                         SEQUENCE LISTING

<110>  Koninklijke Philips N.V.
 
<120>  Prediction of a response of a prostate cancer subject to therapy 
       or personalization of therapy of a prostate cancer subject

<130>  2020PF00492

<160>  166   

<170>  PatentIn version 3.5

<210>  1
<211>  2009
<212>  DNA
<213>  Homo sapiens

<400>  1
gggaatgctt tgtgcagcgc gcttgcgcgg tgtggcggcc gatgccgcta taaaggcttg       60

ttttgctgca gggctcatgc tcgggagcgt ggttgagcgg ctggcgcggt tgtcctggag      120

caggggcgca ggaattctga tgtgaaacta acagtctgtg agccctggaa cctccactca      180

gagaagatga aggatatcga cataggaaaa gagtatatca tccccagtcc tgggtataga      240

agtgtgaggg agagaaccag cacttctggg acgcacagag accgtgaaga ttccaagttc      300

aggagaactc gaccgttgga atgccaagat gccttggaaa cagcagcccg agccgagggc      360

ctctctcttg atgcctccat gcattctcag ctcagaatcc tggatgagga gcatcccaag      420

ggaaagtacc atcatggctt gagtgctctg aagcccatcc ggactacttc caaacaccag      480

cacccagtgg acaatgctgg gcttttttcc tgtatgactt tttcgtggct ttcttctctg      540

gcccgtgtgg cccacaagaa gggggagctc tcaatggaag acgtgtggtc tctgtccaag      600

cacgagtctt ctgacgtgaa ctgcagaaga ctagagagac tgtggcaaga agagctgaat      660

gaagttgggc cagacgctgc ttccctgcga agggttgtgt ggatcttctg ccgcaccagg      720

ctcatcctgt ccatcgtgtg cctgatgatc acgcagctgg ctggcttcag tggaccaaat      780

tttcaggatg gctgtattct gcggtcagaa tgagagagtc aagctgggca gaatctctcg      840

ccaagagttc agccttcctt tggagactgc tccatcagtg ccgaggtgtg tgggaacagg      900

cttcactgca ccgccatctt actgagttgc ttcacgtgag gaaaaggggg ctttggccct      960

gtgactcagt tccacatttt ggattgcata ctggaaaaga agccaatctt cttgctagta     1020

aaccagcaac ccggctgtat acagtggtga cccaagcaat ggatataaac ctaaaaatct     1080

gagggagggg agaggtggaa tacagtagtt cttggaatct gaagtctcct atttgatcag     1140

gttatttcct gggacttggc aaaaatctga ttggtgggga tctcctagga cctagtggac     1200

atctggtatt aatttaatct caggaaaaac aagaaattaa cccagagaga gtctgggttt     1260

tggaattcag cgtagctacc tccagaccgt ggtgtctggc ctccattttt gtctgtcatt     1320

cagctctgac ttacagctgc agtcaccttt gctataaggc acctgggtag aagggtggat     1380

gggcttcaca tcaatttttt tcttccttta gggtggggga ttggtttggc tttcttttgt     1440

tgtggttttt tgttttattt ttgtcaagat tgatttttag atgcaaggac ttgaaaagac     1500

ccagaaggat gccaccagtt tttccttgag gcctaggatt ttttattctg tcccgagcag     1560

aggtaattcc tcacaactta gtgcaccagt agcaccagcc attttgagca gagtacctct     1620

ttggggagct tttcgttttg ttttgttttt aattctcttt ccttagcagc aaggtctttt     1680

ttcctagaga atctactccg ttgcagaatc attgcaacct caggagccct cactgattga     1740

gtgctgtcag cctgatatac tactttggac tctggaaaca gatatgggtt ctattctcta     1800

tttctactgt gtgtcgttaa acaaccgtcg gagaccagat gacctgttag atggctagtc     1860

ctgtataact cgactctgta tgtttcaatg tatgttactg caatgcttca cctgctgtac     1920

agtgtttgtg agatgctctt tgaagatggt acttttatat tttttcattt tcaataaaag     1980

tacattcctt cccacaaaaa aaaaaaaaa                                       2009


<210>  2
<211>  5872
<212>  DNA
<213>  Homo sapiens

<400>  2
gggaatgctt tgtgcagcgc gcttgcgcgg tgtggcggcc gatgccgcta taaaggcttg       60

ttttgctgca gggctcatgc tcgggagcgt ggttgagcgg ctggcgcggt tgtcctggag      120

caggggcgca ggaattctga tgtgaaacta acagtctgtg agccctggaa cctccactca      180

gagaagatga aggatatcga cataggaaaa gagtatatca tccccagtcc tgggtataga      240

agtgtgaggg agagaaccag cacttctggg acgcacagag accgtgaaga ttccaagttc      300

aggagaactc gaccgttgga atgccaagat gccttggaaa cagcagcccg agccgagggc      360

ctctctcttg atgcctccat gcattctcag ctcagaatcc tggatgagga gcatcccaag      420

ggaaagtacc atcatggctt gagtgctctg aagcccatcc ggactacttc caaacaccag      480

cacccagtgg acaatgctgg gcttttttcc tgtatgactt tttcgtggct ttcttctctg      540

gcccgtgtgg cccacaagaa gggggagctc tcaatggaag acgtgtggtc tctgtccaag      600

cacgagtctt ctgacgtgaa ctgcagaaga ctagagagac tgtggcaaga agagctgaat      660

gaagttgggc cagacgctgc ttccctgcga agggttgtgt ggatcttctg ccgcaccagg      720

ctcatcctgt ccatcgtgtg cctgatgatc acgcagctgg ctggcttcag tggaccagcc      780

ttcatggtga aacacctctt ggagtatacc caggcaacag agtctaacct gcagtacagc      840

ttgttgttag tgctgggcct cctcctgacg gaaatcgtgc ggtcttggtc gcttgcactg      900

acttgggcat tgaattaccg aaccggtgtc cgcttgcggg gggccatcct aaccatggca      960

tttaagaaga tccttaagtt aaagaacatt aaagagaaat ccctgggtga gctcatcaac     1020

atttgctcca acgatgggca gagaatgttt gaggcagcag ccgttggcag cctgctggct     1080

ggaggacccg ttgttgccat cttaggcatg atttataatg taattattct gggaccaaca     1140

ggcttcctgg gatcagctgt ttttatcctc ttttacccag caatgatgtt tgcatcacgg     1200

ctcacagcat atttcaggag aaaatgcgtg gccgccacgg atgaacgtgt ccagaagatg     1260

aatgaagttc ttacttacat taaatttatc aaaatgtatg cctgggtcaa agcattttct     1320

cagagtgttc aaaaaatccg cgaggaggag cgtcggatat tggaaaaagc tgggtacttc     1380

cagagcatca ctgtgggtgt ggctcccatt gtggtggtga ttgccagcgt ggtgaccttc     1440

tctgttcata tgaccctggg cttcgatctg acagcagcac aggctttcac agtggtgaca     1500

gtcttcaatt ccatgacttt tgctttgaaa gtaacaccgt tttcagtaaa gtccctctca     1560

gaagcctcag tggctgttga cagatttaag agtttgtttc taatggaaga ggttcacatg     1620

ataaagaaca aaccagccag tcctcacatc aagatagaga tgaaaaatgc caccttggca     1680

tgggactcct cccactccag tatccagaac tcgcccaagc tgacccccaa aatgaaaaaa     1740

gacaagaggg cttccagggg caagaaagag aaggtgaggc agctgcagcg cactgagcat     1800

caggcggtgc tggcagagca gaaaggccac ctcctcctgg acagtgacga gcggcccagt     1860

cccgaagagg aagaaggcaa gcacatccac ctgggccacc tgcgcttaca gaggacactg     1920

cacagcatcg atctggagat ccaagagggt aaactggttg gaatctgtgg cagtgtggga     1980

agtggaaaaa cctctctcat ttcagccatt ttaggccaga tgacgcttct agagggcagc     2040

attgcaatca gtggaacctt cgcttatgtg gcccagcagg cctggatcct caatgctact     2100

ctgagagaca acatcctgtt tgggaaggaa tatgatgaag aaagatacaa ctctgtgctg     2160

aacagctgct gcctgaggcc tgacctggcc attcttccca gcagcgacct gacggagatt     2220

ggagagcgag gagccaacct gagcggtggg cagcgccaga ggatcagcct tgcccgggcc     2280

ttgtatagtg acaggagcat ctacatcctg gacgaccccc tcagtgcctt agatgcccat     2340

gtgggcaacc acatcttcaa tagtgctatc cggaaacatc tcaagtccaa gacagttctg     2400

tttgttaccc accagttaca gtacctggtt gactgtgatg aagtgatctt catgaaagag     2460

ggctgtatta cggaaagagg cacccatgag gaactgatga atttaaatgg tgactatgct     2520

accattttta ataacctgtt gctgggagag acaccgccag ttgagatcaa ttcaaaaaag     2580

gaaaccagtg gttcacagaa gaagtcacaa gacaagggtc ctaaaacagg atcagtaaag     2640

aaggaaaaag cagtaaagcc agaggaaggg cagcttgtgc agctggaaga gaaagggcag     2700

ggttcagtgc cctggtcagt atatggtgtc tacatccagg ctgctggggg ccccttggca     2760

ttcctggtta ttatggccct tttcatgctg aatgtaggca gcaccgcctt cagcacctgg     2820

tggttgagtt actggatcaa gcaaggaagc gggaacacca ctgtgactcg agggaacgag     2880

acctcggtga gtgacagcat gaaggacaat cctcatatgc agtactatgc cagcatctac     2940

gccctctcca tggcagtcat gctgatcctg aaagccattc gaggagttgt ctttgtcaag     3000

ggcacgctgc gagcttcctc ccggctgcat gacgagcttt tccgaaggat ccttcgaagc     3060

cctatgaagt tttttgacac gacccccaca gggaggattc tcaacaggtt ttccaaagac     3120

atggatgaag ttgacgtgcg gctgccgttc caggccgaga tgttcatcca gaacgttatc     3180

ctggtgttct tctgtgtggg aatgatcgca ggagtcttcc cgtggttcct tgtggcagtg     3240

gggccccttg tcatcctctt ttcagtcctg cacattgtct ccagggtcct gattcgggag     3300

ctgaagcgtc tggacaatat cacgcagtca cctttcctct cccacatcac gtccagcata     3360

cagggccttg ccaccatcca cgcctacaat aaagggcagg agtttctgca cagataccag     3420

gagctgctgg atgacaacca agctcctttt tttttgttta cgtgtgcgat gcggtggctg     3480

gctgtgcggc tggacctcat cagcatcgcc ctcatcacca ccacggggct gatgatcgtt     3540

cttatgcacg ggcagattcc cccagcctat gcgggtctcg ccatctctta tgctgtccag     3600

ttaacggggc tgttccagtt tacggtcaga ctggcatctg agacagaagc tcgattcacc     3660

tcggtggaga ggatcaatca ctacattaag actctgtcct tggaagcacc tgccagaatt     3720

aagaacaagg ctccctcccc tgactggccc caggagggag aggtgacctt tgagaacgca     3780

gagatgaggt accgagaaaa cctccctctc gtcctaaaga aagtatcctt cacgatcaaa     3840

cctaaagaga agattggcat tgtggggcgg acaggatcag ggaagtcctc gctggggatg     3900

gccctcttcc gtctggtgga gttatctgga ggctgcatca agattgatgg agtgagaatc     3960

agtgatattg gccttgccga cctccgaagc aaactctcta tcattcctca agagccggtg     4020

ctgttcagtg gcactgtcag atcaaatttg gaccccttca accagtacac tgaagaccag     4080

atttgggatg ccctggagag gacacacatg aaagaatgta ttgctcagct acctctgaaa     4140

cttgaatctg aagtgatgga gaatggggat aacttctcag tgggggaacg gcagctcttg     4200

tgcatagcta gagccctgct ccgccactgt aagattctga ttttagatga agccacagct     4260

gccatggaca cagagacaga cttattgatt caagagacca tccgagaagc atttgcagac     4320

tgtaccatgc tgaccattgc ccatcgcctg cacacggttc taggctccga taggattatg     4380

gtgctggccc agggacaggt ggtggagttt gacaccccat cggtccttct gtccaacgac     4440

agttcccgat tctatgccat gtttgctgct gcagagaaca aggtcgctgt caagggctga     4500

ctcctccctg ttgacgaagt ctcttttctt tagagcattg ccattccctg cctggggcgg     4560

gcccctcatc gcgtcctcct accgaaacct tgcctttctc gattttatct ttcgcacagc     4620

agttccggat tggcttgtgt gtttcacttt tagggagagt catattttga ttattgtatt     4680

tattccatat tcatgtaaac aaaatttagt ttttgttctt aattgcactc taaaaggttc     4740

agggaaccgt tattataatt gtatcagagg cctataatga agctttatac gtgtagctat     4800

atctatatat aattctgtac atagcctata tttacagtga aaatgtaagc tgtttatttt     4860

atattaaaat aagcactgtg ctaataacag tgcatattcc tttctatcat ttttgtacag     4920

tttgctgtac tagagatctg gttttgctat tagactgtag gaagagtagc atttcattct     4980

tctctagctg gtggtttcac ggtgccaggt tttctgggtg tccaaaggaa gacgtgtggc     5040

aatagtgggc cctccgacag ccccctctgc cgcctcccca cggccgctcc aggggtggct     5100

ggagacgggt gggcggctgg agaccatgca gagcgccgtg agttctcagg gctcctgcct     5160

tctgtcctgg tgtcacttac tgtttctgtc aggagagcag cggggcgaag cccaggcccc     5220

ttttcactcc ctccatcaag aatggggatc acagagacat tcctccgagc cggggagttt     5280

ctttcctgcc ttcttctttt tgctgttgtt tctaaacaag aatcagtcta tccacagaga     5340

gtcccactgc ctcaggttcc tatggctggc cactgcacag agctctccag ctccaagacc     5400

tgttggttcc aagccctgga gccaactgct gctttttgag gtggcacttt ttcatttgcc     5460

tattcccaca cctccacagt tcagtggcag ggctcaggat ttcgtgggtc tgttttcctt     5520

tctcaccgca gtcgtcgcac agtctctctc tctctctccc ctcaaagtct gcaactttaa     5580

gcagctcttg ctaatcagtg tctcacactg gcgtagaagt ttttgtactg taaagagacc     5640

tacctcaggt tgctggttgc tgtgtggttt ggtgtgttcc cgcaaacccc ctttgtgctg     5700

tggggctggt agctcaggtg ggcgtggtca ctgctgtcat caattgaatg gtcagcgttg     5760

catgtcgtga ccaactagac attctgtcgc cttagcatgt ttgctgaaca ccttgtggaa     5820

gcaaaaatct gaaaatgtga ataaaattat tttggatttt gtaaaaaaaa aa             5872


<210>  3
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Asp Ile Asp Ile Gly Lys Glu Tyr Ile Ile Pro Ser Pro Gly 
1               5                   10                  15      


Tyr Arg Ser Val Arg Glu Arg Thr Ser Thr Ser Gly Thr His Arg Asp 
            20                  25                  30          


Arg Glu Asp Ser Lys Phe Arg Arg Thr Arg Pro Leu Glu Cys Gln Asp 
        35                  40                  45              


Ala Leu Glu Thr Ala Ala Arg Ala Glu Gly Leu Ser Leu Asp Ala Ser 
    50                  55                  60                  


Met His Ser Gln Leu Arg Ile Leu Asp Glu Glu His Pro Lys Gly Lys 
65                  70                  75                  80  


Tyr His His Gly Leu Ser Ala Leu Lys Pro Ile Arg Thr Thr Ser Lys 
                85                  90                  95      


His Gln His Pro Val Asp Asn Ala Gly Leu Phe Ser Cys Met Thr Phe 
            100                 105                 110         


Ser Trp Leu Ser Ser Leu Ala Arg Val Ala His Lys Lys Gly Glu Leu 
        115                 120                 125             


Ser Met Glu Asp Val Trp Ser Leu Ser Lys His Glu Ser Ser Asp Val 
    130                 135                 140                 


Asn Cys Arg Arg Leu Glu Arg Leu Trp Gln Glu Glu Leu Asn Glu Val 
145                 150                 155                 160 


Gly Pro Asp Ala Ala Ser Leu Arg Arg Val Val Trp Ile Phe Cys Arg 
                165                 170                 175     


Thr Arg Leu Ile Leu Ser Ile Val Cys Leu Met Ile Thr Gln Leu Ala 
            180                 185                 190         


Gly Phe Ser Gly Pro Asn Phe Gln Asp Gly Cys Ile Leu Arg Ser Glu 
        195                 200                 205             


<210>  4
<211>  1437
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Asp Ile Asp Ile Gly Lys Glu Tyr Ile Ile Pro Ser Pro Gly 
1               5                   10                  15      


Tyr Arg Ser Val Arg Glu Arg Thr Ser Thr Ser Gly Thr His Arg Asp 
            20                  25                  30          


Arg Glu Asp Ser Lys Phe Arg Arg Thr Arg Pro Leu Glu Cys Gln Asp 
        35                  40                  45              


Ala Leu Glu Thr Ala Ala Arg Ala Glu Gly Leu Ser Leu Asp Ala Ser 
    50                  55                  60                  


Met His Ser Gln Leu Arg Ile Leu Asp Glu Glu His Pro Lys Gly Lys 
65                  70                  75                  80  


Tyr His His Gly Leu Ser Ala Leu Lys Pro Ile Arg Thr Thr Ser Lys 
                85                  90                  95      


His Gln His Pro Val Asp Asn Ala Gly Leu Phe Ser Cys Met Thr Phe 
            100                 105                 110         


Ser Trp Leu Ser Ser Leu Ala Arg Val Ala His Lys Lys Gly Glu Leu 
        115                 120                 125             


Ser Met Glu Asp Val Trp Ser Leu Ser Lys His Glu Ser Ser Asp Val 
    130                 135                 140                 


Asn Cys Arg Arg Leu Glu Arg Leu Trp Gln Glu Glu Leu Asn Glu Val 
145                 150                 155                 160 


Gly Pro Asp Ala Ala Ser Leu Arg Arg Val Val Trp Ile Phe Cys Arg 
                165                 170                 175     


Thr Arg Leu Ile Leu Ser Ile Val Cys Leu Met Ile Thr Gln Leu Ala 
            180                 185                 190         


Gly Phe Ser Gly Pro Ala Phe Met Val Lys His Leu Leu Glu Tyr Thr 
        195                 200                 205             


Gln Ala Thr Glu Ser Asn Leu Gln Tyr Ser Leu Leu Leu Val Leu Gly 
    210                 215                 220                 


Leu Leu Leu Thr Glu Ile Val Arg Ser Trp Ser Leu Ala Leu Thr Trp 
225                 230                 235                 240 


Ala Leu Asn Tyr Arg Thr Gly Val Arg Leu Arg Gly Ala Ile Leu Thr 
                245                 250                 255     


Met Ala Phe Lys Lys Ile Leu Lys Leu Lys Asn Ile Lys Glu Lys Ser 
            260                 265                 270         


Leu Gly Glu Leu Ile Asn Ile Cys Ser Asn Asp Gly Gln Arg Met Phe 
        275                 280                 285             


Glu Ala Ala Ala Val Gly Ser Leu Leu Ala Gly Gly Pro Val Val Ala 
    290                 295                 300                 


Ile Leu Gly Met Ile Tyr Asn Val Ile Ile Leu Gly Pro Thr Gly Phe 
305                 310                 315                 320 


Leu Gly Ser Ala Val Phe Ile Leu Phe Tyr Pro Ala Met Met Phe Ala 
                325                 330                 335     


Ser Arg Leu Thr Ala Tyr Phe Arg Arg Lys Cys Val Ala Ala Thr Asp 
            340                 345                 350         


Glu Arg Val Gln Lys Met Asn Glu Val Leu Thr Tyr Ile Lys Phe Ile 
        355                 360                 365             


Lys Met Tyr Ala Trp Val Lys Ala Phe Ser Gln Ser Val Gln Lys Ile 
    370                 375                 380                 


Arg Glu Glu Glu Arg Arg Ile Leu Glu Lys Ala Gly Tyr Phe Gln Ser 
385                 390                 395                 400 


Ile Thr Val Gly Val Ala Pro Ile Val Val Val Ile Ala Ser Val Val 
                405                 410                 415     


Thr Phe Ser Val His Met Thr Leu Gly Phe Asp Leu Thr Ala Ala Gln 
            420                 425                 430         


Ala Phe Thr Val Val Thr Val Phe Asn Ser Met Thr Phe Ala Leu Lys 
        435                 440                 445             


Val Thr Pro Phe Ser Val Lys Ser Leu Ser Glu Ala Ser Val Ala Val 
    450                 455                 460                 


Asp Arg Phe Lys Ser Leu Phe Leu Met Glu Glu Val His Met Ile Lys 
465                 470                 475                 480 


Asn Lys Pro Ala Ser Pro His Ile Lys Ile Glu Met Lys Asn Ala Thr 
                485                 490                 495     


Leu Ala Trp Asp Ser Ser His Ser Ser Ile Gln Asn Ser Pro Lys Leu 
            500                 505                 510         


Thr Pro Lys Met Lys Lys Asp Lys Arg Ala Ser Arg Gly Lys Lys Glu 
        515                 520                 525             


Lys Val Arg Gln Leu Gln Arg Thr Glu His Gln Ala Val Leu Ala Glu 
    530                 535                 540                 


Gln Lys Gly His Leu Leu Leu Asp Ser Asp Glu Arg Pro Ser Pro Glu 
545                 550                 555                 560 


Glu Glu Glu Gly Lys His Ile His Leu Gly His Leu Arg Leu Gln Arg 
                565                 570                 575     


Thr Leu His Ser Ile Asp Leu Glu Ile Gln Glu Gly Lys Leu Val Gly 
            580                 585                 590         


Ile Cys Gly Ser Val Gly Ser Gly Lys Thr Ser Leu Ile Ser Ala Ile 
        595                 600                 605             


Leu Gly Gln Met Thr Leu Leu Glu Gly Ser Ile Ala Ile Ser Gly Thr 
    610                 615                 620                 


Phe Ala Tyr Val Ala Gln Gln Ala Trp Ile Leu Asn Ala Thr Leu Arg 
625                 630                 635                 640 


Asp Asn Ile Leu Phe Gly Lys Glu Tyr Asp Glu Glu Arg Tyr Asn Ser 
                645                 650                 655     


Val Leu Asn Ser Cys Cys Leu Arg Pro Asp Leu Ala Ile Leu Pro Ser 
            660                 665                 670         


Ser Asp Leu Thr Glu Ile Gly Glu Arg Gly Ala Asn Leu Ser Gly Gly 
        675                 680                 685             


Gln Arg Gln Arg Ile Ser Leu Ala Arg Ala Leu Tyr Ser Asp Arg Ser 
    690                 695                 700                 


Ile Tyr Ile Leu Asp Asp Pro Leu Ser Ala Leu Asp Ala His Val Gly 
705                 710                 715                 720 


Asn His Ile Phe Asn Ser Ala Ile Arg Lys His Leu Lys Ser Lys Thr 
                725                 730                 735     


Val Leu Phe Val Thr His Gln Leu Gln Tyr Leu Val Asp Cys Asp Glu 
            740                 745                 750         


Val Ile Phe Met Lys Glu Gly Cys Ile Thr Glu Arg Gly Thr His Glu 
        755                 760                 765             


Glu Leu Met Asn Leu Asn Gly Asp Tyr Ala Thr Ile Phe Asn Asn Leu 
    770                 775                 780                 


Leu Leu Gly Glu Thr Pro Pro Val Glu Ile Asn Ser Lys Lys Glu Thr 
785                 790                 795                 800 


Ser Gly Ser Gln Lys Lys Ser Gln Asp Lys Gly Pro Lys Thr Gly Ser 
                805                 810                 815     


Val Lys Lys Glu Lys Ala Val Lys Pro Glu Glu Gly Gln Leu Val Gln 
            820                 825                 830         


Leu Glu Glu Lys Gly Gln Gly Ser Val Pro Trp Ser Val Tyr Gly Val 
        835                 840                 845             


Tyr Ile Gln Ala Ala Gly Gly Pro Leu Ala Phe Leu Val Ile Met Ala 
    850                 855                 860                 


Leu Phe Met Leu Asn Val Gly Ser Thr Ala Phe Ser Thr Trp Trp Leu 
865                 870                 875                 880 


Ser Tyr Trp Ile Lys Gln Gly Ser Gly Asn Thr Thr Val Thr Arg Gly 
                885                 890                 895     


Asn Glu Thr Ser Val Ser Asp Ser Met Lys Asp Asn Pro His Met Gln 
            900                 905                 910         


Tyr Tyr Ala Ser Ile Tyr Ala Leu Ser Met Ala Val Met Leu Ile Leu 
        915                 920                 925             


Lys Ala Ile Arg Gly Val Val Phe Val Lys Gly Thr Leu Arg Ala Ser 
    930                 935                 940                 


Ser Arg Leu His Asp Glu Leu Phe Arg Arg Ile Leu Arg Ser Pro Met 
945                 950                 955                 960 


Lys Phe Phe Asp Thr Thr Pro Thr Gly Arg Ile Leu Asn Arg Phe Ser 
                965                 970                 975     


Lys Asp Met Asp Glu Val Asp Val Arg Leu Pro Phe Gln Ala Glu Met 
            980                 985                 990         


Phe Ile Gln Asn Val Ile Leu Val  Phe Phe Cys Val Gly  Met Ile Ala 
        995                 1000                 1005             


Gly Val  Phe Pro Trp Phe Leu  Val Ala Val Gly Pro  Leu Val Ile 
    1010                 1015                 1020             


Leu Phe  Ser Val Leu His Ile  Val Ser Arg Val Leu  Ile Arg Glu 
    1025                 1030                 1035             


Leu Lys  Arg Leu Asp Asn Ile  Thr Gln Ser Pro Phe  Leu Ser His 
    1040                 1045                 1050             


Ile Thr  Ser Ser Ile Gln Gly  Leu Ala Thr Ile His  Ala Tyr Asn 
    1055                 1060                 1065             


Lys Gly  Gln Glu Phe Leu His  Arg Tyr Gln Glu Leu  Leu Asp Asp 
    1070                 1075                 1080             


Asn Gln  Ala Pro Phe Phe Leu  Phe Thr Cys Ala Met  Arg Trp Leu 
    1085                 1090                 1095             


Ala Val  Arg Leu Asp Leu Ile  Ser Ile Ala Leu Ile  Thr Thr Thr 
    1100                 1105                 1110             


Gly Leu  Met Ile Val Leu Met  His Gly Gln Ile Pro  Pro Ala Tyr 
    1115                 1120                 1125             


Ala Gly  Leu Ala Ile Ser Tyr  Ala Val Gln Leu Thr  Gly Leu Phe 
    1130                 1135                 1140             


Gln Phe  Thr Val Arg Leu Ala  Ser Glu Thr Glu Ala  Arg Phe Thr 
    1145                 1150                 1155             


Ser Val  Glu Arg Ile Asn His  Tyr Ile Lys Thr Leu  Ser Leu Glu 
    1160                 1165                 1170             


Ala Pro  Ala Arg Ile Lys Asn  Lys Ala Pro Ser Pro  Asp Trp Pro 
    1175                 1180                 1185             


Gln Glu  Gly Glu Val Thr Phe  Glu Asn Ala Glu Met  Arg Tyr Arg 
    1190                 1195                 1200             


Glu Asn  Leu Pro Leu Val Leu  Lys Lys Val Ser Phe  Thr Ile Lys 
    1205                 1210                 1215             


Pro Lys  Glu Lys Ile Gly Ile  Val Gly Arg Thr Gly  Ser Gly Lys 
    1220                 1225                 1230             


Ser Ser  Leu Gly Met Ala Leu  Phe Arg Leu Val Glu  Leu Ser Gly 
    1235                 1240                 1245             


Gly Cys  Ile Lys Ile Asp Gly  Val Arg Ile Ser Asp  Ile Gly Leu 
    1250                 1255                 1260             


Ala Asp  Leu Arg Ser Lys Leu  Ser Ile Ile Pro Gln  Glu Pro Val 
    1265                 1270                 1275             


Leu Phe  Ser Gly Thr Val Arg  Ser Asn Leu Asp Pro  Phe Asn Gln 
    1280                 1285                 1290             


Tyr Thr  Glu Asp Gln Ile Trp  Asp Ala Leu Glu Arg  Thr His Met 
    1295                 1300                 1305             


Lys Glu  Cys Ile Ala Gln Leu  Pro Leu Lys Leu Glu  Ser Glu Val 
    1310                 1315                 1320             


Met Glu  Asn Gly Asp Asn Phe  Ser Val Gly Glu Arg  Gln Leu Leu 
    1325                 1330                 1335             


Cys Ile  Ala Arg Ala Leu Leu  Arg His Cys Lys Ile  Leu Ile Leu 
    1340                 1345                 1350             


Asp Glu  Ala Thr Ala Ala Met  Asp Thr Glu Thr Asp  Leu Leu Ile 
    1355                 1360                 1365             


Gln Glu  Thr Ile Arg Glu Ala  Phe Ala Asp Cys Thr  Met Leu Thr 
    1370                 1375                 1380             


Ile Ala  His Arg Leu His Thr  Val Leu Gly Ser Asp  Arg Ile Met 
    1385                 1390                 1395             


Val Leu  Ala Gln Gly Gln Val  Val Glu Phe Asp Thr  Pro Ser Val 
    1400                 1405                 1410             


Leu Leu  Ser Asn Asp Ser Ser  Arg Phe Tyr Ala Met  Phe Ala Ala 
    1415                 1420                 1425             


Ala Glu  Asn Lys Val Ala Val  Lys Gly 
    1430                 1435         


<210>  5
<211>  1394
<212>  DNA
<213>  Homo sapiens

<400>  5
agaagtgtca gagtctttgt agctttgaaa gtcacctagg ttatttgggc atgctctcct       60

gagtcctctg ctagttaagc tctctgaaaa gaaggtggca gacccggttt gctgatcgcc      120

ccagggatca ggaggctgat cccaaagttg tcagatggag agtaaataca aggagatact      180

cttgctaaca ggcctggata acatcactga tgaggaactg gataggttta agttctttct      240

ttcagacgag tttaatattg ccacaggcaa actacatact gcaaacagaa tacaagtagc      300

taccttgatg attcaaaatg ctggggcggt gtctgcagtg atgaagacca ttcgtatttt      360

tcagaagttg aattatatgc ttttggcaaa acgtcttcag gaggagaagg agaaagttga      420

taagcaatac aaatcggtaa caaaaccaaa gccactaagt caagctgaaa tgagtcctgc      480

tgcatctgca gccatcagaa atgatgtcgc aaagcaacgt gctgcaccaa aagtctctcc      540

tcatgttaag cctgaacaga aacagatggt ggcccagcag gaatctatca gagaagggtt      600

tcagaagcgc tgtttgccag ttatggtact gaaagcaaag aagcccttca cgtttgagac      660

ccaagaaggc aagcaggaga tgtttcatgc tacagtggct acagaaaagg aattcttctt      720

tgtaaaagtt tttaatacac tgctgaaaga taaattcatt ccaaagagaa taattataat      780

agcaagatat tatcggcaca gtggtttctt agaggtaaat agcgcctcac gtgtgttaga      840

tgctgaatct gaccaaaagg ttaatgtccc gctgaacatt atcagaaaag ctggtgaaac      900

cccgaagatc aacacgcttc aaactcagcc ccttggaaca attgtgaatg gtttgtttgt      960

agtccagaag gtaacagaaa agaagaaaaa catattattt gacctaagtg acaacactgg     1020

gaaaatggaa gtactggggg ttagaaacga ggacacaatg aaatgtaagg aaggagataa     1080

ggttcgactt acattcttca cactgtcaaa aaatggagaa aaactacagc tgacatctgg     1140

agttcatagc accataaagg ttattaaggc caaaaaaaaa acatagagaa gtaaaaagga     1200

ccaattcaag ccaactggtc taagcagcat ttaattgaag aatatgtgat acagcctctt     1260

caatcagatt gtaagttacc tgaaagctgc agttcacagg ctcctctctc caccaaatta     1320

ggatagaata attgctggat aaacaaattc agaatatcaa cagatgatca caataaacat     1380

ctgtttctca ttca                                                       1394


<210>  6
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Ser Lys Tyr Lys Glu Ile Leu Leu Leu Thr Gly Leu Asp Asn 
1               5                   10                  15      


Ile Thr Asp Glu Glu Leu Asp Arg Phe Lys Phe Phe Leu Ser Asp Glu 
            20                  25                  30          


Phe Asn Ile Ala Thr Gly Lys Leu His Thr Ala Asn Arg Ile Gln Val 
        35                  40                  45              


Ala Thr Leu Met Ile Gln Asn Ala Gly Ala Val Ser Ala Val Met Lys 
    50                  55                  60                  


Thr Ile Arg Ile Phe Gln Lys Leu Asn Tyr Met Leu Leu Ala Lys Arg 
65                  70                  75                  80  


Leu Gln Glu Glu Lys Glu Lys Val Asp Lys Gln Tyr Lys Ser Val Thr 
                85                  90                  95      


Lys Pro Lys Pro Leu Ser Gln Ala Glu Met Ser Pro Ala Ala Ser Ala 
            100                 105                 110         


Ala Ile Arg Asn Asp Val Ala Lys Gln Arg Ala Ala Pro Lys Val Ser 
        115                 120                 125             


Pro His Val Lys Pro Glu Gln Lys Gln Met Val Ala Gln Gln Glu Ser 
    130                 135                 140                 


Ile Arg Glu Gly Phe Gln Lys Arg Cys Leu Pro Val Met Val Leu Lys 
145                 150                 155                 160 


Ala Lys Lys Pro Phe Thr Phe Glu Thr Gln Glu Gly Lys Gln Glu Met 
                165                 170                 175     


Phe His Ala Thr Val Ala Thr Glu Lys Glu Phe Phe Phe Val Lys Val 
            180                 185                 190         


Phe Asn Thr Leu Leu Lys Asp Lys Phe Ile Pro Lys Arg Ile Ile Ile 
        195                 200                 205             


Ile Ala Arg Tyr Tyr Arg His Ser Gly Phe Leu Glu Val Asn Ser Ala 
    210                 215                 220                 


Ser Arg Val Leu Asp Ala Glu Ser Asp Gln Lys Val Asn Val Pro Leu 
225                 230                 235                 240 


Asn Ile Ile Arg Lys Ala Gly Glu Thr Pro Lys Ile Asn Thr Leu Gln 
                245                 250                 255     


Thr Gln Pro Leu Gly Thr Ile Val Asn Gly Leu Phe Val Val Gln Lys 
            260                 265                 270         


Val Thr Glu Lys Lys Lys Asn Ile Leu Phe Asp Leu Ser Asp Asn Thr 
        275                 280                 285             


Gly Lys Met Glu Val Leu Gly Val Arg Asn Glu Asp Thr Met Lys Cys 
    290                 295                 300                 


Lys Glu Gly Asp Lys Val Arg Leu Thr Phe Phe Thr Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Glu Lys Leu Gln Leu Thr Ser Gly Val His Ser Thr Ile Lys Val 
                325                 330                 335     


Ile Lys Ala Lys Lys Lys Thr 
            340             


<210>  7
<211>  1358
<212>  DNA
<213>  Homo sapiens

<400>  7
gttggtgaag atcttaacac cacgccttga gcaagtcgca agagcgggag gacacagacc       60

aggaaccgag aagggacaag cacatggaag ccagcccagc atccgggccc agacacttga      120

tggatccaca catattcact tccaacttta acaatggcat tggaaggcat aagacctacc      180

tgtgctacga agtggagcgc ctggacaatg gcacctcggt caagatggac cagcacaggg      240

gctttctaca caaccaggct aagaatcttc tctgtggctt ttacggccgc catgcggagc      300

tgcgcttctt ggacctggtt ccttctttgc agttggaccc ggcccagatc tacagggtca      360

cttggttcat ctcctggagc ccctgcttct cctggggctg tgccggggaa gtgcgtgcgt      420

tccttcagga gaacacacac gtgagactgc gtatcttcgc tgcccgcatc tatgattacg      480

accccctata taaggaggca ctgcaaatgc tgcgggatgc tggggcccaa gtctccatca      540

tgacctacga tgaatttaag cactgctggg acacctttgt ggaccaccag ggatgtccct      600

tccagccctg ggatggacta gatgagcaca gccaagccct gagtgggagg ctgcgggcca      660

ttctccagaa tcagggaaac tgaaggatgg gcctcagtct ctaaggaagg cagagacctg      720

ggttgagcag cagaataaaa gatcttcttc caagaaatgc aaacagaccg ttcaccacca      780

tctccagctg ctcacagacg ccagcaaagc agtatgctcc cgatcaagta gatttttaaa      840

aaatcagagt gggccgggcg cggtggctca cgcctgtaat cccagcactt tggaggccaa      900

ggcgggtgga tcacgaggtc aggagatcga gaccatcctg gctaacacgg tgaaaccctg      960

tctctactaa aaatacaaaa aattagccag gcgtggtggc gggcgcctgt agtcccagct     1020

actctggagg ctgaggcagg agagtagcgt gaacccggga ggcagagctt gcggtgagcc     1080

gagattgcgc tactgcactc cagcctgggc gacagtacca gactccatct caaaaaaaaa     1140

aaaaccagac tgaattaatt ttaactgaaa atttctctta tgttccaagt acacaatagt     1200

aagattatgc tcaatattct cagaataatt ttcaatgtat taatgaaatg aaatgataat     1260

ttggcttcat atctagacta acacaaaatt aagaatcttc cataattgct tttgctcagt     1320

aactgtgtca tgaattgcaa gagtttccac aaacacta                             1358


<210>  8
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  9
<211>  1565
<212>  DNA
<213>  Homo sapiens

<400>  9
agtctcactt cagttccttt tgcatgaaga gctcagaatc aaaagaggaa accaacccct       60

aagatgagct ttccatgtaa atttgtagcc agcttccttc tgattttcaa tgtttcttcc      120

aaaggtgcag tctccaaaga gattacgaat gccttggaaa cctggggtgc cttgggtcag      180

gacatcaact tggacattcc tagttttcaa atgagtgatg atattgacga tataaaatgg      240

gaaaaaactt cagacaagaa aaagattgca caattcagaa aagagaaaga gactttcaag      300

gaaaaagata catataagct atttaaaaat ggaactctga aaattaagca tctgaagacc      360

gatgatcagg atatctacaa ggtatcaata tatgatacaa aaggaaaaaa tgtgttggaa      420

aaaatatttg atttgaagat tcaagagagg gtctcaaaac caaagatctc ctggacttgt      480

atcaacacaa ccctgacctg tgaggtaatg aatggaactg accccgaatt aaacctgtat      540

caagatggga aacatctaaa actttctcag agggtcatca cacacaagtg gaccaccagc      600

ctgagtgcaa aattcaagtg cacagcaggg aacaaagtca gcaaggaatc cagtgtcgag      660

cctgtcagct gtccagagaa aggtctggac atctatctca tcattggcat atgtggagga      720

ggcagcctct tgatggtctt tgtggcactg ctcgttttct atatcaccaa aaggaaaaaa      780

cagaggagtc ggagaaatga tgaggagctg gagacaagag cccacagagt agctactgaa      840

gaaaggggcc ggaagcccca ccaaattcca gcttcaaccc ctcagaatcc agcaacttcc      900

caacatcctc ctccaccacc tggtcatcgt tcccaggcac ctagtcatcg tcccccgcct      960

cctggacacc gtgttcagca ccagcctcag aagaggcctc ctgctccgtc gggcacacaa     1020

gttcaccagc agaaaggccc gcccctcccc agacctcgag ttcagccaaa acctccccat     1080

ggggcagcag aaaactcatt gtccccttcc tctaattaaa aaagatagaa actgtctttt     1140

tcaataaaaa gcactgtgga tttctgccct cctgatgtgc atatccgtac ttccatgagg     1200

tgttttctgt gtgcagaaca ttgtcacctc ctgaggctgt gggccacagc cacctctgca     1260

tcttcgaact cagccatgtg gtcaacatct ggagtttttg gtctcctcag agagctccat     1320

cacaccagta aggagaagca atataagtgt gattgcaaga atggtagagg accgagcaca     1380

gaaatcttag agatttcttg tcccctctca ggtcatgtgt agatgcgata aatcaagtga     1440

ttggtgtgcc tgggtctcac tacaagcagc ctatctgctt aagagactct ggagtttctt     1500

atgtgccctg gtggacactt gcccaccatc ctgtgagtaa aagtgaaata aaagctttga     1560

ctaga                                                                 1565


<210>  10
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  11
<211>  1674
<212>  DNA
<213>  Homo sapiens

<400>  11
gtcctccact tcctggggag gtagctgcag aataaaacca gcagagactc cttttctcct       60

aaccgtcccg gccaccgctg cctcagcctc tgcctcccag cctctttctg agggaaagga      120

caagatgaag tggaaggcgc ttttcaccgc ggccatcctg caggcacagt tgccgattac      180

agaggcacag agctttggcc tgctggatcc caaactctgc tacctgctgg atggaatcct      240

cttcatctat ggtgtcattc tcactgcctt gttcctgaga gtgaagttca gcaggagcgc      300

agacgccccc gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg      360

aagagaggag tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa      420

gccgagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc      480

ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg      540

cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc      600

cctgccccct cgctaacagc caggggattt caccactcaa aggccagacc tgcagacgcc      660

cagattatga gacacaggat gaagcattta caacccggtt cactcttctc agccactgaa      720

gtattcccct ttatgtacag gatgctttgg ttatatttag ctccaaacct tcacacacag      780

actgttgtcc ctgcactctt taagggagtg tactcccagg gcttacggcc ctggccttgg      840

gccctctggt ttgccggtgg tgcaggtaga cctgtctcct ggcggttcct cgttctccct      900

gggaggcggg cgcactgcct ctcacagctg agttgttgag tctgttttgt aaagtcccca      960

gagaaagcgc agatgctagc acatgcccta atgtctgtat cactctgtgt ctgagtggct     1020

tcactcctgc tgtaaatttg gcttctgttg tcaccttcac ctcctttcaa ggtaactgta     1080

ctgggccatg ttgtgcctcc ctggtgagag ggccgggcag aggggcagat ggaaaggagc     1140

ctaggccagg tgcaaccagg gagctgcagg ggcatgggaa ggtgggcggg caggggaggg     1200

tcagccaggg cctgcgaggg cagcgggagc ctccctgcct caggcctctg tgccgcacca     1260

ttgaactgta ccatgtgcta caggggccag aagatgaaca gactgacctt gatgagctgt     1320

gcacaaagtg gcataaaaaa catgtggtta cacagtgtga ataaagtgct gcggagcaag     1380

aggaggccgt tgattcactt cacgctttca gcgaatgaca aaatcatctt tgtgaaggcc     1440

tcgcaggaag acccaacaca tgggacctat aactgcccag cggacagtgg caggacagga     1500

aaaacccgtc aatgtactag gatactgctg cgtcattaca gggcacaggc catggatgga     1560

aaacgctctc tgctctgctt tttttctact gttttaattt atactggcat gctaaagcct     1620

tcctattttg cataataaat gcttcagtga aaaaaaaaaa aaaaaaaaaa aaaa           1674


<210>  12
<211>  1690
<212>  DNA
<213>  Homo sapiens

<400>  12
tgctttctca aaggccccac agtcctccac ttcctgggga ggtagctgca gaataaaacc       60

agcagagact ccttttctcc taaccgtccc ggccaccgct gcctcagcct ctgcctccca      120

gcctctttct gagggaaagg acaagatgaa gtggaaggcg cttttcaccg cggccatcct      180

gcaggcacag ttgccgatta cagaggcaca gagctttggc ctgctggatc ccaaactctg      240

ctacctgctg gatggaatcc tcttcatcta tggtgtcatt ctcactgcct tgttcctgag      300

agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta      360

taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg      420

ggaccctgag atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa      480

tgaactgcag aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg      540

ccggaggggc aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac      600

ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa cagccagggg atttcaccac      660

tcaaaggcca gacctgcaga cgcccagatt atgagacaca ggatgaagca tttacaaccc      720

ggttcactct tctcagccac tgaagtattc ccctttatgt acaggatgct ttggttatat      780

ttagctccaa accttcacac acagactgtt gtccctgcac tctttaaggg agtgtactcc      840

cagggcttac ggccctggcc ttgggccctc tggtttgccg gtggtgcagg tagacctgtc      900

tcctggcggt tcctcgttct ccctgggagg cgggcgcact gcctctcaca gctgagttgt      960

tgagtctgtt ttgtaaagtc cccagagaaa gcgcagatgc tagcacatgc cctaatgtct     1020

gtatcactct gtgtctgagt ggcttcactc ctgctgtaaa tttggcttct gttgtcacct     1080

tcacctcctt tcaaggtaac tgtactgggc catgttgtgc ctccctggtg agagggccgg     1140

gcagaggggc agatggaaag gagcctaggc caggtgcaac cagggagctg caggggcatg     1200

ggaaggtggg cgggcagggg agggtcagcc agggcctgcg agggcagcgg gagcctccct     1260

gcctcaggcc tctgtgccgc accattgaac tgtaccatgt gctacagggg ccagaagatg     1320

aacagactga ccttgatgag ctgtgcacaa agtggcataa aaaacatgtg gttacacagt     1380

gtgaataaag tgctgcggag caagaggagg ccgttgattc acttcacgct ttcagcgaat     1440

gacaaaatca tctttgtgaa ggcctcgcag gaagacccaa cacatgggac ctataactgc     1500

ccagcggaca gtggcaggac aggaaaaacc cgtcaatgta ctaggatact gctgcgtcat     1560

tacagggcac aggccatgga tggaaaacgc tctctgctct gctttttttc tactgtttta     1620

atttatactg gcatgctaaa gccttcctat tttgcataat aaatgcttca gtgaaaatgc     1680

aaaaaaaaaa                                                            1690


<210>  13
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  14
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  15
<211>  4721
<212>  DNA
<213>  Homo sapiens

<400>  15
acacttcggg ttcctcgggg aggaggggct ggaaccctag cccatcgtca ggacaaagat       60

gctcaggctg ctcttggctc tcaacttatt cccttcaatt caagtaacag gaaacaagat      120

tttggtgaag cagtcgccca tgcttgtagc gtacgacaat gcggtcaacc ttagctgcaa      180

gtattcctac aatctcttct caagggagtt ccgggcatcc cttcacaaag gactggatag      240

tgctgtggaa gtctgtgttg tatatgggaa ttactcccag cagcttcagg tttactcaaa      300

aacggggttc aactgtgatg ggaaattggg caatgaatca gtgacattct acctccagaa      360

tttgtatgtt aaccaaacag atatttactt ctgcaaaatt gaagttatgt atcctcctcc      420

ttacctagac aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg      480

tccaagtccc ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg      540

agtcctggct tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag      600

taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc      660

cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctcctg      720

acacggacgc ctatccagaa gccagccggc tggcagcccc catctgctca atatcactgc      780

tctggatagg aaatgaccgc catctccagc cggccacctc aggcccctgt tgggccacca      840

atgccaattt ttctcgagtg actagaccaa atatcaagat cattttgaga ctctgaaatg      900

aagtaaaaga gatttcctgt gacaggccaa gtcttacagt gccatggccc acattccaac      960

ttaccatgta cttagtgact tgactgagaa gttagggtag aaaacaaaaa gggagtggat     1020

tctgggagcc tcttcccttt ctcactcacc tgcacatctc agtcaagcaa agtgtggtat     1080

ccacagacat tttagttgca gaagaaaggc taggaaatca ttccttttgg ttaaatgggt     1140

gtttaatctt ttggttagtg ggttaaacgg ggtaagttag agtaggggga gggataggaa     1200

gacatattta aaaaccatta aaacactgtc tcccactcat gaaatgagcc acgtagttcc     1260

tatttaatgc tgttttcctt tagtttagaa atacatagac attgtctttt atgaattctg     1320

atcatattta gtcattttga ccaaatgagg gatttggtca aatgagggat tccctcaaag     1380

caatatcagg taaaccaagt tgctttcctc actccctgtc atgagacttc agtgttaatg     1440

ttcacaatat actttcgaaa gaataaaata gttctcctac atgaagaaag aatatgtcag     1500

gaaataaggt cactttatgt caaaattatt tgagtactat gggacctggc gcagtggctc     1560

atgcttgtaa tcccagcact ttgggaggcc gaggtgggca gatcacttga gatcaggacc     1620

agcctggtca agatggtgaa actccgtctg tactaaaaat acaaaattta gcttggcctg     1680

gtggcaggca cctgtaatcc cagctgccca agaggctgag gcatgagaat cgcttgaacc     1740

tggcaggcgg aggttgcagt gagccgagat agtgccacag ctctccagcc tgggcgacag     1800

agtgagactc catctcaaac aacaacaaca acaacaacaa caacaacaaa ccacaaaatt     1860

atttgagtac tgtgaaggat tatttgtcta acagttcatt ccaatcagac caggtaggag     1920

ctttcctgtt tcatatgttt cagggttgca cagttggtct ctttaatgtc ggtgtggaga     1980

tccaaagtgg gttgtggaaa gagcgtccat aggagaagtg agaatactgt gaaaaaggga     2040

tgttagcatt cattagagta tgaggatgag tcccaagaag gttctttgga aggaggacga     2100

atagaatgga gtaatgaaat tcttgccatg tgctgaggag atagccagca ttaggtgaca     2160

atcttccaga agtggtcagg cagaaggtgc cctggtgaga gctcctttac agggacttta     2220

tgtggtttag ggctcagagc tccaaaactc tgggctcagc tgctcctgta ccttggaggt     2280

ccattcacat gggaaagtat tttggaatgt gtcttttgaa gagagcatca gagttcttaa     2340

gggactgggt aaggcctgac cctgaaatga ccatggatat ttttctacct acagtttgag     2400

tcaactagaa tatgcctggg gaccttgaag aatggccctt cagtggccct caccatttgt     2460

tcatgcttca gttaattcag gtgttgaagg agcttaggtt ttagaggcac gtagacttgg     2520

ttcaagtctc gttagtagtt gaatagcctc aggcaagtca ctgcccacct aagatgatgg     2580

ttcttcaact ataaaatgga gataatggtt acaaatgtct cttcctatag tataatctcc     2640

ataagggcat ggcccaagtc tgtctttgac tctgcctatc cctgacattt agtagcatgc     2700

ccgacataca atgttagcta ttggtattat tgccatatag ataaattatg tataaaaatt     2760

aaactgggca atagcctaag aaggggggaa tattgtaaca caaatttaaa cccactacgc     2820

agggatgagg tgctataata tgaggacctt ttaacttcca tcattttcct gtttcttgaa     2880

atagtttatc ttgtaatgaa atataaggca cctcccactt ttatgtatag aaagaggtct     2940

tttaattttt ttttaatgtg agaaggaagg gaggagtagg aatcttgaga ttccagatcg     3000

aaaatactgt actttggttg atttttaagt gggcttccat tccatggatt taatcagtcc     3060

caagaagatc aaactcagca gtacttgggt gctgaagaac tgttggattt accctggcac     3120

gtgtgccact tgccagcttc ttgggcacac agagttcttc aatccaagtt atcagattgt     3180

atttgaaaat gacagagctg gagagttttt tgaaatggca gtggcaaata aataaatact     3240

tttttttaaa tggaaagact tgatctatgg taataaatga ttttgttttc tgactggaaa     3300

aataggccta ctaaagatga atcacacttg agatgtttct tactcactct gcacagaaac     3360

aaagaagaaa tgttatacag ggaagtccgt tttcactatt agtatgaacc aagaaatggt     3420

tcaaaaacag tggtaggagc aatgctttca tagtttcaga tatggtagtt atgaagaaaa     3480

caatgtcatt tgctgctatt attgtaagag tcttataatt aatggtactc ctataatttt     3540

tgattgtgag ctcacctatt tgggttaagc atgccaattt aaagagacca agtgtatgta     3600

cattatgttc tacatattca gtgataaaat tactaaacta ctatatgtct gctttaaatt     3660

tgtactttaa tattgtcttt tggtattaag aaagatatgc tttcagaata gatatgcttc     3720

gctttggcaa ggaatttgga tagaacttgc tatttaaaag aggtgtgggg taaatccttg     3780

tataaatctc cagtttagcc ttttttgaaa aagctagact ttcaaatact aatttcactt     3840

caagcagggt acgtttctgg tttgtttgct tgacttcagt cacaatttct tatcagacca     3900

atggctgacc tctttgagat gtcaggctag gcttacctat gtgttctgtg tcatgtgaat     3960

gctgagaagt ttgacagaga tccaacttca gccttgaccc catcagtccc tcgggttaac     4020

taactgagcc accggtcctc atggctattt taatgagggt attgatggtt aaatgcatgt     4080

ctgatccctt atcccagcca tttgcactgc cagctgggaa ctataccaga cctggatact     4140

gatcccaaag tgttaaattc aactacatgc tggagattag agatggtgcc aataaaggac     4200

ccagaaccag gatcttgatt gctatagact tattaataat ccaggtcaaa gagagtgaca     4260

cacactctct caagacctgg ggtgagggag tctgtgttat ctgcaaggcc atttgaggct     4320

cagaaagtct ctctttccta tagatatatg catactttct gacatatagg aatgtatcag     4380

gaatactcaa ccatcacagg catgttccta cctcagggcc tttacatgtc ctgtttactc     4440

tgtctagaat gtccttctgt agatgacctg gcttgcctcg tcacccttca ggtccttgct     4500

caagtgtcat cttctcccct agttaaacta ccccacaccc tgtctgcttt ccttgcttat     4560

ttttctccat agcattttac catctcttac attagacatt tttcttattt atttgtagtt     4620

tataagcttc atgaggcaag taactttgct ttgtttcttg ctgtatctcc agtgcccaga     4680

gcagtgcctg gtatataata aatatttatt gactgagtga a                         4721


<210>  16
<211>  4543
<212>  DNA
<213>  Homo sapiens

<400>  16
taaagtcatc aaaacaacgt tatatcctgt gtgaaatgct gcagtcagga tgccttgtgg       60

tttgagtgcc ttgatcatgt gccctaaggg gatggtggcg gtggtggtgg ccgtggatga      120

cggagactct caggccttgg caggtgcgtc tttcagttcc cctcacactt cgggttcctc      180

ggggaggagg ggctggaacc ctagcccatc gtcaggacaa agatgctcag gctgctcttg      240

gctctcaact tattcccttc aattcaagta acagggaaac acctttgtcc aagtccccta      300

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      360

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      420

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      480

taccagccct atgccccacc acgcgacttc gcagcctatc gctcctgaca cggacgccta      540

tccagaagcc agccggctgg cagcccccat ctgctcaata tcactgctct ggataggaaa      600

tgaccgccat ctccagccgg ccacctcagg cccctgttgg gccaccaatg ccaatttttc      660

tcgagtgact agaccaaata tcaagatcat tttgagactc tgaaatgaag taaaagagat      720

ttcctgtgac aggccaagtc ttacagtgcc atggcccaca ttccaactta ccatgtactt      780

agtgacttga ctgagaagtt agggtagaaa acaaaaaggg agtggattct gggagcctct      840

tccctttctc actcacctgc acatctcagt caagcaaagt gtggtatcca cagacatttt      900

agttgcagaa gaaaggctag gaaatcattc cttttggtta aatgggtgtt taatcttttg      960

gttagtgggt taaacggggt aagttagagt agggggaggg ataggaagac atatttaaaa     1020

accattaaaa cactgtctcc cactcatgaa atgagccacg tagttcctat ttaatgctgt     1080

tttcctttag tttagaaata catagacatt gtcttttatg aattctgatc atatttagtc     1140

attttgacca aatgagggat ttggtcaaat gagggattcc ctcaaagcaa tatcaggtaa     1200

accaagttgc tttcctcact ccctgtcatg agacttcagt gttaatgttc acaatatact     1260

ttcgaaagaa taaaatagtt ctcctacatg aagaaagaat atgtcaggaa ataaggtcac     1320

tttatgtcaa aattatttga gtactatggg acctggcgca gtggctcatg cttgtaatcc     1380

cagcactttg ggaggccgag gtgggcagat cacttgagat caggaccagc ctggtcaaga     1440

tggtgaaact ccgtctgtac taaaaataca aaatttagct tggcctggtg gcaggcacct     1500

gtaatcccag ctgcccaaga ggctgaggca tgagaatcgc ttgaacctgg caggcggagg     1560

ttgcagtgag ccgagatagt gccacagctc tccagcctgg gcgacagagt gagactccat     1620

ctcaaacaac aacaacaaca acaacaacaa caacaaacca caaaattatt tgagtactgt     1680

gaaggattat ttgtctaaca gttcattcca atcagaccag gtaggagctt tcctgtttca     1740

tatgtttcag ggttgcacag ttggtctctt taatgtcggt gtggagatcc aaagtgggtt     1800

gtggaaagag cgtccatagg agaagtgaga atactgtgaa aaagggatgt tagcattcat     1860

tagagtatga ggatgagtcc caagaaggtt ctttggaagg aggacgaata gaatggagta     1920

atgaaattct tgccatgtgc tgaggagata gccagcatta ggtgacaatc ttccagaagt     1980

ggtcaggcag aaggtgccct ggtgagagct cctttacagg gactttatgt ggtttagggc     2040

tcagagctcc aaaactctgg gctcagctgc tcctgtacct tggaggtcca ttcacatggg     2100

aaagtatttt ggaatgtgtc ttttgaagag agcatcagag ttcttaaggg actgggtaag     2160

gcctgaccct gaaatgacca tggatatttt tctacctaca gtttgagtca actagaatat     2220

gcctggggac cttgaagaat ggcccttcag tggccctcac catttgttca tgcttcagtt     2280

aattcaggtg ttgaaggagc ttaggtttta gaggcacgta gacttggttc aagtctcgtt     2340

agtagttgaa tagcctcagg caagtcactg cccacctaag atgatggttc ttcaactata     2400

aaatggagat aatggttaca aatgtctctt cctatagtat aatctccata agggcatggc     2460

ccaagtctgt ctttgactct gcctatccct gacatttagt agcatgcccg acatacaatg     2520

ttagctattg gtattattgc catatagata aattatgtat aaaaattaaa ctgggcaata     2580

gcctaagaag gggggaatat tgtaacacaa atttaaaccc actacgcagg gatgaggtgc     2640

tataatatga ggacctttta acttccatca ttttcctgtt tcttgaaata gtttatcttg     2700

taatgaaata taaggcacct cccactttta tgtatagaaa gaggtctttt aatttttttt     2760

taatgtgaga aggaagggag gagtaggaat cttgagattc cagatcgaaa atactgtact     2820

ttggttgatt tttaagtggg cttccattcc atggatttaa tcagtcccaa gaagatcaaa     2880

ctcagcagta cttgggtgct gaagaactgt tggatttacc ctggcacgtg tgccacttgc     2940

cagcttcttg ggcacacaga gttcttcaat ccaagttatc agattgtatt tgaaaatgac     3000

agagctggag agttttttga aatggcagtg gcaaataaat aaatactttt ttttaaatgg     3060

aaagacttga tctatggtaa taaatgattt tgttttctga ctggaaaaat aggcctacta     3120

aagatgaatc acacttgaga tgtttcttac tcactctgca cagaaacaaa gaagaaatgt     3180

tatacaggga agtccgtttt cactattagt atgaaccaag aaatggttca aaaacagtgg     3240

taggagcaat gctttcatag tttcagatat ggtagttatg aagaaaacaa tgtcatttgc     3300

tgctattatt gtaagagtct tataattaat ggtactccta taatttttga ttgtgagctc     3360

acctatttgg gttaagcatg ccaatttaaa gagaccaagt gtatgtacat tatgttctac     3420

atattcagtg ataaaattac taaactacta tatgtctgct ttaaatttgt actttaatat     3480

tgtcttttgg tattaagaaa gatatgcttt cagaatagat atgcttcgct ttggcaagga     3540

atttggatag aacttgctat ttaaaagagg tgtggggtaa atccttgtat aaatctccag     3600

tttagccttt tttgaaaaag ctagactttc aaatactaat ttcacttcaa gcagggtacg     3660

tttctggttt gtttgcttga cttcagtcac aatttcttat cagaccaatg gctgacctct     3720

ttgagatgtc aggctaggct tacctatgtg ttctgtgtca tgtgaatgct gagaagtttg     3780

acagagatcc aacttcagcc ttgaccccat cagtccctcg ggttaactaa ctgagccacc     3840

ggtcctcatg gctattttaa tgagggtatt gatggttaaa tgcatgtctg atcccttatc     3900

ccagccattt gcactgccag ctgggaacta taccagacct ggatactgat cccaaagtgt     3960

taaattcaac tacatgctgg agattagaga tggtgccaat aaaggaccca gaaccaggat     4020

cttgattgct atagacttat taataatcca ggtcaaagag agtgacacac actctctcaa     4080

gacctggggt gagggagtct gtgttatctg caaggccatt tgaggctcag aaagtctctc     4140

tttcctatag atatatgcat actttctgac atataggaat gtatcaggaa tactcaacca     4200

tcacaggcat gttcctacct cagggccttt acatgtcctg tttactctgt ctagaatgtc     4260

cttctgtaga tgacctggct tgcctcgtca cccttcaggt ccttgctcaa gtgtcatctt     4320

ctcccctagt taaactaccc cacaccctgt ctgctttcct tgcttatttt tctccatagc     4380

attttaccat ctcttacatt agacattttt cttatttatt tgtagtttat aagcttcatg     4440

aggcaagtaa ctttgctttg tttcttgctg tatctccagt gcccagagca gtgcctggta     4500

tataataaat atttattgac tgagtgaaaa aaaaaaaaaa aaa                       4543


<210>  17
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  18
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  19
<211>  1534
<212>  DNA
<213>  Homo sapiens

<400>  19
tattgtcaga gtcctcttgt ttggccttct aggaaggctg tgggacccag ctttcttcaa       60

ccagtccagg tggaggcctc tgccttgaac gtttccaagt gaggtaaaac ccgcaggccc      120

agaggcctct ctacttcctg tgtggggttc agaaaccctc ctcccctccc agcctcaggt      180

gcctgcttca gaaaatgaag tagtaagtct gctggcctcc gccatcttag taaagtaaca      240

gtcccatgaa acaaagatgc agtcgggcac tcactggaga gttctgggcc tctgcctctt      300

atcagttggc gtttgggggc aagatggtaa tgaagaaatg ggtggtatta cacagacacc      360

atataaagtc tccatctctg gaaccacagt aatattgaca tgccctcagt atcctggatc      420

tgaaatacta tggcaacaca atgataaaaa cataggcggt gatgaggatg ataaaaacat      480

aggcagtgat gaggatcacc tgtcactgaa ggaattttca gaattggagc aaagtggtta      540

ttatgtctgc taccccagag gaagcaaacc agaagatgcg aacttttatc tctacctgag      600

ggcaagagtg tgtgagaact gcatggagat ggatgtgatg tcggtggcca caattgtcat      660

agtggacatc tgcatcactg ggggcttgct gctgctggtt tactactgga gcaagaatag      720

aaaggccaag gccaagcctg tgacacgagg agcgggtgct ggcggcaggc aaaggggaca      780

aaacaaggag aggccaccac ctgttcccaa cccagactat gagcccatcc ggaaaggcca      840

gcgggacctg tattctggcc tgaatcagag acgcatctga ccctctggag aacactgcct      900

cccgctggcc caggtctcct ctccagtccc cctgcgactc cctgtttcct gggctagtct      960

tggaccccac gagagagaat cgttcctcag cctcatggtg aactcgcgcc ctccagcctg     1020

atcccccgct ccctcctccc tgccttctct gctggtaccc agtcctaaaa tattgctgct     1080

tcctcttcct ttgaagcatc atcagtagtc acaccctcac agctggcctg ccctcttgcc     1140

aggatattta tttgtgctat tcactccctt ccctttggat gtaacttctc cgttcagttc     1200

cctccttttc ttgcatgtaa gttgtccccc atcccaaagt attccatcta cttttctatc     1260

gccgtcccct tttgcagccc tctctgggga tggactgggt aaatgttgac agaggccctg     1320

ccccgttcac agatcctggc cctgagccag ccctgtgctc ctccctcccc caacactccc     1380

taccaacccc ctaatcccct actccctcca ccccccctcc actgtaggcc actggatggt     1440

catttgcatc tccgtaaatg tgctctgctc ctcagctgag agagaaaaaa ataaactgta     1500

tttggctgca agaaaaaaaa aaaaaaaaaa aaaa                                 1534


<210>  20
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  21
<211>  2690
<212>  DNA
<213>  Homo sapiens

<400>  21
agtctagctg ctgcacaggc tggctggctg gctggctgct aagggctgct ccacgctttt       60

gccggaggac agagactgac atggaacagg ggaagggcct ggctgtcctc atcctggcta      120

tcattcttct tcaaggtact ttggcccagt caatcaaagg aaaccacttg gttaaggtgt      180

atgactatca agaagatggt tcggtacttc tgacttgtga tgcagaagcc aaaaatatca      240

catggtttaa agatgggaag atgatcggct tcctaactga agataaaaaa aaatggaatc      300

tgggaagtaa tgccaaggac cctcgaggga tgtatcagtg taaaggatca cagaacaagt      360

caaaaccact ccaagtgtat tacagaatgt gtcagaactg cattgaacta aatgcagcca      420

ccatatctgg ctttctcttt gctgaaatcg tcagcatttt cgtccttgct gttggggtct      480

acttcattgc tggacaggat ggagttcgcc agtcgagagc ttcagacaag cagactctgt      540

tgcccaatga ccagctctac cagcccctca aggatcgaga agatgaccag tacagccacc      600

ttcaaggaaa ccagttgagg aggaattgaa ctcaggactc agagtagtcc aggtgttctc      660

ctcctattca gttcccagaa tcaaagcaat gcattttgga aagctcctag cagagagact      720

ttcagcccta aatctagact caaggttccc agagatgaca aatggagaag aaaggccatc      780

agagcaaatt tgggggtttc tcaaataaaa taaaaataaa aacaaatact gtgtttcaga      840

agcgccacct attggggaaa attgtaaaag aaaaatgaaa agatcaaata accccctgga      900

tttgaatata attttttgtg ttgtaatttt tatttcgttt ttgtataggt tataattcac      960

atggctcaaa tattcagtga aagctctccc tccaccgcca tcccctgcta cccagtgacc     1020

ctgttgccct cttcagagac aaattagttt ctcttttttt tttttttttt tttttttttg     1080

agacagtctg gctctgtcac ccaggctgaa atgcagtggc accatctcgg ctcactgcaa     1140

cctctgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgggcag ctgggattac     1200

aggcacacac taccacacct ggctaatttt tgtattttta gtagagacag ggttttgctc     1260

tgttggccaa gctggtctcg aactcctgac ctcaagtgat ccgcccgcct cagcctccca     1320

aagtgctggg attacaggtg tgagccacca tgcctggtct taaaaccagt ttcttatata     1380

tctctctgga ggtattctag gcatatatga gcacattctc aagtacatat tatcctccct     1440

tcccctatct tttagacaaa tgatatcaaa ctatacatct tgtgagatta ttgcatacca     1500

ttatatgaag ataccattat atccttttta atgcaaccat attgtacaaa tagactatga     1560

tttatttaac ctgttatcta tcagtggata tttaagttgg tagttggttc caatcttttg     1620

ctcttacaac aattctgcaa tgactaacat tgtataaata tcatttttaa aaataattgc     1680

attgaagcat aatgtacatg ccataaaatc cacccatctt aagtgatttc acctgttctc     1740

agaaattttt agtaaattta actaattgta cagccattac cataatccag ctttaggaca     1800

ttttcttttt tttcttttct tttctttttt ttcttttttt tttttttttg aagtggaatc     1860

ttgctctgtg gcccaggctg gagtgcagtg gcgcgatctc agctcactgc aacctccacc     1920

tcctgggttc aagcgattct cttgccttgg cctcccgagt agctgagact acaggcacat     1980

gccaccacgc ccagctcatt ttttgtgtat ttagtatttg tgtatctagt atttgtgtac     2040

ttagtagaga cagggtttca ccatgttggc caggctggtc tccaattcct gacctcaggc     2100

gatccacccg ccttgacctc ccaaagtgct gggattacag gtgtgagcca ccgcgccagg     2160

cccgtaactg tattttaata tagccattct atggatttaa tatggtattt tattatggcc     2220

ttaatttgca tttccctaga tactaaccat gctgagtgtc ctgtcttgtg tttattaacc     2280

attcatatat ttttagtgaa atgtgtatca aatcttttgc ccatttttaa gttgacttat     2340

ttgtttgtct tcttactatt gggttgcata tgtttttgat ataagtcctt tatcagatat     2400

atgatttgga aatattttct accaatctgt ggtttgtttt tcttaatggt gtcttttgaa     2460

gtgcaaaagg tttgaatttt gaagtacatt ttattgattt tttcttctat atattgtgct     2520

tttggtatca tgtctaataa atctttacca aacccacagt tacaaagatt ttctcctgtc     2580

ttctttttat actttttaca gctttatggt tttagctcta acaataaatg tgattttgaa     2640

catacataag actatttgta acaaacacaa ataaattgaa ttgttgggca                2690


<210>  22
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  23
<211>  3049
<212>  DNA
<213>  Homo sapiens

<400>  23
ctctcttcat ttaagcacga ctctgcagaa ggaacaaagc accctcccca ctgggctcct       60

ggttgcagag ctccaagtcc tcacacagat acgcctgttt gagaagcagc gggcaagaaa      120

gacgcaagcc cagaggccct gccatttctg tgggctcagg tccctactgg ctcaggcccc      180

tgcctccctc ggcaaggcca caatgaaccg gggagtccct tttaggcact tgcttctggt      240

gctgcaactg gcgctcctcc cagcagccac tcagggaaag aaagtggtgc tgggcaaaaa      300

aggggataca gtggaactga cctgtacagc ttcccagaag aagagcatac aattccactg      360

gaaaaactcc aaccagataa agattctggg aaatcagggc tccttcttaa ctaaaggtcc      420

atccaagctg aatgatcgcg ctgactcaag aagaagcctt tgggaccaag gaaactttcc      480

cctgatcatc aagaatctta agatagaaga ctcagatact tacatctgtg aagtggagga      540

ccagaaggag gaggtgcaat tgctagtgtt cggattgact gccaactctg acacccacct      600

gcttcagggg cagagcctga ccctgacctt ggagagcccc cctggtagta gcccctcagt      660

gcaatgtagg agtccaaggg gtaaaaacat acaggggggg aagaccctct ccgtgtctca      720

gctggagctc caggatagtg gcacctggac atgcactgtc ttgcagaacc agaagaaggt      780

ggagttcaaa atagacatcg tggtgctagc tttccagaag gcctccagca tagtctataa      840

gaaagagggg gaacaggtgg agttctcctt cccactcgcc tttacagttg aaaagctgac      900

gggcagtggc gagctgtggt ggcaggcgga gagggcttcc tcctccaagt cttggatcac      960

ctttgacctg aagaacaagg aagtgtctgt aaaacgggtt acccaggacc ctaagctcca     1020

gatgggcaag aagctcccgc tccacctcac cctgccccag gccttgcctc agtatgctgg     1080

ctctggaaac ctcaccctgg cccttgaagc gaaaacagga aagttgcatc aggaagtgaa     1140

cctggtggtg atgagagcca ctcagctcca gaaaaatttg acctgtgagg tgtggggacc     1200

cacctcccct aagctgatgc tgagtttgaa actggagaac aaggaggcaa aggtctcgaa     1260

gcgggagaag gcggtgtggg tgctgaaccc tgaggcgggg atgtggcagt gtctgctgag     1320

tgactcggga caggtcctgc tggaatccaa catcaaggtt ctgcccacat ggtccacccc     1380

ggtgcagcca atggccctga ttgtgctggg gggcgtcgcc ggcctcctgc ttttcattgg     1440

gctaggcatc ttcttctgtg tcaggtgccg gcaccgaagg cgccaagcag agcggatgtc     1500

tcagatcaag agactcctca gtgagaagaa gacctgccag tgtcctcacc ggtttcagaa     1560

gacatgtagc cccatttgag gcacgaggcc aggcagatcc cacttgcagc ctccccaggt     1620

gtctgccccg cgtttcctgc ctgcggacca gatgaatgta gcagatcccc agcctctggc     1680

ctcctgttcg cctcctctac aatttgccat tgtttctcct gggttaggcc ccggcttcac     1740

tggttgagtg ttgctctcta gtttccagag gcttaatcac accgtcctcc acgccatttc     1800

cttttccttc aagcctagcc cttctctcat tatttctctc tgaccctctc cccactgctc     1860

atttggatcc caggggagtg ttcagggcca gccctggctg gcatggaggg tgaggctggg     1920

tgtctggaag catggagcat gggactgttc ttttacaaga caggaccctg ggaccacaga     1980

gggcaggaac ttgcacaaaa tcacacagcc aagccagtca aggatggatg cagatccaga     2040

ggtttctggc agccagtacc tcctgcccca tgctgcccgc ttctcaccct atgtgggtgg     2100

gaccacagac tcacatcctg accttgcaca aacagcccct ctggacacag ccccatgtac     2160

acggcctcaa gggatgtctc acatcctctg tctatttgag acttagaaaa atcctacaag     2220

gctggcagtg acagaactaa gatgatcatc tccagtttat agaccagaac cagagctcag     2280

agaggctaga tgattgatta ccaagtgccg gactagcaag tgctggagtc gggactaacc     2340

caggtccctt gtcccaagtt ccactgctgc ctcttgaatg cagggacaaa tgccacacgg     2400

ctctcaccag tggctagtgg tgggtactca atgtgtactt ttgggttcac agaagcacag     2460

cacccatggg aagggtccat ctcagagaat ttacgagcag ggatgaaggc ctccctgtct     2520

aaaatccctc cttcatcccc cgctggtggc agaatctgtt accagaggac aaagcctttg     2580

gctcttctaa tcagagcgca agctgggagc acaggcactg caggagagaa tgcccagtga     2640

ccagtcactg accctgtgca gaacctcctg gaagcgagct ttgctgggag agggggtagc     2700

tagcctgaga gggaaccctc taagggacct caaaggtgat tgtgccaggc tctgcgcctg     2760

ccccacaccc tcccttaccc tcctccagac cattcaggac acagggaaat cagggttaca     2820

aatcttcttg atccacttct ctcaggatcc cctctcttcc tacccttcct caccacttcc     2880

ctcagtccca actccttttc cctatttcct tctcctcctg tctttaaagc ctgcctcttc     2940

caggaagacc cccctattgc tgctggggct ccccatttgc ttactttgca tttgtgccca     3000

ctctccaccc ctgctcccct gagctgaaat aaaaatacaa taaacttac                 3049


<210>  24
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  25
<211>  3968
<212>  DNA
<213>  Homo sapiens

<400>  25
ggcggaagcg ggagcctctg tcggccgcgg aagcctggag tgggcggtac gcagacgcgc       60

gcggtgagac ccgctgtctg ctcagcggac tctgcccgcc cccacctccc cctgcgtcgg      120

gccgacatga aggactcgct ggtgctgctg ggccgtgtcc cggcgcaccc ggactcccgc      180

tgctggttcc tggcctggaa ccccgcgggg accctgctgg cctcgtgcgg cggcgaccgg      240

agaatccgca tctggggcac ggagggtgac agctggatct gcaagtctgt cctttctgaa      300

ggccaccagc gcaccgtgcg gaaggtagcc tggtccccct gcggtaatta cctggcctct      360

gccagctttg atgctaccac ttgcatttgg aagaagaacc aggatgactt tgagtgtgta      420

accactctcg agggccatga aaatgaggtc aagtcagtgg cttgggcccc atctggcaac      480

ctcctggcca cttgcagccg agataagagc gtttgggtct gggaagttga tgaagaggat      540

gagtatgaat gtgtcagtgt tctcaactcc cacacacagg atgtcaagca tgtggtttgg      600

cacccaagtc aggagctctt agcttctgcc agctatgatg acacagtgaa gctgtaccgg      660

gaggaagagg atgactgggt atgctgtgcc acccttgagg gccatgaatc cactgtgtgg      720

agcttggcct ttgacccgag tggccagcgc ctggcgtctt gtagtgatga ccgtactgtg      780

cgtatctggc gtcagtatct accaggcaat gaacaagggg tggcatgcag cggctctgac      840

cccagttgga aatgtatctg tactttgtcc ggcttccact caaggaccat ttatgacatt      900

gcttggtgtc agctgacagg ggctctggcc acagcttgtg gggatgacgc gatccgcgtg      960

tttcaggagg atcccaactc ggatccacag cagcccacct tctccctgac agcccacttg     1020

catcaggccc attcccagga tgtcaactgt gtggcctgga accccaagga gccagggcta     1080

ctggcctcct gcagtgatga tggggaggtg gccttctgga agtatcagcg gcctgaaggc     1140

ctctgagcta cctcgacttt ggacagagta atgactcccc agaaaacgtc atataagact     1200

ttaccagccc ctgagaggac caggaggagc atccttgacc ttcatttaac ttggctcact     1260

tctcttcaga cttgggtaga agtgcagagc cacagaattg ctttccttcc ccgcctttga     1320

catgaggcct tcagtaaaga gctacagaac atgagtacat tgttatacca cagatttttc     1380

ttgcattagg gcacagtgtt aaattttttg gaggtaaata tactatttat aatcactata     1440

tatagtagga gggggtatgt gtctcaggct tttctgaagt tgcaagactt aaagaaataa     1500

tccatctgca tcccaagtcc tattttataa ggatattcat aaaaattcca tggtgaatcc     1560

ttgtctgaaa taggtcctcc cttcccagtt tctgtgtaag tctttgcatt taagacatcc     1620

aatcaataat gaaggaaatt tttttctgaa tgtaggtttg agtgaggggc acctctgctt     1680

tcccttagca accctcatat acctccctgc accgttacgc tgtgatggca actggggata     1740

gaaaaaaaat ggggaaagac aggaatccta aaagggagag ttattactgg ccacaagccc     1800

tgtattctca acagggatgc aaattggttc ttcagtaagg ataaaaaaaa atcacaagca     1860

gttgtttgtg gccctcctaa ggcccacagc acatatagtg tgtctgtgat attccatttt     1920

catggcaggg agtgatcagg aagaaggctt cctaggggac tggcgattta aaccagttga     1980

gaaacactgc catcagcagg cagtttcaga ctcactcaag ttgtctcttg acagtcactt     2040

ctaaatgggt tctaatgtga caatggcctc caaaactaca gccttccctg aagtttaagc     2100

tgtgacctta gattttagaa ggacagtggg gctgtaccta gaatagtggt tctcgaagaa     2160

tgcggcctgc agatcctggg agtcccaaga ccctttcagg gaggatctgt gaggtcaact     2220

gttggcactg tggcatgaat caaggtggtg gcagcaaact tctagtagtt ttgatatgtc     2280

cttgatagaa caaatagcaa tggttaacta ttaaatgttg acctagccag cgcagtggct     2340

catgcctgta atcccagcac tttgggaggc tgaggcgggc ggatcacctg aggtcgggag     2400

ttcgaggcca gcctgaccaa catggagaaa ccccgtctct tctaaaaata caaaattagc     2460

tgggcatggt ggtgcatgcc tgtaattcca gctactcggg aggctgaggc aagagaatcg     2520

cttgaatccg gtaggtggag gttgcagtga gccgagatca taccattgca ctccagccca     2580

ggcaacaaga gtgaaaccct gtctcaaaaa gaaaaaaaaa gttgaccttg agaatttata     2640

atattctgag aaaactggaa gcatgcataa agcccctctg ctgtgcactg aagtatgggt     2700

gccttgagga aaagcagtta cacagttgag ttgcaagctg aattggctgt gttcaaggca     2760

tgccctttag aattgaaaga actagcagat tacggtattt agacttgaat atttggctga     2820

tattttctgg aaattaatgg aatgagcctc tcacctcaag ggaaacaact gatagtgttg     2880

ccagtgataa agctttcaag caaaaattgg aatttccgaa aatctgtact ccaccatgag     2940

ctttattgtt ggggatatta acaaatgtga tttgtataat gaaatgcatt tcatttggaa     3000

gaattcaatg aaccattttt ccaagtgacc agtacgtgat gttacaaaat catgcatggc     3060

tcaaagattg attcaaaagt gtaagacagg ccagtggatt ttaatgtatt aacaatataa     3120

gagtgcatta agttttcgga gtctacattg cctttaagaa actatgactt gtagtaagcc     3180

gggcgcggtg gctcacgcct gtaatcccaa cactttggga ggccaaggtg ggtggatcac     3240

aaggtcagga gttcaagacc agcctggcca atatggtgaa agtccgtctc tactaaaatt     3300

acaaaaatta gccgggcgtg gtggcagatc ccttgtagtc ccagctactc gggaggctga     3360

ggcaggagaa tagcttgaac ccgggaggtg gaggttgcag tgagtcgaga tcgtgccact     3420

ggactccagc ctgggtgaca gagcgagact ccatttcaaa aaaaaaaaaa aaaaaaaaaa     3480

atcacttgta gtcttggtgt ggtatcaaag aatagccaca attagctgaa aaggctattt     3540

taaaaacttt tccaactgcg tatctgtgtg aagtcaactt acttcaacaa aaaagtttgg     3600

atgtagaagc agctgtaaga attcaactgt ttattataac aagatactaa agagactgta     3660

aaatgccacc cttctccttg gattgttttg gaagttattc ttcataaaaa atgttaacgt     3720

gggctgggca tggtggctca tgcctgtaat cccagcactc tgggaggctg aggtgggcgg     3780

atcacttgag ctcaggaatt caaggtcagc ctgggcaaca tggctaaact ctgtctctat     3840

taagaaaaaa aatgttaaca ttatgattta aaagtgcatt aaccttaatc tagataataa     3900

aagctttttg gggcaacctc cagaactgtg aaaaataaat ttgttattta aaaagaaaaa     3960

aaaaaaaa                                                              3968


<210>  26
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Lys Asp Ser Leu Val Leu Leu Gly Arg Val Pro Ala His Pro Asp 
1               5                   10                  15      


Ser Arg Cys Trp Phe Leu Ala Trp Asn Pro Ala Gly Thr Leu Leu Ala 
            20                  25                  30          


Ser Cys Gly Gly Asp Arg Arg Ile Arg Ile Trp Gly Thr Glu Gly Asp 
        35                  40                  45              


Ser Trp Ile Cys Lys Ser Val Leu Ser Glu Gly His Gln Arg Thr Val 
    50                  55                  60                  


Arg Lys Val Ala Trp Ser Pro Cys Gly Asn Tyr Leu Ala Ser Ala Ser 
65                  70                  75                  80  


Phe Asp Ala Thr Thr Cys Ile Trp Lys Lys Asn Gln Asp Asp Phe Glu 
                85                  90                  95      


Cys Val Thr Thr Leu Glu Gly His Glu Asn Glu Val Lys Ser Val Ala 
            100                 105                 110         


Trp Ala Pro Ser Gly Asn Leu Leu Ala Thr Cys Ser Arg Asp Lys Ser 
        115                 120                 125             


Val Trp Val Trp Glu Val Asp Glu Glu Asp Glu Tyr Glu Cys Val Ser 
    130                 135                 140                 


Val Leu Asn Ser His Thr Gln Asp Val Lys His Val Val Trp His Pro 
145                 150                 155                 160 


Ser Gln Glu Leu Leu Ala Ser Ala Ser Tyr Asp Asp Thr Val Lys Leu 
                165                 170                 175     


Tyr Arg Glu Glu Glu Asp Asp Trp Val Cys Cys Ala Thr Leu Glu Gly 
            180                 185                 190         


His Glu Ser Thr Val Trp Ser Leu Ala Phe Asp Pro Ser Gly Gln Arg 
        195                 200                 205             


Leu Ala Ser Cys Ser Asp Asp Arg Thr Val Arg Ile Trp Arg Gln Tyr 
    210                 215                 220                 


Leu Pro Gly Asn Glu Gln Gly Val Ala Cys Ser Gly Ser Asp Pro Ser 
225                 230                 235                 240 


Trp Lys Cys Ile Cys Thr Leu Ser Gly Phe His Ser Arg Thr Ile Tyr 
                245                 250                 255     


Asp Ile Ala Trp Cys Gln Leu Thr Gly Ala Leu Ala Thr Ala Cys Gly 
            260                 265                 270         


Asp Asp Ala Ile Arg Val Phe Gln Glu Asp Pro Asn Ser Asp Pro Gln 
        275                 280                 285             


Gln Pro Thr Phe Ser Leu Thr Ala His Leu His Gln Ala His Ser Gln 
    290                 295                 300                 


Asp Val Asn Cys Val Ala Trp Asn Pro Lys Glu Pro Gly Leu Leu Ala 
305                 310                 315                 320 


Ser Cys Ser Asp Asp Gly Glu Val Ala Phe Trp Lys Tyr Gln Arg Pro 
                325                 330                 335     


Glu Gly Leu 
            


<210>  27
<211>  2755
<212>  DNA
<213>  Homo sapiens

<400>  27
ccgggccgcg cttcctctcg ccaggcctgc gagcttcctc ccagcggagc cctgggcgag       60

ccgaggttgg ccgccgccgc cgccgagccc gctgccgccc tcccgctcct gccccacccg      120

cgccttgccc gggggcttct gccggggtgg ggtccgagcc gggcgaccgc ccggctgcgc      180

cgccgtcggg gccgtaaccc ggcccgccgt ccctcccgcc ccagccagcc tctggccgcc      240

ggagcccgcg gggcgtggag cgcgaggagc cccgcggccc cgatcgagcg tccggggcgg      300

cccccggcag ccagcgcgac gttccaaaat cgaacctcag tggcggcgct cggaagcgga      360

actctgccgg ggccgcgccg gctacattgt ttcctccccc cgactccctc ccgccccctt      420

cccccgcctt tcttccctcc gcgacccggg ccgtgcgtcc gtccccctgc ctctgcctgg      480

cggtccctcc tcccctctcc ttgcacccat acctctttgt accgcacccc ctggggaccc      540

ctgcgcccct cccctccccc ctgaccgcat ggaccgtccc gcaggccgct gatgccgccc      600

gcggcgaggt ggcccggacc gcagtgcccc aagagagctc taatggtacc aagtgacagg      660

ttggctttac tgtgactcgg ggacgccaga gctcctgaga agatgtcagc aatacaggcc      720

gcctggccat ccggtacaga atgtattgcc aagtacaact tccacggcac tgccgagcag      780

gacctgccct tctgcaaagg agacgtgctc accattgtgg ccgtcaccaa ggaccccaac      840

tggtacaaag ccaaaaacaa ggtgggccgt gagggcatca tcccagccaa ctacgtccag      900

aagcgggagg gcgtgaaggc gggtaccaaa ctcagcctca tgccttggtt ccacggcaag      960

atcacacggg agcaggctga gcggcttctg tacccgccgg agacaggcct gttcctggtg     1020

cgggagagca ccaactaccc cggagactac acgctgtgcg tgagctgcga cggcaaggtg     1080

gagcactacc gcatcatgta ccatgccagc aagctcagca tcgacgagga ggtgtacttt     1140

gagaacctca tgcagctggt ggagcactac acctcagacg cagatggact ctgtacgcgc     1200

ctcattaaac caaaggtcat ggagggcaca gtggcggccc aggatgagtt ctaccgcagc     1260

ggctgggccc tgaacatgaa ggagctgaag ctgctgcaga ccatcgggaa gggggagttc     1320

ggagacgtga tgctgggcga ttaccgaggg aacaaagtcg ccgtcaagtg cattaagaac     1380

gacgccactg cccaggcctt cctggctgaa gcctcagtca tgacgcaact gcggcatagc     1440

aacctggtgc agctcctggg cgtgatcgtg gaggagaagg gcgggctcta catcgtcact     1500

gagtacatgg ccaaggggag ccttgtggac tacctgcggt ctaggggtcg gtcagtgctg     1560

ggcggagact gtctcctcaa gttctcgcta gatgtctgcg aggccatgga atacctggag     1620

ggcaacaatt tcgtgcatcg agacctggct gcccgcaatg tgctggtgtc tgaggacaac     1680

gtggccaagg tcagcgactt tggtctcacc aaggaggcgt ccagcaccca ggacacgggc     1740

aagctgccag tcaagtggac agcccctgag gccctgagag agaagaaatt ctccactaag     1800

tctgacgtgt ggagtttcgg aatccttctc tgggaaatct actcctttgg gcgagtgcct     1860

tatccaagaa ttcccctgaa ggacgtcgtc cctcgggtgg agaagggcta caagatggat     1920

gcccccgacg gctgcccgcc cgcagtctat gaagtcatga agaactgctg gcacctggac     1980

gccgccatgc ggccctcctt cctacagctc cgagagcagc ttgagcacat caaaacccac     2040

gagctgcacc tgtgacggct ggcctccgcc tgggtcatgg gcctgtgggg actgaacctg     2100

gaagatcatg gacctggtgc ccctgctcac tgggcccgag cctgaactga gccccagcgg     2160

gctggcgggc ctttttcctg cgtcccagcc tgcacccctc cggccccgtc tctcttggac     2220

ccacctgtgg ggcctgggga gcccactgag gggccaggga ggaaggaggc cacggagcgg     2280

gaggcagcgc cccaccacgt cgggcttccc tggcctcccg ccactcgcct tcttagagtt     2340

ttattccttt ccttttttga gatttttttt ccgtgtgttt attttttatt atttttcaag     2400

ataaggagaa agaaagtacc cagcaaatgg gcattttaca agaagtacga atcttatttt     2460

tcctgtcctg cccgtgaggg tgggggggac cgggcccctc tctagggacc cctcgcccca     2520

gcctcattcc ccattctgtg tcccatgtcc cgtgtctcct cggtcgcccc gtgtttgcgc     2580

ttgaccatgt tgcactgttt gcatgcgccc gaggcagacg tctgtcaggg gcttggattt     2640

cgtgtgccgc tgccacccgc ccacccgcct tgtgagatgg aattgtaata aaccacgcca     2700

tgaggacacc gccgcccgcc tcggcgcttc ctccaccgag aaaaaaaaaa aaaaa          2755


<210>  28
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  29
<211>  6855
<212>  DNA
<213>  Homo sapiens

<400>  29
ggccggaggg cgcccgaggg gccccgggcc gcggcgctca gggcccgggc ggccggcggc       60

ggccccgggg ctggggggag tccagcccgg atattgagtg cagccattga gaaaagccaa      120

actcttgtgt gtgcgcgtct cgatagcccc caagatggcc gccaatgtgg gatcgatgtt      180

tcaatattgg aagcgatttg atctacggcg actccagaag gagcttaatt ccgtcgcttc      240

tgagctgtct gcacggcagg aggagagtga acattctcat aaacatttaa ttgaactccg      300

ccgggaattt aagaaaaatg tacctgagga aatcagagag atggtggctc ctgtattaaa      360

aagcttccaa gccgaggtgg tggcccttag taagagaagt caggaggcgg aggctgcttt      420

tctgagtgtt tacaagcaat taattgaagc accagacccc gtgcctgtgt ttgaggcggc      480

acgcagccta gacgacagac tgcagccccc cagctttgac cccagtgggc agccccggcg      540

agacctccac acttcgtgga agaggaaccc cgagctcctc agccccaaag agcagagaga      600

ggggacgtcg cctgccgggc ccacgctgac cgagggaagc cgcctcccag gcattcccgg      660

gaaagccctc ctgacagaaa ccttgctgca gagaaatgag gcggaaaaac aaaagggcct      720

tcaagaagta cagatcactt tggcggccag actgggggag gcagaggaga aaatcaaagt      780

cctacattca gcgctaaagg ctacgcaggc agagctgcta gagctgcggc ggaagtacga      840

cgaggaggca gcatccaagg cagatgaagt cggcctgatc atgaccaacc tggagaaagc      900

taatcagcga gctgaggctg cccagcggga ggtggaaagt ctccgggaac agctggcctc      960

tgtcaacagc tccatccgcc tggcttgctg ctctccccag gggcccagtg gggataaggt     1020

gaacttcact ctgtgctcgg gccctcggct ggaggccgcg ctggcctcca aggacaggga     1080

gatcctgcgg ctgctgaagg acgtgcagca cctccagagc tcactgcagg agctggagga     1140

ggcatccgcc aaccagatcg ccgacctgga gcggcagctc acggccaagt ccgaggccat     1200

agaaaagctg gaagagaagc tccaggccca gtctgactat gaggaaatta aaacggagct     1260

gagcatcctg aaagccatga agctggcctc cagcacctgc agcctccccc agggcatggc     1320

caagcctgaa gactcactgc ttattgcaaa ggaggccttc ttccccacgc agaaattcct     1380

tctggagaag cccagcctcc tggccagccc tgaggaagac ccatcagagg acgattccat     1440

caaggattca ctgggcacgg agcagtccta cccctcccct cagcagctcc cacctccacc     1500

agggccagaa gaccccctgt ctcccagccc cgggcagccc ctgctgggcc ccagcttggg     1560

gcctgacggc actcggactt tctcgctgtc ccccttcccc agcctggcat caggggagag     1620

actgatgatg cccccagccg ccttcaaggg agaggcgggc ggcctgctgg tgttcccccc     1680

agccttctat ggcgccaagc cccccacagc ccctgccacc ccggcccctg gccctgagcc     1740

actgggcggt cctgagcccg cggatggtgg tgggggcgga gcggcggggc ccggggcaga     1800

ggaggagcag ctggacacgg cagagatcgc cttccaggtg aaggagcagc tgctgaaaca     1860

caacatcggg cagcgggtgt ttgggcatta cgtgctgggg ctgtcgcagg gctcggtcag     1920

cgagatccta gcccggccca agccctggcg caagctcacg gtgaagggca aggagccctt     1980

catcaagatg aagcagttcc tgtcggatga gcagaatgta ctggcgctca ggaccatcca     2040

agtgcggcag cgaggcagca tcaccccgag aatccgcacg cctgagacag gctcagacga     2100

cgccatcaag agcattctag agcaggccaa gaaggagatc gagtcgcaga agggcggcga     2160

gcccaagacc tcggtggccc cgctgagcat cgccaacggc acgacccccg ccagcacctc     2220

ggaggacgcc atcaagagca tcctggagca ggcacgccgt gagatgcagg cgcaacagca     2280

ggcgctgctg gagatggagg tggcgcccag gggccgctcg gtgcccccct cgcccccgga     2340

gcggccatca ctggccaccg cgagccagaa cggggccccg gccttggtga agcaggagga     2400

gggcagcggg ggccccgcgc aggcgccgct cccggtcctg tcccccgccg ccttcgtgca     2460

gagcatcatc cgcaaggtca agtccgagat cggcgacgcc ggctacttcg accaccactg     2520

ggcctccgac cgcggcctgc tcagccgccc ctacgcctcc gtgtcgccct cgctgtcctc     2580

ctcctcctcc tctggctact ctggccagcc caacggccgc gcctggcccc gcggggacga     2640

ggcccctgtg ccccccgagg acgaggcggc ggcaggggcg gaggacgaac cccccaggac     2700

gggcgagctc aaggctgagg gcgcgacggc cgaggcgggc gcgcggctgc cctactaccc     2760

ggcctacgtg ccgcgcaccc tgaagcccac cgtgccgccg ctgacccccg agcagtacga     2820

gctgtacatg taccgtgagg tagacacgct ggagctcacc cgccaggtca aggagaagct     2880

ggccaagaac ggcatctgcc agaggatctt cggggagaag gtgctgggcc tgtcacaggg     2940

cagcgtgagc gacatgctgt cccggccgaa gccatggagc aagctgacgc agaaggggcg     3000

ggagcccttc atccgcatgc agctgtggct ctctgaccag ctcggccagg cagtgggcca     3060

gcagcctggt gcctcccagg ccagtcccac agaaccaagg tcctcaccat ccccaccccc     3120

cagccccaca gagcctgaga agagctccca ggagccgttg agcctgtccc tggagagcag     3180

caaggagaac cagcagccag agggccgctc cagctcctcg ttgagcggga agatgtactc     3240

aggcagccag gccccagggg gcatccagga gatcgtggcc atgtcccccg agctggacac     3300

gtactccatc accaagaggg tgaaggaggt cctcacagac aacaatctag ggcagcggct     3360

gtttggggaa agcatcctgg gtctgacaca gggctccgtg tctgacctgc tgtcccggcc     3420

caaaccctgg cacaagctga gcctgaaggg gcgggagcct tttgtccgca tgcagctgtg     3480

gctcaatgac ccccataacg tggagaagct gagggatatg aagaagctgg agaagaaagc     3540

ctacctgaaa cgtcgctatg gcctcatcag caccggctca gacagtgagt ccccggccac     3600

ccgctcagag tgccccagcc cctgcctgca gccccaggac ctgagcctcc tgcagatcaa     3660

gaagccccgg gtggtgctgg cacccgagga gaaggaggca ctgcggaagg cctatcagct     3720

ggaaccctac ccctcgcagc agaccatcga gctcctctcc ttccagctca acctcaagac     3780

caacaccgtc atcaactggt tccacaacta caggtcccgg atgcgccggg agatgttggt     3840

ggaggggacc caggatgagc cagaccttga tccaagcggg ggtcctggaa tcctaccgcc     3900

aggccactcc cacccagacc ccaccccgca gagccctgac tctgagactg aggaccagaa     3960

gccaaccgtg aaggaactgg agcttcagga gggccctgag gagaacagca cacccctgac     4020

cacccaggac aaggcccaag tgaggatcaa gcaggaacag atggaggagg atgctgagga     4080

agaggcaggc agccagcccc aggactcagg ggagctggac aaaggccaag gtccccccaa     4140

agaggagcat cccgaccctc cgggtaatga tggactccca aaagtggctc ccgggcccct     4200

ccttccaggt ggatccaccc cagactgtcc ctcacttcat ccccaacagg agagtgaggc     4260

cggggagcga cttcacccgg accctttaag ttttaagtca gcctcagagt cctcacgctg     4320

cagcctggag gtgtcactga actcgccctc ggccgcctcc tcaccaggcc tcatgatgtc     4380

tgtgtcacct gtcccctcct cctcagctcc catctcccca tccccacctg gcgccccccc     4440

tgccaaagtg ccgagtgcca gccccactgc tgacatggct ggagccttgc accccagtgc     4500

caaggtgaac cccaacttgc agcggcggca tgagaagatg gccaatctga acaacatcat     4560

ttaccgagta gagcgggctg ccaatcggga ggaggccctg gagtgggagt tctgaaggca     4620

gggtgagggg gcaagggaca taccctggta actaccttcc ttctcgcact tactctcctc     4680

aacaggatgg ggtaagggag ggaggaactc aaccatcaaa atgtggacag caatgttatg     4740

ccgtttacgt tttttgttgt aatcctagtt ctatgaagct gtgtgagcag gtgggtcaaa     4800

tgccattgcc tccacttttc tgcacccccc tgctcctctt caccctgacc cctctgcagg     4860

aggcagaagc aaaatggcac cacatattca cctgaaaact ccaaactctt ttagaaaaat     4920

aaataaatat ttatagacct cttttagata ttttaataaa ggatcctttg gaatttatcc     4980

cagctgatgc tgttttgata ttacagagag ttataaaatc aggatgctgt cacaactgtt     5040

gcgaagtata cactgaagtt gtgtcgtttt tgccactaga tgagattaaa agaagacaat     5100

tattcaaagc catcacaaaa cactataaga ctgaccaaaa tttagataac ctttgaacca     5160

cgattttttt ccacatctgt ctgtgagaca cagcgcaatg ctactgccct tccagaaact     5220

gtgctaaaaa gagaaagtcc aaaagactct aaacaaaaac ctcgacgccg ttgaggatgt     5280

gtttcattct ggtggtctgt tttgcaagct tgataacaga atgtccgtgc cattgtaaat     5340

gttgtagaga tgtgggccgt ggcccaaccg tcctatatga gatgtagcat ggtacagaac     5400

aaactgctta cacaggtctc actagttaga aacctgtggg ccatggaggt cagacatcca     5460

tcttgtccat ctataggcaa gaagtgtttc cagatccttt ggaaaggtgg gcatggggca     5520

ggtgcttgga gagtggcgtt tgagccagag cgaccccatt tcccgtgtga accataggca     5580

caacccagga agtttcccca cttgtaggag tgtgggtatt ccagagcaag actgtggcca     5640

ccatcttccc ctcttggtgt tttccgaaag tgacagtgtt ggtcatccca tgaccactga     5700

agcttagtaa ccagcgccaa aaagtagatt catcaaacta gagaccccag ctccccttct     5760

cgccatcttc tttctcaagt tgaccgtggt gctgtttctg gaaggcatct gcaactccaa     5820

gtccatgcag aactctggaa ggccaagttc atcgcagcat gttcaccata tcccagcctc     5880

caaatctatc ctcctacctt ccaacgcatg acctgttggg gagcagagac ttaaccccca     5940

actcagagga acccttcctc cagcgtcttt ggcatggttt ctagggtgag agttcccaat     6000

ttggatagaa cggccaccat attggttact gaatctctct cccttgtttt tattacgttt     6060

cctttttcaa actgtccatg ggaaggctga attgagtgac tccccagaat gaagatgaga     6120

aggtgaatat aatcaatgcc aatgtaatgc cagcgggtga gatggccgat ggaggtttca     6180

aagatgtagc tagcattttg aaaccatatg ggcaaaaccc ggcaaccaga aggggacaga     6240

taaggaccgt tccagaaatc ccaactctca cacccagccc aggctgcagt ctccacacca     6300

aacagtcaac aaaacacaaa ccctgaagga aaaccttttc catacaccca ggctatgcat     6360

tgaagagttt tccactgtat acatttttat ccagatgaag gtatttttat attttgacaa     6420

taggaaacag tgaccatttt cagagtaatc aaatctggaa caaatgaaac atcttttagc     6480

caccaccacc ctgttgcaat taagacaacc gtgggggaac acaccacttt ttactgttga     6540

aaccaacaca acgttgaaat ccaggcttat acgcagactc cgattcctag agaactaaat     6600

ttggctttag tgtgacggga tttgattaag cacttagtat agtcttttga acacggaaat     6660

cctgttgtac ttaaagctag cggacccgtg aacaactttg tcaggttcac gtcctataac     6720

ggttaaaaaa cacacacaca catacacaaa ccgtttctat gagagattga tgaactttgt     6780

ttaaaatttt aaaaaaagga acacgttctg taaacgagtc gctaaataca gaattgtata     6840

ataaaaaaaa aaaaa                                                      6855


<210>  30
<211>  1486
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Arg Arg Leu Gln Lys Glu Leu Asn Ser Val Ala Ser Glu Leu Ser 
            20                  25                  30          


Ala Arg Gln Glu Glu Ser Glu His Ser His Lys His Leu Ile Glu Leu 
        35                  40                  45              


Arg Arg Glu Phe Lys Lys Asn Val Pro Glu Glu Ile Arg Glu Met Val 
    50                  55                  60                  


Ala Pro Val Leu Lys Ser Phe Gln Ala Glu Val Val Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Gln Glu Ala Glu Ala Ala Phe Leu Ser Val Tyr Lys Gln Leu 
                85                  90                  95      


Ile Glu Ala Pro Asp Pro Val Pro Val Phe Glu Ala Ala Arg Ser Leu 
            100                 105                 110         


Asp Asp Arg Leu Gln Pro Pro Ser Phe Asp Pro Ser Gly Gln Pro Arg 
        115                 120                 125             


Arg Asp Leu His Thr Ser Trp Lys Arg Asn Pro Glu Leu Leu Ser Pro 
    130                 135                 140                 


Lys Glu Gln Arg Glu Gly Thr Ser Pro Ala Gly Pro Thr Leu Thr Glu 
145                 150                 155                 160 


Gly Ser Arg Leu Pro Gly Ile Pro Gly Lys Ala Leu Leu Thr Glu Thr 
                165                 170                 175     


Leu Leu Gln Arg Asn Glu Ala Glu Lys Gln Lys Gly Leu Gln Glu Val 
            180                 185                 190         


Gln Ile Thr Leu Ala Ala Arg Leu Gly Glu Ala Glu Glu Lys Ile Lys 
        195                 200                 205             


Val Leu His Ser Ala Leu Lys Ala Thr Gln Ala Glu Leu Leu Glu Leu 
    210                 215                 220                 


Arg Arg Lys Tyr Asp Glu Glu Ala Ala Ser Lys Ala Asp Glu Val Gly 
225                 230                 235                 240 


Leu Ile Met Thr Asn Leu Glu Lys Ala Asn Gln Arg Ala Glu Ala Ala 
                245                 250                 255     


Gln Arg Glu Val Glu Ser Leu Arg Glu Gln Leu Ala Ser Val Asn Ser 
            260                 265                 270         


Ser Ile Arg Leu Ala Cys Cys Ser Pro Gln Gly Pro Ser Gly Asp Lys 
        275                 280                 285             


Val Asn Phe Thr Leu Cys Ser Gly Pro Arg Leu Glu Ala Ala Leu Ala 
    290                 295                 300                 


Ser Lys Asp Arg Glu Ile Leu Arg Leu Leu Lys Asp Val Gln His Leu 
305                 310                 315                 320 


Gln Ser Ser Leu Gln Glu Leu Glu Glu Ala Ser Ala Asn Gln Ile Ala 
                325                 330                 335     


Asp Leu Glu Arg Gln Leu Thr Ala Lys Ser Glu Ala Ile Glu Lys Leu 
            340                 345                 350         


Glu Glu Lys Leu Gln Ala Gln Ser Asp Tyr Glu Glu Ile Lys Thr Glu 
        355                 360                 365             


Leu Ser Ile Leu Lys Ala Met Lys Leu Ala Ser Ser Thr Cys Ser Leu 
    370                 375                 380                 


Pro Gln Gly Met Ala Lys Pro Glu Asp Ser Leu Leu Ile Ala Lys Glu 
385                 390                 395                 400 


Ala Phe Phe Pro Thr Gln Lys Phe Leu Leu Glu Lys Pro Ser Leu Leu 
                405                 410                 415     


Ala Ser Pro Glu Glu Asp Pro Ser Glu Asp Asp Ser Ile Lys Asp Ser 
            420                 425                 430         


Leu Gly Thr Glu Gln Ser Tyr Pro Ser Pro Gln Gln Leu Pro Pro Pro 
        435                 440                 445             


Pro Gly Pro Glu Asp Pro Leu Ser Pro Ser Pro Gly Gln Pro Leu Leu 
    450                 455                 460                 


Gly Pro Ser Leu Gly Pro Asp Gly Thr Arg Thr Phe Ser Leu Ser Pro 
465                 470                 475                 480 


Phe Pro Ser Leu Ala Ser Gly Glu Arg Leu Met Met Pro Pro Ala Ala 
                485                 490                 495     


Phe Lys Gly Glu Ala Gly Gly Leu Leu Val Phe Pro Pro Ala Phe Tyr 
            500                 505                 510         


Gly Ala Lys Pro Pro Thr Ala Pro Ala Thr Pro Ala Pro Gly Pro Glu 
        515                 520                 525             


Pro Leu Gly Gly Pro Glu Pro Ala Asp Gly Gly Gly Gly Gly Ala Ala 
    530                 535                 540                 


Gly Pro Gly Ala Glu Glu Glu Gln Leu Asp Thr Ala Glu Ile Ala Phe 
545                 550                 555                 560 


Gln Val Lys Glu Gln Leu Leu Lys His Asn Ile Gly Gln Arg Val Phe 
                565                 570                 575     


Gly His Tyr Val Leu Gly Leu Ser Gln Gly Ser Val Ser Glu Ile Leu 
            580                 585                 590         


Ala Arg Pro Lys Pro Trp Arg Lys Leu Thr Val Lys Gly Lys Glu Pro 
        595                 600                 605             


Phe Ile Lys Met Lys Gln Phe Leu Ser Asp Glu Gln Asn Val Leu Ala 
    610                 615                 620                 


Leu Arg Thr Ile Gln Val Arg Gln Arg Gly Ser Ile Thr Pro Arg Ile 
625                 630                 635                 640 


Arg Thr Pro Glu Thr Gly Ser Asp Asp Ala Ile Lys Ser Ile Leu Glu 
                645                 650                 655     


Gln Ala Lys Lys Glu Ile Glu Ser Gln Lys Gly Gly Glu Pro Lys Thr 
            660                 665                 670         


Ser Val Ala Pro Leu Ser Ile Ala Asn Gly Thr Thr Pro Ala Ser Thr 
        675                 680                 685             


Ser Glu Asp Ala Ile Lys Ser Ile Leu Glu Gln Ala Arg Arg Glu Met 
    690                 695                 700                 


Gln Ala Gln Gln Gln Ala Leu Leu Glu Met Glu Val Ala Pro Arg Gly 
705                 710                 715                 720 


Arg Ser Val Pro Pro Ser Pro Pro Glu Arg Pro Ser Leu Ala Thr Ala 
                725                 730                 735     


Ser Gln Asn Gly Ala Pro Ala Leu Val Lys Gln Glu Glu Gly Ser Gly 
            740                 745                 750         


Gly Pro Ala Gln Ala Pro Leu Pro Val Leu Ser Pro Ala Ala Phe Val 
        755                 760                 765             


Gln Ser Ile Ile Arg Lys Val Lys Ser Glu Ile Gly Asp Ala Gly Tyr 
    770                 775                 780                 


Phe Asp His His Trp Ala Ser Asp Arg Gly Leu Leu Ser Arg Pro Tyr 
785                 790                 795                 800 


Ala Ser Val Ser Pro Ser Leu Ser Ser Ser Ser Ser Ser Gly Tyr Ser 
                805                 810                 815     


Gly Gln Pro Asn Gly Arg Ala Trp Pro Arg Gly Asp Glu Ala Pro Val 
            820                 825                 830         


Pro Pro Glu Asp Glu Ala Ala Ala Gly Ala Glu Asp Glu Pro Pro Arg 
        835                 840                 845             


Thr Gly Glu Leu Lys Ala Glu Gly Ala Thr Ala Glu Ala Gly Ala Arg 
    850                 855                 860                 


Leu Pro Tyr Tyr Pro Ala Tyr Val Pro Arg Thr Leu Lys Pro Thr Val 
865                 870                 875                 880 


Pro Pro Leu Thr Pro Glu Gln Tyr Glu Leu Tyr Met Tyr Arg Glu Val 
                885                 890                 895     


Asp Thr Leu Glu Leu Thr Arg Gln Val Lys Glu Lys Leu Ala Lys Asn 
            900                 905                 910         


Gly Ile Cys Gln Arg Ile Phe Gly Glu Lys Val Leu Gly Leu Ser Gln 
        915                 920                 925             


Gly Ser Val Ser Asp Met Leu Ser Arg Pro Lys Pro Trp Ser Lys Leu 
    930                 935                 940                 


Thr Gln Lys Gly Arg Glu Pro Phe Ile Arg Met Gln Leu Trp Leu Ser 
945                 950                 955                 960 


Asp Gln Leu Gly Gln Ala Val Gly Gln Gln Pro Gly Ala Ser Gln Ala 
                965                 970                 975     


Ser Pro Thr Glu Pro Arg Ser Ser Pro Ser Pro Pro Pro Ser Pro Thr 
            980                 985                 990         


Glu Pro Glu Lys Ser Ser Gln Glu  Pro Leu Ser Leu Ser  Leu Glu Ser 
        995                 1000                 1005             


Ser Lys  Glu Asn Gln Gln Pro  Glu Gly Arg Ser Ser  Ser Ser Leu 
    1010                 1015                 1020             


Ser Gly  Lys Met Tyr Ser Gly  Ser Gln Ala Pro Gly  Gly Ile Gln 
    1025                 1030                 1035             


Glu Ile  Val Ala Met Ser Pro  Glu Leu Asp Thr Tyr  Ser Ile Thr 
    1040                 1045                 1050             


Lys Arg  Val Lys Glu Val Leu  Thr Asp Asn Asn Leu  Gly Gln Arg 
    1055                 1060                 1065             


Leu Phe  Gly Glu Ser Ile Leu  Gly Leu Thr Gln Gly  Ser Val Ser 
    1070                 1075                 1080             


Asp Leu  Leu Ser Arg Pro Lys  Pro Trp His Lys Leu  Ser Leu Lys 
    1085                 1090                 1095             


Gly Arg  Glu Pro Phe Val Arg  Met Gln Leu Trp Leu  Asn Asp Pro 
    1100                 1105                 1110             


His Asn  Val Glu Lys Leu Arg  Asp Met Lys Lys Leu  Glu Lys Lys 
    1115                 1120                 1125             


Ala Tyr  Leu Lys Arg Arg Tyr  Gly Leu Ile Ser Thr  Gly Ser Asp 
    1130                 1135                 1140             


Ser Glu  Ser Pro Ala Thr Arg  Ser Glu Cys Pro Ser  Pro Cys Leu 
    1145                 1150                 1155             


Gln Pro  Gln Asp Leu Ser Leu  Leu Gln Ile Lys Lys  Pro Arg Val 
    1160                 1165                 1170             


Val Leu  Ala Pro Glu Glu Lys  Glu Ala Leu Arg Lys  Ala Tyr Gln 
    1175                 1180                 1185             


Leu Glu  Pro Tyr Pro Ser Gln  Gln Thr Ile Glu Leu  Leu Ser Phe 
    1190                 1195                 1200             


Gln Leu  Asn Leu Lys Thr Asn  Thr Val Ile Asn Trp  Phe His Asn 
    1205                 1210                 1215             


Tyr Arg  Ser Arg Met Arg Arg  Glu Met Leu Val Glu  Gly Thr Gln 
    1220                 1225                 1230             


Asp Glu  Pro Asp Leu Asp Pro  Ser Gly Gly Pro Gly  Ile Leu Pro 
    1235                 1240                 1245             


Pro Gly  His Ser His Pro Asp  Pro Thr Pro Gln Ser  Pro Asp Ser 
    1250                 1255                 1260             


Glu Thr  Glu Asp Gln Lys Pro  Thr Val Lys Glu Leu  Glu Leu Gln 
    1265                 1270                 1275             


Glu Gly  Pro Glu Glu Asn Ser  Thr Pro Leu Thr Thr  Gln Asp Lys 
    1280                 1285                 1290             


Ala Gln  Val Arg Ile Lys Gln  Glu Gln Met Glu Glu  Asp Ala Glu 
    1295                 1300                 1305             


Glu Glu  Ala Gly Ser Gln Pro  Gln Asp Ser Gly Glu  Leu Asp Lys 
    1310                 1315                 1320             


Gly Gln  Gly Pro Pro Lys Glu  Glu His Pro Asp Pro  Pro Gly Asn 
    1325                 1330                 1335             


Asp Gly  Leu Pro Lys Val Ala  Pro Gly Pro Leu Leu  Pro Gly Gly 
    1340                 1345                 1350             


Ser Thr  Pro Asp Cys Pro Ser  Leu His Pro Gln Gln  Glu Ser Glu 
    1355                 1360                 1365             


Ala Gly  Glu Arg Leu His Pro  Asp Pro Leu Ser Phe  Lys Ser Ala 
    1370                 1375                 1380             


Ser Glu  Ser Ser Arg Cys Ser  Leu Glu Val Ser Leu  Asn Ser Pro 
    1385                 1390                 1395             


Ser Ala  Ala Ser Ser Pro Gly  Leu Met Met Ser Val  Ser Pro Val 
    1400                 1405                 1410             


Pro Ser  Ser Ser Ala Pro Ile  Ser Pro Ser Pro Pro  Gly Ala Pro 
    1415                 1420                 1425             


Pro Ala  Lys Val Pro Ser Ala  Ser Pro Thr Ala Asp  Met Ala Gly 
    1430                 1435                 1440             


Ala Leu  His Pro Ser Ala Lys  Val Asn Pro Asn Leu  Gln Arg Arg 
    1445                 1450                 1455             


His Glu  Lys Met Ala Asn Leu  Asn Asn Ile Ile Tyr  Arg Val Glu 
    1460                 1465                 1470             


Arg Ala  Ala Asn Arg Glu Glu  Ala Leu Glu Trp Glu  Phe 
    1475                 1480                 1485     


<210>  31
<211>  4628
<212>  DNA
<213>  Homo sapiens

<400>  31
gaacgtagct agctgcaagc agaggccggc atgaccaccg agcagcgacg cagcctgcaa       60

gccttccagg attatatccg gaagaccctg gaccctacct acatcctgag ctacatggcc      120

ccctggttta gggaggaaga ggtgcagtat attcaggctg agaaaaacaa caagggccca      180

atggaggctg ccacactttt tctcaagttc ctgttggagc tccaggagga aggctggttc      240

cgtggctttt tggatgccct agaccatgca ggttattctg gactttatga agccattgaa      300

agttgggatt tcaaaaaaat tgaaaagttg gaggagtata gattactttt aaaacgttta      360

caaccagaat ttaaaaccag aattatccca accgatatca tttctgatct gtctgaatgt      420

ttaattaatc aggaatgtga agaaattcta cagatttgct ctactaaggg gatgatggca      480

ggtgcagaga aattggtgga atgccttctc agatcagaca aggaaaactg gcccaaaact      540

ttgaaacttg ctttggagaa agaaaggaac aagttcagtg aactgtggat tgtagagaaa      600

ggtataaaag atgttgaaac agaagatctt gaggataaga tggaaacttc tgacatacag      660

attttctacc aagaagatcc agaatgccag aatcttagtg agaattcatg tccaccttca      720

gaagtgtctg atacaaactt gtacagccca tttaaaccaa gaaattacca attagagctt      780

gctttgcctg ctatgaaagg aaaaaacaca ataatatgtg ctcctacagg ttgtggaaaa      840

acctttgttt cactgcttat atgtgaacat catcttaaaa aattcccaca aggacaaaag      900

gggaaagttg tcttttttgc gaatcagatc ccagtgtatg aacagcagaa atctgtattc      960

tcaaaatact ttgaaagaca tgggtataga gttacaggca tttctggagc aacagctgag     1020

aatgtcccag tggaacagat tgttgagaac aatgacatca tcattttaac tccacagatt     1080

cttgtgaaca accttaaaaa gggaacgatt ccatcactat ccatctttac tttgatgata     1140

tttgatgaat gccacaacac tagtaaacaa cacccgtaca atatgatcat gtttaattat     1200

ctagatcaga aacttggagg atcttcaggc ccactgcccc aggtcattgg gctgactgcc     1260

tcggttggtg ttggggatgc caaaaacaca gatgaagcct tggattatat ctgcaagctg     1320

tgtgcttctc ttgatgcgtc agtgatagca acagtcaaac acaatctgga ggaactggag     1380

caagttgttt ataagcccca gaagtttttc aggaaagtgg aatcacggat tagcgacaaa     1440

tttaaataca tcatagctca gctgatgagg gacacagaga gtctggcaaa gagaatctgc     1500

aaagacctcg aaaacttatc tcaaattcaa aatagggaat ttggaacaca gaaatatgaa     1560

caatggattg ttacagttca gaaagcatgc atggtgttcc agatgccaga caaagatgaa     1620

gagagcagga tttgtaaagc cctgttttta tacacttcac atttgcggaa atataatgat     1680

gccctcatta tcagtgagca tgcacgaatg aaagatgctc tggattactt gaaagacttc     1740

ttcagcaatg tccgagcagc aggattcgat gagattgagc aagatcttac tcagagattt     1800

gaagaaaagc tgcaggaact agaaagtgtt tccagggatc ccagcaatga gaatcctaaa     1860

cttgaagacc tctgcttcat cttacaagaa gagtaccact taaacccaga gacaataaca     1920

attctctttg tgaaaaccag agcacttgtg gacgctttaa aaaattggat tgaaggaaat     1980

cctaaactca gttttctaaa acctggcata ttgactggac gtggcaaaac aaatcagaac     2040

acaggaatga ccctcccggc acagaagtgt atattggatg cattcaaagc cagtggagat     2100

cacaatattc tgattgccac ctcagttgct gatgaaggca ttgacattgc acagtgcaat     2160

cttgtcatcc tttatgagta tgtgggcaat gtcatcaaaa tgatccaaac cagaggcaga     2220

ggaagagcaa gaggtagcaa gtgcttcctt ctgactagta atgctggtgt aattgaaaaa     2280

gaacaaataa acatgtacaa agaaaaaatg atgaatgact ctattttacg ccttcagaca     2340

tgggacgaag cagtatttag ggaaaagatt ctgcatatac agactcatga aaaattcatc     2400

agagatagtc aagaaaaacc aaaacctgta cctgataagg aaaataaaaa actgctctgc     2460

agaaagtgca aagccttggc atgttacaca gctgacgtaa gagtgataga ggaatgccat     2520

tacactgtgc ttggagatgc ttttaaggaa tgctttgtga gtagaccaca tcccaagcca     2580

aagcagtttt caagttttga aaaaagagca aagatattct gtgcccgaca gaactgcagc     2640

catgactggg gaatccatgt gaagtacaag acatttgaga ttccagttat aaaaattgaa     2700

agttttgtgg tggaggatat tgcaactgga gttcagacac tgtactcgaa gtggaaggac     2760

tttcattttg agaagatacc atttgatcca gcagaaatgt ccaaatgata tcaggtcctc     2820

aatcttcagc tacagggaat gagtaacttt gagtggagaa gaaacaaaca tagtgggtat     2880

aatcatggat cgcttgtacc cctgtgaaaa tatatttttt aaaaatatct ttagcagttt     2940

gtactatatt atatatgcaa agcacaaatg agtgaatcac agcactgagt attttgtagg     3000

ccaacagagc tcatagtact tgggaaaaat taaaaagcct catttctagc cttcttttta     3060

gagtcaactg ccaacaaaca cacagtaatc actctgtaca cactgggata gatgaatgaa     3120

tggaatgttg ggaattttta tctccctttg tctccttaac ctactgtaaa ctggcttttg     3180

cccttaacaa tctactgaaa ttgttctttt gaaggttacc agtgactctg gttgccaaat     3240

ccactgggca cttcttaacc ttctatttga cctctgcgca tttggccctg ttgagcactc     3300

ttcttgaagc tctccctggg cttctctctc ttctagttct attctagtct ttttttattg     3360

agtcctcctc tttgctgatc ccttccaagg gttcaatata tatacatgta tatactgtac     3420

atatgtatat gtaactaata tacatacata caggtatgta tatgtaatgg ttatatgtac     3480

tcatgttcct ggtgtagcaa cgtgtggtat ggctacacag agaacatgag aacataaagc     3540

catttttatg cttactacta aaagctgtcc actgtagagt tgctgtatgt agcaatgtgt     3600

atccactcta cagtggtcag cttttagtag agagcataaa aatgataaaa tacttcttga     3660

aaacttagtt tactatacat cttgccctat taatatgttc tcttaacgtg tgccattgtt     3720

ctctttgacc attttcctat aatgatgttg atgttcaaca cctggactga atgtctgttc     3780

tcagatccct tggatgttac agatgaggca gtctgactgt cctttctact tgaaagatta     3840

gaatatgtat ccaaatggca ttcacgtgtc acttagcaag gtttgctgat gcttcaaaga     3900

gcttagtttg cggtttcctg gacgtggaaa caagtatctg agttccctgg agatcaacgg     3960

gatgaggtgt tacagctgcc tccctcttca tgcaatctgg tgagcagtgg tgcaggcggg     4020

gagccagaga aacttgccag ttatataact tctctttggc ttttcttcat ctgtaaaaca     4080

aggataatac tgaactgtaa gggttagtgg agagttttta attaaaagaa tgtgtgaaaa     4140

gtacatgaca cagtagttgc ttgataatag ttactagtag tagtattctt actaagaccc     4200

aatacaaatg gattatttaa accaagttta tgagttggtt ttttttcatt ttctatttgt     4260

attttattaa gagtgtcttt tcttatgtga ttttttttaa ttgctatttg atatggtttg     4320

gctatatgtc cccacccaaa tctcatcttg aattataatc cccatgtgtc aagggaggga     4380

cctgacggga ggtgattgga tcacgggggc agttgtcccc atgctgttct tgggatagtg     4440

agttagttct catgagatct gatggtttta taagtgtttg acaattcctc ctttacacac     4500

actctctctc tcatctgctg ccatgtaaga cttgcctgct tccccttctg ccatgattgt     4560

aagtttcctg aggcctcctc agccatgtgg aactgtgaat ctattaagcc tcttttcttt     4620

ataaatga                                                              4628


<210>  32
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile 
1               5                   10                  15      


Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp 
            20                  25                  30          


Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys 
        35                  40                  45              


Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala 
65                  70                  75                  80  


Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys 
                85                  90                  95      


Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro 
            100                 105                 110         


Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser 
        115                 120                 125             


Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser 
    130                 135                 140                 


Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu 
145                 150                 155                 160 


Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu 
                165                 170                 175     


Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile 
            180                 185                 190         


Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp 
        195                 200                 205             


Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu 
    210                 215                 220                 


Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro 
225                 230                 235                 240 


Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro Ala Met Lys 
                245                 250                 255     


Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly Lys Thr Phe 
            260                 265                 270         


Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe Pro Gln Gly 
        275                 280                 285             


Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro Val Tyr Glu 
    290                 295                 300                 


Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His Gly Tyr Arg 
305                 310                 315                 320 


Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro Val Glu Gln 
                325                 330                 335     


Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln Ile Leu Val 
            340                 345                 350         


Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile Phe Thr Leu 
        355                 360                 365             


Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His Pro Tyr Asn 
    370                 375                 380                 


Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly Val Gly Asp 
                405                 410                 415     


Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys Leu Cys Ala 
            420                 425                 430         


Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn Leu Glu Glu 
        435                 440                 445             


Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg Lys Val Glu 
    450                 455                 460                 


Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln Leu Met Arg 
465                 470                 475                 480 


Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu Glu Asn Leu 
                485                 490                 495     


Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr Glu Gln Trp 
            500                 505                 510         


Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met Pro Asp Lys 
        515                 520                 525             


Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr Thr Ser His 
    530                 535                 540                 


Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His Ala Arg Met 
545                 550                 555                 560 


Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn Val Arg Ala 
                565                 570                 575     


Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr Gln Arg Phe Glu Glu 
            580                 585                 590         


Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser Asn Glu Asn 
        595                 600                 605             


Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu Tyr His Leu 
    610                 615                 620                 


Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg Ala Leu Val 
625                 630                 635                 640 


Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu Ser Phe Leu 
                645                 650                 655     


Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln Asn Thr Gly 
            660                 665                 670         


Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe Lys Ala Ser 
        675                 680                 685             


Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp Glu Gly Ile 
    690                 695                 700                 


Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr Val Gly Asn 
705                 710                 715                 720 


Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala Arg Gly Ser 
                725                 730                 735     


Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu Lys Glu Gln 
            740                 745                 750         


Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile Leu Arg Leu 
        755                 760                 765             


Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu His Ile Gln 
    770                 775                 780                 


Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro Lys Pro Val 
785                 790                 795                 800 


Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys Lys Ala Leu 
                805                 810                 815     


Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys His Tyr Thr 
            820                 825                 830         


Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg Pro His Pro 
        835                 840                 845             


Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys Ile Phe Cys 
    850                 855                 860                 


Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val Lys Tyr Lys 
865                 870                 875                 880 


Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val Val Glu Asp 
                885                 890                 895     


Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys Asp Phe His 
            900                 905                 910         


Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys 
        915                 920                 925 


<210>  33
<211>  4493
<212>  DNA
<213>  Homo sapiens

<400>  33
gccatttcgc cgattcctcc atgcgagttg ctgtgcgttt ctctgttgtc tcggtagaag       60

gccagagtca cacacggtcc taagagctgg gcaccaggaa gcgaaggctg atctgaagaa      120

gacacttgaa tcatgggtga cgttaaaaat tttctgtatg cctggtgtgg caaaaggaag      180

atgaccccat cctatgaaat tagagcagtg gggaacaaaa acaggcagaa attcatgtgt      240

gaggttcagg tggaaggtta taattacact ggcatgggaa attccaccaa taaaaaagat      300

gcacaaagca atgctgccag agactttgtt aactatttgg ttcgaataaa tgaaataaag      360

agtgaagaag ttccagcttt tggggtagca tctccgcccc cacttactga tactcctgac      420

actacagcaa atgctgaagg agatttacca acaaccatgg gaggacctct tcctccacat      480

ctggctctca aagcagaaaa taattctgag gtaggggcct ctggctatgg tgttcctggg      540

cccacctggg accgaggagc caacttgaag gattactact caagaaagga agaacaagaa      600

gtgcaagcga ctctagaatc agaagaagtg gatttaaatg ctgggcttca tggaaactgg      660

accttggaaa atgctaaagc tcgtctaaac caatattttc agaaagaaaa gatccaagga      720

gaatataagt acacccaagt gggtcctgat cacaacagga gctttattgc agaaatgacc      780

atttatatca agcagctggg cagaaggatt tttgcacgag aacatggatc aaataagaaa      840

ttggcagcac agtcctgtgc cctgtcactt gtcagacaac tgtaccatct tggagtggtt      900

gaagcttact ccggacttac aaagaagaag gaaggagaga cagtggagcc ttacaaagta      960

aacctctctc aagatttaga gcatcagctg caaaacatca ttcaagagct aaatcttgag     1020

attttgcccc cgcctgaaga tccttctgtg ccagttgcac tcaacattgg caaattggct     1080

cagttcgaac catctcagcg acaaaaccaa gtgggtgtgg ttccttggtc acctccacaa     1140

tccaactgga atccttggac tagtagcaac attgatgagg ggcctctggc ttttgctact     1200

ccagagcaaa taagcatgga cctcaagaat gaattgatgt accagttgga acaggatcat     1260

gatttgcaag caatcttgca ggagagagag ttactgcctg tgaagaaatt tgaaagtgag     1320

attctggaag caatcagcca aaattcagtt gtcattatta gaggggctac tggatgtggg     1380

aaaaccacac aggttcccca gttcattcta gatgacttta tccagaatga ccgagcagca     1440

gagtgtaaca tcgtagtaac tcagcccaga agaatcagtg cggtttctgt ggcagagcga     1500

gttgcatttg aaagaggaga agagcctgga aaaagctgtg gctacagcgt tcgatttgag     1560

tctatacttc ctcgtcctca tgccagtata atgttttgta ctgtaggtgt gctcctgaga     1620

aaattagaag caggcattcg aggaatcagt catgtaattg tagatgaaat acatgaaaga     1680

gatattaata ctgacttcct tttggtagta ctgcgtgatg ttgttcaggc ttatcctgaa     1740

gttcgcattg ttcttatgtc tgctactatt gataccagca tgttttgtga atatttcttc     1800

aattgcccca tcattgaagt ttatgggagg acttacccag ttcaagaata ttttctggaa     1860

gactgcattc agatgaccca ctttgttcct ccaccaaaag acaaaaagaa gaaggataag     1920

gatgatgatg gtggtgagga tgatgatgca aattgcaact tgatctgtgg tgatgaatat     1980

ggtccagaaa caaggttgag catgtctcaa ttgaacgaaa aggaaactcc ttttgaactc     2040

atcgaggctc tacttaagta cattgaaacc cttaatgttc ctggagctgt gttggttttt     2100

ttgcctggct ggaatctgat ttatactatg cagaagcatt tggaaatgaa tccacatttt     2160

ggaagccatc ggtatcagat tctacccctg cattctcaga ttcctcgaga ggaacagcgc     2220

aaagtgtttg atccagtacc agttggagta accaaggtta ttttgtccac aaatattgct     2280

gaaacaagca ttaccataaa cgatgttgtt tatgtcattg actcctgcaa gcagaaagtg     2340

aaactcttca ctgctcacaa caatatgacc aactatgcta ccgtatgggc atcaaaaaca     2400

aaccttgagc aacggaaagg gcgagctggc cgagtacggc ctggattctg ctttcacctg     2460

tgcagccgag ctcgttttga gagacttgaa acccacatga caccagagat gttccgaaca     2520

ccattgcatg aaattgctct tagcataaaa cttctgcgtc taggaggaat tggccaattt     2580

ctggccaaag caattgaacc tccccctttg gatgctgtga ttgaagcaga acacactctt     2640

agagagcttg atgcattaga tgccaatgat gagttgactc ctttgggacg aatcctggct     2700

aaactcccca ttgagcctcg ttttggcaaa atgatgataa tggggtgtat tttctacgtg     2760

ggagatgcta tctgtaccat tgctgctgct acctgctttc cagagccttt catcaatgaa     2820

ggaaagcggc tgggctatat ccatcgaaat tttgctggaa acagattttc tgatcacgta     2880

gcccttttat cagtattcca agcctgggat gatgctagaa tgggtggaga agaagcagag     2940

atacgttttt gtgagcacaa aagacttaat atggctacac taagaatgac ttgggaagcc     3000

aaagttcagc tcaaagagat tttgattaat tctgggtttc cagaagattg tttgttgaca     3060

caagtgttta ctaacactgg accagataat aatttggatg ttgttatctc cctcctggcc     3120

tttggtgtgt accccaatgt atgctatcat aaggaaaaga ggaagattct caccactgaa     3180

gggcgtaatg cacttatcca caaatcatct gttaattgtc cttttagtag ccaagacatg     3240

aagtacccat ctcccttctt tgtatttggt gaaaagattc gaactcgagc catctctgct     3300

aaaggcatga ctttagtcac ccccctgcag ttgcttctct ttgcctccaa gaaagtccaa     3360

tctgatgggc agattgtgct tgtagatgac tggattaaac tgcaaatatc tcatgaagct     3420

gctgcctgta tcactggtct ccgggcagcc atggaggctt tggttgttga agtaaccaaa     3480

caacctgcta tcatcagcca gttggacccc gtaaatgaac gtatgctgaa catgatccgt     3540

cagatctcta gaccctcagc tgctggtatc aaccttatga ttggcagtac acggtatgga     3600

gatggtccac gtcctcccaa gatggcccga tacgacaatg gaagcggata tagaagggga     3660

ggttctagtt acagtggtgg aggctatggc ggtggctata gcagtggagg ctatggtagc     3720

ggaggctatg gtggcagcgc caactccttt cgggcaggat atggtgcagg tgttggtgga     3780

ggctatagag gagtttcccg aggtggcttt agaggcaact ctggaggaga ctacagaggg     3840

cctagtggag gctacagagg atctggggga ttccagcgag gaggtggtag gggggcctat     3900

ggaactggct actttggaca gggaagagga ggtggcggct attaaaactt ggttatgtca     3960

gttcctgtgt gtagacagta aggaaaaaaa ggcatgctat gtgttacgtg ttttttccag     4020

tatgtttatt tgccaccaaa aagtaaatgc attttcaccc attctgtggt tcattgtagt     4080

ttaaggaaac caagcatata gatgcattag tgattttgtt tatattatgt aaaatataac     4140

gatctcttaa aaataccaca gtttgtattt tttctttaag gagtaaagat ttgcctttaa     4200

ataacttggt attttcctgg ctttcgttta atacaataga aaataaagta ttacaccgaa     4260

tacttgccgt gtagtttgtt tgttgacctc gtatgttaga aaattttaca atgccagcta     4320

catctgttga ttttaaatgt cagagaagtt gtaccctgtt tcaaaagtat actaagtgat     4380

actacttgta atagaataaa tcatcttgga attgaattgt taccttttga agtaaatact     4440

ggcaagtgca caagccacat aaacctgaat aaaacttttg acctagggtt gaa            4493


<210>  34
<211>  1270
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Gly Val Tyr  Pro Asn Val Cys Tyr  His Lys Glu 
        995                 1000                 1005             


Lys Arg  Lys Ile Leu Thr Thr  Glu Gly Arg Asn Ala  Leu Ile His 
    1010                 1015                 1020             


Lys Ser  Ser Val Asn Cys Pro  Phe Ser Ser Gln Asp  Met Lys Tyr 
    1025                 1030                 1035             


Pro Ser  Pro Phe Phe Val Phe  Gly Glu Lys Ile Arg  Thr Arg Ala 
    1040                 1045                 1050             


Ile Ser  Ala Lys Gly Met Thr  Leu Val Thr Pro Leu  Gln Leu Leu 
    1055                 1060                 1065             


Leu Phe  Ala Ser Lys Lys Val  Gln Ser Asp Gly Gln  Ile Val Leu 
    1070                 1075                 1080             


Val Asp  Asp Trp Ile Lys Leu  Gln Ile Ser His Glu  Ala Ala Ala 
    1085                 1090                 1095             


Cys Ile  Thr Gly Leu Arg Ala  Ala Met Glu Ala Leu  Val Val Glu 
    1100                 1105                 1110             


Val Thr  Lys Gln Pro Ala Ile  Ile Ser Gln Leu Asp  Pro Val Asn 
    1115                 1120                 1125             


Glu Arg  Met Leu Asn Met Ile  Arg Gln Ile Ser Arg  Pro Ser Ala 
    1130                 1135                 1140             


Ala Gly  Ile Asn Leu Met Ile  Gly Ser Thr Arg Tyr  Gly Asp Gly 
    1145                 1150                 1155             


Pro Arg  Pro Pro Lys Met Ala  Arg Tyr Asp Asn Gly  Ser Gly Tyr 
    1160                 1165                 1170             


Arg Arg  Gly Gly Ser Ser Tyr  Ser Gly Gly Gly Tyr  Gly Gly Gly 
    1175                 1180                 1185             


Tyr Ser  Ser Gly Gly Tyr Gly  Ser Gly Gly Tyr Gly  Gly Ser Ala 
    1190                 1195                 1200             


Asn Ser  Phe Arg Ala Gly Tyr  Gly Ala Gly Val Gly  Gly Gly Tyr 
    1205                 1210                 1215             


Arg Gly  Val Ser Arg Gly Gly  Phe Arg Gly Asn Ser  Gly Gly Asp 
    1220                 1225                 1230             


Tyr Arg  Gly Pro Ser Gly Gly  Tyr Arg Gly Ser Gly  Gly Phe Gln 
    1235                 1240                 1245             


Arg Gly  Gly Gly Arg Gly Ala  Tyr Gly Thr Gly Tyr  Phe Gly Gln 
    1250                 1255                 1260             


Gly Arg  Gly Gly Gly Gly Tyr  
    1265                 1270 


<210>  35
<211>  3069
<212>  DNA
<213>  Homo sapiens

<400>  35
gagtgtcggg cgcggcagga ggacgaggca gggcgggcgg gcgctctaag ggttctgctc       60

tgactccagg ttgggacagc gtcttcgctg ctgctggata gtcgtgtttt cggggatcga      120

ggatactcac cagaaaccga aaatgccgaa accaatcaat gtccgagtta ccaccatgga      180

tgcagagctg gagtttgcaa tccagccaaa tacaactgga aaacagcttt ttgatcaggt      240

ggtaaagact atcggcctcc gggaagtgtg gtactttggc ctccactatg tggataataa      300

aggatttcct acctggctga agctggataa gaaggtgtct gcccaggagg tcaggaagga      360

gaatcccctc cagttcaagt tccgggccaa gttctaccct gaagatgtgg ctgaggagct      420

catccaggac atcacccaga aacttttctt cctccaagtg aaggaaggaa tccttagcga      480

tgagatctac tgcccccctg agactgccgt gctcttgggg tcctacgctg tgcaggccaa      540

gtttggggac tacaacaaag aagtgcacaa gtctgggtac ctcagctctg agcggctgat      600

ccctcaaaga gtgatggacc agcacaaact taccagggac cagtgggagg accggatcca      660

ggtgtggcat gcggaacacc gtgggatgct caaagataat gctatgttgg aatacctgaa      720

gattgctcag gacctggaaa tgtatggaat caactatttc gagataaaaa acaagaaagg      780

aacagacctt tggcttggag ttgatgccct tggactgaat atttatgaga aagatgataa      840

gttaacccca aagattggct ttccttggag tgaaatcagg aacatctctt tcaatgacaa      900

aaagtttgtc attaaaccca tcgacaagaa ggcacctgac tttgtgtttt atgccccacg      960

tctgagaatc aacaagcgga tcctgcagct ctgcatgggc aaccatgagt tgtatatgcg     1020

ccgcaggaag cctgacacca tcgaggtgca gcagatgaag gcccaggccc gggaggagaa     1080

gcatcagaag cagctggagc ggcaacagct ggaaacagag aagaaaagga gagaaaccgt     1140

ggagagagag aaagagcaga tgatgcgcga gaaggaggag ttgatgctgc ggctgcagga     1200

ctatgaggag aagacaaaga aggcagagag agagctctcg gagcagattc agagggccct     1260

gcagctggag gaggagagga agcgggcaca ggaggaggcc gagcgcctag aggctgaccg     1320

tatggctgca ctgcgggcta aggaggagct ggagagacag gcggtggatc agataaagag     1380

ccaggagcag ctggctgcgg agcttgcaga atacactgcc aagattgccc tcctggaaga     1440

ggcgcggagg cgcaaggagg atgaagttga agagtggcag cacagggcca aagaagccca     1500

ggatgacctg gtgaagacca aggaggagct gcacctggtg atgacagcac ccccgccccc     1560

accacccccc gtgtacgagc cggtgagcta ccatgtccag gagagcttgc aggatgaggg     1620

cgcagagccc acgggctaca gcgcggagct gtctagtgag ggcatccggg atgaccgcaa     1680

tgaggagaag cgcatcactg aggcagagaa gaacgagcgt gtgcagcggc agctgctgac     1740

gctgagcagc gagctgtccc aggcccgaga tgagaataag aggacccaca atgacatcat     1800

ccacaacgag aacatgaggc aaggccggga caagtacaag acgctgcggc agatccggca     1860

gggcaacacc aagcagcgca tcgacgagtt cgaggccctg taacagccag gccaggacca     1920

agggcagagg ggtgctcata gcgggcgctg ccagccccgc cacgcttgtg tctttagtgc     1980

tccaagtcta ggaactccct cagatcccag ttcctttaga aagcagttac ccaacagaaa     2040

cattctgggc tgggaaccag ggaggcgccc tggtttgttt tccccagttg taatagtgcc     2100

aagcaggcct gattctcgcg attattctcg aatcacctcc tgtgttgtgc tgggagcagg     2160

actgattgaa ttacggaaaa tgcctgtaaa gtctgagtaa gaaacttcat gctggcctgt     2220

gtgatacaag agtcagcatc attaaaggaa acgtggcagg acttccatct gtgccatact     2280

tgttctgtat tcgaaatgag ctcaaattga ttttttaatt tctatgaagg atccatcttt     2340

gtatatttac atgcttagag gggtgaaaat tattttggaa attgagtctg aagcactctc     2400

gcacacacag tgattccctc ctcccgtcac tccacgcagc tggcagagag cacagtgatc     2460

accagcgtga gtggtggagg aggacacttg gatttttttt tttgtttttt ttttttttgc     2520

ttaacagttt tagaatacat tgtacttata caccttatta atgatcagct atatactatt     2580

tatatacaag tgataataca gatttgtaac attagtttta aaaagggaaa gttttgttct     2640

gtatattttg ttacctttta cagaataaaa gaattacata tgaaaaaccc tctaaaccat     2700

ggcacttgat gtgatgtggc aggagggcag tggtggagct ggacctgcct gctgcagtca     2760

cgtgtaaaca ggattattat tagtgtttta tgcatgtaat ggactatgca cacttttaat     2820

tttgtcagat tcacacatgc cactatgagc tttcagactc cagctgtgaa gagactctgt     2880

ttgcttgtgt ttgtttgttt gcagtctctc tctgccatgg ccttggcagg ctgctggaag     2940

gcagcttgtg gaggccgttg gttccgccca ctcattcctt ctcgtgcact gctttctcct     3000

tcacagctaa gatgccatgt gcaggtggat tccatgccgc agacatgaaa taaaagcttt     3060

gcaaaggca                                                             3069


<210>  36
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 
        35                  40                  45              


Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 
    50                  55                  60                  


Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln 
145                 150                 155                 160 


His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 
                165                 170                 175     


Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu 
                325                 330                 335     


Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln 
            340                 345                 350         


Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln 
        355                 360                 365             


Ile Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu 
    370                 375                 380                 


Glu Ala Glu Arg Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys 
385                 390                 395                 400 


Glu Glu Leu Glu Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln 
                405                 410                 415     


Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu 
            420                 425                 430         


Glu Ala Arg Arg Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg 
        435                 440                 445             


Ala Lys Glu Ala Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His 
    450                 455                 460                 


Leu Val Met Thr Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro 
465                 470                 475                 480 


Val Ser Tyr His Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro 
                485                 490                 495     


Thr Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg 
            500                 505                 510         


Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln 
        515                 520                 525             


Arg Gln Leu Leu Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu 
    530                 535                 540                 


Asn Lys Arg Thr His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln 
545                 550                 555                 560 


Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr 
                565                 570                 575     


Lys Gln Arg Ile Asp Glu Phe Glu Ala Leu 
            580                 585     


<210>  37
<211>  3628
<212>  DNA
<213>  Homo sapiens

<400>  37
agagcatcag caagagtagc agcgagcagc cgcgctggtg gcggcggcgc gtcgttgcag       60

ttgcgccatc tgtcaggagc ggagccggcg aggagggggc tgccgcgggc gaggaggagg      120

ggtcgccgcg agccgaaggc cttcgagacc cgcccgccgc ccggcggcga gagtagaggc      180

gaggttgttg tgcgagcggc gcgtcctctc ccgcccgggc gcgccgcgct tctcccagcg      240

caccgaggac cgcccgggcg cacacaaagc cgccgcccgc gccgcaccgc ccggcggccg      300

ccgcccgcgc cagggaggga ttcggccgcc gggccgggga caccccggcg ccgccccctc      360

ggtgctctcg gaaggcccac cggctcccgg gcccgccggg gaccccccgg agccgcctcg      420

gccgcgccgg aggagggcgg ggagaggacc atgtgagtgg gctccggagc ctcagcgccg      480

cgcagttttt ttgaagaagc aggatgctga tctaaacgtg gaaaaagacc agtcctgcct      540

ctgttgtaga agacatgtgg tgtatataaa gtttgtgatc gttggcggac attttggaat      600

ttagataatg ggctgtgtgc aatgtaagga taaagaagca acaaaactga cggaggagag      660

ggacggcagc ctgaaccaga gctctgggta ccgctatggc acagacccca cccctcagca      720

ctaccccagc ttcggtgtga cctccatccc caactacaac aacttccacg cagccggggg      780

ccaaggactc accgtctttg gaggtgtgaa ctcttcgtct catacgggga ccttgcgtac      840

gagaggagga acaggagtga cactctttgt ggccctttat gactatgaag cacggacaga      900

agatgacctg agttttcaca aaggagaaaa atttcaaata ttgaacagct cggaaggaga      960

ttggtgggaa gcccgctcct tgacaactgg agagacaggt tacattccca gcaattatgt     1020

ggctccagtt gactctatcc aggcagaaga gtggtacttt ggaaaacttg gccgaaaaga     1080

tgctgagcga cagctattgt cctttggaaa cccaagaggt acctttctta tccgcgagag     1140

tgaaaccacc aaaggtgcct attcactttc tatccgtgat tgggatgata tgaaaggaga     1200

ccatgtcaaa cattataaaa ttcgcaaact tgacaatggt ggatactaca ttaccacccg     1260

ggcccagttt gaaacacttc agcagcttgt acaacattac tcagagagag ctgcaggtct     1320

ctgctgccgc ctagtagttc cctgtcacaa agggatgcca aggcttaccg atctgtctgt     1380

caaaaccaaa gatgtctggg aaatccctcg agaatccctg cagttgatca agagactggg     1440

aaatgggcag tttggggaag tatggatggg tacctggaat ggaaacacaa aagtagccat     1500

aaagactctt aaaccaggca caatgtcccc cgaatcattc cttgaggaag cgcagatcat     1560

gaagaagctg aagcacgaca agctggtcca gctctatgca gtggtgtctg aggagcccat     1620

ctacatcgtc accgagtata tgaacaaagg aagtttactg gatttcttaa aagatggaga     1680

aggaagagct ctgaaattac caaatcttgt ggacatggca gcacaggtgg ctgcaggaat     1740

ggcttacatc gagcgcatga attatatcca tagagatctg cgatcagcaa acattctagt     1800

ggggaatgga ctcatatgca agattgctga cttcggattg gcccgattga tagaagacaa     1860

tgagtacaca gcaagacaag gtgcaaagtt ccccatcaag tggacggccc ccgaggcagc     1920

cctgtacggg aggttcacaa tcaagtctga cgtgtggtct tttggaatct tactcacaga     1980

gctggtcacc aaaggaagag tgccataccc aggcatgaac aaccgggagg tgctggagca     2040

ggtggagcga ggctacagga tgccctgccc gcaggactgc cccatctctc tgcatgagct     2100

catgatccac tgctggaaaa aggaccctga agaacgcccc acttttgagt acttgcagag     2160

cttcctggaa gactacttta ccgcgacaga gccccagtac caacctggtg aaaacctgta     2220

aggcccgggt ctgcggagag aggccttgtc ccagaggctg ccccacccct ccccattagc     2280

tttcaattcc gtagccagct gctccccagc agcggaaccg cccaggatca gattgcatgt     2340

gactctgaag ctgacgaact tccatggccc tcattaatga cacttgtccc caaatccgaa     2400

cctcctctgt gaagcattcg agacagaacc ttgttatttc tcagactttg gaaaatgcat     2460

tgtatcgatg ttatgtaaaa ggccaaacct ctgttcagtg taaatagtta ctccagtgcc     2520

aacaatccta gtgctttcct tttttaaaaa tgcaaatcct atgtgatttt aactctgtct     2580

tcacctgatt caactaaaaa aaaaaaagta ttattttcca aaagtggcct ctttgtctaa     2640

aacaataaaa ttttttttca tgttttaaca aaaaccaatc aggacaggtg tttgtttttg     2700

ttttcttttt tataaatatg aatatatata atatatatgt ccctgtacat atacaatgtg     2760

ggtgctaatg tggagactgt ggccggcctg agccaccaag ctgcgggacc cagagggagg     2820

attttactgc aagtcagcat caaagcaccg gtgttattct gaaaacacca gtggcctcat     2880

ttttggcttt tgcaaagcat gaattttttc atttggattg cactttcctg gttcatgact     2940

gtacctgtag gtggttgtta ctttgactct tttcaggaac caccccccaa gctgaattta     3000

caagttctgt tagcactatt tgcttcaact tactgcgatt tgttctcaaa acttaaaaat     3060

aagcaagcaa atggctgata ctaccaagag aactggaaga tggataccac acaaacttct     3120

tgtataaaaa tatgaatgct gaaatgtttc agacattttt aatttaataa acctgtaacc     3180

acatttaagt gatctaaaac ccatagcatt gtagtcatgg caacccgcta aactttctca     3240

tgcaactaaa atttctgggg gaaatgaggg tgggggttgt acatttccca ttgtaaaata     3300

agtgttttaa atgtcctgta ctgctaacga atgactttct atatgtccag gagttctcca     3360

gtggaataac tatgcactac tttacatttc atggggatgc acaaaaacaa aaaagtatta     3420

catttttagt tgctgtttgt accaacctta aattacatat gtttaacaac aacaaatcaa     3480

aaatcctatt tctattgagt ttttaatact gactagcaac tctgaagtct taattccttt     3540

tttgttatga tttatttgtg agtttacatt tttaaattgt ttaactttct taatttagta     3600

attaaaaaga gagcatttta catttgaa                                        3628


<210>  38
<211>  3238
<212>  DNA
<213>  Homo sapiens

<400>  38
ggctcccggg cccgccgggg accccccgga gccgcctcgg ccgcgccgga ggagggcggg       60

gagaggacca tgtgagtggg ctccggagcc tcagcgccgc gcagtttttt tgaagaagca      120

ggatgctgat ctaaacgtgg aaaaagacca gtcctgcctc tgttgtagaa gacatgtggt      180

gtatataaag tttgtgatcg ttggcggaca ttttggaatt tagataatgg gctgtgtgca      240

atgtaaggat aaagaagcaa caaaactgac ggaggagagg gacggcagcc tgaaccagag      300

ctctgggtac cgctatggca cagaccccac ccctcagcac taccccagct tcggtgtgac      360

ctccatcccc aactacaaca acttccacgc agccgggggc caaggactca ccgtctttgg      420

aggtgtgaac tcttcgtctc atacggggac cttgcgtacg agaggaggaa caggagtgac      480

actctttgtg gccctttatg actatgaagc acggacagaa gatgacctga gttttcacaa      540

aggagaaaaa tttcaaatat tgaacagctc ggaaggagat tggtgggaag cccgctcctt      600

gacaactgga gagacaggtt acattcccag caattatgtg gctccagttg actctatcca      660

ggcagaagag tggtactttg gaaaacttgg ccgaaaagat gctgagcgac agctattgtc      720

ctttggaaac ccaagaggta cctttcttat ccgcgagagt gaaaccacca aaggtgccta      780

ttcactttct atccgtgatt gggatgatat gaaaggagac catgtcaaac attataaaat      840

tcgcaaactt gacaatggtg gatactacat taccacccgg gcccagtttg aaacacttca      900

gcagcttgta caacattact cagagaaagc tgatggtttg tgttttaact taactgtgat      960

tgcatcgagt tgtaccccac aaacttctgg attggctaaa gatgcttggg aagttgcacg     1020

tcgttcgttg tgtctggaga agaagctggg tcaggggtgt ttcgctgaag tgtggcttgg     1080

tacctggaat ggaaacacaa aagtagccat aaagactctt aaaccaggca caatgtcccc     1140

cgaatcattc cttgaggaag cgcagatcat gaagaagctg aagcacgaca agctggtcca     1200

gctctatgca gtggtgtctg aggagcccat ctacatcgtc accgagtata tgaacaaagg     1260

aagtttactg gatttcttaa aagatggaga aggaagagct ctgaaattac caaatcttgt     1320

ggacatggca gcacaggtgg ctgcaggaat ggcttacatc gagcgcatga attatatcca     1380

tagagatctg cgatcagcaa acattctagt ggggaatgga ctcatatgca agattgctga     1440

cttcggattg gcccgattga tagaagacaa tgagtacaca gcaagacaag gtgcaaagtt     1500

ccccatcaag tggacggccc ccgaggcagc cctgtacggg aggttcacaa tcaagtctga     1560

cgtgtggtct tttggaatct tactcacaga gctggtcacc aaaggaagag tgccataccc     1620

aggcatgaac aaccgggagg tgctggagca ggtggagcga ggctacagga tgccctgccc     1680

gcaggactgc cccatctctc tgcatgagct catgatccac tgctggaaaa aggaccctga     1740

agaacgcccc acttttgagt acttgcagag cttcctggaa gactacttta ccgcgacaga     1800

gccccagtac caacctggtg aaaacctgta aggcccgggt ctgcggagag aggccttgtc     1860

ccagaggctg ccccacccct ccccattagc tttcaattcc gtagccagct gctccccagc     1920

agcggaaccg cccaggatca gattgcatgt gactctgaag ctgacgaact tccatggccc     1980

tcattaatga cacttgtccc caaatccgaa cctcctctgt gaagcattcg agacagaacc     2040

ttgttatttc tcagactttg gaaaatgcat tgtatcgatg ttatgtaaaa ggccaaacct     2100

ctgttcagtg taaatagtta ctccagtgcc aacaatccta gtgctttcct tttttaaaaa     2160

tgcaaatcct atgtgatttt aactctgtct tcacctgatt caactaaaaa aaaaaaagta     2220

ttattttcca aaagtggcct ctttgtctaa aacaataaaa ttttttttca tgttttaaca     2280

aaaaccaatc aggacaggtg tttgtttttg ttttcttttt tataaatatg aatatatata     2340

atatatatgt ccctgtacat atacaatgtg ggtgctaatg tggagactgt ggccggcctg     2400

agccaccaag ctgcgggacc cagagggagg attttactgc aagtcagcat caaagcaccg     2460

gtgttattct gaaaacacca gtggcctcat ttttggcttt tgcaaagcat gaattttttc     2520

atttggattg cactttcctg gttcatgact gtacctgtag gtggttgtta ctttgactct     2580

tttcaggaac caccccccaa gctgaattta caagttctgt tagcactatt tgcttcaact     2640

tactgcgatt tgttctcaaa acttaaaaat aagcaagcaa atggctgata ctaccaagag     2700

aactggaaga tggataccac acaaacttct tgtataaaaa tatgaatgct gaaatgtttc     2760

agacattttt aatttaataa acctgtaacc acatttaagt gatctaaaac ccatagcatt     2820

gtagtcatgg caacccgcta aactttctca tgcaactaaa atttctgggg gaaatgaggg     2880

tgggggttgt acatttccca ttgtaaaata agtgttttaa atgtcctgta ctgctaacga     2940

atgactttct atatgtccag gagttctcca gtggaataac tatgcactac tttacatttc     3000

atggggatgc acaaaaacaa aaaagtatta catttttagt tgctgtttgt accaacctta     3060

aattacatat gtttaacaac aacaaatcaa aaatcctatt tctattgagt ttttaatact     3120

gactagcaac tctgaagtct taattccttt tttgttatga tttatttgtg agtttacatt     3180

tttaaattgt ttaactttct taatttagta attaaaaaga gagcatttta catttgaa       3238


<210>  39
<211>  2959
<212>  DNA
<213>  Homo sapiens

<400>  39
aaatgatcaa gtgttgggta taagccaagg agctgagaga gggggagacc agcgcaggtc       60

tgaggagctg agaagggagg cttacgtgaa gggaatttag ataatgggct gtgtgcaatg      120

taaggataaa gaagcaacaa aactgacgga ggagagggac ggcagcctga accagagctc      180

tgggtaccgc tatggcacag accccacccc tcagcactac cccagcttcg gtgtgacctc      240

catccccaac tacaacaact tccacgcagc cgggggccaa ggactcaccg tctttggagg      300

tgtgaactct tcgtctcata cggggacctt gcgtacgaga ggaggaacag gagtgacact      360

ctttgtggcc ctttatgact atgaagcacg gacagaagat gacctgagtt ttcacaaagg      420

agaaaaattt caaatattga acagctcgga aggagattgg tgggaagccc gctccttgac      480

aactggagag acaggttaca ttcccagcaa ttatgtggct ccagttgact ctatccaggc      540

agaagagtgg tactttggaa aacttggccg aaaagatgct gagcgacagc tattgtcctt      600

tggaaaccca agaggtacct ttcttatccg cgagagtgaa accaccaaag gtgcctattc      660

actttctatc cgtgattggg atgatatgaa aggagaccat gtcaaacatt ataaaattcg      720

caaacttgac aatggtggat actacattac cacccgggcc cagtttgaaa cacttcagca      780

gcttgtacaa cattactcag gtacctggaa tggaaacaca aaagtagcca taaagactct      840

taaaccaggc acaatgtccc ccgaatcatt ccttgaggaa gcgcagatca tgaagaagct      900

gaagcacgac aagctggtcc agctctatgc agtggtgtct gaggagccca tctacatcgt      960

caccgagtat atgaacaaag gaagtttact ggatttctta aaagatggag aaggaagagc     1020

tctgaaatta ccaaatcttg tggacatggc agcacaggtg gctgcaggaa tggcttacat     1080

cgagcgcatg aattatatcc atagagatct gcgatcagca aacattctag tggggaatgg     1140

actcatatgc aagattgctg acttcggatt ggcccgattg atagaagaca atgagtacac     1200

agcaagacaa ggtgcaaagt tccccatcaa gtggacggcc cccgaggcag ccctgtacgg     1260

gaggttcaca atcaagtctg acgtgtggtc ttttggaatc ttactcacag agctggtcac     1320

caaaggaaga gtgccatacc caggcatgaa caaccgggag gtgctggagc aggtggagcg     1380

aggctacagg atgccctgcc cgcaggactg ccccatctct ctgcatgagc tcatgatcca     1440

ctgctggaaa aaggaccctg aagaacgccc cacttttgag tacttgcaga gcttcctgga     1500

agactacttt accgcgacag agccccagta ccaacctggt gaaaacctgt aaggcccggg     1560

tctgcggaga gaggccttgt cccagaggct gccccacccc tccccattag ctttcaattc     1620

cgtagccagc tgctccccag cagcggaacc gcccaggatc agattgcatg tgactctgaa     1680

gctgacgaac ttccatggcc ctcattaatg acacttgtcc ccaaatccga acctcctctg     1740

tgaagcattc gagacagaac cttgttattt ctcagacttt ggaaaatgca ttgtatcgat     1800

gttatgtaaa aggccaaacc tctgttcagt gtaaatagtt actccagtgc caacaatcct     1860

agtgctttcc ttttttaaaa atgcaaatcc tatgtgattt taactctgtc ttcacctgat     1920

tcaactaaaa aaaaaaaagt attattttcc aaaagtggcc tctttgtcta aaacaataaa     1980

attttttttc atgttttaac aaaaaccaat caggacaggt gtttgttttt gttttctttt     2040

ttataaatat gaatatatat aatatatatg tccctgtaca tatacaatgt gggtgctaat     2100

gtggagactg tggccggcct gagccaccaa gctgcgggac ccagagggag gattttactg     2160

caagtcagca tcaaagcacc ggtgttattc tgaaaacacc agtggcctca tttttggctt     2220

ttgcaaagca tgaatttttt catttggatt gcactttcct ggttcatgac tgtacctgta     2280

ggtggttgtt actttgactc ttttcaggaa ccacccccca agctgaattt acaagttctg     2340

ttagcactat ttgcttcaac ttactgcgat ttgttctcaa aacttaaaaa taagcaagca     2400

aatggctgat actaccaaga gaactggaag atggatacca cacaaacttc ttgtataaaa     2460

atatgaatgc tgaaatgttt cagacatttt taatttaata aacctgtaac cacatttaag     2520

tgatctaaaa cccatagcat tgtagtcatg gcaacccgct aaactttctc atgcaactaa     2580

aatttctggg ggaaatgagg gtgggggttg tacatttccc attgtaaaat aagtgtttta     2640

aatgtcctgt actgctaacg aatgactttc tatatgtcca ggagttctcc agtggaataa     2700

ctatgcacta ctttacattt catggggatg cacaaaaaca aaaaagtatt acatttttag     2760

ttgctgtttg taccaacctt aaattacata tgtttaacaa caacaaatca aaaatcctat     2820

ttctattgag tttttaatac tgactagcaa ctctgaagtc ttaattcctt ttttgttatg     2880

atttatttgt gagtttacat ttttaaattg tttaactttc ttaatttagt aattaaaaag     2940

agagcatttt acatttgaa                                                  2959


<210>  40
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210>  41
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Lys Ala Asp Gly Leu Cys Phe 
225                 230                 235                 240 


Asn Leu Thr Val Ile Ala Ser Ser Cys Thr Pro Gln Thr Ser Gly Leu 
                245                 250                 255     


Ala Lys Asp Ala Trp Glu Val Ala Arg Arg Ser Leu Cys Leu Glu Lys 
            260                 265                 270         


Lys Leu Gly Gln Gly Cys Phe Ala Glu Val Trp Leu Gly Thr Trp Asn 
        275                 280                 285             


Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met Ser 
    290                 295                 300                 


Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys Leu Lys His 
305                 310                 315                 320 


Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr 
                325                 330                 335     


Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp Phe Leu Lys 
            340                 345                 350         


Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val Asp Met Ala 
        355                 360                 365             


Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met Asn Tyr Ile 
    370                 375                 380                 


His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn Gly Leu Ile 
385                 390                 395                 400 


Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu 
                405                 410                 415     


Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro 
            420                 425                 430         


Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser 
        435                 440                 445             


Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg Val Pro Tyr 
    450                 455                 460                 


Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu Arg Gly Tyr 
465                 470                 475                 480 


Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His Glu Leu Met 
                485                 490                 495     


Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr 
            500                 505                 510         


Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu Pro Gln Tyr 
        515                 520                 525             


Gln Pro Gly Glu Asn Leu 
    530                 


<210>  42
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Gly Thr Trp Asn Gly Asn Thr Lys 
225                 230                 235                 240 


Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met Ser Pro Glu Ser Phe 
                245                 250                 255     


Leu Glu Glu Ala Gln Ile Met Lys Lys Leu Lys His Asp Lys Leu Val 
            260                 265                 270         


Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu 
        275                 280                 285             


Tyr Met Asn Lys Gly Ser Leu Leu Asp Phe Leu Lys Asp Gly Glu Gly 
    290                 295                 300                 


Arg Ala Leu Lys Leu Pro Asn Leu Val Asp Met Ala Ala Gln Val Ala 
305                 310                 315                 320 


Ala Gly Met Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu 
                325                 330                 335     


Arg Ser Ala Asn Ile Leu Val Gly Asn Gly Leu Ile Cys Lys Ile Ala 
            340                 345                 350         


Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg 
        355                 360                 365             


Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu 
    370                 375                 380                 


Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu 
385                 390                 395                 400 


Leu Thr Glu Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Asn 
                405                 410                 415     


Asn Arg Glu Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys 
            420                 425                 430         


Pro Gln Asp Cys Pro Ile Ser Leu His Glu Leu Met Ile His Cys Trp 
        435                 440                 445             


Lys Lys Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe 
    450                 455                 460                 


Leu Glu Asp Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu 
465                 470                 475                 480 


Asn Leu 
        


<210>  43
<211>  2750
<212>  DNA
<213>  Homo sapiens

<400>  43
attgtttcct actccatttt ctctggggca atagcagaat aggagcaagc cagcactagt       60

cagctaacta agtgactcaa ccaaggcctt ttttccttgt tatctttgca gatacttcat      120

tttcttagcg tttctggaga ttacaacatc ctgcggttcc gtttctggga actttactga      180

tttatctccc ccctcacaca aataagcatt gattcctgca tttctgaaga tctcaagatc      240

tggactactg ttgaaaaaat ttccagtgag gctcacttat gtctgtaaag atgggaaaaa      300

aatacaagaa cattgttcta ctaaaaggat tagaggtcat caatgattat cattttagaa      360

tggttaagtc cttactgagc aacgatttaa aacttaattt aaaaatgaga gaagagtatg      420

acaaaattca gattgctgac ttgatggaag aaaagttccg aggtgatgct ggtttgggca      480

aactaataaa aattttcgaa gatataccaa cgcttgaaga cctggctgaa actcttaaaa      540

aagaaaagtt aaaagtaaaa ggaccagccc tatcaagaaa gaggaagaag gaagtggatg      600

ctacttcacc tgcaccctcc acaagcagca ctgtcaaaac tgaaggagca gaggcaactc      660

ctggagctca gaaaagaaaa aaatcaacca aagaaaaggc tggacccaaa gggagtaagg      720

tgtccgagga acagactcag cctccctctc ctgcaggagc cggcatgtcc acagccatgg      780

gccgttcccc atctcccaag acctcattgt cagctccacc caacagttct tcaactgaga      840

acccgaaaac agtggccaaa tgtcaggtaa ctcccagaag aaatgttctc caaaaacgcc      900

cagtgatagt gaaggtactg agtacaacaa agccatttga atatgagacc ccagaaatgg      960

agaaaaaaat aatgtttcat gctacagtgg ctacacagac acagttcttc catgtgaagg     1020

ttttaaacac cagcttgaag gagaaattca atggaaagaa aatcatcatc atatcagatt     1080

atttggaata tgatagtctc ctagaggtca atgaagaatc tactgtatct gaagctggtc     1140

ctaaccaaac gtttgaggtt ccaaataaaa tcatcaacag agcaaaggaa actctgaaga     1200

ttgatattct tcacaaacaa gcttcaggaa atattgtata tggggtattt atgctacata     1260

agaaaacagt aaatcagaag accacaatct acgaaattca ggatgataga ggaaaaatgg     1320

atgtagtggg gacaggacaa tgtcacaata tcccctgtga agaaggagat aagctccaac     1380

ttttctgctt tcgacttaga aaaaagaacc agatgtcaaa actgatttca gaaatgcata     1440

gttttatcca gataaagaaa aaaacaaacc cgagaaacaa tgaccccaag agcatgaagc     1500

taccccagga acagcgtcag cttccatatc cttcagaggc cagcacaacc ttccctgaga     1560

gccatcttcg gactcctcag atgccaccaa caactccatc cagcagtttc ttcaccaaga     1620

aaagtgaaga cacaatctcc aaaatgaatg acttcatgag gatgcagata ctgaaggaag     1680

ggagtcattt tccaggaccg ttcatgacca gcataggccc agctgagagc catccccaca     1740

ctcctcagat gcctccatca acaccaagca gcagtttctt aaccacgttg aaaccaagac     1800

tgaagactga acctgaagaa gtttccatag aagacagtgc ccagagtgac ctcaaagaag     1860

tgatggtgct gaacgcaaca gaatcatttg tatatgagcc caaagagcag aagaaaatgt     1920

ttcatgccac agtggcaact gagaatgaag tcttccgagt gaaggttttt aatattgacc     1980

taaaggagaa gttcacccca aagaagatca ttgccatagc aaattatgtt tgccgcaatg     2040

ggttcctgga ggtatatcct ttcacacttg tggctgatgt gaatgctgac cgaaacatgg     2100

agatcccaaa aggattgatt agaagtgcca gcgtaactcc taaaatcaat cagctttgct     2160

cacaaactaa aggaagtttt gtgaatgggg tgtttgaggt acataagaaa aatgtaaggg     2220

gtgaattcac ttattatgaa atacaagata atacagggaa gatggaagtg gtggtgcatg     2280

gacgactgac cacaatcaac tgtgaggaag gagataaact gaaactcacc tgctttgaat     2340

tggcaccgaa aagtgggaat accggggagt tgagatctgt aattcatagt cacatcaagg     2400

tcatcaagac caggaaaaac aagaaagaca tactcaatcc tgattcaagt atggaaactt     2460

caccagactt tttcttctaa aatctggatg tcattgacga taatgtttat ggagataagg     2520

tctaagtgcc taaaaaaatg tacatatacc tggttgaaat acaacactat acatacacac     2580

caccatatat actagctgtt aatcctatgg aatggggtat tgggagtgct tttttaattt     2640

ttcatagttt ttttttaata aaatggcata ttttgcatct acaacttcta taatttgaaa     2700

aaataaataa acattatctt ttttgtgaaa ggaaaaaaaa aaaaaaaaaa                2750


<210>  44
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Lys 
        115                 120                 125             


Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys Gly Ser Lys Val 
    130                 135                 140                 


Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly Ala Gly Met Ser 
145                 150                 155                 160 


Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser Leu Ser Ala Pro 
                165                 170                 175     


Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val Ala Lys Cys Gln 
            180                 185                 190         


Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro Val Ile Val Lys 
        195                 200                 205             


Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr Pro Glu Met Glu 
    210                 215                 220                 


Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln Thr Gln Phe Phe 
225                 230                 235                 240 


His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys Phe Asn Gly Lys 
                245                 250                 255     


Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp Ser Leu Leu Glu 
            260                 265                 270         


Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro Asn Gln Thr Phe 
        275                 280                 285             


Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu Thr Leu Lys Ile 
    290                 295                 300                 


Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val Tyr Gly Val Phe 
305                 310                 315                 320 


Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr Ile Tyr Glu Ile 
                325                 330                 335     


Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr Gly Gln Cys His 
            340                 345                 350         


Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu Phe Cys Phe Arg 
        355                 360                 365             


Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser Glu Met His Ser 
    370                 375                 380                 


Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn Asn Asp Pro Lys 
385                 390                 395                 400 


Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro Tyr Pro Ser Glu 
                405                 410                 415     


Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Leu Lys Pro Arg Leu Lys Thr Glu Pro Glu Glu Val Ser 
            500                 505                 510         


Ile Glu Asp Ser Ala Gln Ser Asp Leu Lys Glu Val Met Val Leu Asn 
        515                 520                 525             


Ala Thr Glu Ser Phe Val Tyr Glu Pro Lys Glu Gln Lys Lys Met Phe 
    530                 535                 540                 


His Ala Thr Val Ala Thr Glu Asn Glu Val Phe Arg Val Lys Val Phe 
545                 550                 555                 560 


Asn Ile Asp Leu Lys Glu Lys Phe Thr Pro Lys Lys Ile Ile Ala Ile 
                565                 570                 575     


Ala Asn Tyr Val Cys Arg Asn Gly Phe Leu Glu Val Tyr Pro Phe Thr 
            580                 585                 590         


Leu Val Ala Asp Val Asn Ala Asp Arg Asn Met Glu Ile Pro Lys Gly 
        595                 600                 605             


Leu Ile Arg Ser Ala Ser Val Thr Pro Lys Ile Asn Gln Leu Cys Ser 
    610                 615                 620                 


Gln Thr Lys Gly Ser Phe Val Asn Gly Val Phe Glu Val His Lys Lys 
625                 630                 635                 640 


Asn Val Arg Gly Glu Phe Thr Tyr Tyr Glu Ile Gln Asp Asn Thr Gly 
                645                 650                 655     


Lys Met Glu Val Val Val His Gly Arg Leu Thr Thr Ile Asn Cys Glu 
            660                 665                 670         


Glu Gly Asp Lys Leu Lys Leu Thr Cys Phe Glu Leu Ala Pro Lys Ser 
        675                 680                 685             


Gly Asn Thr Gly Glu Leu Arg Ser Val Ile His Ser His Ile Lys Val 
    690                 695                 700                 


Ile Lys Thr Arg Lys Asn Lys Lys Asp Ile Leu Asn Pro Asp Ser Ser 
705                 710                 715                 720 


Met Glu Thr Ser Pro Asp Phe Phe Phe 
                725                 


<210>  45
<211>  3617
<212>  DNA
<213>  Homo sapiens

<400>  45
atcgaaacag aaaccaaagt caggcaaact ctgtaagaac tgcctgacag aaagctggac       60

tcaaagctcc tacccgagtg tgcagcagga tcgccccggt ccgggacccc aggcgcacac      120

cgcagagtcc aaagtgccgc gcctgccggc cgcacctgcc tgccgcggcc ccgcgcgccg      180

ccccgctgcc cacctgcccg cctgcccacc tgcccaggtg cgagtgcagc cccgcgcgcc      240

ggcctgagag ccctgtggac aacctcgtca ttgtcaggca cagagcggta gaccctgctt      300

ctctaagtgg gcagcggaca gcggcacgca catttcacct gtcccgcaga caacagcacc      360

atctgcttgg gagaaccctc tcccttctct gagaaagaaa gatgtcgaat gggtattcca      420

cagacgagaa tttccgctat ctcatctcgt gcttcagggc cagggtgaaa atgtacatcc      480

aggtggagcc tgtgctggac tacctgacct ttctgcctgc agaggtgaag gagcagattc      540

agaggacagt cgccacctcc gggaacatgc aggcagttga actgctgctg agcaccttgg      600

agaagggagt ctggcacctt ggttggactc gggaattcgt ggaggccctc cggagaaccg      660

gcagccctct ggccgcccgc tacatgaacc ctgagctcac ggacttgccc tctccatcgt      720

ttgagaacgc tcatgatgaa tatctccaac tgctgaacct ccttcagccc actctggtgg      780

acaagcttct agttagagac gtcttggata agtgcatgga ggaggaactg ttgacaattg      840

aagacagaaa ccggattgct gctgcagaaa acaatggaaa tgaatcaggt gtaagagagc      900

tactaaaaag gattgtgcag aaagaaaact ggttctctgc atttctgaat gttcttcgtc      960

aaacaggaaa caatgaactt gtccaagagt taacaggctc tgattgctca gaaagcaatg     1020

cagagattga gaatttatca caagttgatg gtcctcaagt ggaagagcaa cttctttcaa     1080

ccacagttca gccaaatctg gagaaggagg tctggggcat ggagaataac tcatcagaat     1140

catcttttgc agattcttct gtagtttcag aatcagacac aagtttggca gaaggaagtg     1200

tcagctgctt agatgaaagt cttggacata acagcaacat gggcagtgat tcaggcacca     1260

tgggaagtga ttcagatgaa gagaatgtgg cagcaagagc atccccggag ccagaactcc     1320

agctcaggcc ttaccaaatg gaagttgccc agccagcctt ggaagggaag aatatcatca     1380

tctgcctccc tacagggagt ggaaaaacca gagtggctgt ttacattgcc aaggatcact     1440

tagacaagaa gaaaaaagca tctgagcctg gaaaagttat agttcttgtc aataaggtac     1500

tgctagttga acagctcttc cgcaaggagt tccaaccatt tttgaagaaa tggtatcgtg     1560

ttattggatt aagtggtgat acccaactga aaatatcatt tccagaagtt gtcaagtcct     1620

gtgatattat tatcagtaca gctcaaatcc ttgaaaactc cctcttaaac ttggaaaatg     1680

gagaagatgc tggtgttcaa ttgtcagact tttccctcat tatcattgat gaatgtcatc     1740

acaccaacaa agaagcagtg tataataaca tcatgaggca ttatttgatg cagaagttga     1800

aaaacaatag actcaagaaa gaaaacaaac cagtgattcc ccttcctcag atactgggac     1860

taacagcttc acctggtgtt ggaggggcca cgaagcaagc caaagctgaa gaacacattt     1920

taaaactatg tgccaatctt gatgcattta ctattaaaac tgttaaagaa aaccttgatc     1980

aactgaaaaa ccaaatacag gagccatgca agaagtttgc cattgcagat gcaaccagag     2040

aagatccatt taaagagaaa cttctagaaa taatgacaag gattcaaact tattgtcaaa     2100

tgagtccaat gtcagatttt ggaactcaac cctatgaaca atgggccatt caaatggaaa     2160

aaaaagctgc aaaagaagga aatcgcaaag aacgtgtttg tgcagaacat ttgaggaagt     2220

acaatgaggc cctacaaatt aatgacacaa ttcgaatgat agatgcgtat actcatcttg     2280

aaactttcta taatgaagag aaagataaga agtttgcagt catagaagat gatagtgatg     2340

agggtggtga tgatgagtat tgtgatggtg atgaagatga ggatgattta aagaaacctt     2400

tgaaactgga tgaaacagat agatttctca tgactttatt ttttgaaaac aataaaatgt     2460

tgaaaaggct ggctgaaaac ccagaatatg aaaatgaaaa gctgaccaaa ttaagaaata     2520

ccataatgga gcaatatact aggactgagg aatcagcacg aggaataatc tttacaaaaa     2580

cacgacagag tgcatatgcg ctttcccagt ggattactga aaatgaaaaa tttgctgaag     2640

taggagtcaa agcccaccat ctgattggag ctggacacag cagtgagttc aaacccatga     2700

cacagaatga acaaaaagaa gtcattagta aatttcgcac tggaaaaata aatctgctta     2760

tcgctaccac agtggcagaa gaaggtctgg atattaaaga atgtaacatt gttatccgtt     2820

atggtctcgt caccaatgaa atagccatgg tccaggcccg tggtcgagcc agagctgatg     2880

agagcaccta cgtcctggtt gctcacagtg gttcaggagt tatcgaacat gagacagtta     2940

atgatttccg agagaagatg atgtataaag ctatacattg tgttcaaaat atgaaaccag     3000

aggagtatgc tcataagatt ttggaattac agatgcaaag tataatggaa aagaaaatga     3060

aaaccaagag aaatattgcc aagcattaca agaataaccc atcactaata actttccttt     3120

gcaaaaactg cagtgtgcta gcctgttctg gggaagatat ccatgtaatt gagaaaatgc     3180

atcacgtcaa tatgacccca gaattcaagg aactttacat tgtaagagaa aacaaagcac     3240

tgcaaaagaa gtgtgccgac tatcaaataa atggtgaaat catctgcaaa tgtggccagg     3300

cttggggaac aatgatggtg cacaaaggct tagatttgcc ttgtctcaaa ataaggaatt     3360

ttgtagtggt tttcaaaaat aattcaacaa agaaacaata caaaaagtgg gtagaattac     3420

ctatcacatt tcccaatctt gactattcag aatgctgttt atttagtgat gaggattagc     3480

acttgattga agattctttt aaaatactat cagttaaaca tttaatatga ttatgattaa     3540

tgtattcatt atgctacaga actgacataa gaatcaataa aatgattgtt ttactctgca     3600

aaaaaaaaaa aaaaaaa                                                    3617


<210>  46
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Asn Gly Tyr Ser Thr Asp Glu Asn Phe Arg Tyr Leu Ile Ser 
1               5                   10                  15      


Cys Phe Arg Ala Arg Val Lys Met Tyr Ile Gln Val Glu Pro Val Leu 
            20                  25                  30          


Asp Tyr Leu Thr Phe Leu Pro Ala Glu Val Lys Glu Gln Ile Gln Arg 
        35                  40                  45              


Thr Val Ala Thr Ser Gly Asn Met Gln Ala Val Glu Leu Leu Leu Ser 
    50                  55                  60                  


Thr Leu Glu Lys Gly Val Trp His Leu Gly Trp Thr Arg Glu Phe Val 
65                  70                  75                  80  


Glu Ala Leu Arg Arg Thr Gly Ser Pro Leu Ala Ala Arg Tyr Met Asn 
                85                  90                  95      


Pro Glu Leu Thr Asp Leu Pro Ser Pro Ser Phe Glu Asn Ala His Asp 
            100                 105                 110         


Glu Tyr Leu Gln Leu Leu Asn Leu Leu Gln Pro Thr Leu Val Asp Lys 
        115                 120                 125             


Leu Leu Val Arg Asp Val Leu Asp Lys Cys Met Glu Glu Glu Leu Leu 
    130                 135                 140                 


Thr Ile Glu Asp Arg Asn Arg Ile Ala Ala Ala Glu Asn Asn Gly Asn 
145                 150                 155                 160 


Glu Ser Gly Val Arg Glu Leu Leu Lys Arg Ile Val Gln Lys Glu Asn 
                165                 170                 175     


Trp Phe Ser Ala Phe Leu Asn Val Leu Arg Gln Thr Gly Asn Asn Glu 
            180                 185                 190         


Leu Val Gln Glu Leu Thr Gly Ser Asp Cys Ser Glu Ser Asn Ala Glu 
        195                 200                 205             


Ile Glu Asn Leu Ser Gln Val Asp Gly Pro Gln Val Glu Glu Gln Leu 
    210                 215                 220                 


Leu Ser Thr Thr Val Gln Pro Asn Leu Glu Lys Glu Val Trp Gly Met 
225                 230                 235                 240 


Glu Asn Asn Ser Ser Glu Ser Ser Phe Ala Asp Ser Ser Val Val Ser 
                245                 250                 255     


Glu Ser Asp Thr Ser Leu Ala Glu Gly Ser Val Ser Cys Leu Asp Glu 
            260                 265                 270         


Ser Leu Gly His Asn Ser Asn Met Gly Ser Asp Ser Gly Thr Met Gly 
        275                 280                 285             


Ser Asp Ser Asp Glu Glu Asn Val Ala Ala Arg Ala Ser Pro Glu Pro 
    290                 295                 300                 


Glu Leu Gln Leu Arg Pro Tyr Gln Met Glu Val Ala Gln Pro Ala Leu 
305                 310                 315                 320 


Glu Gly Lys Asn Ile Ile Ile Cys Leu Pro Thr Gly Ser Gly Lys Thr 
                325                 330                 335     


Arg Val Ala Val Tyr Ile Ala Lys Asp His Leu Asp Lys Lys Lys Lys 
            340                 345                 350         


Ala Ser Glu Pro Gly Lys Val Ile Val Leu Val Asn Lys Val Leu Leu 
        355                 360                 365             


Val Glu Gln Leu Phe Arg Lys Glu Phe Gln Pro Phe Leu Lys Lys Trp 
    370                 375                 380                 


Tyr Arg Val Ile Gly Leu Ser Gly Asp Thr Gln Leu Lys Ile Ser Phe 
385                 390                 395                 400 


Pro Glu Val Val Lys Ser Cys Asp Ile Ile Ile Ser Thr Ala Gln Ile 
                405                 410                 415     


Leu Glu Asn Ser Leu Leu Asn Leu Glu Asn Gly Glu Asp Ala Gly Val 
            420                 425                 430         


Gln Leu Ser Asp Phe Ser Leu Ile Ile Ile Asp Glu Cys His His Thr 
        435                 440                 445             


Asn Lys Glu Ala Val Tyr Asn Asn Ile Met Arg His Tyr Leu Met Gln 
    450                 455                 460                 


Lys Leu Lys Asn Asn Arg Leu Lys Lys Glu Asn Lys Pro Val Ile Pro 
465                 470                 475                 480 


Leu Pro Gln Ile Leu Gly Leu Thr Ala Ser Pro Gly Val Gly Gly Ala 
                485                 490                 495     


Thr Lys Gln Ala Lys Ala Glu Glu His Ile Leu Lys Leu Cys Ala Asn 
            500                 505                 510         


Leu Asp Ala Phe Thr Ile Lys Thr Val Lys Glu Asn Leu Asp Gln Leu 
        515                 520                 525             


Lys Asn Gln Ile Gln Glu Pro Cys Lys Lys Phe Ala Ile Ala Asp Ala 
    530                 535                 540                 


Thr Arg Glu Asp Pro Phe Lys Glu Lys Leu Leu Glu Ile Met Thr Arg 
545                 550                 555                 560 


Ile Gln Thr Tyr Cys Gln Met Ser Pro Met Ser Asp Phe Gly Thr Gln 
                565                 570                 575     


Pro Tyr Glu Gln Trp Ala Ile Gln Met Glu Lys Lys Ala Ala Lys Glu 
            580                 585                 590         


Gly Asn Arg Lys Glu Arg Val Cys Ala Glu His Leu Arg Lys Tyr Asn 
        595                 600                 605             


Glu Ala Leu Gln Ile Asn Asp Thr Ile Arg Met Ile Asp Ala Tyr Thr 
    610                 615                 620                 


His Leu Glu Thr Phe Tyr Asn Glu Glu Lys Asp Lys Lys Phe Ala Val 
625                 630                 635                 640 


Ile Glu Asp Asp Ser Asp Glu Gly Gly Asp Asp Glu Tyr Cys Asp Gly 
                645                 650                 655     


Asp Glu Asp Glu Asp Asp Leu Lys Lys Pro Leu Lys Leu Asp Glu Thr 
            660                 665                 670         


Asp Arg Phe Leu Met Thr Leu Phe Phe Glu Asn Asn Lys Met Leu Lys 
        675                 680                 685             


Arg Leu Ala Glu Asn Pro Glu Tyr Glu Asn Glu Lys Leu Thr Lys Leu 
    690                 695                 700                 


Arg Asn Thr Ile Met Glu Gln Tyr Thr Arg Thr Glu Glu Ser Ala Arg 
705                 710                 715                 720 


Gly Ile Ile Phe Thr Lys Thr Arg Gln Ser Ala Tyr Ala Leu Ser Gln 
                725                 730                 735     


Trp Ile Thr Glu Asn Glu Lys Phe Ala Glu Val Gly Val Lys Ala His 
            740                 745                 750         


His Leu Ile Gly Ala Gly His Ser Ser Glu Phe Lys Pro Met Thr Gln 
        755                 760                 765             


Asn Glu Gln Lys Glu Val Ile Ser Lys Phe Arg Thr Gly Lys Ile Asn 
    770                 775                 780                 


Leu Leu Ile Ala Thr Thr Val Ala Glu Glu Gly Leu Asp Ile Lys Glu 
785                 790                 795                 800 


Cys Asn Ile Val Ile Arg Tyr Gly Leu Val Thr Asn Glu Ile Ala Met 
                805                 810                 815     


Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Glu Ser Thr Tyr Val Leu 
            820                 825                 830         


Val Ala His Ser Gly Ser Gly Val Ile Glu His Glu Thr Val Asn Asp 
        835                 840                 845             


Phe Arg Glu Lys Met Met Tyr Lys Ala Ile His Cys Val Gln Asn Met 
    850                 855                 860                 


Lys Pro Glu Glu Tyr Ala His Lys Ile Leu Glu Leu Gln Met Gln Ser 
865                 870                 875                 880 


Ile Met Glu Lys Lys Met Lys Thr Lys Arg Asn Ile Ala Lys His Tyr 
                885                 890                 895     


Lys Asn Asn Pro Ser Leu Ile Thr Phe Leu Cys Lys Asn Cys Ser Val 
            900                 905                 910         


Leu Ala Cys Ser Gly Glu Asp Ile His Val Ile Glu Lys Met His His 
        915                 920                 925             


Val Asn Met Thr Pro Glu Phe Lys Glu Leu Tyr Ile Val Arg Glu Asn 
    930                 935                 940                 


Lys Ala Leu Gln Lys Lys Cys Ala Asp Tyr Gln Ile Asn Gly Glu Ile 
945                 950                 955                 960 


Ile Cys Lys Cys Gly Gln Ala Trp Gly Thr Met Met Val His Lys Gly 
                965                 970                 975     


Leu Asp Leu Pro Cys Leu Lys Ile Arg Asn Phe Val Val Val Phe Lys 
            980                 985                 990         


Asn Asn Ser Thr Lys Lys Gln Tyr  Lys Lys Trp Val Glu  Leu Pro Ile 
        995                 1000                 1005             


Thr Phe  Pro Asn Leu Asp Tyr  Ser Glu Cys Cys Leu  Phe Ser Asp 
    1010                 1015                 1020             


Glu Asp  
    1025 


<210>  47
<211>  4411
<212>  DNA
<213>  Homo sapiens

<400>  47
aactgaaaat ccacaagaca gaatagccag atctcagagg agcctggcta agcaaaaccc       60

tgcagaacgg ctgcctaatt tacagcaacc atgaggccac ttaaggatgc agcaagaagg      120

agccatctgc aatccaggaa gaaattcctt gccaggaacc aaattggttg tcaccttcat      180

ctaggacttc tagcctcgag aacttacaaa tggtgatgat catcaggtca aggatagtct      240

ggagcaattg agatgtcact ttacatggga gttatccatt gatgacgatg aaatgcctga      300

tttagaaaac agagtcttgg atcagattga attcctagac accaaataca gtgtgggaat      360

acacaaccta ctagcctatg tgaaacacct gaaaggccag aatgaggaag ccctgaagag      420

cttaaaagaa gctgaaaact taatgcagga agaacatgac aaccaagcaa atgtgaggag      480

tctggtgacc tggggcaact ttgcctggat gtattaccac atgggcagac tggcagaagc      540

ccagacttac ctggacaagg tggagaacat ttgcaagaag ctttcaaatc ccttccgcta      600

tagaatggag tgtccagaaa tagactgtga ggaaggatgg gccttgctga agtgtggagg      660

aaaaaattat gaacgggcca aggcctgctt tgaaaaggtg cttgaagtgg accctgaaaa      720

ccctgaatcc agcgctgggt atgcgatctc tgcctatcgc ctggatggct ttaaattagc      780

cacaaaaaat cacaagccat tttctttgct tcccctaagg caggctgtcc gcttaaatcc      840

agacaatgga tatattaagg ttctccttgc cctgaagctt caggatgaag gacaggaagc      900

tgaaggagaa aagtacattg aagaagctct agccaacatg tcctcacaga cctatgtctt      960

tcgatatgca gccaagtttt accgaagaaa aggctctgtg gataaagctc ttgagttatt     1020

aaaaaaggcc ttgcaggaaa cacccacttc tgtcttactg catcaccaga tagggctttg     1080

ctacaaggca caaatgatcc aaatcaagga ggctacaaaa gggcagccta gagggcagaa     1140

cagagaaaag ctagacaaaa tgataagatc agccatattt cattttgaat ctgcagtgga     1200

aaaaaagccc acatttgagg tggctcatct agacctggca agaatgtata tagaagcagg     1260

caatcacaga aaagctgaag agaattttca aaaattgtta tgcatgaaac cagtggtaga     1320

agaaacaatg caagacatac atttccacta tggtcggttt caggaatttc aaaagaaatc     1380

tgacgtcaat gcaattatcc attatttaaa agctataaaa atagaacagg catcattaac     1440

aagggataaa agtatcaatt ctttgaagaa attggtttta aggaaacttc ggagaaaggc     1500

attagatctg gaaagcttga gcctccttgg gttcgtctac aaattggaag gaaatatgaa     1560

tgaagccctg gagtactatg agcgggccct gagactggct gctgactttg agaactctgt     1620

gagacaaggt ccttaggcac ccagatatca gccactttca catttcattt cattttatgc     1680

taacatttac taatcatctt ttctgcttac tgttttcaga aacattataa ttcactgtaa     1740

tgatgtaatt cttgaataat aaatctgaca aaatattagt tgtgttcaac aattagtgaa     1800

acagaatgtg tgtatgcatg taagaaagag aaatcatttg tatgagtgct atgtagtaga     1860

gaaaaaatgt tagttaactt tgtaggaaat aaaacattgg acttacacta aatgtttaat     1920

tcattcattt tattgtgaaa taaaaataaa atccttagct cctccaccaa ctgaacagac     1980

cctcttggcc aaggagaccc cagaaacctt aaaaactaag tttcccaacc atgacaagat     2040

gagagatcat tcacacctca ttatattccc tcccttgcta actgccattg gactttttcc     2100

actgagttaa acagaaaccc atggaaaaca aagaacagaa gactcactcc ttggctgact     2160

tcacctagct cactccacgt agcgccacag ccagactccc ctcccctctt gcggtttcca     2220

catgacaact gatcagcctt ccctcctgat aagtgaccac tgcccacaga ctggttctgg     2280

ccagtccatg gaggctgcac acagggtgcc tctatgtcct ttgtttcacc ttttgatata     2340

gaaaggctaa ttttgctgta ttttaatgtt aagtctccac cacagagtga acacagaatg     2400

catgtgacat acatgtttac ataccactat tgtgtgactg cccctcatga atattcatag     2460

ccccccataa cctgttaact atgtgtgtct agccaatcca ccaaccataa aacttctgta     2520

ataccctccc ttcctccaag agcctgcttt tggttgctgt ggtaggctct gcttcccagg     2580

ctgcaggttg caggagagga ggctgcagtg gctcacgcct gtaatctcag cacttcgatg     2640

ggacgaggca ggcagatcac ctgaacccag gagttcgaga gcagccttgg caatggcaaa     2700

accaaccgtc tctacaaaaa atgcaaaaac ttagctgggt gtggtggcat gcacctgtag     2760

cttcagttcc agctactcag gaggctgagg tgagtggact gctggagcca gggagttcga     2820

ggctgcagtg tcgagatctt gccactgcac tccattctgg atgatagaac gagaccccat     2880

ctcaaaaaaa aaaaaagttc tctccaattg tatatagctt gtgattttat gtcaacacta     2940

tcaataaata gctttcagtg caagaaacca aaaatactgt aataaacagg cacatattct     3000

tcccaaacct catgcagttt acaatctagt gagagacaca gatagcagta cagagtcaat     3060

taaaggttag ttttcttcat gaagatgttt taattttaat tcaatgtgaa agggttccaa     3120

ggagtttatc ttgttttatg ccattttatt tgaagcacta cttactaagt catttgctga     3180

tattaatcta gttaaatcaa gaaatattac atgaaaatgt tgctaaatca gagatcatgg     3240

gtaacaatca cctttgatta tgaataatca tattttattg aaaggcaagg cacaacaaat     3300

aataagaagg aaaaaataaa taagcaatgt tattgatctt tcattctgta tatgttttgg     3360

ggggaatata ctagtttctt ttagtggctg taacaaatta ccacaaactt ggtgacttaa     3420

aatttcacag atttactctt tcttacagtt ctggaggtca gaagtctgaa atgggtttca     3480

atgagccaaa gtcaaggtat tgatgacgct acactcctcc ggaggctcta ggcagatagc     3540

cttttccagc ttccagaggc tgcctgaatt ctttcatcca tcttaaaaac caacagtgta     3600

gtagcctcaa atctctctct ctgcttcctt cttcacatct ccttctctcc tctgactctt     3660

ttgcctcttt cttctaagga cgcaccaggt ccacctgcat aatccagaat aattgcccca     3720

tccgcaaatc cttaatttaa taacatctgc aaagtccctt ttgctatgta aagtagcatg     3780

ttcacaggtt ctggagactt ggccatggat acgattgcgg ggggggcatt attcttacca     3840

cagagcaccc caagaaaatc tccaaatttt gggcttccaa tccattttgc ttcaattatt     3900

taatattttt actccttcca gtagatactg atttcatcca ttgcccttaa gaaggtagga     3960

cagagattat ggcacatctc acattaaatg ctatattttc gttggaaata cattttttgc     4020

ttcaactttt attttaaatt caagggtaca tgtgcaggat gttcaggttt gttacacagg     4080

taaacgtgtg ccatggcggt ttgctgaaca gatcatccca tcaccaacag atcatcccat     4140

tgagaggtga agccggctgg gcttctgggt tgggtgggga cttggagaac ttttctgtct     4200

agctaaagta ttgtaaaatg gaccagtcaa cactctgtaa aatggaccaa tcagctctct     4260

gtaaaatgga ccaatcagca ggatgtgggt ggggccaagt aagggaataa aagcaggcca     4320

cccgagctgg cagcggcaac ccgctcgggt ccccttccat gctgtggaag ttttgttctt     4380

tcgctctttc aataaatctt gctgctgctc a                                    4411


<210>  48
<211>  4302
<212>  DNA
<213>  Homo sapiens

<400>  48
aactgaaaat ccacaagaca gaatagccag atctcagagg agcctggcta agcaaaaccc       60

tgcagaacgg ctgcctaatt tacagcaacc atgagtacaa atggtgatga tcatcaggtc      120

aaggatagtc tggagcaatt gagatgtcac tttacatggg agttatccat tgatgacgat      180

gaaatgcctg atttagaaaa cagagtcttg gatcagattg aattcctaga caccaaatac      240

agtgtgggaa tacacaacct actagcctat gtgaaacacc tgaaaggcca gaatgaggaa      300

gccctgaaga gcttaaaaga agctgaaaac ttaatgcagg aagaacatga caaccaagca      360

aatgtgagga gtctggtgac ctggggcaac tttgcctgga tgtattacca catgggcaga      420

ctggcagaag cccagactta cctggacaag gtggagaaca tttgcaagaa gctttcaaat      480

cccttccgct atagaatgga gtgtccagaa atagactgtg aggaaggatg ggccttgctg      540

aagtgtggag gaaaaaatta tgaacgggcc aaggcctgct ttgaaaaggt gcttgaagtg      600

gaccctgaaa accctgaatc cagcgctggg tatgcgatct ctgcctatcg cctggatggc      660

tttaaattag ccacaaaaaa tcacaagcca ttttctttgc ttcccctaag gcaggctgtc      720

cgcttaaatc cagacaatgg atatattaag gttctccttg ccctgaagct tcaggatgaa      780

ggacaggaag ctgaaggaga aaagtacatt gaagaagctc tagccaacat gtcctcacag      840

acctatgtct ttcgatatgc agccaagttt taccgaagaa aaggctctgt ggataaagct      900

cttgagttat taaaaaaggc cttgcaggaa acacccactt ctgtcttact gcatcaccag      960

atagggcttt gctacaaggc acaaatgatc caaatcaagg aggctacaaa agggcagcct     1020

agagggcaga acagagaaaa gctagacaaa atgataagat cagccatatt tcattttgaa     1080

tctgcagtgg aaaaaaagcc cacatttgag gtggctcatc tagacctggc aagaatgtat     1140

atagaagcag gcaatcacag aaaagctgaa gagaattttc aaaaattgtt atgcatgaaa     1200

ccagtggtag aagaaacaat gcaagacata catttccact atggtcggtt tcaggaattt     1260

caaaagaaat ctgacgtcaa tgcaattatc cattatttaa aagctataaa aatagaacag     1320

gcatcattaa caagggataa aagtatcaat tctttgaaga aattggtttt aaggaaactt     1380

cggagaaagg cattagatct ggaaagcttg agcctccttg ggttcgtcta caaattggaa     1440

ggaaatatga atgaagccct ggagtactat gagcgggccc tgagactggc tgctgacttt     1500

gagaactctg tgagacaagg tccttaggca cccagatatc agccactttc acatttcatt     1560

tcattttatg ctaacattta ctaatcatct tttctgctta ctgttttcag aaacattata     1620

attcactgta atgatgtaat tcttgaataa taaatctgac aaaatattag ttgtgttcaa     1680

caattagtga aacagaatgt gtgtatgcat gtaagaaaga gaaatcattt gtatgagtgc     1740

tatgtagtag agaaaaaatg ttagttaact ttgtaggaaa taaaacattg gacttacact     1800

aaatgtttaa ttcattcatt ttattgtgaa ataaaaataa aatccttagc tcctccacca     1860

actgaacaga ccctcttggc caaggagacc ccagaaacct taaaaactaa gtttcccaac     1920

catgacaaga tgagagatca ttcacacctc attatattcc ctcccttgct aactgccatt     1980

ggactttttc cactgagtta aacagaaacc catggaaaac aaagaacaga agactcactc     2040

cttggctgac ttcacctagc tcactccacg tagcgccaca gccagactcc cctcccctct     2100

tgcggtttcc acatgacaac tgatcagcct tccctcctga taagtgacca ctgcccacag     2160

actggttctg gccagtccat ggaggctgca cacagggtgc ctctatgtcc tttgtttcac     2220

cttttgatat agaaaggcta attttgctgt attttaatgt taagtctcca ccacagagtg     2280

aacacagaat gcatgtgaca tacatgttta cataccacta ttgtgtgact gcccctcatg     2340

aatattcata gccccccata acctgttaac tatgtgtgtc tagccaatcc accaaccata     2400

aaacttctgt aataccctcc cttcctccaa gagcctgctt ttggttgctg tggtaggctc     2460

tgcttcccag gctgcaggtt gcaggagagg aggctgcagt ggctcacgcc tgtaatctca     2520

gcacttcgat gggacgaggc aggcagatca cctgaaccca ggagttcgag agcagccttg     2580

gcaatggcaa aaccaaccgt ctctacaaaa aatgcaaaaa cttagctggg tgtggtggca     2640

tgcacctgta gcttcagttc cagctactca ggaggctgag gtgagtggac tgctggagcc     2700

agggagttcg aggctgcagt gtcgagatct tgccactgca ctccattctg gatgatagaa     2760

cgagacccca tctcaaaaaa aaaaaaagtt ctctccaatt gtatatagct tgtgatttta     2820

tgtcaacact atcaataaat agctttcagt gcaagaaacc aaaaatactg taataaacag     2880

gcacatattc ttcccaaacc tcatgcagtt tacaatctag tgagagacac agatagcagt     2940

acagagtcaa ttaaaggtta gttttcttca tgaagatgtt ttaattttaa ttcaatgtga     3000

aagggttcca aggagtttat cttgttttat gccattttat ttgaagcact acttactaag     3060

tcatttgctg atattaatct agttaaatca agaaatatta catgaaaatg ttgctaaatc     3120

agagatcatg ggtaacaatc acctttgatt atgaataatc atattttatt gaaaggcaag     3180

gcacaacaaa taataagaag gaaaaaataa ataagcaatg ttattgatct ttcattctgt     3240

atatgttttg gggggaatat actagtttct tttagtggct gtaacaaatt accacaaact     3300

tggtgactta aaatttcaca gatttactct ttcttacagt tctggaggtc agaagtctga     3360

aatgggtttc aatgagccaa agtcaaggta ttgatgacgc tacactcctc cggaggctct     3420

aggcagatag ccttttccag cttccagagg ctgcctgaat tctttcatcc atcttaaaaa     3480

ccaacagtgt agtagcctca aatctctctc tctgcttcct tcttcacatc tccttctctc     3540

ctctgactct tttgcctctt tcttctaagg acgcaccagg tccacctgca taatccagaa     3600

taattgcccc atccgcaaat ccttaattta ataacatctg caaagtccct tttgctatgt     3660

aaagtagcat gttcacaggt tctggagact tggccatgga tacgattgcg gggggggcat     3720

tattcttacc acagagcacc ccaagaaaat ctccaaattt tgggcttcca atccattttg     3780

cttcaattat ttaatatttt tactccttcc agtagatact gatttcatcc attgccctta     3840

agaaggtagg acagagatta tggcacatct cacattaaat gctatatttt cgttggaaat     3900

acattttttg cttcaacttt tattttaaat tcaagggtac atgtgcagga tgttcaggtt     3960

tgttacacag gtaaacgtgt gccatggcgg tttgctgaac agatcatccc atcaccaaca     4020

gatcatccca ttgagaggtg aagccggctg ggcttctggg ttgggtgggg acttggagaa     4080

cttttctgtc tagctaaagt attgtaaaat ggaccagtca acactctgta aaatggacca     4140

atcagctctc tgtaaaatgg accaatcagc aggatgtggg tggggccaag taagggaata     4200

aaagcaggcc acccgagctg gcagcggcaa cccgctcggg tccccttcca tgctgtggaa     4260

gttttgttct ttcgctcttt caataaatct tgctgctgct ca                        4302


<210>  49
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Pro Asp Leu Glu Asn Arg Val Leu Asp Gln Ile Glu Phe Leu Asp 
1               5                   10                  15      


Thr Lys Tyr Ser Val Gly Ile His Asn Leu Leu Ala Tyr Val Lys His 
            20                  25                  30          


Leu Lys Gly Gln Asn Glu Glu Ala Leu Lys Ser Leu Lys Glu Ala Glu 
        35                  40                  45              


Asn Leu Met Gln Glu Glu His Asp Asn Gln Ala Asn Val Arg Ser Leu 
    50                  55                  60                  


Val Thr Trp Gly Asn Phe Ala Trp Met Tyr Tyr His Met Gly Arg Leu 
65                  70                  75                  80  


Ala Glu Ala Gln Thr Tyr Leu Asp Lys Val Glu Asn Ile Cys Lys Lys 
                85                  90                  95      


Leu Ser Asn Pro Phe Arg Tyr Arg Met Glu Cys Pro Glu Ile Asp Cys 
            100                 105                 110         


Glu Glu Gly Trp Ala Leu Leu Lys Cys Gly Gly Lys Asn Tyr Glu Arg 
        115                 120                 125             


Ala Lys Ala Cys Phe Glu Lys Val Leu Glu Val Asp Pro Glu Asn Pro 
    130                 135                 140                 


Glu Ser Ser Ala Gly Tyr Ala Ile Ser Ala Tyr Arg Leu Asp Gly Phe 
145                 150                 155                 160 


Lys Leu Ala Thr Lys Asn His Lys Pro Phe Ser Leu Leu Pro Leu Arg 
                165                 170                 175     


Gln Ala Val Arg Leu Asn Pro Asp Asn Gly Tyr Ile Lys Val Leu Leu 
            180                 185                 190         


Ala Leu Lys Leu Gln Asp Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr 
        195                 200                 205             


Ile Glu Glu Ala Leu Ala Asn Met Ser Ser Gln Thr Tyr Val Phe Arg 
    210                 215                 220                 


Tyr Ala Ala Lys Phe Tyr Arg Arg Lys Gly Ser Val Asp Lys Ala Leu 
225                 230                 235                 240 


Glu Leu Leu Lys Lys Ala Leu Gln Glu Thr Pro Thr Ser Val Leu Leu 
                245                 250                 255     


His His Gln Ile Gly Leu Cys Tyr Lys Ala Gln Met Ile Gln Ile Lys 
            260                 265                 270         


Glu Ala Thr Lys Gly Gln Pro Arg Gly Gln Asn Arg Glu Lys Leu Asp 
        275                 280                 285             


Lys Met Ile Arg Ser Ala Ile Phe His Phe Glu Ser Ala Val Glu Lys 
    290                 295                 300                 


Lys Pro Thr Phe Glu Val Ala His Leu Asp Leu Ala Arg Met Tyr Ile 
305                 310                 315                 320 


Glu Ala Gly Asn His Arg Lys Ala Glu Glu Asn Phe Gln Lys Leu Leu 
                325                 330                 335     


Cys Met Lys Pro Val Val Glu Glu Thr Met Gln Asp Ile His Phe His 
            340                 345                 350         


Tyr Gly Arg Phe Gln Glu Phe Gln Lys Lys Ser Asp Val Asn Ala Ile 
        355                 360                 365             


Ile His Tyr Leu Lys Ala Ile Lys Ile Glu Gln Ala Ser Leu Thr Arg 
    370                 375                 380                 


Asp Lys Ser Ile Asn Ser Leu Lys Lys Leu Val Leu Arg Lys Leu Arg 
385                 390                 395                 400 


Arg Lys Ala Leu Asp Leu Glu Ser Leu Ser Leu Leu Gly Phe Val Tyr 
                405                 410                 415     


Lys Leu Glu Gly Asn Met Asn Glu Ala Leu Glu Tyr Tyr Glu Arg Ala 
            420                 425                 430         


Leu Arg Leu Ala Ala Asp Phe Glu Asn Ser Val Arg Gln Gly Pro 
        435                 440                 445         


<210>  50
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Thr Asn Gly Asp Asp His Gln Val Lys Asp Ser Leu Glu Gln 
1               5                   10                  15      


Leu Arg Cys His Phe Thr Trp Glu Leu Ser Ile Asp Asp Asp Glu Met 
            20                  25                  30          


Pro Asp Leu Glu Asn Arg Val Leu Asp Gln Ile Glu Phe Leu Asp Thr 
        35                  40                  45              


Lys Tyr Ser Val Gly Ile His Asn Leu Leu Ala Tyr Val Lys His Leu 
    50                  55                  60                  


Lys Gly Gln Asn Glu Glu Ala Leu Lys Ser Leu Lys Glu Ala Glu Asn 
65                  70                  75                  80  


Leu Met Gln Glu Glu His Asp Asn Gln Ala Asn Val Arg Ser Leu Val 
                85                  90                  95      


Thr Trp Gly Asn Phe Ala Trp Met Tyr Tyr His Met Gly Arg Leu Ala 
            100                 105                 110         


Glu Ala Gln Thr Tyr Leu Asp Lys Val Glu Asn Ile Cys Lys Lys Leu 
        115                 120                 125             


Ser Asn Pro Phe Arg Tyr Arg Met Glu Cys Pro Glu Ile Asp Cys Glu 
    130                 135                 140                 


Glu Gly Trp Ala Leu Leu Lys Cys Gly Gly Lys Asn Tyr Glu Arg Ala 
145                 150                 155                 160 


Lys Ala Cys Phe Glu Lys Val Leu Glu Val Asp Pro Glu Asn Pro Glu 
                165                 170                 175     


Ser Ser Ala Gly Tyr Ala Ile Ser Ala Tyr Arg Leu Asp Gly Phe Lys 
            180                 185                 190         


Leu Ala Thr Lys Asn His Lys Pro Phe Ser Leu Leu Pro Leu Arg Gln 
        195                 200                 205             


Ala Val Arg Leu Asn Pro Asp Asn Gly Tyr Ile Lys Val Leu Leu Ala 
    210                 215                 220                 


Leu Lys Leu Gln Asp Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Glu Glu Ala Leu Ala Asn Met Ser Ser Gln Thr Tyr Val Phe Arg Tyr 
                245                 250                 255     


Ala Ala Lys Phe Tyr Arg Arg Lys Gly Ser Val Asp Lys Ala Leu Glu 
            260                 265                 270         


Leu Leu Lys Lys Ala Leu Gln Glu Thr Pro Thr Ser Val Leu Leu His 
        275                 280                 285             


His Gln Ile Gly Leu Cys Tyr Lys Ala Gln Met Ile Gln Ile Lys Glu 
    290                 295                 300                 


Ala Thr Lys Gly Gln Pro Arg Gly Gln Asn Arg Glu Lys Leu Asp Lys 
305                 310                 315                 320 


Met Ile Arg Ser Ala Ile Phe His Phe Glu Ser Ala Val Glu Lys Lys 
                325                 330                 335     


Pro Thr Phe Glu Val Ala His Leu Asp Leu Ala Arg Met Tyr Ile Glu 
            340                 345                 350         


Ala Gly Asn His Arg Lys Ala Glu Glu Asn Phe Gln Lys Leu Leu Cys 
        355                 360                 365             


Met Lys Pro Val Val Glu Glu Thr Met Gln Asp Ile His Phe His Tyr 
    370                 375                 380                 


Gly Arg Phe Gln Glu Phe Gln Lys Lys Ser Asp Val Asn Ala Ile Ile 
385                 390                 395                 400 


His Tyr Leu Lys Ala Ile Lys Ile Glu Gln Ala Ser Leu Thr Arg Asp 
                405                 410                 415     


Lys Ser Ile Asn Ser Leu Lys Lys Leu Val Leu Arg Lys Leu Arg Arg 
            420                 425                 430         


Lys Ala Leu Asp Leu Glu Ser Leu Ser Leu Leu Gly Phe Val Tyr Lys 
        435                 440                 445             


Leu Glu Gly Asn Met Asn Glu Ala Leu Glu Tyr Tyr Glu Arg Ala Leu 
    450                 455                 460                 


Arg Leu Ala Ala Asp Phe Glu Asn Ser Val Arg Gln Gly Pro 
465                 470                 475             


<210>  51
<211>  2407
<212>  DNA
<213>  Homo sapiens

<400>  51
gtggaaacct cttcagcatt tgcttggaat cagtaagcta aaaacaaaat caaccgggac       60

cccagctttt cagaactgca gggaaacagc catcatgagt gaggtcacca agaattccct      120

ggagaaaatc cttccacagc tgaaatgcca tttcacctgg aacttattca aggaagacag      180

tgtctcaagg gatctagaag atagagtgtg taaccagatt gaatttttaa acactgagtt      240

caaagctaca atgtacaact tgttggccta cataaaacac ctagatggta acaacgaggc      300

agccctggaa tgcttacggc aagctgaaga gttaatccag caagaacatg ctgaccaagc      360

agaaatcaga agtctagtca cttggggaaa ctacgcctgg gtctactatc acttgggcag      420

actctcagat gctcagattt atgtagataa ggtgaaacaa acctgcaaga aattttcaaa      480

tccatacagt attgagtatt ctgaacttga ctgtgaggaa gggtggacac aactgaagtg      540

tggaagaaat gaaagggcga aggtgtgttt tgagaaggct ctggaagaaa agcccaacaa      600

cccagaattc tcctctggac tggcaattgc gatgtaccat ctggataatc acccagagaa      660

acagttctct actgatgttt tgaagcaggc cattgagctg agtcctgata accaatacgt      720

caaggttctc ttgggcctga aactgcagaa gatgaataaa gaagctgaag gagagcagtt      780

tgttgaagaa gccttggaaa agtctccttg ccaaacagat gtcctccgca gtgcagccaa      840

attttacaga agaaaaggtg acctagacaa agctattgaa ctgtttcaac gggtgttgga      900

atccacacca aacaatggct acctctatca ccagattggg tgctgctaca aggcaaaagt      960

aagacaaatg cagaatacag gagaatctga agctagtgga aataaagaga tgattgaagc     1020

actaaagcaa tatgctatgg actattcgaa taaagctctt gagaagggac tgaatcctct     1080

gaatgcatac tccgatctcg ctgagttcct ggagacggaa tgttatcaga caccattcaa     1140

taaggaagtc cctgatgctg aaaagcaaca atcccatcag cgctactgca accttcagaa     1200

atataatggg aagtctgaag acactgctgt gcaacatggt ttagagggtt tgtccataag     1260

caaaaaatca actgacaagg aagagatcaa agaccaacca cagaatgtat ctgaaaatct     1320

gcttccacaa aatgcaccaa attattggta tcttcaagga ttaattcata agcagaatgg     1380

agatctgctg caagcagcca aatgttatga gaaggaactg ggccgcctgc taagggatgc     1440

cccttcaggc ataggcagta ttttcctgtc agcatctgag cttgaggatg gtagtgagga     1500

aatgggccag ggcgcagtca gctccagtcc cagagagctc ctctctaact cagagcaact     1560

gaactgagac agaggaggaa aacagagcat cagaagcctg cagtggtggt tgtgacgggt     1620

aggacgatag gaagacaggg ggccccaacc tgggattgct gagcagggaa gctttgcatg     1680

ttgctctaag gtacattttt aaagagttgt tttttggccg ggcgcagtgg ctcatgcctg     1740

taatcccagc actttgggag gccgaggtgg gcggatcacg aggtctggag tttgagacca     1800

tcctggctaa cacagtgaaa tcccgtctct actaaaaata caaaaaatta gccaggcgtg     1860

gtggctggca cctgtagtcc cagctacttg ggaggctgag gcaggagaat ggcgtgaacc     1920

tggaaggaag aggttgcagt gagccaagat tgcgcccctg cactccagcc tgggcaacag     1980

agcaagactc catctcaaaa aaaaaaaaaa aaaaaaaaaa gagttgtttt ctcatgttca     2040

ttatagttca ttacagttac atagtccgaa ggtcttacaa ctaatcactg gtagcaataa     2100

atgcttcagg cccacatgat gctgattagt tctcagtttt cattcagttc acaatataac     2160

caccattcct gccctccctg ccaagggtca taaatggtga ctgcctaaca acaaaatttg     2220

cagtctcatc tcattttcat ccagacttct ggaactcaaa gattaacttt tgactaaccc     2280

tggaatatct cttatctcac ttatagcttc aggcatgtat ttatatgtat tcttgatagc     2340

aataccataa tcaatgtgta ttcctgatag taatgctaca ataaatccaa acatttcaac     2400

tctgtta                                                               2407


<210>  52
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210>  53
<211>  12379
<212>  DNA
<213>  Homo sapiens

<400>  53
gacccgagag ccgctgagcc gcgaggccgg gccggggcgc cggccgggaa tgccgggggc       60

gcggcgccga cgccgaggcg cggccatgga ggggaagccc cgcgccgggg tcgcgctggc      120

cccggggccg agcggccgac ggccttccgc ccgctgcgcc cgccgccgcc gcccggggct      180

gctgcttcct ggcctctggc tgctgctgct ggcccggccg gcctcgtgcg ccccagatga      240

gctctctccg gaacagcaca acctttcttt atactccatg gagctcgtgc tgaagaaaag      300

cactgggcac agcgctgcac aagtggcctt aacagaaact gctcccggct cccagcacag      360

cagtcctctc catgtcacag ccccgccgtc tgccactact tttgatacag ccttttttaa      420

ccaaggaaaa cagaccaaaa gtacagcaga tcccagcatc tttgtggcaa cttacgtgtc      480

agtgacgagt aaagaggtgg ccgtcaatga cgatgagatg gataactttc tgccagatac      540

tcactggacc actccacgga tggtttctcc aatacagtat atcacagtca gcccaccagg      600

gctgcccagg gaagcattag aacctatgct cactccatca ttacccatgg tttctttaca      660

agatgaagaa gtgacatcgg gctggcagaa cacaacgcga caaccagcgg catatgctga      720

gtccgccagt catttccaca cctttcggtc agcttttcgc acctctgagg gcatcgttcc      780

aactcctggc aggaatttgg tgctttatcc tactgatgct tacagtcatt tatcaagcag      840

gactctgcca gagattgtgg cttccctaac agagggtgtg gaaaccaccc tttttttaag      900

ctcccggtct ttaatgccac agccgttagg cgacggcatt actataccgt tgccctcctt      960

gggggaggtc tcacagcctc cagaggaggt ttgggccaca agtgcagaca gatacactga     1020

tgtgaccact gtgttgagtc aaagcctaga agaaaccatc tctccaagaa cataccccac     1080

tgtgactgca tcgcacgcag cccttgcatt cagcaggaca cattctccat tgctttcaac     1140

tcctcttgca tttgcgtcct ctgcttcacc aactgatgtt tcatctaacc cctttctccc     1200

tagcgactcc agcaaaacat ccgaattgca tagcaattca gccctccccg gtcctgtgga     1260

caacactcat atcctgagcc cggtgtcctc attcagacca tacacttggt gtgcggcctg     1320

cactgtgcct tcacctcagc aagttctggc cacgagcctc atggagaaag acgtgggatc     1380

aggggatggt gccgagactc tgtgcatgac cgtgctggaa gaaagcagca tctctctaat     1440

gagtagcgtc gtagcagact tctctgaatt tgaggaagat cctcaagtat ttaatacgct     1500

tttcccctcc agacctatcg tcccactttc ttctagatcc atggaaatct cagagacgag     1560

tgttggcatt tctgccgagg tggatatgag tagtgttaca accacacagg ttccccctgc     1620

ccacggccgc ctctctgtgc cggcgtcact tgatcctact gctggctcct tgtctgttgc     1680

tgaaacccaa gtgacgccat ccagcgtgac cactgcattt ttctcggtca tcaccagcat     1740

tctccttgac tcatctttct ctgtcatagc aaacaaaaac acaccgtcgc ttgccgtcag     1800

agacccgagt gtttttacgc cttatagtct ggttccttca gtggagtctt cacttttctc     1860

tgaccaagaa cgttccagtt tttctgagca taaacccaga ggtgctttgg attttgcatc     1920

cagctttttc tcaacacccc cgctggaact cagcggctcc atctcttcgc cttcggaagc     1980

acctgcgtct ctgtctctga tgccgagtga cttgtccccc ttcacatctc agtctttttc     2040

tcccttggtt gagacattta cattgtttga ctctagtgat ctgcagtcat ctcagctgtc     2100

tcttcccagt tccacaaatc ttgagttttc gcagctccag ccaagttccg agctgccttt     2160

aaacaccatc atgttgctac ctagccgttc tgaggtgtca ccatggtcaa gcttcccttc     2220

tgattctctc gagtttgttg aagcgtctac ggtttcactg acggattcag aagctcattt     2280

tacctcagct ttcattgaaa ctacctccta tcttgagtct tcactcattt cccatgaatc     2340

cgcagtcact gcactggtgc cccccggctc tgagtctttt gacattttga ctgccgggat     2400

tcaagcaaca tcaccattga ccactgtcca cacaacgccc attttaactg agtcttcttt     2460

gttctcaact ctgacacctc ctgacgacca aatcagtgct ctagacggtc acgtgtctgt     2520

cctggcctct ttctccaaag ccattcccac tggtacggtg ttgatcactg acgcgtacct     2580

gccatcagga tcctcgtttg tttctgaagc aacccccttc cctctgccca cagagctgac     2640

cgtcgtgggc ccatcactca cacccacaga ggtgccactg aacacctcca cggaagtgag     2700

cacaaccagc accggtgctg ccactggtgg tcccctcgac tccaccctga tgggtgacgc     2760

cgcaagtcag agccccccag agagtagtgc tgctcctccc ctgccatccc tgcgtcccgt     2820

gactgccttc actctcgaag caacagtcga cacaccaaca ctggctactg ccaagccgcc     2880

atatgtttgt gatatcacag tccccgatgc ctatctgatc acaactgtgc tggccagaag     2940

agctgtgcag gagtacatca ttacagcaat caaagaagta ctgaggattc acttcaaccg     3000

tgcagtggaa ctgaaggttt acgaactatt tactgacttc acttttctgg taacatccgg     3060

tcctttcgtt tacacggcaa tatccgtcat aaatgtgctt ataaacagta agcttgtccg     3120

tgaccagact cctttaatcc tgtctgtgaa accttctttc cttgtgccag agtccaggtt     3180

ccaagttcaa acagtacttc agtttgtgcc tccgagtgtg gatactggct tctgcaactt     3240

cacccagcgc attgagaaag gcctaatgac agctctcttt gaagtgagaa aacaccacca     3300

gggaacgtat aacctcacgg tgcagatctt gaatatcacc atcagttcct caagggtgac     3360

tcctcggcgg ggcccggtga atatcatctt tgcggttaaa agcacacagg gatttttgaa     3420

tgggtcggaa gtgagcgagc tgctcagaaa cttgagtgtg gtggagttca gtttctatct     3480

gggataccca gtgctgcaga tcgcagagcc cttccagtat ccacagctca acttatctca     3540

gttgctgaag tcctcttggg tcagaacagt tctcctgggc gtcatggaga agcaactcca     3600

gaatgaagtg tttcaagccg agatggaacg caagctggcc cagctgctca gcgaggtttc     3660

caccagaagg cggatgtgga gaagggccac tgtagctgca gggaacagtg tggtgcaggt     3720

ggtaaatgtg tcgaggctgg agggagatga caatccggta cagctcatct actttgtgga     3780

ggatcaagat ggagaaagac tcagtgcagt caagtcttcg gacctgatta acaaaatgga     3840

cctccagaga gcagccatca tcttgggtta ccgaattcaa ggtgtcattg cccagcctgt     3900

cgacagggtg aagaggccgt ctccggaatc ccagagcaac aacttgtggg tcattgttgg     3960

cgtggtcatc ccagtgctgg tggtgatggt gattgttgtc atcctctact ggaaactatg     4020

ccgcacagac aagctagact ttcagcctga cactgtggcc aacattcagc agcgtcagaa     4080

gctgcagatc cctagtgtga agggcttcga ttttgctaag cagcatctgg gtcagcacaa     4140

taaagacgac atattgatta ttcatgagcc agcgccactg ccaggacctc tgaaggacca     4200

caccacgccc tcggaaaatg gagacgtgcc aagccccaag tcaaagatcc cttccaagaa     4260

tgttcgtcac agaggaagag tttctccctc agatgctgac tctacggtca gtgaagagtc     4320

cagcgagagg gacgcaggag ataagacgcc gggagccgtc aacgatggca ggtcccacag     4380

agctccgcag agcgggccac cactgcccag ttcgggaaat gagcagcact catcagcctc     4440

catcttcgag cacgtggaca ggatctcccg ccccccggag gctagccggc gggtccccag     4500

taagatccag cttatcgcca tgcagccgat cccggcacct cccgtccagc gcccctcccc     4560

agccgaccga gtggcggaaa gcaataaaat caacaaagag attcagaccg cgctgcggca     4620

caagtctgag atcgagcacc atcgcaacaa gatccgcctg cgcgccaagc gccgcgggca     4680

ctacgagttc ccggtggtag acgacctgtc ctcgggcgac actaaggagc gacaccgggt     4740

gtaccgcagg gcacagatgc agatcgacaa gatcctggac cccacggcca gcgtgccctc     4800

cgtgttcata gagcccagga agagctcacg gataaaacgt tctcccaagc ctcgccggaa     4860

acaccaggtc aacggctgtc ctgccgacgc tgagaaggac cggctcatca ccacagacag     4920

cgatggcacc tacaggaggc cccccggcgt ccacaactca gcctacatcg gatgcccatc     4980

ggatcctgac ctcccagccg atgtgcagac accatcctcg gtggaactgg ggaggtatcc     5040

agcccttccc ttcccggcct cccagtacat cccaccccag ccgtccatcg aggaggcacg     5100

ccagaccatg cactccctcc tggacgacgc ctttgccctc gtggccccca gcagccagcc     5160

tgccagcacc gcaggtgtag gccccggagt cccacccggc ctgcccgcaa acagcacccc     5220

ttcccaggaa gagaggcgag ccacccagtg ggggtccttc tacagcccag cccagacggc     5280

caacaatccc tgcagtagat acgaagacta tggaatgact cccccgacgg gtccattgcc     5340

aagaccaggt tttggccccg gtttgctgca gtctacagag ctggtgcccc ctgaccctca     5400

gcagccacag gcctccgccg aagccccatt tgctgccaga gggatctact cggaggagat     5460

gccgtcggtg gcccggcctc ggcctgtcgg gggtaccaca ggctcccaga tccagcacct     5520

gacacaggtg gggattgcca gcagaattgg agctcagcca gtggaaatcc cgccaagcag     5580

aggcagccag tatggggggc caggctggcc ttcgtacggg gaggacgaag cggggcgaag     5640

agaggccgtg ccaaggactt caggcaggga gccctcagct ccttccggga acctccccca     5700

ccggggactg cagggccctg ggctgggtta ccccaccagc tccacggaag acctccagcc     5760

tggccactcc tcggcctctc tcatcaaagc aatccgcgag gagctcctcc ggctctccca     5820

gaaacagagc accgtgcaga acttccacag ctgatcggcc tcgcctcgca gatttgccaa     5880

gtatccgctt cctgtggaag caagaccaaa aggaaatcaa ctgagtgggt gtttggaaga     5940

ggaaggagca actctcgggc agcctgccca agggagggag caagttgcaa tttagaagat     6000

gccatacgtc gtgtgacagc tcatgagcct ttcactgggc tggcaattgt ctgaacactt     6060

gggttcagtt gaaatatatg tattttggcc aaaagccagc agcacttcac aaaaacaaaa     6120

cacaaaccta agctaacaaa atgactgcat tcgtctcttt tttaaaggta gagattaaac     6180

tgtatagaca gcatagggat gaaaggaacc aagcgtttct gtgggattga gactggtacg     6240

tgtacgatga acctgctgct ttgttttctg agaagaggtt tgaagacatt ttattaacag     6300

cttaattttt ctcttttact ccataggaac ttattttaat agtaacatta acaacaagaa     6360

tactaagact gtttgggaat tttaaaaagc tactagtgag aaaccaaatg ataggttgta     6420

gagcctgatg actccaaaca aagccatcac ccgcattctt cctccttctt ctggtgctac     6480

agctccaagg gcccttcacc ttcatgtctg aaatggaact ttggcttttt cagtggaaga     6540

atatgttgaa ggtttcattt tgttctagaa aaaaaaaatc cctcccaaag tggggcaaaa     6600

agctttatat ttatttgatt atccaaaata cagatcaaag tttagatcta cattcttcat     6660

tgtatttgct gtttcttaat tgggcacaca caactcctgg tcatgtccca gttcagcacc     6720

gatcgctaag gccgatcctg tagaatgcgg ctttcaagag gtcctaactg atcctttctt     6780

ccactttgct gttgatttgt tcacaaatta tgtctgaatg agaaatcttc tgtaagcaga     6840

agttatttaa taattcccag caccacgaaa ttgttataca tacatcccta ccagtcacat     6900

tccctgtgtt cagagcctgg aaatgaaatt gagttcagtt cagcctctct gtaatgaatc     6960

aagaaatgta aaagagcttt gagaccccaa gggaaaggag agagttgctt ctcatttctg     7020

attttattgt gctgttactc tgtcgagtgg ctattaaaat tgtcttatgc tctttgggct     7080

aagaggggat catctcgctt aagatgtact cctgatgtaa acatttcccc cactttccaa     7140

ataatggtaa agaaaacagt ggcaagggct gttctgtttt ctggtacctg agtgaaactc     7200

agaagaaaag caggcttagc taagagattt tcactattaa cctgttttta ttagatcagc     7260

gaagacagtc atgcatcgct taatgatggg gatgcattct gagaaatgtg tcattaggct     7320

gttttgttgc tgtgccaaca tcctagattg tacttacaca acctacatgg tatagcctac     7380

tacacacctg ggctgtgtgg catggcctat tcctcttagg ctacaaacct gtacagcatg     7440

ttactgtact gaacacaatg gtaagtattt gtgtatctaa acatagctaa acatagaaaa     7500

ggtatggtaa aaatacaatt ttataatctt atgggactac catcaatatg tagaccgtca     7560

ttgaccaaaa catcctgatg tgtgcatgac tgtacttttc attaaataac agataagggg     7620

ctatagaatt tggggctctg actgatcaaa acctgtgtat ctgtgtcaag ttttaagacc     7680

cctgaaacag ctaaaacagg tttccaaagt gtaatcactg gatttcaaaa ccatgtttta     7740

gcccttcatt aatgaagcct gttgtacaga tttagagtct tacaatatga gggaagttgg     7800

ttctgggaag gtaagatgta gccagttttc atctgggcac ctctgaaaga gaaggagtgc     7860

aggagagtaa gtctctcaag gacgttcaac aaaggaccag cagcatctta tcaggcgatc     7920

ctcagaggct ccaaggagca ttggagagaa tgcccctttc tgggcttgat gtcttggttt     7980

tggtttaata ccaaatttct cttggtcttg gtttaatacc cgactcctcc caaattgaac     8040

gattatcttt gtatgtcact caaaaatacc aggtttcctg aatatgttat taagaatttc     8100

agatatccaa gcagaatttt attatggaca ccttgtaatg aattcaaatc gtgtgacagc     8160

aaacgggata aatggcccct tctcacccag ttccgctcag ggccatacag gcttgcacat     8220

agagtgtgct aaaaatggta acctcctttg agcattgcag aaagagggtt ctgtttcaaa     8280

ttgggctgac cgtaaaagca attttgatgt ctttcaaact accataaagg gattttaact     8340

gtatttttat tcttagaaac aatacacctt taaacagatg tcaagaccaa agatgatgta     8400

taataaacag ccggtggtta tggtgtggtg tgagcaggcc cccggatcac cagccctctg     8460

ctggtggtca taaagcacac acagtttgta cttgcttcct ctcgacgcct gccacaacag     8520

ttttgccagt caccaaactc agaaaaaact agctgtgtga gcagcaccgt accctagcgg     8580

tcttcagaca ttaagttcac gtcatccact gaaaggaagg gtccttgcgt tgacagcgtg     8640

tggctttgga gtccgtttat ggaagcactc tacaatgaac agttgaattt tatgtctatt     8700

cttttttcct attttaaaag ttctagtggt aacacaaact gtaaatttga gtcagaatgt     8760

ttggagaaat gttgtttttt tttttttcag agactacttt gtcactcact gaccatgtct     8820

ggttccttct ctgaacttca ttctccccat aagccaaaca agaacagacc tcccccgcca     8880

cctcccaggc accgtagttg tgagaatcag atgtgatcat gtgtgcagat gtcctgtgag     8940

gagggagcat aaagcactgt gaaaatgtag catgctgtct atgtggacgc cctaggatga     9000

gtgatgtgaa acgctgcact actgcggtga atgggttcac acatgggtaa tgagcaaaac     9060

cgaaagctcg gtgtgactca gtttcctcac tcccattttg ctttaatttc acttccttca     9120

ccaattttcc gattgcattt attaagcatc tttctgctcc cgactttctg gtgtctctgg     9180

caccaaataa cccagcagac atgagccttg ccttctgaga ttttagaatc taagatagca     9240

cgagtgggta tagaagatgg aagataccga taaataacat ggtttaagtg tcaataaaat     9300

tcattcgaag agatcaggcg cggtggctca cgcctgtaat cccagcattt tgggaggctg     9360

aggcaggtgg atcacttgag atcaagagct taaaaccagc ccaggcaaca tggcaaaacc     9420

ccgtctctac aaaaaaatac aaaaactagc tgggtgtggt ggcgcatgcc tgtagtccca     9480

gctgaggcac gataattgct tgaacccggg gggtggaggt tgcagtgagc tgagattgca     9540

ccactgtact ccaacctggg cgacagagca agactgtgtc tcaaaaagaa aaaaatttgt     9600

tcaaaagaca taaatgaatt aggcacccag aagaagttgc atgtttggaa atgcaatatc     9660

ttggggagac gtcaacttct gaagtgactt tgaaggcagg gcagctaccc aggcaaatgg     9720

cgtggaagga agagctgaga gtgggcctgg gaaaggctgt agggaaggag tgaagctgtc     9780

actgaaatga acttgatctt gatctgcttt gatatgggga cagaatcccc gactgcacta     9840

ttgagggagt ttcagaagag aaggaagagg tgctggaagg atgcttttgc agtcatgcag     9900

caaggaaacg accagggctg tgaagatcta cagaggaagt actccagtgt gggggaggca     9960

agggaagagg acgaaaatga tgagaatgac actgaggtca ttgtttagag cagatctcaa    10020

gcagccgttt ggccacgcca tatcctttgt ggagcatagt gggttatcta tctgtctgtc    10080

tgtctatgta tctgtctatc tatctatata tatattcagc ttctttactg ctacctacac    10140

atttttctcc aaattttatt aatttcatag tgttttgatt tgggtggcag atgactttta    10200

agcagtgggt gtttgccggc cagatctttc ctggcatgcg gactgtgagg caaagcacgg    10260

gtgaaggtag gcgctaaagg ctttgggcta aagccagcac gcggttctgt gctataggag    10320

tctcccgttt cccgtggaca ggttcagcgt tccttctttc gcacaacttt tttctaagtg    10380

ttccagtgac caagccagtc attcggacac tgatttgcag tgcattggca gtaattcaca    10440

aattagttgt tatataagtc tctctcatcc ctttcacact agattctcag acatgaatga    10500

atttgtcgtt tggaaggaaa gctgggtaac gttttgggca caggggaagg aggactccgg    10560

tcttaactcc cacgctaact ttagctcaag tggagttttc accgtggtca tttctacctc    10620

cggagcaagg tgccagcgcc agtactagag cctgcttatc cacatttgcc ctggacagga    10680

gcaggaggaa gtccacttct gtaccggcag acagagcatg tgaacacaaa acacatttct    10740

atggcatagt caactgaact tcatttttac atttaatcta acatgttaac acgttctaac    10800

agggtttcta tgagcagctg ctgtaacata ctcatcaact atgatagact taacacttgt    10860

tacctaatga acaaggagga tgtgcatttc gggtttcttt tgatattcgt ggaggtgatt    10920

gtcagtgttt aaacaggact actttctcca ctatgaagat gacttggaaa tcgcaacatc    10980

atggtacatt gctaagtcca tgcttgtgtg tgtgacagta ggcttgataa tttatcttaa    11040

aacacagcag cattgaaatt taggaaaaga atattaaatg cctttggaaa catgaaacaa    11100

agttaggagc cagtaagaaa gtgacagaag caatgaatgt cttaatgcag tatagttaaa    11160

atggcttccc acagggtaga taattatcca ggatccttcc ttttccttct tcctccaggt    11220

ttttcagggg tcacttcaca tttctaaaga aagagtgaat aggctgggca tggtggctca    11280

agcctctaat ctcaacgctt tgggaggctg aggcaggagg atcgcttgag gccaggagtt    11340

tgagaccacc ttgggcaaca taacgagacc ccgtctctac aaaaaaaatt taaaaattag    11400

ctgagcatgg tggcatgtgc cagtagtccc agctactcga aaggctaaga ctggaggatc    11460

gcttgagcca atgagttgga ggctgcagtg agctataatc acgccactgc actccagcct    11520

gggctgcagg gtgaggtcct gtctctggaa aaaaaaaaaa aaaaaaaagg aataggtaaa    11580

agggacagag gtgaaatttt gagtgacttg agtctcttgc agtccctgat tacacagaac    11640

ctttctgggc tacttggagc atcacgaata gtctttcctg tacttaccag atttcaagta    11700

ttcataactt gactccctaa gtgtacaagt tgggaatagt acagggccaa gttcaagtcg    11760

catatgctgt actgttcctc ctgcaaatgt ggggaaagaa gagggagata ctagaggaac    11820

tgaggctcca cccattcatt cagttgctct aagcaccaga ggacttgttt cagaaaaggg    11880

gagtgggaac gccctcgact ttgccctcct ccggagcatc tctgggacgc agggagtctg    11940

gctagcgtta ataggaaagg ttgctcggca gagctgccct ggagtactga cttgtctctc    12000

cctcctttgt caaggtccat gtttttctgg ctcttcctgc acactcatcc ctagattatg    12060

agcgttaatg tacgaaatgt gcagagcaaa ttgaggccaa ctgtggcatc aatactgcaa    12120

cttaaacttg acaatcatgg tttgctggtc ctcaaacagg cactgaaatc tcagtatggg    12180

tatacgattt aataatcggc ccctcccttc tatttgtcgg ttttatgttt ctatccttca    12240

atagctgcac tgttttctaa tgtgctgtag agtttttgaa ataatttatg caagtatttg    12300

gtttccatgt ttacaattta tacagctttc ctagcatttt aaatggaaat gtcaataaat    12360

gctatgaatt ggtgtcaaa                                                 12379


<210>  54
<211>  12498
<212>  DNA
<213>  Homo sapiens

<400>  54
ctctccggcc tccctccgcg ccggtgcgcg gcgccccgtc ccagccgcag ccgcagcggc       60

cgcccctccc ggacccgaga gccgctgagc cgcgaggccg ggccggggcg ccggccggga      120

atgccggggg cgcggcgccg acgccgaggc gcggccatgg aggggaagcc ccgcgccggg      180

gtcgcgctgg ccccggggcc gagcggccga cggccttccg cccgctgcgc ccgccgccgc      240

cgcccggggc tgctgcttcc tggcctctgg ctgctgctgc tggcccggcc ggcctcgtgc      300

gccccagatg agctctctcc ggaacagcac aacctttctt tatactccat ggagctcgtg      360

ctgaagaaaa gcactgggca cagcgctgca caagtggcct taacagaaac tgctcccggc      420

tcccagcaca gcagtcctct ccatgtcaca gccccgccgt ctgccactac ttttgataca      480

gcctttttta accaaggaaa acagaccaaa agtacagcag atcccagcat ctttgtggca      540

acttacgtgt cagtgacgag taaagaggtg gccgtcaatg acgatgagat ggataacttt      600

ctgccagata ctcactggac cactccacgg atggtttctc caatacagta tatcacagtc      660

agcccaccag ggctgcccag ggaagcatta gaacctatgc tcactccatc attacccatg      720

gtttctttac aagatgaaga agtgacatcg ggctggcaga acacaacgcg acaaccagcg      780

gcatatgctg agtccgccag tcatttccac acctttcggt cagcttttcg cacctctgag      840

ggcatcgttc caactcctgg caggaatttg gtgctttatc ctactgatgc ttacagtcat      900

ttatcaagca ggactctgcc agagattgtg gcttccctaa cagagggtgt ggaaaccacc      960

ctttttttaa gctcccggtc tttaatgcca cagccgttag gcgacggcat tactataccg     1020

ttgccctcct tgggggaggt ctcacagcct ccagaggagg tttgggccac aagtgcagac     1080

agatacactg atgtgaccac tgtgttgagt caaagcctag aagaaaccat ctctccaaga     1140

acatacccca ctgtgactgc atcgcacgca gcccttgcat tcagcaggac acattctcca     1200

ttgctttcaa ctcctcttgc atttgcgtcc tctgcttcac caactgatgt ttcatctaac     1260

ccctttctcc ctagcgactc cagcaaaaca tccgaattgc atagcaattc agccctcccc     1320

ggtcctgtgg acaacactca tatcctgagc ccggtgtcct cattcagacc atacacttgg     1380

tgtgcggcct gcactgtgcc ttcacctcag caagttctgg ccacgagcct catggagaaa     1440

gacgtgggat caggggatgg tgccgagact ctgtgcatga ccgtgctgga agaaagcagc     1500

atctctctaa tgagtagcgt cgtagcagac ttctctgaat ttgaggaaga tcctcaagta     1560

tttaatacgc ttttcccctc cagacctatc gtcccacttt cttctagatc catggaaatc     1620

tcagagacga gtgttggcat ttctgccgag gtggatatga gtagtgttac aaccacacag     1680

gttccccctg cccacggccg cctctctgtg ccggcgtcac ttgatcctac tgctggctcc     1740

ttgtctgttg ctgaaaccca agtgacgcca tccagcgtga ccactgcatt tttctcggtc     1800

atcaccagca ttctccttga ctcatctttc tctgtcatag caaacaaaaa cacaccgtcg     1860

cttgccgtca gagacccgag tgtttttacg ccttatagtc tggttccttc agtggagtct     1920

tcacttttct ctgaccaaga acgttccagt ttttctgagc ataaacccag aggtgctttg     1980

gattttgcat ccagcttttt ctcaacaccc ccgctggaac tcagcggctc catctcttcg     2040

ccttcggaag cacctgcgtc tctgtctctg atgccgagtg acttgtcccc cttcacatct     2100

cagtcttttt ctcccttggt tgagacattt acattgtttg actctagtga tctgcagtca     2160

tctcagctgt ctcttcccag ttccacaaat cttgagtttt cgcagctcca gccaagttcc     2220

gagctgcctt taaacaccat catgttgcta cctagccgtt ctgaggtgtc accatggtca     2280

agcttccctt ctgattctct cgagtttgtt gaagcgtcta cggtttcact gacggattca     2340

gaagctcatt ttacctcagc tttcattgaa actacctcct atcttgagtc ttcactcatt     2400

tcccatgaat ccgcagtcac tgcactggtg ccccccggct ctgagtcttt tgacattttg     2460

actgccggga ttcaagcaac atcaccattg accactgtcc acacaacgcc cattttaact     2520

gagtcttctt tgttctcaac tctgacacct cctgacgacc aaatcagtgc tctagacggt     2580

cacgtgtctg tcctggcctc tttctccaaa gccattccca ctggtacggt gttgatcact     2640

gacgcgtacc tgccatcagg atcctcgttt gtttctgaag caaccccctt ccctctgccc     2700

acagagctga ccgtcgtggg cccatcactc acacccacag aggtgccact gaacacctcc     2760

acggaagtga gcacaaccag caccggtgct gccactggtg gtcccctcga ctccaccctg     2820

atgggtgacg ccgcaagtca gagcccccca gagagtagtg ctgctcctcc cctgccatcc     2880

ctgcgtcccg tgactgcctt cactctcgaa gcaacagtcg acacaccaac actggctact     2940

gccaagccgc catatgtttg tgatatcaca gtccccgatg cctatctgat cacaactgtg     3000

ctggccagaa gagctgtgca ggagtacatc attacagcaa tcaaagaagt actgaggatt     3060

cacttcaacc gtgcagtgga actgaaggtt tacgaactat ttactgactt cacttttctg     3120

gtaacatccg gtcctttcgt ttacacggca atatccgtca taaatgtgct tataaacagt     3180

aagcttgtcc gtgaccagac tcctttaatc ctgtctgtga aaccttcttt ccttgtgcca     3240

gagtccaggt tccaagttca aacagtactt cagtttgtgc ctccgagtgt ggatactggc     3300

ttctgcaact tcacccagcg cattgagaaa ggcctaatga cagctctctt tgaagtgaga     3360

aaacaccacc agggaacgta taacctcacg gtgcagatct tgaatatcac catcagttcc     3420

tcaagggtga ctcctcggcg gggcccggtg aatatcatct ttgcggttaa aagcacacag     3480

ggatttttga atgggtcgga agtgagcgag ctgctcagaa acttgagtgt ggtggagttc     3540

agtttctatc tgggataccc agtgctgcag atcgcagagc ccttccagta tccacagctc     3600

aacttatctc agttgctgaa gtcctcttgg gtcagaacag ttctcctggg cgtcatggag     3660

aagcaactcc agaatgaagt gtttcaagcc gagatggaac gcaagctggc ccagctgctc     3720

agcgaggttt ccaccagaag gcggatgtgg agaagggcca ctgtagctgc agggaacagt     3780

gtggtgcagg tggtaaatgt gtcgaggctg gagggagatg acaatccggt acagctcatc     3840

tactttgtgg aggatcaaga tggagaaaga ctcagtgcag tcaagtcttc ggacctgatt     3900

aacaaaatgg acctccagag agcagccatc atcttgggtt accgaattca aggtgtcatt     3960

gcccagcctg tcgacagggt gaagaggccg tctccggaat cccagagcaa caacttgtgg     4020

gtcattgttg gcgtggtcat cccagtgctg gtggtgatgg tgattgttgt catcctctac     4080

tggaaactat gccgcacaga caagctagac tttcagcctg acactgtggc caacattcag     4140

cagcgtcaga agctgcagat ccctagtgtg aagggcttcg attttgctaa gcagcatctg     4200

ggtcagcaca ataaagacga catattgatt attcatgagc cagcgccact gccaggacct     4260

ctgaaggacc acaccacgcc ctcggaaaat ggagacgtgc caagccccaa gtcaaagatc     4320

ccttccaaga atgttcgtca cagaggaaga gtttctccct cagatgctga ctctacggtc     4380

agtgaagagt ccagcgagag ggacgcagga gataagacgc cgggagccgt caacgatggc     4440

aggtcccaca gagctccgca gagcgggcca ccactgccca gttcgggaaa tgagcagcac     4500

tcatcagcct ccatcttcga gcacgtggac aggatctccc gccccccgga ggctagccgg     4560

cgggtcccca gtaagatcca gcttatcgcc atgcagccga tcccggcacc tcccgtccag     4620

cgcccctccc cagccgaccg agtggcggaa agcaataaaa tcaacaaaga gattcagacc     4680

gcgctgcggc acaagtctga gatcgagcac catcgcaaca agatccgcct gcgcgccaag     4740

cgccgcgggc actacgagtt cccggtggta gacgacctgt cctcgggcga cactaaggag     4800

cgacaccggg tgtaccgcag ggcacagatg cagatcgaca agatcctgga ccccacggcc     4860

agcgtgccct ccgtgttcat agagcccagg aagagctcac ggataaaacg ttctcccaag     4920

cctcgccgga aacaccaggt caacggctgt cctgccgacg ctgagaagga ccggctcatc     4980

accacagaca gcgatggcac ctacaggagg ccccccggcg tccacaactc agcctacatc     5040

ggatgcccat cggatcctga cctcccagcc gatgtgcaga caccatcctc ggtggaactg     5100

gggaggtatc cagcccttcc cttcccggcc tcccagtaca tcccacccca gccgtccatc     5160

gaggaggcac gccagaccat gcactccctc ctggacgacg cctttgccct cgtggccccc     5220

agcagccagc ctgccagcac cgcaggtgta ggccccggag tcccacccgg cctgcccgca     5280

aacagcaccc cttcccagga agagaggcga gccacccagt gggggtcctt ctacagccca     5340

gcccagacgg ccaacaatcc ctgcagtaga tacgaagact atggaatgac tcccccgacg     5400

ggtccattgc caagaccagg ttttggcccc ggtttgctgc agtctacaga gctggtgccc     5460

cctgaccctc agcagccaca ggcctccgcc gaagccccat ttgctgccag agggatctac     5520

tcggaggaga tgccgtcggt ggcccggcct cggcctgtcg ggggtaccac aggctcccag     5580

atccagcacc tgacacaggt ggggattgcc agcagaattg gagctcagcc agtggaaatc     5640

ccgccaagca gaggcagcca gtatgggggg ccaggctggc cttcgtacgg ggaggacgaa     5700

gcggggcgaa gagaggccac acacatgctc ggacatcaag agtattcttc ttcaccgcta     5760

tttcaggtgc caaggacttc aggcagggag ccctcagctc cttccgggaa cctcccccac     5820

cggggactgc agggccctgg gctgggttac cccaccagct ccacggaaga cctccagcct     5880

ggccactcct cggcctctct catcaaagca atccgcgagg agctcctccg gctctcccag     5940

aaacagagca ccgtgcagaa cttccacagc tgatcggcct cgcctcgcag atttgccaag     6000

tatccgcttc ctgtggaagc aagaccaaaa ggaaatcaac tgagtgggtg tttggaagag     6060

gaaggagcaa ctctcgggca gcctgcccaa gggagggagc aagttgcaat ttagaagatg     6120

ccatacgtcg tgtgacagct catgagcctt tcactgggct ggcaattgtc tgaacacttg     6180

ggttcagttg aaatatatgt attttggcca aaagccagca gcacttcaca aaaacaaaac     6240

acaaacctaa gctaacaaaa tgactgcatt cgtctctttt ttaaaggtag agattaaact     6300

gtatagacag catagggatg aaaggaacca agcgtttctg tgggattgag actggtacgt     6360

gtacgatgaa cctgctgctt tgttttctga gaagaggttt gaagacattt tattaacagc     6420

ttaatttttc tcttttactc cataggaact tattttaata gtaacattaa caacaagaat     6480

actaagactg tttgggaatt ttaaaaagct actagtgaga aaccaaatga taggttgtag     6540

agcctgatga ctccaaacaa agccatcacc cgcattcttc ctccttcttc tggtgctaca     6600

gctccaaggg cccttcacct tcatgtctga aatggaactt tggctttttc agtggaagaa     6660

tatgttgaag gtttcatttt gttctagaaa aaaaaaatcc ctcccaaagt ggggcaaaaa     6720

gctttatatt tatttgatta tccaaaatac agatcaaagt ttagatctac attcttcatt     6780

gtatttgctg tttcttaatt gggcacacac aactcctggt catgtcccag ttcagcaccg     6840

atcgctaagg ccgatcctgt agaatgcggc tttcaagagg tcctaactga tcctttcttc     6900

cactttgctg ttgatttgtt cacaaattat gtctgaatga gaaatcttct gtaagcagaa     6960

gttatttaat aattcccagc accacgaaat tgttatacat acatccctac cagtcacatt     7020

ccctgtgttc agagcctgga aatgaaattg agttcagttc agcctctctg taatgaatca     7080

agaaatgtaa aagagctttg agaccccaag ggaaaggaga gagttgcttc tcatttctga     7140

ttttattgtg ctgttactct gtcgagtggc tattaaaatt gtcttatgct ctttgggcta     7200

agaggggatc atctcgctta agatgtactc ctgatgtaaa catttccccc actttccaaa     7260

taatggtaaa gaaaacagtg gcaagggctg ttctgttttc tggtacctga gtgaaactca     7320

gaagaaaagc aggcttagct aagagatttt cactattaac ctgtttttat tagatcagcg     7380

aagacagtca tgcatcgctt aatgatgggg atgcattctg agaaatgtgt cattaggctg     7440

ttttgttgct gtgccaacat cctagattgt acttacacaa cctacatggt atagcctact     7500

acacacctgg gctgtgtggc atggcctatt cctcttaggc tacaaacctg tacagcatgt     7560

tactgtactg aacacaatgg taagtatttg tgtatctaaa catagctaaa catagaaaag     7620

gtatggtaaa aatacaattt tataatctta tgggactacc atcaatatgt agaccgtcat     7680

tgaccaaaac atcctgatgt gtgcatgact gtacttttca ttaaataaca gataaggggc     7740

tatagaattt ggggctctga ctgatcaaaa cctgtgtatc tgtgtcaagt tttaagaccc     7800

ctgaaacagc taaaacaggt ttccaaagtg taatcactgg atttcaaaac catgttttag     7860

cccttcatta atgaagcctg ttgtacagat ttagagtctt acaatatgag ggaagttggt     7920

tctgggaagg taagatgtag ccagttttca tctgggcacc tctgaaagag aaggagtgca     7980

ggagagtaag tctctcaagg acgttcaaca aaggaccagc agcatcttat caggcgatcc     8040

tcagaggctc caaggagcat tggagagaat gcccctttct gggcttgatg tcttggtttt     8100

ggtttaatac caaatttctc ttggtcttgg tttaataccc gactcctccc aaattgaacg     8160

attatctttg tatgtcactc aaaaatacca ggtttcctga atatgttatt aagaatttca     8220

gatatccaag cagaatttta ttatggacac cttgtaatga attcaaatcg tgtgacagca     8280

aacgggataa atggcccctt ctcacccagt tccgctcagg gccatacagg cttgcacata     8340

gagtgtgcta aaaatggtaa cctcctttga gcattgcaga aagagggttc tgtttcaaat     8400

tgggctgacc gtaaaagcaa ttttgatgtc tttcaaacta ccataaaggg attttaactg     8460

tatttttatt cttagaaaca atacaccttt aaacagatgt caagaccaaa gatgatgtat     8520

aataaacagc cggtggttat ggtgtggtgt gagcaggccc ccggatcacc agccctctgc     8580

tggtggtcat aaagcacaca cagtttgtac ttgcttcctc tcgacgcctg ccacaacagt     8640

tttgccagtc accaaactca gaaaaaacta gctgtgtgag cagcaccgta ccctagcggt     8700

cttcagacat taagttcacg tcatccactg aaaggaaggg tccttgcgtt gacagcgtgt     8760

ggctttggag tccgtttatg gaagcactct acaatgaaca gttgaatttt atgtctattc     8820

ttttttccta ttttaaaagt tctagtggta acacaaactg taaatttgag tcagaatgtt     8880

tggagaaatg ttgttttttt ttttttcaga gactactttg tcactcactg accatgtctg     8940

gttccttctc tgaacttcat tctccccata agccaaacaa gaacagacct cccccgccac     9000

ctcccaggca ccgtagttgt gagaatcaga tgtgatcatg tgtgcagatg tcctgtgagg     9060

agggagcata aagcactgtg aaaatgtagc atgctgtcta tgtggacgcc ctaggatgag     9120

tgatgtgaaa cgctgcacta ctgcggtgaa tgggttcaca catgggtaat gagcaaaacc     9180

gaaagctcgg tgtgactcag tttcctcact cccattttgc tttaatttca cttccttcac     9240

caattttccg attgcattta ttaagcatct ttctgctccc gactttctgg tgtctctggc     9300

accaaataac ccagcagaca tgagccttgc cttctgagat tttagaatct aagatagcac     9360

gagtgggtat agaagatgga agataccgat aaataacatg gtttaagtgt caataaaatt     9420

cattcgaaga gatcaggcgc ggtggctcac gcctgtaatc ccagcatttt gggaggctga     9480

ggcaggtgga tcacttgaga tcaagagctt aaaaccagcc caggcaacat ggcaaaaccc     9540

cgtctctaca aaaaaataca aaaactagct gggtgtggtg gcgcatgcct gtagtcccag     9600

ctgaggcacg ataattgctt gaacccgggg ggtggaggtt gcagtgagct gagattgcac     9660

cactgtactc caacctgggc gacagagcaa gactgtgtct caaaaagaaa aaaatttgtt     9720

caaaagacat aaatgaatta ggcacccaga agaagttgca tgtttggaaa tgcaatatct     9780

tggggagacg tcaacttctg aagtgacttt gaaggcaggg cagctaccca ggcaaatggc     9840

gtggaaggaa gagctgagag tgggcctggg aaaggctgta gggaaggagt gaagctgtca     9900

ctgaaatgaa cttgatcttg atctgctttg atatggggac agaatccccg actgcactat     9960

tgagggagtt tcagaagaga aggaagaggt gctggaagga tgcttttgca gtcatgcagc    10020

aaggaaacga ccagggctgt gaagatctac agaggaagta ctccagtgtg ggggaggcaa    10080

gggaagagga cgaaaatgat gagaatgaca ctgaggtcat tgtttagagc agatctcaag    10140

cagccgtttg gccacgccat atcctttgtg gagcatagtg ggttatctat ctgtctgtct    10200

gtctatgtat ctgtctatct atctatatat atattcagct tctttactgc tacctacaca    10260

tttttctcca aattttatta atttcatagt gttttgattt gggtggcaga tgacttttaa    10320

gcagtgggtg tttgccggcc agatctttcc tggcatgcgg actgtgaggc aaagcacggg    10380

tgaaggtagg cgctaaaggc tttgggctaa agccagcacg cggttctgtg ctataggagt    10440

ctcccgtttc ccgtggacag gttcagcgtt ccttctttcg cacaactttt ttctaagtgt    10500

tccagtgacc aagccagtca ttcggacact gatttgcagt gcattggcag taattcacaa    10560

attagttgtt atataagtct ctctcatccc tttcacacta gattctcaga catgaatgaa    10620

tttgtcgttt ggaaggaaag ctgggtaacg ttttgggcac aggggaagga ggactccggt    10680

cttaactccc acgctaactt tagctcaagt ggagttttca ccgtggtcat ttctacctcc    10740

ggagcaaggt gccagcgcca gtactagagc ctgcttatcc acatttgccc tggacaggag    10800

caggaggaag tccacttctg taccggcaga cagagcatgt gaacacaaaa cacatttcta    10860

tggcatagtc aactgaactt catttttaca tttaatctaa catgttaaca cgttctaaca    10920

gggtttctat gagcagctgc tgtaacatac tcatcaacta tgatagactt aacacttgtt    10980

acctaatgaa caaggaggat gtgcatttcg ggtttctttt gatattcgtg gaggtgattg    11040

tcagtgttta aacaggacta ctttctccac tatgaagatg acttggaaat cgcaacatca    11100

tggtacattg ctaagtccat gcttgtgtgt gtgacagtag gcttgataat ttatcttaaa    11160

acacagcagc attgaaattt aggaaaagaa tattaaatgc ctttggaaac atgaaacaaa    11220

gttaggagcc agtaagaaag tgacagaagc aatgaatgtc ttaatgcagt atagttaaaa    11280

tggcttccca cagggtagat aattatccag gatccttcct tttccttctt cctccaggtt    11340

tttcaggggt cacttcacat ttctaaagaa agagtgaata ggctgggcat ggtggctcaa    11400

gcctctaatc tcaacgcttt gggaggctga ggcaggagga tcgcttgagg ccaggagttt    11460

gagaccacct tgggcaacat aacgagaccc cgtctctaca aaaaaaattt aaaaattagc    11520

tgagcatggt ggcatgtgcc agtagtccca gctactcgaa aggctaagac tggaggatcg    11580

cttgagccaa tgagttggag gctgcagtga gctataatca cgccactgca ctccagcctg    11640

ggctgcaggg tgaggtcctg tctctggaaa aaaaaaaaaa aaaaaaagga ataggtaaaa    11700

gggacagagg tgaaattttg agtgacttga gtctcttgca gtccctgatt acacagaacc    11760

tttctgggct acttggagca tcacgaatag tctttcctgt acttaccaga tttcaagtat    11820

tcataacttg actccctaag tgtacaagtt gggaatagta cagggccaag ttcaagtcgc    11880

atatgctgta ctgttcctcc tgcaaatgtg gggaaagaag agggagatac tagaggaact    11940

gaggctccac ccattcattc agttgctcta agcaccagag gacttgtttc agaaaagggg    12000

agtgggaacg ccctcgactt tgccctcctc cggagcatct ctgggacgca gggagtctgg    12060

ctagcgttaa taggaaaggt tgctcggcag agctgccctg gagtactgac ttgtctctcc    12120

ctcctttgtc aaggtccatg tttttctggc tcttcctgca cactcatccc tagattatga    12180

gcgttaatgt acgaaatgtg cagagcaaat tgaggccaac tgtggcatca atactgcaac    12240

ttaaacttga caatcatggt ttgctggtcc tcaaacaggc actgaaatct cagtatgggt    12300

atacgattta ataatcggcc cctcccttct atttgtcggt tttatgtttc tatccttcaa    12360

tagctgcact gttttctaat gtgctgtaga gtttttgaaa taatttatgc aagtatttgg    12420

tttccatgtt tacaatttat acagctttcc tagcatttta aatggaaatg tcaataaatg    12480

ctatgaattg gtgtcaaa                                                  12498


<210>  55
<211>  1934
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Pro Gly Ala Arg Arg Arg Arg Arg Gly Ala Ala Met Glu Gly Lys 
1               5                   10                  15      


Pro Arg Ala Gly Val Ala Leu Ala Pro Gly Pro Ser Gly Arg Arg Pro 
            20                  25                  30          


Ser Ala Arg Cys Ala Arg Arg Arg Arg Pro Gly Leu Leu Leu Pro Gly 
        35                  40                  45              


Leu Trp Leu Leu Leu Leu Ala Arg Pro Ala Ser Cys Ala Pro Asp Glu 
    50                  55                  60                  


Leu Ser Pro Glu Gln His Asn Leu Ser Leu Tyr Ser Met Glu Leu Val 
65                  70                  75                  80  


Leu Lys Lys Ser Thr Gly His Ser Ala Ala Gln Val Ala Leu Thr Glu 
                85                  90                  95      


Thr Ala Pro Gly Ser Gln His Ser Ser Pro Leu His Val Thr Ala Pro 
            100                 105                 110         


Pro Ser Ala Thr Thr Phe Asp Thr Ala Phe Phe Asn Gln Gly Lys Gln 
        115                 120                 125             


Thr Lys Ser Thr Ala Asp Pro Ser Ile Phe Val Ala Thr Tyr Val Ser 
    130                 135                 140                 


Val Thr Ser Lys Glu Val Ala Val Asn Asp Asp Glu Met Asp Asn Phe 
145                 150                 155                 160 


Leu Pro Asp Thr His Trp Thr Thr Pro Arg Met Val Ser Pro Ile Gln 
                165                 170                 175     


Tyr Ile Thr Val Ser Pro Pro Gly Leu Pro Arg Glu Ala Leu Glu Pro 
            180                 185                 190         


Met Leu Thr Pro Ser Leu Pro Met Val Ser Leu Gln Asp Glu Glu Val 
        195                 200                 205             


Thr Ser Gly Trp Gln Asn Thr Thr Arg Gln Pro Ala Ala Tyr Ala Glu 
    210                 215                 220                 


Ser Ala Ser His Phe His Thr Phe Arg Ser Ala Phe Arg Thr Ser Glu 
225                 230                 235                 240 


Gly Ile Val Pro Thr Pro Gly Arg Asn Leu Val Leu Tyr Pro Thr Asp 
                245                 250                 255     


Ala Tyr Ser His Leu Ser Ser Arg Thr Leu Pro Glu Ile Val Ala Ser 
            260                 265                 270         


Leu Thr Glu Gly Val Glu Thr Thr Leu Phe Leu Ser Ser Arg Ser Leu 
        275                 280                 285             


Met Pro Gln Pro Leu Gly Asp Gly Ile Thr Ile Pro Leu Pro Ser Leu 
    290                 295                 300                 


Gly Glu Val Ser Gln Pro Pro Glu Glu Val Trp Ala Thr Ser Ala Asp 
305                 310                 315                 320 


Arg Tyr Thr Asp Val Thr Thr Val Leu Ser Gln Ser Leu Glu Glu Thr 
                325                 330                 335     


Ile Ser Pro Arg Thr Tyr Pro Thr Val Thr Ala Ser His Ala Ala Leu 
            340                 345                 350         


Ala Phe Ser Arg Thr His Ser Pro Leu Leu Ser Thr Pro Leu Ala Phe 
        355                 360                 365             


Ala Ser Ser Ala Ser Pro Thr Asp Val Ser Ser Asn Pro Phe Leu Pro 
    370                 375                 380                 


Ser Asp Ser Ser Lys Thr Ser Glu Leu His Ser Asn Ser Ala Leu Pro 
385                 390                 395                 400 


Gly Pro Val Asp Asn Thr His Ile Leu Ser Pro Val Ser Ser Phe Arg 
                405                 410                 415     


Pro Tyr Thr Trp Cys Ala Ala Cys Thr Val Pro Ser Pro Gln Gln Val 
            420                 425                 430         


Leu Ala Thr Ser Leu Met Glu Lys Asp Val Gly Ser Gly Asp Gly Ala 
        435                 440                 445             


Glu Thr Leu Cys Met Thr Val Leu Glu Glu Ser Ser Ile Ser Leu Met 
    450                 455                 460                 


Ser Ser Val Val Ala Asp Phe Ser Glu Phe Glu Glu Asp Pro Gln Val 
465                 470                 475                 480 


Phe Asn Thr Leu Phe Pro Ser Arg Pro Ile Val Pro Leu Ser Ser Arg 
                485                 490                 495     


Ser Met Glu Ile Ser Glu Thr Ser Val Gly Ile Ser Ala Glu Val Asp 
            500                 505                 510         


Met Ser Ser Val Thr Thr Thr Gln Val Pro Pro Ala His Gly Arg Leu 
        515                 520                 525             


Ser Val Pro Ala Ser Leu Asp Pro Thr Ala Gly Ser Leu Ser Val Ala 
    530                 535                 540                 


Glu Thr Gln Val Thr Pro Ser Ser Val Thr Thr Ala Phe Phe Ser Val 
545                 550                 555                 560 


Ile Thr Ser Ile Leu Leu Asp Ser Ser Phe Ser Val Ile Ala Asn Lys 
                565                 570                 575     


Asn Thr Pro Ser Leu Ala Val Arg Asp Pro Ser Val Phe Thr Pro Tyr 
            580                 585                 590         


Ser Leu Val Pro Ser Val Glu Ser Ser Leu Phe Ser Asp Gln Glu Arg 
        595                 600                 605             


Ser Ser Phe Ser Glu His Lys Pro Arg Gly Ala Leu Asp Phe Ala Ser 
    610                 615                 620                 


Ser Phe Phe Ser Thr Pro Pro Leu Glu Leu Ser Gly Ser Ile Ser Ser 
625                 630                 635                 640 


Pro Ser Glu Ala Pro Ala Ser Leu Ser Leu Met Pro Ser Asp Leu Ser 
                645                 650                 655     


Pro Phe Thr Ser Gln Ser Phe Ser Pro Leu Val Glu Thr Phe Thr Leu 
            660                 665                 670         


Phe Asp Ser Ser Asp Leu Gln Ser Ser Gln Leu Ser Leu Pro Ser Ser 
        675                 680                 685             


Thr Asn Leu Glu Phe Ser Gln Leu Gln Pro Ser Ser Glu Leu Pro Leu 
    690                 695                 700                 


Asn Thr Ile Met Leu Leu Pro Ser Arg Ser Glu Val Ser Pro Trp Ser 
705                 710                 715                 720 


Ser Phe Pro Ser Asp Ser Leu Glu Phe Val Glu Ala Ser Thr Val Ser 
                725                 730                 735     


Leu Thr Asp Ser Glu Ala His Phe Thr Ser Ala Phe Ile Glu Thr Thr 
            740                 745                 750         


Ser Tyr Leu Glu Ser Ser Leu Ile Ser His Glu Ser Ala Val Thr Ala 
        755                 760                 765             


Leu Val Pro Pro Gly Ser Glu Ser Phe Asp Ile Leu Thr Ala Gly Ile 
    770                 775                 780                 


Gln Ala Thr Ser Pro Leu Thr Thr Val His Thr Thr Pro Ile Leu Thr 
785                 790                 795                 800 


Glu Ser Ser Leu Phe Ser Thr Leu Thr Pro Pro Asp Asp Gln Ile Ser 
                805                 810                 815     


Ala Leu Asp Gly His Val Ser Val Leu Ala Ser Phe Ser Lys Ala Ile 
            820                 825                 830         


Pro Thr Gly Thr Val Leu Ile Thr Asp Ala Tyr Leu Pro Ser Gly Ser 
        835                 840                 845             


Ser Phe Val Ser Glu Ala Thr Pro Phe Pro Leu Pro Thr Glu Leu Thr 
    850                 855                 860                 


Val Val Gly Pro Ser Leu Thr Pro Thr Glu Val Pro Leu Asn Thr Ser 
865                 870                 875                 880 


Thr Glu Val Ser Thr Thr Ser Thr Gly Ala Ala Thr Gly Gly Pro Leu 
                885                 890                 895     


Asp Ser Thr Leu Met Gly Asp Ala Ala Ser Gln Ser Pro Pro Glu Ser 
            900                 905                 910         


Ser Ala Ala Pro Pro Leu Pro Ser Leu Arg Pro Val Thr Ala Phe Thr 
        915                 920                 925             


Leu Glu Ala Thr Val Asp Thr Pro Thr Leu Ala Thr Ala Lys Pro Pro 
    930                 935                 940                 


Tyr Val Cys Asp Ile Thr Val Pro Asp Ala Tyr Leu Ile Thr Thr Val 
945                 950                 955                 960 


Leu Ala Arg Arg Ala Val Gln Glu Tyr Ile Ile Thr Ala Ile Lys Glu 
                965                 970                 975     


Val Leu Arg Ile His Phe Asn Arg Ala Val Glu Leu Lys Val Tyr Glu 
            980                 985                 990         


Leu Phe Thr Asp Phe Thr Phe Leu  Val Thr Ser Gly Pro  Phe Val Tyr 
        995                 1000                 1005             


Thr Ala  Ile Ser Val Ile Asn  Val Leu Ile Asn Ser  Lys Leu Val 
    1010                 1015                 1020             


Arg Asp  Gln Thr Pro Leu Ile  Leu Ser Val Lys Pro  Ser Phe Leu 
    1025                 1030                 1035             


Val Pro  Glu Ser Arg Phe Gln  Val Gln Thr Val Leu  Gln Phe Val 
    1040                 1045                 1050             


Pro Pro  Ser Val Asp Thr Gly  Phe Cys Asn Phe Thr  Gln Arg Ile 
    1055                 1060                 1065             


Glu Lys  Gly Leu Met Thr Ala  Leu Phe Glu Val Arg  Lys His His 
    1070                 1075                 1080             


Gln Gly  Thr Tyr Asn Leu Thr  Val Gln Ile Leu Asn  Ile Thr Ile 
    1085                 1090                 1095             


Ser Ser  Ser Arg Val Thr Pro  Arg Arg Gly Pro Val  Asn Ile Ile 
    1100                 1105                 1110             


Phe Ala  Val Lys Ser Thr Gln  Gly Phe Leu Asn Gly  Ser Glu Val 
    1115                 1120                 1125             


Ser Glu  Leu Leu Arg Asn Leu  Ser Val Val Glu Phe  Ser Phe Tyr 
    1130                 1135                 1140             


Leu Gly  Tyr Pro Val Leu Gln  Ile Ala Glu Pro Phe  Gln Tyr Pro 
    1145                 1150                 1155             


Gln Leu  Asn Leu Ser Gln Leu  Leu Lys Ser Ser Trp  Val Arg Thr 
    1160                 1165                 1170             


Val Leu  Leu Gly Val Met Glu  Lys Gln Leu Gln Asn  Glu Val Phe 
    1175                 1180                 1185             


Gln Ala  Glu Met Glu Arg Lys  Leu Ala Gln Leu Leu  Ser Glu Val 
    1190                 1195                 1200             


Ser Thr  Arg Arg Arg Met Trp  Arg Arg Ala Thr Val  Ala Ala Gly 
    1205                 1210                 1215             


Asn Ser  Val Val Gln Val Val  Asn Val Ser Arg Leu  Glu Gly Asp 
    1220                 1225                 1230             


Asp Asn  Pro Val Gln Leu Ile  Tyr Phe Val Glu Asp  Gln Asp Gly 
    1235                 1240                 1245             


Glu Arg  Leu Ser Ala Val Lys  Ser Ser Asp Leu Ile  Asn Lys Met 
    1250                 1255                 1260             


Asp Leu  Gln Arg Ala Ala Ile  Ile Leu Gly Tyr Arg  Ile Gln Gly 
    1265                 1270                 1275             


Val Ile  Ala Gln Pro Val Asp  Arg Val Lys Arg Pro  Ser Pro Glu 
    1280                 1285                 1290             


Ser Gln  Ser Asn Asn Leu Trp  Val Ile Val Gly Val  Val Ile Pro 
    1295                 1300                 1305             


Val Leu  Val Val Met Val Ile  Val Val Ile Leu Tyr  Trp Lys Leu 
    1310                 1315                 1320             


Cys Arg  Thr Asp Lys Leu Asp  Phe Gln Pro Asp Thr  Val Ala Asn 
    1325                 1330                 1335             


Ile Gln  Gln Arg Gln Lys Leu  Gln Ile Pro Ser Val  Lys Gly Phe 
    1340                 1345                 1350             


Asp Phe  Ala Lys Gln His Leu  Gly Gln His Asn Lys  Asp Asp Ile 
    1355                 1360                 1365             


Leu Ile  Ile His Glu Pro Ala  Pro Leu Pro Gly Pro  Leu Lys Asp 
    1370                 1375                 1380             


His Thr  Thr Pro Ser Glu Asn  Gly Asp Val Pro Ser  Pro Lys Ser 
    1385                 1390                 1395             


Lys Ile  Pro Ser Lys Asn Val  Arg His Arg Gly Arg  Val Ser Pro 
    1400                 1405                 1410             


Ser Asp  Ala Asp Ser Thr Val  Ser Glu Glu Ser Ser  Glu Arg Asp 
    1415                 1420                 1425             


Ala Gly  Asp Lys Thr Pro Gly  Ala Val Asn Asp Gly  Arg Ser His 
    1430                 1435                 1440             


Arg Ala  Pro Gln Ser Gly Pro  Pro Leu Pro Ser Ser  Gly Asn Glu 
    1445                 1450                 1455             


Gln His  Ser Ser Ala Ser Ile  Phe Glu His Val Asp  Arg Ile Ser 
    1460                 1465                 1470             


Arg Pro  Pro Glu Ala Ser Arg  Arg Val Pro Ser Lys  Ile Gln Leu 
    1475                 1480                 1485             


Ile Ala  Met Gln Pro Ile Pro  Ala Pro Pro Val Gln  Arg Pro Ser 
    1490                 1495                 1500             


Pro Ala  Asp Arg Val Ala Glu  Ser Asn Lys Ile Asn  Lys Glu Ile 
    1505                 1510                 1515             


Gln Thr  Ala Leu Arg His Lys  Ser Glu Ile Glu His  His Arg Asn 
    1520                 1525                 1530             


Lys Ile  Arg Leu Arg Ala Lys  Arg Arg Gly His Tyr  Glu Phe Pro 
    1535                 1540                 1545             


Val Val  Asp Asp Leu Ser Ser  Gly Asp Thr Lys Glu  Arg His Arg 
    1550                 1555                 1560             


Val Tyr  Arg Arg Ala Gln Met  Gln Ile Asp Lys Ile  Leu Asp Pro 
    1565                 1570                 1575             


Thr Ala  Ser Val Pro Ser Val  Phe Ile Glu Pro Arg  Lys Ser Ser 
    1580                 1585                 1590             


Arg Ile  Lys Arg Ser Pro Lys  Pro Arg Arg Lys His  Gln Val Asn 
    1595                 1600                 1605             


Gly Cys  Pro Ala Asp Ala Glu  Lys Asp Arg Leu Ile  Thr Thr Asp 
    1610                 1615                 1620             


Ser Asp  Gly Thr Tyr Arg Arg  Pro Pro Gly Val His  Asn Ser Ala 
    1625                 1630                 1635             


Tyr Ile  Gly Cys Pro Ser Asp  Pro Asp Leu Pro Ala  Asp Val Gln 
    1640                 1645                 1650             


Thr Pro  Ser Ser Val Glu Leu  Gly Arg Tyr Pro Ala  Leu Pro Phe 
    1655                 1660                 1665             


Pro Ala  Ser Gln Tyr Ile Pro  Pro Gln Pro Ser Ile  Glu Glu Ala 
    1670                 1675                 1680             


Arg Gln  Thr Met His Ser Leu  Leu Asp Asp Ala Phe  Ala Leu Val 
    1685                 1690                 1695             


Ala Pro  Ser Ser Gln Pro Ala  Ser Thr Ala Gly Val  Gly Pro Gly 
    1700                 1705                 1710             


Val Pro  Pro Gly Leu Pro Ala  Asn Ser Thr Pro Ser  Gln Glu Glu 
    1715                 1720                 1725             


Arg Arg  Ala Thr Gln Trp Gly  Ser Phe Tyr Ser Pro  Ala Gln Thr 
    1730                 1735                 1740             


Ala Asn  Asn Pro Cys Ser Arg  Tyr Glu Asp Tyr Gly  Met Thr Pro 
    1745                 1750                 1755             


Pro Thr  Gly Pro Leu Pro Arg  Pro Gly Phe Gly Pro  Gly Leu Leu 
    1760                 1765                 1770             


Gln Ser  Thr Glu Leu Val Pro  Pro Asp Pro Gln Gln  Pro Gln Ala 
    1775                 1780                 1785             


Ser Ala  Glu Ala Pro Phe Ala  Ala Arg Gly Ile Tyr  Ser Glu Glu 
    1790                 1795                 1800             


Met Pro  Ser Val Ala Arg Pro  Arg Pro Val Gly Gly  Thr Thr Gly 
    1805                 1810                 1815             


Ser Gln  Ile Gln His Leu Thr  Gln Val Gly Ile Ala  Ser Arg Ile 
    1820                 1825                 1830             


Gly Ala  Gln Pro Val Glu Ile  Pro Pro Ser Arg Gly  Ser Gln Tyr 
    1835                 1840                 1845             


Gly Gly  Pro Gly Trp Pro Ser  Tyr Gly Glu Asp Glu  Ala Gly Arg 
    1850                 1855                 1860             


Arg Glu  Ala Val Pro Arg Thr  Ser Gly Arg Glu Pro  Ser Ala Pro 
    1865                 1870                 1875             


Ser Gly  Asn Leu Pro His Arg  Gly Leu Gln Gly Pro  Gly Leu Gly 
    1880                 1885                 1890             


Tyr Pro  Thr Ser Ser Thr Glu  Asp Leu Gln Pro Gly  His Ser Ser 
    1895                 1900                 1905             


Ala Ser  Leu Ile Lys Ala Ile  Arg Glu Glu Leu Leu  Arg Leu Ser 
    1910                 1915                 1920             


Gln Lys  Gln Ser Thr Val Gln  Asn Phe His Ser 
    1925                 1930                 


<210>  56
<211>  1950
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Pro Gly Ala Arg Arg Arg Arg Arg Gly Ala Ala Met Glu Gly Lys 
1               5                   10                  15      


Pro Arg Ala Gly Val Ala Leu Ala Pro Gly Pro Ser Gly Arg Arg Pro 
            20                  25                  30          


Ser Ala Arg Cys Ala Arg Arg Arg Arg Pro Gly Leu Leu Leu Pro Gly 
        35                  40                  45              


Leu Trp Leu Leu Leu Leu Ala Arg Pro Ala Ser Cys Ala Pro Asp Glu 
    50                  55                  60                  


Leu Ser Pro Glu Gln His Asn Leu Ser Leu Tyr Ser Met Glu Leu Val 
65                  70                  75                  80  


Leu Lys Lys Ser Thr Gly His Ser Ala Ala Gln Val Ala Leu Thr Glu 
                85                  90                  95      


Thr Ala Pro Gly Ser Gln His Ser Ser Pro Leu His Val Thr Ala Pro 
            100                 105                 110         


Pro Ser Ala Thr Thr Phe Asp Thr Ala Phe Phe Asn Gln Gly Lys Gln 
        115                 120                 125             


Thr Lys Ser Thr Ala Asp Pro Ser Ile Phe Val Ala Thr Tyr Val Ser 
    130                 135                 140                 


Val Thr Ser Lys Glu Val Ala Val Asn Asp Asp Glu Met Asp Asn Phe 
145                 150                 155                 160 


Leu Pro Asp Thr His Trp Thr Thr Pro Arg Met Val Ser Pro Ile Gln 
                165                 170                 175     


Tyr Ile Thr Val Ser Pro Pro Gly Leu Pro Arg Glu Ala Leu Glu Pro 
            180                 185                 190         


Met Leu Thr Pro Ser Leu Pro Met Val Ser Leu Gln Asp Glu Glu Val 
        195                 200                 205             


Thr Ser Gly Trp Gln Asn Thr Thr Arg Gln Pro Ala Ala Tyr Ala Glu 
    210                 215                 220                 


Ser Ala Ser His Phe His Thr Phe Arg Ser Ala Phe Arg Thr Ser Glu 
225                 230                 235                 240 


Gly Ile Val Pro Thr Pro Gly Arg Asn Leu Val Leu Tyr Pro Thr Asp 
                245                 250                 255     


Ala Tyr Ser His Leu Ser Ser Arg Thr Leu Pro Glu Ile Val Ala Ser 
            260                 265                 270         


Leu Thr Glu Gly Val Glu Thr Thr Leu Phe Leu Ser Ser Arg Ser Leu 
        275                 280                 285             


Met Pro Gln Pro Leu Gly Asp Gly Ile Thr Ile Pro Leu Pro Ser Leu 
    290                 295                 300                 


Gly Glu Val Ser Gln Pro Pro Glu Glu Val Trp Ala Thr Ser Ala Asp 
305                 310                 315                 320 


Arg Tyr Thr Asp Val Thr Thr Val Leu Ser Gln Ser Leu Glu Glu Thr 
                325                 330                 335     


Ile Ser Pro Arg Thr Tyr Pro Thr Val Thr Ala Ser His Ala Ala Leu 
            340                 345                 350         


Ala Phe Ser Arg Thr His Ser Pro Leu Leu Ser Thr Pro Leu Ala Phe 
        355                 360                 365             


Ala Ser Ser Ala Ser Pro Thr Asp Val Ser Ser Asn Pro Phe Leu Pro 
    370                 375                 380                 


Ser Asp Ser Ser Lys Thr Ser Glu Leu His Ser Asn Ser Ala Leu Pro 
385                 390                 395                 400 


Gly Pro Val Asp Asn Thr His Ile Leu Ser Pro Val Ser Ser Phe Arg 
                405                 410                 415     


Pro Tyr Thr Trp Cys Ala Ala Cys Thr Val Pro Ser Pro Gln Gln Val 
            420                 425                 430         


Leu Ala Thr Ser Leu Met Glu Lys Asp Val Gly Ser Gly Asp Gly Ala 
        435                 440                 445             


Glu Thr Leu Cys Met Thr Val Leu Glu Glu Ser Ser Ile Ser Leu Met 
    450                 455                 460                 


Ser Ser Val Val Ala Asp Phe Ser Glu Phe Glu Glu Asp Pro Gln Val 
465                 470                 475                 480 


Phe Asn Thr Leu Phe Pro Ser Arg Pro Ile Val Pro Leu Ser Ser Arg 
                485                 490                 495     


Ser Met Glu Ile Ser Glu Thr Ser Val Gly Ile Ser Ala Glu Val Asp 
            500                 505                 510         


Met Ser Ser Val Thr Thr Thr Gln Val Pro Pro Ala His Gly Arg Leu 
        515                 520                 525             


Ser Val Pro Ala Ser Leu Asp Pro Thr Ala Gly Ser Leu Ser Val Ala 
    530                 535                 540                 


Glu Thr Gln Val Thr Pro Ser Ser Val Thr Thr Ala Phe Phe Ser Val 
545                 550                 555                 560 


Ile Thr Ser Ile Leu Leu Asp Ser Ser Phe Ser Val Ile Ala Asn Lys 
                565                 570                 575     


Asn Thr Pro Ser Leu Ala Val Arg Asp Pro Ser Val Phe Thr Pro Tyr 
            580                 585                 590         


Ser Leu Val Pro Ser Val Glu Ser Ser Leu Phe Ser Asp Gln Glu Arg 
        595                 600                 605             


Ser Ser Phe Ser Glu His Lys Pro Arg Gly Ala Leu Asp Phe Ala Ser 
    610                 615                 620                 


Ser Phe Phe Ser Thr Pro Pro Leu Glu Leu Ser Gly Ser Ile Ser Ser 
625                 630                 635                 640 


Pro Ser Glu Ala Pro Ala Ser Leu Ser Leu Met Pro Ser Asp Leu Ser 
                645                 650                 655     


Pro Phe Thr Ser Gln Ser Phe Ser Pro Leu Val Glu Thr Phe Thr Leu 
            660                 665                 670         


Phe Asp Ser Ser Asp Leu Gln Ser Ser Gln Leu Ser Leu Pro Ser Ser 
        675                 680                 685             


Thr Asn Leu Glu Phe Ser Gln Leu Gln Pro Ser Ser Glu Leu Pro Leu 
    690                 695                 700                 


Asn Thr Ile Met Leu Leu Pro Ser Arg Ser Glu Val Ser Pro Trp Ser 
705                 710                 715                 720 


Ser Phe Pro Ser Asp Ser Leu Glu Phe Val Glu Ala Ser Thr Val Ser 
                725                 730                 735     


Leu Thr Asp Ser Glu Ala His Phe Thr Ser Ala Phe Ile Glu Thr Thr 
            740                 745                 750         


Ser Tyr Leu Glu Ser Ser Leu Ile Ser His Glu Ser Ala Val Thr Ala 
        755                 760                 765             


Leu Val Pro Pro Gly Ser Glu Ser Phe Asp Ile Leu Thr Ala Gly Ile 
    770                 775                 780                 


Gln Ala Thr Ser Pro Leu Thr Thr Val His Thr Thr Pro Ile Leu Thr 
785                 790                 795                 800 


Glu Ser Ser Leu Phe Ser Thr Leu Thr Pro Pro Asp Asp Gln Ile Ser 
                805                 810                 815     


Ala Leu Asp Gly His Val Ser Val Leu Ala Ser Phe Ser Lys Ala Ile 
            820                 825                 830         


Pro Thr Gly Thr Val Leu Ile Thr Asp Ala Tyr Leu Pro Ser Gly Ser 
        835                 840                 845             


Ser Phe Val Ser Glu Ala Thr Pro Phe Pro Leu Pro Thr Glu Leu Thr 
    850                 855                 860                 


Val Val Gly Pro Ser Leu Thr Pro Thr Glu Val Pro Leu Asn Thr Ser 
865                 870                 875                 880 


Thr Glu Val Ser Thr Thr Ser Thr Gly Ala Ala Thr Gly Gly Pro Leu 
                885                 890                 895     


Asp Ser Thr Leu Met Gly Asp Ala Ala Ser Gln Ser Pro Pro Glu Ser 
            900                 905                 910         


Ser Ala Ala Pro Pro Leu Pro Ser Leu Arg Pro Val Thr Ala Phe Thr 
        915                 920                 925             


Leu Glu Ala Thr Val Asp Thr Pro Thr Leu Ala Thr Ala Lys Pro Pro 
    930                 935                 940                 


Tyr Val Cys Asp Ile Thr Val Pro Asp Ala Tyr Leu Ile Thr Thr Val 
945                 950                 955                 960 


Leu Ala Arg Arg Ala Val Gln Glu Tyr Ile Ile Thr Ala Ile Lys Glu 
                965                 970                 975     


Val Leu Arg Ile His Phe Asn Arg Ala Val Glu Leu Lys Val Tyr Glu 
            980                 985                 990         


Leu Phe Thr Asp Phe Thr Phe Leu  Val Thr Ser Gly Pro  Phe Val Tyr 
        995                 1000                 1005             


Thr Ala  Ile Ser Val Ile Asn  Val Leu Ile Asn Ser  Lys Leu Val 
    1010                 1015                 1020             


Arg Asp  Gln Thr Pro Leu Ile  Leu Ser Val Lys Pro  Ser Phe Leu 
    1025                 1030                 1035             


Val Pro  Glu Ser Arg Phe Gln  Val Gln Thr Val Leu  Gln Phe Val 
    1040                 1045                 1050             


Pro Pro  Ser Val Asp Thr Gly  Phe Cys Asn Phe Thr  Gln Arg Ile 
    1055                 1060                 1065             


Glu Lys  Gly Leu Met Thr Ala  Leu Phe Glu Val Arg  Lys His His 
    1070                 1075                 1080             


Gln Gly  Thr Tyr Asn Leu Thr  Val Gln Ile Leu Asn  Ile Thr Ile 
    1085                 1090                 1095             


Ser Ser  Ser Arg Val Thr Pro  Arg Arg Gly Pro Val  Asn Ile Ile 
    1100                 1105                 1110             


Phe Ala  Val Lys Ser Thr Gln  Gly Phe Leu Asn Gly  Ser Glu Val 
    1115                 1120                 1125             


Ser Glu  Leu Leu Arg Asn Leu  Ser Val Val Glu Phe  Ser Phe Tyr 
    1130                 1135                 1140             


Leu Gly  Tyr Pro Val Leu Gln  Ile Ala Glu Pro Phe  Gln Tyr Pro 
    1145                 1150                 1155             


Gln Leu  Asn Leu Ser Gln Leu  Leu Lys Ser Ser Trp  Val Arg Thr 
    1160                 1165                 1170             


Val Leu  Leu Gly Val Met Glu  Lys Gln Leu Gln Asn  Glu Val Phe 
    1175                 1180                 1185             


Gln Ala  Glu Met Glu Arg Lys  Leu Ala Gln Leu Leu  Ser Glu Val 
    1190                 1195                 1200             


Ser Thr  Arg Arg Arg Met Trp  Arg Arg Ala Thr Val  Ala Ala Gly 
    1205                 1210                 1215             


Asn Ser  Val Val Gln Val Val  Asn Val Ser Arg Leu  Glu Gly Asp 
    1220                 1225                 1230             


Asp Asn  Pro Val Gln Leu Ile  Tyr Phe Val Glu Asp  Gln Asp Gly 
    1235                 1240                 1245             


Glu Arg  Leu Ser Ala Val Lys  Ser Ser Asp Leu Ile  Asn Lys Met 
    1250                 1255                 1260             


Asp Leu  Gln Arg Ala Ala Ile  Ile Leu Gly Tyr Arg  Ile Gln Gly 
    1265                 1270                 1275             


Val Ile  Ala Gln Pro Val Asp  Arg Val Lys Arg Pro  Ser Pro Glu 
    1280                 1285                 1290             


Ser Gln  Ser Asn Asn Leu Trp  Val Ile Val Gly Val  Val Ile Pro 
    1295                 1300                 1305             


Val Leu  Val Val Met Val Ile  Val Val Ile Leu Tyr  Trp Lys Leu 
    1310                 1315                 1320             


Cys Arg  Thr Asp Lys Leu Asp  Phe Gln Pro Asp Thr  Val Ala Asn 
    1325                 1330                 1335             


Ile Gln  Gln Arg Gln Lys Leu  Gln Ile Pro Ser Val  Lys Gly Phe 
    1340                 1345                 1350             


Asp Phe  Ala Lys Gln His Leu  Gly Gln His Asn Lys  Asp Asp Ile 
    1355                 1360                 1365             


Leu Ile  Ile His Glu Pro Ala  Pro Leu Pro Gly Pro  Leu Lys Asp 
    1370                 1375                 1380             


His Thr  Thr Pro Ser Glu Asn  Gly Asp Val Pro Ser  Pro Lys Ser 
    1385                 1390                 1395             


Lys Ile  Pro Ser Lys Asn Val  Arg His Arg Gly Arg  Val Ser Pro 
    1400                 1405                 1410             


Ser Asp  Ala Asp Ser Thr Val  Ser Glu Glu Ser Ser  Glu Arg Asp 
    1415                 1420                 1425             


Ala Gly  Asp Lys Thr Pro Gly  Ala Val Asn Asp Gly  Arg Ser His 
    1430                 1435                 1440             


Arg Ala  Pro Gln Ser Gly Pro  Pro Leu Pro Ser Ser  Gly Asn Glu 
    1445                 1450                 1455             


Gln His  Ser Ser Ala Ser Ile  Phe Glu His Val Asp  Arg Ile Ser 
    1460                 1465                 1470             


Arg Pro  Pro Glu Ala Ser Arg  Arg Val Pro Ser Lys  Ile Gln Leu 
    1475                 1480                 1485             


Ile Ala  Met Gln Pro Ile Pro  Ala Pro Pro Val Gln  Arg Pro Ser 
    1490                 1495                 1500             


Pro Ala  Asp Arg Val Ala Glu  Ser Asn Lys Ile Asn  Lys Glu Ile 
    1505                 1510                 1515             


Gln Thr  Ala Leu Arg His Lys  Ser Glu Ile Glu His  His Arg Asn 
    1520                 1525                 1530             


Lys Ile  Arg Leu Arg Ala Lys  Arg Arg Gly His Tyr  Glu Phe Pro 
    1535                 1540                 1545             


Val Val  Asp Asp Leu Ser Ser  Gly Asp Thr Lys Glu  Arg His Arg 
    1550                 1555                 1560             


Val Tyr  Arg Arg Ala Gln Met  Gln Ile Asp Lys Ile  Leu Asp Pro 
    1565                 1570                 1575             


Thr Ala  Ser Val Pro Ser Val  Phe Ile Glu Pro Arg  Lys Ser Ser 
    1580                 1585                 1590             


Arg Ile  Lys Arg Ser Pro Lys  Pro Arg Arg Lys His  Gln Val Asn 
    1595                 1600                 1605             


Gly Cys  Pro Ala Asp Ala Glu  Lys Asp Arg Leu Ile  Thr Thr Asp 
    1610                 1615                 1620             


Ser Asp  Gly Thr Tyr Arg Arg  Pro Pro Gly Val His  Asn Ser Ala 
    1625                 1630                 1635             


Tyr Ile  Gly Cys Pro Ser Asp  Pro Asp Leu Pro Ala  Asp Val Gln 
    1640                 1645                 1650             


Thr Pro  Ser Ser Val Glu Leu  Gly Arg Tyr Pro Ala  Leu Pro Phe 
    1655                 1660                 1665             


Pro Ala  Ser Gln Tyr Ile Pro  Pro Gln Pro Ser Ile  Glu Glu Ala 
    1670                 1675                 1680             


Arg Gln  Thr Met His Ser Leu  Leu Asp Asp Ala Phe  Ala Leu Val 
    1685                 1690                 1695             


Ala Pro  Ser Ser Gln Pro Ala  Ser Thr Ala Gly Val  Gly Pro Gly 
    1700                 1705                 1710             


Val Pro  Pro Gly Leu Pro Ala  Asn Ser Thr Pro Ser  Gln Glu Glu 
    1715                 1720                 1725             


Arg Arg  Ala Thr Gln Trp Gly  Ser Phe Tyr Ser Pro  Ala Gln Thr 
    1730                 1735                 1740             


Ala Asn  Asn Pro Cys Ser Arg  Tyr Glu Asp Tyr Gly  Met Thr Pro 
    1745                 1750                 1755             


Pro Thr  Gly Pro Leu Pro Arg  Pro Gly Phe Gly Pro  Gly Leu Leu 
    1760                 1765                 1770             


Gln Ser  Thr Glu Leu Val Pro  Pro Asp Pro Gln Gln  Pro Gln Ala 
    1775                 1780                 1785             


Ser Ala  Glu Ala Pro Phe Ala  Ala Arg Gly Ile Tyr  Ser Glu Glu 
    1790                 1795                 1800             


Met Pro  Ser Val Ala Arg Pro  Arg Pro Val Gly Gly  Thr Thr Gly 
    1805                 1810                 1815             


Ser Gln  Ile Gln His Leu Thr  Gln Val Gly Ile Ala  Ser Arg Ile 
    1820                 1825                 1830             


Gly Ala  Gln Pro Val Glu Ile  Pro Pro Ser Arg Gly  Ser Gln Tyr 
    1835                 1840                 1845             


Gly Gly  Pro Gly Trp Pro Ser  Tyr Gly Glu Asp Glu  Ala Gly Arg 
    1850                 1855                 1860             


Arg Glu  Ala Thr His Met Leu  Gly His Gln Glu Tyr  Ser Ser Ser 
    1865                 1870                 1875             


Pro Leu  Phe Gln Val Pro Arg  Thr Ser Gly Arg Glu  Pro Ser Ala 
    1880                 1885                 1890             


Pro Ser  Gly Asn Leu Pro His  Arg Gly Leu Gln Gly  Pro Gly Leu 
    1895                 1900                 1905             


Gly Tyr  Pro Thr Ser Ser Thr  Glu Asp Leu Gln Pro  Gly His Ser 
    1910                 1915                 1920             


Ser Ala  Ser Leu Ile Lys Ala  Ile Arg Glu Glu Leu  Leu Arg Leu 
    1925                 1930                 1935             


Ser Gln  Lys Gln Ser Thr Val  Gln Asn Phe His Ser  
    1940                 1945                 1950 


<210>  57
<211>  1671
<212>  DNA
<213>  Homo sapiens

<400>  57
acagcttcct gccgcaggcg ggcgggaggg cgggcacgga gaggcgggcg ccgaggaggg       60

gcaggtaggg ctgggacgca ggggtaactg gatcccccga cttcagccca ggccctggtc      120

tgaccaccct gggagcaggg actttccaca gtcagctgga cgcacactca gcccagtaaa      180

agaggggacc catcccggga gccccgggga gggcacagct gcctcctccc gggctcccct      240

gccacctggt gcctacctgc cccctgctcc ctgccgggtc cggtcctcac cccatcttca      300

tctggccttg actctgccct tgaggggcct aggggtgcag ccagcctgct ccgagctccc      360

ctgcagatgg aggaggccat cctggtcccc tgcgtgctgg ggctcctgct gctgcccatc      420

ctggccatgt tgatggcact gtgtgtgcac tgccacagac tgccaggctc ctacgacagc      480

acatcctcag atagtttgta tccaaggggc atccagttca aacggcctca cacggttgcc      540

ccctggccac ctgcctaccc acctgtcacc tcctacccac ccctgagcca gccagacctg      600

ctccccatcc caagatcccc gcagcccctt gggggctccc accggacgcc atcttcccgg      660

cgggattctg atggtgccaa cagtgtggcg agctacgaga acgaggaacc agcctgtgag      720

gatgcggatg aggatgagga cgactatcac aacccaggct acctggtggt gcttcctgac      780

agcaccccgg ccactagcac tgctgcccca tcagctcctg cactcagcac ccctggcatc      840

cgagacagtg ccttctccat ggagtccatt gatgattacg tgaacgttcc ggagagcggg      900

gagagcgcag aagcgtctct ggatggcagc cgggagtatg tgaatgtgtc ccaggaactg      960

catcctggag cggctaagac tgagcctgcc gccctgagtt cccaggaggc agaggaagtg     1020

gaggaagagg gggctccaga ttacgagaat ctgcaggagc tgaactgagg gcctgtggag     1080

gccgagtctg tcctggaacc aggcttgcct gggacggctg agctgggcag ctggaagtgg     1140

ctctggggtc ctcacatggc gtcctgccct tgctccagcc tgacaacagc ctgagaaatc     1200

cccccgtaac ttattatcac tttggggttc ggcctgtgtc ccccgaacgc tctgcacctt     1260

ctgacgcagc ctgagaatga cctgccctgg ccccagccct actctgtgta atagaataaa     1320

ggcctgcgtg tgtctgtgtt gagcgtgcgt ctgtgtgtgc ctgtgtgcga gtctgagtca     1380

gagatttgga gatgtctctg tgtgtttgtg tgtatctgtg ggtctccatc ctccatgggg     1440

gctcagccag gtgctgtgac accccccttc tgaatgaagc cttctgacct gggctggcac     1500

tgctgggggt gaggacacat tgccccatga gacagtccca gaacacggca gctgctggct     1560

gtgacaatgg tttcaccatc cttagaccaa gggatgggac ctgatgacct gggaggactc     1620

tcttagttct taccttttgt ggttctcaat aaaacagaac ttaaaaaatt g              1671


<210>  58
<211>  1758
<212>  DNA
<213>  Homo sapiens

<400>  58
acagcttcct gccgcaggcg ggcgggaggg cgggcacgga gaggcgggcg ccgaggaggg       60

gcaggtaggg ctgggacgca ggggtaactg gatcccccga cttcagccca ggccctggtc      120

tgaccaccct gggagcaggg actttccaca gtcagctgga cgcacactca gcccagtaaa      180

agaggggacc catcccggga gccccgggga gggcacagct gcctcctccc gggctcccct      240

gccacctggt gcctacctgc cccctgctcc ctgccgggtc cggtcctcac cccatcttca      300

tctggccttg actctgccct tgaggggcct aggggtgcag ccagcctgct ccgagctccc      360

ctgcagatgg aggaggccat cctggtcccc tgcgtgctgg ggctcctgct gctgcccatc      420

ctggccatgt tgatggcact gtgtgtgcac tgccacagac tgccaggctc ctacgacagc      480

acatcctcag atagtttgta tccaaggggc atccagttca aacggcctca cacggttgcc      540

ccctggccac ctgcctaccc acctgtcacc tcctacccac ccctgagcca gccagacctg      600

ctccccatcc caagatcccc gcagcccctt gggggctccc accggacgcc atcttcccgg      660

cgggattctg atggtgccaa cagtgtggcg agctacgaga acgagggtgc gtctgggatc      720

cgaggtgccc aggctgggtg gggagtctgg ggtccgtcct ggactaggct gacccctgtg      780

tcgttacccc cagaaccagc ctgtgaggat gcggatgagg atgaggacga ctatcacaac      840

ccaggctacc tggtggtgct tcctgacagc accccggcca ctagcactgc tgccccatca      900

gctcctgcac tcagcacccc tggcatccga gacagtgcct tctccatgga gtccattgat      960

gattacgtga acgttccgga gagcggggag agcgcagaag cgtctctgga tggcagccgg     1020

gagtatgtga atgtgtccca ggaactgcat cctggagcgg ctaagactga gcctgccgcc     1080

ctgagttccc aggaggcaga ggaagtggag gaagaggggg ctccagatta cgagaatctg     1140

caggagctga actgagggcc tgtggaggcc gagtctgtcc tggaaccagg cttgcctggg     1200

acggctgagc tgggcagctg gaagtggctc tggggtcctc acatggcgtc ctgcccttgc     1260

tccagcctga caacagcctg agaaatcccc ccgtaactta ttatcacttt ggggttcggc     1320

ctgtgtcccc cgaacgctct gcaccttctg acgcagcctg agaatgacct gccctggccc     1380

cagccctact ctgtgtaata gaataaaggc ctgcgtgtgt ctgtgttgag cgtgcgtctg     1440

tgtgtgcctg tgtgcgagtc tgagtcagag atttggagat gtctctgtgt gtttgtgtgt     1500

atctgtgggt ctccatcctc catgggggct cagccaggtg ctgtgacacc ccccttctga     1560

atgaagcctt ctgacctggg ctggcactgc tgggggtgag gacacattgc cccatgagac     1620

agtcccagaa cacggcagct gctggctgtg acaatggttt caccatcctt agaccaaggg     1680

atgggacctg atgacctggg aggactctct tagttcttac cttttgtggt tctcaataaa     1740

acagaactta aaaaattg                                                   1758


<210>  59
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His 
        115                 120                 125             


Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser 
    130                 135                 140                 


Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp 
145                 150                 155                 160 


Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu 
                165                 170                 175     


Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
            180                 185                 190         


Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala 
        195                 200                 205             


Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro 
    210                 215                 220                 


Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230             


<210>  60
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp 
        115                 120                 125             


Gly Pro Ser Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro 
    130                 135                 140                 


Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly 
145                 150                 155                 160 


Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala 
                165                 170                 175     


Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe 
            180                 185                 190         


Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu 
        195                 200                 205             


Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser 
    210                 215                 220                 


Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser 
225                 230                 235                 240 


Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu 
                245                 250                 255     


Asn Leu Gln Glu Leu Asn 
            260         


<210>  61
<211>  2091
<212>  DNA
<213>  Homo sapiens

<400>  61
gagacaggtg gtggctacga cggcgaaggg agctgagact gtccaggcag ccaggttagg       60

ccaggaggac catgtgaatg gggccagagg gctcccgggc tgggcaggga ccatgggctg      120

tggctgcagc tcacacccgg aagatgactg gatggaaaac atcgatgtgt gtgagaactg      180

ccattatccc atagtcccac tggatggcaa gggcacgctg ctcatccgaa atggctctga      240

ggtgcgggac ccactggtta cctacgaagg ctccaatccg ccggcttccc cactgcaaga      300

caacctggtt atcgctctgc acagctatga gccctctcac gacggagatc tgggctttga      360

gaagggggaa cagctccgca tcctggagca gagcggcgag tggtggaagg cgcagtccct      420

gaccacgggc caggaaggct tcatcccctt caattttgtg gccaaagcga acagcctgga      480

gcccgaaccc tggttcttca agaacctgag ccgcaaggac gcggagcggc agctcctggc      540

gcccgggaac actcacggct ccttcctcat ccgggagagc gagagcaccg cgggatcgtt      600

ttcactgtcg gtccgggact tcgaccagaa ccagggagag gtggtgaaac attacaagat      660

ccgtaatctg gacaacggtg gcttctacat ctcccctcga atcacttttc ccggcctgca      720

tgaactggtc cgccattaca ccaatgcttc agatgggctg tgcacacggt tgagccgccc      780

ctgccagacc cagaagcccc agaagccgtg gtgggaggac gagtgggagg ttcccaggga      840

gacgctgaag ctggtggagc ggctgggggc tggacagttc ggggaggtgt ggatggggta      900

ctacaacggg cacacgaagg tggcggtgaa gagcctgaag cagggcagca tgtccccgga      960

cgccttcctg gccgaggcca acctcatgaa gcagctgcaa caccagcggc tggttcggct     1020

ctacgctgtg gtcacccagg agcccatcta catcatcact gaatacatgg agaatgggag     1080

tctagtggat tttctcaaga ccccttcagg catcaagttg accatcaaca aactcctgga     1140

catggcagcc caaattgcag aaggcatggc attcattgaa gagcggaatt atattcatcg     1200

tgaccttcgg gctgccaaca ttctggtgtc tgacaccctg agctgcaaga ttgcagactt     1260

tggcctagca cgcctcattg aggacaacga gtacacagcc agggaggggg ccaagtttcc     1320

cattaagtgg acagcgccag aagccattaa ctacgggaca ttcaccatca agtcagatgt     1380

gtggtctttt gggatcctgc tgacggaaat tgtcacccac ggccgcatcc cttacccagg     1440

gatgaccaac ccggaggtga ttcagaacct ggagcgaggc taccgcatgg tgcgccctga     1500

caactgtcca gaggagctgt accaactcat gaggctgtgc tggaaggagc gcccagagga     1560

ccggcccacc tttgactacc tgcgcagtgt gctggaggac ttcttcacgg ccacagaggg     1620

ccagtaccag cctcagcctt gagaggcctt gagaggccct ggggttctcc ccctttctct     1680

ccagcctgac ttggggagat ggagttcttg tgccatagtc acatggccta tgcacatatg     1740

gactctgcac atgaatccca cccacatgtg acacatatgc accttgtgtc tgtacacgtg     1800

tcctgtagtt gcgtggactc tgcacatgtc ttgtacatgt gtagcctgtg catgtatgtc     1860

ttggacactg tacaaggtac ccctttctgg ctctcccatt tcctgagacc acagagagag     1920

gggagaagcc tgggattgac agaagcttct gcccacctac ttttctttcc tcagatcatc     1980

cagaagttcc tcaagggcca ggactttatc taatacctct gtgtgctcct ccttggtgcc     2040

tggcctggca cacatcagga gttcaataaa tgtctgttga tgactgttgt a              2091


<210>  62
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  63
<211>  4438
<212>  DNA
<213>  Homo sapiens

<400>  63
ccgtgggacg ggcggaggcg cccgagtccc gcttccccgg cgcccttcca ccccgagccc       60

gactcagccc gcggccacct gcgccccgcc cctgtcggcc gcgcccgagc ccagcgccgc      120

gagccgctcc ccggcgggct ggctcctggc cccggaagcg cgagcgttca cttagcggcg      180

agtggctccg tctccgcgga cagagcgcgc gccccctggc ccggcccgcg aggggctccc      240

ggcgcggtcc ccgagcattt cccgccgggt ggagcgggcc gagcccggca ggatgaccag      300

ccccgcggcc gctcaaagcc gggagatcga ctgtttgagc ccggaagcgc agaagctggc      360

ggaagcccgg ctcgctgcaa aacgggcggc ccgcgcggag gctcgcgaga tccgcatgaa      420

ggagctggag cggcagcaga aggaggaaga cagtgagcgc tactctcgta gatccagaag      480

aaacacatcg gcttctgatg aagacgagcg catgtcagtg ggtagtcgtg gaagcctgag      540

ggtagaagag agaccagaaa aagattttac tgagaagggg tctcgtaaca tgccgggcct      600

gtctgcagcc acgctggcct ctctgggtgg gacttcctct cggagaggca gcggagacac      660

ctccatctcc atcgacaccg aggcatccat cagggaaatc aaggactctc tagcagaagt      720

tgaagagaaa tataagaagg ctatggtttc caatgctcag ctagacaatg aaaagacaaa      780

cttcatgtac caggttgata ccctaaaaga tatgttgctg gagcttgaag aacagctggc      840

tgaatctagg cggcagtacg aagagaaaaa caaagaattt gaaagggaaa aacacgccca      900

cagtatactg caatttcagt ttgctgaagt caaggaggcc ctgaagcaaa gagaggaaat      960

gctcgagaaa catggaataa tcctaaattc agaaatagct accaatggag agacttccga     1020

caccctcaat aatgttggat accaaggtcc taccaagatg acaaaagaag agttaaatgc     1080

cctcaagtcg acaggggatg ggaccctagg aagagccagt gaagtggagg tgaaaaatga     1140

aatcgtggcg aatgtgggga aaagagaaat cttgcacaat actgagaaag aacaacacac     1200

agaggacaca gtgaaggact gtgtggacat agaggtattc cctgctggtg agaataccga     1260

ggaccagaaa tcctctgaag acactgcccc attcctagga accttagcag gtgctaccta     1320

tgaggaacag gttcaaagcc aaattcttga gagcagttct ctccctgaaa acacagtaca     1380

ggttgagtca aatgaggtca tgggtgcacc agatgacagg accagaactc cccttgagcc     1440

atccaactgt tggagtgact tagatggtgg gaaccacaca gagaatgtgg gagaggcagc     1500

agtgactcag gttgaagagc aggcaggcac agtggcctcg tgtcctttag ggcatagtga     1560

tgacacagtt tatcatgatg acaaatgtat ggtagaggtc ccccaagagt tagagacaag     1620

cacagggcat agtttagaga aagaattcac caaccaggaa gcagctgagc ccaaggaggt     1680

tccagcgcac agtacagaag taggtaggga tcacaacgaa gaagagggtg aagaaacagg     1740

attaagggac gagaaaccaa tcaagacaga agttcctggt tctccagcag gaactgaggg     1800

caactgtcag gaagcgacag gtccaagtac agtagacact caaaatgaac ccttagatat     1860

gaaagagccc gatgaagaaa agagtgacca acagggagag gcattggact catcgcagaa     1920

gaagacaaag aacaagaaaa agaaaaacaa gaagaaaaaa tccccagtac ccgtagaaac     1980

ccttaaagat gttaaaaaag agttaacgta tcagaacaca gatttaagtg aaattaagga     2040

agaagagcag gtaaagtcta ctgacagaaa gtcagcagtg gaagcccaaa acgaggtgac     2100

tgaaaatcca aaacagaaaa ttgcagcaga aagcagtgaa aatgttgatt gtccggagaa     2160

tcctaaaatt aagttggatg gaaaacttga ccaagaaggt gatgatgtac aaacagcagc     2220

tgaggaggta ctagctgatg gagacacatt agattttgag gatgacaccg ttcaatcatc     2280

aggcccgagg gctggtggtg aagaattaga tgaaggtgtt gcaaaagata atgctaaaat     2340

agatggtgcc actcaaagca gtcctgcaga accaaagagc gaagacgcag atcgctgcac     2400

cctgcccgaa catgaaagtc cctcacagga cattagtgat gcctgtgaag cagaaagtac     2460

agagaggtgt gagatgtcag aacatccaag tcagaccgtc aggaaagctt tagacagcaa     2520

tagcctagag aacgatgact tgtcggcacc aggaagagag ccagggcact tcaatccaga     2580

aagcagagaa gataccagag gagggaatga gaagggcaaa agcaaagaag actgtaccat     2640

gtcctaagct gaggcaggcg gcaggcgcgg tgcacaggaa gtctcagtgt gaaggggtct     2700

tttctctcca ctgccaatgt aagtagaatg ttctaaattc atagagaggc actgtatgac     2760

aattaccagg tgctctactg ctttaagtta tagactgtta cttgtagatt tccatgtaat     2820

cattgaggtt atcacccaga ttagaaagac atatttgtta tcagtgtacg ttctaattga     2880

gagcattcca gtagtatcaa acaataatgt ctactgttta tagtccactt aataaaaata     2940

gaggcattta ctatttgcct taggctgata ggaatgtggg ttttcttgac caaatatatc     3000

agcatctaat tgaaatgacc aaatagcatt cttagacttc tgtattatga atataattga     3060

tatttaaatt aatgtcttgt tcacatatgt gtactttcat atttgatttt aaaatgtaca     3120

ttataacctg tatggtattt tatttaaagg agataaacag ccaaatagca aataggtcac     3180

tgaatgataa gatttgcacc ttagaacaat aatcatttta aggataacaa gtaaatgtct     3240

gaaagcatga ggggctttat ttgcctttac ctcatatgag tctttgatct tgaaccgata     3300

cttttggatc tcattgttga tatacctgaa tttactttgt aagagatttt aacttcactt     3360

catgctgatg atgtatcaaa ttcattttat agaaagattt aaagtttttt tctggaagtg     3420

atatatgtca aattacattt cctactgcag tatttgagca gggacagtca ttttttaaat     3480

gtttttggcc gggcgtggtg gctcatgcct gtaatctcag tacattggga ggccaaggca     3540

ggtggatcac ctgaggtcaa gagttcgagg ccagcctggc caacatggtg aaaccctgtc     3600

tctactaaaa atacaaaaaa ttggccgggc gtgatggtgg gcgcctgtaa tcccagccac     3660

tccagaggct gaggcaggag aatcgcttga acctgcgagg cagagattgc agtgagccaa     3720

gatcaagcca ttgtactcca gcctggacaa caagagcgaa actctgtcta aaaaaaaaaa     3780

aaaaaacaca cacacacaca acacaatgtt ttcacgcctg taaacctagc acattgggaa     3840

gccaaggtgg gaggattgct tgaggccagg agttcaaggc tgcagtgagc tatgattgca     3900

cactgtactc tagcctggga gacagagtga gacactgtct ctaaaaaaaa aaaaaaaaaa     3960

aaaaaaagtt tttgaacctt aaaatacttt gtttgaattt ctaatcatca ttcaaaagag     4020

cagtaaaaaa tggttacttg ttcttgtaca agctactaat tagactatag taggatattt     4080

taaagagctg aatcactttt ggtattttgg tataaatatt ttcatttgtt atgtcccagt     4140

atattcttac tggaaaattc ttgttttgat ctgcctgaag aaaatatctg ttttctatat     4200

aaaaaaattt tttaaaataa ttgtaaagtt agatttaaaa ttgtaaaata taaaatcaca     4260

aaggaatgta ccttatgaat gttgttgaca ttttatgaaa ttatgtggat tcatattact     4320

gttacaagat agaattgaat gcaaaaagac caaaacctca ataaaatttg aggaaaacgt     4380

gttattatgt aattgaaata aaaacatttt ataattgtgc aaaaaaaaaa aaaaaaaa       4438


<210>  64
<211>  4109
<212>  DNA
<213>  Homo sapiens

<400>  64
cgggccgggg cggcgcgagc ggctggagca acgggccccg cggcagctgc gggcgacgcg       60

gtcgatggac atgggcaccc agggatcggg gcgcaagcgg ctccccaacc gggagcggct      120

cacggcggag gacgacgcgc tcaaccagat cgcgcgggag gcggaagccc ggctcgctgc      180

aaaacgggcg gcccgcgcgg aggctcgcga gatccgcatg aaggagctgg agcggcagca      240

gaaggagatc tatcaggtcc aaaagaaata ttatgggctg gatacaaaat ggggtgacat      300

cgagcagtgg atggaagaca gtgagcgcta ctctcgtaga tccagaagaa acacatcggc      360

ttctgatgaa gacgagcgca tgtcagtggg tagtcgtgga agcctgaggt cgcagcctga      420

cttggagtat gggggtcctt acgcctggac aaatggttat gatggagaat tgtatggatc      480

acagtccctg aatagaagat ctggcaggcc ctcctgtctg tacagcgctg cccggccttc      540

ggggagttac cgggcgtctg tgttggatga aggcagcttc ggtgggaccc gacggggcag      600

cacctccggc tcccgtgctc cctcggagta cagcggccac ctcaactcca gctcccgcgc      660

ctcctccagg gccagctcgg cccgggccag ccctgtggta gaagagagac cagaaaaaga      720

ttttactgag aaggggtctc gtaacatgcc gggcctgtct gcagccacgc tggcctctct      780

gggtgggact tcctctcgga gaggcagcgg agacacctcc atctccatcg acaccgaggc      840

atccatcagg gaaatcaagg aactcaatga gttaaaggac cagattcagg atgtagaagg      900

caaatacatg cagggattga aagagatgaa ggactctcta gcagaagttg aagagaaata      960

taagaaggct atggtttcca atgctcagct agacaatgaa aagacaaact tcatgtacca     1020

ggttgatacc ctaaaagata tgttgctgga gcttgaagaa cagctggctg aatctaggcg     1080

gcagtacgaa gagaaaaaca aagaatttga aagggaaaaa cacgcccaca gtatactgca     1140

atttcagttt gctgaagtca aggaggccct gaagcaaaga gaggaaatgc tcgaggaaat     1200

ccgacagcta cagcagaaac aggcgagttc tatcagggag atttctgatc ttcaggaaac     1260

aatagagtgg aaagacaaaa agataggggc attagagagg cagaaagagt tctttgattc     1320

cgtaaggagt gaacgggatg atcttagaga agaagtagtc atgctgaaag aggaattaaa     1380

gaaacatgga ataatcctaa attcagaaat agctaccaat ggagagactt ccgacaccct     1440

caataatgtt ggataccaag gtcctaccaa gatgacaaaa gaagagttaa atgccctcaa     1500

gtcgacaggg gatgggaccc tagatattag gttgaaaaag ctggttgatg aacgggaatg     1560

cttattggaa cagattaaga aactcaaagg gcagctggag gagagacaga agattggcaa     1620

actagacaat cttcgatctg aagatgatgt cttggaaaac gggacagaca tgcatgtaat     1680

ggacctacaa agggatgcca acagacagat cagcgacctc aaatttaaac ttgcaaaatc     1740

tgagcaagag ataactgcat tagaacaaaa tgtaataagg ttagagagtc aagtatcacg     1800

ttacaaatca gcggctgaaa atgcagaaaa aatagaagat gaacttaagg cagaaaaacg     1860

gaaactccaa agagagctcc gctctgcatt ggataaaaca gaagagctcg aggtgagcaa     1920

cggccactta gtgaagcgtc tggaaaaaat gaaagcaaat cggagtgcac tcttgtccca     1980

gcagtaaatt ccagctctga tcaggcaact ggttggtgac tggagagcat tgtttcatag     2040

gcttttctct gtcctatctg ggagcgctgc ttcttcccct gccttccgag agacgaagac     2100

cgtggcgagc ttggcgctta ggggctcccg tgccatggct caccccaggg agccccagca     2160

gccaccaggt gcctctgtct gcagacccct ggcccgggct ggcgccgacg ctcagaacct     2220

gcaggtactt cataagcaca caggggcctc gagggagctc tgtgtctgac cgcacagcag     2280

cctctgaatg ccgctggaag tgatgatcaa agtaaagatt cagttgggac ttgagttttt     2340

tttttttttc atgtgtcttg ctgaagatta aggggaaatg ttacagtgtt gggacttcct     2400

ttcatggcag aatctacaat ttgagcgact tcagtagtat ctcttagtct acgcttttca     2460

tacacaaaac actgtggaac cacaagccat taccaagcaa aactctttca ctggaaacaa     2520

gggggcagtc tagaagtaaa agtgacctta agaagactct ttacaggcaa caaatgaagc     2580

ttttctaagg gatttttgca tcagttcagt cataagaata cttttttcca gggtaattag     2640

gcaatagctt cactgaaaat gacagctttt cattgcatta tttaatcctt atatttggaa     2700

ttgaagtcgt taacttcttt taaagaatgt actattagaa aaattaaaaa tgaaatgttg     2760

agagacttca gcaatgtggt tctaattttt ttccactgag aaagaagatc tttaatttca     2820

tattaatggt tctgtatatt ttgggtcatc tttttatttt ttaagaatat caagtcaatt     2880

catttttctt tccctattta aaaaaaaagg tgttttcaca gaatgagtgc acttaaaaag     2940

tgaagtgaag gaggaggtaa cagtagagac gatggcaata tcatcaagga caaaagtaaa     3000

aacgtttagc tacctgctga tttttagtga ctgttcatat atgttgtatt tcaagtatgg     3060

ctggtgaagc cagtcagctt ttcgggacgt tagcaagtgg aaactgagtc agtatcatcc     3120

aaaaccatat ctagtcttaa cacatggaga atgctggagt gagggttgtg agttcagggt     3180

atataatcaa gaaaacactc ccagcataat gctaggggtc accagtgtcc atcccccaga     3240

actgtatgga tctaggatat acacagctgc gttgcattaa gaaagagatg aaatctctat     3300

taaaatacac aagatttttg tatctccttg tgcagaggat atttgccact gcccattggg     3360

aagcagacaa gttatagggg gctgggggcc aacactggca agtaggaaac cacgggtcgg     3420

acaggtgagc aaaatgtgct ggcaggtggg caccactggg agacccacac tgcacacccg     3480

ggcaccgtat gaacaggaaa gaggaaggaa gctggacgaa gcccctcagg gaccctgtgc     3540

tgaccatgct gggcccaccg gcaaaaggga gatattcagt tccttgtctc atccttaagg     3600

tttcttccac aacatctgaa tacaagcatg tttaactggg aaaatgtcta tgtcatgcgt     3660

gaataacacc agcagcaaac actcacacat cacgcagaca cggccggcag catgctgacg     3720

cttttaggta tttttcactc atgcaatttt cacatatttt cactcatttc atttgcacgg     3780

aaattctatg aggtagatgc tgttatcaaa tccacattac agatgaggga cccagggtcc     3840

aggaaggtga actggcagaa gtctcccagc tggtagaaca gggctgcaag gcatcgattc     3900

ccaggtgtct cacagccctg agaagatggc gttttcccta tcagtggctc tgaggaagtc     3960

aagccttcag tctctacctc tcccaccaat tcttttggaa acagcaaacc aatgttacac     4020

acacttccta atccagagga agctagaaca cgatttttaa atttatttag taaaataaaa     4080

ctttttttgc agatgtaacg aaaaaaaaa                                       4109


<210>  65
<211>  4285
<212>  DNA
<213>  Homo sapiens

<400>  65
gcccttccac cccgagcccg actcagcccg cggccacctg cgccccgccc ctgtcggccg       60

cgcccgagcc cagcgccgcg agccgctccc cggcgggctg gctcctggcc ccggaagcgc      120

gagcgttcac ttagcggcga gtggctccgt ctccgcggac agagcgcgcg ccccctggcc      180

cggcccgcga ggggctcccg gcgcggtccc cgagcatttc ccgccgggtg gagcgggccg      240

agcccggcag gatgaccagc cccgcggccg ctcaaagccg ggagatcgac tgtttgagcc      300

cggaagcgca gaagctggcg gaagcccggc tcgctgcaaa acgggcggcc cgcgcggagg      360

ctcgcgagat ccgcatgaag gagctggagc ggcagcagaa ggaggtagaa gagagaccag      420

aaaaagattt tactgagaag gggtctcgta acatgccggg cctgtctgca gccacgctgg      480

cctctctggg tgggacttcc tctcggagag gcagcggaga cacctccatc tccatcgaca      540

ccgaggcatc catcagggaa atcaaggact ctctagcaga agttgaagag aaatataaga      600

aggctatggt ttccaatgct cagctagaca atgaaaagac aaacttcatg taccaggttg      660

ataccctaaa agatatgttg ctggagcttg aagaacagct ggctgaatct aggcggcagt      720

acgaagagaa aaacaaagaa tttgaaaggg aaaaacacgc ccacagtata ctgcaatttc      780

agtttgctga agtcaaggag gccctgaagc aaagagagga aatgctcgag aaacatggaa      840

taatcctaaa ttcagaaata gctaccaatg gagagacttc cgacaccctc aataatgttg      900

gataccaagg tcctaccaag atgacaaaag aagagttaaa tgccctcaag tcgacagggg      960

atgggaccct aggaagagcc agtgaagtgg aggtgaaaaa tgaaatcgtg gcgaatgtgg     1020

ggaaaagaga aatcttgcac aatactgaga aagaacaaca cacagaggac acagtgaagg     1080

actgtgtgga catagaggta ttccctgctg gtgagaatac cgaggaccag aaatcctctg     1140

aagacactgc cccattccta ggaaccttag caggtgctac ctatgaggaa caggttcaaa     1200

gccaaattct tgagagcagt tctctccctg aaaacacagt acaggttgag tcaaatgagg     1260

tcatgggtgc accagatgac aggaccagaa ctccccttga gccatccaac tgttggagtg     1320

acttagatgg tgggaaccac acagagaatg tgggagaggc agcagtgact caggttgaag     1380

agcaggcagg cacagtggcc tcgtgtcctt tagggcatag tgatgacaca gtttatcatg     1440

atgacaaatg tatggtagag gtcccccaag agttagagac aagcacaggg catagtttag     1500

agaaagaatt caccaaccag gaagcagctg agcccaagga ggttccagcg cacagtacag     1560

aagtaggtag ggatcacaac gaagaagagg gtgaagaaac aggattaagg gacgagaaac     1620

caatcaagac agaagttcct ggttctccag caggaactga gggcaactgt caggaagcga     1680

caggtccaag tacagtagac actcaaaatg aacccttaga tatgaaagag cccgatgaag     1740

aaaagagtga ccaacaggga gaggcattgg actcatcgca gaagaagaca aagaacaaga     1800

aaaagaaaaa caagaagaaa aaatccccag tacccgtaga aacccttaaa gatgttaaaa     1860

aagagttaac gtatcagaac acagatttaa gtgaaattaa ggaagaagag caggtaaagt     1920

ctactgacag aaagtcagca gtggaagccc aaaacgaggt gactgaaaat ccaaaacaga     1980

aaattgcagc agaaagcagt gaaaatgttg attgtccgga gaatcctaaa attaagttgg     2040

atggaaaact tgaccaagaa ggtgatgatg tacaaacagc agctgaggag gtactagctg     2100

atggagacac attagatttt gaggatgaca ccgttcaatc atcaggcccg agggctggtg     2160

gtgaagaatt agatgaaggt gttgcaaaag ataatgctaa aatagatggt gccactcaaa     2220

gcagtcctgc agaaccaaag agcgaagacg cagatcgctg caccctgccc gaacatgaaa     2280

gtccctcaca ggacattagt gatgcctgtg aagcagaaag tacagagagg tgtgagatgt     2340

cagaacatcc aagtcagacc gtcaggaaag ctttagacag caatagccta gagaacgatg     2400

acttgtcggc accaggaaga gagccagggc acttcaatcc agaaagcaga gaagatacca     2460

gaggagggaa tgagaagggc aaaagcaaag aagactgtac catgtcctaa gctgaggcag     2520

gcggcaggcg cggtgcacag gaagtctcag tgtgaagggg tcttttctct ccactgccaa     2580

tgtaagtaga atgttctaaa ttcatagaga ggcactgtat gacaattacc aggtgctcta     2640

ctgctttaag ttatagactg ttacttgtag atttccatgt aatcattgag gttatcaccc     2700

agattagaaa gacatatttg ttatcagtgt acgttctaat tgagagcatt ccagtagtat     2760

caaacaataa tgtctactgt ttatagtcca cttaataaaa atagaggcat ttactatttg     2820

ccttaggctg ataggaatgt gggttttctt gaccaaatat atcagcatct aattgaaatg     2880

accaaatagc attcttagac ttctgtatta tgaatataat tgatatttaa attaatgtct     2940

tgttcacata tgtgtacttt catatttgat tttaaaatgt acattataac ctgtatggta     3000

ttttatttaa aggagataaa cagccaaata gcaaataggt cactgaatga taagatttgc     3060

accttagaac aataatcatt ttaaggataa caagtaaatg tctgaaagca tgaggggctt     3120

tatttgcctt tacctcatat gagtctttga tcttgaaccg atacttttgg atctcattgt     3180

tgatatacct gaatttactt tgtaagagat tttaacttca cttcatgctg atgatgtatc     3240

aaattcattt tatagaaaga tttaaagttt ttttctggaa gtgatatatg tcaaattaca     3300

tttcctactg cagtatttga gcagggacag tcatttttta aatgtttttg gccgggcgtg     3360

gtggctcatg cctgtaatct cagtacattg ggaggccaag gcaggtggat cacctgaggt     3420

caagagttcg aggccagcct ggccaacatg gtgaaaccct gtctctacta aaaatacaaa     3480

aaattggccg ggcgtgatgg tgggcgcctg taatcccagc cactccagag gctgaggcag     3540

gagaatcgct tgaacctgcg aggcagagat tgcagtgagc caagatcaag ccattgtact     3600

ccagcctgga caacaagagc gaaactctgt ctaaaaaaaa aaaaaaaaac acacacacac     3660

acaacacaat gttttcacgc ctgtaaacct agcacattgg gaagccaagg tgggaggatt     3720

gcttgaggcc aggagttcaa ggctgcagtg agctatgatt gcacactgta ctctagcctg     3780

ggagacagag tgagacactg tctctaaaaa aaaaaaaaaa aaaaaaaaaa gtttttgaac     3840

cttaaaatac tttgtttgaa tttctaatca tcattcaaaa gagcagtaaa aaatggttac     3900

ttgttcttgt acaagctact aattagacta tagtaggata ttttaaagag ctgaatcact     3960

tttggtattt tggtataaat attttcattt gttatgtccc agtatattct tactggaaaa     4020

ttcttgtttt gatctgcctg aagaaaatat ctgttttcta tataaaaaaa ttttttaaaa     4080

taattgtaaa gttagattta aaattgtaaa atataaaatc acaaaggaat gtaccttatg     4140

aatgttgttg acattttatg aaattatgtg gattcatatt actgttacaa gatagaattg     4200

aatgcaaaaa gaccaaaacc tcaataaaat ttgaggaaaa cgtgttatta tgtaattgaa     4260

ataaaaacat tttataattg tgcaa                                           4285


<210>  66
<211>  4453
<212>  DNA
<213>  Homo sapiens

<400>  66
gcccttccac cccgagcccg actcagcccg cggccacctg cgccccgccc ctgtcggccg       60

cgcccgagcc cagcgccgcg agccgctccc cggcgggctg gctcctggcc ccggaagcgc      120

gagcgttcac ttagcggcga gtggctccgt ctccgcggac agagcgcgcg ccccctggcc      180

cggcccgcga ggggctcccg gcgcggtccc cgagcatttc ccgccgggtg gagcgggccg      240

agcccggcag gatgaccagc cccgcggccg ctcaaagccg ggagatcgac tgtttgagcc      300

cggaagcgca gaagctggcg gaagcccggc tcgctgcaaa acgggcggcc cgcgcggagg      360

ctcgcgagat ccgcatgaag gagctggagc ggcagcagaa ggaggaagac agtgagcgct      420

actctcgtag atccagaaga aacacatcgg cttctgatga agacgagcgc atgtcagtgg      480

gtagtcgtgg aagcctgagg gtagaagaga gaccagaaaa agattttact gagaaggggt      540

ctcgtaacat gccgggcctg tctgcagcca cgctggcctc tctgggtggg acttcctctc      600

ggagaggcag cggagacacc tccatctcca tcgacaccga ggcatccatc agggaaatca      660

aggaactcaa tgagttaaag gaccagattc aggatgtaga aggcaaatac atgcagggat      720

tgaaagagat gaaggactct ctagcagaag ttgaagagaa atataagaag gctatggttt      780

ccaatgctca gctagacaat gaaaagacaa acttcatgta ccaggttgat accctaaaag      840

atatgttgct ggagcttgaa gaacagctgg ctgaatctag gcggcagtac gaagagaaaa      900

acaaagaatt tgaaagggaa aaacacgccc acagtatact gcaatttcag tttgctgaag      960

tcaaggaggc cctgaagcaa agagaggaaa tgctcgagaa acatggaata atcctaaatt     1020

cagaaatagc taccaatgga gagacttccg acaccctcaa taatgttgga taccaaggtc     1080

ctaccaagat gacaaaagaa gagttaaatg ccctcaagtc gacaggggat gggaccctag     1140

gaagagccag tgaagtggag gtgaaaaatg aaatcgtggc gaatgtgggg aaaagagaaa     1200

tcttgcacaa tactgagaaa gaacaacaca cagaggacac agtgaaggac tgtgtggaca     1260

tagaggtatt ccctgctggt gagaataccg aggaccagaa atcctctgaa gacactgccc     1320

cattcctagg aaccttagca ggtgctacct atgaggaaca ggttcaaagc caaattcttg     1380

agagcagttc tctccctgaa aacacagtac aggttgagtc aaatgaggtc atgggtgcac     1440

cagatgacag gaccagaact ccccttgagc catccaactg ttggagtgac ttagatggtg     1500

ggaaccacac agagaatgtg ggagaggcag cagtgactca ggttgaagag caggcaggca     1560

cagtggcctc gtgtccttta gggcatagtg atgacacagt ttatcatgat gacaaatgta     1620

tggtagaggt cccccaagag ttagagacaa gcacagggca tagtttagag aaagaattca     1680

ccaaccagga agcagctgag cccaaggagg ttccagcgca cagtacagaa gtaggtaggg     1740

atcacaacga agaagagggt gaagaaacag gattaaggga cgagaaacca atcaagacag     1800

aagttcctgg ttctccagca ggaactgagg gcaactgtca ggaagcgaca ggtccaagta     1860

cagtagacac tcaaaatgaa cccttagata tgaaagagcc cgatgaagaa aagagtgacc     1920

aacagggaga ggcattggac tcatcgcaga agaagacaaa gaacaagaaa aagaaaaaca     1980

agaagaaaaa atccccagta cccgtagaaa cccttaaaga tgttaaaaaa gagttaacgt     2040

atcagaacac agatttaagt gaaattaagg aagaagagca ggtaaagtct actgacagaa     2100

agtcagcagt ggaagcccaa aacgaggtga ctgaaaatcc aaaacagaaa attgcagcag     2160

aaagcagtga aaatgttgat tgtccggaga atcctaaaat taagttggat ggaaaacttg     2220

accaagaagg tgatgatgta caaacagcag ctgaggaggt actagctgat ggagacacat     2280

tagattttga ggatgacacc gttcaatcat caggcccgag ggctggtggt gaagaattag     2340

atgaaggtgt tgcaaaagat aatgctaaaa tagatggtgc cactcaaagc agtcctgcag     2400

aaccaaagag cgaagacgca gatcgctgca ccctgcccga acatgaaagt ccctcacagg     2460

acattagtga tgcctgtgaa gcagaaagta cagagaggtg tgagatgtca gaacatccaa     2520

gtcagaccgt caggaaagct ttagacagca atagcctaga gaacgatgac ttgtcggcac     2580

caggaagaga gccagggcac ttcaatccag aaagcagaga agataccaga ggagggaatg     2640

agaagggcaa aagcaaagaa gactgtacca tgtcctaagc tgaggcaggc ggcaggcgcg     2700

gtgcacagga agtctcagtg tgaaggggtc ttttctctcc actgccaatg taagtagaat     2760

gttctaaatt catagagagg cactgtatga caattaccag gtgctctact gctttaagtt     2820

atagactgtt acttgtagat ttccatgtaa tcattgaggt tatcacccag attagaaaga     2880

catatttgtt atcagtgtac gttctaattg agagcattcc agtagtatca aacaataatg     2940

tctactgttt atagtccact taataaaaat agaggcattt actatttgcc ttaggctgat     3000

aggaatgtgg gttttcttga ccaaatatat cagcatctaa ttgaaatgac caaatagcat     3060

tcttagactt ctgtattatg aatataattg atatttaaat taatgtcttg ttcacatatg     3120

tgtactttca tatttgattt taaaatgtac attataacct gtatggtatt ttatttaaag     3180

gagataaaca gccaaatagc aaataggtca ctgaatgata agatttgcac cttagaacaa     3240

taatcatttt aaggataaca agtaaatgtc tgaaagcatg aggggcttta tttgccttta     3300

cctcatatga gtctttgatc ttgaaccgat acttttggat ctcattgttg atatacctga     3360

atttactttg taagagattt taacttcact tcatgctgat gatgtatcaa attcatttta     3420

tagaaagatt taaagttttt ttctggaagt gatatatgtc aaattacatt tcctactgca     3480

gtatttgagc agggacagtc attttttaaa tgtttttggc cgggcgtggt ggctcatgcc     3540

tgtaatctca gtacattggg aggccaaggc aggtggatca cctgaggtca agagttcgag     3600

gccagcctgg ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa attggccggg     3660

cgtgatggtg ggcgcctgta atcccagcca ctccagaggc tgaggcagga gaatcgcttg     3720

aacctgcgag gcagagattg cagtgagcca agatcaagcc attgtactcc agcctggaca     3780

acaagagcga aactctgtct aaaaaaaaaa aaaaaaacac acacacacac aacacaatgt     3840

tttcacgcct gtaaacctag cacattggga agccaaggtg ggaggattgc ttgaggccag     3900

gagttcaagg ctgcagtgag ctatgattgc acactgtact ctagcctggg agacagagtg     3960

agacactgtc tctaaaaaaa aaaaaaaaaa aaaaaaaagt ttttgaacct taaaatactt     4020

tgtttgaatt tctaatcatc attcaaaaga gcagtaaaaa atggttactt gttcttgtac     4080

aagctactaa ttagactata gtaggatatt ttaaagagct gaatcacttt tggtattttg     4140

gtataaatat tttcatttgt tatgtcccag tatattctta ctggaaaatt cttgttttga     4200

tctgcctgaa gaaaatatct gttttctata taaaaaaatt ttttaaaata attgtaaagt     4260

tagatttaaa attgtaaaat ataaaatcac aaaggaatgt accttatgaa tgttgttgac     4320

attttatgaa attatgtgga ttcatattac tgttacaaga tagaattgaa tgcaaaaaga     4380

ccaaaacctc aataaaattt gaggaaaacg tgttattatg taattgaaat aaaaacattt     4440

tataattgtg caa                                                        4453


<210>  67
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Thr Ser Pro Ala Ala Ala Gln Ser Arg Glu Ile Asp Cys Leu Ser 
1               5                   10                  15      


Pro Glu Ala Gln Lys Leu Ala Glu Ala Arg Leu Ala Ala Lys Arg Ala 
            20                  25                  30          


Ala Arg Ala Glu Ala Arg Glu Ile Arg Met Lys Glu Leu Glu Arg Gln 
        35                  40                  45              


Gln Lys Glu Glu Asp Ser Glu Arg Tyr Ser Arg Arg Ser Arg Arg Asn 
    50                  55                  60                  


Thr Ser Ala Ser Asp Glu Asp Glu Arg Met Ser Val Gly Ser Arg Gly 
65                  70                  75                  80  


Ser Leu Arg Val Glu Glu Arg Pro Glu Lys Asp Phe Thr Glu Lys Gly 
                85                  90                  95      


Ser Arg Asn Met Pro Gly Leu Ser Ala Ala Thr Leu Ala Ser Leu Gly 
            100                 105                 110         


Gly Thr Ser Ser Arg Arg Gly Ser Gly Asp Thr Ser Ile Ser Ile Asp 
        115                 120                 125             


Thr Glu Ala Ser Ile Arg Glu Ile Lys Asp Ser Leu Ala Glu Val Glu 
    130                 135                 140                 


Glu Lys Tyr Lys Lys Ala Met Val Ser Asn Ala Gln Leu Asp Asn Glu 
145                 150                 155                 160 


Lys Thr Asn Phe Met Tyr Gln Val Asp Thr Leu Lys Asp Met Leu Leu 
                165                 170                 175     


Glu Leu Glu Glu Gln Leu Ala Glu Ser Arg Arg Gln Tyr Glu Glu Lys 
            180                 185                 190         


Asn Lys Glu Phe Glu Arg Glu Lys His Ala His Ser Ile Leu Gln Phe 
        195                 200                 205             


Gln Phe Ala Glu Val Lys Glu Ala Leu Lys Gln Arg Glu Glu Met Leu 
    210                 215                 220                 


Glu Lys His Gly Ile Ile Leu Asn Ser Glu Ile Ala Thr Asn Gly Glu 
225                 230                 235                 240 


Thr Ser Asp Thr Leu Asn Asn Val Gly Tyr Gln Gly Pro Thr Lys Met 
                245                 250                 255     


Thr Lys Glu Glu Leu Asn Ala Leu Lys Ser Thr Gly Asp Gly Thr Leu 
            260                 265                 270         


Gly Arg Ala Ser Glu Val Glu Val Lys Asn Glu Ile Val Ala Asn Val 
        275                 280                 285             


Gly Lys Arg Glu Ile Leu His Asn Thr Glu Lys Glu Gln His Thr Glu 
    290                 295                 300                 


Asp Thr Val Lys Asp Cys Val Asp Ile Glu Val Phe Pro Ala Gly Glu 
305                 310                 315                 320 


Asn Thr Glu Asp Gln Lys Ser Ser Glu Asp Thr Ala Pro Phe Leu Gly 
                325                 330                 335     


Thr Leu Ala Gly Ala Thr Tyr Glu Glu Gln Val Gln Ser Gln Ile Leu 
            340                 345                 350         


Glu Ser Ser Ser Leu Pro Glu Asn Thr Val Gln Val Glu Ser Asn Glu 
        355                 360                 365             


Val Met Gly Ala Pro Asp Asp Arg Thr Arg Thr Pro Leu Glu Pro Ser 
    370                 375                 380                 


Asn Cys Trp Ser Asp Leu Asp Gly Gly Asn His Thr Glu Asn Val Gly 
385                 390                 395                 400 


Glu Ala Ala Val Thr Gln Val Glu Glu Gln Ala Gly Thr Val Ala Ser 
                405                 410                 415     


Cys Pro Leu Gly His Ser Asp Asp Thr Val Tyr His Asp Asp Lys Cys 
            420                 425                 430         


Met Val Glu Val Pro Gln Glu Leu Glu Thr Ser Thr Gly His Ser Leu 
        435                 440                 445             


Glu Lys Glu Phe Thr Asn Gln Glu Ala Ala Glu Pro Lys Glu Val Pro 
    450                 455                 460                 


Ala His Ser Thr Glu Val Gly Arg Asp His Asn Glu Glu Glu Gly Glu 
465                 470                 475                 480 


Glu Thr Gly Leu Arg Asp Glu Lys Pro Ile Lys Thr Glu Val Pro Gly 
                485                 490                 495     


Ser Pro Ala Gly Thr Glu Gly Asn Cys Gln Glu Ala Thr Gly Pro Ser 
            500                 505                 510         


Thr Val Asp Thr Gln Asn Glu Pro Leu Asp Met Lys Glu Pro Asp Glu 
        515                 520                 525             


Glu Lys Ser Asp Gln Gln Gly Glu Ala Leu Asp Ser Ser Gln Lys Lys 
    530                 535                 540                 


Thr Lys Asn Lys Lys Lys Lys Asn Lys Lys Lys Lys Ser Pro Val Pro 
545                 550                 555                 560 


Val Glu Thr Leu Lys Asp Val Lys Lys Glu Leu Thr Tyr Gln Asn Thr 
                565                 570                 575     


Asp Leu Ser Glu Ile Lys Glu Glu Glu Gln Val Lys Ser Thr Asp Arg 
            580                 585                 590         


Lys Ser Ala Val Glu Ala Gln Asn Glu Val Thr Glu Asn Pro Lys Gln 
        595                 600                 605             


Lys Ile Ala Ala Glu Ser Ser Glu Asn Val Asp Cys Pro Glu Asn Pro 
    610                 615                 620                 


Lys Ile Lys Leu Asp Gly Lys Leu Asp Gln Glu Gly Asp Asp Val Gln 
625                 630                 635                 640 


Thr Ala Ala Glu Glu Val Leu Ala Asp Gly Asp Thr Leu Asp Phe Glu 
                645                 650                 655     


Asp Asp Thr Val Gln Ser Ser Gly Pro Arg Ala Gly Gly Glu Glu Leu 
            660                 665                 670         


Asp Glu Gly Val Ala Lys Asp Asn Ala Lys Ile Asp Gly Ala Thr Gln 
        675                 680                 685             


Ser Ser Pro Ala Glu Pro Lys Ser Glu Asp Ala Asp Arg Cys Thr Leu 
    690                 695                 700                 


Pro Glu His Glu Ser Pro Ser Gln Asp Ile Ser Asp Ala Cys Glu Ala 
705                 710                 715                 720 


Glu Ser Thr Glu Arg Cys Glu Met Ser Glu His Pro Ser Gln Thr Val 
                725                 730                 735     


Arg Lys Ala Leu Asp Ser Asn Ser Leu Glu Asn Asp Asp Leu Ser Ala 
            740                 745                 750         


Pro Gly Arg Glu Pro Gly His Phe Asn Pro Glu Ser Arg Glu Asp Thr 
        755                 760                 765             


Arg Gly Gly Asn Glu Lys Gly Lys Ser Lys Glu Asp Cys Thr Met Ser 
    770                 775                 780                 


<210>  68
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Asp Met Gly Thr Gln Gly Ser Gly Arg Lys Arg Leu Pro Asn Arg 
1               5                   10                  15      


Glu Arg Leu Thr Ala Glu Asp Asp Ala Leu Asn Gln Ile Ala Arg Glu 
            20                  25                  30          


Ala Glu Ala Arg Leu Ala Ala Lys Arg Ala Ala Arg Ala Glu Ala Arg 
        35                  40                  45              


Glu Ile Arg Met Lys Glu Leu Glu Arg Gln Gln Lys Glu Ile Tyr Gln 
    50                  55                  60                  


Val Gln Lys Lys Tyr Tyr Gly Leu Asp Thr Lys Trp Gly Asp Ile Glu 
65                  70                  75                  80  


Gln Trp Met Glu Asp Ser Glu Arg Tyr Ser Arg Arg Ser Arg Arg Asn 
                85                  90                  95      


Thr Ser Ala Ser Asp Glu Asp Glu Arg Met Ser Val Gly Ser Arg Gly 
            100                 105                 110         


Ser Leu Arg Ser Gln Pro Asp Leu Glu Tyr Gly Gly Pro Tyr Ala Trp 
        115                 120                 125             


Thr Asn Gly Tyr Asp Gly Glu Leu Tyr Gly Ser Gln Ser Leu Asn Arg 
    130                 135                 140                 


Arg Ser Gly Arg Pro Ser Cys Leu Tyr Ser Ala Ala Arg Pro Ser Gly 
145                 150                 155                 160 


Ser Tyr Arg Ala Ser Val Leu Asp Glu Gly Ser Phe Gly Gly Thr Arg 
                165                 170                 175     


Arg Gly Ser Thr Ser Gly Ser Arg Ala Pro Ser Glu Tyr Ser Gly His 
            180                 185                 190         


Leu Asn Ser Ser Ser Arg Ala Ser Ser Arg Ala Ser Ser Ala Arg Ala 
        195                 200                 205             


Ser Pro Val Val Glu Glu Arg Pro Glu Lys Asp Phe Thr Glu Lys Gly 
    210                 215                 220                 


Ser Arg Asn Met Pro Gly Leu Ser Ala Ala Thr Leu Ala Ser Leu Gly 
225                 230                 235                 240 


Gly Thr Ser Ser Arg Arg Gly Ser Gly Asp Thr Ser Ile Ser Ile Asp 
                245                 250                 255     


Thr Glu Ala Ser Ile Arg Glu Ile Lys Glu Leu Asn Glu Leu Lys Asp 
            260                 265                 270         


Gln Ile Gln Asp Val Glu Gly Lys Tyr Met Gln Gly Leu Lys Glu Met 
        275                 280                 285             


Lys Asp Ser Leu Ala Glu Val Glu Glu Lys Tyr Lys Lys Ala Met Val 
    290                 295                 300                 


Ser Asn Ala Gln Leu Asp Asn Glu Lys Thr Asn Phe Met Tyr Gln Val 
305                 310                 315                 320 


Asp Thr Leu Lys Asp Met Leu Leu Glu Leu Glu Glu Gln Leu Ala Glu 
                325                 330                 335     


Ser Arg Arg Gln Tyr Glu Glu Lys Asn Lys Glu Phe Glu Arg Glu Lys 
            340                 345                 350         


His Ala His Ser Ile Leu Gln Phe Gln Phe Ala Glu Val Lys Glu Ala 
        355                 360                 365             


Leu Lys Gln Arg Glu Glu Met Leu Glu Glu Ile Arg Gln Leu Gln Gln 
    370                 375                 380                 


Lys Gln Ala Ser Ser Ile Arg Glu Ile Ser Asp Leu Gln Glu Thr Ile 
385                 390                 395                 400 


Glu Trp Lys Asp Lys Lys Ile Gly Ala Leu Glu Arg Gln Lys Glu Phe 
                405                 410                 415     


Phe Asp Ser Val Arg Ser Glu Arg Asp Asp Leu Arg Glu Glu Val Val 
            420                 425                 430         


Met Leu Lys Glu Glu Leu Lys Lys His Gly Ile Ile Leu Asn Ser Glu 
        435                 440                 445             


Ile Ala Thr Asn Gly Glu Thr Ser Asp Thr Leu Asn Asn Val Gly Tyr 
    450                 455                 460                 


Gln Gly Pro Thr Lys Met Thr Lys Glu Glu Leu Asn Ala Leu Lys Ser 
465                 470                 475                 480 


Thr Gly Asp Gly Thr Leu Asp Ile Arg Leu Lys Lys Leu Val Asp Glu 
                485                 490                 495     


Arg Glu Cys Leu Leu Glu Gln Ile Lys Lys Leu Lys Gly Gln Leu Glu 
            500                 505                 510         


Glu Arg Gln Lys Ile Gly Lys Leu Asp Asn Leu Arg Ser Glu Asp Asp 
        515                 520                 525             


Val Leu Glu Asn Gly Thr Asp Met His Val Met Asp Leu Gln Arg Asp 
    530                 535                 540                 


Ala Asn Arg Gln Ile Ser Asp Leu Lys Phe Lys Leu Ala Lys Ser Glu 
545                 550                 555                 560 


Gln Glu Ile Thr Ala Leu Glu Gln Asn Val Ile Arg Leu Glu Ser Gln 
                565                 570                 575     


Val Ser Arg Tyr Lys Ser Ala Ala Glu Asn Ala Glu Lys Ile Glu Asp 
            580                 585                 590         


Glu Leu Lys Ala Glu Lys Arg Lys Leu Gln Arg Glu Leu Arg Ser Ala 
        595                 600                 605             


Leu Asp Lys Thr Glu Glu Leu Glu Val Ser Asn Gly His Leu Val Lys 
    610                 615                 620                 


Arg Leu Glu Lys Met Lys Ala Asn Arg Ser Ala Leu Leu Ser Gln Gln 
625                 630                 635                 640 


<210>  69
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Thr Ser Pro Ala Ala Ala Gln Ser Arg Glu Ile Asp Cys Leu Ser 
1               5                   10                  15      


Pro Glu Ala Gln Lys Leu Ala Glu Ala Arg Leu Ala Ala Lys Arg Ala 
            20                  25                  30          


Ala Arg Ala Glu Ala Arg Glu Ile Arg Met Lys Glu Leu Glu Arg Gln 
        35                  40                  45              


Gln Lys Glu Val Glu Glu Arg Pro Glu Lys Asp Phe Thr Glu Lys Gly 
    50                  55                  60                  


Ser Arg Asn Met Pro Gly Leu Ser Ala Ala Thr Leu Ala Ser Leu Gly 
65                  70                  75                  80  


Gly Thr Ser Ser Arg Arg Gly Ser Gly Asp Thr Ser Ile Ser Ile Asp 
                85                  90                  95      


Thr Glu Ala Ser Ile Arg Glu Ile Lys Asp Ser Leu Ala Glu Val Glu 
            100                 105                 110         


Glu Lys Tyr Lys Lys Ala Met Val Ser Asn Ala Gln Leu Asp Asn Glu 
        115                 120                 125             


Lys Thr Asn Phe Met Tyr Gln Val Asp Thr Leu Lys Asp Met Leu Leu 
    130                 135                 140                 


Glu Leu Glu Glu Gln Leu Ala Glu Ser Arg Arg Gln Tyr Glu Glu Lys 
145                 150                 155                 160 


Asn Lys Glu Phe Glu Arg Glu Lys His Ala His Ser Ile Leu Gln Phe 
                165                 170                 175     


Gln Phe Ala Glu Val Lys Glu Ala Leu Lys Gln Arg Glu Glu Met Leu 
            180                 185                 190         


Glu Lys His Gly Ile Ile Leu Asn Ser Glu Ile Ala Thr Asn Gly Glu 
        195                 200                 205             


Thr Ser Asp Thr Leu Asn Asn Val Gly Tyr Gln Gly Pro Thr Lys Met 
    210                 215                 220                 


Thr Lys Glu Glu Leu Asn Ala Leu Lys Ser Thr Gly Asp Gly Thr Leu 
225                 230                 235                 240 


Gly Arg Ala Ser Glu Val Glu Val Lys Asn Glu Ile Val Ala Asn Val 
                245                 250                 255     


Gly Lys Arg Glu Ile Leu His Asn Thr Glu Lys Glu Gln His Thr Glu 
            260                 265                 270         


Asp Thr Val Lys Asp Cys Val Asp Ile Glu Val Phe Pro Ala Gly Glu 
        275                 280                 285             


Asn Thr Glu Asp Gln Lys Ser Ser Glu Asp Thr Ala Pro Phe Leu Gly 
    290                 295                 300                 


Thr Leu Ala Gly Ala Thr Tyr Glu Glu Gln Val Gln Ser Gln Ile Leu 
305                 310                 315                 320 


Glu Ser Ser Ser Leu Pro Glu Asn Thr Val Gln Val Glu Ser Asn Glu 
                325                 330                 335     


Val Met Gly Ala Pro Asp Asp Arg Thr Arg Thr Pro Leu Glu Pro Ser 
            340                 345                 350         


Asn Cys Trp Ser Asp Leu Asp Gly Gly Asn His Thr Glu Asn Val Gly 
        355                 360                 365             


Glu Ala Ala Val Thr Gln Val Glu Glu Gln Ala Gly Thr Val Ala Ser 
    370                 375                 380                 


Cys Pro Leu Gly His Ser Asp Asp Thr Val Tyr His Asp Asp Lys Cys 
385                 390                 395                 400 


Met Val Glu Val Pro Gln Glu Leu Glu Thr Ser Thr Gly His Ser Leu 
                405                 410                 415     


Glu Lys Glu Phe Thr Asn Gln Glu Ala Ala Glu Pro Lys Glu Val Pro 
            420                 425                 430         


Ala His Ser Thr Glu Val Gly Arg Asp His Asn Glu Glu Glu Gly Glu 
        435                 440                 445             


Glu Thr Gly Leu Arg Asp Glu Lys Pro Ile Lys Thr Glu Val Pro Gly 
    450                 455                 460                 


Ser Pro Ala Gly Thr Glu Gly Asn Cys Gln Glu Ala Thr Gly Pro Ser 
465                 470                 475                 480 


Thr Val Asp Thr Gln Asn Glu Pro Leu Asp Met Lys Glu Pro Asp Glu 
                485                 490                 495     


Glu Lys Ser Asp Gln Gln Gly Glu Ala Leu Asp Ser Ser Gln Lys Lys 
            500                 505                 510         


Thr Lys Asn Lys Lys Lys Lys Asn Lys Lys Lys Lys Ser Pro Val Pro 
        515                 520                 525             


Val Glu Thr Leu Lys Asp Val Lys Lys Glu Leu Thr Tyr Gln Asn Thr 
    530                 535                 540                 


Asp Leu Ser Glu Ile Lys Glu Glu Glu Gln Val Lys Ser Thr Asp Arg 
545                 550                 555                 560 


Lys Ser Ala Val Glu Ala Gln Asn Glu Val Thr Glu Asn Pro Lys Gln 
                565                 570                 575     


Lys Ile Ala Ala Glu Ser Ser Glu Asn Val Asp Cys Pro Glu Asn Pro 
            580                 585                 590         


Lys Ile Lys Leu Asp Gly Lys Leu Asp Gln Glu Gly Asp Asp Val Gln 
        595                 600                 605             


Thr Ala Ala Glu Glu Val Leu Ala Asp Gly Asp Thr Leu Asp Phe Glu 
    610                 615                 620                 


Asp Asp Thr Val Gln Ser Ser Gly Pro Arg Ala Gly Gly Glu Glu Leu 
625                 630                 635                 640 


Asp Glu Gly Val Ala Lys Asp Asn Ala Lys Ile Asp Gly Ala Thr Gln 
                645                 650                 655     


Ser Ser Pro Ala Glu Pro Lys Ser Glu Asp Ala Asp Arg Cys Thr Leu 
            660                 665                 670         


Pro Glu His Glu Ser Pro Ser Gln Asp Ile Ser Asp Ala Cys Glu Ala 
        675                 680                 685             


Glu Ser Thr Glu Arg Cys Glu Met Ser Glu His Pro Ser Gln Thr Val 
    690                 695                 700                 


Arg Lys Ala Leu Asp Ser Asn Ser Leu Glu Asn Asp Asp Leu Ser Ala 
705                 710                 715                 720 


Pro Gly Arg Glu Pro Gly His Phe Asn Pro Glu Ser Arg Glu Asp Thr 
                725                 730                 735     


Arg Gly Gly Asn Glu Lys Gly Lys Ser Lys Glu Asp Cys Thr Met Ser 
            740                 745                 750         


<210>  70
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Thr Ser Pro Ala Ala Ala Gln Ser Arg Glu Ile Asp Cys Leu Ser 
1               5                   10                  15      


Pro Glu Ala Gln Lys Leu Ala Glu Ala Arg Leu Ala Ala Lys Arg Ala 
            20                  25                  30          


Ala Arg Ala Glu Ala Arg Glu Ile Arg Met Lys Glu Leu Glu Arg Gln 
        35                  40                  45              


Gln Lys Glu Glu Asp Ser Glu Arg Tyr Ser Arg Arg Ser Arg Arg Asn 
    50                  55                  60                  


Thr Ser Ala Ser Asp Glu Asp Glu Arg Met Ser Val Gly Ser Arg Gly 
65                  70                  75                  80  


Ser Leu Arg Val Glu Glu Arg Pro Glu Lys Asp Phe Thr Glu Lys Gly 
                85                  90                  95      


Ser Arg Asn Met Pro Gly Leu Ser Ala Ala Thr Leu Ala Ser Leu Gly 
            100                 105                 110         


Gly Thr Ser Ser Arg Arg Gly Ser Gly Asp Thr Ser Ile Ser Ile Asp 
        115                 120                 125             


Thr Glu Ala Ser Ile Arg Glu Ile Lys Glu Leu Asn Glu Leu Lys Asp 
    130                 135                 140                 


Gln Ile Gln Asp Val Glu Gly Lys Tyr Met Gln Gly Leu Lys Glu Met 
145                 150                 155                 160 


Lys Asp Ser Leu Ala Glu Val Glu Glu Lys Tyr Lys Lys Ala Met Val 
                165                 170                 175     


Ser Asn Ala Gln Leu Asp Asn Glu Lys Thr Asn Phe Met Tyr Gln Val 
            180                 185                 190         


Asp Thr Leu Lys Asp Met Leu Leu Glu Leu Glu Glu Gln Leu Ala Glu 
        195                 200                 205             


Ser Arg Arg Gln Tyr Glu Glu Lys Asn Lys Glu Phe Glu Arg Glu Lys 
    210                 215                 220                 


His Ala His Ser Ile Leu Gln Phe Gln Phe Ala Glu Val Lys Glu Ala 
225                 230                 235                 240 


Leu Lys Gln Arg Glu Glu Met Leu Glu Lys His Gly Ile Ile Leu Asn 
                245                 250                 255     


Ser Glu Ile Ala Thr Asn Gly Glu Thr Ser Asp Thr Leu Asn Asn Val 
            260                 265                 270         


Gly Tyr Gln Gly Pro Thr Lys Met Thr Lys Glu Glu Leu Asn Ala Leu 
        275                 280                 285             


Lys Ser Thr Gly Asp Gly Thr Leu Gly Arg Ala Ser Glu Val Glu Val 
    290                 295                 300                 


Lys Asn Glu Ile Val Ala Asn Val Gly Lys Arg Glu Ile Leu His Asn 
305                 310                 315                 320 


Thr Glu Lys Glu Gln His Thr Glu Asp Thr Val Lys Asp Cys Val Asp 
                325                 330                 335     


Ile Glu Val Phe Pro Ala Gly Glu Asn Thr Glu Asp Gln Lys Ser Ser 
            340                 345                 350         


Glu Asp Thr Ala Pro Phe Leu Gly Thr Leu Ala Gly Ala Thr Tyr Glu 
        355                 360                 365             


Glu Gln Val Gln Ser Gln Ile Leu Glu Ser Ser Ser Leu Pro Glu Asn 
    370                 375                 380                 


Thr Val Gln Val Glu Ser Asn Glu Val Met Gly Ala Pro Asp Asp Arg 
385                 390                 395                 400 


Thr Arg Thr Pro Leu Glu Pro Ser Asn Cys Trp Ser Asp Leu Asp Gly 
                405                 410                 415     


Gly Asn His Thr Glu Asn Val Gly Glu Ala Ala Val Thr Gln Val Glu 
            420                 425                 430         


Glu Gln Ala Gly Thr Val Ala Ser Cys Pro Leu Gly His Ser Asp Asp 
        435                 440                 445             


Thr Val Tyr His Asp Asp Lys Cys Met Val Glu Val Pro Gln Glu Leu 
    450                 455                 460                 


Glu Thr Ser Thr Gly His Ser Leu Glu Lys Glu Phe Thr Asn Gln Glu 
465                 470                 475                 480 


Ala Ala Glu Pro Lys Glu Val Pro Ala His Ser Thr Glu Val Gly Arg 
                485                 490                 495     


Asp His Asn Glu Glu Glu Gly Glu Glu Thr Gly Leu Arg Asp Glu Lys 
            500                 505                 510         


Pro Ile Lys Thr Glu Val Pro Gly Ser Pro Ala Gly Thr Glu Gly Asn 
        515                 520                 525             


Cys Gln Glu Ala Thr Gly Pro Ser Thr Val Asp Thr Gln Asn Glu Pro 
    530                 535                 540                 


Leu Asp Met Lys Glu Pro Asp Glu Glu Lys Ser Asp Gln Gln Gly Glu 
545                 550                 555                 560 


Ala Leu Asp Ser Ser Gln Lys Lys Thr Lys Asn Lys Lys Lys Lys Asn 
                565                 570                 575     


Lys Lys Lys Lys Ser Pro Val Pro Val Glu Thr Leu Lys Asp Val Lys 
            580                 585                 590         


Lys Glu Leu Thr Tyr Gln Asn Thr Asp Leu Ser Glu Ile Lys Glu Glu 
        595                 600                 605             


Glu Gln Val Lys Ser Thr Asp Arg Lys Ser Ala Val Glu Ala Gln Asn 
    610                 615                 620                 


Glu Val Thr Glu Asn Pro Lys Gln Lys Ile Ala Ala Glu Ser Ser Glu 
625                 630                 635                 640 


Asn Val Asp Cys Pro Glu Asn Pro Lys Ile Lys Leu Asp Gly Lys Leu 
                645                 650                 655     


Asp Gln Glu Gly Asp Asp Val Gln Thr Ala Ala Glu Glu Val Leu Ala 
            660                 665                 670         


Asp Gly Asp Thr Leu Asp Phe Glu Asp Asp Thr Val Gln Ser Ser Gly 
        675                 680                 685             


Pro Arg Ala Gly Gly Glu Glu Leu Asp Glu Gly Val Ala Lys Asp Asn 
    690                 695                 700                 


Ala Lys Ile Asp Gly Ala Thr Gln Ser Ser Pro Ala Glu Pro Lys Ser 
705                 710                 715                 720 


Glu Asp Ala Asp Arg Cys Thr Leu Pro Glu His Glu Ser Pro Ser Gln 
                725                 730                 735     


Asp Ile Ser Asp Ala Cys Glu Ala Glu Ser Thr Glu Arg Cys Glu Met 
            740                 745                 750         


Ser Glu His Pro Ser Gln Thr Val Arg Lys Ala Leu Asp Ser Asn Ser 
        755                 760                 765             


Leu Glu Asn Asp Asp Leu Ser Ala Pro Gly Arg Glu Pro Gly His Phe 
    770                 775                 780                 


Asn Pro Glu Ser Arg Glu Asp Thr Arg Gly Gly Asn Glu Lys Gly Lys 
785                 790                 795                 800 


Ser Lys Glu Asp Cys Thr Met Ser 
                805             


<210>  71
<211>  2691
<212>  DNA
<213>  Homo sapiens

<400>  71
aatgcgaccc gaccgcgctg aggctccagg accgcccgcc atggctgcag gaggtcccgg       60

cgcggggtct gcggccccgg tctcctccac atcctccctt cccctggctg ctctcaacat      120

gcgagtgcgg cgccgcctgt ctctgttctt gaacgtgcgg acacaggtgg cggccgactg      180

gaccgcgctg gcggaggaga tggactttga gtacttggag atccggcaac tggagacaca      240

agcggacccc actggcaggc tgctggacgc ctggcaggga cgccctggcg cctctgtagg      300

ccgactgctc gagctgctta ccaagctggg ccgcgacgac gtgctgctgg agctgggacc      360

cagcattgag gaggattgcc aaaagtatat cttgaagcag cagcaggagg aggctgagaa      420

gcctttacag gtggccgctg tagacagcag tgtcccacgg acagcagagc tggcgggcat      480

caccacactt gatgaccccc tggggcatat gcctgagcgt ttcgatgcct tcatctgcta      540

ttgccccagc gacatccagt ttgtgcagga gatgatccgg caactggaac agacaaacta      600

tcgactgaag ttgtgtgtgt ctgaccgcga tgtcctgcct ggcacctgtg tctggtctat      660

tgctagtgag ctcatcgaaa agaggttggc tagaaggcca cggggtgggt gccgccggat      720

ggtggtggtt gtctctgatg attacctgca gagcaaggaa tgtgacttcc agaccaaatt      780

tgcactcagc ctctctccag gtgcccatca gaagcgactg atccccatca agtacaaggc      840

aatgaagaaa gagttcccca gcatcctgag gttcatcact gtctgcgact acaccaaccc      900

ctgcaccaaa tcttggttct ggactcgcct tgccaaggcc ttgtccctgc cctgaagact      960

gttctgaggc cctgggtgtg tgtgtatctg tctgcctgtc catgtacttc tgccctgcct     1020

cctcctttcg ttgtaggagg aatctgtgct ctacttacct ctcaattcct ggagatgcca     1080

acttcacaga cacgtctgca gcagctggac atcacatttc atgtcctgca tggaaccagt     1140

ggctgtgagt ggcatgtcca cttgctggat tatcagccag gacactatag aacaggacca     1200

gctgagacta agaaggacca gcagagccag ctcagctctg agccattcac acatcttcac     1260

cctcagtttc ctcacttgag gagtgggatg gggagaacag agagtagctg tgtttgaatc     1320

cctgtaggaa atggtgaagc atagctctgg gtctcctggg ggagaccagg cttggctgcg     1380

ggagagctgg ctgttgctgg actacatgct ggccactgct gtgaccacga cactgctggg     1440

gcagcttctt ccacagtgat gcctactgat gcttcagtgc ctctgcacac cgcccattcc     1500

acttcctcct tccccacagg gcaggtgggg aagcagtttg gcccagccca aggagacccc     1560

accttgagcc ttatttccta atgggtccac ctctcatctg catctttcac acctcccagc     1620

ttctgcccaa ccttcagcag tgacaagtcc ccaagagact cgcctgagca gcttgggctg     1680

cttttcattt ccacctgtca ggatgcctgt ggtcatgctc tcagctccac ctggcatgag     1740

aagggatcct ggcctctggc atattcatca agtatgagtt ctggggatga gtcactgtaa     1800

tgatgtgagc agggagcctt cctccctggg ccacctgcag agagctttcc caccaacttt     1860

gtaccttgat tgccttacaa agttatttgt ttacaaacag cgaccatata aaagcctcct     1920

gccccaaagc ttgtgggcac atgggcacat acagactcac atacagacac acacatatat     1980

gtacagacat gtactctcac acacacaggc accagcatac acacgttttt ctaggtacag     2040

ctcccaggaa cagctaggtg ggaaagtccc atcactgagg gagcctaacc atgtccctga     2100

acaaaaattg ggcactcatc tattcctttt ctcttgtgtc cctactcatt gaaaccaaac     2160

tctggaaagg acccaatgta ccagtattta tacctctaat gaagcacaga gagaggaaga     2220

gagctgctta aactcacaca acaatgaact gcagacacag ctgttctctc cctctctcct     2280

tcccagagca atttatactt taccctcagg ctgtcctctg gggagaaggt gccatggtct     2340

taggtgtctg tgccccagga cagaccctag gaccctaaat ccaatagaaa atgcatatct     2400

ttgctccact ttcagccagg ctggagcaag gtaccttttc ttaggatctt gggagggaat     2460

ggatgcccct ctctgcatga tcttgttgag gcatttagct gccatgcacc tgtccccctt     2520

taatactggg cattttaaag ccatctcaag aggcatcttc tacatgtttt gtacgcatta     2580

aaataatttc aaagatatct gagaaaagcc gatatttgcc attcttccta tatcctggaa     2640

tatatcttgc atcctgagtt tataataata aataatattc taccttggaa a              2691


<210>  72
<211>  2727
<212>  DNA
<213>  Homo sapiens

<400>  72
agattcctac ttcttacgcc ccccacatca cccgcctcga gacctcaagg gtagaggtgg       60

gcacccccgc ctccgcactt ttgctcgggg ctccagattg tagggcaggg cggcgcttct      120

cggaaagcga aagccggcgg ggcggggcgg gtgccgcagg agaaagagga agcgctggca      180

gacaatgcga cccgaccgcg ctgaggctcc aggaccgccc gccatggctg caggaggtcc      240

cggcgcgggg tctgcggccc cggtctcctc cacatcctcc cttcccctgg ctgctctcaa      300

catgcgagtg cggcgccgcc tgtctctgtt cttgaacgtg cggacacagg tggcggccga      360

ctggaccgcg ctggcggagg agatggactt tgagtacttg gagatccggc aactggagac      420

acaagcggac cccactggca ggctgctgga cgcctggcag ggacgccctg gcgcctctgt      480

aggccgactg ctcgagctgc ttaccaagct gggccgcgac gacgtgctgc tggagctggg      540

acccagcatt gggcatatgc ctgagcgttt cgatgccttc atctgctatt gccccagcga      600

catccagttt gtgcaggaga tgatccggca actggaacag acaaactatc gactgaagtt      660

gtgtgtgtct gaccgcgatg tcctgcctgg cacctgtgtc tggtctattg ctagtgagct      720

catcgaaaag aggtgccgcc ggatggtggt ggttgtctct gatgattacc tgcagagcaa      780

ggaatgtgac ttccagacca aatttgcact cagcctctct ccaggtgccc atcagaagcg      840

actgatcccc atcaagtaca aggcaatgaa gaaagagttc cccagcatcc tgaggttcat      900

cactgtctgc gactacacca acccctgcac caaatcttgg ttctggactc gccttgccaa      960

ggccttgtcc ctgccctgaa gactgttctg aggccctggg tgtgtgtgta tctgtctgcc     1020

tgtccatgta cttctgccct gcctcctcct ttcgttgtag gaggaatctg tgctctactt     1080

acctctcaat tcctggagat gccaacttca cagacacgtc tgcagcagct ggacatcaca     1140

tttcatgtcc tgcatggaac cagtggctgt gagtggcatg tccacttgct ggattatcag     1200

ccaggacact atagaacagg accagctgag actaagaagg accagcagag ccagctcagc     1260

tctgagccat tcacacatct tcaccctcag tttcctcact tgaggagtgg gatggggaga     1320

acagagagta gctgtgtttg aatccctgta ggaaatggtg aagcatagct ctgggtctcc     1380

tgggggagac caggcttggc tgcgggagag ctggctgttg ctggactaca tgctggccac     1440

tgctgtgacc acgacactgc tggggcagct tcttccacag tgatgcctac tgatgcttca     1500

gtgcctctgc acaccgccca ttccacttcc tccttcccca cagggcaggt ggggaagcag     1560

tttggcccag cccaaggaga ccccaccttg agccttattt cctaatgggt ccacctctca     1620

tctgcatctt tcacacctcc cagcttctgc ccaaccttca gcagtgacaa gtccccaaga     1680

gactcgcctg agcagcttgg gctgcttttc atttccacct gtcaggatgc ctgtggtcat     1740

gctctcagct ccacctggca tgagaaggga tcctggcctc tggcatattc atcaagtatg     1800

agttctgggg atgagtcact gtaatgatgt gagcagggag ccttcctccc tgggccacct     1860

gcagagagct ttcccaccaa ctttgtacct tgattgcctt acaaagttat ttgtttacaa     1920

acagcgacca tataaaagcc tcctgcccca aagcttgtgg gcacatgggc acatacagac     1980

tcacatacag acacacacat atatgtacag acatgtactc tcacacacac aggcaccagc     2040

atacacacgt ttttctaggt acagctccca ggaacagcta ggtgggaaag tcccatcact     2100

gagggagcct aaccatgtcc ctgaacaaaa attgggcact catctattcc ttttctcttg     2160

tgtccctact cattgaaacc aaactctgga aaggacccaa tgtaccagta tttatacctc     2220

taatgaagca cagagagagg aagagagctg cttaaactca cacaacaatg aactgcagac     2280

acagctgttc tctccctctc tccttcccag agcaatttat actttaccct caggctgtcc     2340

tctggggaga aggtgccatg gtcttaggtg tctgtgcccc aggacagacc ctaggaccct     2400

aaatccaata gaaaatgcat atctttgctc cactttcagc caggctggag caaggtacct     2460

tttcttagga tcttgggagg gaatggatgc ccctctctgc atgatcttgt tgaggcattt     2520

agctgccatg cacctgtccc cctttaatac tgggcatttt aaagccatct caagaggcat     2580

cttctacatg ttttgtacgc attaaaataa tttcaaagat atctgagaaa agccgatatt     2640

tgccattctt cctatatcct ggaatatatc ttgcatcctg agtttataat aataaataat     2700

attctacctt ggaaaaaaaa aaaaaaa                                         2727


<210>  73
<211>  2486
<212>  DNA
<213>  Homo sapiens

<400>  73
aatgcgaccc gaccgcgctg aggctccagg accgcccgcc atggctgcag gaggtcccgg       60

cgcggggtct gcggccccgg tctcctccac atcctccctt cccctggctg ctctcaacat      120

gcgagtgcgg cgccgcctgt ctctgttctt gaacgtgcgg acacaggtgg cggccgactg      180

gaccgcgctg gcggaggaga tggactttga gtacttggag atccggcaac tggagacaca      240

agcggacccc actggcaggc tgctggacgc ctggcaggga cgccctggcg cctctgtagg      300

ccgactgctc gagctgctta ccaagctggg ccgcgacgac gtgctgctgg agctgggacc      360

cagcattgag gaggattgcc aaaagtatat cttgaagcag cagcaggagg aggctgagaa      420

gcctttacag gtggccgctg tagacagcag tgtcccacgg acagcagagc tggcgggcat      480

caccacactt gatgaccccc tgggtgccgc cggatggtgg tggttgtctc tgatgattac      540

ctgcagagca aggaatgtga cttccagacc aaatttgcac tcagcctctc tccaggtgcc      600

catcagaagc gactgatccc catcaagtac aaggcaatga agaaagagtt ccccagcatc      660

ctgaggttca tcactgtctg cgactacacc aacccctgca ccaaatcttg gttctggact      720

cgccttgcca aggccttgtc cctgccctga agactgttct gaggccctgg gtgtgtgtgt      780

atctgtctgc ctgtccatgt acttctgccc tgcctcctcc tttcgttgta ggaggaatct      840

gtgctctact tacctctcaa ttcctggaga tgccaacttc acagacacgt ctgcagcagc      900

tggacatcac atttcatgtc ctgcatggaa ccagtggctg tgagtggcat gtccacttgc      960

tggattatca gccaggacac tatagaacag gaccagctga gactaagaag gaccagcaga     1020

gccagctcag ctctgagcca ttcacacatc ttcaccctca gtttcctcac ttgaggagtg     1080

ggatggggag aacagagagt agctgtgttt gaatccctgt aggaaatggt gaagcatagc     1140

tctgggtctc ctgggggaga ccaggcttgg ctgcgggaga gctggctgtt gctggactac     1200

atgctggcca ctgctgtgac cacgacactg ctggggcagc ttcttccaca gtgatgccta     1260

ctgatgcttc agtgcctctg cacaccgccc attccacttc ctccttcccc acagggcagg     1320

tggggaagca gtttggccca gcccaaggag accccacctt gagccttatt tcctaatggg     1380

tccacctctc atctgcatct ttcacacctc ccagcttctg cccaaccttc agcagtgaca     1440

agtccccaag agactcgcct gagcagcttg ggctgctttt catttccacc tgtcaggatg     1500

cctgtggtca tgctctcagc tccacctggc atgagaaggg atcctggcct ctggcatatt     1560

catcaagtat gagttctggg gatgagtcac tgtaatgatg tgagcaggga gccttcctcc     1620

ctgggccacc tgcagagagc tttcccacca actttgtacc ttgattgcct tacaaagtta     1680

tttgtttaca aacagcgacc atataaaagc ctcctgcccc aaagcttgtg ggcacatggg     1740

cacatacaga ctcacataca gacacacaca tatatgtaca gacatgtact ctcacacaca     1800

caggcaccag catacacacg tttttctagg tacagctccc aggaacagct aggtgggaaa     1860

gtcccatcac tgagggagcc taaccatgtc cctgaacaaa aattgggcac tcatctattc     1920

cttttctctt gtgtccctac tcattgaaac caaactctgg aaaggaccca atgtaccagt     1980

atttatacct ctaatgaagc acagagagag gaagagagct gcttaaactc acacaacaat     2040

gaactgcaga cacagctgtt ctctccctct ctccttccca gagcaattta tactttaccc     2100

tcaggctgtc ctctggggag aaggtgccat ggtcttaggt gtctgtgccc caggacagac     2160

cctaggaccc taaatccaat agaaaatgca tatctttgct ccactttcag ccaggctgga     2220

gcaaggtacc ttttcttagg atcttgggag ggaatggatg cccctctctg catgatcttg     2280

ttgaggcatt tagctgccat gcacctgtcc ccctttaata ctgggcattt taaagccatc     2340

tcaagaggca tcttctacat gttttgtacg cattaaaata atttcaaaga tatctgagaa     2400

aagccgatat ttgccattct tcctatatcc tggaatatat cttgcatcct gagtttataa     2460

taataaataa tattctacct tggaaa                                          2486


<210>  74
<211>  2351
<212>  DNA
<213>  Homo sapiens

<400>  74
aatgcgaccc gaccgcgctg aggctccagg accgcccgcc atggctgcag gaggtcccgg       60

cgcggggtct gcggccccgg tctcctccac atcctccctt cccctggctg ctctcaacat      120

gcgagtgcgg cgccgcctgt ctctgttctt gaacgtgcgg acacaggtgg cggccgactg      180

gaccgcgctg gcggaggaga tggactttga gtacttggag atccggcaac tggagacaca      240

agcggacccc actggcaggc tgctggacgc ctggcaggga cgccctggcg cctctgtagg      300

ccgactgctc gagctgctta ccaagctggg ccgcgacgac gtgctgctgg agctgggacc      360

cagcattggt gccgccggat ggtggtggtt gtctctgatg attacctgca gagcaaggaa      420

tgtgacttcc agaccaaatt tgcactcagc ctctctccag gtgcccatca gaagcgactg      480

atccccatca agtacaaggc aatgaagaaa gagttcccca gcatcctgag gttcatcact      540

gtctgcgact acaccaaccc ctgcaccaaa tcttggttct ggactcgcct tgccaaggcc      600

ttgtccctgc cctgaagact gttctgaggc cctgggtgtg tgtgtatctg tctgcctgtc      660

catgtacttc tgccctgcct cctcctttcg ttgtaggagg aatctgtgct ctacttacct      720

ctcaattcct ggagatgcca acttcacaga cacgtctgca gcagctggac atcacatttc      780

atgtcctgca tggaaccagt ggctgtgagt ggcatgtcca cttgctggat tatcagccag      840

gacactatag aacaggacca gctgagacta agaaggacca gcagagccag ctcagctctg      900

agccattcac acatcttcac cctcagtttc ctcacttgag gagtgggatg gggagaacag      960

agagtagctg tgtttgaatc cctgtaggaa atggtgaagc atagctctgg gtctcctggg     1020

ggagaccagg cttggctgcg ggagagctgg ctgttgctgg actacatgct ggccactgct     1080

gtgaccacga cactgctggg gcagcttctt ccacagtgat gcctactgat gcttcagtgc     1140

ctctgcacac cgcccattcc acttcctcct tccccacagg gcaggtgggg aagcagtttg     1200

gcccagccca aggagacccc accttgagcc ttatttccta atgggtccac ctctcatctg     1260

catctttcac acctcccagc ttctgcccaa ccttcagcag tgacaagtcc ccaagagact     1320

cgcctgagca gcttgggctg cttttcattt ccacctgtca ggatgcctgt ggtcatgctc     1380

tcagctccac ctggcatgag aagggatcct ggcctctggc atattcatca agtatgagtt     1440

ctggggatga gtcactgtaa tgatgtgagc agggagcctt cctccctggg ccacctgcag     1500

agagctttcc caccaacttt gtaccttgat tgccttacaa agttatttgt ttacaaacag     1560

cgaccatata aaagcctcct gccccaaagc ttgtgggcac atgggcacat acagactcac     1620

atacagacac acacatatat gtacagacat gtactctcac acacacaggc accagcatac     1680

acacgttttt ctaggtacag ctcccaggaa cagctaggtg ggaaagtccc atcactgagg     1740

gagcctaacc atgtccctga acaaaaattg ggcactcatc tattcctttt ctcttgtgtc     1800

cctactcatt gaaaccaaac tctggaaagg acccaatgta ccagtattta tacctctaat     1860

gaagcacaga gagaggaaga gagctgctta aactcacaca acaatgaact gcagacacag     1920

ctgttctctc cctctctcct tcccagagca atttatactt taccctcagg ctgtcctctg     1980

gggagaaggt gccatggtct taggtgtctg tgccccagga cagaccctag gaccctaaat     2040

ccaatagaaa atgcatatct ttgctccact ttcagccagg ctggagcaag gtaccttttc     2100

ttaggatctt gggagggaat ggatgcccct ctctgcatga tcttgttgag gcatttagct     2160

gccatgcacc tgtccccctt taatactggg cattttaaag ccatctcaag aggcatcttc     2220

tacatgtttt gtacgcatta aaataatttc aaagatatct gagaaaagcc gatatttgcc     2280

attcttccta tatcctggaa tatatcttgc atcctgagtt tataataata aataatattc     2340

taccttggaa a                                                          2351


<210>  75
<211>  2862
<212>  DNA
<213>  Homo sapiens

<400>  75
agattcctac ttcttacgcc ccccacatca cccgcctcga gacctcaagg gtagaggtgg       60

gcacccccgc ctccgcactt ttgctcgggg ctccagattg tagggcaggg cggcgcttct      120

cggaaagcga aagccggcgg ggcggggcgg gtgccgcagg agaaagagga agcgctggca      180

gacaatgcga cccgaccgcg ctgaggctcc aggaccgccc gccatggctg caggaggtcc      240

cggcgcgggg tctgcggccc cggtctcctc cacatcctcc cttcccctgg ctgctctcaa      300

catgcgagtg cggcgccgcc tgtctctgtt cttgaacgtg cggacacagg tggcggccga      360

ctggaccgcg ctggcggagg agatggactt tgagtacttg gagatccggc aactggagac      420

acaagcggac cccactggca ggctgctgga cgcctggcag ggacgccctg gcgcctctgt      480

aggccgactg ctcgagctgc ttaccaagct gggccgcgac gacgtgctgc tggagctggg      540

acccagcatt gaggaggatt gccaaaagta tatcttgaag cagcagcagg aggaggctga      600

gaagccttta caggtggccg ctgtagacag cagtgtccca cggacagcag agctggcggg      660

catcaccaca cttgatgacc ccctggggca tatgcctgag cgtttcgatg ccttcatctg      720

ctattgcccc agcgacatcc agtttgtgca ggagatgatc cggcaactgg aacagacaaa      780

ctatcgactg aagttgtgtg tgtctgaccg cgatgtcctg cctggcacct gtgtctggtc      840

tattgctagt gagctcatcg aaaagaggtg ccgccggatg gtggtggttg tctctgatga      900

ttacctgcag agcaaggaat gtgacttcca gaccaaattt gcactcagcc tctctccagg      960

tgcccatcag aagcgactga tccccatcaa gtacaaggca atgaagaaag agttccccag     1020

catcctgagg ttcatcactg tctgcgacta caccaacccc tgcaccaaat cttggttctg     1080

gactcgcctt gccaaggcct tgtccctgcc ctgaagactg ttctgaggcc ctgggtgtgt     1140

gtgtatctgt ctgcctgtcc atgtacttct gccctgcctc ctcctttcgt tgtaggagga     1200

atctgtgctc tacttacctc tcaattcctg gagatgccaa cttcacagac acgtctgcag     1260

cagctggaca tcacatttca tgtcctgcat ggaaccagtg gctgtgagtg gcatgtccac     1320

ttgctggatt atcagccagg acactataga acaggaccag ctgagactaa gaaggaccag     1380

cagagccagc tcagctctga gccattcaca catcttcacc ctcagtttcc tcacttgagg     1440

agtgggatgg ggagaacaga gagtagctgt gtttgaatcc ctgtaggaaa tggtgaagca     1500

tagctctggg tctcctgggg gagaccaggc ttggctgcgg gagagctggc tgttgctgga     1560

ctacatgctg gccactgctg tgaccacgac actgctgggg cagcttcttc cacagtgatg     1620

cctactgatg cttcagtgcc tctgcacacc gcccattcca cttcctcctt ccccacaggg     1680

caggtgggga agcagtttgg cccagcccaa ggagacccca ccttgagcct tatttcctaa     1740

tgggtccacc tctcatctgc atctttcaca cctcccagct tctgcccaac cttcagcagt     1800

gacaagtccc caagagactc gcctgagcag cttgggctgc ttttcatttc cacctgtcag     1860

gatgcctgtg gtcatgctct cagctccacc tggcatgaga agggatcctg gcctctggca     1920

tattcatcaa gtatgagttc tggggatgag tcactgtaat gatgtgagca gggagccttc     1980

ctccctgggc cacctgcaga gagctttccc accaactttg taccttgatt gccttacaaa     2040

gttatttgtt tacaaacagc gaccatataa aagcctcctg ccccaaagct tgtgggcaca     2100

tgggcacata cagactcaca tacagacaca cacatatatg tacagacatg tactctcaca     2160

cacacaggca ccagcataca cacgtttttc taggtacagc tcccaggaac agctaggtgg     2220

gaaagtccca tcactgaggg agcctaacca tgtccctgaa caaaaattgg gcactcatct     2280

attccttttc tcttgtgtcc ctactcattg aaaccaaact ctggaaagga cccaatgtac     2340

cagtatttat acctctaatg aagcacagag agaggaagag agctgcttaa actcacacaa     2400

caatgaactg cagacacagc tgttctctcc ctctctcctt cccagagcaa tttatacttt     2460

accctcaggc tgtcctctgg ggagaaggtg ccatggtctt aggtgtctgt gccccaggac     2520

agaccctagg accctaaatc caatagaaaa tgcatatctt tgctccactt tcagccaggc     2580

tggagcaagg taccttttct taggatcttg ggagggaatg gatgcccctc tctgcatgat     2640

cttgttgagg catttagctg ccatgcacct gtcccccttt aatactgggc attttaaagc     2700

catctcaaga ggcatcttct acatgttttg tacgcattaa aataatttca aagatatctg     2760

agaaaagccg atatttgcca ttcttcctat atcctggaat atatcttgca tcctgagttt     2820

ataataataa ataatattct accttggaaa aaaaaaaaaa aa                        2862


<210>  76
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Leu Ala Arg Arg Pro Arg Gly Gly Cys 
    210                 215                 220                 


Arg Arg Met Val Val Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu 
225                 230                 235                 240 


Cys Asp Phe Gln Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His 
                245                 250                 255     


Gln Lys Arg Leu Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe 
            260                 265                 270         


Pro Ser Ile Leu Arg Phe Ile Thr Val Cys Asp Tyr Thr Asn Pro Cys 
        275                 280                 285             


Thr Lys Ser Trp Phe Trp Thr Arg Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295                 300                 


<210>  77
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Gly His Met 
            100                 105                 110         


Pro Glu Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln 
        115                 120                 125             


Phe Val Gln Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu 
    130                 135                 140                 


Lys Leu Cys Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp 
145                 150                 155                 160 


Ser Ile Ala Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val 
                165                 170                 175     


Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr 
            180                 185                 190         


Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile 
        195                 200                 205             


Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg 
    210                 215                 220                 


Phe Ile Thr Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe 
225                 230                 235                 240 


Trp Thr Arg Leu Ala Lys Ala Leu Ser Leu Pro 
                245                 250     


<210>  78
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly Ala Ala Gly Trp Trp 
145                 150                 155                 160 


Trp Leu Ser Leu Met Ile Thr Cys Arg Ala Arg Asn Val Thr Ser Arg 
                165                 170                 175     


Pro Asn Leu His Ser Ala Ser Leu Gln Val Pro Ile Arg Ser Asp 
            180                 185                 190     


<210>  79
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Gly Ala Ala 
            100                 105                 110         


Gly Trp Trp Trp Leu Ser Leu Met Ile Thr Cys Arg Ala Arg Asn Val 
        115                 120                 125             


Thr Ser Arg Pro Asn Leu His Ser Ala Ser Leu Gln Val Pro Ile Arg 
    130                 135                 140                 


Ser Asp 
145     


<210>  80
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


<210>  81
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  81
gcatttccag agcagagttc agagaaaggc tgggctgctt gttgctggct aaaggacaaa       60

gggtaagttt caggaagcag aagagtgagc agatgaaatt cagcactggg atcaggggag      120

tgtctgattt gcaaaaggaa agtgcaaaga cagctcctcc cttctgagga aacgaaacca      180

acagcagtcc aagctcagtc agcagaagag ataaaagcaa acaggtctgg gaggcagttc      240

tgttgccact ctctctcctg tcaatgatgg atctcagaaa taccccagcc aaatctctgg      300

acaagttcat tgaagactat ctcttgccag acacgtgttt ccgcatgcaa atcaaccatg      360

ccattgacat catctgtggg ttcctgaagg aaaggtgctt ccgaggtagc tcctaccctg      420

tgtgtgtgtc caaggtggta aagggtggct cctcaggcaa gggcaccacc ctcagaggcc      480

gatctgacgc tgacctggtt gtcttcctca gtcctctcac cacttttcag gatcagttaa      540

atcgccgggg agagttcatc caggaaatta ggagacagct ggaagcctgt caaagagaga      600

gagcattttc cgtgaagttt gaggtccagg ctccacgctg gggcaacccc cgtgcgctca      660

gcttcgtact gagttcgctc cagctcgggg agggggtgga gttcgatgtg ctgcctgcct      720

ttgatgccct gggtcagttg actggcggct ataaacctaa cccccaaatc tatgtcaagc      780

tcatcgagga gtgcaccgac ctgcagaaag agggcgagtt ctccacctgc ttcacagaac      840

tacagagaga cttcctgaag cagcgcccca ccaagctcaa gagcctcatc cgcctagtca      900

agcactggta ccaaaattgt aagaagaagc ttgggaagct gccacctcag tatgccctgg      960

agctcctgac ggtctatgct tgggagcgag ggagcatgaa aacacatttc aacacagccc     1020

agggatttcg gacggtcttg gaattagtca taaactacca gcaactctgc atctactgga     1080

caaagtatta tgactttaaa aaccccatta ttgaaaagta cctgagaagg cagctcacga     1140

aacccaggcc tgtgatcctg gacccggcgg accctacagg aaacttgggt ggtggagacc     1200

caaagggttg gaggcagctg gcacaagagg ctgaggcctg gctgaattac ccatgcttta     1260

agaattggga tgggtcccca gtgagctcct ggattctgct ggtaaacctc acactggttg     1320

gcagaaggaa ctataccaat aattagtgaa catgcggtga atttgcaaca gacaagagga     1380

gcctcattat cctatagttt ccaggttgct tagggaggca gaaatcacag caaggaaaac     1440

cttcaataat aaacagacgt ctcataaaat taattgcaac ccaacctctc tctctactta     1500

aaattagcat ctatttccag ctctgctttc aatgccccat atgaatacat gtgaactccc     1560

tccctctctt cctccctgtc tccttctctc tctctctgtc cctcattaaa aaat           1614


<210>  82
<211>  1627
<212>  DNA
<213>  Homo sapiens

<400>  82
gcatttccag agcagagttc agagaaaggc tgggctgctt gttgctggct aaaggacaaa       60

gggtaagttt caggaagcag aagagtgagc agatgaaatt cagcactggg atcaggggag      120

tgtctgattt gcaaaaggaa agtgcaaaga cagctcctcc cttctgagga aacgaaacca      180

acagcagtcc aagctcagtc agcagaagag ataaaagcaa acaggtctgg gaggcagttc      240

tgttgccact ctctctcctg tcaatgatgg atctcagaaa taccccagcc aaatctctgg      300

acaagttcat tgaagactat ctcttgccag acacgtgttt ccgcatgcaa atcaaccatg      360

ccattgacat catctgtggg ttcctgaagg aaaggtgctt ccgaggtagc tcctaccctg      420

tgtgtgtgtc caaggtggta aagggtggct cctcaggcaa gggcaccacc ctcagaggcc      480

gatctgacgc tgacctggtt gtcttcctca gtcctctcac cacttttcag gatcagttaa      540

atcgccgggg agagttcatc caggaaatta ggagacagct ggaagcctgt caaagagaga      600

gagcattttc cgtgaagttt gaggtccagg ctccacgctg gggcaacccc cgtgcgctca      660

gcttcgtact gagttcgctc cagctcgggg agggggtgga gttcgatgtg ctgcctgcct      720

ttgatgccct gggtcagttg actggcggct ataaacctaa cccccaaatc tatgtcaagc      780

tcatcgagga gtgcaccgac ctgcagaaag agggcgagtt ctccacctgc ttcacagaac      840

tacagagaga cttcctgaag cagcgcccca ccaagctcaa gagcctcatc cgcctagtca      900

agcactggta ccaaaattgt aagaagaagc ttgggaagct gccacctcag tatgccctgg      960

agctcctgac ggtctatgct tgggagcgag ggagcatgaa aacacatttc aacacagccc     1020

agggatttcg gacggtcttg gaattagtca taaactacca gcaactctgc atctactgga     1080

caaagtatta tgactttaaa aaccccatta ttgaaaagta cctgagaagg cagctcacga     1140

aacccaggcc tgtgatcctg gacccggcgg accctacagg aaacttgggt ggtggagacc     1200

caaagggttg gaggcagctg gcacaagagg ctgaggcctg gctgaattac ccatgcttta     1260

agaattggga tgggtcccca gtgagctcct ggattctgct ggtgagacct cctgcttcct     1320

ccctgccatt catccctgcc cctctccatg aagcttgaga catatagctg gagaccattc     1380

tttccaaaga acttacctct tgccaaaggc catttatatt catatagtga caggctgtgc     1440

tccatatttt acagtcattt tggtcacaat cgagggtttc tggaattttc acatcccttg     1500

tccagaattc attcccctaa gagtaataat aaataatctc taacaccatt tattgactgt     1560

ctgcttcggg ctcaggttct gtcctaagcc ctttaatatg cactctctca ttaaatagtc     1620

acaacaa                                                               1627


<210>  83
<211>  1533
<212>  DNA
<213>  Homo sapiens

<400>  83
agtccaagct cagtcagcag aagagataaa agcaaacagg tctgggaggc agttctgttg       60

ccactctctc tcctgtcaat gatggatctc agaaataccc cagccaaatc tctggacaag      120

ttcattgaag actatctctt gccagacacg tgtttccgca tgcaaatcaa ccatgccatt      180

gacatcatct gtgggttcct gaaggaaagg tgcttccgag gtagctccta ccctgtgtgt      240

gtgtccaagg tggtaaaggg tggctcctca ggcaagggca ccaccctcag aggccgatct      300

gacgctgacc tggttgtctt cctcagtcct ctcaccactt ttcaggatca gttaaatcgc      360

cggggagagt tcatccagga aattaggaga cagctggaag cctgtcaaag agagagagca      420

ttttccgtga agtttgaggt ccaggctcca cgctggggca acccccgtgc gctcagcttc      480

gtactgagtt cgctccagct cggggagggg gtggagttcg atgtgctgcc tgcctttgat      540

gccctgggtc agttgactgg cggctataaa cctaaccccc aaatctatgt caagctcatc      600

gaggagtgca ccgacctgca gaaagagggc gagttctcca cctgcttcac agaactacag      660

agagacttcc tgaagcagcg ccccaccaag ctcaagagcc tcatccgcct agtcaagcac      720

tggtaccaaa attgtaagaa gaagcttggg aagctgccac ctcagtatgc cctggagctc      780

ctgacggtct atgcttggga gcgagggagc atgaaaacac atttcaacac agcccaggga      840

tttcggacgg tcttggaatt agtcataaac taccagcaac tctgcatcta ctggacaaag      900

tattatgact ttaaaaaccc cattattgaa aagtacctga gaaggcagct cacgaaaccc      960

aggcctgtga tcctggaccc ggcggaccct acaggaaact tgggtggtgg agacccaaag     1020

ggttggaggc agctggcaca agaggctgag gcctggctga attacccatg ctttaagaat     1080

tgggatgggt ccccagtgag ctcctggatt ctgctgaccc agcacactcc aggcagcatc     1140

caccccacag gcagaagagg actggacctg caccatcctc tgaatgccag tgcatcttgg     1200

gggaaagggc tccagtgtta tctggaccag ttccttcatt ttcaggtggg actcttgatc     1260

cagagaggac aaagctcctc agtgagctgg tgtataatcc aggacagaac ccaggtctcc     1320

tgactcctgg ccttctatgc cctctatcct atcatagata acattctcca cagcctcact     1380

tcattccacc tattctctga aaatattccc tgagagagaa cagagagatt tagataagag     1440

aatgaaattc cagccttgac tttcttctgt gcacctgatg ggagggtaat gtctaatgta     1500

ttatcaataa caataaaaat aaagcaaata cca                                  1533


<210>  84
<211>  1631
<212>  DNA
<213>  Homo sapiens

<400>  84
agtccaagct cagtcagcag aagagataaa agcaaacagg tctgggaggc agttctgttg       60

ccactctctc tcctgtcaat gatggatctc agaaataccc cagccaaatc tctggacaag      120

ttcattgaag actatctctt gccagacacg tgtttccgca tgcaaatcaa ccatgccatt      180

gacatcatct gtgggttcct gaaggaaagg tgcttccgag gtagctccta ccctgtgtgt      240

gtgtccaagg tggtaaaggg tggctcctca ggcaagggca ccaccctcag aggccgatct      300

gacgctgacc tggttgtctt cctcagtcct ctcaccactt ttcaggatca gttaaatcgc      360

cggggagagt tcatccagga aattaggaga cagctggaag cctgtcaaag agagagagca      420

ttttccgtga agtttgaggt ccaggctcca cgctggggca acccccgtgc gctcagcttc      480

gtactgagtt cgctccagct cggggagggg gtggagttcg atgtgctgcc tgcctttgat      540

gccctgggtc agttgactgg cggctataaa cctaaccccc aaatctatgt caagctcatc      600

gaggagtgca ccgacctgca gaaagagggc gagttctcca cctgcttcac agaactacag      660

agagacttcc tgaagcagcg ccccaccaag ctcaagagcc tcatccgcct agtcaagcac      720

tggtaccaaa attgtaagaa gaagcttggg aagctgccac ctcagtatgc cctggagctc      780

ctgacggtct atgcttggga gcgagggagc atgaaaacac atttcaacac agcccaggga      840

tttcggacgg tcttggaatt agtcataaac taccagcaac tctgcatcta ctggacaaag      900

tattatgact ttaaaaaccc cattattgaa aagtacctga gaaggcagct cacgaaaccc      960

aggcctgtga tcctggaccc ggcggaccct acaggaaact tgggtggtgg agacccaaag     1020

ggttggaggc agctggcaca agaggctgag gcctggctga attacccatg ctttaagaat     1080

tgggatgggt ccccagtgag ctcctggatt ctgctggctg aaagcaacag tgcagacgat     1140

gagaccgacg atcccaggag gtatcagaaa tatggttaca ttggaacaca tgagtaccct     1200

catttctctc atagacccag cacactccag gcagcatcca ccccacaggc agaagaggac     1260

tggacctgca ccatcctctg aatgccagtg catcttgggg gaaagggctc cagtgttatc     1320

tggaccagtt ccttcatttt caggtgggac tcttgatcca gagaggacaa agctcctcag     1380

tgagctggtg tataatccag gacagaaccc aggtctcctg actcctggcc ttctatgccc     1440

tctatcctat catagataac attctccaca gcctcacttc attccaccta ttctctgaaa     1500

atattccctg agagagaaca gagagattta gataagagaa tgaaattcca gccttgactt     1560

tcttctgtgc acctgatggg agggtaatgt ctaatgtatt atcaataaca ataaaaataa     1620

agcaaatacc a                                                          1631


<210>  85
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Val Asn Leu Thr Leu Val 
            340                 345                 350         


Gly Arg Arg Asn Tyr Thr Asn Asn 
        355                 360 


<210>  86
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Val Arg Pro Pro Ala Ser 
            340                 345                 350         


Ser Leu Pro Phe Ile Pro Ala Pro Leu His Glu Ala 
        355                 360                 


<210>  87
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Thr Gln His Thr Pro Gly 
            340                 345                 350         


Ser Ile His Pro Thr Gly Arg Arg Gly Leu Asp Leu His His Pro Leu 
        355                 360                 365             


Asn Ala Ser Ala Ser Trp Gly Lys Gly Leu Gln Cys Tyr Leu Asp Gln 
    370                 375                 380                 


Phe Leu His Phe Gln Val Gly Leu Leu Ile Gln Arg Gly Gln Ser Ser 
385                 390                 395                 400 


Ser Val Ser Trp Cys Ile Ile Gln Asp Arg Thr Gln Val Ser 
                405                 410                 


<210>  88
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Ala Glu Ser Asn Ser Ala 
            340                 345                 350         


Asp Asp Glu Thr Asp Asp Pro Arg Arg Tyr Gln Lys Tyr Gly Tyr Ile 
        355                 360                 365             


Gly Thr His Glu Tyr Pro His Phe Ser His Arg Pro Ser Thr Leu Gln 
    370                 375                 380                 


Ala Ala Ser Thr Pro Gln Ala Glu Glu Asp Trp Thr Cys Thr Ile Leu 
385                 390                 395                 400 


<210>  89
<211>  10744
<212>  DNA
<213>  Homo sapiens

<400>  89
attctccgcg gcgcggcggc gagtgctggc tgcggtaccc tcccgctcgc ttgtccgtct       60

gcgcgcccgc gatgtgacca gccgactggg ggcgggctgg cggctctgcc tgcggcagcg      120

catcggtttt tctcctggca ggtccctaat tgagccgtga ttcccttgga gccagagaca      180

cccaccaggg gctcggagcg ccgcgctccg gggctggagg cagctgcagc gctcgggtcc      240

gcgcggccgg gtgcagtagc ctcagtccca gccgccgcct cgctgagtcg tgtgccctgg      300

cgaatgcccg gcgcccggca cagctgagcc aaggcgactg gtgcagagcg gcggcgcctg      360

gtcctgcact tgccgctgct gccgggctgt gccggggcgg cggcgctgcg cgccggagtt      420

tgcagaggct gcctccgagc gccgtccgcc aggaagactc cctgcctcct gagtcccaaa      480

aacacgagat ttttctccta tttcagcagt tggccacaac ttcattgctg ggaaaaggcc      540

aagaaagaag agagaactct caccacaaca tttcaaaggg aatacattgc cagaacttgg      600

aatactctac tggacaaaca tttcctccaa ggacacagct ctctgcctcc atgtcaccac      660

ctttgaagga ctgactgatt ccctcggctg gtgccagtgc ctgctcctgc catggggccc      720

gcggggagcc tgctgggcag cggacagatg cagatcaccc tgtggggaag tctggctgct      780

gtcgccattt tcttcgtcat caccttcctc atcttcctgt gctctagttg tgacagggaa      840

aagaagccgc gacagcatag tggggaccat gagaacctga tgaacgtgcc ttcagacaag      900

gagatgttca gccgttcagt tactagcctg gcaacagatg ctcctgccag cagtgagcag      960

aatggggcac tcaccaatgg ggacattctt tcagaggaca gtactctgac ctgcatgcag     1020

cattacgagg aagtccagac atcggcctcg gatctgctgg attcccagga cagcacaggg     1080

aaaccaaaat gtcatcagag tcgggagctg cccagaatcc ctcccgagag cgcagtggat     1140

accatgctca cggcgagaag tgtggacggg gaccaggggc tggggatgga agggccctat     1200

gaagtgctca aggacagctc ctcccaagaa aacatggtgg aggactgctt gtatgaaact     1260

gtgaaagaga tcaaggaggt ggctgcagct gcacacctgg agaaaggcca cagtggcaag     1320

gcaaaatcta cttctgcctc gaaagagctc ccagggcccc agactgaagg caaagctgag     1380

tttgctgaat atgcctcggt ggacagaaac aaaaaatgtc gtcaaagtgt taatgtagag     1440

agtatccttg gaaattcatg tgatccagaa gaggaggccc caccacctgt ccctgttaag     1500

cttctggacg agaatgaaaa ccttcaggag aaggaagggg gagaggcgga agagagtgcc     1560

acagacacga ccagtgaaac taacaagaga tttagctcat tgtcatacaa gtctcgggaa     1620

gaagacccca ctctcacaga agaagagatc tcagctatgt actcatcagt aaataaacct     1680

ggacagttag tgaataaatc ggggcagtcg cttacagttc cggagtccac ctacacctcc     1740

attcaagggg acccacagag gtcaccctcc tcctgtaatg atctctatgc tactgttaaa     1800

gacttcgaaa aaactccaaa cagcacactt ccaccagcag ggaggcccag cgaggagcca     1860

gagcctgatt atgaagcgat acagactctc aacagagagg aagaaaaggc caccctgggg     1920

accaatggcc accacggtct cgtcccaaag gagaacgact acgagagcat aagtgacttg     1980

cagcaaggca gagatattac caggctctag caacccagaa gacaaccctg ggtagcctgt     2040

gatcagtgtc tggagacgtt tcttctgtgg aagagaagaa gtgacacaaa cctatacttc     2100

atatgctgct ttagtcacct gaagatggtt ggagaggccc tgtcgactgt tctcccagtt     2160

gttcagtttc tgagacagag aggtacggac taggctgcac ctgagtgtgc ccctgcctgc     2220

cagatggaca ggtacaccca agcacatctc cctgctgcac cctcaccacc cacaaaagat     2280

cccagctgtc agtggtctca tctcattagt gaggaaagcc aagctgtatg gaaaagctgc     2340

actcaccaag gaccacaatg cccccggcct aaagtactgc cattcagaaa agcaggtttt     2400

tcttcctctc tttccttttc tctgtctgct actgacttta aggctttttc ccccttgaaa     2460

tgtccagatt cctgtggttc atcccaagga aattttcaca caaagcttgg cctttgccct     2520

caatataggt gttttaggat ggtgacaaac catggctgct gctttctgcc cagctcgcca     2580

gtcctcccca aagagttgcg catcagcacc tggggatctg gaccctgcgg gtgaagggat     2640

ggggagggac gtccctggag tctcttctgt ctttgttcct tcttattttg gcattcgata     2700

tcagcagcct ctccccaaag tacttgaagt cagttttaga tgctttattt tatttttcta     2760

gtcaaaaacg tgtttccccc agtgtttgaa aactcgtccg aatcttttca gtattttcca     2820

tgagtattgt ggtacttcta gacttgttta agcccagaac tcattccttc aaaacagaga     2880

gccttaatct ttatgttggg acacagacca catatttgga cggcagccat gcatccatcg     2940

ctgaagggct gtggacatga atgtgtattt cccatggtct ccgctgccca caccaacagt     3000

gtggcatctc ataagttaac tgctacccta aggtaatcta agattaaaat gtaaacattt     3060

atttttgtta tgtaagttta taagatgttt tatgttcaat gcctaatttc tcaaaagtgc     3120

cagaaaaaaa tgtatattag ctattttgat tttatgtaca atgatttata ctctcctttt     3180

gaaaagatac cataaagcac ataagctaga tcactacaag gagctgttat cttttttcta     3240

atcaagtgtt taaaacactg atggttttta aagactcacc tttttaaatg gtacttggag     3300

ctcctgattc aaattaccta gaccccctag agaaataaat ggaatataca taaataatca     3360

ttttcagtgg tttatggtgg gcaatattgc aatatttgaa atggtaaaaa tggaaagaag     3420

aacaaaatat gatgagaggt ggctgtgaat tataaacctc ataaaagtgt cataattcca     3480

ttaaggttta attatatttt ttcagaaaac agtgatgaat tctgtagtcc agtgcttgcc     3540

aatgcaaatt gcctattgga atcttcttcc tatattttac aaacatcagt ggctgaaata     3600

gctcagagta agagctcagc ctggtttgaa tttaatcatc tctttagatc ttataaggcc     3660

agcattagga aacttgttca cttttcattt tcaaaggagc ctagttgaag tgctattatg     3720

agtgtgggct atggaaagac agcttttcct acactgataa agaaaaaaaa tgaggaaatt     3780

atttcatccc cttgtgacat ctgtgacttt ttggatttaa taatcttgct gtttttcctc     3840

tttatgacaa agaatataat tgggaggatg aagtgtctta aaaattgtag agaccagctc     3900

actggaatgt ttttccatcc ctgtattcat ggcttgactt tgtgactgct ctacactgca     3960

tgtctgacat tgcagagtga gctatgttga ggtaaactgg ttggttgtca ttattttgca     4020

atcagcctgg tctctcccat gaagatgtcg tgtgcataag cacaatcatc actgattaga     4080

agatcacagc agaataccct tggattagag agaagttcgt accttgcatt tctctgaatt     4140

ctagtctctc ataagcactg ctttgctgga tgattttcac tgctttgtgt taatgacttt     4200

gagcgatctc tcacatgatg gggttcttta gtacatggta acagccatgt catcttacac     4260

acctagcatt gtgaatgctg tagtgacatc ctttataggc accttacagc tcaaaacttt     4320

tgtttcattt catgccttac ttatcaaaaa ggcaggaaag taggtatgat ctctaaagta     4380

aaaaaaaaaa aaaaaaaaaa actttttata gaaagctcat aaataatcat gtcattttgc     4440

aattttgtta ccaaaatttc ccccaagagt tttcaaatat tagttctgca atgtggctat     4500

gaaatatgca ctgaaatata ccttttaatt tgagaaccag tggttagaat aagctgtgat     4560

ataaagtatt ttcagtgtac ttttaaagga actataaggc cctccagcat aaacgctaaa     4620

agaatagatg gtagcacagg ccatgagggc tgggggagag aagcagagtg aaccttagaa     4680

agatggctca gctatttgga gcactggata ttttactgaa gttatttact gaggcaccat     4740

cactgttttg actgtacagt atagtttttc ataaatttca tcacatttac tttgttcaga     4800

atctgggctt gaatctttga gttggacaaa agcctatggt ttcttttaaa aagtttcatc     4860

ttgagctaat gctacagttt aaataaaatg tatgaaaggt agttatcaaa aacaatttgt     4920

atatttaaaa ttctattttg acatccattt tttacagcga attatagcag gttatgtgaa     4980

atttaaaaat aaattttagg aaattttttt atcttgtaag taagaattat aaatctatct     5040

cagttaaaag taggatcttt gtttttattc agatattttg aaagtttaga agcattttgt     5100

atgctacttt ggtatttctt aagtatagtc agcaggaaag ggtaacctgt tttatgcaaa     5160

atttttttaa tttgtcaaat gtttttagtg tgtctacttt ctgaaatagt ctcaatatcc     5220

tgtctgtatc ctaggcagat aactacacaa gaacaaaacg ctatatagaa aagaaaatat     5280

ttgaggaaat cttaaattcc ataagaaagt aattcttgca agaatgttgg ctacatattt     5340

ttttttctgt cctgaataaa ttacatcatt aggtctgttg aagcttttga agctaccact     5400

attctttctg ggataaaggc taattactga tttatctgcc ctcaaaatcc cagagttaat     5460

tctaattgag tactaaatta acagtaagta gttaacacag agaactaaaa tttaaccgca     5520

ttatatcact gtatatattt ctcatgattt ttgctaatta gagcatttac ttaaccagta     5580

ataaactaca cacacacaca cacacacaca cacgtatacg tgtgtgtgtg tatatacttg     5640

gctctgacac aactctggtg cttaattagg atatgttcta ttatgtattt tgaatgttta     5700

tcctgctagt gtgatgaact tttgttggaa aagcagaatt agaaggaaca gtttttcaat     5760

cagtttcatt tggtaattac aggaaaacct tgagttgctc taatttaatt tttccaatta     5820

atacatttag actttaaatt gcatccgtaa ttctcttggc tgaaaaacag tggtatttta     5880

agacagtttt gttatacatg tgacttactt ttgactcagc ctgagaggag gaaatgtaaa     5940

gagataagag atttggccca aagcagcaag agactagtaa ccttgagcca ggacgaagcc     6000

aagacaacgt gactcccaag tagcaggagc agaggtcggt cacctgtggc attctgtttc     6060

attccctttt aaaattatga gactttatag gcagtgtaaa acatcagcag gcagcgatgt     6120

gataggatgt gcgaaaaagc tggtctgata ccatggctat aattacagag ctttagttca     6180

attaggattt tgtaaatgag caaatgacct ttttttccag tgccccttgt aatagttaat     6240

atgagtccat gcaatcttgt gatgccattc tcctgaaggt gttgatttct ggtacccagc     6300

cagcttagct ttggctgctg gaagcacagt aggtactgat gattacttcc tggaaatctt     6360

gacaggctta ttgtactgtg taatggggaa aagttaaagt ataatgtttg gtgttaataa     6420

atgactgatg tgaaaatagg aacatgtgtc tttaatatca aatatggctt tatttgcagt     6480

gaaatctaaa ttccttattc tacagtagta ttttcttgcc ctgtgttgta tattttccta     6540

aatacatttt tcctgacagt ggctttaggc cagttgaaca cacttagact gaaagtgttt     6600

aacttaaaga gatcagtcca gaaaccatga taaattagaa tctttatctg gaattaccaa     6660

attaaaattt aaaatcatgg tccagaagag aacaaacatt catggttttt tttatcctac     6720

tgctcatttt taggtctgtg tttacatcta gtctctacta tttgtgaagt atgtcattat     6780

ttttttcaag ttcttctttg acttaactga aaaataatat tccaaattct taatgtaaca     6840

tgaaaagaga aatacaattt ttgcttaaaa gacatttttt aaaaagcgtt caattcagta     6900

atcatttctg ttaatacagg aagttttttt ggcttgccag ttatatactg tgggtatttt     6960

ttaaaatgtg ctacccttgg gttgtctcat atcaccttgc gtaatcatgt attacaaagg     7020

ttgataattg tcatttctca gatgtctgta tgttacattg gcagcagtaa aatgttttaa     7080

tgttgttacc ttttaaataa ttgtgttgta ttaacatgcc tcatattttc tggggaaact     7140

tgaaatatat ctaaacaaaa aaggtctgtt ataaatagga attggcattt cattgttaat     7200

gttttttcct cataaaaata gttacaccaa aagtgacata ttgtctatta catgggccca     7260

atcagtatta aagtactccc cttactcaaa aatattaaaa aataattcat gacacttagt     7320

agcattttca ttgattgttt caaaagatct tcataatggt caaattgtcc aattcacaaa     7380

agagtgagaa agttgttttc agtactggga atttttaaac cttagtttta agaccaaaaa     7440

tatctcttat tagcttgaac attttgtgat tacttttccc tccccggatc tagtcctttt     7500

aaggagtaag tctaaagaat gaggccatga agtcactatt tcctcccacc tcagtttgtc     7560

tcctggtact tagctggcct atcgctttgt gtggcaatac ccctgggtcg cttccccact     7620

cagccttctg tatctgctgt tcacaggaca tgccattatg tctttccagt acggatcaca     7680

gtgctgccat atcacagacc ctgccagccg gcacagaacc atgcctcgtc acagctctgc     7740

ccaactcaca ggctgccaag atgaggccac aggtccacct agggcggcag atgctggtgc     7800

tatttgtcac gacttttgcc aaaacatgta cactgttgct cacatctttc gtaagaatgg     7860

ttgacactaa ggggccatgg aaaagcactt ttaaaaaatt atgtggtgga atcaaactca     7920

cagaggcaga aatgttagtg ccgtgctcta accaagtaag cttagtgttc cccacagtga     7980

tctgtatctg gcctgagtct cctcaagcag caacccccac tgtccagcat gtggaaggta     8040

gatccttatg acaacaccag acccatagtt accaggaaag aaaaaggaag ctgagtgttg     8100

tgaaggggaa gaaatccttt ttataagaag taatcatttt taggccgggt gcagtggctc     8160

atgcctgtaa tcccagcact ttgggaggct gagacaggtg gatcacttga ggtcaggagt     8220

ttgagacctg cctggccaac atgatgaaac cctgtctcta ctaaaaatgc aaaaaaaatt     8280

agccaggcat ggtggcatgt gcctgtagtc ccaactactc aggaggctga ggcaggagaa     8340

tcacttgaac ctgggaggca gaggttgcaa tgagctgaga tcgcaacact gcactccagc     8400

ctgggcgaca gagcaagact ccatctcaaa aacaaaaaca aaaaaaaaac ctttttaaag     8460

taaattgagt gtaaaatgtt ttcaccatga agccattgca ccctctcccc caggaaacag     8520

tgcctaagga tgatgtcaag ttacagccag tttgctctga tcccccagga cctaagaaaa     8580

ctgtgagtgc ttcagcatgc aaaggtagag ctaccagata aggagaataa cttggccatt     8640

tatagcaaac tgcctgactt tggagtgaga aaccaagcac cttctaggtc ctaggatagg     8700

tgaattggag gtgcagctgc tgaagttccc attttctaca tacttcagga gccagggtgt     8760

ttcatttggt tttgtaaaac tttgctgtaa gtcatcacag ttaattcttt gaatggacat     8820

tttagagtgt aacttttttt caaaattagc agaacagata tctctgctca ttctctttat     8880

acatttagtt ttttaaagtt cccctagtat acctgttagg cactctaaat aggacacagt     8940

taaagctaaa agaaggacca gttgctccct agagcctaca gttcagaact atcttgttgt     9000

catgtcctgg tttggtttgg tttgttttta actcaacaag ttggaaacca tgagtttaaa     9060

gcaaactatt tccttttctt aagcttaaag agaatttttt ttttaatctt tagctcctca     9120

tttaggtagt gaaggcttcc ctgaaagaca gcagtgccct tctctggaag aagaggctgg     9180

gaccaaaagc ctgagtctat gggttgagga ttttgagcat tcctttgaca agcttctatg     9240

tatttttaat ataagactca taaatgaacc tgatgtggtg ttcatgaccc atcccttaag     9300

catgcttgct ttttttaact ttactttttg agtatagtac ttgtcttgtt tttcctggag     9360

ccatgctagg atttaattcc tatgtgccac tacccgccca tgtcctggaa gatggccatg     9420

cctgcagcaa tgctcatgtc ttgaggagaa gcaatgtgaa aagcatcagg aaagctgaac     9480

cttacgttca agtcagcaaa catttgtgag cattctagta tgcttgcgac cttgacactt     9540

tttaaaaatt atctttttat ttgcttcgag tatcaaccgt atagttgact ctagtggggc     9600

gaagggagca gagatgagag caaaattcag acttgctgcc cctgtgtgtc tcagttctca     9660

tgtctctctg agaaatgtgt tggcccaatt ccctatctgc cactctgagt ctcttgagta     9720

aatgtgtgta aatgagaaaa attatctcaa agatttaact tattatttag atattttctt     9780

ctttttaaac tcaggaataa acctggtttg tagataatat aatatggcta ctagagctat     9840

aattgagtag gtgactagaa gcattttttc aaatatattt cttgtaaaga catctacttt     9900

gttttaacta ggaaaagaaa ctcctcatat taaaataaac atttccataa gcactttcta     9960

gaagagtgta gcatccatct accatccatc ccagaatgtt tgtatcttgc tcatagtatt    10020

tcaaaaattt ttatgggtga aaaaaatgca cttttttatt tattggaaaa gtgtagagtt    10080

attgaattaa attctcaagt gggacaattt agtgtaaagg gaaacatggg ttttggagac    10140

aagagcacag ggctgtggtc cctgttccag cattgacttt actatgtgac ctcgagcaaa    10200

tgatttaact tctctgtgcc tcagtttctc catatacaaa atggggataa tgatactaac    10260

cattgcctac ctcatagaga tgttatgggg acaaacgaaa taatagagat aagcacgaat    10320

gctttcaact cttcggaaga aaggtgctat ataaattgaa gttgtgtttt taatgatcca    10380

attattaatt atgtttaggg tttaaataac aatactgtta gtcatgttaa gaataagttt    10440

tgttttgatg catatttcca cttctcttct gtggccagat cttgatcatt caaccagtaa    10500

tggtacctga ggaactgaaa tgggtatttg ttttcgtatg tttctgccag tagtatttca    10560

attgaatatc cagaaaagac tggagtttaa cttgtaatat cttatagttt acatgtaata    10620

aaacttattc aagctatata taaaagtatg attacatgta aatagcaggt atgttgtaat    10680

taaaggcact tatcaaattg tctttgttct tttttaattg taataaaagt cagttttaca    10740

taaa                                                                 10744


<210>  90
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Pro Ala Gly Ser Leu Leu Gly Ser Gly Gln Met Gln Ile Thr 
1               5                   10                  15      


Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe 
            20                  25                  30          


Leu Ile Phe Leu Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln 
        35                  40                  45              


His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu 
    50                  55                  60                  


Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser 
65                  70                  75                  80  


Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp 
                85                  90                  95      


Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala 
            100                 105                 110         


Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His 
        115                 120                 125             


Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr 
    130                 135                 140                 


Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu 
145                 150                 155                 160 


Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val 
                165                 170                 175     


Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala 
            180                 185                 190         


Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser 
        195                 200                 205             


Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe 
    210                 215                 220                 


Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val 
225                 230                 235                 240 


Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala 
                245                 250                 255     


Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln 
            260                 265                 270         


Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser 
        275                 280                 285             


Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu 
    290                 295                 300                 


Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val 
305                 310                 315                 320 


Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val 
                325                 330                 335     


Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro 
            340                 345                 350         


Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr 
        355                 360                 365             


Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu 
    370                 375                 380                 


Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala 
385                 390                 395                 400 


Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp 
                405                 410                 415     


Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
            420                 425                 430         


<210>  91
<211>  8240
<212>  DNA
<213>  Homo sapiens

<400>  91
cccctctcgg tagccctgag gctctggcgc cttcaagtga gaagctaagc accagcctct       60

gctgggctgc agaagcggcg gcggcggcag cagcagcagc agcatcagga aggcgctcgg      120

gccagcgcgg tgaacccggg ctgggcagca ggtcgcggag ccgcgagcca ggatggaggc      180

agagggcagc agcgcgccgg cccgggcggg cagcggagag ggcagcgaca gcgccggcgg      240

ggccacgctc aaagccccca agcatctctg gaggcacgag cagcaccacc agtacccgct      300

ccggcagccc cagttccgcc tcctgcatcc ccatcaccac ctgcccccgc cgccgccacc      360

ctcgccccag ccccagcccc agtgtccgct acagccgccg ccgccgcccc ccctgccgcc      420

gcccccgccg ccgcccgggg ctgcccgcgg ccgctacgcc tcgagcgggg ccaccggccg      480

cgtccggcat cgcggctact cggacaccga gcgctacctg tactgtcgcg ccatggaccg      540

cacctcctac gcggtggaga ccggccaccg gcccggcctg aagaaatcca ggatgtcctg      600

gccctcctcg ttccagggac tcaggcgttt tgatgtggac aatggcacat ctgcgggacg      660

gagtcccttg gatcccatga ccagcccagg atccgggcta attctccaag caaattttgt      720

ccacagtcaa cgacgggagt ccttcctgta tcgatccgac agcgattatg acctctctcc      780

aaagtctatg tcccggaact cctccattgc cagtgatata cacggagatg acttgattgt      840

gactccattt gctcaggtct tggccagtct gcgaactgta cgaaacaact ttgctgcatt      900

aactaatttg caagatcgag cacctagcaa aagatcaccc atgtgcaacc aaccatccat      960

caacaaagcc accataacag aggaggccta ccagaaactg gccagcgaga ccctggagga     1020

gctggactgg tgtctggacc agctagagac cctacagacc aggcactccg tcagtgagat     1080

ggcctccaac aagtttaaaa ggatgcttaa tcgggagctc acccatctct ctgaaatgag     1140

tcggtctgga aatcaagtgt cagagtttat atcaaacaca ttcttagata agcaacatga     1200

agtggaaatt ccttctccaa ctcagaagga aaaggagaaa aagaaaagac caatgtctca     1260

gatcagtgga gtcaagaaat tgatgcacag ctctagtctg actaattcaa gtatcccaag     1320

gtttggagtt aaaactgaac aagaagatgt ccttgccaag gaactagaag atgtgaacaa     1380

atggggtctt catgttttca gaatagcaga gttgtctggt aaccggccct tgactgttat     1440

catgcacacc atttttcagg aacgggattt attaaaaaca tttaaaattc cagtagatac     1500

tttaattaca tatcttatga ctctcgaaga ccattaccat gctgatgtgg cctatcacaa     1560

caatatccat gctgcagatg ttgtccagtc tactcatgtg ctattatcta cacctgcttt     1620

ggaggctgtg tttacagatt tggagattct tgcagcaatt tttgccagtg caatacatga     1680

tgtagatcat cctggtgtgt ccaatcaatt tctgatcaat acaaactctg aacttgcctt     1740

gatgtacaat gattcctcag tcttagagaa ccatcatttg gctgtgggct ttaaattgct     1800

tcaggaagaa aactgtgaca ttttccagaa tttgaccaaa aaacaaagac aatctttaag     1860

gaaaatggtc attgacatcg tacttgcaac agatatgtca aaacacatga atctactggc     1920

tgatttgaag actatggttg aaactaagaa agtgacaagc tctggagttc ttcttcttga     1980

taattattcc gataggattc aggttcttca gaatatggtg cactgtgcag atctgagcaa     2040

cccaacaaag cctctccagc tgtaccgcca gtggacggac cggataatgg aggagttctt     2100

ccgccaagga gaccgagaga gggaacgtgg catggagata agccccatgt gtgacaagca     2160

caatgcttcc gtggaaaaat cacaggtggg cttcatagac tatattgttc atcccctctg     2220

ggagacatgg gcagacctcg tccaccctga cgcccaggat attttggaca ctttggagga     2280

caatcgtgaa tggtaccaga gcacaatccc tcagagcccc tctcctgcac ctgatgaccc     2340

agaggagggc cggcagggtc aaactgagaa attccagttt gaactaactt tagaggaaga     2400

tggtgagtca gacacggaaa aggacagtgg cagtcaagtg gaagaagaca ctagctgcag     2460

tgactccaag actctttgta ctcaagactc agagtctact gaaattcccc ttgatgaaca     2520

ggttgaagag gaggcagtag gggaagaaga ggaaagccag cctgaagcct gtgtcataga     2580

tgatcgttct cctgacacgt aacagtgcaa aaactttcat gccttttttt tttttaagta     2640

gaaaaattgt ttccaaagtg catgtcacat gccacaacca cggtcacacc tcactgtcat     2700

ctgccaggac gtttgttgaa caaaactgac cttgactact cagtccagcg ctcaggaata     2760

tcgtaaccag ttttttcacc tccatgtcat ccgagcaagg tggacatctt cacgaacagc     2820

gtttttaaca agatttcagc ttggtagagc tgacaaagca gataaaatct actccaaatt     2880

attttcaaga gagtgtgact catcaggcag cccaaaagtt tattggactt ggggtttcta     2940

ttccttttta tttgtttgca atattttcag aagaaaggca ttgcacagag tgaacttaat     3000

ggacgaagca acaaatatgt caagaacagg acatagcacg aatctgttac cagtaggagg     3060

aggatgagcc acagaaattg cataattttc taatttcaag tcttcctgat acatgactga     3120

atagtgtggt tcagtgagct gcactgacct ctacattttg tatgatatgt aaaacagatt     3180

ttttgtagag cttactttta ttattaaatg tattgaggta ttatatttaa aaaaaactat     3240

gttcagaact tcatctgcca ctggttattt ttttctaagg agtaacttgc aagttttcag     3300

tacaaatctg tgctacactg gataaaaatc taatttatga attttacttg caccttatag     3360

ttcatagcaa ttaactgatt tgtagtgatt cattgtttgt tttatatacc aatgacttcc     3420

atattttaaa agagaaaaac aactttatgt tgcaggaaac cctttttgta agtctttatt     3480

atttactttg cattttgttt cactctttcc agataagcag agttgctctt caccagtgtt     3540

tttcttcatg tgcaaagtga ctatttgttc tataatactt ttatgtgtgt tatatcaaat     3600

gtgtcttaag cttcatgcaa actcagtcat cagttcgtgt tgtctgaagc aagtgggaga     3660

tatataaata cccagtagct aaaatggtca gtctttttta gatgttttcc tacttagtat     3720

ctcctaataa cgttttgctg tgtcactaga tgttcatttc acaagtgcat gtctttctaa     3780

taatccacac atttcatgct ctaataatcc acacatttca tgctcatttt tattgttttt     3840

acagccagtt atagtaagaa aaaggttttt ccccttgtgc tgctttataa tttagcgtgt     3900

gtctgaacct tatccatgtt tgctagatga ggtcttgtca aatatatcac taccattgtc     3960

accggtgaaa agaaacaggt agttaagtta gggttaacat tcatttcaac cacgaggttg     4020

tatatcatga ctagctttta ctcttggttt acagagaaaa gttaaacagc caactaggca     4080

gtttttaaga atattaacaa tatattaaca aacaccaata caactaatcc tatttggttt     4140

taatgatttc accatgggat taagaactat atcaggaaca tccctgagaa acggttttaa     4200

gtgtagcaac tactcttcct taatggacag ccacataacg tgtaggaagt cctttatcac     4260

ttatcctcga tccataagca tatcttgcag aggggaacta cttctttaaa cacatggagg     4320

gaaagaagat gatgccactg gcaccagagg gttagtactg tgatgcatcc taaaatattt     4380

attatattgg taaaaattct ggttaaataa aaaattagag atcactcttg gctgatttca     4440

gcaccaggaa ctgtattaca gttttagaga ttaattccta gtgtttacct gattatagca     4500

gttggcatca tggggcattt aattctgact ttatccccac gtcagcctta ataaagtctt     4560

ctttaccttc tctatgaaga ctttaaagcc caaataatca tttttcacat tgatattcaa     4620

gaattgagat agatagaagc caaagtgggt atctgacaag tggaaaatca aacgtttaag     4680

aagaattaca actctgaaaa gcatttatat gtggaacttc tcaaggagcc tcctggggac     4740

tggaaagtaa gtcatcagcc aggcaaatga ctcatgctga agagagtccc catttcagtc     4800

ccctgagatc tagctgatgc ttagatcctt tgaaataaaa attatgtctt tataactctg     4860

atcttttaca taaagcagaa gaggaatcaa ctagttaatt gcaaggtttc tactctgttt     4920

cctctgtaaa gatcagatgg taatctttca aataagaaaa aaataaagac gtatgtttga     4980

ccaagtagtt tcacaagaat atttgggaac ttgtttcttt taattttatt tgtccctgag     5040

tgaagtctag aaagaaaggt aaagagtcta gagtttattc ctctttccaa aacattctca     5100

ttcctctcct ccctacactt agtatttccc ccacagagtg cctagaatct taataatgaa     5160

taaaataaaa agcagcaata tgtcattaac aaatccagac ctgaaagggt aaagggttta     5220

taactgcact aataaagaga ggctcttttt ttttcttcca gtttgttggt ttttaatggt     5280

accgtgttgt aaagataccc actaatggac aatcaaattg cagaaaaggc tcaatatcca     5340

agagacaggg actaatgcac tgtacaatct gcttatcctt gcccttctct cttgccaaag     5400

tgtgcttcag aaatatatac tgctttaaaa aagaataaaa gaatatcctt ttacaagtgg     5460

ctttacattt cctaaaatgc cataagaaaa tgcaatatct gggtactgta tggggaaaaa     5520

aatgtccaag tttgtgtaaa accagtgcat ttcagcttgc aagttactga acacaataat     5580

gctgttttaa ttttgtttta tatcagttaa aattcacaat aatgtagata gaacaaatta     5640

cagacaagga aagaaaaaac ttgaatgaaa tggattttac agaaagcttt atgataattt     5700

ttgaatgcat tatttatttt ttgtgccatg catttttttt ctcaccaaat gaccttacct     5760

gtaatacagt cttgtttgtc tgtttacaac catgtattta ttgcaatgta catactgtaa     5820

tgttaattgt aaattatctg ttcttattaa aacatcatcc catgatggga tggtgttgat     5880

atatttggaa actcttggtg agagaatgaa tggtgtgtat acatactctg tacatttttc     5940

ttttctcctg taatatagtc ttgtcacctt agagcttgtt tatggaagat tcaagaaaac     6000

tataaaatac ttaaagatat ataaatttaa aaaaacatag ctgcaggtct ttggtcccag     6060

ggctgtgcct taactttaac caatattttc ttctgttttg ctgcatttga aaggtaacag     6120

tggagctagg gctgggcatt ttacatccag gcttttaatt gattagaatt ctgccaatag     6180

gtggatttta caaaaccaca gacaacctct gaaagattct gagacccttt tgagacagaa     6240

gctcttaagt acttcttgcc agggagcagc actgcatgtg tgatggttgt ttgccatctg     6300

ttgatcagga actacttcag ctacttgcat ttgattattt cctttttttt tttttttaac     6360

tcggaaacac aactggggaa atatattctt tcccagtgat tataaacaat ctttttcttt     6420

tttttaagtc cttttggctt ctagagctca taggaaaatg gacttgattt gaaattggag     6480

ccagagttta ctcgtgttgg ttatctattc atcagcttcc tgacatgtta agagaataca     6540

ttaaagagaa aatactgttt tttaatccta aaatttttct tccactaaga taaaccaaat     6600

gtccttacat atatgtaaac ccatctattt aaacgcaaag gtgggttgat gtcagtttac     6660

atagcagaaa gcattcacta tcctctaaga tttgtttctg caaaactttc attgctttag     6720

aattttaaaa tttcaccttg tacaatggcc agcccctaaa gcaggaaaca tttataatgg     6780

attatatgga aacatcctcc cagtacttgc ccagcccttg aatcatgtgg cttttcagtg     6840

aaaggaaaga ttctttttct aggaaaaatg agcctatttt attttatttt attttatttt     6900

ttgacacaaa ctgtagattt tagcagccct ggcccaaagg aatttgatta cttttgtttt     6960

aaacagtaca aaggggacac tataattaca aaaacatcct taactgattt gagttgtttt     7020

tatttctttg gatatatttt cagagtggta aattgtgtgt gagaattaca aatgattatt     7080

cttttagtgg tttcttagcc tctcttacag cccacgggga tagtactgta catcaatacc     7140

ttcatatgaa atttttatat gcaatgaaaa taaaagcatg ggttgattct gcctatttat     7200

gactcaatct tttacaaata aaagattatt cattttaaat tatagttcaa tcagcatgtc     7260

tcttaggata ctgaacgtgg ttgaaatgaa aggatagtga catcataagt tagtactgat     7320

attcataacc aaataaagcc aacttgagta attttgctac attaaaaatt accaaaatta     7380

cttagatggc ctataagatt aagcatggtg ttttctaagc aagctttgaa aggggccttc     7440

catacttact taattgaata ttctgggata ttgaaaatta ttcagatact tgacaattat     7500

ttttggttac ctactccgca aactacaaag ttttaaggac tcaacaataa gttaatgaga     7560

cacagtgttt gctttcatgg agcttacagt ctggagggga caaaggctta aacaatactc     7620

atataattat atatgtgatc agtacaatga aggagctcag tggggtaaat aagcaggaac     7680

ctgaacttga tctgttccgg agggccacag aaggcttcct tgaggccttg agaaagtgat     7740

ttgcatctga gttctgaagg attgtaagag gtaactaggg aaaaagttga caggaagagg     7800

aaggggatcc agacaagaaa catttgcaaa gatcttgagg cataaatgag cttgagacat     7860

ctggagaaac tgaggaaaag tgagagagta ggcagggcct ggagccgcag agccattgct     7920

aaccatcctg tgtgagatat cccccattct gtagctttat tctcataacc ctgctcaatt     7980

ttctttataa cacttctcac agatttatat acgtgtttgt ttttgttatc tgtctctccc     8040

accagaccac agctccatga gagcaaggtc tttgcttacc aatatatcac tagcacttaa     8100

aactatgcct ggtacacagt aggttcttaa tatgtgttga atatagccat caaattgata     8160

ttggatataa ttcaatctga taagatattt tgagatatta aagagttttt aacttgatac     8220

cataaaaaaa aaaaaaaaaa                                                 8240


<210>  92
<211>  8153
<212>  DNA
<213>  Homo sapiens

<400>  92
aatacttgtt gcaataattg cccacgatag ctgctcaaac aagagagttg gaattcatct       60

gtaaaaatca ctacatgtaa cgtaggagac aagaaaaata ttaatgacag aagatctgcg      120

aacatgatgc acgtgaataa ttttcccttt agaaggcatt cctggatatg ctgatggtaa      180

cagcagaaaa atgtgaactc tgaataaaga ggtgggagtt tttcagcaca taaagaatat      240

ttaaagccaa ttcattggat gcattgacca gtaagtgtag agatcaaaat caagaacaac      300

tccaagaatt gagagcagat gcaaacccca atttttgtgg gtctccagtc cagccttccc      360

aggaatgctg gtctgactac tcagatttgc ttttacttct tgccttttgg atataatgag      420

tttgccaagc agctgtgagt acctgactct ggggaaggtg gctagattcc gaagcgctta      480

tgttcatgga tcaccatacg cgatcaacat gccaattgat attaagccac agaggagacg      540

ttttgatgtg gacaatggca catctgcggg acggagtccc ttggatccca tgaccagccc      600

aggatccggg ctaattctcc aagcaaattt tgtccacagt caacgacggg agtccttcct      660

gtatcgatcc gacagcgatt atgacctctc tccaaagtct atgtcccgga actcctccat      720

tgccagtgat atacacggag atgacttgat tgtgactcca tttgctcagg tcttggccag      780

tctgcgaact gtacgaaaca actttgctgc attaactaat ttgcaagatc gagcacctag      840

caaaagatca cccatgtgca accaaccatc catcaacaaa gccaccataa cagaggaggc      900

ctaccagaaa ctggccagcg agaccctgga ggagctggac tggtgtctgg accagctaga      960

gaccctacag accaggcact ccgtcagtga gatggcctcc aacaagttta aaaggatgct     1020

taatcgggag ctcacccatc tctctgaaat gagtcggtct ggaaatcaag tgtcagagtt     1080

tatatcaaac acattcttag ataagcaaca tgaagtggaa attccttctc caactcagaa     1140

ggaaaaggag aaaaagaaaa gaccaatgtc tcagatcagt ggagtcaaga aattgatgca     1200

cagctctagt ctgactaatt caagtatccc aaggtttgga gttaaaactg aacaagaaga     1260

tgtccttgcc aaggaactag aagatgtgaa caaatggggt cttcatgttt tcagaatagc     1320

agagttgtct ggtaaccggc ccttgactgt tatcatgcac accatttttc aggaacggga     1380

tttattaaaa acatttaaaa ttccagtaga tactttaatt acatatctta tgactctcga     1440

agaccattac catgctgatg tggcctatca caacaatatc catgctgcag atgttgtcca     1500

gtctactcat gtgctattat ctacacctgc tttggaggct gtgtttacag atttggagat     1560

tcttgcagca atttttgcca gtgcaataca tgatgtagat catcctggtg tgtccaatca     1620

atttctgatc aatacaaact ctgaacttgc cttgatgtac aatgattcct cagtcttaga     1680

gaaccatcat ttggctgtgg gctttaaatt gcttcaggaa gaaaactgtg acattttcca     1740

gaatttgacc aaaaaacaaa gacaatcttt aaggaaaatg gtcattgaca tcgtacttgc     1800

aacagatatg tcaaaacaca tgaatctact ggctgatttg aagactatgg ttgaaactaa     1860

gaaagtgaca agctctggag ttcttcttct tgataattat tccgatagga ttcaggttct     1920

tcagaatatg gtgcactgtg cagatctgag caacccaaca aagcctctcc agctgtaccg     1980

ccagtggacg gaccggataa tggaggagtt cttccgccaa ggagaccgag agagggaacg     2040

tggcatggag ataagcccca tgtgtgacaa gcacaatgct tccgtggaaa aatcacaggt     2100

gggcttcata gactatattg ttcatcccct ctgggagaca tgggcagacc tcgtccaccc     2160

tgacgcccag gatattttgg acactttgga ggacaatcgt gaatggtacc agagcacaat     2220

ccctcagagc ccctctcctg cacctgatga cccagaggag ggccggcagg gtcaaactga     2280

gaaattccag tttgaactaa ctttagagga agatggtgag tcagacacgg aaaaggacag     2340

tggcagtcaa gtggaagaag acactagctg cagtgactcc aagactcttt gtactcaaga     2400

ctcagagtct actgaaattc cccttgatga acaggttgaa gaggaggcag taggggaaga     2460

agaggaaagc cagcctgaag cctgtgtcat agatgatcgt tctcctgaca cgtaacagtg     2520

caaaaacttt catgcctttt ttttttttaa gtagaaaaat tgtttccaaa gtgcatgtca     2580

catgccacaa ccacggtcac acctcactgt catctgccag gacgtttgtt gaacaaaact     2640

gaccttgact actcagtcca gcgctcagga atatcgtaac cagttttttc acctccatgt     2700

catccgagca aggtggacat cttcacgaac agcgttttta acaagatttc agcttggtag     2760

agctgacaaa gcagataaaa tctactccaa attattttca agagagtgtg actcatcagg     2820

cagcccaaaa gtttattgga cttggggttt ctattccttt ttatttgttt gcaatatttt     2880

cagaagaaag gcattgcaca gagtgaactt aatggacgaa gcaacaaata tgtcaagaac     2940

aggacatagc acgaatctgt taccagtagg aggaggatga gccacagaaa ttgcataatt     3000

ttctaatttc aagtcttcct gatacatgac tgaatagtgt ggttcagtga gctgcactga     3060

cctctacatt ttgtatgata tgtaaaacag attttttgta gagcttactt ttattattaa     3120

atgtattgag gtattatatt taaaaaaaac tatgttcaga acttcatctg ccactggtta     3180

tttttttcta aggagtaact tgcaagtttt cagtacaaat ctgtgctaca ctggataaaa     3240

atctaattta tgaattttac ttgcacctta tagttcatag caattaactg atttgtagtg     3300

attcattgtt tgttttatat accaatgact tccatatttt aaaagagaaa aacaacttta     3360

tgttgcagga aacccttttt gtaagtcttt attatttact ttgcattttg tttcactctt     3420

tccagataag cagagttgct cttcaccagt gtttttcttc atgtgcaaag tgactatttg     3480

ttctataata cttttatgtg tgttatatca aatgtgtctt aagcttcatg caaactcagt     3540

catcagttcg tgttgtctga agcaagtggg agatatataa atacccagta gctaaaatgg     3600

tcagtctttt ttagatgttt tcctacttag tatctcctaa taacgttttg ctgtgtcact     3660

agatgttcat ttcacaagtg catgtctttc taataatcca cacatttcat gctctaataa     3720

tccacacatt tcatgctcat ttttattgtt tttacagcca gttatagtaa gaaaaaggtt     3780

tttccccttg tgctgcttta taatttagcg tgtgtctgaa ccttatccat gtttgctaga     3840

tgaggtcttg tcaaatatat cactaccatt gtcaccggtg aaaagaaaca ggtagttaag     3900

ttagggttaa cattcatttc aaccacgagg ttgtatatca tgactagctt ttactcttgg     3960

tttacagaga aaagttaaac agccaactag gcagttttta agaatattaa caatatatta     4020

acaaacacca atacaactaa tcctatttgg ttttaatgat ttcaccatgg gattaagaac     4080

tatatcagga acatccctga gaaacggttt taagtgtagc aactactctt ccttaatgga     4140

cagccacata acgtgtagga agtcctttat cacttatcct cgatccataa gcatatcttg     4200

cagaggggaa ctacttcttt aaacacatgg agggaaagaa gatgatgcca ctggcaccag     4260

agggttagta ctgtgatgca tcctaaaata tttattatat tggtaaaaat tctggttaaa     4320

taaaaaatta gagatcactc ttggctgatt tcagcaccag gaactgtatt acagttttag     4380

agattaattc ctagtgttta cctgattata gcagttggca tcatggggca tttaattctg     4440

actttatccc cacgtcagcc ttaataaagt cttctttacc ttctctatga agactttaaa     4500

gcccaaataa tcatttttca cattgatatt caagaattga gatagataga agccaaagtg     4560

ggtatctgac aagtggaaaa tcaaacgttt aagaagaatt acaactctga aaagcattta     4620

tatgtggaac ttctcaagga gcctcctggg gactggaaag taagtcatca gccaggcaaa     4680

tgactcatgc tgaagagagt ccccatttca gtcccctgag atctagctga tgcttagatc     4740

ctttgaaata aaaattatgt ctttataact ctgatctttt acataaagca gaagaggaat     4800

caactagtta attgcaaggt ttctactctg tttcctctgt aaagatcaga tggtaatctt     4860

tcaaataaga aaaaaataaa gacgtatgtt tgaccaagta gtttcacaag aatatttggg     4920

aacttgtttc ttttaatttt atttgtccct gagtgaagtc tagaaagaaa ggtaaagagt     4980

ctagagttta ttcctctttc caaaacattc tcattcctct cctccctaca cttagtattt     5040

cccccacaga gtgcctagaa tcttaataat gaataaaata aaaagcagca atatgtcatt     5100

aacaaatcca gacctgaaag ggtaaagggt ttataactgc actaataaag agaggctctt     5160

tttttttctt ccagtttgtt ggtttttaat ggtaccgtgt tgtaaagata cccactaatg     5220

gacaatcaaa ttgcagaaaa ggctcaatat ccaagagaca gggactaatg cactgtacaa     5280

tctgcttatc cttgcccttc tctcttgcca aagtgtgctt cagaaatata tactgcttta     5340

aaaaagaata aaagaatatc cttttacaag tggctttaca tttcctaaaa tgccataaga     5400

aaatgcaata tctgggtact gtatggggaa aaaaatgtcc aagtttgtgt aaaaccagtg     5460

catttcagct tgcaagttac tgaacacaat aatgctgttt taattttgtt ttatatcagt     5520

taaaattcac aataatgtag atagaacaaa ttacagacaa ggaaagaaaa aacttgaatg     5580

aaatggattt tacagaaagc tttatgataa tttttgaatg cattatttat tttttgtgcc     5640

atgcattttt tttctcacca aatgacctta cctgtaatac agtcttgttt gtctgtttac     5700

aaccatgtat ttattgcaat gtacatactg taatgttaat tgtaaattat ctgttcttat     5760

taaaacatca tcccatgatg ggatggtgtt gatatatttg gaaactcttg gtgagagaat     5820

gaatggtgtg tatacatact ctgtacattt ttcttttctc ctgtaatata gtcttgtcac     5880

cttagagctt gtttatggaa gattcaagaa aactataaaa tacttaaaga tatataaatt     5940

taaaaaaaca tagctgcagg tctttggtcc cagggctgtg ccttaacttt aaccaatatt     6000

ttcttctgtt ttgctgcatt tgaaaggtaa cagtggagct agggctgggc attttacatc     6060

caggctttta attgattaga attctgccaa taggtggatt ttacaaaacc acagacaacc     6120

tctgaaagat tctgagaccc ttttgagaca gaagctctta agtacttctt gccagggagc     6180

agcactgcat gtgtgatggt tgtttgccat ctgttgatca ggaactactt cagctacttg     6240

catttgatta tttccttttt tttttttttt aactcggaaa cacaactggg gaaatatatt     6300

ctttcccagt gattataaac aatctttttc ttttttttaa gtccttttgg cttctagagc     6360

tcataggaaa atggacttga tttgaaattg gagccagagt ttactcgtgt tggttatcta     6420

ttcatcagct tcctgacatg ttaagagaat acattaaaga gaaaatactg ttttttaatc     6480

ctaaaatttt tcttccacta agataaacca aatgtcctta catatatgta aacccatcta     6540

tttaaacgca aaggtgggtt gatgtcagtt tacatagcag aaagcattca ctatcctcta     6600

agatttgttt ctgcaaaact ttcattgctt tagaatttta aaatttcacc ttgtacaatg     6660

gccagcccct aaagcaggaa acatttataa tggattatat ggaaacatcc tcccagtact     6720

tgcccagccc ttgaatcatg tggcttttca gtgaaaggaa agattctttt tctaggaaaa     6780

atgagcctat tttattttat tttattttat tttttgacac aaactgtaga ttttagcagc     6840

cctggcccaa aggaatttga ttacttttgt tttaaacagt acaaagggga cactataatt     6900

acaaaaacat ccttaactga tttgagttgt ttttatttct ttggatatat tttcagagtg     6960

gtaaattgtg tgtgagaatt acaaatgatt attcttttag tggtttctta gcctctctta     7020

cagcccacgg ggatagtact gtacatcaat accttcatat gaaattttta tatgcaatga     7080

aaataaaagc atgggttgat tctgcctatt tatgactcaa tcttttacaa ataaaagatt     7140

attcatttta aattatagtt caatcagcat gtctcttagg atactgaacg tggttgaaat     7200

gaaaggatag tgacatcata agttagtact gatattcata accaaataaa gccaacttga     7260

gtaattttgc tacattaaaa attaccaaaa ttacttagat ggcctataag attaagcatg     7320

gtgttttcta agcaagcttt gaaaggggcc ttccatactt acttaattga atattctggg     7380

atattgaaaa ttattcagat acttgacaat tatttttggt tacctactcc gcaaactaca     7440

aagttttaag gactcaacaa taagttaatg agacacagtg tttgctttca tggagcttac     7500

agtctggagg ggacaaaggc ttaaacaata ctcatataat tatatatgtg atcagtacaa     7560

tgaaggagct cagtggggta aataagcagg aacctgaact tgatctgttc cggagggcca     7620

cagaaggctt ccttgaggcc ttgagaaagt gatttgcatc tgagttctga aggattgtaa     7680

gaggtaacta gggaaaaagt tgacaggaag aggaagggga tccagacaag aaacatttgc     7740

aaagatcttg aggcataaat gagcttgaga catctggaga aactgaggaa aagtgagaga     7800

gtaggcaggg cctggagccg cagagccatt gctaaccatc ctgtgtgaga tatcccccat     7860

tctgtagctt tattctcata accctgctca attttcttta taacacttct cacagattta     7920

tatacgtgtt tgtttttgtt atctgtctct cccaccagac cacagctcca tgagagcaag     7980

gtctttgctt accaatatat cactagcact taaaactatg cctggtacac agtaggttct     8040

taatatgtgt tgaatatagc catcaaattg atattggata taattcaatc tgataagata     8100

ttttgagata ttaaagagtt tttaacttga taccataaaa aaaaaaaaaa aaa            8153


<210>  93
<211>  8203
<212>  DNA
<213>  Homo sapiens

<400>  93
gcggcgcatt agttccaata gtttaacagg ctgctttgta gcacggacaa agccgtgcga       60

gcgcggtgct ttccctcctt gttcatttgc tatgcgagct tgtcagtgat ctttggcagg      120

ggcttgggag aggaggggtg acgtttaata cgcttccgcg gaggagtgcg ctcgcctcct      180

ctgcacccag ccccaggctc tacagagaga ctgaggcagg cgactgaatg cactaacagc      240

agcaggctca gacctgcttc cctggacatt tccgggaccg tgagcgaggg aaccacgttg      300

ccctggattc ttgccagctg tacaaagttg accaggaaaa tggctcagca gacaagcccg      360

gacactttaa cagtacctga agtggataat ccgcattgtc caaacccgtg gctgaacgaa      420

gaccttgtga aatccttgcg agaaaacctg ttgcagcatg agaagtccaa gacagcgagg      480

aaatcggttt ctcccaagct ctctccagtg atctctccga gaaattcccc caggcttctg      540

cgcagaatgc ttctcagcag caacatcccc aaacagcggc gtttcacggt ggcacataca      600

tgttttgatg tggacaatgg cacatctgcg ggacggagtc ccttggatcc catgaccagc      660

ccaggatccg ggctaattct ccaagcaaat tttgtccaca gtcaacgacg ggagtccttc      720

ctgtatcgat ccgacagcga ttatgacctc tctccaaagt ctatgtcccg gaactcctcc      780

attgccagtg atatacacgg agatgacttg attgtgactc catttgctca ggtcttggcc      840

agtctgcgaa ctgtacgaaa caactttgct gcattaacta atttgcaaga tcgagcacct      900

agcaaaagat cacccatgtg caaccaacca tccatcaaca aagccaccat aacagaggag      960

gcctaccaga aactggccag cgagaccctg gaggagctgg actggtgtct ggaccagcta     1020

gagaccctac agaccaggca ctccgtcagt gagatggcct ccaacaagtt taaaaggatg     1080

cttaatcggg agctcaccca tctctctgaa atgagtcggt ctggaaatca agtgtcagag     1140

tttatatcaa acacattctt agataagcaa catgaagtgg aaattccttc tccaactcag     1200

aaggaaaagg agaaaaagaa aagaccaatg tctcagatca gtggagtcaa gaaattgatg     1260

cacagctcta gtctgactaa ttcaagtatc ccaaggtttg gagttaaaac tgaacaagaa     1320

gatgtccttg ccaaggaact agaagatgtg aacaaatggg gtcttcatgt tttcagaata     1380

gcagagttgt ctggtaaccg gcccttgact gttatcatgc acaccatttt tcaggaacgg     1440

gatttattaa aaacatttaa aattccagta gatactttaa ttacatatct tatgactctc     1500

gaagaccatt accatgctga tgtggcctat cacaacaata tccatgctgc agatgttgtc     1560

cagtctactc atgtgctatt atctacacct gctttggagg ctgtgtttac agatttggag     1620

attcttgcag caatttttgc cagtgcaata catgatgtag atcatcctgg tgtgtccaat     1680

caatttctga tcaatacaaa ctctgaactt gccttgatgt acaatgattc ctcagtctta     1740

gagaaccatc atttggctgt gggctttaaa ttgcttcagg aagaaaactg tgacattttc     1800

cagaatttga ccaaaaaaca aagacaatct ttaaggaaaa tggtcattga catcgtactt     1860

gcaacagata tgtcaaaaca catgaatcta ctggctgatt tgaagactat ggttgaaact     1920

aagaaagtga caagctctgg agttcttctt cttgataatt attccgatag gattcaggtt     1980

cttcagaata tggtgcactg tgcagatctg agcaacccaa caaagcctct ccagctgtac     2040

cgccagtgga cggaccggat aatggaggag ttcttccgcc aaggagaccg agagagggaa     2100

cgtggcatgg agataagccc catgtgtgac aagcacaatg cttccgtgga aaaatcacag     2160

gtgggcttca tagactatat tgttcatccc ctctgggaga catgggcaga cctcgtccac     2220

cctgacgccc aggatatttt ggacactttg gaggacaatc gtgaatggta ccagagcaca     2280

atccctcaga gcccctctcc tgcacctgat gacccagagg agggccggca gggtcaaact     2340

gagaaattcc agtttgaact aactttagag gaagatggtg agtcagacac ggaaaaggac     2400

agtggcagtc aagtggaaga agacactagc tgcagtgact ccaagactct ttgtactcaa     2460

gactcagagt ctactgaaat tccccttgat gaacaggttg aagaggaggc agtaggggaa     2520

gaagaggaaa gccagcctga agcctgtgtc atagatgatc gttctcctga cacgtaacag     2580

tgcaaaaact ttcatgcctt tttttttttt aagtagaaaa attgtttcca aagtgcatgt     2640

cacatgccac aaccacggtc acacctcact gtcatctgcc aggacgtttg ttgaacaaaa     2700

ctgaccttga ctactcagtc cagcgctcag gaatatcgta accagttttt tcacctccat     2760

gtcatccgag caaggtggac atcttcacga acagcgtttt taacaagatt tcagcttggt     2820

agagctgaca aagcagataa aatctactcc aaattatttt caagagagtg tgactcatca     2880

ggcagcccaa aagtttattg gacttggggt ttctattcct ttttatttgt ttgcaatatt     2940

ttcagaagaa aggcattgca cagagtgaac ttaatggacg aagcaacaaa tatgtcaaga     3000

acaggacata gcacgaatct gttaccagta ggaggaggat gagccacaga aattgcataa     3060

ttttctaatt tcaagtcttc ctgatacatg actgaatagt gtggttcagt gagctgcact     3120

gacctctaca ttttgtatga tatgtaaaac agattttttg tagagcttac ttttattatt     3180

aaatgtattg aggtattata tttaaaaaaa actatgttca gaacttcatc tgccactggt     3240

tatttttttc taaggagtaa cttgcaagtt ttcagtacaa atctgtgcta cactggataa     3300

aaatctaatt tatgaatttt acttgcacct tatagttcat agcaattaac tgatttgtag     3360

tgattcattg tttgttttat ataccaatga cttccatatt ttaaaagaga aaaacaactt     3420

tatgttgcag gaaacccttt ttgtaagtct ttattattta ctttgcattt tgtttcactc     3480

tttccagata agcagagttg ctcttcacca gtgtttttct tcatgtgcaa agtgactatt     3540

tgttctataa tacttttatg tgtgttatat caaatgtgtc ttaagcttca tgcaaactca     3600

gtcatcagtt cgtgttgtct gaagcaagtg ggagatatat aaatacccag tagctaaaat     3660

ggtcagtctt ttttagatgt tttcctactt agtatctcct aataacgttt tgctgtgtca     3720

ctagatgttc atttcacaag tgcatgtctt tctaataatc cacacatttc atgctctaat     3780

aatccacaca tttcatgctc atttttattg tttttacagc cagttatagt aagaaaaagg     3840

tttttcccct tgtgctgctt tataatttag cgtgtgtctg aaccttatcc atgtttgcta     3900

gatgaggtct tgtcaaatat atcactacca ttgtcaccgg tgaaaagaaa caggtagtta     3960

agttagggtt aacattcatt tcaaccacga ggttgtatat catgactagc ttttactctt     4020

ggtttacaga gaaaagttaa acagccaact aggcagtttt taagaatatt aacaatatat     4080

taacaaacac caatacaact aatcctattt ggttttaatg atttcaccat gggattaaga     4140

actatatcag gaacatccct gagaaacggt tttaagtgta gcaactactc ttccttaatg     4200

gacagccaca taacgtgtag gaagtccttt atcacttatc ctcgatccat aagcatatct     4260

tgcagagggg aactacttct ttaaacacat ggagggaaag aagatgatgc cactggcacc     4320

agagggttag tactgtgatg catcctaaaa tatttattat attggtaaaa attctggtta     4380

aataaaaaat tagagatcac tcttggctga tttcagcacc aggaactgta ttacagtttt     4440

agagattaat tcctagtgtt tacctgatta tagcagttgg catcatgggg catttaattc     4500

tgactttatc cccacgtcag ccttaataaa gtcttcttta ccttctctat gaagacttta     4560

aagcccaaat aatcattttt cacattgata ttcaagaatt gagatagata gaagccaaag     4620

tgggtatctg acaagtggaa aatcaaacgt ttaagaagaa ttacaactct gaaaagcatt     4680

tatatgtgga acttctcaag gagcctcctg gggactggaa agtaagtcat cagccaggca     4740

aatgactcat gctgaagaga gtccccattt cagtcccctg agatctagct gatgcttaga     4800

tcctttgaaa taaaaattat gtctttataa ctctgatctt ttacataaag cagaagagga     4860

atcaactagt taattgcaag gtttctactc tgtttcctct gtaaagatca gatggtaatc     4920

tttcaaataa gaaaaaaata aagacgtatg tttgaccaag tagtttcaca agaatatttg     4980

ggaacttgtt tcttttaatt ttatttgtcc ctgagtgaag tctagaaaga aaggtaaaga     5040

gtctagagtt tattcctctt tccaaaacat tctcattcct ctcctcccta cacttagtat     5100

ttcccccaca gagtgcctag aatcttaata atgaataaaa taaaaagcag caatatgtca     5160

ttaacaaatc cagacctgaa agggtaaagg gtttataact gcactaataa agagaggctc     5220

tttttttttc ttccagtttg ttggttttta atggtaccgt gttgtaaaga tacccactaa     5280

tggacaatca aattgcagaa aaggctcaat atccaagaga cagggactaa tgcactgtac     5340

aatctgctta tccttgccct tctctcttgc caaagtgtgc ttcagaaata tatactgctt     5400

taaaaaagaa taaaagaata tccttttaca agtggcttta catttcctaa aatgccataa     5460

gaaaatgcaa tatctgggta ctgtatgggg aaaaaaatgt ccaagtttgt gtaaaaccag     5520

tgcatttcag cttgcaagtt actgaacaca ataatgctgt tttaattttg ttttatatca     5580

gttaaaattc acaataatgt agatagaaca aattacagac aaggaaagaa aaaacttgaa     5640

tgaaatggat tttacagaaa gctttatgat aatttttgaa tgcattattt attttttgtg     5700

ccatgcattt tttttctcac caaatgacct tacctgtaat acagtcttgt ttgtctgttt     5760

acaaccatgt atttattgca atgtacatac tgtaatgtta attgtaaatt atctgttctt     5820

attaaaacat catcccatga tgggatggtg ttgatatatt tggaaactct tggtgagaga     5880

atgaatggtg tgtatacata ctctgtacat ttttcttttc tcctgtaata tagtcttgtc     5940

accttagagc ttgtttatgg aagattcaag aaaactataa aatacttaaa gatatataaa     6000

tttaaaaaaa catagctgca ggtctttggt cccagggctg tgccttaact ttaaccaata     6060

ttttcttctg ttttgctgca tttgaaaggt aacagtggag ctagggctgg gcattttaca     6120

tccaggcttt taattgatta gaattctgcc aataggtgga ttttacaaaa ccacagacaa     6180

cctctgaaag attctgagac ccttttgaga cagaagctct taagtacttc ttgccaggga     6240

gcagcactgc atgtgtgatg gttgtttgcc atctgttgat caggaactac ttcagctact     6300

tgcatttgat tatttccttt tttttttttt ttaactcgga aacacaactg gggaaatata     6360

ttctttccca gtgattataa acaatctttt tctttttttt aagtcctttt ggcttctaga     6420

gctcatagga aaatggactt gatttgaaat tggagccaga gtttactcgt gttggttatc     6480

tattcatcag cttcctgaca tgttaagaga atacattaaa gagaaaatac tgttttttaa     6540

tcctaaaatt tttcttccac taagataaac caaatgtcct tacatatatg taaacccatc     6600

tatttaaacg caaaggtggg ttgatgtcag tttacatagc agaaagcatt cactatcctc     6660

taagatttgt ttctgcaaaa ctttcattgc tttagaattt taaaatttca ccttgtacaa     6720

tggccagccc ctaaagcagg aaacatttat aatggattat atggaaacat cctcccagta     6780

cttgcccagc ccttgaatca tgtggctttt cagtgaaagg aaagattctt tttctaggaa     6840

aaatgagcct attttatttt attttatttt attttttgac acaaactgta gattttagca     6900

gccctggccc aaaggaattt gattactttt gttttaaaca gtacaaaggg gacactataa     6960

ttacaaaaac atccttaact gatttgagtt gtttttattt ctttggatat attttcagag     7020

tggtaaattg tgtgtgagaa ttacaaatga ttattctttt agtggtttct tagcctctct     7080

tacagcccac ggggatagta ctgtacatca ataccttcat atgaaatttt tatatgcaat     7140

gaaaataaaa gcatgggttg attctgccta tttatgactc aatcttttac aaataaaaga     7200

ttattcattt taaattatag ttcaatcagc atgtctctta ggatactgaa cgtggttgaa     7260

atgaaaggat agtgacatca taagttagta ctgatattca taaccaaata aagccaactt     7320

gagtaatttt gctacattaa aaattaccaa aattacttag atggcctata agattaagca     7380

tggtgttttc taagcaagct ttgaaagggg ccttccatac ttacttaatt gaatattctg     7440

ggatattgaa aattattcag atacttgaca attatttttg gttacctact ccgcaaacta     7500

caaagtttta aggactcaac aataagttaa tgagacacag tgtttgcttt catggagctt     7560

acagtctgga ggggacaaag gcttaaacaa tactcatata attatatatg tgatcagtac     7620

aatgaaggag ctcagtgggg taaataagca ggaacctgaa cttgatctgt tccggagggc     7680

cacagaaggc ttccttgagg ccttgagaaa gtgatttgca tctgagttct gaaggattgt     7740

aagaggtaac tagggaaaaa gttgacagga agaggaaggg gatccagaca agaaacattt     7800

gcaaagatct tgaggcataa atgagcttga gacatctgga gaaactgagg aaaagtgaga     7860

gagtaggcag ggcctggagc cgcagagcca ttgctaacca tcctgtgtga gatatccccc     7920

attctgtagc tttattctca taaccctgct caattttctt tataacactt ctcacagatt     7980

tatatacgtg tttgtttttg ttatctgtct ctcccaccag accacagctc catgagagca     8040

aggtctttgc ttaccaatat atcactagca cttaaaacta tgcctggtac acagtaggtt     8100

cttaatatgt gttgaatata gccatcaaat tgatattgga tataattcaa tctgataaga     8160

tattttgaga tattaaagag tttttaactt gataccataa aaa                       8203


<210>  94
<211>  7783
<212>  DNA
<213>  Homo sapiens

<400>  94
aatacttgtt gcaataattg cccacgatag ctgctcaaac aagagagttg gaattcatct       60

gtaaaaatca ctacatgtaa cgtaggagac aagaaaaata ttaatgacag aagatctgcg      120

aacatgatgc acgtgaataa ttttcccttt agaaggcatt cctggatatg ttttgatgtg      180

gacaatggca catctgcggg acggagtccc ttggatccca tgaccagccc aggatccggg      240

ctaattctcc aagcaaattt tgtccacagt caacgacggg agtccttcct gtatcgatcc      300

gacagcgatt atgacctctc tccaaagtct atgtcccgga actcctccat tgccagtgat      360

atacacggag atgacttgat tgtgactcca tttgctcagg tcttggccag tctgcgaact      420

gtacgaaaca actttgctgc attaactaat ttgcaagatc gagcacctag caaaagatca      480

cccatgtgca accaaccatc catcaacaaa gccaccataa cagaggaggc ctaccagaaa      540

ctggccagcg agaccctgga ggagctggac tggtgtctgg accagctaga gaccctacag      600

accaggcact ccgtcagtga gatggcctcc aacaagttta aaaggatgct taatcgggag      660

ctcacccatc tctctgaaat gagtcggtct ggaaatcaag tgtcagagtt tatatcaaac      720

acattcttag ataagcaaca tgaagtggaa attccttctc caactcagaa ggaaaaggag      780

aaaaagaaaa gaccaatgtc tcagatcagt ggagtcaaga aattgatgca cagctctagt      840

ctgactaatt caagtatccc aaggtttgga gttaaaactg aacaagaaga tgtccttgcc      900

aaggaactag aagatgtgaa caaatggggt cttcatgttt tcagaatagc agagttgtct      960

ggtaaccggc ccttgactgt tatcatgcac accatttttc aggaacggga tttattaaaa     1020

acatttaaaa ttccagtaga tactttaatt acatatctta tgactctcga agaccattac     1080

catgctgatg tggcctatca caacaatatc catgctgcag atgttgtcca gtctactcat     1140

gtgctattat ctacacctgc tttggaggct gtgtttacag atttggagat tcttgcagca     1200

atttttgcca gtgcaataca tgatgtagat catcctggtg tgtccaatca atttctgatc     1260

aatacaaact ctgaacttgc cttgatgtac aatgattcct cagtcttaga gaaccatcat     1320

ttggctgtgg gctttaaatt gcttcaggaa gaaaactgtg acattttcca gaatttgacc     1380

aaaaaacaaa gacaatcttt aaggaaaatg gtcattgaca tcgtacttgc aacagatatg     1440

tcaaaacaca tgaatctact ggctgatttg aagactatgg ttgaaactaa gaaagtgaca     1500

agctctggag ttcttcttct tgataattat tccgatagga ttcaggttct tcagaatatg     1560

gtgcactgtg cagatctgag caacccaaca aagcctctcc agctgtaccg ccagtggacg     1620

gaccggataa tggaggagtt cttccgccaa ggagaccgag agagggaacg tggcatggag     1680

ataagcccca tgtgtgacaa gcacaatgct tccgtggaaa aatcacaggt gggcttcata     1740

gactatattg ttcatcccct ctgggagaca tgggcagacc tcgtccaccc tgacgcccag     1800

gatattttgg acactttgga ggacaatcgt gaatggtacc agagcacaat ccctcagagc     1860

ccctctcctg cacctgatga cccagaggag ggccggcagg gtcaaactga gaaattccag     1920

tttgaactaa ctttagagga agatggtgag tcagacacgg aaaaggacag tggcagtcaa     1980

gtggaagaag acactagctg cagtgactcc aagactcttt gtactcaaga ctcagagtct     2040

actgaaattc cccttgatga acaggttgaa gaggaggcag taggggaaga agaggaaagc     2100

cagcctgaag cctgtgtcat agatgatcgt tctcctgaca cgtaacagtg caaaaacttt     2160

catgcctttt ttttttttaa gtagaaaaat tgtttccaaa gtgcatgtca catgccacaa     2220

ccacggtcac acctcactgt catctgccag gacgtttgtt gaacaaaact gaccttgact     2280

actcagtcca gcgctcagga atatcgtaac cagttttttc acctccatgt catccgagca     2340

aggtggacat cttcacgaac agcgttttta acaagatttc agcttggtag agctgacaaa     2400

gcagataaaa tctactccaa attattttca agagagtgtg actcatcagg cagcccaaaa     2460

gtttattgga cttggggttt ctattccttt ttatttgttt gcaatatttt cagaagaaag     2520

gcattgcaca gagtgaactt aatggacgaa gcaacaaata tgtcaagaac aggacatagc     2580

acgaatctgt taccagtagg aggaggatga gccacagaaa ttgcataatt ttctaatttc     2640

aagtcttcct gatacatgac tgaatagtgt ggttcagtga gctgcactga cctctacatt     2700

ttgtatgata tgtaaaacag attttttgta gagcttactt ttattattaa atgtattgag     2760

gtattatatt taaaaaaaac tatgttcaga acttcatctg ccactggtta tttttttcta     2820

aggagtaact tgcaagtttt cagtacaaat ctgtgctaca ctggataaaa atctaattta     2880

tgaattttac ttgcacctta tagttcatag caattaactg atttgtagtg attcattgtt     2940

tgttttatat accaatgact tccatatttt aaaagagaaa aacaacttta tgttgcagga     3000

aacccttttt gtaagtcttt attatttact ttgcattttg tttcactctt tccagataag     3060

cagagttgct cttcaccagt gtttttcttc atgtgcaaag tgactatttg ttctataata     3120

cttttatgtg tgttatatca aatgtgtctt aagcttcatg caaactcagt catcagttcg     3180

tgttgtctga agcaagtggg agatatataa atacccagta gctaaaatgg tcagtctttt     3240

ttagatgttt tcctacttag tatctcctaa taacgttttg ctgtgtcact agatgttcat     3300

ttcacaagtg catgtctttc taataatcca cacatttcat gctctaataa tccacacatt     3360

tcatgctcat ttttattgtt tttacagcca gttatagtaa gaaaaaggtt tttccccttg     3420

tgctgcttta taatttagcg tgtgtctgaa ccttatccat gtttgctaga tgaggtcttg     3480

tcaaatatat cactaccatt gtcaccggtg aaaagaaaca ggtagttaag ttagggttaa     3540

cattcatttc aaccacgagg ttgtatatca tgactagctt ttactcttgg tttacagaga     3600

aaagttaaac agccaactag gcagttttta agaatattaa caatatatta acaaacacca     3660

atacaactaa tcctatttgg ttttaatgat ttcaccatgg gattaagaac tatatcagga     3720

acatccctga gaaacggttt taagtgtagc aactactctt ccttaatgga cagccacata     3780

acgtgtagga agtcctttat cacttatcct cgatccataa gcatatcttg cagaggggaa     3840

ctacttcttt aaacacatgg agggaaagaa gatgatgcca ctggcaccag agggttagta     3900

ctgtgatgca tcctaaaata tttattatat tggtaaaaat tctggttaaa taaaaaatta     3960

gagatcactc ttggctgatt tcagcaccag gaactgtatt acagttttag agattaattc     4020

ctagtgttta cctgattata gcagttggca tcatggggca tttaattctg actttatccc     4080

cacgtcagcc ttaataaagt cttctttacc ttctctatga agactttaaa gcccaaataa     4140

tcatttttca cattgatatt caagaattga gatagataga agccaaagtg ggtatctgac     4200

aagtggaaaa tcaaacgttt aagaagaatt acaactctga aaagcattta tatgtggaac     4260

ttctcaagga gcctcctggg gactggaaag taagtcatca gccaggcaaa tgactcatgc     4320

tgaagagagt ccccatttca gtcccctgag atctagctga tgcttagatc ctttgaaata     4380

aaaattatgt ctttataact ctgatctttt acataaagca gaagaggaat caactagtta     4440

attgcaaggt ttctactctg tttcctctgt aaagatcaga tggtaatctt tcaaataaga     4500

aaaaaataaa gacgtatgtt tgaccaagta gtttcacaag aatatttggg aacttgtttc     4560

ttttaatttt atttgtccct gagtgaagtc tagaaagaaa ggtaaagagt ctagagttta     4620

ttcctctttc caaaacattc tcattcctct cctccctaca cttagtattt cccccacaga     4680

gtgcctagaa tcttaataat gaataaaata aaaagcagca atatgtcatt aacaaatcca     4740

gacctgaaag ggtaaagggt ttataactgc actaataaag agaggctctt tttttttctt     4800

ccagtttgtt ggtttttaat ggtaccgtgt tgtaaagata cccactaatg gacaatcaaa     4860

ttgcagaaaa ggctcaatat ccaagagaca gggactaatg cactgtacaa tctgcttatc     4920

cttgcccttc tctcttgcca aagtgtgctt cagaaatata tactgcttta aaaaagaata     4980

aaagaatatc cttttacaag tggctttaca tttcctaaaa tgccataaga aaatgcaata     5040

tctgggtact gtatggggaa aaaaatgtcc aagtttgtgt aaaaccagtg catttcagct     5100

tgcaagttac tgaacacaat aatgctgttt taattttgtt ttatatcagt taaaattcac     5160

aataatgtag atagaacaaa ttacagacaa ggaaagaaaa aacttgaatg aaatggattt     5220

tacagaaagc tttatgataa tttttgaatg cattatttat tttttgtgcc atgcattttt     5280

tttctcacca aatgacctta cctgtaatac agtcttgttt gtctgtttac aaccatgtat     5340

ttattgcaat gtacatactg taatgttaat tgtaaattat ctgttcttat taaaacatca     5400

tcccatgatg ggatggtgtt gatatatttg gaaactcttg gtgagagaat gaatggtgtg     5460

tatacatact ctgtacattt ttcttttctc ctgtaatata gtcttgtcac cttagagctt     5520

gtttatggaa gattcaagaa aactataaaa tacttaaaga tatataaatt taaaaaaaca     5580

tagctgcagg tctttggtcc cagggctgtg ccttaacttt aaccaatatt ttcttctgtt     5640

ttgctgcatt tgaaaggtaa cagtggagct agggctgggc attttacatc caggctttta     5700

attgattaga attctgccaa taggtggatt ttacaaaacc acagacaacc tctgaaagat     5760

tctgagaccc ttttgagaca gaagctctta agtacttctt gccagggagc agcactgcat     5820

gtgtgatggt tgtttgccat ctgttgatca ggaactactt cagctacttg catttgatta     5880

tttccttttt tttttttttt aactcggaaa cacaactggg gaaatatatt ctttcccagt     5940

gattataaac aatctttttc ttttttttaa gtccttttgg cttctagagc tcataggaaa     6000

atggacttga tttgaaattg gagccagagt ttactcgtgt tggttatcta ttcatcagct     6060

tcctgacatg ttaagagaat acattaaaga gaaaatactg ttttttaatc ctaaaatttt     6120

tcttccacta agataaacca aatgtcctta catatatgta aacccatcta tttaaacgca     6180

aaggtgggtt gatgtcagtt tacatagcag aaagcattca ctatcctcta agatttgttt     6240

ctgcaaaact ttcattgctt tagaatttta aaatttcacc ttgtacaatg gccagcccct     6300

aaagcaggaa acatttataa tggattatat ggaaacatcc tcccagtact tgcccagccc     6360

ttgaatcatg tggcttttca gtgaaaggaa agattctttt tctaggaaaa atgagcctat     6420

tttattttat tttattttat tttttgacac aaactgtaga ttttagcagc cctggcccaa     6480

aggaatttga ttacttttgt tttaaacagt acaaagggga cactataatt acaaaaacat     6540

ccttaactga tttgagttgt ttttatttct ttggatatat tttcagagtg gtaaattgtg     6600

tgtgagaatt acaaatgatt attcttttag tggtttctta gcctctctta cagcccacgg     6660

ggatagtact gtacatcaat accttcatat gaaattttta tatgcaatga aaataaaagc     6720

atgggttgat tctgcctatt tatgactcaa tcttttacaa ataaaagatt attcatttta     6780

aattatagtt caatcagcat gtctcttagg atactgaacg tggttgaaat gaaaggatag     6840

tgacatcata agttagtact gatattcata accaaataaa gccaacttga gtaattttgc     6900

tacattaaaa attaccaaaa ttacttagat ggcctataag attaagcatg gtgttttcta     6960

agcaagcttt gaaaggggcc ttccatactt acttaattga atattctggg atattgaaaa     7020

ttattcagat acttgacaat tatttttggt tacctactcc gcaaactaca aagttttaag     7080

gactcaacaa taagttaatg agacacagtg tttgctttca tggagcttac agtctggagg     7140

ggacaaaggc ttaaacaata ctcatataat tatatatgtg atcagtacaa tgaaggagct     7200

cagtggggta aataagcagg aacctgaact tgatctgttc cggagggcca cagaaggctt     7260

ccttgaggcc ttgagaaagt gatttgcatc tgagttctga aggattgtaa gaggtaacta     7320

gggaaaaagt tgacaggaag aggaagggga tccagacaag aaacatttgc aaagatcttg     7380

aggcataaat gagcttgaga catctggaga aactgaggaa aagtgagaga gtaggcaggg     7440

cctggagccg cagagccatt gctaaccatc ctgtgtgaga tatcccccat tctgtagctt     7500

tattctcata accctgctca attttcttta taacacttct cacagattta tatacgtgtt     7560

tgtttttgtt atctgtctct cccaccagac cacagctcca tgagagcaag gtctttgctt     7620

accaatatat cactagcact taaaactatg cctggtacac agtaggttct taatatgtgt     7680

tgaatatagc catcaaattg atattggata taattcaatc tgataagata ttttgagata     7740

ttaaagagtt tttaacttga taccataaaa aaaaaaaaaa aaa                       7783


<210>  95
<211>  7667
<212>  DNA
<213>  Homo sapiens

<400>  95
acttcaagtg ccgtgcagaa ggctcggcag gcggggcggg cgtggggccg cggctccggg       60

ttggggaccg aggagatccg gctgtggacc agacgctcct ctgcggggcg ggcacccaag      120

cgcgctcgcc accccctcgc catccgctag agccgggctc ctggactggg actcgggccc      180

gccgcacagt tgaaaagtcg catagtggtt tttccgctcg cgtcgctgtg tgaaagttgg      240

ctcgccgctc tttgcacgcc ctccctggag gccgacccga gacgccaagc tggagagacc      300

gtgcctcccc gaggccggcc gccccgcgag cacagcctcc gcccccgttg cactgccggg      360

ctgggcaata tgaaggagca gccctcatgt gccggcaccg ggcatccgag catggcggga      420

ggaggcctac cagaaactgg ccagcgagac cctggaggag ctggactggt gtctggacca      480

gctagagacc ctacagacca ggcactccgt cagtgagatg gcctccaaca agtttaaaag      540

gatgcttaat cgggagctca cccatctctc tgaaatgagt cggtctggaa atcaagtgtc      600

agagtttata tcaaacacat tcttagataa gcaacatgaa gtggaaattc cttctccaac      660

tcagaaggaa aaggagaaaa agaaaagacc aatgtctcag atcagtggag tcaagaaatt      720

gatgcacagc tctagtctga ctaattcaag tatcccaagg tttggagtta aaactgaaca      780

agaagatgtc cttgccaagg aactagaaga tgtgaacaaa tggggtcttc atgttttcag      840

aatagcagag ttgtctggta accggccctt gactgttatc atgcacacca tttttcagga      900

acgggattta ttaaaaacat ttaaaattcc agtagatact ttaattacat atcttatgac      960

tctcgaagac cattaccatg ctgatgtggc ctatcacaac aatatccatg ctgcagatgt     1020

tgtccagtct actcatgtgc tattatctac acctgctttg gaggctgtgt ttacagattt     1080

ggagattctt gcagcaattt ttgccagtgc aatacatgat gtagatcatc ctggtgtgtc     1140

caatcaattt ctgatcaata caaactctga acttgccttg atgtacaatg attcctcagt     1200

cttagagaac catcatttgg ctgtgggctt taaattgctt caggaagaaa actgtgacat     1260

tttccagaat ttgaccaaaa aacaaagaca atctttaagg aaaatggtca ttgacatcgt     1320

acttgcaaca gatatgtcaa aacacatgaa tctactggct gatttgaaga ctatggttga     1380

aactaagaaa gtgacaagct ctggagttct tcttcttgat aattattccg ataggattca     1440

ggttcttcag aatatggtgc actgtgcaga tctgagcaac ccaacaaagc ctctccagct     1500

gtaccgccag tggacggacc ggataatgga ggagttcttc cgccaaggag accgagagag     1560

ggaacgtggc atggagataa gccccatgtg tgacaagcac aatgcttccg tggaaaaatc     1620

acaggtgggc ttcatagact atattgttca tcccctctgg gagacatggg cagacctcgt     1680

ccaccctgac gcccaggata ttttggacac tttggaggac aatcgtgaat ggtaccagag     1740

cacaatccct cagagcccct ctcctgcacc tgatgaccca gaggagggcc ggcagggtca     1800

aactgagaaa ttccagtttg aactaacttt agaggaagat ggtgagtcag acacggaaaa     1860

ggacagtggc agtcaagtgg aagaagacac tagctgcagt gactccaaga ctctttgtac     1920

tcaagactca gagtctactg aaattcccct tgatgaacag gttgaagagg aggcagtagg     1980

ggaagaagag gaaagccagc ctgaagcctg tgtcatagat gatcgttctc ctgacacgta     2040

acagtgcaaa aactttcatg cctttttttt ttttaagtag aaaaattgtt tccaaagtgc     2100

atgtcacatg ccacaaccac ggtcacacct cactgtcatc tgccaggacg tttgttgaac     2160

aaaactgacc ttgactactc agtccagcgc tcaggaatat cgtaaccagt tttttcacct     2220

ccatgtcatc cgagcaaggt ggacatcttc acgaacagcg tttttaacaa gatttcagct     2280

tggtagagct gacaaagcag ataaaatcta ctccaaatta ttttcaagag agtgtgactc     2340

atcaggcagc ccaaaagttt attggacttg gggtttctat tcctttttat ttgtttgcaa     2400

tattttcaga agaaaggcat tgcacagagt gaacttaatg gacgaagcaa caaatatgtc     2460

aagaacagga catagcacga atctgttacc agtaggagga ggatgagcca cagaaattgc     2520

ataattttct aatttcaagt cttcctgata catgactgaa tagtgtggtt cagtgagctg     2580

cactgacctc tacattttgt atgatatgta aaacagattt tttgtagagc ttacttttat     2640

tattaaatgt attgaggtat tatatttaaa aaaaactatg ttcagaactt catctgccac     2700

tggttatttt tttctaagga gtaacttgca agttttcagt acaaatctgt gctacactgg     2760

ataaaaatct aatttatgaa ttttacttgc accttatagt tcatagcaat taactgattt     2820

gtagtgattc attgtttgtt ttatatacca atgacttcca tattttaaaa gagaaaaaca     2880

actttatgtt gcaggaaacc ctttttgtaa gtctttatta tttactttgc attttgtttc     2940

actctttcca gataagcaga gttgctcttc accagtgttt ttcttcatgt gcaaagtgac     3000

tatttgttct ataatacttt tatgtgtgtt atatcaaatg tgtcttaagc ttcatgcaaa     3060

ctcagtcatc agttcgtgtt gtctgaagca agtgggagat atataaatac ccagtagcta     3120

aaatggtcag tcttttttag atgttttcct acttagtatc tcctaataac gttttgctgt     3180

gtcactagat gttcatttca caagtgcatg tctttctaat aatccacaca tttcatgctc     3240

taataatcca cacatttcat gctcattttt attgttttta cagccagtta tagtaagaaa     3300

aaggtttttc cccttgtgct gctttataat ttagcgtgtg tctgaacctt atccatgttt     3360

gctagatgag gtcttgtcaa atatatcact accattgtca ccggtgaaaa gaaacaggta     3420

gttaagttag ggttaacatt catttcaacc acgaggttgt atatcatgac tagcttttac     3480

tcttggttta cagagaaaag ttaaacagcc aactaggcag tttttaagaa tattaacaat     3540

atattaacaa acaccaatac aactaatcct atttggtttt aatgatttca ccatgggatt     3600

aagaactata tcaggaacat ccctgagaaa cggttttaag tgtagcaact actcttcctt     3660

aatggacagc cacataacgt gtaggaagtc ctttatcact tatcctcgat ccataagcat     3720

atcttgcaga ggggaactac ttctttaaac acatggaggg aaagaagatg atgccactgg     3780

caccagaggg ttagtactgt gatgcatcct aaaatattta ttatattggt aaaaattctg     3840

gttaaataaa aaattagaga tcactcttgg ctgatttcag caccaggaac tgtattacag     3900

ttttagagat taattcctag tgtttacctg attatagcag ttggcatcat ggggcattta     3960

attctgactt tatccccacg tcagccttaa taaagtcttc tttaccttct ctatgaagac     4020

tttaaagccc aaataatcat ttttcacatt gatattcaag aattgagata gatagaagcc     4080

aaagtgggta tctgacaagt ggaaaatcaa acgtttaaga agaattacaa ctctgaaaag     4140

catttatatg tggaacttct caaggagcct cctggggact ggaaagtaag tcatcagcca     4200

ggcaaatgac tcatgctgaa gagagtcccc atttcagtcc cctgagatct agctgatgct     4260

tagatccttt gaaataaaaa ttatgtcttt ataactctga tcttttacat aaagcagaag     4320

aggaatcaac tagttaattg caaggtttct actctgtttc ctctgtaaag atcagatggt     4380

aatctttcaa ataagaaaaa aataaagacg tatgtttgac caagtagttt cacaagaata     4440

tttgggaact tgtttctttt aattttattt gtccctgagt gaagtctaga aagaaaggta     4500

aagagtctag agtttattcc tctttccaaa acattctcat tcctctcctc cctacactta     4560

gtatttcccc cacagagtgc ctagaatctt aataatgaat aaaataaaaa gcagcaatat     4620

gtcattaaca aatccagacc tgaaagggta aagggtttat aactgcacta ataaagagag     4680

gctctttttt tttcttccag tttgttggtt tttaatggta ccgtgttgta aagataccca     4740

ctaatggaca atcaaattgc agaaaaggct caatatccaa gagacaggga ctaatgcact     4800

gtacaatctg cttatccttg cccttctctc ttgccaaagt gtgcttcaga aatatatact     4860

gctttaaaaa agaataaaag aatatccttt tacaagtggc tttacatttc ctaaaatgcc     4920

ataagaaaat gcaatatctg ggtactgtat ggggaaaaaa atgtccaagt ttgtgtaaaa     4980

ccagtgcatt tcagcttgca agttactgaa cacaataatg ctgttttaat tttgttttat     5040

atcagttaaa attcacaata atgtagatag aacaaattac agacaaggaa agaaaaaact     5100

tgaatgaaat ggattttaca gaaagcttta tgataatttt tgaatgcatt atttattttt     5160

tgtgccatgc attttttttc tcaccaaatg accttacctg taatacagtc ttgtttgtct     5220

gtttacaacc atgtatttat tgcaatgtac atactgtaat gttaattgta aattatctgt     5280

tcttattaaa acatcatccc atgatgggat ggtgttgata tatttggaaa ctcttggtga     5340

gagaatgaat ggtgtgtata catactctgt acatttttct tttctcctgt aatatagtct     5400

tgtcacctta gagcttgttt atggaagatt caagaaaact ataaaatact taaagatata     5460

taaatttaaa aaaacatagc tgcaggtctt tggtcccagg gctgtgcctt aactttaacc     5520

aatattttct tctgttttgc tgcatttgaa aggtaacagt ggagctaggg ctgggcattt     5580

tacatccagg cttttaattg attagaattc tgccaatagg tggattttac aaaaccacag     5640

acaacctctg aaagattctg agaccctttt gagacagaag ctcttaagta cttcttgcca     5700

gggagcagca ctgcatgtgt gatggttgtt tgccatctgt tgatcaggaa ctacttcagc     5760

tacttgcatt tgattatttc cttttttttt ttttttaact cggaaacaca actggggaaa     5820

tatattcttt cccagtgatt ataaacaatc tttttctttt ttttaagtcc ttttggcttc     5880

tagagctcat aggaaaatgg acttgatttg aaattggagc cagagtttac tcgtgttggt     5940

tatctattca tcagcttcct gacatgttaa gagaatacat taaagagaaa atactgtttt     6000

ttaatcctaa aatttttctt ccactaagat aaaccaaatg tccttacata tatgtaaacc     6060

catctattta aacgcaaagg tgggttgatg tcagtttaca tagcagaaag cattcactat     6120

cctctaagat ttgtttctgc aaaactttca ttgctttaga attttaaaat ttcaccttgt     6180

acaatggcca gcccctaaag caggaaacat ttataatgga ttatatggaa acatcctccc     6240

agtacttgcc cagcccttga atcatgtggc ttttcagtga aaggaaagat tctttttcta     6300

ggaaaaatga gcctatttta ttttatttta ttttattttt tgacacaaac tgtagatttt     6360

agcagccctg gcccaaagga atttgattac ttttgtttta aacagtacaa aggggacact     6420

ataattacaa aaacatcctt aactgatttg agttgttttt atttctttgg atatattttc     6480

agagtggtaa attgtgtgtg agaattacaa atgattattc ttttagtggt ttcttagcct     6540

ctcttacagc ccacggggat agtactgtac atcaatacct tcatatgaaa tttttatatg     6600

caatgaaaat aaaagcatgg gttgattctg cctatttatg actcaatctt ttacaaataa     6660

aagattattc attttaaatt atagttcaat cagcatgtct cttaggatac tgaacgtggt     6720

tgaaatgaaa ggatagtgac atcataagtt agtactgata ttcataacca aataaagcca     6780

acttgagtaa ttttgctaca ttaaaaatta ccaaaattac ttagatggcc tataagatta     6840

agcatggtgt tttctaagca agctttgaaa ggggccttcc atacttactt aattgaatat     6900

tctgggatat tgaaaattat tcagatactt gacaattatt tttggttacc tactccgcaa     6960

actacaaagt tttaaggact caacaataag ttaatgagac acagtgtttg ctttcatgga     7020

gcttacagtc tggaggggac aaaggcttaa acaatactca tataattata tatgtgatca     7080

gtacaatgaa ggagctcagt ggggtaaata agcaggaacc tgaacttgat ctgttccgga     7140

gggccacaga aggcttcctt gaggccttga gaaagtgatt tgcatctgag ttctgaagga     7200

ttgtaagagg taactaggga aaaagttgac aggaagagga aggggatcca gacaagaaac     7260

atttgcaaag atcttgaggc ataaatgagc ttgagacatc tggagaaact gaggaaaagt     7320

gagagagtag gcagggcctg gagccgcaga gccattgcta accatcctgt gtgagatatc     7380

ccccattctg tagctttatt ctcataaccc tgctcaattt tctttataac acttctcaca     7440

gatttatata cgtgtttgtt tttgttatct gtctctccca ccagaccaca gctccatgag     7500

agcaaggtct ttgcttacca atatatcact agcacttaaa actatgcctg gtacacagta     7560

ggttcttaat atgtgttgaa tatagccatc aaattgatat tggatataat tcaatctgat     7620

aagatatttt gagatattaa agagttttta acttgatacc ataaaaa                   7667


<210>  96
<211>  8379
<212>  DNA
<213>  Homo sapiens

<400>  96
cactgccctg cggtgttttg aactgccttc ttacagacgt catacagccc ttgaggaata       60

gtttctgcct ggtgagattg aatgatagtt ctcattcaca aaaccctgga ttctaagcag      120

ggacacacag aaattacttt cgcaggtaaa tcagcccacc cagccaaagt gtggagagat      180

ttgttccttg gctgacttct ttgctccacg gagaggagtg ttttcctgtg cttgccctga      240

aatggaactt ccttgacagc tctcccgtgt tacagtacct cccggtcatt ttctttttct      300

ctctctctac ctgcgctctt cgagtgtcag aaacctttaa agctgttact atggaattgc      360

aaaaaagaga tcaagtgact ctttcactat gctggtttcc cttgtgaccc agatgaagaa      420

tcaattcaga attcagttcc tcccttggca ttgcaagaca cagaagaaac tgtcacttcc      480

taacagccta gtactggagt aaattcagta tgaaggaaga aagcgctcct gcgtgttaga      540

accttgccca tgagctggac cgaggacagg agatggactc caggaaaatt ggatttcttc      600

aagcagcctc ccttggaaat ggaatatctt taaaatcttc tttgcagaaa gacagttaga      660

atgtattaat cagaatagtt gaagacttat tttccttttt attttttttc aaaatgagca      720

ttattatgaa gccaagatcc cgatctacaa gttccctaag gactgcagag gcagtttgtt      780

ttgatgtgga caatggcaca tctgcgggac ggagtccctt ggatcccatg accagcccag      840

gatccgggct aattctccaa gcaaattttg tccacagtca acgacgggag tccttcctgt      900

atcgatccga cagcgattat gacctctctc caaagtctat gtcccggaac tcctccattg      960

ccagtgatat acacggagat gacttgattg tgactccatt tgctcaggtc ttggccagtc     1020

tgcgaactgt acgaaacaac tttgctgcat taactaattt gcaagatcga gcacctagca     1080

aaagatcacc catgtgcaac caaccatcca tcaacaaagc caccataaca gaggaggcct     1140

accagaaact ggccagcgag accctggagg agctggactg gtgtctggac cagctagaga     1200

ccctacagac caggcactcc gtcagtgaga tggcctccaa caagtttaaa aggatgctta     1260

atcgggagct cacccatctc tctgaaatga gtcggtctgg aaatcaagtg tcagagttta     1320

tatcaaacac attcttagat aagcaacatg aagtggaaat tccttctcca actcagaagg     1380

aaaaggagaa aaagaaaaga ccaatgtctc agatcagtgg agtcaagaaa ttgatgcaca     1440

gctctagtct gactaattca agtatcccaa ggtttggagt taaaactgaa caagaagatg     1500

tccttgccaa ggaactagaa gatgtgaaca aatggggtct tcatgttttc agaatagcag     1560

agttgtctgg taaccggccc ttgactgtta tcatgcacac catttttcag gaacgggatt     1620

tattaaaaac atttaaaatt ccagtagata ctttaattac atatcttatg actctcgaag     1680

accattacca tgctgatgtg gcctatcaca acaatatcca tgctgcagat gttgtccagt     1740

ctactcatgt gctattatct acacctgctt tggaggctgt gtttacagat ttggagattc     1800

ttgcagcaat ttttgccagt gcaatacatg atgtagatca tcctggtgtg tccaatcaat     1860

ttctgatcaa tacaaactct gaacttgcct tgatgtacaa tgattcctca gtcttagaga     1920

accatcattt ggctgtgggc tttaaattgc ttcaggaaga aaactgtgac attttccaga     1980

atttgaccaa aaaacaaaga caatctttaa ggaaaatggt cattgacatc gtacttgcaa     2040

cagatatgtc aaaacacatg aatctactgg ctgatttgaa gactatggtt gaaactaaga     2100

aagtgacaag ctctggagtt cttcttcttg ataattattc cgataggatt caggttcttc     2160

agaatatggt gcactgtgca gatctgagca acccaacaaa gcctctccag ctgtaccgcc     2220

agtggacgga ccggataatg gaggagttct tccgccaagg agaccgagag agggaacgtg     2280

gcatggagat aagccccatg tgtgacaagc acaatgcttc cgtggaaaaa tcacaggtgg     2340

gcttcataga ctatattgtt catcccctct gggagacatg ggcagacctc gtccaccctg     2400

acgcccagga tattttggac actttggagg acaatcgtga atggtaccag agcacaatcc     2460

ctcagagccc ctctcctgca cctgatgacc cagaggaggg ccggcagggt caaactgaga     2520

aattccagtt tgaactaact ttagaggaag atggtgagtc agacacggaa aaggacagtg     2580

gcagtcaagt ggaagaagac actagctgca gtgactccaa gactctttgt actcaagact     2640

cagagtctac tgaaattccc cttgatgaac aggttgaaga ggaggcagta ggggaagaag     2700

aggaaagcca gcctgaagcc tgtgtcatag atgatcgttc tcctgacacg taacagtgca     2760

aaaactttca tgcctttttt ttttttaagt agaaaaattg tttccaaagt gcatgtcaca     2820

tgccacaacc acggtcacac ctcactgtca tctgccagga cgtttgttga acaaaactga     2880

ccttgactac tcagtccagc gctcaggaat atcgtaacca gttttttcac ctccatgtca     2940

tccgagcaag gtggacatct tcacgaacag cgtttttaac aagatttcag cttggtagag     3000

ctgacaaagc agataaaatc tactccaaat tattttcaag agagtgtgac tcatcaggca     3060

gcccaaaagt ttattggact tggggtttct attccttttt atttgtttgc aatattttca     3120

gaagaaaggc attgcacaga gtgaacttaa tggacgaagc aacaaatatg tcaagaacag     3180

gacatagcac gaatctgtta ccagtaggag gaggatgagc cacagaaatt gcataatttt     3240

ctaatttcaa gtcttcctga tacatgactg aatagtgtgg ttcagtgagc tgcactgacc     3300

tctacatttt gtatgatatg taaaacagat tttttgtaga gcttactttt attattaaat     3360

gtattgaggt attatattta aaaaaaacta tgttcagaac ttcatctgcc actggttatt     3420

tttttctaag gagtaacttg caagttttca gtacaaatct gtgctacact ggataaaaat     3480

ctaatttatg aattttactt gcaccttata gttcatagca attaactgat ttgtagtgat     3540

tcattgtttg ttttatatac caatgacttc catattttaa aagagaaaaa caactttatg     3600

ttgcaggaaa ccctttttgt aagtctttat tatttacttt gcattttgtt tcactctttc     3660

cagataagca gagttgctct tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt     3720

ctataatact tttatgtgtg ttatatcaaa tgtgtcttaa gcttcatgca aactcagtca     3780

tcagttcgtg ttgtctgaag caagtgggag atatataaat acccagtagc taaaatggtc     3840

agtctttttt agatgttttc ctacttagta tctcctaata acgttttgct gtgtcactag     3900

atgttcattt cacaagtgca tgtctttcta ataatccaca catttcatgc tctaataatc     3960

cacacatttc atgctcattt ttattgtttt tacagccagt tatagtaaga aaaaggtttt     4020

tccccttgtg ctgctttata atttagcgtg tgtctgaacc ttatccatgt ttgctagatg     4080

aggtcttgtc aaatatatca ctaccattgt caccggtgaa aagaaacagg tagttaagtt     4140

agggttaaca ttcatttcaa ccacgaggtt gtatatcatg actagctttt actcttggtt     4200

tacagagaaa agttaaacag ccaactaggc agtttttaag aatattaaca atatattaac     4260

aaacaccaat acaactaatc ctatttggtt ttaatgattt caccatggga ttaagaacta     4320

tatcaggaac atccctgaga aacggtttta agtgtagcaa ctactcttcc ttaatggaca     4380

gccacataac gtgtaggaag tcctttatca cttatcctcg atccataagc atatcttgca     4440

gaggggaact acttctttaa acacatggag ggaaagaaga tgatgccact ggcaccagag     4500

ggttagtact gtgatgcatc ctaaaatatt tattatattg gtaaaaattc tggttaaata     4560

aaaaattaga gatcactctt ggctgatttc agcaccagga actgtattac agttttagag     4620

attaattcct agtgtttacc tgattatagc agttggcatc atggggcatt taattctgac     4680

tttatcccca cgtcagcctt aataaagtct tctttacctt ctctatgaag actttaaagc     4740

ccaaataatc atttttcaca ttgatattca agaattgaga tagatagaag ccaaagtggg     4800

tatctgacaa gtggaaaatc aaacgtttaa gaagaattac aactctgaaa agcatttata     4860

tgtggaactt ctcaaggagc ctcctgggga ctggaaagta agtcatcagc caggcaaatg     4920

actcatgctg aagagagtcc ccatttcagt cccctgagat ctagctgatg cttagatcct     4980

ttgaaataaa aattatgtct ttataactct gatcttttac ataaagcaga agaggaatca     5040

actagttaat tgcaaggttt ctactctgtt tcctctgtaa agatcagatg gtaatctttc     5100

aaataagaaa aaaataaaga cgtatgtttg accaagtagt ttcacaagaa tatttgggaa     5160

cttgtttctt ttaattttat ttgtccctga gtgaagtcta gaaagaaagg taaagagtct     5220

agagtttatt cctctttcca aaacattctc attcctctcc tccctacact tagtatttcc     5280

cccacagagt gcctagaatc ttaataatga ataaaataaa aagcagcaat atgtcattaa     5340

caaatccaga cctgaaaggg taaagggttt ataactgcac taataaagag aggctctttt     5400

tttttcttcc agtttgttgg tttttaatgg taccgtgttg taaagatacc cactaatgga     5460

caatcaaatt gcagaaaagg ctcaatatcc aagagacagg gactaatgca ctgtacaatc     5520

tgcttatcct tgcccttctc tcttgccaaa gtgtgcttca gaaatatata ctgctttaaa     5580

aaagaataaa agaatatcct tttacaagtg gctttacatt tcctaaaatg ccataagaaa     5640

atgcaatatc tgggtactgt atggggaaaa aaatgtccaa gtttgtgtaa aaccagtgca     5700

tttcagcttg caagttactg aacacaataa tgctgtttta attttgtttt atatcagtta     5760

aaattcacaa taatgtagat agaacaaatt acagacaagg aaagaaaaaa cttgaatgaa     5820

atggatttta cagaaagctt tatgataatt tttgaatgca ttatttattt tttgtgccat     5880

gcattttttt tctcaccaaa tgaccttacc tgtaatacag tcttgtttgt ctgtttacaa     5940

ccatgtattt attgcaatgt acatactgta atgttaattg taaattatct gttcttatta     6000

aaacatcatc ccatgatggg atggtgttga tatatttgga aactcttggt gagagaatga     6060

atggtgtgta tacatactct gtacattttt cttttctcct gtaatatagt cttgtcacct     6120

tagagcttgt ttatggaaga ttcaagaaaa ctataaaata cttaaagata tataaattta     6180

aaaaaacata gctgcaggtc tttggtccca gggctgtgcc ttaactttaa ccaatatttt     6240

cttctgtttt gctgcatttg aaaggtaaca gtggagctag ggctgggcat tttacatcca     6300

ggcttttaat tgattagaat tctgccaata ggtggatttt acaaaaccac agacaacctc     6360

tgaaagattc tgagaccctt ttgagacaga agctcttaag tacttcttgc cagggagcag     6420

cactgcatgt gtgatggttg tttgccatct gttgatcagg aactacttca gctacttgca     6480

tttgattatt tccttttttt ttttttttaa ctcggaaaca caactgggga aatatattct     6540

ttcccagtga ttataaacaa tctttttctt ttttttaagt ccttttggct tctagagctc     6600

ataggaaaat ggacttgatt tgaaattgga gccagagttt actcgtgttg gttatctatt     6660

catcagcttc ctgacatgtt aagagaatac attaaagaga aaatactgtt ttttaatcct     6720

aaaatttttc ttccactaag ataaaccaaa tgtccttaca tatatgtaaa cccatctatt     6780

taaacgcaaa ggtgggttga tgtcagttta catagcagaa agcattcact atcctctaag     6840

atttgtttct gcaaaacttt cattgcttta gaattttaaa atttcacctt gtacaatggc     6900

cagcccctaa agcaggaaac atttataatg gattatatgg aaacatcctc ccagtacttg     6960

cccagccctt gaatcatgtg gcttttcagt gaaaggaaag attctttttc taggaaaaat     7020

gagcctattt tattttattt tattttattt tttgacacaa actgtagatt ttagcagccc     7080

tggcccaaag gaatttgatt acttttgttt taaacagtac aaaggggaca ctataattac     7140

aaaaacatcc ttaactgatt tgagttgttt ttatttcttt ggatatattt tcagagtggt     7200

aaattgtgtg tgagaattac aaatgattat tcttttagtg gtttcttagc ctctcttaca     7260

gcccacgggg atagtactgt acatcaatac cttcatatga aatttttata tgcaatgaaa     7320

ataaaagcat gggttgattc tgcctattta tgactcaatc ttttacaaat aaaagattat     7380

tcattttaaa ttatagttca atcagcatgt ctcttaggat actgaacgtg gttgaaatga     7440

aaggatagtg acatcataag ttagtactga tattcataac caaataaagc caacttgagt     7500

aattttgcta cattaaaaat taccaaaatt acttagatgg cctataagat taagcatggt     7560

gttttctaag caagctttga aaggggcctt ccatacttac ttaattgaat attctgggat     7620

attgaaaatt attcagatac ttgacaatta tttttggtta cctactccgc aaactacaaa     7680

gttttaagga ctcaacaata agttaatgag acacagtgtt tgctttcatg gagcttacag     7740

tctggagggg acaaaggctt aaacaatact catataatta tatatgtgat cagtacaatg     7800

aaggagctca gtggggtaaa taagcaggaa cctgaacttg atctgttccg gagggccaca     7860

gaaggcttcc ttgaggcctt gagaaagtga tttgcatctg agttctgaag gattgtaaga     7920

ggtaactagg gaaaaagttg acaggaagag gaaggggatc cagacaagaa acatttgcaa     7980

agatcttgag gcataaatga gcttgagaca tctggagaaa ctgaggaaaa gtgagagagt     8040

aggcagggcc tggagccgca gagccattgc taaccatcct gtgtgagata tcccccattc     8100

tgtagcttta ttctcataac cctgctcaat tttctttata acacttctca cagatttata     8160

tacgtgtttg tttttgttat ctgtctctcc caccagacca cagctccatg agagcaaggt     8220

ctttgcttac caatatatca ctagcactta aaactatgcc tggtacacag taggttctta     8280

atatgtgttg aatatagcca tcaaattgat attggatata attcaatctg ataagatatt     8340

ttgagatatt aaagagtttt taacttgata ccataaaaa                            8379


<210>  97
<211>  7545
<212>  DNA
<213>  Homo sapiens

<400>  97
ctttcttgca actaagcatc ttgacataca ttattcatta agccctggag ctcgggagag       60

aaagatgcag acccttagat ctttagatat tcctttatca cgtggatttt ctttattcag      120

aatagttgct gaattttgtg ccattctgga gtcttacaaa tggcatgtat tcgatgggaa      180

gacggctgga tgggatttaa tgcgaggctt tcttatgtat acttaattac caaaaatctt      240

taaaaactca tactctgcgt ggcttgtgga ggttgttaaa gtgtcgagat tttgaagcta      300

aatacatttt agagcttact atatatatac atatatatat atatacatat aatcaatcaa      360

aaatgcctga agcaaactat ttactgtcag tgtcttgggg ctacataaag tttaaaagga      420

tgcttaatcg ggagctcacc catctctctg aaatgagtcg gtctggaaat caagtgtcag      480

agtttatatc aaacacattc ttagataagc aacatgaagt ggaaattcct tctccaactc      540

agaaggaaaa ggagaaaaag aaaagaccaa tgtctcagat cagtggagtc aagaaattga      600

tgcacagctc tagtctgact aattcaagta tcccaaggtt tggagttaaa actgaacaag      660

aagatgtcct tgccaaggaa ctagaagatg tgaacaaatg gggtcttcat gttttcagaa      720

tagcagagtt gtctggtaac cggcccttga ctgttatcat gcacaccatt tttcaggaac      780

gggatttatt aaaaacattt aaaattccag tagatacttt aattacatat cttatgactc      840

tcgaagacca ttaccatgct gatgtggcct atcacaacaa tatccatgct gcagatgttg      900

tccagtctac tcatgtgcta ttatctacac ctgctttgga ggctgtgttt acagatttgg      960

agattcttgc agcaattttt gccagtgcaa tacatgatgt agatcatcct ggtgtgtcca     1020

atcaatttct gatcaataca aactctgaac ttgccttgat gtacaatgat tcctcagtct     1080

tagagaacca tcatttggct gtgggcttta aattgcttca ggaagaaaac tgtgacattt     1140

tccagaattt gaccaaaaaa caaagacaat ctttaaggaa aatggtcatt gacatcgtac     1200

ttgcaacaga tatgtcaaaa cacatgaatc tactggctga tttgaagact atggttgaaa     1260

ctaagaaagt gacaagctct ggagttcttc ttcttgataa ttattccgat aggattcagg     1320

ttcttcagaa tatggtgcac tgtgcagatc tgagcaaccc aacaaagcct ctccagctgt     1380

accgccagtg gacggaccgg ataatggagg agttcttccg ccaaggagac cgagagaggg     1440

aacgtggcat ggagataagc cccatgtgtg acaagcacaa tgcttccgtg gaaaaatcac     1500

aggtgggctt catagactat attgttcatc ccctctggga gacatgggca gacctcgtcc     1560

accctgacgc ccaggatatt ttggacactt tggaggacaa tcgtgaatgg taccagagca     1620

caatccctca gagcccctct cctgcacctg atgacccaga ggagggccgg cagggtcaaa     1680

ctgagaaatt ccagtttgaa ctaactttag aggaagatgg tgagtcagac acggaaaagg     1740

acagtggcag tcaagtggaa gaagacacta gctgcagtga ctccaagact ctttgtactc     1800

aagactcaga gtctactgaa attccccttg atgaacaggt tgaagaggag gcagtagggg     1860

aagaagagga aagccagcct gaagcctgtg tcatagatga tcgttctcct gacacgtaac     1920

agtgcaaaaa ctttcatgcc tttttttttt ttaagtagaa aaattgtttc caaagtgcat     1980

gtcacatgcc acaaccacgg tcacacctca ctgtcatctg ccaggacgtt tgttgaacaa     2040

aactgacctt gactactcag tccagcgctc aggaatatcg taaccagttt tttcacctcc     2100

atgtcatccg agcaaggtgg acatcttcac gaacagcgtt tttaacaaga tttcagcttg     2160

gtagagctga caaagcagat aaaatctact ccaaattatt ttcaagagag tgtgactcat     2220

caggcagccc aaaagtttat tggacttggg gtttctattc ctttttattt gtttgcaata     2280

ttttcagaag aaaggcattg cacagagtga acttaatgga cgaagcaaca aatatgtcaa     2340

gaacaggaca tagcacgaat ctgttaccag taggaggagg atgagccaca gaaattgcat     2400

aattttctaa tttcaagtct tcctgataca tgactgaata gtgtggttca gtgagctgca     2460

ctgacctcta cattttgtat gatatgtaaa acagattttt tgtagagctt acttttatta     2520

ttaaatgtat tgaggtatta tatttaaaaa aaactatgtt cagaacttca tctgccactg     2580

gttatttttt tctaaggagt aacttgcaag ttttcagtac aaatctgtgc tacactggat     2640

aaaaatctaa tttatgaatt ttacttgcac cttatagttc atagcaatta actgatttgt     2700

agtgattcat tgtttgtttt atataccaat gacttccata ttttaaaaga gaaaaacaac     2760

tttatgttgc aggaaaccct ttttgtaagt ctttattatt tactttgcat tttgtttcac     2820

tctttccaga taagcagagt tgctcttcac cagtgttttt cttcatgtgc aaagtgacta     2880

tttgttctat aatactttta tgtgtgttat atcaaatgtg tcttaagctt catgcaaact     2940

cagtcatcag ttcgtgttgt ctgaagcaag tgggagatat ataaataccc agtagctaaa     3000

atggtcagtc ttttttagat gttttcctac ttagtatctc ctaataacgt tttgctgtgt     3060

cactagatgt tcatttcaca agtgcatgtc tttctaataa tccacacatt tcatgctcta     3120

ataatccaca catttcatgc tcatttttat tgtttttaca gccagttata gtaagaaaaa     3180

ggtttttccc cttgtgctgc tttataattt agcgtgtgtc tgaaccttat ccatgtttgc     3240

tagatgaggt cttgtcaaat atatcactac cattgtcacc ggtgaaaaga aacaggtagt     3300

taagttaggg ttaacattca tttcaaccac gaggttgtat atcatgacta gcttttactc     3360

ttggtttaca gagaaaagtt aaacagccaa ctaggcagtt tttaagaata ttaacaatat     3420

attaacaaac accaatacaa ctaatcctat ttggttttaa tgatttcacc atgggattaa     3480

gaactatatc aggaacatcc ctgagaaacg gttttaagtg tagcaactac tcttccttaa     3540

tggacagcca cataacgtgt aggaagtcct ttatcactta tcctcgatcc ataagcatat     3600

cttgcagagg ggaactactt ctttaaacac atggagggaa agaagatgat gccactggca     3660

ccagagggtt agtactgtga tgcatcctaa aatatttatt atattggtaa aaattctggt     3720

taaataaaaa attagagatc actcttggct gatttcagca ccaggaactg tattacagtt     3780

ttagagatta attcctagtg tttacctgat tatagcagtt ggcatcatgg ggcatttaat     3840

tctgacttta tccccacgtc agccttaata aagtcttctt taccttctct atgaagactt     3900

taaagcccaa ataatcattt ttcacattga tattcaagaa ttgagataga tagaagccaa     3960

agtgggtatc tgacaagtgg aaaatcaaac gtttaagaag aattacaact ctgaaaagca     4020

tttatatgtg gaacttctca aggagcctcc tggggactgg aaagtaagtc atcagccagg     4080

caaatgactc atgctgaaga gagtccccat ttcagtcccc tgagatctag ctgatgctta     4140

gatcctttga aataaaaatt atgtctttat aactctgatc ttttacataa agcagaagag     4200

gaatcaacta gttaattgca aggtttctac tctgtttcct ctgtaaagat cagatggtaa     4260

tctttcaaat aagaaaaaaa taaagacgta tgtttgacca agtagtttca caagaatatt     4320

tgggaacttg tttcttttaa ttttatttgt ccctgagtga agtctagaaa gaaaggtaaa     4380

gagtctagag tttattcctc tttccaaaac attctcattc ctctcctccc tacacttagt     4440

atttccccca cagagtgcct agaatcttaa taatgaataa aataaaaagc agcaatatgt     4500

cattaacaaa tccagacctg aaagggtaaa gggtttataa ctgcactaat aaagagaggc     4560

tctttttttt tcttccagtt tgttggtttt taatggtacc gtgttgtaaa gatacccact     4620

aatggacaat caaattgcag aaaaggctca atatccaaga gacagggact aatgcactgt     4680

acaatctgct tatccttgcc cttctctctt gccaaagtgt gcttcagaaa tatatactgc     4740

tttaaaaaag aataaaagaa tatcctttta caagtggctt tacatttcct aaaatgccat     4800

aagaaaatgc aatatctggg tactgtatgg ggaaaaaaat gtccaagttt gtgtaaaacc     4860

agtgcatttc agcttgcaag ttactgaaca caataatgct gttttaattt tgttttatat     4920

cagttaaaat tcacaataat gtagatagaa caaattacag acaaggaaag aaaaaacttg     4980

aatgaaatgg attttacaga aagctttatg ataatttttg aatgcattat ttattttttg     5040

tgccatgcat tttttttctc accaaatgac cttacctgta atacagtctt gtttgtctgt     5100

ttacaaccat gtatttattg caatgtacat actgtaatgt taattgtaaa ttatctgttc     5160

ttattaaaac atcatcccat gatgggatgg tgttgatata tttggaaact cttggtgaga     5220

gaatgaatgg tgtgtataca tactctgtac atttttcttt tctcctgtaa tatagtcttg     5280

tcaccttaga gcttgtttat ggaagattca agaaaactat aaaatactta aagatatata     5340

aatttaaaaa aacatagctg caggtctttg gtcccagggc tgtgccttaa ctttaaccaa     5400

tattttcttc tgttttgctg catttgaaag gtaacagtgg agctagggct gggcatttta     5460

catccaggct tttaattgat tagaattctg ccaataggtg gattttacaa aaccacagac     5520

aacctctgaa agattctgag acccttttga gacagaagct cttaagtact tcttgccagg     5580

gagcagcact gcatgtgtga tggttgtttg ccatctgttg atcaggaact acttcagcta     5640

cttgcatttg attatttcct tttttttttt ttttaactcg gaaacacaac tggggaaata     5700

tattctttcc cagtgattat aaacaatctt tttctttttt ttaagtcctt ttggcttcta     5760

gagctcatag gaaaatggac ttgatttgaa attggagcca gagtttactc gtgttggtta     5820

tctattcatc agcttcctga catgttaaga gaatacatta aagagaaaat actgtttttt     5880

aatcctaaaa tttttcttcc actaagataa accaaatgtc cttacatata tgtaaaccca     5940

tctatttaaa cgcaaaggtg ggttgatgtc agtttacata gcagaaagca ttcactatcc     6000

tctaagattt gtttctgcaa aactttcatt gctttagaat tttaaaattt caccttgtac     6060

aatggccagc ccctaaagca ggaaacattt ataatggatt atatggaaac atcctcccag     6120

tacttgccca gcccttgaat catgtggctt ttcagtgaaa ggaaagattc tttttctagg     6180

aaaaatgagc ctattttatt ttattttatt ttattttttg acacaaactg tagattttag     6240

cagccctggc ccaaaggaat ttgattactt ttgttttaaa cagtacaaag gggacactat     6300

aattacaaaa acatccttaa ctgatttgag ttgtttttat ttctttggat atattttcag     6360

agtggtaaat tgtgtgtgag aattacaaat gattattctt ttagtggttt cttagcctct     6420

cttacagccc acggggatag tactgtacat caataccttc atatgaaatt tttatatgca     6480

atgaaaataa aagcatgggt tgattctgcc tatttatgac tcaatctttt acaaataaaa     6540

gattattcat tttaaattat agttcaatca gcatgtctct taggatactg aacgtggttg     6600

aaatgaaagg atagtgacat cataagttag tactgatatt cataaccaaa taaagccaac     6660

ttgagtaatt ttgctacatt aaaaattacc aaaattactt agatggccta taagattaag     6720

catggtgttt tctaagcaag ctttgaaagg ggccttccat acttacttaa ttgaatattc     6780

tgggatattg aaaattattc agatacttga caattatttt tggttaccta ctccgcaaac     6840

tacaaagttt taaggactca acaataagtt aatgagacac agtgtttgct ttcatggagc     6900

ttacagtctg gaggggacaa aggcttaaac aatactcata taattatata tgtgatcagt     6960

acaatgaagg agctcagtgg ggtaaataag caggaacctg aacttgatct gttccggagg     7020

gccacagaag gcttccttga ggccttgaga aagtgatttg catctgagtt ctgaaggatt     7080

gtaagaggta actagggaaa aagttgacag gaagaggaag gggatccaga caagaaacat     7140

ttgcaaagat cttgaggcat aaatgagctt gagacatctg gagaaactga ggaaaagtga     7200

gagagtaggc agggcctgga gccgcagagc cattgctaac catcctgtgt gagatatccc     7260

ccattctgta gctttattct cataaccctg ctcaattttc tttataacac ttctcacaga     7320

tttatatacg tgtttgtttt tgttatctgt ctctcccacc agaccacagc tccatgagag     7380

caaggtcttt gcttaccaat atatcactag cacttaaaac tatgcctggt acacagtagg     7440

ttcttaatat gtgttgaata tagccatcaa attgatattg gatataattc aatctgataa     7500

gatattttga gatattaaag agtttttaac ttgataccat aaaaa                     7545


<210>  98
<211>  8130
<212>  DNA
<213>  Homo sapiens

<400>  98
agattatagc ccagcgtacg agaagcacga gtcctatagt tggcgtaccc tgaggcctgc       60

cagttcctgc cttaatgcat atgtagtcgt aattgagttc tgacacggcc ttggatgttt      120

ctgtcctaaa tagctgacat tgcatcttca agactgtcat tccagttggc ttttgagtgg      180

atacgtgcag tgagatcatt gacactggaa acactagttc ccattttaat tacttaaaac      240

accacgatga aaagaaatac ctgtgatttg ctttctcgga gcaaaagtgc ctctgaggaa      300

acactacatt ccagtaatga agaggaagac cctttccgcg gaatggaacc ctatcttgtc      360

cggagacttt catgtcgcaa tattcagctt ccccctctcg ccttcagaca gttggaacaa      420

gctgacttga aaagtgaatc agagaacatt caacgaccaa ccagcctccc cctgaagatt      480

ctgccgctga ttgctatcac ttctgcagaa tccagtggtt ttgatgtgga caatggcaca      540

tctgcgggac ggagtccctt ggatcccatg accagcccag gatccgggct aattctccaa      600

gcaaattttg tccacagtca acgacgggag tccttcctgt atcgatccga cagcgattat      660

gacctctctc caaagtctat gtcccggaac tcctccattg ccagtgatat acacggagat      720

gacttgattg tgactccatt tgctcaggtc ttggccagtc tgcgaactgt acgaaacaac      780

tttgctgcat taactaattt gcaagatcga gcacctagca aaagatcacc catgtgcaac      840

caaccatcca tcaacaaagc caccataaca gaggaggcct accagaaact ggccagcgag      900

accctggagg agctggactg gtgtctggac cagctagaga ccctacagac caggcactcc      960

gtcagtgaga tggcctccaa caagtttaaa aggatgctta atcgggagct cacccatctc     1020

tctgaaatga gtcggtctgg aaatcaagtg tcagagttta tatcaaacac attcttagat     1080

aagcaacatg aagtggaaat tccttctcca actcagaagg aaaaggagaa aaagaaaaga     1140

ccaatgtctc agatcagtgg agtcaagaaa ttgatgcaca gctctagtct gactaattca     1200

agtatcccaa ggtttggagt taaaactgaa caagaagatg tccttgccaa ggaactagaa     1260

gatgtgaaca aatggggtct tcatgttttc agaatagcag agttgtctgg taaccggccc     1320

ttgactgtta tcatgcacac catttttcag gaacgggatt tattaaaaac atttaaaatt     1380

ccagtagata ctttaattac atatcttatg actctcgaag accattacca tgctgatgtg     1440

gcctatcaca acaatatcca tgctgcagat gttgtccagt ctactcatgt gctattatct     1500

acacctgctt tggaggctgt gtttacagat ttggagattc ttgcagcaat ttttgccagt     1560

gcaatacatg atgtagatca tcctggtgtg tccaatcaat ttctgatcaa tacaaactct     1620

gaacttgcct tgatgtacaa tgattcctca gtcttagaga accatcattt ggctgtgggc     1680

tttaaattgc ttcaggaaga aaactgtgac attttccaga atttgaccaa aaaacaaaga     1740

caatctttaa ggaaaatggt cattgacatc gtacttgcaa cagatatgtc aaaacacatg     1800

aatctactgg ctgatttgaa gactatggtt gaaactaaga aagtgacaag ctctggagtt     1860

cttcttcttg ataattattc cgataggatt caggttcttc agaatatggt gcactgtgca     1920

gatctgagca acccaacaaa gcctctccag ctgtaccgcc agtggacgga ccggataatg     1980

gaggagttct tccgccaagg agaccgagag agggaacgtg gcatggagat aagccccatg     2040

tgtgacaagc acaatgcttc cgtggaaaaa tcacaggtgg gcttcataga ctatattgtt     2100

catcccctct gggagacatg ggcagacctc gtccaccctg acgcccagga tattttggac     2160

actttggagg acaatcgtga atggtaccag agcacaatcc ctcagagccc ctctcctgca     2220

cctgatgacc cagaggaggg ccggcagggt caaactgaga aattccagtt tgaactaact     2280

ttagaggaag atggtgagtc agacacggaa aaggacagtg gcagtcaagt ggaagaagac     2340

actagctgca gtgactccaa gactctttgt actcaagact cagagtctac tgaaattccc     2400

cttgatgaac aggttgaaga ggaggcagta ggggaagaag aggaaagcca gcctgaagcc     2460

tgtgtcatag atgatcgttc tcctgacacg taacagtgca aaaactttca tgcctttttt     2520

ttttttaagt agaaaaattg tttccaaagt gcatgtcaca tgccacaacc acggtcacac     2580

ctcactgtca tctgccagga cgtttgttga acaaaactga ccttgactac tcagtccagc     2640

gctcaggaat atcgtaacca gttttttcac ctccatgtca tccgagcaag gtggacatct     2700

tcacgaacag cgtttttaac aagatttcag cttggtagag ctgacaaagc agataaaatc     2760

tactccaaat tattttcaag agagtgtgac tcatcaggca gcccaaaagt ttattggact     2820

tggggtttct attccttttt atttgtttgc aatattttca gaagaaaggc attgcacaga     2880

gtgaacttaa tggacgaagc aacaaatatg tcaagaacag gacatagcac gaatctgtta     2940

ccagtaggag gaggatgagc cacagaaatt gcataatttt ctaatttcaa gtcttcctga     3000

tacatgactg aatagtgtgg ttcagtgagc tgcactgacc tctacatttt gtatgatatg     3060

taaaacagat tttttgtaga gcttactttt attattaaat gtattgaggt attatattta     3120

aaaaaaacta tgttcagaac ttcatctgcc actggttatt tttttctaag gagtaacttg     3180

caagttttca gtacaaatct gtgctacact ggataaaaat ctaatttatg aattttactt     3240

gcaccttata gttcatagca attaactgat ttgtagtgat tcattgtttg ttttatatac     3300

caatgacttc catattttaa aagagaaaaa caactttatg ttgcaggaaa ccctttttgt     3360

aagtctttat tatttacttt gcattttgtt tcactctttc cagataagca gagttgctct     3420

tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt ctataatact tttatgtgtg     3480

ttatatcaaa tgtgtcttaa gcttcatgca aactcagtca tcagttcgtg ttgtctgaag     3540

caagtgggag atatataaat acccagtagc taaaatggtc agtctttttt agatgttttc     3600

ctacttagta tctcctaata acgttttgct gtgtcactag atgttcattt cacaagtgca     3660

tgtctttcta ataatccaca catttcatgc tctaataatc cacacatttc atgctcattt     3720

ttattgtttt tacagccagt tatagtaaga aaaaggtttt tccccttgtg ctgctttata     3780

atttagcgtg tgtctgaacc ttatccatgt ttgctagatg aggtcttgtc aaatatatca     3840

ctaccattgt caccggtgaa aagaaacagg tagttaagtt agggttaaca ttcatttcaa     3900

ccacgaggtt gtatatcatg actagctttt actcttggtt tacagagaaa agttaaacag     3960

ccaactaggc agtttttaag aatattaaca atatattaac aaacaccaat acaactaatc     4020

ctatttggtt ttaatgattt caccatggga ttaagaacta tatcaggaac atccctgaga     4080

aacggtttta agtgtagcaa ctactcttcc ttaatggaca gccacataac gtgtaggaag     4140

tcctttatca cttatcctcg atccataagc atatcttgca gaggggaact acttctttaa     4200

acacatggag ggaaagaaga tgatgccact ggcaccagag ggttagtact gtgatgcatc     4260

ctaaaatatt tattatattg gtaaaaattc tggttaaata aaaaattaga gatcactctt     4320

ggctgatttc agcaccagga actgtattac agttttagag attaattcct agtgtttacc     4380

tgattatagc agttggcatc atggggcatt taattctgac tttatcccca cgtcagcctt     4440

aataaagtct tctttacctt ctctatgaag actttaaagc ccaaataatc atttttcaca     4500

ttgatattca agaattgaga tagatagaag ccaaagtggg tatctgacaa gtggaaaatc     4560

aaacgtttaa gaagaattac aactctgaaa agcatttata tgtggaactt ctcaaggagc     4620

ctcctgggga ctggaaagta agtcatcagc caggcaaatg actcatgctg aagagagtcc     4680

ccatttcagt cccctgagat ctagctgatg cttagatcct ttgaaataaa aattatgtct     4740

ttataactct gatcttttac ataaagcaga agaggaatca actagttaat tgcaaggttt     4800

ctactctgtt tcctctgtaa agatcagatg gtaatctttc aaataagaaa aaaataaaga     4860

cgtatgtttg accaagtagt ttcacaagaa tatttgggaa cttgtttctt ttaattttat     4920

ttgtccctga gtgaagtcta gaaagaaagg taaagagtct agagtttatt cctctttcca     4980

aaacattctc attcctctcc tccctacact tagtatttcc cccacagagt gcctagaatc     5040

ttaataatga ataaaataaa aagcagcaat atgtcattaa caaatccaga cctgaaaggg     5100

taaagggttt ataactgcac taataaagag aggctctttt tttttcttcc agtttgttgg     5160

tttttaatgg taccgtgttg taaagatacc cactaatgga caatcaaatt gcagaaaagg     5220

ctcaatatcc aagagacagg gactaatgca ctgtacaatc tgcttatcct tgcccttctc     5280

tcttgccaaa gtgtgcttca gaaatatata ctgctttaaa aaagaataaa agaatatcct     5340

tttacaagtg gctttacatt tcctaaaatg ccataagaaa atgcaatatc tgggtactgt     5400

atggggaaaa aaatgtccaa gtttgtgtaa aaccagtgca tttcagcttg caagttactg     5460

aacacaataa tgctgtttta attttgtttt atatcagtta aaattcacaa taatgtagat     5520

agaacaaatt acagacaagg aaagaaaaaa cttgaatgaa atggatttta cagaaagctt     5580

tatgataatt tttgaatgca ttatttattt tttgtgccat gcattttttt tctcaccaaa     5640

tgaccttacc tgtaatacag tcttgtttgt ctgtttacaa ccatgtattt attgcaatgt     5700

acatactgta atgttaattg taaattatct gttcttatta aaacatcatc ccatgatggg     5760

atggtgttga tatatttgga aactcttggt gagagaatga atggtgtgta tacatactct     5820

gtacattttt cttttctcct gtaatatagt cttgtcacct tagagcttgt ttatggaaga     5880

ttcaagaaaa ctataaaata cttaaagata tataaattta aaaaaacata gctgcaggtc     5940

tttggtccca gggctgtgcc ttaactttaa ccaatatttt cttctgtttt gctgcatttg     6000

aaaggtaaca gtggagctag ggctgggcat tttacatcca ggcttttaat tgattagaat     6060

tctgccaata ggtggatttt acaaaaccac agacaacctc tgaaagattc tgagaccctt     6120

ttgagacaga agctcttaag tacttcttgc cagggagcag cactgcatgt gtgatggttg     6180

tttgccatct gttgatcagg aactacttca gctacttgca tttgattatt tccttttttt     6240

ttttttttaa ctcggaaaca caactgggga aatatattct ttcccagtga ttataaacaa     6300

tctttttctt ttttttaagt ccttttggct tctagagctc ataggaaaat ggacttgatt     6360

tgaaattgga gccagagttt actcgtgttg gttatctatt catcagcttc ctgacatgtt     6420

aagagaatac attaaagaga aaatactgtt ttttaatcct aaaatttttc ttccactaag     6480

ataaaccaaa tgtccttaca tatatgtaaa cccatctatt taaacgcaaa ggtgggttga     6540

tgtcagttta catagcagaa agcattcact atcctctaag atttgtttct gcaaaacttt     6600

cattgcttta gaattttaaa atttcacctt gtacaatggc cagcccctaa agcaggaaac     6660

atttataatg gattatatgg aaacatcctc ccagtacttg cccagccctt gaatcatgtg     6720

gcttttcagt gaaaggaaag attctttttc taggaaaaat gagcctattt tattttattt     6780

tattttattt tttgacacaa actgtagatt ttagcagccc tggcccaaag gaatttgatt     6840

acttttgttt taaacagtac aaaggggaca ctataattac aaaaacatcc ttaactgatt     6900

tgagttgttt ttatttcttt ggatatattt tcagagtggt aaattgtgtg tgagaattac     6960

aaatgattat tcttttagtg gtttcttagc ctctcttaca gcccacgggg atagtactgt     7020

acatcaatac cttcatatga aatttttata tgcaatgaaa ataaaagcat gggttgattc     7080

tgcctattta tgactcaatc ttttacaaat aaaagattat tcattttaaa ttatagttca     7140

atcagcatgt ctcttaggat actgaacgtg gttgaaatga aaggatagtg acatcataag     7200

ttagtactga tattcataac caaataaagc caacttgagt aattttgcta cattaaaaat     7260

taccaaaatt acttagatgg cctataagat taagcatggt gttttctaag caagctttga     7320

aaggggcctt ccatacttac ttaattgaat attctgggat attgaaaatt attcagatac     7380

ttgacaatta tttttggtta cctactccgc aaactacaaa gttttaagga ctcaacaata     7440

agttaatgag acacagtgtt tgctttcatg gagcttacag tctggagggg acaaaggctt     7500

aaacaatact catataatta tatatgtgat cagtacaatg aaggagctca gtggggtaaa     7560

taagcaggaa cctgaacttg atctgttccg gagggccaca gaaggcttcc ttgaggcctt     7620

gagaaagtga tttgcatctg agttctgaag gattgtaaga ggtaactagg gaaaaagttg     7680

acaggaagag gaaggggatc cagacaagaa acatttgcaa agatcttgag gcataaatga     7740

gcttgagaca tctggagaaa ctgaggaaaa gtgagagagt aggcagggcc tggagccgca     7800

gagccattgc taaccatcct gtgtgagata tcccccattc tgtagcttta ttctcataac     7860

cctgctcaat tttctttata acacttctca cagatttata tacgtgtttg tttttgttat     7920

ctgtctctcc caccagacca cagctccatg agagcaaggt ctttgcttac caatatatca     7980

ctagcactta aaactatgcc tggtacacag taggttctta atatgtgttg aatatagcca     8040

tcaaattgat attggatata attcaatctg ataagatatt ttgagatatt aaagagtttt     8100

taacttgata ccataaaaaa aaaaaaaaaa                                      8130


<210>  99
<211>  7814
<212>  DNA
<213>  Homo sapiens

<400>  99
acaaaggaaa tgccctcact cagctacaag tgcctcctgc tccgtgcggg gcctcagggc       60

cccagagccc cgcaccagct ctgacttctc gtggttcctg gggatcttgg catcgtcctt      120

aaaaatggct tttgtttggg atcctctggg agccacggtg ccaggaccat ctacaagagc      180

caaatcaaga ttgcgtttct caaagtccta cagttttgat gtggacaatg gcacatctgc      240

gggacggagt cccttggatc ccatgaccag cccaggatcc gggctaattc tccaagcaaa      300

ttttgtccac agtcaacgac gggagtcctt cctgtatcga tccgacagcg attatgacct      360

ctctccaaag tctatgtccc ggaactcctc cattgccagt gatatacacg gagatgactt      420

gattgtgact ccatttgctc aggtcttggc cagtctgcga actgtacgaa acaactttgc      480

tgcattaact aatttgcaag atcgagcacc tagcaaaaga tcacccatgt gcaaccaacc      540

atccatcaac aaagccacca taacagagga ggcctaccag aaactggcca gcgagaccct      600

ggaggagctg gactggtgtc tggaccagct agagacccta cagaccaggc actccgtcag      660

tgagatggcc tccaacaagt ttaaaaggat gcttaatcgg gagctcaccc atctctctga      720

aatgagtcgg tctggaaatc aagtgtcaga gtttatatca aacacattct tagataagca      780

acatgaagtg gaaattcctt ctccaactca gaaggaaaag gagaaaaaga aaagaccaat      840

gtctcagatc agtggagtca agaaattgat gcacagctct agtctgacta attcaagtat      900

cccaaggttt ggagttaaaa ctgaacaaga agatgtcctt gccaaggaac tagaagatgt      960

gaacaaatgg ggtcttcatg ttttcagaat agcagagttg tctggtaacc ggcccttgac     1020

tgttatcatg cacaccattt ttcaggaacg ggatttatta aaaacattta aaattccagt     1080

agatacttta attacatatc ttatgactct cgaagaccat taccatgctg atgtggccta     1140

tcacaacaat atccatgctg cagatgttgt ccagtctact catgtgctat tatctacacc     1200

tgctttggag gctgtgttta cagatttgga gattcttgca gcaatttttg ccagtgcaat     1260

acatgatgta gatcatcctg gtgtgtccaa tcaatttctg atcaatacaa actctgaact     1320

tgccttgatg tacaatgatt cctcagtctt agagaaccat catttggctg tgggctttaa     1380

attgcttcag gaagaaaact gtgacatttt ccagaatttg accaaaaaac aaagacaatc     1440

tttaaggaaa atggtcattg acatcgtact tgcaacagat atgtcaaaac acatgaatct     1500

actggctgat ttgaagacta tggttgaaac taagaaagtg acaagctctg gagttcttct     1560

tcttgataat tattccgata ggattcaggt tcttcagaat atggtgcact gtgcagatct     1620

gagcaaccca acaaagcctc tccagctgta ccgccagtgg acggaccgga taatggagga     1680

gttcttccgc caaggagacc gagagaggga acgtggcatg gagataagcc ccatgtgtga     1740

caagcacaat gcttccgtgg aaaaatcaca ggtgggcttc atagactata ttgttcatcc     1800

cctctgggag acatgggcag acctcgtcca ccctgacgcc caggatattt tggacacttt     1860

ggaggacaat cgtgaatggt accagagcac aatccctcag agcccctctc ctgcacctga     1920

tgacccagag gagggccggc agggtcaaac tgagaaattc cagtttgaac taactttaga     1980

ggaagatggt gagtcagaca cggaaaagga cagtggcagt caagtggaag aagacactag     2040

ctgcagtgac tccaagactc tttgtactca agactcagag tctactgaaa ttccccttga     2100

tgaacaggtt gaagaggagg cagtagggga agaagaggaa agccagcctg aagcctgtgt     2160

catagatgat cgttctcctg acacgtaaca gtgcaaaaac tttcatgcct tttttttttt     2220

taagtagaaa aattgtttcc aaagtgcatg tcacatgcca caaccacggt cacacctcac     2280

tgtcatctgc caggacgttt gttgaacaaa actgaccttg actactcagt ccagcgctca     2340

ggaatatcgt aaccagtttt ttcacctcca tgtcatccga gcaaggtgga catcttcacg     2400

aacagcgttt ttaacaagat ttcagcttgg tagagctgac aaagcagata aaatctactc     2460

caaattattt tcaagagagt gtgactcatc aggcagccca aaagtttatt ggacttgggg     2520

tttctattcc tttttatttg tttgcaatat tttcagaaga aaggcattgc acagagtgaa     2580

cttaatggac gaagcaacaa atatgtcaag aacaggacat agcacgaatc tgttaccagt     2640

aggaggagga tgagccacag aaattgcata attttctaat ttcaagtctt cctgatacat     2700

gactgaatag tgtggttcag tgagctgcac tgacctctac attttgtatg atatgtaaaa     2760

cagatttttt gtagagctta cttttattat taaatgtatt gaggtattat atttaaaaaa     2820

aactatgttc agaacttcat ctgccactgg ttattttttt ctaaggagta acttgcaagt     2880

tttcagtaca aatctgtgct acactggata aaaatctaat ttatgaattt tacttgcacc     2940

ttatagttca tagcaattaa ctgatttgta gtgattcatt gtttgtttta tataccaatg     3000

acttccatat tttaaaagag aaaaacaact ttatgttgca ggaaaccctt tttgtaagtc     3060

tttattattt actttgcatt ttgtttcact ctttccagat aagcagagtt gctcttcacc     3120

agtgtttttc ttcatgtgca aagtgactat ttgttctata atacttttat gtgtgttata     3180

tcaaatgtgt cttaagcttc atgcaaactc agtcatcagt tcgtgttgtc tgaagcaagt     3240

gggagatata taaataccca gtagctaaaa tggtcagtct tttttagatg ttttcctact     3300

tagtatctcc taataacgtt ttgctgtgtc actagatgtt catttcacaa gtgcatgtct     3360

ttctaataat ccacacattt catgctctaa taatccacac atttcatgct catttttatt     3420

gtttttacag ccagttatag taagaaaaag gtttttcccc ttgtgctgct ttataattta     3480

gcgtgtgtct gaaccttatc catgtttgct agatgaggtc ttgtcaaata tatcactacc     3540

attgtcaccg gtgaaaagaa acaggtagtt aagttagggt taacattcat ttcaaccacg     3600

aggttgtata tcatgactag cttttactct tggtttacag agaaaagtta aacagccaac     3660

taggcagttt ttaagaatat taacaatata ttaacaaaca ccaatacaac taatcctatt     3720

tggttttaat gatttcacca tgggattaag aactatatca ggaacatccc tgagaaacgg     3780

ttttaagtgt agcaactact cttccttaat ggacagccac ataacgtgta ggaagtcctt     3840

tatcacttat cctcgatcca taagcatatc ttgcagaggg gaactacttc tttaaacaca     3900

tggagggaaa gaagatgatg ccactggcac cagagggtta gtactgtgat gcatcctaaa     3960

atatttatta tattggtaaa aattctggtt aaataaaaaa ttagagatca ctcttggctg     4020

atttcagcac caggaactgt attacagttt tagagattaa ttcctagtgt ttacctgatt     4080

atagcagttg gcatcatggg gcatttaatt ctgactttat ccccacgtca gccttaataa     4140

agtcttcttt accttctcta tgaagacttt aaagcccaaa taatcatttt tcacattgat     4200

attcaagaat tgagatagat agaagccaaa gtgggtatct gacaagtgga aaatcaaacg     4260

tttaagaaga attacaactc tgaaaagcat ttatatgtgg aacttctcaa ggagcctcct     4320

ggggactgga aagtaagtca tcagccaggc aaatgactca tgctgaagag agtccccatt     4380

tcagtcccct gagatctagc tgatgcttag atcctttgaa ataaaaatta tgtctttata     4440

actctgatct tttacataaa gcagaagagg aatcaactag ttaattgcaa ggtttctact     4500

ctgtttcctc tgtaaagatc agatggtaat ctttcaaata agaaaaaaat aaagacgtat     4560

gtttgaccaa gtagtttcac aagaatattt gggaacttgt ttcttttaat tttatttgtc     4620

cctgagtgaa gtctagaaag aaaggtaaag agtctagagt ttattcctct ttccaaaaca     4680

ttctcattcc tctcctccct acacttagta tttcccccac agagtgccta gaatcttaat     4740

aatgaataaa ataaaaagca gcaatatgtc attaacaaat ccagacctga aagggtaaag     4800

ggtttataac tgcactaata aagagaggct cttttttttt cttccagttt gttggttttt     4860

aatggtaccg tgttgtaaag atacccacta atggacaatc aaattgcaga aaaggctcaa     4920

tatccaagag acagggacta atgcactgta caatctgctt atccttgccc ttctctcttg     4980

ccaaagtgtg cttcagaaat atatactgct ttaaaaaaga ataaaagaat atccttttac     5040

aagtggcttt acatttccta aaatgccata agaaaatgca atatctgggt actgtatggg     5100

gaaaaaaatg tccaagtttg tgtaaaacca gtgcatttca gcttgcaagt tactgaacac     5160

aataatgctg ttttaatttt gttttatatc agttaaaatt cacaataatg tagatagaac     5220

aaattacaga caaggaaaga aaaaacttga atgaaatgga ttttacagaa agctttatga     5280

taatttttga atgcattatt tattttttgt gccatgcatt ttttttctca ccaaatgacc     5340

ttacctgtaa tacagtcttg tttgtctgtt tacaaccatg tatttattgc aatgtacata     5400

ctgtaatgtt aattgtaaat tatctgttct tattaaaaca tcatcccatg atgggatggt     5460

gttgatatat ttggaaactc ttggtgagag aatgaatggt gtgtatacat actctgtaca     5520

tttttctttt ctcctgtaat atagtcttgt caccttagag cttgtttatg gaagattcaa     5580

gaaaactata aaatacttaa agatatataa atttaaaaaa acatagctgc aggtctttgg     5640

tcccagggct gtgccttaac tttaaccaat attttcttct gttttgctgc atttgaaagg     5700

taacagtgga gctagggctg ggcattttac atccaggctt ttaattgatt agaattctgc     5760

caataggtgg attttacaaa accacagaca acctctgaaa gattctgaga cccttttgag     5820

acagaagctc ttaagtactt cttgccaggg agcagcactg catgtgtgat ggttgtttgc     5880

catctgttga tcaggaacta cttcagctac ttgcatttga ttatttcctt tttttttttt     5940

tttaactcgg aaacacaact ggggaaatat attctttccc agtgattata aacaatcttt     6000

ttcttttttt taagtccttt tggcttctag agctcatagg aaaatggact tgatttgaaa     6060

ttggagccag agtttactcg tgttggttat ctattcatca gcttcctgac atgttaagag     6120

aatacattaa agagaaaata ctgtttttta atcctaaaat ttttcttcca ctaagataaa     6180

ccaaatgtcc ttacatatat gtaaacccat ctatttaaac gcaaaggtgg gttgatgtca     6240

gtttacatag cagaaagcat tcactatcct ctaagatttg tttctgcaaa actttcattg     6300

ctttagaatt ttaaaatttc accttgtaca atggccagcc cctaaagcag gaaacattta     6360

taatggatta tatggaaaca tcctcccagt acttgcccag cccttgaatc atgtggcttt     6420

tcagtgaaag gaaagattct ttttctagga aaaatgagcc tattttattt tattttattt     6480

tattttttga cacaaactgt agattttagc agccctggcc caaaggaatt tgattacttt     6540

tgttttaaac agtacaaagg ggacactata attacaaaaa catccttaac tgatttgagt     6600

tgtttttatt tctttggata tattttcaga gtggtaaatt gtgtgtgaga attacaaatg     6660

attattcttt tagtggtttc ttagcctctc ttacagccca cggggatagt actgtacatc     6720

aataccttca tatgaaattt ttatatgcaa tgaaaataaa agcatgggtt gattctgcct     6780

atttatgact caatctttta caaataaaag attattcatt ttaaattata gttcaatcag     6840

catgtctctt aggatactga acgtggttga aatgaaagga tagtgacatc ataagttagt     6900

actgatattc ataaccaaat aaagccaact tgagtaattt tgctacatta aaaattacca     6960

aaattactta gatggcctat aagattaagc atggtgtttt ctaagcaagc tttgaaaggg     7020

gccttccata cttacttaat tgaatattct gggatattga aaattattca gatacttgac     7080

aattattttt ggttacctac tccgcaaact acaaagtttt aaggactcaa caataagtta     7140

atgagacaca gtgtttgctt tcatggagct tacagtctgg aggggacaaa ggcttaaaca     7200

atactcatat aattatatat gtgatcagta caatgaagga gctcagtggg gtaaataagc     7260

aggaacctga acttgatctg ttccggaggg ccacagaagg cttccttgag gccttgagaa     7320

agtgatttgc atctgagttc tgaaggattg taagaggtaa ctagggaaaa agttgacagg     7380

aagaggaagg ggatccagac aagaaacatt tgcaaagatc ttgaggcata aatgagcttg     7440

agacatctgg agaaactgag gaaaagtgag agagtaggca gggcctggag ccgcagagcc     7500

attgctaacc atcctgtgtg agatatcccc cattctgtag ctttattctc ataaccctgc     7560

tcaattttct ttataacact tctcacagat ttatatacgt gtttgttttt gttatctgtc     7620

tctcccacca gaccacagct ccatgagagc aaggtctttg cttaccaata tatcactagc     7680

acttaaaact atgcctggta cacagtaggt tcttaatatg tgttgaatat agccatcaaa     7740

ttgatattgg atataattca atctgataag atattttgag atattaaaga gtttttaact     7800

tgataccata aaaa                                                       7814


<210>  100
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Glu Ala Glu Gly Ser Ser Ala Pro Ala Arg Ala Gly Ser Gly Glu 
1               5                   10                  15      


Gly Ser Asp Ser Ala Gly Gly Ala Thr Leu Lys Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg His Glu Gln His His Gln Tyr Pro Leu Arg Gln Pro Gln Phe 
        35                  40                  45              


Arg Leu Leu His Pro His His His Leu Pro Pro Pro Pro Pro Pro Ser 
    50                  55                  60                  


Pro Gln Pro Gln Pro Gln Cys Pro Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Pro Pro Pro Pro Gly Ala Ala Arg Gly Arg Tyr Ala 
                85                  90                  95      


Ser Ser Gly Ala Thr Gly Arg Val Arg His Arg Gly Tyr Ser Asp Thr 
            100                 105                 110         


Glu Arg Tyr Leu Tyr Cys Arg Ala Met Asp Arg Thr Ser Tyr Ala Val 
        115                 120                 125             


Glu Thr Gly His Arg Pro Gly Leu Lys Lys Ser Arg Met Ser Trp Pro 
    130                 135                 140                 


Ser Ser Phe Gln Gly Leu Arg Arg Phe Asp Val Asp Asn Gly Thr Ser 
145                 150                 155                 160 


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
                165                 170                 175     


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
            180                 185                 190         


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
        195                 200                 205             


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
    210                 215                 220                 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
225                 230                 235                 240 


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
                245                 250                 255     


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
            260                 265                 270         


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
        275                 280                 285             


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
    290                 295                 300                 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
305                 310                 315                 320 


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
                325                 330                 335     


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
            340                 345                 350         


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
        355                 360                 365             


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
    370                 375                 380                 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
385                 390                 395                 400 


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
                405                 410                 415     


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
            420                 425                 430         


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
        435                 440                 445             


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
    450                 455                 460                 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
465                 470                 475                 480 


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
                485                 490                 495     


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
            500                 505                 510         


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
        515                 520                 525             


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
    530                 535                 540                 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
545                 550                 555                 560 


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
                565                 570                 575     


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
            580                 585                 590         


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
        595                 600                 605             


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
    610                 615                 620                 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
625                 630                 635                 640 


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
                645                 650                 655     


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
            660                 665                 670         


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
        675                 680                 685             


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
    690                 695                 700                 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
705                 710                 715                 720 


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
                725                 730                 735     


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
            740                 745                 750         


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
        755                 760                 765             


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
    770                 775                 780                 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
785                 790                 795                 800 


Val Ile Asp Asp Arg Ser Pro Asp Thr 
                805                 


<210>  101
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ser Leu Pro Ser Ser Cys Glu Tyr Leu Thr Leu Gly Lys Val Ala 
1               5                   10                  15      


Arg Phe Arg Ser Ala Tyr Val His Gly Ser Pro Tyr Ala Ile Asn Met 
            20                  25                  30          


Pro Ile Asp Ile Lys Pro Gln Arg Arg Arg Phe Asp Val Asp Asn Gly 
        35                  40                  45              


Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser 
    50                  55                  60                  


Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser 
65                  70                  75                  80  


Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met 
                85                  90                  95      


Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile 
            100                 105                 110         


Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn 
        115                 120                 125             


Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg 
    130                 135                 140                 


Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu 
145                 150                 155                 160 


Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp 
                165                 170                 175     


Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu 
            180                 185                 190         


Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His 
        195                 200                 205             


Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser 
    210                 215                 220                 


Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr 
225                 230                 235                 240 


Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly 
                245                 250                 255     


Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro 
            260                 265                 270         


Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu 
        275                 280                 285             


Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu 
    290                 295                 300                 


Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu 
305                 310                 315                 320 


Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr 
                325                 330                 335     


Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His 
            340                 345                 350         


Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu 
        355                 360                 365             


Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala 
    370                 375                 380                 


Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser 
385                 390                 395                 400 


Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn 
                405                 410                 415     


Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu 
            420                 425                 430         


Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln 
        435                 440                 445             


Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp 
    450                 455                 460                 


Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu 
465                 470                 475                 480 


Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser 
                485                 490                 495     


Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser 
            500                 505                 510         


Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile 
        515                 520                 525             


Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met 
    530                 535                 540                 


Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser 
545                 550                 555                 560 


Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp 
                565                 570                 575     


Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu 
            580                 585                 590         


Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro 
        595                 600                 605             


Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe 
    610                 615                 620                 


Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys 
625                 630                 635                 640 


Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys 
                645                 650                 655     


Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu 
            660                 665                 670         


Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu 
        675                 680                 685             


Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
    690                 695                 


<210>  102
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
        195                 200                 205             


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
    210                 215                 220                 


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
225                 230                 235                 240 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
                245                 250                 255     


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
            260                 265                 270         


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
        275                 280                 285             


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
    290                 295                 300                 


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
305                 310                 315                 320 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
                325                 330                 335     


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
            340                 345                 350         


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
        355                 360                 365             


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
    370                 375                 380                 


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
385                 390                 395                 400 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
                405                 410                 415     


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
            420                 425                 430         


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
        435                 440                 445             


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
    450                 455                 460                 


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
465                 470                 475                 480 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
                485                 490                 495     


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
            500                 505                 510         


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
        515                 520                 525             


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
    530                 535                 540                 


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
545                 550                 555                 560 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
                565                 570                 575     


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
            580                 585                 590         


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
        595                 600                 605             


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
    610                 615                 620                 


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
625                 630                 635                 640 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
                645                 650                 655     


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
            660                 665                 670         


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
        675                 680                 685             


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
    690                 695                 700                 


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
705                 710                 715                 720 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
                725                 730                 735     


Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745 


<210>  103
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Met His Val Asn Asn Phe Pro Phe Arg Arg His Ser Trp Ile Cys 
1               5                   10                  15      


Phe Asp Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro 
            20                  25                  30          


Met Thr Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His 
        35                  40                  45              


Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp 
    50                  55                  60                  


Leu Ser Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile 
65                  70                  75                  80  


His Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser 
                85                  90                  95      


Leu Arg Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp 
            100                 105                 110         


Arg Ala Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn 
        115                 120                 125             


Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr 
    130                 135                 140                 


Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr 
145                 150                 155                 160 


Arg His Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu 
                165                 170                 175     


Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln 
            180                 185                 190         


Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val 
        195                 200                 205             


Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro 
    210                 215                 220                 


Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp 
                245                 250                 255     


Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val 
            260                 265                 270         


Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met 
        275                 280                 285             


His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro 
    290                 295                 300                 


Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His 
305                 310                 315                 320 


Ala Asp Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln 
                325                 330                 335     


Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr 
            340                 345                 350         


Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val 
        355                 360                 365             


Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu 
    370                 375                 380                 


Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu 
385                 390                 395                 400 


Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln 
                405                 410                 415     


Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp 
            420                 425                 430         


Ile Val Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp 
        435                 440                 445             


Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu 
    450                 455                 460                 


Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val 
465                 470                 475                 480 


His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg 
                485                 490                 495     


Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg 
            500                 505                 510         


Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn 
        515                 520                 525             


Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His 
    530                 535                 540                 


Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp 
545                 550                 555                 560 


Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile 
                565                 570                 575     


Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln 
            580                 585                 590         


Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly 
        595                 600                 605             


Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr 
    610                 615                 620                 


Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr 
625                 630                 635                 640 


Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu 
                645                 650                 655     


Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp 
            660                 665                 670         


Thr 
    


<210>  104
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His 
1               5                   10                  15      


Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser 
            20                  25                  30          


Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr 
        35                  40                  45              


Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly 
    50                  55                  60                  


Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro 
65                  70                  75                  80  


Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu 
                85                  90                  95      


Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu 
            100                 105                 110         


Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu 
        115                 120                 125             


Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr 
    130                 135                 140                 


Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His 
145                 150                 155                 160 


Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu 
                165                 170                 175     


Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala 
            180                 185                 190         


Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser 
        195                 200                 205             


Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn 
    210                 215                 220                 


Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln 
                245                 250                 255     


Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp 
            260                 265                 270         


Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu 
        275                 280                 285             


Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser 
    290                 295                 300                 


Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser 
305                 310                 315                 320 


Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile 
                325                 330                 335     


Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met 
            340                 345                 350         


Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser 
        355                 360                 365             


Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp 
    370                 375                 380                 


Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu 
385                 390                 395                 400 


Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro 
                405                 410                 415     


Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe 
            420                 425                 430         


Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys 
        435                 440                 445             


Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys 
    450                 455                 460                 


Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu 
465                 470                 475                 480 


Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu 
                485                 490                 495     


Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            500                 505         


<210>  105
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ser Ile Ile Met Lys Pro Arg Ser Arg Ser Thr Ser Ser Leu Arg 
1               5                   10                  15      


Thr Ala Glu Ala Val Cys Phe Asp Val Asp Asn Gly Thr Ser Ala Gly 
            20                  25                  30          


Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu Ile Leu 
        35                  40                  45              


Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg 
    50                  55                  60                  


Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg Asn Ser 
65                  70                  75                  80  


Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr Pro Phe 
                85                  90                  95      


Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe Ala Ala 
            100                 105                 110         


Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro Met Cys 
        115                 120                 125             


Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln 
    130                 135                 140                 


Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln 
145                 150                 155                 160 


Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala Ser Asn 
                165                 170                 175     


Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met 
            180                 185                 190         


Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu 
        195                 200                 205             


Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys 
    210                 215                 220                 


Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu 
225                 230                 235                 240 


Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val 
                245                 250                 255     


Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn 
            260                 265                 270         


Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg 
        275                 280                 285             


Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu 
    290                 295                 300                 


Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr 
305                 310                 315                 320 


Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His 
                325                 330                 335     


Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala 
            340                 345                 350         


Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala 
        355                 360                 365             


Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu 
    370                 375                 380                 


Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val 
385                 390                 395                 400 


Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu 
                405                 410                 415     


Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu 
            420                 425                 430         


Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His 
        435                 440                 445             


Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val 
    450                 455                 460                 


Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln 
465                 470                 475                 480 


Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys 
                485                 490                 495     


Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe 
            500                 505                 510         


Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro 
        515                 520                 525             


Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe 
    530                 535                 540                 


Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val 
545                 550                 555                 560 


His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu 
                565                 570                 575     


Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp 
            580                 585                 590         


Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu 
        595                 600                 605             


Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser 
    610                 615                 620                 


Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr 
625                 630                 635                 640 


Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu 
                645                 650                 655     


Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile 
            660                 665                 670         


Asp Asp Arg Ser Pro Asp Thr 
        675                 


<210>  106
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Pro Glu Ala Asn Tyr Leu Leu Ser Val Ser Trp Gly Tyr Ile Lys 
1               5                   10                  15      


Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser 
            20                  25                  30          


Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp 
        35                  40                  45              


Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu 
    50                  55                  60                  


Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met 
65                  70                  75                  80  


His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys 
                85                  90                  95      


Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys 
            100                 105                 110         


Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro 
        115                 120                 125             


Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys 
    130                 135                 140                 


Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu 
145                 150                 155                 160 


Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His Ala 
                165                 170                 175     


Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu 
            180                 185                 190         


Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser 
        195                 200                 205             


Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile 
    210                 215                 220                 


Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu 
225                 230                 235                 240 


Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn 
                245                 250                 255     


Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg 
            260                 265                 270         


Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His Met 
        275                 280                 285             


Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr 
    290                 295                 300                 


Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val 
305                 310                 315                 320 


Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro 
                325                 330                 335     


Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe 
            340                 345                 350         


Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met 
        355                 360                 365             


Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile 
    370                 375                 380                 


Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His 
385                 390                 395                 400 


Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp 
                405                 410                 415     


Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro 
            420                 425                 430         


Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr 
        435                 440                 445             


Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln 
    450                 455                 460                 


Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln 
465                 470                 475                 480 


Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu 
                485                 490                 495     


Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp 
            500                 505                 510         


Asp Arg Ser Pro Asp Thr 
        515             


<210>  107
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Lys Arg Asn Thr Cys Asp Leu Leu Ser Arg Ser Lys Ser Ala Ser 
1               5                   10                  15      


Glu Glu Thr Leu His Ser Ser Asn Glu Glu Glu Asp Pro Phe Arg Gly 
            20                  25                  30          


Met Glu Pro Tyr Leu Val Arg Arg Leu Ser Cys Arg Asn Ile Gln Leu 
        35                  40                  45              


Pro Pro Leu Ala Phe Arg Gln Leu Glu Gln Ala Asp Leu Lys Ser Glu 
    50                  55                  60                  


Ser Glu Asn Ile Gln Arg Pro Thr Ser Leu Pro Leu Lys Ile Leu Pro 
65                  70                  75                  80  


Leu Ile Ala Ile Thr Ser Ala Glu Ser Ser Gly Phe Asp Val Asp Asn 
                85                  90                  95      


Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly 
            100                 105                 110         


Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu 
        115                 120                 125             


Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser 
    130                 135                 140                 


Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu 
145                 150                 155                 160 


Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg 
                165                 170                 175     


Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys 
            180                 185                 190         


Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr 
        195                 200                 205             


Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp 
    210                 215                 220                 


Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser 
225                 230                 235                 240 


Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr 
                245                 250                 255     


His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile 
            260                 265                 270         


Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro 
        275                 280                 285             


Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser 
    290                 295                 300                 


Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile 
305                 310                 315                 320 


Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu 
                325                 330                 335     


Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu 
            340                 345                 350         


Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln 
        355                 360                 365             


Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile 
    370                 375                 380                 


Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr 
385                 390                 395                 400 


His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu 
                405                 410                 415     


Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu 
            420                 425                 430         


Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val 
        435                 440                 445             


Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr 
    450                 455                 460                 


Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys 
465                 470                 475                 480 


Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys 
                485                 490                 495     


Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr 
            500                 505                 510         


Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val 
        515                 520                 525             


Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr 
    530                 535                 540                 


Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu 
545                 550                 555                 560 


Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg 
                565                 570                 575     


Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly 
            580                 585                 590         


Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys 
        595                 600                 605             


Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr 
    610                 615                 620                 


Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu 
625                 630                 635                 640 


Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser 
                645                 650                 655     


Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys 
            660                 665                 670         


Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu 
        675                 680                 685             


Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser 
    690                 695                 700                 


Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro 
                725                 730                 735     


Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745             


<210>  108
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Phe Val Trp Asp Pro Leu Gly Ala Thr Val Pro Gly Pro Ser 
1               5                   10                  15      


Thr Arg Ala Lys Ser Arg Leu Arg Phe Ser Lys Ser Tyr Ser Phe Asp 
            20                  25                  30          


Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr 
        35                  40                  45              


Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln 
    50                  55                  60                  


Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser 
65                  70                  75                  80  


Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly 
                85                  90                  95      


Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg 
            100                 105                 110         


Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala 
        115                 120                 125             


Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala 
    130                 135                 140                 


Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu 
145                 150                 155                 160 


Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His 
                165                 170                 175     


Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg 
            180                 185                 190         


Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser 
        195                 200                 205             


Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile 
    210                 215                 220                 


Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser 
225                 230                 235                 240 


Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn 
                245                 250                 255     


Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu 
            260                 265                 270         


Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg 
        275                 280                 285             


Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr 
    290                 295                 300                 


Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp 
305                 310                 315                 320 


Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp 
                325                 330                 335     


Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr 
            340                 345                 350         


His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu 
        355                 360                 365             


Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His 
    370                 375                 380                 


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
385                 390                 395                 400 


Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val 
                405                 410                 415     


Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu 
            420                 425                 430         


Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val 
        435                 440                 445             


Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys 
    450                 455                 460                 


Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu 
465                 470                 475                 480 


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys 
                485                 490                 495     


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp 
            500                 505                 510         


Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg 
        515                 520                 525             


Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser 
    530                 535                 540                 


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu 
545                 550                 555                 560 


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu 
                565                 570                 575     


Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln 
            580                 585                 590         


Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln 
        595                 600                 605             


Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser 
    610                 615                 620                 


Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys 
625                 630                 635                 640 


Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile 
                645                 650                 655     


Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu 
            660                 665                 670         


Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
        675                 680                 685         


<210>  109
<211>  2695
<212>  DNA
<213>  Homo sapiens

<400>  109
acagacagcg gcagagatct tgggctgagg ttcccgggcg ggcgggcgcg gagagacgcg       60

ggaagcaggg gctgggcggg ggtcgcggcg ccgcagctag cgcagccagc ccgagggccg      120

ccgccgccgc cgcccagcgc gctccggggc cgccggccgc agccagcacc cgccgcgccg      180

cagctccggg accggccccg gccgccgccg ccgcgatggg caacgccgcc gccgccaaga      240

agggcagcga gcaggagagc gtgaaagaat tcttagccaa agccaaagaa gattttctta      300

aaaaatggga aagtcccgct cagaacacag cccacttgga tcagtttgaa cgaatcaaga      360

ccctcggcac gggctccttc gggcgggtga tgctggtgaa acacaaggag accgggaacc      420

actatgccat gaagatcctc gacaaacaga aggtggtgaa actgaaacag atcgaacaca      480

ccctgaatga aaagcgcatc ctgcaagctg tcaactttcc gttcctcgtc aaactcgagt      540

tctccttcaa ggacaactca aacttataca tggtcatgga gtacgtgccc ggcggggaga      600

tgttctcaca cctacggcgg atcggaaggt tcagtgagcc ccatgcccgt ttctacgcgg      660

cccagatcgt cctgaccttt gagtatctgc actcgctgga tctcatctac agggacctga      720

agccggagaa tctgctcatt gaccagcagg gctacattca ggtgacagac ttcggtttcg      780

ccaagcgcgt gaagggccgc acttggacct tgtgcggcac ccctgagtac ctggcccctg      840

agattatcct gagcaaaggc tacaacaagg ccgtggactg gtgggccctg ggggttctta      900

tctatgaaat ggccgctggc tacccgccct tcttcgcaga ccagcccatc cagatctatg      960

agaagatcgt ctctgggaag gtgcgcttcc cttcccactt cagctctgac ttgaaggacc     1020

tgctgcggaa cctcctgcag gtagatctca ccaagcgctt tgggaacctc aagaatgggg     1080

tcaacgatat caagaaccac aagtggtttg ccacaactga ctggattgcc atctaccaga     1140

ggaaggtgga agctcccttc ataccaaagt ttaaaggccc tggggatacg agtaactttg     1200

acgactatga ggaagaagaa atccgggtct ccatcaatga gaagtgtggc aaggagtttt     1260

ctgagtttta ggggcatgcc tgtgccccca tgggttttct tttttctttt ttcttttttt     1320

tggtcggggg ggtgggaggg ttggattgaa cagccagagg gccccagagt tccttgcatc     1380

taatttcacc cccaccccac cctccagggt tagggggagc aggaagccca gataatcaga     1440

gggacagaaa caccagctgc tccccctcat ccccttcacc ctcctgcccc ctctcccact     1500

tttcccttcc tctttcccca cagcccccca gcccctcagc cctcccagcc cacttctgcc     1560

tgttttaaac gagtttctca actccagtca gaccaggtct tgctggtgta tccagggaca     1620

gggtatggaa agaggggctc acgcttaact ccagccccca cccacacccc catcccaccc     1680

aaccacaggc cccacttgct aagggcaaat gaacgaagcg ccaaccttcc tttcggagta     1740

atcctgcctg ggaaggagag atttttagtg acatgttcag tgggttgctt gctagaattt     1800

ttttaaaaaa acaacaattt aaaatcttat ttaagttcca ccagtgcctc cctccctcct     1860

tcctctactc ccacccctcc catgtccccc cattcctcaa atccatttta aagagaagca     1920

gactgacttt ggaaagggag gcgctggggt ttgaacctcc ccgctgctaa tctcccctgg     1980

gcccctcccc ggggaatcct ctctgccaat cctgcgaggg tctaggcccc tttaggaagc     2040

ctccgctctc tttttcccca acagacctgt cttcaccctt gggctttgaa agccagacaa     2100

agcagctgcc cctctccctg ccaaagagga gtcatccccc aaaaagacag agggggagcc     2160

ccaagcccaa gtctttcctc ccagcagcgt ttccccccaa ctccttaatt ttattctccg     2220

ctagatttta acgtccagcc ttccctcagc tgagtgggga gggcatccct gcaaaaggga     2280

acagaagagg ccaagtcccc ccaagccacg gcccggggtt caaggctaga gctgctgggg     2340

aggggctgcc tgttttactc acccaccagc ttccgcctcc cccatcctgg gcgcccctcc     2400

tccagcttag ctgtcagctg tccatcacct ctcccccact ttctcatttg tgcttttttc     2460

tctcgtaata gaaaagtggg gagccgctgg ggagccaccc cattcatccc cgtatttccc     2520

cctctcataa cttctcccca tcccaggagg agttctcagg cctggggtgg ggccccgggt     2580

gggtgcgggg gcgattcaac ctgtgtgctg cgaaggacga gacttcctct tgaacagtgt     2640

gctgttgtaa acatatttga aaactattac caataaagtt ttgtttaaaa aaaaa          2695


<210>  110
<211>  2492
<212>  DNA
<213>  Homo sapiens

<400>  110
accgtagtgc cggtgccctg agaacaggac tgagtgatgg cttccaactc cagcgatgtg       60

aaagaattct tagccaaagc caaagaagat tttcttaaaa aatgggaaag tcccgctcag      120

aacacagccc acttggatca gtttgaacga atcaagaccc tcggcacggg ctccttcggg      180

cgggtgatgc tggtgaaaca caaggagacc gggaaccact atgccatgaa gatcctcgac      240

aaacagaagg tggtgaaact gaaacagatc gaacacaccc tgaatgaaaa gcgcatcctg      300

caagctgtca actttccgtt cctcgtcaaa ctcgagttct ccttcaagga caactcaaac      360

ttatacatgg tcatggagta cgtgcccggc ggggagatgt tctcacacct acggcggatc      420

ggaaggttca gtgagcccca tgcccgtttc tacgcggccc agatcgtcct gacctttgag      480

tatctgcact cgctggatct catctacagg gacctgaagc cggagaatct gctcattgac      540

cagcagggct acattcaggt gacagacttc ggtttcgcca agcgcgtgaa gggccgcact      600

tggaccttgt gcggcacccc tgagtacctg gcccctgaga ttatcctgag caaaggctac      660

aacaaggccg tggactggtg ggccctgggg gttcttatct atgaaatggc cgctggctac      720

ccgcccttct tcgcagacca gcccatccag atctatgaga agatcgtctc tgggaaggtg      780

cgcttccctt cccacttcag ctctgacttg aaggacctgc tgcggaacct cctgcaggta      840

gatctcacca agcgctttgg gaacctcaag aatggggtca acgatatcaa gaaccacaag      900

tggtttgcca caactgactg gattgccatc taccagagga aggtggaagc tcccttcata      960

ccaaagttta aaggccctgg ggatacgagt aactttgacg actatgagga agaagaaatc     1020

cgggtctcca tcaatgagaa gtgtggcaag gagttttctg agttttaggg gcatgcctgt     1080

gcccccatgg gttttctttt ttcttttttc ttttttttgg tcgggggggt gggagggttg     1140

gattgaacag ccagagggcc ccagagttcc ttgcatctaa tttcaccccc accccaccct     1200

ccagggttag ggggagcagg aagcccagat aatcagaggg acagaaacac cagctgctcc     1260

ccctcatccc cttcaccctc ctgccccctc tcccactttt cccttcctct ttccccacag     1320

ccccccagcc cctcagccct cccagcccac ttctgcctgt tttaaacgag tttctcaact     1380

ccagtcagac caggtcttgc tggtgtatcc agggacaggg tatggaaaga ggggctcacg     1440

cttaactcca gcccccaccc acacccccat cccacccaac cacaggcccc acttgctaag     1500

ggcaaatgaa cgaagcgcca accttccttt cggagtaatc ctgcctggga aggagagatt     1560

tttagtgaca tgttcagtgg gttgcttgct agaatttttt taaaaaaaca acaatttaaa     1620

atcttattta agttccacca gtgcctccct ccctccttcc tctactccca cccctcccat     1680

gtccccccat tcctcaaatc cattttaaag agaagcagac tgactttgga aagggaggcg     1740

ctggggtttg aacctccccg ctgctaatct cccctgggcc cctccccggg gaatcctctc     1800

tgccaatcct gcgagggtct aggccccttt aggaagcctc cgctctcttt ttccccaaca     1860

gacctgtctt cacccttggg ctttgaaagc cagacaaagc agctgcccct ctccctgcca     1920

aagaggagtc atcccccaaa aagacagagg gggagcccca agcccaagtc tttcctccca     1980

gcagcgtttc cccccaactc cttaatttta ttctccgcta gattttaacg tccagccttc     2040

cctcagctga gtggggaggg catccctgca aaagggaaca gaagaggcca agtcccccca     2100

agccacggcc cggggttcaa ggctagagct gctggggagg ggctgcctgt tttactcacc     2160

caccagcttc cgcctccccc atcctgggcg cccctcctcc agcttagctg tcagctgtcc     2220

atcacctctc ccccactttc tcatttgtgc ttttttctct cgtaatagaa aagtggggag     2280

ccgctgggga gccaccccat tcatccccgt atttccccct ctcataactt ctccccatcc     2340

caggaggagt tctcaggcct ggggtggggc cccgggtggg tgcgggggcg attcaacctg     2400

tgtgctgcga aggacgagac ttcctcttga acagtgtgct gttgtaaaca tatttgaaaa     2460

ctattaccaa taaagttttg tttaaaaaaa aa                                   2492


<210>  111
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Gly Asn Ala Ala Ala Ala Lys Lys Gly Ser Glu Gln Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Ser Pro Ala Gln Asn Thr Ala His Leu Asp Gln Phe Glu Arg Ile Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Glu Thr Gly Asn His Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Lys Leu Glu Phe Ser Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


Gln Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Asn Asp Ile Lys Asn His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Lys 
305                 310                 315                 320 


Gly Pro Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile 
                325                 330                 335     


Arg Val Ser Ile Asn Glu Lys Cys Gly Lys Glu Phe Ser Glu Phe 
            340                 345                 350     


<210>  112
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Ser Asn Ser Ser Asp Val Lys Glu Phe Leu Ala Lys Ala Lys 
1               5                   10                  15      


Glu Asp Phe Leu Lys Lys Trp Glu Ser Pro Ala Gln Asn Thr Ala His 
            20                  25                  30          


Leu Asp Gln Phe Glu Arg Ile Lys Thr Leu Gly Thr Gly Ser Phe Gly 
        35                  40                  45              


Arg Val Met Leu Val Lys His Lys Glu Thr Gly Asn His Tyr Ala Met 
    50                  55                  60                  


Lys Ile Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His 
65                  70                  75                  80  


Thr Leu Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu 
                85                  90                  95      


Val Lys Leu Glu Phe Ser Phe Lys Asp Asn Ser Asn Leu Tyr Met Val 
            100                 105                 110         


Met Glu Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile 
        115                 120                 125             


Gly Arg Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val 
    130                 135                 140                 


Leu Thr Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu 
145                 150                 155                 160 


Lys Pro Glu Asn Leu Leu Ile Asp Gln Gln Gly Tyr Ile Gln Val Thr 
                165                 170                 175     


Asp Phe Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys 
            180                 185                 190         


Gly Thr Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr 
        195                 200                 205             


Asn Lys Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met 
    210                 215                 220                 


Ala Ala Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr 
225                 230                 235                 240 


Glu Lys Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser 
                245                 250                 255     


Asp Leu Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys 
            260                 265                 270         


Arg Phe Gly Asn Leu Lys Asn Gly Val Asn Asp Ile Lys Asn His Lys 
        275                 280                 285             


Trp Phe Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu 
    290                 295                 300                 


Ala Pro Phe Ile Pro Lys Phe Lys Gly Pro Gly Asp Thr Ser Asn Phe 
305                 310                 315                 320 


Asp Asp Tyr Glu Glu Glu Glu Ile Arg Val Ser Ile Asn Glu Lys Cys 
                325                 330                 335     


Gly Lys Glu Phe Ser Glu Phe 
            340             


<210>  113
<211>  4616
<212>  DNA
<213>  Homo sapiens

<400>  113
tgcgaagata cagtcgggcc agggcctggc ctgggcgcgc ggctgcccgg gggcgcgcag       60

agagggcgga ccgcgcgaag ggggagtgtc tgcccgccgc cgccactgct gctgccaccg      120

ccgtcgccgc cgccgccgcc gccgccgctg ctgctgccgg tgctaaggag ttcgctggag      180

ccctttcctc agacccggcc cggtcttcgc gcccggactc ctggcgccag cgctaggcgc      240

actcaccgct ctgacgggtg cagacgcggg agttgtccca gactgtggag tggcgggcac      300

ggccccagcc ccccttccct tccctgaccc cttcttgcca tcgccccaga catggggaac      360

gcggcgaccg ccaagaaagg cagcgaggtg gagagcgtga aagagtttct agccaaagcc      420

aaagaagact ttttgaaaaa atgggagaat ccaactcaga ataatgccgg acttgaagat      480

tttgaaagga aaaaaaccct tggaacaggt tcatttggaa gagtcatgtt ggtaaaacac      540

aaagccactg aacagtatta tgccatgaag atcttagata agcagaaggt tgttaaactg      600

aagcaaatag agcatacttt gaatgagaaa agaatattac aggcagtgaa ttttcctttc      660

cttgttcgac tggagtatgc ttttaaggat aattctaatt tatacatggt tatggaatat      720

gtccctgggg gtgaaatgtt ttcacatcta agaagaattg gaaggttcag tgagccccat      780

gcacggttct atgcagctca gatagtgcta acattcgagt acctccattc actagacctc      840

atctacagag atctaaaacc tgaaaatctc ttaattgacc atcaaggcta tatccaggtc      900

acagactttg ggtttgccaa aagagttaaa ggcagaactt ggacattatg tggaactcca      960

gagtatttgg ctccagaaat aattctcagc aagggctaca ataaggcagt ggattggtgg     1020

gcattaggag tgctaatcta tgaaatggca gctggctatc ccccattctt tgcagaccaa     1080

ccaattcaga tttatgaaaa gattgtttct ggaaaggtcc gattcccatc ccacttcagt     1140

tcagatctca aggaccttct acggaacctg ctgcaggtgg atttgaccaa gagatttgga     1200

aatctaaaga atggtgtcag tgatataaaa actcacaagt ggtttgccac gacagattgg     1260

attgctattt accagaggaa ggttgaagct ccattcatac caaagtttag aggctctgga     1320

gataccagca actttgatga ctatgaagaa gaagatatcc gtgtctctat aacagaaaaa     1380

tgtgcaaaag aatttggtga attttaaaga ggaacaagat gacatctgag ctcacactca     1440

gtgtttgcac tctgttgaga gataaggtag agctgagacc gtccttgttg aagcagttac     1500

ctagttcctt cattccaacg actgagtgag gtctttattg ccatcatccc gtgtgcgcac     1560

tctgcatcca cctatgtaac aaggcaccgc taagcaagca ttgtctgtgc cataacacag     1620

tactagacca ctttcttact tctctttggg ttgtctttct cctctcctat atccatttct     1680

tccttttcca atttcattgg ttttctctaa acagtgctcc attttatttt gttggtgttt     1740

cagatgggca gtgttatggc tacgtgatat ttgaagggaa ggataagtgt tgctttcagt     1800

agttattgcc aatattgttg ttggtcaatg gcttgaagat aaactttcta ataattatta     1860

tttctttgag tagctcagac ttggttttgc caaaactctt ggtaattttt gaagatagac     1920

tgtcttatca ccaaggaaat ttatacaaat taagactaac tttcttggaa ttcactattc     1980

tggcaataaa ttttggtaga ctaatacagt acagctagac ccagaaattt ggaaggctgt     2040

agatcagagg ttctagttcc ctttccctcc ttttatatcc tcctctcctt gagtaatgaa     2100

gtgaccagcc tgtgtagtgt gacaaacgtg tctcattcag caggaaaaac taatgatatg     2160

gatcatcacc cagattctct cacttggtac cagcatttct gtaggtatta gagaagagtt     2220

ctaagttttc taaaccttaa ctgttcctta aggattttag ccagtatttt aatagaacat     2280

gattaatgaa agtgacaaat tttaaatttt ctctaatagt cctcatcata aactttttaa     2340

aggaaaataa gcaaactaaa aagaacattg gtttagataa atacttatac tttgcaaagt     2400

caaaaatggc ttgatttttg gaaacaatat agaggtattc atatttaaat gagggtttac     2460

atttgttttg ttttgtaacc gttaaaaaga agttgtttcc agctaattat tgtggtgtac     2520

tatatttgtg agcctagggt aggggcactg ctgcaacttc tgctttcatc ccatgcctca     2580

tcaatgagga aagggaacaa agtgtataaa actgccacaa ttgtatttta attttgaggt     2640

atgatatttt cagatatttc ataatttcta acctctgttc tctcagtaaa cagaatgtct     2700

gatcgatcat gcagatacaa tgttggtatt tgagaggtta gtttttttcc tacacttttt     2760

tttgccaact gacttaacaa cattgctgtc aggtggaaat ttcaagcact tttgcacatt     2820

tagttcagtg tttgttgaga atccatggct taacccactt gttttgctat ttttttcttt     2880

gcttttaatt ttccccatct gattttatct ctgcgtttca gtgacctacc ttaaaacaac     2940

acacgagaag agttaaactg ggttcatttt aatgatcaat ttacctgcat ataaaattta     3000

tttttaatca agctgatctt aatgtatata atcattctat ttgctttatt atcggtgcag     3060

gtaggtcatt aacaccactt cttttcatct gtaccacacc ctggtgaaac ctttgaagac     3120

ataaaaaaaa cctgtctgag atgttctttc taccaatcta tatgtctttc ggttatcaag     3180

tgtttctgca tggtaatgtc atgtaaatgc tgatattgat ttcactggtc catctatatt     3240

taaaacgtgc aagaaaaaaa taaaatactc tgctctagca agttttgtgt aacaaaggca     3300

tatcgtcatg ttaataaatt taaaacatca ttcgtataaa atattttaat tttcttgtat     3360

ttcatttaga cccaagaaca tgctgaccaa tgtgttctat atgtaaacta caaattctat     3420

ggtagctttg ttgtatatta ttgtaaaatt attttaataa gtcatgggga tgacaatttg     3480

attattacaa tttagttttc agtaatcaaa aagatttcta tgaattctaa aaaatatttt     3540

tttctatgaa attactagtg cccagctgta gaatctacct taggtagatg atccctagac     3600

atacgttggt tttgagggct attcagccat tccattttac tctctattta aaggccgtga     3660

gcaagcttgt catgagcaaa tatgtcaagg gagtcaattt ctgaccaatc aagtacacta     3720

aattagaata tttttaaagt atgtaacatt cccagtttca gccacaattt agccaagaat     3780

aagataaaaa cttgaataag aagtaagtag cataaatcag tatttaacct aaaattacat     3840

atttgaaaca gaagatatta tgttatgctc agtaaataat taagagatgg cattgtgtaa     3900

gaaggagccc tagactgaaa gtcaagacat ctgaatttca ggctggaaaa ctatcagtat     3960

gatctcagcc tcagttctct tgtctgtaaa atggaagaac tggattaggc agtttgtaag     4020

attcctccta actttcacag tcgatgacaa gattgtcttt ttatctgata ttttgaaggg     4080

tatattgctt tgaagtaagt ctcaataagg caatatattt tagggcatct ttcttcttat     4140

ctctgacagt gttcttaaaa ttatttgaat atcataagag ccttggtgtc tgtcctaatt     4200

cctttctcac tcaccgatgc tgaataccca gttgaatcaa actgtcaacc taccaaaaac     4260

gatattgtgg cttatgggta ttgctgtctc attcttggta tattcttgtg ttaactgccc     4320

attggcctga aaatactcat tgtaagcctg aaaaaaaaaa tctttcccac tgttttttct     4380

gcttgttgta agaatcaaat gaaataatgt atgtgaaagc accttgtaaa ctgtaaccta     4440

tcaatgtaaa atgttaaggt gtgttgttat ttcattaatt acttctttgt ttagaatgga     4500

atttcctatg cactactgta gctaggaaat gctgaaaaca actgtgtttt ttaattaatc     4560

aataactgca aaattaaagt accttcaatg gataagacaa aaaaaaaaaa aaaaaa         4616


<210>  114
<211>  4481
<212>  DNA
<213>  Homo sapiens

<400>  114
acatgcatag ctcttagctt ctgtgtaaga agttgtgagc tccttctgga aacatttgca       60

gttacattaa gtaaagtgta aatgcacatg aatggcagct tatagagaac caccttgtaa      120

ccagtataca ggtacaacta cagctcttca gaaattggaa ggttttgcta gccggttatt      180

tcatagacac tctaaaggta ctgcacatga tcagaaaaca gctctggaaa atgacagcct      240

tcatttctct gaacatactg ccttatggga cagatcaatg aaagagtttc tagccaaagc      300

caaagaagac tttttgaaaa aatgggagaa tccaactcag aataatgccg gacttgaaga      360

ttttgaaagg aaaaaaaccc ttggaacagg ttcatttgga agagtcatgt tggtaaaaca      420

caaagccact gaacagtatt atgccatgaa gatcttagat aagcagaagg ttgttaaact      480

gaagcaaata gagcatactt tgaatgagaa aagaatatta caggcagtga attttccttt      540

ccttgttcga ctggagtatg cttttaagga taattctaat ttatacatgg ttatggaata      600

tgtccctggg ggtgaaatgt tttcacatct aagaagaatt ggaaggttca gtgagcccca      660

tgcacggttc tatgcagctc agatagtgct aacattcgag tacctccatt cactagacct      720

catctacaga gatctaaaac ctgaaaatct cttaattgac catcaaggct atatccaggt      780

cacagacttt gggtttgcca aaagagttaa aggcagaact tggacattat gtggaactcc      840

agagtatttg gctccagaaa taattctcag caagggctac aataaggcag tggattggtg      900

ggcattagga gtgctaatct atgaaatggc agctggctat cccccattct ttgcagacca      960

accaattcag atttatgaaa agattgtttc tggaaaggtc cgattcccat cccacttcag     1020

ttcagatctc aaggaccttc tacggaacct gctgcaggtg gatttgacca agagatttgg     1080

aaatctaaag aatggtgtca gtgatataaa aactcacaag tggtttgcca cgacagattg     1140

gattgctatt taccagagga aggttgaagc tccattcata ccaaagttta gaggctctgg     1200

agataccagc aactttgatg actatgaaga agaagatatc cgtgtctcta taacagaaaa     1260

atgtgcaaaa gaatttggtg aattttaaag aggaacaaga tgacatctga gctcacactc     1320

agtgtttgca ctctgttgag agataaggta gagctgagac cgtccttgtt gaagcagtta     1380

cctagttcct tcattccaac gactgagtga ggtctttatt gccatcatcc cgtgtgcgca     1440

ctctgcatcc acctatgtaa caaggcaccg ctaagcaagc attgtctgtg ccataacaca     1500

gtactagacc actttcttac ttctctttgg gttgtctttc tcctctccta tatccatttc     1560

ttccttttcc aatttcattg gttttctcta aacagtgctc cattttattt tgttggtgtt     1620

tcagatgggc agtgttatgg ctacgtgata tttgaaggga aggataagtg ttgctttcag     1680

tagttattgc caatattgtt gttggtcaat ggcttgaaga taaactttct aataattatt     1740

atttctttga gtagctcaga cttggttttg ccaaaactct tggtaatttt tgaagataga     1800

ctgtcttatc accaaggaaa tttatacaaa ttaagactaa ctttcttgga attcactatt     1860

ctggcaataa attttggtag actaatacag tacagctaga cccagaaatt tggaaggctg     1920

tagatcagag gttctagttc cctttccctc cttttatatc ctcctctcct tgagtaatga     1980

agtgaccagc ctgtgtagtg tgacaaacgt gtctcattca gcaggaaaaa ctaatgatat     2040

ggatcatcac ccagattctc tcacttggta ccagcatttc tgtaggtatt agagaagagt     2100

tctaagtttt ctaaacctta actgttcctt aaggatttta gccagtattt taatagaaca     2160

tgattaatga aagtgacaaa ttttaaattt tctctaatag tcctcatcat aaacttttta     2220

aaggaaaata agcaaactaa aaagaacatt ggtttagata aatacttata ctttgcaaag     2280

tcaaaaatgg cttgattttt ggaaacaata tagaggtatt catatttaaa tgagggttta     2340

catttgtttt gttttgtaac cgttaaaaag aagttgtttc cagctaatta ttgtggtgta     2400

ctatatttgt gagcctaggg taggggcact gctgcaactt ctgctttcat cccatgcctc     2460

atcaatgagg aaagggaaca aagtgtataa aactgccaca attgtatttt aattttgagg     2520

tatgatattt tcagatattt cataatttct aacctctgtt ctctcagtaa acagaatgtc     2580

tgatcgatca tgcagataca atgttggtat ttgagaggtt agtttttttc ctacactttt     2640

ttttgccaac tgacttaaca acattgctgt caggtggaaa tttcaagcac ttttgcacat     2700

ttagttcagt gtttgttgag aatccatggc ttaacccact tgttttgcta tttttttctt     2760

tgcttttaat tttccccatc tgattttatc tctgcgtttc agtgacctac cttaaaacaa     2820

cacacgagaa gagttaaact gggttcattt taatgatcaa tttacctgca tataaaattt     2880

atttttaatc aagctgatct taatgtatat aatcattcta tttgctttat tatcggtgca     2940

ggtaggtcat taacaccact tcttttcatc tgtaccacac cctggtgaaa cctttgaaga     3000

cataaaaaaa acctgtctga gatgttcttt ctaccaatct atatgtcttt cggttatcaa     3060

gtgtttctgc atggtaatgt catgtaaatg ctgatattga tttcactggt ccatctatat     3120

ttaaaacgtg caagaaaaaa ataaaatact ctgctctagc aagttttgtg taacaaaggc     3180

atatcgtcat gttaataaat ttaaaacatc attcgtataa aatattttaa ttttcttgta     3240

tttcatttag acccaagaac atgctgacca atgtgttcta tatgtaaact acaaattcta     3300

tggtagcttt gttgtatatt attgtaaaat tattttaata agtcatgggg atgacaattt     3360

gattattaca atttagtttt cagtaatcaa aaagatttct atgaattcta aaaaatattt     3420

ttttctatga aattactagt gcccagctgt agaatctacc ttaggtagat gatccctaga     3480

catacgttgg ttttgagggc tattcagcca ttccatttta ctctctattt aaaggccgtg     3540

agcaagcttg tcatgagcaa atatgtcaag ggagtcaatt tctgaccaat caagtacact     3600

aaattagaat atttttaaag tatgtaacat tcccagtttc agccacaatt tagccaagaa     3660

taagataaaa acttgaataa gaagtaagta gcataaatca gtatttaacc taaaattaca     3720

tatttgaaac agaagatatt atgttatgct cagtaaataa ttaagagatg gcattgtgta     3780

agaaggagcc ctagactgaa agtcaagaca tctgaatttc aggctggaaa actatcagta     3840

tgatctcagc ctcagttctc ttgtctgtaa aatggaagaa ctggattagg cagtttgtaa     3900

gattcctcct aactttcaca gtcgatgaca agattgtctt tttatctgat attttgaagg     3960

gtatattgct ttgaagtaag tctcaataag gcaatatatt ttagggcatc tttcttctta     4020

tctctgacag tgttcttaaa attatttgaa tatcataaga gccttggtgt ctgtcctaat     4080

tcctttctca ctcaccgatg ctgaataccc agttgaatca aactgtcaac ctaccaaaaa     4140

cgatattgtg gcttatgggt attgctgtct cattcttggt atattcttgt gttaactgcc     4200

cattggcctg aaaatactca ttgtaagcct gaaaaaaaaa atctttccca ctgttttttc     4260

tgcttgttgt aagaatcaaa tgaaataatg tatgtgaaag caccttgtaa actgtaacct     4320

atcaatgtaa aatgttaagg tgtgttgtta tttcattaat tacttctttg tttagaatgg     4380

aatttcctat gcactactgt agctaggaaa tgctgaaaac aactgtgttt tttaattaat     4440

caataactgc aaaattaaag taccttcaat ggataagaca a                         4481


<210>  115
<211>  4650
<212>  DNA
<213>  Homo sapiens

<400>  115
atgctgatat aattgagaac atcttataca tcctggttcg aacattttct ccctgccatt       60

ttgagttgtt ctagtggtat atgaaggagg ctgggataac tagcttgaaa gaaattcagt      120

ctagttatag acatctttgg cattaatctg atgtttacta gtgatatctc atgctaggca      180

gttatgcttt gcttctaggg gcttctcttt ttaaaacaaa agaaagctct tttcgttttc      240

tgtgtgctgc atgctccagt gtgtgtgttt acaccatcgg ttcttctccc tctagagatt      300

agcataactc cctttgctgt tggattgtta ttttgagcaa tatgttttgg aaaggttggt      360

tttcatcatg agtgcacgca aatcatcaga tgcatctgct tgctcctctt cagaaatatc      420

tgattccttt gtgaaagagt ttctagccaa agccaaagaa gactttttga aaaaatggga      480

gaatccaact cagaataatg ccggacttga agattttgaa aggaaaaaaa cccttggaac      540

aggttcattt ggaagagtca tgttggtaaa acacaaagcc actgaacagt attatgccat      600

gaagatctta gataagcaga aggttgttaa actgaagcaa atagagcata ctttgaatga      660

gaaaagaata ttacaggcag tgaattttcc tttccttgtt cgactggagt atgcttttaa      720

ggataattct aatttataca tggttatgga atatgtccct gggggtgaaa tgttttcaca      780

tctaagaaga attggaaggt tcagtgagcc ccatgcacgg ttctatgcag ctcagatagt      840

gctaacattc gagtacctcc attcactaga cctcatctac agagatctaa aacctgaaaa      900

tctcttaatt gaccatcaag gctatatcca ggtcacagac tttgggtttg ccaaaagagt      960

taaaggcaga acttggacat tatgtggaac tccagagtat ttggctccag aaataattct     1020

cagcaagggc tacaataagg cagtggattg gtgggcatta ggagtgctaa tctatgaaat     1080

ggcagctggc tatcccccat tctttgcaga ccaaccaatt cagatttatg aaaagattgt     1140

ttctggaaag gtccgattcc catcccactt cagttcagat ctcaaggacc ttctacggaa     1200

cctgctgcag gtggatttga ccaagagatt tggaaatcta aagaatggtg tcagtgatat     1260

aaaaactcac aagtggtttg ccacgacaga ttggattgct atttaccaga ggaaggttga     1320

agctccattc ataccaaagt ttagaggctc tggagatacc agcaactttg atgactatga     1380

agaagaagat atccgtgtct ctataacaga aaaatgtgca aaagaatttg gtgaatttta     1440

aagaggaaca agatgacatc tgagctcaca ctcagtgttt gcactctgtt gagagataag     1500

gtagagctga gaccgtcctt gttgaagcag ttacctagtt ccttcattcc aacgactgag     1560

tgaggtcttt attgccatca tcccgtgtgc gcactctgca tccacctatg taacaaggca     1620

ccgctaagca agcattgtct gtgccataac acagtactag accactttct tacttctctt     1680

tgggttgtct ttctcctctc ctatatccat ttcttccttt tccaatttca ttggttttct     1740

ctaaacagtg ctccatttta ttttgttggt gtttcagatg ggcagtgtta tggctacgtg     1800

atatttgaag ggaaggataa gtgttgcttt cagtagttat tgccaatatt gttgttggtc     1860

aatggcttga agataaactt tctaataatt attatttctt tgagtagctc agacttggtt     1920

ttgccaaaac tcttggtaat ttttgaagat agactgtctt atcaccaagg aaatttatac     1980

aaattaagac taactttctt ggaattcact attctggcaa taaattttgg tagactaata     2040

cagtacagct agacccagaa atttggaagg ctgtagatca gaggttctag ttccctttcc     2100

ctccttttat atcctcctct ccttgagtaa tgaagtgacc agcctgtgta gtgtgacaaa     2160

cgtgtctcat tcagcaggaa aaactaatga tatggatcat cacccagatt ctctcacttg     2220

gtaccagcat ttctgtaggt attagagaag agttctaagt tttctaaacc ttaactgttc     2280

cttaaggatt ttagccagta ttttaataga acatgattaa tgaaagtgac aaattttaaa     2340

ttttctctaa tagtcctcat cataaacttt ttaaaggaaa ataagcaaac taaaaagaac     2400

attggtttag ataaatactt atactttgca aagtcaaaaa tggcttgatt tttggaaaca     2460

atatagaggt attcatattt aaatgagggt ttacatttgt tttgttttgt aaccgttaaa     2520

aagaagttgt ttccagctaa ttattgtggt gtactatatt tgtgagccta gggtaggggc     2580

actgctgcaa cttctgcttt catcccatgc ctcatcaatg aggaaaggga acaaagtgta     2640

taaaactgcc acaattgtat tttaattttg aggtatgata ttttcagata tttcataatt     2700

tctaacctct gttctctcag taaacagaat gtctgatcga tcatgcagat acaatgttgg     2760

tatttgagag gttagttttt ttcctacact tttttttgcc aactgactta acaacattgc     2820

tgtcaggtgg aaatttcaag cacttttgca catttagttc agtgtttgtt gagaatccat     2880

ggcttaaccc acttgttttg ctattttttt ctttgctttt aattttcccc atctgatttt     2940

atctctgcgt ttcagtgacc taccttaaaa caacacacga gaagagttaa actgggttca     3000

ttttaatgat caatttacct gcatataaaa tttattttta atcaagctga tcttaatgta     3060

tataatcatt ctatttgctt tattatcggt gcaggtaggt cattaacacc acttcttttc     3120

atctgtacca caccctggtg aaacctttga agacataaaa aaaacctgtc tgagatgttc     3180

tttctaccaa tctatatgtc tttcggttat caagtgtttc tgcatggtaa tgtcatgtaa     3240

atgctgatat tgatttcact ggtccatcta tatttaaaac gtgcaagaaa aaaataaaat     3300

actctgctct agcaagtttt gtgtaacaaa ggcatatcgt catgttaata aatttaaaac     3360

atcattcgta taaaatattt taattttctt gtatttcatt tagacccaag aacatgctga     3420

ccaatgtgtt ctatatgtaa actacaaatt ctatggtagc tttgttgtat attattgtaa     3480

aattatttta ataagtcatg gggatgacaa tttgattatt acaatttagt tttcagtaat     3540

caaaaagatt tctatgaatt ctaaaaaata tttttttcta tgaaattact agtgcccagc     3600

tgtagaatct accttaggta gatgatccct agacatacgt tggttttgag ggctattcag     3660

ccattccatt ttactctcta tttaaaggcc gtgagcaagc ttgtcatgag caaatatgtc     3720

aagggagtca atttctgacc aatcaagtac actaaattag aatattttta aagtatgtaa     3780

cattcccagt ttcagccaca atttagccaa gaataagata aaaacttgaa taagaagtaa     3840

gtagcataaa tcagtattta acctaaaatt acatatttga aacagaagat attatgttat     3900

gctcagtaaa taattaagag atggcattgt gtaagaagga gccctagact gaaagtcaag     3960

acatctgaat ttcaggctgg aaaactatca gtatgatctc agcctcagtt ctcttgtctg     4020

taaaatggaa gaactggatt aggcagtttg taagattcct cctaactttc acagtcgatg     4080

acaagattgt ctttttatct gatattttga agggtatatt gctttgaagt aagtctcaat     4140

aaggcaatat attttagggc atctttcttc ttatctctga cagtgttctt aaaattattt     4200

gaatatcata agagccttgg tgtctgtcct aattcctttc tcactcaccg atgctgaata     4260

cccagttgaa tcaaactgtc aacctaccaa aaacgatatt gtggcttatg ggtattgctg     4320

tctcattctt ggtatattct tgtgttaact gcccattggc ctgaaaatac tcattgtaag     4380

cctgaaaaaa aaaatctttc ccactgtttt ttctgcttgt tgtaagaatc aaatgaaata     4440

atgtatgtga aagcaccttg taaactgtaa cctatcaatg taaaatgtta aggtgtgttg     4500

ttatttcatt aattacttct ttgtttagaa tggaatttcc tatgcactac tgtagctagg     4560

aaatgctgaa aacaactgtg ttttttaatt aatcaataac tgcaaaatta aagtaccttc     4620

aatggataag acaaaaaaaa aaaaaaaaaa                                      4650


<210>  116
<211>  4506
<212>  DNA
<213>  Homo sapiens

<400>  116
taacacagaa tgtttaaatg gttaacattt gtgctgcagt atagctttct ggctcatgaa       60

aaatgaaagc tatcagcgat ctcggcaata agattcatcg ccaatagtca ctagcaacag      120

cacacagcat tttaatatca gtgaggtcca cagctagcag taagagctgg tgtaattgaa      180

agacgtttag gtgcaatcat tctgctgttt gctccttgcc aggttcaaca tgggattgtc      240

acgcaaatca tcagatgcat ctgcttgctc ctcttcagaa atatctgtga aagagtttct      300

agccaaagcc aaagaagact ttttgaaaaa atgggagaat ccaactcaga ataatgccgg      360

acttgaagat tttgaaagga aaaaaaccct tggaacaggt tcatttggaa gagtcatgtt      420

ggtaaaacac aaagccactg aacagtatta tgccatgaag atcttagata agcagaaggt      480

tgttaaactg aagcaaatag agcatacttt gaatgagaaa agaatattac aggcagtgaa      540

ttttcctttc cttgttcgac tggagtatgc ttttaaggat aattctaatt tatacatggt      600

tatggaatat gtccctgggg gtgaaatgtt ttcacatcta agaagaattg gaaggttcag      660

tgagccccat gcacggttct atgcagctca gatagtgcta acattcgagt acctccattc      720

actagacctc atctacagag atctaaaacc tgaaaatctc ttaattgacc atcaaggcta      780

tatccaggtc acagactttg ggtttgccaa aagagttaaa ggcagaactt ggacattatg      840

tggaactcca gagtatttgg ctccagaaat aattctcagc aagggctaca ataaggcagt      900

ggattggtgg gcattaggag tgctaatcta tgaaatggca gctggctatc ccccattctt      960

tgcagaccaa ccaattcaga tttatgaaaa gattgtttct ggaaaggtcc gattcccatc     1020

ccacttcagt tcagatctca aggaccttct acggaacctg ctgcaggtgg atttgaccaa     1080

gagatttgga aatctaaaga atggtgtcag tgatataaaa actcacaagt ggtttgccac     1140

gacagattgg attgctattt accagaggaa ggttgaagct ccattcatac caaagtttag     1200

aggctctgga gataccagca actttgatga ctatgaagaa gaagatatcc gtgtctctat     1260

aacagaaaaa tgtgcaaaag aatttggtga attttaaaga ggaacaagat gacatctgag     1320

ctcacactca gtgtttgcac tctgttgaga gataaggtag agctgagacc gtccttgttg     1380

aagcagttac ctagttcctt cattccaacg actgagtgag gtctttattg ccatcatccc     1440

gtgtgcgcac tctgcatcca cctatgtaac aaggcaccgc taagcaagca ttgtctgtgc     1500

cataacacag tactagacca ctttcttact tctctttggg ttgtctttct cctctcctat     1560

atccatttct tccttttcca atttcattgg ttttctctaa acagtgctcc attttatttt     1620

gttggtgttt cagatgggca gtgttatggc tacgtgatat ttgaagggaa ggataagtgt     1680

tgctttcagt agttattgcc aatattgttg ttggtcaatg gcttgaagat aaactttcta     1740

ataattatta tttctttgag tagctcagac ttggttttgc caaaactctt ggtaattttt     1800

gaagatagac tgtcttatca ccaaggaaat ttatacaaat taagactaac tttcttggaa     1860

ttcactattc tggcaataaa ttttggtaga ctaatacagt acagctagac ccagaaattt     1920

ggaaggctgt agatcagagg ttctagttcc ctttccctcc ttttatatcc tcctctcctt     1980

gagtaatgaa gtgaccagcc tgtgtagtgt gacaaacgtg tctcattcag caggaaaaac     2040

taatgatatg gatcatcacc cagattctct cacttggtac cagcatttct gtaggtatta     2100

gagaagagtt ctaagttttc taaaccttaa ctgttcctta aggattttag ccagtatttt     2160

aatagaacat gattaatgaa agtgacaaat tttaaatttt ctctaatagt cctcatcata     2220

aactttttaa aggaaaataa gcaaactaaa aagaacattg gtttagataa atacttatac     2280

tttgcaaagt caaaaatggc ttgatttttg gaaacaatat agaggtattc atatttaaat     2340

gagggtttac atttgttttg ttttgtaacc gttaaaaaga agttgtttcc agctaattat     2400

tgtggtgtac tatatttgtg agcctagggt aggggcactg ctgcaacttc tgctttcatc     2460

ccatgcctca tcaatgagga aagggaacaa agtgtataaa actgccacaa ttgtatttta     2520

attttgaggt atgatatttt cagatatttc ataatttcta acctctgttc tctcagtaaa     2580

cagaatgtct gatcgatcat gcagatacaa tgttggtatt tgagaggtta gtttttttcc     2640

tacacttttt tttgccaact gacttaacaa cattgctgtc aggtggaaat ttcaagcact     2700

tttgcacatt tagttcagtg tttgttgaga atccatggct taacccactt gttttgctat     2760

ttttttcttt gcttttaatt ttccccatct gattttatct ctgcgtttca gtgacctacc     2820

ttaaaacaac acacgagaag agttaaactg ggttcatttt aatgatcaat ttacctgcat     2880

ataaaattta tttttaatca agctgatctt aatgtatata atcattctat ttgctttatt     2940

atcggtgcag gtaggtcatt aacaccactt cttttcatct gtaccacacc ctggtgaaac     3000

ctttgaagac ataaaaaaaa cctgtctgag atgttctttc taccaatcta tatgtctttc     3060

ggttatcaag tgtttctgca tggtaatgtc atgtaaatgc tgatattgat ttcactggtc     3120

catctatatt taaaacgtgc aagaaaaaaa taaaatactc tgctctagca agttttgtgt     3180

aacaaaggca tatcgtcatg ttaataaatt taaaacatca ttcgtataaa atattttaat     3240

tttcttgtat ttcatttaga cccaagaaca tgctgaccaa tgtgttctat atgtaaacta     3300

caaattctat ggtagctttg ttgtatatta ttgtaaaatt attttaataa gtcatgggga     3360

tgacaatttg attattacaa tttagttttc agtaatcaaa aagatttcta tgaattctaa     3420

aaaatatttt tttctatgaa attactagtg cccagctgta gaatctacct taggtagatg     3480

atccctagac atacgttggt tttgagggct attcagccat tccattttac tctctattta     3540

aaggccgtga gcaagcttgt catgagcaaa tatgtcaagg gagtcaattt ctgaccaatc     3600

aagtacacta aattagaata tttttaaagt atgtaacatt cccagtttca gccacaattt     3660

agccaagaat aagataaaaa cttgaataag aagtaagtag cataaatcag tatttaacct     3720

aaaattacat atttgaaaca gaagatatta tgttatgctc agtaaataat taagagatgg     3780

cattgtgtaa gaaggagccc tagactgaaa gtcaagacat ctgaatttca ggctggaaaa     3840

ctatcagtat gatctcagcc tcagttctct tgtctgtaaa atggaagaac tggattaggc     3900

agtttgtaag attcctccta actttcacag tcgatgacaa gattgtcttt ttatctgata     3960

ttttgaaggg tatattgctt tgaagtaagt ctcaataagg caatatattt tagggcatct     4020

ttcttcttat ctctgacagt gttcttaaaa ttatttgaat atcataagag ccttggtgtc     4080

tgtcctaatt cctttctcac tcaccgatgc tgaataccca gttgaatcaa actgtcaacc     4140

taccaaaaac gatattgtgg cttatgggta ttgctgtctc attcttggta tattcttgtg     4200

ttaactgccc attggcctga aaatactcat tgtaagcctg aaaaaaaaaa tctttcccac     4260

tgttttttct gcttgttgta agaatcaaat gaaataatgt atgtgaaagc accttgtaaa     4320

ctgtaaccta tcaatgtaaa atgttaaggt gtgttgttat ttcattaatt acttctttgt     4380

ttagaatgga atttcctatg cactactgta gctaggaaat gctgaaaaca actgtgtttt     4440

ttaattaatc aataactgca aaattaaagt accttcaatg gataagacaa aaaaaaaaaa     4500

aaaaaa                                                                4506


<210>  117
<211>  4458
<212>  DNA
<213>  Homo sapiens

<400>  117
taacacagaa tgtttaaatg gttaacattt gtgctgcagt atagctttct ggctcatgaa       60

aaatgaaagc tatcagcgat ctcggcaata agattcatcg ccaatagtca ctagcaacag      120

cacacagcat tttaatatca gtgaggtcca cagctagcag taagagctgg tgtaattgaa      180

agacgtttag gtgcaatcat tctgctgttt gctccttgcc aggttcaaca tgggattgtt      240

gaaagagttt ctagccaaag ccaaagaaga ctttttgaaa aaatgggaga atccaactca      300

gaataatgcc ggacttgaag attttgaaag gaaaaaaacc cttggaacag gttcatttgg      360

aagagtcatg ttggtaaaac acaaagccac tgaacagtat tatgccatga agatcttaga      420

taagcagaag gttgttaaac tgaagcaaat agagcatact ttgaatgaga aaagaatatt      480

acaggcagtg aattttcctt tccttgttcg actggagtat gcttttaagg ataattctaa      540

tttatacatg gttatggaat atgtccctgg gggtgaaatg ttttcacatc taagaagaat      600

tggaaggttc agtgagcccc atgcacggtt ctatgcagct cagatagtgc taacattcga      660

gtacctccat tcactagacc tcatctacag agatctaaaa cctgaaaatc tcttaattga      720

ccatcaaggc tatatccagg tcacagactt tgggtttgcc aaaagagtta aaggcagaac      780

ttggacatta tgtggaactc cagagtattt ggctccagaa ataattctca gcaagggcta      840

caataaggca gtggattggt gggcattagg agtgctaatc tatgaaatgg cagctggcta      900

tcccccattc tttgcagacc aaccaattca gatttatgaa aagattgttt ctggaaaggt      960

ccgattccca tcccacttca gttcagatct caaggacctt ctacggaacc tgctgcaggt     1020

ggatttgacc aagagatttg gaaatctaaa gaatggtgtc agtgatataa aaactcacaa     1080

gtggtttgcc acgacagatt ggattgctat ttaccagagg aaggttgaag ctccattcat     1140

accaaagttt agaggctctg gagataccag caactttgat gactatgaag aagaagatat     1200

ccgtgtctct ataacagaaa aatgtgcaaa agaatttggt gaattttaaa gaggaacaag     1260

atgacatctg agctcacact cagtgtttgc actctgttga gagataaggt agagctgaga     1320

ccgtccttgt tgaagcagtt acctagttcc ttcattccaa cgactgagtg aggtctttat     1380

tgccatcatc ccgtgtgcgc actctgcatc cacctatgta acaaggcacc gctaagcaag     1440

cattgtctgt gccataacac agtactagac cactttctta cttctctttg ggttgtcttt     1500

ctcctctcct atatccattt cttccttttc caatttcatt ggttttctct aaacagtgct     1560

ccattttatt ttgttggtgt ttcagatggg cagtgttatg gctacgtgat atttgaaggg     1620

aaggataagt gttgctttca gtagttattg ccaatattgt tgttggtcaa tggcttgaag     1680

ataaactttc taataattat tatttctttg agtagctcag acttggtttt gccaaaactc     1740

ttggtaattt ttgaagatag actgtcttat caccaaggaa atttatacaa attaagacta     1800

actttcttgg aattcactat tctggcaata aattttggta gactaataca gtacagctag     1860

acccagaaat ttggaaggct gtagatcaga ggttctagtt ccctttccct ccttttatat     1920

cctcctctcc ttgagtaatg aagtgaccag cctgtgtagt gtgacaaacg tgtctcattc     1980

agcaggaaaa actaatgata tggatcatca cccagattct ctcacttggt accagcattt     2040

ctgtaggtat tagagaagag ttctaagttt tctaaacctt aactgttcct taaggatttt     2100

agccagtatt ttaatagaac atgattaatg aaagtgacaa attttaaatt ttctctaata     2160

gtcctcatca taaacttttt aaaggaaaat aagcaaacta aaaagaacat tggtttagat     2220

aaatacttat actttgcaaa gtcaaaaatg gcttgatttt tggaaacaat atagaggtat     2280

tcatatttaa atgagggttt acatttgttt tgttttgtaa ccgttaaaaa gaagttgttt     2340

ccagctaatt attgtggtgt actatatttg tgagcctagg gtaggggcac tgctgcaact     2400

tctgctttca tcccatgcct catcaatgag gaaagggaac aaagtgtata aaactgccac     2460

aattgtattt taattttgag gtatgatatt ttcagatatt tcataatttc taacctctgt     2520

tctctcagta aacagaatgt ctgatcgatc atgcagatac aatgttggta tttgagaggt     2580

tagttttttt cctacacttt tttttgccaa ctgacttaac aacattgctg tcaggtggaa     2640

atttcaagca cttttgcaca tttagttcag tgtttgttga gaatccatgg cttaacccac     2700

ttgttttgct atttttttct ttgcttttaa ttttccccat ctgattttat ctctgcgttt     2760

cagtgaccta ccttaaaaca acacacgaga agagttaaac tgggttcatt ttaatgatca     2820

atttacctgc atataaaatt tatttttaat caagctgatc ttaatgtata taatcattct     2880

atttgcttta ttatcggtgc aggtaggtca ttaacaccac ttcttttcat ctgtaccaca     2940

ccctggtgaa acctttgaag acataaaaaa aacctgtctg agatgttctt tctaccaatc     3000

tatatgtctt tcggttatca agtgtttctg catggtaatg tcatgtaaat gctgatattg     3060

atttcactgg tccatctata tttaaaacgt gcaagaaaaa aataaaatac tctgctctag     3120

caagttttgt gtaacaaagg catatcgtca tgttaataaa tttaaaacat cattcgtata     3180

aaatatttta attttcttgt atttcattta gacccaagaa catgctgacc aatgtgttct     3240

atatgtaaac tacaaattct atggtagctt tgttgtatat tattgtaaaa ttattttaat     3300

aagtcatggg gatgacaatt tgattattac aatttagttt tcagtaatca aaaagatttc     3360

tatgaattct aaaaaatatt tttttctatg aaattactag tgcccagctg tagaatctac     3420

cttaggtaga tgatccctag acatacgttg gttttgaggg ctattcagcc attccatttt     3480

actctctatt taaaggccgt gagcaagctt gtcatgagca aatatgtcaa gggagtcaat     3540

ttctgaccaa tcaagtacac taaattagaa tatttttaaa gtatgtaaca ttcccagttt     3600

cagccacaat ttagccaaga ataagataaa aacttgaata agaagtaagt agcataaatc     3660

agtatttaac ctaaaattac atatttgaaa cagaagatat tatgttatgc tcagtaaata     3720

attaagagat ggcattgtgt aagaaggagc cctagactga aagtcaagac atctgaattt     3780

caggctggaa aactatcagt atgatctcag cctcagttct cttgtctgta aaatggaaga     3840

actggattag gcagtttgta agattcctcc taactttcac agtcgatgac aagattgtct     3900

ttttatctga tattttgaag ggtatattgc tttgaagtaa gtctcaataa ggcaatatat     3960

tttagggcat ctttcttctt atctctgaca gtgttcttaa aattatttga atatcataag     4020

agccttggtg tctgtcctaa ttcctttctc actcaccgat gctgaatacc cagttgaatc     4080

aaactgtcaa cctaccaaaa acgatattgt ggcttatggg tattgctgtc tcattcttgg     4140

tatattcttg tgttaactgc ccattggcct gaaaatactc attgtaagcc tgaaaaaaaa     4200

aatctttccc actgtttttt ctgcttgttg taagaatcaa atgaaataat gtatgtgaaa     4260

gcaccttgta aactgtaacc tatcaatgta aaatgttaag gtgtgttgtt atttcattaa     4320

ttacttcttt gtttagaatg gaatttccta tgcactactg tagctaggaa atgctgaaaa     4380

caactgtgtt ttttaattaa tcaataactg caaaattaaa gtaccttcaa tggataagac     4440

aaaaaaaaaa aaaaaaaa                                                   4458


<210>  118
<211>  4254
<212>  DNA
<213>  Homo sapiens

<400>  118
taaagagaga aagccactag gctctctcat gctgctacta tctagttcta taagcttata       60

taaagacaga aatgaagcaa gactgatttc ttcacagaat aatgccggac ttgaagattt      120

tgaaaggaaa aaaacccttg gaacaggttc atttggaaga gtcatgttgg taaaacacaa      180

agccactgaa cagtattatg ccatgaagat cttagataag cagaaggttg ttaaactgaa      240

gcaaatagag catactttga atgagaaaag aatattacag gcagtgaatt ttcctttcct      300

tgttcgactg gagtatgctt ttaaggataa ttctaattta tacatggtta tggaatatgt      360

ccctgggggt gaaatgtttt cacatctaag aagaattgga aggttcagtg agccccatgc      420

acggttctat gcagctcaga tagtgctaac attcgagtac ctccattcac tagacctcat      480

ctacagagat ctaaaacctg aaaatctctt aattgaccat caaggctata tccaggtcac      540

agactttggg tttgccaaaa gagttaaagg cagaacttgg acattatgtg gaactccaga      600

gtatttggct ccagaaataa ttctcagcaa gggctacaat aaggcagtgg attggtgggc      660

attaggagtg ctaatctatg aaatggcagc tggctatccc ccattctttg cagaccaacc      720

aattcagatt tatgaaaaga ttgtttctgg aaaggtccga ttcccatccc acttcagttc      780

agatctcaag gaccttctac ggaacctgct gcaggtggat ttgaccaaga gatttggaaa      840

tctaaagaat ggtgtcagtg atataaaaac tcacaagtgg tttgccacga cagattggat      900

tgctatttac cagaggaagg ttgaagctcc attcatacca aagtttagag gctctggaga      960

taccagcaac tttgatgact atgaagaaga agatatccgt gtctctataa cagaaaaatg     1020

tgcaaaagaa tttggtgaat tttaaagagg aacaagatga catctgagct cacactcagt     1080

gtttgcactc tgttgagaga taaggtagag ctgagaccgt ccttgttgaa gcagttacct     1140

agttccttca ttccaacgac tgagtgaggt ctttattgcc atcatcccgt gtgcgcactc     1200

tgcatccacc tatgtaacaa ggcaccgcta agcaagcatt gtctgtgcca taacacagta     1260

ctagaccact ttcttacttc tctttgggtt gtctttctcc tctcctatat ccatttcttc     1320

cttttccaat ttcattggtt ttctctaaac agtgctccat tttattttgt tggtgtttca     1380

gatgggcagt gttatggcta cgtgatattt gaagggaagg ataagtgttg ctttcagtag     1440

ttattgccaa tattgttgtt ggtcaatggc ttgaagataa actttctaat aattattatt     1500

tctttgagta gctcagactt ggttttgcca aaactcttgg taatttttga agatagactg     1560

tcttatcacc aaggaaattt atacaaatta agactaactt tcttggaatt cactattctg     1620

gcaataaatt ttggtagact aatacagtac agctagaccc agaaatttgg aaggctgtag     1680

atcagaggtt ctagttccct ttccctcctt ttatatcctc ctctccttga gtaatgaagt     1740

gaccagcctg tgtagtgtga caaacgtgtc tcattcagca ggaaaaacta atgatatgga     1800

tcatcaccca gattctctca cttggtacca gcatttctgt aggtattaga gaagagttct     1860

aagttttcta aaccttaact gttccttaag gattttagcc agtattttaa tagaacatga     1920

ttaatgaaag tgacaaattt taaattttct ctaatagtcc tcatcataaa ctttttaaag     1980

gaaaataagc aaactaaaaa gaacattggt ttagataaat acttatactt tgcaaagtca     2040

aaaatggctt gatttttgga aacaatatag aggtattcat atttaaatga gggtttacat     2100

ttgttttgtt ttgtaaccgt taaaaagaag ttgtttccag ctaattattg tggtgtacta     2160

tatttgtgag cctagggtag gggcactgct gcaacttctg ctttcatccc atgcctcatc     2220

aatgaggaaa gggaacaaag tgtataaaac tgccacaatt gtattttaat tttgaggtat     2280

gatattttca gatatttcat aatttctaac ctctgttctc tcagtaaaca gaatgtctga     2340

tcgatcatgc agatacaatg ttggtatttg agaggttagt ttttttccta cacttttttt     2400

tgccaactga cttaacaaca ttgctgtcag gtggaaattt caagcacttt tgcacattta     2460

gttcagtgtt tgttgagaat ccatggctta acccacttgt tttgctattt ttttctttgc     2520

ttttaatttt ccccatctga ttttatctct gcgtttcagt gacctacctt aaaacaacac     2580

acgagaagag ttaaactggg ttcattttaa tgatcaattt acctgcatat aaaatttatt     2640

tttaatcaag ctgatcttaa tgtatataat cattctattt gctttattat cggtgcaggt     2700

aggtcattaa caccacttct tttcatctgt accacaccct ggtgaaacct ttgaagacat     2760

aaaaaaaacc tgtctgagat gttctttcta ccaatctata tgtctttcgg ttatcaagtg     2820

tttctgcatg gtaatgtcat gtaaatgctg atattgattt cactggtcca tctatattta     2880

aaacgtgcaa gaaaaaaata aaatactctg ctctagcaag ttttgtgtaa caaaggcata     2940

tcgtcatgtt aataaattta aaacatcatt cgtataaaat attttaattt tcttgtattt     3000

catttagacc caagaacatg ctgaccaatg tgttctatat gtaaactaca aattctatgg     3060

tagctttgtt gtatattatt gtaaaattat tttaataagt catggggatg acaatttgat     3120

tattacaatt tagttttcag taatcaaaaa gatttctatg aattctaaaa aatatttttt     3180

tctatgaaat tactagtgcc cagctgtaga atctacctta ggtagatgat ccctagacat     3240

acgttggttt tgagggctat tcagccattc cattttactc tctatttaaa ggccgtgagc     3300

aagcttgtca tgagcaaata tgtcaaggga gtcaatttct gaccaatcaa gtacactaaa     3360

ttagaatatt tttaaagtat gtaacattcc cagtttcagc cacaatttag ccaagaataa     3420

gataaaaact tgaataagaa gtaagtagca taaatcagta tttaacctaa aattacatat     3480

ttgaaacaga agatattatg ttatgctcag taaataatta agagatggca ttgtgtaaga     3540

aggagcccta gactgaaagt caagacatct gaatttcagg ctggaaaact atcagtatga     3600

tctcagcctc agttctcttg tctgtaaaat ggaagaactg gattaggcag tttgtaagat     3660

tcctcctaac tttcacagtc gatgacaaga ttgtcttttt atctgatatt ttgaagggta     3720

tattgctttg aagtaagtct caataaggca atatatttta gggcatcttt cttcttatct     3780

ctgacagtgt tcttaaaatt atttgaatat cataagagcc ttggtgtctg tcctaattcc     3840

tttctcactc accgatgctg aatacccagt tgaatcaaac tgtcaaccta ccaaaaacga     3900

tattgtggct tatgggtatt gctgtctcat tcttggtata ttcttgtgtt aactgcccat     3960

tggcctgaaa atactcattg taagcctgaa aaaaaaaatc tttcccactg ttttttctgc     4020

ttgttgtaag aatcaaatga aataatgtat gtgaaagcac cttgtaaact gtaacctatc     4080

aatgtaaaat gttaaggtgt gttgttattt cattaattac ttctttgttt agaatggaat     4140

ttcctatgca ctactgtagc taggaaatgc tgaaaacaac tgtgtttttt aattaatcaa     4200

taactgcaaa attaaagtac cttcaatgga taagacaaaa aaaaaaaaaa aaaa           4254


<210>  119
<211>  4542
<212>  DNA
<213>  Homo sapiens

<400>  119
atgctgatat aattgagaac atcttataca tcctggttcg aacattttct ccctgccatt       60

ttgagttgtt ctagtggtat atgaaggagg ctgggataac tagcttgaaa gaaattcagt      120

ctagttatag acatctttgg cattaatctg atgtttacta gtgatatctc atgctaggca      180

gttatgcttt gcttctaggg gcttctcttt ttaaaacaaa agaaagctct tttcgttttc      240

tgtgtgctgc atgctccagt gtgtgtgttt acaccatcgg ttcttctccc tctagagatt      300

agcataactc cctttgctgt tggattgtta ttttgagcaa tatgttttgg aaaggttggt      360

tttcatcatg agtgcacgca aatcatcaga tgcatctgct tgctcctctt cagaaatatc      420

tgtgaaagag tttctagcca aagccaaaga agactttttg aaaaaatggg agaatccaac      480

tcagaataat gccggacttg aagattttga aaggaaaaaa acccttggaa caggttcatt      540

tggaagagtc atgttggtaa aacacaaagc cactgaacag tattatgcca tgaagatctt      600

agataagcag aaggataatt ctaatttata catggttatg gaatatgtcc ctgggggtga      660

aatgttttca catctaagaa gaattggaag gttcagtgag ccccatgcac ggttctatgc      720

agctcagata gtgctaacat tcgagtacct ccattcacta gacctcatct acagagatct      780

aaaacctgaa aatctcttaa ttgaccatca aggctatatc caggtcacag actttgggtt      840

tgccaaaaga gttaaaggca gaacttggac attatgtgga actccagagt atttggctcc      900

agaaataatt ctcagcaagg gctacaataa ggcagtggat tggtgggcat taggagtgct      960

aatctatgaa atggcagctg gctatccccc attctttgca gaccaaccaa ttcagattta     1020

tgaaaagatt gtttctggaa aggtccgatt cccatcccac ttcagttcag atctcaagga     1080

ccttctacgg aacctgctgc aggtggattt gaccaagaga tttggaaatc taaagaatgg     1140

tgtcagtgat ataaaaactc acaagtggtt tgccacgaca gattggattg ctatttacca     1200

gaggaaggtt gaagctccat tcataccaaa gtttagaggc tctggagata ccagcaactt     1260

tgatgactat gaagaagaag atatccgtgt ctctataaca gaaaaatgtg caaaagaatt     1320

tggtgaattt taaagaggaa caagatgaca tctgagctca cactcagtgt ttgcactctg     1380

ttgagagata aggtagagct gagaccgtcc ttgttgaagc agttacctag ttccttcatt     1440

ccaacgactg agtgaggtct ttattgccat catcccgtgt gcgcactctg catccaccta     1500

tgtaacaagg caccgctaag caagcattgt ctgtgccata acacagtact agaccacttt     1560

cttacttctc tttgggttgt ctttctcctc tcctatatcc atttcttcct tttccaattt     1620

cattggtttt ctctaaacag tgctccattt tattttgttg gtgtttcaga tgggcagtgt     1680

tatggctacg tgatatttga agggaaggat aagtgttgct ttcagtagtt attgccaata     1740

ttgttgttgg tcaatggctt gaagataaac tttctaataa ttattatttc tttgagtagc     1800

tcagacttgg ttttgccaaa actcttggta atttttgaag atagactgtc ttatcaccaa     1860

ggaaatttat acaaattaag actaactttc ttggaattca ctattctggc aataaatttt     1920

ggtagactaa tacagtacag ctagacccag aaatttggaa ggctgtagat cagaggttct     1980

agttcccttt ccctcctttt atatcctcct ctccttgagt aatgaagtga ccagcctgtg     2040

tagtgtgaca aacgtgtctc attcagcagg aaaaactaat gatatggatc atcacccaga     2100

ttctctcact tggtaccagc atttctgtag gtattagaga agagttctaa gttttctaaa     2160

ccttaactgt tccttaagga ttttagccag tattttaata gaacatgatt aatgaaagtg     2220

acaaatttta aattttctct aatagtcctc atcataaact ttttaaagga aaataagcaa     2280

actaaaaaga acattggttt agataaatac ttatactttg caaagtcaaa aatggcttga     2340

tttttggaaa caatatagag gtattcatat ttaaatgagg gtttacattt gttttgtttt     2400

gtaaccgtta aaaagaagtt gtttccagct aattattgtg gtgtactata tttgtgagcc     2460

tagggtaggg gcactgctgc aacttctgct ttcatcccat gcctcatcaa tgaggaaagg     2520

gaacaaagtg tataaaactg ccacaattgt attttaattt tgaggtatga tattttcaga     2580

tatttcataa tttctaacct ctgttctctc agtaaacaga atgtctgatc gatcatgcag     2640

atacaatgtt ggtatttgag aggttagttt ttttcctaca cttttttttg ccaactgact     2700

taacaacatt gctgtcaggt ggaaatttca agcacttttg cacatttagt tcagtgtttg     2760

ttgagaatcc atggcttaac ccacttgttt tgctattttt ttctttgctt ttaattttcc     2820

ccatctgatt ttatctctgc gtttcagtga cctaccttaa aacaacacac gagaagagtt     2880

aaactgggtt cattttaatg atcaatttac ctgcatataa aatttatttt taatcaagct     2940

gatcttaatg tatataatca ttctatttgc tttattatcg gtgcaggtag gtcattaaca     3000

ccacttcttt tcatctgtac cacaccctgg tgaaaccttt gaagacataa aaaaaacctg     3060

tctgagatgt tctttctacc aatctatatg tctttcggtt atcaagtgtt tctgcatggt     3120

aatgtcatgt aaatgctgat attgatttca ctggtccatc tatatttaaa acgtgcaaga     3180

aaaaaataaa atactctgct ctagcaagtt ttgtgtaaca aaggcatatc gtcatgttaa     3240

taaatttaaa acatcattcg tataaaatat tttaattttc ttgtatttca tttagaccca     3300

agaacatgct gaccaatgtg ttctatatgt aaactacaaa ttctatggta gctttgttgt     3360

atattattgt aaaattattt taataagtca tggggatgac aatttgatta ttacaattta     3420

gttttcagta atcaaaaaga tttctatgaa ttctaaaaaa tatttttttc tatgaaatta     3480

ctagtgccca gctgtagaat ctaccttagg tagatgatcc ctagacatac gttggttttg     3540

agggctattc agccattcca ttttactctc tatttaaagg ccgtgagcaa gcttgtcatg     3600

agcaaatatg tcaagggagt caatttctga ccaatcaagt acactaaatt agaatatttt     3660

taaagtatgt aacattccca gtttcagcca caatttagcc aagaataaga taaaaacttg     3720

aataagaagt aagtagcata aatcagtatt taacctaaaa ttacatattt gaaacagaag     3780

atattatgtt atgctcagta aataattaag agatggcatt gtgtaagaag gagccctaga     3840

ctgaaagtca agacatctga atttcaggct ggaaaactat cagtatgatc tcagcctcag     3900

ttctcttgtc tgtaaaatgg aagaactgga ttaggcagtt tgtaagattc ctcctaactt     3960

tcacagtcga tgacaagatt gtctttttat ctgatatttt gaagggtata ttgctttgaa     4020

gtaagtctca ataaggcaat atattttagg gcatctttct tcttatctct gacagtgttc     4080

ttaaaattat ttgaatatca taagagcctt ggtgtctgtc ctaattcctt tctcactcac     4140

cgatgctgaa tacccagttg aatcaaactg tcaacctacc aaaaacgata ttgtggctta     4200

tgggtattgc tgtctcattc ttggtatatt cttgtgttaa ctgcccattg gcctgaaaat     4260

actcattgta agcctgaaaa aaaaaatctt tcccactgtt ttttctgctt gttgtaagaa     4320

tcaaatgaaa taatgtatgt gaaagcacct tgtaaactgt aacctatcaa tgtaaaatgt     4380

taaggtgtgt tgttatttca ttaattactt ctttgtttag aatggaattt cctatgcact     4440

actgtagcta ggaaatgctg aaaacaactg tgttttttaa ttaatcaata actgcaaaat     4500

taaagtacct tcaatggata agacaaaaaa aaaaaaaaaa aa                        4542


<210>  120
<211>  2055
<212>  DNA
<213>  Homo sapiens

<400>  120
gccattttga gttgttctag tggtatatga aggaggctgg gataactagc ttgaaagaaa       60

ttcagtctag ttatagacat ctttggcatt aatctgatgt ttactagtga tatctcatgc      120

taggcagtta tgctttgctt ctaggggctt ctctttttaa aacaaaagaa agctcttttc      180

gttttctgtg tgctgcatgc tccagtgtgt gtgtttacac catcggttct tctccctcta      240

gagattagca taactccctt tgctgttgga ttgttatttt gagcaatatg ttttggaaag      300

gttggttttc atcatgagtg cacgcaaatc atcagatgca tctgcttgct cctcttcaga      360

aatatctgat tcctttgtga aagagtttct agccaaagcc aaagaagact ttttgaaaaa      420

atgggagaat ccaactcaga ataatgccgg acttgaagat tttgaaagga aaaaaaccct      480

tggaacaggt tcatttggaa gagtcatgtt ggtaaaacac aaagccactg aacagtatta      540

tgccatgaag atcttagata agcagaaggt tgttaaactg aagcaaatag agcatacttt      600

gaatgagaaa agaatattac aggcagtgaa ttttcctttc cttgttcgac tggagtatgc      660

ttttaaggat aattctaatt tatacatggt tatggaatat gtccctgggg gtgaaatgtt      720

ttcacatcta agaagaattg gaaggttcag tgagccccat gcacggttct atgcagctca      780

gatagtgcta acattcgagt acctccattc actagacctc atctacagag atctaaaacc      840

tgaaaatctc ttaattgacc atcaaggcta tatccaggtc acagactttg ggtttgccaa      900

aagagttaaa ggcagaactt ggacattatg tggaactcca gagtatttgg ctccagaaat      960

aattctcagc aagggctaca ataaggcagt ggattggtgg gcattaggag tgctaatcta     1020

tgaaatggca gctggctatc ccccattctt tgcagaccaa ccaattcaga tttatgaaaa     1080

gattgtttct ggaaagcaga acttttgata tgaacaaaac aaaactttga gaaaaattaa     1140

cagacaaggc agtgatttat ttttgaagaa tttgagaagt gtagactctc aagaggacta     1200

aaggtcatat gaagaatgat gagagaacca aaatacatta aaatcacaaa tggaagaaga     1260

atattttact aatacaaaaa ctaagaatgt aaatgttata ataattgttt caaatcattt     1320

aattgacagt aattataaag ttcttgaatc tttactatat tacttttatt tatattcata     1380

taagaaatcc aattttctaa caaggatact gtcataacta aatttacatt tattaagaaa     1440

aactgcttta gttaaaatta atgtgtcttc atttttatgc attggcctcg atttgccaat     1500

cattctctat tggttaaatt ttatattcag ctgtttatga atatatattc attttatatc     1560

aaactttaaa attttgtatc taataatcag catatattct aaaatcataa cagtctaaat     1620

cctgggcacc ttagaagaat gacaccagaa aaccttatta tatcacaata ttctgttttc     1680

cccttcattt atttagaaat atgacaggat atttggtgta cttttgtttt ttaactaaaa     1740

gtaccagatt atctctcccc atgtgggata taaaattatc cccatctctt actcccttta     1800

ctcatctaaa gtagaagtca tgaaagtgga atttttgcca ttaaaaggct ctgtattatg     1860

tgaagttaga ttgtattaac catttcccaa taaatcatct gtttcaaaac tcaaattcaa     1920

actagaatgt gtctctattc acattgcaaa aatattattg tctctctggt tagtggctaa     1980

aagccaaatt ggaaactaac tagtttttta aattttttaa attgtgcaaa ttattaaaaa     2040

tccaatttgg tctta                                                      2055


<210>  121
<211>  1968
<212>  DNA
<213>  Homo sapiens

<400>  121
actgctgctg ccaccgccgt cgccgccgcc gccgccgccg ccgctgctgc tgccggtgct       60

aaggagttcg ctggagccct ttcctcagac ccggcccggt cttcgcgccc ggactcctgg      120

cgccagcgct aggcgcactc accgctctga cgggtgcaga cgcgggagtt gtcccagact      180

gtggagtggc gggcacggcc ccagcccccc ttcccttccc tgaccccttc ttgccatcgc      240

cccagacatg gggaacgcgg cgaccgccaa gaaaggcagc gaggtggaga gcgtgaaaga      300

gtttctagcc aaagccaaag aagacttttt gaaaaaatgg gagaatccaa ctcagaataa      360

tgccggactt gaagattttg aaaggaaaaa aacccttgga acaggttcat ttggaagagt      420

catgttggta aaacacaaag ccactgaaca gtattatgcc atgaagatct tagataagca      480

gaaggttgtt aaactgaagc aaatagagca tactttgaat gagaaaagaa tattacaggc      540

agtgaatttt cctttccttg ttcgactgga gtatgctttt aaggataatt ctaatttata      600

catggttatg gaatatgtcc ctgggggtga aatgttttca catctaagaa gaattggaag      660

gttcagtgag ccccatgcac ggttctatgc agctcagata gtgctaacat tcgagtacct      720

ccattcacta gacctcatct acagagatct aaaacctgaa aatctcttaa ttgaccatca      780

aggctatatc caggtcacag actttgggtt tgccaaaaga gttaaaggca gaacttggac      840

attatgtgga actccagagt atttggctcc agaaataatt ctcagcaagg gctacaataa      900

ggcagtggat tggtgggcat taggagtgct aatctatgaa atggcagctg gctatccccc      960

attctttgca gaccaaccaa ttcagattta tgaaaagatt gtttctggaa agaacttttg     1020

atatgaacaa aacaaaactt tgagaaaaat taacagacaa ggcagtgatt tatttttgaa     1080

gaatttgaga agtgtagact ctcaagagga ctaaaggtca tatgaagaat gatgagagaa     1140

ccaaaataca ttaaaatcac aaatggaaga agaatatttt actaatacaa aaactaagaa     1200

tgtaaatgtt ataataattg tttcaaatca tttaattgac agtaattata aagttcttga     1260

atctttacta tattactttt atttatattc atataagaaa tccaattttc taacaaggat     1320

actgtcataa ctaaatttac atttattaag aaaaactgct ttagttaaaa ttaatgtgtc     1380

ttcattttta tgcattggcc tcgatttgcc aatcattctc tattggttaa attttatatt     1440

cagctgttta tgaatatata ttcattttat atcaaacttt aaaattttgt atctaataat     1500

cagcatatat tctaaaatca taacagtcta aatcctgggc accttagaag aatgacacca     1560

gaaaacctta ttatatcaca atattctgtt ttccccttca tttatttaga aatatgacag     1620

gatatttggt gtacttttgt tttttaacta aaagtaccag attatctctc cccatgtggg     1680

atataaaatt atccccatct cttactccct ttactcatct aaagtagaag tcatgaaagt     1740

ggaatttttg ccattaaaag gctctgtatt atgtgaagtt agattgtatt aaccatttcc     1800

caataaatca tctgtttcaa aactcaaatt caaactagaa tgtgtctcta ttcacattgc     1860

aaaaatatta ttgtctctct ggttagtggc taaaagccaa attggaaact aactagtttt     1920

ttaaattttt taaattgtgc aaattattaa aaatccaatt tggtctta                  1968


<210>  122
<211>  4515
<212>  DNA
<213>  Homo sapiens

<400>  122
taacacagaa tgtttaaatg gttaacattt gtgctgcagt atagctttct ggctcatgaa       60

aaatgaaagc tatcagcgat ctcggcaata agattcatcg ccaatagtca ctagcaacag      120

cacacagcat tttaatatca gtgaggtcca cagctagcag taagagctgg tgtaattgaa      180

agacgtttag gtgcaatcat tctgctgttt gctccttgcc aggttcaaca tgggattgtc      240

acgcaaatca tcagatgcat ctgcttgctc ctcttcagaa atatctgatt cctttgtgaa      300

agagtttcta gccaaagcca aagaagactt tttgaaaaaa tgggagaatc caactcagaa      360

taatgccgga cttgaagatt ttgaaaggaa aaaaaccctt ggaacaggtt catttggaag      420

agtcatgttg gtaaaacaca aagccactga acagtattat gccatgaaga tcttagataa      480

gcagaaggtt gttaaactga agcaaataga gcatactttg aatgagaaaa gaatattaca      540

ggcagtgaat tttcctttcc ttgttcgact ggagtatgct tttaaggata attctaattt      600

atacatggtt atggaatatg tccctggggg tgaaatgttt tcacatctaa gaagaattgg      660

aaggttcagt gagccccatg cacggttcta tgcagctcag atagtgctaa cattcgagta      720

cctccattca ctagacctca tctacagaga tctaaaacct gaaaatctct taattgacca      780

tcaaggctat atccaggtca cagactttgg gtttgccaaa agagttaaag gcagaacttg      840

gacattatgt ggaactccag agtatttggc tccagaaata attctcagca agggctacaa      900

taaggcagtg gattggtggg cattaggagt gctaatctat gaaatggcag ctggctatcc      960

cccattcttt gcagaccaac caattcagat ttatgaaaag attgtttctg gaaaggtccg     1020

attcccatcc cacttcagtt cagatctcaa ggaccttcta cggaacctgc tgcaggtgga     1080

tttgaccaag agatttggaa atctaaagaa tggtgtcagt gatataaaaa ctcacaagtg     1140

gtttgccacg acagattgga ttgctattta ccagaggaag gttgaagctc cattcatacc     1200

aaagtttaga ggctctggag ataccagcaa ctttgatgac tatgaagaag aagatatccg     1260

tgtctctata acagaaaaat gtgcaaaaga atttggtgaa ttttaaagag gaacaagatg     1320

acatctgagc tcacactcag tgtttgcact ctgttgagag ataaggtaga gctgagaccg     1380

tccttgttga agcagttacc tagttccttc attccaacga ctgagtgagg tctttattgc     1440

catcatcccg tgtgcgcact ctgcatccac ctatgtaaca aggcaccgct aagcaagcat     1500

tgtctgtgcc ataacacagt actagaccac tttcttactt ctctttgggt tgtctttctc     1560

ctctcctata tccatttctt ccttttccaa tttcattggt tttctctaaa cagtgctcca     1620

ttttattttg ttggtgtttc agatgggcag tgttatggct acgtgatatt tgaagggaag     1680

gataagtgtt gctttcagta gttattgcca atattgttgt tggtcaatgg cttgaagata     1740

aactttctaa taattattat ttctttgagt agctcagact tggttttgcc aaaactcttg     1800

gtaatttttg aagatagact gtcttatcac caaggaaatt tatacaaatt aagactaact     1860

ttcttggaat tcactattct ggcaataaat tttggtagac taatacagta cagctagacc     1920

cagaaatttg gaaggctgta gatcagaggt tctagttccc tttccctcct tttatatcct     1980

cctctccttg agtaatgaag tgaccagcct gtgtagtgtg acaaacgtgt ctcattcagc     2040

aggaaaaact aatgatatgg atcatcaccc agattctctc acttggtacc agcatttctg     2100

taggtattag agaagagttc taagttttct aaaccttaac tgttccttaa ggattttagc     2160

cagtatttta atagaacatg attaatgaaa gtgacaaatt ttaaattttc tctaatagtc     2220

ctcatcataa actttttaaa ggaaaataag caaactaaaa agaacattgg tttagataaa     2280

tacttatact ttgcaaagtc aaaaatggct tgatttttgg aaacaatata gaggtattca     2340

tatttaaatg agggtttaca tttgttttgt tttgtaaccg ttaaaaagaa gttgtttcca     2400

gctaattatt gtggtgtact atatttgtga gcctagggta ggggcactgc tgcaacttct     2460

gctttcatcc catgcctcat caatgaggaa agggaacaaa gtgtataaaa ctgccacaat     2520

tgtattttaa ttttgaggta tgatattttc agatatttca taatttctaa cctctgttct     2580

ctcagtaaac agaatgtctg atcgatcatg cagatacaat gttggtattt gagaggttag     2640

tttttttcct acactttttt ttgccaactg acttaacaac attgctgtca ggtggaaatt     2700

tcaagcactt ttgcacattt agttcagtgt ttgttgagaa tccatggctt aacccacttg     2760

ttttgctatt tttttctttg cttttaattt tccccatctg attttatctc tgcgtttcag     2820

tgacctacct taaaacaaca cacgagaaga gttaaactgg gttcatttta atgatcaatt     2880

tacctgcata taaaatttat ttttaatcaa gctgatctta atgtatataa tcattctatt     2940

tgctttatta tcggtgcagg taggtcatta acaccacttc ttttcatctg taccacaccc     3000

tggtgaaacc tttgaagaca taaaaaaaac ctgtctgaga tgttctttct accaatctat     3060

atgtctttcg gttatcaagt gtttctgcat ggtaatgtca tgtaaatgct gatattgatt     3120

tcactggtcc atctatattt aaaacgtgca agaaaaaaat aaaatactct gctctagcaa     3180

gttttgtgta acaaaggcat atcgtcatgt taataaattt aaaacatcat tcgtataaaa     3240

tattttaatt ttcttgtatt tcatttagac ccaagaacat gctgaccaat gtgttctata     3300

tgtaaactac aaattctatg gtagctttgt tgtatattat tgtaaaatta ttttaataag     3360

tcatggggat gacaatttga ttattacaat ttagttttca gtaatcaaaa agatttctat     3420

gaattctaaa aaatattttt ttctatgaaa ttactagtgc ccagctgtag aatctacctt     3480

aggtagatga tccctagaca tacgttggtt ttgagggcta ttcagccatt ccattttact     3540

ctctatttaa aggccgtgag caagcttgtc atgagcaaat atgtcaaggg agtcaatttc     3600

tgaccaatca agtacactaa attagaatat ttttaaagta tgtaacattc ccagtttcag     3660

ccacaattta gccaagaata agataaaaac ttgaataaga agtaagtagc ataaatcagt     3720

atttaaccta aaattacata tttgaaacag aagatattat gttatgctca gtaaataatt     3780

aagagatggc attgtgtaag aaggagccct agactgaaag tcaagacatc tgaatttcag     3840

gctggaaaac tatcagtatg atctcagcct cagttctctt gtctgtaaaa tggaagaact     3900

ggattaggca gtttgtaaga ttcctcctaa ctttcacagt cgatgacaag attgtctttt     3960

tatctgatat tttgaagggt atattgcttt gaagtaagtc tcaataaggc aatatatttt     4020

agggcatctt tcttcttatc tctgacagtg ttcttaaaat tatttgaata tcataagagc     4080

cttggtgtct gtcctaattc ctttctcact caccgatgct gaatacccag ttgaatcaaa     4140

ctgtcaacct accaaaaacg atattgtggc ttatgggtat tgctgtctca ttcttggtat     4200

attcttgtgt taactgccca ttggcctgaa aatactcatt gtaagcctga aaaaaaaaat     4260

ctttcccact gttttttctg cttgttgtaa gaatcaaatg aaataatgta tgtgaaagca     4320

ccttgtaaac tgtaacctat caatgtaaaa tgttaaggtg tgttgttatt tcattaatta     4380

cttctttgtt tagaatggaa tttcctatgc actactgtag ctaggaaatg ctgaaaacaa     4440

ctgtgttttt taattaatca ataactgcaa aattaaagta ccttcaatgg ataagacaaa     4500

aaaaaaaaaa aaaaa                                                      4515


<210>  123
<211>  1793
<212>  DNA
<213>  Homo sapiens

<400>  123
acacagcatt ttaatatcag tgaggtccac agctagcagt aagagctggt gtaattgaaa       60

gacgtttagg tgcaatcatt ctgctgtttg ctccttgcca ggttcaacat gggattgttg      120

aaagagtttc tagccaaagc caaagaagac tttttgaaaa aatgggagaa tccaactcag      180

aataatgccg gacttgaaga ttttgaaagg aaaaaaaccc ttggaacagg ttcatttgga      240

agagtcatgt tggtaaaaca caaagccact gaacagtatt atgccatgaa gatcttagat      300

aagcagaagg ttgttaaact gaagcaaata gagcatactt tgaatgagaa aagaatatta      360

caggcagtga attttccttt ccttgttcga ctggagtatg cttttaagga taattctaat      420

ttatacatgg ttatggaata tgtccctggg ggtgaaatgt tttcacatct aagaagaatt      480

ggaaggttca gtgagcccca tgcacggttc tatgcagctc agatagtgct aacattcgag      540

tacctccatt cactagacct catctacaga gatctaaaac ctgaaaatct cttaattgac      600

catcaaggct atatccaggt cacagacttt gggtttgcca aaagagttaa aggcagaact      660

tggacattat gtggaactcc agagtatttg gctccagaaa taattctcag caagggctac      720

aataaggcag tggattggtg ggcattagga gtgctaatct atgaaatggc agctggctat      780

cccccattct ttgcagacca accaattcag atttatgaaa agattgtttc tggaaagaac      840

ttttgatatg aacaaaacaa aactttgaga aaaattaaca gacaaggcag tgatttattt      900

ttgaagaatt tgagaagtgt agactctcaa gaggactaaa ggtcatatga agaatgatga      960

gagaaccaaa atacattaaa atcacaaatg gaagaagaat attttactaa tacaaaaact     1020

aagaatgtaa atgttataat aattgtttca aatcatttaa ttgacagtaa ttataaagtt     1080

cttgaatctt tactatatta cttttattta tattcatata agaaatccaa ttttctaaca     1140

aggatactgt cataactaaa tttacattta ttaagaaaaa ctgctttagt taaaattaat     1200

gtgtcttcat ttttatgcat tggcctcgat ttgccaatca ttctctattg gttaaatttt     1260

atattcagct gtttatgaat atatattcat tttatatcaa actttaaaat tttgtatcta     1320

ataatcagca tatattctaa aatcataaca gtctaaatcc tgggcacctt agaagaatga     1380

caccagaaaa ccttattata tcacaatatt ctgttttccc cttcatttat ttagaaatat     1440

gacaggatat ttggtgtact tttgtttttt aactaaaagt accagattat ctctccccat     1500

gtgggatata aaattatccc catctcttac tccctttact catctaaagt agaagtcatg     1560

aaagtggaat ttttgccatt aaaaggctct gtattatgtg aagttagatt gtattaacca     1620

tttcccaata aatcatctgt ttcaaaactc aaattcaaac tagaatgtgt ctctattcac     1680

attgcaaaaa tattattgtc tctctggtta gtggctaaaa gccaaattgg aaactaacta     1740

gttttttaaa ttttttaaat tgtgcaaatt attaaaaatc caatttggtc tta            1793


<210>  124
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg 
305                 310                 315                 320 


Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile 
                325                 330                 335     


Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
            340                 345                 350     


<210>  125
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ala Ala Tyr Arg Glu Pro Pro Cys Asn Gln Tyr Thr Gly Thr Thr 
1               5                   10                  15      


Thr Ala Leu Gln Lys Leu Glu Gly Phe Ala Ser Arg Leu Phe His Arg 
            20                  25                  30          


His Ser Lys Gly Thr Ala His Asp Gln Lys Thr Ala Leu Glu Asn Asp 
        35                  40                  45              


Ser Leu His Phe Ser Glu His Thr Ala Leu Trp Asp Arg Ser Met Lys 
    50                  55                  60                  


Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu Asn 
65                  70                  75                  80  


Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys Thr 
                85                  90                  95      


Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys Ala 
            100                 105                 110         


Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val Val 
        115                 120                 125             


Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu Gln 
    130                 135                 140                 


Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys Asp 
145                 150                 155                 160 


Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu Met 
                165                 170                 175     


Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala Arg 
            180                 185                 190         


Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser Leu 
        195                 200                 205             


Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp His 
    210                 215                 220                 


Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val Lys 
225                 230                 235                 240 


Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
                245                 250                 255     


Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala Leu 
            260                 265                 270         


Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe Ala 
        275                 280                 285             


Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val Arg 
    290                 295                 300                 


Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn Leu 
305                 310                 315                 320 


Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly Val 
                325                 330                 335     


Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile Ala 
            340                 345                 350         


Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg Gly 
        355                 360                 365             


Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile Arg 
    370                 375                 380                 


Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
385                 390                 395             


<210>  126
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ser Ala Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser Glu 
1               5                   10                  15      


Ile Ser Asp Ser Phe Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp 
            20                  25                  30          


Phe Leu Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu 
        35                  40                  45              


Asp Phe Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val 
    50                  55                  60                  


Met Leu Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile 
65                  70                  75                  80  


Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu 
                85                  90                  95      


Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg 
            100                 105                 110         


Leu Glu Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu 
        115                 120                 125             


Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg 
    130                 135                 140                 


Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr 
145                 150                 155                 160 


Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro 
                165                 170                 175     


Glu Asn Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe 
            180                 185                 190         


Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr 
        195                 200                 205             


Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys 
    210                 215                 220                 


Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala 
225                 230                 235                 240 


Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys 
                245                 250                 255     


Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu 
            260                 265                 270         


Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe 
        275                 280                 285             


Gly Asn Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe 
    290                 295                 300                 


Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro 
305                 310                 315                 320 


Phe Ile Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp 
                325                 330                 335     


Tyr Glu Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys 
            340                 345                 350         


Glu Phe Gly Glu Phe 
        355         


<210>  127
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Gly Leu Ser Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser 
1               5                   10                  15      


Glu Ile Ser Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu 
            20                  25                  30          


Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe 
        35                  40                  45              


Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu 
    50                  55                  60                  


Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp 
65                  70                  75                  80  


Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu 
                85                  90                  95      


Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu 
            100                 105                 110         


Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val 
        115                 120                 125             


Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser 
    130                 135                 140                 


Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu 
145                 150                 155                 160 


Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
                165                 170                 175     


Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe 
            180                 185                 190         


Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu 
        195                 200                 205             


Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val 
    210                 215                 220                 


Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr 
225                 230                 235                 240 


Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val 
                245                 250                 255     


Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp 
            260                 265                 270         


Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn 
        275                 280                 285             


Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr 
    290                 295                 300                 


Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile 
305                 310                 315                 320 


Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu 
                325                 330                 335     


Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe 
            340                 345                 350         


Gly Glu Phe 
        355 


<210>  128
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Gly Leu Leu Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu 
1               5                   10                  15      


Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe 
            20                  25                  30          


Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu 
        35                  40                  45              


Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp 
    50                  55                  60                  


Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu 
65                  70                  75                  80  


Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu 
                85                  90                  95      


Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val 
            100                 105                 110         


Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser 
        115                 120                 125             


Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu 
    130                 135                 140                 


Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
145                 150                 155                 160 


Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe 
                165                 170                 175     


Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu 
            180                 185                 190         


Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val 
        195                 200                 205             


Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr 
    210                 215                 220                 


Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val 
225                 230                 235                 240 


Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp 
                245                 250                 255     


Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn 
            260                 265                 270         


Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr 
        275                 280                 285             


Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile 
    290                 295                 300                 


Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu 
305                 310                 315                 320 


Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe 
                325                 330                 335     


Gly Glu Phe 
            


<210>  129
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Leu Leu Leu Ser Ser Ser Ile Ser Leu Tyr Lys Asp Arg Asn Glu 
1               5                   10                  15      


Ala Arg Leu Ile Ser Ser Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu 
            20                  25                  30          


Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val 
        35                  40                  45              


Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys 
    50                  55                  60                  


Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys 
65                  70                  75                  80  


Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr 
                85                  90                  95      


Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro 
            100                 105                 110         


Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu 
        115                 120                 125             


Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr 
    130                 135                 140                 


Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu 
145                 150                 155                 160 


Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala 
                165                 170                 175     


Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr 
            180                 185                 190         


Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp 
        195                 200                 205             


Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro 
    210                 215                 220                 


Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser 
225                 230                 235                 240 


Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu 
                245                 250                 255     


Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu 
            260                 265                 270         


Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr 
        275                 280                 285             


Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro 
    290                 295                 300                 


Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu 
305                 310                 315                 320 


Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly 
                325                 330                 335     


Glu Phe 
        


<210>  130
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ser Ala Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser Glu 
1               5                   10                  15      


Ile Ser Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys 
            20                  25                  30          


Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu 
        35                  40                  45              


Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val 
    50                  55                  60                  


Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys 
65                  70                  75                  80  


Gln Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly 
                85                  90                  95      


Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro 
            100                 105                 110         


His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu 
        115                 120                 125             


His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu 
    130                 135                 140                 


Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys 
145                 150                 155                 160 


Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu 
                165                 170                 175     


Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp 
            180                 185                 190         


Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro 
        195                 200                 205             


Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly 
    210                 215                 220                 


Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu 
225                 230                 235                 240 


Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys 
                245                 250                 255     


Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp 
            260                 265                 270         


Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys 
        275                 280                 285             


Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu 
    290                 295                 300                 


Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu 
305                 310                 315                 320 


Phe 
    


<210>  131
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ser Ala Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser Glu 
1               5                   10                  15      


Ile Ser Asp Ser Phe Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp 
            20                  25                  30          


Phe Leu Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu 
        35                  40                  45              


Asp Phe Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val 
    50                  55                  60                  


Met Leu Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile 
65                  70                  75                  80  


Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu 
                85                  90                  95      


Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg 
            100                 105                 110         


Leu Glu Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu 
        115                 120                 125             


Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg 
    130                 135                 140                 


Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr 
145                 150                 155                 160 


Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro 
                165                 170                 175     


Glu Asn Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe 
            180                 185                 190         


Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr 
        195                 200                 205             


Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys 
    210                 215                 220                 


Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala 
225                 230                 235                 240 


Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys 
                245                 250                 255     


Ile Val Ser Gly Lys Gln Asn Phe 
            260                 


<210>  132
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Asn 
                245                 250                 255     


Phe 
    


<210>  133
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Gly Leu Ser Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser 
1               5                   10                  15      


Glu Ile Ser Asp Ser Phe Val Lys Glu Phe Leu Ala Lys Ala Lys Glu 
            20                  25                  30          


Asp Phe Leu Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu 
        35                  40                  45              


Glu Asp Phe Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg 
    50                  55                  60                  


Val Met Leu Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys 
65                  70                  75                  80  


Ile Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr 
                85                  90                  95      


Leu Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val 
            100                 105                 110         


Arg Leu Glu Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met 
        115                 120                 125             


Glu Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly 
    130                 135                 140                 


Arg Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu 
145                 150                 155                 160 


Thr Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys 
                165                 170                 175     


Pro Glu Asn Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp 
            180                 185                 190         


Phe Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly 
        195                 200                 205             


Thr Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn 
    210                 215                 220                 


Lys Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala 
225                 230                 235                 240 


Ala Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu 
                245                 250                 255     


Lys Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp 
            260                 265                 270         


Leu Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg 
        275                 280                 285             


Phe Gly Asn Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp 
    290                 295                 300                 


Phe Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala 
305                 310                 315                 320 


Pro Phe Ile Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp 
                325                 330                 335     


Asp Tyr Glu Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala 
            340                 345                 350         


Lys Glu Phe Gly Glu Phe 
        355             


<210>  134
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Gly Leu Leu Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu 
1               5                   10                  15      


Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe 
            20                  25                  30          


Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu 
        35                  40                  45              


Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp 
    50                  55                  60                  


Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu 
65                  70                  75                  80  


Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu 
                85                  90                  95      


Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val 
            100                 105                 110         


Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser 
        115                 120                 125             


Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu 
    130                 135                 140                 


Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
145                 150                 155                 160 


Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe 
                165                 170                 175     


Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu 
            180                 185                 190         


Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val 
        195                 200                 205             


Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr 
    210                 215                 220                 


Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val 
225                 230                 235                 240 


Ser Gly Lys Asn Phe 
                245 


<210>  135
<211>  5429
<212>  DNA
<213>  Homo sapiens

<400>  135
agaacaactt ttttgacttc ctgcaaagag gacccttaca gtatttttgg agaagttagt       60

aaaaccgaat ctgacatcat cacctagcag ttcatgcagc tagcaagtgg tttgttctta      120

gggtaacaga ggaggaaatt gttcctcgtc tgataagaca acagtggaga aaggacgcat      180

gctgtttctt agggacacgg ctgacttcca gatatgacca tgtatttgtg gcttaaactc      240

ttggcatttg gctttgcctt tctggacaca gaagtatttg tgacagggca aagcccaaca      300

ccttccccca ctggattgac tacagcaaag atgcccagtg ttccactttc aagtgacccc      360

ttacctactc acaccactgc attctcaccc gcaagcacct ttgaaagaga aaatgacttc      420

tcagagacca caacttctct tagtccagac aatacttcca cccaagtatc cccggactct      480

ttggataatg ctagtgcttt taataccaca ggtgtttcat cagtacagac gcctcacctt      540

cccacgcacg cagactcgca gacgccctct gctggaactg acacgcagac attcagcggc      600

tccgccgcca atgcaaaact caaccctacc ccaggcagca atgctatctc agatgtccca      660

ggagagagga gtacagccag cacctttcct acagacccag tttccccatt gacaaccacc      720

ctcagccttg cacaccacag ctctgctgcc ttacctgcac gcacctccaa caccaccatc      780

acagcgaaca cctcagatgc ctaccttaat gcctctgaaa caaccactct gagcccttct      840

ggaagcgctg tcatttcaac cacaacaata gctactactc catctaagcc aacatgtgat      900

gaaaaatatg caaacatcac tgtggattac ttatataaca aggaaactaa attatttaca      960

gcaaagctaa atgttaatga gaatgtggaa tgtggaaaca atacttgcac aaacaatgag     1020

gtgcataacc ttacagaatg taaaaatgcg tctgtttcca tatctcataa ttcatgtact     1080

gctcctgata agacattaat attagatgtg ccaccagggg ttgaaaagtt tcagttacat     1140

gattgtacac aagttgaaaa agcagatact actatttgtt taaaatggaa aaatattgaa     1200

acctttactt gtgatacaca gaatattacc tacagatttc agtgtggtaa tatgatattt     1260

gataataaag aaattaaatt agaaaacctt gaacccgaac atgagtataa gtgtgactca     1320

gaaatactct ataataacca caagtttact aacgcaagta aaattattaa aacagatttt     1380

gggagtccag gagagcctca gattattttt tgtagaagtg aagctgcaca tcaaggagta     1440

attacctgga atccccctca aagatcattt cataatttta ccctctgtta tataaaagag     1500

acagaaaaag attgcctcaa tctggataaa aacctgatca aatatgattt gcaaaattta     1560

aaaccttata cgaaatatgt tttatcatta catgcctaca tcattgcaaa agtgcaacgt     1620

aatggaagtg ctgcaatgtg tcatttcaca actaaaagtg ctcctccaag ccaggtctgg     1680

aacatgactg tctccatgac atcagataat agtatgcatg tcaagtgtag gcctcccagg     1740

gaccgtaatg gcccccatga acgttaccat ttggaagttg aagctggaaa tactctggtt     1800

agaaatgagt cgcataagaa ttgcgatttc cgtgtaaaag atcttcaata ttcaacagac     1860

tacactttta aggcctattt tcacaatgga gactatcctg gagaaccctt tattttacat     1920

cattcaacat cttataattc taaggcactg atagcatttc tggcatttct gattattgtg     1980

acatcaatag ccctgcttgt tgttctctac aaaatctatg atctacataa gaaaagatcc     2040

tgcaatttag atgaacagca ggagcttgtt gaaagggatg atgaaaaaca actgatgaat     2100

gtggagccaa tccatgcaga tattttgttg gaaacttata agaggaagat tgctgatgaa     2160

ggaagacttt ttctggctga atttcagagc atcccgcggg tgttcagcaa gtttcctata     2220

aaggaagctc gaaagccctt taaccagaat aaaaaccgtt atgttgacat tcttccttat     2280

gattataacc gtgttgaact ctctgagata aacggagatg cagggtcaaa ctacataaat     2340

gccagctata ttgatggttt caaagaaccc aggaaataca ttgctgcaca aggtcccagg     2400

gatgaaactg ttgatgattt ctggaggatg atttgggaac agaaagccac agttattgtc     2460

atggtcactc gatgtgaaga aggaaacagg aacaagtgtg cagaatactg gccgtcaatg     2520

gaagagggca ctcgggcttt tggagatgtt gttgtaaaga tcaaccagca caaaagatgt     2580

ccagattaca tcattcagaa attgaacatt gtaaataaaa aagaaaaagc aactggaaga     2640

gaggtgactc acattcagtt caccagctgg ccagaccacg gggtgcctga ggatcctcac     2700

ttgctcctca aactgagaag gagagtgaat gccttcagca atttcttcag tggtcccatt     2760

gtggtgcact gcagtgctgg tgttgggcgc acaggaacct atatcggaat tgatgccatg     2820

ctagaaggcc tggaagccga gaacaaagtg gatgtttatg gttatgttgt caagctaagg     2880

cgacagagat gcctgatggt tcaagtagag gcccagtaca tcttgatcca tcaggctttg     2940

gtggaataca atcagtttgg agaaacagaa gtgaatttgt ctgaattaca tccatatcta     3000

cataacatga agaaaaggga tccacccagt gagccgtctc cactagaggc tgaattccag     3060

agacttcctt catataggag ctggaggaca cagcacattg gaaatcaaga agaaaataaa     3120

agtaaaaaca ggaattctaa tgtcatccca tatgactata acagagtgcc acttaaacat     3180

gagctggaaa tgagtaaaga gagtgagcat gattcagatg aatcctctga tgatgacagt     3240

gattcagagg aaccaagcaa atacatcaat gcatctttta taatgagcta ctggaaacct     3300

gaagtgatga ttgctgctca gggaccactg aaggagacca ttggtgactt ttggcagatg     3360

atcttccaaa gaaaagtcaa agttattgtt atgctgacag aactgaaaca tggagaccag     3420

gaaatctgtg ctcagtactg gggagaagga aagcaaacat atggagatat tgaagttgac     3480

ctgaaagaca cagacaaatc ttcaacttat acccttcgtg tctttgaact gagacattcc     3540

aagaggaaag actctcgaac tgtgtaccag taccaatata caaactggag tgtggagcag     3600

cttcctgcag aacccaagga attaatctct atgattcagg tcgtcaaaca aaaacttccc     3660

cagaagaatt cctctgaagg gaacaagcat cacaagagta cacctctact cattcactgc     3720

agggatggat ctcagcaaac gggaatattt tgtgctttgt taaatctctt agaaagtgcg     3780

gaaacagaag aggtagtgga tatttttcaa gtggtaaaag ctctacgcaa agctaggcca     3840

ggcatggttt ccacattcga gcaatatcaa ttcctatatg acgtcattgc cagcacctac     3900

cctgctcaga atggacaagt aaagaaaaac aaccatcaag aagataaaat tgaatttgat     3960

aatgaagtgg acaaagtaaa gcaggatgct aattgtgtta atccacttgg tgccccagaa     4020

aagctccctg aagcaaagga acaggctgaa ggttctgaac ccacgagtgg cactgagggg     4080

ccagaacatt ctgtcaatgg tcctgcaagt ccagctttaa atcaaggttc ataggaaaag     4140

acataaatga ggaaactcca aacctcctgt tagctgttat ttctattttt gtagaagtag     4200

gaagtgaaaa taggtataca gtggattaat taaatgcagc gaaccaatat ttgtagaagg     4260

gttatatttt actactgtgg aaaaatattt aagatagttt tgccagaaca gtttgtacag     4320

acgtatgctt attttaaaat tttatctctt attcagtaaa aaacaacttc tttgtaatcg     4380

ttatgtgtgt atatgtatgt gtgtatgggt gtgtgtttgt gtgagagaca gagaaagaga     4440

gagaattctt tcaagtgaat ctaaaagctt ttgcttttcc tttgttttta tgaagaaaaa     4500

atacatttta tattagaagt gttaacttag cttgaaggat ctgtttttaa aaatcataaa     4560

ctgtgtgcag actcaataaa atcatgtaca tttctgaaat gacctcaaga tgtcctcctt     4620

gttctactca tatatatcta tcttatatag tttactattt tacttctaga gatagtacat     4680

aaaggtggta tgtgtgtgta tgctactaca aaaaagttgt taactaaatt aacattggga     4740

aatcttatat tccatatatt agcatttagt ccaatgtctt tttaagctta tttaattaaa     4800

aaatttccag tgagcttatc atgctgtctt tacatggggt tttcaatttt gcatgctcga     4860

ttattccctg tacaatattt aaaatttatt gcttgatact tttgacaaca aattaggttt     4920

tgtacaattg aacttaaata aatgtcatta aaataaataa atgcaatatg tattaatatt     4980

cattgtataa aaatagaaga atacaaacat atttgttaaa tatttacata tgaaatttaa     5040

tatagctatt tttatggaat ttttcattga tatgaaaaat atgatattgc atatgcatag     5100

ttcccatgtt aaatcccatt cataactttc attaaagcat ttactttgaa tttctccaat     5160

gcttagaatg tttttaccag gaatggatgt cgctaatcat aataaaattc aaccattatt     5220

tttttcttgt ttataataca ttgtgttata tgttcaaata tgaaatgtgt atgcacctat     5280

tgaaatatgt ttaatgcatt tattaacatt tgcaggacac ttttacaggc cccaattatc     5340

caatagtcta ataattgttt aagatctaga aaaaaaaaat caagaatagt ggtatttttc     5400

atgaagtaat aaaaactcgt tttggtgaa                                       5429


<210>  136
<211>  4946
<212>  DNA
<213>  Homo sapiens

<400>  136
agaacaactt ttttgacttc ctgcaaagag gacccttaca gtatttttgg agaagttagt       60

aaaaccgaat ctgacatcat cacctagcag ttcatgcagc tagcaagtgg tttgttctta      120

gggtaacaga ggaggaaatt gttcctcgtc tgataagaca acagtggaga aaggacgcat      180

gctgtttctt agggacacgg ctgacttcca gatatgacca tgtatttgtg gcttaaactc      240

ttggcatttg gctttgcctt tctggacaca gaagtatttg tgacagggca aagcccaaca      300

ccttccccca ctgatgccta ccttaatgcc tctgaaacaa ccactctgag cccttctgga      360

agcgctgtca tttcaaccac aacaatagct actactccat ctaagccaac atgtgatgaa      420

aaatatgcaa acatcactgt ggattactta tataacaagg aaactaaatt atttacagca      480

aagctaaatg ttaatgagaa tgtggaatgt ggaaacaata cttgcacaaa caatgaggtg      540

cataacctta cagaatgtaa aaatgcgtct gtttccatat ctcataattc atgtactgct      600

cctgataaga cattaatatt agatgtgcca ccaggggttg aaaagtttca gttacatgat      660

tgtacacaag ttgaaaaagc agatactact atttgtttaa aatggaaaaa tattgaaacc      720

tttacttgtg atacacagaa tattacctac agatttcagt gtggtaatat gatatttgat      780

aataaagaaa ttaaattaga aaaccttgaa cccgaacatg agtataagtg tgactcagaa      840

atactctata ataaccacaa gtttactaac gcaagtaaaa ttattaaaac agattttggg      900

agtccaggag agcctcagat tattttttgt agaagtgaag ctgcacatca aggagtaatt      960

acctggaatc cccctcaaag atcatttcat aattttaccc tctgttatat aaaagagaca     1020

gaaaaagatt gcctcaatct ggataaaaac ctgatcaaat atgatttgca aaatttaaaa     1080

ccttatacga aatatgtttt atcattacat gcctacatca ttgcaaaagt gcaacgtaat     1140

ggaagtgctg caatgtgtca tttcacaact aaaagtgctc ctccaagcca ggtctggaac     1200

atgactgtct ccatgacatc agataatagt atgcatgtca agtgtaggcc tcccagggac     1260

cgtaatggcc cccatgaacg ttaccatttg gaagttgaag ctggaaatac tctggttaga     1320

aatgagtcgc ataagaattg cgatttccgt gtaaaagatc ttcaatattc aacagactac     1380

acttttaagg cctattttca caatggagac tatcctggag aaccctttat tttacatcat     1440

tcaacatctt ataattctaa ggcactgata gcatttctgg catttctgat tattgtgaca     1500

tcaatagccc tgcttgttgt tctctacaaa atctatgatc tacataagaa aagatcctgc     1560

aatttagatg aacagcagga gcttgttgaa agggatgatg aaaaacaact gatgaatgtg     1620

gagccaatcc atgcagatat tttgttggaa acttataaga ggaagattgc tgatgaagga     1680

agactttttc tggctgaatt tcagagcatc ccgcgggtgt tcagcaagtt tcctataaag     1740

gaagctcgaa agccctttaa ccagaataaa aaccgttatg ttgacattct tccttatgat     1800

tataaccgtg ttgaactctc tgagataaac ggagatgcag ggtcaaacta cataaatgcc     1860

agctatattg atggtttcaa agaacccagg aaatacattg ctgcacaagg tcccagggat     1920

gaaactgttg atgatttctg gaggatgatt tgggaacaga aagccacagt tattgtcatg     1980

gtcactcgat gtgaagaagg aaacaggaac aagtgtgcag aatactggcc gtcaatggaa     2040

gagggcactc gggcttttgg agatgttgtt gtaaagatca accagcacaa aagatgtcca     2100

gattacatca ttcagaaatt gaacattgta aataaaaaag aaaaagcaac tggaagagag     2160

gtgactcaca ttcagttcac cagctggcca gaccacgggg tgcctgagga tcctcacttg     2220

ctcctcaaac tgagaaggag agtgaatgcc ttcagcaatt tcttcagtgg tcccattgtg     2280

gtgcactgca gtgctggtgt tgggcgcaca ggaacctata tcggaattga tgccatgcta     2340

gaaggcctgg aagccgagaa caaagtggat gtttatggtt atgttgtcaa gctaaggcga     2400

cagagatgcc tgatggttca agtagaggcc cagtacatct tgatccatca ggctttggtg     2460

gaatacaatc agtttggaga aacagaagtg aatttgtctg aattacatcc atatctacat     2520

aacatgaaga aaagggatcc acccagtgag ccgtctccac tagaggctga attccagaga     2580

cttccttcat ataggagctg gaggacacag cacattggaa atcaagaaga aaataaaagt     2640

aaaaacagga attctaatgt catcccatat gactataaca gagtgccact taaacatgag     2700

ctggaaatga gtaaagagag tgagcatgat tcagatgaat cctctgatga tgacagtgat     2760

tcagaggaac caagcaaata catcaatgca tcttttataa tgagctactg gaaacctgaa     2820

gtgatgattg ctgctcaggg accactgaag gagaccattg gtgacttttg gcagatgatc     2880

ttccaaagaa aagtcaaagt tattgttatg ctgacagaac tgaaacatgg agaccaggaa     2940

atctgtgctc agtactgggg agaaggaaag caaacatatg gagatattga agttgacctg     3000

aaagacacag acaaatcttc aacttatacc cttcgtgtct ttgaactgag acattccaag     3060

aggaaagact ctcgaactgt gtaccagtac caatatacaa actggagtgt ggagcagctt     3120

cctgcagaac ccaaggaatt aatctctatg attcaggtcg tcaaacaaaa acttccccag     3180

aagaattcct ctgaagggaa caagcatcac aagagtacac ctctactcat tcactgcagg     3240

gatggatctc agcaaacggg aatattttgt gctttgttaa atctcttaga aagtgcggaa     3300

acagaagagg tagtggatat ttttcaagtg gtaaaagctc tacgcaaagc taggccaggc     3360

atggtttcca cattcgagca atatcaattc ctatatgacg tcattgccag cacctaccct     3420

gctcagaatg gacaagtaaa gaaaaacaac catcaagaag ataaaattga atttgataat     3480

gaagtggaca aagtaaagca ggatgctaat tgtgttaatc cacttggtgc cccagaaaag     3540

ctccctgaag caaaggaaca ggctgaaggt tctgaaccca cgagtggcac tgaggggcca     3600

gaacattctg tcaatggtcc tgcaagtcca gctttaaatc aaggttcata ggaaaagaca     3660

taaatgagga aactccaaac ctcctgttag ctgttatttc tatttttgta gaagtaggaa     3720

gtgaaaatag gtatacagtg gattaattaa atgcagcgaa ccaatatttg tagaagggtt     3780

atattttact actgtggaaa aatatttaag atagttttgc cagaacagtt tgtacagacg     3840

tatgcttatt ttaaaatttt atctcttatt cagtaaaaaa caacttcttt gtaatcgtta     3900

tgtgtgtata tgtatgtgtg tatgggtgtg tgtttgtgtg agagacagag aaagagagag     3960

aattctttca agtgaatcta aaagcttttg cttttccttt gtttttatga agaaaaaata     4020

cattttatat tagaagtgtt aacttagctt gaaggatctg tttttaaaaa tcataaactg     4080

tgtgcagact caataaaatc atgtacattt ctgaaatgac ctcaagatgt cctccttgtt     4140

ctactcatat atatctatct tatatagttt actattttac ttctagagat agtacataaa     4200

ggtggtatgt gtgtgtatgc tactacaaaa aagttgttaa ctaaattaac attgggaaat     4260

cttatattcc atatattagc atttagtcca atgtcttttt aagcttattt aattaaaaaa     4320

tttccagtga gcttatcatg ctgtctttac atggggtttt caattttgca tgctcgatta     4380

ttccctgtac aatatttaaa atttattgct tgatactttt gacaacaaat taggttttgt     4440

acaattgaac ttaaataaat gtcattaaaa taaataaatg caatatgtat taatattcat     4500

tgtataaaaa tagaagaata caaacatatt tgttaaatat ttacatatga aatttaatat     4560

agctattttt atggaatttt tcattgatat gaaaaatatg atattgcata tgcatagttc     4620

ccatgttaaa tcccattcat aactttcatt aaagcattta ctttgaattt ctccaatgct     4680

tagaatgttt ttaccaggaa tggatgtcgc taatcataat aaaattcaac cattattttt     4740

ttcttgttta taatacattg tgttatatgt tcaaatatga aatgtgtatg cacctattga     4800

aatatgttta atgcatttat taacatttgc aggacacttt tacaggcccc aattatccaa     4860

tagtctaata attgtttaag atctagaaaa aaaaaatcaa gaatagtggt atttttcatg     4920

aagtaataaa aactcgtttt ggtgaa                                          4946


<210>  137
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             


Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 


Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         


Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             


Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 


Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 


Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     


Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         


Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             


Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 


Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 


Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     


Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         


Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             


Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 


Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 


Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     


Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         


Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             


Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 


Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 


Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     


Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         


Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             


Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 


Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 


Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     


Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         


Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             


Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 


Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 


Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     


Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         


Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             


Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 


Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 


Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     


Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         


Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 


Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 


Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     


Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         


Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             


Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 


Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 


His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     


Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         


Met Ser Lys Glu Ser Glu His Asp  Ser Asp Glu Ser Ser  Asp Asp Asp 
        995                 1000                 1005             


Ser Asp  Ser Glu Glu Pro Ser  Lys Tyr Ile Asn Ala  Ser Phe Ile 
    1010                 1015                 1020             


Met Ser  Tyr Trp Lys Pro Glu  Val Met Ile Ala Ala  Gln Gly Pro 
    1025                 1030                 1035             


Leu Lys  Glu Thr Ile Gly Asp  Phe Trp Gln Met Ile  Phe Gln Arg 
    1040                 1045                 1050             


Lys Val  Lys Val Ile Val Met  Leu Thr Glu Leu Lys  His Gly Asp 
    1055                 1060                 1065             


Gln Glu  Ile Cys Ala Gln Tyr  Trp Gly Glu Gly Lys  Gln Thr Tyr 
    1070                 1075                 1080             


Gly Asp  Ile Glu Val Asp Leu  Lys Asp Thr Asp Lys  Ser Ser Thr 
    1085                 1090                 1095             


Tyr Thr  Leu Arg Val Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp 
    1100                 1105                 1110             


Ser Arg  Thr Val Tyr Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu 
    1115                 1120                 1125             


Gln Leu  Pro Ala Glu Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val 
    1130                 1135                 1140             


Val Lys  Gln Lys Leu Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys 
    1145                 1150                 1155             


His His  Lys Ser Thr Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser 
    1160                 1165                 1170             


Gln Gln  Thr Gly Ile Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser 
    1175                 1180                 1185             


Ala Glu  Thr Glu Glu Val Val  Asp Ile Phe Gln Val  Val Lys Ala 
    1190                 1195                 1200             


Leu Arg  Lys Ala Arg Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr 
    1205                 1210                 1215             


Gln Phe  Leu Tyr Asp Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn 
    1220                 1225                 1230             


Gly Gln  Val Lys Lys Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe 
    1235                 1240                 1245             


Asp Asn  Glu Val Asp Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn 
    1250                 1255                 1260             


Pro Leu  Gly Ala Pro Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala 
    1265                 1270                 1275             


Glu Gly  Ser Glu Pro Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser 
    1280                 1285                 1290             


Val Asn  Gly Pro Ala Ser Pro  Ala Leu Asn Gln Gly  Ser 
    1295                 1300                 1305     


<210>  138
<211>  1145
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
        35                  40                  45              


Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
    50                  55                  60                  


Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
65                  70                  75                  80  


Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
                85                  90                  95      


Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
            100                 105                 110         


Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
        115                 120                 125             


Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
    130                 135                 140                 


Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
145                 150                 155                 160 


Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
                165                 170                 175     


Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
            180                 185                 190         


Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
        195                 200                 205             


Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
    210                 215                 220                 


Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
225                 230                 235                 240 


Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
                245                 250                 255     


Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
            260                 265                 270         


Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
        275                 280                 285             


Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
    290                 295                 300                 


Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
305                 310                 315                 320 


Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
                325                 330                 335     


Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
            340                 345                 350         


Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
        355                 360                 365             


Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
    370                 375                 380                 


Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
385                 390                 395                 400 


Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
                405                 410                 415     


Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
            420                 425                 430         


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
        435                 440                 445             


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
    450                 455                 460                 


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
465                 470                 475                 480 


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
                485                 490                 495     


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
            500                 505                 510         


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
        515                 520                 525             


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
    530                 535                 540                 


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
545                 550                 555                 560 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
                565                 570                 575     


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
            580                 585                 590         


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
        595                 600                 605             


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
    610                 615                 620                 


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
625                 630                 635                 640 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
                645                 650                 655     


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
            660                 665                 670         


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
        675                 680                 685             


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
    690                 695                 700                 


Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
705                 710                 715                 720 


Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
                725                 730                 735     


Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
            740                 745                 750         


Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
        755                 760                 765             


His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
    770                 775                 780                 


Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
785                 790                 795                 800 


Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
                805                 810                 815     


Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
            820                 825                 830         


Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
        835                 840                 845             


Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
    850                 855                 860                 


Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
865                 870                 875                 880 


Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
                885                 890                 895     


Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
            900                 905                 910         


Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
        915                 920                 925             


Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
    930                 935                 940                 


Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
945                 950                 955                 960 


Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
                965                 970                 975     


Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
            980                 985                 990         


Ser Glu Gly Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 
        995                 1000                 1005             


Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 
    1010                 1015                 1020             


Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 
    1025                 1030                 1035             


Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 
    1040                 1045                 1050             


Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val Ile Ala  Ser Thr Tyr 
    1055                 1060                 1065             


Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 
    1070                 1075                 1080             


Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 
    1085                 1090                 1095             


Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu Lys Leu  Pro Glu Ala 
    1100                 1105                 1110             


Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 
    1115                 1120                 1125             


Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 
    1130                 1135                 1140             


Gly Ser  
    1145 


<210>  139
<211>  6663
<212>  DNA
<213>  Homo sapiens

<400>  139
actgaccccg ctgtaccacg gccctcttgc ggacagcccc ggggacgtcg ttgggacatc       60

gctgggaccc cgggctctgc agccacaacc atgtttggcc ggaagcgcag tgtctccttt      120

gggggcttcg gatggatcga caagaccatg ctggcaagtc tgaaggtcaa gaagcaggag      180

ctggccaaca gctcggatgc gaccctccca gaccggccgc tctcccctcc tctcacggca      240

cctcccacca tgaagtcgtc ggagttcttt gagatgctgg agaaaatgca ggggatcaag      300

cttgaagagc agaagccggg accccagaag aacaaggacg actatatccc ataccccagc      360

atcgacgagg ttgtggagaa gggaggcccg taccctcagg tcatcctgcc acagtttggg      420

ggctattgga tcgaggaccc ggagaacgtg ggcaccccaa catcgctggg gagcagcatc      480

tgtgaggagg aggaagagga caacctcagc cccaacacat ttggctacaa gctcgagtgc      540

aagggtgaag ccagggccta ccggaggcac ttcctgggga aggatcatct aaacttttac      600

tgtaccggca gcagcctggg gaacttgatc ctgtccgtca agtgcgagga agcagagggg      660

atcgagtacc tccgggtcat ccttaggtcc aaactgaaga cggtacatga gcggatcccc      720

ttggctggac tgagcaagct tcccagtgtc cctcagattg caaaggcttt ctgtgatgat      780

gcagtgggac tgagattcaa tcctgtcctg taccccaagg cctcccaaat gattgtgtcc      840

tatgatgagc atgaagtcaa caacacattc aaattcggag tcatttatca aaaagccagg      900

cagaccctgg aggaggagct atttgggaac aatgaggaga gcccagcttt taaggagttc      960

ttggacctgc tgggggacac gatcacactg caggatttca aaggtttccg aggaggcctg     1020

gacgtgaccc acggacagac aggggtggaa tcagtgtaca caacattccg ggacagggag     1080

atcatgtttc acgtttccac aaagctgcca tttaccgacg gagacgccca gcagctccag     1140

agaaagagac acattggaaa tgacatcgtg gccatcatct tccaagagga aaacacgccg     1200

tttgtcccag acatgatagc ctccaatttc ttacatgcct acatcgtcgt gcaggtcgag     1260

accccaggca cagagacccc atcctacaag gtctctgtca ctgcgcggga agatgtgccc     1320

acctttggtc cacctctgcc cagtcccccc gttttccaga agggcccgga attcagggag     1380

tttctgctca ccaagctcac caatgccgag aacgcctgct gcaagtcgga caagtttgca     1440

aagctggagg accggaccag ggctgccctc ctggacaacc ttcacgatga gctccacgcc     1500

cacacacagg ccatgctggg actgggccca gaggaggaca agtttgagaa tggaggccac     1560

ggggggttcc tggagtcttt taagagggcc atccgcgtac gcagccactc catggagacc     1620

atggtgggcg gccagaagaa gtcgcacagt gggggcatcc ctggcagcct cagcgggggc     1680

atctcccaca acagcatgga ggtcaccaag accaccttct cgcctccagt ggtggcggca     1740

acggtgaaga accagtcacg gagtcccatc aagcgacgct cggggctctt cccccgcctg     1800

cacacgggct cagaaggcca gggcgacagc cgggcacgat gtgacagcac atccagcaca     1860

cccaagaccc cagatggtgg acactcctct caggagataa agtctgagac ctcatccaat     1920

cccagctctc cggaaatctg ccccaacaag gagaagccct tcatgaagtt gaaggaaaac     1980

ggccgtgcca tctcccgctc ctcctccagc accagcagcg tcagcagcac tgcaggggag     2040

ggcgaggcca tggaggaggg cgacagtggg ggcagccagc cgtccacgac ctcacccttc     2100

aagcaggagg tgtttgtcta cagcccgtcc ccgagcagcg agagccccag cctgggggca     2160

gctgccaccc cgatcatcat gagccggagt cccacagatg ccaaaagcag aaactccccg     2220

agatcgaacc tgaaattccg ctttgacaag ctcagccatg ccagctctgg tgcgggtcac     2280

taatgtgaaa gtggagtcct tcgcctgtcc aagggaatcc cctcttctgt cctggaaaag     2340

gctcctgtac cagcagtttg ggagtgccgt ccacgaccct gacagtccca gccctgctgc     2400

cccatggcca cgtgcccaca gatgtgctgt tggtccaggt gtcccagtct ggccacagcc     2460

ctgcctccgc cctcacctac atgccctccc agcccctccc atctctggac gaggcctcct     2520

tcctcaggtt cctcctgctc ctgacctccc agtgtgatgt ccgggtcctt tatcatccta     2580

ttcatcctgg agaggaaaag tgtcgggcaa agggggatct ggggggagct cagcagtgac     2640

tggggagctg gtctgcctca gagacagagt agggggtggg agcagagcct cggtgagggt     2700

cttggccaca gggcagtgcc ttcctgaacg tggcaggctt tactaccagg aacgcactcg     2760

gtggtggagg ccccatgttc ccaggagcca agattcgtag catccttgag gccatcctga     2820

taaaattcgg cgctattgcc cccgtagctc tggagctcta aaccgtctat ctgcttctgt     2880

gctgaacgcc tttcccatct gctgacgtag gcccagggct gccctgcccc tgctgccagt     2940

gtaccgtgag cggggctcca gccagttcaa gctcagagcc agagctggac gggccagaac     3000

tgcgctgcac acttcctgga ctgaggcggg gactttgggt cccacccggt ttctcctgat     3060

tatggctgct gtggggtgag gggagggagg ggcagccccg aggcagtctc ttccctttga     3120

gaagatattt tcccacaaag gggtgggaag ccaggagtga gaaggaattc agggagagca     3180

aaggagccag tgctgagatg ctgctgtgtt ggttgaggaa aacctcgggc ctgagggcca     3240

ggccggagcc caggtctctg ctgacaatgg gggttcaagg aagacgtcgt tatctcccct     3300

ccccacttac tcgaggagag aggtgagggg gggatgactt gcgggttctg atcaggcccc     3360

tgggtgggga aggggcacag tgtccctcag cagcttacgc ccctggagtc ttggggggcc     3420

cagcctggcc ctggggcctt ttccagctac tgtgcccttg ggcagctgcg tctggggctc     3480

aaccccccaa tcctgttccc ctctccagct gcgggtctgt aggcagctgt cacatctgaa     3540

gggtttctgc aacctggacc ccatctgggt gtgggtcaga ccctgtgacc cacatgccac     3600

ccccaccctc cacagagccc ccttgctggg acagccagct cacctccaag gacatcccct     3660

cctggcttct cccccttccg agtctgcagc gccgtgggct tctctgccga tgggcccggg     3720

ttggggttaa ggtgggcatc ctccaggtac aacgagcctg aagagcccct ttcagtgcag     3780

acggggctgc agagtgacac tggctgggca cctgccccac gaccaatgac aaggatttcc     3840

agctgaatgc tttattccca tagggatctg gacctgtgcc caagatataa atactacact     3900

tttttttttt ttttttaact gacattgtga aattctccct atagcttttg ccattcaagc     3960

aacattgtga tctttcttcc ccgccacgtg tgtgggaatg attgagtcct gtttgcaagc     4020

tggagaggag ctctcccttt gctagtactt tctctaaagt actagtctag taaaatttat     4080

tcttgttaga aggtcaacaa aatatctgtt tagcttttat gaagagtcac cgtagcagcc     4140

cccacggctg gaaagaggcc tgtacgttct ggacgcgttt tgttggctgg gcttctggag     4200

gcactggcaa ggtcaaactg catttcttta agaacagttg caggatctgg ctcgcctctg     4260

tgggaagccg gcattacagg tgcttggtgg atgggccgtg tcacattgcc atctggggtc     4320

ctttggggtt tccaggttgt caccatgctg tcccatttgg gaatcccata cctgcctgtc     4380

cccactgcgc tggctgaccc ttgctgcctg ctgcctcttg ggagggcttt gtccctgcct     4440

ctgagctggt gggcaggatg gctgggtggc ccccagagaa gcacagacct gagatggggt     4500

ctccatgccc ggtttgctgt tggaatgatc tgaacaggac cccaaatgcc tcttccctct     4560

ggtcatgcct cactatctct aggagctcca tcctgtggct tccagagtgt gcacttccag     4620

cccacccggg cagtgctgag agggaggagg agaacaagga tggcccagcc tcccctccct     4680

cccctagacc acggggcggg cagctcgggt tcctggaggg ctgtttcccc cacgctgtcc     4740

ctacatctgc tctgatctaa aatgtctttc cttttatgct gcgcccagtc ttggggctca     4800

aagatttgcc caaacctcat tggccctcgt gactaggctc atctagatgg tgctcacgct     4860

ggtgtttgag gcatttccac tgtgatctcc acgaggggat gttttccggg acacatctct     4920

ggctctggga actgcctgac tcactgaaga aactactttt caggcactgt agggtcaccc     4980

atatgcctcc agctcagttg acgcttaaaa acaggtgcag aaaagctcgc gatggaaggt     5040

cttaatgaga gtgtctgtct atgccaatca tgtaaaatga cgtttcttga aaaagattca     5100

gtggttcagc tttgtcagca tcatctcaac acaagcctgc tggctctttt tagcatctca     5160

tccaaccatg tcatcgtcca gatgagaaat cttagcccag gtgaggggag taacttgctt     5220

gaggtcacac agctggctgt tggcaaagct gggattagaa ccctcaaccc agggtccctt     5280

cctctgcagc gcctacatgg ttggttgaat aagtggctgc gtttcctggg gccctgggtt     5340

ttggggaagc cagttagctg ctgctttggc actggcatgg aggtgagcag tcaaggatgc     5400

tggtgaggct gcagtttctg ctctttttca tcagggggga tagtctctag gatttttcag     5460

tgaggaccct tgggctttgg atgcagcttg aaccaagaaa acgaggaggg aaagggattc     5520

agtgaactat tcctcagtgg gatcggttct tcagctcctg atgggggctg tgtaatgggg     5580

gcagaggcca gggaaaaaga tgctgttcac ccaccctcag cttccctttt cctaaattaa     5640

gaggaaaagt ggtcaaagaa aaactcttca tttctccctg attcttaaac gaaggtggtt     5700

aatagaaact caggctcccg tgacaaggca ggacaagagc ctgtttcgct ttcctccctg     5760

accctgccag gtgccaactc aaacactacc tttctcattg gtttctaagt cagtagagac     5820

agatctgttt taagcagttg ggggttcgag tagatctcat gggtacagga ggccagcagg     5880

gaccaggcca gtcagccatg ctcaggaccc ctcggctcct cccccagcct ctagctaccc     5940

tgtatcgagg caaggggagg ccagtaaagt ttgccaagcc tgatcctgca gcctggtggg     6000

gctggctggg gtattctttt accaaactct gttttaccgc cagccccttg tacaccccaa     6060

tcccatgtct ccctcccttc agctggaccg tgtgcccctt tgggaggaag aagacaagcc     6120

ccactagggc caagggcagc agagccctgc cgagtgagag gctgtggggc agcggctctg     6180

tcctgtgcct taccagccct ggggaggggg gcatttggct ggaagactgg aatttaattg     6240

ccatcgtctt tgattttgtg acatttctgc ttggaagtgt gaactacccc cccccccccg     6300

cttcctgctc cttagcatgc gtgcagctct ctcctgtttt gggtgttccc cttggacact     6360

ccagctcggg gactgctggc gtgtgaatgt gcagattccc ctgtgtggtc gaacctaaga     6420

actgtggctt ggaagtgatg ctccatgtga cgacgacttt gctttctttc ctcttagtga     6480

ggaggtgatt cgtagatccc aactgcctat gtaatgtaaa taatgtacat ttaatttatt     6540

gctatggtag cacattgtat ttgttaatgt acaaaacaaa ttctaaaagg ttgacaaatg     6600

tatattttgt tgcttaaatg tgtctttgca gaaattgaca ataaataaca tattttgtgt     6660

cca                                                                   6663


<210>  140
<211>  6618
<212>  DNA
<213>  Homo sapiens

<400>  140
actgaccccg ctgtaccacg gccctcttgc ggacagcccc ggggacgtcg ttgggacatc       60

gctgggaccc cgggctctgc agccacaacc atgtttggcc ggaagcgcag tgtctccttt      120

gggggcttcg gatggatcga caagaccatg ctggcaagtc tgaaggtcaa gaagcaggag      180

ctggccaaca gctcggatgc gaccctccca gaccggccgc tctcccctcc tctcacggca      240

cctcccacca tgaagtcgtc ggagttcttt gagatgctgg agaaaatgca ggacgactat      300

atcccatacc ccagcatcga cgaggttgtg gagaagggag gcccgtaccc tcaggtcatc      360

ctgccacagt ttgggggcta ttggatcgag gacccggaga acgtgggcac cccaacatcg      420

ctggggagca gcatctgtga ggaggaggaa gaggacaacc tcagccccaa cacatttggc      480

tacaagctcg agtgcaaggg tgaagccagg gcctaccgga ggcacttcct ggggaaggat      540

catctaaact tttactgtac cggcagcagc ctggggaact tgatcctgtc cgtcaagtgc      600

gaggaagcag aggggatcga gtacctccgg gtcatcctta ggtccaaact gaagacggta      660

catgagcgga tccccttggc tggactgagc aagcttccca gtgtccctca gattgcaaag      720

gctttctgtg atgatgcagt gggactgaga ttcaatcctg tcctgtaccc caaggcctcc      780

caaatgattg tgtcctatga tgagcatgaa gtcaacaaca cattcaaatt cggagtcatt      840

tatcaaaaag ccaggcagac cctggaggag gagctatttg ggaacaatga ggagagccca      900

gcttttaagg agttcttgga cctgctgggg gacacgatca cactgcagga tttcaaaggt      960

ttccgaggag gcctggacgt gacccacgga cagacagggg tggaatcagt gtacacaaca     1020

ttccgggaca gggagatcat gtttcacgtt tccacaaagc tgccatttac cgacggagac     1080

gcccagcagc tccagagaaa gagacacatt ggaaatgaca tcgtggccat catcttccaa     1140

gaggaaaaca cgccgtttgt cccagacatg atagcctcca atttcttaca tgcctacatc     1200

gtcgtgcagg tcgagacccc aggcacagag accccatcct acaaggtctc tgtcactgcg     1260

cgggaagatg tgcccacctt tggtccacct ctgcccagtc cccccgtttt ccagaagggc     1320

ccggaattca gggagtttct gctcaccaag ctcaccaatg ccgagaacgc ctgctgcaag     1380

tcggacaagt ttgcaaagct ggaggaccgg accagggctg ccctcctgga caaccttcac     1440

gatgagctcc acgcccacac acaggccatg ctgggactgg gcccagagga ggacaagttt     1500

gagaatggag gccacggggg gttcctggag tcttttaaga gggccatccg cgtacgcagc     1560

cactccatgg agaccatggt gggcggccag aagaagtcgc acagtggggg catccctggc     1620

agcctcagcg ggggcatctc ccacaacagc atggaggtca ccaagaccac cttctcgcct     1680

ccagtggtgg cggcaacggt gaagaaccag tcacggagtc ccatcaagcg acgctcgggg     1740

ctcttccccc gcctgcacac gggctcagaa ggccagggcg acagccgggc acgatgtgac     1800

agcacatcca gcacacccaa gaccccagat ggtggacact cctctcagga gataaagtct     1860

gagacctcat ccaatcccag ctctccggaa atctgcccca acaaggagaa gcccttcatg     1920

aagttgaagg aaaacggccg tgccatctcc cgctcctcct ccagcaccag cagcgtcagc     1980

agcactgcag gggagggcga ggccatggag gagggcgaca gtgggggcag ccagccgtcc     2040

acgacctcac ccttcaagca ggaggtgttt gtctacagcc cgtccccgag cagcgagagc     2100

cccagcctgg gggcagctgc caccccgatc atcatgagcc ggagtcccac agatgccaaa     2160

agcagaaact ccccgagatc gaacctgaaa ttccgctttg acaagctcag ccatgccagc     2220

tctggtgcgg gtcactaatg tgaaagtgga gtccttcgcc tgtccaaggg aatcccctct     2280

tctgtcctgg aaaaggctcc tgtaccagca gtttgggagt gccgtccacg accctgacag     2340

tcccagccct gctgccccat ggccacgtgc ccacagatgt gctgttggtc caggtgtccc     2400

agtctggcca cagccctgcc tccgccctca cctacatgcc ctcccagccc ctcccatctc     2460

tggacgaggc ctccttcctc aggttcctcc tgctcctgac ctcccagtgt gatgtccggg     2520

tcctttatca tcctattcat cctggagagg aaaagtgtcg ggcaaagggg gatctggggg     2580

gagctcagca gtgactgggg agctggtctg cctcagagac agagtagggg gtgggagcag     2640

agcctcggtg agggtcttgg ccacagggca gtgccttcct gaacgtggca ggctttacta     2700

ccaggaacgc actcggtggt ggaggcccca tgttcccagg agccaagatt cgtagcatcc     2760

ttgaggccat cctgataaaa ttcggcgcta ttgcccccgt agctctggag ctctaaaccg     2820

tctatctgct tctgtgctga acgcctttcc catctgctga cgtaggccca gggctgccct     2880

gcccctgctg ccagtgtacc gtgagcgggg ctccagccag ttcaagctca gagccagagc     2940

tggacgggcc agaactgcgc tgcacacttc ctggactgag gcggggactt tgggtcccac     3000

ccggtttctc ctgattatgg ctgctgtggg gtgaggggag ggaggggcag ccccgaggca     3060

gtctcttccc tttgagaaga tattttccca caaaggggtg ggaagccagg agtgagaagg     3120

aattcaggga gagcaaagga gccagtgctg agatgctgct gtgttggttg aggaaaacct     3180

cgggcctgag ggccaggccg gagcccaggt ctctgctgac aatgggggtt caaggaagac     3240

gtcgttatct cccctcccca cttactcgag gagagaggtg agggggggat gacttgcggg     3300

ttctgatcag gcccctgggt ggggaagggg cacagtgtcc ctcagcagct tacgcccctg     3360

gagtcttggg gggcccagcc tggccctggg gccttttcca gctactgtgc ccttgggcag     3420

ctgcgtctgg ggctcaaccc cccaatcctg ttcccctctc cagctgcggg tctgtaggca     3480

gctgtcacat ctgaagggtt tctgcaacct ggaccccatc tgggtgtggg tcagaccctg     3540

tgacccacat gccaccccca ccctccacag agcccccttg ctgggacagc cagctcacct     3600

ccaaggacat cccctcctgg cttctccccc ttccgagtct gcagcgccgt gggcttctct     3660

gccgatgggc ccgggttggg gttaaggtgg gcatcctcca ggtacaacga gcctgaagag     3720

cccctttcag tgcagacggg gctgcagagt gacactggct gggcacctgc cccacgacca     3780

atgacaagga tttccagctg aatgctttat tcccataggg atctggacct gtgcccaaga     3840

tataaatact acactttttt tttttttttt taactgacat tgtgaaattc tccctatagc     3900

ttttgccatt caagcaacat tgtgatcttt cttccccgcc acgtgtgtgg gaatgattga     3960

gtcctgtttg caagctggag aggagctctc cctttgctag tactttctct aaagtactag     4020

tctagtaaaa tttattcttg ttagaaggtc aacaaaatat ctgtttagct tttatgaaga     4080

gtcaccgtag cagcccccac ggctggaaag aggcctgtac gttctggacg cgttttgttg     4140

gctgggcttc tggaggcact ggcaaggtca aactgcattt ctttaagaac agttgcagga     4200

tctggctcgc ctctgtggga agccggcatt acaggtgctt ggtggatggg ccgtgtcaca     4260

ttgccatctg gggtcctttg gggtttccag gttgtcacca tgctgtccca tttgggaatc     4320

ccatacctgc ctgtccccac tgcgctggct gacccttgct gcctgctgcc tcttgggagg     4380

gctttgtccc tgcctctgag ctggtgggca ggatggctgg gtggccccca gagaagcaca     4440

gacctgagat ggggtctcca tgcccggttt gctgttggaa tgatctgaac aggaccccaa     4500

atgcctcttc cctctggtca tgcctcacta tctctaggag ctccatcctg tggcttccag     4560

agtgtgcact tccagcccac ccgggcagtg ctgagaggga ggaggagaac aaggatggcc     4620

cagcctcccc tccctcccct agaccacggg gcgggcagct cgggttcctg gagggctgtt     4680

tcccccacgc tgtccctaca tctgctctga tctaaaatgt ctttcctttt atgctgcgcc     4740

cagtcttggg gctcaaagat ttgcccaaac ctcattggcc ctcgtgacta ggctcatcta     4800

gatggtgctc acgctggtgt ttgaggcatt tccactgtga tctccacgag gggatgtttt     4860

ccgggacaca tctctggctc tgggaactgc ctgactcact gaagaaacta cttttcaggc     4920

actgtagggt cacccatatg cctccagctc agttgacgct taaaaacagg tgcagaaaag     4980

ctcgcgatgg aaggtcttaa tgagagtgtc tgtctatgcc aatcatgtaa aatgacgttt     5040

cttgaaaaag attcagtggt tcagctttgt cagcatcatc tcaacacaag cctgctggct     5100

ctttttagca tctcatccaa ccatgtcatc gtccagatga gaaatcttag cccaggtgag     5160

gggagtaact tgcttgaggt cacacagctg gctgttggca aagctgggat tagaaccctc     5220

aacccagggt cccttcctct gcagcgccta catggttggt tgaataagtg gctgcgtttc     5280

ctggggccct gggttttggg gaagccagtt agctgctgct ttggcactgg catggaggtg     5340

agcagtcaag gatgctggtg aggctgcagt ttctgctctt tttcatcagg ggggatagtc     5400

tctaggattt ttcagtgagg acccttgggc tttggatgca gcttgaacca agaaaacgag     5460

gagggaaagg gattcagtga actattcctc agtgggatcg gttcttcagc tcctgatggg     5520

ggctgtgtaa tgggggcaga ggccagggaa aaagatgctg ttcacccacc ctcagcttcc     5580

cttttcctaa attaagagga aaagtggtca aagaaaaact cttcatttct ccctgattct     5640

taaacgaagg tggttaatag aaactcaggc tcccgtgaca aggcaggaca agagcctgtt     5700

tcgctttcct ccctgaccct gccaggtgcc aactcaaaca ctacctttct cattggtttc     5760

taagtcagta gagacagatc tgttttaagc agttgggggt tcgagtagat ctcatgggta     5820

caggaggcca gcagggacca ggccagtcag ccatgctcag gacccctcgg ctcctccccc     5880

agcctctagc taccctgtat cgaggcaagg ggaggccagt aaagtttgcc aagcctgatc     5940

ctgcagcctg gtggggctgg ctggggtatt cttttaccaa actctgtttt accgccagcc     6000

ccttgtacac cccaatccca tgtctccctc ccttcagctg gaccgtgtgc ccctttggga     6060

ggaagaagac aagccccact agggccaagg gcagcagagc cctgccgagt gagaggctgt     6120

ggggcagcgg ctctgtcctg tgccttacca gccctgggga ggggggcatt tggctggaag     6180

actggaattt aattgccatc gtctttgatt ttgtgacatt tctgcttgga agtgtgaact     6240

accccccccc ccccgcttcc tgctccttag catgcgtgca gctctctcct gttttgggtg     6300

ttccccttgg acactccagc tcggggactg ctggcgtgtg aatgtgcaga ttcccctgtg     6360

tggtcgaacc taagaactgt ggcttggaag tgatgctcca tgtgacgacg actttgcttt     6420

ctttcctctt agtgaggagg tgattcgtag atcccaactg cctatgtaat gtaaataatg     6480

tacatttaat ttattgctat ggtagcacat tgtatttgtt aatgtacaaa acaaattcta     6540

aaaggttgac aaatgtatat tttgttgctt aaatgtgtct ttgcagaaat tgacaataaa     6600

taacatattt tgtgtcca                                                   6618


<210>  141
<211>  6719
<212>  DNA
<213>  Homo sapiens

<400>  141
gtgcgctggg gccggccggg gtgcgcgcgt gcgcggcagg actgctgcga gggaccccgc       60

cgccccggag gaggaggagg aggaggagga ggaggaggag ggggctgggc cgagggaggg      120

ggcgaccgcg gggactgagg tgcccttcgc tccgggtcca gaggcagccg cgcgccaggc      180

ggcgcagaag gatcgacaag accatgctgg caagtctgaa ggtcaagaag caggagctgg      240

ccaacagctc ggatgcgacc ctcccagacc ggccgctctc ccctcctctc acggcacctc      300

ccaccatgaa gtcgtcggag ttctttgaga tgctggagaa aatgcagggg atcaagcttg      360

aagagcagaa gccgggaccc cagaagaaca aggacgacta tatcccatac cccagcatcg      420

acgaggttgt ggagaaggga ggcccgtacc ctcaggtcat cctgccacag tttgggggct      480

attggatcga ggacccggag aacgtgggca ccccaacatc gctggggagc agcatctgtg      540

aggaggagga agaggacaac ctcagcccca acacatttgg ctacaagctc gagtgcaagg      600

gtgaagccag ggcctaccgg aggcacttcc tggggaagga tcatctaaac ttttactgta      660

ccggcagcag cctggggaac ttgatcctgt ccgtcaagtg cgaggaagca gaggggatcg      720

agtacctccg ggtcatcctt aggtccaaac tgaagacggt acatgagcgg atccccttgg      780

ctggactgag caagcttccc agtgtccctc agattgcaaa ggctttctgt gatgatgcag      840

tgggactgag attcaatcct gtcctgtacc ccaaggcctc ccaaatgatt gtgtcctatg      900

atgagcatga agtcaacaac acattcaaat tcggagtcat ttatcaaaaa gccaggcaga      960

ccctggagga ggagctattt gggaacaatg aggagagccc agcttttaag gagttcttgg     1020

acctgctggg ggacacgatc acactgcagg atttcaaagg tttccgagga ggcctggacg     1080

tgacccacgg acagacaggg gtggaatcag tgtacacaac attccgggac agggagatca     1140

tgtttcacgt ttccacaaag ctgccattta ccgacggaga cgcccagcag ctccagagaa     1200

agagacacat tggaaatgac atcgtggcca tcatcttcca agaggaaaac acgccgtttg     1260

tcccagacat gatagcctcc aatttcttac atgcctacat cgtcgtgcag gtcgagaccc     1320

caggcacaga gaccccatcc tacaaggtct ctgtcactgc gcgggaagat gtgcccacct     1380

ttggtccacc tctgcccagt ccccccgttt tccagaaggg cccggaattc agggagtttc     1440

tgctcaccaa gctcaccaat gccgagaacg cctgctgcaa gtcggacaag tttgcaaagc     1500

tggaggaccg gaccagggct gccctcctgg acaaccttca cgatgagctc cacgcccaca     1560

cacaggccat gctgggactg ggcccagagg aggacaagtt tgagaatgga ggccacgggg     1620

ggttcctgga gtcttttaag agggccatcc gcgtacgcag ccactccatg gagaccatgg     1680

tgggcggcca gaagaagtcg cacagtgggg gcatccctgg cagcctcagc gggggcatct     1740

cccacaacag catggaggtc accaagacca ccttctcgcc tccagtggtg gcggcaacgg     1800

tgaagaacca gtcacggagt cccatcaagc gacgctcggg gctcttcccc cgcctgcaca     1860

cgggctcaga aggccagggc gacagccggg cacgatgtga cagcacatcc agcacaccca     1920

agaccccaga tggtggacac tcctctcagg agataaagtc tgagacctca tccaatccca     1980

gctctccgga aatctgcccc aacaaggaga agcccttcat gaagttgaag gaaaacggcc     2040

gtgccatctc ccgctcctcc tccagcacca gcagcgtcag cagcactgca ggggagggcg     2100

aggccatgga ggagggcgac agtgggggca gccagccgtc cacgacctca cccttcaagc     2160

aggaggtgtt tgtctacagc ccgtccccga gcagcgagag ccccagcctg ggggcagctg     2220

ccaccccgat catcatgagc cggagtccca cagatgccaa aagcagaaac tccccgagat     2280

cgaacctgaa attccgcttt gacaagctca gccatgccag ctctggtgcg ggtcactaat     2340

gtgaaagtgg agtccttcgc ctgtccaagg gaatcccctc ttctgtcctg gaaaaggctc     2400

ctgtaccagc agtttgggag tgccgtccac gaccctgaca gtcccagccc tgctgcccca     2460

tggccacgtg cccacagatg tgctgttggt ccaggtgtcc cagtctggcc acagccctgc     2520

ctccgccctc acctacatgc cctcccagcc cctcccatct ctggacgagg cctccttcct     2580

caggttcctc ctgctcctga cctcccagtg tgatgtccgg gtcctttatc atcctattca     2640

tcctggagag gaaaagtgtc gggcaaaggg ggatctgggg ggagctcagc agtgactggg     2700

gagctggtct gcctcagaga cagagtaggg ggtgggagca gagcctcggt gagggtcttg     2760

gccacagggc agtgccttcc tgaacgtggc aggctttact accaggaacg cactcggtgg     2820

tggaggcccc atgttcccag gagccaagat tcgtagcatc cttgaggcca tcctgataaa     2880

attcggcgct attgcccccg tagctctgga gctctaaacc gtctatctgc ttctgtgctg     2940

aacgcctttc ccatctgctg acgtaggccc agggctgccc tgcccctgct gccagtgtac     3000

cgtgagcggg gctccagcca gttcaagctc agagccagag ctggacgggc cagaactgcg     3060

ctgcacactt cctggactga ggcggggact ttgggtccca cccggtttct cctgattatg     3120

gctgctgtgg ggtgagggga gggaggggca gccccgaggc agtctcttcc ctttgagaag     3180

atattttccc acaaaggggt gggaagccag gagtgagaag gaattcaggg agagcaaagg     3240

agccagtgct gagatgctgc tgtgttggtt gaggaaaacc tcgggcctga gggccaggcc     3300

ggagcccagg tctctgctga caatgggggt tcaaggaaga cgtcgttatc tcccctcccc     3360

acttactcga ggagagaggt gaggggggga tgacttgcgg gttctgatca ggcccctggg     3420

tggggaaggg gcacagtgtc cctcagcagc ttacgcccct ggagtcttgg ggggcccagc     3480

ctggccctgg ggccttttcc agctactgtg cccttgggca gctgcgtctg gggctcaacc     3540

ccccaatcct gttcccctct ccagctgcgg gtctgtaggc agctgtcaca tctgaagggt     3600

ttctgcaacc tggaccccat ctgggtgtgg gtcagaccct gtgacccaca tgccaccccc     3660

accctccaca gagccccctt gctgggacag ccagctcacc tccaaggaca tcccctcctg     3720

gcttctcccc cttccgagtc tgcagcgccg tgggcttctc tgccgatggg cccgggttgg     3780

ggttaaggtg ggcatcctcc aggtacaacg agcctgaaga gcccctttca gtgcagacgg     3840

ggctgcagag tgacactggc tgggcacctg ccccacgacc aatgacaagg atttccagct     3900

gaatgcttta ttcccatagg gatctggacc tgtgcccaag atataaatac tacacttttt     3960

tttttttttt ttaactgaca ttgtgaaatt ctccctatag cttttgccat tcaagcaaca     4020

ttgtgatctt tcttccccgc cacgtgtgtg ggaatgattg agtcctgttt gcaagctgga     4080

gaggagctct ccctttgcta gtactttctc taaagtacta gtctagtaaa atttattctt     4140

gttagaaggt caacaaaata tctgtttagc ttttatgaag agtcaccgta gcagccccca     4200

cggctggaaa gaggcctgta cgttctggac gcgttttgtt ggctgggctt ctggaggcac     4260

tggcaaggtc aaactgcatt tctttaagaa cagttgcagg atctggctcg cctctgtggg     4320

aagccggcat tacaggtgct tggtggatgg gccgtgtcac attgccatct ggggtccttt     4380

ggggtttcca ggttgtcacc atgctgtccc atttgggaat cccatacctg cctgtcccca     4440

ctgcgctggc tgacccttgc tgcctgctgc ctcttgggag ggctttgtcc ctgcctctga     4500

gctggtgggc aggatggctg ggtggccccc agagaagcac agacctgaga tggggtctcc     4560

atgcccggtt tgctgttgga atgatctgaa caggacccca aatgcctctt ccctctggtc     4620

atgcctcact atctctagga gctccatcct gtggcttcca gagtgtgcac ttccagccca     4680

cccgggcagt gctgagaggg aggaggagaa caaggatggc ccagcctccc ctccctcccc     4740

tagaccacgg ggcgggcagc tcgggttcct ggagggctgt ttcccccacg ctgtccctac     4800

atctgctctg atctaaaatg tctttccttt tatgctgcgc ccagtcttgg ggctcaaaga     4860

tttgcccaaa cctcattggc cctcgtgact aggctcatct agatggtgct cacgctggtg     4920

tttgaggcat ttccactgtg atctccacga ggggatgttt tccgggacac atctctggct     4980

ctgggaactg cctgactcac tgaagaaact acttttcagg cactgtaggg tcacccatat     5040

gcctccagct cagttgacgc ttaaaaacag gtgcagaaaa gctcgcgatg gaaggtctta     5100

atgagagtgt ctgtctatgc caatcatgta aaatgacgtt tcttgaaaaa gattcagtgg     5160

ttcagctttg tcagcatcat ctcaacacaa gcctgctggc tctttttagc atctcatcca     5220

accatgtcat cgtccagatg agaaatctta gcccaggtga ggggagtaac ttgcttgagg     5280

tcacacagct ggctgttggc aaagctggga ttagaaccct caacccaggg tcccttcctc     5340

tgcagcgcct acatggttgg ttgaataagt ggctgcgttt cctggggccc tgggttttgg     5400

ggaagccagt tagctgctgc tttggcactg gcatggaggt gagcagtcaa ggatgctggt     5460

gaggctgcag tttctgctct ttttcatcag gggggatagt ctctaggatt tttcagtgag     5520

gacccttggg ctttggatgc agcttgaacc aagaaaacga ggagggaaag ggattcagtg     5580

aactattcct cagtgggatc ggttcttcag ctcctgatgg gggctgtgta atgggggcag     5640

aggccaggga aaaagatgct gttcacccac cctcagcttc ccttttccta aattaagagg     5700

aaaagtggtc aaagaaaaac tcttcatttc tccctgattc ttaaacgaag gtggttaata     5760

gaaactcagg ctcccgtgac aaggcaggac aagagcctgt ttcgctttcc tccctgaccc     5820

tgccaggtgc caactcaaac actacctttc tcattggttt ctaagtcagt agagacagat     5880

ctgttttaag cagttggggg ttcgagtaga tctcatgggt acaggaggcc agcagggacc     5940

aggccagtca gccatgctca ggacccctcg gctcctcccc cagcctctag ctaccctgta     6000

tcgaggcaag gggaggccag taaagtttgc caagcctgat cctgcagcct ggtggggctg     6060

gctggggtat tcttttacca aactctgttt taccgccagc cccttgtaca ccccaatccc     6120

atgtctccct cccttcagct ggaccgtgtg cccctttggg aggaagaaga caagccccac     6180

tagggccaag ggcagcagag ccctgccgag tgagaggctg tggggcagcg gctctgtcct     6240

gtgccttacc agccctgggg aggggggcat ttggctggaa gactggaatt taattgccat     6300

cgtctttgat tttgtgacat ttctgcttgg aagtgtgaac tacccccccc cccccgcttc     6360

ctgctcctta gcatgcgtgc agctctctcc tgttttgggt gttccccttg gacactccag     6420

ctcggggact gctggcgtgt gaatgtgcag attcccctgt gtggtcgaac ctaagaactg     6480

tggcttggaa gtgatgctcc atgtgacgac gactttgctt tctttcctct tagtgaggag     6540

gtgattcgta gatcccaact gcctatgtaa tgtaaataat gtacatttaa tttattgcta     6600

tggtagcaca ttgtatttgt taatgtacaa aacaaattct aaaaggttga caaatgtata     6660

ttttgttgct taaatgtgtc tttgcagaaa ttgacaataa ataacatatt ttgtgtcca      6719


<210>  142
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Phe Gly Arg Lys Arg Ser Val Ser Phe Gly Gly Phe Gly Trp Ile 
1               5                   10                  15      


Asp Lys Thr Met Leu Ala Ser Leu Lys Val Lys Lys Gln Glu Leu Ala 
            20                  25                  30          


Asn Ser Ser Asp Ala Thr Leu Pro Asp Arg Pro Leu Ser Pro Pro Leu 
        35                  40                  45              


Thr Ala Pro Pro Thr Met Lys Ser Ser Glu Phe Phe Glu Met Leu Glu 
    50                  55                  60                  


Lys Met Gln Gly Ile Lys Leu Glu Glu Gln Lys Pro Gly Pro Gln Lys 
65                  70                  75                  80  


Asn Lys Asp Asp Tyr Ile Pro Tyr Pro Ser Ile Asp Glu Val Val Glu 
                85                  90                  95      


Lys Gly Gly Pro Tyr Pro Gln Val Ile Leu Pro Gln Phe Gly Gly Tyr 
            100                 105                 110         


Trp Ile Glu Asp Pro Glu Asn Val Gly Thr Pro Thr Ser Leu Gly Ser 
        115                 120                 125             


Ser Ile Cys Glu Glu Glu Glu Glu Asp Asn Leu Ser Pro Asn Thr Phe 
    130                 135                 140                 


Gly Tyr Lys Leu Glu Cys Lys Gly Glu Ala Arg Ala Tyr Arg Arg His 
145                 150                 155                 160 


Phe Leu Gly Lys Asp His Leu Asn Phe Tyr Cys Thr Gly Ser Ser Leu 
                165                 170                 175     


Gly Asn Leu Ile Leu Ser Val Lys Cys Glu Glu Ala Glu Gly Ile Glu 
            180                 185                 190         


Tyr Leu Arg Val Ile Leu Arg Ser Lys Leu Lys Thr Val His Glu Arg 
        195                 200                 205             


Ile Pro Leu Ala Gly Leu Ser Lys Leu Pro Ser Val Pro Gln Ile Ala 
    210                 215                 220                 


Lys Ala Phe Cys Asp Asp Ala Val Gly Leu Arg Phe Asn Pro Val Leu 
225                 230                 235                 240 


Tyr Pro Lys Ala Ser Gln Met Ile Val Ser Tyr Asp Glu His Glu Val 
                245                 250                 255     


Asn Asn Thr Phe Lys Phe Gly Val Ile Tyr Gln Lys Ala Arg Gln Thr 
            260                 265                 270         


Leu Glu Glu Glu Leu Phe Gly Asn Asn Glu Glu Ser Pro Ala Phe Lys 
        275                 280                 285             


Glu Phe Leu Asp Leu Leu Gly Asp Thr Ile Thr Leu Gln Asp Phe Lys 
    290                 295                 300                 


Gly Phe Arg Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Val Glu 
305                 310                 315                 320 


Ser Val Tyr Thr Thr Phe Arg Asp Arg Glu Ile Met Phe His Val Ser 
                325                 330                 335     


Thr Lys Leu Pro Phe Thr Asp Gly Asp Ala Gln Gln Leu Gln Arg Lys 
            340                 345                 350         


Arg His Ile Gly Asn Asp Ile Val Ala Ile Ile Phe Gln Glu Glu Asn 
        355                 360                 365             


Thr Pro Phe Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr 
    370                 375                 380                 


Ile Val Val Gln Val Glu Thr Pro Gly Thr Glu Thr Pro Ser Tyr Lys 
385                 390                 395                 400 


Val Ser Val Thr Ala Arg Glu Asp Val Pro Thr Phe Gly Pro Pro Leu 
                405                 410                 415     


Pro Ser Pro Pro Val Phe Gln Lys Gly Pro Glu Phe Arg Glu Phe Leu 
            420                 425                 430         


Leu Thr Lys Leu Thr Asn Ala Glu Asn Ala Cys Cys Lys Ser Asp Lys 
        435                 440                 445             


Phe Ala Lys Leu Glu Asp Arg Thr Arg Ala Ala Leu Leu Asp Asn Leu 
    450                 455                 460                 


His Asp Glu Leu His Ala His Thr Gln Ala Met Leu Gly Leu Gly Pro 
465                 470                 475                 480 


Glu Glu Asp Lys Phe Glu Asn Gly Gly His Gly Gly Phe Leu Glu Ser 
                485                 490                 495     


Phe Lys Arg Ala Ile Arg Val Arg Ser His Ser Met Glu Thr Met Val 
            500                 505                 510         


Gly Gly Gln Lys Lys Ser His Ser Gly Gly Ile Pro Gly Ser Leu Ser 
        515                 520                 525             


Gly Gly Ile Ser His Asn Ser Met Glu Val Thr Lys Thr Thr Phe Ser 
    530                 535                 540                 


Pro Pro Val Val Ala Ala Thr Val Lys Asn Gln Ser Arg Ser Pro Ile 
545                 550                 555                 560 


Lys Arg Arg Ser Gly Leu Phe Pro Arg Leu His Thr Gly Ser Glu Gly 
                565                 570                 575     


Gln Gly Asp Ser Arg Ala Arg Cys Asp Ser Thr Ser Ser Thr Pro Lys 
            580                 585                 590         


Thr Pro Asp Gly Gly His Ser Ser Gln Glu Ile Lys Ser Glu Thr Ser 
        595                 600                 605             


Ser Asn Pro Ser Ser Pro Glu Ile Cys Pro Asn Lys Glu Lys Pro Phe 
    610                 615                 620                 


Met Lys Leu Lys Glu Asn Gly Arg Ala Ile Ser Arg Ser Ser Ser Ser 
625                 630                 635                 640 


Thr Ser Ser Val Ser Ser Thr Ala Gly Glu Gly Glu Ala Met Glu Glu 
                645                 650                 655     


Gly Asp Ser Gly Gly Ser Gln Pro Ser Thr Thr Ser Pro Phe Lys Gln 
            660                 665                 670         


Glu Val Phe Val Tyr Ser Pro Ser Pro Ser Ser Glu Ser Pro Ser Leu 
        675                 680                 685             


Gly Ala Ala Ala Thr Pro Ile Ile Met Ser Arg Ser Pro Thr Asp Ala 
    690                 695                 700                 


Lys Ser Arg Asn Ser Pro Arg Ser Asn Leu Lys Phe Arg Phe Asp Lys 
705                 710                 715                 720 


Leu Ser His Ala Ser Ser Gly Ala Gly His 
                725                 730 


<210>  143
<211>  715
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Phe Gly Arg Lys Arg Ser Val Ser Phe Gly Gly Phe Gly Trp Ile 
1               5                   10                  15      


Asp Lys Thr Met Leu Ala Ser Leu Lys Val Lys Lys Gln Glu Leu Ala 
            20                  25                  30          


Asn Ser Ser Asp Ala Thr Leu Pro Asp Arg Pro Leu Ser Pro Pro Leu 
        35                  40                  45              


Thr Ala Pro Pro Thr Met Lys Ser Ser Glu Phe Phe Glu Met Leu Glu 
    50                  55                  60                  


Lys Met Gln Asp Asp Tyr Ile Pro Tyr Pro Ser Ile Asp Glu Val Val 
65                  70                  75                  80  


Glu Lys Gly Gly Pro Tyr Pro Gln Val Ile Leu Pro Gln Phe Gly Gly 
                85                  90                  95      


Tyr Trp Ile Glu Asp Pro Glu Asn Val Gly Thr Pro Thr Ser Leu Gly 
            100                 105                 110         


Ser Ser Ile Cys Glu Glu Glu Glu Glu Asp Asn Leu Ser Pro Asn Thr 
        115                 120                 125             


Phe Gly Tyr Lys Leu Glu Cys Lys Gly Glu Ala Arg Ala Tyr Arg Arg 
    130                 135                 140                 


His Phe Leu Gly Lys Asp His Leu Asn Phe Tyr Cys Thr Gly Ser Ser 
145                 150                 155                 160 


Leu Gly Asn Leu Ile Leu Ser Val Lys Cys Glu Glu Ala Glu Gly Ile 
                165                 170                 175     


Glu Tyr Leu Arg Val Ile Leu Arg Ser Lys Leu Lys Thr Val His Glu 
            180                 185                 190         


Arg Ile Pro Leu Ala Gly Leu Ser Lys Leu Pro Ser Val Pro Gln Ile 
        195                 200                 205             


Ala Lys Ala Phe Cys Asp Asp Ala Val Gly Leu Arg Phe Asn Pro Val 
    210                 215                 220                 


Leu Tyr Pro Lys Ala Ser Gln Met Ile Val Ser Tyr Asp Glu His Glu 
225                 230                 235                 240 


Val Asn Asn Thr Phe Lys Phe Gly Val Ile Tyr Gln Lys Ala Arg Gln 
                245                 250                 255     


Thr Leu Glu Glu Glu Leu Phe Gly Asn Asn Glu Glu Ser Pro Ala Phe 
            260                 265                 270         


Lys Glu Phe Leu Asp Leu Leu Gly Asp Thr Ile Thr Leu Gln Asp Phe 
        275                 280                 285             


Lys Gly Phe Arg Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Val 
    290                 295                 300                 


Glu Ser Val Tyr Thr Thr Phe Arg Asp Arg Glu Ile Met Phe His Val 
305                 310                 315                 320 


Ser Thr Lys Leu Pro Phe Thr Asp Gly Asp Ala Gln Gln Leu Gln Arg 
                325                 330                 335     


Lys Arg His Ile Gly Asn Asp Ile Val Ala Ile Ile Phe Gln Glu Glu 
            340                 345                 350         


Asn Thr Pro Phe Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala 
        355                 360                 365             


Tyr Ile Val Val Gln Val Glu Thr Pro Gly Thr Glu Thr Pro Ser Tyr 
    370                 375                 380                 


Lys Val Ser Val Thr Ala Arg Glu Asp Val Pro Thr Phe Gly Pro Pro 
385                 390                 395                 400 


Leu Pro Ser Pro Pro Val Phe Gln Lys Gly Pro Glu Phe Arg Glu Phe 
                405                 410                 415     


Leu Leu Thr Lys Leu Thr Asn Ala Glu Asn Ala Cys Cys Lys Ser Asp 
            420                 425                 430         


Lys Phe Ala Lys Leu Glu Asp Arg Thr Arg Ala Ala Leu Leu Asp Asn 
        435                 440                 445             


Leu His Asp Glu Leu His Ala His Thr Gln Ala Met Leu Gly Leu Gly 
    450                 455                 460                 


Pro Glu Glu Asp Lys Phe Glu Asn Gly Gly His Gly Gly Phe Leu Glu 
465                 470                 475                 480 


Ser Phe Lys Arg Ala Ile Arg Val Arg Ser His Ser Met Glu Thr Met 
                485                 490                 495     


Val Gly Gly Gln Lys Lys Ser His Ser Gly Gly Ile Pro Gly Ser Leu 
            500                 505                 510         


Ser Gly Gly Ile Ser His Asn Ser Met Glu Val Thr Lys Thr Thr Phe 
        515                 520                 525             


Ser Pro Pro Val Val Ala Ala Thr Val Lys Asn Gln Ser Arg Ser Pro 
    530                 535                 540                 


Ile Lys Arg Arg Ser Gly Leu Phe Pro Arg Leu His Thr Gly Ser Glu 
545                 550                 555                 560 


Gly Gln Gly Asp Ser Arg Ala Arg Cys Asp Ser Thr Ser Ser Thr Pro 
                565                 570                 575     


Lys Thr Pro Asp Gly Gly His Ser Ser Gln Glu Ile Lys Ser Glu Thr 
            580                 585                 590         


Ser Ser Asn Pro Ser Ser Pro Glu Ile Cys Pro Asn Lys Glu Lys Pro 
        595                 600                 605             


Phe Met Lys Leu Lys Glu Asn Gly Arg Ala Ile Ser Arg Ser Ser Ser 
    610                 615                 620                 


Ser Thr Ser Ser Val Ser Ser Thr Ala Gly Glu Gly Glu Ala Met Glu 
625                 630                 635                 640 


Glu Gly Asp Ser Gly Gly Ser Gln Pro Ser Thr Thr Ser Pro Phe Lys 
                645                 650                 655     


Gln Glu Val Phe Val Tyr Ser Pro Ser Pro Ser Ser Glu Ser Pro Ser 
            660                 665                 670         


Leu Gly Ala Ala Ala Thr Pro Ile Ile Met Ser Arg Ser Pro Thr Asp 
        675                 680                 685             


Ala Lys Ser Arg Asn Ser Pro Arg Ser Asn Leu Lys Phe Arg Phe Asp 
    690                 695                 700                 


Lys Leu Ser His Ala Ser Ser Gly Ala Gly His 
705                 710                 715 


<210>  144
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Leu Ala Ser Leu Lys Val Lys Lys Gln Glu Leu Ala Asn Ser Ser 
1               5                   10                  15      


Asp Ala Thr Leu Pro Asp Arg Pro Leu Ser Pro Pro Leu Thr Ala Pro 
            20                  25                  30          


Pro Thr Met Lys Ser Ser Glu Phe Phe Glu Met Leu Glu Lys Met Gln 
        35                  40                  45              


Gly Ile Lys Leu Glu Glu Gln Lys Pro Gly Pro Gln Lys Asn Lys Asp 
    50                  55                  60                  


Asp Tyr Ile Pro Tyr Pro Ser Ile Asp Glu Val Val Glu Lys Gly Gly 
65                  70                  75                  80  


Pro Tyr Pro Gln Val Ile Leu Pro Gln Phe Gly Gly Tyr Trp Ile Glu 
                85                  90                  95      


Asp Pro Glu Asn Val Gly Thr Pro Thr Ser Leu Gly Ser Ser Ile Cys 
            100                 105                 110         


Glu Glu Glu Glu Glu Asp Asn Leu Ser Pro Asn Thr Phe Gly Tyr Lys 
        115                 120                 125             


Leu Glu Cys Lys Gly Glu Ala Arg Ala Tyr Arg Arg His Phe Leu Gly 
    130                 135                 140                 


Lys Asp His Leu Asn Phe Tyr Cys Thr Gly Ser Ser Leu Gly Asn Leu 
145                 150                 155                 160 


Ile Leu Ser Val Lys Cys Glu Glu Ala Glu Gly Ile Glu Tyr Leu Arg 
                165                 170                 175     


Val Ile Leu Arg Ser Lys Leu Lys Thr Val His Glu Arg Ile Pro Leu 
            180                 185                 190         


Ala Gly Leu Ser Lys Leu Pro Ser Val Pro Gln Ile Ala Lys Ala Phe 
        195                 200                 205             


Cys Asp Asp Ala Val Gly Leu Arg Phe Asn Pro Val Leu Tyr Pro Lys 
    210                 215                 220                 


Ala Ser Gln Met Ile Val Ser Tyr Asp Glu His Glu Val Asn Asn Thr 
225                 230                 235                 240 


Phe Lys Phe Gly Val Ile Tyr Gln Lys Ala Arg Gln Thr Leu Glu Glu 
                245                 250                 255     


Glu Leu Phe Gly Asn Asn Glu Glu Ser Pro Ala Phe Lys Glu Phe Leu 
            260                 265                 270         


Asp Leu Leu Gly Asp Thr Ile Thr Leu Gln Asp Phe Lys Gly Phe Arg 
        275                 280                 285             


Gly Gly Leu Asp Val Thr His Gly Gln Thr Gly Val Glu Ser Val Tyr 
    290                 295                 300                 


Thr Thr Phe Arg Asp Arg Glu Ile Met Phe His Val Ser Thr Lys Leu 
305                 310                 315                 320 


Pro Phe Thr Asp Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile 
                325                 330                 335     


Gly Asn Asp Ile Val Ala Ile Ile Phe Gln Glu Glu Asn Thr Pro Phe 
            340                 345                 350         


Val Pro Asp Met Ile Ala Ser Asn Phe Leu His Ala Tyr Ile Val Val 
        355                 360                 365             


Gln Val Glu Thr Pro Gly Thr Glu Thr Pro Ser Tyr Lys Val Ser Val 
    370                 375                 380                 


Thr Ala Arg Glu Asp Val Pro Thr Phe Gly Pro Pro Leu Pro Ser Pro 
385                 390                 395                 400 


Pro Val Phe Gln Lys Gly Pro Glu Phe Arg Glu Phe Leu Leu Thr Lys 
                405                 410                 415     


Leu Thr Asn Ala Glu Asn Ala Cys Cys Lys Ser Asp Lys Phe Ala Lys 
            420                 425                 430         


Leu Glu Asp Arg Thr Arg Ala Ala Leu Leu Asp Asn Leu His Asp Glu 
        435                 440                 445             


Leu His Ala His Thr Gln Ala Met Leu Gly Leu Gly Pro Glu Glu Asp 
    450                 455                 460                 


Lys Phe Glu Asn Gly Gly His Gly Gly Phe Leu Glu Ser Phe Lys Arg 
465                 470                 475                 480 


Ala Ile Arg Val Arg Ser His Ser Met Glu Thr Met Val Gly Gly Gln 
                485                 490                 495     


Lys Lys Ser His Ser Gly Gly Ile Pro Gly Ser Leu Ser Gly Gly Ile 
            500                 505                 510         


Ser His Asn Ser Met Glu Val Thr Lys Thr Thr Phe Ser Pro Pro Val 
        515                 520                 525             


Val Ala Ala Thr Val Lys Asn Gln Ser Arg Ser Pro Ile Lys Arg Arg 
    530                 535                 540                 


Ser Gly Leu Phe Pro Arg Leu His Thr Gly Ser Glu Gly Gln Gly Asp 
545                 550                 555                 560 


Ser Arg Ala Arg Cys Asp Ser Thr Ser Ser Thr Pro Lys Thr Pro Asp 
                565                 570                 575     


Gly Gly His Ser Ser Gln Glu Ile Lys Ser Glu Thr Ser Ser Asn Pro 
            580                 585                 590         


Ser Ser Pro Glu Ile Cys Pro Asn Lys Glu Lys Pro Phe Met Lys Leu 
        595                 600                 605             


Lys Glu Asn Gly Arg Ala Ile Ser Arg Ser Ser Ser Ser Thr Ser Ser 
    610                 615                 620                 


Val Ser Ser Thr Ala Gly Glu Gly Glu Ala Met Glu Glu Gly Asp Ser 
625                 630                 635                 640 


Gly Gly Ser Gln Pro Ser Thr Thr Ser Pro Phe Lys Gln Glu Val Phe 
                645                 650                 655     


Val Tyr Ser Pro Ser Pro Ser Ser Glu Ser Pro Ser Leu Gly Ala Ala 
            660                 665                 670         


Ala Thr Pro Ile Ile Met Ser Arg Ser Pro Thr Asp Ala Lys Ser Arg 
        675                 680                 685             


Asn Ser Pro Arg Ser Asn Leu Lys Phe Arg Phe Asp Lys Leu Ser His 
    690                 695                 700                 


Ala Ser Ser Gly Ala Gly His 
705                 710     


<210>  145
<211>  2732
<212>  DNA
<213>  Homo sapiens

<400>  145
gactgcggga gtggagccgg cgagagagtg gcagcggggg ctgatggaag tgcagtgggg       60

gctggagagg gcaccctact gtatccagca tgctccaagg ccacagctct gtgttccagg      120

ccttgctggg gaccttcttc acctggggga tgacagcagc tggggcagct ctcgtgttcg      180

tattctctag tggacagagg cggatcttag atggaagtct tggctttgct gcaggggtca      240

tgttggcagc ttcctattgg tctcttctgg ccccagcagt tgagatggcc acgtcctctg      300

ggggcttcgg tgcctttgcc ttcttccctg tggctgttgg cttcaccctt ggagcggctt      360

ttgtctactt ggctgacctc ctgatgcctc acttgggtgc agcagaagac ccccagacga      420

ccctggcact gaacttcggc tctacgttga tgaagaagaa gtctgatcct gagggtcccg      480

cgctgctctt ccctgagagt gaactttcca tccggataga caagagtgag aatggtgagg      540

catatcagag aaagaaggcg gcagccactg gccttccaga gggtcctgct gtccctgtgc      600

cttctcgagg gaatctggca cagcccggcg gcagcagctg gaggaggatc gcactgctca      660

tcttggccat cactatacac aacgttccag agggtctcgc tgttggagtt ggatttgggg      720

ctatagaaaa gacggcatct gctacctttg agagtgccag gaatttggcc attggaatcg      780

ggatccagaa tttccccgag ggcctggctg tcagccttcc cttgcgaggg gcaggcttct      840

ccacctggag agctttctgg tatgggcagc tgagcggcat ggtggagccc ctggccgggg      900

tctttggtgc ctttgccgtg gtgctggctg agcccatcct gccctacgct ctggcctttg      960

ctgccggtgc catggtctac gtggtcatgg acgacatcat ccccgaagcc cagatcagtg     1020

gtaatgggaa actggcatcc tgggcctcca tcctgggatt tgtagtgatg atgtcactgg     1080

acgttggcct gggctagggc tgagacgctt cggaccccgg gaaaggccat acgaagaaac     1140

agcagtggtt ggcttctatg ggacaacaag cttctttctt cacattaaaa cttttttcct     1200

tcctctcttc ttcatctcat tatcctgatt gactctgatt ataatagaac catttttact     1260

ttgctttgag ggagattttt gatttaatgg ggaattttaa ggtgtcatgg aaatacagat     1320

tctttgtttt ggccactgaa tggactctct cttcagtggg attatcaagg aacttcagat     1380

cagggaaatc tccacttcgg gaccttctat ctgcctccca actcctcaag gtcacctata     1440

gaagcgagct accaaaagac gtctcctaag cattttggtg gcctagtgac tcagggcaga     1500

gtggccagca cacctctcat ccgcccctcc tgctccatca ctgctgagcc tctccccatc     1560

tagaatgttg gaactggagc atcataaaga tagcaagcta ccttccaagg ccgagccagc     1620

ccagagagga gcatgtcttc ctttacctcc ccctaaggag atactacatg ggagggggac     1680

acagaaaaag ggaaggaaat tggctagtct ggcttttttt tttttttttt ttaaaggcaa     1740

agattgacat tattgaagga aaggggatga ggacaactgt gaactcacag tgagccctgt     1800

ggaaagaaga gacagacaga gtgtgggttt gttcggaggc ctctgctgtc aatggattcc     1860

aggagcaagg ccatttgtcg cgctttccaa atttcttagg catttatttt gataagttta     1920

tagccatcat gtttctaaga gacttggaga caccagcaaa ctgctagaac tcaaactctt     1980

caattactca aagaaggagc catttcagtt aactcaagtg aatgaaagag ttttggaatc     2040

tgctgtgggt ccttccctgt tgaccatttg gtaacttata atctgacaaa aactcttgag     2100

ctgcaacagg ccttgccaga gggctcagga tgggaaagga agaaggggat aggaaaagaa     2160

gaggtaattt tacatttccc ctttaaagta aattttagcc aactcatcat tctgaaatgt     2220

ccctataaag aatgagtcga actagaccag aagccagcct actccttctt acatagcttc     2280

tccaacaggg gtagcaatga cctgtccact tcaaacacag ataaggcctg ccatcctcat     2340

tggttaaagg cacacgtgag actttcagtg ggctctgctg agaaggaagg cagcccagga     2400

gtcaggtatg caggcattgc attgtcagtg tctgctctca gagtttacac attcaattgc     2460

ttccaagggt gaatctcctg ctctgtgaat gctatcagac cccaaaggcc aaccttgggc     2520

tgggtctatg tacgttcttc cgaagcactg atgatcaaaa ttgaagacac attcagaggt     2580

ttgattggtt gagattaact ggtgtggtgg ttggtgtatg tatgttttat ttttatgtct     2640

ttgtatgtag ttctacataa tgcaaattgt gctttctgat ggacaagacc tcataactgt     2700

gattaatatc aataaaaagg ggatgttgtg ga                                   2732


<210>  146
<211>  2869
<212>  DNA
<213>  Homo sapiens

<400>  146
gactgcggga gtggagccgg cgagagagtg gcagcggggg ctgatggaag tgcagtgggg       60

gctggagagg gcaccctagt gagttggctt ttctctcctt cggtgccttt ggttgggctc      120

gaggcccggg gtcggaggcc atcaggacaa gagtgtggga cttggaaggg cagccacctg      180

gagcttggaa ggggctgtat ccagcatgct ccaaggccac agctctgtgt tccaggcctt      240

gctggggacc ttcttcacct gggggatgac agcagctggg gcagctctcg tgttcgtatt      300

ctctagtgga cagaggcgga tcttagatgg aagtcttggc tttgctgcag gggtcatgtt      360

ggcagcttcc tattggtctc ttctggcccc agcagttgag atggccacgt cctctggggg      420

cttcggtgcc tttgccttct tccctgtggc tgttggcttc acccttggag cggcttttgt      480

ctacttggct gacctcctga tgcctcactt gggtgcagca gaagaccccc agacgaccct      540

ggcactgaac ttcggctcta cgttgatgaa gaagaagtct gatcctgagg gtcccgcgct      600

gctcttccct gagagtgaac tttccatccg gataggtaga gctgggcttc tttcagacaa      660

gagtgagaat ggtgaggcat atcagagaaa gaaggcggca gccactggcc ttccagaggg      720

tcctgctgtc cctgtgcctt ctcgagggaa tctggcacag cccggcggca gcagctggag      780

gaggatcgca ctgctcatct tggccatcac tatacacaac gttccagagg gtctcgctgt      840

tggagttgga tttggggcta tagaaaagac ggcatctgct acctttgaga gtgccaggaa      900

tttggccatt ggaatcggga tccagaattt ccccgagggc ctggctgtca gccttccctt      960

gcgaggggca ggcttctcca cctggagagc tttctggtat gggcagctga gcggcatggt     1020

ggagcccctg gccggggtct ttggtgcctt tgccgtggtg ctggctgagc ccatcctgcc     1080

ctacgctctg gcctttgctg ccggtgccat ggtctacgtg gtcatggacg acatcatccc     1140

cgaagcccag atcagtggta atgggaaact ggcatcctgg gcctccatcc tgggatttgt     1200

agtgatgatg tcactggacg ttggcctggg ctagggctga gacgcttcgg accccgggaa     1260

aggccatacg aagaaacagc agtggttggc ttctatggga caacaagctt ctttcttcac     1320

attaaaactt ttttccttcc tctcttcttc atctcattat cctgattgac tctgattata     1380

atagaaccat ttttactttg ctttgaggga gatttttgat ttaatgggga attttaaggt     1440

gtcatggaaa tacagattct ttgttttggc cactgaatgg actctctctt cagtgggatt     1500

atcaaggaac ttcagatcag ggaaatctcc acttcgggac cttctatctg cctcccaact     1560

cctcaaggtc acctatagaa gcgagctacc aaaagacgtc tcctaagcat tttggtggcc     1620

tagtgactca gggcagagtg gccagcacac ctctcatccg cccctcctgc tccatcactg     1680

ctgagcctct ccccatctag aatgttggaa ctggagcatc ataaagatag caagctacct     1740

tccaaggccg agccagccca gagaggagca tgtcttcctt tacctccccc taaggagata     1800

ctacatggga gggggacaca gaaaaaggga aggaaattgg ctagtctggc tttttttttt     1860

ttttttttta aaggcaaaga ttgacattat tgaaggaaag gggatgagga caactgtgaa     1920

ctcacagtga gccctgtgga aagaagagac agacagagtg tgggtttgtt cggaggcctc     1980

tgctgtcaat ggattccagg agcaaggcca tttgtcgcgc tttccaaatt tcttaggcat     2040

ttattttgat aagtttatag ccatcatgtt tctaagagac ttggagacac cagcaaactg     2100

ctagaactca aactcttcaa ttactcaaag aaggagccat ttcagttaac tcaagtgaat     2160

gaaagagttt tggaatctgc tgtgggtcct tccctgttga ccatttggta acttataatc     2220

tgacaaaaac tcttgagctg caacaggcct tgccagaggg ctcaggatgg gaaaggaaga     2280

aggggatagg aaaagaagag gtaattttac atttcccctt taaagtaaat tttagccaac     2340

tcatcattct gaaatgtccc tataaagaat gagtcgaact agaccagaag ccagcctact     2400

ccttcttaca tagcttctcc aacaggggta gcaatgacct gtccacttca aacacagata     2460

aggcctgcca tcctcattgg ttaaaggcac acgtgagact ttcagtgggc tctgctgaga     2520

aggaaggcag cccaggagtc aggtatgcag gcattgcatt gtcagtgtct gctctcagag     2580

tttacacatt caattgcttc caagggtgaa tctcctgctc tgtgaatgct atcagacccc     2640

aaaggccaac cttgggctgg gtctatgtac gttcttccga agcactgatg atcaaaattg     2700

aagacacatt cagaggtttg attggttgag attaactggt gtggtggttg gtgtatgtat     2760

gttttatttt tatgtctttg tatgtagttc tacataatgc aaattgtgct ttctgatgga     2820

caagacctca taactgtgat taatatcaat aaaaagggga tgttgtgga                 2869


<210>  147
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Leu Gln Gly His Ser Ser Val Phe Gln Ala Leu Leu Gly Thr Phe 
1               5                   10                  15      


Phe Thr Trp Gly Met Thr Ala Ala Gly Ala Ala Leu Val Phe Val Phe 
            20                  25                  30          


Ser Ser Gly Gln Arg Arg Ile Leu Asp Gly Ser Leu Gly Phe Ala Ala 
        35                  40                  45              


Gly Val Met Leu Ala Ala Ser Tyr Trp Ser Leu Leu Ala Pro Ala Val 
    50                  55                  60                  


Glu Met Ala Thr Ser Ser Gly Gly Phe Gly Ala Phe Ala Phe Phe Pro 
65                  70                  75                  80  


Val Ala Val Gly Phe Thr Leu Gly Ala Ala Phe Val Tyr Leu Ala Asp 
                85                  90                  95      


Leu Leu Met Pro His Leu Gly Ala Ala Glu Asp Pro Gln Thr Thr Leu 
            100                 105                 110         


Ala Leu Asn Phe Gly Ser Thr Leu Met Lys Lys Lys Ser Asp Pro Glu 
        115                 120                 125             


Gly Pro Ala Leu Leu Phe Pro Glu Ser Glu Leu Ser Ile Arg Ile Asp 
    130                 135                 140                 


Lys Ser Glu Asn Gly Glu Ala Tyr Gln Arg Lys Lys Ala Ala Ala Thr 
145                 150                 155                 160 


Gly Leu Pro Glu Gly Pro Ala Val Pro Val Pro Ser Arg Gly Asn Leu 
                165                 170                 175     


Ala Gln Pro Gly Gly Ser Ser Trp Arg Arg Ile Ala Leu Leu Ile Leu 
            180                 185                 190         


Ala Ile Thr Ile His Asn Val Pro Glu Gly Leu Ala Val Gly Val Gly 
        195                 200                 205             


Phe Gly Ala Ile Glu Lys Thr Ala Ser Ala Thr Phe Glu Ser Ala Arg 
    210                 215                 220                 


Asn Leu Ala Ile Gly Ile Gly Ile Gln Asn Phe Pro Glu Gly Leu Ala 
225                 230                 235                 240 


Val Ser Leu Pro Leu Arg Gly Ala Gly Phe Ser Thr Trp Arg Ala Phe 
                245                 250                 255     


Trp Tyr Gly Gln Leu Ser Gly Met Val Glu Pro Leu Ala Gly Val Phe 
            260                 265                 270         


Gly Ala Phe Ala Val Val Leu Ala Glu Pro Ile Leu Pro Tyr Ala Leu 
        275                 280                 285             


Ala Phe Ala Ala Gly Ala Met Val Tyr Val Val Met Asp Asp Ile Ile 
    290                 295                 300                 


Pro Glu Ala Gln Ile Ser Gly Asn Gly Lys Leu Ala Ser Trp Ala Ser 
305                 310                 315                 320 


Ile Leu Gly Phe Val Val Met Met Ser Leu Asp Val Gly Leu Gly 
                325                 330                 335 


<210>  148
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Leu Gln Gly His Ser Ser Val Phe Gln Ala Leu Leu Gly Thr Phe 
1               5                   10                  15      


Phe Thr Trp Gly Met Thr Ala Ala Gly Ala Ala Leu Val Phe Val Phe 
            20                  25                  30          


Ser Ser Gly Gln Arg Arg Ile Leu Asp Gly Ser Leu Gly Phe Ala Ala 
        35                  40                  45              


Gly Val Met Leu Ala Ala Ser Tyr Trp Ser Leu Leu Ala Pro Ala Val 
    50                  55                  60                  


Glu Met Ala Thr Ser Ser Gly Gly Phe Gly Ala Phe Ala Phe Phe Pro 
65                  70                  75                  80  


Val Ala Val Gly Phe Thr Leu Gly Ala Ala Phe Val Tyr Leu Ala Asp 
                85                  90                  95      


Leu Leu Met Pro His Leu Gly Ala Ala Glu Asp Pro Gln Thr Thr Leu 
            100                 105                 110         


Ala Leu Asn Phe Gly Ser Thr Leu Met Lys Lys Lys Ser Asp Pro Glu 
        115                 120                 125             


Gly Pro Ala Leu Leu Phe Pro Glu Ser Glu Leu Ser Ile Arg Ile Gly 
    130                 135                 140                 


Arg Ala Gly Leu Leu Ser Asp Lys Ser Glu Asn Gly Glu Ala Tyr Gln 
145                 150                 155                 160 


Arg Lys Lys Ala Ala Ala Thr Gly Leu Pro Glu Gly Pro Ala Val Pro 
                165                 170                 175     


Val Pro Ser Arg Gly Asn Leu Ala Gln Pro Gly Gly Ser Ser Trp Arg 
            180                 185                 190         


Arg Ile Ala Leu Leu Ile Leu Ala Ile Thr Ile His Asn Val Pro Glu 
        195                 200                 205             


Gly Leu Ala Val Gly Val Gly Phe Gly Ala Ile Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ala Thr Phe Glu Ser Ala Arg Asn Leu Ala Ile Gly Ile Gly Ile Gln 
225                 230                 235                 240 


Asn Phe Pro Glu Gly Leu Ala Val Ser Leu Pro Leu Arg Gly Ala Gly 
                245                 250                 255     


Phe Ser Thr Trp Arg Ala Phe Trp Tyr Gly Gln Leu Ser Gly Met Val 
            260                 265                 270         


Glu Pro Leu Ala Gly Val Phe Gly Ala Phe Ala Val Val Leu Ala Glu 
        275                 280                 285             


Pro Ile Leu Pro Tyr Ala Leu Ala Phe Ala Ala Gly Ala Met Val Tyr 
    290                 295                 300                 


Val Val Met Asp Asp Ile Ile Pro Glu Ala Gln Ile Ser Gly Asn Gly 
305                 310                 315                 320 


Lys Leu Ala Ser Trp Ala Ser Ile Leu Gly Phe Val Val Met Met Ser 
                325                 330                 335     


Leu Asp Val Gly Leu Gly 
            340         


<210>  149
<211>  4510
<212>  DNA
<213>  Homo sapiens

<400>  149
gctgaggcca ggagggcgca ctggggattg gaggcgaggg aagtgcaggg cgcatcccag       60

gcggcagggc tcccagcatc ggcagtcgcc atcaccgcca gaccgcagag acaggttcgg      120

atccgcggtc ctcttgcctc tttccaggcc tcgatgagtg ttaaatcgcc atttaatgtg      180

atgtcaagaa ataatttgga agcacctcct tgtaagatga cagagccatt taattttgag      240

aaaaatgaaa acaagcttcc accacatgag tctttaagaa gtcctggaac acttcctaac      300

caccctaatt tcaggctgaa aagctcagag aatggaaata aaaagaacaa ttttttgctt      360

tgtgagcaaa ccaaacaata tttggctagt caggaagaca attcagtttc ttcaaacccg      420

aatggcatca acggagaagt agttggctcc aaaggagaca ggaaaaaatt gccagcagga      480

aactcagtgt caccaccaag tgctgaaagt aattcaccac ccaaagaagt gaatattaag      540

cctggaaata atgtacgtcc tgcaaaatca aaaaaactaa acaagttggt cgagaattcc      600

ttgtccataa gtaatccagg gctcttcacc tccttaggac ctcctcttcg gtccacaact      660

tgccatcgct gtggcctatt tggatcgctg aggtgctctc agtgcaagca gacctactat      720

tgctccacag catgtcaaag aagagactgg tctgcacaca gcatcgtgtg caggcctgtt      780

cagccaaatt tccacaaact tgaaaataaa tcatctattg aaacaaagga tgtggaggta      840

aacaataaga gtgactgtcc acttggagtt actaaggaaa tagccatttg ggctgagaga      900

ataatgtttt ctgatttgag aagtctacaa ctcaagaaaa ccatggaaat aaagggtacg      960

gttaccgaat tcaaacaccc aggggacttc tacgtgcagt tatattcttc agaagtttta     1020

gaatacatga accaactctc tgccagctta aaagaaacat atgcaaatgt gcatgaaaaa     1080

gactatattc ctgttaaggg ggaagtttgt attgccaagt acactgttga tcagacctgg     1140

aacagagcaa tcatacaaaa cgttgatgtg cagcaaaaga aggcacatgt cttatatatt     1200

gattatggaa atgaagaaat aattccatta aacagaattt accacctcaa caggaacatt     1260

gacttgtttc ctccttgtgc cataaagtgc tttgtagcca atgttatccc agcagaaggg     1320

aattggagca gtgattgtat caaagctact aaaccactgt taatggagca gtactgctcc     1380

ataaagattg tcgacatctt ggaagaggaa gtggttacct ttgctgtaga agttgagctg     1440

ccaaattcag gaaaactttt agaccatgtg cttatagaaa tgggatatgg cttgaaaccc     1500

agtggacaag attctaagaa ggaaaatgca gatcaaagtg atcctgaaga tgttggaaaa     1560

atgacaactg aaaacaacat tgtcgtagac aaaagtgacc taatcccaaa agtgttaact     1620

ttgaatgtag gtgatgagtt ttgtggtgtg gttgcccaca ttcaaacacc agaagacttc     1680

ttttgtcaac aactgcaaag tggccgaaag cttgctgaac ttcaggcatc ccttagcaag     1740

tactgtgatc agttgcctcc acgctctgat ttttatccag ccattggtga tatatgttgt     1800

gctcagttct cagaggatga tcagtggtac cgtgcctctg ttttggctta cgcttctgaa     1860

gaatctgtac tggtcggata tgtagattat ggaaactttg aaatccttag tttgatgaga     1920

ctttgtccca taatcccaaa gttgttggaa ttgccaatgc aagctataaa gtgtgtacta     1980

gcaggagtaa agccatcatt aggaatttgg actccagaag ctatttgtct catgaaaaaa     2040

cttgtacaga acaaaataat cacagtgaaa gtggtggaca agttggaaaa cagttccctg     2100

gtggagctta ttgataaatc cgagacgcct catgtcagtg ttagcaaagt tctcctagat     2160

gcaggctttg ctgtgggaga acagagtatg gtgacagata aacccagtga cgtgaaagaa     2220

accagtgttc ccttgggtgt ggaaggaaaa gtaaatccat tggagtggac atgggttgaa     2280

cttggtgttg accaaacagt agatgttgtg gtctgtgtga tatatagtcc tggagaattt     2340

tattgccatg tgcttaaaga ggatgcttta aagaaactca atgatttgaa caagtcatta     2400

gcagaacact gccagcagaa gttacctaat ggtttcaagg cagagatagg acaaccttgt     2460

tgtgcttttt ttgcaggtga tggtagttgg tatcgtgctt tagtcaagga aatcttacca     2520

aatggacatg ttaaagtaca ttttgtggat tatggaaaca tcgaagaagt tactgcagat     2580

gaactccgaa tgatatcatc aacattttta aaccttccct ttcagggaat acggtgccag     2640

ttagcagata tacagtctag aaacaaacat tggtctgaag aagccataac aagattccag     2700

atgtgtgttg ctgggataaa attgcaagcc agagtggttg aagtcactga aaatgggata     2760

ggagttgaac tcaccgatct ctccacttgt tatcccagaa taattagtga tgttctgatt     2820

gatgaacatc tggttttaaa atctgcttca ccacataaag acttaccaaa tgacagactt     2880

gttaataaac atgagcttca agttcatgta cagggacttc aagctacctc ttcagctgag     2940

caatggaaga cgatagaatt gccagtggat aaaactatac aagcaaatgt attagaaatc     3000

ataagcccaa acttgtttta tgctctacca aaagggatgc cagaaaatca ggaaaagctg     3060

tgcatgttga cagctgaatt attagaatac tgcaatgctc cgaaaagtcg accaccctat     3120

agaccaagaa ttggagacgc atgctgtgcc aaatacacaa gtgatgattt ttggtatcgt     3180

gcagttgttc tggggacatc agacactgat gtggaagtgc tctatgcaga ctatggaaac     3240

attgaaaccc tgcctctttg cagagtgcaa ccaatcacct ctagccacct ggcgcttcct     3300

ttccaaatta ttagatgttc acttgaagga ttaatggaat tgaatggaag ctcttctcaa     3360

ttaataataa tgctattaaa aaatttcatg ttgaatcaga atgtaatgct ttctgtgaaa     3420

ggaattacaa agaatgtcca tacagtgtca gttgagaaat gttctgagaa tgggactgtc     3480

gatgtagctg ataagctagt gacatttggt ctggcaaaaa acatcacacc tcaaaggcag     3540

agtgctttaa atacagaaaa gatgtatagg atgaattgct gctgcacaga gttacagaaa     3600

caagttgaaa aacatgaaca tattcttctc ttcctcttaa acaattcaac caatcaaaat     3660

aaatttattg aaatgaaaaa actgttaaaa aaaacagcat ctcttggagg taaaccctta     3720

tgagacagga aacagcaaag gctagcttta ggagagaaag tacagcacct ggtgttttta     3780

tttatgagaa ccttttcttt gtccactttc tctgtaatga ccttctatcc ctccgttttt     3840

gcctgcctgc cattctccta ttaggttggt ggtttttatt ttcctctaag ttccttccac     3900

caaataaata ttacgtaaaa aattcatacc aaatcaatga gaatactggc aaggaataca     3960

tagggacttt ctgctatata tgtaactttt tattacttaa aggtaccgaa ggaaggccag     4020

gtgcagtggc tcacgcccag cactttggga ggctgaggtg ggaggatccc ttgaggccag     4080

gagttcaagg ttacagtgag ctatgatagt gccactgcac tccagcctgg gtgacagatt     4140

ttgtcttaaa aaaaaaaaaa aaaaagttga tatgagtttt attttctgtc cgtttgaaat     4200

attttgtaat attccctgca ttctctgtcg tctgcctctt ccacataatg tcctttgctt     4260

tcatgtttgt tatcttcttt ttctgttcac tcagaggtca tcaatttctt tctctccgtc     4320

cttaattgga ttatttttct tttggccttt gggcacagag tctgacctct ggaccactct     4380

aactggagaa ggaactttat gttccctctc ctgctgtgtc cacaacctta gaaatctgta     4440

gctagatttt tgttgttata gatagaattt actgtttctg aaacccaaat acagttatca     4500

gtttaaggtt                                                            4510


<210>  150
<211>  1189
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Ser Val Lys Ser Pro Phe Asn Val Met Ser Arg Asn Asn Leu Glu 
1               5                   10                  15      


Ala Pro Pro Cys Lys Met Thr Glu Pro Phe Asn Phe Glu Lys Asn Glu 
            20                  25                  30          


Asn Lys Leu Pro Pro His Glu Ser Leu Arg Ser Pro Gly Thr Leu Pro 
        35                  40                  45              


Asn His Pro Asn Phe Arg Leu Lys Ser Ser Glu Asn Gly Asn Lys Lys 
    50                  55                  60                  


Asn Asn Phe Leu Leu Cys Glu Gln Thr Lys Gln Tyr Leu Ala Ser Gln 
65                  70                  75                  80  


Glu Asp Asn Ser Val Ser Ser Asn Pro Asn Gly Ile Asn Gly Glu Val 
                85                  90                  95      


Val Gly Ser Lys Gly Asp Arg Lys Lys Leu Pro Ala Gly Asn Ser Val 
            100                 105                 110         


Ser Pro Pro Ser Ala Glu Ser Asn Ser Pro Pro Lys Glu Val Asn Ile 
        115                 120                 125             


Lys Pro Gly Asn Asn Val Arg Pro Ala Lys Ser Lys Lys Leu Asn Lys 
    130                 135                 140                 


Leu Val Glu Asn Ser Leu Ser Ile Ser Asn Pro Gly Leu Phe Thr Ser 
145                 150                 155                 160 


Leu Gly Pro Pro Leu Arg Ser Thr Thr Cys His Arg Cys Gly Leu Phe 
                165                 170                 175     


Gly Ser Leu Arg Cys Ser Gln Cys Lys Gln Thr Tyr Tyr Cys Ser Thr 
            180                 185                 190         


Ala Cys Gln Arg Arg Asp Trp Ser Ala His Ser Ile Val Cys Arg Pro 
        195                 200                 205             


Val Gln Pro Asn Phe His Lys Leu Glu Asn Lys Ser Ser Ile Glu Thr 
    210                 215                 220                 


Lys Asp Val Glu Val Asn Asn Lys Ser Asp Cys Pro Leu Gly Val Thr 
225                 230                 235                 240 


Lys Glu Ile Ala Ile Trp Ala Glu Arg Ile Met Phe Ser Asp Leu Arg 
                245                 250                 255     


Ser Leu Gln Leu Lys Lys Thr Met Glu Ile Lys Gly Thr Val Thr Glu 
            260                 265                 270         


Phe Lys His Pro Gly Asp Phe Tyr Val Gln Leu Tyr Ser Ser Glu Val 
        275                 280                 285             


Leu Glu Tyr Met Asn Gln Leu Ser Ala Ser Leu Lys Glu Thr Tyr Ala 
    290                 295                 300                 


Asn Val His Glu Lys Asp Tyr Ile Pro Val Lys Gly Glu Val Cys Ile 
305                 310                 315                 320 


Ala Lys Tyr Thr Val Asp Gln Thr Trp Asn Arg Ala Ile Ile Gln Asn 
                325                 330                 335     


Val Asp Val Gln Gln Lys Lys Ala His Val Leu Tyr Ile Asp Tyr Gly 
            340                 345                 350         


Asn Glu Glu Ile Ile Pro Leu Asn Arg Ile Tyr His Leu Asn Arg Asn 
        355                 360                 365             


Ile Asp Leu Phe Pro Pro Cys Ala Ile Lys Cys Phe Val Ala Asn Val 
    370                 375                 380                 


Ile Pro Ala Glu Gly Asn Trp Ser Ser Asp Cys Ile Lys Ala Thr Lys 
385                 390                 395                 400 


Pro Leu Leu Met Glu Gln Tyr Cys Ser Ile Lys Ile Val Asp Ile Leu 
                405                 410                 415     


Glu Glu Glu Val Val Thr Phe Ala Val Glu Val Glu Leu Pro Asn Ser 
            420                 425                 430         


Gly Lys Leu Leu Asp His Val Leu Ile Glu Met Gly Tyr Gly Leu Lys 
        435                 440                 445             


Pro Ser Gly Gln Asp Ser Lys Lys Glu Asn Ala Asp Gln Ser Asp Pro 
    450                 455                 460                 


Glu Asp Val Gly Lys Met Thr Thr Glu Asn Asn Ile Val Val Asp Lys 
465                 470                 475                 480 


Ser Asp Leu Ile Pro Lys Val Leu Thr Leu Asn Val Gly Asp Glu Phe 
                485                 490                 495     


Cys Gly Val Val Ala His Ile Gln Thr Pro Glu Asp Phe Phe Cys Gln 
            500                 505                 510         


Gln Leu Gln Ser Gly Arg Lys Leu Ala Glu Leu Gln Ala Ser Leu Ser 
        515                 520                 525             


Lys Tyr Cys Asp Gln Leu Pro Pro Arg Ser Asp Phe Tyr Pro Ala Ile 
    530                 535                 540                 


Gly Asp Ile Cys Cys Ala Gln Phe Ser Glu Asp Asp Gln Trp Tyr Arg 
545                 550                 555                 560 


Ala Ser Val Leu Ala Tyr Ala Ser Glu Glu Ser Val Leu Val Gly Tyr 
                565                 570                 575     


Val Asp Tyr Gly Asn Phe Glu Ile Leu Ser Leu Met Arg Leu Cys Pro 
            580                 585                 590         


Ile Ile Pro Lys Leu Leu Glu Leu Pro Met Gln Ala Ile Lys Cys Val 
        595                 600                 605             


Leu Ala Gly Val Lys Pro Ser Leu Gly Ile Trp Thr Pro Glu Ala Ile 
    610                 615                 620                 


Cys Leu Met Lys Lys Leu Val Gln Asn Lys Ile Ile Thr Val Lys Val 
625                 630                 635                 640 


Val Asp Lys Leu Glu Asn Ser Ser Leu Val Glu Leu Ile Asp Lys Ser 
                645                 650                 655     


Glu Thr Pro His Val Ser Val Ser Lys Val Leu Leu Asp Ala Gly Phe 
            660                 665                 670         


Ala Val Gly Glu Gln Ser Met Val Thr Asp Lys Pro Ser Asp Val Lys 
        675                 680                 685             


Glu Thr Ser Val Pro Leu Gly Val Glu Gly Lys Val Asn Pro Leu Glu 
    690                 695                 700                 


Trp Thr Trp Val Glu Leu Gly Val Asp Gln Thr Val Asp Val Val Val 
705                 710                 715                 720 


Cys Val Ile Tyr Ser Pro Gly Glu Phe Tyr Cys His Val Leu Lys Glu 
                725                 730                 735     


Asp Ala Leu Lys Lys Leu Asn Asp Leu Asn Lys Ser Leu Ala Glu His 
            740                 745                 750         


Cys Gln Gln Lys Leu Pro Asn Gly Phe Lys Ala Glu Ile Gly Gln Pro 
        755                 760                 765             


Cys Cys Ala Phe Phe Ala Gly Asp Gly Ser Trp Tyr Arg Ala Leu Val 
    770                 775                 780                 


Lys Glu Ile Leu Pro Asn Gly His Val Lys Val His Phe Val Asp Tyr 
785                 790                 795                 800 


Gly Asn Ile Glu Glu Val Thr Ala Asp Glu Leu Arg Met Ile Ser Ser 
                805                 810                 815     


Thr Phe Leu Asn Leu Pro Phe Gln Gly Ile Arg Cys Gln Leu Ala Asp 
            820                 825                 830         


Ile Gln Ser Arg Asn Lys His Trp Ser Glu Glu Ala Ile Thr Arg Phe 
        835                 840                 845             


Gln Met Cys Val Ala Gly Ile Lys Leu Gln Ala Arg Val Val Glu Val 
    850                 855                 860                 


Thr Glu Asn Gly Ile Gly Val Glu Leu Thr Asp Leu Ser Thr Cys Tyr 
865                 870                 875                 880 


Pro Arg Ile Ile Ser Asp Val Leu Ile Asp Glu His Leu Val Leu Lys 
                885                 890                 895     


Ser Ala Ser Pro His Lys Asp Leu Pro Asn Asp Arg Leu Val Asn Lys 
            900                 905                 910         


His Glu Leu Gln Val His Val Gln Gly Leu Gln Ala Thr Ser Ser Ala 
        915                 920                 925             


Glu Gln Trp Lys Thr Ile Glu Leu Pro Val Asp Lys Thr Ile Gln Ala 
    930                 935                 940                 


Asn Val Leu Glu Ile Ile Ser Pro Asn Leu Phe Tyr Ala Leu Pro Lys 
945                 950                 955                 960 


Gly Met Pro Glu Asn Gln Glu Lys Leu Cys Met Leu Thr Ala Glu Leu 
                965                 970                 975     


Leu Glu Tyr Cys Asn Ala Pro Lys Ser Arg Pro Pro Tyr Arg Pro Arg 
            980                 985                 990         


Ile Gly Asp Ala Cys Cys Ala Lys  Tyr Thr Ser Asp Asp  Phe Trp Tyr 
        995                 1000                 1005             


Arg Ala  Val Val Leu Gly Thr  Ser Asp Thr Asp Val  Glu Val Leu 
    1010                 1015                 1020             


Tyr Ala  Asp Tyr Gly Asn Ile  Glu Thr Leu Pro Leu  Cys Arg Val 
    1025                 1030                 1035             


Gln Pro  Ile Thr Ser Ser His  Leu Ala Leu Pro Phe  Gln Ile Ile 
    1040                 1045                 1050             


Arg Cys  Ser Leu Glu Gly Leu  Met Glu Leu Asn Gly  Ser Ser Ser 
    1055                 1060                 1065             


Gln Leu  Ile Ile Met Leu Leu  Lys Asn Phe Met Leu  Asn Gln Asn 
    1070                 1075                 1080             


Val Met  Leu Ser Val Lys Gly  Ile Thr Lys Asn Val  His Thr Val 
    1085                 1090                 1095             


Ser Val  Glu Lys Cys Ser Glu  Asn Gly Thr Val Asp  Val Ala Asp 
    1100                 1105                 1110             


Lys Leu  Val Thr Phe Gly Leu  Ala Lys Asn Ile Thr  Pro Gln Arg 
    1115                 1120                 1125             


Gln Ser  Ala Leu Asn Thr Glu  Lys Met Tyr Arg Met  Asn Cys Cys 
    1130                 1135                 1140             


Cys Thr  Glu Leu Gln Lys Gln  Val Glu Lys His Glu  His Ile Leu 
    1145                 1150                 1155             


Leu Phe  Leu Leu Asn Asn Ser  Thr Asn Gln Asn Lys  Phe Ile Glu 
    1160                 1165                 1170             


Met Lys  Lys Leu Leu Lys Lys  Thr Ala Ser Leu Gly  Gly Lys Pro 
    1175                 1180                 1185             


Leu 
    


<210>  151
<211>  4216
<212>  DNA
<213>  Homo sapiens

<400>  151
agtttctctt ctcggccacc tcctgcatag agggtaccat tctgcgctgc tgcaagttac       60

ggaatgaaaa attagaacaa cagaaacatg gaaaacatgt tccttcagtc gtcaatgctg      120

acctgcattt tcctgctaat atctggttcc tgtgagttat gcgccgaaga aaatttttct      180

agaagctatc cttgtgatga gaaaaagcaa aatgactcag ttattgcaga gtgcagcaat      240

cgtcgactac aggaagttcc ccaaacggtg ggcaaatatg tgacagaact agacctgtct      300

gataatttca tcacacacat aacgaatgaa tcatttcaag ggctgcaaaa tctcactaaa      360

ataaatctaa accacaaccc caatgtacag caccagaacg gaaatcccgg tatacaatca      420

aatggcttga atatcacaga cggggcattc ctcaacctaa aaaacctaag ggagttactg      480

cttgaagaca accagttacc ccaaataccc tctggtttgc cagagtcttt gacagaactt      540

agtctaattc aaaacaatat atacaacata actaaagagg gcatttcaag acttataaac      600

ttgaaaaatc tctatttggc ctggaactgc tattttaaca aagtttgcga gaaaactaac      660

atagaagatg gagtatttga aacgctgaca aatttggagt tgctatcact atctttcaat      720

tctctttcac acgtgccacc caaactgcca agctccctac gcaaactttt tctgagcaac      780

acccagatca aatacattag tgaagaagat ttcaagggat tgataaattt aacattacta      840

gatttaagcg ggaactgtcc gaggtgcttc aatgccccat ttccatgcgt gccttgtgat      900

ggtggtgctt caattaatat agatcgtttt gcttttcaaa acttgaccca acttcgatac      960

ctaaacctct ctagcacttc cctcaggaag attaatgctg cctggtttaa aaatatgcct     1020

catctgaagg tgctggatct tgaattcaac tatttagtgg gagaaatagc ctctggggca     1080

tttttaacga tgctgccccg cttagaaata cttgacttgt cttttaacta tataaagggg     1140

agttatccac agcatattaa tatttccaga aacttctcta aacttttgtc tctacgggca     1200

ttgcatttaa gaggttatgt gttccaggaa ctcagagaag atgatttcca gcccctgatg     1260

cagcttccaa acttatcgac tatcaacttg ggtattaatt ttattaagca aatcgatttc     1320

aaacttttcc aaaatttctc caatctggaa attatttact tgtcagaaaa cagaatatca     1380

ccgttggtaa aagatacccg gcagagttat gcaaatagtt cctcttttca acgtcatatc     1440

cggaaacgac gctcaacaga ttttgagttt gacccacatt cgaactttta tcatttcacc     1500

cgtcctttaa taaagccaca atgtgctgct tatggaaaag ccttagattt aagcctcaac     1560

agtattttct tcattgggcc aaaccaattt gaaaatcttc ctgacattgc ctgtttaaat     1620

ctgtctgcaa atagcaatgc tcaagtgtta agtggaactg aattttcagc cattcctcat     1680

gtcaaatatt tggatttgac aaacaataga ctagactttg ataatgctag tgctcttact     1740

gaattgtccg acttggaagt tctagatctc agctataatt cacactattt cagaatagca     1800

ggcgtaacac atcatctaga atttattcaa aatttcacaa atctaaaagt tttaaacttg     1860

agccacaaca acatttatac tttaacagat aagtataacc tggaaagcaa gtccctggta     1920

gaattagttt tcagtggcaa tcgccttgac attttgtgga atgatgatga caacaggtat     1980

atctccattt tcaaaggtct caagaatctg acacgtctgg atttatccct taataggctg     2040

aagcacatcc caaatgaagc attccttaat ttgccagcga gtctcactga actacatata     2100

aatgataata tgttaaagtt ttttaactgg acattactcc agcagtttcc tcgtctcgag     2160

ttgcttgact tacgtggaaa caaactactc tttttaactg atagcctatc tgactttaca     2220

tcttcccttc ggacactgct gctgagtcat aacaggattt cccacctacc ctctggcttt     2280

ctttctgaag tcagtagtct gaagcacctc gatttaagtt ccaatctgct aaaaacaatc     2340

aacaaatccg cacttgaaac taagaccacc accaaattat ctatgttgga actacacgga     2400

aacccctttg aatgcacctg tgacattgga gatttccgaa gatggatgga tgaacatctg     2460

aatgtcaaaa ttcccagact ggtagatgtc atttgtgcca gtcctgggga tcaaagaggg     2520

aagagtattg tgagtctgga gctaacaact tgtgtttcag atgtcactgc agtgatatta     2580

tttttcttca cgttctttat caccaccatg gttatgttgg ctgccctggc tcaccatttg     2640

ttttactggg atgtttggtt tatatataat gtgtgtttag ctaaggtaaa aggctacagg     2700

tctctttcca catcccaaac tttctatgat gcttacattt cttatgacac caaagatgcc     2760

tctgttactg actgggtgat aaatgagctg cgctaccacc ttgaagagag ccgagacaaa     2820

aacgttctcc tttgtctaga ggagagggat tgggacccgg gattggccat catcgacaac     2880

ctcatgcaga gcatcaacca aagcaagaaa acagtatttg ttttaaccaa aaaatatgca     2940

aaaagctgga actttaaaac agctttttac ttggctttgc agaggctaat ggatgagaac     3000

atggatgtga ttatatttat cctgctggag ccagtgttac agcattctca gtatttgagg     3060

ctacggcagc ggatctgtaa gagctccatc ctccagtggc ctgacaaccc gaaggcagaa     3120

ggcttgtttt ggcaaactct gagaaatgtg gtcttgactg aaaatgattc acggtataac     3180

aatatgtatg tcgattccat taagcaatac taactgacgt taagtcatga tttcgcgcca     3240

taataaagat gcaaaggaat gacatttctg tattagttat ctattgctat gtaacaaatt     3300

atcccaaaac ttagtggttt aaaacaacac atttgctggc ccacagtttt tgagggtcag     3360

gagtccaggc ccagcataac tgggtcctct gctcagggtg tctcagaggc tgcaatgtag     3420

gtgttcacca gagacatagg catcactggg gtcacactca tgtggttgtt ttctggattc     3480

aattcctcct gggctattgg ccaaaggcta tactcatgta agccatgcga gcctctccca     3540

caaggcagct tgcttcatca gagctagcaa aaaagagagg ttgctagcaa gatgaagtca     3600

caatcttttg taatcgaatc aaaaaagtga tatctcatca ctttggccat attctatttg     3660

ttagaagtaa accacaggtc ccaccagctc catgggagtg accacctcag tccagggaaa     3720

acagctgaag accaagatgg tgagctctga ttgcttcagt tggtcatcaa ctattttccc     3780

ttgactgctg tcctgggatg gcctgctatc ttgatgatag attgtgaata tcaggaggca     3840

gggatcactg tggaccatct tagcagttga cctaacacat cttcttttca atatctaaga     3900

acttttgcca ctgtgactaa tggtcctaat attaagctgt tgtttatatt tatcatatat     3960

ctatggctac atggttatat tatgctgtgg ttgcgttcgg ttttatttac agttgctttt     4020

acaaatattt gctgtaacat ttgacttcta aggtttagat gccatttaag aactgagatg     4080

gatagctttt aaagcatctt ttacttctta ccatttttta aaagtatgca gctaaattcg     4140

aagcttttgg tctatattgt taattgccat tgctgtaaat cttaaaatga atgaataaaa     4200

atgtttcatt ttacaa                                                     4216


<210>  152
<211>  4353
<212>  DNA
<213>  Homo sapiens

<400>  152
agtttctctt ctcggccacc tcctgcatag agggtaccat tctgcgctgc tgcaagttac       60

ggaatgaaaa attagaacaa cagaaacatg gttctcttga cacttcagtg ttagggaaca      120

tcagcaagac ccatcccagg agaccttgaa ggaagccttt gaaagggaga atgaaggagt      180

catctttgca aaatagctcc tgcagcctgg gaaaggagac taaaaaggaa aacatgttcc      240

ttcagtcgtc aatgctgacc tgcattttcc tgctaatatc tggttcctgt gagttatgcg      300

ccgaagaaaa tttttctaga agctatcctt gtgatgagaa aaagcaaaat gactcagtta      360

ttgcagagtg cagcaatcgt cgactacagg aagttcccca aacggtgggc aaatatgtga      420

cagaactaga cctgtctgat aatttcatca cacacataac gaatgaatca tttcaagggc      480

tgcaaaatct cactaaaata aatctaaacc acaaccccaa tgtacagcac cagaacggaa      540

atcccggtat acaatcaaat ggcttgaata tcacagacgg ggcattcctc aacctaaaaa      600

acctaaggga gttactgctt gaagacaacc agttacccca aataccctct ggtttgccag      660

agtctttgac agaacttagt ctaattcaaa acaatatata caacataact aaagagggca      720

tttcaagact tataaacttg aaaaatctct atttggcctg gaactgctat tttaacaaag      780

tttgcgagaa aactaacata gaagatggag tatttgaaac gctgacaaat ttggagttgc      840

tatcactatc tttcaattct ctttcacacg tgccacccaa actgccaagc tccctacgca      900

aactttttct gagcaacacc cagatcaaat acattagtga agaagatttc aagggattga      960

taaatttaac attactagat ttaagcggga actgtccgag gtgcttcaat gccccatttc     1020

catgcgtgcc ttgtgatggt ggtgcttcaa ttaatataga tcgttttgct tttcaaaact     1080

tgacccaact tcgataccta aacctctcta gcacttccct caggaagatt aatgctgcct     1140

ggtttaaaaa tatgcctcat ctgaaggtgc tggatcttga attcaactat ttagtgggag     1200

aaatagcctc tggggcattt ttaacgatgc tgccccgctt agaaatactt gacttgtctt     1260

ttaactatat aaaggggagt tatccacagc atattaatat ttccagaaac ttctctaaac     1320

ttttgtctct acgggcattg catttaagag gttatgtgtt ccaggaactc agagaagatg     1380

atttccagcc cctgatgcag cttccaaact tatcgactat caacttgggt attaatttta     1440

ttaagcaaat cgatttcaaa cttttccaaa atttctccaa tctggaaatt atttacttgt     1500

cagaaaacag aatatcaccg ttggtaaaag atacccggca gagttatgca aatagttcct     1560

cttttcaacg tcatatccgg aaacgacgct caacagattt tgagtttgac ccacattcga     1620

acttttatca tttcacccgt cctttaataa agccacaatg tgctgcttat ggaaaagcct     1680

tagatttaag cctcaacagt attttcttca ttgggccaaa ccaatttgaa aatcttcctg     1740

acattgcctg tttaaatctg tctgcaaata gcaatgctca agtgttaagt ggaactgaat     1800

tttcagccat tcctcatgtc aaatatttgg atttgacaaa caatagacta gactttgata     1860

atgctagtgc tcttactgaa ttgtccgact tggaagttct agatctcagc tataattcac     1920

actatttcag aatagcaggc gtaacacatc atctagaatt tattcaaaat ttcacaaatc     1980

taaaagtttt aaacttgagc cacaacaaca tttatacttt aacagataag tataacctgg     2040

aaagcaagtc cctggtagaa ttagttttca gtggcaatcg ccttgacatt ttgtggaatg     2100

atgatgacaa caggtatatc tccattttca aaggtctcaa gaatctgaca cgtctggatt     2160

tatcccttaa taggctgaag cacatcccaa atgaagcatt ccttaatttg ccagcgagtc     2220

tcactgaact acatataaat gataatatgt taaagttttt taactggaca ttactccagc     2280

agtttcctcg tctcgagttg cttgacttac gtggaaacaa actactcttt ttaactgata     2340

gcctatctga ctttacatct tcccttcgga cactgctgct gagtcataac aggatttccc     2400

acctaccctc tggctttctt tctgaagtca gtagtctgaa gcacctcgat ttaagttcca     2460

atctgctaaa aacaatcaac aaatccgcac ttgaaactaa gaccaccacc aaattatcta     2520

tgttggaact acacggaaac ccctttgaat gcacctgtga cattggagat ttccgaagat     2580

ggatggatga acatctgaat gtcaaaattc ccagactggt agatgtcatt tgtgccagtc     2640

ctggggatca aagagggaag agtattgtga gtctggagct aacaacttgt gtttcagatg     2700

tcactgcagt gatattattt ttcttcacgt tctttatcac caccatggtt atgttggctg     2760

ccctggctca ccatttgttt tactgggatg tttggtttat atataatgtg tgtttagcta     2820

aggtaaaagg ctacaggtct ctttccacat cccaaacttt ctatgatgct tacatttctt     2880

atgacaccaa agatgcctct gttactgact gggtgataaa tgagctgcgc taccaccttg     2940

aagagagccg agacaaaaac gttctccttt gtctagagga gagggattgg gacccgggat     3000

tggccatcat cgacaacctc atgcagagca tcaaccaaag caagaaaaca gtatttgttt     3060

taaccaaaaa atatgcaaaa agctggaact ttaaaacagc tttttacttg gctttgcaga     3120

ggctaatgga tgagaacatg gatgtgatta tatttatcct gctggagcca gtgttacagc     3180

attctcagta tttgaggcta cggcagcgga tctgtaagag ctccatcctc cagtggcctg     3240

acaacccgaa ggcagaaggc ttgttttggc aaactctgag aaatgtggtc ttgactgaaa     3300

atgattcacg gtataacaat atgtatgtcg attccattaa gcaatactaa ctgacgttaa     3360

gtcatgattt cgcgccataa taaagatgca aaggaatgac atttctgtat tagttatcta     3420

ttgctatgta acaaattatc ccaaaactta gtggtttaaa acaacacatt tgctggccca     3480

cagtttttga gggtcaggag tccaggccca gcataactgg gtcctctgct cagggtgtct     3540

cagaggctgc aatgtaggtg ttcaccagag acataggcat cactggggtc acactcatgt     3600

ggttgttttc tggattcaat tcctcctggg ctattggcca aaggctatac tcatgtaagc     3660

catgcgagcc tctcccacaa ggcagcttgc ttcatcagag ctagcaaaaa agagaggttg     3720

ctagcaagat gaagtcacaa tcttttgtaa tcgaatcaaa aaagtgatat ctcatcactt     3780

tggccatatt ctatttgtta gaagtaaacc acaggtccca ccagctccat gggagtgacc     3840

acctcagtcc agggaaaaca gctgaagacc aagatggtga gctctgattg cttcagttgg     3900

tcatcaacta ttttcccttg actgctgtcc tgggatggcc tgctatcttg atgatagatt     3960

gtgaatatca ggaggcaggg atcactgtgg accatcttag cagttgacct aacacatctt     4020

cttttcaata tctaagaact tttgccactg tgactaatgg tcctaatatt aagctgttgt     4080

ttatatttat catatatcta tggctacatg gttatattat gctgtggttg cgttcggttt     4140

tatttacagt tgcttttaca aatatttgct gtaacatttg acttctaagg tttagatgcc     4200

atttaagaac tgagatggat agcttttaaa gcatctttta cttcttacca ttttttaaaa     4260

gtatgcagct aaattcgaag cttttggtct atattgttaa ttgccattgc tgtaaatctt     4320

aaaatgaatg aataaaaatg tttcatttta caa                                  4353


<210>  153
<211>  1041
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Glu Glu Asn Phe Ser Arg 
            20                  25                  30          


Ser Tyr Pro Cys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile Ala Glu 
        35                  40                  45              


Cys Ser Asn Arg Arg Leu Gln Glu Val Pro Gln Thr Val Gly Lys Tyr 
    50                  55                  60                  


Val Thr Glu Leu Asp Leu Ser Asp Asn Phe Ile Thr His Ile Thr Asn 
65                  70                  75                  80  


Glu Ser Phe Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu Asn His 
                85                  90                  95      


Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln Ser Asn 
            100                 105                 110         


Gly Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn Leu Arg 
        115                 120                 125             


Glu Leu Leu Leu Glu Asp Asn Gln Leu Pro Gln Ile Pro Ser Gly Leu 
    130                 135                 140                 


Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile Tyr Asn 
145                 150                 155                 160 


Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr 
                165                 170                 175     


Leu Ala Trp Asn Cys Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile 
            180                 185                 190         


Glu Asp Gly Val Phe Glu Thr Leu Thr Asn Leu Glu Leu Leu Ser Leu 
        195                 200                 205             


Ser Phe Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu 
    210                 215                 220                 


Arg Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Ile Ser Glu Glu 
225                 230                 235                 240 


Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser Gly Asn 
                245                 250                 255     


Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys Asp Gly 
            260                 265                 270         


Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu Thr Gln 
        275                 280                 285             


Leu Arg Tyr Leu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile Asn Ala 
    290                 295                 300                 


Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu Glu Phe 
305                 310                 315                 320 


Asn Tyr Leu Val Gly Glu Ile Ala Ser Gly Ala Phe Leu Thr Met Leu 
                325                 330                 335     


Pro Arg Leu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Ile Lys Gly Ser 
            340                 345                 350         


Tyr Pro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu Leu Ser 
        355                 360                 365             


Leu Arg Ala Leu His Leu Arg Gly Tyr Val Phe Gln Glu Leu Arg Glu 
    370                 375                 380                 


Asp Asp Phe Gln Pro Leu Met Gln Leu Pro Asn Leu Ser Thr Ile Asn 
385                 390                 395                 400 


Leu Gly Ile Asn Phe Ile Lys Gln Ile Asp Phe Lys Leu Phe Gln Asn 
                405                 410                 415     


Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro 
            420                 425                 430         


Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln 
        435                 440                 445             


Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His 
    450                 455                 460                 


Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Cys Ala 
465                 470                 475                 480 


Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe Phe Ile 
                485                 490                 495     


Gly Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu Asn Leu 
            500                 505                 510         


Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe Ser Ala 
        515                 520                 525             


Ile Pro His Val Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu Asp Phe 
    530                 535                 540                 


Asp Asn Ala Ser Ala Leu Thr Glu Leu Ser Asp Leu Glu Val Leu Asp 
545                 550                 555                 560 


Leu Ser Tyr Asn Ser His Tyr Phe Arg Ile Ala Gly Val Thr His His 
                565                 570                 575     


Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn Leu Ser 
            580                 585                 590         


His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu Ser Lys 
        595                 600                 605             


Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile Leu Trp 
    610                 615                 620                 


Asn Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly Leu Lys Asn 
625                 630                 635                 640 


Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu Lys His Ile Pro Asn 
                645                 650                 655     


Glu Ala Phe Leu Asn Leu Pro Ala Ser Leu Thr Glu Leu His Ile Asn 
            660                 665                 670         


Asp Asn Met Leu Lys Phe Phe Asn Trp Thr Leu Leu Gln Gln Phe Pro 
        675                 680                 685             


Arg Leu Glu Leu Leu Asp Leu Arg Gly Asn Lys Leu Leu Phe Leu Thr 
    690                 695                 700                 


Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu Leu Ser 
705                 710                 715                 720 


His Asn Arg Ile Ser His Leu Pro Ser Gly Phe Leu Ser Glu Val Ser 
                725                 730                 735     


Ser Leu Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr Ile Asn 
            740                 745                 750         


Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser Met Leu Glu 
        755                 760                 765             


Leu His Gly Asn Pro Phe Glu Cys Thr Cys Asp Ile Gly Asp Phe Arg 
    770                 775                 780                 


Arg Trp Met Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu Val Asp 
785                 790                 795                 800 


Val Ile Cys Ala Ser Pro Gly Asp Gln Arg Gly Lys Ser Ile Val Ser 
                805                 810                 815     


Leu Glu Leu Thr Thr Cys Val Ser Asp Val Thr Ala Val Ile Leu Phe 
            820                 825                 830         


Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met Leu Ala Ala Leu Ala 
        835                 840                 845             


His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu 
    850                 855                 860                 


Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr 
865                 870                 875                 880 


Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp 
                885                 890                 895     


Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn 
            900                 905                 910         


Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile 
        915                 920                 925             


Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe 
    930                 935                 940                 


Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe 
945                 950                 955                 960 


Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile 
                965                 970                 975     


Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu 
            980                 985                 990         


Arg Gln Arg Ile Cys Lys Ser Ser  Ile Leu Gln Trp Pro  Asp Asn Pro 
        995                 1000                 1005             


Lys Ala  Glu Gly Leu Phe Trp  Gln Thr Leu Arg Asn  Val Val Leu 
    1010                 1015                 1020             


Thr Glu  Asn Asp Ser Arg Tyr  Asn Asn Met Tyr Val  Asp Ser Ile 
    1025                 1030                 1035             


Lys Gln  Tyr 
    1040     


<210>  154
<211>  1059
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Lys Glu Ser Ser Leu Gln Asn Ser Ser Cys Ser Leu Gly Lys Glu 
1               5                   10                  15      


Thr Lys Lys Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile 
            20                  25                  30          


Phe Leu Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Glu Glu Asn Phe 
        35                  40                  45              


Ser Arg Ser Tyr Pro Cys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile 
    50                  55                  60                  


Ala Glu Cys Ser Asn Arg Arg Leu Gln Glu Val Pro Gln Thr Val Gly 
65                  70                  75                  80  


Lys Tyr Val Thr Glu Leu Asp Leu Ser Asp Asn Phe Ile Thr His Ile 
                85                  90                  95      


Thr Asn Glu Ser Phe Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu 
            100                 105                 110         


Asn His Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln 
        115                 120                 125             


Ser Asn Gly Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn 
    130                 135                 140                 


Leu Arg Glu Leu Leu Leu Glu Asp Asn Gln Leu Pro Gln Ile Pro Ser 
145                 150                 155                 160 


Gly Leu Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile 
                165                 170                 175     


Tyr Asn Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn 
            180                 185                 190         


Leu Tyr Leu Ala Trp Asn Cys Tyr Phe Asn Lys Val Cys Glu Lys Thr 
        195                 200                 205             


Asn Ile Glu Asp Gly Val Phe Glu Thr Leu Thr Asn Leu Glu Leu Leu 
    210                 215                 220                 


Ser Leu Ser Phe Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser 
225                 230                 235                 240 


Ser Leu Arg Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Ile Ser 
                245                 250                 255     


Glu Glu Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser 
            260                 265                 270         


Gly Asn Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys 
        275                 280                 285             


Asp Gly Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu 
    290                 295                 300                 


Thr Gln Leu Arg Tyr Leu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile 
305                 310                 315                 320 


Asn Ala Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu 
                325                 330                 335     


Glu Phe Asn Tyr Leu Val Gly Glu Ile Ala Ser Gly Ala Phe Leu Thr 
            340                 345                 350         


Met Leu Pro Arg Leu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Ile Lys 
        355                 360                 365             


Gly Ser Tyr Pro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu 
    370                 375                 380                 


Leu Ser Leu Arg Ala Leu His Leu Arg Gly Tyr Val Phe Gln Glu Leu 
385                 390                 395                 400 


Arg Glu Asp Asp Phe Gln Pro Leu Met Gln Leu Pro Asn Leu Ser Thr 
                405                 410                 415     


Ile Asn Leu Gly Ile Asn Phe Ile Lys Gln Ile Asp Phe Lys Leu Phe 
            420                 425                 430         


Gln Asn Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile 
        435                 440                 445             


Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser 
    450                 455                 460                 


Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp 
465                 470                 475                 480 


Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln 
                485                 490                 495     


Cys Ala Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe 
            500                 505                 510         


Phe Ile Gly Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu 
        515                 520                 525             


Asn Leu Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe 
    530                 535                 540                 


Ser Ala Ile Pro His Val Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu 
545                 550                 555                 560 


Asp Phe Asp Asn Ala Ser Ala Leu Thr Glu Leu Ser Asp Leu Glu Val 
                565                 570                 575     


Leu Asp Leu Ser Tyr Asn Ser His Tyr Phe Arg Ile Ala Gly Val Thr 
            580                 585                 590         


His His Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn 
        595                 600                 605             


Leu Ser His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu 
    610                 615                 620                 


Ser Lys Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile 
625                 630                 635                 640 


Leu Trp Asn Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly Leu 
                645                 650                 655     


Lys Asn Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu Lys His Ile 
            660                 665                 670         


Pro Asn Glu Ala Phe Leu Asn Leu Pro Ala Ser Leu Thr Glu Leu His 
        675                 680                 685             


Ile Asn Asp Asn Met Leu Lys Phe Phe Asn Trp Thr Leu Leu Gln Gln 
    690                 695                 700                 


Phe Pro Arg Leu Glu Leu Leu Asp Leu Arg Gly Asn Lys Leu Leu Phe 
705                 710                 715                 720 


Leu Thr Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu 
                725                 730                 735     


Leu Ser His Asn Arg Ile Ser His Leu Pro Ser Gly Phe Leu Ser Glu 
            740                 745                 750         


Val Ser Ser Leu Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr 
        755                 760                 765             


Ile Asn Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser Met 
    770                 775                 780                 


Leu Glu Leu His Gly Asn Pro Phe Glu Cys Thr Cys Asp Ile Gly Asp 
785                 790                 795                 800 


Phe Arg Arg Trp Met Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu 
                805                 810                 815     


Val Asp Val Ile Cys Ala Ser Pro Gly Asp Gln Arg Gly Lys Ser Ile 
            820                 825                 830         


Val Ser Leu Glu Leu Thr Thr Cys Val Ser Asp Val Thr Ala Val Ile 
        835                 840                 845             


Leu Phe Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met Leu Ala Ala 
    850                 855                 860                 


Leu Ala His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val 
865                 870                 875                 880 


Cys Leu Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr 
                885                 890                 895     


Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr 
            900                 905                 910         


Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp 
        915                 920                 925             


Lys Asn Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu 
    930                 935                 940                 


Ala Ile Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr 
945                 950                 955                 960 


Val Phe Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr 
                965                 970                 975     


Ala Phe Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val 
            980                 985                 990         


Ile Ile Phe Ile Leu Leu Glu Pro  Val Leu Gln His Ser  Gln Tyr Leu 
        995                 1000                 1005             


Arg Leu  Arg Gln Arg Ile Cys  Lys Ser Ser Ile Leu  Gln Trp Pro 
    1010                 1015                 1020             


Asp Asn  Pro Lys Ala Glu Gly  Leu Phe Trp Gln Thr  Leu Arg Asn 
    1025                 1030                 1035             


Val Val  Leu Thr Glu Asn Asp  Ser Arg Tyr Asn Asn  Met Tyr Val 
    1040                 1045                 1050             


Asp Ser  Ile Lys Gln Tyr 
    1055                 


<210>  155
<211>  5799
<212>  DNA
<213>  Homo sapiens

<400>  155
agtgccggct gccgatgacc gattcacgct cccggtactg gggccccctc tgcccagcca       60

cccctaccca gagcacccgg gctgcgcggc cccgccgagg gtgcgggctt tgttcgcatt      120

gtctgcgcgc acctgagcgc ggccttcctg gcacggcggc gtcgggggaa gagcgcacct      180

ggcgcgcgcc tccctcgtgg ccactcgcgg tccgtcccgg gcgagctggc ggggttttgg      240

gaggggtgcg gtcagcagtt atatcaacat gccccctttc ctgttgctgg aagccgtctg      300

tgttttcctg ttttccagag tgcccccatc tctccctctc caggaagtcc atgtaagcaa      360

agaaaccatc gggaagattt cagctgccag caaaatgatg tggtgctcgg ctgcagtgga      420

catcatgttt ctgttagatg ggtctaacag cgtcgggaaa gggagctttg aaaggtccaa      480

gcactttgcc atcacagtct gtgacggtct ggacatcagc cccgagaggg tcagagtggg      540

agcattccag ttcagttcca ctcctcatct ggaattcccc ttggattcat tttcaaccca      600

acaggaagtg aaggcaagaa tcaagaggat ggttttcaaa ggagggcgca cggagacgga      660

acttgctctg aaataccttc tgcacagagg gttgcctgga ggcagaaatg cttctgtgcc      720

ccagatcctc atcatcgtca ctgatgggaa gtcccagggg gatgtggcac tgccatccaa      780

gcagctgaag gaaaggggtg tcactgtgtt tgctgtgggg gtcaggtttc ccaggtggga      840

ggagctgcat gcactggcca gcgagcctag agggcagcac gtgctgttgg ctgagcaggt      900

ggaggatgcc accaacggcc tcttcagcac cctcagcagc tcggccatct gctccagcgc      960

cacgccagac tgcagggtcg aggctcaccc ctgtgagcac aggacgctgg agatggtccg     1020

ggagttcgct ggcaatgccc catgctggag aggatcgcgg cggacccttg cggtgctggc     1080

tgcacactgt cccttctaca gctggaagag agtgttccta acccaccctg ccacctgcta     1140

caggaccacc tgcccaggcc cctgtgactc gcagccctgc cagaatggag gcacatgtgt     1200

tccagaagga ctggacggct accagtgcct ctgcccgctg gcctttggag gggaggctaa     1260

ctgtgccctg aagctgagcc tggaatgcag ggtcgacctc ctcttcctgc tggacagctc     1320

tgcgggcacc actctggacg gcttcctgcg ggccaaagtc ttcgtgaagc ggtttgtgcg     1380

ggccgtgctg agcgaggact ctcgggcccg agtgggtgtg gccacataca gcagggagct     1440

gctggtggcg gtgcctgtgg gggagtacca ggatgtgcct gacctggtct ggagcctcga     1500

tggcattccc ttccgtggtg gccccaccct gacgggcagt gccttgcggc aggcggcaga     1560

gcgtggcttc gggagcgcca ccaggacagg ccaggaccgg ccacgtagag tggtggtttt     1620

gctcactgag tcacactccg aggatgaggt tgcgggccca gcgcgtcacg caagggcgcg     1680

agagctgctc ctgctgggtg taggcagtga ggccgtgcgg gcagagctgg aggagatcac     1740

aggcagccca aagcatgtga tggtctactc ggatcctcag gatctgttca accaaatccc     1800

tgagctgcag gggaagctgt gcagccggca gcggccaggg tgccggacac aagccctgga     1860

cctcgtcttc atgttggaca cctctgcctc agtagggccc gagaattttg ctcagatgca     1920

gagctttgtg agaagctgtg ccctccagtt tgaggtgaac cctgacgtga cacaggtcgg     1980

cctggtggtg tatggcagcc aggtgcagac tgccttcggg ctggacacca aacccacccg     2040

ggctgcgatg ctgcgggcca ttagccaggc cccctaccta ggtggggtgg gctcagccgg     2100

caccgccctg ctgcacatct atgacaaagt gatgaccgtc cagaggggtg cccggcctgg     2160

tgtccccaaa gctgtggtgg tgctcacagg cgggagaggc gcagaggatg cagccgttcc     2220

tgcccagaag ctgaggaaca atggcatctc tgtcttggtc gtgggcgtgg ggcctgtcct     2280

aagtgagggt ctgcggaggc ttgcaggtcc ccgggattcc ctgatccacg tggcagctta     2340

cgccgacctg cggtaccacc aggacgtgct cattgagtgg ctgtgtggag aagccaagca     2400

gccagtcaac ctctgcaaac ccagcccgtg catgaatgag ggcagctgcg tcctgcagaa     2460

tgggagctac cgctgcaagt gtcgggatgg ctgggagggc ccccactgcg agaaccgatt     2520

cttgagacgc ccctgaggca catggctccc gtgcaggagg gcagcagccg tacccctccc     2580

agcaactaca gagaaggcct gggcactgaa atggtgccta ccttctggaa tgtctgtgcc     2640

ccaggtcctt agaatgtctg cttcccgccg tggccaggac cactattctc actgagggag     2700

gaggatgtcc caactgcagc catgctgctt agagacaaga aagcagctga tgtcacccac     2760

aaacgatgtt gttgaaaagt tttgatgtgt aagtaaatac ccactttctg tacctgctgt     2820

gccttgttga ggctatgtca tctgccacct ttcccttgag gataaacaag gggtcctgaa     2880

gacttaaatt tagcggcctg acgttccttt gcacacaatc aatgctcgcc agaatgttgt     2940

tgacacagta atgcccagca gaggccttta ctagagcatc ctttggacgg cgaaggccac     3000

ggcctttcaa gatggaaagc agcagctttt ccacttcccc agagacattc tggatgcatt     3060

tgcattgagt ctgaaagggg gcttgaggga cgtttgtgac ttctggcgac tgccttttgt     3120

gtgtggaaga gacttggaaa ggtctcagac tgaaatgtga ccaattaacc agcttgtttg     3180

atgatggggg aggggctgag tgtgcaatgg gcccaggtct ggaggggcca cgtaaaatcg     3240

ttctgagtcg tgagcagtgt ccacctgaag ggtcttcctt tcaaaagagg ctgcggccag     3300

agactgtggc tcatgcctgt aatcccagca ctttggaggc tgaggcaggt ggatcacccg     3360

aggtcaggag tttgagacca gcctggccaa cgtggtgaaa gtttgtcttt actaaaaata     3420

caaaaggtag ccgggggtgg tggtggatgc ctataatccc agctactcgg gaggctgaga     3480

caggagaatg gcttgaacct gggaggcgga agttacagtg agccgagatc tcaccactgc     3540

actccagcct gggcaacaag agtaaaaatc tgtctcaaaa agaaaaaaat gtacttagga     3600

ggggttaatt gtggcgtgtt tatggaattc tttccttatt ctccttttag tggggcaaag     3660

agaagtaaga ttcttaaact caaaaatata ggataaagaa acttacagag attttgcttt     3720

ttaaagcatt gatcttacgc tgtctaggtt ttaattttgt tttgctttgc ttttctacac     3780

agtttttaaa gaaatatttc aagaaatgtt ggttatttat taaacaggga tatttgtacc     3840

tatgtggcaa agaggcatat ttggaatatt ctctggcaaa ctagatactt acttccctat     3900

cgctgcagta tttaggaatt acttcttctc cttggttgtg ttgtttagag ttggattttc     3960

tgtagaaatc tttctagagc tctgatgtga ctccagacac tttatcgttt ttcttttttt     4020

tgagacggag ttttgctctt gttgcccagg ctagagtgca gtggtacaat cttggctcac     4080

tgcaaccttt gcctcccagg ttgaagtgat tctcatgcct cagcctcttg agtagctggg     4140

attagaggca ggtgccacca tgcctagcta atttttgtat ttttagttag agacagggtt     4200

tcaccatgtt ggccaggcta gtctcgaact tctgacctca ggtgatcccc ctgccttggc     4260

ctcccaaagt tctgggatta caggggtgaa ccactgtgcc tggcccattt ttctttataa     4320

atattgtaac ataatgtttt atagacaaac attcaagggt actttggctt taagaacttc     4380

aggatttctg gtgctagaaa agcgcttgaa gcagtatcac caagatttta gatattaaaa     4440

agtctggtgt accagacatt gagtcataat catctatatt caagggatac tttcattgat     4500

aactttgtta ttatgctgcc cttcacagaa gacaacgtcc ggggcaggat cacatgctcc     4560

ctagcagatg ctgatcagtg atgtcataga aattacatga atgcattgtc tttaaatagc     4620

agtttaacca tgttataatg taggcttttt gtcttgttcc gggctggtat ttgggtgccc     4680

tgattgaatt acttggattt aaacagcaaa ctgtgggctc tcgacttaca tagtaagggc     4740

ctttactgtt tctttgtagg aaatgggttt ctcgcctttg aaacattttt tccccttttg     4800

tagtgacagt gccactaaat agttcagctt ttgtcagtcc cccaggaaag tgctatccta     4860

tggcctaact agccaagcct tttttctttc atttaaaaga aattagcttt aatttttacc     4920

tttaattact tattcaaata agacagaaat atattttcct tgcaataatt aaaacattgc     4980

atataggcca taaatttcct tattttctct gaacgatcct gattccagtc atcttgttga     5040

ataccctagt tctaataatt gactcttgct tttctagaga aatatttcca aatgatgcta     5100

gttttgtctc ttcctttcaa agttgtatac cacttctttt tcttgtcatt ttgcattgcc     5160

tgggacctcc agaataatgt ttcatgaagt agcatgtatc catatctggt tcttgacttt     5220

ttcatcataa taattgtttt ctatgggtta cttatcagtt taagaatgct taattcctag     5280

atgaactaag agtgtttatt acatgttgag atttatggta tgctttttct tcctcaagat     5340

aatgcatttt ttgtattatc tgttaatgtg ataggttatc catttgtgta ttttcaatca     5400

ttgaacaacc cttgattttt ttggataaac tctatttggt cattatgcat cattctataa     5460

accctgctga atttttcatt tgccaacatc ttatttcaga ttcttttaat ctgtgtccaa     5520

caatgagatt tgttttcttt tgcaatttgt tttgaatttt tggtatcaga gctatactaa     5580

ccttataatg gaaaatacat atttctcaaa cttttacact gatatattca tagtattttt     5640

ttataatttg aaaaatcttg tcagtatctg tattaaggcc tccatttcag ttctgctatt     5700

tcatattgcc ttaggttgtc tatttgtctc tttaatgaac ccgattttga ttttgtcatt     5760

tttaaaataa acacatttat gctataaact tccttaatt                            5799


<210>  156
<211>  755
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Pro Pro Phe Leu Leu Leu Glu Ala Val Cys Val Phe Leu Phe Ser 
1               5                   10                  15      


Arg Val Pro Pro Ser Leu Pro Leu Gln Glu Val His Val Ser Lys Glu 
            20                  25                  30          


Thr Ile Gly Lys Ile Ser Ala Ala Ser Lys Met Met Trp Cys Ser Ala 
        35                  40                  45              


Ala Val Asp Ile Met Phe Leu Leu Asp Gly Ser Asn Ser Val Gly Lys 
    50                  55                  60                  


Gly Ser Phe Glu Arg Ser Lys His Phe Ala Ile Thr Val Cys Asp Gly 
65                  70                  75                  80  


Leu Asp Ile Ser Pro Glu Arg Val Arg Val Gly Ala Phe Gln Phe Ser 
                85                  90                  95      


Ser Thr Pro His Leu Glu Phe Pro Leu Asp Ser Phe Ser Thr Gln Gln 
            100                 105                 110         


Glu Val Lys Ala Arg Ile Lys Arg Met Val Phe Lys Gly Gly Arg Thr 
        115                 120                 125             


Glu Thr Glu Leu Ala Leu Lys Tyr Leu Leu His Arg Gly Leu Pro Gly 
    130                 135                 140                 


Gly Arg Asn Ala Ser Val Pro Gln Ile Leu Ile Ile Val Thr Asp Gly 
145                 150                 155                 160 


Lys Ser Gln Gly Asp Val Ala Leu Pro Ser Lys Gln Leu Lys Glu Arg 
                165                 170                 175     


Gly Val Thr Val Phe Ala Val Gly Val Arg Phe Pro Arg Trp Glu Glu 
            180                 185                 190         


Leu His Ala Leu Ala Ser Glu Pro Arg Gly Gln His Val Leu Leu Ala 
        195                 200                 205             


Glu Gln Val Glu Asp Ala Thr Asn Gly Leu Phe Ser Thr Leu Ser Ser 
    210                 215                 220                 


Ser Ala Ile Cys Ser Ser Ala Thr Pro Asp Cys Arg Val Glu Ala His 
225                 230                 235                 240 


Pro Cys Glu His Arg Thr Leu Glu Met Val Arg Glu Phe Ala Gly Asn 
                245                 250                 255     


Ala Pro Cys Trp Arg Gly Ser Arg Arg Thr Leu Ala Val Leu Ala Ala 
            260                 265                 270         


His Cys Pro Phe Tyr Ser Trp Lys Arg Val Phe Leu Thr His Pro Ala 
        275                 280                 285             


Thr Cys Tyr Arg Thr Thr Cys Pro Gly Pro Cys Asp Ser Gln Pro Cys 
    290                 295                 300                 


Gln Asn Gly Gly Thr Cys Val Pro Glu Gly Leu Asp Gly Tyr Gln Cys 
305                 310                 315                 320 


Leu Cys Pro Leu Ala Phe Gly Gly Glu Ala Asn Cys Ala Leu Lys Leu 
                325                 330                 335     


Ser Leu Glu Cys Arg Val Asp Leu Leu Phe Leu Leu Asp Ser Ser Ala 
            340                 345                 350         


Gly Thr Thr Leu Asp Gly Phe Leu Arg Ala Lys Val Phe Val Lys Arg 
        355                 360                 365             


Phe Val Arg Ala Val Leu Ser Glu Asp Ser Arg Ala Arg Val Gly Val 
    370                 375                 380                 


Ala Thr Tyr Ser Arg Glu Leu Leu Val Ala Val Pro Val Gly Glu Tyr 
385                 390                 395                 400 


Gln Asp Val Pro Asp Leu Val Trp Ser Leu Asp Gly Ile Pro Phe Arg 
                405                 410                 415     


Gly Gly Pro Thr Leu Thr Gly Ser Ala Leu Arg Gln Ala Ala Glu Arg 
            420                 425                 430         


Gly Phe Gly Ser Ala Thr Arg Thr Gly Gln Asp Arg Pro Arg Arg Val 
        435                 440                 445             


Val Val Leu Leu Thr Glu Ser His Ser Glu Asp Glu Val Ala Gly Pro 
    450                 455                 460                 


Ala Arg His Ala Arg Ala Arg Glu Leu Leu Leu Leu Gly Val Gly Ser 
465                 470                 475                 480 


Glu Ala Val Arg Ala Glu Leu Glu Glu Ile Thr Gly Ser Pro Lys His 
                485                 490                 495     


Val Met Val Tyr Ser Asp Pro Gln Asp Leu Phe Asn Gln Ile Pro Glu 
            500                 505                 510         


Leu Gln Gly Lys Leu Cys Ser Arg Gln Arg Pro Gly Cys Arg Thr Gln 
        515                 520                 525             


Ala Leu Asp Leu Val Phe Met Leu Asp Thr Ser Ala Ser Val Gly Pro 
    530                 535                 540                 


Glu Asn Phe Ala Gln Met Gln Ser Phe Val Arg Ser Cys Ala Leu Gln 
545                 550                 555                 560 


Phe Glu Val Asn Pro Asp Val Thr Gln Val Gly Leu Val Val Tyr Gly 
                565                 570                 575     


Ser Gln Val Gln Thr Ala Phe Gly Leu Asp Thr Lys Pro Thr Arg Ala 
            580                 585                 590         


Ala Met Leu Arg Ala Ile Ser Gln Ala Pro Tyr Leu Gly Gly Val Gly 
        595                 600                 605             


Ser Ala Gly Thr Ala Leu Leu His Ile Tyr Asp Lys Val Met Thr Val 
    610                 615                 620                 


Gln Arg Gly Ala Arg Pro Gly Val Pro Lys Ala Val Val Val Leu Thr 
625                 630                 635                 640 


Gly Gly Arg Gly Ala Glu Asp Ala Ala Val Pro Ala Gln Lys Leu Arg 
                645                 650                 655     


Asn Asn Gly Ile Ser Val Leu Val Val Gly Val Gly Pro Val Leu Ser 
            660                 665                 670         


Glu Gly Leu Arg Arg Leu Ala Gly Pro Arg Asp Ser Leu Ile His Val 
        675                 680                 685             


Ala Ala Tyr Ala Asp Leu Arg Tyr His Gln Asp Val Leu Ile Glu Trp 
    690                 695                 700                 


Leu Cys Gly Glu Ala Lys Gln Pro Val Asn Leu Cys Lys Pro Ser Pro 
705                 710                 715                 720 


Cys Met Asn Glu Gly Ser Cys Val Leu Gln Asn Gly Ser Tyr Arg Cys 
                725                 730                 735     


Lys Cys Arg Asp Gly Trp Glu Gly Pro His Cys Glu Asn Arg Phe Leu 
            740                 745                 750         


Arg Arg Pro 
        755 


<210>  157
<211>  1860
<212>  DNA
<213>  Homo sapiens

<400>  157
atgccagacc ccgcggcgca cctgcccttc ttctacggca gcatctcgcg tgccgaggcc       60

gaggagcacc tgaagctggc gggcatggcg gacgggctct tcctgctgcg ccagtgcctg      120

cgctcgctgg gcggctatgt gctgtcgctc gtgcacgatg tgcgcttcca ccactttccc      180

atcgagcgcc agctcaacgg cacctacgcc attgccggcg gcaaagcgca ctgtggaccg      240

gcagagctct gcgagttcta ctcgcgcgac cccgacgggc tgccctgcaa cctgcgcaag      300

ccgtgcaacc ggccgtcggg cctcgagccg cagccggggg tcttcgactg cctgcgagac      360

gccatggtgc gtgactacgt gcgccagacg tggaagctgg agggcgaggc cctggagcag      420

gccatcatca gccaggcccc gcaggtggag aagctcattg ctacgacggc ccacgagcgg      480

atgccctggt accacagcag cctgacgcgt gaggaggccg agcgcaaact ttactctggg      540

gcgcagaccg acggcaagtt cctgctgagg ccgcggaagg agcagggcac atacgccctg      600

tccctcatct atgggaagac ggtgtaccac tacctcatca gccaagacaa ggcgggcaag      660

tactgcattc ccgagggcac caagtttgac acgctctggc agctggtgga gtatctgaag      720

ctgaaggcgg acgggctcat ctactgcctg aaggaggcct gccccaacag cagtgccagc      780

aacgcctcag gggctgctgc tcccacactc ccagcccacc catccacgtt gactcatcct      840

cagagacgaa tcgacaccct caactcagat ggatacaccc ctgagccagc acgcataacg      900

tccccagaca aaccgcggcc gatgcccatg gacacgagcg tgtatgagag cccctacagc      960

gacccagagg agctcaagga caagaagctc ttcctgaagc gcgataacct cctcatagct     1020

gacattgaac ttggctgcgg caactttggc tcagtgcgcc agggcgtgta ccgcatgcgc     1080

aagaagcaga tcgacgtggc catcaaggtg ctgaagcagg gcacggagaa ggcagacacg     1140

gaagagatga tgcgcgaggc gcagatcatg caccagctgg acaaccccta catcgtgcgg     1200

ctcattggcg tctgccaggc cgaggccctc atgctggtca tggagatggc tgggggcggg     1260

ccgctgcaca agttcctggt cggcaagagg gaggagatcc ctgtgagcaa tgtggccgag     1320

ctgctgcacc aggtgtccat ggggatgaag tacctggagg agaagaactt tgtgcaccgt     1380

gacctggcgg cccgcaacgt cctgctggtt aaccggcact acgccaagat cagcgacttt     1440

ggcctctcca aagcactggg tgccgacgac agctactaca ctgcccgctc agcagggaag     1500

tggccgctca agtggtacgc acccgaatgc atcaacttcc gcaagttctc cagccgcagc     1560

gatgtctgga gctatggggt caccatgtgg gaggccttgt cctacggcca gaagccctac     1620

aagaagatga aagggccgga ggtcatggcc ttcatcgagc agggcaagcg gatggagtgc     1680

ccaccagagt gtccacccga actgtacgca ctcatgagtg actgctggat ctacaagtgg     1740

gaggatcgcc ccgacttcct gaccgtggag cagcgcatgc gagcctgtta ctacagcctg     1800

gccagcaagg tggaagggcc cccaggcagc acacagaagg ctgaggctgc ctgtgcctga     1860


<210>  158
<211>  1468
<212>  DNA
<213>  Homo sapiens

<400>  158
tgcatgctcc agggacggca cccttgtctg gggcaggtgc ttgtgggggc tgaggctgcc       60

ttgctcccca cacccctgcc cctgacctgg gagtgtaccg ctgtgtgtgc ccagcacgca      120

taacgtcccc agacaaaccg cggccgatgc ccatggacac gagcgtgtat gagagcccct      180

acagcgaccc agaggagctc aaggacaaga agctcttcct gaagcgcgat aacctcctca      240

tagctgacat tgaacttggc tgcggcaact ttggctcagt gcgccagggc gtgtaccgca      300

tgcgcaagaa gcagatcgac gtggccatca aggtgctgaa gcagggcacg gagaaggcag      360

acacggaaga gatgatgcgc gaggcgcaga tcatgcacca gctggacaac ccctacatcg      420

tgcggctcat tggcgtctgc caggccgagg ccctcatgct ggtcatggag atggctgggg      480

gcgggccgct gcacaagttc ctggtcggca agagggagga gatccctgtg agcaatgtgg      540

ccgagctgct gcaccaggtg tccatgggga tgaagtacct ggaggagaag aactttgtgc      600

accgtgacct ggcggcccgc aacgtcctgc tggttaaccg gcactacgcc aagatcagcg      660

actttggcct ctccaaagca ctgggtgccg acgacagcta ctacactgcc cgctcagcag      720

ggaagtggcc gctcaagtgg tacgcacccg aatgcatcaa cttccgcaag ttctccagcc      780

gcagcgatgt ctggagctat ggggtcacca tgtgggaggc cttgtcctac ggccagaagc      840

cctacaagaa gatgaaaggg ccggaggtca tggccttcat cgagcagggc aagcggatgg      900

agtgcccacc agagtgtcca cccgaactgt acgcactcat gagtgactgc tggatctaca      960

agtgggagga tcgccccgac ttcctgaccg tggagcagcg catgcgagcc tgttactaca     1020

gcctggccag caaggtggaa gggcccccag gcagcacaca gaaggctgag gctgcctgtg     1080

cctgagctcc cgctgcccag gggagccctc cacgccggct cttccccacc ctcagcccca     1140

ccccaggtcc tgcagtctgg ctgagccctg cttggttgtc tccacacaca gctgggctgt     1200

ggtagggggt gtctcaggcc acaccggcct tgcattgcct gcctggcccc ctgtcctctc     1260

tggctgggga gcagggaggt ccgggagggt gcggctgtgc agcctgtcct gggctggtgg     1320

ctcccggagg gccctgagct gagggcattg cttacacgga tgccttcccc tgggccctga     1380

cattggagcc tgggcatcct caggtggtca ggcgtagatc accagaataa acccagcttc     1440

cctcttgaaa aaaaaaaaaa aaaaaaaa                                        1468


<210>  159
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  160
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp Pro Glu 
1               5                   10                  15      


Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu Leu Ile 
            20                  25                  30          


Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg Gln Gly 
        35                  40                  45              


Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys Val Leu 
    50                  55                  60                  


Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg Glu Ala 
65                  70                  75                  80  


Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu Ile Gly 
                85                  90                  95      


Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala Gly Gly 
            100                 105                 110         


Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile Pro Val 
        115                 120                 125             


Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met Lys Tyr 
    130                 135                 140                 


Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
145                 150                 155                 160 


Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser 
                165                 170                 175     


Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser Ala Gly 
            180                 185                 190         


Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe Arg Lys 
        195                 200                 205             


Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met Trp Glu 
    210                 215                 220                 


Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly Pro Glu 
225                 230                 235                 240 


Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro Pro Glu 
                245                 250                 255     


Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile Tyr Lys 
            260                 265                 270         


Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met Arg Ala 
        275                 280                 285             


Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro Gly Ser Thr 
    290                 295                 300                 


Gln Lys Ala Glu Ala Ala Cys Ala 
305                 310         


<210>  161
<211>  2142
<212>  DNA
<213>  Homo sapiens

<400>  161
agagctgcaa gaagcaccag gctcggccac ttcagaagcc ccagcctcga cctagcccac       60

cctctcaggg ccacagtgca gaagcctgca cacctgccaa gtctctccga ctccttgcag      120

ctgctgtcag catggcccag gctcctgctg acccgggcag agaaggccac cttgaacaaa      180

gaatcctgca ggtgctgaca gaggctggct ccccggtgaa acttgcccag ctggtgaagg      240

aatgccaagc acccaagagg gagctcaacc aagtcctcta ccgaatgaaa aaggagttga      300

aagtctccct cacatcccct gccacctggt gcttgggcgg gactgatcct gaaggcgagg      360

gtcctgcaga gctggccttg tccagccctg ccgagaggcc ccagcaacat gcagctacaa      420

ttccagagac ccctggccct cagttcagcc aacaacggga ggaagacatc tacaggtttc      480

tcaaagacaa tggtccccag agggccctgg tcatcgccca agcactggga atgaggacag      540

caaaagatgt gaaccgagac ttgtacagga tgaagagcag gcaccttctg gacatggatg      600

agcagtccaa agcatggacg atttaccgcc cagaagattc tggaagaaga gcaaagtcag      660

cctcaattat ttaccagcac aatccaatca acatgatctg ccagaatgga cccaacagct      720

ggatttccat tgcaaactcc gaagccatcc agattggaca cgggaacatc attacaagac      780

agacagtctc cagggaggac ggttccgccg gtccacgcca cctcccttca atggcaccag      840

gtgattcctc aacttggggg accctagttg atccctgggg gccccaggac atccacatgg      900

agcagtccat actgagacgg gtgcagctgg gacacagcaa tgagatgagg ctccacggcg      960

tcccgtccga gggccctgcc cacatccccc ctggcagccc cccagtctct gccactgctg     1020

ccggcccaga agcttcgttt gaagcaagaa ttcccagtcc aggaactcac cctgaggggg     1080

aagccgccca gagaatccac atgaaatcgt gctttctcga ggacgccacc atcggcaaca     1140

gcaacaaaat gtctatcagc ccaggggtgg ctggcccagg aggagtcgca gggtctggag     1200

agggggagcc aggggaggac gcaggtcgtc gtcccgcaga cacacaatcc agaagtcact     1260

ttcctcgaga cattggtcag cccatcactc ccagccactc gaagctcacc cccaagctgg     1320

aaactatgac tcttggaaac aggagtcaca aagctgcaga aggcagccac tatgtggatg     1380

aagcctcaca cgaggggagc tggtggggag gtgggattta gtgcacagcc tcacgtgggg     1440

cttggacaca ggctgggggt gggcgcatgc tagggagact agcctgctgc tctctgcatt     1500

ccttagcgtc ttgtttgacc tgcttgcttc cagacataac ctgcatgaat cagttttggg     1560

ggaatggacc tggcatgggg atgggttcag gccaggtctt ttgatggcca ggagtagatg     1620

acagggagtt gccttgggga acctttggtg tgccaagagg aggtgggtag atgggagtgg     1680

ggctcggtcc cccaggccca ggggactctc tccactcttt cctgggctcg gggcatctgc     1740

ctggagttac cttccatcat ggctacctgc tgtggtttga atgtttgagt cccaacaaaa     1800

ttcatatcaa aacataatcc caactgggtg cagtggctca cgcctgtaat cccagcactt     1860

tgggaggccg aggcgggcgg atcaataggt caggaaatcc agaccgtcct ggctaacatg     1920

gtgaaacccc gtctctacta aaaaaaaaaa tacaaaaaat tagccgggcg ttgtggcggg     1980

cacctggagt cccagctact ccggaggctg agggaggaga atggtgtgaa cccgggaggt     2040

ggagcttcca gtgagccgag atcgcgccac tgcactccag gctgggcgac agagcgagac     2100

tccgtctcaa aaaaataaat acataaataa aaaataaacc aa                        2142


<210>  162
<211>  1917
<212>  DNA
<213>  Homo sapiens

<400>  162
agagctgcaa gaagcaccag gctcggccac ttcagaagcc ccagcctcga cctagcccac       60

cctctcaggg ccacagtgca gaagcctgca cacctgccaa gtctctccga ctccttgcag      120

ctgctgtcag catggcccag gctcctgctg acccgggcag agaagccgag aggccccagc      180

aacatgcagc tacaattcca gagacccctg gccctcagtt cagccaacaa cgggaggaag      240

acatctacag gtttctcaaa gacaatggtc cccagagggc cctggtcatc gcccaagcac      300

tgggaatgag gacagcaaaa gatgtgaacc gagacttgta caggatgaag agcaggcacc      360

ttctggacat ggatgagcag tccaaagcat ggacgattta ccgcccagaa gattctggaa      420

gaagagcaaa gtcagcctca attatttacc agcacaatcc aatcaacatg atctgccaga      480

atggacccaa cagctggatt tccattgcaa actccgaagc catccagatt ggacacggga      540

acatcattac aagacagaca gtctccaggg aggacggttc cgccggtcca cgccacctcc      600

cttcaatggc accaggtgat tcctcaactt gggggaccct agttgatccc tgggggcccc      660

aggacatcca catggagcag tccatactga gacgggtgca gctgggacac agcaatgaga      720

tgaggctcca cggcgtcccg tccgagggcc ctgcccacat cccccctggc agccccccag      780

tctctgccac tgctgccggc ccagaagctt cgtttgaagc aagaattccc agtccaggaa      840

ctcaccctga gggggaagcc gcccagagaa tccacatgaa atcgtgcttt ctcgaggacg      900

ccaccatcgg caacagcaac aaaatgtcta tcagcccagg ggtggctggc ccaggaggag      960

tcgcagggtc tggagagggg gagccagggg aggacgcagg tcgtcgtccc gcagacacac     1020

aatccagaag tcactttcct cgagacattg gtcagcccat cactcccagc cactcgaagc     1080

tcacccccaa gctggaaact atgactcttg gaaacaggag tcacaaagct gcagaaggca     1140

gccactatgt ggatgaagcc tcacacgagg ggagctggtg gggaggtggg atttagtgca     1200

cagcctcacg tggggcttgg acacaggctg ggggtgggcg catgctaggg agactagcct     1260

gctgctctct gcattcctta gcgtcttgtt tgacctgctt gcttccagac ataacctgca     1320

tgaatcagtt ttgggggaat ggacctggca tggggatggg ttcaggccag gtcttttgat     1380

ggccaggagt agatgacagg gagttgcctt ggggaacctt tggtgtgcca agaggaggtg     1440

ggtagatggg agtggggctc ggtcccccag gcccagggga ctctctccac tctttcctgg     1500

gctcggggca tctgcctgga gttaccttcc atcatggcta cctgctgtgg tttgaatgtt     1560

tgagtcccaa caaaattcat atcaaaacat aatcccaact gggtgcagtg gctcacgcct     1620

gtaatcccag cactttggga ggccgaggcg ggcggatcaa taggtcagga aatccagacc     1680

gtcctggcta acatggtgaa accccgtctc tactaaaaaa aaaaatacaa aaaattagcc     1740

gggcgttgtg gcgggcacct ggagtcccag ctactccgga ggctgaggga ggagaatggt     1800

gtgaacccgg gaggtggagc ttccagtgag ccgagatcgc gccactgcac tccaggctgg     1860

gcgacagagc gagactccgt ctcaaaaaaa taaatacata aataaaaaat aaaccaa        1917


<210>  163
<211>  1255
<212>  DNA
<213>  Homo sapiens

<400>  163
tttttttttc tttcaaaaga cgaacagaga agtttcattt tctttttctc ctgaaaccga       60

atctggccgg cctggctagg catctatttc cgggctgtaa gcagctgaca cctgcccagt      120

ggaagctggc atccctcccc ttgtgggttc agagctgcaa gaagcaccag gctcggccac      180

ttcagaagcc ccagcctcga cctagcccac cctctcaggg ccacagtgca gaagcctgca      240

cacctgccaa gtctctccga ctccttgcag ctgctgtcag catggcccag gctcctgctg      300

acccgggcag agaaggccac cttgaacaaa gaatcctgca ggtgctgaca gaggctggct      360

ccccggtgaa acttgcccag ctggtgaagg aatgccaagc acccaagagg gagctcaacc      420

aagtcctcta ccgaatgaaa aaggagttga aagtctccct cacatcccct gccacctggt      480

gcttgggcgg gactgatcct gaaggcgagg gtcctgcaga gctggccttg tccagccctg      540

ccgagaggcc ccagcaacat gcagctacaa ttccagagac ccctggccct cagttcagcc      600

aacaacggga ggaagacatc tacaggtttc tcaaagacaa tggtccccag agggccctgg      660

tcatcgccca agcactggga atgaggacag caaaagatgt gaaccgagac ttgtacagga      720

tgaagagcag gcaccttctg gacatggatg agcagtccaa agcatggacg atttaccgcc      780

cagaagattc tggaagaaga gcaaagtcag cctcaattat ttaccagcac aatccaatca      840

acatgatctg ccagaatgga cccaacagct ggatttccat tgcaaactcc gaagccatcc      900

agattggaca cgggaacatc attacaagac agacagtctc cagggaggac ggtaagtcac      960

ccaagagagc ccagggaggg gacctcggtg gggagccacc ggatcctctg ggtgggggca     1020

aagggtaggg atggggagtg gggggattct gccctccaag gggaaagggt tgcttccaga     1080

cccccacagt ccacctttac ggccgtcctg agaatgagga cacctggatc aaagctctcc     1140

tgatttccct gtactctgat actttctacc tcattttaaa gtttaattta atttttattt     1200

ttctaataaa attttaaaat taagatggga aaaaaaaaaa aaaaaaaaaa aaaaa          1255


<210>  164
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Ala Gln Ala Pro Ala Asp Pro Gly Arg Glu Gly His Leu Glu Gln 
1               5                   10                  15      


Arg Ile Leu Gln Val Leu Thr Glu Ala Gly Ser Pro Val Lys Leu Ala 
            20                  25                  30          


Gln Leu Val Lys Glu Cys Gln Ala Pro Lys Arg Glu Leu Asn Gln Val 
        35                  40                  45              


Leu Tyr Arg Met Lys Lys Glu Leu Lys Val Ser Leu Thr Ser Pro Ala 
    50                  55                  60                  


Thr Trp Cys Leu Gly Gly Thr Asp Pro Glu Gly Glu Gly Pro Ala Glu 
65                  70                  75                  80  


Leu Ala Leu Ser Ser Pro Ala Glu Arg Pro Gln Gln His Ala Ala Thr 
                85                  90                  95      


Ile Pro Glu Thr Pro Gly Pro Gln Phe Ser Gln Gln Arg Glu Glu Asp 
            100                 105                 110         


Ile Tyr Arg Phe Leu Lys Asp Asn Gly Pro Gln Arg Ala Leu Val Ile 
        115                 120                 125             


Ala Gln Ala Leu Gly Met Arg Thr Ala Lys Asp Val Asn Arg Asp Leu 
    130                 135                 140                 


Tyr Arg Met Lys Ser Arg His Leu Leu Asp Met Asp Glu Gln Ser Lys 
145                 150                 155                 160 


Ala Trp Thr Ile Tyr Arg Pro Glu Asp Ser Gly Arg Arg Ala Lys Ser 
                165                 170                 175     


Ala Ser Ile Ile Tyr Gln His Asn Pro Ile Asn Met Ile Cys Gln Asn 
            180                 185                 190         


Gly Pro Asn Ser Trp Ile Ser Ile Ala Asn Ser Glu Ala Ile Gln Ile 
        195                 200                 205             


Gly His Gly Asn Ile Ile Thr Arg Gln Thr Val Ser Arg Glu Asp Gly 
    210                 215                 220                 


Ser Ala Gly Pro Arg His Leu Pro Ser Met Ala Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Thr Trp Gly Thr Leu Val Asp Pro Trp Gly Pro Gln Asp Ile His Met 
                245                 250                 255     


Glu Gln Ser Ile Leu Arg Arg Val Gln Leu Gly His Ser Asn Glu Met 
            260                 265                 270         


Arg Leu His Gly Val Pro Ser Glu Gly Pro Ala His Ile Pro Pro Gly 
        275                 280                 285             


Ser Pro Pro Val Ser Ala Thr Ala Ala Gly Pro Glu Ala Ser Phe Glu 
    290                 295                 300                 


Ala Arg Ile Pro Ser Pro Gly Thr His Pro Glu Gly Glu Ala Ala Gln 
305                 310                 315                 320 


Arg Ile His Met Lys Ser Cys Phe Leu Glu Asp Ala Thr Ile Gly Asn 
                325                 330                 335     


Ser Asn Lys Met Ser Ile Ser Pro Gly Val Ala Gly Pro Gly Gly Val 
            340                 345                 350         


Ala Gly Ser Gly Glu Gly Glu Pro Gly Glu Asp Ala Gly Arg Arg Pro 
        355                 360                 365             


Ala Asp Thr Gln Ser Arg Ser His Phe Pro Arg Asp Ile Gly Gln Pro 
    370                 375                 380                 


Ile Thr Pro Ser His Ser Lys Leu Thr Pro Lys Leu Glu Thr Met Thr 
385                 390                 395                 400 


Leu Gly Asn Arg Ser His Lys Ala Ala Glu Gly Ser His Tyr Val Asp 
                405                 410                 415     


Glu Ala Ser His Glu Gly Ser Trp Trp Gly Gly Gly Ile 
            420                 425                 


<210>  165
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Ala Gln Ala Pro Ala Asp Pro Gly Arg Glu Ala Glu Arg Pro Gln 
1               5                   10                  15      


Gln His Ala Ala Thr Ile Pro Glu Thr Pro Gly Pro Gln Phe Ser Gln 
            20                  25                  30          


Gln Arg Glu Glu Asp Ile Tyr Arg Phe Leu Lys Asp Asn Gly Pro Gln 
        35                  40                  45              


Arg Ala Leu Val Ile Ala Gln Ala Leu Gly Met Arg Thr Ala Lys Asp 
    50                  55                  60                  


Val Asn Arg Asp Leu Tyr Arg Met Lys Ser Arg His Leu Leu Asp Met 
65                  70                  75                  80  


Asp Glu Gln Ser Lys Ala Trp Thr Ile Tyr Arg Pro Glu Asp Ser Gly 
                85                  90                  95      


Arg Arg Ala Lys Ser Ala Ser Ile Ile Tyr Gln His Asn Pro Ile Asn 
            100                 105                 110         


Met Ile Cys Gln Asn Gly Pro Asn Ser Trp Ile Ser Ile Ala Asn Ser 
        115                 120                 125             


Glu Ala Ile Gln Ile Gly His Gly Asn Ile Ile Thr Arg Gln Thr Val 
    130                 135                 140                 


Ser Arg Glu Asp Gly Ser Ala Gly Pro Arg His Leu Pro Ser Met Ala 
145                 150                 155                 160 


Pro Gly Asp Ser Ser Thr Trp Gly Thr Leu Val Asp Pro Trp Gly Pro 
                165                 170                 175     


Gln Asp Ile His Met Glu Gln Ser Ile Leu Arg Arg Val Gln Leu Gly 
            180                 185                 190         


His Ser Asn Glu Met Arg Leu His Gly Val Pro Ser Glu Gly Pro Ala 
        195                 200                 205             


His Ile Pro Pro Gly Ser Pro Pro Val Ser Ala Thr Ala Ala Gly Pro 
    210                 215                 220                 


Glu Ala Ser Phe Glu Ala Arg Ile Pro Ser Pro Gly Thr His Pro Glu 
225                 230                 235                 240 


Gly Glu Ala Ala Gln Arg Ile His Met Lys Ser Cys Phe Leu Glu Asp 
                245                 250                 255     


Ala Thr Ile Gly Asn Ser Asn Lys Met Ser Ile Ser Pro Gly Val Ala 
            260                 265                 270         


Gly Pro Gly Gly Val Ala Gly Ser Gly Glu Gly Glu Pro Gly Glu Asp 
        275                 280                 285             


Ala Gly Arg Arg Pro Ala Asp Thr Gln Ser Arg Ser His Phe Pro Arg 
    290                 295                 300                 


Asp Ile Gly Gln Pro Ile Thr Pro Ser His Ser Lys Leu Thr Pro Lys 
305                 310                 315                 320 


Leu Glu Thr Met Thr Leu Gly Asn Arg Ser His Lys Ala Ala Glu Gly 
                325                 330                 335     


Ser His Tyr Val Asp Glu Ala Ser His Glu Gly Ser Trp Trp Gly Gly 
            340                 345                 350         


Gly Ile 
        


<210>  166
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Ala Gln Ala Pro Ala Asp Pro Gly Arg Glu Gly His Leu Glu Gln 
1               5                   10                  15      


Arg Ile Leu Gln Val Leu Thr Glu Ala Gly Ser Pro Val Lys Leu Ala 
            20                  25                  30          


Gln Leu Val Lys Glu Cys Gln Ala Pro Lys Arg Glu Leu Asn Gln Val 
        35                  40                  45              


Leu Tyr Arg Met Lys Lys Glu Leu Lys Val Ser Leu Thr Ser Pro Ala 
    50                  55                  60                  


Thr Trp Cys Leu Gly Gly Thr Asp Pro Glu Gly Glu Gly Pro Ala Glu 
65                  70                  75                  80  


Leu Ala Leu Ser Ser Pro Ala Glu Arg Pro Gln Gln His Ala Ala Thr 
                85                  90                  95      


Ile Pro Glu Thr Pro Gly Pro Gln Phe Ser Gln Gln Arg Glu Glu Asp 
            100                 105                 110         


Ile Tyr Arg Phe Leu Lys Asp Asn Gly Pro Gln Arg Ala Leu Val Ile 
        115                 120                 125             


Ala Gln Ala Leu Gly Met Arg Thr Ala Lys Asp Val Asn Arg Asp Leu 
    130                 135                 140                 


Tyr Arg Met Lys Ser Arg His Leu Leu Asp Met Asp Glu Gln Ser Lys 
145                 150                 155                 160 


Ala Trp Thr Ile Tyr Arg Pro Glu Asp Ser Gly Arg Arg Ala Lys Ser 
                165                 170                 175     


Ala Ser Ile Ile Tyr Gln His Asn Pro Ile Asn Met Ile Cys Gln Asn 
            180                 185                 190         


Gly Pro Asn Ser Trp Ile Ser Ile Ala Asn Ser Glu Ala Ile Gln Ile 
        195                 200                 205             


Gly His Gly Asn Ile Ile Thr Arg Gln Thr Val Ser Arg Glu Asp Gly 
    210                 215                 220                 


Lys Ser Pro Lys Arg Ala Gln Gly Gly Asp Leu Gly Gly Glu Pro Pro 
225                 230                 235                 240 


Asp Pro Leu Gly Gly Gly Lys Gly 
                245             


