﻿                         序列表

<110>  中国人民解放军军事科学院军事医学研究院

<120>  一种结合破伤风毒素重链C端结构域的人源抗体及应用

<160>  10

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1
Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      
Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe Ser Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Tyr Arg Asn Gly Ser Thr Asn Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe Val 
65                  70                  75                  80  
Gln Met Asn Arg Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Phe Val Val Val Val Ser Thr Gly Pro Glu Val Ser Tyr Tyr 
            100                 105                 110         
Ser Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Gly Ser 
        115                 120                 125             
Ser 
    

<210>  2
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  2
cagctggtgc agtctggagg aggcttgatc cagccggggg ggtccctgag actctcctgt        60
gcagcctcag ggtctggatt cagtgtcagt agtaattaca tgacctgggt ccgccaggct       120
ccagggaagg ggctggagtg ggtcgcagtt atttatagga atggcagtac aaactacgca       180
gactccgtga ggggccgatt caccatctcc agagataatt ccaagaacac ggtgtttgtt       240
caaatgaaca gactgagagt cgaggacacg gccgtttatt actgtgcgag agatttcgtc       300
gtggtggtga gtactggtcc ggaggtgtcg tactactcct acgggatgga cgtctggggc       360
caggggacca tggtcaccgg ctcctca                                           387

<210>  3
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  3
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Pro 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Phe Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  4
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  4
gcgtcgacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcccgcacc aggactggct gaatggcaaa       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatt ccgggatgag       720
ctgaccaaga accaggtcag cctgacctgc ctggtcaagg gcttctatcc cagcgacatc       780
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg       840
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg       900
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg       960
cagaagagcc tctccctgtc tccgggtaaa                                        990

<210>  5
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  5
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              
Tyr Gly Thr Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln His His Gly Phe Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         

<210>  6
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  6
gacatcgtga tgacccagtc tccttcctcc ctgtctgcat ctgttggaga cagagtcacc        60
atcacttgca gggcaagtca gggcattagc gattatttaa gttggtatca gcagaaacca       120
ggaaaagctc ctaagcgcct catctatggt acatccagtt tggacagtgg ggtcccatcg       180
aggttcagcg gcagtggatc tgggacagaa ttcaccctca ccatcagcag cctgcagcct       240
gaagatgttg caacttatta ctgtctacag catcatggtt tccctcgcac ttttggccag       300
gggaccaaag tggatatcaa ac                                                322

<210>  7
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  7
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  8
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  8
cgtactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct        60
ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag       120
tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac       180
agcaaggaca gcacctacag cctcagcagt accctgacgc tgagcaaagc agactacgag       240
aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagttcgcc cgtcacaaag       300
agcttcaaca ggggagagtg t                                                 321

<210>  9
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  9
Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  
Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     

<210>  10
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  10
cgtcagccca aggctgcccc ctcggtcact ctgttcccac cctcgagtga ggagcttcaa        60
gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg       120
gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa       180
caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag       240
tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg       300
gcccctacag aatgttca                                                     318

