                         SEQUENCE LISTING

<110>  Innovative Cellular Therapeutics Holdings Limited
       Innovative Cellular Therapeutics, Inc
 
<120>  Fusion Protein and Cell Therapy Thereof

<130>  SDS1.0080US

<150>  63/076,707
<151>  2020-09-10

<150>  63/081,675
<151>  2020-09-22

<150>  63/132,057
<151>  2020-12-30

<150>  63/071,785
<151>  2020-08-28

<160>  131   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  2
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  2

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr 
65                  


<210>  3
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  4

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  5
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  6
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  6

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  7
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Val Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala 
        115                 120                 125             


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser 
    130                 135                 140                 


Gly Phe Asn Ile Asn Asp Thr Tyr Met His Trp Val Lys Gln Arg Pro 
145                 150                 155                 160 


Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn 
                165                 170                 175     


Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp 
            180                 185                 190         


Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu 
        195                 200                 205             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Arg Gly Ser Arg Phe 
    210                 215                 220                 


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
225                 230                 235         


<210>  8
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  8

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asp Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Ala Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Arg Leu 
                85                  90                  95      


Gly Ile Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Gln Ser Leu Lys 
    130                 135                 140                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Leu Thr Asp Asn Trp Ile Gly 
145                 150                 155                 160 


Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile 
                165                 170                 175     


Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln 
            180                 185                 190         


Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr Leu Gln Trp 
        195                 200                 205             


Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys Val Gly Leu 
    210                 215                 220                 


Asp Trp Asn Tyr Asn Pro Leu Arg Tyr Trp Gly Pro Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  9
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  9

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Thr Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Gly 
                85                  90                  95      


Glu Leu Pro Pro Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
    130                 135                 140                 


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 
145                 150                 155                 160 


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
                165                 170                 175     


Ala Thr Val Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Ser Ala Met Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg His Arg Gly Asn Tyr Tyr Ala Thr Tyr Tyr Tyr Ala Met Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250         


<210>  10
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  10

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His His Glu Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Trp Met Asn Trp Val Lys 
145                 150                 155                 160 


Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
                165                 170                 175     


Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Pro Tyr Tyr 
    210                 215                 220                 


Gly Thr Asn Pro Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  11
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Lys Thr Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Arg 
                165                 170                 175     


Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg Gly Tyr Thr 
    210                 215                 220                 


Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  12
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Arg Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
145                 150                 155                 160 


Tyr Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ala 
                245     


<210>  13
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg 
1               5                   10                  15      


Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu 
            20                  25                  30          


Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg 
        35                  40                  45              


Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala 
    50                  55                  60                  


Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe 
65                  70                  75                  80  


Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr 
                85                  90                  95      


His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile 
            100                 105                 110         


Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu 
        115                 120                 125             


Gly Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn 
    130                 135                 140                 


Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp 
145                 150                 155                 160 


Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg 
                165                 170                 175     


Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg 
            180                 185                 190         


Ile Ile His Asn Asn Asn Cys 
        195                 


<210>  14
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Thr Gln 
                85                  90                  95      


Ser Phe Ile Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
    130                 135                 140                 


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
145                 150                 155                 160 


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Thr Gln 
    210                 215                 220                 


Ser Phe Ile Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  15
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Met Asn Val Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Gly Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Glu Glu Ile Val Thr Ile Thr Cys Lys Ala Ser Gln Ala 
        35                  40                  45              


Ile Asp Ala Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Ile Tyr Asp Ala Thr Ser Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser 
                85                  90                  95      


Arg Pro Gln Val Asp Asp Ser Gly Ile Tyr Tyr Cys Leu Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    130                 135                 140                 


Ala Val Leu Val Leu Leu Leu Cys Leu Leu Ile Phe Pro Ser Cys Val 
145                 150                 155                 160 


Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro 
                165                 170                 175     


Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Leu Thr 
            180                 185                 190         


Ser Asn Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Met Gly Val Ile Trp Ser Asn Gly Asp Ala Asp Tyr Asn Ser Ala 
    210                 215                 220                 


Ile Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val 
225                 230                 235                 240 


Phe Leu Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe 
                245                 250                 255     


Cys Ala Ser Pro Tyr Tyr Gly Tyr Tyr Phe Pro Phe Asp Tyr Trp Gly 
            260                 265                 270         


Gln Gly Val Met Val Thr Val Ser Ser 
        275                 280     


<210>  16
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Ser Ile Ser Ser His Asp Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Gln Pro Lys Leu Leu Ile Tyr Asp Ala Phe Asn Leu Ala Ser Gly 
65                  70                  75                  80  


Ile Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Asp Pro Val Gln Ala Asp Asp Ile Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Ser Lys Asp Asp Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Met Asp Ile Arg Leu Ser Leu Ala Phe Leu Val Leu Phe Ile 
145                 150                 155                 160 


Lys Gly Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                165                 170                 175     


Val Gln Pro Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe 
            180                 185                 190         


Thr Phe Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys 
        195                 200                 205             


Gly Leu Glu Trp Val Ala Thr Ile Ser Tyr Asp Gly Ser Ile Thr Tyr 
    210                 215                 220                 


Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ala 
225                 230                 235                 240 


Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr 
                245                 250                 255     


Ala Thr Tyr Tyr Cys Thr Arg Glu Glu Gln Tyr Ser Ser Trp Tyr Phe 
            260                 265                 270         


Asp Phe Trp Gly Pro Gly Ile Met Val Thr Val Ser Ser 
        275                 280                 285 


<210>  17
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Asn Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys His Gln Tyr Asn Ser Tyr Asn Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Thr Leu Lys Glu 
        115                 120                 125             


Ser Gly Pro Val Leu Val Lys Pro Thr Glu Thr Leu Thr Leu Thr Cys 
    130                 135                 140                 


Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp 
145                 150                 155                 160 


Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala His Ile Trp 
                165                 170                 175     


Trp Asp Asp Asp Val Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr 
            180                 185                 190         


Ile Thr Lys Asp Ala Ser Lys Asp Gln Val Ser Leu Lys Leu Ser Ser 
        195                 200                 205             


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val Arg Arg Arg Ala 
    210                 215                 220                 


Thr Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  18
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  18
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gaggcgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  19
<211>  1689
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19
cggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg       60

gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag      120

tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc      180

agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggatccgcc      240

accatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc      300

aggccggaca tccagctcac ccagtccccg agctcgctgt ccgcctccgt gggagatcgg      360

gtcaccatca cgtgccgcgc cagccagtcg atttcctcct acctgaactg gtaccaacag      420

aagcccggaa aagccccgaa gcttctcatc tacgccgcct cgagcctgca gtcaggagtg      480

ccctcacggt tctccggctc cggttccggt actgatttca ccctgaccat ttcctccctg      540

caaccggagg acttcgctac ttactactgc cagcagtcgt actccacccc ctacactttc      600

ggacaaggca ccaaggtcga aatcaagggt ggcggtggct cgggcggtgg tgggtcgggt      660

ggcggcggat ctgaagtgca attggtggaa tcagggggag gacttgtgca gcctggagga      720

tcgctgagac tgtcatgtgc cgtgtccggc tttgccctgt ccaaccacgg gatgtcctgg      780

gtccgccgcg cgcctggaaa gggcctcgaa tgggtgtcgg gtattgtgta cagcggtagc      840

acctactatg ccgcatccgt gaaggggaga ttcaccatca gccgggacaa ctccaggaac      900

actctgtacc tccaaatgaa ttcgctgagg ccagaggaca ctgccatcta ctactgctcc      960

gcgcatggcg gagagtccga cgtctgggga caggggacca ccgtgaccgt gtctagcacc     1020

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc     1080

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac     1140

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg     1200

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     1260

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1320

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1380

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1440

gagtacgatg ttttggacaa gaggcgtggc cgggaccctg agatgggggg aaagccgaga     1500

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1560

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1620

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1680

cctcgctaa                                                             1689


<210>  20
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agctcaccca gtccccgagc tcgctgtccg cctccgtggg agatcgggtc      120

accatcacgt gccgcgccag ccagtcgatt tcctcctacc tgaactggta ccaacagaag      180

cccggaaaag ccccgaagct tctcatctac gccgcctcga gcctgcagtc aggagtgccc      240

tcacggttct ccggctccgg ttccggtact gatttcaccc tgaccatttc ctccctgcaa      300

ccggaggact tcgctactta ctactgccag cagtcgtact ccacccccta cactttcgga      360

caaggcacca aggtcgaaat caagggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aagtgcaatt ggtggaatca gggggaggac ttgtgcagcc tggaggatcg      480

ctgagactgt catgtgccgt gtccggcttt gccctgtcca accacgggat gtcctgggtc      540

cgccgcgcgc ctggaaaggg cctcgaatgg gtgtcgggta ttgtgtacag cggtagcacc      600

tactatgccg catccgtgaa ggggagattc accatcagcc gggacaactc caggaacact      660

ctgtacctcc aaatgaattc gctgaggcca gaggacactg ccatctacta ctgctccgcg      720

catggcggag agtccgacgt ctggggacag gggaccaccg tgaccgtgtc tagcaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgctaa                                                                1446


<210>  21
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg      120

acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg      180

acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca      240

agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg      300

accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc      360

taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc      420

ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg      480

gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac      540

cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt      600

agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc      660

gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc      720

gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc      780

ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1020

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1080

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctaa                                         1467


<210>  22
<211>  3533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagaggcgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta atctagaggc gcgcccctct ccctcccccc cccctaacgt     1500

tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac     1560

catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag     1620

cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa     1680

ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag     1740

gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga     1800

tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag     1860

agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc     1920

ccattgtatg ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag     1980

gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg     2040

atgataatat ggccacaacc catatgatgg ccttaccagt gaccgccttg ctcctgccgc     2100

tggccttgct gctccacgcc gccaggccgg acatcgtgat gacccagtcc ccctccagcc     2160

tgacagtgac agccggcgag aaggtgacaa tgatctgtaa gtccagccag agcctgctga     2220

acagcggcga ccagaagaac tacctgacct ggtaccagca gaagcctggc cagcccccca     2280

agctgctgat cttctgggcc agcacaaggg agagcggcgt gcccgacaga ttcacaggca     2340

gcggcagcgg caccgacttc acactgacca tttcctccgt gcaggccgag gacctcgccg     2400

tgtactactg ccagaacgac tactcctacc ccctgacatt cggcgccggc accaaactgg     2460

agctgaaggg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga tctcaggtgc     2520

agctccagca gtccgatgcc gagctggtga agcccggaag cagcgtcaag atcagctgta     2580

aggcctccgg ctacaccttc acagaccacg ccatccactg ggtgaagcag aagcccgagc     2640

agggcctgga gtggatcggc cactttagcc ccggaaacac cgacatcaag tacaacgaca     2700

agttcaaggg caaggccacc ctgaccgtgg acaggagcag cagcaccgcc tacatgcagc     2760

tgaacagcct gacaagcgag gacagcgccg tgtacttctg caagacctcc accttcttct     2820

tcgactactg gggccaggga accaccctga cagtgtccag caccacgacg ccagcgccgc     2880

gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt     2940

gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct     3000

acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc     3060

tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac     3120

cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag     3180

gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg tacaagcagg     3240

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     3300

acaagaggcg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg     3360

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     3420

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     3480

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taa            3533


<210>  23
<211>  3533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatatcc agatgaccca gagcccgagc agcctgagcg cgagcgtggg tgatcgcgtg      120

accattacct gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccgggtaaag cgccgaaact gttaatttat catacatcaa gattacactc aggcgtgccg      240

tcgcgtttta gcggctcggg ttcgggcacc gattttaccc tgaccatctc gagcttgcag      300

ccggaggact tcgccaccta ctattgccaa cagggtaata cgcttccgta cacgttcggt      360

cagggcacca aagtggagat caaaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgcagct ggtggagtct gggggaggct tggtacagcc tggggggtcc      480

ctgagactct cctgtgcagc ctctggagtg tccctgcctg attatggcgt gtcctgggtc      540

cgccaggctc cagggaaggg gctggagtgg gtttcagtga tctggggcag cgagacaacc      600

tactacaaca gcgccctgaa gtcccgattc accatctcca gagacaatgc caagaactca      660

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaag      720

cactactact acggcggcag ctacgctatg gactactggg gccaaggaac cctggtcacc      780

gtgtcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagaggcgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta atctagaggc gcgcccctct ccctcccccc cccctaacgt     1500

tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac     1560

catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag     1620

cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa     1680

ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag     1740

gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga     1800

tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag     1860

agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc     1920

ccattgtatg ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag     1980

gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg     2040

atgataatat ggccacaacc catatgatgg ccttaccagt gaccgccttg ctcctgccgc     2100

tggccttgct gctccacgcc gccaggccgg acatcgtgat gacccagtcc ccctccagcc     2160

tgacagtgac agccggcgag aaggtgacaa tgatctgtaa gtccagccag agcctgctga     2220

acagcggcga ccagaagaac tacctgacct ggtaccagca gaagcctggc cagcccccca     2280

agctgctgat cttctgggcc agcacaaggg agagcggcgt gcccgacaga ttcacaggca     2340

gcggcagcgg caccgacttc acactgacca tttcctccgt gcaggccgag gacctcgccg     2400

tgtactactg ccagaacgac tactcctacc ccctgacatt cggcgccggc accaaactgg     2460

agctgaaggg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga tctcaggtgc     2520

agctccagca gtccgatgcc gagctggtga agcccggaag cagcgtcaag atcagctgta     2580

aggcctccgg ctacaccttc acagaccacg ccatccactg ggtgaagcag aagcccgagc     2640

agggcctgga gtggatcggc cactttagcc ccggaaacac cgacatcaag tacaacgaca     2700

agttcaaggg caaggccacc ctgaccgtgg acaggagcag cagcaccgcc tacatgcagc     2760

tgaacagcct gacaagcgag gacagcgccg tgtacttctg caagacctcc accttcttct     2820

tcgactactg gggccaggga accaccctga cagtgtccag caccacgacg ccagcgccgc     2880

gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt     2940

gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct     3000

acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc     3060

tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac     3120

cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag     3180

gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg tacaagcagg     3240

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     3300

acaagaggcg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg     3360

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     3420

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     3480

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taa            3533


<210>  24
<211>  3545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatatcc agatgaccca gagcccaagc tccctgtccg cctctgtggg cgacagggtg      120

accatcacat gccgcgccag ccagacaatc tggtcctacc tgaactggta tcagcagaga      180

cccggcaagg cccctaatct gctgatctac gcagcatcta gcctgcagtc tggagtgccc      240

tcccggttct ctggaagagg atccggaacc gacttcaccc tgacaatctc ctctctgcag      300

gccgaggact tcgccacata ctattgccag cagagctatt ccatccctca gacctttggc      360

cagggcacaa agctggagat caagggcggc ggcggctctg gaggaggagg aagcggagga      420

ggaggatccc aggtgcagct gcagcagagc ggaccaggac tggtgaagcc ctcccagacc      480

ctgtctctga catgtgccat cagcggcgat tccgtgagct ccaacagcgc cgcctggaat      540

tggatccggc agtctcccag cagaggactg gagtggctgg gaaggaccta ctatcgctcc      600

aagtggtaca acgattatgc cgtgtctgtg aagagccgga tcaccatcaa ccctgacaca      660

tctaagaatc agttcagcct gcagctgaat tccgtgaccc cagaggacac agccgtgtac      720

tattgtgcaa gggaggtgac cggcgacctg gaggatgcct ttgacatctg gggccagggc      780

accatggtga cagtgtctag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagaggcg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taatctagag gcgcgcccct ctccctcccc     1500

cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat     1560

gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt     1620

cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt     1680

gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc     1740

gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg gccaaaagcc     1800

acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat     1860

agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc     1920

ccagaaggta ccccattgta tgggatctga tctggggcct cggtacacat gctttacatg     1980

tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct     2040

ttgaaaaaca cgatgataat atggccacaa cccatatgat ggccttacca gtgaccgcct     2100

tgctcctgcc gctggccttg ctgctccacg ccgccaggcc ggacatcgtg atgacccagt     2160

ccccctccag cctgacagtg acagccggcg agaaggtgac aatgatctgt aagtccagcc     2220

agagcctgct gaacagcggc gaccagaaga actacctgac ctggtaccag cagaagcctg     2280

gccagccccc caagctgctg atcttctggg ccagcacaag ggagagcggc gtgcccgaca     2340

gattcacagg cagcggcagc ggcaccgact tcacactgac catttcctcc gtgcaggccg     2400

aggacctcgc cgtgtactac tgccagaacg actactccta ccccctgaca ttcggcgccg     2460

gcaccaaact ggagctgaag ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg     2520

gatctcaggt gcagctccag cagtccgatg ccgagctggt gaagcccgga agcagcgtca     2580

agatcagctg taaggcctcc ggctacacct tcacagacca cgccatccac tgggtgaagc     2640

agaagcccga gcagggcctg gagtggatcg gccactttag ccccggaaac accgacatca     2700

agtacaacga caagttcaag ggcaaggcca ccctgaccgt ggacaggagc agcagcaccg     2760

cctacatgca gctgaacagc ctgacaagcg aggacagcgc cgtgtacttc tgcaagacct     2820

ccaccttctt cttcgactac tggggccagg gaaccaccct gacagtgtcc agcaccacga     2880

cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc     2940

gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg     3000

cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac     3060

tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata ttcaaacaac     3120

catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag     3180

aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg     3240

cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt     3300

acgatgtttt ggacaagagg cgtggccggg accctgagat ggggggaaag ccgagaagga     3360

agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca     3420

gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg     3480

gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc     3540

gctaa                                                                 3545


<210>  25
<211>  3518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agctcaccca gtccccgagc tcgctgtccg cctccgtggg agatcgggtc      120

accatcacgt gccgcgccag ccagtcgatt tcctcctacc tgaactggta ccaacagaag      180

cccggaaaag ccccgaagct tctcatctac gccgcctcga gcctgcagtc aggagtgccc      240

tcacggttct ccggctccgg ttccggtact gatttcaccc tgaccatttc ctccctgcaa      300

ccggaggact tcgctactta ctactgccag cagtcgtact ccacccccta cactttcgga      360

caaggcacca aggtcgaaat caagggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aagtgcaatt ggtggaatca gggggaggac ttgtgcagcc tggaggatcg      480

ctgagactgt catgtgccgt gtccggcttt gccctgtcca accacgggat gtcctgggtc      540

cgccgcgcgc ctggaaaggg cctcgaatgg gtgtcgggta ttgtgtacag cggtagcacc      600

tactatgccg catccgtgaa ggggagattc accatcagcc gggacaactc caggaacact      660

ctgtacctcc aaatgaattc gctgaggcca gaggacactg ccatctacta ctgctccgcg      720

catggcggag agtccgacgt ctggggacag gggaccaccg tgaccgtgtc tagcaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgctaatcta gaggcgcgcc cctctccctc ccccccccct aacgttactg gccgaagccg     1500

cttggaataa ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt     1560

tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct     1620

ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct     1680

ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc     1740

acctggcgac aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc     1800

ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc     1860

ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc     1920

tgatctgggg cctcggtaca catgctttac atgtgtttag tcgaggttaa aaaaacgtct     1980

aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgatgat aatatggcca     2040

caacccatat gatggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc     2100

acgccgccag gccggacatc gtgatgaccc agtccccctc cagcctgaca gtgacagccg     2160

gcgagaaggt gacaatgatc tgtaagtcca gccagagcct gctgaacagc ggcgaccaga     2220

agaactacct gacctggtac cagcagaagc ctggccagcc ccccaagctg ctgatcttct     2280

gggccagcac aagggagagc ggcgtgcccg acagattcac aggcagcggc agcggcaccg     2340

acttcacact gaccatttcc tccgtgcagg ccgaggacct cgccgtgtac tactgccaga     2400

acgactactc ctaccccctg acattcggcg ccggcaccaa actggagctg aagggtggcg     2460

gtggctcggg cggtggtggg tcgggtggcg gcggatctca ggtgcagctc cagcagtccg     2520

atgccgagct ggtgaagccc ggaagcagcg tcaagatcag ctgtaaggcc tccggctaca     2580

ccttcacaga ccacgccatc cactgggtga agcagaagcc cgagcagggc ctggagtgga     2640

tcggccactt tagccccgga aacaccgaca tcaagtacaa cgacaagttc aagggcaagg     2700

ccaccctgac cgtggacagg agcagcagca ccgcctacat gcagctgaac agcctgacaa     2760

gcgaggacag cgccgtgtac ttctgcaaga cctccacctt cttcttcgac tactggggcc     2820

agggaaccac cctgacagtg tccagcacca cgacgccagc gccgcgacca ccaacaccgg     2880

cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg     2940

ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct     3000

tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac tgcaaacggg     3060

gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta caaactactc     3120

aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga tgtgaactga     3180

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag aaccagctct     3240

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag aggcgtggcc     3300

gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg     3360

aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc     3420

ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct     3480

acgacgccct tcacatgcag gccctgcccc ctcgctaa                             3518


<210>  26
<211>  2994
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  26
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagaggcgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgctc tagagccacg aacttctctc tgttaaagca agcaggagac     1500

gtggaagaaa accccggtcc tcatatgatg gccttaccag tgaccgcctt gctcctgccg     1560

ctggccttgc tgctccacgc cgccaggccg gacatcgtga tgacccagtc cccctccagc     1620

ctgacagtga cagccggcga gaaggtgaca atgatctgta agtccagcca gagcctgctg     1680

aacagcggcg accagaagaa ctacctgacc tggtaccagc agaagcctgg ccagcccccc     1740

aagctgctga tcttctgggc cagcacaagg gagagcggcg tgcccgacag attcacaggc     1800

agcggcagcg gcaccgactt cacactgacc atttcctccg tgcaggccga ggacctcgcc     1860

gtgtactact gccagaacga ctactcctac cccctgacat tcggcgccgg caccaaactg     1920

gagctgaagg gtggcggtgg ctcgggcggt ggtgggtcgg gtggcggcgg atctcaggtg     1980

cagctccagc agtccgatgc cgagctggtg aagcccggaa gcagcgtcaa gatcagctgt     2040

aaggcctccg gctacacctt cacagaccac gccatccact gggtgaagca gaagcccgag     2100

cagggcctgg agtggatcgg ccactttagc cccggaaaca ccgacatcaa gtacaacgac     2160

aagttcaagg gcaaggccac cctgaccgtg gacaggagca gcagcaccgc ctacatgcag     2220

ctgaacagcc tgacaagcga ggacagcgcc gtgtacttct gcaagacctc caccttcttc     2280

ttcgactact ggggccaggg aaccaccctg acagtgtcca gcaccacgac gccagcgccg     2340

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     2400

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     2460

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     2520

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     2580

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     2640

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     2700

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     2760

gacaagaggc gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     2820

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     2880

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     2940

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           2994


<210>  27
<211>  2994
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  27
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatatcc agatgaccca gagcccgagc agcctgagcg cgagcgtggg tgatcgcgtg      120

accattacct gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccgggtaaag cgccgaaact gttaatttat catacatcaa gattacactc aggcgtgccg      240

tcgcgtttta gcggctcggg ttcgggcacc gattttaccc tgaccatctc gagcttgcag      300

ccggaggact tcgccaccta ctattgccaa cagggtaata cgcttccgta cacgttcggt      360

cagggcacca aagtggagat caaaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgcagct ggtggagtct gggggaggct tggtacagcc tggggggtcc      480

ctgagactct cctgtgcagc ctctggagtg tccctgcctg attatggcgt gtcctgggtc      540

cgccaggctc cagggaaggg gctggagtgg gtttcagtga tctggggcag cgagacaacc      600

tactacaaca gcgccctgaa gtcccgattc accatctcca gagacaatgc caagaactca      660

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaag      720

cactactact acggcggcag ctacgctatg gactactggg gccaaggaac cctggtcacc      780

gtgtcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagaggcgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgctc tagagccacg aacttctctc tgttaaagca agcaggagac     1500

gtggaagaaa accccggtcc tcatatgatg gccttaccag tgaccgcctt gctcctgccg     1560

ctggccttgc tgctccacgc cgccaggccg gacatcgtga tgacccagtc cccctccagc     1620

ctgacagtga cagccggcga gaaggtgaca atgatctgta agtccagcca gagcctgctg     1680

aacagcggcg accagaagaa ctacctgacc tggtaccagc agaagcctgg ccagcccccc     1740

aagctgctga tcttctgggc cagcacaagg gagagcggcg tgcccgacag attcacaggc     1800

agcggcagcg gcaccgactt cacactgacc atttcctccg tgcaggccga ggacctcgcc     1860

gtgtactact gccagaacga ctactcctac cccctgacat tcggcgccgg caccaaactg     1920

gagctgaagg gtggcggtgg ctcgggcggt ggtgggtcgg gtggcggcgg atctcaggtg     1980

cagctccagc agtccgatgc cgagctggtg aagcccggaa gcagcgtcaa gatcagctgt     2040

aaggcctccg gctacacctt cacagaccac gccatccact gggtgaagca gaagcccgag     2100

cagggcctgg agtggatcgg ccactttagc cccggaaaca ccgacatcaa gtacaacgac     2160

aagttcaagg gcaaggccac cctgaccgtg gacaggagca gcagcaccgc ctacatgcag     2220

ctgaacagcc tgacaagcga ggacagcgcc gtgtacttct gcaagacctc caccttcttc     2280

ttcgactact ggggccaggg aaccaccctg acagtgtcca gcaccacgac gccagcgccg     2340

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     2400

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     2460

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     2520

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     2580

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     2640

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     2700

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     2760

gacaagaggc gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     2820

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     2880

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     2940

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           2994


<210>  28
<211>  3009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatatcc agatgaccca gagcccaagc tccctgtccg cctctgtggg cgacagggtg      120

accatcacat gccgcgccag ccagacaatc tggtcctacc tgaactggta tcagcagaga      180

cccggcaagg cccctaatct gctgatctac gcagcatcta gcctgcagtc tggagtgccc      240

tcccggttct ctggaagagg atccggaacc gacttcaccc tgacaatctc ctctctgcag      300

gccgaggact tcgccacata ctattgccag cagagctatt ccatccctca gacctttggc      360

cagggcacaa agctggagat caagggcggc ggcggctctg gaggaggagg aagcggagga      420

ggaggatccc aggtgcagct gcagcagagc ggaccaggac tggtgaagcc ctcccagacc      480

ctgtctctga catgtgccat cagcggcgat tccgtgagct ccaacagcgc cgcctggaat      540

tggatccggc agtctcccag cagaggactg gagtggctgg gaaggaccta ctatcgctcc      600

aagtggtaca acgattatgc cgtgtctgtg aagagccgga tcaccatcaa ccctgacaca      660

tctaagaatc agttcagcct gcagctgaat tccgtgaccc cagaggacac agccgtgtac      720

tattgtgcaa gggaggtgac cggcgacctg gaggatgcct ttgacatctg gggccagggc      780

accatggtga cagtgtctag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagaggcg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taatctagag ccacgaactt ctctctgtta     1500

aagcaagcag gagacgtgga agaaaacccc ggtcctcata tgatggcctt accagtgacc     1560

gccttgctcc tgccgctggc cttgctgctc cacgccgcca ggccggacat cgtgatgacc     1620

cagtccccct ccagcctgac agtgacagcc ggcgagaagg tgacaatgat ctgtaagtcc     1680

agccagagcc tgctgaacag cggcgaccag aagaactacc tgacctggta ccagcagaag     1740

cctggccagc cccccaagct gctgatcttc tgggccagca caagggagag cggcgtgccc     1800

gacagattca caggcagcgg cagcggcacc gacttcacac tgaccatttc ctccgtgcag     1860

gccgaggacc tcgccgtgta ctactgccag aacgactact cctaccccct gacattcggc     1920

gccggcacca aactggagct gaagggtggc ggtggctcgg gcggtggtgg gtcgggtggc     1980

ggcggatctc aggtgcagct ccagcagtcc gatgccgagc tggtgaagcc cggaagcagc     2040

gtcaagatca gctgtaaggc ctccggctac accttcacag accacgccat ccactgggtg     2100

aagcagaagc ccgagcaggg cctggagtgg atcggccact ttagccccgg aaacaccgac     2160

atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag gagcagcagc     2220

accgcctaca tgcagctgaa cagcctgaca agcgaggaca gcgccgtgta cttctgcaag     2280

acctccacct tcttcttcga ctactggggc cagggaacca ccctgacagt gtccagcacc     2340

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc     2400

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac     2460

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg     2520

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     2580

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     2640

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     2700

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     2760

gagtacgatg ttttggacaa gaggcgtggc cgggaccctg agatgggggg aaagccgaga     2820

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     2880

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     2940

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     3000

cctcgctaa                                                             3009


<210>  29
<211>  2982
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  29
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agctcaccca gtccccgagc tcgctgtccg cctccgtggg agatcgggtc      120

accatcacgt gccgcgccag ccagtcgatt tcctcctacc tgaactggta ccaacagaag      180

cccggaaaag ccccgaagct tctcatctac gccgcctcga gcctgcagtc aggagtgccc      240

tcacggttct ccggctccgg ttccggtact gatttcaccc tgaccatttc ctccctgcaa      300

ccggaggact tcgctactta ctactgccag cagtcgtact ccacccccta cactttcgga      360

caaggcacca aggtcgaaat caagggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aagtgcaatt ggtggaatca gggggaggac ttgtgcagcc tggaggatcg      480

ctgagactgt catgtgccgt gtccggcttt gccctgtcca accacgggat gtcctgggtc      540

cgccgcgcgc ctggaaaggg cctcgaatgg gtgtcgggta ttgtgtacag cggtagcacc      600

tactatgccg catccgtgaa ggggagattc accatcagcc gggacaactc caggaacact      660

ctgtacctcc aaatgaattc gctgaggcca gaggacactg ccatctacta ctgctccgcg      720

catggcggag agtccgacgt ctggggacag gggaccaccg tgaccgtgtc tagcaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgctaatcta gagccacgaa cttctctctg ttaaagcaag caggagacgt ggaagaaaac     1500

cccggtcctc atatgatggc cttaccagtg accgccttgc tcctgccgct ggccttgctg     1560

ctccacgccg ccaggccgga catcgtgatg acccagtccc cctccagcct gacagtgaca     1620

gccggcgaga aggtgacaat gatctgtaag tccagccaga gcctgctgaa cagcggcgac     1680

cagaagaact acctgacctg gtaccagcag aagcctggcc agccccccaa gctgctgatc     1740

ttctgggcca gcacaaggga gagcggcgtg cccgacagat tcacaggcag cggcagcggc     1800

accgacttca cactgaccat ttcctccgtg caggccgagg acctcgccgt gtactactgc     1860

cagaacgact actcctaccc cctgacattc ggcgccggca ccaaactgga gctgaagggt     1920

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctcaggtgca gctccagcag     1980

tccgatgccg agctggtgaa gcccggaagc agcgtcaaga tcagctgtaa ggcctccggc     2040

tacaccttca cagaccacgc catccactgg gtgaagcaga agcccgagca gggcctggag     2100

tggatcggcc actttagccc cggaaacacc gacatcaagt acaacgacaa gttcaagggc     2160

aaggccaccc tgaccgtgga caggagcagc agcaccgcct acatgcagct gaacagcctg     2220

acaagcgagg acagcgccgt gtacttctgc aagacctcca ccttcttctt cgactactgg     2280

ggccagggaa ccaccctgac agtgtccagc accacgacgc cagcgccgcg accaccaaca     2340

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg     2400

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg     2460

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     2520

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     2580

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     2640

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     2700

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagaggcgt     2760

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     2820

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     2880

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     2940

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        2982


<210>  30
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser 
    130                 135                 140                 


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
145                 150                 155                 160 


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe 
            180                 185                 190         


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
    210                 215                 220                 


Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  31
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  31

Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  32
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  32

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  33
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  33

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn 
145                 150                 155                 160 


Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala 
            180                 185                 190         


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser 
        195                 200                 205             


Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile 
    210                 215                 220                 


Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Leu Thr Val Ser Ser 
                245     


<210>  34
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  34

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  35
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  35

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala 
        


<210>  36
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  36
atggttcgtc tgcctctgca gtgcgtcctc tggggctgct tgctgaccgc tgtccatcca       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

aaatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccccaggat cggctgagat gtccaagtcc cctatttccc      600

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      660

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg      720

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag      780

ccctatgccc caccacgcga cttcgcagcc tatcgctcct ag                         822


<210>  37
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  37

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
        195                 200                 205             


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    210                 215                 220                 


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
225                 230                 235                 240 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                245                 250                 255     


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            260                 265                 270         


Ser 
    


<210>  38
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln 
            180                 185     


<210>  39
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  39

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  40
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  40

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu 
        35          


<210>  41
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg 
    


<210>  42
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile Leu 
1               5                   10                  15      


Leu Val Leu Val Phe Ile 
            20          


<210>  43
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  43

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  44
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln 
            180                 185     


<210>  45
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  45

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  46
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  46

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  47
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr 
                645                 650         


<210>  48
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  48

Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly 
1               5                   10                  15      


Val Val Phe Gly Ile Leu Ile 
            20              


<210>  49
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  49

Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu 
1               5                   10                  15      


Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro 
            20                  25                  30          


Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val 
        35                  40                  45              


Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp 
    50                  55                  60                  


Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu 
65                  70                  75                  80  


Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala 
                85                  90                  95      


Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly 
            100                 105                 110         


Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr 
        115                 120                 125             


Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu Gly Ser 
    130                 135                 140                 


Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met Ser Tyr 
145                 150                 155                 160 


Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val 
                165                 170                 175     


Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu Ala 
            180                 185                 190         


Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly Gly Lys 
        195                 200                 205             


Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe 
    210                 215                 220                 


Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu 
225                 230                 235                 240 


Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg Glu Ile 
                245                 250                 255     


Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys 
            260                 265                 270         


Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ser 
        275                 280                 285             


Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser Arg Met 
    290                 295                 300                 


Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp Leu Gly 
305                 310                 315                 320 


Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu Leu Glu Asp 
                325                 330                 335     


Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu Val Pro Gln 
            340                 345                 350         


Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly Gly Met Val 
        355                 360                 365             


His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly Gly Asp Leu 
    370                 375                 380                 


Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg Ser Pro Leu 
385                 390                 395                 400 


Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly Asp Leu Gly 
                405                 410                 415     


Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His Asp Pro Ser 
            420                 425                 430         


Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu Pro Ser Glu 
        435                 440                 445             


Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln Pro Glu Tyr 
    450                 455                 460                 


Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro Arg Glu Gly 
465                 470                 475                 480 


Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu Arg Pro Lys 
                485                 490                 495     


Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val Phe Ala Phe 
            500                 505                 510         


Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln Gly Gly Ala 
        515                 520                 525             


Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala Phe Asp Asn 
    530                 535                 540                 


Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala Pro Pro Ser 
545                 550                 555                 560 


Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr Leu Gly Leu 
                565                 570                 575     


Asp Val Pro Val 
            580 


<210>  50
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro 
        


<210>  51
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  51

Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys Val Leu 
1               5                   10                  15      


Leu Leu Thr Ser Ala 
            20      


<210>  52
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  53
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro 
145                 150         


<210>  54
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  54

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  55
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  55

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  56
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys 
    130                 135                 140 


<210>  57
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  57

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  58
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  58

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  59
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Met Ile Ile Ser Met Trp Met Ser Ile Ser Arg Gly Leu Trp Asp 
1               5                   10                  15      


Ser Ser Ser Ile Trp Ser Val Leu Leu Ile Leu Ala Cys Met Ala Ser 
            20                  25                  30          


Ile Thr Thr Ser Ser Ser Val Ser Asn Ala Gly Tyr Val Asp Asn Gly 
        35                  40                  45              


Asn Met Lys Val Cys Ile Gly Thr Lys Ser Arg Leu Ser Val Pro Ser 
    50                  55                  60                  


Asn Lys Glu His His Tyr Arg Asn Leu Arg Asp Arg Tyr Thr Asn Cys 
65                  70                  75                  80  


Thr Tyr Val Asp Gly Asn Leu Glu Leu Thr Trp Leu Pro Asn Glu Asn 
                85                  90                  95      


Leu Asp Leu Ser Phe Leu Asp Asn Ile Arg Glu Val Thr Gly Tyr Ile 
            100                 105                 110         


Leu Ile Ser His Val Asp Val Lys Lys Val Val Phe Pro Lys Leu Gln 
        115                 120                 125             


Ile Ile Arg Gly Arg Thr Leu Phe Ser Leu Ser Val Glu Glu Glu Lys 
    130                 135                 140                 


Tyr Ala Leu Phe Val Thr Tyr Ser Lys Met Tyr Thr Leu Glu Ile Pro 
145                 150                 155                 160 


Asp Leu Arg Asp Val Leu Asn Gly Gln Val Gly Phe His Asn Asn Tyr 
                165                 170                 175     


Asn Leu Cys His Met Arg Thr Ile Gln Trp Ser Glu Ile Val Ser Asn 
            180                 185                 190         


Gly Thr Asp Ala Tyr Tyr Asn Tyr Asp Phe Thr Ala Pro Glu Arg Glu 
        195                 200                 205             


Cys Pro Lys Cys His Glu Ser Cys Thr His Gly Cys Trp Gly Glu Gly 
    210                 215                 220                 


Pro Lys Asn Cys Gln Lys Phe Ser Lys Leu Thr Cys Ser Pro Gln Cys 
225                 230                 235                 240 


Ala Gly Gly Arg Cys Tyr Gly Pro Lys Pro Arg Glu Cys Cys His Leu 
                245                 250                 255     


Phe Cys Ala Gly Gly Cys Thr Gly Pro Thr Gln Lys Asp Cys Ile Ala 
            260                 265                 270         


Cys Lys Asn Phe Phe Asp Glu Gly Val Cys Lys Glu Glu Cys Pro Pro 
        275                 280                 285             


Met Arg Lys Tyr Asn Pro Thr Thr Tyr Val Leu Glu Thr Asn Pro Glu 
    290                 295                 300                 


Gly Lys Tyr Ala Tyr Gly Ala Thr Cys Val Lys Glu Cys Pro Gly His 
305                 310                 315                 320 


Leu Leu Arg Asp Asn Gly Ala Cys Val Arg Ser Cys Pro Gln Asp Lys 
                325                 330                 335     


Met Asp Lys Gly Gly Glu Cys Val Pro Cys Asn Gly Pro Cys Pro Lys 
            340                 345                 350         


Thr Cys Pro Gly Val Thr Val Leu His Ala Gly Asn Ile Asp Ser Phe 
        355                 360                 365             


Arg Asn Cys Thr Val Ile Asp Gly Asn Ile Arg Ile Leu Asp Gln Thr 
    370                 375                 380                 


Phe Ser Gly Phe Gln Asp Val Tyr Ala Asn Tyr Thr Met Gly Pro Arg 
385                 390                 395                 400 


Tyr Ile Pro Leu Asp Pro Glu Arg Leu Glu Val Phe Ser Thr Val Lys 
                405                 410                 415     


Glu Ile Thr Gly Tyr Leu Asn Ile Glu Gly Thr His Pro Gln Phe Arg 
            420                 425                 430         


Asn Leu Ser Tyr Phe Arg Asn Leu Glu Thr Ile His Gly Arg Gln Leu 
        435                 440                 445             


Met Glu Ser Met Phe Ala Ala Leu Ala Ile Val Lys Ser Ser Leu Tyr 
    450                 455                 460                 


Ser Leu Glu Met Arg Asn Leu Lys Gln Ile Ser Ser Gly Ser Val Val 
465                 470                 475                 480 


Ile Gln His Asn Arg Asp Leu Cys Tyr Val Ser Asn Ile Arg Trp Pro 
                485                 490                 495     


Ala Ile Gln Lys Glu Pro Glu Gln Lys Val Trp Val Asn Glu Asn Leu 
            500                 505                 510         


Arg Ala Asp Leu Cys Glu Lys Asn Gly Thr Ile Cys Ser Asp Gln Cys 
        515                 520                 525             


Asn Glu Asp Gly Cys Trp Gly Ala Gly Thr Asp Gln Cys Leu Thr Cys 
    530                 535                 540                 


Lys Asn Phe Asn Phe Asn Gly Thr Cys Ile Ala Asp Cys Gly Tyr Ile 
545                 550                 555                 560 


Ser Asn Ala Tyr Lys Phe Asp Asn Arg Thr Cys Lys Ile Cys His Pro 
                565                 570                 575     


Glu Cys Arg Thr Cys Asn Gly Ala Gly Ala Asp His Cys Gln Glu Cys 
            580                 585                 590         


Val His Val Arg Asp Gly Gln His Cys Val Ser Glu Cys Pro Lys Asn 
        595                 600                 605             


Lys Tyr Asn Asp Arg Gly Val Cys Arg Glu Cys His Ala Thr Cys Asp 
    610                 615                 620                 


Gly Cys Thr Gly Pro Lys Asp Thr Ile Gly Ile Gly Ala Cys Thr Thr 
625                 630                 635                 640 


Cys Asn Leu Ala Ile Ile Asn Asn Asp Ala Thr Val Lys Arg Cys Leu 
                645                 650                 655     


Leu Lys Asp Asp Lys Cys Pro Asp Gly Tyr Phe Trp Glu Tyr Val His 
            660                 665                 670         


Pro Gln Glu Gln Gly Ser Leu Lys Pro Leu Ala Gly Arg Ala Val Cys 
        675                 680                 685             


Arg Lys Cys His Pro Leu Cys Glu Leu Cys Thr Asn Tyr Gly Tyr His 
    690                 695                 700                 


Glu Gln Val Cys Ser Lys Cys Thr His Tyr Lys Arg Arg Glu Gln Cys 
705                 710                 715                 720 


Glu Thr Glu Cys Pro Ala Asp His Tyr Thr Asp Glu Glu Gln Arg Glu 
                725                 730                 735     


Cys Phe Gln Cys His Pro Glu Cys Asn Gly Cys Thr Gly Pro Gly Ala 
            740                 745                 750         


Asp Asp Cys Lys Ser Cys Arg Asn Phe Lys Leu Phe Asp Ala Asn Glu 
        755                 760                 765             


Thr Gly Pro Tyr Val Asn Ser Thr Met Phe Asn Cys Thr Ser Lys Cys 
    770                 775                 780                 


Pro Leu Glu Met Arg His Val Asn Tyr Gln Tyr Thr Ala Ile Gly Pro 
785                 790                 795                 800 


Tyr Cys Ala Ala Ser Pro Pro Arg Ser Ser Lys Ile Thr Ala Asn Leu 
                805                 810                 815     


Asp Val Asn 
            


<210>  60
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ile Phe Ile Ile Thr Gly Ala Val Leu Val Pro Thr Ile Cys Ile 
1               5                   10                  15      


Leu Cys Val Val Thr Tyr Ile Cys 
            20                  


<210>  61
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  61

Arg Gln Lys Gln Lys Ala Lys Lys Glu Thr Val Lys Met Thr Met Ala 
1               5                   10                  15      


Leu Ser Gly Cys Glu Asp Ser Glu Pro Leu Arg Pro Ser Asn Ile Gly 
            20                  25                  30          


Ala Asn Leu Cys Lys Leu Arg Ile Val Lys Asp Ala Glu Leu Arg Lys 
        35                  40                  45              


Gly Gly Val Leu Gly Met Gly Ala Phe Gly Arg Val Tyr Lys Gly Val 
    50                  55                  60                  


Trp Val Pro Glu Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Glu 
65                  70                  75                  80  


Leu Leu Lys Ser Thr Gly Ala Glu Ser Ser Glu Glu Phe Leu Arg Glu 
                85                  90                  95      


Ala Tyr Ile Met Ala Ser Val Glu His Val Asn Leu Leu Lys Leu Leu 
            100                 105                 110         


Ala Val Cys Met Ser Ser Gln Met Met Leu Ile Thr Gln Leu Met Pro 
        115                 120                 125             


Leu Gly Cys Leu Leu Asp Tyr Val Arg Asn Asn Arg Asp Lys Ile Gly 
    130                 135                 140                 


Ser Lys Ala Leu Leu Asn Trp Ser Thr Gln Ile Ala Lys Gly Met Ser 
145                 150                 155                 160 


Tyr Leu Glu Glu Lys Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
                165                 170                 175     


Val Leu Val Gln Thr Pro Ser Leu Val Lys Ile Thr Asp Phe Gly Leu 
            180                 185                 190         


Ala Lys Leu Leu Ser Ser Asp Ser Asn Glu Tyr Lys Ala Ala Gly Gly 
        195                 200                 205             


Lys Met Pro Ile Lys Trp Leu Ala Leu Glu Cys Ile Arg Asn Arg Val 
    210                 215                 220                 


Phe Thr Ser Lys Ser Asp Val Trp Ala Phe Gly Val Thr Ile Trp Glu 
225                 230                 235                 240 


Leu Leu Thr Phe Gly Gln Arg Pro His Glu Asn Ile Pro Ala Lys Asp 
                245                 250                 255     


Ile Pro Asp Leu Ile Glu Val Gly Leu Lys Leu Glu Gln Pro Glu Ile 
            260                 265                 270         


Cys Ser Leu Asp Ile Tyr Cys Thr Leu Leu Ser Cys Trp His Leu Asp 
        275                 280                 285             


Ala Ala Met Arg Pro Thr Phe Lys Gln Leu Thr Thr Val Phe Ala Glu 
    290                 295                 300                 


Phe Ala Arg Asp Pro Gly Arg Tyr Leu Ala Ile Pro Gly Asp Lys Phe 
305                 310                 315                 320 


Thr Arg Leu Pro Ala Tyr Thr Ser Gln Asp Glu Lys Asp Leu Ile Arg 
                325                 330                 335     


Lys Leu Ala Pro Thr Thr Asp Gly Ser Glu Ala Ile Ala Glu Pro Asp 
            340                 345                 350         


Asp Tyr Leu Gln Pro Lys Ala Ala Pro Gly Pro Ser His Arg Thr Asp 
        355                 360                 365             


Cys Thr Asp Glu Ile Pro Lys Leu Asn Arg Tyr Cys Lys Asp Pro Ser 
    370                 375                 380                 


Asn Lys Asn Ser Ser Thr Gly Asp Asp Glu Thr Asp Ser Ser Ala Arg 
385                 390                 395                 400 


Glu Val Gly Val Gly Asn Leu Arg Leu Asp Leu Pro Val Asp Glu Asp 
                405                 410                 415     


Asp Tyr Leu Met Pro Thr Cys Gln Pro Gly Pro Asn Asn Asn Asn Asn 
            420                 425                 430         


Ile Asn Asn Pro Asn Gln Asn Asn Met Ala Ala Val Gly Val Ala Ala 
        435                 440                 445             


Gly Tyr Met Asp Leu Ile Gly Val Pro Val Ser Val Asp Asn Pro Glu 
    450                 455                 460                 


Tyr Leu Leu Asn Ala Gln Thr Leu Gly Val Gly Glu Ser Pro Ile Pro 
465                 470                 475                 480 


Thr Gln Thr Ile Gly Ile Pro Val Met Gly Val Pro Gly Thr Met Glu 
                485                 490                 495     


Val Lys Val Pro Met Pro Gly Ser Glu Pro Thr Ser Ser Asp His Glu 
            500                 505                 510         


Tyr Tyr Asn Asp Thr Gln Arg Glu Leu Gln Pro Leu His Arg Asn Arg 
        515                 520                 525             


Asn Thr Glu Thr Arg Val 
    530                 


<210>  62
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg 
            180                 185                 190     


<210>  63
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  63

Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210>  64
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  65
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  65

Tyr Arg Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp 
1               5                   10                  15      


Glu Thr Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu 
            20                  25                  30          


Lys Glu Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu 
        35                  40                  45              


Ile Leu Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile 
    50                  55                  60                  


Phe Glu Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His 
65                  70                  75                  80  


Ser Leu Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser 
                85                  90                  95      


Tyr Met Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu 
            100                 105                 110         


Ala Leu Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro 
        115                 120                 125             


Val Thr Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser 
    130                 135                 140                 


His Arg Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser 
145                 150                 155                 160 


Arg Phe Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys 
                165                 170                 175     


Pro Gly Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
            180                 185                 190     


<210>  66
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  66

Asn Arg Ser Phe Arg Thr Gly Ile Lys Arg Arg Ile Leu Leu Leu Ile 
1               5                   10                  15      


Pro Lys Trp Leu Tyr Glu Asp Ile Pro Asn Met Lys Asn Ser Asn Val 
            20                  25                  30          


Val Lys Met Leu Gln Glu Asn Ser Glu Leu Met Asn Asn Asn Ser Ser 
        35                  40                  45              


Glu Gln Val Leu Tyr Val Asp Pro Met Ile Thr Glu Ile Lys Glu Ile 
    50                  55                  60                  


Phe Ile Pro Glu His Lys Pro Thr Asp Tyr Lys Lys Glu Asn Thr Gly 
65                  70                  75                  80  


Pro Leu Glu Thr Arg Asp Tyr Pro Gln Asn Ser Leu Phe Asp Asn Thr 
                85                  90                  95      


Thr Val Val Tyr Ile Pro Asp Leu Asn Thr Gly Tyr Lys Pro Gln Ile 
            100                 105                 110         


Ser Asn Phe Leu Pro Glu Gly Ser His Leu Ser Asn Asn Asn Glu Ile 
        115                 120                 125             


Thr Ser Leu Thr Leu Lys Pro Pro Val Asp Ser Leu Asp Ser Gly Asn 
    130                 135                 140                 


Asn Pro Arg Leu Gln Lys His Pro Asn Phe Ala Phe Ser Val Ser Ser 
145                 150                 155                 160 


Val Asn Ser Leu Ser Asn Thr Ile Phe Leu Gly Glu Leu Ser Leu Ile 
                165                 170                 175     


Leu Asn Gln Gly Glu Cys Ser Ser Pro Asp Ile Gln Asn Ser Val Glu 
            180                 185                 190         


Glu Glu Thr Thr Met Leu Leu Glu Asn Asp Ser Pro Ser Glu Thr Ile 
        195                 200                 205             


Pro Glu Gln Thr Leu Leu Pro Asp Glu Phe Val Ser Cys Leu Gly Ile 
    210                 215                 220                 


Val Asn Glu Glu Leu Pro Ser Ile Asn Thr Tyr Phe Pro Gln Asn Ile 
225                 230                 235                 240 


Leu Glu Ser His Phe Asn Arg Ile Ser Leu Leu Glu Lys 
                245                 250             


<210>  67
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  67

Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
1               5                   10                  15      


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            20                  25                  30          


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr 
        35                  40                  45              


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe Pro 
    50                  55                  60                  


Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn Thr 
65                  70                  75                  80  


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                85                  90                  95      


Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn Thr 
            100                 105                 110         


Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His 
        115                 120                 125             


Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln Pro 
    130                 135                 140                 


Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp His 
145                 150                 155                 160 


Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln 
                165                 170                 175     


Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu Arg 
            180                 185                 190         


Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu Lys 
        195                 200                 205             


Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln Met 
    210                 215                 220                 


Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly Thr 
225                 230                 235                 240 


Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala Thr 
                245                 250                 255     


Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln Gly 
            260                 265                 270         


Gly Tyr Met Pro Gln 
        275         


<210>  68
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  68

Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
1               5                   10                  15      


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
            20                  25                  30          


Glu Asn Cys Ser His His Leu 
        35                  


<210>  69
<211>  1515
<212>  DNA
<213>  Homo sapiens

<400>  69
atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc       60

gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac      120

aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg      180

atccctgtgg ggcccatcca gtggttcaga ggagctggac caggccggga attaatctac      240

aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac      300

aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac      360

tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact      420

gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc      480

acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc      540

accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc      600

gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag      660

gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt      720

cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa      780

cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc      840

cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca      900

accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta      960

tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg     1020

gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc     1080

gccgctgaga acactggatc taatgaacgg aacatctata ttgtggtggg tgtggtgtgc     1140

accttgctgg tggccctact gatggcggcc ctctacctcg tccgaatcag acagaagaaa     1200

gcccagggct ccacttcttc tacaaggttg catgagcccg agaagaatgc cagagaaata     1260

acacaggaca caaatgatat cacatatgca gacctgaacc tgcccaaggg gaagaagcct     1320

gctccccagg ctgcggagcc caacaaccac acggagtatg ccagcattca gaccagcccg     1380

cagcccgcgt cggaggacac cctcacctat gctgacctgg acatggtcca cctcaaccgg     1440

acccccaagc agccggcccc caagcctgag ccgtccttct cagagtacgc cagcgtccag     1500

gtcccgagga agtga                                                      1515


<210>  70
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  71
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  71
atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc       60

gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac      120

aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg      180

atccctgtgg ggcccatcca gtggttcaga ggagctggac caggccggga attaatctac      240

aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac      300

aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac      360

tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact      420

gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc      480

acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc      540

accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc      600

gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag      660

gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt      720

cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa      780

cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc      840

cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca      900

accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta      960

tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg     1020

gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc     1080

gccgctgaga acactggatc taatgaacgg aacatctata ttgtggtggg tgtggtgtgc     1140

accttgctgg tggccctact gatggcggcc ctctacctct ga                        1182


<210>  72
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  72

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val 
385                 390                 


<210>  73
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  73
atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc       60

gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac      120

aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg      180

atccctgtgg ggcccatcca gtggttcaga ggagctggac caggccggga attaatctac      240

aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac      300

aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac      360

tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact      420

gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc      480

acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc      540

accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc      600

gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag      660

gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt      720

cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa      780

cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc      840

cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca      900

accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta      960

tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg     1020

gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc     1080

gccgctgaga acactggatc taatgaacgg aacatctata ttgtggtggg tgtggtgtgc     1140

accttgctgg tggccctact gatggcggcc ctctacctcg tccgaatcag acagaagaaa     1200

gcccagggct ccacttcttc tacaaggttg catgagcccg agaagaatgc cagagaaata     1260

acacaggaca caaatgatat cacatttgca gacctgaacc tgcccaaggg gaagaagcct     1320

gctccccagg ctgcggagcc caacaaccac acggagtatg ccagcattca gaccagcccg     1380

cagcccgcgt cggaggacac cctcacctat gctgacctgg acatggtcca cctcaaccgg     1440

acccccaagc agccggcccc caagcctgag ccgtccttct cagagtacgc cagcgtccag     1500

gtcccgagga agtga                                                      1515


<210>  74
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  74

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Phe Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  75
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
1               5                   10                  15      


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
            20                  25                  30          


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
        35                  40                  45              


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
    50                  55                  60                  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
                85                  90                  95      


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
            100                 105                 110         


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
        115                 120                 125             


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
    130                 135                 140                 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
                165                 170                 175     


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
            180                 185                 190         


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
        195                 200                 205             


Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
    210                 215                 220                 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
225                 230                 235                 240 


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
385                 390                 395                 400 


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
        515                 520                 525             


Ser Thr Ala Phe Ser Asn Thr Ala Ala 
    530                 535         


<210>  76
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  76

Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
1               5                   10                  15      


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
            20                  25                  30          


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
        35                  40                  45              


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
    50                  55                  60                  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
                85                  90                  95      


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
            100                 105                 110         


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
        115                 120                 125             


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
    130                 135                 140                 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
                165                 170                 175     


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
            180                 185                 190         


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
        195                 200                 205             


Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
    210                 215                 220                 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
225                 230                 235                 240 


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
385                 390                 395                 400 


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
        515                 520                 525             


Ser Thr Ala Phe Ser Asn Gly Ala Phe Leu Gly Ile Gly Ile Thr Ala 
    530                 535                 540                 


Leu Leu Thr Ala Ala 
545                 


<210>  77
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  77

Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
1               5                   10                  15      


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
            20                  25                  30          


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
        35                  40                  45              


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
    50                  55                  60                  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
                85                  90                  95      


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
            100                 105                 110         


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
        115                 120                 125             


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
    130                 135                 140                 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
                165                 170                 175     


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
            180                 185                 190         


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
        195                 200                 205             


Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
    210                 215                 220                 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
225                 230                 235                 240 


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
385                 390                 395                 400 


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
        515                 520                 525             


Ser Thr Ala Phe Ser Asn Gly Ala Phe Leu Gly Ile Gly Ile Thr Ala 
    530                 535                 540                 


Leu Leu Phe Leu Cys Leu Thr Ala Ala 
545                 550             


<210>  78
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  78

Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
1               5                   10                  15      


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
            20                  25                  30          


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
        35                  40                  45              


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
    50                  55                  60                  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
                85                  90                  95      


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
            100                 105                 110         


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
        115                 120                 125             


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
    130                 135                 140                 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
                165                 170                 175     


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
            180                 185                 190         


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
        195                 200                 205             


Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
    210                 215                 220                 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
225                 230                 235                 240 


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
385                 390                 395                 400 


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
        515                 520                 525             


Ser Thr Ala Phe Ser Asn Gly Ala Phe Leu Gly Ile Gly Ile Thr Ala 
    530                 535                 540                 


Leu Leu Phe Leu Cys Leu Ala Leu Ile Ile Met Lys Ile Leu Pro Lys 
545                 550                 555                 560 


Arg Thr Ala Ala 
                


<210>  79
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  79

Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
1               5                   10                  15      


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
            20                  25                  30          


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
        35                  40                  45              


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
    50                  55                  60                  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
                85                  90                  95      


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
            100                 105                 110         


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
        115                 120                 125             


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
    130                 135                 140                 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
                165                 170                 175     


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
            180                 185                 190         


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
        195                 200                 205             


Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
    210                 215                 220                 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
225                 230                 235                 240 


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
385                 390                 395                 400 


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
        515                 520                 525             


Ser Thr Ala Phe Ser Asn Gly Ala Phe Leu Gly Ile Gly Ile Thr Ala 
    530                 535                 540                 


Leu Leu Phe Leu Cys Leu Ala Leu Ile Ile Met Leu Tyr Cys Asn His 
545                 550                 555                 560 


Arg Thr Ala Ala 
                


<210>  80
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  80

Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
1               5                   10                  15      


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
            20                  25                  30          


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
        35                  40                  45              


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
    50                  55                  60                  


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp 
65                  70                  


<210>  81
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  81

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                325                 330                 335     


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
            340                 345                 350         


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
        355                 360                 365             


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
    370                 375                 380                 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
385                 390                 395                 400 


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                405                 410                 415     


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
            420                 425                 430         


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
        435                 440                 445             


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
    450                 455                 460                 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
465                 470                 475                 480 


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                485                 490                 495     


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
            500                 505                 510         


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
        515                 520                 525             


Leu Asn Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    530                 535                 540                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Tyr Thr Ser Tyr 
545                 550                 555                 560 


Ile Leu Ala Phe Gln Leu Cys Ile Val Leu Gly Ser Leu Gly Cys Tyr 
                565                 570                 575     


Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
            580                 585                 590         


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
        595                 600                 605             


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
    610                 615                 620                 


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
625                 630                 635                 640 


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
                645                 650                 655     


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
            660                 665                 670         


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
        675                 680                 685             


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
    690                 695                 700                 


Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
705                 710                 715                 720 


<210>  82
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  82

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                165                 170                 175     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys His Gln 
            180                 185                 190         


Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu 
        195                 200                 205             


Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
    210                 215                 220                 


Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
225                 230                 235                 240 


Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
                245                 250                 255     


Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
            260                 265                 270         


Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
        275                 280                 285             


Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
    290                 295                 300                 


Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
305                 310                 315                 320 


Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
                325                 330                 335     


Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
            340                 345                 350         


Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
        355                 360                 365             


Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
    370                 375                 380                 


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
385                 390                 395                 400 


Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
                405                 410                 415     


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
            420                 425                 430         


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
        435                 440                 445             


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
    450                 455                 460                 


Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
465                 470                 475                 480 


Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
                485                 490                 495     


Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
            500                 505                 510         


Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg Asn Leu Pro Val 
        515                 520                 525             


Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn 
    530                 535                 540                 


Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu 
545                 550                 555                 560 


Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr 
                565                 570                 575     


Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr 
            580                 585                 590         


Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn 
        595                 600                 605             


Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys 
    610                 615                 620                 


Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys 
625                 630                 635                 640 


Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu 
                645                 650                 655     


Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn 
            660                 665                 670         


Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp 
        675                 680                 685             


Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg 
    690                 695                 700                 


Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
705                 710                 715                 720 


<210>  83
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  83

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                325                 330                 335     


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
            340                 345                 350         


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
        355                 360                 365             


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
    370                 375                 380                 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
385                 390                 395                 400 


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                405                 410                 415     


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
            420                 425                 430         


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
        435                 440                 445             


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
    450                 455                 460                 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
465                 470                 475                 480 


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                485                 490                 495     


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
            500                 505                 510         


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
        515                 520                 525             


Leu Asn Ala Ser Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Gly Ile 
    530                 535                 540                 


Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys Val Leu 
545                 550                 555                 560 


Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe Thr Lys 
                565                 570                 575     


Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys Lys Glu 
            580                 585                 590         


Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr Ile Ile 
        595                 600                 605             


Ser Leu Asp Phe Gly Ser Asn Asp 
    610                 615     


<210>  84
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  84

Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
1               5                   10                  15      


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
            20                  25                  30          


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
        35                  40                  45              


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
    50                  55                  60                  


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp Glu Ala Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Ala Ala Arg Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser 
                85                  90                  95      


Leu Val Phe Leu Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys 
            100                 105                 110         


Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu 
        115                 120                 125             


Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp 
    130                 135                 140                 


Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr 
145                 150                 155                 160 


Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys 
                165                 170                 175     


Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu 
            180                 185                 190         


Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys 
        195                 200                 205             


Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe 
    210                 215                 220                 


Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val 
225                 230                 235                 240 


Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala 
                245                 250                 255     


Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu 
            260                 265                 270         


Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu 
        275                 280                 285             


Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr 
    290                 295                 300                 


Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
305                 310                 315                 320 


Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val 
                325                 330                 335     


Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr 
            340                 345                 350         


Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu 
        355                 360                 365             


Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys 
    370                 375                 380                 


Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser 
385                 390                 395                 400 


Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly 
                405                 410                 415     


Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            420                 425                 430         


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        435                 440                 445             


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    450                 455                 460                 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
465                 470                 475                 480 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                485                 490                 495     


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            500                 505                 510         


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        515                 520                 525             


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    530                 535                 540                 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
545                 550                 555                 560 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                565                 570                 575     


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            580                 585                 590         


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        595                 600                 605             


Val Met Ser Tyr Leu Asn Ala Ser 
    610                 615     


<210>  85
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  85

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg 
                165                 170                 175     


Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
            180                 185                 190         


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
        195                 200                 205             


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
    210                 215                 220                 


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
225                 230                 235                 240 


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp 
                245                 250 


<210>  86
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  86

Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
1               5                   10                  15      


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
            20                  25                  30          


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
        35                  40                  45              


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
    50                  55                  60                  


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp Glu Ala Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Ala Ala Arg Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu 
                85                  90                  95      


Cys Ile Val Leu Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val 
            100                 105                 110         


Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp 
        115                 120                 125             


Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys 
    130                 135                 140                 


Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr 
145                 150                 155                 160 


Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser 
                165                 170                 175     


Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn 
            180                 185                 190         


Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr 
        195                 200                 205             


Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met 
    210                 215                 220                 


Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln 
225                 230                 235                 240 


Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
                245                 250 


<210>  87
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  87

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Gly Ile 
    210                 215                 220                 


Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys Val Leu 
225                 230                 235                 240 


Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe Thr Lys 
                245                 250                 255     


Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys Lys Glu 
            260                 265                 270         


Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr Ile Ile 
        275                 280                 285             


Ser Leu Asp Phe Gly Ser Asn Asp 
    290                 295     


<210>  88
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  88

Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
1               5                   10                  15      


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
            20                  25                  30          


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
        35                  40                  45              


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
    50                  55                  60                  


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp Glu Ala Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Ala Ala Arg Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val 
                85                  90                  95      


Ala Phe Ser Leu Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala 
            100                 105                 110         


Pro Val Pro Pro Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg 
        115                 120                 125             


Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile 
    130                 135                 140                 


Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn 
145                 150                 155                 160 


Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu 
                165                 170                 175     


Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu 
            180                 185                 190         


Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val 
        195                 200                 205             


Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala 
    210                 215                 220                 


Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys 
225                 230                 235                 240 


Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn 
                245                 250                 255     


Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp 
            260                 265                 270         


Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser 
        275                 280                 285             


Ser Leu Arg Ala Leu Arg Gln Met 
    290                 295     


<210>  89
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  89

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    210                 215                 220                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Tyr Thr Ser Tyr 
225                 230                 235                 240 


Ile Leu Ala Phe Gln Leu Cys Ile Val Leu Gly Ser Leu Gly Cys Tyr 
                245                 250                 255     


Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
            260                 265                 270         


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
        275                 280                 285             


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
    290                 295                 300                 


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
305                 310                 315                 320 


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
                325                 330                 335     


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
            340                 345                 350         


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
        355                 360                 365             


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
    370                 375                 380                 


Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
385                 390                 395                 400 


<210>  90
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  90

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                165                 170                 175     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asn Ser Phe 
            180                 185                 190         


Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu Gly Leu Leu Leu 
        195                 200                 205             


Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro Gly Glu Asp Ser 
    210                 215                 220                 


Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu Arg 
225                 230                 235                 240 


Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg 
                245                 250                 255     


Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser Ser Lys Glu Ala 
            260                 265                 270         


Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Lys Asp Gly 
        275                 280                 285             


Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu Val Lys Ile Ile 
    290                 295                 300                 


Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg 
305                 310                 315                 320 


Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln Met Ser Thr Lys 
                325                 330                 335     


Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile 
            340                 345                 350         


Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln 
        355                 360                 365             


Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg 
    370                 375                 380                 


Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met 
385                 390                 395                 400 


<210>  91
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  91

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                325                 330                 335     


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
            340                 345                 350         


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
        355                 360                 365             


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
    370                 375                 380                 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
385                 390                 395                 400 


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                405                 410                 415     


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
            420                 425                 430         


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
        435                 440                 445             


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
    450                 455                 460                 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
465                 470                 475                 480 


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                485                 490                 495     


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
            500                 505                 510         


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
        515                 520                 525             


Leu Asn Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    530                 535                 540                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Tyr Thr Ser Tyr 
545                 550                 555                 560 


Ile Leu Ala Phe Gln Leu Cys Ile Val Leu Gly Ser Leu Gly Cys Tyr 
                565                 570                 575     


Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
            580                 585                 590         


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
        595                 600                 605             


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
    610                 615                 620                 


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
625                 630                 635                 640 


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Ala Tyr Asp Met Asn Val 
                645                 650                 655     


Lys Phe Phe Arg Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
            660                 665                 670         


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
        675                 680                 685             


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
    690                 695                 700                 


Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
705                 710                 715                 720 


<210>  92
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  92

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Ala Tyr Asp Met Asn Val Lys Phe Phe Arg Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                165                 170                 175     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys His Gln 
            180                 185                 190         


Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu 
        195                 200                 205             


Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
    210                 215                 220                 


Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
225                 230                 235                 240 


Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
                245                 250                 255     


Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
            260                 265                 270         


Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
        275                 280                 285             


Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
    290                 295                 300                 


Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
305                 310                 315                 320 


Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
                325                 330                 335     


Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
            340                 345                 350         


Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
        355                 360                 365             


Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
    370                 375                 380                 


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
385                 390                 395                 400 


Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
                405                 410                 415     


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
            420                 425                 430         


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
        435                 440                 445             


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
    450                 455                 460                 


Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
465                 470                 475                 480 


Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
                485                 490                 495     


Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
            500                 505                 510         


Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg Asn Leu Pro Val 
        515                 520                 525             


Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn 
    530                 535                 540                 


Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu 
545                 550                 555                 560 


Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr 
                565                 570                 575     


Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr 
            580                 585                 590         


Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn 
        595                 600                 605             


Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys 
    610                 615                 620                 


Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys 
625                 630                 635                 640 


Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu 
                645                 650                 655     


Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn 
            660                 665                 670         


Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp 
        675                 680                 685             


Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg 
    690                 695                 700                 


Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
705                 710                 715                 720 


<210>  93
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  93

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Ala Tyr Asp Met Asn Val Lys Phe Phe Arg Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg 
                165                 170                 175     


Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
            180                 185                 190         


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
        195                 200                 205             


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
    210                 215                 220                 


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
225                 230                 235                 240 


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp 
                245                 250 


<210>  94
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  94

Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
1               5                   10                  15      


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
            20                  25                  30          


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
        35                  40                  45              


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
    50                  55                  60                  


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp Glu Ala Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Ala Ala Arg Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu 
                85                  90                  95      


Cys Ile Val Leu Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val 
            100                 105                 110         


Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp 
        115                 120                 125             


Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys 
    130                 135                 140                 


Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr 
145                 150                 155                 160 


Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser 
                165                 170                 175     


Val Glu Thr Ile Ala Tyr Asp Met Asn Val Lys Phe Phe Arg Ser Asn 
            180                 185                 190         


Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr 
        195                 200                 205             


Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met 
    210                 215                 220                 


Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln 
225                 230                 235                 240 


Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
                245                 250 


<210>  95
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  95

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu Glu Ala Ala Ala Arg Glu Ala 
225                 230                 235                 240 


Ala Ala Arg Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln 
                245                 250                 255     


Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr 
            260                 265                 270         


Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp 
        275                 280                 285             


Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala 
    290                 295                 300                 


Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp 
305                 310                 315         


<210>  96
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  96

Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
1               5                   10                  15      


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
            20                  25                  30          


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
        35                  40                  45              


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
    50                  55                  60                  


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp Glu Ala Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Ala Ala Arg Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu 
                85                  90                  95      


Ala Glu Glu Ala Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg 
            100                 105                 110         


Arg Cys Leu Phe Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala 
        115                 120                 125             


Thr Thr Leu Phe Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg 
    130                 135                 140                 


Glu Glu Phe Pro Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala 
145                 150                 155                 160 


Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
                165                 170                 175     


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
            180                 185                 190         


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
        195                 200                 205             


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    210                 215                 220                 


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
225                 230                 235                 240 


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                245                 250                 255     


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            260                 265                 270         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        275                 280                 285             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
    290                 295                 300                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
305                 310                 315         


<210>  97
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  97

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                325                 330                 335     


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
            340                 345                 350         


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
        355                 360                 365             


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
    370                 375                 380                 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
385                 390                 395                 400 


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                405                 410                 415     


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
            420                 425                 430         


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
        435                 440                 445             


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
    450                 455                 460                 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
465                 470                 475                 480 


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                485                 490                 495     


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
            500                 505                 510         


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
        515                 520                 525             


Leu Asn Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    530                 535                 540                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asn Ser Phe Ser Thr 
545                 550                 555                 560 


Ser Ala Phe Gly Pro Val Ala Phe Ser Leu Gly Leu Leu Leu Val Leu 
                565                 570                 575     


Pro Ala Ala Phe Pro Ala Pro Val Pro Pro Gly Glu Asp Ser Lys Asp 
            580                 585                 590         


Val Ala Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp 
        595                 600                 605             


Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu 
    610                 615                 620                 


Thr Cys Asn Lys Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala 
625                 630                 635                 640 


Glu Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe 
                645                 650                 655     


Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly 
            660                 665                 670         


Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu 
        675                 680                 685             


Ser Ser Glu Glu Gln Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu 
    690                 695                 700                 


Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr 
705                 710                 715                 720 


Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln 
                725                 730                 735     


Asn Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg Ser Phe 
            740                 745                 750         


Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met 
        755                 760                 765     


<210>  98
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  98

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    210                 215                 220                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys His Gln Gln Leu 
225                 230                 235                 240 


Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val Ala 
                245                 250                 255     


Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
            260                 265                 270         


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
        275                 280                 285             


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
    290                 295                 300                 


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
305                 310                 315                 320 


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
                325                 330                 335     


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
            340                 345                 350         


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
        355                 360                 365             


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
    370                 375                 380                 


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
385                 390                 395                 400 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
                405                 410                 415     


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
            420                 425                 430         


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
        435                 440                 445             


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
    450                 455                 460                 


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
465                 470                 475                 480 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
                485                 490                 495     


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
            500                 505                 510         


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
        515                 520                 525             


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
    530                 535                 540                 


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
545                 550                 555                 560 


Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr 
                565                 570                 575     


Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu 
            580                 585                 590         


Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe 
        595                 600                 605             


Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp 
    610                 615                 620                 


Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn 
625                 630                 635                 640 


Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser 
                645                 650                 655     


Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser 
            660                 665                 670         


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met 
        675                 680                 685             


Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln 
    690                 695                 700                 


Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn 
705                 710                 715                 720 


Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr 
                725                 730                 735     


Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg 
            740                 745                 750         


Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
        755                 760                 765     


<210>  99
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  99

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    210                 215                 220                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Tyr Thr Ser Tyr 
225                 230                 235                 240 


Ile Leu Ala Phe Gln Leu Cys Ile Val Leu Gly Ser Leu Gly Cys Tyr 
                245                 250                 255     


Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
            260                 265                 270         


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
        275                 280                 285             


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
    290                 295                 300                 


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
305                 310                 315                 320 


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Ala Tyr Asp Met Asn Val 
                325                 330                 335     


Lys Phe Phe Arg Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
            340                 345                 350         


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
        355                 360                 365             


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
    370                 375                 380                 


Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
385                 390                 395                 400 


<210>  100
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  100

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Ala Tyr Asp Met Asn Val Lys Phe Phe Arg Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                165                 170                 175     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asn Ser Phe 
            180                 185                 190         


Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu Gly Leu Leu Leu 
        195                 200                 205             


Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro Gly Glu Asp Ser 
    210                 215                 220                 


Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu Arg 
225                 230                 235                 240 


Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg 
                245                 250                 255     


Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser Ser Lys Glu Ala 
            260                 265                 270         


Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Lys Asp Gly 
        275                 280                 285             


Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu Val Lys Ile Ile 
    290                 295                 300                 


Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg 
305                 310                 315                 320 


Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln Met Ser Thr Lys 
                325                 330                 335     


Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile 
            340                 345                 350         


Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln 
        355                 360                 365             


Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg 
    370                 375                 380                 


Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met 
385                 390                 395                 400 


<210>  101
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp 
1               5                   10                  15      


Ala Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu 
            20                  25                  30          


Glu Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu 
        35                  40                  45              


Ile Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys 
    50                  55                  60                  


Ala Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser 
65                  70                  75                  80  


Glu Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln 
                85                  90                  95      


Ser Trp Ile Phe Ser 
            100     


<210>  102
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  102

Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
1               5                   10                  15      


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
            20                  25                  30          


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
        35                  40                  45              


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
    50                  55                  60                  


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp Glu Ala Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Ala Ala Arg Met Pro Lys Lys Lys Ile Gln Leu His Ala Glu His 
                85                  90                  95      


Ala Leu Tyr Asp Ala Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser 
            100                 105                 110         


Pro Pro Ala Glu Glu Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu 
        115                 120                 125             


Ile Leu Glu Glu Ile Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp 
    130                 135                 140                 


Glu Ala Glu Lys Ala Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys 
145                 150                 155                 160 


Thr Thr Ala Ser Glu Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile 
                165                 170                 175     


Thr Ile Leu Gln Ser Trp Ile Phe Ser 
            180                 185 


<210>  103
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  103

Met Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp 
1               5                   10                  15      


Ala Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu 
            20                  25                  30          


Glu Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu 
        35                  40                  45              


Ile Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys 
    50                  55                  60                  


Ala Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser 
65                  70                  75                  80  


Glu Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln 
                85                  90                  95      


Ser Trp Ile Phe Ser Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Gly 
            100                 105                 110         


Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys Val 
        115                 120                 125             


Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe Thr 
    130                 135                 140                 


Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys Lys 
145                 150                 155                 160 


Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr Ile 
                165                 170                 175     


Ile Ser Leu Asp Phe Gly Ser Asn Asp 
            180                 185 


<210>  104
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  104

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  105
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  105

Gly Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys 
1               5                   10                  15      


Val Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe 
            20                  25                  30          


Thr Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys 
        35                  40                  45              


Lys Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr 
    50                  55                  60                  


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp Glu Ala Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Ala Ala Arg Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu 
                85                  90                  95      


Cys Ile Val Leu Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val 
            100                 105                 110         


Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp 
        115                 120                 125             


Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys 
    130                 135                 140                 


Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr 
145                 150                 155                 160 


Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser 
                165                 170                 175     


Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn 
            180                 185                 190         


Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr 
        195                 200                 205             


Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met 
    210                 215                 220                 


Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln 
225                 230                 235                 240 


Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
                245                 250 


<210>  106
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  106

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  107
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  107

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  108
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  108

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  109
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  109

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  110
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  110

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Cys Pro Ser Pro Leu Phe 
            180                 185                 190         


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
        195                 200                 205             


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    210                 215                 220                 


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
225                 230                 235                 240 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                245                 250                 255     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            260                 265     


<210>  111
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  111

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Cys Pro Ser Pro Leu Phe 
            180                 185                 190         


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
        195                 200                 205             


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    210                 215                 220                 


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
225                 230                 235                 240 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                245                 250                 255     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            260                 265     


<210>  112
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  112

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Cys Pro Ser Pro 
                645                 650                 655     


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
            660                 665                 670         


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
        675                 680                 685             


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    690                 695                 700                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
705                 710                 715                 720 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                725                 730         


<210>  113
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  113

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        195                 200                 205             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    210                 215                 220                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
225                 230                 235                 240 


Arg Ser 
        


<210>  114
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  114

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  115
<211>  899
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  115

Met Met Ile Ile Ser Met Trp Met Ser Ile Ser Arg Gly Leu Trp Asp 
1               5                   10                  15      


Ser Ser Ser Ile Trp Ser Val Leu Leu Ile Leu Ala Cys Met Ala Ser 
            20                  25                  30          


Ile Thr Thr Ser Ser Ser Val Ser Asn Ala Gly Tyr Val Asp Asn Gly 
        35                  40                  45              


Asn Met Lys Val Cys Ile Gly Thr Lys Ser Arg Leu Ser Val Pro Ser 
    50                  55                  60                  


Asn Lys Glu His His Tyr Arg Asn Leu Arg Asp Arg Tyr Thr Asn Cys 
65                  70                  75                  80  


Thr Tyr Val Asp Gly Asn Leu Glu Leu Thr Trp Leu Pro Asn Glu Asn 
                85                  90                  95      


Leu Asp Leu Ser Phe Leu Asp Asn Ile Arg Glu Val Thr Gly Tyr Ile 
            100                 105                 110         


Leu Ile Ser His Val Asp Val Lys Lys Val Val Phe Pro Lys Leu Gln 
        115                 120                 125             


Ile Ile Arg Gly Arg Thr Leu Phe Ser Leu Ser Val Glu Glu Glu Lys 
    130                 135                 140                 


Tyr Ala Leu Phe Val Thr Tyr Ser Lys Met Tyr Thr Leu Glu Ile Pro 
145                 150                 155                 160 


Asp Leu Arg Asp Val Leu Asn Gly Gln Val Gly Phe His Asn Asn Tyr 
                165                 170                 175     


Asn Leu Cys His Met Arg Thr Ile Gln Trp Ser Glu Ile Val Ser Asn 
            180                 185                 190         


Gly Thr Asp Ala Tyr Tyr Asn Tyr Asp Phe Thr Ala Pro Glu Arg Glu 
        195                 200                 205             


Cys Pro Lys Cys His Glu Ser Cys Thr His Gly Cys Trp Gly Glu Gly 
    210                 215                 220                 


Pro Lys Asn Cys Gln Lys Phe Ser Lys Leu Thr Cys Ser Pro Gln Cys 
225                 230                 235                 240 


Ala Gly Gly Arg Cys Tyr Gly Pro Lys Pro Arg Glu Cys Cys His Leu 
                245                 250                 255     


Phe Cys Ala Gly Gly Cys Thr Gly Pro Thr Gln Lys Asp Cys Ile Ala 
            260                 265                 270         


Cys Lys Asn Phe Phe Asp Glu Gly Val Cys Lys Glu Glu Cys Pro Pro 
        275                 280                 285             


Met Arg Lys Tyr Asn Pro Thr Thr Tyr Val Leu Glu Thr Asn Pro Glu 
    290                 295                 300                 


Gly Lys Tyr Ala Tyr Gly Ala Thr Cys Val Lys Glu Cys Pro Gly His 
305                 310                 315                 320 


Leu Leu Arg Asp Asn Gly Ala Cys Val Arg Ser Cys Pro Gln Asp Lys 
                325                 330                 335     


Met Asp Lys Gly Gly Glu Cys Val Pro Cys Asn Gly Pro Cys Pro Lys 
            340                 345                 350         


Thr Cys Pro Gly Val Thr Val Leu His Ala Gly Asn Ile Asp Ser Phe 
        355                 360                 365             


Arg Asn Cys Thr Val Ile Asp Gly Asn Ile Arg Ile Leu Asp Gln Thr 
    370                 375                 380                 


Phe Ser Gly Phe Gln Asp Val Tyr Ala Asn Tyr Thr Met Gly Pro Arg 
385                 390                 395                 400 


Tyr Ile Pro Leu Asp Pro Glu Arg Leu Glu Val Phe Ser Thr Val Lys 
                405                 410                 415     


Glu Ile Thr Gly Tyr Leu Asn Ile Glu Gly Thr His Pro Gln Phe Arg 
            420                 425                 430         


Asn Leu Ser Tyr Phe Arg Asn Leu Glu Thr Ile His Gly Arg Gln Leu 
        435                 440                 445             


Met Glu Ser Met Phe Ala Ala Leu Ala Ile Val Lys Ser Ser Leu Tyr 
    450                 455                 460                 


Ser Leu Glu Met Arg Asn Leu Lys Gln Ile Ser Ser Gly Ser Val Val 
465                 470                 475                 480 


Ile Gln His Asn Arg Asp Leu Cys Tyr Val Ser Asn Ile Arg Trp Pro 
                485                 490                 495     


Ala Ile Gln Lys Glu Pro Glu Gln Lys Val Trp Val Asn Glu Asn Leu 
            500                 505                 510         


Arg Ala Asp Leu Cys Glu Lys Asn Gly Thr Ile Cys Ser Asp Gln Cys 
        515                 520                 525             


Asn Glu Asp Gly Cys Trp Gly Ala Gly Thr Asp Gln Cys Leu Thr Cys 
    530                 535                 540                 


Lys Asn Phe Asn Phe Asn Gly Thr Cys Ile Ala Asp Cys Gly Tyr Ile 
545                 550                 555                 560 


Ser Asn Ala Tyr Lys Phe Asp Asn Arg Thr Cys Lys Ile Cys His Pro 
                565                 570                 575     


Glu Cys Arg Thr Cys Asn Gly Ala Gly Ala Asp His Cys Gln Glu Cys 
            580                 585                 590         


Val His Val Arg Asp Gly Gln His Cys Val Ser Glu Cys Pro Lys Asn 
        595                 600                 605             


Lys Tyr Asn Asp Arg Gly Val Cys Arg Glu Cys His Ala Thr Cys Asp 
    610                 615                 620                 


Gly Cys Thr Gly Pro Lys Asp Thr Ile Gly Ile Gly Ala Cys Thr Thr 
625                 630                 635                 640 


Cys Asn Leu Ala Ile Ile Asn Asn Asp Ala Thr Val Lys Arg Cys Leu 
                645                 650                 655     


Leu Lys Asp Asp Lys Cys Pro Asp Gly Tyr Phe Trp Glu Tyr Val His 
            660                 665                 670         


Pro Gln Glu Gln Gly Ser Leu Lys Pro Leu Ala Gly Arg Ala Val Cys 
        675                 680                 685             


Arg Lys Cys His Pro Leu Cys Glu Leu Cys Thr Asn Tyr Gly Tyr His 
    690                 695                 700                 


Glu Gln Val Cys Ser Lys Cys Thr His Tyr Lys Arg Arg Glu Gln Cys 
705                 710                 715                 720 


Glu Thr Glu Cys Pro Ala Asp His Tyr Thr Asp Glu Glu Gln Arg Glu 
                725                 730                 735     


Cys Phe Gln Cys His Pro Glu Cys Asn Gly Cys Thr Gly Pro Gly Ala 
            740                 745                 750         


Asp Asp Cys Lys Ser Cys Arg Asn Phe Lys Leu Phe Asp Ala Asn Glu 
        755                 760                 765             


Thr Gly Pro Tyr Val Asn Ser Thr Met Phe Asn Cys Thr Ser Lys Cys 
    770                 775                 780                 


Pro Leu Glu Met Arg His Val Asn Tyr Gln Tyr Thr Ala Ile Gly Pro 
785                 790                 795                 800 


Tyr Cys Ala Ala Ser Pro Pro Arg Ser Ser Lys Ile Thr Ala Asn Leu 
                805                 810                 815     


Asp Val Asn Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
            820                 825                 830         


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        835                 840                 845             


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
    850                 855                 860                 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
865                 870                 875                 880 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                885                 890                 895     


Tyr Arg Ser 
            


<210>  116
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  116

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Cys 
            180                 185                 190         


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
        195                 200                 205             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    210                 215                 220                 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
225                 230                 235                 240 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                245                 250                 255     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            260                 265                 270     


<210>  117
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  117

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Asp Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Phe Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
        115                 120                 125             


Gly Gly Glu Val Met Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys 
    130                 135                 140                 


Ala Thr Gly Tyr Thr Phe Thr Gly Tyr Trp Ile Glu Trp Ile Lys Gln 
145                 150                 155                 160 


Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser 
                165                 170                 175     


Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr 
            180                 185                 190         


Ala His Thr Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Thr Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg Asp Ser Asn Ser Phe 
    210                 215                 220                 


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr 
225                 230                 235                 240 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
                245                 250                 255     


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
            260                 265                 270         


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
        275                 280                 285             


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
    290                 295                 300                 


Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
305                 310                 315                 320 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                325                 330                 335     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            340                 345                 350         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        355                 360                 365             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    370                 375                 380                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
385                 390                 395                 400 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                405                 410                 415     


Pro Arg 
        


<210>  118
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  118

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Gly Val Tyr Asp Gly Arg Glu His Thr Val Gly Cys 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg 
        35                  40                  45              


Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys 
    50                  55                  60                  


Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile 
65                  70                  75                  80  


Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His 
                85                  90                  95      


Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr 
            100                 105                 110         


Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn 
        115                 120                 125             


His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
                165                 170                 175     


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
            180                 185                 190         


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
        195                 200                 205             


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
    210                 215                 220                 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
225                 230                 235                 240 


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
                245                 250                 255     


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
            260                 265                 270         


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
        275                 280                 285             


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala 
    290                 295                 300                 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
305                 310                 315                 320 


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
                325                 330                 335     


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
            340                 345                 350         


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
        355                 360                 365             


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
    370                 375                 380                 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
385                 390                 395                 400 


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
                405                 410                 415     


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
            420                 425                 430         


Pro Leu Thr Leu Arg Trp Glu Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        435                 440                 445             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    450                 455                 460                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
465                 470                 475                 480 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                485                 490                 495     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
            500                 505                 510         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        515                 520                 525             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    530                 535                 540                 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
545                 550                 555                 560 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                565                 570                 575     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            580                 585                 590         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        595                 600                 605             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    610                 615                 620                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
625                 630                 635                 640 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                645                 650                 655     


Gln Ala Leu Pro Pro Arg 
            660         


<210>  119
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  119

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Gly Val Tyr Asp Gly Arg Glu His Thr Val Gly Cys 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg 
        35                  40                  45              


Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys 
    50                  55                  60                  


Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile 
65                  70                  75                  80  


Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His 
                85                  90                  95      


Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr 
            100                 105                 110         


Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn 
        115                 120                 125             


His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
                165                 170                 175     


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
            180                 185                 190         


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
        195                 200                 205             


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
    210                 215                 220                 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
225                 230                 235                 240 


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
                245                 250                 255     


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
            260                 265                 270         


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
        275                 280                 285             


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala 
    290                 295                 300                 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
305                 310                 315                 320 


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
                325                 330                 335     


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
            340                 345                 350         


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
        355                 360                 365             


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
    370                 375                 380                 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
385                 390                 395                 400 


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
                405                 410                 415     


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
            420                 425                 430         


Pro Leu Thr Leu Arg Trp Glu Glu Pro Lys Ser Cys Asp Lys Thr His 
        435                 440                 445             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    450                 455                 460                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
465                 470                 475                 480 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                485                 490                 495     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            500                 505                 510         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        515                 520                 525             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    530                 535                 540                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
545                 550                 555                 560 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                565                 570                 575     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
            580                 585                 590         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        595                 600                 605             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    610                 615                 620                 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
625                 630                 635                 640 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                645                 650                 655     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665                 670     


<210>  120
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Gln Ala Arg Gly Tyr Thr Ser Asp His Asn Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Pro Ser Tyr Tyr Val Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Thr Ser Ser Gln Ser Leu Phe Asn 
145                 150                 155                 160 


Val Arg Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Lys 
    210                 215                 220                 


Gln Ser Tyr Asp Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  121
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Gln Ala Arg Gly Tyr Thr Ser Asp His Asn Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Pro Ser Tyr Tyr Val Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Thr Ser Ser Gln Ser Leu Phe Asn 
145                 150                 155                 160 


Val Arg Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Lys 
    210                 215                 220                 


Gln Ser Tyr Asp Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Val Tyr Asp Gly Arg Glu His Thr Val Gly 
            260                 265                 270         


Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln 
        275                 280                 285             


Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly 
    290                 295                 300                 


Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp 
305                 310                 315                 320 


Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu 
                325                 330                 335     


His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr 
            340                 345                 350         


Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val 
        355                 360                 365             


Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp 
    370                 375                 380                 


Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser 
                405                 410                 415     


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr 
            420                 425                 430         


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln 
        435                 440                 445             


Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr 
    450                 455                 460                 


Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg 
465                 470                 475                 480 


Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly 
                485                 490                 495     


Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp 
            500                 505                 510         


Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr 
        515                 520                 525             


Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala 
    530                 535                 540                 


Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln 
545                 550                 555                 560 


Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr 
                565                 570                 575     


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr 
            580                 585                 590         


His Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys 
        595                 600                 605             


Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
    610                 615                 620                 


Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
625                 630                 635                 640 


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
                645                 650                 655     


Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
            660                 665                 670         


Lys Pro Leu Thr Leu Arg Trp Glu His His His His His His 
        675                 680                 685     


<210>  122
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  122

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Met Leu Tyr Gln His Leu Leu Pro Leu Gly Cys Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp 
    210                 215                 220                 


Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp 
225                 230                 235                 240 


Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His 
                245                 250                 255     


Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe 
            260                 265                 270         


Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala 
        275                 280                 285             


Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln 
    290                 295                 300                 


Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met 
            340                 345                 350         


Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro 
            420                 425                 430         


Leu Thr Leu Arg Trp Glu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        435                 440                 445             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    450                 455                 460                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
465                 470                 475                 480 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                485                 490                 495     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
            500                 505                 510         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        515                 520                 525             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    530                 535                 540                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
545                 550                 555                 560 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                565                 570                 575     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            580                 585                 590         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        595                 600                 605             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    610                 615                 620                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
625                 630                 635                 640 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                645                 650                 655     


Ala Leu Pro Pro Arg 
            660     


<210>  123
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  123

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Met Leu Tyr Gln His Leu Leu Pro Leu Gly Cys Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser 
                165                 170                 175     


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp 
            180                 185                 190         


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met 
        195                 200                 205             


Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp 
    210                 215                 220                 


Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp 
225                 230                 235                 240 


Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His 
                245                 250                 255     


Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe 
            260                 265                 270         


Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala 
        275                 280                 285             


Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln 
    290                 295                 300                 


Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg 
305                 310                 315                 320 


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu 
                325                 330                 335     


Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met 
            340                 345                 350         


Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala 
        355                 360                 365             


Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly 
    370                 375                 380                 


Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly 
385                 390                 395                 400 


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln 
                405                 410                 415     


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro 
            420                 425                 430         


Leu Thr Leu Arg Trp Glu Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        435                 440                 445             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    450                 455                 460                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
465                 470                 475                 480 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                485                 490                 495     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            500                 505                 510         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        515                 520                 525             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    530                 535                 540                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
545                 550                 555                 560 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                565                 570                 575     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
            580                 585                 590         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        595                 600                 605             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    610                 615                 620                 


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
625                 630                 635                 640 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                645                 650                 655     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665                 670 


<210>  124
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Gln Ala Arg Gly Tyr Thr Ser Asp His Asn Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Pro Ser Tyr Tyr Val Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Thr Ser Ser Gln Ser Leu Phe Asn 
145                 150                 155                 160 


Val Arg Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Lys 
    210                 215                 220                 


Gln Ser Tyr Asp Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  125
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  125

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Gln Ala Arg Gly Tyr Thr Ser Asp His Asn Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Pro Ser Tyr Tyr Val Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Thr Ser Ser Gln Ser Leu Phe Asn 
145                 150                 155                 160 


Val Arg Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Lys 
    210                 215                 220                 


Gln Ser Tyr Asp Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Met Leu Tyr Gln His Leu Leu Pro Leu Gly Cys 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg 
        275                 280                 285             


Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys 
    290                 295                 300                 


Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile 
305                 310                 315                 320 


Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His 
                325                 330                 335     


Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr 
            340                 345                 350         


Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn 
        355                 360                 365             


His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
                405                 410                 415     


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
            420                 425                 430         


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
        435                 440                 445             


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
    450                 455                 460                 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
465                 470                 475                 480 


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
                485                 490                 495     


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
            500                 505                 510         


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
        515                 520                 525             


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala 
    530                 535                 540                 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
545                 550                 555                 560 


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
                565                 570                 575     


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
            580                 585                 590         


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
        595                 600                 605             


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
    610                 615                 620                 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
625                 630                 635                 640 


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
                645                 650                 655     


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
            660                 665                 670         


Pro Leu Thr Leu Arg Trp Glu His His His His His His 
        675                 680                 685 


<210>  126
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Leu Tyr Gln His Leu Leu Pro Leu Gly Cys Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
        115                 120             


<210>  127
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Gln Ala Arg Gly Tyr Thr Ser Asp His Asn Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Pro Ser Tyr Tyr Val Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  128
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  128

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
    130                 135                 140                 


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
145                 150                 155                 160 


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
                165                 170                 175     


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe 
            180                 185                 190         


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
        195                 200                 205             


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Leu Gly Phe Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln 
            260                 265                 270         


Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        275                 280                 285             


Cys Arg Ala Ser Gln Ser Val Ser Arg Asn Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg 
305                 310                 315                 320 


Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
                325                 330                 335     


Phe Thr Leu Thr Ile Gly Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Tyr Lys Thr Trp Pro Arg Thr Phe Gly Gln Gly Thr 
        355                 360                 365             


Asn Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu 
385                 390                 395                 400 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Phe Gly Gly Ser 
                405                 410                 415     


Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly 
            420                 425                 430         


Leu Glu Trp Ile Gly Glu Ile Asn His Arg Gly Asn Thr Asn Asp Asn 
        435                 440                 445             


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
    450                 455                 460                 


Gln Phe Ala Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Arg Glu Arg Gly Tyr Thr Tyr Gly Asn Phe Asp His 
                485                 490                 495     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505         


<210>  129
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  129

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Lys Thr Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Arg 
                165                 170                 175     


Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg Gly Tyr Thr 
    210                 215                 220                 


Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
            260                 265                 270         


Thr Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
        275                 280                 285             


Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
305                 310                 315                 320 


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val 
            340                 345                 350         


Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly 
        355                 360                 365             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
385                 390                 395                 400 


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                405                 410                 415     


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
            420                 425                 430         


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr 
        435                 440                 445             


Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
    450                 455                 460                 


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr 
465                 470                 475                 480 


Ala Thr Tyr Phe Cys Ala Arg Leu Gly Phe Gly Asn Ala Met Asp Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            500                 505         


<210>  130
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  130

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
    130                 135                 140                 


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
145                 150                 155                 160 


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
                165                 170                 175     


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe 
            180                 185                 190         


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
        195                 200                 205             


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Leu Gly Phe Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Ser Val Thr Val Ser Ser 
                245     


<210>  131
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  131

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


