﻿                         序列表

<110>  康诺亚生物医药科技（成都）有限公司

<120>  一种含有衔接器的药物治疗剂的开发和应用

<130>  20200807

<160>  123

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  1
Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
1               5                   10                  15      
Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
            20                  25                  30          
Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
        35                  40                  45              
Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
    50                  55                  60                  
Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
65                  70                  75                  80  
Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Pro Glu Ala Ala Gly Gly 
                85                  90                  95      
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            100                 105                 110         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        115                 120                 125             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    130                 135                 140                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
145                 150                 155                 160 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                165                 170                 175     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu 
            180                 185                 190         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
        195                 200                 205             
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    210                 215                 220                 
Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
225                 230                 235                 240 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                245                 250                 255     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
            260                 265                 270         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        275                 280                 285             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    290                 295                 300                 
Gly Lys 
305     

<210>  2
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  2
Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      
Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          
Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              
Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  
Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  
Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      
Val Cys Glu Asn Cys Met Glu Met Asp Ala Pro Glu Ala Ala Gly Gly 
            100                 105                 110         
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        115                 120                 125             
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    130                 135                 140                 
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
145                 150                 155                 160 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                165                 170                 175     
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            180                 185                 190         
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu 
        195                 200                 205             
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    210                 215                 220                 
Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
225                 230                 235                 240 
Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                245                 250                 255     
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            260                 265                 270         
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        275                 280                 285             
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    290                 295                 300                 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
305                 310                 315                 320 
Gly Lys Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
                325                 330                 335     
Trp His Glu 
            

<210>  3
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  3
Gln Ser Phe Glu Glu Asn Arg Lys Leu Asn Val Tyr Asn Gln Glu Asp 
1               5                   10                  15      
Gly Ser Val Leu Leu Thr Cys His Val Lys Asn Thr Asn Ile Thr Trp 
            20                  25                  30          
Phe Lys Glu Gly Lys Met Ile Asp Ile Leu Thr Ala His Lys Asn Lys 
        35                  40                  45              
Trp Asn Leu Gly Ser Asn Thr Lys Asp Pro Arg Gly Val Tyr Gln Cys 
    50                  55                  60                  
Lys Gly Ser Lys Asp Lys Ser Lys Thr Leu Gln Val Tyr Tyr Arg Met 
65                  70                  75                  80  
Cys Gln Asn Cys Ile Glu Leu Asn Ala Pro Glu Ala Ala Gly Gly Pro 
                85                  90                  95      
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            100                 105                 110         
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        115                 120                 125             
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    130                 135                 140                 
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
145                 150                 155                 160 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                165                 170                 175     
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys 
            180                 185                 190         
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
        195                 200                 205             
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 
    210                 215                 220                 
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
225                 230                 235                 240 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                245                 250                 255     
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
            260                 265                 270         
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        275                 280                 285             
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    290                 295                 300                 
Lys 
305 

<210>  4
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  4
Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr Gln Thr Pro Tyr Gln 
1               5                   10                  15      
Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Ser Gln His Leu 
            20                  25                  30          
Gly Ser Glu Ala Gln Trp Gln His Asn Gly Lys Asn Lys Glu Asp Ser 
        35                  40                  45              
Gly Asp Arg Leu Phe Leu Pro Glu Phe Ser Glu Met Glu Gln Ser Gly 
    50                  55                  60                  
Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Asn Pro Glu Asp Ala Ser His 
65                  70                  75                  80  
His Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
                85                  90                  95      
Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            100                 105                 110         
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        115                 120                 125             
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    130                 135                 140                 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
145                 150                 155                 160 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                165                 170                 175     
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            180                 185                 190         
Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        195                 200                 205             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
    210                 215                 220                 
Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
225                 230                 235                 240 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                245                 250                 255     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            260                 265                 270         
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        275                 280                 285             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    290                 295                 300                 
Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Leu Asn Asp Ile 
305                 310                 315                 320 
Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
                325                 330 

<210>  5
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  5
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210>  6
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  6
caggctgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgaccctg        60
acctgtagat cttctacagg cgccgtgacc accagcaact acgctaattg ggtgcagcag       120
aagcccggcc aggctcctag aggactgatc ggcggaacaa acaagagagc cccttggaca       180
cccgccagat tctctggatc tctgctcggc ggaaaggccg ctctgacact ttctggtgct       240
cagcctgagg acgaggccga gtactattgt gccctgtggt acagcaacct gtgggtgttc       300
ggcggaggca ccaaactgac agttctg                                           327

<210>  7
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  7
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  

<210>  8
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  8
Gly Gly Thr Asn Lys Arg Ala Pro 
1               5               

<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   

<210>  10
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  10
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210>  11
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  11
caggctgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgaccctg        60
acctgtagat cttctacagg cgccgtgacc accagcaact acgctaattg ggtgcaggag       120
aagcccggcc aggctcctag aggactgatc ggcggaacaa acaagagagc cccttggaca       180
cccgccagat tctctggatc tctgctcggc ggaaaggccg ctctgacact ttctggtgct       240
cagcctgagg acgaggccga gtactattgt gccctgtggt acagcaacct gtgggtgttc       300
ggcggaggca ccaaactgac agttctg                                           327

<210>  12
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  12
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Glu Ser Ser Asp Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Glu Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210>  13
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  13
gaggctgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgaccctg        60
acctgtgagt cttctgacgg cgccgtgacc accagcaact acgctaattg ggtgcaggag       120
aagcccggcc aggctcctag aggactgatc ggcggaacaa acaaggaggc cccttggaca       180
cccgccagat tctctggatc tctgctcggc ggaaaggccg ctctgacact ttctggtgct       240
cagcctgagg acgaggccga gtactattgt gccctgtggt acagcaacct gtgggtgttc       300
ggcggaggca ccaaactgac agttctg                                           327

<210>  14
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  14
Glu Ser Ser Asp Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  

<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  15
Gly Gly Thr Asn Lys Glu Ala Pro 
1               5               

<210>  16
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  16
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Glu Ser Ser Asp Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Glu Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210>  17
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  17
caggctgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgaccctg        60
acctgtgagt cttctgacgg cgccgtgacc accagcaact acgctaattg ggtgcaggag       120
aagcccggcc aggctcctag aggactgatc ggcggaacaa acaaggaggc cccttggaca       180
cccgccagat tctctggatc tctgctcggc ggaaaggccg ctctgacact ttctggtgct       240
cagcctgagg acgaggccga gtactattgt gccctgtggt acagcaacct gtgggtgttc       300
ggcggaggca ccaaactgac agttctg                                           327

<210>  18
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  18
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210>  19
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  19
caggctgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgaccctg        60
acctgtagat cttctacagg cgccgtgacc accagcaact acgctaattg ggtgcaggag       120
aagcccggcc aggctcctag aggactgatc ggcggaacaa acaagagagc cccttggaca       180
cccgccagat tctctggatc tctgctcggc ggaaaggccg ctctgacaat cactggtgct       240
caggctgagg acgaggccga gtactattgt gtgctgtggt acagcaacct gtgggtgttc       300
ggcggaggca ccaaactgac agttctg                                           327

<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20
Tyr Gly Thr Asn Lys Arg Ala Pro 
1               5               

<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   

<210>  22
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  22
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Phe Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Tyr Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210>  23
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  23
caggctgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgaccctg        60
acctgtagat cttctacagg cgccgtgacc accagcaact acgctaattg gttccaggag       120
aagcccggcc aggctcctag aggactgatc tacggaacaa acaagagagc cccttggaca       180
cccgccagat tctctggatc tctgctcggc ggaaaggccg ctctgacact ttctggtgct       240
caggctgagg acgaggccga gtactattgt gtcctgtggt acagcaacct gtgggtgttc       300
ggcggaggca ccaaactgac agttctg                                           327

<210>  24
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  25
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  25
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttcaac acctacgcta tgaactgggt ccgacaggcc       120
cctggcaaag gactggaatg ggtgtccaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacacc       240
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  26
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  26
Asn Thr Tyr Ala Met Asn 
1               5       

<210>  27
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  27
Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      
Lys Asp 
        

<210>  28
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  28
His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  

<210>  29
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  30
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  30
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttctcc acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgtccaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacacc       240
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  31
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  31
Ser Thr Tyr Ala Met Asn 
1               5       

<210>  32
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Glu Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  33
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  33
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttctcc acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgtccaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacacc       240
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcgagag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  34
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  34
His Gly Asn Phe Gly Glu Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  

<210>  35
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Gln Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  36
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  36
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttctcc acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgtccaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacacc       240
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggccagag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  37
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  37
His Gly Asn Phe Gly Gln Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  

<210>  38
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asp Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  39
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  39
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttctcc acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgtccaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacacc       240
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcgacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  40
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  40
His Gly Asn Phe Gly Asp Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  

<210>  41
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Thr Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  42
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  42
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttctcc acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgtccaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacacc       240
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcaccag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  43
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  43
His Gly Asn Phe Gly Thr Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  

<210>  44
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Glu Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  45
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  45
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttctcc gactacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgtccaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgga ggacagattc accatcagca gggacgacag caagaacacc       240
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  46
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  46
Ser Asp Tyr Ala Met Asn 
1               5       

<210>  47
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  47
Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      
Glu Asp 
        

<210>  48
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  49
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  49
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttcaac acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgggaaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacagc       240
ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgtgccaga       300
cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  50
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  50
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  51
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  51
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttcaac acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgggaaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacagc       240
ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  52
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  52
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  53
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  53
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttcaac acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtggccaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacagc       240
ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctct                                                        375

<210>  54
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  54
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210>  55
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  55
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagccaca        60
ctgagctgta gagccagcag cagcgtgtcc tacatccact ggttccagca gaagcctgga       120
caggccccta gacctctgat ctacgccaca agcaacctgg ccagcggcat ccctgataga       180
ttcagcggct ctggcagcgg caccgactac acactgacaa tcagcagact ggaacccgag       240
gacttcgccg tgtactactg ccagcagtgg accagcaatc ctcctacatt cggccagggc       300
accaagctgg aaatcaag                                                     318

<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56
Arg Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  

<210>  57
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  57
Ala Thr Ser Asn Leu Ala Ser 
1               5           

<210>  58
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  58
Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   

<210>  59
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  59
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  60
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  60
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagccaca        60
ctgagctgta gagccagcca gagcgtgtcc tcttacctgg cctggtatca gcagaagcct       120
ggacaggctc ccagactgct gatctacgac gccagcaaca gagccacagg catccccgat       180
agattcagcg gctctggctc tggcaccgac ttcaccctga caatcagcag actggaaccc       240
gaggacttcg ccgtgtacta ctgccagcag agaagcaact ggcccatcac attcggccag       300
ggcaccaagc tggaaatcaa g                                                 321

<210>  61
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  61
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210>  62
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  62
Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210>  63
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  63
Gln Gln Arg Ser Asn Trp Pro Ile Thr 
1               5                   

<210>  64
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  64
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210>  65
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  65
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg        60
tcctgcaagg ctagcggcta cacattcacc agctacaaca tgcactgggt ccgacaggcc       120
cctggacagg gacttgaatg gatgggcgct atctaccctg gcaacggcga cacctcctac       180
aaccagaaat tccagggcag agtgaccctg accgccgaca agtctagcag caccgcctac       240
atggaactga gcagcctgag aagcgaggac accgccgtgt actactgtgc cagaagcacc       300
tactacggcg gcgactggta cttcaacgtg tggggacagg gaaccctggt caccgtttct       360
tct                                                                     363

<210>  66
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  66
Ser Tyr Asn Met His 
1               5   

<210>  67
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  67
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210>  68
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  68
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10          

<210>  69
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  69
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210>  70
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  70
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg        60
tcctgcaagg ctagcggcta cacattcacc agctacaaca tgcactgggt ccgacaggcc       120
cctggacagg gacttgaatg gatgggcgct atctaccctg gcaacggcga cacctcctac       180
aaccagaaat tccagggcag agtgaccctg accgccgaca agtctagcag caccgcctac       240
atggaactga gcagcctgag aagcgaggac accgccgtgt actactgtgc cagaagcacc       300
tactacggcg gcgactggta cttcgactat tggggacagg gaaccctggt caccgtttct       360
tct                                                                     363

<210>  71
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  71
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Tyr 
1               5                   10          

<210>  72
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  72
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210>  73
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  73
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggcta caccttcacc agctacaata tgcactgggt ccgacaggcc       120
cctggacagg gacttgaatg gatgggcgct atctaccctg gcaacggcga cacctcctac       180
aaccagaaat tccagggcag agtgaccctg accgccgaca agtctagcag caccgcctac       240
atggaactga gcagcctgag aagcgaggac accgccgtgt actactgtgc cagaagcacc       300
tactacggcg gcgactggta cttcaacgtg tggggacagg gaaccctggt caccgtttct       360
tct                                                                     363

<210>  74
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  74
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>  75
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  75
gaagtgcagc tgctggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg        60
tcttgtgccg cttctggctt caccttcaac gactacgcca tgcactgggt ccgacaggcc       120
cctggaaaag gactggaatg ggtgtccacc atcagctgga acagcggctc tatcggctac       180
gccgattccg tgaagggcag attcaccatc tccagagaca acgccaagaa aaccctgtac       240
ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc caaggacatc       300
cagtacggca actactacta cggcatggac gtgtggggcc agggaacact ggttaccgtt       360
agctct                                                                  366

<210>  76
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  76
Asp Tyr Ala Met His 
1               5   

<210>  77
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  77
Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  78
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  78
Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              

<210>  79
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  79
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>  80
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  80
gaagtgcagc tgctggaatc tggtggcgga ctggttcagc ctggcggctc tctgagactg        60
tcttgtgctg ccagcggctt caccttcaac gactacgcta tgcactgggt ccgacaggcc       120
cctggcaaag gacttgaatg ggtgtccacc atcagctgga acagcggctc tatcggctac       180
gccgattccg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac       240
ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc caaggacatc       300
cagtacggca actactacta cggcatggac gtgtggggcc agggaacact ggttaccgtt       360
agctct                                                                  366

<210>  81
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  81
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>  82
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  82
gaagtgcagc tgctggaatc tggtggcgga gttgttcagc ctggcggctc tctgagactg        60
tcttgtgctg ccagcggctt caccttcaac gactacgcta tgcactgggt ccgacaggcc       120
cctggcaaag gacttgaatg ggtgtccacc atcagctgga acagcggctc tatcggctac       180
gccgattccg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac       240
ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc caaggacatc       300
cagtacggca actactacta cggcatggac gtgtggggcc agggaacact ggttaccgtt       360
agctct                                                                  366

<210>  83
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  83
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>  84
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  84
gaagtgcagc tgctggaatc tggtggcgga gttgttcagc ctggcggctc tctgagactg        60
tcttgtgctg ccagcggctt caccttcaac gactacgcta tgcactgggt ccgacaggcc       120
cctggcaaag gacttgaatg ggtgtccacc atcagctgga acagcggctc tatcggctac       180
gccgattccg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac       240
ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc caaggacatc       300
cagtacggca actactacta cggcatggac tactggggcc agggaacact ggttaccgtt       360
agctct                                                                  366

<210>  85
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  85
Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Tyr 
1               5                   10              

<210>  86
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  86
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Asn Met His Trp Val Arg Glu Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Glu Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 
Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         
Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             
Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             

<210>  87
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  87
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg        60
tcctgcaagg ctagcggcta cacattcacc agctacaaca tgcactgggt ccgagaggcc       120
cctggacagg gacttgaatg gatgggcgct atctaccctg gcaacggcga cacctcctac       180
aaccagaaat tccagggcag agtgaccctg accgccgaca agtctagcag caccgcctac       240
atggaactga gcagcctgag aagcgaggac accgccgtgt actactgtgc cagaagcacc       300
tactacggcg gcgactggta cttcgactat tggggacagg gaaccctggt caccgtttct       360
tctgctagca ccaagggccc cagcgtgttc cccctggccc cttgcagcag aagcaccagc       420
gagagcacag ccgccctggg ctgcctggtg gaggactact tccccgagcc cgtgaccgtg       480
tcctggaaca gcggcgctct gaccagcggc gtgcatacct tccccgccgt gctccagagc       540
agcggactgt actccctgag cagcgtggtg accgtgcctt ccagcagcct gggcaccaag       600
acctacacct gcaacgtgga ccacaagccc agcaacacca aggtggacga gagagtggag       660
agcaagtacg gccctccctg ccccccttgc cctgcccccg agttcgaagg cggacctagc       720
gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcagaac ccccgaggtg       780
acctgcgtgg tggtggacgt gtcccaggag gaccccgagg tccagtttaa ttggtacgtg       840
gacggcgtgg aagtgcataa cgccaagacc aagcccagag aggagcagtt cgccagcacc       900
tacagagtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaggaatac       960
aagtgcaagg tctccaacaa gggcctgcct agcagcatcg agaagaccat cagcaaggcc      1020
aagggccagc cacgggagcc ccaggtctgc accctgccac ctagccaaga ggagatgacc      1080
aagaaccagg tgtccctgag ctgtgccgtg aaaggcttct atcccagcga tatcgccgtg      1140
gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc tgtgctggac      1200
agcgacggca gcttcttcct ggtttccaag ctgaccgtgg acaagtccag atggcaggag      1260
ggcaacgtct tcagctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag      1320
tccctgagcc tgagcctggg caag                                             1344

<210>  88
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  88
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Lys Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Lys Lys Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys 
    210             

<210>  89
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  89
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagccaca        60
ctgagctgta gagccagcag cagcgtgtcc tacatccact ggttccagaa gaagcctgga       120
caggccccta gacctctgat ctacgccaca agcaacctgg ccagcggcat ccctgataga       180
ttcagcggct ctggcagcgg caccgactac acactgacaa tcagcagact ggaacccgag       240
gacttcgccg tgtactactg ccagcagtgg accagcaatc ctcctacatt cggccagggc       300
accaagctgg aaatcaagcg aactgtggct gcaccatctg tcttcatctt cccgccatct       360
gataagaaat tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc       420
agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag       480
agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg       540
agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg       600
agctcgcccg tcacaaagag cttcaacagg ggagagtgt                              639

<210>  90
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  90
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Thr Glu Cys Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 
Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Gln 
            340                 345                 350         
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 

<210>  91
<211>  1332
<212>  DNA
<213>  Homo sapiens

<400>  91
caggctgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgaccctg        60
acctgtagat cttctacagg cgccgtgacc accagcaact acgctaattg ggtgcaggag       120
aagcccggcc aggctcctag aggactgatc ggcggaacaa acaagagagc cccttggaca       180
cccgccagat tctctggatc tctgctcggc ggaaaggccg ctctgacaat cactggtgct       240
caggctgagg acgaggccga gtactattgt gtgctgtggt acagcaacct gtgggtgttc       300
ggcggaggca ccaaactgac agttctgggt cagcccaagg cggcgccctc ggtcactctg       360
ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt       420
gacttctatc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg       480
ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctac       540
ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat       600
gaagggagca ccgtggagaa gacagtggcc cctacagaat gttcagagag caagtacggc       660
cctccctgcc ccccttgccc tgcccccgag ttcgagggcg gacctagcgt gttcctgttc       720
ccccccaagc ccaaggacac cctgatgatc agcagaaccc ccgaggtgac ctgcgtggtg       780
gtggacgtgt cccaggagga ccccgaggtc cagtttaatt ggtacgtgga cggcgtggaa       840
gtgcataacg ccaagaccaa gcccagagag gagcagttcg ccagcaccta cagagtggtg       900
tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aggaatacaa gtgcaaggtc       960
tccaacaagg gcctgcctag cagcatcgag aagaccatca gcaaggccaa gggccagcca      1020
cgggagcccc aggtctacac cctgccacct tgtcaagagg agatgaccaa gaaccaggtg      1080
tccctgtggt gtctggtgaa aggcttctat cccagcgata tcgccgtgga gtgggagagc      1140
aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggcagc      1200
ttcttcctgt actccaagct gaccgtggac aagtccagat ggcaggaggg caacgtcttc      1260
agctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg      1320
agcctgggca ag                                                          1332

<210>  92
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  92
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 
Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             
Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220             

<210>  93
<211>  669
<212>  DNA
<213>  Homo sapiens

<400>  93
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttcaac acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgggaaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacagc       240
ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctctgctag caccaagggc cccagcgtgt tccccctggc cccttgcagc       420
agaagcacca gcgagagcac agccgccctg ggctgcctgg tgaaggacta cttccccgag       480
cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gcgtgcatac cttccccgcc       540
gtgctccaga gcagcggact gtactccctg agcagcgtgg tgaccgtgcc ttccagcagc       600
ctgggcacca agacctacac ctgcaacgtg gaccacaagc ccagcaacac caaggtggac       660
aagagagtg                                                               669

<210>  94
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  94
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Glu Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             
Lys 
    

<210>  95
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  95
gaagtgcagc tgctggaatc tggtggcgga ctggttcagc ctggcggctc tctgagactg        60
tcttgtgctg ccagcggctt caccttcaac gactacgcta tgcactgggt ccgagaggcc       120
cctggcaaag gacttgaatg ggtgtccacc atcagctgga acagcggctc tatcggctac       180
gccgattccg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac       240
ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc caaggacatc       300
cagtacggca actactacta cggcatggac gtgtggggcc agggaacact ggttaccgtt       360
agctctgcta gcaccaaggg ccccagcgtg ttccccctgg ccccttgcag cagaagcacc       420
agcgagagca cagccgccct gggctgcctg gtggaggact acttccccga gcccgtgacc       480
gtgtcctgga acagcggcgc tctgaccagc ggcgtgcata ccttccccgc cgtgctccag       540
agcagcggac tgtactccct gagcagcgtg gtgaccgtgc cttccagcag cctgggcacc       600
aagacctaca cctgcaacgt ggaccacaag cccagcaaca ccaaggtgga cgagagagtg       660
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcga aggcggacct       720
agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag       780
gtgacctgcg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt taattggtac       840
gtggacggcg tggaagtgca taacgccaag accaagccca gagaggagca gttcgccagc       900
acctacagag tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa       960
tacaagtgca aggtctccaa caagggcctg cctagcagca tcgagaagac catcagcaag      1020
gccaagggcc agccacggga gccccaggtc tgcaccctgc cacctagcca agaggagatg      1080
accaagaacc aggtgtccct gagctgtgcc gtgaaaggct tctatcccag cgatatcgcc      1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      1200
gacagcgacg gcagcttctt cctggtttcc aagctgaccg tggacaagtc cagatggcag      1260
gagggcaacg tcttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      1320
aagtccctga gcctgagcct gggcaag                                          1347

<210>  96
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  96
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Lys Lys Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  97
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  97
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagccaca        60
ctgagctgta gagccagcca gagcgtgtcc tcttacctgg cctggtatca gaagaagcct       120
ggacaggctc ccagactgct gatctacgac gccagcaaca gagccacagg catccccgat       180
agattcagcg gctctggctc tggcaccgac ttcaccctga caatcagcag actggaaccc       240
gaggacttcg ccgtgtacta ctgccagcag agaagcaact ggcccatcac attcggccag       300
ggcaccaagc tggaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca       360
tctgataaga aattgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat       420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag       480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg       540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc       600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                          642

<210>  98
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  98
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Glu Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             
Lys 
    

<210>  99
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  99
gaagtgcagc tgctggaatc tggtggcgga gttgttcagc ctggcggctc tctgagactg        60
tcttgtgctg ccagcggctt caccttcaac gactacgcta tgcactgggt ccgagaggcc       120
cctggcaaag gacttgaatg ggtgtccacc atcagctgga acagcggctc tatcggctac       180
gccgattccg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac       240
ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc caaggacatc       300
cagtacggca actactacta cggcatggac tactggggcc agggaacact ggttaccgtt       360
agctctgcta gcaccaaggg ccccagcgtg ttccccctgg ccccttgcag cagaagcacc       420
agcgagagca cagccgccct gggctgcctg gtggaggact acttccccga gcccgtgacc       480
gtgtcctgga acagcggcgc tctgaccagc ggcgtgcata ccttccccgc cgtgctccag       540
agcagcggac tgtactccct gagcagcgtg gtgaccgtgc cttccagcag cctgggcacc       600
aagacctaca cctgcaacgt ggaccacaag cccagcaaca ccaaggtgga cgagagagtg       660
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcga aggcggacct       720
agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag       780
gtgacctgcg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt taattggtac       840
gtggacggcg tggaagtgca taacgccaag accaagccca gagaggagca gttcgccagc       900
acctacagag tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa       960
tacaagtgca aggtctccaa caagggcctg cctagcagca tcgagaagac catcagcaag      1020
gccaagggcc agccacggga gccccaggtc tgcaccctgc cacctagcca agaggagatg      1080
accaagaacc aggtgtccct gagctgtgcc gtgaaaggct tctatcccag cgatatcgcc      1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      1200
gacagcgacg gcagcttctt cctggtttcc aagctgaccg tggacaagtc cagatggcag      1260
gagggcaacg tcttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      1320
aagtccctga gcctgagcct gggcaag                                          1347

<210>  100
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  100
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Lys Lys Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  101
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  101
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagccaca        60
ctgagctgta gagccagcca gagcgtgtcc tcttacctgg cctggtatca gaagaagcct       120
ggacaggctc ccagactgct gatctacgac gccagcaaca gagccacagg catccccgat       180
agattcagcg gctctggctc tggcaccgac ttcaccctga caatcagcag actggaaccc       240
gaggacttcg ccgtgtacta ctgccagcag agaagcaact ggcccatcac attcggccag       300
ggcaccaagc tggaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca       360
tctgataaga aattgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat       420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag       480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg       540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc       600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                          642

<210>  102
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  102
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  103
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  103
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagccaca        60
ctgagctgta gagccagcca gagcgtgtcc tcttacctgg cctggtatca gcagaagcct       120
ggacaggctc ccagactgct gatctacgac gccagcaaca gagccacagg catccccgat       180
agattcagcg gctctggctc tggcaccgac ttcaccctga caatcagcag actggaaccc       240
gaggacttcg ccgtgtacta ctgccagcag agaagcaact ggcccatcac attcggccag       300
ggcaccaagc tggaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca       360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat       420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag       480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg       540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc       600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                          642

<210>  104
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  104
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Ala Ser Ser Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             
Lys 
    

<210>  105
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  105
gaagtgcagc tgctggaatc tggtggcgga gttgttcagc ctggcggctc tctgagactg        60
tcttgtgctg ccagcggctt caccttcaac gactacgcta tgcactgggt ccgacaggcc       120
cctggcaaag gacttgaatg ggtgtccacc atcagctgga acagcggctc tatcggctac       180
gccgattccg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac       240
ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc caaggacatc       300
cagtacggca actactacta cggcatggac tactggggcc agggaacact ggttaccgtt       360
agctctgcta gcaccaaggg ccccagcgtg ttccccctgg ccccttgcag cagaagcacc       420
agcgagagca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc       480
gtgtcctgga acagcggcgc tctgaccagc ggcgtgcata ccttccccgc cgtgctccag       540
agcagcggac tgtactccct gagcagcgtg gtgaccgtgc cttccagcag cctgggcacc       600
aagacctaca cctgcaacgt ggaccacaag cccagcaaca ccaaggtgga caagagagtg       660
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcga gggcggacct       720
agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag       780
gtgacctgcg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt taattggtac       840
gtggacggcg tggaagtgca taacgccaag accaagccca gagaggagca gttcaacagc       900
acctacagag tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa       960
tacaagtgca aggtctccaa caagggcctg gccagcagca tcgagaagac catcagcaag      1020
gccaagggcc agccacggga gccccaggtc tgcaccctgc cacctagcca agaggagatg      1080
accaagaacc aggtgtccct gagctgtgcc gtgaaaggct tctatcccag cgatatcgcc      1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      1200
gacagcgacg gcagcttctt cctggtttcc aagctgaccg tggacaagtc cagatggcag      1260
gagggcaacg tcttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      1320
aagtccctga gcctgagcct gggcaag                                          1347

<210>  106
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  106
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Thr Glu Cys Ser 
    210                 215 

<210>  107
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  107
caggctgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgaccctg        60
acctgtagat cttctacagg cgccgtgacc accagcaact acgctaattg ggtgcagcag       120
aagcccggcc aggctcctag aggactgatc ggcggaacaa acaagagagc cccttggaca       180
cccgccagat tctctggatc tctgctcggc ggaaaggccg ctctgacaat cactggtgct       240
caggctgagg acgaggccga gtactattgt gtgctgtggt acagcaacct gtgggtgttc       300
ggcggaggca ccaaactgac agttctgggt cagcccaagg cggcgccctc ggtcactctg       360
ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt       420
gacttctatc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg       480
ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctac       540
ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat       600
gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                       645

<210>  108
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  108
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 
Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             
Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Ala Ser Ser 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Cys Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Leu Gly Lys 
    450         

<210>  109
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  109
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttcaac acctacgcta tgaactgggt ccgacaggcc       120
cctggcaaag gactggaatg ggtgggaaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacagc       240
ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctctgctag caccaagggc cccagcgtgt tccccctggc cccttgcagc       420
agaagcacca gcgagagcac agccgccctg ggctgcctgg tgaaggacta cttccccgag       480
cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gcgtgcatac cttccccgcc       540
gtgctccaga gcagcggact gtactccctg agcagcgtgg tgaccgtgcc ttccagcagc       600
ctgggcacca agacctacac ctgcaacgtg gaccacaagc ccagcaacac caaggtggac       660
aagagagtgg agagcaagta cggccctccc tgcccccctt gccctgcccc cgagttcgag       720
ggcggaccta gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcaga       780
acccccgagg tgacctgcgt ggtggtggac gtgtcccagg aggaccccga ggtccagttt       840
aattggtacg tggacggcgt ggaagtgcat aacgccaaga ccaagcccag agaggagcag       900
ttcaacagca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac       960
ggcaaggaat acaagtgcaa ggtctccaac aagggcctgg ccagcagcat cgagaagacc      1020
atcagcaagg ccaagggcca gccacgggag ccccaggtct acaccctgcc accttgtcaa      1080
gaggagatga ccaagaacca ggtgtccctg tggtgtctgg tgaaaggctt ctatcccagc      1140
gatatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc      1200
cctgtgctgg acagcgacgg cagcttcttc ctgtactcca agctgaccgt ggacaagtcc      1260
agatggcagg agggcaacgt cttcagctgc tccgtgatgc acgaggccct gcacaaccac      1320
tacacccaga agtccctgag cctgagcctg ggcaag                                1356

<210>  110
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  110
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  111
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  111
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagccaca        60
ctgagctgta gagccagcca gagcgtgtcc tcttacctgg cctggtatca gaagaagcct       120
ggacaggctc ccagactgct gatctacgac gccagcaaca gagccacagg catccccgat       180
agattcagcg gctctggctc tggcaccgac ttcaccctga caatcagcag actggaaccc       240
gaggacttcg ccgtgtacta ctgccagcag agaagcaact ggcccatcac attcggccag       300
ggcaccaagc tggaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca       360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat       420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag       480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg       540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc       600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                          642

<210>  112
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  112
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Ala Ser Ser Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             
Lys 
    

<210>  113
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  113
gaagtgcagc tgctggaatc tggtggcgga gttgttcagc ctggcggctc tctgagactg        60
tcttgtgctg ccagcggctt caccttcaac gactacgcta tgcactgggt ccgagaggcc       120
cctggcaaag gacttgaatg ggtgtccacc atcagctgga acagcggctc tatcggctac       180
gccgattccg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac       240
ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc caaggacatc       300
cagtacggca actactacta cggcatggac tactggggcc agggaacact ggttaccgtt       360
agctctgcta gcaccaaggg ccccagcgtg ttccccctgg ccccttgcag cagaagcacc       420
agcgagagca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc       480
gtgtcctgga acagcggcgc tctgaccagc ggcgtgcata ccttccccgc cgtgctccag       540
agcagcggac tgtactccct gagcagcgtg gtgaccgtgc cttccagcag cctgggcacc       600
aagacctaca cctgcaacgt ggaccacaag cccagcaaca ccaaggtgga caagagagtg       660
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcga gggcggacct       720
agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag       780
gtgacctgcg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt taattggtac       840
gtggacggcg tggaagtgca taacgccaag accaagccca gagaggagca gttcaacagc       900
acctacagag tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa       960
tacaagtgca aggtctccaa caagggcctg gccagcagca tcgagaagac catcagcaag      1020
gccaagggcc agccacggga gccccaggtc tgcaccctgc cacctagcca agaggagatg      1080
accaagaacc aggtgtccct gagctgtgcc gtgaaaggct tctatcccag cgatatcgcc      1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      1200
gacagcgacg gcagcttctt cctggtttcc aagctgaccg tggacaagtc cagatggcag      1260
gagggcaacg tcttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      1320
aagtccctga gcctgagcct gggcaag                                          1347

<210>  114
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  114
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Thr Glu Cys Ser 
    210                 215 

<210>  115
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  115
caggctgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgaccctg        60
acctgtagat cttctacagg cgccgtgacc accagcaact acgctaattg ggtgcaggag       120
aagcccggcc aggctcctag aggactgatc ggcggaacaa acaagagagc cccttggaca       180
cccgccagat tctctggatc tctgctcggc ggaaaggccg ctctgacaat cactggtgct       240
caggctgagg acgaggccga gtactattgt gtgctgtggt acagcaacct gtgggtgttc       300
ggcggaggca ccaaactgac agttctgggt cagcccaagg cggcgccctc ggtcactctg       360
ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt       420
gacttctatc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg       480
ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctac       540
ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat       600
gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                       645

<210>  116
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  116
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 
Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             
Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Ala Ser Ser 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Cys Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Leu Gly Lys 
    450         

<210>  117
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  117
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg        60
tcttgtgccg ccagcggctt caccttcaac acctacgcta tgaactgggt ccgaaaggcc       120
cctggcaaag gactggaatg ggtgggaaga atcaggtcca agtacaacaa ctacgccacc       180
tactacgccg acagcgtgaa ggacagattc accatcagca gggacgacag caagaacagc       240
ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgtgtcaga       300
cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcacactg       360
gtcacagtta gctctgctag caccaagggc cccagcgtgt tccccctggc cccttgcagc       420
agaagcacca gcgagagcac agccgccctg ggctgcctgg tgaaggacta cttccccgag       480
cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gcgtgcatac cttccccgcc       540
gtgctccaga gcagcggact gtactccctg agcagcgtgg tgaccgtgcc ttccagcagc       600
ctgggcacca agacctacac ctgcaacgtg gaccacaagc ccagcaacac caaggtggac       660
aagagagtgg agagcaagta cggccctccc tgcccccctt gccctgcccc cgagttcgag       720
ggcggaccta gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcaga       780
acccccgagg tgacctgcgt ggtggtggac gtgtcccagg aggaccccga ggtccagttt       840
aattggtacg tggacggcgt ggaagtgcat aacgccaaga ccaagcccag agaggagcag       900
ttcaacagca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac       960
ggcaaggaat acaagtgcaa ggtctccaac aagggcctgg ccagcagcat cgagaagacc      1020
atcagcaagg ccaagggcca gccacgggag ccccaggtct acaccctgcc accttgtcaa      1080
gaggagatga ccaagaacca ggtgtccctg tggtgtctgg tgaaaggctt ctatcccagc      1140
gatatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc      1200
cctgtgctgg acagcgacgg cagcttcttc ctgtactcca agctgaccgt ggacaagtcc      1260
agatggcagg agggcaacgt cttcagctgc tccgtgatgc acgaggccct gcacaaccac      1320
tacacccaga agtccctgag cctgagcctg ggcaag                                1356

<210>  118
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  118
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Lys Lys Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  119
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  119
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagccaca        60
ctgagctgta gagccagcca gagcgtgtcc tcttacctgg cctggtatca gaagaagcct       120
ggacaggctc ccagactgct gatctacgac gccagcaaca gagccacagg catccccgat       180
agattcagcg gctctggctc tggcaccgac ttcaccctga caatcagcag actggaaccc       240
gaggacttcg ccgtgtacta ctgccagcag agaagcaact ggcccatcac attcggccag       300
ggcaccaagc tggaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca       360
tctgataaga aattgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat       420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag       480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg       540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc       600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                          642

<210>  120
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  120
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Glu Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Ala Ser Ser Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             
Lys 
    

<210>  121
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  121
gaagtgcagc tgctggaatc tggtggcgga gttgttcagc ctggcggctc tctgagactg        60
tcttgtgctg ccagcggctt caccttcaac gactacgcta tgcactgggt ccgagaggcc       120
cctggcaaag gacttgaatg ggtgtccacc atcagctgga acagcggctc tatcggctac       180
gccgattccg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac       240
ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc caaggacatc       300
cagtacggca actactacta cggcatggac tactggggcc agggaacact ggttaccgtt       360
agctctgcta gcaccaaggg ccccagcgtg ttccccctgg ccccttgcag cagaagcacc       420
agcgagagca cagccgccct gggctgcctg gtggaggact acttccccga gcccgtgacc       480
gtgtcctgga acagcggcgc tctgaccagc ggcgtgcata ccttccccgc cgtgctccag       540
agcagcggac tgtactccct gagcagcgtg gtgaccgtgc cttccagcag cctgggcacc       600
aagacctaca cctgcaacgt ggaccacaag cccagcaaca ccaaggtgga cgagagagtg       660
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcga aggcggacct       720
agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag       780
gtgacctgcg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt taattggtac       840
gtggacggcg tggaagtgca taacgccaag accaagccca gagaggagca gttcaacagc       900
acctacagag tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa       960
tacaagtgca aggtctccaa caagggcctg gccagcagca tcgagaagac catcagcaag      1020
gccaagggcc agccacggga gccccaggtc tgcaccctgc cacctagcca agaggagatg      1080
accaagaacc aggtgtccct gagctgtgcc gtgaaaggct tctatcccag cgatatcgcc      1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      1200
gacagcgacg gcagcttctt cctggtttcc aagctgaccg tggacaagtc cagatggcag      1260
gagggcaacg tcttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      1320
aagtccctga gcctgagcct gggcaag                                          1347

<210>  122
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  122
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210>  123
<211>  125
<212>  PRT
<213>  Mus musculus

<400>  123
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

