                               SEQUENCE LISTING

<110> LEKHOLM, EMILIA
      FORSBERG, ERICA
      HOSSEINI, KIMIA
      FREDRIKSSON, ROBERT
      DO, ANH-TRI
 
<120> NOVEL X-APTAMERS FOR THE USE IN DETECTION OF SNAP25 

<130> 105153-0310

<140>
<141>

<160> 103   

<170> PatentIn version 3.5

<210> 1
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer SNAP.01 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 1
tttttaacac gacncancng tgggncncga acancgangg agtgggccca tg               52


<210> 2
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer SNAP.02 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 2
tttttaagcc cacacngcng tgaaggacac agcccgacan cgncgngcca tg               52


<210> 3
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer SNAP.03 sequence


<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 3
tttttaagcc cacgggngnn cgacagacac agcaanacan cgtgggccca tg               52


<210> 4
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer SNAP.04 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 4
tttttaagcc cacccaccng tggacancga accncacngc agtgggccca tg               52


<210> 5
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer SNAP.05 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<400> 5
tttttaagcc caccccggnn cgccagacga accccaacag tgtgggccca tg               52


<210> 6
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer SNAP.06 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 6
tttttaagcc cacnncgcng tgagcaacga acancgagca ggncgngcca tg               52


<210> 7
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer SNAP.07 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 7
tttttaacac gaccgggcng tgcacancga acacngcggn cgncgngcca tg               52


<210> 8
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer SNAP.08 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 8
tttttaacac gacngaagnn cgccaggcga acancgtggn ggncgngcca tg               52


<210> 9
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.01 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<400> 9
tttttaacac gacgcgacng tgagaggcac agtnnggggg cgtgggccca tg               52


<210> 10
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.02 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 10
tttttaacac gaccanccng tgccncacga actcantgcc cgncgngcca tg               52


<210> 11
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.03 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<400> 11
tttttaacac gacgggggnn cgggcagcga acagangggc ggtgggccca tg               52


<210> 12
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.04 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 12
tttttaacac gacgcnccng tgacagccga acancatngg tgncgngcca tg               52


<210> 13
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.05 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 13
tttttaagcc caccaagcng tggcgggcac agggcagcan cgncgngcca tg               52


<210> 14
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.06 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 14
tttttaagcc caccncagnn cgcncancga acgacgangc tgtgggccca tg               52


<210> 15
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.07 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 15
tttttaacac gacncaacng tganncccac agacngggcn cgtgggccca tg               52


<210> 16
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.08 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 16
tttttaacac gaccccggnn cgacncccac agagcggggg tgncgngcca tg               52


<210> 17
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.09 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (23)..(23)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<400> 17
tttttaacac gacnnancng tgncagncga acgncgcgga ggtgggccca tg               52


<210> 18
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.10 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 18
tttttaacac gacgggcgnn cgcnggncga acaccaangc tgtgggccca tg               52


<210> 19
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.11 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 19
tttttaacac gacgccagnn cgaaggncac agtnantngg cgncgngcca tg               52


<210> 20
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.12 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 20
tttttaagcc cacaaaagnn cgancagcac aggncgccaa agncgngcca tg               52


<210> 21
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.13 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (23)..(23)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 21
tttttaagcc caccaaccng tgncncgcga acganggngc cgtgggccca tg               52


<210> 22
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.14 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 22
tttttaagcc caccngacng tggngggcac agtncgccan cgtgggccca tg               52


<210> 23
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.15 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<400> 23
tttttaagcc caccncncng tgggagacac agtnantgca ggtgggccca tg               52


<210> 24
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.16 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 24
tttttaacac gacgggccng tgaacaccga actgangggn cgtgggccca tg               52


<210> 25
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.17 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 25
tttttaacac gacggcggnn cgccncccga acgnngtngg agncgngcca tg               52


<210> 26
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.18 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<400> 26
tttttaacac gaccacccng tgcaaggcga actccgtcaa agtgggccca tg               52


<210> 27
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.19 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 27
tttttaacac gacanagcng tgacaggcac aggncatggg agncgngcca tg               52


<210> 28
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.20 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<400> 28
tttttaacac gacgaaccng tgcncaacac agaacatcac agtgggccca tg               52


<210> 29
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.21 sequence


<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<400> 29
tttttaagcc caccggncng tggnncccac agtgcatgcg agtgggccca tg               52


<210> 30
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.22 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<400> 30
tttttaacac gacnngggnn cggaaggcga accgcagcaa tgtgggccca tg               52


<210> 31
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.23 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 31
tttttaagcc cacnncacng tggcncgcac aggccgangg ggncgngcca tg               52


<210> 32
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 1.24 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 32
tttttaacac gaccgcccng tgggcaacac agggancngc agncgngcca tg               52


<210> 33
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.01 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 33
tttttaacac gacgnnacng tggncaccac aggangagcc tgncgngcca tg               52


<210> 34
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.02 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 34
tttttaagcc cacanacgnn cganggncac aganngggca agncgngcca tg               52


<210> 35
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.03 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 35
tttttaacac gacggngcng tgcnggncac agcacgcgcg cgncgngcca tg               52


<210> 36
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.04 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 36
tttttaacac gacanggcng tggncancac agcgcaccan tgncgngcca tg               52


<210> 37
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.05 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 37
tttttaagcc cacccnacng tggncaccac agtgcaagcc cgncgngcca tg               52


<210> 38
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.06 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 38
tttttaacac gaccggccng tggncagcac agacngtngn ggncgngcca tg               52


<210> 39
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.07 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 39
tttttaacac gacgncgcng tggncaacga acaganacaa cgncgngcca tg               52


<210> 40
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.08 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 40
tttttaagcc cacgnnngnn cggnggncac agcacgccac ggncgngcca tg               52


<210> 41
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.09 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 41
tttttaacac gacanaggnn cgcnggncac agaangtngn ggtgggccca tg               52


<210> 42
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.10 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 42
tttttaagcc cacnggccng tggncagcga actgngcgcn ggtgggccca tg               52


<210> 43
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.11 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<400> 43
tttttaagcc cacnnggcng tgcacancac agaacaagca ggtgggccca tg               52


<210> 44
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.12 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (23)..(23)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 44
tttttaacac gacnagacng tgnancccac agggcaangn ggncgngcca tg               52


<210> 45
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.13 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 45
tttttaagcc cacangccng tggncancga acanngggcc ggncgngcca tg               52


<210> 46
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.14 sequence


<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<400> 46
tttttaagcc cacgggncng tggncaccga acgacgtggc agtgggccca tg               52


<210> 47
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.15 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 47
tttttaacac gacgnnacng tggncaccac aggangagcn tgncgngcca tg               52


<210> 48
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.16 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 48
tttttaagcc cacanaggnn cggnggncac agtgnggngc ggtgggccca tg               52


<210> 49
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.17 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 49
tttttaacac gacgnnacng tggncaccac aggangaggc tgncgngcca tg               52


<210> 50
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 2.18 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 50
tttttaacac gacgnnacng tggncancac aggangagcc tgncgngcca tg               52


<210> 51
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.01 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 51
tttttaacac gacaccacng tggnncncac agcnangngn tgtgggccca tg               52


<210> 52
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.02 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 52
tttttaacac gacagcacng tggnncgcga accncaagcn cgncgngcca tg               52


<210> 53
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.03 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 53
tttttaacac gacaanggnn cggggggcga acgncacngn ggncgngcca tg               52


<210> 54
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.04 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 54
tttttaagcc cacggcacng tgcncagcac agcncggggn ggtgggccca tg               52


<210> 55
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.05 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (23)..(23)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 55
tttttaacac gacgacacng tgnngggcga actccgcngg ggtgggccca tg               52


<210> 56
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.06 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 56
tttttaacac gaccgcacng tganaggcga acggngtgga ggncgngcca tg               52


<210> 57
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.07 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<400> 57
tttttaagcc cacgacacng tggccaacac agtacatgca tgtgggccca tg               52


<210> 58
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.08 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 58
tttttaacac gacgncacng tggnncncga acgccgcgcn tgncgngcca tg               52


<210> 59
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.09 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (23)..(23)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<400> 59
tttttaagcc cacngcacng tgnacancga actgcaccaa cgtgggccca tg               52


<210> 60
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.10 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<400> 60
tttttaacac gacagcacng tgcacagcac agcncaaggg tgtgggccca tg               52


<210> 61
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.11 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 61
tttttaagcc cacngncgnn cggcgggcga acgacagcan ggncgngcca tg               52


<210> 62
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.12 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<400> 62
tttttaacac gacnanccng tgagcaacac agggcggcac tgtgggccca tg               52


<210> 63
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.13 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 63
tttttaacac gacancacng tgcacagcga actgcgtngg cgncgngcca tg               52


<210> 64
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.14 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 64
tttttaacac gacaccacng tgcccaccac agtncacnga agtgggccca tg               52


<210> 65
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.15 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 65
tttttaacac gacngcacng tgaancncga acgcancggg agncgngcca tg               52


<210> 66
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.16 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<400> 66
tttttaagcc cacancacng tgcgagccac agancaggca ggtgggccca tg               52


<210> 67
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.17 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<400> 67
tttttaagcc cacnagagnn cggccancac agtccaacac tgtgggccca tg               52


<210> 68
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.18 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 68
tttttaacac gacacgggnn cgcacancac agaganacac tgncgngcca tg               52


<210> 69
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.19 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 69
tttttaagcc cacgccacng tgaccancga accacacggc cgncgngcca tg               52


<210> 70
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.20 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (23)..(23)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<400> 70
tttttaagcc cacagnncng tgnncancac agagcaacac tgtgggccca tg               52


<210> 71
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.21 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (23)..(23)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 71
tttttaagcc cacnccggnn cgnccancac agcccacngn ggncgngcca tg               52


<210> 72
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.22 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 72
tttttaacac gacancacng tggaagacac aggacgtgcg tgncgngcca tg               52


<210> 73
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.23 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<400> 73
tttttaagcc caccncacng tgcaagncac aggncggcac cgtgggccca tg               52


<210> 74
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 3.24 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 74
tttttaagcc caccagggnn cgggagccga acgccagcac tgncgngcca tg               52


<210> 75
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.01 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 75
tttttaagcc cacaagcgnn cggcncncac agancgtnga cgtgggccca tg               52


<210> 76
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.02 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<400> 76
tttttaagcc cacnacngnn cgaagggcac agtccaggcc ggtgggccca tg               52


<210> 77
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.03 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (23)..(23)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 77
tttttaacac gacaggggnn cgnaggacac aggnngangn tgtgggccca tg               52


<210> 78
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.04 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 78
tttttaagcc cacganccng tgcnncgcac agcncgagcn agtgggccca tg               52


<210> 79
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.05 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 79
tttttaagcc cacanaagnn cgcaagncac agcgangnga tgncgngcca tg               52


<210> 80
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.06 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 80
tttttaagcc cacgagagnn cganagncac agannggcac cgncgngcca tg               52


<210> 81
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.07 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 81
tttttaagcc cacncgngnn cgcacaccga accacaagcn agtgggccca tg               52


<210> 82
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.08 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<400> 82
tttttaacac gaccanncng tgccagccga actccgtgcn ggtgggccca tg               52


<210> 83
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.09 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 83
tttttaacac gacanangnn cgacggacac agtgngtggc ggncgngcca tg               52


<210> 84
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.10 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (40)..(40)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 84
tttttaagcc cacaagacng tgcgncgcac agannggcan cgncgngcca tg               52


<210> 85
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.11 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (23)..(23)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 85
tttttaagcc cacccgagnn cgnccagcga accacgcgcg tgncgngcca tg               52


<210> 86
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.12 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 86
tttttaacac gacagcccng tgcaggccga acggcgtnga tgncgngcca tg               52


<210> 87
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.13 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 87
tttttaagcc cacggccgnn cggccaccac agtgnggcag cgncgngcca tg               52


<210> 88
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.14 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 88
tttttaagcc cacaaaagnn cgggcagcac aggncgcnga ggncgngcca tg               52


<210> 89
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.15 sequence


<220>
<221> modified_base
<222> (15)..(15)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<400> 89
tttttaacac gacgngacng tgagaggcac agtnnggggg cgtgggccca tg               52


<210> 90
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.16 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<400> 90
tttttaacac gacagaccng tganggncga actccatgca tgtgggccca tg               52


<210> 91
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.17 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (24)..(24)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 91
tttttaagcc cacgccagnn cggncaacga actacggnga tgtgggccca tg               52


<210> 92
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.18 sequence


<220>
<221> modified_base
<222> (14)..(14)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<400> 92
tttttaacac gacnanncng tgagncncga actgcgacaa cgtgggccca tg               52


<210> 93
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.19 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (27)..(27)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 93
tttttaagcc cacaagcgnn cggcncncat agancgtnga cgtgggccca tg               52


<210> 94
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.20 sequence


<220>
<221> modified_base
<222> (17)..(17)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (20)..(20)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (25)..(25)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (36)..(36)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 94
tttttaagcc cacacgngnn cggancgcac agtnantggc agncgngcca tg               52


<210> 95
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.21 sequence


<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (34)..(34)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (35)..(35)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (43)..(43)
<223> A modified nucleotide comprising an amine functional group 

<220>
<221> modified_base
<222> (46)..(46)
<223> A modified nucleotide comprising a phenol functional group 

<400> 95
tttttaagcc cacggggcng tgagcaacga acannggcac agncgngcca tg               52


<210> 96
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      X-aptamer PEP 4.22 sequence


<220>
<221> modified_base
<222> (16)..(16)
<223> A modified nucleotide comprising an indol functional group 

<220>
<221> modified_base
<222> (19)..(19)
<223> A modified nucleotide comprising a phenol functional group 

<220>
<221> modified_base
<222> (38)..(38)
<223> A modified nucleotide comprising an indol functional group 

<400> 96
tttttaagcc cacggngcng tggaagccac agtacaangg agtgggccca tg               52


<210> 97
<211> 35
<212> PRT
<213> Homo sapiens

<400> 97
Trp Gly Asn Asn Gln Asp Gly Val Val Ala Ser Gln Pro Ala Arg Val 
1               5                   10                  15      


Val Asp Glu Arg Glu Gln Met Ala Ile Ser Gly Gly Phe Ile Arg Arg 
            20                  25                  30          


Val Thr Asn 
        35  


<210> 98
<211> 37
<212> PRT
<213> Homo sapiens

<400> 98
Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met Leu Gln Leu Val 
1               5                   10                  15      


Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val Met Leu Asp Glu 
            20                  25                  30          


Gln Gly Glu Gln Leu 
        35          


<210> 99
<211> 33
<212> PRT
<213> Homo sapiens

<400> 99
Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys 
1               5                   10                  15      


Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser 
            20                  25                  30          


Gly 
    


<210> 100
<211> 24
<212> PRT
<213> Homo sapiens

<400> 100
Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys 
1               5                   10                  15      


Thr Arg Ile Asp Glu Ala Asn Gln 
            20                  


<210> 101
<211> 225
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      modified human SNAP25 comprising a 5' myc tag and 
      a 3' FLAG tag sequence

<400> 101
Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met Ala Glu Asp Ala 
1               5                   10                  15      


Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg Arg Ala Asp Gln Leu 
            20                  25                  30          


Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met Leu Gln Leu Val Glu 
        35                  40                  45              


Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val Met Leu Asp Glu Gln 
    50                  55                  60                  


Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met Asp Gln Ile Asn Lys 
65                  70                  75                  80  


Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp Leu Gly Lys Phe Cys 
                85                  90                  95      


Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys Ser Ser Asp Ala Tyr 
            100                 105                 110         


Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val Val Ala Ser Gln Pro 
        115                 120                 125             


Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile Ser Gly Gly Phe 
    130                 135                 140                 


Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu Met Asp Glu Asn 
145                 150                 155                 160 


Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala Leu 
                165                 170                 175     


Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg Ile 
            180                 185                 190         


Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala Asn Gln 
        195                 200                 205             


Arg Ala Thr Lys Met Leu Gly Ser Gly Asp Tyr Lys Asp Asp Asp Asp 
    210                 215                 220                 


Lys 
225 


<210> 102
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Sequence N1, a FLAG tag 

<400> 102
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 103
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Sequence N2, a myc tag 

<400> 103
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


