                         SEQUENCE LISTING

<110>  Advanced Accelerator Applications International
       Advanced Accelerator Applications International USA Inc
       Novartis Pharma AG
 
<120>  METHOD OF TREATING PSMA-EXPRESSING CANCERS

<130>  BEP200507

<160>  171   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  1

Thr Tyr Trp Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  2

Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  3

Trp Thr Thr Gly Thr Gly Ala Tyr 
1               5               


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  4

Gly Tyr Thr Phe Thr Thr Tyr 
1               5           


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  5

Tyr Pro Gly Thr Gly Gly 
1               5       


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  6

Trp Thr Thr Gly Thr Gly Ala Tyr 
1               5               


<210>  7
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  7
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaagc ccggcgagtc actgagaatt       60

agctgtaaag gttcaggcta caccttcact acctactgga tgcactgggt ccgccaggct      120

accggtcaag gcctcgagtg gatgggtaat atctaccccg gcaccggcgg ctctaacttc      180

gacgagaagt ttaagaatag agtgactatc accgccgata agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcac taggtggact      300

accggcacag gcgcctactg gggtcaaggc actaccgtga ccgtgtctag c               351


<210>  8
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  8

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Thr Thr Gly Thr Gly Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  9
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  9
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaagc ccggcgagtc actgagaatt       60

agctgtaaag gttcaggcta caccttcact acctactgga tgcactgggt ccgccaggct      120

accggtcaag gcctcgagtg gatgggtaat atctaccccg gcaccggcgg ctctaacttc      180

gacgagaagt ttaagaatag agtgactatc accgccgata agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcac taggtggact      300

accggcacag gcgcctactg gggtcaaggc actaccgtga ccgtgtctag cgctagcact      360

aagggcccgt ccgtgttccc cctggcacct tgtagccgga gcactagcga atccaccgct      420

gccctcggct gcctggtcaa ggattacttc ccggagcccg tgaccgtgtc ctggaacagc      480

ggagccctga cctccggagt gcacaccttc cccgctgtgc tgcagagctc cgggctgtac      540

tcgctgtcgt cggtggtcac ggtgccttca tctagcctgg gtaccaagac ctacacttgc      600

aacgtggacc acaagccttc caacactaag gtggacaagc gcgtcgaatc gaagtacggc      660

ccaccgtgcc cgccttgtcc cgcgccggag ttcctcggcg gtccctcggt ctttctgttc      720

ccaccgaagc ccaaggacac tttgatgatt tcccgcaccc ctgaagtgac atgcgtggtc      780

gtggacgtgt cacaggaaga tccggaggtg cagttcaatt ggtacgtgga tggcgtcgag      840

gtgcacaacg ccaaaaccaa gccgagggag gagcagttca actccactta ccgcgtcgtg      900

tccgtgctga cggtgctgca tcaggactgg ctgaacggga aggagtacaa gtgcaaagtg      960

tccaacaagg gacttcctag ctcaatcgaa aagaccatct cgaaagccaa gggacagccc     1020

cgggaacccc aagtgtatac cctgccaccg agccaggaag aaatgactaa gaaccaagtc     1080

tcattgactt gccttgtgaa gggcttctac ccatcggata tcgccgtgga atgggagtcc     1140

aacggccagc cggaaaacaa ctacaagacc acccctccgg tgctggactc agacggatcc     1200

ttcttcctct actcgcggct gaccgtggat aagagcagat ggcaggaggg aaatgtgttc     1260

agctgttctg tgatgcatga agccctgcac aaccactaca ctcagaagtc cctgtccctc     1320

tccctggga                                                             1329


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  10

Lys Ser Ser Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Thr 
    


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  11

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  12

Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  13

Ser Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Phe 
1               5                   10              


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  14

Trp Ala Ser 
1           


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  15

Asp Tyr Ser Tyr Pro Tyr 
1               5       


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  17
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  17
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg taaagcccct aagctgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tgcagcccga ggatatcgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaag                             339


<210>  18
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  19
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  19
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg taaagcccct aagctgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tgcagcccga ggatatcgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaagc gtacggtggc cgctcccagc      360

gtgttcatct tcccccccag cgacgagcag ctgaagagcg gcaccgccag cgtggtgtgc      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caacgccctg      480

cagagcggca acagccagga gagcgtcacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcataaggt gtacgcctgc      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaacag gggcgagtgc      660


<210>  20
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  21
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  21
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg tcaagcccct agactgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tggaagccga ggacgccgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaag                             339


<210>  22
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  23
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  23
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg tcaagcccct agactgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tggaagccga ggacgccgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaagc gtacggtggc cgctcccagc      360

gtgttcatct tcccccccag cgacgagcag ctgaagagcg gcaccgccag cgtggtgtgc      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caacgccctg      480

cagagcggca acagccagga gagcgtcacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcataaggt gtacgcctgc      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaacag gggcgagtgc      660


<210>  24
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  24
acctactgga tgcac                                                        15


<210>  25
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  25
aatatctacc ccggcaccgg cggctctaac ttcgacgaga agtttaagaa t                51


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  26
tggactaccg gcacaggcgc ctac                                              24


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  27
ggctacacct tcactaccta c                                                 21


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  28
taccccggca ccggcggc                                                     18


<210>  29
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  29
aaatctagtc agtcactgct ggatagcggt aatcagaaga acttcctgac c                51


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  30
tgggcctcta ctagagaatc a                                                 21


<210>  31
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  31
cagaacgact atagctaccc ctacacc                                           27


<210>  32
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  32
agtcagtcac tgctggatag cggtaatcag aagaacttc                              39


<210>  33
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  33
tgggcctct                                                                9


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  34
gactatagct acccctac                                                     18


<210>  35
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  36
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  37
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Ser Gly Glu Ser Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Thr Ser Leu Thr Ala Glu Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      


Val Arg Val Gly Tyr Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  38
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  38

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Cys Leu Thr Ile Asn Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Phe Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  39

Gly Tyr Thr Phe Thr Thr Tyr Trp Met His 
1               5                   10  


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  40

Asn Tyr Gly Met Asn 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  41

Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  42

Asn Pro Pro Tyr Tyr Tyr Gly Thr Asn Asn Ala Glu Ala Met Asp Tyr 
1               5                   10                  15      


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  43

Gly Phe Thr Leu Thr Asn Tyr 
1               5           


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  44

Asn Thr Asp Thr Gly Glu 
1               5       


<210>  45
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Leu Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Pro Pro Tyr Tyr Tyr Gly Thr Asn Asn Ala Glu Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  46
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  46
caagtgcagc tggtgcagtc gggagccgaa gtgaagaagc ctggagcctc ggtgaaggtg       60

tcgtgcaagg catccggatt caccctcacc aattacggga tgaactgggt cagacaggcc      120

cggggtcaac ggctggagtg gatcggatgg attaacaccg acaccgggga gcctacctac      180

gcggacgatt tcaagggacg gttcgtgttc tccctcgaca cctccgtgtc caccgcctac      240

ctccaaatct cctcactgaa agcggaggac accgccgtgt actattgcgc gaggaacccg      300

ccctactact acggaaccaa caacgccgaa gccatggact actggggcca gggcaccact      360

gtgactgtgt ccagc                                                       375


<210>  47
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  47
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cctctggctt caccctgacc aactacggca tgaactgggt gcgacaggcc      120

aggggccagc ggctggaatg gatcggctgg atcaacaccg acaccggcga gcctacctac      180

gccgacgact tcaagggcag attcgtgttc tccctggaca cctccgtgtc caccgcctac      240

ctgcagatct ccagcctgaa ggccgaggat accgccgtgt actactgcgc ccggaacccc      300

ccttactact acggcaccaa caacgccgag gccatggact attggggcca gggcaccacc      360

gtgaccgtgt cctct                                                       375


<210>  48
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Leu Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Pro Pro Tyr Tyr Tyr Gly Thr Asn Asn Ala Glu Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly 
    450     


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  49

Ser Ser Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  50

Tyr Thr Ser Thr Leu His Leu 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  51

Gln Gln Tyr Tyr Asn Leu Pro Trp Thr 
1               5                   


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  52

Ser Gln Asp Ile Ser Asn Tyr 
1               5           


<210>  53
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  53

Tyr Thr Ser 
1           


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  54

Tyr Tyr Asn Leu Pro Trp 
1               5       


<210>  55
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  55
caagtgcagc tggtgcagtc gggagccgaa gtgaagaagc ctggagcctc ggtgaaggtg       60

tcgtgcaagg catccggatt caccctcacc aattacggga tgaactgggt cagacaggcc      120

cggggtcaac ggctggagtg gatcggatgg attaacaccg acaccgggga gcctacctac      180

gcggacgatt tcaagggacg gttcgtgttc tccctcgaca cctccgtgtc caccgcctac      240

ctccaaatct cctcactgaa agcggaggac accgccgtgt actattgcgc gaggaacccg      300

ccctactact acggaaccaa caacgccgaa gccatggact actggggcca gggcaccact      360

gtgactgtgt ccagcgcgtc cactaagggc ccgtccgtgt tccccctggc accttgtagc      420

cggagcacta gcgaatccac cgctgccctc ggctgcctgg tcaaggatta cttcccggag      480

cccgtgaccg tgtcctggaa cagcggagcc ctgacctccg gagtgcacac cttccccgct      540

gtgctgcaga gctccgggct gtactcgctg tcgtcggtgg tcacggtgcc ttcatctagc      600

ctgggtacca agacctacac ttgcaacgtg gaccacaagc cttccaacac taaggtggac      660

aagcgcgtcg aatcgaagta cggcccaccg tgcccgcctt gtcccgcgcc ggagttcctc      720

ggcggtccct cggtctttct gttcccaccg aagcccaagg acactttgat gatttcccgc      780

acccctgaag tgacatgcgt ggtcgtggac gtgtcacagg aagatccgga ggtgcagttc      840

aattggtacg tggatggcgt cgaggtgcac aacgccaaaa ccaagccgag ggaggagcag      900

ttcaactcca cttaccgcgt cgtgtccgtg ctgacggtgc tgcatcagga ctggctgaac      960

gggaaggagt acaagtgcaa agtgtccaac aagggacttc ctagctcaat cgaaaagacc     1020

atctcgaaag ccaagggaca gccccgggaa ccccaagtgt ataccctgcc accgagccag     1080

gaagaaatga ctaagaacca agtctcattg acttgccttg tgaagggctt ctacccatcg     1140

gatatcgccg tggaatggga gtccaacggc cagccggaaa acaactacaa gaccacccct     1200

ccggtgctgg actcagacgg atccttcttc ctctactcgc ggctgaccgt ggataagagc     1260

agatggcagg agggaaatgt gttcagctgt tctgtgatgc atgaagccct gcacaaccac     1320

tacactcaga agtccctgtc cctctccctg gga                                  1353


<210>  56
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  56
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cctctggctt caccctgacc aactacggca tgaactgggt gcgacaggcc      120

aggggccagc ggctggaatg gatcggctgg atcaacaccg acaccggcga gcctacctac      180

gccgacgact tcaagggcag attcgtgttc tccctggaca cctccgtgtc caccgcctac      240

ctgcagatct ccagcctgaa ggccgaggat accgccgtgt actactgcgc ccggaacccc      300

ccttactact acggcaccaa caacgccgag gccatggact attggggcca gggcaccacc      360

gtgaccgtgt cctctgcttc taccaagggg cccagcgtgt tccccctggc cccctgctcc      420

agaagcacca gcgagagcac agccgccctg ggctgcctgg tgaaggacta cttccccgag      480

cccgtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc      540

gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc      600

ctgggcacca agacctacac ctgtaacgtg gaccacaagc ccagcaacac caaggtggac      660

aagagggtgg agagcaagta cggcccaccc tgccccccct gcccagcccc cgagttcctg      720

ggcggaccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcaga      780

acccccgagg tgacctgtgt ggtggtggac gtgtcccagg aggaccccga ggtccagttc      840

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag      900

tttaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgtaa ggtctccaac aagggcctgc caagcagcat cgaaaagacc     1020

atcagcaagg ccaagggcca gcctagagag ccccaggtct acaccctgcc acccagccaa     1080

gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctacccaagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

ccagtgctgg acagcgacgg cagcttcttc ctgtacagca ggctgaccgt ggacaagtcc     1260

agatggcagg agggcaacgt ctttagctgc tccgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agagcctgag cctgtccctg ggc                                  1353


<210>  57
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ser Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu His Leu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  58
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  58
gatattcaga tgactcagtc acctagtagc ctgagcgcta gtgtgggcga tagagtgact       60

atcacctgta gctctagtca ggatatctct aactacctga actggtatct gcagaagccc      120

ggtcaatcac ctcagctgct gatctactac actagcaccc tgcacctggg cgtgccctct      180

aggtttagcg gtagcggtag tggcaccgag ttcaccctga ctatctctag cctgcagccc      240

gacgacttcg ctacctacta ctgtcagcag tactataacc tgccctggac cttcggtcaa      300

ggcactaagg tcgagattaa g                                                321


<210>  59
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  59
gacatccaga tgacccagtc cccctccagc ctgtctgctt ccgtgggcga cagagtgacc       60

atcacctgtt cctccagcca ggacatctcc aactacctga actggtatct gcagaagccc      120

ggccagtccc ctcagctgct gatctactac acctccaccc tgcacctggg cgtgccctcc      180

agattttccg gctctggctc tggcaccgag tttaccctga ccatcagctc cctgcagccc      240

gacgacttcg ccacctacta ctgccagcag tactacaacc tgccctggac cttcggccag      300

ggcaccaagg tggaaatcaa g                                                321


<210>  60
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ser Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu His Leu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  61
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  61
gatattcaga tgactcagtc acctagtagc ctgagcgcta gtgtgggcga tagagtgact       60

atcacctgta gctctagtca ggatatctct aactacctga actggtatct gcagaagccc      120

ggtcaatcac ctcagctgct gatctactac actagcaccc tgcacctggg cgtgccctct      180

aggtttagcg gtagcggtag tggcaccgag ttcaccctga ctatctctag cctgcagccc      240

gacgacttcg ctacctacta ctgtcagcag tactataacc tgccctggac cttcggtcaa      300

ggcactaagg tcgagattaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  62
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  62
gacatccaga tgacccagtc cccctccagc ctgtctgctt ccgtgggcga cagagtgacc       60

atcacctgtt cctccagcca ggacatctcc aactacctga actggtatct gcagaagccc      120

ggccagtccc ctcagctgct gatctactac acctccaccc tgcacctggg cgtgccctcc      180

agattttccg gctctggctc tggcaccgag tttaccctga ccatcagctc cctgcagccc      240

gacgacttcg ccacctacta ctgccagcag tactacaacc tgccctggac cttcggccag      300

ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttcccccca      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  63
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Leu Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Pro Pro Tyr Tyr Tyr Gly Thr Asn Asn Ala Glu Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  64
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  64
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggcgctag tgtgaaagtc       60

agctgtaaag ctagtggctt caccctgact aactacggga tgaactgggt ccgccaggcc      120

ccaggtcaag gcctcgagtg gatgggctgg attaacaccg acaccggcga gcctacctac      180

gccgacgact ttaagggcag attcgtgttt agcctggaca ctagtgtgtc taccgcctac      240

ctgcagatct ctagcctgaa ggccgaggac accgccgtct actactgcgc tagaaacccc      300

ccctactact acggcactaa caacgccgag gctatggact actggggtca aggcactacc      360

gtgaccgtgt ctagc                                                       375


<210>  65
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  65
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cctctggctt caccctgacc aactacggca tgaactgggt gcgacaggcc      120

cctggacagg gcctggaatg gatgggctgg atcaacaccg acaccggcga gcctacctac      180

gccgacgact tcaagggcag attcgtgttc tccctggaca cctccgtgtc caccgcctac      240

ctgcagatct ccagcctgaa ggccgaggat accgccgtgt actactgcgc ccggaacccc      300

ccttactact acggcaccaa caacgccgag gccatggact attggggcca gggcaccacc      360

gtgaccgtgt cctct                                                       375


<210>  66
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Leu Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Pro Pro Tyr Tyr Tyr Gly Thr Asn Asn Ala Glu Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly 
    450     


<210>  67
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  67
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggcgctag tgtgaaagtc       60

agctgtaaag ctagtggctt caccctgact aactacggga tgaactgggt ccgccaggcc      120

ccaggtcaag gcctcgagtg gatgggctgg attaacaccg acaccggcga gcctacctac      180

gccgacgact ttaagggcag attcgtgttt agcctggaca ctagtgtgtc taccgcctac      240

ctgcagatct ctagcctgaa ggccgaggac accgccgtct actactgcgc tagaaacccc      300

ccctactact acggcactaa caacgccgag gctatggact actggggtca aggcactacc      360

gtgaccgtgt ctagcgctag cactaagggc ccgtccgtgt tccccctggc accttgtagc      420

cggagcacta gcgaatccac cgctgccctc ggctgcctgg tcaaggatta cttcccggag      480

cccgtgaccg tgtcctggaa cagcggagcc ctgacctccg gagtgcacac cttccccgct      540

gtgctgcaga gctccgggct gtactcgctg tcgtcggtgg tcacggtgcc ttcatctagc      600

ctgggtacca agacctacac ttgcaacgtg gaccacaagc cttccaacac taaggtggac      660

aagcgcgtcg aatcgaagta cggcccaccg tgcccgcctt gtcccgcgcc ggagttcctc      720

ggcggtccct cggtctttct gttcccaccg aagcccaagg acactttgat gatttcccgc      780

acccctgaag tgacatgcgt ggtcgtggac gtgtcacagg aagatccgga ggtgcagttc      840

aattggtacg tggatggcgt cgaggtgcac aacgccaaaa ccaagccgag ggaggagcag      900

ttcaactcca cttaccgcgt cgtgtccgtg ctgacggtgc tgcatcagga ctggctgaac      960

gggaaggagt acaagtgcaa agtgtccaac aagggacttc ctagctcaat cgaaaagacc     1020

atctcgaaag ccaagggaca gccccgggaa ccccaagtgt ataccctgcc accgagccag     1080

gaagaaatga ctaagaacca agtctcattg acttgccttg tgaagggctt ctacccatcg     1140

gatatcgccg tggaatggga gtccaacggc cagccggaaa acaactacaa gaccacccct     1200

ccggtgctgg actcagacgg atccttcttc ctctactcgc ggctgaccgt ggataagagc     1260

agatggcagg agggaaatgt gttcagctgt tctgtgatgc atgaagccct gcacaaccac     1320

tacactcaga agtccctgtc cctctccctg gga                                  1353


<210>  68
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  68
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cctctggctt caccctgacc aactacggca tgaactgggt gcgacaggcc      120

cctggacagg gcctggaatg gatgggctgg atcaacaccg acaccggcga gcctacctac      180

gccgacgact tcaagggcag attcgtgttc tccctggaca cctccgtgtc caccgcctac      240

ctgcagatct ccagcctgaa ggccgaggat accgccgtgt actactgcgc ccggaacccc      300

ccttactact acggcaccaa caacgccgag gccatggact attggggcca gggcaccacc      360

gtgaccgtgt cctctgcttc taccaagggg cccagcgtgt tccccctggc cccctgctcc      420

agaagcacca gcgagagcac agccgccctg ggctgcctgg tgaaggacta cttccccgag      480

cccgtgaccg tgtcctggaa cagcggagcc ctgaccagcg gcgtgcacac cttccccgcc      540

gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc      600

ctgggcacca agacctacac ctgtaacgtg gaccacaagc ccagcaacac caaggtggac      660

aagagggtgg agagcaagta cggcccaccc tgccccccct gcccagcccc cgagttcctg      720

ggcggaccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcaga      780

acccccgagg tgacctgtgt ggtggtggac gtgtcccagg aggaccccga ggtccagttc      840

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag      900

tttaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgtaa ggtctccaac aagggcctgc caagcagcat cgaaaagacc     1020

atcagcaagg ccaagggcca gcctagagag ccccaggtct acaccctgcc acccagccaa     1080

gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctacccaagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

ccagtgctgg acagcgacgg cagcttcttc ctgtacagca ggctgaccgt ggacaagtcc     1260

agatggcagg agggcaacgt ctttagctgc tccgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agagcctgag cctgtccctg ggc                                  1353


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ser Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu His Leu Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln Tyr Tyr Asn Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  70
gatattcaga tgactcagtc acctagtagc ctgagcgcta gtgtgggcga tagagtgact       60

atcacctgta gctctagtca ggatatctct aactacctga actggtatca gcagaagccc      120

ggtaaagccc ctaagctgct gatctactac actagcaccc tgcacctggg aatcccccct      180

aggtttagcg gtagcggcta cggcaccgac ttcaccctga ctattaacaa tatcgagtca      240

gaggacgccg cctactactt ctgtcagcag tactataacc tgccctggac cttcggtcaa      300

ggcactaagg tcgagattaa g                                                321


<210>  71
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  71
gacatccaga tgacccagtc cccctccagc ctgtctgctt ccgtgggcga cagagtgacc       60

atcacctgtt cctccagcca ggacatctcc aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctccaccc tgcacctggg catcccccct      180

agattctccg gctctggcta cggcaccgac ttcaccctga ccatcaacaa catcgagtcc      240

gaggacgccg cctactactt ctgccagcag tactacaacc tgccctggac cttcggccag      300

ggcaccaagg tggaaatcaa g                                                321


<210>  72
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ser Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu His Leu Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln Tyr Tyr Asn Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  73
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  73
gatattcaga tgactcagtc acctagtagc ctgagcgcta gtgtgggcga tagagtgact       60

atcacctgta gctctagtca ggatatctct aactacctga actggtatca gcagaagccc      120

ggtaaagccc ctaagctgct gatctactac actagcaccc tgcacctggg aatcccccct      180

aggtttagcg gtagcggcta cggcaccgac ttcaccctga ctattaacaa tatcgagtca      240

gaggacgccg cctactactt ctgtcagcag tactataacc tgccctggac cttcggtcaa      300

ggcactaagg tcgagattaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  74
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  74
gacatccaga tgacccagtc cccctccagc ctgtctgctt ccgtgggcga cagagtgacc       60

atcacctgtt cctccagcca ggacatctcc aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctccaccc tgcacctggg catcccccct      180

agattctccg gctctggcta cggcaccgac ttcaccctga ccatcaacaa catcgagtcc      240

gaggacgccg cctactactt ctgccagcag tactacaacc tgccctggac cttcggccag      300

ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttcccccca      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  75
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  75
aattacggga tgaac                                                        15


<210>  76
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  76
aactacggca tgaac                                                        15


<210>  77
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  77
tggattaaca ccgacaccgg ggagcctacc tacgcggacg atttcaaggg a                51


<210>  78
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  78
tggatcaaca ccgacaccgg cgagcctacc tacgccgacg acttcaaggg c                51


<210>  79
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  79
aacccgccct actactacgg aaccaacaac gccgaagcca tggactac                    48


<210>  80
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  80
aacccccctt actactacgg caccaacaac gccgaggcca tggactat                    48


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  81
ggattcaccc tcaccaatta c                                                 21


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  82
ggcttcaccc tgaccaacta c                                                 21


<210>  83
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  83
aacaccgaca ccggggag                                                     18


<210>  84
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  84
aacaccgaca ccggcgag                                                     18


<210>  85
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  85
agctctagtc aggatatctc taactacctg aac                                    33


<210>  86
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  86
tcctccagcc aggacatctc caactacctg aac                                    33


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  87
tacactagca ccctgcacct g                                                 21


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  88
tacacctcca ccctgcacct g                                                 21


<210>  89
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  89
cagcagtact ataacctgcc ctggacc                                           27


<210>  90
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  90
cagcagtact acaacctgcc ctggacc                                           27


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  91
agtcaggata tctctaacta c                                                 21


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  92
agccaggaca tctccaacta c                                                 21


<210>  93
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  93
tacactagc                                                                9


<210>  94
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  94
tacacctcc                                                                9


<210>  95
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  95
tactataacc tgccctgg                                                     18


<210>  96
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  96
tactacaacc tgccctgg                                                     18


<210>  97
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  97
aactacggga tgaac                                                        15


<210>  98
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  98
tggattaaca ccgacaccgg cgagcctacc tacgccgacg actttaaggg c                51


<210>  99
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  99
aaccccccct actactacgg cactaacaac gccgaggcta tggactac                    48


<210>  100
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  100
ggcttcaccc tgactaacta c                                                 21


<210>  101
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  101

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Phe Gly Tyr Ser Asp Tyr Glu Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  102
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  102

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  103
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  103

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  104
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  104

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  105

Gly Phe Thr Leu Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  106

Ser Tyr Asn Met His 
1               5   


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  107

Asp Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  108

Val Gly Gly Ala Phe Pro Met Asp Tyr 
1               5                   


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  109

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  110
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  110

Tyr Pro Gly Asn Gly Asp 
1               5       


<210>  111
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  111

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Ala Phe Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  112
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  112
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtt       60

tcttgtaaag ctagtggcta caccttcact agctataata tgcactgggt tcgccaggcc      120

ccagggcaag gcctcgagtg gatgggcgat atctaccccg ggaacggcga cactagttat      180

aatcagaagt ttaagggtag agtcactatc accgccgata agtctactag caccgtctat      240

atggaactga gttccctgag gtctgaggac accgccgtct actactgcgc tagagtgggc      300

ggagccttcc ctatggacta ctggggtcaa ggcactaccg tgaccgtgtc tagc            354


<210>  113
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  113

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Ala Phe Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 


<210>  114
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  114
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtt       60

tcttgtaaag ctagtggcta caccttcact agctataata tgcactgggt tcgccaggcc      120

ccagggcaag gcctcgagtg gatgggcgat atctaccccg ggaacggcga cactagttat      180

aatcagaagt ttaagggtag agtcactatc accgccgata agtctactag caccgtctat      240

atggaactga gttccctgag gtctgaggac accgccgtct actactgcgc tagagtgggc      300

ggagccttcc ctatggacta ctggggtcaa ggcactaccg tgaccgtgtc tagcgctagc      360

actaagggcc cgtccgtgtt ccccctggca ccttgtagcc ggagcactag cgaatccacc      420

gctgccctcg gctgcctggt caaggattac ttcccggagc ccgtgaccgt gtcctggaac      480

agcggagccc tgacctccgg agtgcacacc ttccccgctg tgctgcagag ctccgggctg      540

tactcgctgt cgtcggtggt cacggtgcct tcatctagcc tgggtaccaa gacctacact      600

tgcaacgtgg accacaagcc ttccaacact aaggtggaca agcgcgtcga atcgaagtac      660

ggcccaccgt gcccgccttg tcccgcgccg gagttcctcg gcggtccctc ggtctttctg      720

ttcccaccga agcccaagga cactttgatg atttcccgca cccctgaagt gacatgcgtg      780

gtcgtggacg tgtcacagga agatccggag gtgcagttca attggtacgt ggatggcgtc      840

gaggtgcaca acgccaaaac caagccgagg gaggagcagt tcaactccac ttaccgcgtc      900

gtgtccgtgc tgacggtgct gcatcaggac tggctgaacg ggaaggagta caagtgcaaa      960

gtgtccaaca agggacttcc tagctcaatc gaaaagacca tctcgaaagc caagggacag     1020

ccccgggaac cccaagtgta taccctgcca ccgagccagg aagaaatgac taagaaccaa     1080

gtctcattga cttgccttgt gaagggcttc tacccatcgg atatcgccgt ggaatgggag     1140

tccaacggcc agccggaaaa caactacaag accacccctc cggtgctgga ctcagacgga     1200

tccttcttcc tctactcgcg gctgaccgtg gataagagca gatggcagga gggaaatgtg     1260

ttcagctgtt ctgtgatgca tgaagccctg cacaaccact acactcagaa gtccctgtcc     1320

ctctccctgg ga                                                         1332


<210>  115
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  115

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln 
1               5                   10                  15  


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  116

Ala Ala Ser Asn Val Glu Ser 
1               5           


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  117

Gln Gln Ser Arg Lys Asp Pro Ser Thr 
1               5                   


<210>  118
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  118

Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
1               5                   10      


<210>  119
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  119

Ala Ala Ser 
1           


<210>  120
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  120

Ser Arg Lys Asp Pro Ser 
1               5       


<210>  121
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  121

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Asp Pro Ser Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  122
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  122
gctattcagc tgactcagtc acctagtagc ctgagcgcta gtgtgggcga tagagtgact       60

atcacctgta gagctagtga atcagtcgag tactacggca ctagcctgat gcagtggtat      120

cagcagaagc ccgggaaagc ccctaagctg ctgatctacg ccgcctctaa cgtggaatca      180

ggcgtgccct ctaggtttag cggtagcggt agtggcaccg acttcaccct gactatctct      240

agcctgcagc ccgaggactt cgctacctac ttctgtcagc agtctaggaa ggaccctagc      300

accttcggcg gaggcactaa ggtcgagatt aag                                   333


<210>  123
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  123

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Asp Pro Ser Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  124
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  124
gctattcagc tgactcagtc acctagtagc ctgagcgcta gtgtgggcga tagagtgact       60

atcacctgta gagctagtga atcagtcgag tactacggca ctagcctgat gcagtggtat      120

cagcagaagc ccgggaaagc ccctaagctg ctgatctacg ccgcctctaa cgtggaatca      180

ggcgtgccct ctaggtttag cggtagcggt agtggcaccg acttcaccct gactatctct      240

agcctgcagc ccgaggactt cgctacctac ttctgtcagc agtctaggaa ggaccctagc      300

accttcggcg gaggcactaa ggtcgagatt aagcgtacgg tggccgctcc cagcgtgttc      360

atcttccccc ccagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgcctgctg      420

aacaacttct acccccggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc      480

ggcaacagcc aggagagcgt caccgagcag gacagcaagg actccaccta cagcctgagc      540

agcaccctga ccctgagcaa ggccgactac gagaagcata aggtgtacgc ctgcgaggtg      600

acccaccagg gcctgtccag ccccgtgacc aagagcttca acaggggcga gtgc            654


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  125

Asp Ile Tyr Pro Gly Gln Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  126

Tyr Pro Gly Gln Gly Asp 
1               5       


<210>  127
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  127

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gln Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Ala Phe Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  128
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  128
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggcgctag tgtgaaagtt       60

agctgtaaag ctagtggcta tactttcact tcttataata tgcactgggt ccgccaggcc      120

ccaggtcaag gcctcgagtg gatcggcgat atctaccccg gtcaaggcga cacttcctat      180

aatcagaagt ttaagggtag agctactatg accgccgata agtctacttc taccgtctat      240

atggaactga gttccctgag gtctgaggac accgccgtct actactgcgc tagagtgggc      300

ggagccttcc caatggacta ctggggtcaa ggcaccctgg tcaccgtgtc tagc            354


<210>  129
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  129

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gln Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Ala Phe Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 


<210>  130
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  130
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggcgctag tgtgaaagtt       60

agctgtaaag ctagtggcta tactttcact tcttataata tgcactgggt ccgccaggcc      120

ccaggtcaag gcctcgagtg gatcggcgat atctaccccg gtcaaggcga cacttcctat      180

aatcagaagt ttaagggtag agctactatg accgccgata agtctacttc taccgtctat      240

atggaactga gttccctgag gtctgaggac accgccgtct actactgcgc tagagtgggc      300

ggagccttcc caatggacta ctggggtcaa ggcaccctgg tcaccgtgtc tagcgctagc      360

actaagggcc cgtccgtgtt ccccctggca ccttgtagcc ggagcactag cgaatccacc      420

gctgccctcg gctgcctggt caaggattac ttcccggagc ccgtgaccgt gtcctggaac      480

agcggagccc tgacctccgg agtgcacacc ttccccgctg tgctgcagag ctccgggctg      540

tactcgctgt cgtcggtggt cacggtgcct tcatctagcc tgggtaccaa gacctacact      600

tgcaacgtgg accacaagcc ttccaacact aaggtggaca agcgcgtcga atcgaagtac      660

ggcccaccgt gcccgccttg tcccgcgccg gagttcctcg gcggtccctc ggtctttctg      720

ttcccaccga agcccaagga cactttgatg atttcccgca cccctgaagt gacatgcgtg      780

gtcgtggacg tgtcacagga agatccggag gtgcagttca attggtacgt ggatggcgtc      840

gaggtgcaca acgccaaaac caagccgagg gaggagcagt tcaactccac ttaccgcgtc      900

gtgtccgtgc tgacggtgct gcatcaggac tggctgaacg ggaaggagta caagtgcaaa      960

gtgtccaaca agggacttcc tagctcaatc gaaaagacca tctcgaaagc caagggacag     1020

ccccgggaac cccaagtgta taccctgcca ccgagccagg aagaaatgac taagaaccaa     1080

gtctcattga cttgccttgt gaagggcttc tacccatcgg atatcgccgt ggaatgggag     1140

tccaacggcc agccggaaaa caactacaag accacccctc cggtgctgga ctcagacgga     1200

tccttcttcc tctactcgcg gctgaccgtg gataagagca gatggcagga gggaaatgtg     1260

ttcagctgtt ctgtgatgca tgaagccctg cacaaccact acactcagaa gtccctgtcc     1320

ctctccctgg ga                                                         1332


<210>  131
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  131

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Asp Pro Ser Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  132
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  132
gatatcgtcc tgactcagtc acccgatagc ctggccgtca gcctgggcga gcgggctact       60

attaactgta gagctagtga atcagtcgag tactacggca ctagcctgat gcagtggtat      120

cagcagaagc ccggtcaacc ccctaagctg ctgatctacg ccgcctctaa cgtggaatca      180

ggcgtgcccg ataggtttag cggtagcggt agtggcaccg acttcaccct gactattagt      240

agcctgcagg ccgaggacgt ggccgtctac tactgtcagc agtctaggaa ggaccctagc      300

accttcggcg gaggcactaa ggtcgagatt aag                                   333


<210>  133
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  133

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Asp Pro Ser Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  134
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  134
gatatcgtcc tgactcagtc acccgatagc ctggccgtca gcctgggcga gcgggctact       60

attaactgta gagctagtga atcagtcgag tactacggca ctagcctgat gcagtggtat      120

cagcagaagc ccggtcaacc ccctaagctg ctgatctacg ccgcctctaa cgtggaatca      180

ggcgtgcccg ataggtttag cggtagcggt agtggcaccg acttcaccct gactattagt      240

agcctgcagg ccgaggacgt ggccgtctac tactgtcagc agtctaggaa ggaccctagc      300

accttcggcg gaggcactaa ggtcgagatt aagcgtacgg tggccgctcc cagcgtgttc      360

atcttccccc ccagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgcctgctg      420

aacaacttct acccccggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc      480

ggcaacagcc aggagagcgt caccgagcag gacagcaagg actccaccta cagcctgagc      540

agcaccctga ccctgagcaa ggccgactac gagaagcata aggtgtacgc ctgcgaggtg      600

acccaccagg gcctgtccag ccccgtgacc aagagcttca acaggggcga gtgc            654


<210>  135
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  135

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp 
        35                  40                  45              


Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Thr Tyr Tyr Gln Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser Ala 
        


<210>  136
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  136

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr His Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser His Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  137
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  137

Glu Val Gln Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Tyr Cys Val Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Lys Tyr Tyr Val Gly Pro Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly 
        115                 120 


<210>  138
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  138

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Ile Glu Val 
            100                 105                 110         


Lys 
    


<210>  139
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  140
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  140

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  141
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  142
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  142

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  143
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  143
gaggtgcagc tggtggaatc tggcggcgga ctggtgcagt ccggcggctc tctgagactg       60

tcttgcgctg cctccggctt ctccctgtcc tcttacggcg tggactgggt gcgacaggcc      120

cctggcaagg gcctggaatg ggtgggagtg atctggggcg gaggcggcac ctactacgcc      180

tcttccctga tgggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgcgccag acacgcctac      300

ggccacgacg gcggcttcgc catggattat tggggccagg gcaccctggt gacagtgtcc      360

tcc                                                                    363


<210>  144
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  144
gagatcgtga tgacccagtc ccccgccacc ctgtctgtgt ctcccggcga gagagccacc       60

ctgagctgca gagcctccga gtccgtgtcc tccaacgtgg cctggtatca gcagagacct      120

ggtcaggccc ctcggctgct gatctacggc gcctctaacc gggccaccgg catccctgcc      180

agattctccg gctccggcag cggcaccgac ttcaccctga ccatctcccg gctggaaccc      240

gaggacttcg ccgtgtacta ctgcggccag tcctactcat accccttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  145
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  145
gaggtgcagc tggtggaatc tggcggcgga ctggtgcagt ccggcggctc tctgagactg       60

tcttgcgctg cctccggctt ctccctgtcc tcttacggcg tggactgggt gcgacaggcc      120

cctggcaagg gcctggaatg ggtgggagtg atctggggcg gaggcggcac ctactacgcc      180

tcttccctga tgggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgcgccag acacgcctac      300

ggccacgacg gcggcttcgc catggattat tggggccagg gcaccctggt gacagtgtcc      360

tccgctagca ccaagggccc aagtgtgttt cccctggccc ccagcagcaa gtctacttcc      420

ggcggaactg ctgccctggg ttgcctggtg aaggactact tccccgagcc cgtgacagtg      480

tcctggaact ctggggctct gacttccggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtg acagtgccct ccagctctct gggaacccag      600

acctatatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc cagctccaga actgctggga      720

gggccttccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc      780

cccgaggtga cctgcgtggt ggtggacgtg tcccacgagg acccagaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac      900

aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaagaataca agtgcaaagt ctccaacaag gccctgccag ccccaatcga aaagacaatc     1020

agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc cagccgggag     1080

gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta ccccagcgat     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgagcct gagccccggc aag                                  1353


<210>  146
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  146
gagatcgtga tgacccagtc ccccgccacc ctgtctgtgt ctcccggcga gagagccacc       60

ctgagctgca gagcctccga gtccgtgtcc tccaacgtgg cctggtatca gcagagacct      120

ggtcaggccc ctcggctgct gatctacggc gcctctaacc gggccaccgg catccctgcc      180

agattctccg gctccggcag cggcaccgac ttcaccctga ccatctcccg gctggaaccc      240

gaggacttcg ccgtgtacta ctgcggccag tcctactcat accccttcac cttcggccag      300

ggcaccaagc tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  147
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  147

Ser Tyr Gly Val Asp 
1               5   


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  148

Gly Phe Ser Leu Ser Ser Tyr 
1               5           


<210>  149
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  149

Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met Gly 
1               5                   10                  15      


<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  150

Trp Gly Gly Gly Gly 
1               5   


<210>  151
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  151

His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr 
1               5                   10              


<210>  152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  152

Arg Ala Ser Glu Ser Val Ser Ser Asn Val Ala 
1               5                   10      


<210>  153
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  153

Ser Glu Ser Val Ser Ser Asn 
1               5           


<210>  154
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  154

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  155
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  155

Gly Ala Ser 
1           


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  156

Gly Gln Ser Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  157
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  157

Ser Tyr Ser Tyr Pro Phe 
1               5       


<210>  158
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  158

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Glu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Met Val Arg Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  159
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  159

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  160
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  160

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  161
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  161

Glu Thr Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  162
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  162

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Trp Glu Val Arg Ala Leu Pro Ser Val Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  163
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  163

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Ala Asn Asp Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ala Gly Gln Ala Pro Val Leu Val Val Ser 
        35                  40                  45              


Glu Asp Ile Ile Arg Pro Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Arg Asp Ser Asp Gln 
                85                  90                  95      


Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 


<210>  164
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  164

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  165
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  165

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
                165                 170 


<210>  166
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  166

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  167
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  167

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
65                  70                  75                  80  


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                85                  90                  95      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        115                 120                 125             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    130                 135                 140                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
145                 150                 155                 160 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                165                 170                 175     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            180                 185                 190         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        195                 200                 205             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    210                 215                 220                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
225                 230                 235                 240 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                245                 250                 255     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            260                 265                 270         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        275                 280                 285             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295         


<210>  168
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  168

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  169
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  169

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Lys Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  170
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody fragment

<400>  170

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro 
65                  70                  75          


<210>  171
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  171

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Leu Tyr Arg Ser Pro 
1               5                   10                  15      


Ala Met Pro Glu Asn Leu 
            20          


