyr Ser Ser Glu 
65                  70                  75                  80  


Leu Asn Lys Leu His Thr Ala Ser Lys Glu Trp Gly Phe Phe Gln Val 
                85                  90                  95      


Ile Asn His Gly Ile Ser Glu Ser Leu Leu Asp Asp Phe Lys Lys Glu 
            100                 105                 110         


Val Leu Asn Phe Phe Asp Leu Pro Met Glu Glu Lys Gln Lys Leu Trp 
        115                 120                 125             


Gln Gln Glu Asp Asn His Glu Gly Phe Gly Gln Leu Phe Val Val Ser 
    130                 135                 140                 


Glu Glu Gln Lys Leu Asp Trp Ser Asp Met Phe Tyr Ile Thr Thr Leu 
145                 150                 155                 160 


Pro His Asp Leu Arg Lys Ser Gln Leu Phe Gln Lys Leu Pro Leu Asn 
                165                 170                 175     


Leu Arg Gln Lys Leu Glu Ala Tyr Ser Ala Glu Ile Lys Lys Leu Ala 
            180                 185                 190         


Met Ala Ile Leu Gly Gln Met Ala Lys Ala Leu Gly Met Asp Asp Thr 
        195                 200                 205             


Glu Ile Thr Glu Leu Phe Gln Asp Gly Val Gln Ser Met Arg Met Asn 
    210                 215                 220                 


Tyr Tyr Pro Pro Cys Pro Glu Pro Glu Met Ala Val Gly Phe Ser Pro 
225                 230                 235                 240 


His Ser Asp Ala Asp Ala Leu Thr Ile Leu Tyr Gln Leu Asn Thr Thr 
                245                 250                 255     


Glu Gly Leu Gln Ile Arg Lys Asp Gly Lys Trp Val Thr Ile Lys Pro 
            260                 265                 270         


Leu Pro Asn Ala Leu Val Val Asn Ile Gly Asp Ile Met Glu Ile Val 
        275                 280                 285             


Ser Asn Gly Val Tyr Lys Ser Ile Glu His Arg Ala Val Val Asn Ser 
    290                 295                 300                 


Asp Tyr Glu Arg Leu Ser Val Ala Thr Phe Tyr Ser Ser Thr Met Gly 
305                 310                 315                 320 


Thr Glu Leu Gly Pro Ala Gln Ser Leu Val Ala Gln His Thr Val Ala 
                325                 330                 335     


Asn Phe Arg Arg Val Pro Leu Glu Glu Tyr Phe Lys Gly Phe Phe Ala 
            340                 345                 350         


Arg Lys Leu Asp Gly Lys Ser Tyr Leu Asp Phe Met Lys Val Gly Glu 
        355                 360                 365             


Leu Lys Glu Asn Ile Thr Tyr 
    370                 375 


<210>  326
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  326

Met Ala Pro Ser Val Ser Val Ile His Ser Asn Pro Gln Ser Leu Leu 
1               5                   10                  15      


Asp Phe Val Val Asn Lys Gly His Gly Val Lys Gly Leu Ser Glu Leu 
            20                  25                  30          


Gly Leu Glu Thr Leu Pro His Gln Tyr Ile Gln Pro Pro Gln Glu Arg 
        35                  40                  45              


Leu Asp Ala Ser Asn Glu Glu Ser Asn Lys Asp Ser Ile Pro Val Ile 
    50                  55                  60                  


Asp Met Ser Asn Trp Asp Asp Pro Glu Val Ala Gln Ala Ile Cys Asp 
65                  70                  75                  80  


Ala Ala Arg Lys Trp Gly Phe Phe Gln Ile Val Asn His Arg Val Pro 
                85                  90                  95      


Ile His Val Leu Glu Asp Val Lys Asp Ala Thr Leu Lys Phe Phe Ala 
            100                 105                 110         


Leu Pro Ala Glu Glu Lys Leu Lys Tyr Ser Lys Glu Arg Ser Val Thr 
        115                 120                 125             


Asn Asn Ile Arg Phe Gly Thr Ser Phe Thr Pro Glu Thr Glu Lys Ala 
    130                 135                 140                 


Leu Glu Trp Lys Asp Tyr Leu Ser Leu Phe Phe Val Ser Val Asp Glu 
145                 150                 155                 160 


Ala Ala Ser Leu Trp Pro Pro Ile Cys Arg Asn Gln Ala Leu Glu Tyr 
                165                 170                 175     


Ile Glu Ala Ser Glu Leu Ile Val Lys Lys Leu Leu Lys Ile Leu Met 
            180                 185                 190         


Asn Gly Leu Asn Val Lys Glu Ile Asp Glu Ser Thr Glu Ser Ile Leu 
        195                 200                 205             


Met Gly Ser Lys Arg Ile Asn Leu Asn Tyr Tyr Pro Lys Cys Pro Asn 
    210                 215                 220                 


Pro Glu Leu Thr Val Gly Val Gly Arg His Ser Asp Val Ser Thr Leu 
225                 230                 235                 240 


Thr Val Leu Leu Gln Asp Asp Ile Gly Gly Leu Phe Val Arg Asn Thr 
                245                 250                 255     


Glu Thr Met Lys Trp Ile His Val Pro Pro Val Ser Gly Ser Leu Val 
            260                 265                 270         


Ile Asn Val Gly Asp Ala Leu Gln Ile Ile Ser Asn Gly His Tyr Lys 
        275                 280                 285             


Ser Val Glu His Arg Val Ser Ala Asn Gly Asn Ser Asn Arg Ile Ser 
    290                 295                 300                 


Val Pro Ile Phe Val Cys Pro Arg Pro Ser Asp Ile Ile Gly Pro Leu 
305                 310                 315                 320 


Pro Glu Val Val Gln Asn Gly Glu Lys Pro Ile Tyr Lys His Ile Leu 
                325                 330                 335     


Tyr Ser Asp Tyr Val Lys His Phe Phe Arg Lys Ala His Asp Gly Lys 
            340                 345                 350         


Ala Thr Ile Asp Phe Ala Lys Glu 
        355                 360 


<210>  327
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  327

Met Glu Lys Leu Asn Gly Glu Asp Arg Gln Ala Thr Met Asp Lys Ile 
1               5                   10                  15      


His Asp Ala Cys Glu Asn Trp Gly Phe Phe Glu Leu Val Asn His Gly 
            20                  25                  30          


Ile Ser Pro Glu Leu Leu Asp Arg Val Glu Arg Met Thr Lys Glu His 
        35                  40                  45              


Tyr Lys Asn Cys Met Glu Asp Arg Phe Lys Glu Met Val Ala Ala Lys 
    50                  55                  60                  


Ala Leu Glu Gly Val Thr Thr Glu Val Asn Asn Leu Asp Trp Glu Ser 
65                  70                  75                  80  


Thr Phe Phe Leu Arg His Leu Pro Thr Ser Asn Ile Ser Glu Ile Thr 
                85                  90                  95      


Asp Leu Glu Asp Glu Tyr Arg Asp Leu Met Lys Asp Phe Ala Gly Lys 
            100                 105                 110         


Leu Glu Lys Leu Ala Glu Glu Leu Leu Asp Leu Leu Cys Glu Asn Leu 
        115                 120                 125             


Gly Leu Glu Lys Gly Tyr Leu Lys Arg Ala Phe Tyr Gly Ser Lys Ser 
    130                 135                 140                 


Asn Gly Pro Asn Phe Gly Thr Lys Val Ser Asn Tyr Pro Pro Cys Pro 
145                 150                 155                 160 


Thr Pro Asp Leu Ile Lys Gly Leu Arg Ala His Thr Asp Ala Gly Gly 
                165                 170                 175     


Ile Ile Leu Leu Phe Gln Asp Asp Lys Val Ser Gly Leu Gln Leu Leu 
            180                 185                 190         


Lys Asp Gly Gln Trp Ile Asp Val Pro Pro Met Arg His Ser Ile Val 
        195                 200                 205             


Ile Asn Leu Gly Asp Gln Ile Glu Val Ile Thr Asn Gly Lys Tyr Lys 
    210                 215                 220                 


Ser Val Leu His Arg Val Ile Ala Gln Thr Asp Gly Thr Arg Met Ser 
225                 230                 235                 240 


Ile Ala Ser Phe Tyr Asn Pro Gly Asp Asp Ala Val Ile Tyr Pro Ala 
                245                 250                 255     


Lys Ile Leu Met Lys Glu Gln Thr Lys Asn Glu His Ser Tyr Pro Lys 
            260                 265                 270         


Phe Val Phe Asp Asp Tyr Met Lys Leu Tyr Ala Gly Leu Lys Phe Gln 
        275                 280                 285             


Ala Lys Glu Pro Arg Phe Glu Ala Met Lys Ala Ala Glu Ala Asn Val 
    290                 295                 300                 


Ile Ala Gly Pro Val Ala Thr Ala 
305                 310         


<210>  328
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  328

Met Ala Asp Lys Cys Thr Ile Pro Val Ile Asp Leu His Asn Leu Pro 
1               5                   10                  15      


Asn Gln Leu Pro Glu Leu Ile Ser Ala Cys Glu Asn Trp Gly Cys Phe 
            20                  25                  30          


Arg Leu Ile Asn His His Glu Ile Leu Ser Thr Lys Leu Met Leu Glu 
        35                  40                  45              


Met Lys Lys Val Val Arg Ser Leu Leu Asp Leu Pro Val Glu Ile Lys 
    50                  55                  60                  


Arg Arg Ser Ser Asp Ala Ile Ala Gly Ser Gly Tyr Met Ala Pro Ser 
65                  70                  75                  80  


Ala Lys Asn Pro Leu Tyr Glu Thr Leu Ala Leu Tyr Asp Met Ala Arg 
                85                  90                  95      


Ser Gly Asp Val Glu Arg Phe Cys Gln Glu Leu Asp Ala Thr His Asp 
            100                 105                 110         


Gln Arg Glu Ile Ile Met Arg Tyr Ala Glu Ala Val His Glu Leu Phe 
        115                 120                 125             


Met Arg Ile Ala Lys Lys Leu Ala Glu Gly Leu Gly Val Lys Arg Gly 
    130                 135                 140                 


Asp Ile Gly Phe Glu Asn Trp Pro Cys Glu Phe Arg Phe Asn Lys Tyr 
145                 150                 155                 160 


Asn Phe Ile Pro Glu Ser Val Gly Ser Pro Gly Val Gln Leu His Thr 
                165                 170                 175     


Asp Ser Ala Phe Leu Thr Ile Leu Gln Asp Asp Glu Ser Val Gly Gly 
            180                 185                 190         


Leu Glu Val Met Asp Lys Thr Gly Lys Phe Ile Thr Ile Asn Pro Trp 
        195                 200                 205             


Pro Asp Thr Leu Leu Val Asn Leu Gly Asp Met Ala Thr Val Trp Ser 
    210                 215                 220                 


Asn Gly Arg Phe Cys Asn Val Lys His Arg Val Gln Cys Lys Glu Ala 
225                 230                 235                 240 


Lys Ile Arg Val Ser Ile Ala Ser Phe Phe Leu Gly Pro Arg Gly Val 
                245                 250                 255     


Val Lys Pro Leu Ser Glu Leu Val Asp Asp Asp His Pro Leu Val Tyr 
            260                 265                 270         


Met Pro Thr Thr Tyr Glu Asp Tyr Arg Lys Met Arg Leu Ser Thr Asn 
        275                 280                 285             


Leu Lys Ala Gly Glu Ala Leu Glu His Leu Tyr Thr Ser Ser Phe Lys 
    290                 295                 300                 


Lys 
305 


<210>  329
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  329

Met Ala Pro Ser Ile Ser Ile Thr Asn Thr Lys Ser Leu Asn Ile Met 
1               5                   10                  15      


Asp Phe Val Val Asn Lys Gly His Gly Val Lys Gly Leu Ala Glu Leu 
            20                  25                  30          


Gly Leu Lys Thr Leu Pro His Gln Tyr Ile Gln Pro Pro Gln Glu Arg 
        35                  40                  45              


Phe Asp Ser Ser Asn Glu Glu Pro Asn Gln Asp Ser Ile Pro Val Ile 
    50                  55                  60                  


Asp Met Ser Asn Trp Asp Asp Leu Asn Val Ala Lys Ala Ile Cys Asp 
65                  70                  75                  80  


Ala Ala Ser Lys Trp Gly Phe Phe Gln Ile Val Asn His Gly Val Pro 
                85                  90                  95      


Ile His Val Leu Asp Asp Val Lys Asp Ala Thr Arg Lys Phe Phe Ala 
            100                 105                 110         


Leu Pro Ala Glu Glu Lys Leu Lys Phe Ser Lys Glu Lys Ser Val Thr 
        115                 120                 125             


Asn Ser Ile Arg Phe Gly Thr Ser Phe Thr Pro Glu Ala Glu Lys Ala 
    130                 135                 140                 


Leu Glu Trp Lys Asp Tyr Leu Ser Leu Phe Phe Val Ser Asp Asp Glu 
145                 150                 155                 160 


Ala Glu Thr Leu Trp Pro Ser Val Cys Arg Asn Gln Ala Leu Glu Tyr 
                165                 170                 175     


Ile Lys Ser Ser Glu Leu Val Val Lys Lys Leu Leu Lys Ile Leu Met 
            180                 185                 190         


Asn Gly Leu Asn Val Lys Glu Val Asp Glu Ala Lys Glu Ser Lys Leu 
        195                 200                 205             


Met Gly Ser Lys Arg Ile Asn Leu Asn Tyr Tyr Pro Lys Cys Pro Asn 
    210                 215                 220                 


Pro Glu Leu Thr Val Gly Val Gly Arg His Ser Asp Val Ser Thr Leu 
225                 230                 235                 240 


Thr Ile Leu Leu Gln Asp Glu Ile Gly Gly Leu Tyr Val Arg Asn Met 
                245                 250                 255     


Ala Thr Met Lys Trp Ile His Val Pro Pro Val Ser Gly Ser Leu Val 
            260                 265                 270         


Ile Asn Val Gly Asp Ala Leu Gln Ile Ile Ser Asn Gly Lys Tyr Lys 
        275                 280                 285             


Ser Val Glu His Arg Val Ser Ala Asn Gly Ser Ser Asn Arg Ile Ser 
    290                 295                 300                 


Val Pro Ile Phe Val Asn Pro Arg Pro Ser Asp Val Ile Gly Pro Leu 
305                 310                 315                 320 


Gln Glu Leu Val Asp Ser Gly Glu Lys Pro Leu Tyr Lys Asn Val Val 
                325                 330                 335     


Tyr Ser Asp Tyr Val Lys His Phe Phe Arg Lys Ala His Asp Gly Lys 
            340                 345                 350         


Ala Thr Ile Asp Phe Ala Lys Val 
        355                 360 


<210>  330
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  330

Met Ala Pro Phe Leu Thr Asp Met His Glu Leu Lys Thr Phe Val Val 
1               5                   10                  15      


Asn Glu Gly Asn Gly Val Lys Gly Leu Ser Glu Leu Lys Ile Lys Thr 
            20                  25                  30          


Val Pro Glu Leu Phe Ile Gln Pro Leu Glu Lys Arg Leu Asp Met Ser 
        35                  40                  45              


Lys Val Val Leu Lys Glu Ser Ile Pro Val Ile Asp Met Ser Asn Tyr 
    50                  55                  60                  


Glu Asp Pro Glu Val Met Asp Ser Ile Cys Asp Ala Ala Glu Lys Trp 
65                  70                  75                  80  


Gly Phe Phe Gln Val Val Asn His Asp Val Pro Leu Ser Val Leu Glu 
                85                  90                  95      


Asp Val Lys Lys Ala Thr Arg Arg Phe Phe Glu Leu Pro Ala Asp Glu 
            100                 105                 110         


Lys Lys Lys Tyr Leu Phe Asn Asn Ser Pro Ser Lys Asn Val Arg Leu 
        115                 120                 125             


Leu Ser Ser Phe Val Pro Glu Val Asp Lys Ala Met Glu Trp Lys Asp 
    130                 135                 140                 


Tyr Leu Ser Cys Phe Tyr Val Ser Asp Asp Glu Ala Met Ala Phe Trp 
145                 150                 155                 160 


Pro Ser Val Cys Arg Asp Gln Val Leu Glu Tyr Met Ser Lys Ser Glu 
                165                 170                 175     


Ser Leu Ile Lys Arg Leu Leu Glu Ile Leu Ile Lys Arg Leu Gly Ile 
            180                 185                 190         


Thr Lys Leu Asp Glu Thr Asn Gln Pro Leu Leu Met Gly Ser Arg Arg 
        195                 200                 205             


Val Asn Leu Asn Tyr Tyr Pro Ile Cys Pro Asn Pro Glu Leu Thr Val 
    210                 215                 220                 


Gly Val Gly Gly His Ser Asp Val Ser Thr Leu Thr Val Leu Leu Gln 
225                 230                 235                 240 


Asp Glu Thr Gly Gly Leu Tyr Val Arg Lys Leu Asp Ser Asp Asn Trp 
                245                 250                 255     


Ile His Val Pro Pro Val Lys Gly Ser Leu Thr Ile Asn Ile Gly Asp 
            260                 265                 270         


Ala Leu Gln Ile Met Ser Asn Gly Arg Tyr Lys Ser Ile Glu His His 
        275                 280                 285             


Val Val Ala Asn Met His Glu Asn Arg Val Ser Val Pro Ile Phe Val 
    290                 295                 300                 


Asn Pro Arg Pro Asn Asp Val Ile Gly Pro Leu Pro Glu Val Ile Lys 
305                 310                 315                 320 


Gly Gly Glu Lys Ala Leu Tyr Lys Gln Val Leu Tyr Ser Asp Tyr Val 
                325                 330                 335     


Lys His Phe Tyr Lys Lys Ser His Asn Gly Lys Asp Thr Ile Asp Phe 
            340                 345                 350         


Ala Lys Leu Ser Leu Ile Asp Phe Thr Ser Gly Ser Trp Ala Ala Cys 
        355                 360                 365             


His Leu Val Asn Arg Ser Pro Ser Thr Ala Ile Asp Ile Lys Thr Pro 
    370                 375                 380                 


Gln Glu Val Leu Ser Glu Lys Pro Ser Asn Tyr Ser Asp Leu Arg Ile 
385                 390                 395                 400 


Phe Trp Cys Pro Ala Tyr Ala His Val Asn Asp Ser Lys Val Glu Ser 
                405                 410                 415     


Arg Gly Tyr Gly Val His Ile Tyr Arg Val Trp Glu Trp Lys Arg Arg 
            420                 425                 430         


Asp Arg Trp Cys His Arg Glu Gly Ser Gly Cys Ser Cys Leu Lys Val 
        435                 440                 445             


Glu Phe Ala Thr Ser Thr Pro Asn Arg Val Met Ile Asp Asp Lys Gln 
    450                 455                 460                 


Gln Pro Pro Lys Glu Pro Thr Ser Lys Ala Leu Glu Thr Ser Gly Leu 
465                 470                 475                 480 


Phe Thr Gly Leu Glu Pro Glu Glu Thr Glu Pro His Asp Thr Glu His 
                485                 490                 495     


Met Thr Glu Glu Glu Gly Asp Ser Glu Pro Ile Ala Leu Thr Lys Lys 
            500                 505                 510         


Lys Arg Met Arg Ser His Arg Leu Tyr Ile Gln Val Ser Val Val Lys 
        515                 520                 525             


Leu Met His Cys Lys Trp Val Phe Lys Lys Lys Glu Gly Ile Pro Gly 
    530                 535                 540                 


Val Gly Pro Glu Arg Phe Lys Ala Arg Leu Val Ala Lys Gly Phe Phe 
545                 550                 555                 560 


Thr Lys Leu Glu Cys Phe Lys Leu Ala Thr Asn Leu Val Tyr His Glu 
                565                 570                 575     


Arg Thr Lys His Ile Asp Met Arg Leu Asn Ile Ile Arg Asp Val Leu 
            580                 585                 590         


Lys Glu Asp Ile Phe Cys Ile Gln Lys Ile Ala Thr Glu Glu Asn Pro 
        595                 600                 605             


Ser Asp Ile Leu Thr Lys Pro Leu Pro Pro Lys Ser Ser Ser Phe Ala 
    610                 615                 620                 


Trp Thr Trp Leu Lys Asn Pro Val Asn Ile Leu Leu Gln Lys Pro Phe 
625                 630                 635                 640 


Lys Tyr Lys Gly Tyr Gly 
                645     


<210>  331
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  331

Met Ala Pro Ser Val Ser Val Ile His Ser Asn Pro Leu Ser Leu Leu 
1               5                   10                  15      


Asp Phe Val Val Asn Lys Gly His Gly Val Lys Gly Leu Ser Glu Leu 
            20                  25                  30          


Gly Leu Glu Thr Leu Pro His Gln Tyr Ile Gln Pro Pro Gln Glu Arg 
        35                  40                  45              


Leu Asp Ala Ser Asn Glu Glu Ser Asn Lys Asp Ser Ile Pro Val Ile 
    50                  55                  60                  


Asp Met Ser Asn Trp Asp Asp Pro Glu Val Ala Gln Ala Ile Cys Asp 
65                  70                  75                  80  


Ala Ala Arg Lys Trp Gly Phe Phe Gln Ile Val Asn His Arg Val Pro 
                85                  90                  95      


Ile His Val Leu Glu Asp Val Lys Asp Ala Thr Leu Lys Phe Phe Ala 
            100                 105                 110         


Leu Pro Ala Glu Glu Lys Leu Lys Tyr Ser Lys Glu Arg Ser Val Thr 
        115                 120                 125             


Asn Asn Ile Arg Phe Gly Thr Ser Phe Thr Pro Glu Thr Glu Lys Ala 
    130                 135                 140                 


Leu Glu Trp Lys Asp Tyr Leu Ser Leu Phe Phe Val Ser Val Asp Glu 
145                 150                 155                 160 


Ala Ala Ser Leu Trp Pro Pro Ile Cys Arg Asn Gln Ala Leu Asp Tyr 
                165                 170                 175     


Ile Glu Ala Ser Glu Leu Ile Val Lys Lys Leu Leu Lys Ile Leu Met 
            180                 185                 190         


Asn Gly Leu Asn Val Lys Glu Ile Asp Glu Ser Thr Glu Ser Ile Leu 
        195                 200                 205             


Met Gly Ser Lys Arg Ile Asn Leu Asn Tyr Tyr Pro Lys Cys Pro Asn 
    210                 215                 220                 


Pro Glu Leu Thr Val Gly Val Gly Arg His Ser Asp Val Ser Thr Leu 
225                 230                 235                 240 


Thr Val Leu Leu Gln Asp Asp Ile Gly Gly Leu Phe Val Arg Asn Thr 
                245                 250                 255     


Glu Thr Met Lys Trp Ile His Val Pro Pro Val Ser Gly Ser Leu Val 
            260                 265                 270         


Ile Asn Val Gly Asp Ala Leu Gln Ile Ile Ser Asn Gly His Tyr Lys 
        275                 280                 285             


Ser Val Glu His Arg Val Ser Ala Asn Gly Asn Gly Asn Arg Ile Ser 
    290                 295                 300                 


Val Pro Ile Phe Val Cys Pro Arg Pro Ser Asp Ile Ile Gly Pro Leu 
305                 310                 315                 320 


Pro Glu Val Val Gln Asn Gly Glu Lys Pro Leu Tyr Lys His Ile Leu 
                325                 330                 335     


Tyr Ser Asp Tyr Val Lys His Phe Phe Arg Lys Ala His Asp Gly Lys 
            340                 345                 350         


Ala Thr Ile Asp Phe Ala Lys Gly Asp Ser 
        355                 360         


<210>  332
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  332

Met Gly Ser Leu Ile Leu Pro Lys Leu Leu Val Val Asp Phe Thr Asn 
1               5                   10                  15      


Asp Asn Leu Lys Pro Gly Thr Ser Val Trp Ser Ser Thr Cys Asn Asp 
            20                  25                  30          


Ile Arg Val Ala Leu Glu Asn His Gly Cys Phe Ile Ala Leu Tyr Asp 
        35                  40                  45              


Gly Val Ser Ser Lys Leu Gln Asp Ser Val Phe Arg Ala Ala Glu Glu 
    50                  55                  60                  


Leu Phe Asp Leu Pro Thr Glu Thr Lys Ile Lys Asn Ile Val Glu Lys 
65                  70                  75                  80  


Pro Tyr His Gly Tyr Val Gly Gln Met Pro Ile Val Pro Leu His Glu 
                85                  90                  95      


Gly Leu Gly Ile Asp Tyr Ala Thr Asp Leu Glu Gly Ala Gln Ser Phe 
            100                 105                 110         


Thr Asp Ile Met Trp Pro Asp Gly Asn Gln Ser Phe Cys Glu Thr Ser 
        115                 120                 125             


Met Ser Phe Ser Arg Ala Val Ala Lys Leu Asp Gln Thr Val Val Arg 
    130                 135                 140                 


Met Leu Phe Glu Ser Tyr Gly Val Glu Lys Gln Ser Ala Ser His Ile 
145                 150                 155                 160 


Glu Ser Thr Thr Tyr Leu Leu Arg Tyr Leu Lys Tyr Arg Ala Pro Glu 
                165                 170                 175     


Thr Asn Glu Thr Thr Met Ala Phe Pro Ser His Thr Asp Lys Ser Phe 
            180                 185                 190         


Leu Thr Ile Leu His Gln Asn Gln Val Ser Gly Leu Glu Ile Arg Ser 
        195                 200                 205             


Arg Asp Glu Glu Trp Ile Ser Val Gln Phe Pro Ala Ser Ser Phe Val 
    210                 215                 220                 


Val Met Ala Gly Asp Ala Cys Lys Ala Trp Ser Asn Asn Arg Val Leu 
225                 230                 235                 240 


Ser Pro Asn His Lys Val Thr Met Asp Lys Gln Glu Lys Glu Thr Arg 
                245                 250                 255     


Tyr Thr Ile Ala Leu Phe Ser Phe Leu Ser Lys Lys Val Gln Ile Pro 
            260                 265                 270         


Asp Glu Phe Val Asp Ala Asp His Pro Leu Gln Phe Lys Pro Phe Asp 
        275                 280                 285             


His Ile Asp Leu Leu Asn Phe Tyr Val Thr Glu Asn Gly Arg Lys Ser 
    290                 295                 300                 


Gln Asn Ile Leu Lys Asp Phe Cys Gly Val 
305                 310                 


<210>  333
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  333

Met Glu Gln Thr Asn Asn Leu Glu Ala Lys Ile Ile Asp Gln Ser Met 
1               5                   10                  15      


Asn Thr Ile Gln Gln Thr His Asn His Phe Pro Lys Gln Phe Ile Trp 
            20                  25                  30          


Pro Lys Asp His Val Ser Arg Ala Ser Val Glu Val Leu Asn Glu His 
        35                  40                  45              


Val Ile Asp Leu Gln Gly Phe Phe Lys His Asp Glu Lys Ala Thr Leu 
    50                  55                  60                  


His Glu Ala Asn Leu Val Asn Glu Ser Cys Leu Lys His Gly Phe Phe 
65                  70                  75                  80  


Gln Val Ile Asn His Gly Ile Asp Pro Lys Leu Leu Ala Leu Ala Tyr 
                85                  90                  95      


Glu His Gly Trp Ala Phe Phe Gln Leu Pro Val Thr Glu Lys Ser Lys 
            100                 105                 110         


Cys Lys Lys Lys Glu Gly Ser Met Asn Asp Phe Ser Asn Gly His Ala 
        115                 120                 125             


His Arg Phe Thr Glu Lys Leu Pro Trp Lys Glu Cys Leu Thr Phe Glu 
    130                 135                 140                 


Tyr His Glu Asn Asp Ser Asp Glu Val Ala Ser Glu Phe Phe Asn Ser 
145                 150                 155                 160 


Thr Tyr Gly Ser Gln Tyr Lys Glu Thr Gly Leu Ser Tyr Gln Lys Phe 
                165                 170                 175     


Cys His Asp Met Arg Lys Leu Ser Leu Asp Ile Met Glu Leu Leu Glu 
            180                 185                 190         


Ile Ser Leu Gly Val Thr Ser Arg Asn Tyr Tyr Arg Gln Leu Phe Glu 
        195                 200                 205             


Asp Cys Val Ser Ile Val Arg Ser Asn Tyr Tyr Pro Asn Cys Asp Asn 
    210                 215                 220                 


Pro Glu Leu Thr Tyr Gly Val Gly Pro His Cys Asp Pro Thr Thr Leu 
225                 230                 235                 240 


Thr Val Leu Tyr Gln Asp Gln Leu Gly Gly Leu Glu Val Phe Val Asp 
                245                 250                 255     


Asn Lys Trp Lys Ala Val Gln Pro Arg Pro Asn Ala Leu Val Ile Asn 
            260                 265                 270         


Ile Gly Asp Thr Phe Lys Ala Leu Ser Asn Gly Lys Tyr Met Ser Cys 
        275                 280                 285             


Leu His Arg Val Thr Val Asn Thr Lys Thr Pro Arg Leu Thr Leu Ala 
    290                 295                 300                 


Phe Phe Leu Cys Pro Lys Ser Asp Lys Lys Met Lys Pro Pro Gln Glu 
305                 310                 315                 320 


Leu Ile Asp Lys Asp Gly Lys Gln Glu Tyr Pro Asp Phe Thr Trp Glu 
                325                 330                 335     


Glu Phe Leu Arg Phe Thr Gln Lys His His Arg Ala Asp Glu Asn Thr 
            340                 345                 350         


Leu Asp Leu Phe Asn Asn Trp Leu Lys Ser Ser Lys Ser Ser Asn Ala 
        355                 360                 365             


<210>  334
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  334

Met Ala Pro Ser Thr Pro Ile Ile Asn Ser Asn Ser Leu Asn Ile Leu 
1               5                   10                  15      


Asp Phe Val Val Asn Lys Gly His Gly Val Lys Gly Leu Ser Glu Leu 
            20                  25                  30          


Gly Leu Lys Thr Leu Pro His Gln Tyr Ile Gln Pro Pro Gln Glu Arg 
        35                  40                  45              


Phe Asp Ser Ser Asn Glu Glu Pro Asn Lys Asp Ser Ile Pro Val Ile 
    50                  55                  60                  


Asp Met Ser Asn Pro Asn Asp Pro His Val Ala Lys Ala Ile Cys Asp 
65                  70                  75                  80  


Ala Ala Gln Lys Trp Gly Phe Phe Gln Ile Val Asn His Gly Val Pro 
                85                  90                  95      


Ile His Val Leu Glu Asp Val Lys Asn Ala Thr His Lys Phe Phe Ala 
            100                 105                 110         


Leu Ala Pro Gln Glu Lys Gln Lys Tyr Ser Lys Ser Gln Ser Val Thr 
        115                 120                 125             


Asn Asn Val Arg Phe Gly Thr Ser Phe Thr Pro Glu Ala Glu Lys Ala 
    130                 135                 140                 


Leu Glu Trp Lys Asp Tyr Leu Ser Leu Phe Phe Val Ser Asn Asp Glu 
145                 150                 155                 160 


Ala Ala Ser Leu Trp Pro Pro Ile Cys Gly Lys Gln Ala Leu Glu Tyr 
                165                 170                 175     


Met Lys Ser Ser Glu Ser Val Val Lys Lys Leu Leu Glu Ile Leu Met 
            180                 185                 190         


His Gly Leu Asn Val Lys Glu Ile Asp Glu Thr Lys Gln Ser Ile Leu 
        195                 200                 205             


Met Gly Ser Lys Arg Ile Asn Leu Asn Tyr Tyr Pro Lys Cys Pro Asn 
    210                 215                 220                 


Pro Glu Leu Thr Val Gly Val Gly Arg His Ser Asp Val Ser Thr Leu 
225                 230                 235                 240 


Thr Ile Leu Leu Gln Asp Asp Ile Gly Gly Leu Tyr Val Arg Asn Thr 
                245                 250                 255     


Glu Thr Met Lys Trp Ile His Val Pro Pro Val Ser Gly Ser Leu Val 
            260                 265                 270         


Ile Asn Val Gly Asp Ala Leu Gln Ile Met Ser Asn Gly Lys Tyr Lys 
        275                 280                 285             


Ser Val Glu His Arg Val Ser Ala Asn Gly Ser Asn Asn Arg Ile Ser 
    290                 295                 300                 


Val Pro Ile Phe Val Asn Pro Arg Pro Ser Asp Ile Ile Gly Pro Met 
305                 310                 315                 320 


Ala Glu Val Leu Gln Ser Gly Glu Thr Pro Leu Tyr Lys His Val Val 
                325                 330                 335     


Tyr Ser Asp Tyr Val Lys His Phe Phe Arg Lys Ala His Asp Gly Lys 
            340                 345                 350         


Ala Thr Val Glu Phe Ala Lys Tyr Thr Trp Lys Gln Ala Leu Glu Tyr 
        355                 360                 365             


Met Lys Ser Ser Glu Ser Val Val Lys Lys Leu Leu Glu Ile Leu Met 
    370                 375                 380                 


His Gly Leu Asn Val Lys Glu Ile Asp Glu Thr Lys Gln Ser Ile Leu 
385                 390                 395                 400 


Met Gly Ser Lys Arg Ile Asn Leu Asn Tyr Tyr Pro Lys Cys Pro Asn 
                405                 410                 415     


Pro Glu Leu Thr Val Gly Val Gly Arg His Ser Asp Val Pro Thr Leu 
            420                 425                 430         


Thr Ile Leu Leu Gln Asp Asp Ile Gly Gly Leu Tyr Val Arg Asn Thr 
        435                 440                 445             


Glu Thr Met Lys Trp Ile His Val Pro Pro Val Ser Gly Ser Leu Val 
    450                 455                 460                 


Ile Asn Val Gly Asp Ala Leu Gln Ile Met Ser Asn Asp Lys Tyr Lys 
465                 470                 475                 480 


Ser Val Glu His Arg Val Ser Ala Asn Gly Ser Asn Asn Arg Ile Ser 
                485                 490                 495     


Val Pro Ile Phe Val Asn Pro Arg Pro Ser Asp Val Ile Gly Pro Ile 
            500                 505                 510         


Ala Glu Val Leu Gln Ser Gly Glu Thr Pro Leu Tyr Lys His Val Val 
        515                 520                 525             


Tyr Ser Asp Tyr Val Lys His Phe Phe Arg Lys Ala His Asp Gly Lys 
    530                 535                 540                 


Val 
545 


<210>  335
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  335

Met Ser Thr Glu Asn Asn Lys Glu Glu Ala Ile Asn Leu Gly Arg Ser 
1               5                   10                  15      


Leu Ile Val Pro Ser Val Gln Glu Leu Ala Lys Arg Ser Ile Thr His 
            20                  25                  30          


Ile Pro Pro Glu Tyr Ala His Gln Leu Asp Gln Asp Gln Leu Leu Leu 
        35                  40                  45              


Ser Cys Asp Asp Val Leu Thr Pro Ser Val Pro Val Ile Asp Leu Gln 
    50                  55                  60                  


Ser Leu Phe Ala Asn Thr Ile Glu Ser Ser Val Glu Tyr Leu Phe Glu 
65                  70                  75                  80  


Leu Asn Lys Leu His Thr Ala Ser Lys Glu Trp Gly Phe Phe Gln Val 
                85                  90                  95      


Ile Asn His Gly Ile Ser Glu Ser Leu Leu Ala Asp Phe Lys Arg Asp 
            100                 105                 110         


Val Leu Asn Phe Phe Asn Leu Pro Met Glu Glu Lys Lys Lys Leu Trp 
        115                 120                 125             


Gln Glu Glu Asp Lys Met Lys Val Ser Val Ser Cys Leu Leu Gln Thr 
    130                 135                 140                 


Leu Glu Ala Tyr Cys Val Glu Ile Lys Lys Leu Ala Thr Val Ile Leu 
145                 150                 155                 160 


Gly Gln Met Gly Lys Ala Leu Glu Met Asp Glu Asp Gln Ile Asn Glu 
                165                 170                 175     


Leu Phe His Asp Gly Phe Gln Ser Met Arg Met Asn His Tyr Pro Pro 
            180                 185                 190         


Arg Pro Gln Pro Asn Met Ala Met Gly Leu Ser Pro His Ser Asp Ala 
        195                 200                 205             


Gly Ala Leu Thr Ile Val Asn Gln Leu Asn Thr Thr Asp Gly Leu Glu 
    210                 215                 220                 


Ile Arg Lys Asp Gly Lys Trp Val Thr Ile Lys Pro Leu Pro Asn Ala 
225                 230                 235                 240 


Leu Leu Val Asn Ile Gly Asp Ile Met Glu Ile Val Ser Asn Gly Val 
                245                 250                 255     


Tyr Lys Ser Ile Glu His Arg Ala Ile Val Asn Ala His Ser Glu Arg 
            260                 265                 270         


Leu Ser Val Ala Thr Phe Tyr Cys Ser Asn Ile Ala Thr Leu Leu Gly 
        275                 280                 285             


Pro Ala Lys Ser Leu Val Ala Lys His Lys Val Ala Asn Phe Lys Gln 
    290                 295                 300                 


Ile Pro Leu Glu Glu Tyr Phe Lys Gly Phe Phe Ala Arg Lys Leu Asp 
305                 310                 315                 320 


Gly Lys Ser Tyr Leu Glu Ile Met Lys Leu Glu Ser 
                325                 330         


<210>  336
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  336

Met Ser Val Asp Lys His Asn Glu Glu Ala Val Asn Phe Gly Arg Ser 
1               5                   10                  15      


Leu Ile Val Pro Ser Val Gln Glu Leu Ala Lys Gln Ser Ile Thr Gln 
            20                  25                  30          


Ile Pro Pro Arg Tyr Ala His Gln His Asp Asp Gln Val Gln Leu Asn 
        35                  40                  45              


Val Ser Cys Asp Asp His Ala Val Asn Ser Ser Val Pro Val Ile Asp 
    50                  55                  60                  


Leu Gln Cys Leu Phe Ala Asn Ala Asn Glu Ser Ser Val Tyr Ser Ser 
65                  70                  75                  80  


Glu Leu Asn Lys Leu His Thr Ala Ser Lys Glu Trp Gly Phe Phe Gln 
                85                  90                  95      


Val Ile Asn His Gly Ile Ser Glu Ser Leu Leu Asp Asp Phe Lys Lys 
            100                 105                 110         


Glu Val Leu Asn Phe Phe Asn Leu Pro Met Glu Glu Lys Gln Lys Leu 
        115                 120                 125             


Trp Gln Gln Glu Asp Asn His Glu Gly Phe Gly Gln Leu Phe Val Val 
    130                 135                 140                 


Ser Glu Glu Gln Lys Leu Asp Trp Ser Asp Met Phe Tyr Ile Thr Thr 
145                 150                 155                 160 


Leu Pro His Asp Leu Arg Lys Ser Gln Leu Phe Gln Lys Leu Pro Leu 
                165                 170                 175     


Asn Leu Arg Gln Lys Leu Glu Ala Tyr Ser Gly Glu Ile Lys Lys Leu 
            180                 185                 190         


Ala Met Ala Ile Leu Gly Gln Met Ala Lys Ala Leu Gly Met Asp Asp 
        195                 200                 205             


Met Glu Ile Thr Glu Leu Phe Gln Asp Gly Val Gln Ser Met Arg Met 
    210                 215                 220                 


Asn Tyr Tyr Pro Pro Cys Pro Glu Pro Glu Met Ala Val Gly Phe Ser 
225                 230                 235                 240 


Pro His Ser Asp Ala Asp Ala Leu Thr Ile Leu Tyr Gln Leu Asn Thr 
                245                 250                 255     


Thr Glu Gly Leu Gln Ile Arg Lys Asp Gly Arg Trp Val Thr Ile Lys 
            260                 265                 270         


Pro Leu Pro Asn Ala Leu Val Val Asn Ile Gly Asp Leu Met Glu Ile 
        275                 280                 285             


Val Ser Asn Gly Val Tyr Lys Ser Ile Glu His Arg Ala Val Val Asn 
    290                 295                 300                 


Ser Asp Tyr Glu Arg Leu Ser Val Ala Thr Phe Tyr Ser Ser Thr Met 
305                 310                 315                 320 


Gly Thr Glu Leu Gly Pro Ala Gln Ser Leu Val Ala Gln His Lys Val 
                325                 330                 335     


Ala Lys Phe Arg Arg Val Pro Leu Glu Glu Tyr Phe Lys Gly Phe Phe 
            340                 345                 350         


Ala Arg Lys Leu Asp Gly Lys Ser Tyr Leu Asp Phe Met Lys Val Glu 
        355                 360                 365             


Glu Leu Lys Glu Asn Ile Ala Tyr 
    370                 375     


<210>  337
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  337

Met Glu Pro Lys Asp Ile Ser Ser Ala Val Ser Leu Val Val Pro Ser 
1               5                   10                  15      


Val Gln Glu Leu Val Lys Glu Pro Leu Thr Arg Ile Pro Pro Arg Tyr 
            20                  25                  30          


Ile Arg Leu Asp Gln Asp Pro Pro Val Ile Ser Ser Ser Leu Ser Ser 
        35                  40                  45              


Asn Pro Glu Leu Pro Ile Ile Asp Met Lys Arg Leu Leu Ser Leu Asp 
    50                  55                  60                  


Ser Val Asp Ser Glu Leu Glu Lys Leu His Leu Ala Cys Arg Asp Trp 
65                  70                  75                  80  


Gly Phe Phe Gln Leu Ile Asn His Glu Val Ser Ser Ser Leu Ile Glu 
                85                  90                  95      


Lys Val Lys Glu Glu Thr Gln Glu Phe Phe Lys Leu Pro Leu Asp Glu 
            100                 105                 110         


Lys Lys Lys Tyr Ala Gln Lys Pro Gly Asp Phe Gln Gly Phe Gly Gln 
        115                 120                 125             


Leu Phe Val Val Ser Glu Glu Gln Lys Leu Asp Trp Ala Asp Val Phe 
    130                 135                 140                 


Ser Met Ile Thr Leu Pro Ser His Leu Arg Lys Pro His Leu Leu Pro 
145                 150                 155                 160 


Lys Leu Pro Gln Pro Phe Arg Asp Thr Ile Asp Glu Tyr Ser Lys Glu 
                165                 170                 175     


Ile Glu Lys Val Ala Leu Arg Thr Leu Met Phe Ile Ser Lys Ala Leu 
            180                 185                 190         


Lys Met Glu Val Glu Glu Ile Lys Ser Leu Phe Asp Asp Gly Leu Gln 
        195                 200                 205             


Ile Ile Arg Ile Asn Tyr Tyr Pro Pro Cys Pro Gln Pro Glu Gln Val 
    210                 215                 220                 


Ile Gly Leu Thr Pro His Ser Asp Gly Pro Gly Ile Thr Leu Leu Leu 
225                 230                 235                 240 


Gln Val Asn Gln Val Asp Gly Leu Glu Ile Lys Lys Asp Gly Asn Trp 
                245                 250                 255     


Ile Pro Val Met Pro His Pro Asn Ala Phe Ile Val Asn Ile Gly Asp 
            260                 265                 270         


Ile Met Glu Met Val Thr Asn Gly Glu Tyr Arg Ser Ile Gln His Arg 
        275                 280                 285             


Ala Val Val Asn Ala Asn Lys Glu Arg Leu Ser Ile Ala Thr Phe Val 
    290                 295                 300                 


Ser Pro Lys Val Asp Ala Asn Ile Gly Pro Ala Thr Ser Leu Ile Thr 
305                 310                 315                 320 


Pro Glu Lys Pro Pro Arg Phe Arg Ser Val Pro Leu Ser Asp Tyr Leu 
                325                 330                 335     


Lys Asn Arg Leu Ser Lys Lys Leu Asp Val Lys Gly Asn Ile Glu Gln 
            340                 345                 350         


Tyr Tyr Ile 
        355 


<210>  338
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  338

Met Val Thr Met Gly Ala Pro Val Ile Asp Met Gln Asn Val Asp Gly 
1               5                   10                  15      


Leu Ala Glu Glu Leu Val Lys Ala Cys Val Glu Phe Gly Cys Phe Arg 
            20                  25                  30          


Val Val Asn His Gly Val Pro Met Glu Leu Met Ala Glu Met Lys Val 
        35                  40                  45              


Val Val Ala Glu Leu Phe Asn Leu Pro Glu Glu Ile Lys Arg Gln Thr 
    50                  55                  60                  


Ala Thr Asn Asn Pro Glu His Gly Lys Gly Tyr Ile Gly Cys Asn Pro 
65                  70                  75                  80  


Ile Thr Pro Phe Leu Glu Gly Phe Ser Ile Asp Glu Ile Arg Ser Pro 
                85                  90                  95      


Asn Glu Phe Cys Asp Cys Leu Gly Ala Ser Leu His Gln Arg Glu Ile 
            100                 105                 110         


Ile Ser Lys Tyr Ile Lys Ser Ile Cys Asp Leu Asn Lys Phe Leu Gly 
        115                 120                 125             


Gln Lys Leu Met Glu Gly Cys Gly Leu Thr Gly Asp Leu Phe Asp Gly 
    130                 135                 140                 


Trp Cys Cys Gln Leu Arg Leu Asn Lys Tyr His Phe Cys Pro Glu Ser 
145                 150                 155                 160 


Ile Gly Leu Asn Gly Thr Pro Thr His Thr Asp Pro Ser Phe Leu Thr 
                165                 170                 175     


Ile Leu Gln Asp Asp Glu Asp Val Asn Gly Leu Gln Val Val Asp Lys 
            180                 185                 190         


Val Ser Gly Glu Phe Val Pro Phe Asp His Val Pro Gly Thr Leu Ala 
        195                 200                 205             


Ile Asn Ile Gly Asp Ile Gly Lys Ala Trp Ser Asn Gly Arg Phe Cys 
    210                 215                 220                 


Ser Val Lys His Arg Val Leu Cys Phe Glu Pro Lys Thr Arg Tyr Ser 
225                 230                 235                 240 


Ile Ala Leu Phe Val Met Gly Pro Asn Asp Lys Ile Val Gln Ala Pro 
                245                 250                 255     


Ser Glu Leu Val Asp Ser Glu His Pro Arg Leu Tyr Val Pro Ile Asp 
            260                 265                 270         


Val Glu Lys Phe Arg His Val Arg Asn Thr Thr Gly Leu Arg Ala Gly 
        275                 280                 285             


Asp Ala Leu Asp Leu Phe Ser Thr Thr 
    290                 295         


<210>  339
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  339

Met Ala Gly Lys Cys Thr Ile Pro Val Ile Asp Leu His Asn Leu Pro 
1               5                   10                  15      


Asn Gln Leu His Lys Leu Ile Ser Ala Cys Glu Asn Trp Gly Cys Phe 
            20                  25                  30          


Arg Leu Ile Asn His His Glu Ile Leu Ser Thr Lys Leu Met Phe Asp 
        35                  40                  45              


Met Lys Thr Val Val Arg Ser Leu Leu Asp Leu Pro Val Glu Ile Lys 
    50                  55                  60                  


Arg Arg Asn Ser Asp Val Ile Ala Arg Ser Gly Tyr Met Ala Pro Ser 
65                  70                  75                  80  


Ala Lys Asn Pro Leu Tyr Glu Ala Leu Gly Leu Tyr Asp Met Ala Lys 
                85                  90                  95      


Ser Gly Asp Val Glu Arg Phe Cys Glu Glu Leu Asp Ala Thr Arg Asp 
            100                 105                 110         


Gln Arg Tyr Ala Glu Ala Val His Glu Leu Phe Met Arg Ile Val Lys 
        115                 120                 125             


Lys Leu Ala Glu Gly Leu Gly Val Lys Arg Arg Asp Ile Gly Phe Glu 
    130                 135                 140                 


Asn Trp Pro Cys Gln Phe Arg Ile Asn Lys Tyr Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Ser Val Gly Ser Pro Gly Val Gln Leu His Thr Asp Ser Gly Phe Leu 
                165                 170                 175     


Thr Ile Leu Gln Asp Asp Glu Ile Val Gly Gly Leu Glu Val Met Asp 
            180                 185                 190         


Lys Thr Gly Lys Phe Ile Thr Val Asn Pro Trp Pro Asp Thr Leu Leu 
        195                 200                 205             


Val Asn Leu Gly Asp Met Ala Met Val Trp Ser Asn Gly Arg Phe Cys 
    210                 215                 220                 


Asn Val Lys His Arg Val Gln Cys Lys Glu Ala Lys Ile Arg Val Ser 
225                 230                 235                 240 


Ile Ala Ser Phe Leu Leu Gly Pro Arg Gly Ile Val Glu Pro Leu Ser 
                245                 250                 255     


Glu Leu Val Asp Asp Asp His Pro Leu Val Tyr Met Pro Thr Thr Tyr 
            260                 265                 270         


Glu Asp Tyr Arg Lys Leu Arg Phe Ser Thr Thr Leu Gln Ala Gly Glu 
        275                 280                 285             


Ala Leu Glu His Leu Tyr Thr Pro Arg Phe Lys Lys 
    290                 295                 300 


<210>  340
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  340

Met Thr Thr Leu Ser Glu Ala Tyr Arg Asn Ala Pro Val Ala Ser His 
1               5                   10                  15      


Gln Ile Thr Pro Leu Asp Phe Asp Ser Leu Asp Arg Val Pro Glu Ser 
            20                  25                  30          


His Ile Trp Ser Gln Ser Asp Glu Pro Gln Gln Asn Ile Gln Ser Gln 
        35                  40                  45              


Glu Pro Gln Glu Leu Ser Ile Pro Val Ile Asp Leu Thr Asp Pro Asn 
    50                  55                  60                  


Ala Leu Asp Leu Ile Gly Gln Ala Cys Lys Thr Trp Gly Ile Phe Gln 
65                  70                  75                  80  


Val Ile Asn His Gly Val Pro Leu Ala Leu Ile Lys Lys Val Glu Ser 
                85                  90                  95      


Glu Ser Arg Arg Leu Phe Gly Leu Pro Thr Asp Glu Lys His Lys Val 
            100                 105                 110         


Leu Arg Ser Ala Asn Gly Ala Thr Gly Tyr Gly Thr Ala Arg Ile Ser 
        115                 120                 125             


Pro Phe Phe Asp Lys Cys Met Trp His Glu Gly Phe Thr Ile Met Gly 
    130                 135                 140                 


Ser Cys Val Glu Asp Ala Asn Val Leu Trp Pro His Asp Tyr Lys Asn 
145                 150                 155                 160 


Phe Cys Glu Thr Met Asp Ala Tyr Gln Asn Glu Met Lys Leu Leu Thr 
                165                 170                 175     


His Lys Leu Leu His Leu Met Leu Gln Thr Leu Asn Leu Thr Gln Glu 
            180                 185                 190         


Glu Met Asn Trp Ala Ile Ser Ala Gln Asp Ser Gln Ala Ala Leu Gln 
        195                 200                 205             


Leu Asn Ser Tyr Pro Ser Cys Pro Asn Pro Ser Asn Ala Ile Gly Leu 
    210                 215                 220                 


Ala Pro His Thr Asp Ser Leu Leu Leu Thr Val Leu His Gln Gly Gly 
225                 230                 235                 240 


Ala Asn Gly Leu Glu Ile Phe Val Glu Gly Leu Gly Trp Ser Pro Val 
                245                 250                 255     


Asn Pro Val Asp Gly Ala Phe Val Val Asn Ile Gly Asp Leu Leu His 
            260                 265                 270         


Ile Leu Ser Asn Ala Thr Phe Gln Ala Val Asn His Arg Ala Met Val 
        275                 280                 285             


Asn Gln Ala Lys Gln Arg Ile Ser Val Ala Tyr Phe His Gly Pro Pro 
    290                 295                 300                 


Val Glu Ser Val Val Ala Pro Ser Ser Ser Phe Glu Asn Pro Cys Phe 
305                 310                 315                 320 


Arg Ser Met Leu Val Lys Glu Phe Ile Ser Leu Lys Ala Lys Asn Phe 
                325                 330                 335     


His Lys Ala Leu Ser Met Ile Arg Lys 
            340                 345 


<210>  341
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  341

Met Val Val Leu Thr Lys Pro Thr Leu Glu Gln Leu Ile Met Lys Thr 
1               5                   10                  15      


Thr Lys Pro Val Asn Pro Leu Thr Leu Ser Gln Ile Pro Val Val Asp 
            20                  25                  30          


Leu Ser Ser His Asp Ala Lys His Gln Ile Val Asn Ala Cys Gln Glu 
        35                  40                  45              


Phe Gly Phe Phe Lys Val Val Asn His Gly Ile Ser Met Asn Leu Ile 
    50                  55                  60                  


Asn Lys Leu Glu Ser Gln Ala Met Gln Phe Phe Leu Ser Pro Gln Asp 
65                  70                  75                  80  


Ile Lys Glu Lys Ala Gly Pro Ala Asp Pro Phe Gly Tyr Gly Asn Lys 
                85                  90                  95      


Lys Ile Gly Asn Asn Gly Asp Val Gly Trp Val Glu Tyr Leu Leu Leu 
            100                 105                 110         


Asn Ala Lys Pro Glu Thr Asp Ile Glu Lys Leu Val Ser Ala Phe Glu 
        115                 120                 125             


Glu His Pro Glu Val Phe Gln His Ala Leu Asn Asp Tyr Leu Thr Ser 
    130                 135                 140                 


Val Thr Lys Met Gly Cys Gly Ile Leu Glu Leu Met Ala Glu Gly Leu 
145                 150                 155                 160 


Glu Leu Glu Ala Lys Asn Val Phe Ser Lys Leu Leu Met Asp Asp Lys 
                165                 170                 175     


Ser Asp Ser Val Phe Arg Leu Asn Tyr Tyr Pro Pro Cys Pro Asp Val 
            180                 185                 190         


Gln Glu Asp Glu Ile Asn Gly Gly Asn Leu Ile Gly Phe Gly Glu His 
        195                 200                 205             


Thr Asp Pro Gln Ile Ile Ser Val Leu Arg Ser Asn Asp Thr Ser Gly 
    210                 215                 220                 


Leu Glu Ile Ala Leu Lys Asp Gly Thr Trp Val Ser Val Pro Ala Asp 
225                 230                 235                 240 


Ser Glu Ala Phe Phe Ile Asn Val Gly Asp Ser Leu Gln Val Met Thr 
                245                 250                 255     


Asn Gly Arg Phe Lys Ser Ile Lys His Arg Val Val Ala Asn Ser Lys 
            260                 265                 270         


Lys Ser Arg Met Ser Met Ile Tyr Phe Gly Gly Pro Pro Leu Asn Glu 
        275                 280                 285             


Lys Ile Ala Pro Leu Pro Ser Leu Ile Glu Arg Glu Glu Asp Ser Leu 
    290                 295                 300                 


Tyr Lys Glu Phe Thr Trp Phe Glu Tyr Lys Asn Thr Ala Phe Thr Ser 
305                 310                 315                 320 


Ser Leu Ser His Asn Arg Leu Gly Leu Tyr Glu Lys Leu Pro Ser Lys 
                325                 330                 335     


Ile 
    


<210>  342
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  342

Met Ala Ser Leu Ile Leu Pro Lys Leu Leu Val Val Asp Phe Thr Asn 
1               5                   10                  15      


Glu Asn Leu Lys Pro Gly Thr Ser Val Trp Ser Ser Thr Cys Asn Asp 
            20                  25                  30          


Ile Arg Val Ala Leu Glu Asn His Gly Cys Phe Ile Ala Leu Tyr Asp 
        35                  40                  45              


Gly Val Ser Ser Lys Leu Gln Asp Ser Val Phe Arg Ala Ala Glu Glu 
    50                  55                  60                  


Leu Phe Asp Leu Pro Thr Glu Thr Lys Ile Lys Asn Ile Gly Glu Lys 
65                  70                  75                  80  


Pro Tyr His Gly Tyr Leu Gly Gln Lys Pro Ile Ile Pro Leu His Glu 
                85                  90                  95      


Ala Leu Gly Ile Asp Tyr Ala Thr Asp Leu Glu Gly Ala Gln Ser Phe 
            100                 105                 110         


Thr Asp Ile Met Trp Pro Asp Gly Asn Gln Ser Phe Cys Glu Ala Ser 
        115                 120                 125             


Leu Ser Phe Ser Arg Ala Val Ala Lys Leu Asp Gln Thr Val Val Arg 
    130                 135                 140                 


Met Leu Phe Glu Ser Tyr Gly Val Glu Lys Gln Ser Ala Ser His Ile 
145                 150                 155                 160 


Glu Ser Thr Thr Tyr Leu Leu Arg Tyr Leu Lys Tyr Arg Ala Pro Glu 
                165                 170                 175     


Thr Asn Glu Thr Thr Ile Ala Met Pro Ser His Thr Asp Lys Thr Phe 
            180                 185                 190         


Leu Ser Ile Leu His Gln Asn Gln Val Ser Gly Leu Glu Ile Arg Ser 
        195                 200                 205             


Arg Asp Glu Glu Trp Ile Ser Val Gln Phe Pro Ala Ser Ser Phe Val 
    210                 215                 220                 


Val Met Ala Gly Asp Val Cys Lys Ala Trp Ser Asn Asn Arg Val Leu 
225                 230                 235                 240 


Ser Pro Asn His Lys Val Thr Met Asp Lys Gln Gly Lys Glu Thr Arg 
                245                 250                 255     


Tyr Thr Ile Ala Leu Phe Ser Tyr Leu Ser Lys Lys Val Gln Ile Pro 
            260                 265                 270         


Asp Glu Leu Val Asp Ala Asp His Pro Leu Gln Phe Lys Pro Phe Asp 
        275                 280                 285             


His Ile Asp Leu Leu Asn Phe Tyr Val Thr Glu Asn Gly Arg Lys Ser 
    290                 295                 300                 


Gln Asn Leu Leu Lys Asp Phe Cys Gly Val 
305                 310                 


<210>  343
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  343

Met Gly Ser Leu Ala Gln Pro Lys Gln Leu Pro Val Ile Asp Leu Cys 
1               5                   10                  15      


Leu Lys Tyr Leu Lys Ser Ser Ser Ser Ser Trp Val Ala Lys Cys Asp 
            20                  25                  30          


Glu Ile Thr Arg Ala Leu Glu Glu Tyr Gly Cys Phe Ile Ala Val Tyr 
        35                  40                  45              


Asp Gly Val Ser Gln Glu Leu His Asp Ala Thr Val Val Ala Ser Glu 
    50                  55                  60                  


Glu Leu Phe Asp Leu Pro Val Glu Val Lys Val Leu Asn Thr Lys Asp 
65                  70                  75                  80  


Ala Ala Gly His Gly Tyr Met Gly Asn Leu Pro Lys Ile Pro Leu Phe 
                85                  90                  95      


Glu Arg Leu Ser Ile Glu Asn Ala Thr Thr Pro Gln Gly Ala Glu Thr 
            100                 105                 110         


Phe Thr Lys Leu Met Trp Pro Ser Gly Asn Pro Ser Phe Cys Glu Ser 
        115                 120                 125             


Val Leu Ala Phe Thr Lys Val Leu Ala Glu Leu Glu Val Met Val Met 
    130                 135                 140                 


Arg Met Val Ala Lys Ser Leu Gly Ile Glu Gln Asp Tyr Val Lys Leu 
145                 150                 155                 160 


Leu Glu Phe Thr Thr Tyr Ile Leu Lys Phe Asn Lys Tyr Leu Ser Pro 
                165                 170                 175     


Pro Gly Gly Glu Arg Lys Val Gly Ile Tyr Pro His Thr Asp Lys Cys 
            180                 185                 190         


Phe Met Thr Thr Ile Gln Gln Gln Glu Asp Gly Lys Gly Leu Glu Val 
        195                 200                 205             


Lys Thr Lys Asp Gly Glu Trp Ile Glu Val Asp Leu Lys Pro Ala Phe 
    210                 215                 220                 


Phe Ile Val Met Ala Gly Asp Val Cys Thr Ala Trp Ser Asn Gly Arg 
225                 230                 235                 240 


Ile Glu Ala Pro Pro His Lys Val Met Met Glu Gly Asn Lys Asp Arg 
                245                 250                 255     


Ile Ser Leu Val Val Ser Ser Phe Ile Gln Asp Lys Val Glu Val Pro 
            260                 265                 270         


Gln Gly Leu Val Asp Glu Asp His Pro Leu Lys Phe Lys Ala Phe Asn 
        275                 280                 285             


His Tyr Lys Tyr Ile Glu Tyr His Asn Ser Thr Thr Asp Ala Asn Gly 
    290                 295                 300                 


Lys Arg Leu Lys Asp Ala Ile Arg Ser Tyr Cys Gly Ile 
305                 310                 315         


<210>  344
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  344

Met Ala Gly Cys Ala Glu Leu Pro Leu Ile Asp Leu Ser Ser Ser Asp 
1               5                   10                  15      


Arg Ile Ala Thr Ala Ile Ser Ile Arg Gln Ala Cys Met Glu Tyr Gly 
            20                  25                  30          


Phe Phe Tyr Leu Ile Asn His Gly Val Glu Glu Glu Leu Leu Gln Asn 
        35                  40                  45              


Val Val Asp Gln Ser Asn Lys Phe Phe Ser Leu Ser Ile Glu Glu Lys 
    50                  55                  60                  


Met Lys Leu Gly Arg Lys Asp Glu Asp Phe Gly Tyr Ala Pro Leu Tyr 
65                  70                  75                  80  


Ser Glu Asn His Asp His Ser Thr Ser Ser Lys Gly Asp Ser Lys Glu 
                85                  90                  95      


Thr Phe His Ile Gly Pro Leu Asp Gly Glu Glu Ser Leu Gln Asn Gln 
            100                 105                 110         


Trp Pro Ser Lys Glu Leu Leu Pro Ser Trp Arg Phe Val Met Glu Lys 
        115                 120                 125             


Tyr Tyr Lys Met Leu Leu Ser Thr Gly Lys Arg Leu Ser Ser Leu Ile 
    130                 135                 140                 


Ala Leu Ala Leu Asn Leu Glu Glu Asp Phe Phe Glu Lys Ile Gly Ala 
145                 150                 155                 160 


Val Asp Arg Pro Ser Ala Phe Leu Arg Leu Leu His Tyr Pro Gly Asp 
                165                 170                 175     


Met Gly Val Ser Asp Glu Val Val Tyr Gly Ala Ser Ala His Ser Asp 
            180                 185                 190         


Tyr Gly Met Met Thr Leu Leu Ala Thr Asp Ala Val Pro Gly Leu Gln 
        195                 200                 205             


Val Cys Arg Glu Lys Asn Lys His Pro Arg Thr Trp Glu Asn Val Thr 
    210                 215                 220                 


His Val Lys Gly Ala Phe Ile Val Asn Leu Gly Asp Met Met Glu Arg 
225                 230                 235                 240 


Trp Thr Asn Cys Leu Phe Arg Ser Thr Leu His Arg Val Met Pro Thr 
                245                 250                 255     


Gly Lys Glu Arg Tyr Ser Val Ala Phe Phe Met Asp Pro Asn Pro Asn 
            260                 265                 270         


Cys Ile Val Glu Cys Leu Lys Ser Cys Cys Ser Glu Ser Ser Pro Pro 
        275                 280                 285             


Arg Phe Pro Pro Ile Leu Ser Gly Asp Tyr Leu Arg Glu Arg Ile His 
    290                 295                 300                 


Asp Ala Tyr Ser Lys 
305                 


<210>  345
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  345

Met Gly Ser Leu Asp Glu Gly Trp Pro Glu Pro Val Val Cys Val Gln 
1               5                   10                  15      


Ser Leu Ser Asp Ser Gly Lys Leu Ser Ile Pro Asp Arg Tyr Ile Lys 
            20                  25                  30          


Pro Gln Pro Glu Arg Pro Ser Leu Ser Val Asn Asp Met Asn Ile Pro 
        35                  40                  45              


Ile Ile Asp Phe Asn Gly Leu Val Thr Ser Pro Glu Ala Thr Met Lys 
    50                  55                  60                  


Gln Ile Ser Lys Ala Cys Arg Glu Trp Gly Phe Phe Gln Leu Val Asn 
65                  70                  75                  80  


His Gly Val Arg Thr Asp Leu Val Asp Gly Val Arg Glu Thr Trp Arg 
                85                  90                  95      


Glu Phe Phe His Glu Pro Met Glu Val Lys Gln Lys Tyr Ala Asn Ser 
            100                 105                 110         


Pro Lys Thr Tyr Glu Gly Phe Gly Ser Arg Leu Gly Thr Glu Lys Asp 
        115                 120                 125             


Ala Ile Leu Asp Trp Asn Asp Tyr Tyr Tyr Leu His Tyr Arg Pro Pro 
    130                 135                 140                 


Cys Asn Thr Lys Trp Pro Asp Gln Pro Pro Ser Leu Arg Glu Val Met 
145                 150                 155                 160 


Glu Glu Tyr Thr Ser Glu Ile Leu Arg Leu Gly Ala Ala Leu Leu Lys 
                165                 170                 175     


Val Phe Ser Val Asn Leu Gly Leu Lys Glu Asp Ser Phe Gln Arg Ala 
            180                 185                 190         


Phe Gly Gly Asn Asp Phe Gly Ala Cys Leu Arg Ala Asn Phe Tyr Pro 
        195                 200                 205             


Lys Cys Pro Gln Pro Asp Leu Thr Leu Gly Leu Ser Ser His Ser Asp 
    210                 215                 220                 


Pro Gly Gly Met Ala Ile Leu Leu Pro Asp Glu Gln Val Cys Gly Leu 
225                 230                 235                 240 


Gln Val Arg Lys Asp Asp Gln Trp Val Thr Ile Lys Pro Glu Pro His 
                245                 250                 255     


Ala Ile Ile Val Asn Ile Gly Asp Gln Ile Gln Val Leu Ser Asn Ala 
            260                 265                 270         


Ile Tyr Lys Ser Val Glu His Arg Val Val Val Asn Pro Asn Lys Glu 
        275                 280                 285             


Arg Val Ser Leu Ala Tyr Phe Tyr Asn Pro Lys Ser Asp Met Leu Ile 
    290                 295                 300                 


Gln Pro Ile Ser Glu Leu Val Thr Ser Asn Lys Pro Ala Leu Tyr Leu 
305                 310                 315                 320 


Pro Met Thr Phe Glu Glu Tyr Arg Gly Phe Ile Arg Thr Lys Gly Pro 
                325                 330                 335     


Gln Gly Lys Phe Gln Val Glu Ser Leu Lys Ser Pro Arg 
            340                 345                 


<210>  346
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  346

Met Ala Asp Lys Cys Thr Ile Pro Val Ile Asp Leu His Asn Leu Pro 
1               5                   10                  15      


Asn Gln Leu Pro Glu Leu Ile Ser Ala Cys Glu Asn Trp Gly Cys Phe 
            20                  25                  30          


Arg Leu Ile Asn His His Lys Ile Leu Ser Thr Lys Leu Met Leu Glu 
        35                  40                  45              


Met Lys Thr Val Val Arg Ser Leu Leu Asp Leu Pro Val Glu Ile Lys 
    50                  55                  60                  


Arg Arg Ser Ser Asp Val Ile Ala Gly Ser Gly Tyr Met Ser Pro Ser 
65                  70                  75                  80  


Ala Lys Asn Arg Leu Tyr Glu Ala Leu Gly Leu Tyr Asp Met Ala Lys 
                85                  90                  95      


Ser Gly Asp Val Glu Arg Phe Cys Gln Glu Leu Asp Ala Thr Arg Asp 
            100                 105                 110         


Gln Arg Glu Ile Ile Met Arg Tyr Ala Glu Ala Val His Glu Leu Cys 
        115                 120                 125             


Met Arg Leu Val Lys Lys Leu Ala Glu Gly Leu Gly Val Lys Arg Glu 
    130                 135                 140                 


Asp Ile Gly Phe Glu Asn Trp Pro Cys Glu Phe Arg Phe Asn Lys Tyr 
145                 150                 155                 160 


Asn Phe Ile Pro Glu Ser Val Gly Ser Pro Gly Val Gln Leu His Thr 
                165                 170                 175     


Asp Ser Ala Phe Leu Thr Ile Leu Gln Asp Asp Glu Ser Val Gly Gly 
            180                 185                 190         


Leu Glu Val Leu Asp Lys Thr Gly Lys Phe Ile Thr Val Asn Pro Trp 
        195                 200                 205             


Pro Asp Thr Leu Leu Val Asn Leu Gly Asp Met Ala Met Val Trp Ser 
    210                 215                 220                 


Asn Gly Arg Phe Cys Asn Val Lys His Arg Val Gln Cys Lys Glu Ala 
225                 230                 235                 240 


Lys Ile Arg Val Ser Ile Ala Ser Phe Leu Leu Gly Pro Arg Gly Ile 
                245                 250                 255     


Val Glu Pro Leu Ser Glu Leu Val Asp Asp Asp His Pro Leu Val Tyr 
            260                 265                 270         


Met Pro Thr Thr Tyr Glu Asp Tyr Arg Lys Leu Arg Glu Ile Ile Met 
        275                 280                 285             


Arg Tyr Ala Glu Ala Val His Glu Leu Cys Met Arg Ile Met Lys Lys 
    290                 295                 300                 


Leu Ala Glu Gly Leu Gly Val Lys Arg Glu Asp Ile Gly Phe Glu Asn 
305                 310                 315                 320 


Trp Pro Cys Glu Phe Arg Phe Asn Lys Tyr Asn Phe Ile Pro Glu Ser 
                325                 330                 335     


Val Gly Ser Pro Gly Val Arg Leu His Thr Asp Ser Ala Phe Leu Thr 
            340                 345                 350         


Ile Leu Gln Asp Asp Glu Ser Val Gly Gly Leu Glu Val Met Asp Lys 
        355                 360                 365             


Thr Gly Lys Phe Ile Thr Val Asn Pro Trp Pro Asp Thr Leu Leu Val 
    370                 375                 380                 


Asn Leu Gly Asp Met Ala Thr Val Trp Ser Asn Gly Arg Phe Cys Asn 
385                 390                 395                 400 


Val Lys His Arg Val Gln Cys Lys Glu Ala Lys Ile Arg Val Ser Ile 
                405                 410                 415     


Ala Ser Phe Leu Leu Gly Pro Arg Gly Ile Val Glu Pro Leu Ser Lys 
            420                 425                 430         


Leu Val Asp Asp Gly His Pro Leu Val Tyr Met Pro Thr Thr Tyr Glu 
        435                 440                 445             


Asp Tyr Arg Lys Leu Arg Phe Ser Thr Lys Leu Gln Ala Gly Glu Ala 
    450                 455                 460                 


Leu Glu His Leu Tyr Thr Pro Arg Phe Lys Lys 
465                 470                 475 


<210>  347
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  347

Met Glu Asn Pro Ser His Ser Gln Thr Thr Pro Leu Ser Tyr Pro Pro 
1               5                   10                  15      


Cys Phe Arg Pro Asn Thr Pro Gln Leu Ser His Gln Thr Asn Thr Thr 
            20                  25                  30          


Arg Asp Gln Lys Leu Glu Leu Glu His Asp Pro Leu Pro Val Ile Asp 
        35                  40                  45              


Phe Gln His Ile Asp Leu Met Lys Leu Glu Glu Ala Cys Met Asp Trp 
    50                  55                  60                  


Gly Ile Phe Arg Leu Val Asn His Gly Ile Pro Leu Thr Leu Met Ser 
65                  70                  75                  80  


Lys Val His Glu His Val Ser Asn Val Phe Asp Ile Gly Phe Glu Thr 
                85                  90                  95      


Lys Gln Lys Met Phe Glu Thr Ile Pro Ala Ser Val Leu Ser Tyr Phe 
            100                 105                 110         


Trp Gly Thr Pro Ala Leu Thr Pro Ser Gly Val Ala Leu Tyr Lys Asp 
        115                 120                 125             


Gly Asp Lys Gln Ser Asp Gln Gly Thr Ile Ser Tyr Asn Trp Val Glu 
    130                 135                 140                 


Gly Leu Asn Tyr Pro Leu Ser Gln Gly Ser Leu Asp Phe Cys Leu Asp 
145                 150                 155                 160 


Gln Tyr Pro Met Ile Arg Asp Met Arg Thr Leu Leu Glu Glu Tyr Gly 
                165                 170                 175     


Val His Gln Glu Arg Ile Ala Lys Ser Ile Phe Gly Ala Met Ser Gln 
            180                 185                 190         


Asn Leu Ser Ile Cys Glu Glu Asn Glu Gly Tyr Leu Ser Pro Ser Thr 
        195                 200                 205             


Gly Ile Leu Arg Val Tyr Arg Tyr Pro Arg Ser Phe Phe Asp Lys Ser 
    210                 215                 220                 


Thr Lys Val Trp Gly Met Glu Ala His Thr Asp Ser Ser Val Val Thr 
225                 230                 235                 240 


Ile Leu Asn Gln Tyr Glu Val Glu Gly Leu Gln Val Leu Ser Pro Lys 
                245                 250                 255     


Asp Glu Trp Ile Asp Ala Lys Pro Ile Pro Asn Thr Leu Val Val His 
            260                 265                 270         


Leu Gly Asp Met Met Gln Ala Ile Ser Asp Asp Lys Tyr Lys Ser Val 
        275                 280                 285             


Lys His Arg Val Met Val Asn Arg Glu Arg Glu Arg Ile Ser Met Gly 
    290                 295                 300                 


Tyr Phe Val Phe Pro Asp Asn Asp Cys Val Ile Arg Ser Ser Asn Tyr 
305                 310                 315                 320 


Lys Pro Phe Thr Tyr Leu Asp Phe Arg Ser Gln Val Gln Asp Asp Ile 
                325                 330                 335     


Lys Asn Leu Gly Val Lys Val Gly Leu Ser Arg Phe Lys Leu Asn Lys 
            340                 345                 350         


Tyr Phe Tyr Ile 
        355     


<210>  348
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  348

Met Val Ala Ile Ser Glu Pro Gln Val Glu Leu Phe Phe Pro Lys Pro 
1               5                   10                  15      


Cys Lys Gln Asn Ser Lys Asn Asn Pro Leu Phe Met Pro Thr Ile Pro 
            20                  25                  30          


Ile Ile Asp Leu Ser Lys Pro Asp Leu Lys His Leu Leu Val Lys Ala 
        35                  40                  45              


Cys Gln Glu Phe Gly Phe Phe Lys Val Ile Asn His Gly Val Pro Ile 
    50                  55                  60                  


Lys Cys Ile Asn Lys Leu Glu Ser Glu Ala Ile Lys Phe Phe Asn Ser 
65                  70                  75                  80  


Pro Leu Ser Ala Lys Gln Lys Ala Gly Pro Pro Asp Pro Phe Gly Tyr 
                85                  90                  95      


Gly Asn Lys Ser Ile Gly Gln Asn Gly Asp Met Gly Trp Val Glu Tyr 
            100                 105                 110         


Leu Leu Leu Asn Pro Lys Leu Glu Ser His Tyr Lys Asn Pro Thr Ile 
        115                 120                 125             


Ser Ile Leu Glu Asp Lys Pro Glu Lys Phe Lys Tyr Thr Val Asp Asp 
    130                 135                 140                 


Tyr Val Thr Ser Val Lys Lys Met Thr Cys Ala Ile Leu Glu Leu Leu 
145                 150                 155                 160 


Ala Asp Glu Leu Asn Leu Pro Gln Asn Val Phe Ser Asn Met Leu Arg 
                165                 170                 175     


Asp Glu Gln Ser Asp Ser Val Phe Arg Val Asn Tyr Tyr Pro Pro Cys 
            180                 185                 190         


Pro Leu Phe Gln Glu His Glu Met Lys Gly Lys Lys Leu Ile Gly Phe 
        195                 200                 205             


Gly Glu His Thr Asp Pro Gln Ile Ile Ser Val Leu Arg Ser Asn Asn 
    210                 215                 220                 


Thr Ser Gly Leu Glu Ile Leu Leu Lys Asp Gly Asn Trp Met Ser Val 
225                 230                 235                 240 


Pro Pro Asp Thr Asn Ser Phe Phe Val Asn Val Gly Asp Ser Leu Gln 
                245                 250                 255     


Val Met Thr Asn Gly Arg Phe Lys Ser Val Lys His Arg Val Val Ala 
            260                 265                 270         


Asn Ser Leu Lys Ser Arg Leu Ser Met Ile Tyr Phe Gly Gly Pro Pro 
        275                 280                 285             


Leu Cys Gln Lys Ile Ala Pro Leu His Leu Leu Met Lys Arg Asp Glu 
    290                 295                 300                 


Ala Ser Leu Tyr Lys Glu Phe Thr Trp Tyr Glu Tyr Lys Lys Ser Ala 
305                 310                 315                 320 


Phe Asn Ser Arg Leu Ser Asp Asn Arg Leu Cys Arg Phe Glu Lys Asn 
                325                 330                 335     


Arg Asn Val Leu Ile Lys Val Pro Ser Leu Lys Val Glu Leu Glu Thr 
            340                 345                 350         


Ser Asn 
        


<210>  349
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  349

Met Ala Pro Ser Phe Asn Asp Glu Asn Ser Leu Phe Asp Phe Val Val 
1               5                   10                  15      


Asn Glu Gly Asn Gly Val Lys Gly Met Val Asp Ser Gly Leu Met Glu 
            20                  25                  30          


Val Pro Ser Arg Tyr Ile Gln Pro Pro His Asn Arg Ile Ser Lys Gln 
        35                  40                  45              


His Ala Thr Val Ser Ile Asp Gln Ser Met Thr Ile Asp Leu Ser Glu 
    50                  55                  60                  


Leu Asp Gly Pro Asn His Asp Gln Val Val Lys Ser Ile Ala His Ala 
65                  70                  75                  80  


Ala Glu Thr Leu Gly Phe Phe Gln Val Val Asn His Gly Val Pro Leu 
                85                  90                  95      


Glu Leu Leu Asp Ser Leu Lys Val Ala Ala His Gln Phe Phe Asn Gln 
            100                 105                 110         


Pro Val Glu Lys Lys Ala Val Tyr Leu Lys Gly Val Ser Pro Ser Pro 
        115                 120                 125             


Met Val Lys Tyr Gly Thr Ser Phe Asn Pro Asp Lys Glu Lys Ala Leu 
    130                 135                 140                 


Glu Trp Lys Asp Tyr Val Ser Met Ile Tyr Thr Asn Asp Asp Asp Ala 
145                 150                 155                 160 


His Met Phe Trp Pro Lys Glu Cys Lys Glu Val Ala Leu Glu Phe Ile 
                165                 170                 175     


Lys Thr Thr Asn Gln Met Val Gln Lys Leu Leu Gln Ala Leu Ile Thr 
            180                 185                 190         


Ser Leu Gly Val Lys Leu Asp Asp Ser Arg Leu Asn Ala Phe Ile Gly 
        195                 200                 205             


Phe Arg Met Val Asn Met Asn Tyr Tyr Pro Thr Cys Pro Asn Pro Asp 
    210                 215                 220                 


Leu Thr Val Gly Val Gly Lys His Ser Asp Met Gly Thr Leu Thr Val 
225                 230                 235                 240 


Leu Leu Gln Asp Gly Ile Gly Gly Leu Tyr Val Lys Lys Gly Asp Asp 
                245                 250                 255     


Ser Ser Pro Gly Asn Glu Glu Trp Val Gly Ile Ala Pro Ala His Gly 
            260                 265                 270         


Ala Leu Val Ile Asn Val Gly Asp Thr Leu Gln Ile Leu Ser Asn Gly 
        275                 280                 285             


Arg Tyr Lys Ser Ala Glu His Arg Val Arg Thr Thr Ser Val Glu Ser 
    290                 295                 300                 


Arg Val Ser Ile Pro Ile Phe Thr Ala Pro Leu Pro Met Thr Lys Ile 
305                 310                 315                 320 


Gly Pro Leu Ala Glu Leu Val Ala Arg Asp Gly Val Ala Arg Tyr Arg 
                325                 330                 335     


Glu Leu Leu Phe Glu Glu Tyr Met Asn Asn Phe Phe Ala Asn Ser His 
            340                 345                 350         


Asp Gly Lys Lys Ser Leu Asp Phe Ala Ser Thr Thr 
        355                 360                 


<210>  350
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  350

Met Gly Leu Glu Gly Tyr Ile Gln Leu Pro Val Ile Asp Phe Ser Ala 
1               5                   10                  15      


Ile Asn Asn Gln Asn Pro Asp Thr His Asp Tyr Asp Ser Val Lys Thr 
            20                  25                  30          


Lys Val Leu Glu Ala Phe Gln Glu Tyr Gly Cys Phe Gln Ala Ser Ile 
        35                  40                  45              


Val Gly Ile Ser Pro Glu Leu Gln Asn Ser Val Tyr Asp Val Met Lys 
    50                  55                  60                  


Gln Leu Phe Asp Leu Pro Leu Glu Thr Lys Ser Lys Asn Thr Ser Thr 
65                  70                  75                  80  


Gln Met Phe His Gly Tyr Phe Gly Asn Ser Pro Leu Leu Pro Leu Tyr 
                85                  90                  95      


Glu Ser Met Gly Ile Asp Asp Ala Tyr Asn Pro Glu His Val Glu Asn 
            100                 105                 110         


Phe Thr Asn Leu Met Trp Pro Gln Gly Asn Pro Gln Ala Cys Lys His 
        115                 120                 125             


Ile Gln Thr Tyr Ala Lys Lys Leu Trp Lys Phe Asp Ala Met Val Lys 
    130                 135                 140                 


Lys Met Leu Phe Gln Ser Leu Asn Leu Glu Lys Tyr Leu Asn Glu Gln 
145                 150                 155                 160 


Ala Glu Lys Thr Asn Tyr Val Phe Lys Leu Met Lys Tyr Arg Val Pro 
                165                 170                 175     


Glu Pro Asn Asp Ser Asn Leu Gly Leu His Ala His Ala Asp Ala Gly 
            180                 185                 190         


Val Met Thr Ile Leu His Gln Lys Asp Val Glu Gly Leu Glu Ile Gln 
        195                 200                 205             


Thr Lys Tyr Asp Glu Trp Leu Lys Val Lys Leu Ser Pro Asn Met Phe 
    210                 215                 220                 


Ile Ile Met Ala Gly Glu Thr Leu Asn Val Trp Leu Asn Gly Arg Leu 
225                 230                 235                 240 


His Val Pro Ile His Arg Val Met Met Arg Ala Thr Lys Thr Arg Phe 
                245                 250                 255     


Ser Leu Ala Phe Phe Gln Leu Pro Leu Ala Gly Asn Ile Val Lys Pro 
            260                 265                 270         


Met Glu Glu Met Val Asp Asp Asp His Pro Leu Leu Phe Lys Pro Phe 
        275                 280                 285             


Asp Tyr Gly Glu Phe Ile Gln Phe Tyr Ile Thr Gly Gly Thr Gly Ile 
    290                 295                 300                 


Gln Asn Tyr Ala Val Lys Ala Tyr Cys Gly Val 
305                 310                 315 


<210>  351
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  351

Met Val Val Leu Thr Lys Pro Thr Leu Glu Gln Leu Ile Met Lys Thr 
1               5                   10                  15      


Thr Lys Pro Val Asn Pro Leu Thr Leu Ser Gln Ile Pro Ile Val Asp 
            20                  25                  30          


Leu Ser Ser His Asp Ala Lys His Gln Ile Val Asn Ala Cys Gln Glu 
        35                  40                  45              


Phe Gly Phe Phe Lys Val Val Asn His Gly Ile Ser Met Asn Leu Ile 
    50                  55                  60                  


Lys Lys Leu Glu Ser Gln Ala Met Gln Phe Phe Leu Ser Pro Gln Asp 
65                  70                  75                  80  


Ile Lys Glu Lys Ala Gly Pro Ala Asp Pro Phe Gly Tyr Gly Asn Lys 
                85                  90                  95      


Lys Ile Gly Asn Asn Gly Asp Val Gly Trp Val Glu Tyr Leu Leu Leu 
            100                 105                 110         


Asn Val Lys Pro Glu Thr Asp Ile Glu Lys Leu Val Ser Ala Phe Glu 
        115                 120                 125             


Glu His Pro Glu Val Phe Gln His Ala Leu Asn Asp Tyr Leu Thr Ser 
    130                 135                 140                 


Val Thr Lys Met Gly Cys Gly Ile Leu Glu Leu Met Ala Glu Gly Leu 
145                 150                 155                 160 


Glu Leu Glu Ser Lys Asn Ala Phe Ser Lys Leu Leu Met Asp Asp Lys 
                165                 170                 175     


Ser Asp Ser Val Phe Arg Leu Asn Tyr Tyr Pro Pro Cys Pro Asp Val 
            180                 185                 190         


Gln Glu Asp Glu Ile Asn Gly Gly Asn Leu Ile Gly Phe Gly Glu His 
        195                 200                 205             


Thr Asp Pro Gln Ile Ile Ser Val Leu Arg Ser Asn Asp Thr Ser Gly 
    210                 215                 220                 


Leu Glu Ile Ala Leu Lys Asp Gly Thr Trp Val Ser Val Pro Ala Asp 
225                 230                 235                 240 


Ser Glu Ala Phe Phe Ile Asn Val Gly Asp Ser Leu Gln Val Met Thr 
                245                 250                 255     


Asn Gly Arg Phe Lys Ser Ile Lys His Arg Val Val Ala Asn Ser Lys 
            260                 265                 270         


Lys Ser Arg Met Ser Met Ile Tyr Phe Gly Gly Pro Pro Leu Asn Glu 
        275                 280                 285             


Lys Ile Ala Pro Leu Pro Ser Leu Ile Glu Arg Glu Glu Asp Ser Leu 
    290                 295                 300                 


Tyr Lys Glu Phe Thr Trp Phe Glu Tyr Lys Asn Thr Ala Phe Thr Ser 
305                 310                 315                 320 


Ser Leu Ser His Asn Arg Leu Gly Leu Tyr Glu Lys Leu Pro Ser Lys 
                325                 330                 335     


Ile 
    


<210>  352
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  352

Met Gly Ser Glu Ala Pro Phe Gln Leu Pro Val Val Asp Phe Ser Ala 
1               5                   10                  15      


Leu Asn Lys Gln Asn Pro Asp Ile Val Ile Trp Glu Thr Ala Lys Thr 
            20                  25                  30          


Lys Ala Ile Glu Ala Leu Gln Glu Tyr Gly Cys Phe Glu Ala Thr Phe 
        35                  40                  45              


Asp Glu Ile Ser Pro Asp Leu Gln Asn Ser Val Phe Ser Glu Leu Glu 
    50                  55                  60                  


Asn Leu Phe Asn Leu Pro Leu Glu Thr Lys Gln Lys Asn Ala Asn Asp 
65                  70                  75                  80  


Arg Glu Phe His Gly Tyr Ile Gly Gln Ile Pro Phe Met Pro Leu Tyr 
                85                  90                  95      


Glu Ser Met Gly Ile Asp Thr Pro Tyr Val Gln Glu Lys Val Asp Glu 
            100                 105                 110         


Phe Thr Asn Val Met Trp Pro Gln Gly Asn Ser Lys Phe Ser Lys Ser 
        115                 120                 125             


Ile Gln Ala Tyr Ser Lys Lys Leu Trp Glu Leu Asp Glu Met Val Lys 
    130                 135                 140                 


Lys Met Val Phe Glu Gly Leu Asn Leu Arg Lys Tyr Leu Glu Glu His 
145                 150                 155                 160 


Leu Glu Ala Thr Ser Tyr His Leu Lys Val Met Lys Tyr Arg Val Ala 
                165                 170                 175     


Asp Pro Ser Glu Ser Thr Met Gly Leu Asp Ser His Ala Asp Thr Ser 
            180                 185                 190         


Ile Leu Thr Ile Leu His Gln Asn Gly Val Gln Gly Leu Glu Leu Arg 
        195                 200                 205             


Thr Lys Asp Glu Thr Trp Val Thr Val Asn Val Ser Pro Asn Ser Phe 
    210                 215                 220                 


Val Val Met Ala Gly Glu Ser Phe Asn Val Leu Ser Asn Gly Arg Leu 
225                 230                 235                 240 


His Ala Pro Phe His Arg Val Val Met Asn Ala Asn Lys Thr Arg Leu 
                245                 250                 255     


Ser Val Gly Leu Phe Ser Met Pro Lys Val Gly Ser Ile Val Lys Pro 
            260                 265                 270         


Pro Lys Glu Met Val Asp Glu Glu His Pro Leu Leu Phe Lys Pro Phe 
        275                 280                 285             


Asp Tyr Gly Glu Phe Met Asp Tyr Phe Cys Met Ala Gly Val Lys Lys 
    290                 295                 300                 


Asp Thr Tyr Gly Leu Lys Thr Tyr Cys Gly Leu Ser Ile 
305                 310                 315         


<210>  353
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  353

Met Pro Thr Pro Ala Ile Pro Thr Val Asn Leu Ser Pro Phe Phe Thr 
1               5                   10                  15      


Ala Gly Asp Asp Ser Gly Arg Lys Lys Ala Lys Asp Ile Ile Ala Glu 
            20                  25                  30          


Ala Cys Ala Asp Tyr Gly Phe Phe Gln Ile Val Asn His Gly Val Pro 
        35                  40                  45              


Leu Glu Leu Met Asn Gln Ala Met Asp Leu Ser Lys Thr Phe Phe Ser 
    50                  55                  60                  


Tyr Ser Asp Glu Val Lys His Lys Ser Ser Ser Gly Pro Asp Ala Pro 
65                  70                  75                  80  


Leu Pro Ala Gly Tyr Asn Lys Gln Pro Asp His Ser Pro Asp Lys Ser 
                85                  90                  95      


Glu Tyr Leu Leu Met Phe Pro Pro Glu Ser Pro Phe Asn Ile Leu Pro 
            100                 105                 110         


Asp Asn Pro Pro Glu Phe Arg Lys Thr Leu Glu Glu Met Phe Thr Tyr 
        115                 120                 125             


Phe Val Lys Thr Gly Gln Ile Leu Glu Asp Ile Ile Ser Glu Cys Leu 
    130                 135                 140                 


Asp Leu Pro Leu Asn Phe Leu Lys Glu Tyr Asn Asn Asp Arg Ser Trp 
145                 150                 155                 160 


Asp Phe Met Val Thr Leu Arg Tyr Lys Pro Ala Thr Glu Thr Glu Asn 
                165                 170                 175     


Asn Gly Ile Thr Glu His Glu Asp Gly Asn Leu Ile Thr Met Val Leu 
            180                 185                 190         


Gln Glu Asp Val Gly Gly Leu Glu Val Cys Lys Asn Gly Glu Trp Ile 
        195                 200                 205             


Pro Val Ile Pro Ser Lys Gly Thr Leu Val Val Asn Ile Gly Asp Val 
    210                 215                 220                 


Ile Gln Val Leu Ser Asn Lys Lys Phe Lys Ser Ala Thr His Arg Val 
225                 230                 235                 240 


Val Arg Pro Lys Glu Arg Ser Arg His Ser Tyr Val Phe Phe Tyr Ser 
                245                 250                 255     


Leu Gln Gly Asp Lys Trp Val Glu Pro Leu Pro Gln Phe Ser Gln Glu 
            260                 265                 270         


Ile Gly Ala Lys Pro Lys Tyr Lys Gly Phe Tyr Tyr Lys Asp Tyr Gln 
        275                 280                 285             


Ala Leu Arg Leu Arg Asn Lys Thr His Pro Pro Ser Asn Pro Glu Asp 
    290                 295                 300                 


Ile Ala Arg Leu Thr Met Tyr Glu Ile 
305                 310             


<210>  354
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  354

Met His Lys Leu Pro Ser Ile Asp Phe Thr Asn Lys Lys Asn Leu Lys 
1               5                   10                  15      


Pro Gly Ser Thr Ser Trp Leu Ala Thr Ala Leu Glu Ala Thr Arg Ala 
            20                  25                  30          


Leu Glu Glu Tyr Gly Cys Phe Ile Ala Glu Phe Asp Lys Val Thr Pro 
        35                  40                  45              


Glu Leu Asn Asp Ala Val Phe His Gly Leu Glu Asp Leu Phe Asp Ile 
    50                  55                  60                  


Pro Ile Glu Thr Lys Val Leu Asn Lys Ser Thr Lys Pro Leu Tyr Gly 
65                  70                  75                  80  


Tyr Val Gly Gln Ile Pro Phe Ile Pro Leu Tyr Glu Ser Met Gly Phe 
                85                  90                  95      


Asp Tyr Ser Asn Thr Leu Asp Gly Val Arg Ser Phe Thr Glu Val Met 
            100                 105                 110         


Trp Pro Asn Gly Asn Glu Ala Phe Ser Leu Arg Thr Lys Thr Cys Gly 
        115                 120                 125             


Asp Val Ser Ala Leu Glu Lys Tyr Gly Cys Phe Met Ala Thr Tyr Asp 
    130                 135                 140                 


Gly Val Ser Gln Glu Leu His Asp Ala Ile Phe Asp Ala Ser His Asp 
145                 150                 155                 160 


Leu Phe Asp Leu Pro Thr Glu Val Lys Val Leu Asn Thr Ser Asp Thr 
                165                 170                 175     


Pro Ser His Gly Tyr Val Gly Gln Ile Pro Val Ile Pro Leu Tyr Glu 
            180                 185                 190         


Gly Leu Ala Leu Lys Met Gln Pro Leu Gln Met Glu Leu Gln Asp Ser 
        195                 200                 205             


Gln Asn Ser Cys Gly Pro Gln Glu Met Lys Phe Ser Gly Met Ala Ile 
    210                 215                 220                 


Ala Glu Leu Asp Gln Ile Val Met Lys Met Thr Ala Lys Ser Tyr Gly 
225                 230                 235                 240 


Val Lys Glu His Tyr Glu Pro Leu Leu Gly Thr Thr Thr Tyr Leu Leu 
                245                 250                 255     


Lys Leu Ile Lys Tyr Leu Ser Thr Gln Gly Asp Glu Arg Asn Leu Gly 
            260                 265                 270         


Ile Val Pro His Thr Asp Lys Thr Phe Met Ser Ile Leu His Gln Asp 
        275                 280                 285             


Glu Val Lys Gly Leu Glu Ile Lys Thr Lys Asp Gly Glu Trp Ile Glu 
    290                 295                 300                 


Tyr Asp Pro Ser Pro Ser Ser Phe Val Val Met Ala Gly Asp Gly Cys 
305                 310                 315                 320 


Met Ala Trp Thr Asn Gly Lys Ile Glu Ala Ser Cys His Arg Val Met 
                325                 330                 335     


Met Gln Gly Asn Lys Glu Arg Phe Ser Leu Gly Leu Phe Thr Phe Ile 
            340                 345                 350         


Arg Asn Ile Lys Ile Glu Met Pro Gln Glu Leu Val Asp Glu Asn His 
        355                 360                 365             


Pro Leu Lys Phe Lys Ala Phe Asp Pro Leu Gln Ile Ser Pro Leu Ser 
    370                 375                 380                 


Cys Ser Arg 
385         


<210>  355
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  355

Met Gly Ser Leu Asp Asp Tyr Trp Pro Glu Pro Val Val Cys Val Gln 
1               5                   10                  15      


Ser Leu Ser Asp Ser Gly Asn Leu Ser Ile Pro Asp Arg Tyr Ile Lys 
            20                  25                  30          


Pro Gln Pro Glu Arg Pro Ser Leu Ser Val Asn Asp Met Asn Ile Pro 
        35                  40                  45              


Val Ile Asp Phe Asn Gly Leu Val Thr Ser Pro Glu Ala Thr Met Lys 
    50                  55                  60                  


Gln Ile Ser Lys Ala Cys Arg Glu Trp Gly Phe Phe Gln Leu Val Asn 
65                  70                  75                  80  


His Gly Val Arg Thr Asp Leu Val Asp Gly Val Arg Glu Thr Trp Arg 
                85                  90                  95      


Glu Phe Phe His Glu Pro Met Glu Val Lys Gln Lys Tyr Ala Asn Ser 
            100                 105                 110         


Pro Lys Thr Tyr Glu Gly Phe Gly Ser Arg Leu Gly Thr Glu Lys Gly 
        115                 120                 125             


Ala Ile Leu Asp Trp Asn Asp Tyr Tyr Tyr Leu His Tyr Arg Pro Pro 
    130                 135                 140                 


Cys Asn Thr Lys Trp Pro Asp Gln Pro Pro Ser Leu Arg Glu Val Met 
145                 150                 155                 160 


Glu Glu Tyr Thr Ser Glu Ile Leu Arg Leu Gly Ala Ala Leu Leu Lys 
                165                 170                 175     


Val Phe Ala Val Asn Leu Gly Leu Lys Glu Asp Ser Phe Gln Ser Ala 
            180                 185                 190         


Phe Gly Gly Asn Asp Phe Gly Ala Cys Leu Arg Ala Asn Phe Tyr Pro 
        195                 200                 205             


Lys Cys Pro Gln Pro Asp Leu Thr Leu Gly Leu Ser Ser His Ser Asp 
    210                 215                 220                 


Pro Gly Gly Met Ala Ile Leu Leu Pro Asp Glu Gln Val Cys Gly Leu 
225                 230                 235                 240 


Gln Val Arg Lys Asp Asp Gln Trp Val Thr Ile Lys Pro Glu Pro His 
                245                 250                 255     


Ala Ile Ile Val Asn Ile Gly Asp Gln Ile Gln Val Leu Ser Asn Ala 
            260                 265                 270         


Ile Tyr Lys Ser Val Glu His Arg Val Val Val Asn Pro Asn Lys Glu 
        275                 280                 285             


Arg Val Ser Leu Ala Tyr Phe Tyr Asn Pro Lys Ser Asp Met Leu Ile 
    290                 295                 300                 


Gln Pro Ile Ser Glu Leu Val Thr Ser Asn Lys Pro Ala Leu Tyr Leu 
305                 310                 315                 320 


Pro Met Thr Phe Glu Glu Tyr Arg Gly Phe Ile Arg Thr Lys Gly Pro 
                325                 330                 335     


Gln Asp Val Lys Arg Tyr Lys His Gln Ile Thr Phe Glu Arg Pro Ser 
            340                 345                 350         


Asp Lys Asn Thr Leu Lys Ile Pro Ser Glu Thr Leu Glu Pro Asn Asp 
        355                 360                 365             


Val Lys Trp Asn Pro Ile His Asn Leu Ile Lys Arg Leu Arg Glu Asp 
    370                 375                 380                 


Ile Ala Asn Val Met Thr Ile 
385                 390     


<210>  356
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  356

Met Asn Asn Lys Gln Val Gln Glu Ile Ala Ala Asp Cys Glu Gln Leu 
1               5                   10                  15      


Pro Glu Arg Tyr Ile Arg Lys Gln Asp Glu Glu Tyr Gly Ala Asn Val 
            20                  25                  30          


Thr Lys Ser Asp Val Thr Ser Ala Val Ile Pro Val Ile Asp Leu Ser 
        35                  40                  45              


Leu Leu Ile Ser Ser Pro Leu Glu Leu Asp Lys Leu Lys Ser Ala Val 
    50                  55                  60                  


Ile Thr Trp Gly Cys Phe Gln Ala Ile Asn His Gly Ile Asp Gly Ser 
65                  70                  75                  80  


Phe Leu Glu Lys Val Arg Glu Ile Ser Lys Leu Phe Phe Lys Leu Pro 
                85                  90                  95      


Ala Asp Glu Lys Lys Lys Tyr Leu Arg Glu Glu Asn Asp Val Glu Gly 
            100                 105                 110         


Tyr Gly Asn Asp Met Val Leu Ser Glu Asn Gln Thr Leu Asp Trp Thr 
        115                 120                 125             


Asp Arg Leu Tyr Leu Thr Ala Leu Pro Gln Asp Gln Gln Arg Leu Gln 
    130                 135                 140                 


Phe Trp Pro Gln Asn Pro Thr His Phe Arg Glu Ile Leu Asp Glu Tyr 
145                 150                 155                 160 


Ser Ser Lys Ile Gln Leu Val Asn Glu Val Val Leu Lys Ala Leu Ala 
                165                 170                 175     


Arg Ser Leu Asn Leu Glu Glu Asp Cys Phe Leu Asn Gln Tyr Gly Thr 
            180                 185                 190         


Thr Ala Lys Met Gln Ala Arg Phe Asn Tyr Tyr Pro Pro Cys Pro Trp 
        195                 200                 205             


Pro Glu Lys Val Leu Gly Val Lys Pro His Ala Asp Ser Ser Ala Ile 
    210                 215                 220                 


Thr Val Leu Leu Gln Asp Lys Glu Val Glu Gly Leu Gln Leu Leu Lys 
225                 230                 235                 240 


Asp Asp Gln Trp Val Arg Val Pro Ile Val Pro Asp Ala Leu Thr Ile 
                245                 250                 255     


Asn Val Gly Asp Gln Ile Glu Ile Met Ser Asn Gly Ile Phe Lys Ser 
            260                 265                 270         


Pro Val His Arg Val Phe Val Asn Ser Lys Asn Glu Arg Met Thr Leu 
        275                 280                 285             


Ala Met Phe Cys Met Pro Gln Thr Glu Lys Asp Ile Gly Pro Val Asp 
    290                 295                 300                 


Gly Leu Ile Thr Asp Glu Arg Pro Arg Leu Tyr Lys Asn Val Thr Phe 
305                 310                 315                 320 


Thr Leu Asp Phe Phe Phe Lys Asn Tyr Gln Gln Gly Arg Arg Ala Ile 
                325                 330                 335     


Asp Ala Cys Arg Ile 
            340     


<210>  357
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  357

Met Ala Ser Thr Leu Gln Ser Trp Pro Glu Pro Val Val Arg Val Gln 
1               5                   10                  15      


Ser Leu Ser Asp Ser Gly Ile Asn Ala Ile Pro Asp Cys Tyr Val Lys 
            20                  25                  30          


Ala Ile Tyr Asp Arg Pro Ser Ser Leu Asp Asn Ile Ser Ser Ile Glu 
        35                  40                  45              


Ala Asn Asp Ile Pro Ile Ile Asn Leu Ala Asn Leu Tyr Ala Asn Asp 
    50                  55                  60                  


Pro Ser Ile Arg Lys Thr Thr Met Asp Leu Ile Ser Asp Ala Cys Arg 
65                  70                  75                  80  


Glu Trp Gly Met Phe Gln Val Ile Asn His Gly Val Ser His His Leu 
                85                  90                  95      


Met Ala Ala Thr Lys Arg Val Trp Arg Glu Phe Phe His Leu Pro Leu 
            100                 105                 110         


Asp Met Lys Gln Thr Tyr Ala Asn Ser Pro Ala Thr Tyr Glu Gly Tyr 
        115                 120                 125             


Gly Ser Arg Val Gly Val Glu Lys Gly Ala Lys Leu Asp Trp Ser Asp 
    130                 135                 140                 


Tyr Phe Phe Leu Gln Phe Leu Pro Ala Ser Met Arg Asp Glu Ser Lys 
145                 150                 155                 160 


Trp Pro Thr Gln Pro Ser Ser Cys Arg Glu Leu Val Ala Glu Tyr Asn 
                165                 170                 175     


Glu Glu Val Leu Lys Leu Cys Ser Arg Leu Met Lys Ile Phe Ser Leu 
            180                 185                 190         


Asn Leu Gly Leu Asp Glu Asp Tyr Leu Glu Asn Ala Phe Gly Gly Glu 
        195                 200                 205             


Glu Ile Gly Ala Thr Leu Arg Val Asn Phe Tyr Pro Lys Cys Pro Gln 
    210                 215                 220                 


Pro Asp Leu Thr Leu Gly Ile Ser Pro His Ser Asp Pro Gly Gly Ile 
225                 230                 235                 240 


Thr Ile Leu Leu Pro Asp Asp His Val Ser Gly Leu Gln Val Arg Arg 
                245                 250                 255     


Asp Asp Ala Trp Val Thr Val Lys Pro Ile Pro Asn Ala Phe Ile Val 
            260                 265                 270         


Asn Leu Ala Asp Gln Leu Gln Val Ile Ser Asn Ala Lys Tyr Lys Ser 
        275                 280                 285             


Ile Glu His Arg Val Ile Val Asn Ser Asn Glu Glu Arg Val Ser Leu 
    290                 295                 300                 


Ala Phe Phe Tyr Asn Pro Arg Gly Asp Ile Pro Ile Lys Pro Ala Glu 
305                 310                 315                 320 


Gln Leu Ile Ala Asp Thr Glu Ser Ala Leu Tyr Glu Pro Met Thr Phe 
                325                 330                 335     


Asn Glu Tyr Arg Thr Phe Ile Arg Leu Asn Gly Leu His Gly Lys Ser 
            340                 345                 350         


Gln Val Glu Ser Leu Lys Ser Pro Arg 
        355                 360     


<210>  358
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  358

Met Glu Asn Pro Ser His Ser Gln Thr Thr Pro Leu Ser Tyr Pro Pro 
1               5                   10                  15      


Cys Phe Arg Pro Asn Ser Pro Gln Leu Ser His Gln Thr Asn Thr Pro 
            20                  25                  30          


His Asp Gln Thr Leu Glu Leu Glu Asn Asp Pro Leu Pro Val Ile Asp 
        35                  40                  45              


Phe Gln His Ile Asp Leu Met Lys Leu Glu Glu Ala Cys Met Asp Trp 
    50                  55                  60                  


Gly Ile Phe Arg Leu Val Asn His Asp Ile Pro Leu Thr Leu Met Ser 
65                  70                  75                  80  


Lys Val His Glu His Val Tyr Asn Val Phe Asp Ile Gly Phe Glu Thr 
                85                  90                  95      


Lys Gln Lys Met Phe Glu Ser Ile Pro Ala Ser Val Leu Ser Tyr Phe 
            100                 105                 110         


Trp Gly Thr Pro Ala Leu Thr Pro Ser Gly Val Ala Leu Tyr Lys Asp 
        115                 120                 125             


Gly Asp Lys Gln Ser Asp Gln Gly Thr Ile Ser Tyr Asn Trp Val Glu 
    130                 135                 140                 


Gly Leu Asn Tyr Pro Leu Ser Gln Gly Ser Leu Asp Phe Cys Leu Asp 
145                 150                 155                 160 


Gln Tyr Pro Met Val Arg Asp Met Arg Thr Leu Leu Glu Glu Tyr Gly 
                165                 170                 175     


Val His Gln Glu Arg Ile Ala Lys Ser Ile Phe Gly Ala Met Ser Gln 
            180                 185                 190         


Lys Leu Ser Ile Cys Glu Glu Asn Glu Gly Tyr Leu Ser Pro Ser Thr 
        195                 200                 205             


Gly Ile Leu Arg Val Tyr Arg Tyr Pro Ile Ser Phe Phe Asp Lys Ser 
    210                 215                 220                 


Thr Lys Val Trp Gly Met Glu Ala His Thr Asp Ser Ser Val Val Thr 
225                 230                 235                 240 


Ile Leu Asn Gln Tyr Glu Val Ala Gly Leu Gln Val Leu Ser Pro Lys 
                245                 250                 255     


Asp Glu Trp Ile Asp Ala Lys Pro Ile Pro Asn Thr Leu Val Val His 
            260                 265                 270         


Leu Gly Asp Met Met Gln Ala Ile Ser Asp Asp Lys Tyr Lys Ser Val 
        275                 280                 285             


Lys His Arg Val Met Val Asn Arg Glu Arg Glu Arg Ile Ser Met Gly 
    290                 295                 300                 


Tyr Phe Val Phe Pro Asp Asn Asp Cys Val Ile Arg Ser Ser Asn Tyr 
305                 310                 315                 320 


Lys Pro Phe Thr Tyr Leu Asp Phe Arg Ser Gln Val Gln Asp Asp Ile 
                325                 330                 335     


Lys Asn Leu Gly Val Lys Val Gly Leu Ser Arg Phe Lys Leu Asn Lys 
            340                 345                 350         


Asp Phe Tyr Ile 
        355     


<210>  359
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  359

Met Ala Pro Ser Phe Gly Asp Glu Asn Ser Leu Thr Asn Phe Val Val 
1               5                   10                  15      


Lys Glu Gly Asn Gly Val Lys Gly Leu Val Asp Ser Gly Leu Met Glu 
            20                  25                  30          


Val Pro Ser Arg Tyr Ile Gln Pro Pro His Asn Arg Ile Ser Lys Gln 
        35                  40                  45              


His Thr Thr Ala Ser Ile Asp Gln Ser Met Thr Ile Asp Leu Ser Glu 
    50                  55                  60                  


Leu Asp Gly Pro Asn Asp Asp Gln Val Val Lys Ser Ile Ala His Ala 
65                  70                  75                  80  


Ala Glu Thr Leu Gly Phe Phe Gln Val Val Asn His Gly Val Pro Leu 
                85                  90                  95      


Glu Leu Leu Asp Ser Leu Lys Val Ala Ala His Gln Phe Phe Asn Gln 
            100                 105                 110         


Pro Val Glu Lys Lys Ala Val Tyr Leu Lys Gly Val Ser Pro Ser Pro 
        115                 120                 125             


Met Val Lys Tyr Gly Thr Ser Phe Asn Pro Asp Lys Glu Lys Ala Leu 
    130                 135                 140                 


Glu Trp Lys Asp Tyr Val Ser Met Ile Tyr Thr Asn Asp Asp Asp Ala 
145                 150                 155                 160 


His Met Phe Trp Pro Asn Glu Cys Lys Glu Val Ala Leu Glu Phe Ile 
                165                 170                 175     


Lys Thr Thr Asn Gln Met Val Gln Arg Leu Phe Gln Ala Leu Ile Thr 
            180                 185                 190         


Ser Leu Gly Val Lys Leu Asp Asp Ser Arg Phe Asp Glu Leu Ile Gly 
        195                 200                 205             


Phe Arg Met Val Asn Met Asn Tyr Tyr Pro Ala Cys Pro Asn Pro Asp 
    210                 215                 220                 


Leu Thr Val Gly Val Gly Lys His Ser Asp Met Gly Thr Leu Thr Val 
225                 230                 235                 240 


Leu Leu Gln Asp Gly Ile Gly Gly Leu Tyr Val Lys Lys Gly Asp Asp 
                245                 250                 255     


Ser Ser Pro Gly Ser Glu Glu Trp Ile Gly Ile Pro Pro Ala His Gly 
            260                 265                 270         


Ala Leu Val Ile Asn Val Gly Asp Thr Leu Gln Ile Leu Ser Asn Gly 
        275                 280                 285             


Arg Tyr Lys Ser Ala Glu His Arg Val Arg Thr Thr Ser Val Glu Ser 
    290                 295                 300                 


Arg Val Ser Ile Pro Ile Phe Thr Ala Pro Leu Pro Lys Thr Lys Ile 
305                 310                 315                 320 


Gly Pro Leu Ala Glu Leu Val Ala Arg Asp Gly Ile Ala Arg Ser Arg 
                325                 330                 335     


Glu Leu Leu Phe Glu Glu Tyr Met Asn Asn Phe Phe Ala Asn Thr His 
            340                 345                 350         


Asp Gly Lys Lys Ser Leu Asp Phe Ala Ser Thr Thr 
        355                 360                 


<210>  360
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  360

Met Lys Glu Asp Thr Asp Ser Lys Lys Trp Phe Asn Val Glu Tyr Val 
1               5                   10                  15      


Pro Lys Asp Tyr Ile Phe Pro Lys Glu Glu Arg Pro Glu Asn Leu Asp 
            20                  25                  30          


Thr Pro Val Cys Asp Ser Ile Pro Val Ile Asp Leu Ser Lys Ser Lys 
        35                  40                  45              


Ser Val Glu Thr Ile Leu Met Ala Ser Arg Glu Leu Gly Phe Phe Gln 
    50                  55                  60                  


Val Ile Asn His Gly Ile Pro Glu Lys Ile Val Thr Asp Ala Met Ser 
65                  70                  75                  80  


Val Leu Lys Glu Phe Phe Asp Met Pro Ser Lys Asp Arg Thr Gly Ile 
                85                  90                  95      


Val Pro His Lys Lys Gly Tyr Ile Tyr Thr Asn Ser Thr Asp Tyr Ala 
            100                 105                 110         


Lys Asp Gly Val His Leu Trp Arg Glu Asn Ile Lys His Pro Cys His 
        115                 120                 125             


Pro Leu Glu Glu Cys Ile His Leu Trp Pro Glu Lys Pro Thr Arg Tyr 
    130                 135                 140                 


Gln Glu Val Ile Gly Ala Tyr Leu Lys Glu Ile Gln Lys Leu Ser Ser 
145                 150                 155                 160 


Arg Ile Leu Glu Met Ile Cys Glu Gly Leu Gly Leu Glu Pro Gly Tyr 
                165                 170                 175     


Leu Glu Asp Thr Ser Glu Val Ser Leu Leu Ser Ser Asn Leu Tyr Pro 
            180                 185                 190         


Pro Cys Pro Asp Pro Ser Leu Thr Leu Gly Ile Leu Pro His Gln Asp 
        195                 200                 205             


Pro Ser Leu Ile Thr Leu Leu Tyr Gln Gly Asn Ser Thr Gly Leu Gln 
    210                 215                 220                 


Val Met Lys Asp Ser Gln Trp Ile Asn Val Gly Asp Phe Pro Asn Ala 
225                 230                 235                 240 


Phe Val Val Asn Ile Gly Asn Gln Leu Glu Ile Ile Ser Asn Gly Lys 
                245                 250                 255     


Leu Arg Ser Ile Lys His Arg Val Val Thr Ser Thr His Glu Thr Arg 
            260                 265                 270         


Ile Ser Ile Ala Thr Phe Val Asn Pro Ser Pro Asp Cys Ile Ile Glu 
        275                 280                 285             


Pro Ala Lys Val Leu Val Asn Glu Leu Glu Pro Ser Arg Tyr Thr Ala 
    290                 295                 300                 


Ser Gln Tyr Lys Glu Tyr Val Lys Ser Ser Lys Ala Tyr Gly Asp Tyr 
305                 310                 315                 320 


Thr Val Ala Ile Gln Asn Ala Leu His Ser 
                325                 330 


<210>  361
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  361

Met Gly Val Pro Gln His Phe Leu Tyr Ile Cys Thr Ile Leu Ile Ser 
1               5                   10                  15      


Pro Leu Leu Phe Thr Tyr Asn His Ile Ser Ser Asn Asn His Thr Pro 
            20                  25                  30          


Lys Thr Leu Glu Asn Ser Cys Gly Val Met Val Ser Thr Leu Gln Ser 
        35                  40                  45              


Trp Pro Glu Pro Val Val Arg Val Gln Ser Leu Ser Asp Ser Gly Ile 
    50                  55                  60                  


Asn Ala Ile Pro Asp Cys Tyr Val Lys Ala Ile Tyr Asp Arg Pro Ser 
65                  70                  75                  80  


Ser Leu Asp Asn Ile Ser Ser Ile Glu Ala Asn Asp Ile Pro Ile Ile 
                85                  90                  95      


Asn Leu Ala Asn Leu Tyr Ala Asn Asp Pro Asn Leu Arg Lys Thr Thr 
            100                 105                 110         


Met Asp Leu Ile Ser Asp Ala Cys Arg Glu Trp Gly Met Phe Gln Val 
        115                 120                 125             


Ile Asn His Gly Val Ser His His Leu Met Ala Ala Thr Lys Arg Val 
    130                 135                 140                 


Trp Arg Glu Phe Phe His Leu Pro Leu Asp Met Lys Gln Thr Tyr Ala 
145                 150                 155                 160 


Asn Ser Pro Ala Thr Tyr Glu Gly Tyr Gly Ser Arg Val Gly Val Glu 
                165                 170                 175     


Lys Gly Ala Lys Leu Asp Trp Ser Asp Tyr Phe Phe Leu Gln Phe Leu 
            180                 185                 190         


Pro Ala Ser Met Arg Asp Glu Ser Lys Trp Pro Thr Gln Pro Ser Ser 
        195                 200                 205             


Cys Arg Glu Leu Val Ala Glu Tyr Asn Glu Glu Val Leu Lys Leu Cys 
    210                 215                 220                 


Ser Arg Leu Met Lys Ile Phe Ser Leu Asn Leu Gly Leu Asp Glu Asp 
225                 230                 235                 240 


Tyr Leu Glu Asn Ala Phe Gly Gly Glu Glu Ile Gly Ala Thr Leu Arg 
                245                 250                 255     


Val Asn Phe Tyr Pro Lys Cys Pro Gln Pro Asp Leu Thr Leu Gly Ile 
            260                 265                 270         


Ser Pro His Ser Asp Pro Gly Gly Ile Thr Ile Leu Leu Pro Asp Asp 
        275                 280                 285             


His Val Ser Gly Leu Gln Val Arg Arg Asp Asp Ala Trp Val Thr Val 
    290                 295                 300                 


Lys Pro Ile Pro Asn Ala Phe Ile Val Asn Leu Ala Asp Gln Leu Gln 
305                 310                 315                 320 


Val Ile Ser Asn Ala Lys Tyr Lys Ser Ile Glu His Arg Val Ile Val 
                325                 330                 335     


Asn Ser Asn Glu Glu Arg Val Ser Leu Ala Phe Phe Tyr Asn Pro Arg 
            340                 345                 350         


Gly Asp Ile Pro Ile Lys Pro Ala Glu Gln Leu Ile Thr Asp Thr Glu 
        355                 360                 365             


Ser Ala Leu Tyr Gln Pro Met Thr Phe Asn Glu Tyr Arg Thr Phe Ile 
    370                 375                 380                 


Arg Leu Asn Gly Leu His Gly Lys Ser Gln Val Glu Ser Leu Lys Ser 
385                 390                 395                 400 


Pro Arg 
        


<210>  362
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  362

Met Glu Pro Lys Gly Thr Asp Leu Gly Ser Ser Leu Leu Val Pro Ser 
1               5                   10                  15      


Val Gln Glu Leu Val Lys Glu Pro Ile Thr Lys Val Pro Ser Arg Tyr 
            20                  25                  30          


Val Arg Leu Asp Gln Asp Pro Pro Ile Ile Ser Gln Pro Pro Ser Ser 
        35                  40                  45              


Leu Pro Glu Val Pro Val Ile Asp Met Ala Arg Leu Ser Ser Glu Asn 
    50                  55                  60                  


Ser Ala Asp His Glu Leu Glu Lys Leu His Leu Ala Cys Lys Asp Trp 
65                  70                  75                  80  


Gly Phe Phe Gln Ile Ile Asn His Gly Val Gly Val Ser Leu Leu Asp 
                85                  90                  95      


Lys Val Lys Glu Glu Thr Gln Glu Phe Phe Asn Leu Pro Met Glu Glu 
            100                 105                 110         


Lys Lys Lys Phe Trp Gln Thr Thr Asp Asp Ile Glu Gly Phe Gly Gln 
        115                 120                 125             


Ala Phe Val Val Ser Glu Glu Gln Lys Leu Asp Trp Ala Asp Ile Phe 
    130                 135                 140                 


Tyr Leu Ile Thr Leu Pro His Gly Ile Arg Lys Pro His Leu Phe Pro 
145                 150                 155                 160 


Asn Leu Pro Met Pro Phe Arg Asp Thr Leu Glu Ala Tyr Ser Arg Glu 
                165                 170                 175     


Leu Lys Asn Ala Ala Ile Lys Thr Leu Leu Tyr Ile Ala Lys Ala Leu 
            180                 185                 190         


Lys Met Glu Ser Lys Asp Met Ile Val Leu Phe Glu Glu Gly Met Gln 
        195                 200                 205             


Ser Met Arg Met Asn Tyr Tyr Pro Pro Cys Pro Gln Pro Glu Gln Val 
    210                 215                 220                 


Ile Gly Leu Thr Pro His Ser Asp Ala Val Gly Ile Thr Phe Leu Leu 
225                 230                 235                 240 


Gln Leu Asn Glu Val Pro Gly Leu Gln Ile Arg Lys Asp Glu Ile Trp 
                245                 250                 255     


Ile Pro Ile Lys Pro Leu Pro Asn Ala Phe Ile Val Asn Ile Gly Glu 
            260                 265                 270         


Ile Leu Glu Ile Val Thr Asn Gly Gln Tyr Lys Ser Val Glu His Arg 
        275                 280                 285             


Ala Ile Val Asn Ser Glu Lys Glu Arg Leu Ser Ile Ala Thr Phe Leu 
    290                 295                 300                 


Asn Pro Lys Leu Asp Gly Asp Leu Gly Pro Ala Pro Ser Leu Ile Thr 
305                 310                 315                 320 


Ser Lys Thr Pro Pro Lys Phe Lys Arg Val Ala Val Ala Asp Phe Phe 
                325                 330                 335     


Lys Asn Leu Phe Ser Arg Glu Leu Asn Arg Lys Thr Asn Leu Glu Gln 
            340                 345                 350         


Tyr Tyr Val 
        355 


<210>  363
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  363

Met Pro Thr Pro Ala Ile Pro Thr Val Asp Leu Ser Pro Phe Phe Thr 
1               5                   10                  15      


Ala Gly Asp Asp Ser Gly Arg Lys Lys Ala Lys Asp Ile Ile Ala Glu 
            20                  25                  30          


Ala Cys Thr Asp Tyr Gly Phe Phe Gln Ile Val Asn His Gly Val Pro 
        35                  40                  45              


Leu Glu Val Met Asn Gln Ala Met Glu Leu Ser Lys Thr Phe Phe Ser 
    50                  55                  60                  


Tyr Ser Asp Glu Val Lys Arg Glu Ser Ser Ser Gly Pro Asp Ala Pro 
65                  70                  75                  80  


Leu Pro Ala Gly Tyr Asn Lys Gln Pro Asp His Ser Pro Asp Lys Asn 
                85                  90                  95      


Glu Tyr Leu Leu Met Phe Pro Pro Glu Ser Pro Phe Asn Ile Leu Pro 
            100                 105                 110         


Asp Asn Pro Pro Glu Phe Arg Lys Thr Leu Glu Glu Met Phe Lys Tyr 
        115                 120                 125             


Phe Val Lys Thr Gly Gln Ile Leu Glu Asp Ile Ile Ser Glu Cys Leu 
    130                 135                 140                 


Asp Leu Pro Pro Asn Phe Leu Lys Glu Tyr Asn Asn Asp Arg Ser Trp 
145                 150                 155                 160 


Asp Phe Met Val Thr Met Arg Tyr Lys Pro Ala Thr Glu Thr Glu Asn 
                165                 170                 175     


Asn Gly Ile Thr Glu His Glu Asp Gly Asn Leu Ile Thr Met Val Leu 
            180                 185                 190         


Gln Glu Asp Ile Gly Gly Leu Glu Val Ser Lys Asn Gly Glu Trp Ile 
        195                 200                 205             


Pro Val Ile Pro Ser Lys Gly Thr Leu Val Val Asn Ile Ser Asp Val 
    210                 215                 220                 


Ile Gln Val Leu Ser Asn Lys Lys Phe Lys Ser Ala Thr His Arg Val 
225                 230                 235                 240 


Val Arg Pro Lys Glu Arg Ser Arg His Ser Tyr Val Phe Phe Tyr Ser 
                245                 250                 255     


Leu Gln Gly Asp Lys Trp Val Glu Pro Leu Pro Gln Phe Thr Gln Glu 
            260                 265                 270         


Ile Gly Ala Lys Pro Lys Tyr Lys Gly Phe Tyr Tyr Lys Asp Tyr Gln 
        275                 280                 285             


Ala Leu Arg Met Arg Asn Lys Thr His Pro Pro Ser Lys Pro Glu Asp 
    290                 295                 300                 


Ile Ala Arg Leu Thr Met Tyr Glu Ile 
305                 310             


<210>  364
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  364

Met Gly Phe Leu Ala Gln Pro Lys Ile Pro Val Ile Asn Met Val Asp 
1               5                   10                  15      


Leu Lys Gln Asn Thr Thr Phe Gly Val Ser Ala Cys Asp Glu Val Arg 
            20                  25                  30          


His Ala Leu Glu Glu Tyr Gly Cys Phe Leu Val Asp Cys Asn Gly Ile 
        35                  40                  45              


Thr Glu Gly Phe Ser Ser Glu Val Leu Asp Ala Leu Gln Asn Leu Phe 
    50                  55                  60                  


Asp Leu Pro Ile Glu Thr Lys Val Lys Asn Ile Ser Asp Lys Ala Tyr 
65                  70                  75                  80  


His Gly Tyr Val Gly Gln Ile Pro Phe Leu Pro Leu Leu Glu Ser Met 
                85                  90                  95      


Gly Ile Glu Asn Ala Thr Ser Val His Gly Val Asn Ser Phe Thr Thr 
            100                 105                 110         


Thr Met Trp Pro Ser Gly Asn Asp Asn Phe Cys Asn Met Ile His Ser 
        115                 120                 125             


Tyr Ala Arg Phe Val Ser Glu Ile Glu Glu Thr Val Arg Lys Met Val 
    130                 135                 140                 


Phe Arg Ser Phe Gly Val Glu Lys Tyr His Gln Ser Tyr Asn Asp Ser 
145                 150                 155                 160 


Val Thr Tyr Leu Leu Arg Val Met Lys Tyr Arg Pro Pro Ser Ala Asn 
                165                 170                 175     


Glu Thr Lys Leu Gly Ser Ile Ser His Thr Asp Lys Ser Phe Ile Ser 
            180                 185                 190         


Ile Leu Thr Gln Asn Gln Val Lys Gly Leu Glu Val Lys Thr Lys Asp 
        195                 200                 205             


Asn Lys Trp Ile Pro Val Glu Tyr Pro Pro Cys Ser Phe Leu Val Met 
    210                 215                 220                 


Ala Gly Asp Ala Phe Lys Ala Trp Ser Asn Asp Arg Val His Ser Pro 
225                 230                 235                 240 


Tyr His Arg Val Val Met Glu Gly Gly Glu Tyr Arg Tyr Ser Ile Gly 
                245                 250                 255     


Val Phe Thr Tyr His Lys Gly Ile Val Thr Val Pro Glu Glu Leu Val 
            260                 265                 270         


Asp Asn Asp His Leu Arg Lys Phe Lys Ser Phe Asp His Phe Gly Tyr 
        275                 280                 285             


Leu Asp Phe Tyr Asp Lys Asp Ser Leu Phe Glu Gln Glu Phe Ser His 
    290                 295                 300                 


Ile Lys Ser Tyr Cys Gly Val 
305                 310     


<210>  365
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  365

Met Ser Thr Asp Phe Gln Ser Ile Pro Leu Ile Asp Ile Gly Pro Leu 
1               5                   10                  15      


Val Ala Lys Cys Asp Asp Leu Asn Ala Met Glu Asp Lys Asp Val Ala 
            20                  25                  30          


Glu Val Val Arg Leu Leu Asp Gln Ala Cys Arg Glu Ala Gly Phe Phe 
        35                  40                  45              


Tyr Val Lys Gly His Gly Ile Pro Glu Ser Leu Ile Lys Glu Val Arg 
    50                  55                  60                  


Asp Met Thr His Glu Phe Phe Asn Leu Pro Tyr Glu Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Lys Leu Ser Asp Ala Thr Gly Tyr Arg Gly Tyr Gln Arg Ile Gly 
                85                  90                  95      


Val Asn Ile Thr Lys Gly Val Pro Asp Met His Glu Ala Ile Asp Cys 
            100                 105                 110         


Tyr Lys Glu Leu Ser Lys Gly Met Tyr Gly Asp Leu Ser Asp Pro Leu 
        115                 120                 125             


Val Gly Asn Asn Arg Trp Pro Met Asp Pro Pro Lys Phe Lys Lys Leu 
    130                 135                 140                 


Met Glu Glu Tyr Leu Thr Leu Cys Thr Glu Leu Ser Arg Lys Ile Met 
145                 150                 155                 160 


Arg Gly Ile Ala Leu Ala Leu Gly Gly Ser Val Asp Glu Phe Glu Gly 
                165                 170                 175     


Lys Ile Ala Gly Asp Pro Phe Trp Val Leu Arg Ile Ile Gly Tyr Pro 
            180                 185                 190         


Gly Ala Leu Thr Thr Ser Glu Glu Gly Leu Pro Lys Asn Asp Val Gly 
        195                 200                 205             


Cys Gly Ala His Thr Asp Tyr Gly Leu Leu Thr Leu Val Asn Gln Asp 
    210                 215                 220                 


Asp Asp Lys Thr Ala Leu Gln Val Arg Asn Leu Ser Gly Glu Trp Ile 
225                 230                 235                 240 


Ser Ala Val Pro Ile Pro Gly Thr Phe Val Cys Asn Ile Gly Asp Met 
                245                 250                 255     


Leu Lys Ile Leu Thr Asn Gly Leu Tyr Glu Ser Thr Leu His Arg Val 
            260                 265                 270         


Ile Asn Asn Ser Pro Lys Tyr Arg Val Cys Val Ala Tyr Phe Tyr Glu 
        275                 280                 285             


Thr Asn Phe Asn Ala Thr Ile Arg Pro Leu Asp Met Cys Ile Lys Lys 
    290                 295                 300                 


Ser Gly Gly Asn Lys Lys Phe Glu Gly Ala Val Tyr Gly Glu His Leu 
305                 310                 315                 320 


Val Gly Lys Val Met Thr Asn Phe Thr Phe 
                325                 330 


<210>  366
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  366

Met Ala Leu Asp Gly Lys Ser Leu Gly Gly Ser Leu Ser Val Pro Cys 
1               5                   10                  15      


Val Gln Glu Leu Ala Lys Glu Ser Leu Val Glu Ala Pro Pro Arg Tyr 
            20                  25                  30          


Val Arg Pro Asp Gln Asp Pro Ile Phe Ala Ser Val Leu Ser Ala Thr 
        35                  40                  45              


Gln Thr Glu Val Pro Val Ile Asp Met Gln Arg Leu Leu Ser Glu Glu 
    50                  55                  60                  


Ser Ala Asn Ser Glu Leu Glu Arg Leu His Ile Ala Cys Lys Asp Trp 
65                  70                  75                  80  


Gly Phe Phe Gln Met Ile Asn His Gly Val Ser Cys Ser Leu Leu Glu 
                85                  90                  95      


Lys Val Lys Glu Glu Ile Gln Glu Phe Phe Asn Leu Pro Met Ala Glu 
            100                 105                 110         


Lys Asn Lys Phe Leu Gln Glu Ala Gly Asp Leu Glu Gly Phe Gly Gln 
        115                 120                 125             


Ala Tyr Val Phe Ser Glu Glu Gln Lys Leu Asp Trp Ala Asp Met Phe 
    130                 135                 140                 


Tyr Val Val Thr Leu Pro Tyr His Leu Arg Lys Pro His Leu Leu Pro 
145                 150                 155                 160 


Lys Leu Pro Leu Pro Leu Arg Asp Thr Ile Glu Ala Tyr Ser Arg Glu 
                165                 170                 175     


Leu Lys Asp Ile Ser Met Lys Thr Leu Phe Leu Met Ala Lys Ala Leu 
            180                 185                 190         


Asn Met Glu Val Glu Asp Met Asn Val Leu Phe Asp Glu Gly Met Gln 
        195                 200                 205             


Ser Met Arg Met Asn Tyr Tyr Pro Pro Cys Pro Glu Pro Glu Lys Val 
    210                 215                 220                 


Ile Gly Leu Ser Pro His Ser Asp Pro Leu Gly Ile Thr Phe Leu Leu 
225                 230                 235                 240 


Gln Ile Asn Asp Val Glu Gly Leu Gln Ile Arg Lys Asp Gly Ile Trp 
                245                 250                 255     


Met Pro Val Lys Pro Leu Pro Asn Ala Phe Ile Val Asn Ile Gly Asp 
            260                 265                 270         


Val Leu Glu Ile Val Thr Asn Gly Gln Tyr Lys Ser Ile Glu His Arg 
        275                 280                 285             


Ala Val Val Asn Ser Glu Lys Ala Arg Leu Ser Ile Gly Thr Phe Leu 
    290                 295                 300                 


Thr Pro Lys Leu Asp Gly Asp Phe Gly Pro Ala Pro Ser Leu Ile Ser 
305                 310                 315                 320 


Pro Glu Thr Pro Pro Arg Phe Ala Arg Val Thr Val Val Asp Phe Leu 
                325                 330                 335     


Arg Asn Leu Phe Ser Lys Glu Leu Asp Arg Lys Thr Asn Val Asp Gln 
            340                 345                 350         


Tyr Tyr Ile 
        355 


<210>  367
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  367

Met Ser Thr Glu Asn His Lys Glu Glu Ala Ile Asn Leu Gly Arg Ser 
1               5                   10                  15      


Leu Ile Ala Pro Ser Val Gln Glu Leu Ala Lys Gln Ser Ile Lys His 
            20                  25                  30          


Ile Pro Pro Glu Tyr Pro His Gln His Asp Gln Asp Gln Asp Gln Met 
        35                  40                  45              


Leu Leu Ser Cys Asp Asp Val Ser Val Pro Val Ile Asp Leu Arg Ser 
    50                  55                  60                  


Leu Phe Ala Asn Thr Ser Glu Ser Tyr Ser Ser Glu Phe Asn Lys Leu 
65                  70                  75                  80  


His Thr Ala Cys Lys Glu Trp Gly Phe Phe Gln Val Ile Asn His Gly 
                85                  90                  95      


Ile Asn Glu Ser Leu Leu Ala Asp Phe Lys Arg Asp Ala Leu Asn Phe 
            100                 105                 110         


Phe Asn Leu Pro Met Glu Glu Lys Lys Lys Leu Trp Gln Lys Glu Asp 
        115                 120                 125             


Asn Asn Glu Gly Phe Gly Gln Leu Phe Val Val Ser Lys Glu Gln Lys 
    130                 135                 140                 


Leu Asp Trp Cys Asp Met Phe Tyr Ile Thr Ile Leu Pro His Asp Leu 
145                 150                 155                 160 


Trp Lys Ser Gln Leu Phe Gln Lys Leu Pro Leu Ile Leu Arg Gln Thr 
                165                 170                 175     


Leu Glu Ala Tyr Cys Val Glu Met Lys Lys Leu Ala Met Ala Ile Leu 
            180                 185                 190         


Ser Gln Met Gly Lys Ala Leu Glu Met Asp Glu Asp Glu Ile Thr Gly 
        195                 200                 205             


Leu Phe His Asp Gly Tyr Gln Ser Met Arg Met Asn His Tyr Pro Pro 
    210                 215                 220                 


Cys Pro Gln Pro Asn Met Ala Met Gly Ile Ser Pro His Ser Asp Ala 
225                 230                 235                 240 


Asn Ala Leu Thr Ile Leu Tyr Gln Leu Asn Thr Thr Asp Gly Leu Glu 
                245                 250                 255     


Val Arg Lys Asp Gly Lys Trp Val Thr Ile Lys Pro Leu Pro Asn Ala 
            260                 265                 270         


Leu Val Val Asn Ile Gly Asp Ile Met Glu Ile Val Ser Asn Gly Glu 
        275                 280                 285             


Tyr Lys Ser Ile Lys His Arg Gly Ile Val Lys Ala His Ser Glu Arg 
    290                 295                 300                 


Leu Pro Ala Lys Ser Leu Val Ala Lys His Lys Val Ala Asn Phe Lys 
305                 310                 315                 320 


Gln Ile Pro Leu Glu Glu Phe Phe Lys Glu Tyr Phe Ala Arg Lys Leu 
                325                 330                 335     


Asp Gly Lys Ser His Leu Glu Ile Met Lys Leu Glu Gly 
            340                 345                 


<210>  368
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  368

Met Thr Cys Pro Ser Asp Trp Pro Glu Pro Ile Val Arg Val Gln Thr 
1               5                   10                  15      


Leu Ser Glu Thr Glu Ser Gln Leu Ile Pro Thr Arg Tyr Val Lys Pro 
            20                  25                  30          


Leu Leu Glu Arg Pro Ser Phe Asn Lys Gly Asp Gln Gly Asn Ser Asn 
        35                  40                  45              


Ile Pro Leu Ile Asp Leu Phe Asp Leu Thr Asn Gly Asp Ala Arg Ala 
    50                  55                  60                  


Lys Lys Ala Ile Met Asp Lys Ile Ser Ile Ala Cys Arg Glu Trp Gly 
65                  70                  75                  80  


Phe Phe Gln Val Val Asn His Gly Met Ser Ser His Leu Val Asp Glu 
                85                  90                  95      


Ala Arg Glu Val Trp Arg Glu Phe Phe His Gln Pro Met Glu Leu Lys 
            100                 105                 110         


Gln Glu Tyr Ala Asn Thr Pro Lys Thr Tyr Glu Gly Tyr Gly Ser Arg 
        115                 120                 125             


Leu Gly Ile Gln Lys Gly Ala Ile Leu Asp Trp Ser Asp Tyr Tyr Phe 
    130                 135                 140                 


Leu Asn Tyr Leu Pro Ser Thr Leu Lys Asp His Asn Lys Trp Pro Ser 
145                 150                 155                 160 


Gln Pro Pro Leu Leu Arg Asn Val Thr Glu Glu Tyr Ser Asn Glu Ile 
                165                 170                 175     


Val Arg Leu Gly Lys Val Leu Leu Lys Val Phe Ser Ile Asn Leu Gly 
            180                 185                 190         


Leu Gln Glu Asp Tyr Leu Gln Asp Ala Phe Gly Gly Asp Asp Ile Gly 
        195                 200                 205             


Ala Cys Leu Arg Val Asn Phe Tyr Pro Lys Cys Pro Gln Pro Asp Leu 
    210                 215                 220                 


Thr Leu Gly Leu Ser Ser His Ser Asp Pro Gly Gly Met Thr Phe Leu 
225                 230                 235                 240 


Leu Pro Asp Glu His Val Ser Gly Leu Gln Val Arg Lys Gly Gly Glu 
                245                 250                 255     


Trp Ile Thr Val Lys Pro Ala Arg His Ala Ile Ile Val Asn Ile Gly 
            260                 265                 270         


Asp Gln Ile Gln Val Leu Thr Asn Ala Ile Tyr Lys Ser Val Glu His 
        275                 280                 285             


Arg Val Val Val Asn Pro Asp Lys Glu Arg Val Ser Leu Ala Tyr Phe 
    290                 295                 300                 


Ile Asn Pro Lys Ser Asp Ile Leu Ile Lys Pro Ala Thr Glu Leu Val 
305                 310                 315                 320 


Thr Ser Asn Ala Pro Ala Leu Tyr Pro Pro Met Thr Phe Asp Glu Tyr 
                325                 330                 335     


Arg Leu Phe Ile Arg Thr Lys Gly Pro Gln Gly Lys Ser Gln Val Glu 
            340                 345                 350         


Ser Leu Lys Ser Ser Arg 
        355             


<210>  369
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  369

Met Val Cys Pro Cys Asp Trp Pro Glu Pro Val Val Arg Val Gln Ser 
1               5                   10                  15      


Leu Ser Glu Ser Gly Lys Pro Val Ile Pro Glu Arg Tyr Ile Lys Pro 
            20                  25                  30          


Pro Thr Asp Arg Pro Ser Phe Asn Ser Ser Pro Pro Asp Ile Asn Ile 
        35                  40                  45              


Pro Ile Ile Asp Leu Ala Gly Leu Thr Asn Asp Asp Ile Thr Val Arg 
    50                  55                  60                  


Glu Ala Thr Leu Arg Glu Ile Ser Glu Ala Cys Arg Glu Trp Gly Phe 
65                  70                  75                  80  


Phe Gln Val Val Asn His Gly Leu Ser Gly Glu Leu Val Asp Gly Val 
                85                  90                  95      


Arg Glu Ile Trp Arg Glu Phe Phe His Glu Ser Met Glu Val Lys Gln 
            100                 105                 110         


Lys Tyr Ala Asn Ser Pro Lys Thr Tyr Glu Gly Tyr Gly Ser Arg Leu 
        115                 120                 125             


Gly Leu Gln Lys Gly Ala Ile Leu Asp Trp Ser Asp Tyr Tyr Phe Leu 
    130                 135                 140                 


His Tyr Leu Pro Ser Asn Leu Lys Asp His Asn Lys Trp Pro Ala Thr 
145                 150                 155                 160 


Pro Ser Ser Leu Arg Glu Thr Val Glu Glu Tyr Ser Lys Glu Ile Val 
                165                 170                 175     


Arg Leu Gly Ser Val Leu Leu Glu Val Phe Ser Ile Asn Leu Gly Leu 
            180                 185                 190         


Gln Lys Asp Tyr Leu Gln Lys Ala Phe Gly Gly Glu Asp Val Gly Ala 
        195                 200                 205             


Cys Leu Arg Val Asn Phe Tyr Pro Lys Cys Pro Gln Pro Asp Leu Thr 
    210                 215                 220                 


Leu Gly Leu Ser Ser His Ser Asp Pro Gly Gly Ile Thr Phe Leu Leu 
225                 230                 235                 240 


Pro Asp Glu Asn Val Ser Gly Leu Gln Val Arg Arg Gly Glu Gln Trp 
                245                 250                 255     


Ile Thr Val Lys Pro Ala Arg His Ala Ile Ile Ala Asn Ile Gly Asp 
            260                 265                 270         


Gln Ile Gln Val Leu Ser Asn Ala Ile Tyr Lys Ser Val Glu His Arg 
        275                 280                 285             


Val Ile Val Asn Pro Asp Lys Glu Arg Val Ser Leu Ala Tyr Phe Phe 
    290                 295                 300                 


Asn Pro Lys Ser Asp Leu Leu Ile His Pro Ala Pro Glu Leu Val Thr 
305                 310                 315                 320 


Pro Glu Thr Pro Pro Leu Tyr Pro Ser Met Thr Phe Asp Glu Tyr Arg 
                325                 330                 335     


Leu Phe Ile Arg Thr Arg Gly Pro Gln Gly Lys Ser Gln Val Glu Ser 
            340                 345                 350         


Leu Lys Ser Pro Arg 
        355         


<210>  370
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  370

Met Val Cys Pro Cys Asp Trp Pro Glu Pro Val Val Arg Val Gln Ser 
1               5                   10                  15      


Leu Ser Glu Ser Gly Lys Pro Phe Ile Pro Glu Arg Tyr Ile Lys Pro 
            20                  25                  30          


Pro Thr Asp Arg Pro Ser Phe Asn Ser Ser Pro Pro Asp Ile Asn Ile 
        35                  40                  45              


Pro Ile Ile Asp Leu Ala Gly Leu Thr Asn Asp Asp Ile Thr Val Arg 
    50                  55                  60                  


Glu Ala Thr Leu Arg Glu Ile Ser Glu Ala Cys Arg Glu Trp Gly Phe 
65                  70                  75                  80  


Phe Gln Val Val Asn His Gly Leu Ser Gly Glu Leu Val Asp Gly Val 
                85                  90                  95      


Arg Glu Ile Trp Arg Glu Phe Phe His Glu Ser Met Glu Val Lys Gln 
            100                 105                 110         


Lys Tyr Ala Asn Ser Pro Lys Thr Tyr Glu Gly Tyr Gly Ser Arg Leu 
        115                 120                 125             


Gly Leu Gln Lys Gly Ala Ile Leu Asp Trp Ser Asp Tyr Tyr Phe Leu 
    130                 135                 140                 


His Tyr Leu Pro Ser Asn Leu Lys Asp His Asn Lys Trp Pro Ala Thr 
145                 150                 155                 160 


Pro Ser Ser Leu Arg Glu Thr Val Glu Glu Tyr Ser Lys Glu Ile Val 
                165                 170                 175     


Arg Leu Gly Ser Val Leu Leu Glu Val Phe Ser Ile Asn Leu Gly Leu 
            180                 185                 190         


Gln Lys Asp Tyr Leu Gln Lys Ala Phe Gly Gly Glu Asp Val Gly Ala 
        195                 200                 205             


Cys Leu Arg Val Asn Phe Tyr Pro Lys Cys Pro Gln Pro Asp Leu Thr 
    210                 215                 220                 


Leu Gly Leu Ser Ser His Ser Asp Pro Gly Gly Ile Thr Phe Leu Leu 
225                 230                 235                 240 


Pro Asp Glu Asn Val Ser Gly Leu Gln Val Arg Arg Gly Glu Gln Trp 
                245                 250                 255     


Ile Thr Val Lys Pro Ala Arg His Ala Ile Ile Ala Asn Ile Gly Asp 
            260                 265                 270         


Gln Ile Gln Val Leu Ser Asn Ala Ile Tyr Lys Ser Val Glu His Arg 
        275                 280                 285             


Val Ile Val Asn Pro Asp Lys Glu Arg Val Ser Leu Ala Tyr Phe Phe 
    290                 295                 300                 


Asn Pro Lys Ser Asp Leu Leu Ile His Pro Ala Pro Glu Leu Val Thr 
305                 310                 315                 320 


Pro Glu Thr Pro Pro Leu Tyr Pro Ser Met Thr Phe Asp Glu Tyr Arg 
                325                 330                 335     


Leu Phe Ile Arg Thr Arg Gly Pro Gln Gly Lys Ser Gln Val Glu Ser 
            340                 345                 350         


Leu Lys Ser Pro Arg 
        355         


<210>  371
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  371

Met Glu Pro Lys Gly Thr Asp Leu Gly Ser Ser Leu Leu Val Pro Ser 
1               5                   10                  15      


Val Gln Glu Leu Val Lys Glu Pro Ile Thr Lys Val Pro Leu Arg Tyr 
            20                  25                  30          


Val Arg Leu Asp Gln Asp Pro Pro Ile Ile Ser Gln Pro Pro Tyr Ser 
        35                  40                  45              


Leu Pro Glu Val Pro Val Ile Asp Met Ala Arg Leu Ser Ser Glu Asn 
    50                  55                  60                  


Ser Ala Asp His Glu Leu Glu Lys Leu His Leu Ala Cys Lys Asp Trp 
65                  70                  75                  80  


Gly Phe Phe Gln Ile Ile Asn His Glu Val Gly Val Ser Leu Leu Asp 
                85                  90                  95      


Lys Val Lys Glu Glu Thr Gln Glu Phe Phe Asn Leu Pro Met Glu Glu 
            100                 105                 110         


Lys Lys Lys Phe Trp Gln Thr Thr Asp Asp Ile Glu Gly Phe Gly Gln 
        115                 120                 125             


Ala Phe Val Val Ser Glu Glu Gln Lys Leu Asp Trp Ala Asp Met Phe 
    130                 135                 140                 


Tyr Leu Val Thr Leu Pro His Gly Ile Arg Lys Pro His Leu Leu Pro 
145                 150                 155                 160 


Asn Leu Pro Met Pro Phe Arg Asp Thr Leu Glu Ala Tyr Ser Arg Glu 
                165                 170                 175     


Leu Lys Asn Thr Ala Ile Lys Thr Leu Leu Tyr Ile Ala Lys Ala Leu 
            180                 185                 190         


Lys Met Glu Ser Lys Asp Met Ile Val Leu Phe Glu Glu Gly Met Gln 
        195                 200                 205             


Gly Met Arg Met Asn Tyr Tyr Pro Pro Cys Pro Gln Pro Glu Gln Val 
    210                 215                 220                 


Ile Gly Leu Thr Pro His Ser Asp Ala Val Gly Ile Thr Phe Leu Leu 
225                 230                 235                 240 


Gln Leu Asn Glu Val Pro Gly Leu Gln Ile Arg Lys Asp Glu Ile Trp 
                245                 250                 255     


Ile Pro Ile Lys Pro Leu Pro Asn Ala Phe Ile Val Asn Ile Gly Glu 
            260                 265                 270         


Ile Leu Glu Ile Val Thr Asn Gly Gln Tyr Lys Ser Val Glu His Arg 
        275                 280                 285             


Ala Ile Val Asn Ser Glu Lys Glu Arg Leu Ser Ile Ala Thr Phe Leu 
    290                 295                 300                 


Ser Pro Lys Leu Asp Gly Asp Leu Gly Pro Ala Pro Ser Leu Ile Thr 
305                 310                 315                 320 


Pro Lys Thr Pro Pro Lys Phe Thr Arg Val Ala Val Ala Asp Phe Phe 
                325                 330                 335     


Lys Asn Leu Phe Ser Arg Glu Leu Asn Arg Lys Thr Asn Leu Glu Gln 
            340                 345                 350         


Tyr Tyr Val 
        355 


<210>  372
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  372

Met Ala Pro Ser Phe Asn Asp Glu Asn Ser Leu Phe Lys Phe Val Val 
1               5                   10                  15      


Lys Asp Gly Asn Gly Val Lys Gly Leu Val Asp Ser Gly Leu Thr Glu 
            20                  25                  30          


Val Pro Gly Gln Tyr Ile Gln Pro Pro Ile His Arg Ile Lys Lys Gln 
        35                  40                  45              


Asn Ala Thr Val Ser Leu Glu Asn Met Thr Phe Asp Leu Ser Glu Leu 
    50                  55                  60                  


Asp Gly Pro Asn His Asp Gln Val Val Lys Ser Ile Ala His Ala Ala 
65                  70                  75                  80  


Glu Thr Leu Gly Phe Phe Gln Val Val Asn His Gly Val Pro Ile Glu 
                85                  90                  95      


Leu Leu Glu Ser Leu Lys Val Ser Ala His Glu Phe Phe Asn Gln Pro 
            100                 105                 110         


Ser Glu Lys Lys Ala Val Tyr Leu Lys Gly Val Ser Pro Ser Pro Met 
        115                 120                 125             


Val Lys Tyr Gly Thr Ser Phe Val Pro Glu Lys Glu Lys Ala Leu Glu 
    130                 135                 140                 


Trp Lys Asp Tyr Ile Ser Met Ile Tyr Thr Asn Asp Ala Asn Ala Leu 
145                 150                 155                 160 


Glu Phe Trp Pro Asn Glu Cys Lys Glu Val Ala Leu Glu Tyr Ile Lys 
                165                 170                 175     


Thr Ser Thr Glu Met Val Lys Arg Leu Leu His Ala Leu Met Gly Asn 
            180                 185                 190         


Leu Gly Ile Lys Leu Asp Asp Ser Arg Leu Asp Ala Leu Met Gly Leu 
        195                 200                 205             


Arg Met Val Asn Met Asn Phe Tyr Pro Thr Cys Pro Ser Pro Asp Leu 
    210                 215                 220                 


Thr Val Gly Val Gly Arg His Ser Asp Met Gly Thr Leu Thr Val Leu 
225                 230                 235                 240 


Leu Gln Asp Gly Ile Gly Gly Leu Tyr Val Lys Lys Gly Glu Asp Pro 
                245                 250                 255     


Ser Ser Gly Lys Glu Asp Trp Ile Glu Ile Pro Pro Val His Gly Ala 
            260                 265                 270         


Leu Val Ile Asn Ile Gly Asp Ala Leu Gln Ile Ile Ser Asn Gly Arg 
        275                 280                 285             


Tyr Lys Ser Ala Glu His Arg Val Arg Thr Thr Ser Val Glu Ser Arg 
    290                 295                 300                 


Val Ser Val Pro Ile Phe Asn Ala Pro Leu Pro Met Val Lys Ile Gly 
305                 310                 315                 320 


Pro Leu Pro Glu Val Val Ala Arg Asp Gly Val Ala Arg Tyr Arg Glu 
                325                 330                 335     


Val Ile Phe Glu Glu Tyr Met Asn Asn Phe Phe Gly Lys Ser His Asp 
            340                 345                 350         


Gly Lys Lys Ser Leu Asp Phe Val Ala Ile 
        355                 360         


<210>  373
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  373

Met Thr Ile Pro Val Val Asp Leu Ala Ser Ile Leu Gly His Ser Asp 
1               5                   10                  15      


Glu Gly Glu Arg Lys Lys Ala Val Asn Glu Phe Gly Glu Ala Cys Ile 
            20                  25                  30          


Gln Phe Gly Ile Leu Arg Ile Ile Asn His Gly Leu Ala Asp Glu His 
        35                  40                  45              


Val Asn His Ser Phe Glu Val Val Gln Gln Phe Phe Asp Arg Pro Ile 
    50                  55                  60                  


Val Glu Lys Leu Asp Ser Lys Pro Val Ser Thr Ile Leu Pro Ala Gly 
65                  70                  75                  80  


Tyr Gly Lys Ile Asp Ser His Phe Gly Ser Ser Glu Trp Leu Met Val 
                85                  90                  95      


Cys Gln Pro Cys Leu Asp Ile Asn Met Phe Pro Ser Asp Gln Pro Glu 
            100                 105                 110         


Val Ser Glu Thr Leu Glu Lys Met Tyr Gln Asn Phe Gln Lys Leu Gly 
        115                 120                 125             


Ala Ile Val Glu Asn Met Met Asn Glu Tyr Leu Asp Leu Pro Leu Asn 
    130                 135                 140                 


Phe Leu Asn Gln Phe Asn Asp Asp Arg Ser Asn Asp Ile Leu Met Cys 
145                 150                 155                 160 


Trp Arg Tyr Pro Pro Ile Ala Glu Asp Lys Pro Asn Thr Ile Gly Arg 
                165                 170                 175     


Glu Glu His Gln Asp Thr Asn Cys Phe Thr Phe Leu Leu Gln Asp Asp 
            180                 185                 190         


Thr Gly Gly Leu Glu Tyr Glu Lys Asp Gly Ser Trp Met Pro Val Asn 
        195                 200                 205             


Pro Met Lys Gly Ser Leu Val Val Asn Val Gly Ser Thr Ile Gln Ala 
    210                 215                 220                 


Leu Thr Asn Lys Lys Leu Met Ala Ala Arg His Arg Val Trp Lys Pro 
225                 230                 235                 240 


Arg Gly Arg Asn Arg His Ser Phe Ala Phe Phe Tyr Asn Ile Gly Gly 
                245                 250                 255     


Glu Lys Trp Ile Glu Pro Leu Pro Lys Phe Ala Glu Glu Ile Gly Glu 
            260                 265                 270         


Ala Pro Lys Tyr Arg Gly Phe Phe Tyr Lys Glu Leu Leu Gln Ala Arg 
        275                 280                 285             


Leu Lys Lys Glu Lys Asn Pro Leu Thr Leu Leu Asp Glu Val Ile Asp 
    290                 295                 300                 


Leu Asp His Phe Ala Thr Arg Asn 
305                 310         


<210>  374
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  374

Met Ala Pro Ser Phe Asn Asp Glu Asn Ser Leu Phe Asp Phe Val Val 
1               5                   10                  15      


Lys Glu Gly Asn Gly Val Lys Gly Leu Val Asp Ser Gly Leu Thr Glu 
            20                  25                  30          


Val Pro Ser Arg Tyr Ile Gln Pro Pro His Asn Arg Ile Ser Lys Gln 
        35                  40                  45              


His Ala Thr Thr Ser Ile Asp Gln Ser Met Thr Ile Asp Leu Ser Glu 
    50                  55                  60                  


Leu Asp Gly Pro Asn His Asp Gln Val Val Lys Ser Ile Ala His Ala 
65                  70                  75                  80  


Ala Glu Thr Leu Gly Phe Phe Gln Val Val Asn His Gly Val Pro Leu 
                85                  90                  95      


Lys Leu Leu Asp Ser Leu Lys Asp Ala Ala His Gln Phe Phe Asn Gln 
            100                 105                 110         


Leu Val Glu Lys Lys Ala Val Tyr Leu Lys Gly Val Ser Pro Ser Pro 
        115                 120                 125             


Met Val Lys Tyr Gly Thr Ser Phe Asn Pro Asp Lys Glu Lys Ala Leu 
    130                 135                 140                 


Glu Trp Lys Asp Tyr Val Ser Met Ile Tyr Thr Asn Asp Asp Asp Ala 
145                 150                 155                 160 


His Met Phe Trp Pro Asn Glu Cys Lys Glu Val Ala Leu Glu Phe Ile 
                165                 170                 175     


Lys Thr Thr Asn Gln Met Val Gln Arg Leu Phe Gln Ala Leu Ile Thr 
            180                 185                 190         


Ser Leu Gly Val Lys Leu Asp Asp Ser Arg Phe Asp Glu Leu Ile Gly 
        195                 200                 205             


Phe Arg Met Val Asn Met Asn Tyr Tyr Pro Ala Cys Pro Asn Pro Asp 
    210                 215                 220                 


Leu Thr Val Gly Val Gly Lys His Ser Asp Met Gly Thr Leu Thr Val 
225                 230                 235                 240 


Leu Leu Gln Asp Gly Ile Gly Gly Leu Tyr Val Lys Lys Gly Asp Asp 
                245                 250                 255     


Ser Ser Pro Gly Ser Glu Glu Trp Ile Glu Ile Pro Pro Ala His Gly 
            260                 265                 270         


Ala Leu Val Ile Asn Val Gly Asp Thr Leu Gln Ile Leu Ser Asn Gly 
        275                 280                 285             


Arg Tyr Lys Ser Ala Glu His Arg Val Arg Thr Thr Ser Val Glu Ser 
    290                 295                 300                 


Arg Val Ser Ile Pro Ile Phe Thr Ala Pro Leu Pro Met Thr Lys Ile 
305                 310                 315                 320 


Gly Pro Leu Ala Glu Leu Val Ala Arg Asp Gly Val Ala Arg Tyr Arg 
                325                 330                 335     


Glu Leu Leu Phe Glu Glu Tyr Met Asn Asn Phe Phe Ala Asn Ser His 
            340                 345                 350         


Asp Gly Lys Lys Ser Leu Asp Phe Ala Ser Thr Thr 
        355                 360                 


<210>  375
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  375

Met Asp Cys Pro Ser Asp Trp Pro Glu Pro Ile Val Arg Val Gln Met 
1               5                   10                  15      


Leu Ser Glu Thr Glu Asn Lys Ile Ile Pro Thr Arg Tyr Val Lys Pro 
            20                  25                  30          


Leu Leu Glu Arg Pro Ser Phe Asn Lys Gly Asp Gln Gly Asn Ser Asn 
        35                  40                  45              


Ile Pro Leu Ile Asp Leu Phe Asp Leu Thr Asn Gly Asp Ala Arg Ala 
    50                  55                  60                  


Lys Lys Ala Ile Met Asp Lys Ile Ser Ile Ala Cys Arg Glu Trp Gly 
65                  70                  75                  80  


Phe Phe Gln Val Val Asn His Gly Met Ser Ser His Leu Val Asp Glu 
                85                  90                  95      


Ala Arg Glu Val Trp Arg Glu Phe Phe His Gln Pro Met Glu Leu Lys 
            100                 105                 110         


Gln Glu Tyr Ala Asn Thr Pro Lys Thr Tyr Glu Gly Tyr Gly Ser Arg 
        115                 120                 125             


Leu Gly Ile Gln Lys Gly Ala Ile Leu Asp Trp Ser Asp Tyr Tyr Phe 
    130                 135                 140                 


Leu Asn Tyr Leu Pro Ser Thr Leu Lys Asp His Asn Lys Trp Pro Ser 
145                 150                 155                 160 


Gln Pro Pro Leu Leu Arg Asn Val Thr Glu Glu Tyr Ser Asn Glu Ile 
                165                 170                 175     


Val Arg Leu Gly Lys Leu Leu Leu Lys Leu Phe Ser Ile Asn Leu Gly 
            180                 185                 190         


Leu Gln Glu Asp Tyr Leu Gln Asp Ala Phe Gly Gly Asp Asp Ile Gly 
        195                 200                 205             


Ala Cys Leu Arg Val Asn Phe Tyr Pro Lys Cys Pro Gln Pro Asp Leu 
    210                 215                 220                 


Thr Leu Gly Leu Ser Ser His Ser Asp Pro Gly Gly Met Thr Phe Leu 
225                 230                 235                 240 


Leu Pro Asp Glu His Val Ser Gly Leu Gln Val Arg Lys Gly Gly Glu 
                245                 250                 255     


Trp Ile Thr Val Lys Pro Ala Arg His Ala Ile Ile Val Asn Ile Gly 
            260                 265                 270         


Asp Gln Ile Gln Val Leu Thr Asn Ala Ile Tyr Lys Ser Val Glu His 
        275                 280                 285             


Arg Val Ile Val Asn Pro Asp Lys Glu Arg Val Ser Leu Ala Tyr Phe 
    290                 295                 300                 


Val Asn Pro Lys Ser Asp Ile Leu Ile Lys Pro Ala Thr Glu Leu Leu 
305                 310                 315                 320 


Thr Ser Asn Thr Pro Ala Leu Tyr Ser Pro Met Thr Phe Asp Glu Tyr 
                325                 330                 335     


Arg Leu Phe Ile Arg Thr Lys Gly Pro Gln Gly Lys Ser Gln Val Glu 
            340                 345                 350         


Ser Leu Lys Ser Ser Arg 
        355             


<210>  376
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  376

Met Pro Ile Pro Val Ile Asp Phe Ser Lys Leu Asp Gly Glu Gly Arg 
1               5                   10                  15      


Ala Lys Thr Met Ala Gln Ile Ala Asn Gly Cys Glu Glu Trp Gly Phe 
            20                  25                  30          


Phe Gln Leu Val Asn His Gly Ile Pro Leu Glu Leu Leu Ala Arg Val 
        35                  40                  45              


Lys Arg Val Ser Ser Asp Phe Tyr Lys Leu Glu Arg Glu Glu Asn Phe 
    50                  55                  60                  


Ile Lys Asn Ser Pro Ser Val Lys Gln Leu Lys Glu Leu Val Asp Lys 
65                  70                  75                  80  


Lys Asn Glu Asp Lys Leu Glu Asn Asn Asp Trp Glu Asp Val Ile Leu 
                85                  90                  95      


Leu Ser Asp Asp Asn Glu Trp Pro Thr Lys Thr Pro Gly Phe Lys Glu 
            100                 105                 110         


Thr Met Met Ala Tyr Arg Glu Glu Leu Lys Lys Leu Ala Glu Lys Leu 
        115                 120                 125             


Met Glu Val Met Asp Glu Asn Leu Gly Ile Pro Lys Gly Tyr Ile Lys 
    130                 135                 140                 


Lys Ala Phe Lys Gly Gly Glu Gly Asp Lys Ala Phe Phe Gly Thr Lys 
145                 150                 155                 160 


Val Ser His Tyr Pro Pro Cys Pro His Pro Glu Met Val Asn Gly Leu 
                165                 170                 175     


Arg Ala His Thr Asp Ala Gly Gly Ile Ile Leu Leu Phe Gln Asp Asp 
            180                 185                 190         


Glu Val Glu Gly Leu Glu Ile Leu Lys Asp Gly Lys Trp Ile Asp Val 
        195                 200                 205             


Gln Pro Ile Pro Asn Ser Ile Val Ile Asn Thr Gly Asp Gln Ile Glu 
    210                 215                 220                 


Val Leu Ser Asn Gly Lys Tyr Lys Ser Val Trp His Arg Val Gln Ala 
225                 230                 235                 240 


Met Pro Asp Arg Thr Arg Arg Ser Ile Ala Ser Phe Tyr Asn Pro Ser 
                245                 250                 255     


Tyr Asn Ala Thr Ile Glu Pro Ala Ala Gln Leu Val Glu Lys Glu Asn 
            260                 265                 270         


Ser Asp Val Asn Gln Ser Gly Tyr Pro Lys Phe Val Phe Ser Asp Tyr 
        275                 280                 285             


Met Ser Ile Tyr Thr Glu Gln Lys Phe Leu Pro Lys Glu Pro Arg Phe 
    290                 295                 300                 


Gln Ala Val Arg Thr Val Tyr 
305                 310     


<210>  377
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  377

Met Ala Pro Ser Phe Asn Asp Glu Asn Ser Leu Phe Asn Phe Val Val 
1               5                   10                  15      


Lys Asp Gly Asn Gly Val Lys Gly Leu Val Asp Ser Gly Leu Thr Glu 
            20                  25                  30          


Val Pro Gly Gln Tyr Ile Gln Pro Pro Ile His Arg Ile Lys Lys Gln 
        35                  40                  45              


Asn Ala Ser Val Ser Leu Glu Asn Met Thr Phe Asp Leu Ser Glu Leu 
    50                  55                  60                  


Asp Gly Pro Asn His Asp Gln Val Val Lys Ser Ile Ala His Ala Ala 
65                  70                  75                  80  


Glu Thr Leu Gly Phe Phe Gln Val Val Asn His Gly Val Pro Ile Glu 
                85                  90                  95      


Leu Leu Glu Ser Leu Lys Val Ser Ala His Glu Phe Phe Asn Gln Pro 
            100                 105                 110         


Ser Glu Lys Lys Ala Val Tyr Leu Lys Gly Val Ser Pro Ser Pro Met 
        115                 120                 125             


Val Lys Tyr Gly Thr Ser Phe Val Pro Glu Lys Glu Lys Ala Leu Glu 
    130                 135                 140                 


Glu Val Val Leu Lys Tyr Ile Lys Thr Ser Arg Glu Met Val Lys Arg 
145                 150                 155                 160 


Leu Leu Gln Ala Leu Met Glu Asn Leu Gly Val Lys Leu Asp Asp Ser 
                165                 170                 175     


Lys Leu Asp Ala Leu Met Ser Phe Arg Leu Val Asn Met Asn Phe Tyr 
            180                 185                 190         


Pro Thr Cys Pro Asn Pro Asp Leu Thr Val Gly Val Gly Arg His Ser 
        195                 200                 205             


Asp Ile Ser Thr Leu Thr Val Leu Leu Gln Asp Gly Ile Gly Gly Leu 
    210                 215                 220                 


Tyr Val Lys Lys Asp Ala Asp Leu Pro Thr Gly Asn Glu Asp Trp Ile 
225                 230                 235                 240 


Glu Ile Pro Pro Val His Gly Ala Leu Val Ile Asn Ile Gly Asp Ala 
                245                 250                 255     


Leu Gln Ile Ile Ser Asn Gly Arg Tyr Lys Ser Ala Glu His Arg Val 
            260                 265                 270         


Arg Thr Thr Ile Val Gln Ser Arg Val Ser Ala Pro Ile Phe Asn Gly 
        275                 280                 285             


Pro Leu Pro Val Ala Lys Ile Gly Pro Leu Ala Glu Leu Val Ala Arg 
    290                 295                 300                 


Asp Gly Val Ala Arg Tyr Arg Glu Val Ile Phe Glu Asp Tyr Met Lys 
305                 310                 315                 320 


Asn Phe Tyr Ala Lys Ser His Asp Gly Lys Lys Ser Leu Asp Phe Val 
                325                 330                 335     


Thr Ile 
        


<210>  378
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  378

Met Val Met Ser Gly Thr Pro Val Ile Asp Met Gln Met Val Asp Gly 
1               5                   10                  15      


Leu Ala Asp Glu Ile Val Lys Ala Cys Val Glu Phe Gly Cys Phe Arg 
            20                  25                  30          


Val Val Asn His Gly Val Ser Ala Glu Leu Met Thr Glu Met Lys Ala 
        35                  40                  45              


Val Val Ser Ser Leu Phe Asp Leu Pro Glu Glu Ile Lys Arg Arg Thr 
    50                  55                  60                  


Ala Asn Pro Asn Glu His Gly Lys Gly Tyr Ile Gly Arg Asn His Ile 
65                  70                  75                  80  


Asp Gln Leu His Phe Ser Arg Val Leu Val Leu Met Lys Phe Arg Ile 
                85                  90                  95      


Leu Ile Asn Phe Leu Ile Val Leu Val Pro Pro Phe Thr Lys Val Tyr 
            100                 105                 110         


Leu Gly Val Thr Val Thr Phe Thr Tyr Cys His Lys Leu Thr Asn His 
        115                 120                 125             


Ser Phe Val Arg Pro Thr Asp Ile Ile Asn Arg Tyr Ile Lys Ala Ile 
    130                 135                 140                 


Arg Asp Leu Asn Gly Leu Leu Gly Arg Lys Leu Ile Glu Gly Asn Gly 
145                 150                 155                 160 


Leu Asn Gly Asp Leu Phe Asp Gly Trp Cys Cys Gln Leu Arg Met Asn 
                165                 170                 175     


Lys Tyr His Phe Ser Ala Glu Ser Ile Gly Leu Thr Cys Ala Pro Ile 
            180                 185                 190         


His Ser Asp Pro Thr Phe Leu Thr Ile Leu Pro Asp Asp Glu Cys Val 
        195                 200                 205             


Asn Gly Leu Gln Leu Val Asp Lys Ile Ser Gly Glu Phe Val Pro Phe 
    210                 215                 220                 


Asp Pro Val Pro Gly Thr Leu Ala Val Asn Ile Gly Asp Ile Gly Lys 
225                 230                 235                 240 


Ala Trp Ser Asn Gly Arg Tyr Tyr Asn Val Asn His Arg Val Leu Cys 
                245                 250                 255     


Phe Glu Pro Asn Thr Arg Tyr Ser Ile Ala Leu Phe Val Leu Gly Pro 
            260                 265                 270         


Asn Asn Lys Ile Val Glu Ala Pro Ser Lys Leu Val Asp Ser Glu His 
        275                 280                 285             


Pro Arg Leu Tyr Val Pro Ile Asp Val Glu Lys Phe Arg His Val Arg 
    290                 295                 300                 


Asn Thr Met Gly Leu Arg Thr Gly Asp Ala Leu Asp Leu Phe Ser Thr 
305                 310                 315                 320 


Thr Ser Thr 
            


<210>  379
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  379

Met Glu Asn Met Val Thr Lys Trp Cys Thr Thr Val Lys Ser Val Pro 
1               5                   10                  15      


Gln Asp Tyr Val Phe Pro Glu Gly Ile Arg Pro Gly Asp Gln Val Val 
            20                  25                  30          


Pro Ser Ala Ser Gln Asp Ser Gly Phe Phe Gln Val Ile Asn His Gly 
        35                  40                  45              


Ile Asn Glu Asp Leu Ile His Glu Ala Met Glu Val Ile Lys Glu Leu 
    50                  55                  60                  


Phe Asn Met Pro Asp Glu Asp Ile Thr Lys Ile Tyr Ser Leu Asp His 
65                  70                  75                  80  


His Lys Ser Cys Arg Leu Tyr Thr Ser Ser Phe Asp Tyr Val Ser Glu 
                85                  90                  95      


Ser Thr His Leu Trp Arg Asp Ile Leu Lys His Pro Cys His Pro Leu 
            100                 105                 110         


Glu Asp Trp Val His Leu Trp Pro Glu Lys Pro Ser Lys Tyr Arg Asp 
        115                 120                 125             


Val Leu Gly Lys Phe Ser Val Glu Val Arg Asn Leu Ser Phe Arg Ile 
    130                 135                 140                 


Leu Glu Met Ile Arg Glu Gly Leu Gly Leu Lys Pro Gly Tyr Phe Gly 
145                 150                 155                 160 


Asp Glu Leu Thr Gly Ile Gln Met Phe Ser Val Asn His Tyr Pro Pro 
                165                 170                 175     


Cys Pro Glu Pro Ser Leu Ala Leu Gly Ile Ser Lys His Arg Asp Pro 
            180                 185                 190         


Asn Ile Leu Thr Ile Leu Tyr Gln Gly Asn Thr Arg Gly Leu Gln Val 
        195                 200                 205             


Leu Lys Asp Gly Gln Trp Phe Gly Val Glu Pro Tyr Asp Asn Ala Phe 
    210                 215                 220                 


Val Val Asn Ile Gly Gln Gln Leu Lys Val Ile Thr Asn Gly Lys Phe 
225                 230                 235                 240 


Glu Ser Ser Glu His Arg Val Val Thr Asn Ser Lys Glu Ser Arg Tyr 
                245                 250                 255     


Thr Ile Ala Ser Phe Ile Asn Pro His Ser Asp Thr Val Ile Gly Pro 
            260                 265                 270         


Glu Lys Ser Ile Val Asp Lys Asp Asn Gly Arg Pro Leu Tyr Gln Thr 
        275                 280                 285             


Phe Arg Tyr Lys Asp Phe His Arg Ala Tyr Gln Ala His Lys Gly Glu 
    290                 295                 300                 


Gly Glu Ala Thr Ile Gly Val Phe Lys Ile Asp Gly 
305                 310                 315     


<210>  380
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  380

Met Val Ile Pro Thr Asn Thr Arg Val Glu Thr Leu Ala Thr Ser Gly 
1               5                   10                  15      


Ile His Gln Ile Pro Lys Glu Tyr Ile Arg Thr Gln Asp Glu Leu Thr 
            20                  25                  30          


Thr Ile Thr Asn Ile Phe Asp Glu Glu Lys Lys Glu Leu Gly Pro Gln 
        35                  40                  45              


Val Pro Thr Ile Asp Leu Asn Asn Ile Asn Ser Lys Asp Pro Lys Thr 
    50                  55                  60                  


Arg Glu Lys Cys Cys Asn Glu Leu Val Lys Ala Ala Thr Glu Trp Gly 
65                  70                  75                  80  


Val Met His Ile Val Asn His Gly Ile Ser Ser Asp Leu Ile Asn Arg 
                85                  90                  95      


Val Lys Asp Ala Gly Glu Arg Phe Phe Asp Gln Pro Val Glu Glu Lys 
            100                 105                 110         


Glu Lys Tyr Ser Asn Asp Ile Ala Thr Gly Lys Ile Gln Gly Tyr Gly 
        115                 120                 125             


Ser Lys Leu Ala Asn Asn Ala Cys Gly Gln Leu Glu Trp Glu Asp Tyr 
    130                 135                 140                 


Phe Phe His Leu Val Phe Pro Glu Glu Lys Arg Asp Leu Thr Val Trp 
145                 150                 155                 160 


Pro Ser Thr Pro Ser Glu Tyr Ile Pro Ala Thr Ala Glu Tyr Ala Arg 
                165                 170                 175     


Gln Leu Arg Ala Leu Thr Thr Lys Ile Leu Ala Val Leu Ser Leu Gly 
            180                 185                 190         


Leu Gly Leu Glu Glu Gly Arg Leu Glu Asp Glu Val Gly Gly Leu Glu 
        195                 200                 205             


Glu Leu Ile Leu Gln Phe Lys Ile Asn Tyr Tyr Pro Lys Cys Pro Gln 
    210                 215                 220                 


Pro Glu Leu Ala Leu Gly Val Glu Ala His Thr Asp Val Ser Ala Leu 
225                 230                 235                 240 


Thr Phe Ile Leu His Asn Met Val Pro Gly Leu Gln Leu Phe Tyr Asp 
                245                 250                 255     


Gly Gln Trp Val Thr Ala Lys Cys Val Pro Asp Ser Ile Ile Met His 
            260                 265                 270         


Ile Gly Asp Thr Leu Glu Ile Leu Ser Asn Gly Lys Tyr Lys Ser Ile 
        275                 280                 285             


Leu His Arg Gly Leu Val Asn Lys Glu Lys Val Arg Ile Ser Trp Ala 
    290                 295                 300                 


Val Phe Cys Glu Pro Pro Lys Asp Lys Ile Ile Leu Lys Pro Leu Pro 
305                 310                 315                 320 


Glu Thr Ile Ser Lys Glu Asn Pro Pro Leu Phe Pro Pro Arg Thr Phe 
                325                 330                 335     


His Gln His Met Glu His Lys Leu Phe Lys Lys Lys Asp His Ser Val 
            340                 345                 350         


Glu Pro Lys 
        355 


<210>  381
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  381

Met Pro Ile Pro Val Ile Asp Phe Ser Lys Leu Asn Gly Glu Glu Arg 
1               5                   10                  15      


Ala Lys Thr Met Ala Glu Ile Ala Asn Gly Cys Glu Glu Trp Gly Phe 
            20                  25                  30          


Phe Gln Leu Val Asn His Gly Ile Pro Val Glu Leu Leu Glu Arg Val 
        35                  40                  45              


Lys Lys Val Thr Ser Glu Cys Tyr Lys Phe Glu Arg Glu Glu Glu Phe 
    50                  55                  60                  


Phe Lys Asn Ser Thr Pro Val Lys Leu Leu Lys Glu Leu Val Asp Lys 
65                  70                  75                  80  


Lys Ser Glu Glu Lys Leu Glu Asn Ile Asp Trp Glu Asp Val Phe Leu 
                85                  90                  95      


Leu Ala Asp Asp Asn Glu Trp Pro Pro Lys Thr Pro Gly Phe Lys Glu 
            100                 105                 110         


Thr Met Met Glu Tyr Arg Ala Glu Leu Lys Lys Leu Ser Glu Lys Leu 
        115                 120                 125             


Met Glu Ile Met Asp Glu Asn Leu Gly Ile Pro Lys Gly Tyr Ile Lys 
    130                 135                 140                 


Lys Ala Phe Asn Gly Gly Glu Gly Asp Gln Ala Phe Phe Gly Thr Lys 
145                 150                 155                 160 


Val Ser His Tyr Pro Pro Cys Ser His Pro Glu Met Val Asn Gly Leu 
                165                 170                 175     


Arg Ala His Thr Asp Ala Gly Gly Val Ile Leu Leu Phe Gln Asp Asp 
            180                 185                 190         


Glu Val Gly Gly Leu Glu Val Leu Lys Asp Gly Lys Trp Thr Asp Val 
        195                 200                 205             


Gln Pro Ile Pro Asn Ala Ile Cys Ile Asn Thr Gly Asp Gln Ile Glu 
    210                 215                 220                 


Val Leu Ser Asn Gly Lys Tyr Lys Ser Ala Trp His Arg Val Gln Ala 
225                 230                 235                 240 


Met Pro Asn Gly Thr Arg Arg Ser Ile Ala Ser Phe Tyr Asn Pro Ser 
                245                 250                 255     


Tyr Asp Ala Thr Ile Glu Pro Ala Thr His Leu Val Lys Lys Glu Asn 
            260                 265                 270         


Lys Glu Phe Asn Gln Ser Ser Tyr Pro Lys Phe Val Phe Gly Asp Tyr 
        275                 280                 285             


Met Ser Val Tyr Thr Glu Gln Lys Phe Leu Ala Lys Glu Pro Arg Phe 
    290                 295                 300                 


Gln Ala Val Lys Ala Val 
305                 310 


<210>  382
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  382

Met Val Val Pro Ser Asn Glu Ile Asn Pro Ile Arg Asn Glu Lys Ile 
1               5                   10                  15      


Arg Glu Val Glu Val Pro Val Ile Asp Leu Ser Gly Lys Arg Ser Lys 
            20                  25                  30          


Val Ala Lys Leu Ile Val Lys Ala Cys Glu Glu Tyr Gly Phe Phe Lys 
        35                  40                  45              


Val Ile Asn His Gly Val Pro His His Ile Ile Lys Asn Met Glu Asp 
    50                  55                  60                  


Glu Ser Phe Glu Phe Phe Asp Lys Pro Leu Val Glu Lys Glu Gln Val 
65                  70                  75                  80  


Gly Ser Asn Asn Pro Phe Gly Tyr Gly Cys Lys Asn Ile Gly Leu Gly 
                85                  90                  95      


Gly Asp Thr Gly Glu Leu Glu Tyr Leu Leu Leu Gln Ala Asn Gln Thr 
            100                 105                 110         


Ser Ile His His Thr Ser Glu Phe Ser Cys Ala Val Ser Asn Tyr Val 
        115                 120                 125             


Glu Gly Val Lys Glu Leu Thr Cys Glu Ile Leu Glu Leu Ile Ala Lys 
    130                 135                 140                 


Gly Leu Glu Val Pro His Ser Ser Phe Ser Gln Met Val Arg Ser Leu 
145                 150                 155                 160 


Asp Ser Asp Ser Leu Leu Arg Leu Asn His Tyr Pro Pro Val Ser Asp 
                165                 170                 175     


Thr Ser His Thr Phe Pro Arg Gly Ser Asn Ser Thr Ser Ile Gly Phe 
            180                 185                 190         


Gly Glu His Ser Asp Pro Gln Ile Leu Thr Val Leu Arg Ser Asn Gly 
        195                 200                 205             


Val Ala Gly Leu Gln Ile Ser Leu Gly Asn Asp Val Trp Val Pro Val 
    210                 215                 220                 


Ser Pro Asn Pro Leu Ala Phe Cys Val Asn Val Gly Asp Val Leu Gln 
225                 230                 235                 240 


Ala Met Thr Asn Gly Arg Phe Val Ser Val Arg His Arg Ala Met Ala 
                245                 250                 255     


Asn Thr Ser Leu Asn Glu Ser Arg Leu Ser Met Val Phe Phe Gly Ala 
            260                 265                 270         


Pro Pro Pro Glu Ala Ile Ile Thr Cys Pro Pro Glu Leu Leu Lys Glu 
        275                 280                 285             


Asn Glu Pro Leu Tyr Lys Val Phe Thr Trp Ala Glu Tyr Lys Ser His 
    290                 295                 300                 


Thr Tyr Ala His Arg Leu Ala Val Thr Arg Leu Asp His Phe Asn Ile 
305                 310                 315                 320 


Ala 
    


<210>  383
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  383

Met Ser Thr Phe Thr Thr Ile Pro Cys Ile Lys Phe Ile Thr Ile Gln 
1               5                   10                  15      


Ser His Phe Ile Asn His Leu Thr Met Gly Gln Val Asp Pro Thr Phe 
            20                  25                  30          


Ile Gln Glu Leu Glu His Arg Pro Lys Pro Val Val Ile Glu Ala Gln 
        35                  40                  45              


Gly Ile Pro Gln Ile Asp Leu Ser Pro Ser Val Pro Ile Gln Glu Leu 
    50                  55                  60                  


Val Asp Gln Ile His Asp Ala Cys Lys Asn Trp Gly Phe Phe Gln Val 
65                  70                  75                  80  


Ile Asn His Gly Val Pro Ile Glu Ser Arg Glu Lys Val Gln Lys Ala 
                85                  90                  95      


Ala Lys Arg Phe Phe Asp Gln Thr Thr Glu Glu Lys Arg Lys Val Lys 
            100                 105                 110         


Arg Asp Glu Ala Asn Pro Leu Gly Tyr Tyr Asp Thr Glu His Thr Lys 
        115                 120                 125             


Asn Val Arg Asp Trp Lys Glu Val Phe Asp Phe Val Val Glu Val Pro 
    130                 135                 140                 


Thr Leu Met Ser Ala Ser Tyr Glu Ala Asp Asp Asp Glu Ile Thr Glu 
145                 150                 155                 160 


Tyr Arg Asn Gln Trp Pro His His Pro Ser Glu Leu Arg Glu Ala Cys 
                165                 170                 175     


Glu Glu Tyr Val Lys Asp Val Gln Lys Leu Ser Asn Lys Leu Leu Glu 
            180                 185                 190         


Leu Ile Ser Leu Ser Leu Asn Leu Pro Ala Lys Arg Leu Glu Pro Phe 
        195                 200                 205             


Phe Lys Asp Gln Thr Thr Phe Val Arg Leu Asn His Tyr Pro Pro Cys 
    210                 215                 220                 


Leu Ala Pro Asp Leu Ala Leu Gly Val Gly Arg His Lys Asp Ala Gly 
225                 230                 235                 240 


Ala Leu Thr Ile Leu Ala Gln Asp Asp Val Gly Gly Leu Glu Val Lys 
                245                 250                 255     


Arg Lys Thr Asp Gly Glu Trp Ile Phe Val Lys Pro Thr Pro Asn Ala 
            260                 265                 270         


Phe Ile Ile Asn Val Gly Asp Ile Ile Gln Val Tyr His Arg Asp Asn 
        275                 280                 285             


Ile Gly Leu 
    290     


<210>  384
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  384

Met Asp Lys Leu Leu Ser Ser Trp Ser Ser Ser Ala Lys Ser Leu Pro 
1               5                   10                  15      


Glu Ser Tyr Val Phe Pro Val Asp Ser Arg Pro Gly Asp Thr Asn Val 
            20                  25                  30          


Pro Phe Cys Asn Thr Phe Pro Val Ile Asp Leu Glu Ala Ala Leu Ala 
        35                  40                  45              


Asn Asp Arg His Asp Ala Ile Gln Gln Ile Leu Lys Ala Cys Gln Asp 
    50                  55                  60                  


Phe Gly Phe Phe Gln Val Ile Asn His Gly Val Asn Asn Asp Leu Val 
65                  70                  75                  80  


Ser Asp Thr Met Asn Val Val Lys Glu Phe Phe Asn Met Pro Asn Glu 
                85                  90                  95      


Asp Lys Ala Ser Val Tyr Ser Glu Asp Pro Ser Lys Lys Cys Arg Leu 
            100                 105                 110         


Tyr Thr Ser Thr Tyr Asp Tyr Asp Asn Glu Lys Val His Leu Trp Arg 
        115                 120                 125             


Asp Asn Leu Arg His His Cys His Pro Ile Glu Asp Phe Ile Asn Leu 
    130                 135                 140                 


Trp Pro Gln Lys Pro Ala Arg Tyr Arg Asp Val Val Arg Glu Tyr Ser 
145                 150                 155                 160 


Leu Gln Val Asp Asn Leu Ser Ser Arg Ile Leu Glu Leu Ile Ser Glu 
                165                 170                 175     


Gly Leu Gly Leu Glu Pro Gly Tyr Phe Gly Asp Gly Leu Thr Gly Ser 
            180                 185                 190         


Gln Leu Phe Ser Val Asn His Tyr Pro Pro Cys Pro Asn Pro Asn Leu 
        195                 200                 205             


Ala Leu Gly Leu Pro Lys His Cys Asp Ala Cys Leu Ile Thr Phe Leu 
    210                 215                 220                 


Leu Gln Asp Glu Met Tyr Gly Leu Gln Val Tyr Arg Asn Gly Glu Trp 
225                 230                 235                 240 


Phe Gly Val Gln Pro Ile Pro Asn Ala Phe Val Val Ile Leu Gly His 
                245                 250                 255     


Gln Ala Gln Val Ile Ser Asn Gly Lys Leu Ile Ser Pro Glu His Arg 
            260                 265                 270         


Ala Ile Thr Asn Ser Lys Asn His Arg Thr Ser Ile Val Tyr Ser Ile 
        275                 280                 285             


Asn Pro Lys Pro Asp Thr Ile Ile Glu Pro Ala Lys Ala Leu Ile Asn 
    290                 295                 300                 


Lys Ser Asn Tyr Pro Leu Tyr Arg Ala Phe Gln Phe Lys Glu Phe Leu 
305                 310                 315                 320 


Lys Ala Tyr Glu Val Lys Lys Asp Tyr Asn Glu Gly Ala Leu Glu Asp 
                325                 330                 335     


Phe Lys Ile Lys Glu Glu Leu Lys Glu Glu Ser Ser His Lys Thr Arg 
            340                 345                 350         


Asp Gln Gly Cys Glu Asn Gln Leu Gly Asp Leu His Leu Thr Lys 
        355                 360                 365         


<210>  385
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  385

Met Glu Val Glu Arg Val Gln Glu Ile Ala Thr Leu Ser Asn Leu Asn 
1               5                   10                  15      


Gly Thr Ile Pro Ser Glu Phe Ile Arg Leu Asp Asn Glu Gln Pro Ala 
            20                  25                  30          


Ser Thr Thr Leu His Gly Val Val Leu Glu Val Pro Val Ile Asp Leu 
        35                  40                  45              


Ser Gln Thr Asp Asn Glu Ser Leu Val Asp Leu Ile Ser Lys Ala Ser 
    50                  55                  60                  


Lys Asp Trp Gly Leu Phe Gln Val Val Asn His Gly Ile Pro Ser Glu 
65                  70                  75                  80  


Leu Ile Ser Lys Leu Gln Lys Val Gly Lys Glu Phe Phe Glu Leu Pro 
                85                  90                  95      


Gln Glu Glu Lys Glu Val Ile Ala Lys Pro Asp Gly Tyr Lys Gly Val 
            100                 105                 110         


Glu Gly Tyr Gly Thr Lys Leu Gln Lys Glu Val Gln Gly Lys Lys Gly 
        115                 120                 125             


Trp Val Asp His Leu Phe His Ile Val Trp Pro Pro Ser Ser Ile Asn 
    130                 135                 140                 


Tyr Gln Phe Trp Pro Lys Asn Pro Pro Ser Tyr Arg Asp Thr Asn Glu 
145                 150                 155                 160 


Glu Tyr Ala Gln Ser Leu Ile Gly Val Ala Asn Lys Leu Leu Gly Leu 
                165                 170                 175     


Leu Ser Lys Gly Leu Gly Leu Glu Glu Asp Glu Val Lys Gln Ala Leu 
            180                 185                 190         


Gly Gly Glu Asp Leu Val Tyr Met Leu Lys Ile Asn Tyr Tyr Pro Pro 
        195                 200                 205             


Cys Pro Cys Pro Glu Leu Ala Leu Gly Val Ala Pro His Thr Asp Met 
    210                 215                 220                 


Ser Ser Ile Thr Ile Leu Val Pro Asn Glu Val Gln Gly Leu Gln Val 
225                 230                 235                 240 


Phe Lys Asp Gly Asp Trp Tyr Asp Val Ala Tyr Ile Pro Asn Ala Leu 
                245                 250                 255     


Ile Ile His Ile Gly Asp Gln Ile Glu Ile Leu Ser Asn Gly Lys Tyr 
            260                 265                 270         


Lys Ser Val Tyr His Arg Thr Thr Val Asn Lys Glu Lys Thr Arg Met 
        275                 280                 285             


Ser Trp Pro Val Phe Leu Glu Pro Pro Leu Glu Phe Glu Val Gly Pro 
    290                 295                 300                 


Ile Pro Lys Leu Val Asn Lys Asp Asp Pro Pro Lys Tyr Lys Thr Lys 
305                 310                 315                 320 


Lys Tyr Lys Asp Tyr Val Tyr Cys Lys Leu Asn Lys Leu Pro Gln 
                325                 330                 335 


<210>  386
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  386

Met Glu Pro Asp Ser Ser Phe Thr Ser Val Met Ala Leu Thr Leu Glu 
1               5                   10                  15      


Arg Gln Lys Asn Ile Pro Glu Gln Tyr Val Leu Pro Pro Leu Gln Arg 
            20                  25                  30          


Pro Asn Met Ser Leu Thr Asp His Ile Pro Thr Ser Leu Pro Leu Ile 
        35                  40                  45              


Asp Leu Ser Met Ile Asn His Pro Ala His Arg Ser Gln Val Ile Asp 
    50                  55                  60                  


Glu Val His Ala Ala Cys Lys Gln Leu Gly Phe Phe Gln Val Ile Asn 
65                  70                  75                  80  


His Gly Ile Pro Thr Ser Val Leu Lys Asp Ala Leu Asp Ser Ala Glu 
                85                  90                  95      


Glu Phe Phe Asn Leu Pro Ser Glu Glu Lys Met Cys Phe Ala Ser Ala 
            100                 105                 110         


Asp Val His Glu Pro Val Arg Tyr Gly Thr Ser Met Asn His Gly Lys 
        115                 120                 125             


Asp Lys Val Phe Tyr Trp Arg Asp Phe Leu Lys Leu Tyr Ala Asn Pro 
    130                 135                 140                 


Ile Ser Glu Trp Ile His Leu Trp Pro Ser Asn Pro Pro Ser Tyr Arg 
145                 150                 155                 160 


Glu Lys Met Gly Ser Tyr Ala Asp Ala Met His Thr Leu Gln Lys Arg 
                165                 170                 175     


Leu Met Glu Val Val Leu Glu Ser Leu Gly Leu Asn Ala Asn Tyr Leu 
            180                 185                 190         


His Glu Asp Ile Asp Glu Gly Ser Gln Val Leu Ala Val Asn Cys Tyr 
        195                 200                 205             


Pro Ser Cys Pro Glu Pro Asp Leu Ala Leu Gly Met Pro Pro His Thr 
    210                 215                 220                 


Asp Tyr Gly Thr Leu Thr Ile Leu Asn Gln Ser His Gln Gly Leu Glu 
225                 230                 235                 240 


Ile Met Asp His Asp Lys Lys Trp His Ser Val Pro Phe Ile Glu Gly 
                245                 250                 255     


Ala Leu Ile Val Gln Leu Gly Asp Gln Ser Glu Val Met Ser Asn Gly 
            260                 265                 270         


Arg Tyr Lys Gly Thr Pro His Arg Ala Ile Leu Asn Thr Gln Lys Lys 
        275                 280                 285             


Arg Leu Ser Ile Ala Ser Leu His Ser Leu Ala Ile Glu Lys Lys Ile 
    290                 295                 300                 


Gly Pro Ala Pro Glu Leu Val Asp Glu Gln His Pro Val Ala Tyr Lys 
305                 310                 315                 320 


Glu Gly Ser Phe Ala Glu Phe Leu Asp Cys Ile Ala Leu Asn Ser Val 
                325                 330                 335     


Ser Asp Val Lys Tyr Ile Asp Thr Leu Arg Ile His 
            340                 345             


<210>  387
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  387

Met Ala Thr Ile Thr Pro Leu Ile Thr Ser Ser Tyr Asp Arg Ala Ser 
1               5                   10                  15      


Glu Ile Lys Ala Phe Asp Glu Thr Lys Thr Gly Val Gln Gly Leu Val 
            20                  25                  30          


Asp Ala Ala Ile Gln Gln Ile Pro Arg Ile Phe Ile Asn Pro Pro Glu 
        35                  40                  45              


Pro Ile Pro Lys Ser Thr Thr Ser Phe Asp Ile Pro Leu Ile Asp Leu 
    50                  55                  60                  


Ala Ser Thr Asn Arg Ala Leu Ile Val Glu Ser Ile Arg Lys Ala Ser 
65                  70                  75                  80  


Glu Asn Leu Gly Phe Phe Gln Val Val Asn His Gly Ile Pro Ile Cys 
                85                  90                  95      


Ile Met Asn Glu Thr Leu Arg Gly Val Arg Arg Phe Tyr Glu Gln Asp 
            100                 105                 110         


Val Glu Val Lys Lys Gln Phe Tyr Thr Arg Asp Ala Ser Lys Ala Phe 
        115                 120                 125             


Val Tyr Asn Ser Asn Phe Asn Leu Tyr Ser Ser Pro Ala Ala Asn Trp 
    130                 135                 140                 


Arg Asp Thr Phe Phe Ser Phe Met Ala Pro Ser Pro Pro Lys Pro Glu 
145                 150                 155                 160 


Asp Leu Pro Val Val Cys Arg Asp Ile Gln Ile Asp Tyr Ser Ser Arg 
                165                 170                 175     


Val Leu Lys Leu Gly Glu Ser Leu Phe Gly Phe Ile Ser Glu Ala Leu 
            180                 185                 190         


Gly Leu Glu Thr His His Leu Gly Asp Met Glu Cys Asp Lys Gly Leu 
        195                 200                 205             


Thr Phe Val Ala His Ile Tyr Pro Ala Cys Pro Gln Pro Glu Leu Thr 
    210                 215                 220                 


Met Gly Ala Thr Lys His Thr Asp Ile Glu Phe Leu Thr Val Leu Leu 
225                 230                 235                 240 


Gln Asp Asp Ile Gly Gly Leu Glu Val Leu His Glu Asn Gln Trp Ile 
                245                 250                 255     


Asp Val Pro Pro Thr Pro Gly Ala Leu Val Ile Asn Ile Gly Asp Leu 
            260                 265                 270         


Leu Gln Met Ile Ser Asn Asp Lys Leu Arg Ser Val Glu His Arg Val 
        275                 280                 285             


Val Ala Lys Glu Lys Gly Pro Arg Val Ser Val Ala Cys Phe Phe Ser 
    290                 295                 300                 


Thr Ser Leu Ala Pro Ser Thr Lys Val Tyr Gly Pro Ile Lys Glu Leu 
305                 310                 315                 320 


Leu Ser Asp Asp Asn Pro Pro Arg Tyr Arg Glu Thr Thr Val Gln Asp 
                325                 330                 335     


Tyr Val Glu Tyr Asn Leu Ser Lys Gly Leu Asp Gly Asp Pro Arg Leu 
            340                 345                 350         


Leu His Leu Lys Ile 
        355         


<210>  388
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  388

Met Asn His Gly Ile Glu Ser Ser Leu Leu Glu Glu Val Arg Glu Ile 
1               5                   10                  15      


Gly Ile Gln Phe Phe Lys Leu Pro Val Glu Glu Lys Lys Lys Cys Leu 
            20                  25                  30          


Arg Glu Lys Asp Asp Leu Glu Gly Tyr Gly Asn Asp Met Val Leu Ser 
        35                  40                  45              


Asn Asn Gln Thr Leu Asp Cys Asn Asp Arg Ile Tyr Leu Ala Val Val 
    50                  55                  60                  


Pro Gln His Gln Gln Lys Leu Gln Phe Trp Pro Gln Asn Pro Thr His 
65                  70                  75                  80  


Phe Gln Glu Val Leu Asn Ala Tyr Ser Ser Lys Ile Asp Leu Ile Ser 
                85                  90                  95      


Lys Val Val Gln Lys Ser Leu Ala Arg Ser Leu Asn Met Glu Glu Asp 
            100                 105                 110         


Ser Phe Leu Ser Gln Tyr Gly Thr Thr Ala Ser Ile Ser Ala Arg Tyr 
        115                 120                 125             


Asn Tyr Tyr Pro Pro Cys Pro Trp Ala Glu Lys Val Leu Gly Val Lys 
    130                 135                 140                 


Ala His Ser Asp Ser Ser Ala Ile Thr Val Leu Leu Gln Asp Lys Glu 
145                 150                 155                 160 


Val Glu Gly Leu Gln Leu Leu Arg Asp Asn Gln Trp Val Gly Val Pro 
                165                 170                 175     


Ile Leu Arg Asp Ala Leu Thr Ile Asn Val Gly Asp Gln Ile Glu Ile 
            180                 185                 190         


Met Ser Asn Gly Ile Phe Lys Ser Pro Val His Arg Leu Leu Val Asn 
        195                 200                 205             


Ser Lys Lys Glu Arg Met Thr Leu Ala Met Phe Cys Val Pro Gln Thr 
    210                 215                 220                 


Glu Met Val Ile Gly Pro Val Asp Gly Leu Ile Thr Asp Glu Thr Pro 
225                 230                 235                 240 


Arg Leu Tyr Lys Asn Gly Thr Tyr Thr Leu Asp Phe Phe Phe Lys Asp 
                245                 250                 255     


Phe Gln Gln Gly Arg Arg Ala Ile Asp Ala Cys Lys Ile 
            260                 265                 


<210>  389
<211>  1083
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  389

Met Thr Gly Ala Lys Phe Glu Ile Glu Lys Phe Asp Gly Thr Gly Asp 
1               5                   10                  15      


Phe Gly Leu Trp Arg Val Lys Met Arg Ala Leu Leu Ile Gln His Gly 
            20                  25                  30          


Cys Glu Ala Ala Leu Glu Val Leu Pro Ala Asn Met Asp Ala Thr Ala 
        35                  40                  45              


Lys Ala Glu Leu Asn Lys Lys Ala His Ser Ala Met Ile Leu Cys Leu 
    50                  55                  60                  


Gly Asn Lys Val Leu Arg Glu Val Thr Gly Glu Thr Thr Ala Ala Gly 
65                  70                  75                  80  


Val Trp Thr Lys Val Glu Thr Leu Tyr Met Thr Lys Ser Leu Ala Asn 
                85                  90                  95      


Lys Leu Tyr Leu Lys Lys Lys Leu Tyr Thr Phe Tyr Met Pro Ala Gly 
            100                 105                 110         


Arg Arg His Thr Thr Gln Gly Val Ile Asp Tyr Val His Ser Asp Leu 
        115                 120                 125             


Trp Gly Pro Ser Gln Val Glu Ser Leu Gly Gly Lys Arg Tyr Phe Leu 
    130                 135                 140                 


Ser Ile Val Asp Asp Tyr Tyr Arg Arg Val Trp Val Tyr Ile Leu Arg 
145                 150                 155                 160 


Phe Lys His Glu Ala Phe Gly Lys Phe Lys Glu Trp Lys Gln Leu Val 
                165                 170                 175     


Glu Asn Gln Thr Gly Arg Lys Ser Gly Leu Pro Lys Thr Phe Trp Ala 
            180                 185                 190         


Glu Ala Thr Cys Thr Ala Ala Tyr Leu Ile Asn Arg Ser Pro Ser Thr 
        195                 200                 205             


Ala Ile Glu Lys Lys Thr Pro Met Glu Met Trp Ser Gly His Pro Ser 
    210                 215                 220                 


Asp Tyr Gly Met Leu Arg Ile Phe Gly Cys Val Ala Tyr Ser His Val 
225                 230                 235                 240 


Lys Gln Gly Lys Leu Glu Pro Arg Ala Val Lys Cys Val Leu Leu Gly 
                245                 250                 255     


Tyr Pro Glu Gly Val Lys Gly Tyr Lys Leu Tyr Arg Leu Asp Asn Glu 
            260                 265                 270         


Ser Pro Lys Ile Val Thr Ser Arg Asn Val Val Phe Asn Glu Ser Val 
        275                 280                 285             


Met Tyr Lys Asp Thr Leu Lys Asp Ser Gly Ala Asp Gln Thr His Asp 
    290                 295                 300                 


Gln Glu Asp Ser Asp Asp Glu Asp Ala Gly Asp Gln Asp His Asp Gln 
305                 310                 315                 320 


Thr Pro Asp Leu Thr Asp Tyr Gln Leu Val Arg Asp Arg Glu Pro Arg 
                325                 330                 335     


Thr Arg Thr Lys Thr Leu Arg Phe Arg Asp Glu Ser Asn Met Ala Thr 
            340                 345                 350         


Tyr Ala Phe Ala Ala Ala Glu Glu Glu Asp Thr His Glu Pro Leu Thr 
        355                 360                 365             


Tyr Gln Glu Ala Val Ala Cys Glu Asp Asn Pro Lys Trp Lys Ala Ala 
    370                 375                 380                 


Met Asp Glu Glu Met Asp Ser Leu Lys Lys Asn Glu Thr Tyr Glu Leu 
385                 390                 395                 400 


Val Asp His Pro Ala Gly Gln Lys Leu Met Ser Tyr Lys Trp Leu Phe 
                405                 410                 415     


Lys Ile Lys Glu Gly Ile Glu Gly Val His Lys Pro Arg Tyr Lys Ala 
            420                 425                 430         


Arg Asp Tyr Glu Leu Glu Gln Leu Asp Val Lys Met Thr Phe Leu His 
        435                 440                 445             


Gly Asn Leu Glu Glu Val Ile Tyr Met Arg Gln Pro Pro Gly Tyr Glu 
    450                 455                 460                 


Gln Gly Asn Lys Ser Pro Arg Gln Trp Tyr Arg Arg Phe Asp Glu Tyr 
465                 470                 475                 480 


Met Leu Ser Asn Gly Phe Lys Arg Arg Ser Tyr Asp Ser Cys Val Tyr 
                485                 490                 495     


Tyr Arg Ser Tyr Ala Pro Gly Glu Tyr Ile Tyr Leu Leu Leu Tyr Val 
            500                 505                 510         


Asp Asp Met Leu Ile Ala Cys Lys Ser Lys Ala Glu Ile Gly Ser Thr 
        515                 520                 525             


Lys Ser Leu Leu Lys Lys Glu Ile Asp Met Lys Glu Leu Gly Glu Ala 
    530                 535                 540                 


Lys Lys Ile Leu Gly Met Glu Ile Ile Arg Asp Arg Ser Arg Lys Ile 
545                 550                 555                 560 


Leu Arg Val Ser Gln Ser Gly Ile Asp Asn Gly Lys Ser Val Gln Met 
                565                 570                 575     


Pro Leu Gly Gly His Phe Lys Leu Ser Leu Lys Asp Cys Pro Val Arg 
            580                 585                 590         


Asp Cys Asp Val Glu Arg Met Ser Lys Val Pro Tyr Ser Asn Ala Val 
        595                 600                 605             


Gly Ser Leu Met Tyr Leu Met Val Cys Thr Arg Pro Asp Ile Ala Tyr 
    610                 615                 620                 


Ala Val Ser Val Val Ser Arg Tyr Leu Ala Asn Pro Gly Lys Asn His 
625                 630                 635                 640 


Trp Glu Ala Val Lys Trp Ile Leu Lys Tyr Leu Arg Gly Thr Ala Asn 
                645                 650                 655     


Val Gly Leu Val Phe Gly Thr Asn Arg Gly Asn His Val Asp Val Thr 
            660                 665                 670         


Gly Phe Val Asp Ser Asp Tyr Ala Lys Asp Pro Asp Lys Gly Arg Ser 
        675                 680                 685             


Ile Thr Gly Tyr Ala Phe Leu Val Gln Gly Cys Val Val Ser Trp Lys 
    690                 695                 700                 


Ala Thr Leu Gln His Val Val Ala Leu Ser Thr Thr Glu Ala Glu Tyr 
705                 710                 715                 720 


Met Ala Leu Thr Glu Ala Val Lys Glu Ala Ile Trp Leu Arg Gly Leu 
                725                 730                 735     


Leu Glu Glu Leu Gly Val Glu Leu Asn Thr Val Ala Val Asn Cys Asp 
            740                 745                 750         


Asn Gln Gly Ala Ile His Leu Ser Arg Asn His Val Phe His Glu Arg 
        755                 760                 765             


Thr Lys His Ile Asn Val Arg Tyr His Phe Ile Arg Asp Val Leu Glu 
    770                 775                 780                 


Ala Lys Thr Val Glu Val Leu Asn Ser Ser Arg Ser Arg Phe Gly Trp 
785                 790                 795                 800 


Leu Val Ser Gln Ala Gln Pro Val Ser Ser Phe Gln Pro Thr Tyr Arg 
                805                 810                 815     


Val Gly Val Leu Pro Pro His Leu Tyr Lys Arg Arg Cys Glu Gln Leu 
            820                 825                 830         


Met Ser Val Ala Lys Lys Phe Phe Asp Gln Gln Val Glu Glu Lys Arg 
        835                 840                 845             


Lys Val Met Arg Asn Glu Ala Asn Pro Leu Gly Tyr Cys Asp Thr Glu 
    850                 855                 860                 


Val Thr Lys Thr Val Arg Glu Trp Lys Glu Val Phe Asp Phe Thr Ala 
865                 870                 875                 880 


Gly Val Pro Met Val Met Pro Thr Glu Gly Asp Gln Thr Val Glu Tyr 
                885                 890                 895     


Ala Asn Gln Trp Pro Asp His Pro Ser Glu Leu Arg Glu Ala Cys Glu 
            900                 905                 910         


Glu Tyr Ala Lys Ala Val Gln Lys Leu Ser Ser Lys Leu Leu Lys Leu 
        915                 920                 925             


Ile Ser Met Ser Leu Asn Leu Ser Pro Asn Arg Leu Glu Pro Phe Phe 
    930                 935                 940                 


Lys Asp Gln Thr Ala Phe Val Arg Leu Asn His Tyr Pro Thr Cys Leu 
945                 950                 955                 960 


Ala Pro Asn Leu Ser Leu Gly Ala Gly Arg His Lys Asp Ala Gly Ala 
                965                 970                 975     


Leu Thr Ile Leu Ala Gln Asp Asp Val Gly Gly Leu Glu Val Lys Arg 
            980                 985                 990         


Lys Thr Tyr Gly Glu Trp Ile Phe  Val Lys Pro Val Arg  Asn Ser Phe 
        995                 1000                 1005             


Ile Ile  Asn Leu Gly Asp Val  Met Gln Val Trp Ser  Asn Asp Ile 
    1010                 1015                 1020             


Tyr Glu  Ser Ile Glu His Arg  Val Arg Val Asn Ser  Thr Arg Glu 
    1025                 1030                 1035             


Arg Phe  Ser Ile Pro Phe Phe  Met Asn Pro Ala Leu  Tyr Asn Val 
    1040                 1045                 1050             


Val Glu  Pro Leu Pro Glu Leu  Ile Ser Glu Glu Asn  Pro Ala Lys 
    1055                 1060                 1065             


Tyr Lys  Gly Tyr His Trp Gly  Lys Phe Leu Ala Thr  Gln Lys Gln 
    1070                 1075                 1080             


<210>  390
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  390

Met Ala Thr Ile Thr Ser Ser Ile Asn Ser Ser Tyr Asp Arg Ala Ala 
1               5                   10                  15      


Glu Val Lys Ala Phe Asp Glu Thr Lys Thr Gly Val Gln Gly Leu Val 
            20                  25                  30          


Asn Ala Gly Ile Gln Glu Ile Pro Arg Ile Phe Ile His Pro Pro Gln 
        35                  40                  45              


Asn Ile Pro Lys Thr Thr Ile Ser Phe Asp Ile Pro Val Ile Asp Leu 
    50                  55                  60                  


Ala Cys Thr Asp His Ala Ser Thr Leu Asp Lys Ile Leu Lys Ala Ser 
65                  70                  75                  80  


Glu Asn Leu Gly Phe Phe Gln Val Val Asn His Gly Ile Pro Thr Ser 
                85                  90                  95      


Ile Met Asn Glu Met Leu Gln Gly Val Arg Arg Phe His Glu Gln Asp 
            100                 105                 110         


Val Glu Val Lys Lys Lys Phe Tyr Thr Arg Asp Pro Ser Lys Ala Val 
        115                 120                 125             


Ile Tyr Asn Ser Asn Phe Asn Leu Tyr Ser Ser His Val Ala Asp Trp 
    130                 135                 140                 


Arg Asp Ser Phe Phe Ser Tyr Met Ala Pro Ser Pro Pro Leu Ala Glu 
145                 150                 155                 160 


Glu Leu Pro Glu Val Cys Arg Asp Ile Gln Ile Glu Tyr Ser Lys Gln 
                165                 170                 175     


Val Leu Lys Leu Gly Gly Leu Leu Phe Arg Leu Ile Ser Glu Ala Leu 
            180                 185                 190         


Gly Leu Glu Pro Thr His Leu Gly Asp Met Asp Cys Asp Lys Gly Met 
        195                 200                 205             


Leu Phe Leu Gly His Tyr Tyr Pro Ala Cys Pro Gln Pro Glu Leu Thr 
    210                 215                 220                 


Met Gly Ala Thr Lys His Thr Asp Asp Gly Leu Leu Thr Val Ile Leu 
225                 230                 235                 240 


Gln Asp Glu Thr Gly Gly Leu Gln Ile Leu Tyr Gln Asn Glu Trp Ile 
                245                 250                 255     


Asp Val Pro Ser Thr Pro Gly Ala Leu Val Ile Asn Ile Gly Asp Leu 
            260                 265                 270         


Leu Gln Leu Ile Ser Asn Asp Lys Leu Arg Ser Val Glu His Arg Val 
        275                 280                 285             


Val Ala Asn Gln Ile Gly Pro Arg Val Ser Ala Ala Cys Phe Phe Ser 
    290                 295                 300                 


Thr Asn Leu Ala Pro Ser Thr Lys Val Tyr Gly Pro Ile Lys Glu Leu 
305                 310                 315                 320 


Ile Thr Asp Asp Asn Pro Ala Arg Tyr Lys Glu Thr Thr Val His Asp 
                325                 330                 335     


Tyr Thr Asn Leu Ser Phe Ser Lys Gly Leu Gly Val Pro Gln Leu Leu 
            340                 345                 350         


Tyr Leu Lys Ile 
        355     


<210>  391
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  391

Met Asp Ile Ser Asn Ser Asn Asp Asp Arg Thr Lys Gln Leu Lys Ala 
1               5                   10                  15      


Phe Asp Asp Thr Lys Ser Gly Val Lys Gly Leu Leu Asp Ala Ala Ala 
            20                  25                  30          


Gly Gly Val Val Glu Ile Pro Gln Ile Phe Ile Arg Pro Pro Glu Glu 
        35                  40                  45              


Val Ala Glu Asp Leu Glu Leu Gly Arg Thr Ser Leu Arg Val Pro Ala 
    50                  55                  60                  


Ile Asp Leu Thr Gly Val Gly Asp Lys Gly Ser Cys Thr Arg Glu Lys 
65                  70                  75                  80  


Ile Val Glu Gln Val Lys His Ala Ser Glu Lys Trp Gly Phe Phe Gln 
                85                  90                  95      


Val Val Asn His Gly Val Pro Met Lys Val Leu Asp Ala Met Leu Asn 
            100                 105                 110         


Gly Ala Arg Glu Phe Asn Glu Gln Asp Val Glu Val Lys Lys Glu Tyr 
        115                 120                 125             


Tyr Ser Arg Asp Pro Glu Arg Met Val Lys Phe Asn Thr Asn Tyr Asp 
    130                 135                 140                 


Phe Tyr Met Ser Lys Ser Ala Ser Trp Arg Asp Thr Leu Ile Val Asp 
145                 150                 155                 160 


Met Leu Asn Ser Asn His Leu Asp Pro Gln Asp Leu Pro Ala Pro Cys 
                165                 170                 175     


Arg Asn Ser Thr Val Asp Tyr Leu Asn Gln Val Met Glu Leu Ala Asp 
            180                 185                 190         


Thr Leu Phe Glu Leu Leu Ser Glu Ala Leu Gly Leu Glu Pro Asn Tyr 
        195                 200                 205             


Leu Lys Gln Leu Glu Cys Glu Lys Ser Gln Thr Leu Thr Cys His Tyr 
    210                 215                 220                 


Tyr Pro Ala Cys Pro Lys Pro Asp Gln Thr Leu Gly Val Asn Lys His 
225                 230                 235                 240 


Thr Asp Ala Ser Phe Ile Ser Ile Leu Leu Gln Asp Glu Val Gly Gly 
                245                 250                 255     


Leu Gln Val Leu His Gln Asn Gln Trp Ala Asp Val Glu Pro Ile Pro 
            260                 265                 270         


Gly Ala Leu Val Val Asn Ile Gly Asp Leu Leu Gln Ile Val Ser Asn 
        275                 280                 285             


Asp Lys Phe Lys Ser Val Ile His Arg Ala Val Gly Asn Val Thr Gln 
    290                 295                 300                 


Ala Arg Thr Ser Val Ala Phe Phe Leu His Gly Val Val Thr Pro Pro 
305                 310                 315                 320 


Lys Met Tyr Gly Pro Ile Glu Lys Ile Ile Thr Lys Glu Ser Pro Arg 
                325                 330                 335     


Ile Tyr Arg Glu Phe Thr Val Lys Asp Tyr Met Met Lys Phe Tyr Ser 
            340                 345                 350         


Arg Gly Leu Asp Glu Lys Thr Gly Leu Asn Tyr Val Arg Ile 
        355                 360                 365     


<210>  392
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  392

Met Ser Gly Ala Ala Ala Asn Ser Asp Asp Ile Gly Gly Gly Ala Val 
1               5                   10                  15      


Glu Thr Val Ile Asn Ile Ser Ser Ser Ser Asp Leu Lys Leu Ile Lys 
            20                  25                  30          


Lys Asp Lys Asp Ser Arg Trp Phe Asp Val Glu Leu Val Pro Glu Ser 
        35                  40                  45              


Tyr Ile Phe Ser Pro Thr Asp Arg Pro Gln Asn Leu Asp Val Ala Ile 
    50                  55                  60                  


Cys Asp Ser Ile Pro Val Ile Asp Leu Ala Lys His Ile Gln Pro Ile 
65                  70                  75                  80  


Glu Ser Ile Leu Lys Ala Ser Gln Glu Phe Gly Phe Phe Gln Val Ile 
                85                  90                  95      


Asn His Gly Val Pro Glu Lys Ile Met Ser Asp Ala Met Ser Val Leu 
            100                 105                 110         


Lys Glu Phe Phe His Met Pro Ser Lys Glu Ala Thr Gly Glu Val Ile 
        115                 120                 125             


Ala Ala Tyr Leu Leu Glu Ile Asn Lys Leu Ser Phe Arg Ile Leu Glu 
    130                 135                 140                 


Met Ile Cys Glu Gly Leu Gly Leu Glu Pro Gly Tyr Leu Ser Asp Thr 
145                 150                 155                 160 


Ser Glu Val Gln Ile Leu Ser Ser Asn Phe Tyr Pro Ser Cys Pro Asp 
                165                 170                 175     


Pro Ser Leu Thr Leu Gly Ile Leu Ala His Gln Asp Thr Ser Leu Ile 
            180                 185                 190         


Thr Leu Val Tyr Gln Gly Asp Ser Thr Gly Leu Gln Phe Leu Lys Asp 
        195                 200                 205             


Gly Gln Trp Ile Asn Val Gly Ser Ile Pro Asn Ser Phe Val Val Asn 
    210                 215                 220                 


Ile Gly Asn Gln Leu Glu Ile Val Ser Asn Gly Lys Leu Arg Ser Ile 
225                 230                 235                 240 


Asp His Arg Val Val Thr Ser Lys Asp Lys Thr Arg Ile Ser Ile Ala 
                245                 250                 255     


Thr Phe Val Asn Pro Ser Tyr Asp Cys Ile Ile Glu Pro Ala Lys Ala 
            260                 265                 270         


Leu Val Asn Lys Asn Glu Pro Ser Arg Tyr Lys Ala Ser Arg Tyr Lys 
        275                 280                 285             


Glu Tyr Val Asp Arg Asn Lys Ala Phe Gly Asp Tyr Thr Val Ala Leu 
    290                 295                 300                 


Arg Asp Val Leu Asn Ser His Val Ile Arg Leu Glu Val Arg Glu Pro 
305                 310                 315                 320 


Ile Gly Gly Thr His Val Lys Thr Arg Arg Ile Gly Lys Val Glu Leu 
                325                 330                 335     


Asn Gly Gly Phe Trp Ile Ser Ala Val Val Val Cys Phe Ile Ile Leu 
            340                 345                 350         


Phe Glu Val Tyr Lys Lys Ala Ile Asp Pro Lys Ala Asp Gln Pro Glu 
        355                 360                 365             


Asn Asp Gly Val Lys Thr Arg Lys Asn Gly Lys Asn Lys Thr Lys Lys 
    370                 375                 380                 


Ile Gly Val Glu Val Asp Asp Glu Lys Pro Ile Asp Lys 
385                 390                 395         


<210>  393
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  393

Met Trp Leu Leu Leu Ala Ser Phe Ile Leu Arg Asn Lys Gln Leu Val 
1               5                   10                  15      


Phe Asn Pro Ile Ile Thr Leu Pro Ser Thr Phe Pro Phe His Leu Gln 
            20                  25                  30          


Asn His Ile His Asn Thr Met Val Leu Ser Ser Pro Ser Pro Leu Arg 
        35                  40                  45              


Thr Lys Lys Thr Arg Ala Ile Gly Ile Pro Ile Ile Asp Leu Ser Leu 
    50                  55                  60                  


Asp Thr Ala Thr Leu Ser Gln His Ile Val Thr Ala Cys Gln Glu Tyr 
65                  70                  75                  80  


Gly Phe Phe Lys Val Val Asn His Gly Val Pro Phe Glu Ile Ile Ser 
                85                  90                  95      


Lys Met Glu Glu Val Ala Gln His Phe Phe Ser Lys Pro Thr Ser Glu 
            100                 105                 110         


Lys Val Lys Val Gln Ala Asn Pro Pro Ser Pro Phe Gly Tyr Gly Cys 
        115                 120                 125             


Arg Asn Ile Gly Tyr Asn Gly Asp Val Gly Glu Leu Glu Tyr Leu Leu 
    130                 135                 140                 


Leu Gln Ala Asn Ser Ile Ala Leu Gly Ser Asp His Pro Thr Asn Phe 
145                 150                 155                 160 


Arg Gly Ala Val Glu Asp Tyr Ile Gln Ala Val Lys Gln Leu Thr Cys 
                165                 170                 175     


Gly Leu Leu Glu Ile Leu Ala Leu Gly Leu Ser Leu Pro Asp Thr Asn 
            180                 185                 190         


Ala Phe Ser Arg Phe Ile Gln Asp Val Asp Asn Asp Ser Cys Phe Arg 
        195                 200                 205             


Val Asn His Tyr Pro Gly Val Lys Ser Glu Ser Asn Gln Pro Lys Pro 
    210                 215                 220                 


Ala Gln Arg Ile Gly Phe Gly Glu His Ser Asp Pro Gln Ile Phe Thr 
225                 230                 235                 240 


Ile Leu Arg Ser Asn Asp Val Pro Gly Leu Gln Ile Ser Thr Phe Asp 
                245                 250                 255     


Gly Leu Trp Ile Pro Val Thr Asn Glu Pro Asn Asp Phe Cys Val Phe 
            260                 265                 270         


Val Gly Asp Ala Leu Glu Val Leu Thr Asn Gly Arg Phe Gln Ser Val 
        275                 280                 285             


Arg His Arg Val Met Ala Asn Met Ser Asn Lys Ser Arg Met Ser Met 
    290                 295                 300                 


Met Tyr Phe Ala Ala Pro Ala Leu Asn Glu Arg Leu Ser Pro Ile Pro 
305                 310                 315                 320 


Gln Met Ile Gly Asn Leu Arg Leu Tyr Lys Ser Phe Thr Trp Asn Glu 
                325                 330                 335     


Tyr Lys Lys Ala Ala Tyr Ser Leu Arg Leu Gly Asp Gln Arg Ile Asp 
            340                 345                 350         


Leu Phe Lys Cys His Ser Thr 
        355                 


<210>  394
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  394

Met Glu Ile Lys Lys Asp Lys Asp Ser Arg Trp Phe Asp Val Glu Leu 
1               5                   10                  15      


Val Pro Glu Ser Tyr Ile Phe Ser Pro Thr Asp Arg Pro Gln Asn Leu 
            20                  25                  30          


Asp Val Ala Ser Cys Asp Ser Ile Pro Val Ile Asn His Arg Val Pro 
        35                  40                  45              


Lys Lys Ile Met Ser Asp Ala Met Ser Val Leu Lys Glu Phe Phe Asp 
    50                  55                  60                  


Met Pro Ser Lys Glu Ala Thr Gly Tyr Val Pro Gln Asn Lys Gly Trp 
65                  70                  75                  80  


Ile Tyr Thr Asn Asn Asp Cys Thr Lys Asp Gly Val His Ile Trp Arg 
                85                  90                  95      


Glu Asn Leu Lys His Leu Cys His Pro Leu Asp Lys Cys Thr Lys Leu 
            100                 105                 110         


Trp Pro Asn Lys Pro Thr Arg Tyr Gln Glu Val Ile Ala Ala Tyr Leu 
        115                 120                 125             


Leu Glu Ile Asn Lys Leu Ser Leu Arg Ile Leu Glu Met Ile Cys Glu 
    130                 135                 140                 


Gly Leu Gly Leu Glu Pro Gly Tyr Leu Ser Asp Thr Ser Glu Val Gln 
145                 150                 155                 160 


Ile Leu Ser Ser Asn Phe Tyr Pro Ser Cys Pro Asp Pro Ser Leu Ile 
                165                 170                 175     


Leu Gly Ile Leu Ala His Gln Asp Thr Ser Leu Ile Thr Leu Val Tyr 
            180                 185                 190         


Gln Gly Asp Ser Pro Gly Leu Gln Phe Leu Lys Asp Gly Gln Trp Ile 
        195                 200                 205             


Asn Val Gly Ser Ile Pro Asn Ser Phe Val Val Asn Ile Gly Asn Gln 
    210                 215                 220                 


Leu Glu Ile Val Ser Asn Gly Lys Leu Arg Ser Ile Asp His Arg Val 
225                 230                 235                 240 


Val Thr Ser Lys Asp Lys Thr Arg Ile Ser Ile Ala Thr Phe Val Asn 
                245                 250                 255     


Pro Ser Tyr Ala Cys Ile Ile Glu Pro Ala Lys Ala Leu Val Asn Lys 
            260                 265                 270         


Asn Glu Pro Ser Arg Tyr Lys Ala Ser Arg Tyr Lys Glu Tyr Val Asp 
        275                 280                 285             


Arg Asn Lys Ala Phe Gly Asp Tyr Thr Val Ala Leu Arg Asp Val Val 
    290                 295                 300                 


Ile Ser Glu Ser 
305             


<210>  395
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  395

Met Ser Gly Ala Ala Ala Asn Ser Asp Asp Ile Gly Gly Gly Ala Val 
1               5                   10                  15      


Glu Thr Val Ile Asn Ile Ser Ser Ser Ser Asp Leu Lys Leu Ile Lys 
            20                  25                  30          


Lys Asp Lys Asp Ser Arg Trp Phe Asp Val Glu Leu Val Pro Glu Ser 
        35                  40                  45              


Tyr Ile Phe Ser Pro Thr Asp Arg Pro Gln Asn Leu Asp Val Ala Ile 
    50                  55                  60                  


Cys Asp Ser Ile Pro Val Ile Asp Leu Ala Lys His Ile Gln Pro Ile 
65                  70                  75                  80  


Glu Ser Ile Leu Lys Ala Ser Gln Glu Phe Gly Phe Phe Gln Val Ile 
                85                  90                  95      


Asn His Gly Val Pro Glu Lys Ile Met Ser Asp Ala Met Ser Val Leu 
            100                 105                 110         


Lys Glu Phe Phe His Met Pro Ser Lys Glu Ala Thr Gly Glu Val Ile 
        115                 120                 125             


Ala Ala Tyr Leu Leu Glu Ile Asn Lys Leu Ser Phe Arg Ile Leu Glu 
    130                 135                 140                 


Met Ile Cys Glu Gly Leu Gly Leu Glu Pro Gly Tyr Leu Ser Asp Thr 
145                 150                 155                 160 


Ser Glu Val Gln Ile Leu Ser Ser Asn Phe Tyr Pro Ser Cys Pro Asp 
                165                 170                 175     


Pro Ser Leu Thr Leu Gly Ile Leu Ala His Gln Asp Thr Ser Leu Ile 
            180                 185                 190         


Thr Leu Val Tyr Gln Gly Asp Ser Thr Gly Leu Gln Phe Leu Lys Asp 
        195                 200                 205             


Gly Gln Trp Ile Asn Val Gly Ser Ile Pro Asn Ser Phe Val Val Asn 
    210                 215                 220                 


Ile Gly Asn Gln Leu Glu Ile Val Ser Asn Gly Lys Leu Arg Ser Ile 
225                 230                 235                 240 


Asp His Arg Val Val Thr Ser Lys Asp Lys Thr Arg Ile Ser Ile Ala 
                245                 250                 255     


Thr Phe Val Asn Pro Ser Tyr Asp Cys Ile Ile Glu Pro Ala Lys Ala 
            260                 265                 270         


Leu Val Asn Lys Asn Glu Pro Ser Arg Tyr Lys Ala Ser Arg Tyr Lys 
        275                 280                 285             


Glu Tyr Val Asp Arg Asn Lys Ala Phe Gly Asp Tyr Thr Val Ala Leu 
    290                 295                 300                 


Arg Asp Val Leu Asn Ser His Val Ile Arg Leu Glu Val Arg Glu Pro 
305                 310                 315                 320 


Ile Gly Gly Thr His Val Lys Thr Arg Arg Ile Gly Lys Val Glu Leu 
                325                 330                 335     


Asn Gly Gly Phe Trp Ile Ser Ala Val Val Val Cys Phe Ile Ile Leu 
            340                 345                 350         


Phe Glu Val Tyr Lys Lys Ala Ile Asp Pro Lys Ala Asp Gln Pro Glu 
        355                 360                 365             


Asn Asp Gly Val Lys Thr Arg Lys Asn Gly Lys Asn Lys Thr Lys Lys 
    370                 375                 380                 


Ile Gly Val Glu Val Asp Asp Glu Lys Pro Ile Asp Lys Val Val Gly 
385                 390                 395                 400 


Glu Ser His Glu Val Gln Ala Cys Ala Glu Val Asn Asp Tyr Ser Leu 
                405                 410                 415     


Glu Asp Tyr Val Gly Leu Ser Pro Leu His Ser Met Thr Arg 
            420                 425                 430 


<210>  396
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  396

Met Ala Leu Leu Val Thr Ser Trp Ser Asn Gly Val Gln Ser Val Pro 
1               5                   10                  15      


Lys Asp Tyr Ile Met Pro Pro Glu Arg Arg Ala Gly Asp Phe Val Thr 
            20                  25                  30          


Ile Ser Lys Asp Ile Pro Val Ile Asn Leu Gln Asn Asp Arg Val Ile 
        35                  40                  45              


Asn His Gly Val Pro Asp Glu Met Met Ala Asp Met Arg Val Leu Tyr 
    50                  55                  60                  


Asp Glu Phe Phe Asn Met Pro Val Glu Asp Lys Leu Gly Val Tyr Ala 
65                  70                  75                  80  


Glu Lys Phe Gly Lys Gly Cys Thr Leu Tyr Thr Ser Gly Met Asn Tyr 
                85                  90                  95      


Ala Lys Glu Asp Val His Tyr Trp Lys Asp Thr Leu Lys His Pro Cys 
            100                 105                 110         


His Pro Leu Glu Glu His Thr Pro Ser Trp Pro Glu Lys Pro Thr Arg 
        115                 120                 125             


Tyr Arg Glu Glu Val Gly Lys Tyr Ser Ile Glu Val Arg Lys Met Gly 
    130                 135                 140                 


Phe Lys Ile Leu Glu Leu Ile Ala Glu Gly Leu Gly Leu Asn Lys Gly 
145                 150                 155                 160 


His Phe Glu Glu Val Gly Arg Glu Gln Ser Met Ala Ile Asn His Tyr 
                165                 170                 175     


Pro Pro Cys Pro Asp Pro Ser Leu Ala Met Gly Ile Gly Gly His Thr 
            180                 185                 190         


Asp Pro Asn Leu Ile Thr Phe Leu Gln Gln Asp His Tyr Gly Leu Gln 
        195                 200                 205             


Ile Gln Lys Asp Gly Gln Trp Met Gly Ile Glu Pro Ile Pro Asn Ala 
    210                 215                 220                 


Phe Val Val Asn Leu Gly Tyr Gln Leu Gln Ile Ile Ser Asn Gly Lys 
225                 230                 235                 240 


Leu Lys Ser Ala Glu His Arg Gly Val Leu Asn Ser Thr Ala Ser Arg 
                245                 250                 255     


Thr Ser Ile Val Thr Phe Phe Ala Pro Asn Pro Thr Leu Pro Leu Val 
            260                 265                 270         


Val Glu Pro Ala Lys Glu Leu Val Thr Ser Thr Thr Pro Gln Val Phe 
        275                 280                 285             


Lys Ser Tyr Leu Tyr Asn Glu Phe Leu Ala Glu Tyr Leu Ala Phe Ile 
    290                 295                 300                 


Arg Lys Pro Gly Pro Arg Asn Gly Thr Pro Leu Asp Pro Tyr Arg Ile 
305                 310                 315                 320 


<210>  397
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  397

Met Gly Ala Asn Ser Ile Asn Gly Asp Thr Ser Ile Pro Val Ile Asp 
1               5                   10                  15      


Leu Gln Asp Phe Pro Asn Gln Ser Ser Lys Leu Leu Ala Ala Cys Glu 
            20                  25                  30          


Glu Trp Gly Cys Phe Arg Leu Leu Asn Phe Asn Glu Ile Leu Pro Lys 
        35                  40                  45              


Thr Leu Met Leu Glu Met Gln Ala Val Ala Arg Ser Leu Cys Asp Leu 
    50                  55                  60                  


Pro Glu Glu Ile Lys Arg Arg Asn Ile Asp His Glu Val Pro Glu Asp 
65                  70                  75                  80  


Gly Tyr Ala Ala Pro Ser Pro Lys Tyr Pro Leu Tyr Glu Ala Ile Gly 
                85                  90                  95      


Met Gln Asp Leu Thr Ser Thr Arg Gly Val Asp Leu Phe Cys Ser Gln 
            100                 105                 110         


Leu Asp Ala Ala Pro Gln Gln Arg Glu Thr Ile Lys Lys Tyr Ala Glu 
        115                 120                 125             


Ala Ile Asp Gly Ile Ala Arg Glu Ile Val Lys Lys Met Gly Glu Ser 
    130                 135                 140                 


Leu Gly Val Lys Ser Glu Asn Leu Lys Phe Glu Asn Trp Lys Cys Lys 
145                 150                 155                 160 


Ser Arg Ile Asn Lys Tyr Gln Phe Thr Pro Gln Ser Phe Gly Ser Leu 
                165                 170                 175     


Gly Ala Pro Val His Thr Asp Ser Gly Ile Leu Thr Leu Val His Asp 
            180                 185                 190         


Asp Glu Glu Gly Val Gly Gly Leu Glu Ala Met Ser Pro Ser Gly Asp 
        195                 200                 205             


Phe Val Pro Phe Asp Pro Trp Pro Gly Thr Leu Ser Ile Leu Ile Ala 
    210                 215                 220                 


Asp Met Ala Thr Val Trp Ser Asn Gly Arg Phe Arg Asn Val Lys His 
225                 230                 235                 240 


Lys Ile Val Ser Lys Asp Gly Lys Ser Arg Val Ser Val Thr Ser Phe 
                245                 250                 255     


Val Thr Gly Leu Ala Glu Ile Leu Glu Pro Leu Pro Glu Leu Val Asp 
            260                 265                 270         


Asp His His Pro Arg Leu Phe Leu Pro Ile Asp Thr Glu Gly Tyr Arg 
        275                 280                 285             


Lys Leu Arg Tyr Ser Lys Asn Leu His Asp Gly Glu Ala Leu Ala Leu 
    290                 295                 300                 


Leu Gln Pro Asp His Ile Gln Thr 
305                 310         


<210>  398
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  398

Met Asn Phe Val Lys Ala Leu Ala Glu Ser Pro Asp Leu Asn Ser Val 
1               5                   10                  15      


Pro Ser Ile Tyr Asn Tyr Ser Thr Asn Ser Asn Glu Pro Leu Ala Ser 
            20                  25                  30          


Asp Pro Gln Glu Ser Ile Pro Thr Ile Asn Phe Ser Leu Leu Asn Ser 
        35                  40                  45              


Thr Asp Ala Asp Leu Arg Ser Lys Glu Ile Gln Glu Leu Asp Lys Ala 
    50                  55                  60                  


Cys Lys Glu Trp Gly Phe Phe Gln Val Ile Asn His Gly Val Pro Glu 
65                  70                  75                  80  


Ala Leu Met Lys Met Val Ile Glu Lys Ser Tyr Glu Phe Phe Asn Met 
                85                  90                  95      


Thr Asp Glu Glu Lys Lys Asp Phe Glu Glu Lys Asp Val Leu Asp Pro 
            100                 105                 110         


Ile Arg Tyr Gly Thr Ser Phe Asn Phe Lys Lys Asp Ile Val Leu Tyr 
        115                 120                 125             


Trp Arg Asp Phe Leu Lys Val Ile Val His Pro Glu Phe Asn Cys Pro 
    130                 135                 140                 


Asn Lys Pro Leu Gly Phe Ser Glu Val Leu Phe Glu Tyr Ser Gln Arg 
145                 150                 155                 160 


Thr Arg Glu Val Ala Arg Gly Leu Leu Asn Gly Ile Ser Leu Ser Leu 
                165                 170                 175     


Gly Leu Asp Gln Ser Tyr Ala Glu Lys Ala Leu Glu Phe Glu Ser Gly 
            180                 185                 190         


Leu Gln Ile Phe Val Val Asn Leu Tyr Pro Pro Cys Pro Gln Pro Glu 
        195                 200                 205             


Leu Ala Ile Gly Met Pro Pro His Ser Asp His Gly Leu Phe Thr Leu 
    210                 215                 220                 


Leu Ile Asn Asn Gly Val Ala Gly Leu Gln Ile Lys His Lys Gly Lys 
225                 230                 235                 240 


Trp Val Asn Val Asn Lys Thr Leu Pro Asn Ser Phe Leu Val Asn Thr 
                245                 250                 255     


Ala Asp Gln Leu Glu Ile Phe Ser Asn Gly Lys Tyr Arg Ser Val Glu 
            260                 265                 270         


His Arg Ala Val Val Asn Asn Ala Val Thr Arg Ile Ser Val Val Val 
        275                 280                 285             


Ala Asn Gly Pro Ala Leu Asp Thr Val Val Arg Pro Ala Tyr Lys Leu 
    290                 295                 300                 


Val Asp Glu Glu Thr Ser Pro Val Ala Tyr Val Pro Met Lys Tyr Lys 
305                 310                 315                 320 


Glu Tyr Leu Glu Met Gln Gln Gly Asn Gln Ile Val Gly Lys Lys Cys 
                325                 330                 335     


Leu Gln Arg Ile Gln Val 
            340         


<210>  399
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  399

Met Ala Thr Ile Thr Pro Leu Ile Thr Ser Ser Tyr Asp Arg Ala Ser 
1               5                   10                  15      


Glu Ile Lys Ala Phe Asp Glu Thr Lys Thr Gly Val Gln Gly Leu Val 
            20                  25                  30          


Asp Ala Ala Ile Gln Gln Ile Pro Arg Ile Phe Ile Asn Pro Pro Glu 
        35                  40                  45              


Pro Ile Pro Lys Ser Thr Thr Ser Phe Asp Ile Pro Leu Ile Asp Leu 
    50                  55                  60                  


Ala Ser Thr Asn Arg Ala Leu Ile Val Glu Ser Ile Arg Lys Ala Ser 
65                  70                  75                  80  


Glu Asn Leu Gly Phe Phe Gln Val Val Asn His Gly Ile Pro Ile Cys 
                85                  90                  95      


Ile Met Asn Glu Thr Leu Arg Gly Val Arg Arg Phe Tyr Glu Gln Asp 
            100                 105                 110         


Val Glu Val Lys Lys Gln Phe Tyr Thr Arg Asp Ala Ser Lys Ala Phe 
        115                 120                 125             


Val Tyr Asn Ser Asn Phe Asn Leu Tyr Ser Ser Pro Ala Ala Asn Trp 
    130                 135                 140                 


Arg Asp Thr Phe Phe Ser Phe Met Ala Pro Ser Pro Pro Lys Pro Glu 
145                 150                 155                 160 


Asp Leu Pro Val Val Cys Arg Asp Ile Gln Ile Asp Tyr Ser Ser Arg 
                165                 170                 175     


Val Leu Lys Leu Gly Glu Ser Leu Phe Gly Phe Ile Ser Glu Ala Leu 
            180                 185                 190         


Gly Leu Glu Thr His His Leu Gly Asp Met Glu Cys Asp Lys Gly Leu 
        195                 200                 205             


Thr Phe Val Ala His Ile Tyr Pro Ala Cys Pro Gln Pro Glu Leu Thr 
    210                 215                 220                 


Met Gly Ala Thr Lys His Thr Asp Ile Glu Phe Leu Thr Val Leu Leu 
225                 230                 235                 240 


Gln Asp Asp Ile Gly Gly Leu Glu Val Leu His Glu Asn Gln Trp Ile 
                245                 250                 255     


Asp Val Pro Pro Thr Pro Gly Ala Leu Val Ile Asn Ile Gly Asp Leu 
            260                 265                 270         


Leu Gln Met Ile Ser Asn Asp Lys Leu Arg Ser Val Glu His Arg Val 
        275                 280                 285             


Val Ala Asn Glu Lys Gly Pro Arg Val Ser Val Ala Cys Phe Phe Ser 
    290                 295                 300                 


Thr Ser Leu Ala Pro Ser Thr Lys Val Tyr Gly Pro Ile Lys Glu Leu 
305                 310                 315                 320 


Leu Ser Asp Asp Asn Pro Pro Gly Tyr Arg Glu Thr Thr Val Gln Asp 
                325                 330                 335     


Phe Val Glu Tyr Ser Phe Ser Lys Gly Pro Asp Gly Val Pro Arg Leu 
            340                 345                 350         


His Tyr Leu Lys Ile 
        355         


<210>  400
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  400

Met Gly Asn Leu Lys Asn Ser Gly Gly Ile Val Val Asp Ala Thr Val 
1               5                   10                  15      


Ser Gln Arg Gly Arg Arg Asp Trp Pro Glu Lys Gln Thr Glu Lys Met 
            20                  25                  30          


Glu Pro Asp Thr Ser Phe Lys Ser Val Met Ala Leu Ala Leu Glu Cys 
        35                  40                  45              


Gln Lys Asn Ile Pro Glu Gln Tyr Val Leu Pro Pro Leu Gln Arg Pro 
    50                  55                  60                  


Asn Met Ser Leu Thr Asp His Ile Pro Thr Ser Leu Pro Leu Ile Asp 
65                  70                  75                  80  


Leu Ser Met Ile Asn His Pro Ala His Arg Ser Gln Val Ile Asp Glu 
                85                  90                  95      


Val Arg Ala Ala Cys Lys Gln Leu Gly Phe Phe Gln Val Thr Asn His 
            100                 105                 110         


Gly Ile Pro Thr Ser Val Met Lys Asp Ala Leu Asp Thr Ala Glu Glu 
        115                 120                 125             


Phe Phe Asn Leu Pro Ser Glu Glu Lys Met Cys Phe Ala Ser Thr Asp 
    130                 135                 140                 


Val His Glu Pro Val Arg Tyr Gly Thr Ser Met Asn His Glu Lys Asp 
145                 150                 155                 160 


Lys Val Leu Tyr Trp Arg Asp Phe Leu Lys Leu Tyr Ala Tyr Pro Ile 
                165                 170                 175     


Ser Glu Trp Ile His Leu Trp Pro Ser Asn Pro Pro Ser Tyr Arg Glu 
            180                 185                 190         


Arg Met Gly Ser Tyr Ala Glu Ala Val His Lys Leu Gln Asn Gln Leu 
        195                 200                 205             


Met Glu Val Val Leu Glu Ser Leu Gly Leu Asn Ala Asn Tyr Leu His 
    210                 215                 220                 


Glu Asp Ile Glu Glu Gly Ser Gln Val Leu Ala Val Asn Cys Tyr Pro 
225                 230                 235                 240 


Ser Cys Pro Glu Pro Asp Leu Ala Leu Gly Met Pro Pro His Thr Asp 
                245                 250                 255     


Tyr Gly Thr Leu Thr Ile Leu Asn Gln Ser His Gln Gly Leu Glu Ile 
            260                 265                 270         


Met Asp His Ala Lys Lys Trp His Ser Val Pro Phe Ile Glu Gly Ala 
        275                 280                 285             


Leu Ile Val Gln Leu Gly Asp Gln Ser Glu Val Met Ser Asn Gly Arg 
    290                 295                 300                 


Tyr Lys Gly Thr Pro His Arg Ala Ile Leu Asn Val Gln Lys Lys Arg 
305                 310                 315                 320 


Leu Ser Ile Ser Ser Leu His Ser Phe Ala Ile Glu Lys Lys Ile Arg 
                325                 330                 335     


Pro Ala Pro Glu Leu Val Asp Glu Gln His Pro Val Ala Tyr Lys Glu 
            340                 345                 350         


Gly Ser Phe Ala Glu Phe Leu Asp Cys Ile Ala Leu Asn Ser Val Ser 
        355                 360                 365             


Asp Val Lys Tyr Ile Asp Thr Leu Arg Ile His 
    370                 375                 


<210>  401
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  401

Met Ala Asp Val Lys Gln Val Ser Lys Leu Asn Cys Ile Asp Leu Ser 
1               5                   10                  15      


Ser Pro Asp Thr Pro Thr Ser Val Ser Leu Leu Lys Gln Ala Cys Met 
            20                  25                  30          


Asp Ser Gly Phe Phe Tyr Val Thr Asn His Gly Ile Ser Pro Glu Phe 
        35                  40                  45              


Met Glu His Val Phe Thr Gln Ser Lys Asn Phe Phe Asp Leu Pro Leu 
    50                  55                  60                  


Asp Gln Lys Met Lys Leu Leu Arg Asn Glu Lys His Arg Gly Tyr Thr 
65                  70                  75                  80  


Pro Val Leu Asp Glu Leu Leu Asp Pro Val Asn Gln Leu His Gly Asp 
                85                  90                  95      


His Lys Glu Gly Phe Tyr Ile Gly Ile Glu Leu Pro Glu Asp Asp Pro 
            100                 105                 110         


Glu Ala Gln Arg Lys Phe Tyr Gly Pro Asn Leu Trp Pro Glu Ser Asp 
        115                 120                 125             


Ile Leu Pro Gly Trp Arg Gln Thr Met Glu Lys Tyr His Gln Met Ala 
    130                 135                 140                 


Met Glu Val Val Arg Lys Ile Ala Arg Leu Ile Ala Leu Ala Leu Asp 
145                 150                 155                 160 


Leu Glu Ala Asn Phe Phe Asp Arg Pro Glu Phe Leu Gly Arg Pro Ile 
                165                 170                 175     


Ala Val Leu Arg Leu Leu His Tyr Glu Gly Gln Val Ser Asp Pro Thr 
            180                 185                 190         


Lys Gly Met Tyr Gly Ala Gly Ala His Ser Asp Tyr Gly Leu Val Thr 
        195                 200                 205             


Leu Leu Ala Thr Asp Cys Val Ser Gly Leu Gln Ile Cys Lys Asp Lys 
    210                 215                 220                 


Asp Ala Lys Pro Gln Val Trp Glu Asp Val Lys Pro Leu Lys Gly Ala 
225                 230                 235                 240 


Phe Val Val Asn Leu Gly Asp Met Leu Glu Arg Trp Ser Asn Arg Ile 
                245                 250                 255     


Phe Arg Tyr Lys Tyr Ser Gly Leu Ser His Cys Phe Ala Val Ile Leu 
            260                 265                 270         


Val Phe Ile Trp Ser Ser Leu Asn Ile Cys Leu Asn Arg Ser Thr Leu 
        275                 280                 285             


His Arg Val Leu Gly Asn Gly Gln Glu Arg Tyr Ser Ile Pro Phe Phe 
    290                 295                 300                 


Val Glu Pro Ser His Asp Cys Val Val Glu Cys Leu Pro Thr Cys Gln 
305                 310                 315                 320 


Ser Lys Leu Asn Pro Pro Lys Phe Pro Pro Ile Lys Cys Glu Glu Tyr 
                325                 330                 335     


Leu Leu Gln Arg Tyr Gln Asp Thr His Ala Asp Leu Arg Thr Tyr Asn 
            340                 345                 350         


<210>  402
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  402

Met Lys Leu Pro Val Ile Asp Leu Ser Ser Ser Asp Arg Ile Ser Thr 
1               5                   10                  15      


Ala His Ser Ile Arg Gln Ala Cys Thr Asp Tyr Gly Phe Phe Tyr Leu 
            20                  25                  30          


Ile Asn His Gly Val Asp Glu Gln Thr Val Phe Glu Gln Ser Arg Leu 
        35                  40                  45              


Phe Phe Ser Leu Pro Leu Glu Asp Lys Met Lys Phe Ser Arg Asp Val 
    50                  55                  60                  


Ala Ala Asp Phe Gly Phe Ser Pro Leu Tyr Ala Glu Asn Leu Asp Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Lys Ala Lys Gly Asp Ser Lys Glu Ser Phe Arg 
                85                  90                  95      


Ile Gly Pro Leu Gln Asn Gln Arg Asn Gln Trp Pro Ser Gln Asp Leu 
            100                 105                 110         


Leu Pro Ser Trp Arg Ser Val Met Glu Thr Tyr Tyr Ala Ser Leu Leu 
        115                 120                 125             


Ser Ile Gly Lys Lys Leu Ser Ser Leu Ile Ala Leu Ala Leu Asn Leu 
    130                 135                 140                 


Asp Asp His Phe Phe His Ser Val Gly Ala Leu Asp Asn Pro His Thr 
145                 150                 155                 160 


Ile Leu Arg Leu Leu His Tyr Pro Gly Glu Met Gly Asp Ser Asp Glu 
                165                 170                 175     


Asp Gly Val Val Tyr Gly Ala Ser Ala His Ser Asp Tyr Gly Met Ile 
            180                 185                 190         


Thr Leu Leu Ala Thr Asp Gly Val Pro Gly Leu Gln Val Cys Arg Glu 
        195                 200                 205             


Lys Leu Lys His Pro Arg Thr Trp Glu Asn Val Asn His Val Lys Gly 
    210                 215                 220                 


Ala Phe Ile Val Asn Leu Gly Asp Leu Met Glu Arg Trp Thr Asn Cys 
225                 230                 235                 240 


Leu Phe Arg Ser Thr Leu His Arg Val Met Pro Thr Gly Lys Glu Arg 
                245                 250                 255     


Tyr Ser Met Ala Phe Phe Leu Asp Pro Asn Pro Asp Cys Gly Arg Met 
            260                 265                 270         


Leu Glu Lys Leu Leu Gln 
        275             


<210>  403
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  403

Met Ala Phe Ala Gln Pro Leu Met Ser His Glu Ser Val Gln Glu Leu 
1               5                   10                  15      


Ala Lys Glu His Asn Ile Thr Ile Pro Asp His Tyr Val Gln Glu His 
            20                  25                  30          


Pro Glu Pro Thr Phe Val Pro Asn Asp Cys Leu Pro Met Pro Ser Ile 
        35                  40                  45              


Pro Ile Ile Asp Met Asn Asp Leu Ile Met Gly Arg Leu Asn Met Asp 
    50                  55                  60                  


Leu His Leu Lys His Leu Arg Ser Val Cys His Glu Trp Gly Ile Phe 
65                  70                  75                  80  


Gln Leu Val Asn His Gly Val Asp Lys Ser Leu Val Glu Lys Met Lys 
                85                  90                  95      


Asn Glu Val Ile Glu Phe Phe Thr Leu Pro Ile Glu Glu Lys Leu Arg 
            100                 105                 110         


Tyr Lys Leu Lys Gly Gly Glu Tyr Glu Gly Tyr Gly Gln Thr Ile Leu 
        115                 120                 125             


His Ala Gln Gly Gln Lys Ile Asp Trp Ala Asp Arg Phe Tyr Met Ile 
    130                 135                 140                 


Thr Asn Pro Leu His Arg Arg Lys Ser Asn Leu Leu Pro Glu Phe Pro 
145                 150                 155                 160 


Pro Leu Leu Arg Asp Thr Leu Glu Asn Tyr Leu Leu Glu Leu Gln Lys 
                165                 170                 175     


Leu Gly Arg Thr Leu Phe Gly Ile Ile Gly Gln Ala Val Asp Ile Asp 
            180                 185                 190         


Lys Glu Glu Met Leu Glu Ile Phe Glu Asp Gly Met Gln Ser Val Arg 
        195                 200                 205             


Met Thr Tyr Tyr Pro Pro Cys Pro Gln Pro Asp Leu Val Val Gly Leu 
    210                 215                 220                 


Thr Pro His Ser Asp Ala Ala Gly Ile Thr Phe Leu Leu Gln Val Asn 
225                 230                 235                 240 


Asn Val Glu Gly Leu Gln Val Lys Lys Asp Gly Ala Trp Ile Pro Val 
                245                 250                 255     


Asn Phe Leu Pro Asp Ala Phe Val Val Asn Val Gly Asp Ile Leu Glu 
            260                 265                 270         


Ile Met Ser Asn Gly Val Tyr Thr Ser Ile Glu His Arg Ala Val Val 
        275                 280                 285             


Asn Ala Thr Lys Glu Arg Ile Ser Leu Ala Met Phe Phe Asn Pro Lys 
    290                 295                 300                 


Leu Glu Ala Asp Val Gly Pro Ser Lys Ser Leu Ile Lys Ser Thr Arg 
305                 310                 315                 320 


Asn Pro Pro Leu Tyr Lys Thr Leu Met Met Glu Gln Asp Lys Lys Leu 
                325                 330                 335     


Ala Pro Arg Leu Leu Ala Val Ser Val Thr Tyr Met Ile Ile Ser Arg 
            340                 345                 350         


<210>  404
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  404

Met His Lys Leu Pro Ser Ile Asp Phe Thr Asn Lys Lys Asn Leu Lys 
1               5                   10                  15      


Pro Ser Ser Thr Ser Trp Leu Ala Thr Ala Leu Glu Ala Thr Arg Ala 
            20                  25                  30          


Leu Glu Glu Tyr Gly Cys Phe Ile Ala Glu Phe Asp Lys Val Thr Pro 
        35                  40                  45              


Glu Leu Asn Asp Ala Val Phe His Gly Leu Glu Asp Leu Phe Asp Ile 
    50                  55                  60                  


Pro Ile Glu Thr Lys Val Leu Asn Lys Ser Thr Lys Pro Phe Glu Asn 
65                  70                  75                  80  


Val Leu Ala Tyr Asn Lys Leu Val Ala Glu Leu Glu Glu Met Val Thr 
                85                  90                  95      


Arg Met Val Phe Glu Thr Tyr Gly Val Glu Lys Tyr Leu Asp Ala His 
            100                 105                 110         


Arg Lys Met Val Thr Tyr Leu Cys Arg Gly Met Lys Tyr Arg Pro Pro 
        115                 120                 125             


Val Glu Asn Glu Thr Asn Met Gly Phe Val Pro His Thr Asp Lys Asp 
    130                 135                 140                 


Phe Ile Thr Val Leu His Gln Asn Gly Val Asn Gly Leu Glu Val Lys 
145                 150                 155                 160 


Ala Arg Asp Gly Glu Trp Phe Ser Val Glu Leu Val Pro Ser Ser Tyr 
                165                 170                 175     


Ile Val Met Ser Gly Asp Ala Ala Met Ala Trp Ser Asn Glu Arg Leu 
            180                 185                 190         


Tyr Ser Pro Phe His Arg Val Thr Met Asn Gly Lys Glu Ser Arg Tyr 
        195                 200                 205             


Ser Ile Ala Gln Phe Ser Phe Leu Glu Gly Ile Ile Glu Thr Pro Lys 
    210                 215                 220                 


Glu Phe Val Asp Glu Glu His Pro Leu Leu Tyr Lys Pro Phe Asp His 
225                 230                 235                 240 


Leu Lys Tyr Leu Asp Phe Tyr Asn Lys Glu Glu Asn Arg Arg Leu Glu 
                245                 250                 255     


Cys Ala Ile Arg Thr Tyr Cys Gly Val 
            260                 265 


<210>  405
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  405

Met Ala Ser Met Ser His Asp Phe His Arg Ala Lys Thr Glu Phe Asp 
1               5                   10                  15      


Gln Thr Lys Ala Gly Val Lys Gly Leu Leu Asp Ser Gly Val Val Lys 
            20                  25                  30          


Ile Pro Lys Ile Phe Val His Pro Thr Glu Asn Leu Val Lys Tyr Pro 
        35                  40                  45              


Ser Leu Gly Thr Cys Ser Leu Ser Leu Gln Val Pro Val Ile Asp Phe 
    50                  55                  60                  


Glu Ser Gly Lys Arg Ala Lys Ile Val Gly Glu Ile Lys Glu Ala Ser 
65                  70                  75                  80  


Glu Ser Trp Gly Ile Phe Gln Val Ile Asn His Gly Ile Ser Val Ser 
                85                  90                  95      


Val Leu Glu Glu Met Ile Lys Gly Val Gln Arg Phe His Glu Gln Arg 
            100                 105                 110         


Lys Glu Val Lys Met Glu Trp Tyr Ser Arg Glu His Asp Gln Arg Val 
        115                 120                 125             


Lys Phe Tyr Ser Asn Gly Asp Leu Tyr Val Ser Lys Ala Val Asn Trp 
    130                 135                 140                 


Arg Asp Ser Ile Ser Cys Tyr Tyr Ala Asp Gly Val Leu Asp Pro Asn 
145                 150                 155                 160 


Ala Leu Pro Gln Val Cys Arg Gly Ala Ile Glu Asn Tyr Met Glu Arg 
                165                 170                 175     


Ile Ile Lys Leu Lys Asp Thr Leu Ala Glu Leu Leu Ser Glu Ala Leu 
            180                 185                 190         


Gly Leu Asp Lys Asp Tyr Leu Thr Asn Leu Asp Cys Met Lys Thr Pro 
        195                 200                 205             


Thr Leu Val Cys His Tyr Tyr Pro Pro Cys Pro Glu Pro Asn Leu Thr 
    210                 215                 220                 


Leu Gly Ala Ala Lys His Ser Asp Pro Ser Phe Leu Thr Ile Leu Leu 
225                 230                 235                 240 


Gln Asp Ser Ile Gly Gly Leu Gln Val Leu Gln Arg Asn Gln Trp Val 
                245                 250                 255     


Asp Val Lys Pro Ile Lys Gly Ala Leu Ile Val Asn Ile Gly Asp Leu 
            260                 265                 270         


Met Gln Leu Ile Thr Asn Asp Lys Phe Lys Ser Val Glu His Arg Val 
        275                 280                 285             


Leu Ala Ala Pro Ile Gly Pro Arg Ile Ser Ala Ala Cys Phe Phe Tyr 
    290                 295                 300                 


Pro Ser Thr Ala Asn Asn Thr Lys Pro Tyr Gly Pro Ile Lys Glu Leu 
305                 310                 315                 320 


Leu Ser Glu Glu Cys Glu Pro Ile Tyr Arg Gln Thr Asn Tyr Lys Glu 
                325                 330                 335     


Tyr Met Thr His Tyr Lys Ala Lys Gly Leu Asp Gly Ala Ser Ser Leu 
            340                 345                 350         


Thr Leu Phe Lys Ala 
        355         


<210>  406
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  406

Met His Lys Leu Pro Ser Ile Asp Phe Thr Asn Lys Lys Asn Leu Lys 
1               5                   10                  15      


Pro Ser Ser Thr Ser Trp Leu Ala Thr Ala Leu Glu Ala Thr Arg Ala 
            20                  25                  30          


Leu Glu Glu Tyr Gly Cys Phe Ile Ala Glu Phe Asp Lys Val Thr Pro 
        35                  40                  45              


Glu Leu Asn Asp Ala Val Phe His Gly Leu Glu Asp Leu Phe Asp Ile 
    50                  55                  60                  


Pro Ile Glu Thr Lys Val Leu Asn Lys Ser Thr Lys Pro Phe Glu Asn 
65                  70                  75                  80  


Val Leu Ala Tyr Asn Lys Leu Val Ala Glu Leu Glu Glu Met Val Thr 
                85                  90                  95      


Arg Met Val Phe Glu Thr Tyr Gly Val Glu Lys Tyr Leu Asp Ala His 
            100                 105                 110         


Arg Lys Met Val Thr Tyr Leu Cys Arg Gly Met Lys Tyr Arg Pro Pro 
        115                 120                 125             


Val Glu Asn Glu Thr Asn Met Gly Phe Val Pro His Thr Asp Lys Asp 
    130                 135                 140                 


Phe Ile Thr Val Leu His Gln Asn Gly Val Asn Gly Leu Glu Val Lys 
145                 150                 155                 160 


Ala Arg Asp Gly Glu Trp Phe Ser Val Glu Leu Val Pro Ser Ser Tyr 
                165                 170                 175     


Ile Val Met Ser Gly Asp Ala Ala Met Ala Trp Ser Asn Glu Arg Leu 
            180                 185                 190         


Tyr Ser Pro Phe His Arg Val Thr Met Asn Gly Lys Glu Ser Arg Tyr 
        195                 200                 205             


Ser Ile Ala Gln Phe Ser Phe Leu Glu Gly Ile Ile Glu Thr Pro Lys 
    210                 215                 220                 


Glu Phe Val Asp Glu Glu His Pro Leu Leu Tyr Lys Pro Phe Asp His 
225                 230                 235                 240 


Leu Lys Tyr Leu Asp Phe Tyr Asn Lys Glu Glu Asn Arg Arg Leu Glu 
                245                 250                 255     


Cys Ala Ile Arg Thr Tyr Cys Gly Val Asn Val 
            260                 265         


<210>  407
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  407

Met Thr Thr Ser Thr Thr Arg Arg Glu Arg Glu Arg Glu Ser Arg Ala 
1               5                   10                  15      


Cys Gln Asn Leu Gly Ser Ser Ile Pro Val Pro Ser Val Lys Gln Leu 
            20                  25                  30          


Thr Ser Gln Pro Leu Glu Thr Val Pro His Arg Tyr Ile Gln Asp Thr 
        35                  40                  45              


Ser Asn Asp Tyr Pro Thr Ala Thr Pro Thr Pro Cys His Ser Leu Pro 
    50                  55                  60                  


Ile Ile Asp Phe Ser Lys Leu Ile His Pro Gln Tyr Gln Ser Ser Glu 
65                  70                  75                  80  


Leu Leu Asn Leu His Leu Ala Cys Lys His Trp Asp Gln Phe Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Gly Ile Thr Met Tyr Gln Arg Pro Phe Val Arg Gly 
            100                 105                 110         


Lys Leu Tyr Ile Arg Phe Thr Val Glu Phe Pro Glu Ser Phe Pro Lys 
        115                 120                 125             


Gln Cys Lys Ala Gln Gln Gly Val Leu Pro Pro Arg Pro Ser Met Gln 
    130                 135                 140                 


Met Thr Asp Met Glu Leu Asp Glu Cys Glu Glu Thr Thr Leu His Asp 
145                 150                 155                 160 


Val Asn Ile Glu Glu Glu Met Arg Arg Lys Gln Gln Glu Ala Leu Lys 
                165                 170                 175     


Met Lys Asn Asp Asp Met His Gly Glu Asp Thr Met Trp Thr Ala Ile 
            180                 185                 190         


Ser Val Gly Tyr Glu Leu Ile Gly His Arg Val Ser Glu Glu Ser Ile 
        195                 200                 205             


Lys Cys Met Asp Arg Lys Thr Gln Glu Phe Phe Asp Leu Ser Ser Glu 
    210                 215                 220                 


Glu Lys Lys Arg Tyr Ala Gln Lys Pro Gly Ser Leu Glu Gly Tyr Gly 
225                 230                 235                 240 


Gln Ala Phe Val Ile Ser Glu Asp Gln Lys Leu Glu Trp Cys Asp Met 
                245                 250                 255     


Ile Phe Leu Lys Ala Ile Pro Thr His Thr Arg Lys Leu Glu Phe Trp 
            260                 265                 270         


Pro Glu Glu Gln Pro His Asn Phe Arg Glu Ala Leu Asp Thr Tyr Ser 
        275                 280                 285             


His Asp Ile Lys Lys Thr Ala Val Ser Ile Ile Glu Phe Ile Ala Met 
    290                 295                 300                 


Ala Leu Gly Leu Asp Gly Lys Arg Phe Ser Glu Ala Phe Glu Gly Gly 
305                 310                 315                 320 


Asn Tyr Asp Val Arg Met Asn Cys Tyr Pro Pro Cys Pro Glu Pro Glu 
                325                 330                 335     


Arg Val Ile Gly Ile Ser Ser His Ala Asp Ile Ser Gly Ile Thr Leu 
            340                 345                 350         


Leu Thr Asp Cys Gly Asp Ile Pro Gly Leu Gln Val Leu Lys Asp Glu 
        355                 360                 365             


Lys Trp Val Phe Val Glu Pro Ile Thr Asn Gly Ile Val Val Asn Ile 
    370                 375                 380                 


Gly Ile Ile Met Glu Val Val Ser Asn Gly Val Tyr Lys Ala Pro Tyr 
385                 390                 395                 400 


His Arg Ala Ala Val Asn Lys Gln Lys Asp Arg Phe Ser Thr Val Thr 
                405                 410                 415     


Phe Cys Tyr Pro Gly Lys Lys Phe Asp Ile Lys Pro Ala Glu Glu Leu 
            420                 425                 430         


Ile Asn Ser Gly Ser Leu Ala Leu Tyr Lys Ser Phe Ser Tyr Asp Gly 
        435                 440                 445             


Tyr Phe Glu Ser Phe Tyr Glu Arg Thr Lys Leu Ser Gly Asp Gly Val 
    450                 455                 460                 


Pro Phe Ile Asp Thr Leu Lys Ile 
465                 470         


<210>  408
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  408

Met Ile Tyr Pro Tyr Ile Met Phe Arg Ser Thr Met Ala Arg Arg Asp 
1               5                   10                  15      


Ser Leu Pro Val Lys Thr Ala Gln Gln Met Ala Met Asp Gly Asp Gln 
            20                  25                  30          


Pro Pro Ser Lys Tyr Ile Tyr Ser Asn Asn Thr Ser Tyr Ala Lys Phe 
        35                  40                  45              


Gly Pro Leu Glu Thr Ser Pro Pro Phe Ala Pro Val Pro Val Ile Asp 
    50                  55                  60                  


Ile Gly Cys Leu Leu Ser Ser Cys Lys Gln Asp Glu Gln Glu Asn Glu 
65                  70                  75                  80  


Leu Ala Lys Leu Arg Ser Ala Leu Thr Thr Trp Gly Cys Phe Gln Ala 
                85                  90                  95      


Val Asn His Gly Leu Ser Asp Ser Tyr Leu Asp Asn Ile Gln Gln Val 
            100                 105                 110         


Ile Lys Gln Phe Phe Glu Leu Ser Leu Glu Asp Lys Arg Glu Tyr Phe 
        115                 120                 125             


Arg Glu Thr Gly Ser Val Glu Gly Tyr Gly Asn Asp Met Thr Tyr Ser 
    130                 135                 140                 


Glu Thr Gln Val Gln Asp Trp Cys Asp Arg Leu Phe Leu Arg Ile Leu 
145                 150                 155                 160 


Pro Glu Asp Gln Arg Lys Leu Arg Phe Trp Pro Glu Asn Pro Ser Asn 
                165                 170                 175     


Phe Arg Glu Thr Ile Asp Asp Tyr Thr Lys Lys Ile Met Ser Ile Ser 
            180                 185                 190         


Leu Val Ile Phe Lys Ala Met Ala Lys Ser Leu Glu Leu Glu Glu Asn 
        195                 200                 205             


Cys Phe Ser Lys His Phe Thr Glu Glu Ser Asp Val Leu Gln Gly Arg 
    210                 215                 220                 


Phe Ile Leu Tyr Pro Pro Cys Pro Thr Pro Asp Lys Val Phe Gly Leu 
225                 230                 235                 240 


Lys Ala His Ser Asp Arg Ser Gly Ile Thr Leu Leu Leu Gln Asp Pro 
                245                 250                 255     


Gly Val Glu Gly Leu Gln Val Leu Asn Asp Gly Lys Trp Tyr Met Val 
            260                 265                 270         


Pro Val Ile Pro Glu Ala Leu Phe Ile Asn Leu Gly Asp Gln Met Gln 
        275                 280                 285             


Ile Leu Ser Asn Gly Ile Phe Lys Ser Pro Val His Arg Val Val Thr 
    290                 295                 300                 


Asn Ser Asp Lys Gly Arg Ile Ser Val Ala Met Phe Thr Glu Pro Glu 
305                 310                 315                 320 


Pro Asn Lys Glu Ile Gly Pro Val Asp Ala Leu Val Asp Glu Lys Arg 
                325                 330                 335     


Pro Arg Val Tyr Lys Thr Val Lys Asp Tyr Ala Val Phe Asn His Glu 
            340                 345                 350         


Cys Phe Gln Lys Gly Val Val Ala Leu Asp Ala Val Lys Leu 
        355                 360                 365     


<210>  409
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  409

Met Ala Thr Ile Thr Ser Ser Ile Asn Ser Ser Tyr Asp Arg Ala Ser 
1               5                   10                  15      


Glu Val Lys Ala Phe Asp Glu Thr Lys Thr Gly Val Gln Gly Leu Val 
            20                  25                  30          


Asn Ala Gly Ile Gln Glu Ile Pro Arg Ile Phe Ile His Pro Pro Gln 
        35                  40                  45              


Thr Ile Pro Lys Ala Thr Val Ser Leu Asp Ile Pro Val Ile Asp Leu 
    50                  55                  60                  


Ala Cys Thr Asp His Ala Ser Thr Val Asp Lys Ile Leu Lys Ala Ser 
65                  70                  75                  80  


Glu Asn Leu Gly Phe Phe Gln Val Val Asn His Gly Ile Pro Ile Ser 
                85                  90                  95      


Ile Met Asn Glu Met Leu Gln Gly Val Arg Arg Phe His Glu Gln Asp 
            100                 105                 110         


Val Asp Val Lys Lys Lys Phe Tyr Thr Arg Asp Pro Ser Lys Ala Val 
        115                 120                 125             


Ile His Asn Ser Asn Phe Asp Leu Tyr Ser Thr Gln Ala Ala Asn Trp 
    130                 135                 140                 


Arg Asp Asn Phe Phe Ser Tyr Met Ala Pro Ser Pro Pro Ser Ala Glu 
145                 150                 155                 160 


Glu Leu Pro Glu Val Cys Arg Asp Ile Gln Ile Glu Tyr Ser Lys Gln 
                165                 170                 175     


Val Leu Lys Leu Gly Gly Leu Leu Phe Arg Leu Ile Ser Glu Ala Leu 
            180                 185                 190         


Gly Leu Glu Pro Asn His Leu Gly Asp Met Asp Cys Asp Lys Gly Ile 
        195                 200                 205             


Leu Ser Leu Gly His Tyr Tyr Pro Ala Cys Pro Gln Pro Glu Leu Thr 
    210                 215                 220                 


Met Gly Ala Thr Lys His Thr Asp Asp Gly Phe Leu Thr Val Leu Leu 
225                 230                 235                 240 


Gln Asp Glu Ile Gly Gly Leu Gln Ile Leu Tyr Gln Asn Lys Trp Ile 
                245                 250                 255     


Asp Val Pro Ser Thr Pro Gly Ala Ile Val Ile Asn Ile Gly Asp Leu 
            260                 265                 270         


Leu Gln Ala Ser Leu Leu Ile Ser Asn Gly Lys Leu Arg Ser Val Glu 
        275                 280                 285             


His Arg Val Val Ala Asn Gln Ile Gly Pro Arg Val Tyr Ala Ala Cys 
    290                 295                 300                 


Phe Phe Ser Thr Asn Leu Ala Pro Ser Ile Lys Val Tyr Gly Pro Ile 
305                 310                 315                 320 


Lys Glu Leu Val Ser Asp Asp Asn Pro Ala Arg Tyr Arg Glu Thr Thr 
                325                 330                 335     


Val His Asp Tyr Thr Lys Leu Thr Phe Ser Lys Gly Leu Gly Val Pro 
            340                 345                 350         


Arg Leu Leu Tyr Leu Lys Ile 
        355                 


<210>  410
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  410

Met Asn Phe Val Lys Ala Leu Ala Glu Ser Pro Asp Leu Asn Ser Val 
1               5                   10                  15      


Pro Ser Ile Tyr Asn Tyr Ser Thr Asn Ser Asn Glu Pro Leu Ala Ser 
            20                  25                  30          


Asp Pro Gln Glu Ser Ile Pro Thr Ile Asp Phe Ser Leu Leu Asn Ser 
        35                  40                  45              


Thr Asp Ala Asp Leu Arg Ser Gln Glu Ile Gln Glu Leu Asp Lys Ala 
    50                  55                  60                  


Cys Lys Glu Trp Gly Phe Phe Gln Val Ile Asn His Gly Val Pro Glu 
65                  70                  75                  80  


Ala Leu Met Lys Met Val Ile Glu Lys Ser Tyr Glu Phe Phe Asn Met 
                85                  90                  95      


Thr Asp Glu Glu Lys Lys Asp Phe Glu Glu Lys Asp Val Leu Asp Pro 
            100                 105                 110         


Ile Arg Tyr Gly Thr Ser Phe Asn Phe Lys Lys Asp Ile Val Leu Tyr 
        115                 120                 125             


Trp Arg Asp Phe Leu Lys Val Ile Val His Pro Glu Phe Asn Cys Pro 
    130                 135                 140                 


Asn Lys Pro Leu Gly Phe Ser Glu Val Leu Phe Glu Tyr Ser Gln Arg 
145                 150                 155                 160 


Thr Arg Glu Val Ala Arg Gly Leu Leu Asn Gly Ile Ser Leu Ser Leu 
                165                 170                 175     


Gly Leu Asp Gln Ser Tyr Ala Glu Lys Ala Leu Glu Phe Glu Ser Gly 
            180                 185                 190         


Leu Gln Ile Phe Val Val Asn Leu Tyr Pro Pro Cys Pro Gln Pro Glu 
        195                 200                 205             


Leu Ala Ile Gly Met Pro Pro His Ser Asp His Gly Leu Phe Thr Leu 
    210                 215                 220                 


Leu Ile Asn Asn Gly Val Ala Gly Leu Gln Ile Lys His Lys Gly Lys 
225                 230                 235                 240 


Trp Val Asn Val Asn Glu Thr Leu Pro Asn Ser Phe Leu Val Asn Thr 
                245                 250                 255     


Ala Asp Gln Leu Glu Ile Phe Ser Asn Gly Lys Tyr Arg Ser Val Glu 
            260                 265                 270         


His Arg Ala Val Val Asn Asn Ala Val Thr Arg Ile Ser Val Val Val 
        275                 280                 285             


Ala Asn Gly Pro Ala Leu Glu Thr Val Val Arg Pro Ala Tyr Lys Leu 
    290                 295                 300                 


Val Asp Glu Glu Met Cys Pro Val Ala Tyr Val Pro Met Lys Tyr Lys 
305                 310                 315                 320 


Glu Tyr Leu Glu Met Gln Gln Gly Asn Gln Ile Val Gly Lys Thr Cys 
                325                 330                 335     


Leu Gln Arg Ile Gln Val 
            340         


<210>  411
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  411

Met Ala Asp Cys Lys Lys Val Ser Lys Leu Asn Cys Ile Asp Leu Ser 
1               5                   10                  15      


Ser Gln Asp Ile Pro Thr Ser Val Ser Leu Leu Lys Gln Ala Cys Met 
            20                  25                  30          


Asp Ser Gly Phe Phe Tyr Val Thr Asn His Gly Ile Ser Glu Glu Phe 
        35                  40                  45              


Met Glu His Val Phe Thr Gln Ser Lys Asn Phe Phe His Leu Ser Leu 
    50                  55                  60                  


Asp Glu Lys Met Lys Leu Leu Arg Asn Glu Lys His Arg Gly Tyr Thr 
65                  70                  75                  80  


Pro Val Leu Asp Glu Thr Leu Asp Pro Ala Asn Gln Leu His Gly Asp 
                85                  90                  95      


His Lys Glu Gly Phe Tyr Ile Gly Ile Glu Leu Pro Glu Asp Asn Pro 
            100                 105                 110         


Asp Ala Gln Arg Thr Phe Tyr Gly Pro Asn Leu Trp Pro Asp Ser Asp 
        115                 120                 125             


Ile Leu Pro Gly Trp Arg Gln Thr Met Glu Lys Tyr His Gln Gln Ala 
    130                 135                 140                 


Leu Glu Val Gly Arg Lys Ile Ala Arg Leu Ile Ala Leu Ala Leu Asp 
145                 150                 155                 160 


Leu Asp Val Asn Phe Phe Asp Arg Pro Glu Ile Leu Gly Asn Pro Ile 
                165                 170                 175     


Ala Ile Leu Arg Leu Leu His Tyr Gly Gly Gln Val Ser Asp Pro Ala 
            180                 185                 190         


Lys Gly Ile Tyr Gly Ala Gly Ala His Ser Asp Phe Gly Phe Leu Thr 
        195                 200                 205             


Leu Leu Ala Thr Asp Asn Val Ser Gly Leu Gln Ile Cys Lys Asn Lys 
    210                 215                 220                 


Asp Ala Lys Pro Gln Val Trp Glu Asp Val Glu Pro Leu Lys Gly Ala 
225                 230                 235                 240 


Phe Val Val Asn Leu Gly Asp Met Leu Glu Arg Trp Ser Asn Cys Ile 
                245                 250                 255     


Phe Arg Ser Thr Leu His Arg Val Leu Gly Asn Gly Gln Gln Arg Tyr 
            260                 265                 270         


Ser Ile Pro Tyr Phe Val Glu Pro Ser His Asp Cys Val Val Glu Cys 
        275                 280                 285             


Leu Pro Thr Cys Gln Ser Val Gln Asn Pro Pro Lys Phe Pro Pro Val 
    290                 295                 300                 


Lys Tyr Glu Glu Tyr Leu Leu Gln Arg Tyr Arg Glu Thr His Ala Asp 
305                 310                 315                 320 


Leu Gly Thr Tyr Ser Lys His 
                325         


<210>  412
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  412

Met Ile Gln Ile Ala Lys Asn Tyr Phe Lys Leu Pro Glu Glu Glu His 
1               5                   10                  15      


Leu Lys Ser Tyr Ser Asp Asp Pro Asn Lys Thr Ile Arg Leu Ser Thr 
            20                  25                  30          


Ser Phe Asn Ile Arg Thr Glu Lys Val Lys Asn Trp Arg Asp Tyr Leu 
        35                  40                  45              


Arg Leu Gln Cys Tyr Pro Leu Glu Asp Tyr Val His Glu Trp Pro Glu 
    50                  55                  60                  


Asn Pro Glu Ser Phe Lys Glu His Val Ser Glu Tyr Cys Ala Ser Val 
65                  70                  75                  80  


Ser Gly Leu Ala Leu Glu Leu Ile Glu Ala Ile Ser Glu Ser Leu Gly 
                85                  90                  95      


Leu Gly Arg Asp Tyr Ile Ser Ala Gln Leu Gly Lys His Ala Gln His 
            100                 105                 110         


Ile Ala Leu Asn Tyr Tyr Pro Pro Cys Pro Gln Pro Asp Leu Thr Tyr 
        115                 120                 125             


Gly Leu Pro Gly His Ser Asp Leu Asn Leu Ile Thr Ile Leu Leu Gln 
    130                 135                 140                 


Ala Asp Glu Val Ser Gly Leu Gln Val Ser Lys Asp Gly Lys Trp Ile 
145                 150                 155                 160 


Ser Val Asp Pro Val Pro Asn Thr Phe Ile Ile Asn Val Gly Asp Gln 
                165                 170                 175     


Ile Gln Leu Gln Lys Lys Asp Tyr Phe Lys Leu Pro Glu Glu Glu His 
            180                 185                 190         


Leu Lys Ser Tyr Ser Asp Asp Pro Asn Lys Thr Ile Arg Leu Ser Thr 
        195                 200                 205             


Ser Phe Asn Ile Arg Thr Glu Lys Val Lys Asn Trp Arg Asp Tyr Leu 
    210                 215                 220                 


Arg Leu Gln Cys Tyr Pro Leu Glu Asp Tyr Val His Glu Trp Pro Glu 
225                 230                 235                 240 


Asn Pro Glu Ser Phe Lys Glu His Val Ser Glu Tyr Cys Ala Ser Val 
                245                 250                 255     


Ser Gly Leu Ala Arg Glu Leu Ile Glu Ala Ile Ser Glu Ser Leu Gly 
            260                 265                 270         


Leu Gly Arg Asp Tyr Ile Ser Glu Gln Leu Gly Lys His Ala Gln His 
        275                 280                 285             


Ile Ala Leu Asn Tyr Tyr Pro Pro Cys Pro Gln Pro Asp Leu Thr Tyr 
    290                 295                 300                 


Gly Leu Pro Gly His Ser Asp Leu Asn Leu Ile Thr Ile Leu Leu Gln 
305                 310                 315                 320 


Ala Asp Asp Val Ser Gly Leu Gln Val Ser Lys Asp Gly Lys Trp Ile 
                325                 330                 335     


Ser Val Asp Pro Val Pro Asn Thr Phe Ile Ile Asn Val Gly Asp Gln 
            340                 345                 350         


Ile Gln Val Leu Ser Asn Asp Lys Tyr Lys Ser Val Leu His Arg Ala 
        355                 360                 365             


Val Val Asn Cys Asp Lys Glu Arg Ile Ser Ile Pro Leu Phe Tyr Cys 
    370                 375                 380                 


Pro Ser Lys Asp Ala Ile Ile Glu Pro Ala Pro Met Leu Val Thr Asp 
385                 390                 395                 400 


Asp His Pro Ala Val Tyr Arg Gln Phe Lys Tyr Gly Glu Tyr His Glu 
                405                 410                 415     


Thr Phe Trp Asp Arg Gly Leu Ala Thr Glu Asn Cys Leu Asp Met Phe 
            420                 425                 430         


Met Ala Gly Leu Lys Ser Asp 
        435                 


<210>  413
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  413

Met Leu Pro Val Ile Asp Leu Ser Ser Ser Ser Glu Asp Arg Ile Ser 
1               5                   10                  15      


Thr Ala His Ser Ile Arg Gln Ala Cys Thr Asp Tyr Gly Phe Phe Tyr 
            20                  25                  30          


Leu Ile Asn His Gly Val Asp Glu Gln Leu Leu Gln Asn Val Phe Glu 
        35                  40                  45              


Gln Ser Arg Leu Phe Phe Ser Leu Pro Leu Glu Asp Lys Met Lys Cys 
    50                  55                  60                  


Ser Arg Asn Ile Gly Gly Asp Phe Gly Phe Ser Pro Leu Tyr Ala Glu 
65                  70                  75                  80  


Asn Leu Asp Ser Ser Ser Ser Ser Lys Thr Lys Gly Asp Ser Lys Glu 
                85                  90                  95      


Thr Phe His Ile Gly Pro Leu Gln Asn Gln Leu Asn Gln Trp Pro Ser 
            100                 105                 110         


Gln Asp Leu Leu Pro Ser Trp Arg Ser Val Met Glu Thr Tyr Tyr Thr 
        115                 120                 125             


Ser Leu Leu Ser Ile Gly Lys Lys Leu Ser Ser Leu Ile Ala Leu Ala 
    130                 135                 140                 


Leu Asn Leu Asp Asp His Phe Phe His Ser Ile Gly Ala Leu Asp Lys 
145                 150                 155                 160 


Pro Tyr Ala Phe Leu Arg Leu Leu His Tyr Pro Gly Glu Met Gly Asp 
                165                 170                 175     


Ser Asp Glu Asp Gly Val Val Tyr Gly Ala Ser Ala His Ser Asp Tyr 
            180                 185                 190         


Gly Met Ile Thr Leu Leu Ala Thr Asp Gly Val Pro Gly Leu Gln Val 
        195                 200                 205             


Cys Arg Glu Lys Leu Lys His Pro Arg Thr Trp Glu Asn Val Asn His 
    210                 215                 220                 


Val Lys Gly Ala Phe Ile Val Asn Leu Gly Asp Leu Met Glu Arg Trp 
225                 230                 235                 240 


Thr Asn Cys Leu Phe Arg Ser Thr Leu His Arg Val Met Pro Thr Gly 
                245                 250                 255     


Lys Glu Arg Tyr Ser Met Ala Phe Phe Leu Asp Pro Asn Pro Asp Cys 
            260                 265                 270         


Gly Arg Met Leu Glu Lys Leu Leu Gln 
        275                 280     


<210>  414
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  414

Met Ala Pro Ser Phe Asn Asp Glu Asn Ser Leu Phe Asn Phe Val Val 
1               5                   10                  15      


Lys Asp Gly Asn Gly Val Lys Gly Leu Val Asp Ser Gly Leu Thr Arg 
            20                  25                  30          


Val Pro Gly Gln Tyr Ile Gln Pro Pro Asn His Arg Ile Asn Lys Gln 
        35                  40                  45              


Asn Ala Thr Met Ser Leu Glu Asn Met Thr Ile Asp Leu Ser Glu Leu 
    50                  55                  60                  


Asp Gly Pro Asn His Asp Gln Val Val Lys Ser Ile Ala His Ala Ala 
65                  70                  75                  80  


Glu Thr Leu Gly Phe Phe Gln Val Val Asn His Gly Val Pro Leu Glu 
                85                  90                  95      


Leu Leu Glu Ser Leu Lys Met Ser Ala His Gln Phe Phe Asn Gln Pro 
            100                 105                 110         


Ser Glu Lys Lys Ala Val Tyr Leu Lys Gly Val Ser Pro Ser Pro Met 
        115                 120                 125             


Val Lys Tyr Gly Thr Ser Phe Val Pro Glu Lys Glu Lys Ala Leu Glu 
    130                 135                 140                 


Trp Lys Asp Tyr Ile Ser Met Ile Tyr Thr Asn Asp Ala Asp Ala Leu 
145                 150                 155                 160 


Glu Phe Trp Pro Asn Glu Cys Lys Leu Leu His Ala Leu Met Gly Asn 
                165                 170                 175     


Leu Gly Val Lys Leu Asp Asp Ser Ser Leu Asp Ala Leu Ile Gly Leu 
            180                 185                 190         


Arg Met Val Asn Met Asn Phe Tyr Pro Thr Cys Pro Asn Pro Asp Leu 
        195                 200                 205             


Thr Val Gly Val Gly Arg His Ser Asp Met Gly Met Leu Thr Val Leu 
    210                 215                 220                 


Leu Gln Asp Gly Ile Gly Gly Leu Tyr Val Lys Lys Gly Lys Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Lys Glu Asp Trp Ile Glu Ile Pro Pro Ile His Gly Ala 
                245                 250                 255     


Leu Val Ile Asn Ile Gly Asp Thr Leu Gln Ile Ile Ser Asn Gly Arg 
            260                 265                 270         


Tyr Lys Ser Ala Glu His Arg Val Arg Thr Thr Ser Val Glu Ser Arg 
        275                 280                 285             


Val Ser Val Pro Ile Phe Asn Ala Pro Leu Pro Met Val Lys Ile Gly 
    290                 295                 300                 


Pro Leu Pro Glu Val Val Ala Arg Asp Gly Val Ala Arg Tyr Arg Glu 
305                 310                 315                 320 


Val Ile Phe Glu Glu Glu Val Val Val Glu Tyr Ile Asn Ile Ser Lys 
                325                 330                 335     


Glu Leu Val Lys Arg Leu Leu Lys Ile Gly Ile Leu Gly Val Lys Leu 
            340                 345                 350         


Asp Asp Ser Lys Leu Asn Thr Leu Ile Gly Leu Arg Met Ile Asn Met 
        355                 360                 365             


Asn Phe Tyr Pro Thr Cys Pro Asn Gln Asp Leu Thr Val Gly Val Gly 
    370                 375                 380                 


Arg His Pro Asp Ile Gly Met Val Thr Ile Leu Pro Arg His Gly Ile 
385                 390                 395                 400 


Gly Gly Phe Tyr Val Lys Lys Pro Glu Asn Trp Ser Leu Gly Leu Asp 
                405                 410                 415     


Arg Asp Ser Thr Pro Glu Ala Leu Thr His Pro 
            420                 425         


<210>  415
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  415

Met Val Ile Pro Thr Asn Thr Arg Val Glu Thr Leu Ala Thr Ser Gly 
1               5                   10                  15      


Ile His Gln Ile Pro Lys Glu Tyr Ile Arg Thr Gln Asp Glu Leu Thr 
            20                  25                  30          


Thr Ile Thr Asn Ile Phe Asp Glu Glu Lys Lys Glu Leu Gly Pro Gln 
        35                  40                  45              


Val Pro Thr Ile Asp Leu Asn Asp Ile Asn Ser Lys Asp Pro Lys Thr 
    50                  55                  60                  


Arg Asp Lys Cys Cys Asn Glu Leu Val Lys Ala Ala Thr Glu Trp Gly 
65                  70                  75                  80  


Val Met His Ile Val Asn His Gly Ile Ser Ser Asp Leu Ile Asn Arg 
                85                  90                  95      


Val Lys Asp Ala Gly Glu Arg Phe Phe Asp Gln Pro Val Glu Glu Lys 
            100                 105                 110         


Glu Lys Tyr Ser Asn Asp Ile Ala Ser Gly Lys Met Gln Gly Tyr Gly 
        115                 120                 125             


Ser Lys Leu Ala Asn Asn Ala Cys Gly Gln Leu Glu Trp Glu Asp Tyr 
    130                 135                 140                 


Phe Phe His Leu Val Phe Pro Glu Glu Lys Arg Asp Leu Thr Val Trp 
145                 150                 155                 160 


Pro Ser Thr Pro Ser Asp Tyr Leu Pro Ala Thr Ala Glu Tyr Ala Arg 
                165                 170                 175     


Gln Leu Arg Ala Leu Thr Thr Lys Ile Leu Val Val Leu Ser Leu Gly 
            180                 185                 190         


Leu Gly Leu Glu Glu Gly Arg Leu Glu Asn Glu Val Gly Gly Leu Glu 
        195                 200                 205             


Glu Leu Ile Leu Gln Phe Lys Ile Asn Tyr Tyr Pro Lys Cys Pro Gln 
    210                 215                 220                 


Pro Glu Leu Ala Leu Gly Val Glu Ala His Thr Asp Val Ser Ala Leu 
225                 230                 235                 240 


Thr Phe Ile Leu His Asn Met Val Pro Gly Leu Gln Leu Phe Tyr Asp 
                245                 250                 255     


Gly Gln Trp Val Thr Ala Lys Cys Val Pro Asp Ser Ile Ile Met His 
            260                 265                 270         


Ile Gly Asp Thr Leu Glu Ile Leu Ser Asn Gly Lys Tyr Lys Ser Ile 
        275                 280                 285             


Leu His Arg Gly Leu Val Asn Lys Glu Lys Val Arg Ile Ser Trp Ala 
    290                 295                 300                 


Val Phe Cys Glu Pro Pro Lys Asp Lys Ile Ile Leu Lys Pro Leu Pro 
305                 310                 315                 320 


Glu Thr Ile Ser Lys Glu Asn Pro Pro Leu Phe Pro Pro Arg Thr Phe 
                325                 330                 335     


His Gln His Met Glu His Lys Leu Phe Lys Lys Lys Asp Asp Ser Val 
            340                 345                 350         


Glu Pro Lys 
        355 


<210>  416
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  416

Met Val Leu Asp Asn Thr Ser Leu Ser Gln Pro Asn Tyr Asp Arg Lys 
1               5                   10                  15      


Ala Glu Leu Lys Ala Phe Asp Glu Thr Lys Thr Gly Val Lys Gly Leu 
            20                  25                  30          


Val Asp Ala Gly Ile Thr Gln Val Pro Arg Ile Phe His Val Pro Ser 
        35                  40                  45              


Pro Gln Asn Leu Asn Ser Lys Gln Ser Cys Pro Lys Leu Ile Leu Pro 
    50                  55                  60                  


Thr Ile Asp Leu Glu Gly Ile Asn Glu Asp Ser Val Arg Arg Lys Glu 
65                  70                  75                  80  


Val Ile Gln Lys Val Asn Asp Ala Leu Lys Thr Trp Gly Phe Phe Gln 
                85                  90                  95      


Ile Val Asn His Gly Ile Ser Asn Ser Thr Leu Glu Glu Val Lys Lys 
            100                 105                 110         


Gly Val Arg Glu Phe Phe Glu Gln Asp Asp Glu Val Lys Lys Glu Trp 
        115                 120                 125             


Tyr Thr Arg Asp Met Ser Gly Lys Thr Arg Val Val Tyr Asn Ser Asn 
    130                 135                 140                 


Phe Asp Leu Tyr Ala Ala Pro Val Thr Asn Trp Arg Asp Thr Phe Phe 
145                 150                 155                 160 


Cys Met Met Ala Pro Tyr His Pro Glu Pro His Glu Leu Pro Gln Pro 
                165                 170                 175     


Cys Ser Asp Ile Leu Ser Lys Tyr Ser Ser Gln Val Leu Lys Leu Gly 
            180                 185                 190         


Gly Cys Val Phe Glu Leu Ile Ser Glu Ala Leu Gly Leu Asn Pro Asn 
        195                 200                 205             


His Leu Leu Asp Met Gly Cys Ala Glu Gly Leu Ala Val Leu Gly His 
    210                 215                 220                 


Tyr Tyr Pro Ser Cys Pro Gln Pro Glu Leu Ala Ile Gly Thr Thr Asn 
225                 230                 235                 240 


His Ala Asp Asn Ser Phe Ile Thr Ile Leu Leu Gln Asp His Val Gly 
                245                 250                 255     


Gly Leu Gln Val Phe Tyr Gln Glu His Trp Ile Asp Ile Pro Pro Ile 
            260                 265                 270         


Pro Gly Ala Leu Val Val Asn Ala Gly Asp Leu Leu Gln Leu Ile Thr 
        275                 280                 285             


Asn Asp Lys Phe Val Ser Ala Gln His Arg Val Leu Ala Asn Lys Ile 
    290                 295                 300                 


Gly Pro Arg Val Ser Val Ala Ser Phe Phe Thr Thr Ser Ser Ile Pro 
305                 310                 315                 320 


Thr Leu Lys Val Phe Glu Pro Ile Lys Glu Leu Leu Thr Glu Asp Asn 
                325                 330                 335     


Pro Pro Lys Tyr Arg Gly Thr Thr Val Lys Glu Tyr Val Asp Tyr Phe 
            340                 345                 350         


Asn Lys Lys Gly Leu Asp Glu Thr Ser Ala Leu Leu His Phe Lys Leu 
        355                 360                 365             


<210>  417
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  417

Met Ser Leu Asn Leu Ser Ala Asn Arg Leu Glu Pro Phe Phe Lys Asp 
1               5                   10                  15      


Gln Thr Ala Phe Val Arg Leu Asn His Tyr Pro Thr Cys Leu Ala Pro 
            20                  25                  30          


Asn Leu Ala Leu Gly Ala Gly Arg His Lys Asp Ala Gly Ala Leu Thr 
        35                  40                  45              


Ile Leu Ala Gln Asp Asp Val Gly Gly Leu Glu Val Lys Arg Lys Thr 
    50                  55                  60                  


Asp Gly Glu Trp Ile Phe Val Lys Pro Val Arg Asn Ser Phe Ile Ile 
65                  70                  75                  80  


Asn Leu Gly Asp Val Ile Gln Val Trp Ser Asn Asp Ile Tyr Glu Ser 
                85                  90                  95      


Ile Glu His Arg Val Arg Val Asn Ser Thr Arg Glu Arg Phe Ser Ile 
            100                 105                 110         


Pro Phe Phe Met Asn Pro Ala Leu Tyr Ile Val Val Glu Pro Leu Pro 
        115                 120                 125             


Glu Leu Ile Ser Glu Glu Asn Pro Ala Lys Tyr Lys Gly Tyr His Trp 
    130                 135                 140                 


Gly Lys Phe Leu Ala Thr Gln Lys Gln 
145                 150             


<210>  418
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  418

Met Ala Ser Leu Thr Thr Glu His Lys Tyr Asp Arg Leu Lys Glu Val 
1               5                   10                  15      


Lys Gln Phe Asp Glu Ser Gln Ile Gly Val Lys Gly Leu Leu Asp Thr 
            20                  25                  30          


Gly Ile Thr Thr Ile Pro Pro Phe Phe His Gln Pro Pro Glu Asn Leu 
        35                  40                  45              


Pro Ser Pro Gln Pro Lys Asn Gln Pro Arg Leu Thr Val Pro Val Ile 
    50                  55                  60                  


Asp Leu Ser Gln Asp Arg Ser Thr Val Val Asp Glu Ile Arg Gly Ala 
65                  70                  75                  80  


Ser Ser Ile Leu Gly Phe Phe Gln Ile Val Asn His Ser Ile Ser Val 
                85                  90                  95      


Thr Ser Ile Glu Ser Val Leu Lys Asp Met Lys Asn Phe Tyr Glu Gln 
            100                 105                 110         


Thr Thr Glu Tyr Lys Met Lys Phe Tyr Asn Arg Glu Val Glu Lys Gly 
        115                 120                 125             


Val Thr Tyr Ser Thr Asn Met Asp Leu Tyr Lys Ser Lys Ala Ala Ser 
    130                 135                 140                 


Trp Arg Asp Thr Ile Gln Val Trp Leu Ser Pro Met Glu Pro Ala Trp 
145                 150                 155                 160 


Lys Met Val Pro Glu Met Cys Arg Lys Ala Leu Ala Asp Trp Asp Lys 
                165                 170                 175     


Ala Ile Thr Gly Leu Val Glu Glu Leu Met Ser Ile Leu Cys Glu Gly 
            180                 185                 190         


Leu Gly Ile Lys Arg Asp Lys Leu Lys Glu Trp Ser Cys Leu Glu Gly 
        195                 200                 205             


Arg Leu Ser Ile Ser His Tyr Tyr Pro Gln Cys Pro Gln Pro Glu Leu 
    210                 215                 220                 


Thr Val Gly Leu Thr Ala His Thr Asp Pro Thr Val Leu Thr Val Leu 
225                 230                 235                 240 


Val Gln Asn Glu Ile Gly Gly Leu Leu Gln Val Lys Cys Gly Glu Gln 
                245                 250                 255     


Trp Val Glu Val Glu Pro Val Pro Gly Ala Ile Val Val Asn Ile Gly 
            260                 265                 270         


Asp Leu Leu Gln Met Met Ser Asn Asp Ile Tyr Arg Ser Val Glu His 
        275                 280                 285             


Arg Val Leu Ala Asn Asn Val Glu Gly Ala Arg Val Ser Val Ala His 
    290                 295                 300                 


Leu Phe Asn Pro Ser Asn Arg Glu Lys Leu Phe Gly Pro Phe Pro Glu 
305                 310                 315                 320 


Leu Ile Ser Ala Glu Lys Pro Ala Val Tyr His Glu Phe Leu His Glu 
                325                 330                 335     


Asp Phe Met Arg Arg Val Leu Ala Asn Asn Ile Glu Thr Ala Arg Val 
            340                 345                 350         


Ser Ile Ser Ala Phe Phe Ser Ile Gln Ala Thr Lys Arg Gly Asp Ile 
        355                 360                 365             


Tyr Gly Pro Phe Leu Glu Leu Lys Glu Cys Cys Lys Glu Ser Pro Val 
    370                 375                 380                 


Thr Ser His Asp Arg Cys Pro Ala Phe Gly His Leu Val Ala Ser Ser 
385                 390                 395                 400 


Val Ser Leu Phe Ser Thr Thr Asn Ile Leu Cys Ser Leu Gln Asn Leu 
                405                 410                 415     


Glu Asn Cys Ile Cys Asn Ile Tyr Lys Glu Ser Thr Leu Val Lys Asn 
            420                 425                 430         


Ser Asp Lys Tyr Phe Arg Trp Arg Phe Asn Leu Leu Gln Lys Asn Val 
        435                 440                 445             


Ser Met 
    450 


<210>  419
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  419

Met Val Val Ala Thr Gln Ile Asn Pro Ile His Val Glu Lys Asn Gln 
1               5                   10                  15      


Glu Met Thr Ile Pro Thr Ile Asp Leu Thr Gly Asp Glu Ser Lys Val 
            20                  25                  30          


Ser Lys Leu Ile Val Lys Ala Cys Glu Glu Tyr Gly Phe Phe Lys Val 
        35                  40                  45              


Ile Asn His Gly Val Asp Tyr His Ile Ile Lys Thr Ile Glu Asn Glu 
    50                  55                  60                  


Ser Phe Glu Phe Phe Asn Lys Pro Leu Val Glu Lys Gln Arg Ala Glu 
65                  70                  75                  80  


Leu Ala Lys Pro Phe Gly Tyr Gly Asn Lys Asn Ile Gly Leu Ser Gly 
                85                  90                  95      


Asp Thr Gly Glu Leu Glu Tyr Leu Leu Leu Gln Ala Asn Gln Asp Phe 
            100                 105                 110         


Ile Asp Asn Thr Ser Met Leu Ile Ser Asn Asp Pro Ser Ser Phe Ser 
        115                 120                 125             


Cys Arg Val Asn Ser Tyr Val Lys Ala Val Lys Gly Val Ala Cys Asn 
    130                 135                 140                 


Ile Leu Glu Leu Met Ala Lys Gly Ile Gly Gly Val Pro His Ser Val 
145                 150                 155                 160 


Phe Thr Thr Leu Leu Thr Glu Asp Asp Ser Asp Leu Leu Leu Arg Leu 
                165                 170                 175     


Asn His Tyr Pro Cys Val Thr His Pro Phe Gln His Asp Ala Asn Pro 
            180                 185                 190         


Ile Gly Phe Gly Glu His Ser Asp Pro Gln Ile Leu Thr Leu Leu Ala 
        195                 200                 205             


Ser Asn Gly Val Pro Gly Leu Gln Val Ser Leu Gly Asp Ser Arg Gln 
    210                 215                 220                 


Trp Leu Pro Val Thr Pro Asp Pro Arg Ala Phe Phe Val Ile Val Gly 
225                 230                 235                 240 


Asp Leu Leu Lys Ala Met Thr Asn Gly Arg Phe Ile Ser Val Arg His 
                245                 250                 255     


Arg Ala Met Ala Asn Thr Ser Thr Thr Glu Ser Arg Leu Ser Met Val 
            260                 265                 270         


Phe Phe Gly Gly Pro Pro Pro His Ala Thr Ile Thr Cys Pro Pro Lys 
        275                 280                 285             


Leu Val Lys Arg Asn Thr Pro Leu Val Tyr Lys Pro Phe Thr Trp Ala 
    290                 295                 300                 


Glu Tyr Lys Ser His Thr Tyr Ala His Arg Leu Gly Glu Ala Arg Leu 
305                 310                 315                 320 


Asp His Phe Lys Leu Ser 
                325     


<210>  420
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  420

Met Val Val Ala Thr Gln Ile Asn Pro Ile His Val Glu Lys Asn Gln 
1               5                   10                  15      


Glu Met Thr Ile Pro Thr Ile Asp Leu Thr Gly Asp Glu Ser Lys Val 
            20                  25                  30          


Ser Lys Leu Ile Val Lys Ala Cys Glu Glu Tyr Gly Phe Phe Lys Val 
        35                  40                  45              


Ile Asn His Gly Val Asp Tyr His Ile Ile Lys Thr Ile Glu Asn Glu 
    50                  55                  60                  


Ser Phe Glu Phe Phe Asn Lys Pro Leu Val Glu Lys Gln Arg Ala Glu 
65                  70                  75                  80  


Leu Ala Lys Pro Phe Gly Tyr Gly Asn Lys Asn Ile Gly Leu Ser Gly 
                85                  90                  95      


Asp Thr Gly Glu Leu Glu Tyr Leu Leu Leu Gln Ala Asn Gln Asp Phe 
            100                 105                 110         


Ile Asp Asn Thr Ser Met Leu Ile Ser Asn Asp Pro Ser Ser Phe Ser 
        115                 120                 125             


Cys Arg Val Asn Ser Tyr Val Lys Ala Val Lys Gly Val Ala Cys Asn 
    130                 135                 140                 


Ile Leu Glu Leu Met Ala Lys Gly Ile Gly Gly Val Pro His Ser Val 
145                 150                 155                 160 


Phe Thr Thr Leu Leu Thr Glu Asp Asp Ser Asp Leu Leu Leu Arg Leu 
                165                 170                 175     


Asn His Tyr Pro Cys Val Thr His Pro Phe Gln His Asp Ala Asn Pro 
            180                 185                 190         


Ile Gly Phe Gly Glu His Ser Asp Pro Gln Ile Leu Thr Leu Leu Ala 
        195                 200                 205             


Ser Asn Gly Val Pro Gly Leu Gln Val Ser Leu Gly Asp Ser Arg Gln 
    210                 215                 220                 


Trp Leu Thr Val Thr Pro Asp Pro Arg Ala Phe Phe Val Ile Val Gly 
225                 230                 235                 240 


Asp Leu Leu Lys Ala Met Thr Asn Gly Arg Phe Ile Ser Val Arg His 
                245                 250                 255     


Arg Ala Met Ala Asn Thr Ser Thr Thr Glu Ser Arg Leu Ser Met Val 
            260                 265                 270         


Phe Phe Gly Gly Pro Pro Pro His Ala Thr Ile Ala Cys Pro Pro Lys 
        275                 280                 285             


Leu Val Lys Arg Asn Thr Pro Leu Val Tyr Lys Pro Phe Thr Trp Ala 
    290                 295                 300                 


Glu Tyr Lys Ser His Thr Tyr Ala His Arg Leu Gly Glu Ala Arg Leu 
305                 310                 315                 320 


Asp His Phe Lys Leu Ser 
                325     


<210>  421
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (159)..(159)
<223>  Xaa can be any naturally occurring amino acid

<400>  421

Met Glu Asn Met Val Thr Lys Trp Cys Thr Thr Val Lys Ser Val Pro 
1               5                   10                  15      


Gln Asp Tyr Val Phe Pro Glu Gly Ile Arg Pro Gly Asp Gln Val Val 
            20                  25                  30          


Pro Ile Gly Lys Asn Phe Gln Val Ile Asp Leu Glu Asn Lys Ala Val 
        35                  40                  45              


Phe Gly Ser Gln Lys Asp Val Val Gln Gln Ile Ile Gln Ala Ser Gln 
    50                  55                  60                  


Asp Ser Gly Phe Phe Gln Val Ile Asn His Gly Ile Ser Glu Asp Leu 
65                  70                  75                  80  


Ile His Glu Ala Met Glu Val Ile Lys Glu Leu Tyr Asn Met Pro Asp 
                85                  90                  95      


Glu Asp Ile Ala Lys Ile Tyr Ser Leu Asp Pro Asn Lys Ser Cys Arg 
            100                 105                 110         


Leu Tyr Thr Ser Ser Phe Asn Tyr Val Asn Glu Ser Thr His Val Trp 
        115                 120                 125             


Arg Asp Asn Leu Lys His Pro Cys His Pro Leu Glu Asp Trp Val His 
    130                 135                 140                 


Leu Trp Pro Glu Lys Pro Ser Lys Tyr Arg Gln Met Ala Lys Xaa Tyr 
145                 150                 155                 160 


Pro Pro Cys Pro Glu Pro Gly Leu Thr Ile Gly Ile Ser Lys His Arg 
                165                 170                 175     


Asp Pro Asn Leu Leu Thr Ile Leu Tyr Gln Gly Asn Ala Ser Gly Leu 
            180                 185                 190         


Gln Val Leu Lys Asp Gly Gln Trp Tyr Gly Val Glu Pro Tyr Ala Asn 
        195                 200                 205             


Ala Phe Val Val Asn Ile Gly Gln Gln Leu Lys Val Ile Thr Asn Gly 
    210                 215                 220                 


Lys Phe Glu Ser Ser Glu His Arg Val Val Thr Asn Ser Lys Glu Ser 
225                 230                 235                 240 


Arg Tyr Thr Ile Ala Ser Phe Ile Asn Pro Gln Ser Asn Ala Val Ile 
                245                 250                 255     


Gly Pro Glu Lys Ser Leu Val Asp Lys Asp Asn Gly Arg Pro Leu Tyr 
            260                 265                 270         


Lys Pro Phe His Phe Lys Asp Phe Arg Leu Ser Phe Gln Glu His Met 
        275                 280                 285             


Gly Glu Gly Glu Ala Thr Ile Gly Met Phe Lys Ile Asp Gly 
    290                 295                 300         


<210>  422
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  422

Met Val Thr Met Gly Ala Pro Val Ile Asp Met Gln Lys Val Asp Gly 
1               5                   10                  15      


Leu Ala Glu Glu Leu Val Xaa Ile Ser Leu Leu Phe Gly Phe Leu Leu 
            20                  25                  30          


Ile Lys Glu Ile Ile Ser Lys Tyr Ile Lys Ser Ile Cys Asp Leu Asn 
        35                  40                  45              


Lys Phe Leu Gly Gln Lys Leu Met Glu Gly Cys Gly Leu Thr Gly Asp 
    50                  55                  60                  


Leu Phe Asp Gly Trp Cys Cys Gln Leu Arg Leu Asn Lys Tyr His Phe 
65                  70                  75                  80  


Cys Pro Glu Ser Ile Gly Leu Asn Gly Thr Pro Thr His Thr Asp Pro 
                85                  90                  95      


Ser Phe Leu Thr Ile Leu Gln Asp Asp Glu Asp Val Asn Gly Leu Gln 
            100                 105                 110         


Val Val Asp Lys Val Ser Gly Glu Phe Val Pro Phe Asp His Val Pro 
        115                 120                 125             


Gly Thr Leu Ala Ile Asn Ile Gly Asp Ile Gly Lys Val Trp Ser Asn 
    130                 135                 140                 


Gly Arg Phe Cys Ser Val Lys His Arg Val Leu Cys Phe Glu Pro Lys 
145                 150                 155                 160 


Thr Arg Tyr Ser Ile Ala Leu Phe Val Met Gly Pro Asn Asp Lys Ile 
                165                 170                 175     


Val Gln Ala Pro Ser Glu Leu Val Asp Ser Glu His Pro Arg Leu Tyr 
            180                 185                 190         


Val Pro Ile Asp Val Glu Lys Phe Arg His Val Arg Asn Thr Thr Gly 
        195                 200                 205             


Leu Arg Ala Gly Asp Ala Leu Asp Leu Phe Ser Thr Thr 
    210                 215                 220     


<210>  423
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  423

Met Asp Ile Leu Asn Asn Leu Arg Glu Asn Arg Thr Lys Gln Val Lys 
1               5                   10                  15      


Ala Phe Asp Asp Thr Lys Ser Gly Val Lys Gly Leu Ile Asp Ala Ala 
            20                  25                  30          


Ala Ser Gly Leu Val Asp Ile Pro Arg Ile Phe Ile Arg Pro Thr Asp 
        35                  40                  45              


Glu Leu Ala Glu Asp Leu Glu Leu Asn Arg Thr Ser Leu Gln Val Pro 
    50                  55                  60                  


Ala Ile Asp Leu Thr Gly Val Gly Asp Lys Gly Gly Ser Arg Arg Lys 
65                  70                  75                  80  


Ile Val Glu Glu Val Lys His Ala Ala Glu Asn Trp Gly Phe Phe Gln 
                85                  90                  95      


Val Val Asn His Gly Val Pro Ile Lys Val Leu Gln Asp Met Leu Asn 
            100                 105                 110         


Gly Val Arg Glu Phe His Glu Gln Asp Val Glu Ile Lys Lys Glu Tyr 
        115                 120                 125             


Tyr Ser Arg Asp Pro Glu Arg Met Val Lys Phe Asn Ser Asn Tyr Asp 
    130                 135                 140                 


Leu Tyr Met Ser Arg Ala Ala Asn Trp Arg Asp Thr Leu Ile Ile Asp 
145                 150                 155                 160 


Leu Leu Asn Thr Tyr His Leu Asp Pro Gln His Leu Pro Ser Val Cys 
                165                 170                 175     


Arg Glu Ser Thr Val Glu Tyr Leu Asn Tyr Leu Thr Lys Leu Val Asp 
            180                 185                 190         


Thr Leu Phe Glu Leu Leu Ser Glu Ala Leu Gly Leu Glu Pro Asn His 
        195                 200                 205             


Leu Lys Leu Leu Glu Cys Glu Lys Gly Arg Ser Leu Ala Cys His Tyr 
    210                 215                 220                 


Tyr Pro Ala Cys Pro Lys Pro Asp Gln Thr Leu Gly Leu Asn Lys His 
225                 230                 235                 240 


Thr Asp Ala Ser Phe Ile Thr Ile Leu Leu Gln Asp Glu Val Gln Gly 
                245                 250                 255     


Leu Gln Val Met His Gln Asn Gln Trp Ala Asp Val Glu Pro Ile Pro 
            260                 265                 270         


Gly Ala Leu Val Val Asn Ile Gly Asp Leu Leu Gln Ile Ile Ser Asn 
        275                 280                 285             


Asp Lys Phe Lys Ser Val Ile His Arg Val Phe Gly Asn Val Ala Leu 
    290                 295                 300                 


Thr Arg Thr Ser Val Ala Cys Phe Phe His Gly Val Ala Thr Pro Pro 
305                 310                 315                 320 


Lys Ile Tyr Gly Pro Ile Glu Lys Val Ile Thr Glu Glu Cys Pro Gln 
                325                 330                 335     


Met Phe Arg Glu Phe Thr Val Ile Asp Tyr Met Met Lys Phe Gln Ser 
            340                 345                 350         


Arg Gly Leu Asp Glu Lys Ser Gly Leu Asn Tyr Val Arg Leu 
        355                 360                 365     


<210>  424
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  424

Met Asp Ser Leu Glu Pro Leu Gln Ser Asn Glu Ser Leu Gln Glu Leu 
1               5                   10                  15      


Ala Arg Lys Leu Lys Leu Glu Val Pro Glu Arg Tyr Ile Gln Asp His 
            20                  25                  30          


Leu Glu Pro Thr Phe Val Ser Tyr Asp Ser Ser Pro Leu Pro Ser Ile 
        35                  40                  45              


Pro Val Ile Asp Met Asn Asp Leu Ile Lys Asn Leu Gly Ser Asp Met 
    50                  55                  60                  


Asp Gln Leu Lys Asn Leu Arg Ser Val Cys His Glu Trp Gly Ile Phe 
65                  70                  75                  80  


Gln Leu Val Asn His Gly Val Asp Lys Leu Leu Val Glu Asn Met Lys 
                85                  90                  95      


Lys Glu Met Thr Glu Phe Phe Lys Ile Pro Glu Glu Glu Lys Ser Arg 
            100                 105                 110         


Tyr Lys Leu Lys Ala Gly Glu Tyr Glu Gly Tyr Gly Gln Thr Leu Leu 
        115                 120                 125             


His Val Gln Asp Gln Lys Val Asp Trp Ala Asp Arg Phe Tyr Met Ile 
    130                 135                 140                 


Thr Asn Pro Leu His Arg Arg Lys Ser His Leu Leu Pro Asn Phe Pro 
145                 150                 155                 160 


Pro Ser Ile Arg Asp Thr Met Glu Thr Tyr Leu Gln Glu Leu Gln Lys 
                165                 170                 175     


Leu Ala Met Thr Leu Phe Gly Leu Ile Gly Gln Ala Ile Asp Ile Asp 
            180                 185                 190         


Lys Arg Glu Met Leu Asp Val Phe Glu Asp Gly Met Gln Ser Val Arg 
        195                 200                 205             


Met Thr Tyr Tyr Pro Pro Cys Pro Gln Pro Asp Leu Val Ile Gly Leu 
    210                 215                 220                 


Thr Pro His Ser Asp Ala Ser Gly Ile Thr Ile Leu Leu Gln Val Ser 
225                 230                 235                 240 


Asp Ile Glu Gly Leu Gln Val Lys Lys Asp Gly Thr Trp Ile Pro Val 
                245                 250                 255     


Asn Phe Leu Pro Asp Ala Phe Ile Ile Asn Met Gly Asp Ala Leu Glu 
            260                 265                 270         


Val Met Ser Asn Gly Val Tyr Asn Ser Ile Glu His Arg Val Met Val 
        275                 280                 285             


Asn Ala Thr Lys Glu Arg Ile Ser Leu Ala Met Phe Phe Asn Pro Lys 
    290                 295                 300                 


Leu Asp Ala Asp Val Gly Pro Ala Lys Ser Leu Leu Lys Asn Thr Gly 
305                 310                 315                 320 


Asn Pro Pro Ile Tyr Arg Thr Leu Val Met Glu Gln Tyr Leu Lys Glu 
                325                 330                 335     


Phe Phe Ser Ala Lys Leu Asn Gly Lys Thr Phe Leu Glu Lys Met Lys 
            340                 345                 350         


Ile Glu Ser Gly Glu Asn Ser Gly Thr 
        355                 360     


<210>  425
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  425

Met Ala Ser Val Val Ala Lys Thr Ser Ser Asn Ile Ser Gly Ser Thr 
1               5                   10                  15      


Thr Met Val Gln Glu Lys Gly Ser Arg Asn Lys Arg Lys Phe Arg Ala 
            20                  25                  30          


Asp Pro Pro Pro Ala Thr Glu Leu Lys Ser Glu Cys Leu Gly Tyr Glu 
        35                  40                  45              


Phe Ser Ala Glu Ser Phe Val Thr His Glu His Val Asn Gly Cys Asp 
    50                  55                  60                  


Met Cys Cys Phe Gly Arg Glu Ser Val Asp Pro Val Glu Leu Asp Leu 
65                  70                  75                  80  


Gly Leu Ser Cys Ser Val Gly Gly Thr Gly Gly Leu Ser Asn Gly Asn 
                85                  90                  95      


Arg Ala Glu Ile Glu Val Ser Asp Glu Phe His Asp Ala Asp Trp Ser 
            100                 105                 110         


Asp Leu Thr Glu Ser Gln Leu Glu Glu Leu Val Leu Ala Asn Leu Asp 
        115                 120                 125             


Thr Ile Phe Asn Leu Met Ile Leu Val Glu Asp Asn Asn Asn Trp Arg 
    130                 135                 140                 


Met Ile Leu Asp Asn Ser Asp Glu Val Gly Asn Asn Cys Ile Leu Val 
145                 150                 155                 160 


Phe Ser Leu Leu Asp Lys Pro Met Val Val Asp Asp Asn Ile Arg Phe 
                165                 170                 175     


Gly Val Ile Ile Phe Met Asn Ser Thr Lys Ile Tyr Asp Ile Ser Ser 
            180                 185                 190         


Ala Cys Arg Asp Trp Gly Ala Phe His Val Val Asn His Gly Val Glu 
        195                 200                 205             


Lys Lys Leu Leu Asp Glu Ile Arg Arg Asn Gly Leu Gly Phe Phe Glu 
    210                 215                 220                 


Glu Met Ser Met Glu Glu Lys Met Lys Tyr Gly Cys Glu Ala Gly Ser 
225                 230                 235                 240 


Ala Ala Ser Gln Gly Tyr Gly Asn Asp Ile Ser Ser Ala Cys Arg Asp 
                245                 250                 255     


Trp Gly Ala Phe His Val Val Asn His Gly Val Glu Lys Lys Leu Leu 
            260                 265                 270         


Asp Glu Ile Arg Arg Asn Gly Leu Gly Phe Phe Glu Glu Met Ser Met 
        275                 280                 285             


Glu Glu Lys Met Lys Tyr Gly Cys Glu Ala Gly Ser Ala Ala Ser Gln 
    290                 295                 300                 


Gly Tyr Gly Ser Lys Met Leu Val Ala Asp Gly Gly Asn Asp Gly Val 
305                 310                 315                 320 


Leu Asp Trp Arg Asp Tyr Phe Asp His His Thr Phe Pro Leu Ser Arg 
                325                 330                 335     


Arg Asp Pro Ser Arg Trp Pro His Phe Pro Asn Ser Tyr Arg Glu Val 
            340                 345                 350         


Val Ala Glu Tyr Ser Asp Gln Met Lys Ile Leu Ala Gln Lys Leu Leu 
        355                 360                 365             


Gly Leu Ile Ser Thr Ser Leu Gly Leu Ser Ser Ser Phe Ile Glu Asp 
    370                 375                 380                 


Ala Met Gly Glu Leu Tyr Gln Asn Ile Thr Ile Ser Tyr Tyr Pro Ser 
385                 390                 395                 400 


Cys Pro Gln Pro Glu Leu Thr Leu Gly Leu Gln Ser His Ser Asp Met 
                405                 410                 415     


Gly Phe Ile Thr Leu Leu Ile Gln Asp Asp Val Ala Gly Leu Gln Val 
            420                 425                 430         


Leu Lys Asp Asp Gln Trp Val Thr Val Asp Pro Val Ser His Ala Ile 
        435                 440                 445             


Leu Val Ile Leu Gly Asp Gln Thr Glu Ile Ile Thr Asn Gly Ile Tyr 
    450                 455                 460                 


Lys Ser Ser Val His Arg Ala Ile Thr Asn Ala Asn Lys Ala Arg Leu 
465                 470                 475                 480 


Ser Val Ala Thr Phe His Asp Pro Ala Lys Thr Thr Thr Val Ser Pro 
                485                 490                 495     


Ala Phe Lys Pro Pro Arg Tyr Asn Gln Val Val Tyr Gly Asp Tyr Val 
            500                 505                 510         


Lys Ser Trp Tyr Thr Lys Gly Pro Asn Glu Lys Gly Ser Arg Asn Lys 
        515                 520                 525             


Arg Lys Phe Arg Ala Asp Pro Pro Pro Ala Thr Glu Leu Lys Ser Glu 
    530                 535                 540                 


Cys Leu Gly Tyr Glu Phe Ser Ala Glu Ser Phe Val Thr His Glu His 
545                 550                 555                 560 


Val Asn Gly Cys Asp Met Cys Cys Phe Gly Arg Glu Ser Val Asp Pro 
                565                 570                 575     


Val Glu Leu Asp Leu Gly Leu Ser Cys Ser Val Gly Gly Thr Gly Gly 
            580                 585                 590         


Leu Ser Asn Gly Asn Arg Ala Glu Ile Glu Val Ser Asp Glu Phe His 
        595                 600                 605             


Asp Ala Asp Trp Ser Asp Leu Thr Glu Ser Gln Leu Glu Glu Leu Val 
    610                 615                 620                 


Leu Ala Asn Leu Asp Thr Ile Phe Lys Ser Ala Ile Lys Lys Ile Val 
625                 630                 635                 640 


Ser Phe Gly Tyr Thr Lys Asp Val Ala Thr Lys Ala Val Leu Arg Ser 
                645                 650                 655     


Gly Leu Cys Tyr Gly Cys Lys Asp Ala Val Ser Asn Ile Val Asn Asn 
            660                 665                 670         


Thr Leu Val Phe Leu Arg Asn Gly Gln Glu Val Asp Ser Leu Arg Glu 
        675                 680                 685             


His His Phe Glu Asp Leu His Gln Met Glu Lys Tyr Ile Leu Ala Glu 
    690                 695                 700                 


Leu Val Cys Val Val Arg Glu Val Arg Pro Phe Phe Ser Thr Gly Asp 
705                 710                 715                 720 


Ala Met Trp Cys Leu Leu Val Ser Asp Met Asn Val Ser His Ala Cys 
                725                 730                 735     


Thr Met Asp Ser Glu Ala Leu Ser Ser Leu Val Gly Asp Gly Pro Ser 
            740                 745                 750         


Asn Gly Cys Val Ser Asp Thr Asn Gly Ile Pro Gln Lys Ser Asn His 
        755                 760                 765             


Ser Ser Leu Cys Ala His Ser Ser Ser Leu Glu Pro His Val Thr Ser 
    770                 775                 780                 


Ser Ile Thr Pro Val Thr Pro Ser Lys Thr Glu Val Ser His Pro Lys 
785                 790                 795                 800 


Pro Lys Ala Pro Phe Val Leu Asn Lys Phe Ala Ser Glu Lys Glu Asn 
                805                 810                 815     


His Val Ser Thr His Arg Ile Val Ser Lys Ser Phe Ser Pro Ser Ser 
            820                 825                 830         


Gln Asn His Glu Glu Lys Val Gly Gly Arg Lys Ile Thr Gly Ile Asn 
        835                 840                 845             


Lys Arg Glu Ser Ile Leu Arg Gln Lys Ser Val His Leu Glu Lys Ser 
    850                 855                 860                 


Tyr Arg Thr Tyr Gly Ser Lys Gly Val Ser Arg Ser Gly Lys Leu Thr 
865                 870                 875                 880 


Asn Phe Gly Gly Leu Leu Leu Asp Lys Lys Leu Lys Ser Val Ser Glu 
                885                 890                 895     


Ser Thr Gly Ile Asn Leu Lys Asn Ile Ser Leu Lys Met Ser Lys Gly 
            900                 905                 910         


Ser Ile Thr Asp Asn Gly Pro Thr Gln Ile Gly Leu Ala Pro Ser Ala 
        915                 920                 925             


Val Phe Lys Thr Glu Ile Ile Asp Asn Ser Ile Ser Ala Leu Pro Lys 
    930                 935                 940                 


Lys Asn Thr Pro Val Ile Ser Pro Ser Val Asp Asn Pro Pro Val Leu 
945                 950                 955                 960 


Leu Ala Ser Glu Thr Glu Leu Ser Leu Ser His Pro Pro Lys Pro Asn 
                965                 970                 975     


Val Thr Pro Val Pro Glu Val Ser Thr Pro Ser Phe Ser Ala Lys Pro 
            980                 985                 990         


Tyr Asp Lys Ser Phe Gln Gln Arg  Ile Ser His Ala Lys  Lys Asp Glu 
        995                 1000                 1005             


Thr Ile  Met Lys Leu Val Pro  Arg Val His Glu Leu  Gln Asn Gln 
    1010                 1015                 1020             


Leu Gln  Glu Trp Thr Glu Trp  Ala Asn Gln Lys Val  Met Gln Ala 
    1025                 1030                 1035             


Ala Arg  Arg Leu Gly Lys Asp  Lys Ala Glu Leu Lys  Thr Leu Arg 
    1040                 1045                 1050             


Gln Glu  Lys Glu Glu Val Glu  Arg Leu Lys Lys Glu  Lys Gln Thr 
    1055                 1060                 1065             


Leu Glu  Asp Asn Thr Met Lys  Lys Leu Ser Glu Met  Glu Asn Ala 
    1070                 1075                 1080             


Leu Cys  Lys Ala Ser Gly Gln  Val Glu Arg Ala Asn  Ser Ala Val 
    1085                 1090                 1095             


Arg Gln  Leu Lys Val Glu Asn  Asn His Leu Arg His  Glu Met Glu 
    1100                 1105                 1110             


Ala Ala  Asn Val Arg Ala Ala  Glu Ser Ala Ala Ser  Cys Glu Glu 
    1115                 1120                 1125             


Val Ser  Lys Arg Glu Lys Lys  Thr Leu Met Gln Phe  Gln Ser Trp 
    1130                 1135                 1140             


Glu Lys  Leu Lys Ser Leu Phe  Gln Glu Glu Leu Ile  Ala Glu Lys 
    1145                 1150                 1155             


Arg Lys  Leu Thr Gln Leu Glu  Gln Asp Leu Glu Val  Ala Lys Glu 
    1160                 1165                 1170             


Gln Arg  Asp Gln Leu Glu Thr  Arg Trp Lys Gln Glu  Glu Lys Ala 
    1175                 1180                 1185             


Lys Glu  Asp Leu Val Ser Gln  Ala Thr Ser Tyr Arg  Ile Gly Arg 
    1190                 1195                 1200             


Leu Glu  Ala Glu Ser Ser Ala  Lys Leu Arg Glu Asp  Leu Thr Arg 
    1205                 1210                 1215             


Leu Lys  Ala Asp Lys Ser Leu  Gln Arg Tyr Lys Gln  Asp Ile Glu 
    1220                 1225                 1230             


Lys Leu  Glu Lys Glu Ile Ser  Leu Met Ser Leu Lys  Ser Asp Ser 
    1235                 1240                 1245             


Leu Lys  Ile Ala Ala Leu Arg  Gly Gly Ile Asp Gly  Ser Tyr Ala 
    1250                 1255                 1260             


Ser Lys  Leu Thr Asp Ile Lys  Thr Thr Pro Ser Gln  Gln Glu Ser 
    1265                 1270                 1275             


Gln Ala  Pro Leu Ile Pro Lys  Met Ala Asp Asn Phe  Tyr Gly Gly 
    1280                 1285                 1290             


Val Lys  Arg Glu Arg Glu Cys  Val Met Cys Leu Ser  Glu Glu Met 
    1295                 1300                 1305             


Ser Val  Val Phe Leu Pro Cys  Ala His Gln Val Val  Cys Lys Thr 
    1310                 1315                 1320             


Cys Asn  Glu Leu His Glu Lys  Gln Gly Met Lys Asp  Cys Pro Ser 
    1325                 1330                 1335             


Cys Arg  Gly Pro Ile Gln Arg  Arg Ile Cys Val Arg  Tyr Ala Arg 
    1340                 1345                 1350             


Ser 
    


<210>  426
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  426

Met Gln Thr Thr Pro Asp Tyr Glu Arg Lys Ala Glu Leu Lys Ala Phe 
1               5                   10                  15      


Asp Asp Thr Lys Lys Gly Val Lys Gly Leu Val Asp Ala Gly Ile Thr 
            20                  25                  30          


Asn Val Pro Arg Ile Phe His Val Pro Thr Pro Gln Asn Val Lys Asn 
        35                  40                  45              


Ser Ile Gln Pro Ser Leu Ser Gln Thr Cys Leu Pro Thr Ile Asn Leu 
    50                  55                  60                  


Lys Gly Ile Asn Lys Asp Met Ile Arg Arg Lys Glu Val Val Lys Glu 
65                  70                  75                  80  


Val Lys Asp Ala Leu Glu Thr Trp Gly Phe Phe Gln Met Val Asn His 
                85                  90                  95      


Gly Ile Pro Asn Ser Met Leu Glu Glu Val Lys Lys Gly Val Lys Ala 
            100                 105                 110         


Phe Phe Glu Gln Asp Asp Glu Val Lys Lys Gln Trp Tyr Thr Arg Gly 
        115                 120                 125             


Leu Asp Gly Gly Lys Arg Lys Val Val Tyr Asn Ser Asn Phe Asp Leu 
    130                 135                 140                 


Tyr Ala Ala Pro Val Thr Asn Trp Arg Asp Ser Ile Phe Cys Ile Met 
145                 150                 155                 160 


Ala Pro Asp Pro Pro Gln Ser His Glu Leu Pro Glu Pro Cys Arg Asp 
                165                 170                 175     


Ile Trp Pro Glu Tyr Ser Ser Gln Val Met Lys Leu Gly Ile Cys Val 
            180                 185                 190         


Leu Glu Leu Ile Ser Glu Ala Leu Glu Leu Asp Pro Asn Tyr Leu Leu 
        195                 200                 205             


Asp Met Gly Cys Ala Glu Gly Leu Gly Val Leu Ser Asn Tyr Tyr Pro 
    210                 215                 220                 


Ser Cys Pro Gln Pro Glu Leu Thr Ile Gly Ile Thr Asn His Ala Asp 
225                 230                 235                 240 


Ile Thr Phe Ile Thr Ile Leu Leu Gln Asp Gln Val Gly Gly Leu Gln 
                245                 250                 255     


Val Phe Tyr Gln Asp Gln Trp Thr Asp Val Pro Pro Ile Pro Gly Ala 
            260                 265                 270         


Leu Val Ile Asn Ala Gly Asp Leu Leu Gln Leu Ile Thr Asn Asp Lys 
        275                 280                 285             


Phe Val Ser Ala Gln His Lys Val Leu Ala Asn Lys Ile Gly Pro Arg 
    290                 295                 300                 


Val Ser Val Ala Ser Phe Phe Ser Thr Ser Thr Ile Pro Thr Asn Lys 
305                 310                 315                 320 


Val Phe Gly Pro Ile Lys Glu Leu Leu Ser Glu Asp Asn Pro Pro Lys 
                325                 330                 335     


Tyr Arg Gly Thr Thr Ile Lys Glu Tyr Val Glu Tyr Phe Thr Gly Lys 
            340                 345                 350         


Gly Leu Asp Gly Ile Ser Thr Leu Ser His Phe Lys Ile 
        355                 360                 365 


<210>  427
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  427

Met Pro Ser Gln Glu Lys Leu Pro Val Ile Thr Phe Asn Thr Gln Thr 
1               5                   10                  15      


Leu Asn Pro Ser Thr Asp Ala Trp Leu Ser Thr Ser Gln Ala Val Arg 
            20                  25                  30          


Arg Ala Leu Glu Asp Tyr Gly Cys Phe Val Val Ser Thr Asp Lys Ile 
        35                  40                  45              


Pro Ser Asp Leu His Asp Thr Ile Phe Glu Leu Ser Lys Asp Leu Phe 
    50                  55                  60                  


His Leu Pro Leu Glu Thr Lys Ile Lys Asn Thr Ser Asp Met Leu Gly 
65                  70                  75                  80  


Phe Gly Tyr Gly Asn Phe Ser Ser Tyr Pro Phe Trp Glu Tyr Phe Ser 
                85                  90                  95      


Ile Glu Tyr Gly Asp Thr Leu Glu Ala Asn Arg Ser Phe Thr Asp Leu 
            100                 105                 110         


Met Phe Pro Ser Gly Asn Asn Ala Phe Cys Glu Asn Ala Leu Lys Tyr 
        115                 120                 125             


Met Lys Ile Leu Ser Glu Ile Asp Gln Cys Val Met Arg Met Val Tyr 
    130                 135                 140                 


Asp Ser Tyr Gly Ile Asp Thr Lys Gln Cys Asp Gln Phe Ile Ala Ser 
145                 150                 155                 160 


Met Phe Tyr Leu Ala Arg Phe Ile Lys Tyr Arg Ala Pro Ser Glu Asp 
                165                 170                 175     


Lys Arg Ala Ile Ala Ile Asp His Pro Met Thr Glu Lys Asn Phe Ile 
            180                 185                 190         


Ser Ile Leu Gly Asp Asn Asn Val Lys Gly Leu Glu Ile Gln Met Arg 
        195                 200                 205             


Asn Gly Glu Trp Ile Tyr His Lys Pro Ser Pro Leu Thr Phe Val Val 
    210                 215                 220                 


Ile Ala Gly Glu Pro Phe Met Ala Trp Ser Asn Gly Arg Ile Tyr Ala 
225                 230                 235                 240 


Pro Met His Gln Val Ala Met Arg Thr Pro Glu Glu Glu Ala Thr Arg 
                245                 250                 255     


Tyr Thr Leu Gly Ile Phe Ser Phe Thr Arg Glu Thr Val Lys Val Pro 
            260                 265                 270         


Lys Glu Leu Val Glu Asp Ser Glu Asn Tyr Leu Arg Phe Lys Pro Phe 
        275                 280                 285             


Asn His Leu Asn Phe Leu Lys Tyr Val Ile Thr Glu Glu Leu Gln Gly 
    290                 295                 300                 


Tyr Lys Cys Ser Ile Glu Ser Tyr Cys Gly Val Thr Thr Thr Ala Pro 
305                 310                 315                 320 


Ala Lys Ala Asp Tyr 
                325 


<210>  428
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  428

Met Thr Ser Glu His Arg Tyr Asp Arg Leu Lys Glu Val Lys Glu Phe 
1               5                   10                  15      


Asp Ser Ser Lys Leu Ser Val Lys Gly Leu Leu Asp Thr Gly Ile Lys 
            20                  25                  30          


Thr Ile Pro Arg Phe Phe His Gln Pro Pro Glu Asn Leu Pro Ser Thr 
        35                  40                  45              


Gln Pro Lys Lys Lys Gln Pro Gln Leu Thr Val Pro Ile Ile Asp Met 
    50                  55                  60                  


Ser Gln Asp Arg Ser Lys Val Val Glu Glu Val Arg Arg Ser Ser Ser 
65                  70                  75                  80  


Thr Leu Gly Phe Phe Gln Ile Val Asn His Gly Val Pro Leu Ala Leu 
                85                  90                  95      


Ile Asp Cys Val Val Asn Ser Met Lys Ser Phe Tyr Glu Gln Pro Asn 
            100                 105                 110         


Glu Tyr Lys Met Lys Phe Tyr His Arg Glu Val Gly Lys Gly Ala Ser 
        115                 120                 125             


Tyr Ser Thr Asn Phe Asp Leu Phe His Ser Arg Gly Ala Ser Trp Arg 
    130                 135                 140                 


Asp Thr Phe Gln Val Arg Met Ser Pro Met Glu Pro Ala Trp Asp Leu 
145                 150                 155                 160 


Val Pro Glu Met Cys Arg Ala Ser Ile Ala Asp Trp Asp Lys Ala Val 
                165                 170                 175     


Val Asp Leu Ala Glu Glu Leu Met Ser Ile Leu Cys Glu Gly Leu Gly 
            180                 185                 190         


Ile Lys Ser Asp Lys Leu Lys Glu Leu Ser Cys Leu Glu Gly Arg Leu 
        195                 200                 205             


Cys Ala Ser His Tyr Tyr Pro His Cys Pro Gln Pro Glu Leu Thr Ile 
    210                 215                 220                 


Gly Ile Thr Ser His Thr Asp Pro Cys Ile Leu Thr Val Leu Val Gln 
225                 230                 235                 240 


Asn Glu Val Gly Asp Leu Leu Gln Val Lys Cys Gly Glu Glu Trp Ala 
                245                 250                 255     


Asp Val Glu Ala Val Pro Gly Ala Ile Val Ile Asn Ile Gly Asp Leu 
            260                 265                 270         


Leu Gln Met Met Ser Asn Asp Glu Tyr Lys Ser Val Glu His Arg Val 
        275                 280                 285             


Leu Ala Asn Pro Val Glu Gly Ala Arg Val Ser Val Ala Val Phe Phe 
    290                 295                 300                 


Lys Pro Ser Asn Gln Glu Gly Leu Tyr Ala Pro Phe Pro Glu Leu Ile 
305                 310                 315                 320 


Ser Ala Glu Lys Pro Ala Val Tyr Gln Glu Phe Leu Leu Ala Asp Tyr 
                325                 330                 335     


Thr Arg Arg Phe Tyr Ala Arg Glu Leu Asp Gly Lys Ala Leu Thr Ser 
            340                 345                 350         


Leu Tyr Arg Val Asp Asn Thr Lys Asp 
        355                 360     


<210>  429
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  429

Met Ile Val Val Gly Gln Val Trp Leu Ser Pro Met Glu Pro Ala Trp 
1               5                   10                  15      


Lys Met Val Pro Glu Met Cys Arg Lys Ala Leu Ala Asp Trp Asp Lys 
            20                  25                  30          


Ala Ile Thr Gly Leu Val Glu Glu Leu Met Ser Ile Leu Cys Glu Gly 
        35                  40                  45              


Leu Gly Ile Lys Arg Asp Lys Leu Lys Glu Trp Ser Cys Leu Glu Gly 
    50                  55                  60                  


Arg Leu Ser Ile Ser His Tyr Tyr Pro Gln Cys Pro Gln Pro Glu Leu 
65                  70                  75                  80  


Thr Val Gly Leu Thr Ala His Thr Asp Pro Thr Val Leu Thr Val Leu 
                85                  90                  95      


Val Gln Asn Glu Ile Gly Gly Leu Leu Gln Val Lys Cys Gly Glu Gln 
            100                 105                 110         


Trp Val Glu Val Glu Pro Val Pro Gly Ala Ile Val Val Asn Ile Gly 
        115                 120                 125             


Asp Leu Leu Gln Met Met Ser Asn Tyr Ile Tyr Arg Ser Val Glu His 
    130                 135                 140                 


Arg Val Leu Ala Asn Asn Val Glu Gly Ala Arg Val Ser Val Ala His 
145                 150                 155                 160 


Leu Phe Asn Pro Ser Asn Arg Glu Lys Leu Phe Gly Pro Phe Pro Glu 
                165                 170                 175     


Leu Ile Ser Ala Glu Lys Pro Ala Val Tyr His Glu Phe Leu His Glu 
            180                 185                 190         


Asp Phe Met Arg Arg Phe Leu Ser Lys Glu Ile Val Gly Lys Ser Lys 
        195                 200                 205             


Ile Asp Phe Tyr Arg Ile Asn Asn Thr Lys Asp Glu 
    210                 215                 220 


<210>  430
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  430

Met Glu Ser Gly Asp Cys Asp Glu Asn Lys Ala Phe Ser Ile Gly Glu 
1               5                   10                  15      


Pro Pro Gln Glu Asn Gly Leu Ser His Val Pro Arg Ser Tyr Glu Ile 
            20                  25                  30          


Ser Ser Ser Asn Arg Pro Ser Leu Asn Pro Glu Ile Ala Asn Val Ala 
        35                  40                  45              


Val Val Asp Leu Val Gly Leu Asn Asp Pro Asp Gln Arg Pro Met Val 
    50                  55                  60                  


Val Lys Asn Ile Gly Ser Ala Cys Arg Glu Ser Gly Phe Phe Gln Ile 
65                  70                  75                  80  


Ile Asn His Gly Ile Ser Gln Lys Val Leu Asp Glu Ala Leu Gly Thr 
                85                  90                  95      


Ala Phe Ala Phe Phe Asp Leu Pro Thr Thr Glu Lys Glu Lys Tyr Met 
            100                 105                 110         


Ser Asn Asp Val His Lys Pro Val Arg Tyr Gly Thr Ser Ile Lys Asp 
        115                 120                 125             


Glu Val Asp Lys Ile Gln Tyr Arg Arg Gly Phe Leu Lys His Tyr Ala 
    130                 135                 140                 


His Pro Leu Asn Glu Trp Ile Gln Glu Trp Pro Asp Lys Pro His Asp 
145                 150                 155                 160 


Tyr Arg Asp Lys Met Gly Ser Tyr Val Met Lys Ala Arg Arg Leu Ser 
                165                 170                 175     


Ile Glu Ile Met Gly Ala Ile Thr Glu Ser Leu Gly Ile Gly Arg Lys 
            180                 185                 190         


Tyr Leu Glu Asn Lys Met Glu Asp Gly Met Gln Val Met Ala Val Asn 
        195                 200                 205             


Cys Tyr Pro Lys Cys Pro Glu Pro His Leu Ala Leu Gly Val Pro Pro 
    210                 215                 220                 


His Ser Asp His Thr Cys Ile Thr Ile Val Leu Gln Ser Ser Cys Gly 
225                 230                 235                 240 


Leu Glu Ile Ile Asp Ala Ala Asp Gly Thr Trp Arg Leu Val Pro Glu 
                245                 250                 255     


Leu Gln Gly Ala Leu Glu Val His Val Gly Asp His Val Glu Val Leu 
            260                 265                 270         


Ser Asn Gly Leu Tyr Lys Ser Met Val His Arg Val Thr Leu Asn Asn 
        275                 280                 285             


Glu Arg Thr Arg Ile Ser Ile Val Ser Leu His Ser Met Gly Leu Asp 
    290                 295                 300                 


Glu Lys Met Ala Thr Ala Gln Glu Leu Val Ser Asp Glu Asn Pro Lys 
305                 310                 315                 320 


Lys Tyr Lys Glu Ser Ser Phe Arg Asp Phe Leu Asn Phe Leu Thr Arg 
                325                 330                 335     


Asn Glu Gly Lys Ser Tyr Ile Glu Ser Leu Lys Met 
            340                 345             


<210>  431
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  431

Met Ala Asp Lys Cys Thr Ile Pro Val Ile Asp Leu His Asn Leu Pro 
1               5                   10                  15      


Asn Gln Leu Pro Glu Leu Ile Ser Ala Cys Glu Asn Trp Gly Cys Phe 
            20                  25                  30          


Arg Leu Ile Asn His His Glu Ile Leu Ser Thr Lys Leu Met Leu Glu 
        35                  40                  45              


Met Lys Lys Val Val Arg Ser Leu Leu Asp Leu Pro Val Glu Ile Lys 
    50                  55                  60                  


Arg Arg Ser Ser Asp Ala Ile Ala Gly Ser Gly Tyr Met Ala Pro Ser 
65                  70                  75                  80  


Ala Lys Asn Pro Leu Tyr Glu Thr Leu Ala Leu Tyr Asp Met Ala Arg 
                85                  90                  95      


Ser Gly Asp Val Glu Arg Phe Cys Gln Glu Leu Asp Ala Thr His Asp 
            100                 105                 110         


Gln Arg Glu Ile Ile Met Arg Tyr Ala Glu Ala Val His Glu Leu Phe 
        115                 120                 125             


Met Arg Ile Ala Lys Lys Leu Ala Glu Gly Leu Gly Val Lys Arg Gly 
    130                 135                 140                 


Asp Ile Gly Phe Glu Asn Trp Pro Cys Glu Phe Arg Phe Asn Lys Tyr 
145                 150                 155                 160 


Asn Phe Ile Pro Glu Ser Val Gly Ser Pro Gly Val Gln Leu His Thr 
                165                 170                 175     


Asp Ser Ala Phe Leu Thr Ile Leu Gln Asp Asp Glu Ser Val Gly Gly 
            180                 185                 190         


Leu Glu Val Met Asp Lys Thr Gly Lys Phe Ile Thr Ile Asn Pro Trp 
        195                 200                 205             


Pro Asp Thr Leu Leu Val Asn Leu Gly Asp Met Ala Thr Val Arg Leu 
    210                 215                 220                 


<210>  432
<211>  908
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  432

Met Asp Gly Ser Asp Ile Tyr Lys Ala Ala Asn Ser Ile Arg Leu Gly 
1               5                   10                  15      


Ser Leu Arg Val Gly Ser Ser Ser Arg Ala Ser Ser Leu Arg Asn Gly 
            20                  25                  30          


Ser Thr Ser Val Trp Arg Asn Ser Gly Met Asp Ala Phe Ser Lys Ser 
        35                  40                  45              


Val Arg Glu Glu Asp Asp Glu Glu Ala Leu Lys Trp Ala Ser Leu Glu 
    50                  55                  60                  


Lys Leu Pro Thr Phe Asp Arg Leu Lys Lys Gly Leu Leu Phe Gly Ser 
65                  70                  75                  80  


Thr Gly Pro Ser Asn Glu Val Asp Val Asp Asn Leu Gly Pro Asp Asp 
                85                  90                  95      


Arg Arg Arg Ile Leu Asp Arg Leu Val Lys Thr Ala Asp Glu Asp Asn 
            100                 105                 110         


Glu Gly Phe Leu Leu Lys Leu Arg Asn Arg Leu Asp Arg Val Gly Ile 
        115                 120                 125             


Glu Leu Pro Thr Ile Glu Val Lys Tyr Glu His Val Thr Val Glu Ala 
    130                 135                 140                 


Asp Val Asn Thr Gly Ser Arg Ala Leu Pro Ser Phe Ile Asn Phe His 
145                 150                 155                 160 


Ile Glu Leu Val Glu Val Leu Leu Gly Leu Phe His Leu Leu Pro Asn 
                165                 170                 175     


Ser Lys Arg His Ile Thr Ile Leu Asp Asp Val Ser Gly Val Val Lys 
            180                 185                 190         


Pro Lys Arg Met Thr Leu Leu Leu Gly Pro Pro Ser Ser Gly Lys Thr 
        195                 200                 205             


Ser Leu Leu Leu Ala Met Ala Gly Thr Leu Ala Lys Glu Leu Lys Cys 
    210                 215                 220                 


Ser Gly Lys Val Thr Tyr Asn Gly His Glu Leu His Glu Phe Val Pro 
225                 230                 235                 240 


Glu Arg Thr Ser Ala Tyr Ile Ser Gln Asn Asp Val His Ile Gly Glu 
                245                 250                 255     


Met Thr Val Arg Glu Thr Leu Ala Phe Ser Ala Arg Cys Gln Gly Val 
            260                 265                 270         


Gly Ser Arg Tyr Asp Met Leu Ala Glu Leu Ser Arg Arg Glu Arg Asp 
        275                 280                 285             


Ala Asn Ile Lys Pro Asp Pro Asp Leu Asp Ile Phe Met Lys Ala Ala 
    290                 295                 300                 


Ala Thr Glu Gly Gln Glu Ala Asn Val Val Thr Asp Tyr Thr Leu Lys 
305                 310                 315                 320 


Leu Leu Gly Leu Asp Ile Cys Ala Asp Thr Met Val Gly Asp Gln Met 
                325                 330                 335     


Ile Arg Gly Ile Ser Gly Gly Gln Arg Lys Arg Val Thr Thr Gly Glu 
            340                 345                 350         


Met Ile Val Gly Pro Ser Lys Val Leu Leu Met Asp Glu Ile Ser Thr 
        355                 360                 365             


Gly Leu Asp Ser Ser Thr Thr Phe Gln Ile Val Lys Ser Leu Lys Gln 
    370                 375                 380                 


Phe Ile His Ile Leu Glu Gly Thr Ala Val Ile Ser Leu Leu Gln Pro 
385                 390                 395                 400 


Ala Pro Glu Thr Tyr Asp Leu Phe Asp Asp Ile Val Leu Leu Thr Asp 
                405                 410                 415     


Gly Lys Ile Val Tyr Gln Gly Pro Arg Glu His Val Leu Glu Phe Phe 
            420                 425                 430         


Glu Ser Val Gly Phe Lys Cys Pro Glu Arg Lys Gly Val Ala Asp Phe 
        435                 440                 445             


Leu Gln Glu Val Thr Ser Lys Lys Asp Gln Gln Gln Tyr Trp Met Arg 
    450                 455                 460                 


Arg Asp Met Pro Tyr Arg Phe Val Thr Ala Lys Glu Phe Ala Glu Ala 
465                 470                 475                 480 


Tyr Gln Ser Phe His Val Gly Arg Lys Leu Ala Thr Asp Leu Ala Thr 
                485                 490                 495     


Pro Tyr Asp Lys Ser Lys Ser His Pro Ala Ala Leu Thr Thr Glu Lys 
            500                 505                 510         


Tyr Gly Leu Asn Lys Lys Glu Leu Leu Lys Ala Cys Thr Asp Arg Glu 
        515                 520                 525             


Ile Leu Leu Met Lys Arg Asn Ser Phe Val Tyr Phe Phe Lys Leu Phe 
    530                 535                 540                 


Gln Leu Ile Val Met Ala Phe Ile Ser Met Thr Val Phe Phe Arg Thr 
545                 550                 555                 560 


Glu Met His Lys Arg Thr Leu Thr Asp Gly Gly Phe Tyr Asn Gly Ala 
                565                 570                 575     


Ala Phe Phe Gly Val Thr Leu Leu Met Phe Asn Gly Met Ser Glu Ile 
            580                 585                 590         


Ser Met Thr Ile Ala Lys Leu Pro Val Phe Tyr Lys Gln Arg Asn Phe 
        595                 600                 605             


Leu Phe Tyr Pro Ser Trp Ala Tyr Ala Ile Pro Ser Trp Ile Met Lys 
    610                 615                 620                 


Ile Pro Val Ser Phe Val Glu Ala Ala Val Trp Thr Ile Leu Thr Tyr 
625                 630                 635                 640 


Tyr Val Met Gly Phe Asp Pro Asn Val Thr Arg Phe Phe Lys Tyr Phe 
                645                 650                 655     


Phe Ile Leu Met Leu Val Asn Gln Met Ser Ser Gly Leu Phe Arg Phe 
            660                 665                 670         


Ile Gly Ala Leu Gly Arg Asn Met Ile Val Ala Asn Thr Phe Gly Ser 
        675                 680                 685             


Phe Gly Leu Leu Leu Val Phe Ala Leu Gly Gly Phe Ile Leu Ser Arg 
    690                 695                 700                 


Asp Asp Ile Lys Gly Trp Trp Ile Trp Gly Tyr Trp Ala Ser Pro Met 
705                 710                 715                 720 


Ile Glu Asn Val Leu Ala Tyr Asn Lys Leu Val Ala Glu Leu Glu Glu 
                725                 730                 735     


Met Val Thr Arg Met Val Phe Glu Thr Tyr Gly Val Glu Lys Tyr Leu 
            740                 745                 750         


Asp Ala His Arg Lys Met Val Thr Tyr Leu Cys Arg Gly Met Lys Tyr 
        755                 760                 765             


Arg Pro Pro Val Glu Asn Glu Thr Asn Met Gly Phe Val Pro His Thr 
    770                 775                 780                 


Asp Lys Asp Phe Ile Thr Val Leu His Gln Asn Gly Val Asn Gly Leu 
785                 790                 795                 800 


Glu Val Lys Ala Arg Asp Gly Glu Trp Phe Ser Val Glu Leu Val Pro 
                805                 810                 815     


Ser Ser Tyr Ile Val Met Ser Gly Asp Ala Ala Met Ala Trp Ser Asn 
            820                 825                 830         


Glu Arg Leu Tyr Ser Pro Phe His Arg Val Thr Met Asn Gly Lys Glu 
        835                 840                 845             


Ser Arg Tyr Ser Ile Ala Gln Phe Ser Phe Leu Glu Gly Ile Ile Glu 
    850                 855                 860                 


Thr Pro Lys Glu Phe Val Asp Glu Glu His Pro Leu Leu Tyr Lys Pro 
865                 870                 875                 880 


Phe Asp His Leu Lys Tyr Leu Asp Phe Tyr Asn Lys Glu Glu Asn Arg 
                885                 890                 895     


Arg Leu Glu Cys Ala Ile Arg Thr Tyr Cys Gly Val 
            900                 905             


<210>  433
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  433

Met Val Leu Asp Ser Thr Ser Thr Ile Gln Pro Asp Tyr Asp Arg Lys 
1               5                   10                  15      


Ala Glu Leu Ile Ala Phe Asp Glu Thr Lys Thr Gly Val Lys Gly Leu 
            20                  25                  30          


Val Asp Ala Gly Ile Thr Gln Val Pro Arg Ile Phe His Val Pro Ser 
        35                  40                  45              


Pro Gln Ile Leu Arg Asn Ser Val Glu Pro Ser Phe Ser Lys Pro Ser 
    50                  55                  60                  


Leu Pro Thr Ile Asp Leu Glu Gly Ile Asp Glu Asp Pro Lys Arg Arg 
65                  70                  75                  80  


Lys Glu Val Ile Lys Glu Val Lys Asp Ala Leu Glu Thr Trp Gly Phe 
                85                  90                  95      


Phe Gln Met Val Asn His Gly Ile Pro Asn Ser Met Leu Glu Glu Val 
            100                 105                 110         


Lys Lys Ala Val Lys Gly Phe Phe Glu Gln Asp Asp Glu Val Lys Lys 
        115                 120                 125             


Gln Trp Tyr Thr Arg Asp Phe Ser Gly Lys Arg Lys Val Val Tyr Asn 
    130                 135                 140                 


Ser Asn Phe Asp Leu Tyr Thr Gly Thr Val Thr Asn Trp Arg Asp Ser 
145                 150                 155                 160 


Phe Phe Cys Pro Met Ala Pro Asn Pro Pro Gln Pro His Glu Leu Pro 
                165                 170                 175     


His Pro Cys Arg Asp Ile Trp Pro Glu Tyr Ser Ser Gln Val Met Lys 
            180                 185                 190         


Leu Gly Ile Phe Met Leu Glu Ile Ile Ser Glu Ala Leu Gly Leu Asp 
        195                 200                 205             


Ser Asn His Leu Leu Asp Met Gly Cys Ala Glu Gly Leu Cys Leu Leu 
    210                 215                 220                 


Ala Asn Tyr Tyr Pro Ser Cys Pro Gln Pro Glu Leu Thr Val Gly Thr 
225                 230                 235                 240 


Thr Asn His Ala Asp Ile Gly Phe Ile Thr Ile Leu Leu Gln Asp His 
                245                 250                 255     


Val Gly Gly Leu Gln Val Phe Tyr Gln Asp Gln Trp Ile Asp Val Pro 
            260                 265                 270         


Pro Ile Thr Gly Ala Leu Val Leu Asn Ala Gly Asp Ile Leu Gln Met 
        275                 280                 285             


Ile Thr Asn Asp Lys Phe Val Ser Ala Gln His Lys Val Leu Ala Asn 
    290                 295                 300                 


Lys Ile Gly Pro Arg Val Ser Val Ala Ser Phe Phe Arg Thr Asp Ser 
305                 310                 315                 320 


Val Pro Thr Leu Lys Val Phe Glu Pro Ile Lys Glu Leu Leu Ser Glu 
                325                 330                 335     


His Asn Pro Ser Lys Tyr Arg Gly Thr Thr Met Gln Glu Tyr Ala Asp 
            340                 345                 350         


His Phe Arg Ala Lys Gly Leu Asp Gly Thr Ser Pro Leu Leu His Phe 
        355                 360                 365             


Lys Ile 
    370 


<210>  434
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  434

Met Glu Ser Gly Asp Cys Asp Glu Asn Lys Ala Phe Ser Ile Gly Glu 
1               5                   10                  15      


Pro Pro Gln Glu Asn Gly Leu Ser His Val Pro Arg Ser Tyr Glu Ile 
            20                  25                  30          


Ser Ser Ser Asn Arg Pro Ser Leu Asn Pro Glu Ile Ala Asn Val Ala 
        35                  40                  45              


Val Val Asp Leu Val Gly Leu Asn Asp Pro Asp Gln Arg Pro Met Val 
    50                  55                  60                  


Val Lys Asn Ile Gly Ser Ala Cys Arg Glu Ser Gly Phe Phe Gln Ile 
65                  70                  75                  80  


Ile Asn His Gly Ile Ser Gln Lys Val Leu Asp Glu Ala Leu Gly Thr 
                85                  90                  95      


Ala Phe Ala Phe Phe Asp Leu Pro Thr Thr Glu Lys Glu Lys Tyr Met 
            100                 105                 110         


Ser Asn Asp Val His Lys Pro Val Arg Tyr Gly Thr Ser Ile Lys Asp 
        115                 120                 125             


Glu Val Asp Lys Ile Gln Tyr Arg Arg Gly Phe Leu Lys His Tyr Ala 
    130                 135                 140                 


His Pro Leu Asn Glu Trp Ile Gln Glu Trp Pro Asp Lys Pro His Asp 
145                 150                 155                 160 


Tyr Arg Asp Lys Met Gly Ser Tyr Val Met Lys Ala Arg Arg Leu Ser 
                165                 170                 175     


Ile Glu Ile Met Gly Ala Ile Thr Glu Ser Leu Gly Ile Gly Arg Lys 
            180                 185                 190         


Tyr Leu Glu Asn Lys Met Glu Asp Gly Met Gln Val Met Ala Val Asn 
        195                 200                 205             


Cys Tyr Pro Lys Cys Pro Glu Pro His Leu Ala Leu Gly Val Pro Pro 
    210                 215                 220                 


His Ser Asp His Thr Cys Ile Thr Ile Val Leu Gln Ser Ser Cys Gly 
225                 230                 235                 240 


Leu Glu Ile Ile Asp Ala Ala Asp Gly Thr Trp Arg Leu Val Pro Glu 
                245                 250                 255     


Leu Gln Gly Ala Leu Glu Val His Val Gly Asp His Val Glu Val Leu 
            260                 265                 270         


Ser Asn Gly Leu Tyr Lys Ser Met Val His Arg Val Thr Leu Asn Asn 
        275                 280                 285             


Glu Arg Thr Arg Ile Ser Ile Val Ser Leu His Ser Met Gly Leu Asp 
    290                 295                 300                 


Glu Lys Met Ala Thr Ala Gln Glu Leu Val Ser Asp Glu Asn Pro Lys 
305                 310                 315                 320 


Lys Tyr Lys Glu Ser Ser Phe Arg Asp Phe Leu Asn Phe Leu Thr Arg 
                325                 330                 335     


Asn Glu Gly Lys Ser Tyr Ile Glu Ser Leu Lys Met Asp Lys Met Gly 
            340                 345                 350         


Ser Tyr Val Met Lys Ala Arg Arg Leu Ser Ile Glu Ile Met Gly Ala 
        355                 360                 365             


Ile Thr Glu Ser Leu Gly Ile Gly Arg Lys Tyr Leu Glu Asn Lys Met 
    370                 375                 380                 


Glu Asp Gly Met Gln Val Met Ala Val Asn Cys Tyr Pro Lys Cys Pro 
385                 390                 395                 400 


Glu Pro His Leu Ala Leu Gly Val Pro Pro His Ser Asp His Thr Cys 
                405                 410                 415     


Ile Thr Ile Val Leu Gln Ser Ser Cys Gly Leu Glu Ile Ile Asp Ala 
            420                 425                 430         


Ala Asp Gly Thr Trp Arg Leu Val Pro Glu Leu Gln Gly Ala Leu Glu 
        435                 440                 445             


Val His Val Gly Asp His Val Glu Val Leu Ser Asn Gly Leu Tyr Lys 
    450                 455                 460                 


Ser Met Val His Arg Val Thr Leu Asn Asn Glu Arg Thr Arg Ile Ser 
465                 470                 475                 480 


Ile Val Ser Leu His Ser Met Gly Leu Asp Glu Lys Met Ala Thr Ala 
                485                 490                 495     


Gln Glu Leu Val Ser Asp Glu Asn Pro Lys Lys Tyr Lys Glu Ser Ser 
            500                 505                 510         


Phe Arg Asp Phe Leu Asn Phe Leu Thr Arg Asn Glu Gly Lys Ser Tyr 
        515                 520                 525             


Ile Glu Ser Leu Lys Met 
    530                 


<210>  435
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  435

Met Gly Leu Thr Gln Asp Asp Phe Asp Arg Glu Ser Glu Leu Lys Ala 
1               5                   10                  15      


Phe Asp Glu Thr Lys Gly Gly Val Lys Gly Leu Val Asp Ser Gly Ile 
            20                  25                  30          


Thr Lys Val Pro Gln Ile Phe Ile Gln Pro Pro Asp Asp Phe Pro Gln 
        35                  40                  45              


Ala Asn Asn Lys Phe Asp Leu Pro Asn Ile Asp Leu His Gly Phe Asp 
    50                  55                  60                  


Ser Asn Pro Val Arg Arg Asn Glu Ile Val Lys Glu Ile Lys Glu Ala 
65                  70                  75                  80  


Ser Arg Thr Trp Gly Phe Phe Gln Val Ile Asn His Glu Ile Pro Val 
                85                  90                  95      


Ser Val Leu Arg Glu Met Arg Asp Gly Ala Leu Arg Phe Phe Asn Met 
            100                 105                 110         


Asp His Glu Val Lys Arg Glu Trp Tyr Val Thr Asp Ser Thr Lys Lys 
        115                 120                 125             


Ile Phe Tyr Asn Ser Asn Val Asp Leu Ser Ser Thr Leu Pro Val Arg 
    130                 135                 140                 


Trp Arg Asp Ser Phe His Cys Arg Met Ala Pro Asp Pro Pro Asn Pro 
145                 150                 155                 160 


Gln Glu Leu Pro Pro Leu Cys Arg Asp Ile Leu Ile Glu Tyr Ser Lys 
                165                 170                 175     


Gln Val Thr Lys Leu Gly Ser Ser Leu Phe Glu Leu Ile Ser Glu Ala 
            180                 185                 190         


Leu Gly Leu Arg Ser Ser Tyr Leu Lys Asp Ile Gly Cys Ala Asp Gly 
        195                 200                 205             


Leu Ala Thr Ile Cys His Tyr Tyr Pro Ala Ser Pro Gln Pro Glu Leu 
    210                 215                 220                 


Thr Ile Gly Ala Arg Lys His Ala Asp Asn Asp Phe Leu Thr Val Leu 
225                 230                 235                 240 


Leu Gln Asp His Ile Gly Gly Leu Gln Phe Leu His Lys Asn Gln Trp 
                245                 250                 255     


Val Asn Val Pro Phe Val Pro Gly Ala Leu Val Val Asn Ile Gly Asp 
            260                 265                 270         


Leu Leu Gln Leu Met Ser Asn Asp Lys Val Met Ser Ala Glu His Arg 
        275                 280                 285             


Val Val Ser Ser Cys Ala Gly Pro Arg Val Ser Val Ala Cys Phe Phe 
    290                 295                 300                 


Thr Thr Gly Met Val Glu Thr Gly Lys Val Phe Glu Pro Ile Lys Glu 
305                 310                 315                 320 


Leu Leu Ser Glu Glu Asn Pro Ala Lys Tyr Arg Pro Thr Thr Met Lys 
                325                 330                 335     


Ala Phe Val Gln His Ser His Ser Lys Val Phe Asp Lys Ser Ser Met 
            340                 345                 350         


Ser His Phe Arg Ile 
        355         


<210>  436
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  436

Met Ala Ile Asn His Tyr Pro Pro Cys Pro Asp Pro Ser Leu Ala Met 
1               5                   10                  15      


Gly Ile Gly Gly His Thr Asp Pro Asn Leu Ile Thr Phe Leu Gln Gln 
            20                  25                  30          


Asp His Tyr Gly Leu Gln Ile Leu Lys Asp Gly Gln Trp Met Gly Ile 
        35                  40                  45              


Glu Pro Ile Pro Asn Ala Phe Val Val Asn Leu Gly Cys Gln Leu Gln 
    50                  55                  60                  


Ile Ile Ser Asn Gly Lys Leu Lys Ser Ala Glu His Arg Gly Val Leu 
65                  70                  75                  80  


Asn Ser Thr Ala Ser Arg Thr Ser Ile Val Thr Phe Leu Gly Pro Asp 
                85                  90                  95      


Ser Thr Leu Pro Leu Val Val Gly Pro Ala Lys Glu Leu Val Thr Ser 
            100                 105                 110         


Thr Thr Pro Gln Val Phe Lys Ser Tyr Leu Tyr Asn Glu Phe Leu Ala 
        115                 120                 125             


Glu Tyr Leu Ala Phe Ile Arg Lys Pro Asp Pro Arg Asn Gly Thr Pro 
    130                 135                 140                 


Leu Asp Pro Tyr Arg Ile 
145                 150 


<210>  437
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  437

Met Gly Leu Thr Gln Asp Asp Phe Asp Arg Glu Ser Glu Leu Lys Ala 
1               5                   10                  15      


Phe Asp Glu Thr Lys Gly Gly Val Lys Gly Leu Val Asp Ser Gly Ile 
            20                  25                  30          


Thr Lys Val Pro Gln Ile Phe Ile Gln Pro Pro Asp Asp Phe Pro Gln 
        35                  40                  45              


Ala Asn Asn Lys Phe Asp Leu Pro Asn Ile Asp Leu His Gly Phe Asp 
    50                  55                  60                  


Ser Asn Pro Val Arg Arg Asn Glu Ile Val Lys Glu Ile Lys Glu Ala 
65                  70                  75                  80  


Ser Arg Thr Trp Gly Phe Phe Gln Val Ile Asn His Glu Ile Pro Val 
                85                  90                  95      


Ser Val Leu Arg Glu Met Arg Asp Gly Ala Leu Arg Phe Phe Asn Met 
            100                 105                 110         


Asp His Glu Val Lys Lys Glu Trp Tyr Val Thr Asp Ser Thr Lys Lys 
        115                 120                 125             


Ile Phe Tyr Asn Ser Asn Val Asp Leu Ser Ser Thr Leu Pro Val Arg 
    130                 135                 140                 


Trp Arg Asp Ser Phe His Cys Arg Met Ala Pro Asp Pro Pro Asn Pro 
145                 150                 155                 160 


Gln Glu Leu Pro Pro Leu Cys Arg Asp Ile Leu Ile Glu Tyr Ser Lys 
                165                 170                 175     


Gln Val Thr Lys Leu Gly Ser Ser Leu Phe Glu Leu Ile Ser Glu Ala 
            180                 185                 190         


Leu Gly Leu Arg Ser Ser Tyr Leu Lys Asp Ile Gly Cys Ala Asp Gly 
        195                 200                 205             


Leu Ala Ala Ile Cys His Tyr Tyr Pro Ala Ser Pro Gln Pro Glu Leu 
    210                 215                 220                 


Thr Ile Gly Ala Arg Lys His Ala Asp Asn Asp Phe Leu Thr Val Leu 
225                 230                 235                 240 


Leu Gln Asp His Ile Gly Gly Leu Gln Phe Leu His Lys Asn Gln Trp 
                245                 250                 255     


Val Asn Val Pro Phe Val Pro Gly Ala Leu Val Val Asn Ile Gly Asp 
            260                 265                 270         


Leu Leu Gln Leu Met Ser Asn Asp Lys Val Met Ser Ala Glu His Arg 
        275                 280                 285             


Val Val Ser Ser Cys Ala Gly Pro Arg Val Ser Val Ala Cys Phe Phe 
    290                 295                 300                 


Thr Thr Gly Met Val Glu Thr Gly Lys Val Phe Glu Pro Ile Lys Glu 
305                 310                 315                 320 


Leu Leu Ser Glu Glu Asn Pro Ala Lys Tyr Arg Pro Thr Thr Met Lys 
                325                 330                 335     


Ala Phe Val Gln His Ser His Ser Lys Val Phe Asp Lys Ser Ser Met 
            340                 345                 350         


Ser His Phe Arg Ile 
        355         


<210>  438
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  438

Met Thr Ser Ala Val Gly Ser Asn Tyr Asp Arg Gly Ser Glu Leu Lys 
1               5                   10                  15      


Ala Phe Asp Asp Thr Lys Thr Gly Val Lys Gly Leu Val Asp Ala Gly 
            20                  25                  30          


Leu Ser Lys Val Pro Ser Ile Phe Ile His Asp Gln Pro Ile Thr Asn 
        35                  40                  45              


Lys Ala His Ser Ser Thr Thr Gln Thr Arg Val Asn Ile Pro Val Ile 
    50                  55                  60                  


Asp Leu Asn Gly Thr Asn Val Arg Asn Glu Ile Ile Glu Asn Val Arg 
65                  70                  75                  80  


Asp Ala Cys Glu Asn Trp Gly Phe Phe Gln Ile Ile Asn His Gly Ile 
                85                  90                  95      


Pro Lys Arg Val Leu Asp Glu Met Ile Asp Gly Val Leu Lys Phe His 
            100                 105                 110         


Glu Met Glu Thr Glu Glu Lys Ile Gln Tyr Tyr Ser Arg Asp Phe Arg 
        115                 120                 125             


Lys Arg Phe Phe Cys Val Ser Asn Phe His Leu Phe Thr Asp Asp Ala 
    130                 135                 140                 


Ala Thr Trp Ser Asp Ser Phe Leu Ser Val Met Ala Pro Asp Cys Pro 
145                 150                 155                 160 


Gln Phe Glu Glu Met Pro Ser Val Cys Arg Asp Ile Leu Ile Glu Tyr 
                165                 170                 175     


Ser Asn His Val Met Arg Val Gly Leu Thr Leu Leu Glu Leu Phe Ser 
            180                 185                 190         


Lys Ser Leu Gly Leu Glu Pro Asn His Leu Lys Asn Leu Gly Cys Ala 
        195                 200                 205             


Glu Gly Leu Phe Leu Leu Gly His Tyr Tyr Pro Ala Cys Pro Glu Pro 
    210                 215                 220                 


Glu Leu Thr Leu Gly Ala Asn Cys His Thr Asp Ala Gly Phe Phe Thr 
225                 230                 235                 240 


Ile Ile Leu Gln Asp Leu Leu Gly Gly Leu Gln Val Leu His Gln Asn 
                245                 250                 255     


Asp Trp Val Asp Val Lys Pro Leu Ser Gly Ala Leu Val Val Asn Val 
            260                 265                 270         


Ala Asp Leu Leu Gln Ala Ser Leu Arg Tyr Tyr Glu Lys Phe Met Ser 
        275                 280                 285             


Thr Ile Val 
    290     


<210>  439
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  439

Met Glu Arg Gly Asp Cys Asp Glu Lys Lys Ala Phe Ser Ile Gly Glu 
1               5                   10                  15      


Thr Pro Gln Glu Lys Gly Leu Ser His Val Pro Arg Ser Tyr Glu Ile 
            20                  25                  30          


Ser Leu Ser His Arg Pro Ser Leu Asn Pro Glu Ile Ala Asn Val Ala 
        35                  40                  45              


Val Val Asp Leu Val Gly Leu Asn Asp Pro Asn Gln Arg Ser Met Val 
    50                  55                  60                  


Val Lys Asn Ile Gly Tyr Ala Cys Arg Glu Ser Gly Val Phe Gln Ile 
65                  70                  75                  80  


Ile Asn His Gly Ile Ser Gln Lys Val Leu Asp Glu Ala Leu Gly Thr 
                85                  90                  95      


Ala Phe Gly Phe Phe Asp Leu Pro Thr Thr Glu Lys Ala Lys Tyr Met 
            100                 105                 110         


Ser Asn Asp Val His Lys Pro Val Arg Tyr Gly Thr Ser Ile Lys Asp 
        115                 120                 125             


Gly Asp Asp Lys Ile Gln Tyr Trp Arg Met Phe Leu Lys His Tyr Ala 
    130                 135                 140                 


His Pro Leu Asn Glu Trp Ile Gln Gln Trp Pro Asp Lys Pro His Asp 
145                 150                 155                 160 


Tyr Arg Asp Lys Met Gly Ser Tyr Val Met Lys Ala Arg Arg Leu Ala 
                165                 170                 175     


Ile Glu Ile Met Gly Ala Ile Thr Glu Ser Leu Gly Ile Gly Pro Lys 
            180                 185                 190         


Tyr Leu Glu Asn Lys Met Glu Asp Gly Met Gln Val Ile Ala Val Asn 
        195                 200                 205             


Cys Tyr Pro Lys Cys Pro Glu Pro His Leu Ala Leu Gly Leu Pro Pro 
    210                 215                 220                 


His Ser Asp Tyr Ser Cys Ile Thr Ile Val Leu His Ser Ser Val Gly 
225                 230                 235                 240 


Leu Glu Ile Met Asp Ala Ala Asp Gly Thr Trp His Leu Val Pro Glu 
                245                 250                 255     


Leu His Gly Ala Leu Leu Val His Val Gly Asp His Val Glu Val Leu 
            260                 265                 270         


Ser Asn Gly Gln Tyr Lys Ser Met Val His Arg Val Thr Leu Asn Asn 
        275                 280                 285             


Glu Arg Thr Arg Ile Ser Ile Ala Ser Leu His Ser Met Gly Ile Asp 
    290                 295                 300                 


Glu Lys Met Glu Thr Ala Gln Glu Leu Val Ser Asp Glu Asn Pro Lys 
305                 310                 315                 320 


Lys Tyr Lys Glu Ser Ser Phe Arg Asp Phe Leu Asp Phe Leu Thr Gln 
                325                 330                 335     


Asn Asp Ile Ser Glu Gly Lys Ser Phe Ile Glu Ser Leu Lys Met Lys 
            340                 345                 350         


<210>  440
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  440

Met Ser Phe Val Pro Ile Ile Asp Tyr Ser Leu Leu Thr Ser Gly Thr 
1               5                   10                  15      


Pro Asn Glu Arg Ser Lys Val Ile Gln Gln Leu Gly Asn Ala Cys Lys 
            20                  25                  30          


Asp Trp Gly Cys Tyr Met Leu Val Asn His Gly Ile Pro Glu Thr Leu 
        35                  40                  45              


Ile Lys Glu Ile Met Asp Val Ser Asp Glu Phe Phe Asn Leu Pro Lys 
    50                  55                  60                  


Glu Glu Lys Leu Glu Phe Glu Ala Phe Gly Val Phe Asp Pro Ile Arg 
65                  70                  75                  80  


Phe Ser Ser Gly Phe Asn Ala Val Glu Gln Asn Lys Asp Thr Leu Trp 
                85                  90                  95      


Arg Glu Val Leu Arg Leu Ile Ala His Pro Asp Phe His Cys Pro His 
            100                 105                 110         


Lys Pro Ser Gly Phe Ser Glu Ile Ala Ser Asp Tyr Val Lys Arg Thr 
        115                 120                 125             


Gln Val Ile Val Asn Glu Leu Leu Lys Gly Val Ser Glu Ser Leu Gly 
    130                 135                 140                 


Phe Glu Ala Ser Tyr Met Asn Lys Glu Leu Asn Leu Asp Ser Ser Phe 
145                 150                 155                 160 


Arg Leu Leu Ala Val Asn Cys Tyr Pro Phe Leu Pro Asp Phe Asp Leu 
                165                 170                 175     


Ala Arg Gly Leu Met Pro His Thr Asp His Gly Val Phe Thr Leu Leu 
            180                 185                 190         


Tyr Glu Asn Asp Val Pro Gly Leu Glu Val Phe His Asn Gly Lys Trp 
        195                 200                 205             


Val Val Met Ser Gly Val Pro Asn Ala Phe Leu Val Leu Ser Ala Asp 
    210                 215                 220                 


His Leu Glu Ile Phe Ser Asn Gly Val Tyr Lys Ser Lys Leu His Arg 
225                 230                 235                 240 


Ala Val Val Lys Asp Glu Cys Lys Arg Ile Thr Leu Val Asn Thr Asn 
                245                 250                 255     


Gly Pro Ser Leu Asp Thr Val Val Gly Pro Ser Pro Arg Leu Val Asp 
            260                 265                 270         


Glu Gln Asp Arg Pro Ala Gly Tyr Leu Pro Met Lys Tyr Gly Glu Tyr 
        275                 280                 285             


Leu Glu Leu Gln Thr Lys Leu Thr Thr Ala Gly Lys His Ala Phe Asp 
    290                 295                 300                 


Ile Val Arg Ile Gln Asn 
305                 310 


<210>  441
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  441

Met Glu His Gly Glu Ile Ser Val Gly Asp Phe Thr Ser Ala Met Thr 
1               5                   10                  15      


Leu Thr His Asp His Glu Arg Gly Glu Asn Ile Pro Glu Arg Tyr Ile 
            20                  25                  30          


Leu Pro Pro Leu Gln Arg Pro Asn Pro Asn Leu Ile Asp His Pro Leu 
        35                  40                  45              


Thr Ser Leu Pro Val Ile Asp Leu Ser Leu Leu Asn Asp Pro Leu Leu 
    50                  55                  60                  


Arg Ser Arg Ala Thr Asn Glu Ile His Ala Ala Cys Asn Asn Leu Gly 
65                  70                  75                  80  


Phe Phe Gln Val Val Asn His Gly Ile Pro Ile Ser Val Met Gln Asp 
                85                  90                  95      


Ala Leu Asp Val Ala Thr Glu Phe Phe His Leu Pro Ser Glu Glu Lys 
            100                 105                 110         


Met Gln Phe Ala Ser Ala Asn Val Arg Glu Pro Val Arg Tyr Gly Thr 
        115                 120                 125             


Ser Met Asn His Met Val Asp Lys Val Leu Cys Trp Arg Asp Phe Ile 
    130                 135                 140                 


Lys His Tyr Ala Asn Pro Ile Gln Glu Trp Ile His Leu Trp Pro Ser 
145                 150                 155                 160 


Thr Pro Ser Ser Tyr Arg Glu Lys Met Gly Thr Tyr Ala Lys Ala Val 
                165                 170                 175     


His Thr Leu Gln Lys Gln Leu Met Ala Ile Val Leu Glu Asn Leu Gly 
            180                 185                 190         


Leu Asn Ala Asn Tyr Leu His Glu Asp Ile Glu Ala Gly Cys Gln Val 
        195                 200                 205             


Met Ala Val Asn Cys Tyr Pro Pro Cys Pro Lys Pro Asp Leu Ala Leu 
    210                 215                 220                 


Gly Met Leu Pro His Ser Asp Tyr Gly Thr Ile Thr Ile Leu Asn Gln 
225                 230                 235                 240 


Asn Gln Gln Gly Leu Glu Ile Met Asp Asn Asp Asn Thr Trp His Ser 
                245                 250                 255     


Val Pro Phe Ile Gln Gly Ala Leu Ile Val Gln Leu Gly Asp Gln Val 
            260                 265                 270         


Glu Leu Ile Ser Asn Gly Arg His Lys Ser Thr Ile His Arg Ala Thr 
        275                 280                 285             


Val Asn Thr Glu Arg Lys Arg Leu Ser Ile Ala Ser Val His Ser Leu 
    290                 295                 300                 


Pro Ile Val Lys Lys Val Gly Pro Ala Pro Gln Leu Val Asp Glu Gln 
305                 310                 315                 320 


His Pro Ile Ala Tyr Lys Glu Gly Ser Phe Ser Glu Phe Leu Asp Tyr 
                325                 330                 335     


Ile Ser Val Asn Cys Leu Leu Glu Ala Arg Tyr Ile Asp Thr Leu Lys 
            340                 345                 350         


Ile Gln 
        


<210>  442
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  442

Met Asp Ser Gly Asp Ser Asn Glu Asn Lys Ala Phe Pro Ile Gly Glu 
1               5                   10                  15      


Thr Pro Gln Glu Arg Gly Phe Ser Asn Val Pro Arg Cys Tyr Glu Ile 
            20                  25                  30          


Ser Ser Ser Asp Arg Pro Ser Leu Asn Pro Lys Ile Ala Asp Val Val 
        35                  40                  45              


Val Val Asp Leu Ser Gly Leu Asn Asp Pro Asn Gln Arg Pro Met Ile 
    50                  55                  60                  


Val Lys Asn Ile Gly Asn Val Cys Arg Glu Ser Gly Phe Phe Gln Ile 
65                  70                  75                  80  


Ile Asn His Gly Ile Pro Gln Lys Val Leu Asp Glu Ala Leu Gly Thr 
                85                  90                  95      


Ala Phe Glu Phe Phe Asp Leu Pro Thr Ser Glu Lys Ala Lys Tyr Met 
            100                 105                 110         


Ser Asn Asp Val His Lys Pro Val Arg Tyr Gly Thr Ser Ile Lys Asp 
        115                 120                 125             


Gly Val Asp Lys Ile Gln Phe Trp Arg Val Phe Leu Lys His Tyr Ala 
    130                 135                 140                 


His Pro Leu Asn Glu Trp Ile Gln Gln Trp Pro Asp Lys Pro Gln Asp 
145                 150                 155                 160 


Tyr Arg Gln Tyr Leu Phe His Gln Lys Ile Phe Leu Tyr Leu Ser Tyr 
                165                 170                 175     


Val His Cys Arg Asp Lys Met Gly Asp Tyr Val Met Lys Ala Arg His 
            180                 185                 190         


Leu Ala Ile Glu Ile Ile Gly Ala Ile Thr Glu Ser Leu Gly Ile Gly 
        195                 200                 205             


Pro Lys Tyr Leu Glu Asn Lys Met Glu Asp Gly Met Gln Val Met Ala 
    210                 215                 220                 


Val Asn Cys Tyr Pro Lys Cys Pro Glu Pro Gln Leu Ala Leu Gly Leu 
225                 230                 235                 240 


Pro Pro His Ser Asp Tyr Ser Cys Ile Thr Ile Val Leu His Ser Ser 
                245                 250                 255     


Cys Gly Leu Glu Ile Met Asp Ala Ser Asp Gly Thr Trp His Leu Val 
            260                 265                 270         


Pro Glu Leu His Gly Ala Leu Gln Val His Val Gly Asp His Val Glu 
        275                 280                 285             


Val Leu Ser Asn Gly Leu Tyr Lys Ser Met Val His Arg Val Thr Leu 
    290                 295                 300                 


Asn Asn Glu Arg Thr Arg Ile Ser Ile Ala Ser Leu His Ser Met Gly 
305                 310                 315                 320 


Met Asp Glu Lys Met Ala Thr Ala Ala 
                325                 


<210>  443
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  443

Met Asp Ile Ser Asn Ser Asn Asp Asp Arg Thr Lys Gln Leu Lys Ala 
1               5                   10                  15      


Phe Asp Asp Thr Lys Cys Gly Val Lys Gly Phe Leu Asp Thr Ser Ala 
            20                  25                  30          


Gly Gly Val Val Asp Val Pro Gln Ile Phe Ile Arg Pro Pro Glu Glu 
        35                  40                  45              


Val Ala Glu Asp Leu Glu Leu Gly Arg Thr Ser Leu Arg Val Pro Ala 
    50                  55                  60                  


Ile Asp Leu Ser Gly Val Gly Asp Lys Gly Ser Cys Thr Arg Glu Lys 
65                  70                  75                  80  


Ile Val Glu Gln Val Lys Leu Ala Ser Glu Gln Trp Gly Phe Phe Gln 
                85                  90                  95      


Val Val Asn His Gly Ile Pro Val Lys Val Leu Glu Ala Met Leu Asn 
            100                 105                 110         


Gly Val Arg Glu Phe Asn Glu Gln Asp Val Glu Leu Lys Lys Glu Tyr 
        115                 120                 125             


Tyr Ser Arg Asp Pro Glu Arg Met Val Lys Leu Asn Thr Ser Phe Asp 
    130                 135                 140                 


Phe Tyr Met Ala Lys Ser Ala Ser Trp Arg Asp Thr Leu Ser Val Asp 
145                 150                 155                 160 


Met Leu Tyr Ser Asp His Leu Asp Pro Gln Asp Leu Pro Ser Pro Cys 
                165                 170                 175     


Arg Asn Ala Thr Val Asp Tyr Leu Asn Gln Val Met Glu Leu Ala Asp 
            180                 185                 190         


Val Leu Tyr Glu Leu Leu Ser Glu Ala Leu Gly Leu Glu Pro Asn Tyr 
        195                 200                 205             


Leu Lys Gln Leu Glu Cys Glu Lys Gly Arg Thr Leu Ala Cys Asn Tyr 
    210                 215                 220                 


Phe Pro Pro Cys Pro Lys Pro Asp Leu Thr Leu Gly Val Asn Lys His 
225                 230                 235                 240 


Thr Asp Ala Ser Phe Ile Thr Ile Leu Leu Gln Asp Glu Val Gly Gly 
                245                 250                 255     


Leu Gln Val Leu His Gln Asn Lys Trp Ala Asp Val Gly Pro Ile Pro 
            260                 265                 270         


Gly Ala Leu Val Val Asn Thr Gly Asp Leu Leu Gln Ser Met Lys Ser 
        275                 280                 285             


Gly Phe Leu Asp Ser Gly Gly Gly Gly Glu Lys Lys Lys Lys Lys Lys 
    290                 295                 300                 


Asp Asp Ser Leu Ala Gly Arg Pro Ile Leu Asp Thr Arg Thr Ser Arg 
305                 310                 315                 320 


Thr Gly Asn Leu Asp Leu His Ser Asn Leu Pro Lys Leu Ser Glu Cys 
                325                 330                 335     


Trp His Arg Lys Phe Ala Ile Arg Lys Leu Gly Arg Trp Asn Arg Arg 
            340                 345                 350         


Gln Ala Ala 
        355 


<210>  444
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  444

Met Ser Glu Met Lys Met Pro Arg Glu Gly Val Pro Val Ile Asp Met 
1               5                   10                  15      


Gln Lys Phe Asp Thr Leu Ser Met Glu Ile Val Lys Ala Ser Glu Glu 
            20                  25                  30          


Trp Gly Cys Phe Arg Ile Val Asn His Gly Ile Ser Met Asp Leu Met 
        35                  40                  45              


Ala Glu Met Lys Thr Val Val Ala Ser Leu Phe Asp Gln Pro Glu Glu 
    50                  55                  60                  


Ile Lys Met Arg Thr Val His Thr Glu Val Gly Lys Gly Tyr Val Lys 
65                  70                  75                  80  


Arg Asn Leu Ala Gly Pro Cys Phe Glu Gly Phe Ser Ile Asp Asp Ile 
                85                  90                  95      


Ser Leu Pro Gly Glu Phe Cys Asp Arg Ile Asn Ala Ser Val His Gln 
            100                 105                 110         


Arg Lys Ile Ile Asn Lys Tyr Ile Lys Ala Ile Arg Asp Leu Ala Arg 
        115                 120                 125             


Leu Leu Gly Leu Lys Leu Met Glu Gly Ser Gly Leu Asn Gly Asp Leu 
    130                 135                 140                 


Phe Asp Gly Trp Cys Cys Gln Leu Arg Met Asn Lys Tyr His Phe Cys 
145                 150                 155                 160 


Pro Lys Ser Ile Gly Ser Thr Gly Val Pro Ile His Thr Asp Pro Thr 
                165                 170                 175     


Phe Leu Thr Ile Leu Gln Asp Asp Glu Asn Val Asn Gly Leu Gln Leu 
            180                 185                 190         


Ile Asp Lys Asn Ser Gly Gln Phe Ile Pro Val Asp Pro Val Pro Gly 
        195                 200                 205             


Thr Leu Ala Val Asn Ile Gly Asp Ile Gly Lys Leu Phe Ser Gln Ile 
    210                 215                 220                 


Phe Lys Glu Ile Met Cys Ile 
225                 230     


<210>  445
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  445

Met Ile Lys Ile Leu Leu Lys Ile Thr Leu Phe Pro Pro Met Asp Ala 
1               5                   10                  15      


Tyr Ile Tyr Leu Thr Lys Leu Ser Ile Cys Ser Ser Ser Asn Asn Asn 
            20                  25                  30          


Lys Leu Ala Lys Ile Thr Lys Lys Met Glu Ile Pro Met Ile Asp Phe 
        35                  40                  45              


Ser Lys Leu Asp Gly Glu Asp Arg Ser Lys Thr Met Ala Leu Leu His 
    50                  55                  60                  


His Ala Cys Glu Lys Trp Gly Phe Phe Gln Ile Glu Asn His Gly Val 
65                  70                  75                  80  


Asp Lys Lys Leu Met Asp Lys Val Lys Lys Leu Val Asn Gln His Tyr 
                85                  90                  95      


Glu Glu Asn Met Lys Lys Ser Phe Tyr Ser Ser Glu Ile Val Lys Lys 
            100                 105                 110         


Val Glu Asp His Asn Lys Thr Thr Asp Ile Asp Trp Glu Ser Thr Phe 
        115                 120                 125             


Phe Leu Trp His Arg Pro Asp Asn Lys Ile Asn Glu Tyr Thr Asn Leu 
    130                 135                 140                 


Thr Glu Glu Leu Arg Glu Thr Val Asp Glu Tyr Ile Asn Gln Leu Ile 
145                 150                 155                 160 


Lys Val Ala Glu Thr Leu Ser Glu Leu Met Cys Glu Asn Leu Gly Leu 
                165                 170                 175     


Asp Lys Asp Tyr Ile Lys Glu Ala Phe Thr Gly Thr Lys Gly Pro Ser 
            180                 185                 190         


Val Gly Thr Lys Val Ala Lys Tyr Pro Lys Cys Pro His Pro Glu Leu 
        195                 200                 205             


Val Arg Gly Leu Arg Glu His Thr Asp Ala Gly Gly Ile Ile Leu Leu 
    210                 215                 220                 


Leu Gln Asp Asp Gln Val Pro Gly Leu Glu Phe Phe Lys Asp Asp Gln 
225                 230                 235                 240 


Trp Val Asn Ile Pro Pro Ser Lys Asn Asn Thr Ile Phe Val Asn Thr 
                245                 250                 255     


Gly Asp Gln Val Glu Val Leu Ser Asn Gly Leu Tyr Lys Ser Thr Val 
            260                 265                 270         


His Arg Val Met Thr Asp Lys Asp Gly Ser Arg Leu Ser Ile Ala Thr 
        275                 280                 285             


Phe Tyr Asn Pro Ala Gly Asp Ala Val Ile Ser Pro Ala Gln Lys Leu 
    290                 295                 300                 


Leu Tyr Pro Asn Arg Tyr Thr Phe Gln Asp Tyr Leu Lys Leu Tyr Ser 
305                 310                 315                 320 


Ser Thr Lys Phe Glu Asp Lys Gly Pro Arg Phe Glu Ser Met Lys Lys 
                325                 330                 335     


Thr Val Asn Gly Tyr 
            340     


<210>  446
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (319)..(319)
<223>  Xaa can be any naturally occurring amino acid

<400>  446

Met Glu Ile Pro Met Ile Asp Phe Ser Lys Leu Asp Gly Ala Asp Arg 
1               5                   10                  15      


Ser Lys Thr Met Ala Leu Leu His His Ala Cys Glu Lys Trp Gly Phe 
            20                  25                  30          


Phe Gln Ile Glu Asn His Gly Val Asp Lys Lys Leu Met Asp Lys Val 
        35                  40                  45              


Lys Lys Leu Val Asn Gln His Tyr Glu Glu Asn Met Lys Lys Ser Phe 
    50                  55                  60                  


Tyr Ser Ser Glu Ile Val Lys Lys Val Glu Asp His Asn Lys Thr Thr 
65                  70                  75                  80  


Asp Ile Asp Trp Glu Ser Thr Phe Phe Leu Trp His Arg Pro Asp Asn 
                85                  90                  95      


Lys Ile Asn Glu Tyr Thr Asn Leu Ser Glu Glu Leu Arg Glu Thr Val 
            100                 105                 110         


Asp Glu Tyr Ile Asn Gln Leu Ile Lys Val Ala Glu Thr Leu Ser Glu 
        115                 120                 125             


Leu Met Cys Glu Asn Leu Gly Leu Asp Lys Asp Tyr Ile Lys Glu Ala 
    130                 135                 140                 


Phe Thr Gly Thr Lys Gly Pro Ser Ile Gly Thr Lys Val Ala Lys Tyr 
145                 150                 155                 160 


Pro Lys Cys Pro His Pro Glu Leu Val Arg Gly Leu Arg Glu His Thr 
                165                 170                 175     


Asp Ala Gly Gly Ile Ile Leu Leu Leu Gln Asp Asp Gln Val Pro Gly 
            180                 185                 190         


Leu Glu Phe Phe Lys Asp Asp Gln Trp Val Asn Ile Pro Pro Ser Lys 
        195                 200                 205             


Asn Asn Thr Ile Phe Val Asn Thr Gly Asp Gln Val Glu Val Leu Ser 
    210                 215                 220                 


Asn Gly Leu Tyr Lys Ser Thr Val His Arg Val Met Thr Asp Lys Asp 
225                 230                 235                 240 


Gly Ser Arg Leu Ser Ile Ala Thr Phe Tyr Asn Pro Ala Gly Asp Ala 
                245                 250                 255     


Val Ile Ser Pro Ala Gln Lys Leu Leu Tyr Pro Asn Arg Tyr Thr Phe 
            260                 265                 270         


Gln Asp Tyr Leu Lys Leu Tyr Ser Ser Thr Lys Phe Glu Asp Lys Gly 
        275                 280                 285             


Pro Arg Phe Glu Ser Met Lys Lys Thr Met Cys Ser Gln Gln Leu Gln 
    290                 295                 300                 


Ile Thr Leu Pro Tyr Glu Pro Ser Thr Lys Glu His Thr Tyr Xaa Leu 
305                 310                 315                 320 


Val Asn Arg Arg Pro Asp Gln Glu Thr Val Asp Glu Tyr Ile Asn Gln 
                325                 330                 335     


Leu Ile Lys Val Ala Glu Thr Leu Ser Glu Leu Met Cys Glu Asn Leu 
            340                 345                 350         


Gly Leu Asp Lys Asp Tyr Ile Lys Glu Ala Phe Thr Gly Thr Lys Gly 
        355                 360                 365             


Pro Ser Ile Gly Thr Lys Val Ala Lys Tyr Pro Lys Cys Pro His Pro 
    370                 375                 380                 


Glu Leu Val Arg Gly Leu Arg Glu His Thr Asp Ala Gly Gly Ile Ile 
385                 390                 395                 400 


Leu Leu Leu Gln Asp Asp Gln Val Pro Gly Leu Glu Phe Phe Lys Asp 
                405                 410                 415     


Asp Gln Trp Val Asn Ile Pro Pro Ser Lys Asn Asn Thr Ile Phe Val 
            420                 425                 430         


Asn Thr Gly Asp Gln Val Glu Val Leu Ser Asn Gly Leu Tyr Lys Ser 
        435                 440                 445             


Thr Val His Arg Val Met Thr Asp Lys Asp Gly Ser Arg Leu Ser Ile 
    450                 455                 460                 


Ala Thr Phe Tyr Asn Pro Ala Gly Asp Ala Val Ile Ser Pro Ala Gln 
465                 470                 475                 480 


Lys Leu Leu Tyr Pro Asn Arg Tyr Thr Phe Gln Asp Tyr Leu Lys Leu 
                485                 490                 495     


Tyr Ser Ser Thr Lys Phe Glu Asp Lys Gly Pro Arg Phe Glu Ser Met 
            500                 505                 510         


Lys Lys Thr Val Asn Gly Tyr 
        515                 


<210>  447
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  447

Met Gly Ser Leu Asp Glu Gly Trp Pro Glu Pro Val Val Cys Val Gln 
1               5                   10                  15      


Ser Leu Ser Asp Ser Gly Glu Leu Ser Ile Pro Asp Arg Tyr Ile Lys 
            20                  25                  30          


Pro Gln Pro Glu Arg Pro Ser Leu Ser Val Asn Asp Met Asn Ile Pro 
        35                  40                  45              


Ile Ile Asp Phe Asn Gly Leu Val Thr Ser Pro Glu Ala Thr Met Lys 
    50                  55                  60                  


Gln Ile Ser Lys Ala Cys Arg Glu Trp Gly Phe Phe Gln Leu Val Asn 
65                  70                  75                  80  


His Gly Val Arg Thr Asp Leu Val Asp Gly Val Arg Glu Thr Trp Arg 
                85                  90                  95      


Glu Phe Phe His Glu Pro Met Glu Val Lys Gln Lys Tyr Ala Asn Ser 
            100                 105                 110         


Pro Lys Thr Tyr Glu Gly Phe Gly Ser Arg Leu Gly Thr Glu Lys Gly 
        115                 120                 125             


Ala Ile Leu Asp Trp Ser Asp Tyr Tyr Tyr Leu His Tyr Arg Pro Pro 
    130                 135                 140                 


Cys Asn Thr Lys Trp Pro Asp Gln Gln Pro Ser Leu Arg Glu Met Met 
145                 150                 155                 160 


Glu Glu Tyr Thr Ser Glu Ile Leu Arg Leu Gly Ala Ala Leu Leu Lys 
                165                 170                 175     


Val Phe Ser Val Thr Leu Gly Leu Lys Glu Asp Ser Phe Gln Ser Ala 
            180                 185                 190         


Phe Gly Gly Asn Asp Phe Gly Ala Cys Leu Arg Ala Asn Phe Tyr Pro 
        195                 200                 205             


Lys Cys Pro Gln Pro Asp Leu Thr Leu Gly Leu Ser Ser His Ser Asp 
    210                 215                 220                 


Pro Gly Gly Met Ala Ile Leu Leu Pro Asp Glu Gln Val Cys Gly Leu 
225                 230                 235                 240 


Gln Val Arg Lys Asp Asp Gln Trp Val Thr Val Lys Pro Glu Pro His 
                245                 250                 255     


Ala Ile Ile Val Asn Ile Gly Asp Gln Ile Gln Val Ser Leu Phe Leu 
            260                 265                 270         


Ser Arg Val Phe 
        275     


<210>  448
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  448

Met Asn Ser Ile Ile Ser Ser Arg Asp Thr Leu Glu Ala Tyr Ser Arg 
1               5                   10                  15      


Glu Leu Lys Asn Ile Ala Ile Lys Thr Leu Leu Tyr Ile Ala Lys Ala 
            20                  25                  30          


Leu Arg Met Glu Ser Lys Asp Met Ile Val Leu Phe Glu Glu Gly Met 
        35                  40                  45              


Gln Ala Met Arg Met Asn Tyr Tyr Pro Pro Cys Pro Gln Pro Glu Gln 
    50                  55                  60                  


Val Ile Gly Leu Thr Pro His Ser Asp Ala Gly Gly Ile Thr Phe Leu 
65                  70                  75                  80  


Leu Glu Leu Asn Glu Val Pro Gly Leu Gln Ile Arg Lys Asp Gly Ile 
                85                  90                  95      


Trp Ile Pro Val Lys Pro Leu Pro Asn Ala Phe Ile Val Asn Ile Gly 
            100                 105                 110         


Asp Thr Leu Glu Ile Val Thr Asn Gly Gln Tyr Lys Ser Val Glu His 
        115                 120                 125             


Arg Ala Ile Val Asn Ser Lys Lys Glu Arg Leu Ser Ile Ala Thr Phe 
    130                 135                 140                 


Leu Ser Pro Lys Leu Asp Gly Asp Leu Gly Pro Ala Pro Ser Leu Ile 
145                 150                 155                 160 


Thr Pro Lys Thr Pro Pro Lys Phe Thr Arg Val Thr Val Val Asp Phe 
                165                 170                 175     


Phe Lys Asn Leu Phe Ser Arg Glu Leu Ile Lys Lys Thr Asn Leu Glu 
            180                 185                 190         


Gln Tyr Tyr Val 
        195     


<210>  449
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  449

Met Asp Ala Tyr Gln Asn Glu Met Lys Leu Leu Thr Gln Lys Leu Leu 
1               5                   10                  15      


His Leu Met Leu Gln Thr Leu Asn Val Thr Gln Glu Glu Met Asn Trp 
            20                  25                  30          


Ala Ile Ser Ala Gln Asp Ser Gln Thr Ala Leu Gln Leu Asn Ser Tyr 
        35                  40                  45              


Pro Ser Cys Pro Asn Pro Ser Asn Ala Ile Gly Leu Ala Pro His Thr 
    50                  55                  60                  


Asp Ser Leu Leu Leu Thr Leu Leu His Gln Gly Gly Ala Asn Gly Leu 
65                  70                  75                  80  


Glu Ile Phe Val Glu Gly Leu Gly Trp Ser Pro Val Asn Pro Val Asp 
                85                  90                  95      


Gly Ala Phe Val Val Asn Ile Gly Asp Leu Leu His Ile Leu Ser Asn 
            100                 105                 110         


Ala Thr Phe Gln Ala Val Asn His Arg Ala Arg Val Asn Gln Ala Lys 
        115                 120                 125             


Gln Arg Ile Ser Val Ala Tyr Phe His Gly Pro Pro Val Glu Ser Val 
    130                 135                 140                 


Val Ala Pro Ser Ser Ser Phe Glu Asn Pro Cys Phe Arg Ser Met Leu 
145                 150                 155                 160 


Val Lys Glu Phe Leu Ser Leu Lys Ala Lys Asn Phe His Lys Ala Leu 
                165                 170                 175     


Ser Met Ile Arg Lys 
            180     


<210>  450
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  450

Met Glu Val Leu Thr Ser Asn Trp Ser Asn Val Gln Thr Leu Pro Asp 
1               5                   10                  15      


Asn Tyr Ile Phe Pro Pro Asp Arg Arg Pro Gly Thr Lys Lys Ile Leu 
            20                  25                  30          


Ser Ser Lys Asp Ile Pro Ile Ile Asn Leu Glu Arg Ile Asn Gly Pro 
        35                  40                  45              


Glu Arg Asp Gln Ile Ile Gln Gln Ile Ile Lys Ser Ser Glu Asp Phe 
    50                  55                  60                  


Gly Leu Phe Gln Val Ile Asn His Gly Val Ser Arg Asp Leu Thr Asp 
65                  70                  75                  80  


Gln Thr Met Ala Val Phe Lys Glu Phe Phe Ala Ser Pro Ala Glu Leu 
                85                  90                  95      


Lys Ala Lys Phe Tyr Ser Asn Asp Leu Asn Ser Ser Cys Arg Leu Tyr 
            100                 105                 110         


Thr Ser Thr Leu Asn Tyr Glu Asn Glu Glu Val His Tyr Trp Arg Asp 
        115                 120                 125             


Asn Phe Thr His Arg Cys His Pro Leu Glu Asp His Ile Lys His Trp 
    130                 135                 140                 


Pro Glu Lys Pro Val Asn Tyr Arg Glu Val Val Gly Lys Tyr Ser Ile 
145                 150                 155                 160 


Glu Val Arg Arg Phe Leu Met Lys Ile Leu Gly Leu Ile Cys Asp Gly 
                165                 170                 175     


Met Gly Leu Glu Thr Gly Tyr Leu Glu Gly Glu Met Ser Lys Asn Gln 
            180                 185                 190         


Leu Ile Ser Val Asn His His Ile Pro Cys Pro Asp Pro Ser Leu Thr 
        195                 200                 205             


Leu Gly Met Pro Glu His Ser Asp Pro Asn Leu Ile Ser Met Ile Gln 
    210                 215                 220                 


Gln Gly Asp Ile Cys Gly Leu Gln Ala Leu Lys Asp Gly Gln Trp Ile 
225                 230                 235                 240 


Gly Ile Glu Pro Ile Pro Gly Ala Phe Val Val Ile Pro Gly Leu Gln 
                245                 250                 255     


Leu Arg Val Ile Ser Asn Gly Lys Leu Ala Ser Ile Val His Arg Val 
            260                 265                 270         


Val Thr Asp Ser Lys Glu Ser Arg Thr Thr Ile Gly Thr Phe Leu Thr 
        275                 280                 285             


Pro Ser Asn Asp Ile Leu Ile Lys Pro Ala Asp Gly Leu Leu Gly Ser 
    290                 295                 300                 


Met Ala Pro Met Tyr Arg Gly Tyr Thr Tyr Glu Glu Phe Phe Ser Ile 
305                 310                 315                 320 


Phe Ile Gly Asn Asn Cys Val Ala Glu Arg Ala Leu Glu Cys Leu Lys 
                325                 330                 335     


Leu 
    


<210>  451
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  451

Met Pro Pro Asn Asp Ser Ala Trp Lys Ala Val Pro Glu Met Cys Arg 
1               5                   10                  15      


Ala Ala Phe Ala Asp Trp Asp Lys Ala Val Val Gly Leu Ala Glu Glu 
            20                  25                  30          


Leu Met Ser Ile Leu Cys Glu Gly Met Gly Ile Lys Ser Asp Lys Leu 
        35                  40                  45              


Lys Glu Glu Leu Cys Leu Glu Arg Arg Leu Ser Leu Ser His Tyr Tyr 
    50                  55                  60                  


Pro Gln Cys Pro Gln Pro Glu Leu Ile Leu Gly Leu Thr Ser His Thr 
65                  70                  75                  80  


Asp Pro Cys Val Leu Thr Val Leu Val Gln Asn Glu Val Gly Gly Leu 
                85                  90                  95      


Leu Gln Ile Lys Cys Gly Glu Asp Trp Val Asn Val Asp Pro Val Pro 
            100                 105                 110         


Gly Ala Ile Val Ile Asn Ile Gly Asp Leu Leu Gln Ile Met Ser Asn 
        115                 120                 125             


Asp Glu Tyr Lys Ser Val Glu His Arg Val Leu Ala Asn Thr Glu Glu 
    130                 135                 140                 


Gly Val Arg Val Ser Ile Ala Val Leu Phe Thr Pro Ser Asn Leu Glu 
145                 150                 155                 160 


Lys Ile Tyr Gly Pro Phe Pro Glu Leu Ile Ser Asp Glu Lys Pro Ser 
                165                 170                 175     


Val Tyr Asn Asp Phe Ile Tyr Ser Glu Phe Ile Arg Arg Phe Glu Asn 
            180                 185                 190         


<210>  452
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  452

Met Ala Ile Pro Val Ile Asp Phe Ser Lys Leu Asn Gly Glu Glu Arg 
1               5                   10                  15      


Ala Lys Thr Met Ala Gln Ile Ala Asn Gly Cys Glu Glu Trp Gly Phe 
            20                  25                  30          


Phe Gln Leu Val Asn His Gly Ile Pro Glu Glu Leu Leu Glu Arg Val 
        35                  40                  45              


Lys Lys Val Ser Ser Glu Cys Tyr Lys Arg Glu Arg Glu Glu Glu Phe 
    50                  55                  60                  


Phe Lys Asn Ser Thr Pro Val Lys Leu Leu Arg Glu Leu Val Asp Lys 
65                  70                  75                  80  


Lys Ser Asn Glu Lys Leu Glu Asn Ile Asp Trp Glu Asp Val Phe Leu 
                85                  90                  95      


Leu Ser Asp Asp Asn Glu Trp Pro Pro Lys Thr Leu Gly Phe Lys Glu 
            100                 105                 110         


Thr Met Thr Glu Tyr Arg Ala Glu Leu Lys Lys Leu Ala Glu Glu Leu 
        115                 120                 125             


Met Val Val Met Asp Glu Asn Leu Gly Ile Pro Lys Gly Tyr Ile Lys 
    130                 135                 140                 


Asn Ala Phe Asn Gly Gly Glu Gly Gln Lys Ala Phe Phe Gly Thr Lys 
145                 150                 155                 160 


Ala Ser Ser Cys Ser Ser Arg Met Lys Arg Trp Pro Asp Gly Leu Gln 
                165                 170                 175     


Ile Leu Lys Gly Gly Glu Trp Ile Asp Val Gln Pro Leu Pro Asn Ser 
            180                 185                 190         


Ile Val Ile Asn Thr Gly Asp Gln Ile Glu Val Leu Ser Asn Gly Arg 
        195                 200                 205             


Tyr Lys Ser Val Trp His Arg Val Asn Ser Lys Arg Asp Gly Thr Arg 
    210                 215                 220                 


Arg Ser Ile Ala Ser Phe Tyr Asn Pro Ser Tyr Asp Ala Thr Ile Ala 
225                 230                 235                 240 


Pro Ala Ser Gln Leu Val Thr Lys Glu Asn Glu Asp Ile Asn Thr Phe 
                245                 250                 255     


Gly Tyr Pro Lys Phe Val Phe Gly Asp Tyr Met Thr Val Tyr Ser Glu 
            260                 265                 270         


Gln Lys Phe Leu Pro Lys Glu Pro Arg Phe His Ala Val Lys Thr Val 
        275                 280                 285             


<210>  453
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  453

Met Leu Pro Val Ile Asp Leu Ser Ser Ser Ser Glu Asp Arg Ile Ser 
1               5                   10                  15      


Thr Ala His Ser Ile Arg Gln Ala Cys Thr Asp Tyr Gly Phe Phe Tyr 
            20                  25                  30          


Leu Ile Asn His Gly Val Asp Glu Gln Leu Leu Gln Asn Val Phe Glu 
        35                  40                  45              


Gln Ser Arg Leu Phe Phe Ser Leu Pro Leu Glu Asp Lys Met Lys Cys 
    50                  55                  60                  


Ser Arg Asn Ile Gly Gly Asp Phe Gly Phe Ser Pro Leu Tyr Ala Glu 
65                  70                  75                  80  


Asn Leu Asp Ser Ser Ser Ser Ser Lys Thr Lys Gly Asp Ser Lys Glu 
                85                  90                  95      


Thr Phe His Ile Gly Pro Leu Gln Asn Gln Leu Asn Gln Trp Pro Ser 
            100                 105                 110         


Gln Asp Leu Leu Pro Ser Trp Arg Ser Val Met Glu Thr Tyr Tyr Thr 
        115                 120                 125             


Ser Leu Leu Ser Ile Gly Lys Lys Leu Ser Ser Leu Ile Ala Leu Ala 
    130                 135                 140                 


Leu Asn Leu Asp Asp His Phe Phe His Ser Ile Gly Ala Leu Asp Lys 
145                 150                 155                 160 


Pro Tyr Ala Phe Leu Arg Leu Leu His Tyr Pro Gly Glu Met Gly Asp 
                165                 170                 175     


Ser Asp Glu Asp Gly Val Val Tyr Gly Ala Ser Ala His Ser Asp Tyr 
            180                 185                 190         


Gly Met Ile Thr Leu Leu Ala Thr Asp Gly Val Pro Gly Leu Gln Val 
        195                 200                 205             


Cys Arg Glu Lys Leu Lys His Pro Arg Thr Trp Glu Asn Val Asn His 
    210                 215                 220                 


Val Lys Gly Ala Phe Ile Val Asn Leu Gly Asp Leu Met Glu Arg Trp 
225                 230                 235                 240 


Thr Asn Cys Leu Phe Arg 
                245     


<210>  454
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  454

Met Pro Pro Asn Asp Ser Ala Trp Lys Ala Val Pro Glu Met Cys Arg 
1               5                   10                  15      


Ala Ala Phe Ala Asp Trp Asp Lys Ala Val Val Gly Leu Ala Glu Glu 
            20                  25                  30          


Leu Met Ser Ile Leu Cys Glu Gly Met Gly Ile Lys Ser Asp Lys Leu 
        35                  40                  45              


Lys Glu Glu Leu Cys Leu Glu Arg Arg Leu Ser Leu Ser His Tyr Tyr 
    50                  55                  60                  


Pro Gln Cys Pro Gln Pro Glu Leu Ile Leu Gly Leu Thr Ser His Thr 
65                  70                  75                  80  


Asp Pro Cys Val Leu Thr Val Leu Val Gln Asn Glu Val Gly Gly Leu 
                85                  90                  95      


Leu Gln Ile Lys Cys Gly Glu Asp Trp Val Asn Val Asp Pro Val Pro 
            100                 105                 110         


Gly Ala Ile Val Ile Asn Ile Gly Asp Leu Leu Gln Ile Met Ser Asn 
        115                 120                 125             


Asp Glu Tyr Lys Ser Val Glu His Arg Val Leu Ala Asn Thr Glu Glu 
    130                 135                 140                 


Gly Val Arg Val Ser Ile Ala Val Leu Phe Thr Pro Ser Asn Leu Glu 
145                 150                 155                 160 


Lys Ile Tyr Gly Pro Phe Pro Glu Leu Ile Ser Asp Glu Lys Pro Ser 
                165                 170                 175     


Val Tyr Asn Asp Phe Ile Tyr Ser Glu Phe Ile Arg Arg Phe Glu Ile 
            180                 185                 190         


Lys Glu Leu Ala Gly Lys Arg Lys Thr Asp Phe Cys Arg Ile Ala Asn 
        195                 200                 205             


Thr Asn Lys Arg 
    210         


<210>  455
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  455

Met Val Leu Asp Asn Thr Ser Leu Thr Lys Pro Asn Tyr Asp Arg Lys 
1               5                   10                  15      


Ala Glu Leu Lys Ala Phe Asp Glu Thr Lys Thr Gly Val Lys Gly Leu 
            20                  25                  30          


Val Asp Ala Gly Ile Thr Gln Val Pro Arg Ile Phe His Val Pro Ser 
        35                  40                  45              


Pro Gln Asn Leu Asn Ser Asn Gln Pro Cys Pro Lys Pro Ser Leu Pro 
    50                  55                  60                  


Ile Ile Asp Leu Glu Gly Ile Asn Glu Asp Pro Ile Lys Arg Glu Lys 
65                  70                  75                  80  


Val Val Lys Glu Val Asn Asp Ala Leu Glu Ser Trp Gly Phe Phe Gln 
                85                  90                  95      


Ile Val Asn His Gly Ile Ser Asn Ser Thr Leu Glu Glu Val Lys Lys 
            100                 105                 110         


Gly Val Arg Gly Phe Phe Glu Gln Asp Asp Glu Val Lys Lys Glu Trp 
        115                 120                 125             


Tyr Thr Arg Asp Ser Ser Gly Asn Arg Arg Val Val Tyr Asn Ser Asn 
    130                 135                 140                 


Phe Asp Leu Tyr Val Ala Pro Val Thr Asn Trp Arg Asp Thr Phe Ile 
145                 150                 155                 160 


Cys Arg Met Ala Pro Asn Pro Pro Glu Pro His Glu Leu Pro Gln Pro 
                165                 170                 175     


Cys Arg Asp Ile Trp Pro Lys Tyr Ser Ser Gln Val Leu Lys Leu Gly 
            180                 185                 190         


Gly Cys Val Phe Glu Leu Ile Ser Glu Ala Leu Gly Leu Asn Pro Asn 
        195                 200                 205             


His Leu Leu Asp Met Gly Cys Ala Glu Gly Leu Ala Val Leu Gly His 
    210                 215                 220                 


Tyr Tyr Pro Ser Cys Pro Gln Pro Glu Leu Ala Ile Gly Thr Pro Asn 
225                 230                 235                 240 


His Ala Asp Asn Ser Phe Ile Thr Ile Leu Leu Gln Asp His Val Gly 
                245                 250                 255     


Gly Leu Gln Val Phe Tyr Gln Asp Gln Trp Thr Asp Val Pro Pro Ile 
            260                 265                 270         


Pro Gly Ala Leu Val Val Asn Ala Gly Asp Leu Leu Gln Ala Ser Leu 
        275                 280                 285             


Phe Pro Ser Leu Ile Thr Asn Asp Lys Phe Val Ser Ala Gln His Lys 
    290                 295                 300                 


Val Leu Ala Asn Lys Ile Gly Pro Arg Val Ser Val Ala Ser Phe Phe 
305                 310                 315                 320 


Ser Thr Asn Thr Ile Pro Thr Leu Lys Val Phe Glu Pro Ile Lys Glu 
                325                 330                 335     


Leu Leu Ser Glu Asp Asn Pro Pro Lys Tyr Arg Gly Thr Thr Val Lys 
            340                 345                 350         


Glu Tyr Val Asp Tyr Tyr Arg Gly Lys Gly Leu Asp Gly Thr Ser Ala 
        355                 360                 365             


Leu Leu His Phe Lys Ile 
    370                 


<210>  456
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  456

Met Val Leu Leu Ser Thr Ser Pro Phe Pro Gln Lys Tyr Asp Arg Lys 
1               5                   10                  15      


Ala Glu Leu Thr Ala Phe Asp Glu Ala Lys Thr Gly Val Lys Gly Leu 
            20                  25                  30          


Val Glu Ala Gly Ile Thr Glu Val Pro Arg Ile Phe His Met Pro Ser 
        35                  40                  45              


Pro Gln Asn Leu Asn Ser Asn Gln Glu Ser His Ser Lys Leu Cys Pro 
    50                  55                  60                  


Pro Thr Ile Asp Leu Glu Gly Ile His Glu Asp Pro Ile Lys Arg Lys 
65                  70                  75                  80  


Glu Val Ile Lys Gln Val Lys Asp Ala Phe Glu Thr Trp Gly Cys Phe 
                85                  90                  95      


Gln Met Val Asn His Gly Ile Pro Leu Ser Ile Leu Glu Glu Met Met 
            100                 105                 110         


Glu Gly Val Lys Arg Phe His Glu Asp Asp Val Glu Val Arg Lys Gln 
        115                 120                 125             


Trp Tyr Lys Arg Asn Gly Gly Gly Lys Arg Arg Val Val Tyr Asn Thr 
    130                 135                 140                 


Asn Phe Asp Leu Tyr Thr Ala Pro Met Ala Asn Trp Arg Asp Thr Phe 
145                 150                 155                 160 


Tyr Val Thr Met Ala Pro Asn Pro Pro Gln Pro Asp Glu Leu Pro Pro 
                165                 170                 175     


Gln Cys Arg Asp Ile Leu Leu Val Tyr Ser Ser Gln Met Met Lys Leu 
            180                 185                 190         


Ser Ser Cys Met Phe Glu Leu Ile Ser Glu Ala Leu Gly Leu Asp Pro 
        195                 200                 205             


Asn His Leu Gly Asp Met Gly Cys Ala Glu Gly Leu Ala Val Leu Gly 
    210                 215                 220                 


His Tyr Tyr Pro Ser Cys Pro Gln Pro Glu Leu Thr Leu Gly Thr Ser 
225                 230                 235                 240 


Pro His Ser Asp Thr Ser Leu Ile Thr Ile Leu Leu Gln Asp His Val 
                245                 250                 255     


Gly Ala Leu Gln Thr Leu Tyr Gln Asn Gln Trp Thr Asp Ile Pro Pro 
            260                 265                 270         


Ile Pro Gly Ala Leu Val Val Asn Ala Gly Asp Ile Leu Gln Leu Ile 
        275                 280                 285             


Thr Asn Asp Gln Phe Ile Ser Ala Glu His Lys Val Leu Ala Lys Lys 
    290                 295                 300                 


Val Gly Pro Arg Ile Ser Val Ala Ser Asn Ile Ser Thr Gly Leu Val 
305                 310                 315                 320 


Glu Thr Gly Lys Ile Phe Glu Pro Ile Lys Glu Leu Leu Ser Glu Asp 
                325                 330                 335     


Asn Pro Ala Lys Tyr Arg Gly Thr Thr Val Thr Glu Tyr Val Asn Tyr 
            340                 345                 350         


Tyr Arg Lys Lys Gly Leu Asp Gly Ile Ser Ser Leu Leu His Phe Lys 
        355                 360                 365             


Ile 
    


<210>  457
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  457

Met Leu Thr Gln Tyr Arg Ser Cys Leu Ile Val Asp Leu Leu Pro Phe 
1               5                   10                  15      


Tyr Ala Arg Asp Thr Asn Glu Glu Tyr Ala Gln Asn Leu Ile Gly Val 
            20                  25                  30          


Ala Asn Lys Leu Leu Gly Leu Leu Ser Lys Gly Leu Gly Leu Glu Glu 
        35                  40                  45              


Asp Glu Val Lys Gln Ala Leu Gly Gly Glu Asp Leu Val Tyr Met Leu 
    50                  55                  60                  


Lys Ile Asn Tyr Tyr Pro Pro Cys Pro Cys Pro Glu Leu Ala Leu Gly 
65                  70                  75                  80  


Val Ala Pro His Thr Asp Met Ser Ser Ile Thr Ile Leu Val Pro Asn 
                85                  90                  95      


Glu Val Gln Gly Leu Gln Val Phe Lys Asp Gly Asp Trp Tyr Asp Val 
            100                 105                 110         


Ala Tyr Ile Pro Asn Ala Leu Ile Ile His Ile Gly Asp Gln Ile Glu 
        115                 120                 125             


Ile Leu Ser Asn Gly Lys Tyr Lys Ser Val Tyr His Arg Thr Thr Val 
    130                 135                 140                 


Asn Lys Glu Lys Thr Arg Met Ser Trp Pro Val Phe Leu Glu Pro Pro 
145                 150                 155                 160 


Pro Glu Phe Glu Val Gly Pro Ile Pro Lys Leu Val Asn Lys Asp Asp 
                165                 170                 175     


Pro Pro Lys Tyr Lys Thr Lys Lys Tyr Lys Asp Tyr Val Tyr Cys Lys 
            180                 185                 190         


Leu Asn Lys Leu Pro Gln 
        195             


<210>  458
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  458

Met Ser Ile Asn Glu Glu Tyr His Gly Ser His Phe His Glu Ala Thr 
1               5                   10                  15      


Phe Ile Asn Gln Asn Gly Glu Leu Gln Thr Ser Lys Ile Pro Val Val 
            20                  25                  30          


Gln Glu Leu Ala Arg Glu Gly Leu Thr Asn His Phe Pro Lys Arg Phe 
        35                  40                  45              


Ile Ser Leu Pro Gln Glu Gly Gln Ser Ile Asp Thr Ile Ile Leu Glu 
    50                  55                  60                  


Thr Pro Pro Val Ile Asp Ile Ala Lys Leu Lys His Asn Asp Thr Arg 
65                  70                  75                  80  


Lys Met Glu Leu Ile Lys Leu Ala Glu Ala Ala Lys Glu Trp Gly Val 
                85                  90                  95      


Phe Leu Ile Lys Asn His Gly Val Asp Asp Thr Val Leu Asp Asp Val 
            100                 105                 110         


Lys Asp Val Val Lys Gly Phe Phe Ala Leu Ser Phe Glu Glu Lys Lys 
        115                 120                 125             


Val Asn Val Gly Thr Tyr Arg Ser Val Asp Asn Met Gly Gln Ser Ile 
    130                 135                 140                 


Glu Lys Tyr Val Glu Lys Ser Arg Lys Val Leu Asp Val Leu Leu Glu 
145                 150                 155                 160 


Asp Leu Ala Glu Ser Leu Ser Leu Asp Lys Asn Ala Phe Leu Gln Tyr 
                165                 170                 175     


Phe Glu Pro Gln Gln Ser Glu Ile Lys Val Arg Val Asn Tyr Tyr Pro 
            180                 185                 190         


Pro Cys Pro Arg Pro Asp Leu Ala Ile Gly Ile Leu Pro His Ser Asp 
        195                 200                 205             


Pro Ser Gly Leu Thr Leu Leu Leu Glu Phe Gly Ala Thr Gly Ser Leu 
    210                 215                 220                 


Gln Val His Lys Asp Thr Cys Trp Ala Thr Leu Gln Trp Pro Asn Asn 
225                 230                 235                 240 


Asn Asn Leu Leu Val Asn Ile Gly Asp Leu Leu Glu Ile Met Ser Asn 
                245                 250                 255     


Gly Met Leu Lys Ser Ala Trp His Arg Val Arg Thr Gln Leu Asn Ala 
            260                 265                 270         


Glu Arg Ile Ser Leu Ala Tyr Phe Tyr Asn Pro Pro Pro Gln Cys Glu 
        275                 280                 285             


Ile Gly Pro Leu Val Asn Ser Asp Ser Met Glu Glu Ile Tyr Lys Lys 
    290                 295                 300                 


Val Val Val Glu Asp Tyr Val Ser His Leu Tyr Lys Ile Ser Pro Thr 
305                 310                 315                 320 


Thr Ser Lys Glu Ala Ile Met Tyr Ala Lys Val Lys 
                325                 330         


<210>  459
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  459

Met Ala Asn Lys Lys Ile Glu Gly Met Glu Thr Glu Phe Ala Gln Phe 
1               5                   10                  15      


Arg Thr Glu Ile Asn Thr Arg Phe Ala Glu Ile Asn Asp Lys Phe Ala 
            20                  25                  30          


Ala Met Gln Gln Glu Asn Lys Ala Met Gln Gln Glu Asn Met Ala Met 
        35                  40                  45              


Gln Glu Ala Asn Thr Lys Arg Leu Asp Asp Val Met Lys Ala Leu Ala 
    50                  55                  60                  


Ala Leu Thr Thr Ser Thr Ser Lys Ile Gln Pro Lys Asn Glu Lys Lys 
65                  70                  75                  80  


Asn Thr Gly Pro Gln Tyr Asp Asp Phe Glu Phe Leu Met Asn His Arg 
                85                  90                  95      


Asn Leu Asn Glu Thr Phe Asp Pro Lys Lys Lys Val Glu Gly Val Val 
            100                 105                 110         


Phe Gln Asp Lys Asn Ser Ser Val Phe Arg Val Gly Ser Gly Ser Asn 
        115                 120                 125             


Gly Ile Glu Asn His Tyr Thr Gly Gly Ser Lys Arg Gly Ser Phe Glu 
    130                 135                 140                 


Ala Asp Phe Arg Phe Arg Lys Leu Lys Met Pro Ile Phe Glu Gly Glu 
145                 150                 155                 160 


Asp Ala His Gly Trp Ile Tyr Arg Met Glu Arg Tyr Phe Asp Ile Gln 
                165                 170                 175     


Glu Ile Gln Glu Met Asp Gln Leu Trp Ala Ala Val Leu Cys Met Glu 
            180                 185                 190         


Gly Pro Pro Tyr His Gly Ile Val Gly Val Arg Glu Gly Leu Arg Leu 
        195                 200                 205             


Gly Leu Gly Lys Gly Ile Ala Gln Asp Asp Thr Gly Arg Glu Tyr Val 
    210                 215                 220                 


Ala Leu Phe Glu Arg Leu Ala Cys Gln Leu Val Gly Ile Ser Glu Pro 
225                 230                 235                 240 


Val Leu Gln Gly Thr Phe Ile Asn Gly Leu Lys Pro Glu Leu Arg Ala 
                245                 250                 255     


Ser Val His Val Met Gln Pro Glu Val Leu Asn His Ala Met Lys Leu 
            260                 265                 270         


Ser Ile Ser Ile Asp Glu Asn Lys Thr Cys Tyr Asn Val Leu Trp Gly 
        275                 280                 285             


Ala Ile Pro Lys Pro Pro Val Glu Leu Phe Phe Thr Lys Ser Ser Lys 
    290                 295                 300                 


Gln Asn Asn Asn His His Ala Lys Asp Phe Ile Thr Ile Pro Ile Ile 
305                 310                 315                 320 


Asp Leu Ser Lys Pro Val Ser Lys His Leu Leu Val Lys Ala Arg Gln 
                325                 330                 335     


Asp Phe Gly Phe Phe Lys Ala Gly Pro Pro Asn Pro Phe Gly Tyr Gly 
            340                 345                 350         


Asn Lys Arg Leu Gly Lys Asn Gly Asp Phe Gly Trp Val Glu Tyr Leu 
        355                 360                 365             


Leu Leu Asp Thr Lys Leu Glu His Asp His Lys Asn Pro Ile Phe Pro 
    370                 375                 380                 


Ile Phe Glu Asp Asn Pro Lys Lys Phe Lys Cys Val Val Asp Asp Tyr 
385                 390                 395                 400 


Val Ser Val Val Lys Lys Met Ala Cys Val Ile Leu Val Phe Leu Ala 
                405                 410                 415     


Asp Glu Leu Lys Leu Pro Gln Asn Asp Phe Ser Lys Met Leu Met Asp 
            420                 425                 430         


Glu Gln Ser Asp Ser Val Phe Arg Val Asn Tyr Tyr Pro Pro Cys Pro 
        435                 440                 445             


Asp Val Gln Glu Leu Glu Met Lys Gly Lys Lys Leu Ile Gly Phe Gly 
    450                 455                 460                 


Glu His Thr Asp Pro Gln Ile Ile Ser Phe Leu Gln Ser Asn Asn Thr 
465                 470                 475                 480 


Thr Gly Leu Glu Ile Leu Leu Lys Asp Gly Ser Trp Met Cys Val Pro 
                485                 490                 495     


Pro Asp Pro Asn Ser Phe Phe Val Asn Val Gly Asp Cys Leu Gln Val 
            500                 505                 510         


Gln Ala Leu Ile His Glu Lys Val Met Thr Asn Gly Arg Phe Lys Ser 
        515                 520                 525             


Val Lys His Arg Val Val Ala Asn Ser Leu Lys Ser Arg Leu Ser Met 
    530                 535                 540                 


Ile Tyr Phe Gly Gly Pro Pro Leu Ser Gln Lys Ile Ala Pro Leu Pro 
545                 550                 555                 560 


Ser Leu Met Glu Gly Asp Asp Val Ile Leu Tyr Lys Glu Phe Thr Trp 
                565                 570                 575     


Phe Glu Tyr Lys Lys Ser Ala Phe Ser Ser Arg Leu Ser Asp Asn Arg 
            580                 585                 590         


Leu Ser Leu Tyr Glu Lys Asp His Lys Val Leu Ser 
        595                 600                 


<210>  460
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  460

Met Asp Ala Tyr Gln Asn Glu Met Lys Leu Leu Thr Gln Lys Leu Leu 
1               5                   10                  15      


His Leu Met Leu Gln Thr Leu Asn Val Thr Gln Glu Glu Met Asn Trp 
            20                  25                  30          


Ala Ile Ser Ala Arg Asp Ser Gln Thr Lys Leu Gln Leu Asn Ser Tyr 
        35                  40                  45              


Pro Pro Cys Pro Asn Pro Ser Asn Ser Ile Gly Leu Ala Pro His Thr 
    50                  55                  60                  


Asp Thr Leu Leu Leu Thr Leu Leu His Gln Gly Gly Ala Asn Gly Leu 
65                  70                  75                  80  


Glu Ile Phe Val Glu Gly Leu Gly Trp Ser Pro Val Asn Pro Val Asp 
                85                  90                  95      


Gly Ala Phe Val Val Asn Ile Gly Asp Leu Leu His Ile Leu Ser Asn 
            100                 105                 110         


Ala Thr Phe Gln Ala Val Asn His Arg Val Arg Val Asn Lys Ala Lys 
        115                 120                 125             


Gln Arg Ile Ser Val Ala Tyr Phe His Gly Pro Pro Val Glu Ser Val 
    130                 135                 140                 


Val Ala Pro Ser Ser Ser Phe Glu Asn Pro Cys Phe Arg Ser Met Leu 
145                 150                 155                 160 


Leu Val Glu Ala Leu Lys Ser Thr Val Met Glu Pro Leu Leu Glu Ser 
                165                 170                 175     


Val Asn Ser Ile Ile Gly Cys Gln Lys Ile Asp Leu Tyr Phe Glu Ala 
            180                 185                 190         


Asp Cys Asn Tyr Ile Glu Lys Ala Cys Val Leu Val Leu Glu Tyr Ile 
        195                 200                 205             


Ala Ala Lys Asp His Lys Ser Ala Asn Asp Val Arg Asn Glu Asp Asp 
    210                 215                 220                 


Asp His Lys Thr Thr Lys Phe Arg Arg Leu Val Ser Val Asn Pro Ile 
225                 230                 235                 240 


Lys Val Ala Leu Ile Thr Gly Ile Thr Gly Gln Asp Gly Ser Tyr Leu 
                245                 250                 255     


Thr Glu Leu Leu Leu Ser Lys Gly Tyr Ser Val His Gly Leu Ile Arg 
            260                 265                 270         


Arg Ser Ser Asn Phe Asn Thr Gln Arg Ile Asn His Ile Tyr Ile Asp 
        275                 280                 285             


Pro His Asn Ala His Lys Ala Arg Met Lys Leu His Tyr Ala Asp Leu 
    290                 295                 300                 


Thr Asp Ala Ser Ser Leu Arg Arg Trp Ile Asp Thr Ile Ala Pro Asp 
305                 310                 315                 320 


Glu Ile Tyr Asn Leu Ala Ala Gln Ser His Val Ala Val Ser Phe Glu 
                325                 330                 335     


Ile Pro Asp Tyr Thr Ala Asp Val Val Ala Thr Gly Ser Leu Arg Leu 
            340                 345                 350         


Leu Glu Ala Leu Arg Ser His Ile Ser Ala Thr Gly Arg Lys Gly Val 
        355                 360                 365             


Lys Tyr Tyr Gln Ala Gly Ser Ser Glu Met Phe Gly Ser Thr Pro Pro 
    370                 375                 380                 


Pro Gln Ala Glu Asp Thr Pro Phe His Pro Arg Ser Pro Tyr Ala Ala 
385                 390                 395                 400 


Ser Lys Val Ala Ala His Trp Tyr Thr Val Asn Tyr Arg Glu Ala Tyr 
                405                 410                 415     


Gly Ile Tyr Ala Cys Asn Gly Ile Leu Phe Asn His Glu Ser Pro Arg 
            420                 425                 430         


Arg Gly Glu Asn Phe Val Thr Arg Lys Ile Thr Arg Ala Val Gly Arg 
        435                 440                 445             


Ile Lys Ile Gly Leu Gln Asn Lys Leu Phe Leu Gly Asn Leu Gln Ala 
    450                 455                 460                 


Ser Arg Asp Trp Gly Phe Ala Gly Asp Tyr Val Glu Ala Met Trp Leu 
465                 470                 475                 480 


Met Leu Gln Gln Glu Lys Pro Asp Asp Tyr Val Val Ala Thr Glu Glu 
                485                 490                 495     


Ser His Thr Val Glu Glu Phe Leu Glu Lys Ala Phe Gly Tyr Val Gly 
            500                 505                 510         


Leu Asn Trp Lys Asp His Val Glu Ile Asp Lys Arg Tyr Phe Arg Pro 
        515                 520                 525             


Thr Glu Val Asp Asn Leu Lys Gly Asp Ser Thr Lys Ala Arg Lys Val 
    530                 535                 540                 


Leu Gly Trp Lys Pro Lys Val Gly Phe Glu Gln Leu Val Lys Met Met 
545                 550                 555                 560 


Val Asp Glu Asp Ile Glu Leu Ala Lys Arg Glu Lys Val Leu Val Asp 
                565                 570                 575     


Ala Gly Tyr Met Asp Ala Gln Gln Gln Pro 
            580                 585     


<210>  461
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  461

Met Arg Met Asn Tyr Tyr Pro Pro Cys Pro Gln Pro Glu Gln Val Ile 
1               5                   10                  15      


Gly Leu Thr Pro His Ser Asp Ala Val Gly Ile Thr Phe Leu Leu Glu 
            20                  25                  30          


Leu Asn Glu Val Pro Gly Leu Gln Ile Arg Lys Asn Asp Ile Trp Ile 
        35                  40                  45              


Pro Val Lys Pro Leu Pro Asn Ala Phe Ile Val Asn Ile Gly Glu Ile 
    50                  55                  60                  


Leu Glu Ile Val Thr Asn Gly Gln Tyr Lys Ser Val Glu His Arg Ala 
65                  70                  75                  80  


Ile Val Asn Ser Glu Lys Glu Arg Leu Ser Ile Ala Thr Phe Leu Asn 
                85                  90                  95      


Pro Lys Leu Asp Gly Asp Leu Gly Pro Ala Pro Ser Leu Ile Thr Pro 
            100                 105                 110         


Lys Thr Pro Pro Lys Phe Thr Arg Val Ala Val Val Asp Phe Phe Lys 
        115                 120                 125             


Asn Leu Phe Ser Arg Glu Leu Asn Arg Lys Thr Asn Leu Glu Gln Tyr 
    130                 135                 140                 


Tyr Val 
145     


<210>  462
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  462

Met Leu Leu Asn Thr Ser Pro Ile Gln Asn Tyr Asp Arg Lys Ala Glu 
1               5                   10                  15      


Leu Lys Glu Phe Asp Glu Thr Lys Thr Gly Val Lys Gly Leu Val Asp 
            20                  25                  30          


Ala Gly Ile Thr Gln Val Pro Arg Ile Phe His Val Pro Ser Pro Gln 
        35                  40                  45              


Asn His Arg Asn Ser Ile Glu Pro Ser Leu Ser Lys Pro Ser Leu Pro 
    50                  55                  60                  


Thr Ile Asp Leu Glu Gly Ile Asp Glu Asp Pro Ile Lys Arg Lys Lys 
65                  70                  75                  80  


Val Ile Lys Glu Val Asn Asp Ala Leu Glu Ser Trp Gly Phe Phe Gln 
                85                  90                  95      


Ile Val Asn His Gly Ile Ser Asn Gly Thr Leu Glu Lys Val Lys Lys 
            100                 105                 110         


Gly Val Arg Gly Phe Phe Glu Gln Asp Asp Glu Val Lys Lys Glu Trp 
        115                 120                 125             


Tyr Thr Arg Asp Tyr Leu Ser Gly Asn Arg Arg Val Val Tyr Asn Ser 
    130                 135                 140                 


Asn Phe Asp Leu Tyr Ala Ala Pro Val Thr Asn Trp Arg Asp Thr Phe 
145                 150                 155                 160 


Phe Cys Ser Met Ala Pro Asn Pro Pro Glu Pro His Glu Leu Pro Gln 
                165                 170                 175     


Pro Cys Arg Asp Ile Trp Pro Lys Tyr Ser Ser Gln Val Leu Lys Leu 
            180                 185                 190         


Gly Gly Cys Val Phe Glu Leu Ile Ser Glu Ala Leu Gly Leu Lys Pro 
        195                 200                 205             


Ser His Leu Leu Asp Met Gly Cys Ala Glu Gly Leu Ala Val Leu Gly 
    210                 215                 220                 


His Tyr Tyr Pro Ser Cys Pro Gln Pro Glu Leu Thr Ile Gly Ala Pro 
225                 230                 235                 240 


Asn His Ala Asp Asn Ser Phe Ile Thr Ile Leu Leu Gln Asp His Val 
                245                 250                 255     


Gly Gly Leu Gln Val Phe Tyr Gln Asp Gln Trp Thr Asp Val Pro Pro 
            260                 265                 270         


Ile Pro Gly Ala Leu Val Val Asn Ala Gly Asp Leu Leu Gln Ala Ser 
        275                 280                 285             


Leu Tyr Leu Pro Leu Ser Leu Ser His Tyr Thr Ile Ser Phe Cys Trp 
    290                 295                 300                 


Thr Leu Ile Thr Asn Asp Lys Phe Val Ser Ala Gln His Lys Val Leu 
305                 310                 315                 320 


Ala Asn Lys Ile Gly Pro Arg Val Ser Val Ala Ser Phe Phe Ser Thr 
                325                 330                 335     


Ser Ala Ile Pro Thr Leu Lys Val Phe Glu Pro Ile Lys Glu Leu Leu 
            340                 345                 350         


Ser Glu Asp Asn Pro Pro Lys Tyr Arg Gly Thr Thr Val Lys Glu Tyr 
        355                 360                 365             


Val Asp Tyr Tyr Arg Gly Lys Gly Leu Asp Ala Thr Leu Asn Ala Asn 
    370                 375                 380                 


Val Thr Ile Phe Gly Gln Leu Phe His Val Ser Ile Trp Val Glu Phe 
385                 390                 395                 400 


Pro Thr Asp Arg Gln Asn Ile His Pro Ala Thr Asp Ile Lys Glu Trp 
                405                 410                 415     


Pro Gln Trp Pro Gln Pro Met Ser Ile Ser Val Val Met Gln Ala Arg 
            420                 425                 430         


Pro Lys Val Ser Val Pro Leu Cys Gln Ala Leu Gly Lys Leu Leu Arg 
        435                 440                 445             


Lys Tyr Glu Gly Leu Glu Val Arg Phe Lys Gln Thr Gln Glu Ile Leu 
    450                 455                 460                 


Lys Val Glu Ile Asp Val Ser Glu Glu Glu Glu Lys Asn Lys Glu Ile 
465                 470                 475                 480 


Glu Ala Lys Glu Asp Glu Asp Val Ile Glu Val Leu Asp Val Glu Lys 
                485                 490                 495     


His Arg Lys Lys Lys Ala Lys Ala Tyr Gln Thr Leu Arg Ala Arg Ala 
            500                 505                 510         


Thr Ala Val Pro Leu Phe Glu Val Met Arg Asn Phe Pro Val Ser Glu 
        515                 520                 525             


Ile Pro Thr Lys Leu Ala Cys Phe Met Ile Asn Ser Leu Gln Thr Asp 
    530                 535                 540                 


Ser Met Asn Leu Met Leu Pro Val Glu Asn Ile Cys Ile Thr Pro Glu 
545                 550                 555                 560 


Thr Met Lys Val Met Phe Trp His Thr Asp Gly Ser Leu Val Val Lys 
                565                 570                 575     


Tyr Gln Val Leu Lys Asn Val Leu Glu Asp Asp Asp Val Gln Asp Ile 
            580                 585                 590         


Asp Trp Leu Thr Tyr Ile Ser Lys Cys Ala Arg Tyr Ser Lys Tyr Asp 
        595                 600                 605             


Trp Asn Lys Leu Lys Lys Asn Lys Glu Val Val Tyr Tyr Gly Pro Val 
    610                 615                 620                 


Thr Phe Leu Met Leu Val Tyr Leu His Tyr Thr Lys Phe Glu Asn Met 
625                 630                 635                 640 


Glu Val Trp Arg Lys Val Pro Ala Phe Lys Ser Trp Asn Ala Asn Leu 
                645                 650                 655     


Met Lys Arg Arg Glu Met Leu Val Met Gln Arg Asn Asn Phe Gly Leu 
            660                 665                 670         


Val Glu Leu Ile Gly Asp Ile Asn Glu Glu Lys Glu Asn Val Gln Lys 
        675                 680                 685             


Glu Glu Leu Tyr Ile Glu Asp Lys Ile Glu Asn Ile Leu Ser Glu Lys 
    690                 695                 700                 


Glu Gly Leu Ser Asn Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
705                 710                 715                 720 


Asp Asp Asp Asp Asp Asp Asp Ala Gln His Ala Asn Gln Tyr Val Glu 
                725                 730                 735     


Gln Cys Asn Glu Asn Ala 
            740         


<210>  463
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  463

Met Ser Ser Ile Thr Ile Leu Val Pro Asn Glu Val Gln Gly Leu Gln 
1               5                   10                  15      


Val Phe Lys Asp Gly Asp Trp Tyr Asp Val Ala Tyr Ile Pro Asn Ala 
            20                  25                  30          


Leu Ile Ile His Ile Gly Asp Gln Ile Glu Ile Leu Ser Asn Gly Lys 
        35                  40                  45              


Tyr Lys Ser Val His His Arg Thr Thr Val Asn Lys Glu Lys Thr Arg 
    50                  55                  60                  


Met Ser Trp Pro Val Phe Leu Glu Pro Pro Pro Glu Phe Glu Val Gly 
65                  70                  75                  80  


Pro Ile Pro Lys Leu Val Asn Lys Asp Asp Pro Pro Lys Tyr Lys Thr 
                85                  90                  95      


Lys Asn Lys Leu Thr Ala Gln Lys Leu Arg Leu Leu Tyr Ser His Phe 
            100                 105                 110         


Gln Asn Thr Ser Val Tyr Asn Ala Lys Cys Lys Val Asn Leu Thr Tyr 
        115                 120                 125             


Phe Thr Ser Ser Leu Leu Ser Asn Thr Phe Phe Phe Ser Lys Cys Thr 
    130                 135                 140                 


Ile Leu His Val Tyr Arg Asp Thr Asn Glu Glu Tyr Ala Gln Ser Leu 
145                 150                 155                 160 


Ile Gly Val Ala Asn Lys Leu Leu Gly Leu Leu Ser Lys Gly Leu Gly 
                165                 170                 175     


Leu Glu Glu Asp Glu Val Lys Gln Ala Leu Gly Gly Glu Asp Leu Val 
            180                 185                 190         


Tyr Met Leu Lys Ile Asn Tyr Tyr Pro Pro Cys Pro Cys Pro Glu Leu 
        195                 200                 205             


Ala Leu Gly Val Ala Pro His Thr Asp Met Ser Ser Ile Thr Ile Leu 
    210                 215                 220                 


Val Pro Asn Glu Val Gln Gly Leu Gln Val Phe Lys Asp Gly Asp Trp 
225                 230                 235                 240 


Tyr Asp Val Ala Tyr Ile Pro Asn Ala Leu Ile Ile His Ile Gly Asp 
                245                 250                 255     


Gln Ile Glu Ile Leu Ser Asn Gly Lys Tyr Lys Ser Val Tyr His Arg 
            260                 265                 270         


Thr Thr Val Asn Lys Glu Lys Thr Arg Met Ser Trp Pro Val Phe Leu 
        275                 280                 285             


Glu Pro Pro Pro Glu Phe Glu Val Gly Pro Ile Pro Lys Leu Val Asn 
    290                 295                 300                 


Lys Asp Asp Pro Pro Lys Tyr Lys Thr Lys Lys Tyr Lys Asp Tyr Val 
305                 310                 315                 320 


Tyr Cys Lys Leu Asn Lys Leu Pro Gln 
                325                 


<210>  464
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  464

Met Ala Ser Pro Asn Leu Leu Ser Gln Ser Asp Arg Ser Val Gln Glu 
1               5                   10                  15      


Leu Ala Lys Thr Phe Lys His Asp Val Pro His Arg Tyr Ile Gln Glu 
            20                  25                  30          


His Arg Glu Pro Thr Phe Val Ser Asn Asn Ala Thr Ser Leu Pro Ser 
        35                  40                  45              


Ile Pro Val Val Asp Met Asn Asp Phe Ile Asn Ile Leu Gly Ser Glu 
    50                  55                  60                  


Asn Asp Gln Leu Lys Asn Leu Arg Ser Val Cys Gln Glu Trp Gly Ile 
65                  70                  75                  80  


Phe Gln Leu Val Asn His Gly Val Asp Lys Leu Leu Val Asp Lys Met 
                85                  90                  95      


Lys Asn Glu Val Val Lys Phe Phe Asp Met Pro Val Glu Glu Lys Leu 
            100                 105                 110         


Arg Tyr Glu Leu Lys Ala Gly Asp Tyr Gln Gly Tyr Gly Gln Thr Ile 
        115                 120                 125             


Leu His Ala Gln Asp Gln Lys Ile Asp Trp Ala Asp Arg Phe Tyr Met 
    130                 135                 140                 


Ile Thr Asn Pro His His Arg Arg Lys Pro Asn Leu Leu Pro Glu Phe 
145                 150                 155                 160 


Pro Pro Ser Leu Arg Asp Thr Met Glu Asn Tyr Leu Gln Glu Leu Gln 
                165                 170                 175     


Lys Leu Ala Met Thr Leu Phe Gly Leu Val Gly Gln Ala Val Asp Ile 
            180                 185                 190         


Asp Asn Gln Glu Met Ile Asp Val Phe Asp Asp Gly Met Gln Ser Val 
        195                 200                 205             


Arg Met Thr Tyr Tyr Pro Pro Cys Pro Gln Pro Asp Leu Val Ile Gly 
    210                 215                 220                 


Leu Thr Pro His Ser Asp Ala Ala Gly Ile Thr Ile Leu Leu Gln Val 
225                 230                 235                 240 


Asn Gly Val Glu Gly Leu Gln Val Lys Arg Asp Gly Val Trp Ile Pro 
                245                 250                 255     


Val Asn Phe Leu Pro Asp Ala Phe Val Val Asn Val Gly Asp Ile Leu 
            260                 265                 270         


Glu Val Arg Pro Pro Pro His Phe Leu Lys Leu Lys Lys Lys Leu 
        275                 280                 285         


<210>  465
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  465

Met Arg Asn Ser Pro Lys Val Tyr Phe Lys Ser Ile Lys His Gly Val 
1               5                   10                  15      


Pro Leu Ala Leu Ile Lys Lys Leu Arg Val Leu Glu Ser Arg Lys Ala 
            20                  25                  30          


Phe Cys Thr Pro Thr Asp Glu Lys His Lys Val Leu Arg Ser Ala Asn 
        35                  40                  45              


Gly Val Thr Gly Tyr Gly Thr Ala Ser Ile Ser Lys Phe Phe Asp Lys 
    50                  55                  60                  


Cys Met Trp His Glu Gly Phe Gly Ile Met Gly Ser Cys Val Glu Asp 
65                  70                  75                  80  


Ala Lys Ile Leu Trp Pro Tyr Asp Tyr Lys Asn Phe Cys Asn Thr Met 
                85                  90                  95      


Asp Ala Tyr Gln Asn Glu Met Lys Leu Leu Thr Gln Lys Leu Leu Leu 
            100                 105                 110         


Leu Ile Leu Gln Thr Leu Asn Val Thr Gln Glu Glu Met Asn Trp Ala 
        115                 120                 125             


Leu Ser Ala Gln Asp Ser Gln Thr Lys Leu Gln Leu Asn Ser Tyr Pro 
    130                 135                 140                 


Ser Cys Pro Asn Pro Ser Asn Ala Ile Gly Leu Ala Pro His Thr Asp 
145                 150                 155                 160 


Thr Leu Leu Leu Thr Leu Leu His Gln Gly Gly Ala Asn Gly Leu Glu 
                165                 170                 175     


Ile Phe Val Glu Gly Leu Gly Trp Ser Pro Val Asn Pro Val Asp Gly 
            180                 185                 190         


Ala Phe Val Val Asn Ile Gly Asp Leu Leu His Ile Leu Ser Asn Ala 
        195                 200                 205             


Ile Phe Gln Ala Val Asn His Arg Val Arg Val Asn Gln Ala Lys Gln 
    210                 215                 220                 


Arg Ile Ser Val Ala Tyr Phe His Gly Pro Pro Val Glu Ser Val Val 
225                 230                 235                 240 


Ala Pro Ser Ser Ser Phe 
                245     


<210>  466
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  466

Met Tyr Pro Lys Phe Leu Lys Glu Leu Gln Lys Lys Ser Arg Gly Val 
1               5                   10                  15      


Ala Asp Ser Arg Glu Arg Gln Leu Pro Val Ile Asp Leu Ser Phe Lys 
            20                  25                  30          


Lys Val Asn Ser Ser Ser Ser Ser Trp Val Ala Thr Ser Ala Lys Val 
        35                  40                  45              


Arg His Ala Leu Glu Glu Tyr Gly Cys Phe Ile Ala Leu Tyr Gly Val 
    50                  55                  60                  


Ser Lys Asp Leu His Asp Ala Ala Phe Ile Ala Ser Gln Glu Val His 
65                  70                  75                  80  


Asp Leu Pro Val Glu Val Lys Val Arg Asn Val Leu Asp Ala Thr Gly 
                85                  90                  95      


Tyr Gly Tyr Ser Gly Glu Lys Leu Ala Lys Met Pro Leu Tyr Glu Arg 
            100                 105                 110         


Leu Ser Ile Glu Asp Ala Ala Thr Ala Glu Gly Ala Glu Arg Phe Thr 
        115                 120                 125             


Lys Leu Met Trp Pro Ser Arg Asn Asp Thr Leu Trp Asp Lys Ser Phe 
    130                 135                 140                 


Met Thr Val Ile His Gln Arg Glu Glu Gly Lys Ser Leu Glu Ile Gln 
145                 150                 155                 160 


Ala Lys Asp Gly Glu Trp Ile Gln Val Asp Leu Ser Pro Ser Ser Phe 
                165                 170                 175     


Ile Val Met Ala Gly Asp Val Cys Met Ala Trp Ser Asn Gly Arg Ile 
            180                 185                 190         


Gln Ala Pro Tyr His Lys Val Met Met Gln Gly Asn Lys Asp Arg Tyr 
        195                 200                 205             


Ser Leu Val Leu Ser Ser Phe Ile Arg Asp Leu Lys Ile Glu Val Pro 
    210                 215                 220                 


Gln Glu Leu Ile Asp Glu Asp His Pro Leu Gln Phe Lys Ala Phe Asp 
225                 230                 235                 240 


His Tyr Glu Tyr Ile Gln Tyr Val Asp Ser Asn Thr Ile Gln Gly Val 
                245                 250                 255     


Arg Leu Gln Asp Ala Ile Lys Ser Tyr Cys Gly Ile 
            260                 265             


<210>  467
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  467

Met Ile Ala Leu Phe Glu Glu Gly Trp Gln Ala Met Arg Met Asn Tyr 
1               5                   10                  15      


Tyr Pro Pro Cys Pro Gln Pro Glu Gln Val Ile Gly Leu Thr Pro His 
            20                  25                  30          


Ser Asp Ala Ala Gly Ile Thr Phe Leu Leu Glu Leu Asn Gln Val Pro 
        35                  40                  45              


Gly Leu Gln Ile Arg Lys Asp Asp Ile Trp Ile Pro Val Lys Pro Leu 
    50                  55                  60                  


Pro Asn Ala Phe Ile Val Asn Ile Gly Glu Ile Leu Glu Ile Val Thr 
65                  70                  75                  80  


Asn Val Gln Tyr Lys Ser Ile Glu His Arg Ala Ile Val Asn Ser Glu 
                85                  90                  95      


Lys Glu Arg Leu Ser Ile Ala Thr Phe Leu Asn Pro Lys Leu Asp Gly 
            100                 105                 110         


Asp Leu Gly Pro Ala Pro Ser Leu Ile Thr Arg Lys Thr Pro Pro Arg 
        115                 120                 125             


Phe Thr Arg Val Thr Val Val Asp Phe Phe Lys Asn Leu Leu Ser Arg 
    130                 135                 140                 


Glu Leu Asn Arg Lys Thr Asn Leu Glu Gln Tyr Tyr Val 
145                 150                 155         


<210>  468
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  468

Met Ser Asn Gly Val Phe Lys Ser Arg Val His Arg Ala Leu Val Asn 
1               5                   10                  15      


Pro Lys Tyr Glu Arg Met Thr Leu Ala Met Phe Cys Met Pro His Thr 
            20                  25                  30          


Glu Lys Gly Ile Gly Pro Phe Leu Glu Lys Val Arg Glu Ser Ser Ile 
        35                  40                  45              


Leu Ile Phe Arg Ser Ser Met Lys Asp Lys Lys Lys Cys Leu Arg Ala 
    50                  55                  60                  


Glu Asp Asp Phe Glu Gly Tyr Gly Asn Asp Val Ile Leu Leu Asp Gln 
65                  70                  75                  80  


Gln Thr Leu Asp Trp Val Asp Arg Leu Ile Ser Leu Leu Asp Gln Asn 
                85                  90                  95      


Thr Asn Lys Ser Phe Asn Phe Gly Leu Lys Ile Leu Leu Thr Ser Val 
            100                 105                 110         


Phe Gly Leu Lys Pro His Ala Asp Gly Thr Ala Ile Thr Val Leu Leu 
        115                 120                 125             


Gln Asp Lys Glu Ile Glu Gly Leu Gln Leu Leu Lys Asp Gly Gln Trp 
    130                 135                 140                 


Val Gly Val Pro Ile Val Arg Asp Ala Leu Thr Ile Asn Val Gly Asp 
145                 150                 155                 160 


Gln Ile Glu Ile Met Ser Asn Gly Val Phe Lys Ser Arg Val His Arg 
                165                 170                 175     


Ala Leu Val Asn Pro Lys Tyr Glu Arg Met Thr Leu Ala Met Phe Cys 
            180                 185                 190         


Met Pro His Thr Glu Lys Gly Ile Gly Pro Val Asp Glu Leu Ile Thr 
        195                 200                 205             


Asp Glu Thr Pro Arg Leu Tyr Lys Asn Val Lys Tyr Ser Leu Asp Phe 
    210                 215                 220                 


Tyr Phe Glu His 
225             


<210>  469
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  469

Met Ala Glu Val Val Pro Phe Asp Leu Val Glu Gln Ile Leu Leu Arg 
1               5                   10                  15      


Leu Gly Val Lys Asp Leu Leu Arg Cys Lys Ser Val Cys Lys Leu Trp 
            20                  25                  30          


Gln Ser Leu Ile Leu Ser Tyr Arg Phe Val Lys Tyr His Met Asn His 
        35                  40                  45              


Ala Asn Asn Lys Asp Asn Asn Asn Lys Glu Ile Gly His Arg Arg Ile 
    50                  55                  60                  


Leu Met Pro Glu Ile Tyr Arg Met Asn Met Ala Tyr Asp Met Trp Tyr 
65                  70                  75                  80  


Tyr Met Asn Ser Trp Gln Ile Val Gly Ser Ser Asn Gly Leu Val Cys 
                85                  90                  95      


Val Thr Pro Val Asp Ala Gln Val Tyr Val Ala Asn Pro Ser Ile Arg 
            100                 105                 110         


Glu Val Lys Asp Leu Pro Thr Pro Pro Ile Cys Ile Arg Asn Glu Glu 
        115                 120                 125             


Asp Arg Lys Asp Leu Cys Trp Gly Phe Gly Tyr Asp Ser Ser Ile Asp 
    130                 135                 140                 


Asp Tyr Lys Val Val Ile Gly Val Val Val Val Val Glu Gly Lys Tyr 
145                 150                 155                 160 


Leu Thr Arg Phe Gln Leu Leu Thr Leu Lys Ser Asn Thr Trp Lys Phe 
                165                 170                 175     


Ile Gly Asp Leu Lys Tyr Thr Ser Phe Ser Thr Phe Ala Ser Leu Cys 
            180                 185                 190         


Asn Gly Ser Leu His Trp Ile Met Lys Asp Ser Ile Thr Lys Lys Trp 
        195                 200                 205             


Ala Ile Ile Ser Phe Asn Leu Ser Gln Glu Lys Phe Lys Glu Ile Ser 
    210                 215                 220                 


Gln Pro Asp Asp Ser Arg Tyr Ala Phe Asp Ser Thr Asp Ile Ser Arg 
225                 230                 235                 240 


Lys Leu Gly Ile Val Glu Gly Cys Leu Cys Ile Phe Asn Val Glu Thr 
                245                 250                 255     


Val Pro Asn Asn Thr Trp Val Met Lys Asn Tyr Asn Val Ser Ser Ser 
            260                 265                 270         


Trp Glu Leu Leu Pro Tyr Asp Cys Leu Tyr Asn Thr Arg Lys Tyr Ile 
        275                 280                 285             


Glu Gln Asp Asp His Met Tyr Arg Cys Ser Tyr Ile Arg Thr Met Tyr 
    290                 295                 300                 


Asp Ile Ala Tyr Lys Pro Ile Phe Asn Ile Gln Pro Asn Asp Val Phe 
305                 310                 315                 320 


Tyr Asn Asp Lys Asp Ile Tyr Leu Ser Lys Thr Thr Ala His Met Gly 
                325                 330                 335     


Asp Pro Ile Phe Val Glu Ser Leu Val Ser Pro His Val Asn Gly Arg 
            340                 345                 350         


Pro Lys Gln Val Tyr Leu Gly Leu Glu Lys Thr Thr Asn Gly Pro Arg 
        355                 360                 365             


Arg Val Val Glu Ser Val Arg Ala Arg Leu Cys Ile Asn Lys Trp Arg 
    370                 375                 380                 


His Pro Trp Asp Leu Thr Thr Thr Ser Phe Val Phe Ser His His Arg 
385                 390                 395                 400 


Asn Ala Thr Ile Glu Phe Lys Ile Arg His Leu Ala Trp Met Glu Ala 
                405                 410                 415     


Asn Tyr Gly Lys Ile Ser Ser Asn Gly Tyr Asn Ser Phe Cys Leu Ile 
            420                 425                 430         


Leu Arg Glu Val Val Arg Lys Ile Ala Arg Leu Ile Ala Leu Ala Leu 
        435                 440                 445             


Asp Leu Glu Ala Asn Phe Phe Asp Arg Pro Glu Phe Leu Gly Arg Pro 
    450                 455                 460                 


Ile Ala Val Leu Arg Leu Leu His Tyr Glu Gly Gln Val Ser Asp Pro 
465                 470                 475                 480 


Thr Lys Gly Met Tyr Gly Ala Gly Ala His Ser Asp Tyr Gly Leu Val 
                485                 490                 495     


Thr Leu Leu Ala Thr Asp Cys Val Ser Gly Leu Gln Ile Cys Lys Asp 
            500                 505                 510         


Lys Asp Ala Lys Pro Gln Val Trp Glu Asp Val Lys Pro Leu Lys Gly 
        515                 520                 525             


Ala Phe Val Val Asn Leu Gly Asp Met Leu Glu Arg Trp Ser Asn Arg 
    530                 535                 540                 


Ile Phe Arg Ser Thr Leu His Arg Val Leu Val Asn Gly Gln Glu Arg 
545                 550                 555                 560 


Tyr Ser Ile Pro Phe Phe Val Glu Pro Ser His Asp Cys Val Val Glu 
                565                 570                 575     


Cys Leu Pro Thr Cys Gln Ser Lys Leu Asn Pro Pro Lys Ile Pro Phe 
            580                 585                 590         


Tyr Leu Met Ser Ile Ala Cys Leu Val Gly Val Val Tyr Ile Ser Thr 
        595                 600                 605             


Val Leu Gly Phe Leu Leu Ser Ser Ala Lys Ser Thr Phe Phe Arg Asp 
    610                 615                 620                 


Ile Gly Ile Pro Met Leu Ile 
625                 630     


<210>  470
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  470

Met His His Phe Ile Leu Arg Thr Met Ile Thr Gln Leu Val Leu Lys 
1               5                   10                  15      


Phe Leu Ser Asn Ser Thr Thr Gly Asp Ser Lys Glu Thr Phe His Ile 
            20                  25                  30          


Gly Pro Leu Asp Gly Glu Glu Ser Leu Gln Asn Gln Trp Pro Ser Lys 
        35                  40                  45              


Glu Leu Leu Pro Ser Trp Arg Phe Val Met Glu Lys Tyr Tyr Lys Met 
    50                  55                  60                  


Leu Leu Ser Thr Gly Lys Arg Leu Ser Ser Leu Ile Ala Leu Ala Leu 
65                  70                  75                  80  


Asn Leu Glu Glu Asp Phe Phe Glu Lys Ile Gly Ala Val Asp Arg Pro 
                85                  90                  95      


Ser Ala Phe Leu Arg Leu Leu His Tyr Pro Gly Asp Met Gly Val Ser 
            100                 105                 110         


Asp Glu Val Val Tyr Gly Ala Ser Ala His Ser Asp Tyr Gly Met Met 
        115                 120                 125             


Thr Leu Leu Ala Thr Asp Ala Val Cys Arg Glu Lys Asn Lys His Pro 
    130                 135                 140                 


Arg Thr Trp Glu Asn Val Thr His Val Lys Gly Ala Phe Ile Val Asn 
145                 150                 155                 160 


Leu Gly Asp Met Met Glu Arg Trp Thr Asn Cys Leu Phe Arg Ser Thr 
                165                 170                 175     


Leu His Arg Val Met Pro Thr Gly Lys Glu Arg Tyr Ser Val Ala Phe 
            180                 185                 190         


Phe Met Asp Pro Asn Pro Asn Cys Ile Val Glu Cys Leu Lys Ser Cys 
        195                 200                 205             


Cys Ser Glu Ser Ser Pro Pro Arg Phe Pro Pro Ile Leu Ser Gly Asp 
    210                 215                 220                 


Tyr Leu Arg Glu Arg Ile His Asp Ala Tyr Ser Asn Val Lys Thr Gln 
225                 230                 235                 240 


Ser Lys Cys Thr Lys Gly Cys Asn Leu Ala Leu Ala Ser Tyr Tyr Val 
                245                 250                 255     


Ala Gln Gly Ser Asn Leu Thr Tyr Ile Ser Arg Ile Phe Ser Leu Ser 
            260                 265                 270         


Ile Thr Glu Ile Leu Lys Tyr Asn Ser Gln Ile Pro Arg Gly Asp Ser 
        275                 280                 285             


Ile Glu Thr Gly Thr Arg Ile Asn Val Pro Phe Ser Cys Leu Cys Leu 
    290                 295                 300                 


Asn Gly Asp Phe Leu Gly His Thr Phe Leu Tyr Gln Thr Gln Val Gly 
305                 310                 315                 320 


Asp Thr Tyr Gly Lys Ile Ala Arg Asp Val Phe Ala Asn Leu Thr Asp 
                325                 330                 335     


Glu Tyr Trp Val Gln Arg Val Asn Ser Phe Ala Pro Ala Phe Ile Pro 
            340                 345                 350         


Asp Phe Ala Tyr Ile Asn Val Thr Val Asn Cys Thr Cys Gly Asn Lys 
        355                 360                 365             


His Val Ser Lys Asp Tyr Gly Leu Phe Val Thr Tyr Pro Leu Gln Pro 
    370                 375                 380                 


Gly Glu Asp Leu Gln Ser Leu Thr Ser Glu Ser Gly Val Gln Thr Thr 
385                 390                 395                 400 


Leu Leu Glu Gln Phe Asn Pro Ser Ser Asn Phe Ser Gly Gly Ser Gly 
                405                 410                 415     


Leu Val Phe Val Pro Ala Lys Ala Leu Cys Ala Ser Val Ala Ser Thr 
            420                 425                 430         


Ile Asp Arg His Lys Met 
        435             


<210>  471
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  471

Met Asn Thr Glu Glu Ala Asn Glu Leu Val Asn His Gly Ile Ser His 
1               5                   10                  15      


Glu Leu Leu Asp Arg Val Glu Arg Met Thr Lys Glu His Tyr Lys Lys 
            20                  25                  30          


Cys Met Glu Val Arg Phe Lys Glu Asn Gly Gly Ser Gln Arg Ile Arg 
        35                  40                  45              


Arg Ile Ser Arg Gly Lys Lys Ala Phe Tyr Gly Ser Lys Ser Thr Ala 
    50                  55                  60                  


Pro Asn Phe Gly Thr Lys Val Ser Asn Tyr Pro Pro Phe Pro Thr Pro 
65                  70                  75                  80  


Asp Leu Ile Lys Gly Leu Arg Ala His Thr Ala Ala Gly Gly Ile Ile 
                85                  90                  95      


Leu Leu Phe Gln Asp Asp Lys Val Ser Gly Leu Gln Leu Leu Lys Asp 
            100                 105                 110         


Val Gln Trp Ile Asn Glu Pro Ala Met Arg His Thr Ile Val Ile Asn 
        115                 120                 125             


Leu Gly Asp Gln Ile Glu Val Ile Thr Asn Gly Lys Cys Lys Ser Val 
    130                 135                 140                 


Leu His Arg Val Ile Ala Gln Thr Asp Gly Thr Lys Met Ser Phe Ala 
145                 150                 155                 160 


Ser Phe Tyr Asn Pro Gly Gly Asp Ala Val Ile Tyr Pro Ala Lys Ile 
                165                 170                 175     


Leu Met Met Glu His Thr 
            180         


<210>  472
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  472

Met Ala Ala Ser Ser Ala Ser Ser Glu Thr Leu Phe Ser Met Thr Ala 
1               5                   10                  15      


Phe Asn His Met Met His Met Lys Leu Ser Ser Ser Asn Tyr Leu Val 
            20                  25                  30          


Trp Arg Glu Gln Met Leu Leu Val Leu Asp Phe His Thr Leu Ser Ala 
        35                  40                  45              


His Val Ala Ala Asp Ala Thr Pro Pro Pro Ala Leu Ile Thr Val Ala 
    50                  55                  60                  


Gly Lys Ser Ser Pro Asn Pro Asp Ala Ala Ala Trp Phe Asp Lys Asp 
65                  70                  75                  80  


Gln Lys Ala Val Leu Leu Ile Lys Ser Ser Leu Thr Glu Glu Ala Ala 
                85                  90                  95      


Ala Glu Val Leu Gly Leu Lys Gly Ala Arg Asp Ile Trp Thr Ala Leu 
            100                 105                 110         


Glu Gln Ala Tyr Ser Asn Ala Ser Val Glu Arg Ile His Ser Leu Arg 
        115                 120                 125             


Asp Ser Leu Arg Leu Ile Lys Lys Gly Arg Gly Ser Ser Arg Gly Arg 
    130                 135                 140                 


Gly Arg Gly Gln Gln Gln Arg Arg Pro Pro His Cys Gln Leu Cys Arg 
145                 150                 155                 160 


Thr Asn Gly His Tyr Ala Ser Ala Cys Pro Glu Leu His Ser Phe Ala 
                165                 170                 175     


Ser Lys Ala Pro Ser Asp Glu Ser Leu Val Lys Ala Phe His Ala Gln 
            180                 185                 190         


Cys His Val Thr Asp Asp Ser Pro Asp Trp Arg Ala Asp Ser Gly Ala 
        195                 200                 205             


Thr Asp Tyr Met Val Pro Pro Thr Asp Ser Val His Asn Ser Thr Pro 
    210                 215                 220                 


Tyr Lys Gly Asn Asn Cys Val Val Phe Gly Asn Gly Ser Ser Gln His 
225                 230                 235                 240 


Ile Asp Leu Ser Ser Leu Val Val Thr Ser Phe Leu Asp Glu Pro Ser 
                245                 250                 255     


Phe Val Ser Thr Val Glu His His Arg Ser Pro Ser Thr Thr Ser Met 
            260                 265                 270         


Pro Ser Ser Asp Thr Asn Met Leu Pro Pro Phe Asn Phe Phe Glu Ala 
        275                 280                 285             


Glu Ser Asn Ala Pro Ala Gln Gln His Val Ser Glu Thr Thr Ser Pro 
    290                 295                 300                 


Val His Glu Pro Thr Met Ser Thr Asp Pro Thr Pro Val Ser Gly Pro 
305                 310                 315                 320 


Glu Asn Ser Ser Pro Asn Thr Ala Thr Ser Ser Gly Pro Ala Ser Ala 
                325                 330                 335     


Ser Val Leu Asp Gln Ser Thr Ser Ala His Pro Met Gln Thr Arg Ser 
            340                 345                 350         


Lys Ala Asp Val Ile Gly Thr Tyr Ser Leu Glu Val Arg Lys Leu Ser 
        355                 360                 365             


Leu Arg Met Leu Glu Leu Ile Cys Glu Gly Leu Gly Leu Glu Arg Gly 
    370                 375                 380                 


Tyr Phe Glu Gly Asp Leu Thr Met Gly Gln Leu Leu Ser Ile Asn His 
385                 390                 395                 400 


Tyr Leu Pro Cys Pro Asp Pro Gly Leu Gly Leu Gly Leu Pro Lys His 
                405                 410                 415     


Ala Asp Pro Asn Ile Ile Thr Val Leu Phe Gln Glu Asn Ile Tyr Gly 
            420                 425                 430         


Leu Gln Val Phe Lys Asp Gln Gln Trp Leu Gly Val Glu Pro Leu Pro 
        435                 440                 445             


His Thr Phe Ala Val Asn Ile Gly His Gln Leu Tyr Val Ile Asn His 
    450                 455                 460                 


Gly Val Ser Gln Asp Leu Met Asp Asn Thr Met Lys Val Ala Lys Asp 
465                 470                 475                 480 


Phe Phe Asn Met Pro Asn Glu Glu Asn Val Lys Leu Tyr Ser Asn Asp 
                485                 490                 495     


Pro Thr Lys Ser Cys Arg Leu Ser Thr Ala Ser Tyr His Tyr Asp Lys 
            500                 505                 510         


Glu His Phe Trp Arg Asp Asn Leu Thr Asn Val Phe Lys Asp Gly Gln 
        515                 520                 525             


Trp Leu Gly Val Glu Pro Leu Pro His Ala Phe Val Val Asn Ile Gly 
    530                 535                 540                 


Tyr Gln Leu Glu Ile Ile Ser Asn Gly Lys Leu Arg Ser Val Ala His 
545                 550                 555                 560 


Arg Ala Val Thr Asn Ser Lys Glu Asp Arg Thr Ser Ile Val Thr Ser 
                565                 570                 575     


Ile Asp Pro Cys Gln Asp Thr Ile Ile Glu Pro Ala Lys Ser Met Ile 
            580                 585                 590         


Asp Thr Gly Ile Pro Leu Tyr Arg Pro Phe Arg Asn Arg Asp Phe Arg 
        595                 600                 605             


Lys Phe Phe Thr Glu Lys Lys Gly Asp Thr Glu Ala Leu Met Ala Ala 
    610                 615                 620                 


Tyr Lys Phe Lys Pro 
625                 


<210>  473
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  473

Met Asn Met Gln Leu Gln Gln Ile Ser Ser Asp Phe Asp Gln Leu Pro 
1               5                   10                  15      


Ala Arg Tyr Val His Lys Glu Tyr Lys Asp Phe Ser Gly Ile Gly Leu 
            20                  25                  30          


Ser His Val Pro Ser Val Asp Val Pro Val Ile Asp Phe Ser Leu Leu 
        35                  40                  45              


Thr Ser Ser Pro Phe Glu Leu Asp Lys Leu Lys Ser Ala Ile Ser Thr 
    50                  55                  60                  


Trp Gly Cys Phe Gln Ala Ile Asn His Gly Thr Glu Gly Ser Phe Leu 
65                  70                  75                  80  


Glu Lys Val Arg Glu Ile Ser Val Leu Phe Phe Arg Ser Ser Met Lys 
                85                  90                  95      


Asp Lys Lys Lys Cys Leu Arg Ala Glu Asp Asp Phe Glu Gly Tyr Gly 
            100                 105                 110         


Asn Asp Val Ile Leu Leu Asp Gln Gln Thr Leu Asp Trp Val Asp Arg 
        115                 120                 125             


Leu Ile Ser Leu Glu Val Leu Asp Glu Tyr Thr Ser Lys Ile Glu Leu 
    130                 135                 140                 


Ile Asn Lys Val Val Leu Lys Ala Leu Ala Arg Ser Leu Asn Leu Glu 
145                 150                 155                 160 


Asp Asn Cys Phe Leu Asn Gln Tyr Gly Thr Thr Ala Lys Met His Ala 
                165                 170                 175     


Arg Phe Asn Tyr Tyr Pro Pro Cys Gln Trp Ala Asn Asn Pro His Ala 
            180                 185                 190         


Asp Gly Thr Ala Ile Thr Val Leu Leu Gln Asp Lys Glu Ile Glu Gly 
        195                 200                 205             


Leu Gln Leu Leu Lys Asp Gly Gln Trp Val Gly Val Pro Ile Val Arg 
    210                 215                 220                 


Asp Pro Leu Thr Ile Asn Val Gly Asp Gln Ile Glu Cys 
225                 230                 235         


<210>  474
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  474

Met Ser Asn Ser Leu Asp Phe Arg Ala Pro Pro Pro Ser Pro Val Gly 
1               5                   10                  15      


Pro Gly Arg Arg Ser Thr Val Ala Asn Asp Asp Ile Leu Thr Asp Phe 
            20                  25                  30          


Leu His Gln Thr Leu Ile Val Pro Asp Leu Val Leu Pro Asp Arg Val 
        35                  40                  45              


Phe Pro Arg Gln Asn Pro Asn Ile Gln Ser Leu Pro Lys Leu Asp Phe 
    50                  55                  60                  


Lys Lys Leu Ser Phe Ser Asp Asp Phe Lys Leu Glu Asp Val Ile Glu 
65                  70                  75                  80  


Val Ile Ala Gln Thr Gly Cys Phe Glu Leu Val Asn His Gly Ile Ser 
                85                  90                  95      


Arg Lys Leu Phe Arg Asp Val Lys Glu Cys Gly Lys Arg Val Phe Gly 
            100                 105                 110         


Leu Glu Asp Glu Lys Lys Arg Val Ile Leu Arg Ser Asn Glu Arg Leu 
        115                 120                 125             


Tyr Gly Phe Val Glu Val Asn Gly Asp Asp Lys Asp Leu Ile Lys Ser 
    130                 135                 140                 


Met Ser Asn Ser Leu Asp Phe Arg Ala Pro Pro Pro Ser Pro Val Gly 
145                 150                 155                 160 


Pro Gly Arg Arg Ser Thr Val Ala Asn Asp Asp Ile Leu Thr Asp Phe 
                165                 170                 175     


Leu His Gln Thr Leu Ile Val Pro Asp Leu Val Leu Pro Asp Arg Val 
            180                 185                 190         


Phe Pro Arg Gln Asn Pro Asn Ile Gln Ser Leu Pro Lys Leu Asp Phe 
        195                 200                 205             


Lys Lys Leu Ser Phe Ser Asp Asp Phe Lys Leu Glu Asp Val Ile Glu 
    210                 215                 220                 


Val Ile Ala Gln Thr Gly Cys Phe Glu Leu Val Asn His Gly Ile Ser 
225                 230                 235                 240 


Arg Lys Leu Phe Arg Asp Val Lys Glu Cys Gly Lys Arg Val Phe Gly 
                245                 250                 255     


Leu Glu Asp Glu Lys Lys Arg Val Ile Leu Arg Ser Asn Glu Arg Leu 
            260                 265                 270         


Tyr Gly Phe Val Glu Val Asn Gly Asp Asp Lys Asp Val Ser Glu Glu 
        275                 280                 285             


Phe Val Trp Cys Arg Asp Glu Ser Leu Arg Ser Glu Met Glu Gly Val 
    290                 295                 300                 


Trp Met Ser Tyr Thr Asp Phe Ser Glu Lys Met Glu Asn Leu Met Ser 
305                 310                 315                 320 


Lys Ile Glu Asn Ile Ser Glu Ser Leu Leu Lys Leu Phe Leu Asp Pro 
                325                 330                 335     


Tyr Thr Pro Lys Ser Arg Val Asp Glu Glu Ser Thr Arg Asp Lys Glu 
            340                 345                 350         


Thr Met Gly Ser Met Cys Tyr Leu Tyr Lys His Ser Lys Asn Thr Asp 
        355                 360                 365             


Asn Leu Ser Asn Asp Asp Glu Tyr Met Asp Ser Leu Ser Tyr Asp Val 
    370                 375                 380                 


Ile Arg Met Leu Ile Arg Gly Ser Glu His Lys His Thr Leu Cys Phe 
385                 390                 395                 400 


His Val Cys Asp Gly Ser Ser Glu Phe His Val Tyr Ser Lys Lys Gly 
                405                 410                 415     


Trp Val Ser Phe Ser Pro Asp Lys Asn Ala Leu Val Val Thr Ile Gly 
            420                 425                 430         


Asp Gln Leu Gln Thr Trp Ser Glu Gly Lys Tyr Lys His Val Ile Gly 
        435                 440                 445             


Arg Pro Ile Phe Lys Gly Glu Leu Glu Asp Cys Ile Ser Met Ala Phe 
    450                 455                 460                 


Leu Tyr Ser Pro Pro Ile Ser Lys Gly Gln Glu Asp Lys Thr Ile Ser 
465                 470                 475                 480 


Leu Val Asn Gln Ile Leu Leu Ala Leu Phe Leu Thr Phe Ile Tyr Asn 
                485                 490                 495     


Leu Phe Ser Tyr Ile Ser Thr 
            500             


<210>  475
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  475

Met Gly Ser Leu Asp Glu Gly Trp Pro Glu Pro Val Val Cys Val Gln 
1               5                   10                  15      


Ser Leu Ser Asp Ser Gly Glu Leu Ser Ile Pro Asp Arg Tyr Ile Lys 
            20                  25                  30          


Pro Gln Pro Glu Arg Pro Ser Leu Ser Val Leu Asn Asp Met Asp Ile 
        35                  40                  45              


Pro Ile Ile Asp Phe Asn Gly Leu Val Thr Ser Pro Glu Ala Thr Met 
    50                  55                  60                  


Lys Gln Ile Ser Lys Ala Cys Arg Glu Trp Gly Phe Phe Gln Leu Val 
65                  70                  75                  80  


Asn His Gly Val Arg Thr Asp Leu Val Asp Gly Val Arg Glu Thr Trp 
                85                  90                  95      


Arg Glu Phe Phe His Glu Pro Met Glu Val Lys Gln Lys Tyr Ala Asn 
            100                 105                 110         


Ser Pro Lys Thr Tyr Glu Gly Phe Gly Ser Arg Leu Gly Thr Glu Lys 
        115                 120                 125             


Gly Ala Ile Leu Asp Trp Ser Asp Tyr Tyr Tyr Leu His Tyr Arg Pro 
    130                 135                 140                 


Pro Cys Asn Thr Lys Trp Pro Asp Gln Pro Pro Ser Leu Ser Leu Leu 
145                 150                 155                 160 


Arg Ala Ile Ser Thr Gln Thr Cys Pro Leu Thr Arg Leu Glu Leu Gly 
                165                 170                 175     


Val Asp Leu Ser Phe Leu Val Ser Ser Gly Ala Lys Trp Pro Ser Tyr 
            180                 185                 190         


Pro Val Ser Lys Ser Val Asp Ser Asn Val Arg Lys Met Asn His Met 
        195                 200                 205             


Val Leu Ser Asn Ala Ile Tyr Lys Ser Val Glu His Arg Val Val Val 
    210                 215                 220                 


Asn Pro Asn Lys Glu Arg Val Ser Leu Ala Tyr Phe Tyr Asn Pro Lys 
225                 230                 235                 240 


Ser Asp Met Leu Ile Gln Pro Ile Ser Glu Leu Val Thr Ser Lys Lys 
                245                 250                 255     


Pro Ala Leu Tyr Leu Pro Met Thr Phe Glu Glu Tyr Arg Arg Phe Ile 
            260                 265                 270         


Arg Thr Lys Gly Pro Gln Gly Lys Phe Gln Val Glu Ser Leu Lys Ser 
        275                 280                 285             


Pro Arg 
    290 


<210>  476
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (208)..(208)
<223>  Xaa can be any naturally occurring amino acid

<400>  476

Met Ile Ile Glu Pro Met Glu Thr Val Ala Ala Glu Ile Lys His Ala 
1               5                   10                  15      


Ser Gln Phe Thr Thr Lys Glu Thr Thr Glu Met Lys Asp Ile Ser Glu 
            20                  25                  30          


Phe Met Leu Ala Glu Pro Lys Glu Thr Pro Glu Met Lys Asp Phe Ser 
        35                  40                  45              


Glu Phe Thr Leu Ala Glu Val Thr Lys Val Glu Pro Glu Trp Leu Val 
    50                  55                  60                  


Glu Ile Ala Thr His Tyr Tyr Glu Arg Lys Asn Leu Lys Tyr Phe Arg 
65                  70                  75                  80  


Ala Pro Pro Pro Ser Pro Val Gly Pro Gly Arg Arg Ser Thr Val Ala 
                85                  90                  95      


Asn Asp Asp Ile Leu Thr Asp Phe Leu His Gln Thr Leu Ile Val Pro 
            100                 105                 110         


Asp Leu Val Leu Pro Asp Arg Val Phe Pro Arg Gln Asn Pro Asn Ile 
        115                 120                 125             


Gln Ser Leu Pro Lys Leu Asp Phe Glu Lys Leu Gly Phe Ser Asp Asp 
    130                 135                 140                 


Phe Lys Leu Glu Asp Val Ile Glu Val Ile Ala Gln Thr Gly Cys Phe 
145                 150                 155                 160 


Glu Leu Val Asn His Gly Ile Ser Arg Lys Leu Leu Arg Asp Val Lys 
                165                 170                 175     


Glu Cys Gly Lys Gly Val Phe Gly Leu Glu Asp Glu Lys Lys Arg Val 
            180                 185                 190         


Val Leu Arg Ser Asn Glu Arg Leu Tyr Gly Phe Val Glu Met Ser Xaa 
        195                 200                 205             


Glu Val Ile Ala Gln Thr Gly Cys Phe Glu Leu Val Asn His Gly Ile 
    210                 215                 220                 


Ser Arg Lys Leu Leu Arg Asp Val Lys Glu Cys Gly Lys Gly Val Phe 
225                 230                 235                 240 


Gly Leu Glu Asp Glu Lys Lys Arg Val Val Leu Arg Ser Asn Glu Arg 
                245                 250                 255     


Leu Tyr Gly Phe Val Glu Val Asn Gly Asp Asp Lys Asp Val Ser Glu 
            260                 265                 270         


Glu Phe Val Trp Cys Arg Asp Glu Ser Leu Arg Ser Glu Met Glu Gly 
        275                 280                 285             


Val Trp Ser Asn Tyr Ser Asp Phe Ser Glu Lys Met Glu Asn Leu Met 
    290                 295                 300                 


Ser Lys Ile Glu Asn Ile Ser Glu Ser Leu Leu Lys Leu Phe Leu Asp 
305                 310                 315                 320 


Pro Tyr Thr Pro Lys Ser Arg Val Asp Glu Glu Ser Thr Arg Asp Lys 
                325                 330                 335     


Glu Thr Met Gly Ser Met Cys Tyr Leu Tyr Lys His Ser Lys Asn Thr 
            340                 345                 350         


Asp Asn Leu Ser Asn Asp Asp Glu Tyr Met Asp Ser Leu Ser Tyr Asp 
        355                 360                 365             


Val Ile Arg Met Leu Ile Arg Gly Ser Glu His Lys His Thr Leu Cys 
    370                 375                 380                 


Phe His Val Cys Asp Gly Ser Ser Glu Phe His Val Tyr Ser Lys Lys 
385                 390                 395                 400 


Gly Trp Val Ser Phe Ser Pro Asp Lys Asn Ala Leu Val Val Thr Ile 
                405                 410                 415     


Gly Asp Gln Leu Gln Thr Trp Ser Glu Gly Lys Tyr Lys His Val Ile 
            420                 425                 430         


Gly Arg Pro Ile Phe Lys Gly Glu Leu Glu Asp Cys Ile Ser Met Ala 
        435                 440                 445             


Phe Leu Asn Ser Pro Pro Thr Ser Lys Gly Gln Glu Asp Asn Thr Ile 
    450                 455                 460                 


Ser Leu Gly Asn Gln Ile Leu Leu Ala Leu Phe Leu Thr Phe Ile Tyr 
465                 470                 475                 480 


Asn Leu Phe Ser Tyr Phe Ser Thr 
                485             


<210>  477
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (209)..(209)
<223>  Xaa can be any naturally occurring amino acid

<400>  477

Met Ile Ile Glu Pro Met Glu Thr Val Ala Ala Glu Ile Lys His Ala 
1               5                   10                  15      


Ser Gln Phe Thr Thr Asn Glu Thr Thr Glu Met Asn Leu Asp Val Pro 
            20                  25                  30          


Glu Phe Thr Leu Pro Glu Pro Lys Glu Thr Pro Glu Met Lys Asp Phe 
        35                  40                  45              


Ser Glu Phe Thr Leu Ala Glu Val Thr Lys Val Glu Pro Glu Trp Leu 
    50                  55                  60                  


Val Glu Ile Ala Thr His Tyr Tyr Glu Arg Lys Asn Leu Lys Tyr Phe 
65                  70                  75                  80  


Arg Ala Pro Pro Pro Ser Pro Val Gly Pro Gly Arg Arg Ser Thr Val 
                85                  90                  95      


Ala Asn Asp Asp Ile Leu Thr Asp Phe Leu His Gln Thr Leu Ile Val 
            100                 105                 110         


Pro Asp Leu Val Leu Pro Asp Arg Val Phe Pro Arg Gln Asn Pro Asn 
        115                 120                 125             


Ile Gln Ser Leu Pro Lys Leu Asp Phe Glu Lys Leu Gly Phe Ser Asp 
    130                 135                 140                 


Asp Phe Lys Leu Glu Asp Val Ile Glu Val Ile Ala Gln Thr Gly Cys 
145                 150                 155                 160 


Phe Glu Leu Val Asn His Gly Ile Ser Arg Lys Leu Leu Arg Asp Val 
                165                 170                 175     


Lys Glu Cys Gly Lys Gly Val Phe Gly Leu Glu Asp Glu Lys Lys Arg 
            180                 185                 190         


Val Val Leu Arg Ser Asn Glu Arg Leu Tyr Gly Phe Val Glu Met Ser 
        195                 200                 205             


Xaa Glu Val Ile Ala Gln Thr Gly Cys Phe Glu Leu Val Asn His Gly 
    210                 215                 220                 


Ile Ser Arg Lys Leu Leu Arg Asp Val Lys Glu Cys Gly Lys Gly Val 
225                 230                 235                 240 


Phe Gly Leu Glu Asp Glu Lys Lys Arg Val Val Leu Arg Ser Asn Glu 
                245                 250                 255     


Arg Leu Tyr Gly Phe Val Glu Val Asn Gly Asp Asp Lys Asp Val Ser 
            260                 265                 270         


Glu Glu Phe Val Trp Cys Arg Asp Glu Ser Leu Arg Ser Glu Met Glu 
        275                 280                 285             


Gly Val Trp Ser Asn Tyr Ser Asp Phe Ser Glu Lys Met Glu Asn Leu 
    290                 295                 300                 


Met Ser Lys Ile Glu Asn Ile Ser Glu Ser Leu Leu Lys Leu Phe Leu 
305                 310                 315                 320 


Asp Pro Tyr Thr Pro Lys Ser Arg Val Asp Glu Glu Ser Thr Arg Asp 
                325                 330                 335     


Lys Glu Thr Met Gly Ser Met Cys Tyr Leu Tyr Lys His Ser Lys Asn 
            340                 345                 350         


Thr Asp Asn Leu Ser Asn Asp Asp Glu Tyr Met Asp Ser Leu Ser Tyr 
        355                 360                 365             


Asp Val Ile Arg Met Leu Ile Arg Gly Ser Glu His Lys His Thr Leu 
    370                 375                 380                 


Cys Phe His Val Cys Asp Gly Ser Ser Glu Phe His Val Tyr Ser Lys 
385                 390                 395                 400 


Lys Gly Trp Val Ser Phe Ser Pro Asp Lys Asn Ala Leu Val Val Thr 
                405                 410                 415     


Ile Gly Asp Gln Leu Gln Thr Trp Ser Glu Gly Lys Tyr Lys His Val 
            420                 425                 430         


Ile Gly Arg Pro Ile Phe Lys Gly Glu Leu Glu Asp Cys Ile Ser Met 
        435                 440                 445             


Ala Phe Leu Asn Ser Pro Pro Thr Ser Lys Gly Gln Glu Asp Asn Thr 
    450                 455                 460                 


Ile Ser Leu Gly Asn Gln Ile Leu Leu Ala Leu Phe Leu Thr Phe Ile 
465                 470                 475                 480 


Tyr Asn Leu Phe Ser Tyr Phe Ser Thr 
                485                 


<210>  478
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  478

Met Ala Ser Leu Thr Ala Glu Gln Asn Tyr Asp His Leu Lys Glu Val 
1               5                   10                  15      


Thr Gln Phe Asp Glu Ser Lys Leu Gly Ala Lys Gly Leu Leu Asp Ser 
            20                  25                  30          


Gly Ile Thr Thr Ile Pro Arg Ile Phe His Gln Pro Pro Glu Asn Leu 
        35                  40                  45              


Pro Gly Pro Gln Pro Lys Thr Arg Pro Gln Leu Thr Val Pro Val Ile 
    50                  55                  60                  


Asp Leu Ser Gln Asp Arg Ser Lys Val Val Glu Glu Ile Arg Arg Cys 
65                  70                  75                  80  


Ala Ser Thr Leu Gly Phe Phe Gln Ile Val Asn His Ser Ile Pro Val 
                85                  90                  95      


Thr Leu Ile Gly Ser Val Leu Asn Asp Thr Lys Lys Phe Tyr Glu Gln 
            100                 105                 110         


Ser Thr Glu Tyr Lys Met Gln Phe Tyr Gly Arg Glu Thr Glu Asn Gly 
        115                 120                 125             


Ala Thr Tyr Ala Thr Asn Leu Asp Leu Tyr Gln Ser Lys Ala Ala Ser 
    130                 135                 140                 


Trp Arg Asp Thr Ile Glu Val Trp Met Ser Pro Lys Glu Pro Lys Trp 
145                 150                 155                 160 


Glu Ala Val Pro Glu Met Cys Trp Thr Ala Leu Lys Asp Trp Asp Lys 
                165                 170                 175     


Ala Val Val Gly Leu Ala Glu Glu Leu Met Ala Ile Leu Cys Glu Gly 
            180                 185                 190         


Leu Gly Asn Glu Ile Gly Gly Leu Leu Gln Ala Lys Cys Gly Glu Asp 
        195                 200                 205             


Trp Val Val Val Glu Ala Val Pro Gly Ala Val Val Ile Asn Ile Gly 
    210                 215                 220                 


Asp Met Leu Gln Met Met Ser Asn Asp Ala Tyr Arg Ser Val Glu His 
225                 230                 235                 240 


Arg Val Leu Ala Asn Asn Ala Glu Val Ala Pro Leu Ser Phe Ala Val 
                245                 250                 255     


Phe Phe Glu Pro Ser Asn Arg Glu Gly Leu Tyr Gly Pro Phe Pro Glu 
            260                 265                 270         


Leu Ile Ser Ala Glu Lys Pro Val Ile Tyr His Lys Phe Met Phe Glu 
        275                 280                 285             


Asp Phe Cys Arg Arg Phe Leu Ser Lys Glu Leu Asp Gly Lys Ser Lys 
    290                 295                 300                 


Leu Asp Tyr Tyr Arg Ile Asp Asn Thr Asn Lys Ala 
305                 310                 315     


<210>  479
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  479

Met Lys Thr His Lys Ile Ile Cys Gln Ile Cys Ser Ser Arg Glu Thr 
1               5                   10                  15      


Gly Phe Glu Ser Leu Arg Pro Thr Val Ala Leu Leu Tyr Glu Asp Gly 
            20                  25                  30          


Ser Pro Val Glu Ala Lys Gly Val Gly Arg Arg Val Leu Val Leu Ile 
        35                  40                  45              


Leu Lys Val Phe Leu Leu Val Met Met Leu Leu Val Tyr Gln Gln Gln 
    50                  55                  60                  


Val Cys Arg Glu Lys Leu Lys His Pro Arg Thr Trp Glu Asn Val Asn 
65                  70                  75                  80  


His Val Lys Gly Ala Phe Ile Val Asn Leu Gly Asp Met Met Glu Arg 
                85                  90                  95      


Trp Thr Asn Cys Leu Phe Arg Ser Thr Leu His Arg Val Met Pro Thr 
            100                 105                 110         


Gly Lys Glu Arg Tyr Ser Ala His Val Ser Arg Met Gln Ser Ile Ala 
        115                 120                 125             


Arg Arg Leu Ala Arg Asp Ser Ser Ala Tyr Gly Pro Ala Ile Arg Ser 
    130                 135                 140                 


Ile Tyr Pro Ile Ser Asp Gln Tyr Tyr Gly Gly Tyr Gly Tyr Asp Arg 
145                 150                 155                 160 


Arg Tyr Ala Ser Thr Val Pro Ala Lys Gly Val Gly His Leu Arg Leu 
                165                 170                 175     


Gly Met Leu Val Leu Ile Asp Val Glu Val Ser Asp Leu Ser Lys Cys 
            180                 185                 190         


Glu Ile Gly Ile Val Ala Thr Val Phe Gly Ala Thr Gly Phe Leu Gly 
        195                 200                 205             


Arg Tyr Leu Val Gln Glu Leu Ala Lys Met Gly Ser Gln Val Leu Val 
    210                 215                 220                 


Pro Phe Arg Gly Ser Glu Asp Ser Pro Arg His Leu Lys Leu Met Gly 
225                 230                 235                 240 


Asp Leu Gly Gln Ile Val Pro Met Lys Tyr Asn Pro Arg Asp Glu Asn 
                245                 250                 255     


Ser Ile Lys Ala Val Met Ala Lys Ala Asn Val Val Ile Asn Leu Ile 
            260                 265                 270         


Gly Arg Glu Tyr Gly Thr Arg Asn Tyr Ser Leu Glu Glu Val Asn His 
        275                 280                 285             


His Met Ala Ala Gln Leu Ala Lys Ile Ser Lys Glu His Gly Gly Ile 
    290                 295                 300                 


Met Arg Phe Ile Gln Leu Ser Cys Leu Gly Ala Ser Lys Ser Ser Pro 
305                 310                 315                 320 


Ser Arg Leu Leu Gln Ala Lys Ala Ala Ala Glu Glu Ser Ile Leu Asn 
                325                 330                 335     


Glu Leu Pro Glu Ala Thr Ile Leu Arg Pro Ala Val Met Leu Gly Thr 
            340                 345                 350         


Glu Asp Arg Ile Leu Asn Pro Trp Ala Gln Phe Ala Arg Lys Tyr Asn 
        355                 360                 365             


Phe Leu Pro Leu Val Ser Gly Gly Ser Thr Lys Ile Gln Pro Val Tyr 
    370                 375                 380                 


Val Ala Asp Val Ala Ser Ala Val Val Ala Ala Leu Lys Asp Asp Gly 
385                 390                 395                 400 


Ser Ser Met Gly Lys Leu Tyr Glu Leu Gly Gly Pro Asp Ile His Thr 
                405                 410                 415     


Gln Arg Glu Leu Ala Glu Ile Met Tyr Glu Val Ile Arg Glu Trp Pro 
            420                 425                 430         


His Tyr Val Asn Val Pro Leu Pro Ile Ala Lys Ala Ile Ser Ser Pro 
        435                 440                 445             


Arg Glu Ile Phe Leu Asn Lys Val Pro Phe Pro Leu Pro Ser Pro Ser 
    450                 455                 460                 


Ile Phe Asn Leu Asp Met Ile Thr Ala Tyr Ser Ser Asp Lys Leu Val 
465                 470                 475                 480 


Ser Glu Asp Asp Gly Lys Ile Gly Asn Leu Gly Gly Leu Gly His Gly 
                485                 490                 495     


Ser Asn Arg Ser Phe Lys Val Ile Gln Glu Pro Asn Leu Arg Lys Arg 
            500                 505                 510         


His Leu Gly Asp Leu Gln Gly Leu Val Tyr Val Asp Ala Pro Thr Leu 
        515                 520                 525             


Lys Thr Lys Ala Tyr Glu Ala Leu Gln Ser His Gly Met Asp Val Glu 
    530                 535                 540                 


Ile Pro Gly Gly Gly Glu Ser Leu Asn Gln Leu Ser Arg Arg Cys Thr 
545                 550                 555                 560 


Ala Ser Leu Gln Thr Ile Ala Arg Glu Arg Val Val Val Val Thr His 
                565                 570                 575     


Gly Gly Val Ile Arg Ala Leu His Glu Arg Ala Ser Thr Gly Lys Arg 
            580                 585                 590         


His Arg Val Gly Arg Ile Leu Asn Val Ser Val Asn Val Leu His Leu 
        595                 600                 605             


Thr Asp Thr Asp Lys Trp Val Ile Lys Ser Trp Gly Asp Val Ser His 
    610                 615                 620                 


Leu Asn Gly Ala Gly Tyr Leu Asp Ser Gly Phe Gly Cys Asp Lys Thr 
625                 630                 635                 640 


Ser Gly 
        


<210>  480
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  480

Met Ala Arg Arg Asp Ser Leu Pro Val Lys Thr Ala Gln Gln Met Ala 
1               5                   10                  15      


Met Asp Gly Asp Gln Pro Pro Ser Lys Tyr Ile Tyr Ser Asn Asn Thr 
            20                  25                  30          


Ser Tyr Ala Lys Phe Gly Pro Leu Glu Thr Ser Pro Pro Phe Ala Pro 
        35                  40                  45              


Val Pro Val Ile Asp Ile Gly Cys Leu Leu Ser Ser Cys Lys Gln Asp 
    50                  55                  60                  


Glu Gln Glu Asn Glu Leu Ala Lys Leu Arg Ser Ala Leu Thr Thr Trp 
65                  70                  75                  80  


Gly Cys Phe Gln Ala Val Asn His Arg Leu Ser Asp Ser Tyr Leu Asp 
                85                  90                  95      


Asn Ile Arg Gln Val Ile Lys Gln Phe Phe Glu Leu Ser Met Glu Asp 
            100                 105                 110         


Lys Arg Lys Tyr Phe Arg Glu Thr Gly Ser Val Glu Gly Tyr Gly Asn 
        115                 120                 125             


Asp Met Thr Tyr Ser Glu Thr Gln Val Gln Asp Trp Cys Asp Arg Leu 
    130                 135                 140                 


Phe Leu Arg Ile Leu Pro Glu Asp Gln Arg Lys Leu Arg Phe Trp Pro 
145                 150                 155                 160 


Glu Asn Pro Ser Asn Phe Arg Glu Thr Ile Asp Asp Tyr Thr Lys Lys 
                165                 170                 175     


Ile Met Ser Ile Ser Val Val Ile Phe Lys Ala Met Ala Lys Ser Leu 
            180                 185                 190         


Glu Leu Glu Glu Asn Cys Phe Ser Lys His Phe Thr Glu Glu Ser Asp 
        195                 200                 205             


Val Leu Gln Gly Arg Phe Ile Leu Tyr Pro Pro Cys Pro Thr Pro Asp 
    210                 215                 220                 


Lys Val Phe Gly Leu Lys Ala His Ser Asp Arg Ser Gly Ile Thr Leu 
225                 230                 235                 240 


Leu Leu Gln Asp Pro Gly Val Glu Gly Leu Gln Val Leu Asn Asp Ser 
                245                 250                 255     


Lys Trp Tyr Met Val Pro Val Ile Pro Glu Ala Leu Phe Ile Asn Leu 
            260                 265                 270         


Gly Asp Gln Met Gln Ile Leu Ser Asn Gly Ile Phe Lys Ser Pro Val 
        275                 280                 285             


His Arg Val Val Thr Asn Ser Asp Lys Gly Arg Ile Ser Val Ala Met 
    290                 295                 300                 


Phe Thr Glu Pro Glu Pro Asn Lys Glu Ile Gly Pro Val Asp Ala Leu 
305                 310                 315                 320 


Val Asp Glu Lys Arg Pro Arg Val Tyr Lys Thr Val Lys Asp Tyr Ala 
                325                 330                 335     


Val Phe Asn His Glu Cys Phe Gln Lys Gly Val Val Ala Leu Asp Ala 
            340                 345                 350         


Val Lys Leu 
        355 


<210>  481
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  481

Met Met Lys Gln Thr Gln Asp Ile Ala Glu Asn Cys Asp Gln Pro Pro 
1               5                   10                  15      


Glu Arg Tyr Ile His Lys Gln Asp Glu Glu Tyr Gly Ala Asn Asn Val 
            20                  25                  30          


Gly Asn Ala Ala His Val Ile Thr Ala Ala Ala Ile Pro Val Ile Asp 
        35                  40                  45              


Phe Ser Leu Leu Asn Ser Ser Pro Ser Glu Leu Val Lys Leu Lys Ser 
    50                  55                  60                  


Ala Ala Thr Thr Leu Gly Cys Phe Gln Ala Ile Asn His Gly Ile Glu 
65                  70                  75                  80  


Ser Ser Phe Leu Glu Glu Val Arg Glu Ile Ser Lys Leu Phe Phe Lys 
                85                  90                  95      


Leu Pro Ala Asp Glu Lys Lys Lys Cys Leu Lys Glu Glu Asn Asp Val 
            100                 105                 110         


Gln Gly Tyr Gly Asn Glu Thr Val Phe Ser Asp Asn Gln Thr Leu Asp 
        115                 120                 125             


Trp Thr Asp Arg Leu Tyr Leu Thr Val Leu Pro Gln His Gln Arg Arg 
    130                 135                 140                 


Leu Gln Phe Trp Pro Gln Asn Pro Thr His Phe Arg Lys Val Leu Asn 
145                 150                 155                 160 


Glu Tyr Ser Phe Lys Ile Glu Ser Leu Asn Val Val Val Leu Lys Ala 
                165                 170                 175     


Leu Ala Arg Ser Leu Asn Leu Glu Glu Asp Cys Phe Met Asn Gln Tyr 
            180                 185                 190         


Gly Lys Thr Ser Lys Ile Asn Ala Arg Phe Asn Tyr Tyr Pro Pro Cys 
        195                 200                 205             


Pro Leu Pro Glu Lys Val Leu Gly Leu Lys Pro His Gly Asp Gly Ser 
    210                 215                 220                 


Ala Ile Thr Phe Leu Leu Gln Asp Lys Glu Val Glu Gly Leu Gln Leu 
225                 230                 235                 240 


Leu Lys Asp Asp Glu Trp Val Gly Val Pro Val Val Ser Asn Ala Leu 
                245                 250                 255     


Thr Ile Asn Ile Gly Asp Gln Met Glu Ile Met Ser Asn Gly Ile Phe 
            260                 265                 270         


Lys Ser Pro Leu His Arg Val Phe Val Asn Ser Lys Asn Glu Arg Met 
        275                 280                 285             


Thr Leu Ala Met Phe Cys Met Pro Gln Thr Glu Lys Asn Ile Gly Pro 
    290                 295                 300                 


Val Asp Gly Leu Ile Thr Asp Glu Thr Pro Arg Leu Tyr Lys Asp Ile 
305                 310                 315                 320 


Thr Phe Thr Leu Asp Phe Met His Lys Asn Tyr Gln Gln Gly Arg Arg 
                325                 330                 335     


Ala Ile Asn Ala Cys Lys Ile 
            340             


<210>  482
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  482

Met Val Leu Ser Glu Asn Gln Thr Leu Asp Trp Thr Asp Arg Leu Tyr 
1               5                   10                  15      


Leu Thr Ala Leu Pro Gln Asp Gln Gln Arg Leu Gln Phe Trp Pro Gln 
            20                  25                  30          


Asn Pro Thr Asn Phe Arg Glu Ile Leu Asp Glu Tyr Ser Ser Lys Ile 
        35                  40                  45              


Gln Leu Val Asn Glu Val Val Leu Lys Ala Leu Ala Arg Ser Leu Asn 
    50                  55                  60                  


Leu Glu Glu Asp Cys Phe Leu Asn Gln Tyr Gly Thr Thr Ala Lys Met 
65                  70                  75                  80  


Gln Ala Arg Phe Asn Tyr Tyr Pro Pro Cys Pro Trp Pro Glu Lys Val 
                85                  90                  95      


Leu Gly Val Lys Pro His Ala Asp Gly Ser Ala Ile Thr Val Leu Leu 
            100                 105                 110         


Gln Asp Lys Glu Val Glu Gly Leu Gln Leu Leu Lys Asp Asp Gln Trp 
        115                 120                 125             


Val Gly Val Pro Ile Val Pro Asp Ala Leu Thr Ile Asn Val Gly Asp 
    130                 135                 140                 


Gln Ile Glu Ile Met Ser Asn Gly Ile Phe Lys Ser Pro Val His Arg 
145                 150                 155                 160 


Val Phe Val Asn Ser Lys Asn Glu Arg Met Thr Leu Ala Met Phe Cys 
                165                 170                 175     


Met Pro Gln Thr Glu Lys Asp Ile Gly Pro Val Asp Gly Leu Ile Thr 
            180                 185                 190         


Asn Glu Arg Pro Arg Leu Tyr Lys Asn Val Thr Phe Thr Leu Asp Phe 
        195                 200                 205             


Phe Phe Lys Asn Tyr Gln Gln Gly Arg Arg Pro Ile Asp Ala Cys Arg 
    210                 215                 220                 


Ile 
225 


<210>  483
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  483

Met Met Phe Asp Trp Phe Gln Ala Ile Asn His Gly Ile Asp Gly Ser 
1               5                   10                  15      


Phe Leu Glu Lys Val Arg Glu Ile Ser Lys Leu Phe Phe Lys Leu Pro 
            20                  25                  30          


Ala Asp Glu Lys Lys Lys Tyr Leu Arg Glu Glu Asn Asp Val Glu Gly 
        35                  40                  45              


Tyr Gly Asn Asp Met Val Leu Ser Glu Asn Gln Thr Leu Asp Trp Thr 
    50                  55                  60                  


Asp Arg Leu Tyr Leu Thr Ala Leu Pro Gln Asp Gln Gln Arg Leu Gln 
65                  70                  75                  80  


Phe Trp Pro Gln Asn Pro Thr Asn Phe Arg Glu Ile Leu Asp Glu Tyr 
                85                  90                  95      


Ser Ser Lys Ile Gln Leu Val Asn Glu Val Val Leu Lys Ala Leu Ala 
            100                 105                 110         


Arg Ser Leu Asn Leu Glu Glu Asp Cys Phe Leu Asn Gln Tyr Gly Thr 
        115                 120                 125             


Thr Ala Lys Met Gln Ala Arg Phe Asn Tyr Tyr Pro Pro Cys Pro Trp 
    130                 135                 140                 


Pro Glu Lys Val Leu Gly Val Lys Pro His Ala Asp Gly Ser Ala Ile 
145                 150                 155                 160 


Thr Val Leu Leu Gln Asp Lys Glu Val Glu Gly Leu Gln Leu Leu Lys 
                165                 170                 175     


Asp Asp Gln Trp Val Gly Val Pro Ile Val Pro Asp Ala Leu Thr Ile 
            180                 185                 190         


Asn Val Gly Asp Gln Ile Glu Ile Met Ser Asn Gly Ile Phe Lys Ser 
        195                 200                 205             


Pro Val His Arg Val Phe Val Asn Ser Lys Asn Glu Arg Met Thr Leu 
    210                 215                 220                 


Ala Met Phe Cys Met Pro Gln Thr Glu Lys Asp Ile Gly Pro Val Asp 
225                 230                 235                 240 


Gly Leu Ile Thr Asn Glu Arg Pro Arg Leu Tyr Lys Asn Val Thr Phe 
                245                 250                 255     


Thr Leu Asp Phe Phe Phe Lys Asn Tyr Gln Gln Gly Arg Arg Pro Ile 
            260                 265                 270         


Asp Ala Cys Arg Ile 
        275         


<210>  484
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  484

Met Met Phe Asp Trp Phe Gln Ala Ile Asn His Gly Ile Asp Gly Ser 
1               5                   10                  15      


Phe Leu Glu Lys Val Arg Glu Ile Ser Lys Leu Phe Phe Lys Leu Pro 
            20                  25                  30          


Ala Asp Glu Lys Lys Lys Tyr Leu Arg Glu Glu Asn Asp Val Glu Gly 
        35                  40                  45              


Tyr Gly Asn Asp Met Val Leu Ser Glu Asn Gln Thr Leu Asp Trp Thr 
    50                  55                  60                  


Asp Arg Leu Tyr Leu Thr Ala Leu Pro Gln Asp Gln Gln Arg Leu Gln 
65                  70                  75                  80  


Phe Trp Pro Gln Asn Pro Thr Asn Phe Arg Glu Ile Leu Asp Glu Tyr 
                85                  90                  95      


Ser Ser Lys Ile Gln Leu Val Asn Glu Val Val Leu Lys Ala Leu Ala 
            100                 105                 110         


Arg Ser Leu Asn Leu Glu Glu Asp Cys Phe Leu Asn Gln Tyr Gly Thr 
        115                 120                 125             


Thr Ala Lys Met Gln Ala Arg Phe Asn Tyr Tyr Pro Pro Cys Pro Trp 
    130                 135                 140                 


Pro Glu Lys Val Leu Gly Val Lys Pro His Ala Asp Gly Ser Ala Ile 
145                 150                 155                 160 


Thr Val Leu Leu Gln Asp Lys Glu Val Glu Gly Leu Gln Leu Leu Lys 
                165                 170                 175     


Asp Asp Gln Trp Val Gly Val Pro Ile Val Pro Asp Ala Leu Thr Ile 
            180                 185                 190         


Asn Val Gly Asp Gln Ile Glu Ile Met Ser Asn Gly Ile Phe Lys Ser 
        195                 200                 205             


Pro Val His Arg Val Phe Val Asn Ser Lys Asn Glu Arg Met Thr Leu 
    210                 215                 220                 


Ala Met Phe Cys Met Pro Gln Thr Glu Lys Asp Ile Gly Pro Val Asp 
225                 230                 235                 240 


Gly Leu Ile Thr Asn Glu Arg Pro Arg Leu Tyr Lys Asn Val Thr Phe 
                245                 250                 255     


Thr Leu Asp Phe Phe Phe Lys Asn Tyr Gln Gln Gly Gly Cys Lys Ser 
            260                 265                 270         


Phe Ala Val Ser Ser Ser Ser Ser Val Pro Leu Thr Asn Leu Lys Ile 
        275                 280                 285             


Trp Lys Ala 
    290     


<210>  485
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  485

Met Met Gln Ile Ala Lys Asp Phe Phe Ser Phe Pro Glu Glu Glu Arg 
1               5                   10                  15      


Leu Lys Ser Tyr Ser Asp Asp Pro Asn Lys Ala Thr Arg Leu Ser Thr 
            20                  25                  30          


Ser Phe Asn Ile Gln Thr Glu Lys Val Ala Asn Trp Arg Asp Phe Leu 
        35                  40                  45              


Arg Leu Arg Cys Tyr Pro Leu Glu Asp Tyr Val His Glu Trp Pro Thr 
    50                  55                  60                  


Asn Pro Ser Met Phe Arg Ala His Val Lys Glu Tyr Cys Thr Ile Val 
65                  70                  75                  80  


Arg Gly Leu Ala Leu Glu Leu Val Glu Ala Ile Ser Glu Ser Leu Gly 
                85                  90                  95      


Leu Glu Arg Asp Tyr Ile Gly Lys Gln Leu Gly Lys His Glu Gln His 
            100                 105                 110         


Met Ala Leu Asn Tyr Tyr Pro Pro Cys Pro Gln Pro Asp Leu Thr Tyr 
        115                 120                 125             


Ala Gln Val Leu Ser Asn Asp Lys Tyr Lys Ser Ile Leu His Arg Ala 
    130                 135                 140                 


Val Val Asn Cys Asp Lys Glu Arg Ile Ser Ile Pro Thr Phe Tyr Cys 
145                 150                 155                 160 


Pro Ser Arg Asp Ala Met Ile Ser Pro Ala Pro Gln Leu Val Thr Lys 
                165                 170                 175     


Asp Gln Pro Ala Val Tyr Arg Pro Phe Arg Tyr Gly Glu Tyr Tyr Asp 
            180                 185                 190         


Lys Phe Leu Asn Arg Gly Leu Ala Thr Glu Asn Cys Leu Asp Met Phe 
        195                 200                 205             


Met Ala Thr Lys Ser Thr Arg Ser Ala 
    210                 215         


<210>  486
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  486

Met Thr Ser Pro Thr Thr Glu Ala Asn Thr Tyr Asp Arg Glu Thr Glu 
1               5                   10                  15      


Leu Lys Glu Phe Asp Ser Ser Lys Leu Gly Cys Lys Gly Leu Leu Asp 
            20                  25                  30          


Thr Gly Ile Lys Thr Ile Pro Arg Phe Phe His Gln Pro Pro Glu Asn 
        35                  40                  45              


Leu Pro Cys Lys Gln Thr Asn Leu Lys Lys Asn Met Gln Thr Val Pro 
    50                  55                  60                  


Val Ile Asp Met Ser Gln Asp Arg Ser Glu Val Val Glu Gln Val Arg 
65                  70                  75                  80  


Lys Leu Ser Ser Thr Leu Gly Phe Phe Gln Val Val Asn His Gly Val 
                85                  90                  95      


Asp Val Gln Met Ile Glu Ser Val Ile Asn Gly Ile Lys Asp Phe Phe 
            100                 105                 110         


Glu Met Asp Asn Glu Tyr Lys Met Arg Phe Tyr Ser Arg Asp Ala Glu 
        115                 120                 125             


Lys Gly Ala Val Tyr Ser Thr Asn Phe Asp Leu Phe His Ser Lys Ala 
    130                 135                 140                 


Ala Ser Trp Arg Asp Thr Leu Gln Pro Gln Arg Leu Tyr Phe Asn Pro 
145                 150                 155                 160 


Leu Arg Ser Ile Pro Pro Asn His Ile Leu Pro Leu Asp His Ala Val 
                165                 170                 175     


Gly Ala Tyr Arg Arg Gly Gly Asn Gly Val His Arg Arg Val His Met 
            180                 185                 190         


Asn Gly Leu Ser Trp Val Val Phe Asp Leu Asn Trp Val Lys Gln Thr 
        195                 200                 205             


Ser Thr Val Ile Tyr Lys Glu Thr Tyr Arg Glu Thr Gly Gln Thr Gly 
    210                 215                 220                 


Ser Pro Lys Ala Asp Phe Lys Ala Tyr Asn Leu Leu Glu Leu Ser Gly 
225                 230                 235                 240 


Pro Val Trp Val Arg Val His Cys His Lys Asp Leu Ile Arg Val Lys 
                245                 250                 255     


His Ser Gly Leu Phe Arg Glu Val Arg Ile Ala Pro Ile Lys Pro Asp 
            260                 265                 270         


Trp Glu Thr Val Pro Glu Met Cys Arg Glu Ala Leu Lys Asp Trp Asp 
        275                 280                 285             


Lys Ala Val Val Gly Leu Gly Asp Glu Leu Met Ser Ile Leu Cys Glu 
    290                 295                 300                 


Gly Leu Gly Val Lys Ser Asp Lys Leu Lys Glu Leu Ser Cys Leu Glu 
305                 310                 315                 320 


Gly Arg Ala Ser Val Ser His Tyr Tyr Pro Pro Cys Pro Gln Pro Asp 
                325                 330                 335     


Leu Thr Leu Gly Ile Ser Ser His Thr Asp Pro Gly Val Leu Thr Val 
            340                 345                 350         


Leu Val Gln Asn Glu Val Gly Gly Leu Leu Gln Val Lys Cys Gly Glu 
        355                 360                 365             


Asp Trp Ala Ala Val Glu Ala Val Pro Gly Ala Ile Val Ile Asn Ile 
    370                 375                 380                 


Gly Asp Leu Leu Gln Tyr Tyr Pro Ile Ser Gln Met Met Ser Asn Gly 
385                 390                 395                 400 


Glu Tyr Lys Ser Val Glu His Arg Val Leu Ala Asn Pro Glu Glu Val 
                405                 410                 415     


Ala Arg Val Ser Ile Ala Val Phe Leu Thr Pro Gly Ile Arg Glu Ser 
            420                 425                 430         


Leu Tyr Gly Pro Phe Pro Glu Leu Ile Ser Ala Glu Arg Ala Ala Val 
        435                 440                 445             


Tyr Lys Glu Phe Ile Leu Ala Asp Tyr Leu Arg Arg Glu Ala Leu Lys 
    450                 455                 460                 


Asp Trp Asp Lys Ala Val Val Gly Leu Gly Asp Glu Leu Met Ser Ile 
465                 470                 475                 480 


Leu Cys Glu Gly Leu Gly Val Lys Ser Asp Lys Leu Lys Glu Leu Ser 
                485                 490                 495     


Cys Leu Glu Gly Arg Ala Ser Val Ser His Tyr Tyr Pro Pro Cys Pro 
            500                 505                 510         


Gln Pro Asp Leu Thr Leu Gly Ile Ser Ser His Thr Asp Pro Gly Val 
        515                 520                 525             


Leu Thr Val Leu Val Gln Asn Glu Val Gly Gly Leu Leu Gln Val Lys 
    530                 535                 540                 


Cys Gly Glu Asp Trp Ala Ala Val Glu Ala Val Pro Gly Ala Ile Val 
545                 550                 555                 560 


Ile Asn Ile Gly Asp Leu Leu Gln Tyr Tyr Pro Ile Ser Gln Met Met 
                565                 570                 575     


Ser Asn Gly Glu Tyr Lys Ser Val Glu His Arg Val Leu Ala Asn Pro 
            580                 585                 590         


Glu Glu Val Ala Arg Val Ser Ile Ala Val Phe Leu Thr Pro Gly Ile 
        595                 600                 605             


Arg Glu Ser Leu Tyr Gly Pro Phe Pro Glu Leu Ile Ser Ala Glu Arg 
    610                 615                 620                 


Ala Ala Val Tyr Lys Glu Phe Ile Leu Ala Asp Tyr Leu Arg Arg Phe 
625                 630                 635                 640 


Phe Thr Lys Glu Leu Asp Gly Lys Ser Leu Thr Asn Phe Tyr Lys Ile 
                645                 650                 655     


Asp Asp Thr Lys Ser 
            660     


<210>  487
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  487

Met Lys Thr Thr Asn Lys Lys Ser Lys Leu Gly Ser Gly Asp Gly Glu 
1               5                   10                  15      


Phe Arg Ser Asp Ala Glu Ile Thr Asn Phe Asp Asp Arg Arg Tyr Gln 
            20                  25                  30          


Gly Arg Ile Thr Thr Asp Glu Ser Arg Ser Met His Thr Glu Ala Thr 
        35                  40                  45              


Asn Leu Ser Asn Thr Gln Trp Val Leu Gly Phe Gln Ile Ala Val Asn 
    50                  55                  60                  


Gly Pro Ser Pro Ala Ala Asp Gln His Ser Glu Thr Asp Ile Tyr Val 
65                  70                  75                  80  


Cys Ala Gly Glu Tyr Phe Thr Ile Lys Pro Asp Trp Glu Ala Val Pro 
                85                  90                  95      


Glu Met Cys Arg Gln Ser Leu Lys Asp Trp Asp Lys Ala Val Val Ser 
            100                 105                 110         


Leu Gly Asp Asp Phe Met Ser Ile Leu Cys Glu Gly Leu Gly Val Lys 
        115                 120                 125             


Ser Asp Lys Leu Lys Glu Leu Thr Cys Leu Glu Gly Arg Val Ser Val 
    130                 135                 140                 


Ser His Tyr Tyr Pro Gln Cys Pro Gln Pro Glu Leu Thr Leu Gly Ile 
145                 150                 155                 160 


Thr Pro His Thr Asp Pro Gly Val Leu Thr Val Leu Val Gln Asn Lys 
                165                 170                 175     


Val Gly Gly Leu Leu Gln Val Lys Tyr Gly Glu Asp Trp Ala Ala Val 
            180                 185                 190         


Glu Ala Val Pro Gly Ala Ile Leu Phe Gln Ser 
        195                 200             


<210>  488
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  488

Met Ser Thr Tyr Lys Phe Phe Val Ile Thr Ile Ile Phe Ala Pro Val 
1               5                   10                  15      


Thr Pro Cys Ile Ser Gln Leu Glu Gly Gly Ile Val Gln Val Ala Ile 
            20                  25                  30          


Glu Val Glu Asp Arg Ala Gln His Ser Ala Ile Thr Arg Val Asn Thr 
        35                  40                  45              


Ala Asn Asp Val Arg Val Thr Val Ala Ala Pro Ala Ala Arg Gly Lys 
    50                  55                  60                  


Ser Asn Asn Glu Leu Cys Leu Ser Ser Phe Leu His Leu Asp Asn Ile 
65                  70                  75                  80  


Phe Arg Asp Arg Leu Thr Gly Ala Gly Asp Leu Leu Ser Arg Arg Asn 
                85                  90                  95      


Leu Ser Ala Gly Ile Arg His Glu Leu Ser Thr Asn Arg Thr Ser Glu 
            100                 105                 110         


Asp Val Leu Ser Ser Lys Tyr Val Arg Ser Asn Met Thr Arg Ile Glu 
        115                 120                 125             


Ser Tyr Gln Ala Pro Lys Asp Trp Asp Lys Ala Val Val Ser Leu Gly 
    130                 135                 140                 


Asp Glu Leu Met Ser Ile Leu Cys Glu Gly Leu Gly Val Lys Ser Asp 
145                 150                 155                 160 


Lys Leu Lys Cys Leu Glu Gly Arg Val Ser Val Ser His Tyr Tyr Pro 
                165                 170                 175     


Gln Cys Pro Gln Pro Glu Leu Thr Leu Gly Ile Thr Pro His Thr Asp 
            180                 185                 190         


Pro Arg Val Leu Thr Val Leu Val Gln Asn Glu Val Gly Gly Leu Leu 
        195                 200                 205             


Gln Met Cys Pro Arg Lys Gln Glu Val Val Pro Thr Arg Cys Met Lys 
    210                 215                 220                 


Arg Ile Cys Val Tyr Ile Arg Ser Leu Glu Asp Val Phe Ala Ile Leu 
225                 230                 235                 240 


Glu Pro Pro Thr Lys Pro Ser His Asp Gln Asp His Gly Glu Arg Lys 
                245                 250                 255     


Pro Ile Leu Ile Asn Arg Val Tyr Tyr Ile Glu Ser Glu Gln Gln Lys 
            260                 265                 270         


Arg Val Gln Leu Phe Val Ser Glu Asn Gly Cys Arg Arg Ser Lys Val 
        275                 280                 285             


Val Ala Phe Thr Ser Leu Phe Trp Lys Ile Val Ala Leu Ser Met Glu 
    290                 295                 300                 


Glu Ser Gly Ala Ser Asn Lys Val Cys Asn Met Ala Leu Ala Val Asp 
305                 310                 315                 320 


Gly Arg Arg Arg Leu Asn Glu Ile Ala Gly Glu Asp Asn Glu Met Leu 
                325                 330                 335     


Leu Ile Leu His Phe Ser Asn Val Leu Ser Met Pro Ser Gly Ala Ile 
            340                 345                 350         


Arg Ala Gln Val Gly Ile Asn Ile Pro Phe Ser Phe Gln Ala Leu Ser 
        355                 360                 365             


Val Glu Thr Thr Glu Ser Ser Gly Thr Gln Val Phe Glu Gln Ile Pro 
    370                 375                 380                 


Lys Ile Met Leu Asp Leu Tyr Phe Ser Ala Leu Asp 
385                 390                 395     


