                         SEQUENCE LISTING

<110>  Sichuan Clover Biopharmaceuticals, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR PURIFICATION OF TRIMERIC FUSION 
       PROTEINS

<130>  P10892-PCT

<150>  PCT/CN2021/087055
<151>  2021-04-13

<150>  PCT/CN2020/112439
<151>  2020-08-31

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  1632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length Endo180-Fc (D1-10-Fc)

<400>  1

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 
1               5                   10                  15      


Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Gly Ala 
            20                  25                  30          


Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Val Phe Leu Ile Phe Ser 
        35                  40                  45              


His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val Arg Val 
    50                  55                  60                  


Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys Trp Val 
65                  70                  75                  80  


Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu Gly Thr 
                85                  90                  95      


Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr Glu Cys 
            100                 105                 110         


Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu Gly Asp 
        115                 120                 125             


Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser Lys Pro 
    130                 135                 140                 


Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp Arg Ile 
145                 150                 155                 160 


Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu Val Tyr 
                165                 170                 175     


Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro Phe Lys 
            180                 185                 190         


Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp 
        195                 200                 205             


Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp Glu Arg 
    210                 215                 220                 


Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe Trp Asp 
225                 230                 235                 240 


Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln Ser Thr 
                245                 250                 255     


Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly Ala Asp 
            260                 265                 270         


Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn Gly Leu 
        275                 280                 285             


Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp Leu Asp 
    290                 295                 300                 


Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu 
305                 310                 315                 320 


Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly 
                325                 330                 335     


Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp Cys Ser 
            340                 345                 350         


Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr Ala Glu 
        355                 360                 365             


Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys Glu Pro 
    370                 375                 380                 


Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala Glu Lys 
385                 390                 395                 400 


Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp 
                405                 410                 415     


Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr Lys Gln 
            420                 425                 430         


Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp Leu Lys 
        435                 440                 445             


Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr 
    450                 455                 460                 


His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp 
465                 470                 475                 480 


Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys 
                485                 490                 495     


Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu Ser Gln 
            500                 505                 510         


Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr Trp His 
        515                 520                 525             


Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr Ser Glu 
    530                 535                 540                 


Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr Ile Thr 
545                 550                 555                 560 


Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn Trp Glu 
                565                 570                 575     


Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr Gly Ser 
            580                 585                 590         


Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp Asn Arg 
        595                 600                 605             


Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala Thr Gly 
    610                 615                 620                 


Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe Arg Ala 
625                 630                 635                 640 


Arg Tyr Ile Cys Arg Gln Ser Leu Gly Thr Pro Val Thr Pro Glu Leu 
                645                 650                 655     


Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro Gln Gly 
            660                 665                 670         


Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe Ser Ser 
        675                 680                 685             


Glu Arg Leu Gln Asp Lys Lys Ser Trp Val Gln Ala Gln Gly Ala Cys 
    690                 695                 700                 


Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu Ala Ser Tyr Glu Glu Glu 
705                 710                 715                 720 


His Phe Val Ala Asn Met Leu Asn Lys Ile Phe Gly Glu Ser Glu Pro 
                725                 730                 735     


Glu Ile His Glu Gln His Trp Phe Trp Ile Gly Leu Asn Arg Arg Asp 
            740                 745                 750         


Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser Asp Gly Val Gly Phe Ser 
        755                 760                 765             


Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp Ile Arg Gly 
    770                 775                 780                 


Cys Ala Val Leu Asp Leu Ala Ser Leu Gln Trp Val Ala Met Gln Cys 
785                 790                 795                 800 


Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile Pro Arg Gly Thr Asp Val 
                805                 810                 815     


Arg Glu Pro Asp Asp Ser Pro Gln Gly Arg Arg Glu Trp Leu Arg Phe 
            820                 825                 830         


Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp Ala Gln 
        835                 840                 845             


Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser Val His 
    850                 855                 860                 


Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys Phe Ser 
865                 870                 875                 880 


Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser Glu Ser 
                885                 890                 895     


Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe Ile Ser 
            900                 905                 910         


Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys Cys Val 
        915                 920                 925             


Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys Leu Thr 
    930                 935                 940                 


Ala Leu Pro Tyr Ile Cys Lys Arg Ser Asn Val Thr Lys Glu Thr Gln 
945                 950                 955                 960 


Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser Asp Trp 
                965                 970                 975     


Ile Gln Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu Pro Gln 
            980                 985                 990         


Ser Arg Val Lys Trp Ser Glu Ala  Gln Phe Ser Cys Glu  Gln Gln Glu 
        995                 1000                 1005             


Ala Gln  Leu Val Thr Ile Thr  Asn Pro Leu Glu Gln  Ala Phe Ile 
    1010                 1015                 1020             


Thr Ala  Ser Leu Pro Asn Val  Thr Phe Asp Leu Trp  Ile Gly Leu 
    1025                 1030                 1035             


His Ala  Ser Gln Arg Asp Phe  Gln Trp Val Glu Gln  Glu Pro Leu 
    1040                 1045                 1050             


Met Tyr  Ala Asn Trp Ala Pro  Gly Glu Pro Ser Gly  Pro Ser Pro 
    1055                 1060                 1065             


Ala Pro  Ser Gly Asn Lys Pro  Thr Ser Cys Ala Val  Val Leu His 
    1070                 1075                 1080             


Ser Pro  Ser Ala His Phe Thr  Gly Arg Trp Asp Asp  Arg Ser Cys 
    1085                 1090                 1095             


Thr Glu  Glu Thr His Gly Phe  Ile Cys Gln Lys Gly  Thr Asp Pro 
    1100                 1105                 1110             


Ser Leu  Ser Pro Ser Pro Ala  Ala Leu Pro Pro Ala  Pro Gly Thr 
    1115                 1120                 1125             


Glu Leu  Ser Tyr Leu Asn Gly  Thr Phe Arg Leu Leu  Gln Lys Pro 
    1130                 1135                 1140             


Leu Arg  Trp His Asp Ala Leu  Leu Leu Cys Glu Ser  Arg Asn Ala 
    1145                 1150                 1155             


Ser Leu  Ala Tyr Val Pro Asp  Pro Tyr Thr Gln Ala  Phe Leu Thr 
    1160                 1165                 1170             


Gln Ala  Ala Arg Gly Leu Arg  Thr Pro Leu Trp Ile  Gly Leu Ala 
    1175                 1180                 1185             


Gly Glu  Glu Gly Ser Arg Arg  Tyr Ser Trp Val Ser  Glu Glu Pro 
    1190                 1195                 1200             


Leu Asn  Tyr Val Gly Trp Gln  Asp Gly Glu Pro Gln  Gln Pro Gly 
    1205                 1210                 1215             


Gly Cys  Thr Tyr Val Asp Val  Asp Gly Ala Trp Arg  Thr Thr Ser 
    1220                 1225                 1230             


Cys Asp  Thr Lys Leu Gln Gly  Ala Val Cys Gly Val  Ser Ser Gly 
    1235                 1240                 1245             


Pro Pro  Pro Pro Arg Arg Ile  Ser Tyr His Gly Ser  Cys Pro Gln 
    1250                 1255                 1260             


Gly Leu  Ala Asp Ser Ala Trp  Ile Pro Phe Arg Glu  His Cys Tyr 
    1265                 1270                 1275             


Ser Phe  His Met Glu Leu Leu  Leu Gly His Lys Glu  Ala Arg Gln 
    1280                 1285                 1290             


Arg Cys  Gln Arg Ala Gly Gly  Ala Val Leu Ser Ile  Leu Asp Glu 
    1295                 1300                 1305             


Met Glu  Asn Val Phe Val Trp  Glu His Leu Gln Ser  Tyr Glu Gly 
    1310                 1315                 1320             


Gln Ser  Arg Gly Ala Trp Leu  Gly Met Asn Phe Asn  Pro Lys Gly 
    1325                 1330                 1335             


Gly Thr  Leu Val Trp Gln Asp  Asn Thr Ala Val Asn  Tyr Ser Asn 
    1340                 1345                 1350             


Trp Gly  Pro Pro Gly Leu Gly  Pro Ser Met Leu Ser  His Asn Ser 
    1355                 1360                 1365             


Cys Tyr  Trp Ile Gln Ser Asn  Ser Gly Leu Trp Arg  Pro Gly Ala 
    1370                 1375                 1380             


Cys Thr  Asn Ile Thr Met Gly  Val Val Cys Lys Gln  Ala Tyr Val 
    1385                 1390                 1395             


Arg Ser  Glu Pro Lys Ser Cys  Asp Lys Thr His Thr  Cys Pro Pro 
    1400                 1405                 1410             


Cys Pro  Ala Pro Glu Leu Leu  Gly Gly Pro Ser Val  Phe Leu Phe 
    1415                 1420                 1425             


Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu 
    1430                 1435                 1440             


Val Thr  Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
    1445                 1450                 1455             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1460                 1465                 1470             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1475                 1480                 1485             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1490                 1495                 1500             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1505                 1510                 1515             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1520                 1525                 1530             


Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val 
    1535                 1540                 1545             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1550                 1555                 1560             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1565                 1570                 1575             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1580                 1585                 1590             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1595                 1600                 1605             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1610                 1615                 1620             


Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1625                 1630         


<210>  2
<211>  1602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature Endo-180-Fc(D1-10-Fc)

<400>  2

Gly Ala Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Val Phe Leu Ile 
1               5                   10                  15      


Phe Ser His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val 
            20                  25                  30          


Arg Val Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys 
        35                  40                  45              


Trp Val Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu 
    50                  55                  60                  


Gly Thr Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr 
65                  70                  75                  80  


Glu Cys Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu 
                85                  90                  95      


Gly Asp Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser 
            100                 105                 110         


Lys Pro Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp 
        115                 120                 125             


Arg Ile Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu 
    130                 135                 140                 


Val Tyr Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro 
145                 150                 155                 160 


Phe Lys Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg 
                165                 170                 175     


Glu Asp Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp 
            180                 185                 190         


Glu Arg Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe 
        195                 200                 205             


Trp Asp Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln 
    210                 215                 220                 


Ser Thr Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly 
225                 230                 235                 240 


Ala Asp Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn 
                245                 250                 255     


Gly Leu Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp 
            260                 265                 270         


Leu Asp Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys 
        275                 280                 285             


Tyr Leu Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn 
    290                 295                 300                 


Cys Gly Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp 
305                 310                 315                 320 


Cys Ser Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr 
                325                 330                 335     


Ala Glu Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys 
            340                 345                 350         


Glu Pro Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala 
        355                 360                 365             


Glu Lys Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly 
    370                 375                 380                 


Gly Asp Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr 
385                 390                 395                 400 


Lys Gln Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp 
                405                 410                 415     


Leu Lys Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser 
            420                 425                 430         


Phe Thr His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu 
        435                 440                 445             


Glu Asp Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser 
    450                 455                 460                 


Pro Cys Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu 
465                 470                 475                 480 


Ser Gln Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr 
                485                 490                 495     


Trp His Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr 
            500                 505                 510         


Ser Glu Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr 
        515                 520                 525             


Ile Thr Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn 
    530                 535                 540                 


Trp Glu Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr 
545                 550                 555                 560 


Gly Ser Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp 
                565                 570                 575     


Asn Arg Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala 
            580                 585                 590         


Thr Gly Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe 
        595                 600                 605             


Arg Ala Arg Tyr Ile Cys Arg Gln Ser Leu Gly Thr Pro Val Thr Pro 
    610                 615                 620                 


Glu Leu Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro 
625                 630                 635                 640 


Gln Gly Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe 
                645                 650                 655     


Ser Ser Glu Arg Leu Gln Asp Lys Lys Ser Trp Val Gln Ala Gln Gly 
            660                 665                 670         


Ala Cys Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu Ala Ser Tyr Glu 
        675                 680                 685             


Glu Glu His Phe Val Ala Asn Met Leu Asn Lys Ile Phe Gly Glu Ser 
    690                 695                 700                 


Glu Pro Glu Ile His Glu Gln His Trp Phe Trp Ile Gly Leu Asn Arg 
705                 710                 715                 720 


Arg Asp Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser Asp Gly Val Gly 
                725                 730                 735     


Phe Ser Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp Ile 
            740                 745                 750         


Arg Gly Cys Ala Val Leu Asp Leu Ala Ser Leu Gln Trp Val Ala Met 
        755                 760                 765             


Gln Cys Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile Pro Arg Gly Thr 
    770                 775                 780                 


Asp Val Arg Glu Pro Asp Asp Ser Pro Gln Gly Arg Arg Glu Trp Leu 
785                 790                 795                 800 


Arg Phe Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp 
                805                 810                 815     


Ala Gln Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser 
            820                 825                 830         


Val His Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys 
        835                 840                 845             


Phe Ser Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser 
    850                 855                 860                 


Glu Ser Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe 
865                 870                 875                 880 


Ile Ser Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys 
                885                 890                 895     


Cys Val Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys 
            900                 905                 910         


Leu Thr Ala Leu Pro Tyr Ile Cys Lys Arg Ser Asn Val Thr Lys Glu 
        915                 920                 925             


Thr Gln Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser 
    930                 935                 940                 


Asp Trp Ile Gln Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu 
945                 950                 955                 960 


Pro Gln Ser Arg Val Lys Trp Ser Glu Ala Gln Phe Ser Cys Glu Gln 
                965                 970                 975     


Gln Glu Ala Gln Leu Val Thr Ile Thr Asn Pro Leu Glu Gln Ala Phe 
            980                 985                 990         


Ile Thr Ala Ser Leu Pro Asn Val  Thr Phe Asp Leu Trp  Ile Gly Leu 
        995                 1000                 1005             


His Ala  Ser Gln Arg Asp Phe  Gln Trp Val Glu Gln  Glu Pro Leu 
    1010                 1015                 1020             


Met Tyr  Ala Asn Trp Ala Pro  Gly Glu Pro Ser Gly  Pro Ser Pro 
    1025                 1030                 1035             


Ala Pro  Ser Gly Asn Lys Pro  Thr Ser Cys Ala Val  Val Leu His 
    1040                 1045                 1050             


Ser Pro  Ser Ala His Phe Thr  Gly Arg Trp Asp Asp  Arg Ser Cys 
    1055                 1060                 1065             


Thr Glu  Glu Thr His Gly Phe  Ile Cys Gln Lys Gly  Thr Asp Pro 
    1070                 1075                 1080             


Ser Leu  Ser Pro Ser Pro Ala  Ala Leu Pro Pro Ala  Pro Gly Thr 
    1085                 1090                 1095             


Glu Leu  Ser Tyr Leu Asn Gly  Thr Phe Arg Leu Leu  Gln Lys Pro 
    1100                 1105                 1110             


Leu Arg  Trp His Asp Ala Leu  Leu Leu Cys Glu Ser  Arg Asn Ala 
    1115                 1120                 1125             


Ser Leu  Ala Tyr Val Pro Asp  Pro Tyr Thr Gln Ala  Phe Leu Thr 
    1130                 1135                 1140             


Gln Ala  Ala Arg Gly Leu Arg  Thr Pro Leu Trp Ile  Gly Leu Ala 
    1145                 1150                 1155             


Gly Glu  Glu Gly Ser Arg Arg  Tyr Ser Trp Val Ser  Glu Glu Pro 
    1160                 1165                 1170             


Leu Asn  Tyr Val Gly Trp Gln  Asp Gly Glu Pro Gln  Gln Pro Gly 
    1175                 1180                 1185             


Gly Cys  Thr Tyr Val Asp Val  Asp Gly Ala Trp Arg  Thr Thr Ser 
    1190                 1195                 1200             


Cys Asp  Thr Lys Leu Gln Gly  Ala Val Cys Gly Val  Ser Ser Gly 
    1205                 1210                 1215             


Pro Pro  Pro Pro Arg Arg Ile  Ser Tyr His Gly Ser  Cys Pro Gln 
    1220                 1225                 1230             


Gly Leu  Ala Asp Ser Ala Trp  Ile Pro Phe Arg Glu  His Cys Tyr 
    1235                 1240                 1245             


Ser Phe  His Met Glu Leu Leu  Leu Gly His Lys Glu  Ala Arg Gln 
    1250                 1255                 1260             


Arg Cys  Gln Arg Ala Gly Gly  Ala Val Leu Ser Ile  Leu Asp Glu 
    1265                 1270                 1275             


Met Glu  Asn Val Phe Val Trp  Glu His Leu Gln Ser  Tyr Glu Gly 
    1280                 1285                 1290             


Gln Ser  Arg Gly Ala Trp Leu  Gly Met Asn Phe Asn  Pro Lys Gly 
    1295                 1300                 1305             


Gly Thr  Leu Val Trp Gln Asp  Asn Thr Ala Val Asn  Tyr Ser Asn 
    1310                 1315                 1320             


Trp Gly  Pro Pro Gly Leu Gly  Pro Ser Met Leu Ser  His Asn Ser 
    1325                 1330                 1335             


Cys Tyr  Trp Ile Gln Ser Asn  Ser Gly Leu Trp Arg  Pro Gly Ala 
    1340                 1345                 1350             


Cys Thr  Asn Ile Thr Met Gly  Val Val Cys Lys Gln  Ala Tyr Val 
    1355                 1360                 1365             


Arg Ser  Glu Pro Lys Ser Cys  Asp Lys Thr His Thr  Cys Pro Pro 
    1370                 1375                 1380             


Cys Pro  Ala Pro Glu Leu Leu  Gly Gly Pro Ser Val  Phe Leu Phe 
    1385                 1390                 1395             


Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu 
    1400                 1405                 1410             


Val Thr  Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
    1415                 1420                 1425             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1430                 1435                 1440             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1445                 1450                 1455             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1460                 1465                 1470             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1475                 1480                 1485             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1490                 1495                 1500             


Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val 
    1505                 1510                 1515             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1520                 1525                 1530             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1535                 1540                 1545             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1550                 1555                 1560             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1565                 1570                 1575             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1580                 1585                 1590             


Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1595                 1600         


<210>  3
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full Length D6-Fc

<400>  3

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 
1               5                   10                  15      


Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Arg Ser 
            20                  25                  30          


Pro Val Thr Pro Glu Leu Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr 
        35                  40                  45              


Gly Ser Cys Pro Gln Gly Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys 
    50                  55                  60                  


Tyr Lys Val Phe Ser Ser Glu Arg Leu Gln Asp Lys Lys Ser Trp Val 
65                  70                  75                  80  


Gln Ala Gln Gly Ala Cys Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu 
                85                  90                  95      


Ala Ser Tyr Glu Glu Glu His Phe Val Ala Asn Met Leu Asn Lys Ile 
            100                 105                 110         


Phe Gly Glu Ser Glu Pro Glu Ile His Glu Gln His Trp Phe Trp Ile 
        115                 120                 125             


Gly Leu Asn Arg Arg Asp Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser 
    130                 135                 140                 


Asp Gly Val Gly Phe Ser Tyr His Asn Phe Asp Arg Ser Arg His Asp 
145                 150                 155                 160 


Asp Asp Asp Ile Arg Gly Cys Ala Val Leu Asp Leu Ala Ser Leu Gln 
                165                 170                 175     


Trp Val Ala Met Gln Cys Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile 
            180                 185                 190         


Pro Arg Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        195                 200                 205             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    210                 215                 220                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
225                 230                 235                 240 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                245                 250                 255     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            260                 265                 270         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        275                 280                 285             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    290                 295                 300                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
305                 310                 315                 320 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                325                 330                 335     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            340                 345                 350         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        355                 360                 365             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    370                 375                 380                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
385                 390                 395                 400 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                405                 410                 415     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425         


<210>  4
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature D6-Fc

<400>  4

Arg Ser Pro Val Thr Pro Glu Leu Pro Gly Pro Asp Pro Thr Pro Ser 
1               5                   10                  15      


Leu Thr Gly Ser Cys Pro Gln Gly Trp Ala Ser Asp Thr Lys Leu Arg 
            20                  25                  30          


Tyr Cys Tyr Lys Val Phe Ser Ser Glu Arg Leu Gln Asp Lys Lys Ser 
        35                  40                  45              


Trp Val Gln Ala Gln Gly Ala Cys Gln Glu Leu Gly Ala Gln Leu Leu 
    50                  55                  60                  


Ser Leu Ala Ser Tyr Glu Glu Glu His Phe Val Ala Asn Met Leu Asn 
65                  70                  75                  80  


Lys Ile Phe Gly Glu Ser Glu Pro Glu Ile His Glu Gln His Trp Phe 
                85                  90                  95      


Trp Ile Gly Leu Asn Arg Arg Asp Pro Arg Gly Gly Gln Ser Trp Arg 
            100                 105                 110         


Trp Ser Asp Gly Val Gly Phe Ser Tyr His Asn Phe Asp Arg Ser Arg 
        115                 120                 125             


His Asp Asp Asp Asp Ile Arg Gly Cys Ala Val Leu Asp Leu Ala Ser 
    130                 135                 140                 


Leu Gln Trp Val Ala Met Gln Cys Asp Thr Gln Leu Asp Trp Ile Cys 
145                 150                 155                 160 


Lys Ile Pro Arg Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                165                 170                 175     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            180                 185                 190         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        195                 200                 205             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    210                 215                 220                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
225                 230                 235                 240 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                245                 250                 255     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            260                 265                 270         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        275                 280                 285             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    290                 295                 300                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
305                 310                 315                 320 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                325                 330                 335     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            340                 345                 350         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        355                 360                 365             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    370                 375                 380                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395         


<210>  5
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Peptide

<400>  5

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 
1               5                   10                  15      


Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro 
            20                  25                  30  


<210>  6
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc

<400>  6

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  7
<211>  1384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature Endo180 Ecto-domain (Uniprot Q9UBG0)

<400>  7

Gly Ala Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Val Phe Leu Ile 
1               5                   10                  15      


Phe Ser His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val 
            20                  25                  30          


Arg Val Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys 
        35                  40                  45              


Trp Val Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu 
    50                  55                  60                  


Gly Thr Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr 
65                  70                  75                  80  


Glu Cys Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu 
                85                  90                  95      


Gly Asp Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser 
            100                 105                 110         


Lys Pro Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp 
        115                 120                 125             


Arg Ile Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu 
    130                 135                 140                 


Val Tyr Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro 
145                 150                 155                 160 


Phe Lys Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg 
                165                 170                 175     


Glu Asp Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp 
            180                 185                 190         


Glu Arg Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe 
        195                 200                 205             


Trp Asp Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln 
    210                 215                 220                 


Ser Thr Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly 
225                 230                 235                 240 


Ala Asp Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn 
                245                 250                 255     


Gly Leu Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp 
            260                 265                 270         


Leu Asp Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys 
        275                 280                 285             


Tyr Leu Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn 
    290                 295                 300                 


Cys Gly Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp 
305                 310                 315                 320 


Cys Ser Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr 
                325                 330                 335     


Ala Glu Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys 
            340                 345                 350         


Glu Pro Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala 
        355                 360                 365             


Glu Lys Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly 
    370                 375                 380                 


Gly Asp Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr 
385                 390                 395                 400 


Lys Gln Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp 
                405                 410                 415     


Leu Lys Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser 
            420                 425                 430         


Phe Thr His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu 
        435                 440                 445             


Glu Asp Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser 
    450                 455                 460                 


Pro Cys Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu 
465                 470                 475                 480 


Ser Gln Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr 
                485                 490                 495     


Trp His Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr 
            500                 505                 510         


Ser Glu Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr 
        515                 520                 525             


Ile Thr Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn 
    530                 535                 540                 


Trp Glu Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr 
545                 550                 555                 560 


Gly Ser Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp 
                565                 570                 575     


Asn Arg Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala 
            580                 585                 590         


Thr Gly Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe 
        595                 600                 605             


Arg Ala Arg Tyr Ile Cys Arg Gln Ser Leu Gly Thr Pro Val Thr Pro 
    610                 615                 620                 


Glu Leu Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro 
625                 630                 635                 640 


Gln Gly Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe 
                645                 650                 655     


Ser Ser Glu Arg Leu Gln Asp Lys Lys Ser Trp Val Gln Ala Gln Gly 
            660                 665                 670         


Ala Cys Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu Ala Ser Tyr Glu 
        675                 680                 685             


Glu Glu His Phe Val Ala Asn Met Leu Asn Lys Ile Phe Gly Glu Ser 
    690                 695                 700                 


Glu Pro Glu Ile His Glu Gln His Trp Phe Trp Ile Gly Leu Asn Arg 
705                 710                 715                 720 


Arg Asp Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser Asp Gly Val Gly 
                725                 730                 735     


Phe Ser Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp Ile 
            740                 745                 750         


Arg Gly Cys Ala Val Leu Asp Leu Ala Ser Leu Gln Trp Val Ala Met 
        755                 760                 765             


Gln Cys Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile Pro Arg Gly Thr 
    770                 775                 780                 


Asp Val Arg Glu Pro Asp Asp Ser Pro Gln Gly Arg Arg Glu Trp Leu 
785                 790                 795                 800 


Arg Phe Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp 
                805                 810                 815     


Ala Gln Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser 
            820                 825                 830         


Val His Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys 
        835                 840                 845             


Phe Ser Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser 
    850                 855                 860                 


Glu Ser Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe 
865                 870                 875                 880 


Ile Ser Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys 
                885                 890                 895     


Cys Val Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys 
            900                 905                 910         


Leu Thr Ala Leu Pro Tyr Ile Cys Lys Arg Ser Asn Val Thr Lys Glu 
        915                 920                 925             


Thr Gln Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser 
    930                 935                 940                 


Asp Trp Ile Gln Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu 
945                 950                 955                 960 


Pro Gln Ser Arg Val Lys Trp Ser Glu Ala Gln Phe Ser Cys Glu Gln 
                965                 970                 975     


Gln Glu Ala Gln Leu Val Thr Ile Thr Asn Pro Leu Glu Gln Ala Phe 
            980                 985                 990         


Ile Thr Ala Ser Leu Pro Asn Val  Thr Phe Asp Leu Trp  Ile Gly Leu 
        995                 1000                 1005             


His Ala  Ser Gln Arg Asp Phe  Gln Trp Val Glu Gln  Glu Pro Leu 
    1010                 1015                 1020             


Met Tyr  Ala Asn Trp Ala Pro  Gly Glu Pro Ser Gly  Pro Ser Pro 
    1025                 1030                 1035             


Ala Pro  Ser Gly Asn Lys Pro  Thr Ser Cys Ala Val  Val Leu His 
    1040                 1045                 1050             


Ser Pro  Ser Ala His Phe Thr  Gly Arg Trp Asp Asp  Arg Ser Cys 
    1055                 1060                 1065             


Thr Glu  Glu Thr His Gly Phe  Ile Cys Gln Lys Gly  Thr Asp Pro 
    1070                 1075                 1080             


Ser Leu  Ser Pro Ser Pro Ala  Ala Leu Pro Pro Ala  Pro Gly Thr 
    1085                 1090                 1095             


Glu Leu  Ser Tyr Leu Asn Gly  Thr Phe Arg Leu Leu  Gln Lys Pro 
    1100                 1105                 1110             


Leu Arg  Trp His Asp Ala Leu  Leu Leu Cys Glu Ser  Arg Asn Ala 
    1115                 1120                 1125             


Ser Leu  Ala Tyr Val Pro Asp  Pro Tyr Thr Gln Ala  Phe Leu Thr 
    1130                 1135                 1140             


Gln Ala  Ala Arg Gly Leu Arg  Thr Pro Leu Trp Ile  Gly Leu Ala 
    1145                 1150                 1155             


Gly Glu  Glu Gly Ser Arg Arg  Tyr Ser Trp Val Ser  Glu Glu Pro 
    1160                 1165                 1170             


Leu Asn  Tyr Val Gly Trp Gln  Asp Gly Glu Pro Gln  Gln Pro Gly 
    1175                 1180                 1185             


Gly Cys  Thr Tyr Val Asp Val  Asp Gly Ala Trp Arg  Thr Thr Ser 
    1190                 1195                 1200             


Cys Asp  Thr Lys Leu Gln Gly  Ala Val Cys Gly Val  Ser Ser Gly 
    1205                 1210                 1215             


Pro Pro  Pro Pro Arg Arg Ile  Ser Tyr His Gly Ser  Cys Pro Gln 
    1220                 1225                 1230             


Gly Leu  Ala Asp Ser Ala Trp  Ile Pro Phe Arg Glu  His Cys Tyr 
    1235                 1240                 1245             


Ser Phe  His Met Glu Leu Leu  Leu Gly His Lys Glu  Ala Arg Gln 
    1250                 1255                 1260             


Arg Cys  Gln Arg Ala Gly Gly  Ala Val Leu Ser Ile  Leu Asp Glu 
    1265                 1270                 1275             


Met Glu  Asn Val Phe Val Trp  Glu His Leu Gln Ser  Tyr Glu Gly 
    1280                 1285                 1290             


Gln Ser  Arg Gly Ala Trp Leu  Gly Met Asn Phe Asn  Pro Lys Gly 
    1295                 1300                 1305             


Gly Thr  Leu Val Trp Gln Asp  Asn Thr Ala Val Asn  Tyr Ser Asn 
    1310                 1315                 1320             


Trp Gly  Pro Pro Gly Leu Gly  Pro Ser Met Leu Ser  His Asn Ser 
    1325                 1330                 1335             


Cys Tyr  Trp Ile Gln Ser Asn  Ser Gly Leu Trp Arg  Pro Gly Ala 
    1340                 1345                 1350             


Cys Thr  Asn Ile Thr Met Gly  Val Val Cys Lys Leu  Pro Arg Ala 
    1355                 1360                 1365             


Glu Gln  Ser Ser Phe Ser Pro  Ser Ala Leu Pro Glu  Asn Pro Ala 
    1370                 1375                 1380             


Ala 
    


<210>  8
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1 (Ricin B-type lectin domain)

<400>  8

Pro Asn Val Phe Leu Ile Phe Ser His Gly Leu Gln Gly Cys Leu Glu 
1               5                   10                  15      


Ala Gln Gly Gly Gln Val Arg Val Thr Pro Ala Cys Asn Thr Ser Leu 
            20                  25                  30          


Pro Ala Gln Arg Trp Lys Trp Val Ser Arg Asn Arg Leu Phe Asn Leu 
        35                  40                  45              


Gly Thr Met Gln Cys Leu Gly Thr Gly Trp Pro Gly Thr Asn Thr Thr 
    50                  55                  60                  


Ala Ser Leu Gly Met Tyr Glu Cys Asp Arg Glu Ala Leu Asn Leu Arg 
65                  70                  75                  80  


Trp His Cys Arg Thr Leu Gly Asp Gln Leu Ser Leu Leu Leu Gly Ala 
                85                  90                  95      


Arg Thr Ser Asn Ile Ser Lys Pro Gly Thr Leu Glu Arg Gly Asp Gln 
            100                 105                 110         


Thr Arg Ser Gly Gln Trp Arg Ile Tyr Gly Ser Glu Glu Asp Leu 
        115                 120                 125         


<210>  9
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D2 (Fibronectin type-II domain)

<400>  9

Ser His Gly Lys Pro Cys Thr Ile Pro Phe Lys Tyr Asp Asn Gln Trp 
1               5                   10                  15      


Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp Gly His Leu Trp Cys 
            20                  25                  30          


Ala Thr Thr Gln Asp Tyr Gly Lys Asp Glu Arg Trp Gly Phe Cys Pro 
        35                  40                  45              


Ile 
    


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D3 (C-type lectin 1)

<400>  10

Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln Ser Thr Leu Ser Trp 
1               5                   10                  15      


Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly Ala Asp Leu Leu Ser 
            20                  25                  30          


Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn Gly Leu Leu Thr Gly 
        35                  40                  45              


Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp Leu Asp Thr Ser Gly 
    50                  55                  60                  


Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu Asn Trp Glu 
65                  70                  75                  80  


Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly Val Ile Arg 
                85                  90                  95      


Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp Cys Ser Ile Ala Leu 
            100                 105                 110         


Pro Tyr Val Cys Lys 
        115         


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D4 (C-type lectin 2)

<400>  11

Phe Gln Gly His Cys Tyr Arg Leu Gln Ala Glu Lys Arg Ser Trp Gln 
1               5                   10                  15      


Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp Leu Val Ser Ile 
            20                  25                  30          


His Ser Met Ala Glu Leu Glu Phe Ile Thr Lys Gln Ile Lys Gln Glu 
        35                  40                  45              


Val Glu Glu Leu Trp Ile Gly Leu Asn Asp Leu Lys Leu Gln Met Asn 
    50                  55                  60                  


Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr His Trp His Pro 
65                  70                  75                  80  


Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp Cys Val Thr Ile 
                85                  90                  95      


Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys Asn Gln Ser Leu 
            100                 105                 110         


Pro Ser Ile Cys Lys 
        115         


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D5 (C-type lectin 3)

<400>  12

His Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr Ser 
1               5                   10                  15      


Glu Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr Ile 
            20                  25                  30          


Thr Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn Trp 
        35                  40                  45              


Glu Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr Gly 
    50                  55                  60                  


Ser Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp Asn 
65                  70                  75                  80  


Arg Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala Thr 
                85                  90                  95      


Gly Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe Arg 
            100                 105                 110         


Ala Arg Tyr Ile Cys 
        115         


<210>  13
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D6 (C-type lectin 4)

<400>  13

Lys Leu Arg Tyr Cys Tyr Lys Val Phe Ser Ser Glu Arg Leu Gln Asp 
1               5                   10                  15      


Lys Lys Ser Trp Val Gln Ala Gln Gly Ala Cys Gln Glu Leu Gly Ala 
            20                  25                  30          


Gln Leu Leu Ser Leu Ala Ser Tyr Glu Glu Glu His Phe Val Ala Asn 
        35                  40                  45              


Met Leu Asn Lys Ile Phe Gly Glu Ser Glu Pro Glu Ile His Glu Gln 
    50                  55                  60                  


His Trp Phe Trp Ile Gly Leu Asn Arg Arg Asp Pro Arg Gly Gly Gln 
65                  70                  75                  80  


Ser Trp Arg Trp Ser Asp Gly Val Gly Phe Ser Tyr His Asn Phe Asp 
                85                  90                  95      


Arg Ser Arg His Asp Asp Asp Asp Ile Arg Gly Cys Ala Val Leu Asp 
            100                 105                 110         


Leu Ala Ser Leu Gln Trp Val Ala Met Gln Cys Asp Thr Gln Leu Asp 
        115                 120                 125             


Trp Ile Cys Lys 
    130         


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D7 (C-type lectin 5)

<400>  14

Phe Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp Ala 
1               5                   10                  15      


Gln Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser Val 
            20                  25                  30          


His Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys Phe 
        35                  40                  45              


Ser Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser Glu 
    50                  55                  60                  


Ser Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe Ile 
65                  70                  75                  80  


Ser Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys Cys 
                85                  90                  95      


Val Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys Leu 
            100                 105                 110         


Thr Ala Leu Pro Tyr Ile Cys Lys 
        115                 120 


<210>  15
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D8 (C-type lectin 6)

<400>  15

Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu Pro Gln Ser Arg 
1               5                   10                  15      


Val Lys Trp Ser Glu Ala Gln Phe Ser Cys Glu Gln Gln Glu Ala Gln 
            20                  25                  30          


Leu Val Thr Ile Thr Asn Pro Leu Glu Gln Ala Phe Ile Thr Ala Ser 
        35                  40                  45              


Leu Pro Asn Val Thr Phe Asp Leu Trp Ile Gly Leu His Ala Ser Gln 
    50                  55                  60                  


Arg Asp Phe Gln Trp Val Glu Gln Glu Pro Leu Met Tyr Ala Asn Trp 
65                  70                  75                  80  


Ala Pro Gly Glu Pro Ser Gly Pro Ser Pro Ala Pro Ser Gly Asn Lys 
                85                  90                  95      


Pro Thr Ser Cys Ala Val Val Leu His Ser Pro Ser Ala His Phe Thr 
            100                 105                 110         


Gly Arg Trp Asp Asp Arg Ser Cys Thr Glu Glu Thr His Gly Phe Ile 
        115                 120                 125             


Cys 
    


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D9 (C-type lectin 7)

<400>  16

Tyr Leu Asn Gly Thr Phe Arg Leu Leu Gln Lys Pro Leu Arg Trp His 
1               5                   10                  15      


Asp Ala Leu Leu Leu Cys Glu Ser Arg Asn Ala Ser Leu Ala Tyr Val 
            20                  25                  30          


Pro Asp Pro Tyr Thr Gln Ala Phe Leu Thr Gln Ala Ala Arg Gly Leu 
        35                  40                  45              


Arg Thr Pro Leu Trp Ile Gly Leu Ala Gly Glu Glu Gly Ser Arg Arg 
    50                  55                  60                  


Tyr Ser Trp Val Ser Glu Glu Pro Leu Asn Tyr Val Gly Trp Gln Asp 
65                  70                  75                  80  


Gly Glu Pro Gln Gln Pro Gly Gly Cys Thr Tyr Val Asp Val Asp Gly 
                85                  90                  95      


Ala Trp Arg Thr Thr Ser Cys Asp Thr Lys Leu Gln Gly Ala Val Cys 
            100                 105                 110         


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D10 (C-type lectin 8)

<400>  17

Phe Arg Glu His Cys Tyr Ser Phe His Met Glu Leu Leu Leu Gly His 
1               5                   10                  15      


Lys Glu Ala Arg Gln Arg Cys Gln Arg Ala Gly Gly Ala Val Leu Ser 
            20                  25                  30          


Ile Leu Asp Glu Met Glu Asn Val Phe Val Trp Glu His Leu Gln Ser 
        35                  40                  45              


Tyr Glu Gly Gln Ser Arg Gly Ala Trp Leu Gly Met Asn Phe Asn Pro 
    50                  55                  60                  


Lys Gly Gly Thr Leu Val Trp Gln Asp Asn Thr Ala Val Asn Tyr Ser 
65                  70                  75                  80  


Asn Trp Gly Pro Pro Gly Leu Gly Pro Ser Met Leu Ser His Asn Ser 
                85                  90                  95      


Cys Tyr Trp Ile Gln Ser Asn Ser Gly Leu Trp Arg Pro Gly Ala Cys 
            100                 105                 110         


Thr Asn Ile Thr Met Gly Val Val Cys 
        115                 120     


<210>  18
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I) with glycine-X-Y repeats and D→N 
       mutation at BMP-1 site, KS version

<400>  18

Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Arg Thr 
1               5                   10                  15      


Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu Pro Gln 
        35                  40                  45              


Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg Ala Asn 
    50                  55                  60                  


Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu 
65                  70                  75                  80  


Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Ser 
                85                  90                  95      


Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser 
            100                 105                 110         


Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn 
        115                 120                 125             


Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys 
    130                 135                 140                 


Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser 
145                 150                 155                 160 


Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met Thr 
                165                 170                 175     


Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp 
            180                 185                 190         


Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser 
        195                 200                 205             


Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln 
    210                 215                 220                 


Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser Asn Glu 
225                 230                 235                 240 


Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr 
                245                 250                 255     


Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val Ile 
            260                 265                 270         


Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp Val Ala 
        275                 280                 285             


Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val Gly 
    290                 295                 300                 


Pro Val Cys Phe Leu 
305                 


<210>  19
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I) with glycine-X-Y repeats and A→N 
       mutation at BMP-1 site, KS version

<400>  19

Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Arg Thr 
1               5                   10                  15      


Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu Pro Gln 
        35                  40                  45              


Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg Asn Asp 
    50                  55                  60                  


Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu 
65                  70                  75                  80  


Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Ser 
                85                  90                  95      


Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser 
            100                 105                 110         


Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn 
        115                 120                 125             


Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys 
    130                 135                 140                 


Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser 
145                 150                 155                 160 


Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met Thr 
                165                 170                 175     


Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp 
            180                 185                 190         


Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser 
        195                 200                 205             


Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln 
    210                 215                 220                 


Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser Asn Glu 
225                 230                 235                 240 


Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr 
                245                 250                 255     


Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val Ile 
            260                 265                 270         


Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp Val Ala 
        275                 280                 285             


Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val Gly 
    290                 295                 300                 


Pro Val Cys Phe Leu 
305                 


<210>  20
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I) with glycine-X-Y repeats and D→N 
       mutation at BMP-1 site, KS version

<400>  20

Arg Ser Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly 
1               5                   10                  15      


Arg Thr Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu 
        35                  40                  45              


Pro Gln Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg 
    50                  55                  60                  


Ala Asn Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr 
65                  70                  75                  80  


Thr Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu 
                85                  90                  95      


Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys 
            100                 105                 110         


His Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly 
        115                 120                 125             


Cys Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu 
    130                 135                 140                 


Thr Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr 
145                 150                 155                 160 


Ile Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser 
                165                 170                 175     


Met Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro 
            180                 185                 190         


Ala Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu 
        195                 200                 205             


Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met 
    210                 215                 220                 


Asp Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser 
225                 230                 235                 240 


Asn Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser 
                245                 250                 255     


Val Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr 
            260                 265                 270         


Val Ile Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp 
        275                 280                 285             


Val Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp 
    290                 295                 300                 


Val Gly Pro Val Cys Phe Leu 
305                 310     


<210>  21
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I) with glycine-X-Y repeats and D→N 
       mutation at BMP-1 site, KS version

<400>  21

Gly Ser Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly 
1               5                   10                  15      


Arg Thr Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu 
        35                  40                  45              


Pro Gln Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg 
    50                  55                  60                  


Ala Asn Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr 
65                  70                  75                  80  


Thr Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu 
                85                  90                  95      


Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys 
            100                 105                 110         


His Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly 
        115                 120                 125             


Cys Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu 
    130                 135                 140                 


Thr Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr 
145                 150                 155                 160 


Ile Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser 
                165                 170                 175     


Met Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro 
            180                 185                 190         


Ala Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu 
        195                 200                 205             


Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met 
    210                 215                 220                 


Asp Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser 
225                 230                 235                 240 


Asn Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser 
                245                 250                 255     


Val Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr 
            260                 265                 270         


Val Ile Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp 
        275                 280                 285             


Val Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp 
    290                 295                 300                 


Val Gly Pro Val Cys Phe Leu 
305                 310     


<210>  22
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I) with glycine-X-Y repeats, no BMP-1
       site mutation, KS version

<400>  22

Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Arg Thr 
1               5                   10                  15      


Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu Pro Gln 
        35                  40                  45              


Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg Ala Asp 
    50                  55                  60                  


Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu 
65                  70                  75                  80  


Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Ser 
                85                  90                  95      


Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser 
            100                 105                 110         


Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn 
        115                 120                 125             


Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys 
    130                 135                 140                 


Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser 
145                 150                 155                 160 


Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met Thr 
                165                 170                 175     


Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp 
            180                 185                 190         


Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser 
        195                 200                 205             


Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln 
    210                 215                 220                 


Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser Asn Glu 
225                 230                 235                 240 


Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr 
                245                 250                 255     


Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val Ile 
            260                 265                 270         


Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp Val Ala 
        275                 280                 285             


Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val Gly 
    290                 295                 300                 


Pro Val Cys Phe Leu 
305                 


<210>  23
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I) with glycine-X-Y repeats, no BMP-1
       site mutation, KS version

<400>  23

Ser Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Arg 
1               5                   10                  15      


Thr Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro Pro 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu Pro 
        35                  40                  45              


Gln Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg Ala 
    50                  55                  60                  


Asp Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr 
65                  70                  75                  80  


Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly 
                85                  90                  95      


Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His 
            100                 105                 110         


Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys 
        115                 120                 125             


Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr 
    130                 135                 140                 


Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile 
145                 150                 155                 160 


Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met 
                165                 170                 175     


Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala 
            180                 185                 190         


Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala 
        195                 200                 205             


Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp 
    210                 215                 220                 


Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser Asn 
225                 230                 235                 240 


Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val 
                245                 250                 255     


Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val 
            260                 265                 270         


Ile Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp Val 
        275                 280                 285             


Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val 
    290                 295                 300                 


Gly Pro Val Cys Phe Leu 
305                 310 


<210>  24
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I) with glycine-X-Y repeats, no BMP-1
       site mutation, QT version

<400>  24

Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Arg Thr 
1               5                   10                  15      


Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu Pro Gln 
        35                  40                  45              


Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg Ala Asp 
    50                  55                  60                  


Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu 
65                  70                  75                  80  


Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Ser 
                85                  90                  95      


Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser 
            100                 105                 110         


Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn 
        115                 120                 125             


Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys 
    130                 135                 140                 


Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser 
145                 150                 155                 160 


Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met Thr 
                165                 170                 175     


Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp 
            180                 185                 190         


Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser 
        195                 200                 205             


Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln 
    210                 215                 220                 


Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser Asn Glu 
225                 230                 235                 240 


Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr 
                245                 250                 255     


Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val Ile 
            260                 265                 270         


Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp Val Ala 
        275                 280                 285             


Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val Gly 
    290                 295                 300                 


Pro Val Cys Phe Leu 
305                 


<210>  25
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I) with glycine-X-Y repeats, no BMP-1
       site mutation, QT version

<400>  25

Ser Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Arg 
1               5                   10                  15      


Thr Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro Pro 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu Pro 
        35                  40                  45              


Gln Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg Ala 
    50                  55                  60                  


Asp Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr 
65                  70                  75                  80  


Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly 
                85                  90                  95      


Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His 
            100                 105                 110         


Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys 
        115                 120                 125             


Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr 
    130                 135                 140                 


Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile 
145                 150                 155                 160 


Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met 
                165                 170                 175     


Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala 
            180                 185                 190         


Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala 
        195                 200                 205             


Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp 
    210                 215                 220                 


Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser Asn 
225                 230                 235                 240 


Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val 
                245                 250                 255     


Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val 
            260                 265                 270         


Ile Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp Val 
        275                 280                 285             


Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val 
    290                 295                 300                 


Gly Pro Val Cys Phe Leu 
305                 310 


<210>  26
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), KS version

<400>  26

Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu Lys 
1               5                   10                  15      


Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Ser Arg 
            20                  25                  30          


Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser Asp 
        35                  40                  45              


Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn Leu 
    50                  55                  60                  


Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys Val 
65                  70                  75                  80  


Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser Lys 
                85                  90                  95      


Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met Thr Asp 
            100                 105                 110         


Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp Val 
        115                 120                 125             


Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser Gln 
    130                 135                 140                 


Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln Gln 
145                 150                 155                 160 


Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser Asn Glu Ile 
                165                 170                 175     


Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr Val 
            180                 185                 190         


Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val Ile Glu 
        195                 200                 205             


Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp Val Ala Pro 
    210                 215                 220                 


Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val Gly Pro 
225                 230                 235                 240 


Val Cys Phe Leu 
                


<210>  27
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), KS version

<400>  27

Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu 
1               5                   10                  15      


Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Ser 
            20                  25                  30          


Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser 
        35                  40                  45              


Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn 
    50                  55                  60                  


Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys 
65                  70                  75                  80  


Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser 
                85                  90                  95      


Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met Thr 
            100                 105                 110         


Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp 
        115                 120                 125             


Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser 
    130                 135                 140                 


Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln 
145                 150                 155                 160 


Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser Asn Glu 
                165                 170                 175     


Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr 
            180                 185                 190         


Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val Ile 
        195                 200                 205             


Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp Val Ala 
    210                 215                 220                 


Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val Gly 
225                 230                 235                 240 


Pro Val Cys Phe 
                


<210>  28
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), KS version

<400>  28

Ser Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr 
1               5                   10                  15      


Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly 
            20                  25                  30          


Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His 
        35                  40                  45              


Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys 
    50                  55                  60                  


Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr 
65                  70                  75                  80  


Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile 
                85                  90                  95      


Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met 
            100                 105                 110         


Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala 
        115                 120                 125             


Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala 
    130                 135                 140                 


Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp 
145                 150                 155                 160 


Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser Asn 
                165                 170                 175     


Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val 
            180                 185                 190         


Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val 
        195                 200                 205             


Ile Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp Val 
    210                 215                 220                 


Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val 
225                 230                 235                 240 


Gly Pro Val Cys Phe Leu 
                245     


<210>  29
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), KS version

<400>  29

Arg Ser Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr 
1               5                   10                  15      


Thr Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu 
            20                  25                  30          


Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys 
        35                  40                  45              


His Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly 
    50                  55                  60                  


Cys Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu 
65                  70                  75                  80  


Thr Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr 
                85                  90                  95      


Ile Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser 
            100                 105                 110         


Met Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro 
        115                 120                 125             


Ala Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu 
    130                 135                 140                 


Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met 
145                 150                 155                 160 


Asp Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly Ser 
                165                 170                 175     


Asn Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser 
            180                 185                 190         


Val Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr 
        195                 200                 205             


Val Ile Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile Asp 
    210                 215                 220                 


Val Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp 
225                 230                 235                 240 


Val Gly Pro Val Cys Phe Leu 
                245         


<210>  30
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), with glycine-X-Y repeats and D→N 
       mutation at BMP-1 site, QT version

<400>  30

Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Arg Thr 
1               5                   10                  15      


Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu Pro Gln 
        35                  40                  45              


Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg Ala Asn 
    50                  55                  60                  


Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu 
65                  70                  75                  80  


Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Ser 
                85                  90                  95      


Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser 
            100                 105                 110         


Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn 
        115                 120                 125             


Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys 
    130                 135                 140                 


Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser 
145                 150                 155                 160 


Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met Thr 
                165                 170                 175     


Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp 
            180                 185                 190         


Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser 
        195                 200                 205             


Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln 
    210                 215                 220                 


Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser Asn Glu 
225                 230                 235                 240 


Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr 
                245                 250                 255     


Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val Ile 
            260                 265                 270         


Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp Val Ala 
        275                 280                 285             


Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val Gly 
    290                 295                 300                 


Pro Val Cys Phe Leu 
305                 


<210>  31
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), with glycine-X-Y repeats and A→N 
       mutation at BMP-1 site, QT version

<400>  31

Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Arg Thr 
1               5                   10                  15      


Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu Pro Gln 
        35                  40                  45              


Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg Asn Asp 
    50                  55                  60                  


Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu 
65                  70                  75                  80  


Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Ser 
                85                  90                  95      


Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser 
            100                 105                 110         


Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn 
        115                 120                 125             


Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys 
    130                 135                 140                 


Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser 
145                 150                 155                 160 


Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met Thr 
                165                 170                 175     


Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp 
            180                 185                 190         


Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser 
        195                 200                 205             


Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln 
    210                 215                 220                 


Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser Asn Glu 
225                 230                 235                 240 


Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr 
                245                 250                 255     


Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val Ile 
            260                 265                 270         


Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp Val Ala 
        275                 280                 285             


Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val Gly 
    290                 295                 300                 


Pro Val Cys Phe Leu 
305                 


<210>  32
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), with glycine-X-Y repeats and D→N 
       mutation at BMP-1 site, QT version

<400>  32

Arg Ser Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly 
1               5                   10                  15      


Arg Thr Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu 
        35                  40                  45              


Pro Gln Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg 
    50                  55                  60                  


Ala Asn Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr 
65                  70                  75                  80  


Thr Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu 
                85                  90                  95      


Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys 
            100                 105                 110         


His Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly 
        115                 120                 125             


Cys Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu 
    130                 135                 140                 


Thr Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr 
145                 150                 155                 160 


Ile Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser 
                165                 170                 175     


Met Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro 
            180                 185                 190         


Ala Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu 
        195                 200                 205             


Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met 
    210                 215                 220                 


Asp Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser 
225                 230                 235                 240 


Asn Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser 
                245                 250                 255     


Val Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr 
            260                 265                 270         


Val Ile Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp 
        275                 280                 285             


Val Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp 
    290                 295                 300                 


Val Gly Pro Val Cys Phe Leu 
305                 310     


<210>  33
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), with glycine-X-Y repeats and D→N 
       mutation at BMP-1 site, QT version

<400>  33

Gly Ser Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly 
1               5                   10                  15      


Arg Thr Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe Leu 
        35                  40                  45              


Pro Gln Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr Arg 
    50                  55                  60                  


Ala Asn Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr 
65                  70                  75                  80  


Thr Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu 
                85                  90                  95      


Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys 
            100                 105                 110         


His Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly 
        115                 120                 125             


Cys Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu 
    130                 135                 140                 


Thr Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr 
145                 150                 155                 160 


Ile Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser 
                165                 170                 175     


Met Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro 
            180                 185                 190         


Ala Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu 
        195                 200                 205             


Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met 
    210                 215                 220                 


Asp Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser 
225                 230                 235                 240 


Asn Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser 
                245                 250                 255     


Val Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr 
            260                 265                 270         


Val Ile Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp 
        275                 280                 285             


Val Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp 
    290                 295                 300                 


Val Gly Pro Val Cys Phe Leu 
305                 310     


<210>  34
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type III)

<400>  34

Asp Glu Ile Met Thr Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser 
1               5                   10                  15      


Leu Ile Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg 
            20                  25                  30          


Asp Leu Lys Phe Cys His Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val 
        35                  40                  45              


Asp Pro Asn Gln Gly Cys Lys Leu Asp Ala Ile Lys Val Phe Cys Asn 
    50                  55                  60                  


Met Glu Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Leu Asn Val Pro 
65                  70                  75                  80  


Arg Lys His Trp Trp Thr Asp Ser Ser Ala Glu Lys Lys His Val Trp 
                85                  90                  95      


Phe Gly Glu Ser Met Asp Gly Gly Phe Gln Phe Ser Tyr Gly Asn Pro 
            100                 105                 110         


Glu Leu Pro Glu Asp Val Leu Asp Val Gln Leu Ala Phe Leu Arg Leu 
        115                 120                 125             


Leu Ser Ser Arg Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser 
    130                 135                 140                 


Ile Ala Tyr Met Asp Gln Ala Ser Gly Asn Val Lys Lys Ala Leu Lys 
145                 150                 155                 160 


Leu Met Gly Ser Asn Glu Gly Glu Phe Lys Ala Glu Gly Asn Ser Lys 
                165                 170                 175     


Phe Thr Tyr Thr Val Leu Glu Asp Gly Cys Thr Lys His Thr Gly Glu 
            180                 185                 190         


Trp Ser Lys Thr Val Phe Glu Tyr Arg Thr Arg Lys Ala Val Arg Leu 
        195                 200                 205             


Pro Ile Val Asp Ile Ala Pro Tyr Asp Ile Gly Gly Pro Asp Gln Glu 
    210                 215                 220                 


Phe Gly Val Asp Val Gly Pro Val Cys Phe 
225                 230                 


<210>  35
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type III)

<400>  35

Glu Pro Met Asp Phe Lys Ile Asn Thr Asp Glu Ile Met Thr Ser Leu 
1               5                   10                  15      


Lys Ser Val Asn Gly Gln Ile Glu Ser Leu Ile Ser Pro Asp Gly Ser 
            20                  25                  30          


Arg Lys Asn Pro Ala Arg Asn Cys Arg Asp Leu Lys Phe Cys His Pro 
        35                  40                  45              


Glu Leu Lys Ser Gly Glu Tyr Trp Val Asp Pro Asn Gln Gly Cys Lys 
    50                  55                  60                  


Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys 
65                  70                  75                  80  


Ile Ser Ala Asn Pro Leu Asn Val Pro Arg Lys His Trp Trp Thr Asp 
                85                  90                  95      


Ser Ser Ala Glu Lys Lys His Val Trp Phe Gly Glu Ser Met Asp Gly 
            100                 105                 110         


Gly Phe Gln Phe Ser Tyr Gly Asn Pro Glu Leu Pro Glu Asp Val Leu 
        115                 120                 125             


Asp Val Gln Leu Ala Phe Leu Arg Leu Leu Ser Ser Arg Ala Ser Gln 
    130                 135                 140                 


Asn Ile Thr Tyr His Cys Lys Asn Ser Ile Ala Tyr Met Asp Gln Ala 
145                 150                 155                 160 


Ser Gly Asn Val Lys Lys Ala Leu Lys Leu Met Gly Ser Asn Glu Gly 
                165                 170                 175     


Glu Phe Lys Ala Glu Gly Asn Ser Lys Phe Thr Tyr Thr Val Leu Glu 
            180                 185                 190         


Asp Gly Cys Thr Lys His Thr Gly Glu Trp Ser Lys Thr Val Phe Glu 
        195                 200                 205             


Tyr Arg Thr Arg Lys Ala Val Arg Leu Pro Ile Val Asp Ile Ala Pro 
    210                 215                 220                 


Tyr Asp Ile Gly Gly Pro Asp Gln Glu Phe Gly Val Asp Val Gly Pro 
225                 230                 235                 240 


Val Cys Phe Leu 
                


<210>  36
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type III)

<400>  36

Ser Glu Pro Met Asp Phe Lys Ile Asn Thr Asp Glu Ile Met Thr Ser 
1               5                   10                  15      


Leu Lys Ser Val Asn Gly Gln Ile Glu Ser Leu Ile Ser Pro Asp Gly 
            20                  25                  30          


Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg Asp Leu Lys Phe Cys His 
        35                  40                  45              


Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val Asp Pro Asn Gln Gly Cys 
    50                  55                  60                  


Lys Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr 
65                  70                  75                  80  


Cys Ile Ser Ala Asn Pro Leu Asn Val Pro Arg Lys His Trp Trp Thr 
                85                  90                  95      


Asp Ser Ser Ala Glu Lys Lys His Val Trp Phe Gly Glu Ser Met Asp 
            100                 105                 110         


Gly Gly Phe Gln Phe Ser Tyr Gly Asn Pro Glu Leu Pro Glu Asp Val 
        115                 120                 125             


Leu Asp Val Gln Leu Ala Phe Leu Arg Leu Leu Ser Ser Arg Ala Ser 
    130                 135                 140                 


Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile Ala Tyr Met Asp Gln 
145                 150                 155                 160 


Ala Ser Gly Asn Val Lys Lys Ala Leu Lys Leu Met Gly Ser Asn Glu 
                165                 170                 175     


Gly Glu Phe Lys Ala Glu Gly Asn Ser Lys Phe Thr Tyr Thr Val Leu 
            180                 185                 190         


Glu Asp Gly Cys Thr Lys His Thr Gly Glu Trp Ser Lys Thr Val Phe 
        195                 200                 205             


Glu Tyr Arg Thr Arg Lys Ala Val Arg Leu Pro Ile Val Asp Ile Ala 
    210                 215                 220                 


Pro Tyr Asp Ile Gly Gly Pro Asp Gln Glu Phe Gly Val Asp Val Gly 
225                 230                 235                 240 


Pro Val Cys Phe Leu 
                245 


<210>  37
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type III)

<400>  37

Arg Ser Glu Pro Met Asp Phe Lys Ile Asn Thr Asp Glu Ile Met Thr 
1               5                   10                  15      


Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser Leu Ile Ser Pro Asp 
            20                  25                  30          


Gly Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg Asp Leu Lys Phe Cys 
        35                  40                  45              


His Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val Asp Pro Asn Gln Gly 
    50                  55                  60                  


Cys Lys Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu 
65                  70                  75                  80  


Thr Cys Ile Ser Ala Asn Pro Leu Asn Val Pro Arg Lys His Trp Trp 
                85                  90                  95      


Thr Asp Ser Ser Ala Glu Lys Lys His Val Trp Phe Gly Glu Ser Met 
            100                 105                 110         


Asp Gly Gly Phe Gln Phe Ser Tyr Gly Asn Pro Glu Leu Pro Glu Asp 
        115                 120                 125             


Val Leu Asp Val Gln Leu Ala Phe Leu Arg Leu Leu Ser Ser Arg Ala 
    130                 135                 140                 


Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile Ala Tyr Met Asp 
145                 150                 155                 160 


Gln Ala Ser Gly Asn Val Lys Lys Ala Leu Lys Leu Met Gly Ser Asn 
                165                 170                 175     


Glu Gly Glu Phe Lys Ala Glu Gly Asn Ser Lys Phe Thr Tyr Thr Val 
            180                 185                 190         


Leu Glu Asp Gly Cys Thr Lys His Thr Gly Glu Trp Ser Lys Thr Val 
        195                 200                 205             


Phe Glu Tyr Arg Thr Arg Lys Ala Val Arg Leu Pro Ile Val Asp Ile 
    210                 215                 220                 


Ala Pro Tyr Asp Ile Gly Gly Pro Asp Gln Glu Phe Gly Val Asp Val 
225                 230                 235                 240 


Gly Pro Val Cys Phe Leu 
                245     


<210>  38
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), QT version

<400>  38

Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu Lys 
1               5                   10                  15      


Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Ser Arg 
            20                  25                  30          


Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser Asp 
        35                  40                  45              


Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn Leu 
    50                  55                  60                  


Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys Val 
65                  70                  75                  80  


Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser Lys 
                85                  90                  95      


Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met Thr Asp 
            100                 105                 110         


Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp Val 
        115                 120                 125             


Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser Gln 
    130                 135                 140                 


Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln Gln 
145                 150                 155                 160 


Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser Asn Glu Ile 
                165                 170                 175     


Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr Val 
            180                 185                 190         


Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val Ile Glu 
        195                 200                 205             


Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp Val Ala Pro 
    210                 215                 220                 


Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val Gly Pro 
225                 230                 235                 240 


Val Cys Phe Leu 
                


<210>  39
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), QT version

<400>  39

Ser Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr Thr 
1               5                   10                  15      


Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly 
            20                  25                  30          


Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys His 
        35                  40                  45              


Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys 
    50                  55                  60                  


Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu Thr 
65                  70                  75                  80  


Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile 
                85                  90                  95      


Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser Met 
            100                 105                 110         


Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala 
        115                 120                 125             


Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu Ala 
    130                 135                 140                 


Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met Asp 
145                 150                 155                 160 


Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser Asn 
                165                 170                 175     


Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val 
            180                 185                 190         


Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr Val 
        195                 200                 205             


Ile Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp Val 
    210                 215                 220                 


Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp Val 
225                 230                 235                 240 


Gly Pro Val Cys Phe Leu 
                245     


<210>  40
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), QT version

<400>  40

Arg Ser Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr 
1               5                   10                  15      


Thr Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu 
            20                  25                  30          


Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys 
        35                  40                  45              


His Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly 
    50                  55                  60                  


Cys Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu 
65                  70                  75                  80  


Thr Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr 
                85                  90                  95      


Ile Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser 
            100                 105                 110         


Met Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro 
        115                 120                 125             


Ala Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu 
    130                 135                 140                 


Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met 
145                 150                 155                 160 


Asp Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser 
                165                 170                 175     


Asn Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser 
            180                 185                 190         


Val Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr 
        195                 200                 205             


Val Ile Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp 
    210                 215                 220                 


Val Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp 
225                 230                 235                 240 


Val Gly Pro Val Cys Phe Leu 
                245         


<210>  41
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization peptide (Type I), QT version

<400>  41

Gly Ser Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp Thr 
1               5                   10                  15      


Thr Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro Glu 
            20                  25                  30          


Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met Cys 
        35                  40                  45              


His Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly 
    50                  55                  60                  


Cys Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly Glu 
65                  70                  75                  80  


Thr Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp Tyr 
                85                  90                  95      


Ile Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu Ser 
            100                 105                 110         


Met Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp Pro 
        115                 120                 125             


Ala Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr Glu 
    130                 135                 140                 


Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr Met 
145                 150                 155                 160 


Asp Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Gln Gly Ser 
                165                 170                 175     


Asn Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr Ser 
            180                 185                 190         


Val Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys Thr 
        195                 200                 205             


Val Ile Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile Asp 
    210                 215                 220                 


Val Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe Asp 
225                 230                 235                 240 


Val Gly Pro Val Cys Phe Leu 
                245         


<210>  42
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc

<400>  42

Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 


<210>  43
<211>  1628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length Endo180-Fc (D1-10-Fc)

<400>  43

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 
1               5                   10                  15      


Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Gly Ala 
            20                  25                  30          


Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Val Phe Leu Ile Phe Ser 
        35                  40                  45              


His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val Arg Val 
    50                  55                  60                  


Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys Trp Val 
65                  70                  75                  80  


Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu Gly Thr 
                85                  90                  95      


Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr Glu Cys 
            100                 105                 110         


Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu Gly Asp 
        115                 120                 125             


Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser Lys Pro 
    130                 135                 140                 


Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp Arg Ile 
145                 150                 155                 160 


Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu Val Tyr 
                165                 170                 175     


Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro Phe Lys 
            180                 185                 190         


Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp 
        195                 200                 205             


Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp Glu Arg 
    210                 215                 220                 


Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe Trp Asp 
225                 230                 235                 240 


Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln Ser Thr 
                245                 250                 255     


Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly Ala Asp 
            260                 265                 270         


Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn Gly Leu 
        275                 280                 285             


Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp Leu Asp 
    290                 295                 300                 


Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu 
305                 310                 315                 320 


Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly 
                325                 330                 335     


Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp Cys Ser 
            340                 345                 350         


Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr Ala Glu 
        355                 360                 365             


Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys Glu Pro 
    370                 375                 380                 


Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala Glu Lys 
385                 390                 395                 400 


Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp 
                405                 410                 415     


Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr Lys Gln 
            420                 425                 430         


Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp Leu Lys 
        435                 440                 445             


Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr 
    450                 455                 460                 


His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp 
465                 470                 475                 480 


Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys 
                485                 490                 495     


Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu Ser Gln 
            500                 505                 510         


Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr Trp His 
        515                 520                 525             


Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr Ser Glu 
    530                 535                 540                 


Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr Ile Thr 
545                 550                 555                 560 


Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn Trp Glu 
                565                 570                 575     


Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr Gly Ser 
            580                 585                 590         


Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp Asn Arg 
        595                 600                 605             


Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala Thr Gly 
    610                 615                 620                 


Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe Arg Ala 
625                 630                 635                 640 


Arg Tyr Ile Cys Arg Gln Ser Leu Gly Thr Pro Val Thr Pro Glu Leu 
                645                 650                 655     


Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro Gln Gly 
            660                 665                 670         


Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe Ser Ser 
        675                 680                 685             


Glu Arg Leu Gln Asp Lys Lys Ser Trp Val Gln Ala Gln Gly Ala Cys 
    690                 695                 700                 


Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu Ala Ser Tyr Glu Glu Glu 
705                 710                 715                 720 


His Phe Val Ala Asn Met Leu Asn Lys Ile Phe Gly Glu Ser Glu Pro 
                725                 730                 735     


Glu Ile His Glu Gln His Trp Phe Trp Ile Gly Leu Asn Arg Arg Asp 
            740                 745                 750         


Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser Asp Gly Val Gly Phe Ser 
        755                 760                 765             


Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp Ile Arg Gly 
    770                 775                 780                 


Cys Ala Val Leu Asp Leu Ala Ser Leu Gln Trp Val Ala Met Gln Cys 
785                 790                 795                 800 


Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile Pro Arg Gly Thr Asp Val 
                805                 810                 815     


Arg Glu Pro Asp Asp Ser Pro Gln Gly Arg Arg Glu Trp Leu Arg Phe 
            820                 825                 830         


Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp Ala Gln 
        835                 840                 845             


Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser Val His 
    850                 855                 860                 


Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys Phe Ser 
865                 870                 875                 880 


Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser Glu Ser 
                885                 890                 895     


Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe Ile Ser 
            900                 905                 910         


Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys Cys Val 
        915                 920                 925             


Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys Leu Thr 
    930                 935                 940                 


Ala Leu Pro Tyr Ile Cys Lys Arg Ser Asn Val Thr Lys Glu Thr Gln 
945                 950                 955                 960 


Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser Asp Trp 
                965                 970                 975     


Ile Gln Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu Pro Gln 
            980                 985                 990         


Ser Arg Val Lys Trp Ser Glu Ala  Gln Phe Ser Cys Glu  Gln Gln Glu 
        995                 1000                 1005             


Ala Gln  Leu Val Thr Ile Thr  Asn Pro Leu Glu Gln  Ala Phe Ile 
    1010                 1015                 1020             


Thr Ala  Ser Leu Pro Asn Val  Thr Phe Asp Leu Trp  Ile Gly Leu 
    1025                 1030                 1035             


His Ala  Ser Gln Arg Asp Phe  Gln Trp Val Glu Gln  Glu Pro Leu 
    1040                 1045                 1050             


Met Tyr  Ala Asn Trp Ala Pro  Gly Glu Pro Ser Gly  Pro Ser Pro 
    1055                 1060                 1065             


Ala Pro  Ser Gly Asn Lys Pro  Thr Ser Cys Ala Val  Val Leu His 
    1070                 1075                 1080             


Ser Pro  Ser Ala His Phe Thr  Gly Arg Trp Asp Asp  Arg Ser Cys 
    1085                 1090                 1095             


Thr Glu  Glu Thr His Gly Phe  Ile Cys Gln Lys Gly  Thr Asp Pro 
    1100                 1105                 1110             


Ser Leu  Ser Pro Ser Pro Ala  Ala Leu Pro Pro Ala  Pro Gly Thr 
    1115                 1120                 1125             


Glu Leu  Ser Tyr Leu Asn Gly  Thr Phe Arg Leu Leu  Gln Lys Pro 
    1130                 1135                 1140             


Leu Arg  Trp His Asp Ala Leu  Leu Leu Cys Glu Ser  Arg Asn Ala 
    1145                 1150                 1155             


Ser Leu  Ala Tyr Val Pro Asp  Pro Tyr Thr Gln Ala  Phe Leu Thr 
    1160                 1165                 1170             


Gln Ala  Ala Arg Gly Leu Arg  Thr Pro Leu Trp Ile  Gly Leu Ala 
    1175                 1180                 1185             


Gly Glu  Glu Gly Ser Arg Arg  Tyr Ser Trp Val Ser  Glu Glu Pro 
    1190                 1195                 1200             


Leu Asn  Tyr Val Gly Trp Gln  Asp Gly Glu Pro Gln  Gln Pro Gly 
    1205                 1210                 1215             


Gly Cys  Thr Tyr Val Asp Val  Asp Gly Ala Trp Arg  Thr Thr Ser 
    1220                 1225                 1230             


Cys Asp  Thr Lys Leu Gln Gly  Ala Val Cys Gly Val  Ser Ser Gly 
    1235                 1240                 1245             


Pro Pro  Pro Pro Arg Arg Ile  Ser Tyr His Gly Ser  Cys Pro Gln 
    1250                 1255                 1260             


Gly Leu  Ala Asp Ser Ala Trp  Ile Pro Phe Arg Glu  His Cys Tyr 
    1265                 1270                 1275             


Ser Phe  His Met Glu Leu Leu  Leu Gly His Lys Glu  Ala Arg Gln 
    1280                 1285                 1290             


Arg Cys  Gln Arg Ala Gly Gly  Ala Val Leu Ser Ile  Leu Asp Glu 
    1295                 1300                 1305             


Met Glu  Asn Val Phe Val Trp  Glu His Leu Gln Ser  Tyr Glu Gly 
    1310                 1315                 1320             


Gln Ser  Arg Gly Ala Trp Leu  Gly Met Asn Phe Asn  Pro Lys Gly 
    1325                 1330                 1335             


Gly Thr  Leu Val Trp Gln Asp  Asn Thr Ala Val Asn  Tyr Ser Asn 
    1340                 1345                 1350             


Trp Gly  Pro Pro Gly Leu Gly  Pro Ser Met Leu Ser  His Asn Ser 
    1355                 1360                 1365             


Cys Tyr  Trp Ile Gln Ser Asn  Ser Gly Leu Trp Arg  Pro Gly Ala 
    1370                 1375                 1380             


Cys Thr  Asn Ile Thr Met Gly  Val Val Cys Lys Arg  Val Glu Pro 
    1385                 1390                 1395             


Lys Ser  Cys Asp Lys Thr His  Thr Cys Pro Pro Cys  Pro Ala Pro 
    1400                 1405                 1410             


Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu Phe Pro  Pro Lys Pro 
    1415                 1420                 1425             


Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro Glu Val  Thr Cys Val 
    1430                 1435                 1440             


Val Val  Asp Val Ser His Glu  Asp Pro Glu Val Lys  Phe Asn Trp 
    1445                 1450                 1455             


Tyr Val  Asp Gly Val Glu Val  His Asn Ala Lys Thr  Lys Pro Arg 
    1460                 1465                 1470             


Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val Val Ser  Val Leu Thr 
    1475                 1480                 1485             


Val Leu  His Gln Asp Trp Leu  Asn Gly Lys Glu Tyr  Lys Cys Lys 
    1490                 1495                 1500             


Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile Glu Lys  Thr Ile Ser 
    1505                 1510                 1515             


Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln Val Tyr  Thr Leu Pro 
    1520                 1525                 1530             


Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln Val Ser  Leu Thr Cys 
    1535                 1540                 1545             


Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile Ala Val  Glu Trp Glu 
    1550                 1555                 1560             


Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys Thr Thr  Pro Pro Val 
    1565                 1570                 1575             


Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr Ser Lys  Leu Thr Val 
    1580                 1585                 1590             


Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val Phe Ser  Cys Ser Val 
    1595                 1600                 1605             


Met His  Glu Ala Leu His Asn  His Tyr Thr Gln Lys  Ser Leu Ser 
    1610                 1615                 1620             


Leu Ser  Pro Gly Lys 
    1625             


<210>  44
<211>  1598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature Endo-180-Fc(D1-10-Fc)

<400>  44

Gly Ala Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Val Phe Leu Ile 
1               5                   10                  15      


Phe Ser His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val 
            20                  25                  30          


Arg Val Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys 
        35                  40                  45              


Trp Val Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu 
    50                  55                  60                  


Gly Thr Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr 
65                  70                  75                  80  


Glu Cys Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu 
                85                  90                  95      


Gly Asp Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser 
            100                 105                 110         


Lys Pro Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp 
        115                 120                 125             


Arg Ile Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu 
    130                 135                 140                 


Val Tyr Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro 
145                 150                 155                 160 


Phe Lys Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg 
                165                 170                 175     


Glu Asp Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp 
            180                 185                 190         


Glu Arg Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe 
        195                 200                 205             


Trp Asp Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln 
    210                 215                 220                 


Ser Thr Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly 
225                 230                 235                 240 


Ala Asp Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn 
                245                 250                 255     


Gly Leu Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp 
            260                 265                 270         


Leu Asp Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys 
        275                 280                 285             


Tyr Leu Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn 
    290                 295                 300                 


Cys Gly Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp 
305                 310                 315                 320 


Cys Ser Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr 
                325                 330                 335     


Ala Glu Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys 
            340                 345                 350         


Glu Pro Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala 
        355                 360                 365             


Glu Lys Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly 
    370                 375                 380                 


Gly Asp Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr 
385                 390                 395                 400 


Lys Gln Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp 
                405                 410                 415     


Leu Lys Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser 
            420                 425                 430         


Phe Thr His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu 
        435                 440                 445             


Glu Asp Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser 
    450                 455                 460                 


Pro Cys Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu 
465                 470                 475                 480 


Ser Gln Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr 
                485                 490                 495     


Trp His Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr 
            500                 505                 510         


Ser Glu Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr 
        515                 520                 525             


Ile Thr Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn 
    530                 535                 540                 


Trp Glu Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr 
545                 550                 555                 560 


Gly Ser Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp 
                565                 570                 575     


Asn Arg Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala 
            580                 585                 590         


Thr Gly Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe 
        595                 600                 605             


Arg Ala Arg Tyr Ile Cys Arg Gln Ser Leu Gly Thr Pro Val Thr Pro 
    610                 615                 620                 


Glu Leu Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro 
625                 630                 635                 640 


Gln Gly Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe 
                645                 650                 655     


Ser Ser Glu Arg Leu Gln Asp Lys Lys Ser Trp Val Gln Ala Gln Gly 
            660                 665                 670         


Ala Cys Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu Ala Ser Tyr Glu 
        675                 680                 685             


Glu Glu His Phe Val Ala Asn Met Leu Asn Lys Ile Phe Gly Glu Ser 
    690                 695                 700                 


Glu Pro Glu Ile His Glu Gln His Trp Phe Trp Ile Gly Leu Asn Arg 
705                 710                 715                 720 


Arg Asp Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser Asp Gly Val Gly 
                725                 730                 735     


Phe Ser Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp Ile 
            740                 745                 750         


Arg Gly Cys Ala Val Leu Asp Leu Ala Ser Leu Gln Trp Val Ala Met 
        755                 760                 765             


Gln Cys Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile Pro Arg Gly Thr 
    770                 775                 780                 


Asp Val Arg Glu Pro Asp Asp Ser Pro Gln Gly Arg Arg Glu Trp Leu 
785                 790                 795                 800 


Arg Phe Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp 
                805                 810                 815     


Ala Gln Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser 
            820                 825                 830         


Val His Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys 
        835                 840                 845             


Phe Ser Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser 
    850                 855                 860                 


Glu Ser Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe 
865                 870                 875                 880 


Ile Ser Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys 
                885                 890                 895     


Cys Val Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys 
            900                 905                 910         


Leu Thr Ala Leu Pro Tyr Ile Cys Lys Arg Ser Asn Val Thr Lys Glu 
        915                 920                 925             


Thr Gln Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser 
    930                 935                 940                 


Asp Trp Ile Gln Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu 
945                 950                 955                 960 


Pro Gln Ser Arg Val Lys Trp Ser Glu Ala Gln Phe Ser Cys Glu Gln 
                965                 970                 975     


Gln Glu Ala Gln Leu Val Thr Ile Thr Asn Pro Leu Glu Gln Ala Phe 
            980                 985                 990         


Ile Thr Ala Ser Leu Pro Asn Val  Thr Phe Asp Leu Trp  Ile Gly Leu 
        995                 1000                 1005             


His Ala  Ser Gln Arg Asp Phe  Gln Trp Val Glu Gln  Glu Pro Leu 
    1010                 1015                 1020             


Met Tyr  Ala Asn Trp Ala Pro  Gly Glu Pro Ser Gly  Pro Ser Pro 
    1025                 1030                 1035             


Ala Pro  Ser Gly Asn Lys Pro  Thr Ser Cys Ala Val  Val Leu His 
    1040                 1045                 1050             


Ser Pro  Ser Ala His Phe Thr  Gly Arg Trp Asp Asp  Arg Ser Cys 
    1055                 1060                 1065             


Thr Glu  Glu Thr His Gly Phe  Ile Cys Gln Lys Gly  Thr Asp Pro 
    1070                 1075                 1080             


Ser Leu  Ser Pro Ser Pro Ala  Ala Leu Pro Pro Ala  Pro Gly Thr 
    1085                 1090                 1095             


Glu Leu  Ser Tyr Leu Asn Gly  Thr Phe Arg Leu Leu  Gln Lys Pro 
    1100                 1105                 1110             


Leu Arg  Trp His Asp Ala Leu  Leu Leu Cys Glu Ser  Arg Asn Ala 
    1115                 1120                 1125             


Ser Leu  Ala Tyr Val Pro Asp  Pro Tyr Thr Gln Ala  Phe Leu Thr 
    1130                 1135                 1140             


Gln Ala  Ala Arg Gly Leu Arg  Thr Pro Leu Trp Ile  Gly Leu Ala 
    1145                 1150                 1155             


Gly Glu  Glu Gly Ser Arg Arg  Tyr Ser Trp Val Ser  Glu Glu Pro 
    1160                 1165                 1170             


Leu Asn  Tyr Val Gly Trp Gln  Asp Gly Glu Pro Gln  Gln Pro Gly 
    1175                 1180                 1185             


Gly Cys  Thr Tyr Val Asp Val  Asp Gly Ala Trp Arg  Thr Thr Ser 
    1190                 1195                 1200             


Cys Asp  Thr Lys Leu Gln Gly  Ala Val Cys Gly Val  Ser Ser Gly 
    1205                 1210                 1215             


Pro Pro  Pro Pro Arg Arg Ile  Ser Tyr His Gly Ser  Cys Pro Gln 
    1220                 1225                 1230             


Gly Leu  Ala Asp Ser Ala Trp  Ile Pro Phe Arg Glu  His Cys Tyr 
    1235                 1240                 1245             


Ser Phe  His Met Glu Leu Leu  Leu Gly His Lys Glu  Ala Arg Gln 
    1250                 1255                 1260             


Arg Cys  Gln Arg Ala Gly Gly  Ala Val Leu Ser Ile  Leu Asp Glu 
    1265                 1270                 1275             


Met Glu  Asn Val Phe Val Trp  Glu His Leu Gln Ser  Tyr Glu Gly 
    1280                 1285                 1290             


Gln Ser  Arg Gly Ala Trp Leu  Gly Met Asn Phe Asn  Pro Lys Gly 
    1295                 1300                 1305             


Gly Thr  Leu Val Trp Gln Asp  Asn Thr Ala Val Asn  Tyr Ser Asn 
    1310                 1315                 1320             


Trp Gly  Pro Pro Gly Leu Gly  Pro Ser Met Leu Ser  His Asn Ser 
    1325                 1330                 1335             


Cys Tyr  Trp Ile Gln Ser Asn  Ser Gly Leu Trp Arg  Pro Gly Ala 
    1340                 1345                 1350             


Cys Thr  Asn Ile Thr Met Gly  Val Val Cys Lys Arg  Val Glu Pro 
    1355                 1360                 1365             


Lys Ser  Cys Asp Lys Thr His  Thr Cys Pro Pro Cys  Pro Ala Pro 
    1370                 1375                 1380             


Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu Phe Pro  Pro Lys Pro 
    1385                 1390                 1395             


Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro Glu Val  Thr Cys Val 
    1400                 1405                 1410             


Val Val  Asp Val Ser His Glu  Asp Pro Glu Val Lys  Phe Asn Trp 
    1415                 1420                 1425             


Tyr Val  Asp Gly Val Glu Val  His Asn Ala Lys Thr  Lys Pro Arg 
    1430                 1435                 1440             


Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val Val Ser  Val Leu Thr 
    1445                 1450                 1455             


Val Leu  His Gln Asp Trp Leu  Asn Gly Lys Glu Tyr  Lys Cys Lys 
    1460                 1465                 1470             


Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile Glu Lys  Thr Ile Ser 
    1475                 1480                 1485             


Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln Val Tyr  Thr Leu Pro 
    1490                 1495                 1500             


Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln Val Ser  Leu Thr Cys 
    1505                 1510                 1515             


Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile Ala Val  Glu Trp Glu 
    1520                 1525                 1530             


Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys Thr Thr  Pro Pro Val 
    1535                 1540                 1545             


Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr Ser Lys  Leu Thr Val 
    1550                 1555                 1560             


Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val Phe Ser  Cys Ser Val 
    1565                 1570                 1575             


Met His  Glu Ala Leu His Asn  His Tyr Thr Gln Lys  Ser Leu Ser 
    1580                 1585                 1590             


Leu Ser  Pro Gly Lys 
    1595             


<210>  45
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full Length D6-Fc

<400>  45

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 
1               5                   10                  15      


Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Arg Ser 
            20                  25                  30          


Pro Val Thr Pro Glu Leu Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr 
        35                  40                  45              


Gly Ser Cys Pro Gln Gly Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys 
    50                  55                  60                  


Tyr Lys Val Phe Ser Ser Glu Arg Leu Gln Asp Lys Lys Ser Trp Val 
65                  70                  75                  80  


Gln Ala Gln Gly Ala Cys Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu 
                85                  90                  95      


Ala Ser Tyr Glu Glu Glu His Phe Val Ala Asn Met Leu Asn Lys Ile 
            100                 105                 110         


Phe Gly Glu Ser Glu Pro Glu Ile His Glu Gln His Trp Phe Trp Ile 
        115                 120                 125             


Gly Leu Asn Arg Arg Asp Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser 
    130                 135                 140                 


Asp Gly Val Gly Phe Ser Tyr His Asn Phe Asp Arg Ser Arg His Asp 
145                 150                 155                 160 


Asp Asp Asp Ile Arg Gly Cys Ala Val Leu Asp Leu Ala Ser Leu Gln 
                165                 170                 175     


Trp Val Ala Met Gln Cys Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile 
            180                 185                 190         


Pro Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        195                 200                 205             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    210                 215                 220                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
225                 230                 235                 240 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                245                 250                 255     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            260                 265                 270         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        275                 280                 285             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    290                 295                 300                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
305                 310                 315                 320 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                325                 330                 335     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            340                 345                 350         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        355                 360                 365             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    370                 375                 380                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
385                 390                 395                 400 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                405                 410                 415     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425         


<210>  46
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature D6-Fc

<400>  46

Arg Ser Pro Val Thr Pro Glu Leu Pro Gly Pro Asp Pro Thr Pro Ser 
1               5                   10                  15      


Leu Thr Gly Ser Cys Pro Gln Gly Trp Ala Ser Asp Thr Lys Leu Arg 
            20                  25                  30          


Tyr Cys Tyr Lys Val Phe Ser Ser Glu Arg Leu Gln Asp Lys Lys Ser 
        35                  40                  45              


Trp Val Gln Ala Gln Gly Ala Cys Gln Glu Leu Gly Ala Gln Leu Leu 
    50                  55                  60                  


Ser Leu Ala Ser Tyr Glu Glu Glu His Phe Val Ala Asn Met Leu Asn 
65                  70                  75                  80  


Lys Ile Phe Gly Glu Ser Glu Pro Glu Ile His Glu Gln His Trp Phe 
                85                  90                  95      


Trp Ile Gly Leu Asn Arg Arg Asp Pro Arg Gly Gly Gln Ser Trp Arg 
            100                 105                 110         


Trp Ser Asp Gly Val Gly Phe Ser Tyr His Asn Phe Asp Arg Ser Arg 
        115                 120                 125             


His Asp Asp Asp Asp Ile Arg Gly Cys Ala Val Leu Asp Leu Ala Ser 
    130                 135                 140                 


Leu Gln Trp Val Ala Met Gln Cys Asp Thr Gln Leu Asp Trp Ile Cys 
145                 150                 155                 160 


Lys Ile Pro Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                165                 170                 175     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            180                 185                 190         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        195                 200                 205             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    210                 215                 220                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
225                 230                 235                 240 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                245                 250                 255     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            260                 265                 270         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        275                 280                 285             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    290                 295                 300                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
305                 310                 315                 320 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                325                 330                 335     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            340                 345                 350         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        355                 360                 365             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    370                 375                 380                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395         


