                         SEQUENCE LISTING

<110>  Rockefeller University
       Seattle Children's Research Institute
       New York University
 
<120>  SINGLE-DOMAIN ANTIBODIES THAT BIND SARS-COV-2

<130>  S281-0032PCT / SCRI.352WO

<150>  US63/197,270
<151>  2021-06-04

<150>  US63/068,720
<151>  2020-08-21

<160>  595   

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-1

<400>  1

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Pro Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Val Asn Trp Asn Gly Ile Ser Thr Tyr Leu Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ala Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Ser Lys Gly Trp Ser Glu Trp Gly Met Asp Tyr 
            100                 105                 110         


Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120         


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-2

<400>  2

Met Ala Gln Thr Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ile Arg 
            20                  25                  30          


Pro Asn Val Met Ala Trp Tyr Arg Gln Gly Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Ser Ile His Ser Ser Gly Thr Lys Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Ser Thr Trp Ala Thr Gln Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser 
        115                 


<210>  3
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-3

<400>  3

Met Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser 
            20                  25                  30          


Asn Thr Gly Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Trp Val Ala Ser Ile Ser Pro Ser Gly Ser Thr Ser Tyr Leu Asp Ser 
    50                  55                  60                  


Val Arg Gly Arg Phe Ile Phe Ser Arg Asp Asn Ala Lys Asn Ile Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Thr Leu Pro Arg Ser Gly Ser Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  4
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-4

<400>  4

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Val Asp Trp Ser Gly Gly Asp Thr Leu Tyr Thr Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Ala Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Arg Gly Tyr Ser Leu Tyr Tyr Tyr Gln Ala Arg 
            100                 105                 110         


Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  5
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-5

<400>  5

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Gly 
            20                  25                  30          


Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Cys Ile Gly Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Lys Gly Pro Pro Gln Gly Val Leu Arg Cys Ser Ile 
            100                 105                 110         


Ser Gly Arg Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  6
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-6

<400>  6

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Val Val Ser Gly Arg Thr Ser Ser 
            20                  25                  30          


Phe Phe Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Val Ile Arg Gly Ser Gly Gly Val Thr Phe Tyr Ser Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Ser Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gly Ser Asp Phe Gly Asp His Gly Pro Leu Ser Gly Arg 
            100                 105                 110         


Thr Asp Phe Ser Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  7
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-7

<400>  7

Met Ala Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Val 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Thr 
            20                  25                  30          


Ser Ser Met Tyr Gly Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        35                  40                  45              


Arg Glu Phe Val Ala Val Ile Gly Trp Asn Thr Tyr Tyr Ala Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Arg Lys Ala Ala Gly Leu Ala Ser Gly Tyr Pro Ser Pro 
            100                 105                 110         


Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  8
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-9

<400>  8

Met Ala Gln Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Val Ser Gly Ser 
            20                  25                  30          


Ala Phe Arg Phe Asn Arg Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Glu Arg Glu Leu Val Ala Ser Ile Ser Ser Gly Gly Ser Thr Asn Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Ser Thr Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Asn Ile Arg Ala Asp Phe Phe Ser Ser Thr Arg Thr 
            100                 105                 110         


Gly Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  9
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-10

<400>  9

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Ala Gly Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Thr Ser Asn Trp Asn Gly Gly Asp Thr Asp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Leu Gln Lys Tyr Gly Gly Asp Tyr Tyr Ala Arg 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120             


<210>  10
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-11

<400>  10

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Phe 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser 
            20                  25                  30          


Pro Tyr Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Cys Ile Ser Val Thr Gly Gly Thr Thr Asp Tyr Thr Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ala Arg Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Thr Ala Ser Phe Cys Arg Gly Asp Tyr Ser Ala 
            100                 105                 110         


Ser Val Ala Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  11
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-12

<400>  11

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Val Ala Ile Ser Trp Lys Ser Gly Leu Ile Thr Ala Ala Asn 
    50                  55                  60                  


Phe Leu Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Ala Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Val Asp Pro Asn Asn Arg Arg Gly Thr Leu Thr Ser Tyr 
            100                 105                 110         


Tyr Asp His Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125 


<210>  12
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-14

<400>  12

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser 
            20                  25                  30          


Arg Leu Ser Met Gly Trp Tyr Arg Gln Val Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Arg Ile Leu Pro Leu Gly Gly Pro Tyr Tyr Arg Asp Phe 
    50                  55                  60                  


Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Met Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Arg Ala Pro Phe Gly Thr Ala Trp Asp Gly Pro Asp Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  13
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-17

<400>  13

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Leu Ala Ser Thr 
            20                  25                  30          


Tyr Ser Ala Lys Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asn Arg Ser Gly Gly Ile Thr Ser Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Lys Val Thr Leu Ser Asp Asp Thr Tyr Asn Gln Pro 
            100                 105                 110         


Gly Asn Tyr Pro Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-19

<400>  14

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Ser Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Gly Ile Ser Pro Asp Gly Ser Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Val Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Arg Ile Phe Leu Pro Glu Ile Pro Gly Arg Gly Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser 
        115                 


<210>  15
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-20

<400>  15

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Pro Leu Asp 
            20                  25                  30          


Phe Tyr Ala Ile Gly Trp Phe Arg Gln Ala Ser Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Ser Cys Ile Ser Arg Arg Asp Asp Tyr Thr Ser Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gly Val Arg Thr Ser Ser Gly Thr Val Cys Gln Ala Tyr 
            100                 105                 110         


Pro Arg Trp Tyr Asp Thr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  16
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-21

<400>  16

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Ala Val Arg 
            20                  25                  30          


Ala Ser Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Thr Ile Asn Ile Gly Gly Ser Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Glu Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Lys Ala Gln Tyr Tyr Thr Gly Tyr Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-23

<400>  17

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Ser Arg 
            20                  25                  30          


Pro Tyr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Phe Trp Ser Gly Ser His Thr Leu Tyr Glu Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Gln Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Asn Gln Ala Thr Gly Asn Tyr Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser 
        115                 120 


<210>  18
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-24

<400>  18

Met Ala Gln Val Gln Pro Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Thr Thr Thr 
            20                  25                  30          


Asn Tyr His Met Gly Trp Tyr Arg Gln Thr Pro Gly Glu Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Ala Ile Asn Ala Gly Gly Ile Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asn Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ile Gly Gly Gly Trp Asp Tyr Arg Asn Ser Tyr Tyr Ile Pro 
            100                 105                 110         


Arg Val Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  19
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-25

<400>  19

Met Ala Gln Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Val Ser Gly Ser 
            20                  25                  30          


Gly Phe Arg Phe Asn Arg Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Glu Arg Glu Leu Val Ala Ser Ile Ser Ser Gly Gly Ser Thr Asn Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Ser Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Asn Ile Arg Ala Asp Phe Phe Thr Ser Thr Arg Thr 
            100                 105                 110         


Gly Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  20
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-27

<400>  20

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Gly Thr Phe Gly 
            20                  25                  30          


Ser Ser Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Met Pro Ser Gly Ser His Thr Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr 
65                  70                  75                  80  


Ile Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Gly Ala Arg Asp Pro Ser Ser Tyr Thr Tyr Asp Arg Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser 
        115                 120 


<210>  21
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-28

<400>  21

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Arg Thr Leu Ser 
            20                  25                  30          


Ser Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Arg Trp Asn Gly Gly Ser Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Gln Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Pro Arg Thr Met Tyr Tyr Ala Ser Tyr Tyr Tyr 
            100                 105                 110         


Thr Arg Thr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser 
    


<210>  22
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-29

<400>  22

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Gln Ala Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Phe Ser 
            20                  25                  30          


Ser Ala Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Leu Ile Ala Gly Ile Ser Trp Ser Ala Leu Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Gln Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


His Cys Ala Ala Arg Thr Arg Ser His Phe Tyr Ser Glu Val Tyr Arg 
            100                 105                 110         


Arg Ala Ser Asp Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser 
    


<210>  23
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-30

<400>  23

Met Ala Gln Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Ser Thr Phe Ser 
            20                  25                  30          


Thr Ser His Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Ser Ile Ser Thr Glu Gly Thr Thr Glu Tyr Ala Asp Phe 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Gln Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Ala Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His 
                85                  90                  95      


Cys Asn Arg Gly Gly Trp Arg Tyr Tyr Gly Asp Gly Ser His Tyr Ile 
            100                 105                 110         


Pro Asp Phe Arg Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  24
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-31

<400>  24

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser 
            20                  25                  30          


Ile Ile Tyr Arg Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Gly Glu 
        35                  40                  45              


Phe Val Ala Ser Ile Asp Thr Ala Gly Ser Thr Thr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Lys Tyr Val Thr Trp Ala Pro Arg Val Glu Tyr Arg Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser 
        115             


<210>  25
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-32

<400>  25

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Ala Phe Ser 
            20                  25                  30          


Leu Tyr His Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Thr Ala Ile Asn Trp Asn Gly Gly Ile Ala Asp Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Lys Leu Gly Ala Tyr Tyr Thr Thr Tyr Arg Lys Ala 
            100                 105                 110         


Asn Glu Tyr Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  26
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-35

<400>  26

Met Ala Gln Val His Leu Ile Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Leu Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Phe Ile Glu Trp Ser Gly Ala Glu Thr Tyr Tyr Thr Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Ile Leu Gln Met Asn Ser Val Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Lys Gly Tyr Ser Leu Tyr Tyr Tyr Arg Glu Ser 
            100                 105                 110         


Asp Tyr Glu Tyr Trp Gly Gln Gly Thr Arg Val Thr Val Ser 
        115                 120                 125     


<210>  27
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-36

<400>  27

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Glu Arg Ile Leu Ser 
            20                  25                  30          


Ser Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Arg Trp Asn Gly Gly Ser Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Pro Arg Thr Met Tyr Leu Ala Ser Tyr Tyr Tyr 
            100                 105                 110         


His Arg Thr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser 
    


<210>  28
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-37

<400>  28

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Pro Leu Asp 
            20                  25                  30          


Phe Phe Ala Ile Gly Trp Phe Arg Gln Ala Ser Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Ser Cys Ile Ser Arg Arg Asp Asp Tyr Thr Ser Tyr Val Asp 
    50                  55                  60                  


Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gly Val Arg Thr Ser Ser Asp Thr Val Cys Gln Asn Tyr 
            100                 105                 110         


Pro Arg Trp Tyr Leu Thr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  29
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-38

<400>  29

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Tyr Ala Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu 
        35                  40                  45              


Phe Val Gly Trp Met Ala Trp Ser Gly Pro Ala Lys Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Lys Glu Ile Thr Thr Met Thr Thr Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120             


<210>  30
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-39

<400>  30

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Gly 
            20                  25                  30          


Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Cys Val Ser Ala Ile Asn Trp Ser Gly Asp His Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Gly Pro Asn Glu Trp Gly Leu Pro Arg Glu Asp 
            100                 105                 110         


Leu Phe Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  31
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-41

<400>  31

Met Ala Gln Val Pro Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Ser Thr Phe Ser 
            20                  25                  30          


Thr Tyr His Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Ala Ile Asn Ser Glu Gly Ser Thr Tyr Tyr Pro Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Ala Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His 
                85                  90                  95      


Cys Asn Arg Gly Gly Trp Arg Tyr Tyr Gly Asp Gly Ser Arg Tyr Ile 
            100                 105                 110         


Pro Asp Phe Arg Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  32
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-46

<400>  32

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Val Ser Cys Val Ile Ser Gly His Gln Phe Ser 
            20                  25                  30          


Asp Tyr Val Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Gly Ala Ile Trp Trp Ser Asp Asp Ile Thr Tyr Tyr Glu Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


His Cys Ala Val Arg Phe Arg Pro Val Ser Thr Tyr Gln Val Arg Ser 
            100                 105                 110         


Thr Asp Asp Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  33
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-48

<400>  33

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Asp 
            20                  25                  30          


Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Leu Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gly Ser Leu Thr Arg Tyr Gly Ser Ser Trp His Val 
            100                 105                 110         


Pro Phe Gly Ser Arg Ser Tyr Glu Asn Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser 
    130     


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-49

<400>  34

Met Ala Gln Ile Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Ile 
            20                  25                  30          


Phe Ser Ile Gly Ala Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
        35                  40                  45              


Arg Glu Leu Val Ala Gln Ile Ser Ser Gly Gly Ile Thr Asn Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Asp Glu Thr Thr Pro Trp Gly Ala Thr Arg Gly 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120         


<210>  35
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-50

<400>  35

Met Ala Gln Thr Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ile Arg 
            20                  25                  30          


Pro Asn Val Met Ala Trp Tyr Arg Gln Gly Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Ser Met His Ser Ser Gly Thr Lys Asn Tyr Ala Glu Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Ser Thr Trp Ala Gly Gln Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser 
        115                 


<210>  36
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-51

<400>  36

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
            20                  25                  30          


Asn Tyr Tyr Met Val Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Thr Thr Trp Leu Ser Asn Thr Tyr Tyr Thr Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Glu Gln Ser Gly Arg Asp Trp Arg Arg Thr Ser Pro 
            100                 105                 110         


Ser Pro Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  37
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-52

<400>  37

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser 
            20                  25                  30          


Leu Asn Ala Lys Ala Trp Tyr Arg Gln Ala Pro Gly Ser Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Arg Ile Thr Gly Ser Gly Thr Ile Thr Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr 
65                  70                  75                  80  


Val Thr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Ile Cys Ala Ala Ala Pro Gly Gly Leu Trp Thr Gly Pro Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120     


<210>  38
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-53

<400>  38

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Thr 
            20                  25                  30          


Asn Tyr Trp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Ser Val Ala Thr Ile Thr Tyr Gly Ala Gly Met Lys Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Glu Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Ser Pro Gln Arg Pro Tyr Ser Gly Phe Gly Ser Asp Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120             


<210>  39
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-54

<400>  39

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser 
            20                  25                  30          


Lys Tyr Ala Val Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Thr Ile Asn His Ser Gly Asp Thr Lys Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ile Gly Ile Trp Ile Ala Ser Ala His Ser Pro Asp Gly Arg 
            100                 105                 110         


Ala Asp His Trp Gly Arg Gly Thr Gln Val Thr Val Ser 
        115                 120                 125 


<210>  40
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-55

<400>  40

Met Ala Gln Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Gly 
            20                  25                  30          


Met Arg Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Val Ile Ser Thr Ser Gly Gly Asp Thr Ser Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Val Pro Arg Ile Gly Ala Trp Ser Arg Ser Pro Arg Asp 
            100                 105                 110         


Tyr Asp Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125 


<210>  41
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-56

<400>  41

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser 
            20                  25                  30          


Ile Asp Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Pro Val Ala His Ile Arg Asn Thr Gly Thr Thr Ala Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Glu Leu Lys Asp Phe Leu Gly Gly Val Ile Pro Leu Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120         


<210>  42
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-58

<400>  42

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser 
            20                  25                  30          


Ala Tyr Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Ala Ile Ser Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Thr Val Gly Trp Asp Tyr Arg Tyr Asp Tyr Pro Ile Thr Gly 
            100                 105                 110         


Arg Asn Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  43
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-60

<400>  43

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser 
            20                  25                  30          


Thr Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Leu Val Ala Glu Ile Thr Thr Asp Gly Thr Thr Arg Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Thr Val Thr Arg Phe Leu Gly Gly Leu Leu Arg Pro Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120         


<210>  44
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-61

<400>  44

Met Ala Gln Val Gln Leu Ile Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Gly Trp Leu Arg Gln Ala Pro Gly Glu Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Arg Gly Met Asp Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Lys Met Val Ala Pro Ile Phe Val Val Val Thr Thr 
            100                 105                 110         


Arg Asp Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  45
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-62

<400>  45

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Pro Ser Gly Arg Thr Ser Asn 
            20                  25                  30          


Thr Tyr Pro Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Thr Arg Ser Val Pro Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gly Ser Ser Asn Val Tyr Leu Leu Thr Arg Asp Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  46
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-63

<400>  46

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Phe 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser 
            20                  25                  30          


Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Ser Val Ala Leu Ile Met Asn Asn Gly Asn Thr Tyr Tyr Glu Asn Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Val Ala Tyr Arg Asp Tyr Asp Arg Lys Arg Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120         


<210>  47
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-64

<400>  47

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser 
            20                  25                  30          


Val Asn Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Leu Val Ala Thr Ile Thr Ser His Gly Ile Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys His Arg Glu Asp Thr Gly Leu Trp Asn Ser Lys Asp Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120     


<210>  48
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-65

<400>  48

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn 
            20                  25                  30          


Val Asn Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Leu Val Ala Thr Ile Thr Thr Arg Gly Ile Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Gly Asn Ala Lys Asp Thr Val 
65                  70                  75                  80  


His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Arg Glu Asp Thr Gly Leu Trp Asn Ser Lys Asp Val Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120     


<210>  49
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-66

<400>  49

Met Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Thr Arg Thr Phe Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ala Phe Val Ala Ala 
        35                  40                  45              


Ile Ser Trp Asn Gly Val Ser Ile Thr Tyr Ala Asp Ser Val Ala Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Leu Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Ala Asp Val Val Ala Gly Thr Arg Trp Thr Asp Tyr Asn Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser 
        115                 120 


<210>  50
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-3

<400>  50

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp 
            20                  25                  30          


Thr Thr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Cys Ile Ser Thr Ser Gly Glu Arg Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Ser Cys Ala Ala Lys Tyr Ala Ser Phe Gln Tyr Leu Pro Val Gly Leu 
            100                 105                 110         


Pro Trp Ser Met Tyr Asp Val Arg Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser 
    


<210>  51
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-4

<400>  51

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Leu Gly 
            20                  25                  30          


Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Phe Ile Ser Arg His Gly Ser Thr Thr Tyr Tyr Thr Lys 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Lys Thr Thr Ala Trp Asp Thr Ile Arg Val Ser 
            100                 105                 110         


Ala Ile Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  52
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-5

<400>  52

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Leu Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Phe Ile Glu Trp Asn Gly Gly Asp Thr Tyr Tyr Thr Asp 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Arg Ala Tyr Ser Leu Tyr Tyr Tyr Arg Val Ser 
            100                 105                 110         


Glu Tyr Gln Tyr Trp Gly Gln Gly Thr Arg Val Thr Val Ser 
        115                 120                 125     


<210>  53
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-6

<400>  53

Met Gly Gln Val Gln Val Ala Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr 
            20                  25                  30          


Thr Asn Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Trp Ser Thr Gly Thr Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Arg Ser Ala Phe Asn Ala Tyr Ala Trp Thr Thr Glu 
            100                 105                 110         


Arg Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  54
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-9

<400>  54

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Val Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Leu Ile Thr Trp Ser Gly Ala Asp Arg Tyr Tyr Gly Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Arg Gly Ser Ser Tyr His Tyr Ala Glu Ser Lys 
            100                 105                 110         


Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  55
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-10

<400>  55

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Arg 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Val Ile Thr Ala Thr Asp Asp Ile Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Tyr Gly Asp Ser Tyr Tyr Tyr Thr Arg Arg Thr 
            100                 105                 110         


Glu Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  56
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-11

<400>  56

Met Ala Gln Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Thr Asp Ser 
            20                  25                  30          


Asn Tyr Val Met Gly Trp Tyr Arg Gln Thr Ala Gly Lys Gln Arg Glu 
        35                  40                  45              


Trp Val Ala Ser Ile Asn Ser Gly Gly Glu Thr Arg Ser Val Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Phe Tyr Glu Arg Leu Ala Trp Asp Pro Ser Thr Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser 
        115                 


<210>  57
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-12

<400>  57

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Leu Ser 
            20                  25                  30          


Ile Asn Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Leu Val Ala Phe Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Glu Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys His Ala Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Asp Ile Arg Glu Ser Gly Phe Val Tyr Gly Met Asn Ala 
            100                 105                 110         


Trp Gly Lys Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125     


<210>  58
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-14

<400>  58

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Val Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser 
            20                  25                  30          


Ile Asn Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Trp Ser Gly Ser Lys Thr Val Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


His Cys Ala Val Ala Ser Arg Gly Pro Val Tyr Gly Ala Asn Tyr Val 
            100                 105                 110         


Pro Gly Pro His Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser 
    130 


<210>  59
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-15

<400>  59

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ser Ile Asn Trp Asn Gly Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Thr Gly Pro Asn Glu Tyr Gly Leu Pro Arg Glu Asp 
            100                 105                 110         


Leu Phe Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  60
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-16

<400>  60

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Gly Phe Asp 
            20                  25                  30          


Arg Tyr Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Gly Gly Ile Asn Trp Asn Gly Ala Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Gln His Tyr Met Gly Ser Pro Pro Pro Lys Glu 
            100                 105                 110         


Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  61
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-18

<400>  61

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ile Thr Phe Ser 
            20                  25                  30          


Gly Tyr Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Gly Trp Ile Ser His Gly Gly Ile Lys Asp Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Arg Lys Asp Ala Gln Ser Ser Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  62
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-19

<400>  62

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser 
            20                  25                  30          


Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Thr Ile Ser Gly Thr Gly Gly Asn Thr Ala Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Pro Pro Ser Trp Tyr Thr Arg Arg Tyr Ile Asn Phe 
            100                 105                 110         


Ala Pro Ser Glu Val Arg His Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser 
    


<210>  63
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-20

<400>  63

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Arg Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Gly Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Asp 
        35                  40                  45              


Phe Val Ala Val Ile Arg Trp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Asn Val Lys Asn Thr Val 
65                  70                  75                  80  


Phe Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Thr Asp Arg Thr His Tyr Asp Ile Val Glu Tyr Thr Arg 
            100                 105                 110         


Asp His Phe Tyr Ser Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  64
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-21

<400>  64

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser 
            20                  25                  30          


Asp Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Thr Ile Asp Ser Thr Gly Ser Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Val Asn Ala Glu Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Arg Phe Gly Gly Gly Arg Met Glu Tyr Arg Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  65
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-22

<400>  65

Met Ala Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ala Tyr Thr Leu Ala Trp Phe Arg Leu Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala His Ile Asp Trp Ser Gly Thr Glu Thr Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Asn Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Leu Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Arg Ala Tyr Ser Leu Met Tyr Tyr Asp Thr Arg 
            100                 105                 110         


Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  66
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-23

<400>  66

Met Ala Gln Val His Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Phe Glu 
            20                  25                  30          


Asn Asn Ala Ile Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Leu Val Ser Gly Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu 
                85                  90                  95      


Cys Gln Ala Val Ala Trp Asp Ser Arg Arg Arg Ser Val Val Ala Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120         


<210>  67
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-24

<400>  67

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly His Thr Phe Gly 
            20                  25                  30          


Ser Leu Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Thr Asp Trp Ser Gly Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Thr Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Asp Arg Ala Ala Ser Leu Tyr Pro Leu Arg Asp Gln Ala Asp 
            100                 105                 110         


Tyr Met Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125 


<210>  68
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-25

<400>  68

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp 
            20                  25                  30          


Tyr Tyr Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Tyr Ile Ser Ser Ser Gly Ser Asn Thr Tyr Tyr Glu Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Arg Val Trp Gln Glu Thr Ile Val Val Arg Gly 
            100                 105                 110         


Pro Glu His Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  69
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-26

<400>  69

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Arg Thr Phe Gly 
            20                  25                  30          


Gly Tyr Gly Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Thr Ser Thr Ser Phe Gly Thr Ser Tyr Ala Asp 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Thr Leu Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Val Leu Ser Pro Pro Pro Arg Thr Asn Ser Ala 
            100                 105                 110         


Tyr Ala Tyr Trp Gly Gln Gly Ile Gln Val Thr Val Ser 
        115                 120                 125 


<210>  70
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-27

<400>  70

Met Ala Gln Val His Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Gly 
            20                  25                  30          


Ile Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Thr Gly Asp Ala Ser Asp Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Gln Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Phe Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Thr Gly Ala Ile Thr Arg Ala Thr Met Trp Lys Pro 
            100                 105                 110         


Asn Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  71
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-28

<400>  71

Met Ala Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser 
            20                  25                  30          


Thr Asp Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ile Ser Trp Arg Ser Asp Asp Thr Tyr Tyr Ala Asp Asn 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Ala Asp Gln Gly Arg Ser Tyr Tyr Tyr Thr Arg Glu Ser Glu 
            100                 105                 110         


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125 


<210>  72
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-29

<400>  72

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Asp 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ala Ser Ile 
            20                  25                  30          


Val Phe Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Leu Gly Ser Gly Gln Ser Thr Tyr Tyr Gly Asn 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Gly Gly Arg Leu Asp Leu Val Asn Thr Thr Gly Gly 
            100                 105                 110         


Tyr Glu Pro Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  73
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-30

<400>  73

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Leu Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Phe Ile Glu Trp Ser Gly Ala Glu Thr Tyr Tyr Thr Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Ala Ala Tyr Ser Leu Tyr Tyr Tyr Arg Val Ser 
            100                 105                 110         


Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Arg Val Thr Val Ser 
        115                 120                 125     


<210>  74
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-32

<400>  74

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp 
            20                  25                  30          


Tyr Tyr Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Tyr Ile Ser Ser Ser Gly Ser Asn Ser Tyr Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Arg Val Trp Gln Pro Thr Ile Val Val Ser Gly 
            100                 105                 110         


Pro Glu His Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  75
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-34

<400>  75

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Thr Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp 
        35                  40                  45              


Phe Val Ala Ala Ile Asn Trp Asn Gly Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Pro Ser Asp Gly Arg Val Val Gly Tyr Asn Tyr 
            100                 105                 110         


Val Pro Val Ser Thr His Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser 
    130         


<210>  76
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-35

<400>  76

Met Thr Gln Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Thr Asp Ser 
            20                  25                  30          


Asn Tyr Val Met Gly Trp Tyr Arg Gln Ala Ser Gly Lys Gln Arg Glu 
        35                  40                  45              


Trp Val Ala Ser Ile Asn Ser Gly Gly Asp Thr Lys Ser Val Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ile Asp Asn Ala Lys Asn Thr Met 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Phe Tyr Glu Lys Leu Ala Trp Asp Pro Ser Thr Thr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser 
        115                 


<210>  77
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-36

<400>  77

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Thr Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asn Trp Ser Gly Gly Ser Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Pro Ser Asp Gly Arg Val Phe Gly Val Asn Tyr 
            100                 105                 110         


Val Pro Val Ser Thr His Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser 
    130         


<210>  78
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-37

<400>  78

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asp Ser Phe Ser 
            20                  25                  30          


Phe Arg Trp Tyr Gly Met Asn Trp Tyr Arg Gln Gly Pro Gly Lys Pro 
        35                  40                  45              


Arg Glu Trp Val Ala Gly Ile Ser Ser Ala Gly Ser Thr Asn Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Tyr Ser Ala Thr Gln Glu Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser 
        115             


<210>  79
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-38

<400>  79

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Asp 
            20                  25                  30          


Asn Tyr Pro Val Thr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Phe Val Ala Ser Ile Arg Ser Gly His Ile Thr Asn Tyr Ala Asn Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Met Ser Lys Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Tyr Thr Val Asp Ala Gln Ser Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  80
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-39

<400>  80

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Thr Phe Ser 
            20                  25                  30          


Ser Asp Val Met Ala Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Trp Val Ala Ser Phe Ser Ser Ser Gly Ser Gly Asn Tyr Ala Ala Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr 
                85                  90                  95      


Cys His Ala Ala His Val Asn Gly Gly Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  81
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-40

<400>  81

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser 
            20                  25                  30          


Asn Tyr Gly Met Val Trp Trp Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Phe Val Ala Ser Ile Ser Ser Gly Arg Asp Thr Asn Tyr Ala Asp Phe 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Tyr Thr Val Thr Asp Arg Ser Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  82
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-41

<400>  82

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser 
            20                  25                  30          


Arg Ser Ala Val Gly Trp His Arg Gln Ala Pro Gly Lys Pro Arg Glu 
        35                  40                  45              


Trp Val Ala Ala Ile Ser Asn Ser Gly Thr Thr Ser Tyr Thr Asp Pro 
    50                  55                  60                  


Met Lys Gly Arg Val Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ile Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Tyr Ile Ala Asp Gly Leu Leu Gly Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser 
        115             


<210>  83
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-43

<400>  83

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser 
            20                  25                  30          


Ser Asp Val Ile Thr Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Trp Val Ala Ser Ile Gln Ser Ser Gly Ser Arg Asn Tyr Ala Ala Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr 
                85                  90                  95      


Cys His Ala Gly His Val Thr Gly Gly Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  84
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-44

<400>  84

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Ser Thr Val Ser 
            20                  25                  30          


Asn Ser Pro Met Asp Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Phe Val Ala Thr Val Gln Ser Gly Gly Asn Ala Ser Tyr Ser Tyr Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys His Ala Ala Asp Asp Arg Ser Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  85
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-45

<400>  85

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Leu Ala Ser Gly Ile Thr Trp Met 
            20                  25                  30          


Pro Tyr Gly Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Val 
        35                  40                  45              


Phe Val Ala Thr Ile Ser Ser Asn Gly Arg Thr Asn Tyr Ala Ala Ser 
    50                  55                  60                  


Val Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys His Gly Ala Thr Ala Leu Ser Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  86
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-46

<400>  86

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Ser Thr Leu Gly 
            20                  25                  30          


Ser Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Phe Ile Ser Arg Asp Gly Ser Thr Thr Phe Tyr Thr Ser 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Lys Ile Thr Ala Trp Asp Thr Ile Ile Val Ser 
            100                 105                 110         


Ala Ile Glu Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  87
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-47

<400>  87

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ser Phe Ser 
            20                  25                  30          


Thr Tyr Asp Met Asn Trp Phe Arg Gln Thr Pro Gly Lys Gln Gln Glu 
        35                  40                  45              


Trp Val Ala Gly Ile Gly Thr Leu Asn Ser Pro Arg Tyr Ala Asn Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Thr Ala Ser Asp Arg Asp Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  88
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-48

<400>  88

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Asp 
            20                  25                  30          


Asn Tyr Asn Ile Gly Phe Ile Glu Trp Phe Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Glu Arg Thr Phe Val Ala Thr Ile Ser Arg Ser Gly Asp Ile Thr Asn 
    50                  55                  60                  


Tyr Ala Gly Ser Val Ala Gly Arg Phe Thr Ile Ser Arg Asp Asn Asn 
65                  70                  75                  80  


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys His Met Ser Met Thr Thr Gly Gly Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120     


<210>  89
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-49

<400>  89

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala Ser Thr Phe Ser 
            20                  25                  30          


Ile Gly Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Phe Val Ala Thr Ile Thr Ser Ser Gly Thr Thr Ser Tyr Ala Gly Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Tyr Ala Asn Asn Leu His Gly Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  90
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S1-RBD-51

<400>  90

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Leu Ser 
            20                  25                  30          


Thr Tyr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Lys 
        35                  40                  45              


Phe Val Ala Ala Ile Phe Trp Ser Gly Gly His Thr Val Tyr Glu Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Gln Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Asn Pro Ala Thr Gly Asn Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Ile Thr Val Ser 
        115                 120 


<210>  91
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-1

<400>  91

Met Ala Gln Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Leu Val Leu Gly 
            20                  25                  30          


Gly Tyr Asp Met Arg Trp Tyr Arg Gln Val Pro Gly Asn Gly Arg Glu 
        35                  40                  45              


Leu Val Ala Ser Ile Ser Asn Gly Gly Ser Thr Asp Tyr Ala Asp Phe 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Val Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Met Arg Ser Thr Tyr Tyr Gly Ile Asp Tyr Trp Gly Arg Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser 
        115             


<210>  92
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-2

<400>  92

Met Ala Gln Val Arg Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Gln Phe Ser 
            20                  25                  30          


Arg Ile Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Thr Leu Ser Thr Arg Gly Thr Thr Asn Tyr Pro Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Thr Gly Pro Gly Tyr Lys Thr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  93
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-3

<400>  93

Met Ala Gln Ile Leu Val Thr Gln Ser Gly Gly Gly Leu Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Leu Val Leu Gly 
            20                  25                  30          


Gly Tyr Asp Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Leu Val Ala Ser Ile Thr Asn Gly Gly Asp Thr Arg Tyr Val Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Ala Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Met His Ser Thr Tyr Tyr Gly Arg Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser 
        115             


<210>  94
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-4

<400>  94

Met Thr Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Val Ser Ser Glu Pro Thr Phe Ser 
            20                  25                  30          


Ser Arg Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp 
        35                  40                  45              


Asn Val Ala Thr Ile Pro Trp Trp Arg Gly Ala Leu Pro Tyr Tyr Lys 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn 
65                  70                  75                  80  


Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Ser Lys Thr Trp Ser Pro Ser Thr Gly Val Ala 
            100                 105                 110         


Thr Glu Tyr Glu Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  95
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-5

<400>  95

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Leu Thr Phe Lys 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Thr Ile Asn Ser Ile Gly Gly Pro Ala Asn Tyr Ala Asn 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Glu Arg Thr Pro Ser Thr Leu Leu Ala Gly Ser Ser 
            100                 105                 110         


Asn Pro Ser Arg Val Asp Val Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser 
    


<210>  96
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-6

<400>  96

Met Thr Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Gly Ile Phe Gly 
            20                  25                  30          


Gly Ser Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Glu 
        35                  40                  45              


Met Val Ala Thr Ile Ser Asn Ser Gly Ser Ala Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ala Lys Arg Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Lys His Ser Ile Tyr Tyr Gly Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser 
        115             


<210>  97
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-7

<400>  97

Met Thr Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Pro Thr Phe Ser 
            20                  25                  30          


Ser Arg Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Ser Val Ala Ala Ile Pro Trp Trp Lys Gly Ala Leu Pro Tyr Tyr Lys 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn 
65                  70                  75                  80  


Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Ser Lys Thr Trp Ser Pro Tyr Thr Asp Ala Ala 
            100                 105                 110         


Thr Glu Leu Glu Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  98
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-9

<400>  98

Met Leu Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser 
            20                  25                  30          


Thr Tyr Gly Val Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Ser Ile Asn Ser Trp Gly Trp Ile Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr 
                85                  90                  95      


Cys Asn Ser Gln Asn Ser Arg Gly Asp Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  99
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-10

<400>  99

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Val Ser 
            20                  25                  30          


Ser Ser Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Val Ile Ala Ser Ser Asn Ser His Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Ser His Leu Thr Ile Ala Ala Trp Glu Arg Leu 
            100                 105                 110         


Lys Thr Tyr Asp Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  100
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-11

<400>  100

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Gly Ala Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ser Ile Leu Trp Arg Tyr Glu Tyr Thr Asn Tyr Ala Asn 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Lys Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Cys Ala Ile Glu Arg Ser Gly Ile Tyr Tyr His Glu Asp 
            100                 105                 110         


Ser Asn Lys Tyr Gln Tyr Trp Gly Gln Gly Thr Gln Val Ser Val Ser 
        115                 120                 125             


<210>  101
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-13

<400>  101

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Met Thr 
            20                  25                  30          


Tyr Tyr Thr Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Ser Ser Ser Arg Ile Thr Gly Asn Thr Tyr Tyr Thr Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Gly Arg Asn Ile Asn Tyr Tyr Thr Asn Ser Ala Gln Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  102
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-14

<400>  102

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Pro Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Pro Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Gly Ile Gly Trp Tyr Ser Gly Thr Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Ile Ile Lys Asn Thr 
65                  70                  75                  80  


Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Lys Asp Arg Tyr Gly Asn Met Asp Pro Asn Gly 
            100                 105                 110         


Val Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  103
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-15

<400>  103

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Trp Tyr Asn Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Ser Leu Thr Asp Ile Ser Arg Ser Gly Gly Asn 
    50                  55                  60                  


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
65                  70                  75                  80  


Asn Ala Lys Asn Thr Val Tyr Met Gln Met Asp Ser Leu Lys Pro Glu 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Asp Arg Arg Met Pro Ala 
            100                 105                 110         


Ala Ile Met Thr Ser Val Arg Asp Tyr Val Tyr Arg Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser 
    130             


<210>  104
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-18

<400>  104

Met Thr Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Ser Thr Phe Ser 
            20                  25                  30          


Ser Arg Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp 
        35                  40                  45              


Phe Val Ala Ala Ile Pro Trp Trp Ile Gly Ala Leu Pro Asn Tyr Lys 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn 
65                  70                  75                  80  


Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Ser Lys Thr Trp Ser Pro Arg Thr Asp Val Thr 
            100                 105                 110         


Glu Leu Glu Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  105
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-22

<400>  105

Met Ala Gln Val His Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Trp Tyr Asn Leu Ala Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Gly Arg Ile Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Glu Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Lys Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


His Cys Ala Ala Asp Asp Arg Arg Met Pro Ala Ala Ile Met Thr Ser 
            100                 105                 110         


Ala Arg Asp Tyr Val Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  106
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-26

<400>  106

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Phe Ser 
            20                  25                  30          


Arg Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Ser Asn Asp Lys Ala Thr Tyr Tyr Lys Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu His Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Pro Val Leu Lys Met Thr Pro Asp Ile Met Ala 
            100                 105                 110         


Ser Arg Tyr Val Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  107
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-33

<400>  107

Met Ala Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Ala Asn 
            20                  25                  30          


Met Arg Val Met Lys Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Gly Thr Met Phe Asn Pro Gly Pro Thr Met Tyr Arg Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Asn Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Val Asp Pro Arg Asn Tyr Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  108
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-35

<400>  108

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Arg Ile Ser Ser 
            20                  25                  30          


Val Glu Val Leu Gly Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Leu Val Ala Thr Leu Thr Arg Ala Gly Thr Thr Asn Tyr Ile Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Arg Asp Leu Ile Gly Gln Asn Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


His Val Thr Val Ser 
        115         


<210>  109
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-36

<400>  109

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Ala Thr 
            20                  25                  30          


Asn Tyr Val Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Gln Glu 
        35                  40                  45              


Leu Val Ala Ser Ile Ser Asn Asp Gly Ser Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu 
                85                  90                  95      


Cys His Leu Lys His Trp Trp Phe Gly Phe Ala Lys Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120     


<210>  110
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-39

<400>  110

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Ala 
1               5                   10                  15      


Gly Glu Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Ile Ser 
            20                  25                  30          


Arg Tyr Ala Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Phe Val Ala Glu Ile Ser Ser Gly Gly Thr Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ala Lys Asn Thr Met 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Lys Val Ser Tyr Thr Thr Tyr Ser Gly Gln Gly Thr Arg Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  111
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-40

<400>  111

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Trp Tyr Asn Leu Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Ser Arg Ile Ala Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Glu Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Met Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


His Cys Ala Ala Asp Asp Arg Trp Met Pro Ala Ala Thr Met Thr Ser 
            100                 105                 110         


Val Arg Asp Tyr Val Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  112
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-42

<400>  112

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Trp Tyr Asn Leu Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Phe Glu 
        35                  40                  45              


Phe Val Gly Gly Ile Ser Arg Thr Ala Gly Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Glu Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Ile Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


His Cys Ala Ala Asp Asp Arg Arg Met Ala Ala Ala Thr Met Thr Ser 
            100                 105                 110         


Val Arg Asp Tyr Val Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  113
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-47

<400>  113

Met Ala Gln Val Arg Val Glu Glu Ser Gly Gly Asp Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Thr Thr Ser Ala Ile Leu Asn Thr 
            20                  25                  30          


Trp Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Gln Ile Thr Ser Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Arg Gln Asn Ile Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Leu Arg Ala Asp Arg Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  114
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-58

<400>  114

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Ile Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Thr Ile Thr Trp Ser Gly Lys Leu Thr Met Tyr Gln Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Pro Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Glu Lys Gly Trp Lys Gln Val Ser Pro Asp Asp 
            100                 105                 110         


Val Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125 


<210>  115
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-59

<400>  115

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Gln Ala Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser 
            20                  25                  30          


Asn Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ala Lys Trp Ser Asp Ile Asn Glu Ser Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Gly Gly Tyr Tyr Ser Asp Asn Ile Arg Gln Thr 
            100                 105                 110         


Asp Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  116
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Domain of S2-62

<400>  116

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Ala Met Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ser Ile Asp Trp Arg Tyr Gln Tyr Arg Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Cys Gln Ile Gln Arg Asp Gly Ile Tyr Tyr Tyr Glu Asp 
            100                 105                 110         


Ser Ser Lys Tyr Gln Tyr Trp Gly Gln Gly Thr Gln Val Ser Val Ser 
        115                 120                 125             


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-1

<400>  117

Met Pro Phe Ser Ser Tyr Ala Met Gly 
1               5                   


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-1

<400>  118

Ala Val Asn Trp Asn Gly Ile Ser Thr Tyr 
1               5                   10  


<210>  119
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-1

<400>  119

Asp Ser Lys Gly Trp Ser Glu Trp Gly Met Asp Tyr 
1               5                   10          


<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-2 and S1-50

<400>  120

Ser Ile Ile Arg Pro Asn Val Met Ala 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-2

<400>  121

Ser Ile His Ser Ser Gly Thr Lys Asn 
1               5                   


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-2

<400>  122

Arg Ser Thr Trp Ala Thr Gln Pro Asp Tyr 
1               5                   10  


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-3

<400>  123

Ser Thr Phe Ser Asn Thr Gly Leu Gly 
1               5                   


<210>  124
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-3

<400>  124

Ser Ile Ser Pro Ser Gly Ser Thr Ser 
1               5                   


<210>  125
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-3

<400>  125

Leu Pro Arg Ser Gly Ser 
1               5       


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-4

<400>  126

Arg Thr Phe Ser Ser Tyr Phe Met Ala 
1               5                   


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-4

<400>  127

Ala Val Asp Trp Ser Gly Gly Asp Thr Leu 
1               5                   10  


<210>  128
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-4

<400>  128

Asp Arg Gly Tyr Ser Leu Tyr Tyr Tyr Gln Ala Arg Glu Tyr Glu Tyr 
1               5                   10                  15      


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-5 and S1-RBD-4

<400>  129

Phe Thr Leu Gly Tyr Tyr Ala Ile Gly 
1               5                   


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-5

<400>  130

Cys Ile Gly Ser Ser Asp Gly Ser Thr Tyr 
1               5                   10  


<210>  131
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-5

<400>  131

Lys Gly Pro Pro Gln Gly Val Leu Arg Cys Ser Ile Ser Gly Arg Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-6

<400>  132

Arg Thr Ser Ser Phe Phe Ser Met Ala 
1               5                   


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-6

<400>  133

Val Ile Arg Gly Ser Gly Gly Val Thr Phe 
1               5                   10  


<210>  134
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-6

<400>  134

Ser Asp Phe Gly Asp His Gly Pro Leu Ser Gly Arg Thr Asp Phe Ser 
1               5                   10                  15      


Ser 
    


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-7

<400>  135

Arg Thr Tyr Thr Ser Ser Met Tyr Gly Met Ala 
1               5                   10      


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-7

<400>  136

Val Ile Gly Trp Asn Thr Tyr 
1               5           


<210>  137
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-7

<400>  137

Arg Lys Ala Ala Gly Leu Ala Ser Gly Tyr Pro Ser Pro Ser Tyr Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-9

<400>  138

Val Ser Gly Ser Ala Phe Arg Phe Asn Arg Leu Gly 
1               5                   10          


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-9 and S1-25

<400>  139

Ser Ile Ser Ser Gly Gly Ser Thr Asn 
1               5                   


<210>  140
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-9

<400>  140

Arg Ala Asp Phe Phe Ser Ser Thr Arg Thr Gly Asp 
1               5                   10          


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-10

<400>  141

Arg Thr Phe Ser Ser Ala Gly Met Ala 
1               5                   


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-10

<400>  142

Thr Ser Asn Trp Asn Gly Gly Asp Thr Asp 
1               5                   10  


<210>  143
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-10

<400>  143

His Leu Gln Lys Tyr Gly Gly Asp Tyr Tyr Ala Arg Ile 
1               5                   10              


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-11

<400>  144

Phe Thr Leu Ser Pro Tyr Asp Ile Gly 
1               5                   


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-11

<400>  145

Cys Ile Ser Val Thr Gly Gly Thr Thr Asp 
1               5                   10  


<210>  146
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-11

<400>  146

His Thr Ala Ser Phe Cys Arg Gly Asp Tyr Ser Ala Ser Val Ala Arg 
1               5                   10                  15      


Tyr 
    


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-12

<400>  147

Arg Thr Phe Ser Asn Tyr Ala Met Gly 
1               5                   


<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-12

<400>  148

Ala Ile Ser Trp Lys Ser Gly Leu Ile Thr 
1               5                   10  


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-12

<400>  149

Asp Pro Asn Asn Arg Arg Gly Thr Leu Thr Ser Tyr Tyr Asp His 
1               5                   10                  15  


<210>  150
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-14

<400>  150

Ser Thr Phe Ser Arg Leu Ser Met Gly 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-14

<400>  151

Arg Ile Leu Pro Leu Gly Gly Pro Tyr 
1               5                   


<210>  152
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-14

<400>  152

Ala Pro Phe Gly Thr Ala Trp Asp Gly Pro Asp Asn Tyr Asp Tyr 
1               5                   10                  15  


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-17

<400>  153

Leu Ala Ser Thr Tyr Ser Ala Lys Gly 
1               5                   


<210>  154
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-17

<400>  154

Ala Ile Asn Arg Ser Gly Gly Ile Thr Ser 
1               5                   10  


<210>  155
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-17

<400>  155

Lys Val Thr Leu Ser Asp Asp Thr Tyr Asn Gln Pro Gly Asn Tyr Pro 
1               5                   10                  15      


Ser 
    


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-19

<400>  156

Ser Thr Phe Ser Ser Tyr Ala Met Gly 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-19

<400>  157

Gly Ile Ser Pro Asp Gly Ser Thr Asn 
1               5                   


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-19

<400>  158

Phe Leu Pro Glu Ile Pro Gly Arg Gly Ser 
1               5                   10  


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-20

<400>  159

Phe Pro Leu Asp Phe Tyr Ala Ile Gly 
1               5                   


<210>  160
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-20 and S1-37

<400>  160

Cys Ile Ser Arg Arg Asp Asp Tyr Thr Ser 
1               5                   10  


<210>  161
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-20

<400>  161

Val Arg Thr Ser Ser Gly Thr Val Cys Gln Ala Tyr Pro Arg Trp Tyr 
1               5                   10                  15      


Asp Thr 
        


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-21

<400>  162

Ile Ala Val Arg Ala Ser Thr Met Gly 
1               5                   


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-21

<400>  163

Thr Ile Asn Ile Gly Gly Ser Thr Asn 
1               5                   


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-21

<400>  164

Gln Tyr Tyr Thr Gly Tyr Asp Tyr 
1               5               


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-23

<400>  165

Arg Thr Ser Arg Pro Tyr Arg Met Gly 
1               5                   


<210>  166
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-23

<400>  166

Ala Ile Phe Trp Ser Gly Ser His Thr Leu 
1               5                   10  


<210>  167
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-23

<400>  167

Arg Asn Gln Ala Thr Gly Asn Tyr Asp Val 
1               5                   10  


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-24

<400>  168

Ser Thr Thr Thr Asn Tyr His Met Gly 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-24

<400>  169

Ala Ile Asn Ala Gly Gly Ile Thr Asn 
1               5                   


<210>  170
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-24

<400>  170

Gly Gly Gly Trp Asp Tyr Arg Asn Ser Tyr Tyr Ile Pro Arg Val Asp 
1               5                   10                  15      


Ser 
    


<210>  171
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-25

<400>  171

Val Ser Gly Ser Gly Phe Arg Phe Asn Arg Leu Gly 
1               5                   10          


<210>  172

<400>  172
000

<210>  173
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-25

<400>  173

Arg Ala Asp Phe Phe Thr Ser Thr Arg Thr Gly Asp 
1               5                   10          


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-27

<400>  174

Gly Thr Phe Gly Ser Ser Arg Met Gly 
1               5                   


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-27

<400>  175

Ala Ile Met Pro Ser Gly Ser His Thr Asn 
1               5                   10  


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-27

<400>  176

Arg Asp Pro Ser Ser Tyr Thr Tyr Asp Arg 
1               5                   10  


<210>  177
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-28

<400>  177

Arg Thr Leu Ser Ser Tyr Val Met Gly 
1               5                   


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-28 and S1-36

<400>  178

Ala Ile Arg Trp Asn Gly Gly Ser Thr Phe 
1               5                   10  


<210>  179
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-28

<400>  179

Ser Pro Arg Thr Met Tyr Tyr Ala Ser Tyr Tyr Tyr Thr Arg Thr Ser 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-29

<400>  180

Asp Thr Phe Ser Ser Ala Pro Met Gly 
1               5                   


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-29

<400>  181

Gly Ile Ser Trp Ser Ala Leu Asn Thr Tyr 
1               5                   10  


<210>  182
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-29

<400>  182

Arg Thr Arg Ser His Phe Tyr Ser Glu Val Tyr Arg Arg Ala Ser Asp 
1               5                   10                  15      


Tyr Asp Phe 
            


<210>  183
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-30

<400>  183

Ser Thr Phe Ser Thr Ser His Met Gly 
1               5                   


<210>  184
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-30

<400>  184

Ser Ile Ser Thr Glu Gly Thr Thr Glu 
1               5                   


<210>  185
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-30

<400>  185

Gly Gly Trp Arg Tyr Tyr Gly Asp Gly Ser His Tyr Ile Pro Asp Phe 
1               5                   10                  15      


Arg Phe 
        


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-31

<400>  186

Ser Ile Ser Ser Ile Ile Tyr Arg Gly 
1               5                   


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-31

<400>  187

Ser Ile Asp Thr Ala Gly Ser Thr Thr 
1               5                   


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-31

<400>  188

Val Thr Trp Ala Pro Arg Val Glu Tyr 
1               5                   


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-32

<400>  189

Val Ala Phe Ser Leu Tyr His Met Ala 
1               5                   


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-32

<400>  190

Ala Ile Asn Trp Asn Gly Gly Ile Ala Asp 
1               5                   10  


<210>  191
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-32

<400>  191

Lys Leu Gly Ala Tyr Tyr Thr Thr Tyr Arg Lys Ala Asn Glu Tyr Gln 
1               5                   10                  15      


Tyr 
    


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-35

<400>  192

Arg Thr Phe Ser Ser Leu Val Met Ala 
1               5                   


<210>  193
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-36 and S1-RBD-30

<400>  193

Phe Ile Glu Trp Ser Gly Ala Glu Thr Tyr 
1               5                   10  


<210>  194
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-35

<400>  194

Asp Lys Gly Tyr Ser Leu Tyr Tyr Tyr Arg Glu Ser Asp Tyr Glu Tyr 
1               5                   10                  15      


<210>  195
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-36

<400>  195

Arg Ile Leu Ser Ser Tyr Val Met Gly 
1               5                   


<210>  196

<400>  196
000

<210>  197
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-36

<400>  197

Ser Pro Arg Thr Met Tyr Leu Ala Ser Tyr Tyr Tyr His Arg Thr Ser 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  198
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-37

<400>  198

Phe Pro Leu Asp Phe Phe Ala Ile Gly 
1               5                   


<210>  199

<400>  199
000

<210>  200
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-37

<400>  200

Val Arg Thr Ser Ser Asp Thr Val Cys Gln Asn Tyr Pro Arg Trp Tyr 
1               5                   10                  15      


Leu Thr 
        


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-38

<400>  201

Arg Thr Phe Ser Tyr Ala Ile Met Gly 
1               5                   


<210>  202
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-38

<400>  202

Trp Met Ala Trp Ser Gly Pro Ala Lys Tyr 
1               5                   10  


<210>  203
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-38

<400>  203

Ser Lys Glu Ile Thr Thr Met Thr Thr Arg Tyr Asp Tyr 
1               5                   10              


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-39

<400>  204

Arg Thr Phe Gly Ser Tyr Ala Met Gly 
1               5                   


<210>  205
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-39

<400>  205

Ala Ile Asn Trp Ser Gly Asp His Thr Tyr 
1               5                   10  


<210>  206
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-39

<400>  206

Arg Gly Pro Asn Glu Trp Gly Leu Pro Arg Glu Asp Leu Phe Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-41

<400>  207

Ser Thr Phe Ser Thr Tyr His Met Gly 
1               5                   


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-41

<400>  208

Ala Ile Asn Ser Glu Gly Ser Thr Tyr 
1               5                   


<210>  209
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-41

<400>  209

Gly Gly Trp Arg Tyr Tyr Gly Asp Gly Ser Arg Tyr Ile Pro Asp Phe 
1               5                   10                  15      


Arg Ser 
        


<210>  210
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-46

<400>  210

His Gln Phe Ser Asp Tyr Val Ile Gly 
1               5                   


<210>  211
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-46

<400>  211

Ala Ile Trp Trp Ser Asp Asp Ile Thr Tyr 
1               5                   10  


<210>  212
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-46

<400>  212

Arg Phe Arg Pro Val Ser Thr Tyr Gln Val Arg Ser Thr Asp Asp Tyr 
1               5                   10                  15      


Gly Tyr 
        


<210>  213
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-48

<400>  213

Ile Thr Leu Asp Tyr Tyr Ala Ile Gly 
1               5                   


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-48

<400>  214

Leu Ile Ser Ser Ser Asp Gly Ser Thr Tyr 
1               5                   10  


<210>  215
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-48

<400>  215

Gly Ser Leu Thr Arg Tyr Gly Ser Ser Trp His Val Pro Phe Gly Ser 
1               5                   10                  15      


Arg Ser Tyr Glu Asn 
            20      


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-49

<400>  216

Ser Ile Phe Ser Ile Gly Ala Met Ser 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-49

<400>  217

Gln Ile Ser Ser Gly Gly Ile Thr Asn 
1               5                   


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-49

<400>  218

Asp Glu Thr Thr Pro Trp Gly Ala Thr Arg Gly 
1               5                   10      


<210>  219

<400>  219
000

<210>  220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-50

<400>  220

Ser Met His Ser Ser Gly Thr Lys Asn 
1               5                   


<210>  221
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-50

<400>  221

Arg Ser Thr Trp Ala Gly Gln Pro Asp Tyr 
1               5                   10  


<210>  222
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-51

<400>  222

Phe Ser Phe Ser Asn Tyr Tyr Met Val 
1               5                   


<210>  223
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-51

<400>  223

Ala Ile Thr Thr Trp Leu Ser Asn Thr Tyr 
1               5                   10  


<210>  224
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-51

<400>  224

Glu Gln Ser Gly Arg Asp Trp Arg Arg Thr Ser Pro Ser Pro Tyr Ala 
1               5                   10                  15      


Tyr 
    


<210>  225
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-52

<400>  225

Ser Ile Phe Ser Leu Asn Ala Lys Ala 
1               5                   


<210>  226
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-52

<400>  226

Arg Ile Thr Gly Ser Gly Thr Ile Thr Asn 
1               5                   10  


<210>  227
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-52

<400>  227

Ala Pro Gly Gly Leu Trp Thr Gly Pro Ala Tyr 
1               5                   10      


<210>  228
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-53

<400>  228

Tyr Thr Ile Thr Asn Tyr Trp Met Ala 
1               5                   


<210>  229
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-53

<400>  229

Thr Ile Thr Tyr Gly Ala Gly Met Lys Tyr 
1               5                   10  


<210>  230
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-53

<400>  230

Pro Gln Arg Pro Tyr Ser Gly Phe Gly Ser Asp Asp Tyr 
1               5                   10              


<210>  231
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-54

<400>  231

Ile Ile Phe Ser Lys Tyr Ala Val Ala 
1               5                   


<210>  232
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-54

<400>  232

Thr Ile Asn His Ser Gly Asp Thr Lys 
1               5                   


<210>  233
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-54

<400>  233

Gly Ile Trp Ile Ala Ser Ala His Ser Pro Asp Gly Arg Ala Asp His 
1               5                   10                  15      


<210>  234
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-55

<400>  234

Arg Thr Phe Gly Met Arg Ala Met Gly 
1               5                   


<210>  235
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-55

<400>  235

Val Ile Ser Thr Ser Gly Gly Asp Thr Ser 
1               5                   10  


<210>  236
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-55

<400>  236

Pro Arg Ile Gly Ala Trp Ser Arg Ser Pro Arg Asp Tyr Asp Ile 
1               5                   10                  15  


<210>  237
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-56

<400>  237

Ser Ile Phe Ser Ile Asp Ala Met Gly 
1               5                   


<210>  238
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-56

<400>  238

His Ile Arg Asn Thr Gly Thr Thr Ala 
1               5                   


<210>  239
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-56

<400>  239

Leu Lys Asp Phe Leu Gly Gly Val Ile Pro Leu Asn Ser 
1               5                   10              


<210>  240
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-58

<400>  240

Ser Thr Phe Ser Ala Tyr Ser Met Gly 
1               5                   


<210>  241
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-58

<400>  241

Ala Ile Ser Ser Gly Gly Ser Thr Asn 
1               5                   


<210>  242
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-58

<400>  242

Val Gly Trp Asp Tyr Arg Tyr Asp Tyr Pro Ile Thr Gly Arg Asn Asp 
1               5                   10                  15      


Tyr 
    


<210>  243
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-60

<400>  243

Ser Thr Phe Ser Thr Asn Ala Met Gly 
1               5                   


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-60

<400>  244

Glu Ile Thr Thr Asp Gly Thr Thr Arg 
1               5                   


<210>  245
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-60

<400>  245

Val Thr Arg Phe Leu Gly Gly Leu Leu Arg Pro Asp Tyr 
1               5                   10              


<210>  246
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-61 and S1-RBD-15

<400>  246

Arg Thr Phe Ser Ser Tyr Ala Met Gly 
1               5                   


<210>  247
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-61

<400>  247

Ala Ile Ser Arg Arg Gly Met Asp Thr Tyr 
1               5                   10  


<210>  248
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-61

<400>  248

Lys Met Val Ala Pro Ile Phe Val Val Val Thr Thr Arg Asp Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  249
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-62

<400>  249

Arg Thr Ser Asn Thr Tyr Pro Met Ala 
1               5                   


<210>  250
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-62

<400>  250

Ala Ile Thr Arg Ser Val Pro Asn Thr Tyr 
1               5                   10  


<210>  251
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-62

<400>  251

Ser Ser Asn Val Tyr Leu Leu Thr Arg Asp Glu Tyr Asp Tyr 
1               5                   10                  


<210>  252
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-63

<400>  252

Ile Ile Phe Ser Ile Asn Ala Met Gly 
1               5                   


<210>  253
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-63

<400>  253

Leu Ile Met Asn Asn Gly Asn Thr Tyr 
1               5                   


<210>  254
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-63

<400>  254

Val Ala Tyr Arg Asp Tyr Asp Arg Lys Arg Tyr Asp Tyr 
1               5                   10              


<210>  255
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-64

<400>  255

Ser Ile Phe Ser Val Asn Ser Met Gly 
1               5                   


<210>  256
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-64

<400>  256

Thr Ile Thr Ser His Gly Ile Thr Asn 
1               5                   


<210>  257
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-64

<400>  257

Glu Asp Thr Gly Leu Trp Asn Ser Lys Asp Thr Tyr 
1               5                   10          


<210>  258
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-65

<400>  258

Ser Ile Phe Asn Val Asn Ser Met Gly 
1               5                   


<210>  259
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-65

<400>  259

Thr Ile Thr Thr Arg Gly Ile Thr Asn 
1               5                   


<210>  260
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-65

<400>  260

Glu Asp Thr Gly Leu Trp Asn Ser Lys Asp Val Tyr 
1               5                   10          


<210>  261
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-66

<400>  261

Arg Thr Phe Met Gly 
1               5   


<210>  262
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-66

<400>  262

Ala Ile Ser Trp Asn Gly Val Ser Ile Thr 
1               5                   10  


<210>  263
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-66

<400>  263

Ala Asp Val Val Ala Gly Thr Arg Trp Thr Asp Tyr Asn Tyr 
1               5                   10                  


<210>  264
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-3

<400>  264

Phe Thr Leu Asp Thr Thr Ala Ile Gly 
1               5                   


<210>  265
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-3

<400>  265

Cys Ile Ser Thr Ser Gly Glu Arg Thr Tyr 
1               5                   10  


<210>  266
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-3

<400>  266

Lys Tyr Ala Ser Phe Gln Tyr Leu Pro Val Gly Leu Pro Trp Ser Met 
1               5                   10                  15      


Tyr Asp Val 
            


<210>  267

<400>  267
000

<210>  268
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-4

<400>  268

Phe Ile Ser Arg His Gly Ser Thr Thr Tyr 
1               5                   10  


<210>  269
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-4

<400>  269

Ser Lys Thr Thr Ala Trp Asp Thr Ile Arg Val Ser Ala Ile Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  270
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-5 and S1-RBD-30

<400>  270

Arg Thr Phe Ser Ser Leu Val Met Gly 
1               5                   


<210>  271
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-5

<400>  271

Phe Ile Glu Trp Asn Gly Gly Asp Thr Tyr 
1               5                   10  


<210>  272
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-5

<400>  272

Asp Arg Ala Tyr Ser Leu Tyr Tyr Tyr Arg Val Ser Glu Tyr Gln Tyr 
1               5                   10                  15      


<210>  273
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-6

<400>  273

Arg Thr Phe Thr Thr Asn Ala Met Gly 
1               5                   


<210>  274
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-6

<400>  274

Ala Ile Ser Trp Ser Thr Gly Thr Thr Tyr 
1               5                   10  


<210>  275
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-6

<400>  275

Arg Ser Ala Phe Asn Ala Tyr Ala Trp Thr Thr Glu Arg Ala Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  276
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-9

<400>  276

Arg Thr Phe Ser Asn Tyr Val Val Ala 
1               5                   


<210>  277
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-9

<400>  277

Leu Ile Thr Trp Ser Gly Ala Asp Arg Tyr 
1               5                   10  


<210>  278
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-9

<400>  278

Asp Arg Gly Ser Ser Tyr His Tyr Ala Glu Ser Lys Asn Tyr Asp Tyr 
1               5                   10                  15      


<210>  279
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-10

<400>  279

Arg Thr Phe Arg Asn Tyr Ala Met Gly 
1               5                   


<210>  280
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-10

<400>  280

Val Ile Thr Ala Thr Asp Asp Ile Thr Tyr 
1               5                   10  


<210>  281
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-10

<400>  281

Asp Tyr Gly Asp Ser Tyr Tyr Tyr Thr Arg Arg Thr Glu Tyr Gly Tyr 
1               5                   10                  15      


<210>  282
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-11 and S1-RBD-35

<400>  282

Ser Thr Asp Ser Asn Tyr Val Met Gly 
1               5                   


<210>  283
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-11

<400>  283

Ser Ile Asn Ser Gly Gly Glu Thr Arg 
1               5                   


<210>  284
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-11

<400>  284

Glu Arg Leu Ala Trp Asp Pro Ser Thr Ser 
1               5                   10  


<210>  285
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-12

<400>  285

Ser Ile Leu Ser Ile Asn Asp Met Gly 
1               5                   


<210>  286
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-12

<400>  286

Phe Ile Thr Ser Gly Gly Ser Thr Asn 
1               5                   


<210>  287
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-12

<400>  287

Asp Ile Arg Glu Ser Gly Phe Val Tyr Gly Met Asn Ala Trp Gly Lys 
1               5                   10                  15      


Tyr 
    


<210>  288
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-14

<400>  288

Arg Ser Phe Ser Ile Asn Pro Met Gly 
1               5                   


<210>  289
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-14

<400>  289

Ala Ile Ser Trp Ser Gly Ser Lys Thr Val 
1               5                   10  


<210>  290
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-14

<400>  290

Ala Ser Arg Gly Pro Val Tyr Gly Ala Asn Tyr Val Pro Gly Pro His 
1               5                   10                  15      


Glu Tyr Glu Tyr 
            20  


<210>  291

<400>  291
000

<210>  292
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-15

<400>  292

Ser Ile Asn Trp Asn Gly Gly Asn Thr Tyr 
1               5                   10  


<210>  293
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-15

<400>  293

Thr Gly Pro Asn Glu Tyr Gly Leu Pro Arg Glu Asp Leu Phe Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  294
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-16

<400>  294

Arg Gly Phe Asp Arg Tyr Pro Met Gly 
1               5                   


<210>  295
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-16

<400>  295

Gly Ile Asn Trp Asn Gly Ala Asn Thr Tyr 
1               5                   10  


<210>  296
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-16

<400>  296

Asp Gln His Tyr Met Gly Ser Pro Pro Pro Lys Glu Tyr Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  297
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-18

<400>  297

Ile Thr Phe Ser Gly Tyr Val Met Ala 
1               5                   


<210>  298
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-18

<400>  298

Trp Ile Ser His Gly Gly Ile Lys Asp 
1               5                   


<210>  299
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-18

<400>  299

Lys Asp Ala Gln Ser Ser 
1               5       


<210>  300
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-19

<400>  300

Phe Ser Phe Ser Ser Tyr Gly Met Gly 
1               5                   


<210>  301
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-19

<400>  301

Thr Ile Ser Gly Thr Gly Gly Asn Thr Ala 
1               5                   10  


<210>  302
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-19

<400>  302

Pro Pro Ser Trp Tyr Thr Arg Arg Tyr Ile Asn Phe Ala Pro Ser Glu 
1               5                   10                  15      


Val Arg His 
            


<210>  303
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-20

<400>  303

Arg Thr Phe Ser Ser Gly Ala Met Ala 
1               5                   


<210>  304
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-20

<400>  304

Val Ile Arg Trp Ser Gly Ser Thr Tyr 
1               5                   


<210>  305
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-20

<400>  305

Thr Asp Arg Thr His Tyr Asp Ile Val Glu Tyr Thr Arg Asp His Phe 
1               5                   10                  15      


Tyr Ser Asn 
            


<210>  306
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-21

<400>  306

Arg Ala Phe Ser Asp Tyr Gly Met Gly 
1               5                   


<210>  307
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-21

<400>  307

Thr Ile Asp Ser Thr Gly Ser Asn Thr Tyr 
1               5                   10  


<210>  308
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-21

<400>  308

Asp Arg Phe Gly Gly Gly Arg Met Glu Tyr Arg Tyr Glu Tyr 
1               5                   10                  


<210>  309
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-22

<400>  309

Arg Thr Phe Ser Ala Tyr Thr Leu Ala 
1               5                   


<210>  310
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-22

<400>  310

His Ile Asp Trp Ser Gly Thr Glu Thr Asn 
1               5                   10  


<210>  311
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-22

<400>  311

Asp Arg Ala Tyr Ser Leu Met Tyr Tyr Asp Thr Arg Glu Tyr Glu Tyr 
1               5                   10                  15      


<210>  312
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-23

<400>  312

Ser Gly Phe Glu Asn Asn Ala Ile Thr 
1               5                   


<210>  313
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-23

<400>  313

Gly Ile Thr Ser Gly Gly Ser Thr Asn 
1               5                   


<210>  314
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-23

<400>  314

Val Ala Trp Asp Ser Arg Arg Arg Ser Val Val Ala Phe 
1               5                   10              


<210>  315
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-24

<400>  315

His Thr Phe Gly Ser Leu Thr Met Ala 
1               5                   


<210>  316
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-24

<400>  316

Gly Thr Asp Trp Ser Gly Ile Asn 
1               5               


<210>  317
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-24

<400>  317

Asp Arg Ala Ala Ser Leu Tyr Pro Leu Arg Asp Gln Ala Asp Tyr Met 
1               5                   10                  15      


Tyr 
    


<210>  318
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-25 and S1-RBD-32

<400>  318

Phe Thr Leu Asp Tyr Tyr Thr Ile Gly 
1               5                   


<210>  319
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-25

<400>  319

Tyr Ile Ser Ser Ser Gly Ser Asn Thr Tyr 
1               5                   10  


<210>  320
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-25

<400>  320

Arg Arg Val Trp Gln Glu Thr Ile Val Val Arg Gly Pro Glu His Tyr 
1               5                   10                  15      


Glu Tyr 
        


<210>  321
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-26

<400>  321

Arg Thr Phe Gly Gly Tyr Gly Val Gly 
1               5                   


<210>  322
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-26

<400>  322

Gly Ile Thr Ser Thr Ser Phe Gly Thr Ser 
1               5                   10  


<210>  323
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-26

<400>  323

Ser Val Leu Ser Pro Pro Pro Arg Thr Asn Ser Ala Tyr Ala Tyr 
1               5                   10                  15  


<210>  324
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-27

<400>  324

Arg Thr Phe Gly Ile Tyr Asn Met Gly 
1               5                   


<210>  325
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-27

<400>  325

Ala Ile Thr Gly Asp Ala Ser Asp Thr Tyr 
1               5                   10  


<210>  326
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-27

<400>  326

Thr Gly Ala Ile Thr Arg Ala Thr Met Trp Lys Pro Asn Phe 
1               5                   10                  


<210>  327
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-28

<400>  327

Arg Thr Ile Ser Thr Asp Ala Met Gly 
1               5                   


<210>  328
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-28

<400>  328

Ile Ser Trp Arg Ser Asp Asp Thr Tyr 
1               5                   


<210>  329
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-28

<400>  329

Asp Gln Gly Arg Ser Tyr Tyr Tyr Thr Arg Glu Ser Glu Tyr Asn Tyr 
1               5                   10                  15      


<210>  330
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-29

<400>  330

Leu Ala Ser Ile Val Phe Asn Met Gly 
1               5                   


<210>  331
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-29

<400>  331

Gly Ile Leu Gly Ser Gly Gln Ser Thr Tyr 
1               5                   10  


<210>  332
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-29

<400>  332

Gly Gly Arg Leu Asp Leu Val Asn Thr Thr Gly Gly Tyr Glu Pro Thr 
1               5                   10                  15      


Tyr 
    


<210>  333

<400>  333
000

<210>  334

<400>  334
000

<210>  335
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-30

<400>  335

Asp Ala Ala Tyr Ser Leu Tyr Tyr Tyr Arg Val Ser Glu Tyr Glu Tyr 
1               5                   10                  15      


<210>  336

<400>  336
000

<210>  337
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-32

<400>  337

Tyr Ile Ser Ser Ser Gly Ser Asn Ser Tyr 
1               5                   10  


<210>  338
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-32

<400>  338

Arg Arg Val Trp Gln Pro Thr Ile Val Val Ser Gly Pro Glu His Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  339
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-34 and S1-RBD-36

<400>  339

Arg Thr Phe Ser Thr Thr Phe Met Gly 
1               5                   


<210>  340
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-34

<400>  340

Ala Ile Asn Trp Asn Gly Gly Ser Thr Arg 
1               5                   10  


<210>  341
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-34

<400>  341

Asp Pro Ser Asp Gly Arg Val Val Gly Tyr Asn Tyr Val Pro Val Ser 
1               5                   10                  15      


Thr His Glu Tyr Asp Tyr 
            20          


<210>  342

<400>  342
000

<210>  343
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-35

<400>  343

Ser Ile Asn Ser Gly Gly Asp Thr Lys 
1               5                   


<210>  344
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-35

<400>  344

Glu Lys Leu Ala Trp Asp Pro Ser Thr Thr 
1               5                   10  


<210>  345

<400>  345
000

<210>  346
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-36

<400>  346

Ala Ile Asn Trp Ser Gly Gly Ser Thr Arg 
1               5                   10  


<210>  347
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-36

<400>  347

Asp Pro Ser Asp Gly Arg Val Phe Gly Val Asn Tyr Val Pro Val Ser 
1               5                   10                  15      


Thr His Glu Tyr Asp Tyr 
            20          


<210>  348
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-37

<400>  348

Asp Ser Phe Ser Phe Arg Trp Tyr Gly Met Asn 
1               5                   10      


<210>  349
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-37

<400>  349

Gly Ile Ser Ser Ala Gly Ser Thr Asn 
1               5                   


<210>  350
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-37

<400>  350

Ala Thr Gln Glu Arg Asp Tyr 
1               5           


<210>  351
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-38

<400>  351

Ser Thr Phe Asp Asn Tyr Pro Val Thr 
1               5                   


<210>  352
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-38

<400>  352

Ser Ile Arg Ser Gly His Ile Thr Asn 
1               5                   


<210>  353
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-38

<400>  353

Val Asp Ala Gln Ser Asp Tyr 
1               5           


<210>  354
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-39

<400>  354

Ser Thr Phe Ser Ser Asp Val Met Ala 
1               5                   


<210>  355
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-39

<400>  355

Ser Phe Ser Ser Ser Gly Ser Gly Asn 
1               5                   


<210>  356
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-39

<400>  356

Ala His Val Asn Gly Gly Asp Ser 
1               5               


<210>  357
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-40

<400>  357

Ile Thr Phe Ser Asn Tyr Gly Met Val 
1               5                   


<210>  358
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-40

<400>  358

Ser Ile Ser Ser Gly Arg Asp Thr Asn 
1               5                   


<210>  359
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-40

<400>  359

Val Thr Asp Arg Ser Asp Tyr 
1               5           


<210>  360
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-41

<400>  360

Ile Thr Phe Ser Arg Ser Ala Val Gly 
1               5                   


<210>  361
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-41

<400>  361

Ala Ile Ser Asn Ser Gly Thr Thr Ser 
1               5                   


<210>  362
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-41

<400>  362

Ala Asp Gly Leu Leu Gly Gly Asp Tyr 
1               5                   


<210>  363
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-43

<400>  363

Ser Thr Phe Ser Ser Asp Val Ile Thr 
1               5                   


<210>  364
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-43

<400>  364

Ser Ile Gln Ser Ser Gly Ser Arg Asn 
1               5                   


<210>  365
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-43

<400>  365

Gly His Val Thr Gly Gly Asp Ser 
1               5               


<210>  366
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-44

<400>  366

Ser Thr Val Ser Asn Ser Pro Met Asp 
1               5                   


<210>  367
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-44

<400>  367

Thr Val Gln Ser Gly Gly Asn Ala Ser 
1               5                   


<210>  368
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-44

<400>  368

Ala Asp Asp Arg Ser Asp Tyr 
1               5           


<210>  369
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-45

<400>  369

Ile Thr Trp Met Pro Tyr Gly Met Glu 
1               5                   


<210>  370
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-45

<400>  370

Thr Ile Ser Ser Asn Gly Arg Thr Asn 
1               5                   


<210>  371
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-45

<400>  371

Ala Thr Ala Leu Ser Asp Tyr 
1               5           


<210>  372
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-46

<400>  372

Ser Thr Leu Gly Ser Tyr Ala Ile Gly 
1               5                   


<210>  373
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-46

<400>  373

Phe Ile Ser Arg Asp Gly Ser Thr Thr Phe 
1               5                   10  


<210>  374
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-46

<400>  374

Ser Lys Ile Thr Ala Trp Asp Thr Ile Ile Val Ser Ala Ile Glu Tyr 
1               5                   10                  15      


Thr Tyr 
        


<210>  375
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-47

<400>  375

Ile Ser Phe Ser Thr Tyr Asp Met Asn 
1               5                   


<210>  376
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-47

<400>  376

Gly Ile Gly Thr Leu Asn Ser Pro Arg 
1               5                   


<210>  377
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-47

<400>  377

Ala Ser Asp Arg Asp Tyr 
1               5       


<210>  378
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-48

<400>  378

Arg Thr Phe Asp Asn Tyr Asn Ile Gly Phe Ile Glu 
1               5                   10          


<210>  379
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-48

<400>  379

Thr Ile Ser Arg Ser Gly Asp Ile Thr Asn 
1               5                   10  


<210>  380
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-48

<400>  380

Ser Met Thr Thr Gly Gly Asp Tyr 
1               5               


<210>  381
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-49

<400>  381

Ser Thr Phe Ser Ile Gly Ala Met Gly 
1               5                   


<210>  382
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-49

<400>  382

Thr Ile Thr Ser Ser Gly Thr Thr Ser 
1               5                   


<210>  383
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-49

<400>  383

Asn Asn Leu His Gly Gly Asp Tyr 
1               5               


<210>  384
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S1-RBD-51

<400>  384

Arg Thr Leu Ser Thr Tyr Arg Met Gly 
1               5                   


<210>  385
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S1-RBD-51

<400>  385

Ala Ile Phe Trp Ser Gly Gly His Thr Val 
1               5                   10  


<210>  386
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S1-RBD-51

<400>  386

Arg Asn Pro Ala Thr Gly Asn Tyr Asp Tyr 
1               5                   10  


<210>  387
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-1 and S2-3

<400>  387

Leu Val Leu Gly Gly Tyr Asp Met Arg 
1               5                   


<210>  388
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-1

<400>  388

Ser Ile Ser Asn Gly Gly Ser Thr Asp 
1               5                   


<210>  389
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-1

<400>  389

Arg Ser Thr Tyr Tyr Gly Ile Asp Tyr 
1               5                   


<210>  390
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-2

<400>  390

Leu Gln Phe Ser Arg Ile Thr Met Ala 
1               5                   


<210>  391
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-2

<400>  391

Thr Leu Ser Thr Arg Gly Thr Thr Asn 
1               5                   


<210>  392
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-2

<400>  392

Gly Pro Gly Tyr Lys Thr Asp Tyr 
1               5               


<210>  393

<400>  393
000

<210>  394
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-3

<400>  394

Ser Ile Thr Asn Gly Gly Asp Thr Arg 
1               5                   


<210>  395
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-3

<400>  395

His Ser Thr Tyr Tyr Gly Arg Asp Phe 
1               5                   


<210>  396
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-4 and S2-7

<400>  396

Pro Thr Phe Ser Ser Arg Thr Met Gly 
1               5                   


<210>  397
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-4

<400>  397

Thr Ile Pro Trp Trp Arg Gly Ala Leu Pro Tyr 
1               5                   10      


<210>  398
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-4

<400>  398

Ser Lys Thr Trp Ser Pro Ser Thr Gly Val Ala Thr Glu Tyr Glu Phe 
1               5                   10                  15      


<210>  399
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-5

<400>  399

Leu Thr Phe Lys Asn Tyr Ala Met Gly 
1               5                   


<210>  400
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-5

<400>  400

Thr Ile Asn Ser Ile Gly Gly Pro Ala Asn 
1               5                   10  


<210>  401
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-5

<400>  401

Glu Arg Thr Pro Ser Thr Leu Leu Ala Gly Ser Ser Asn Pro Ser Arg 
1               5                   10                  15      


Val Asp Val 
            


<210>  402
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-6

<400>  402

Gly Ile Phe Gly Gly Ser Thr Met Gly 
1               5                   


<210>  403
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-6

<400>  403

Thr Ile Ser Asn Ser Gly Ser Ala Asn 
1               5                   


<210>  404
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-6

<400>  404

His Ser Ile Tyr Tyr Gly Arg Asp Tyr 
1               5                   


<210>  405

<400>  405
000

<210>  406
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-7

<400>  406

Ala Ile Pro Trp Trp Lys Gly Ala Leu Pro Tyr 
1               5                   10      


<210>  407
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-7

<400>  407

Ser Lys Thr Trp Ser Pro Tyr Thr Asp Ala Ala Thr Glu Leu Glu Phe 
1               5                   10                  15      


<210>  408
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-9

<400>  408

Ser Thr Phe Ser Thr Tyr Gly Val Ala 
1               5                   


<210>  409
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-9

<400>  409

Ser Ile Asn Ser Trp Gly Trp Ile Asn 
1               5                   


<210>  410
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-9

<400>  410

Gln Asn Ser Arg Gly Asp Asn Tyr 
1               5               


<210>  411
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-10

<400>  411

Arg Ile Val Ser Ser Ser Ala Met Ser 
1               5                   


<210>  412
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-10

<400>  412

Val Ile Ala Ser Ser Asn Ser His Thr Tyr 
1               5                   10  


<210>  413
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-10

<400>  413

Arg Ser His Leu Thr Ile Ala Ala Trp Glu Arg Leu Lys Thr Tyr Asp 
1               5                   10                  15      


Asp 
    


<210>  414
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-11

<400>  414

Arg Thr Phe Ser Gly Ala Thr Met Gly 
1               5                   


<210>  415
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-11

<400>  415

Ser Ile Leu Trp Arg Tyr Glu Tyr Thr Asn 
1               5                   10  


<210>  416
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-11

<400>  416

Ala Ile Glu Arg Ser Gly Ile Tyr Tyr His Glu Asp Ser Asn Lys Tyr 
1               5                   10                  15      


Gln Tyr 
        


<210>  417
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-13

<400>  417

Phe Thr Met Thr Tyr Tyr Thr Met Thr 
1               5                   


<210>  418
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-13

<400>  418

Ser Ser Arg Ile Thr Gly Asn Thr Tyr 
1               5                   


<210>  419
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-13

<400>  419

Gly Arg Asn Ile Asn Tyr Tyr Thr Asn Ser Ala Gln Tyr Asp Tyr 
1               5                   10                  15  


<210>  420
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-14

<400>  420

Arg Thr Phe Ser Pro Tyr Ala Met Gly 
1               5                   


<210>  421
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-14

<400>  421

Gly Ile Gly Trp Tyr Ser Gly Thr Thr Tyr 
1               5                   10  


<210>  422
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-14

<400>  422

Ser Lys Asp Arg Tyr Gly Asn Met Asp Pro Asn Gly Val Arg Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  423
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-15

<400>  423

Arg Thr Phe Ser Trp Tyr Asn Met Ala 
1               5                   


<210>  424
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-15

<400>  424

Gly Ile Ser Leu Thr Asp Ile Ser Arg Ser Gly Gly Asn Thr Tyr 
1               5                   10                  15  


<210>  425
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-15

<400>  425

Asp Asp Arg Arg Met Pro Ala Ala Ile Met Thr Ser Val Arg Asp Tyr 
1               5                   10                  15      


Val Tyr 
        


<210>  426
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-18

<400>  426

Ser Thr Phe Ser Ser Arg Thr Met Gly 
1               5                   


<210>  427
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-18

<400>  427

Ala Ile Pro Trp Trp Ile Gly Ala Leu Pro Asn 
1               5                   10      


<210>  428
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-18

<400>  428

Ser Lys Thr Trp Ser Pro Arg Thr Asp Val Thr Glu Leu Glu Phe 
1               5                   10                  15  


<210>  429
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-22, S2-40, and S2-42

<400>  429

Arg Thr Phe Ser Trp Tyr Asn Leu Ala 
1               5                   


<210>  430
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-22

<400>  430

Gly Ile Gly Arg Ile Gly Gly Asn Ile Tyr 
1               5                   10  


<210>  431
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-22

<400>  431

Asp Asp Arg Arg Met Pro Ala Ala Ile Met Thr Ser Ala Arg Asp Tyr 
1               5                   10                  15      


Val Tyr 
        


<210>  432
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-26

<400>  432

Gly Thr Phe Ser Arg Tyr Ser Met Gly 
1               5                   


<210>  433
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-26

<400>  433

Ala Ile Ser Ser Asn Asp Lys Ala Thr Tyr 
1               5                   10  


<210>  434
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-26

<400>  434

Asp Pro Val Leu Lys Met Thr Pro Asp Ile Met Ala Ser Arg Tyr Val 
1               5                   10                  15      


Tyr 
    


<210>  435
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-33

<400>  435

Ser Ile Ala Asn Met Arg Val Met Lys 
1               5                   


<210>  436
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-33

<400>  436

Thr Met Phe Asn Pro Gly Pro Thr Met 
1               5                   


<210>  437
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-33

<400>  437

Val Asp Pro Arg Asn Tyr Glu Tyr 
1               5               


<210>  438
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-35

<400>  438

Arg Ile Ser Ser Val Glu Val Leu Gly 
1               5                   


<210>  439
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-35

<400>  439

Thr Leu Thr Arg Ala Gly Thr Thr Asn 
1               5                   


<210>  440
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-35

<400>  440

Arg Asp Leu Ile Gly Gln Asn Phe 
1               5               


<210>  441
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-36

<400>  441

Arg Ile Ala Thr Asn Tyr Val Met Asp 
1               5                   


<210>  442
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-36

<400>  442

Ser Ile Ser Asn Asp Gly Ser Thr Asn 
1               5                   


<210>  443
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-36

<400>  443

Lys His Trp Trp Phe Gly Phe Ala Lys Tyr Asp Tyr 
1               5                   10          


<210>  444
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-39

<400>  444

Ile Ile Ile Ser Arg Tyr Ala Met Asp 
1               5                   


<210>  445
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-39

<400>  445

Glu Ile Ser Ser Gly Gly Thr Thr Asn 
1               5                   


<210>  446
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-39

<400>  446

Ser Tyr Thr Thr Tyr 
1               5   


<210>  447

<400>  447
000

<210>  448
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-40

<400>  448

Gly Ile Ser Arg Ile Ala Gly Asn Thr Tyr 
1               5                   10  


<210>  449
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-40

<400>  449

Asp Asp Arg Trp Met Pro Ala Ala Thr Met Thr Ser Val Arg Asp Tyr 
1               5                   10                  15      


Val Tyr 
        


<210>  450

<400>  450
000

<210>  451
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-42

<400>  451

Gly Ile Ser Arg Thr Ala Gly Asn Thr Tyr 
1               5                   10  


<210>  452
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-42

<400>  452

Asp Asp Arg Arg Met Ala Ala Ala Thr Met Thr Ser Val Arg Asp Tyr 
1               5                   10                  15      


Val Tyr 
        


<210>  453
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-47

<400>  453

Ile Leu Asn Thr Trp Pro Met Gly 
1               5               


<210>  454
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-47

<400>  454

Gln Ile Thr Ser Gly Gly Thr Thr Asn 
1               5                   


<210>  455
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-47

<400>  455

Arg Ala Asp Arg Asp Tyr 
1               5       


<210>  456
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-57

<400>  456

Arg Ile Phe Ser Ser Tyr Ala Met Ala 
1               5                   


<210>  457
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-57

<400>  457

Thr Ile Thr Trp Ser Gly Lys Leu Thr Met 
1               5                   10  


<210>  458
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-57

<400>  458

His Glu Lys Gly Trp Lys Gln Val Ser Pro Asp Asp Val Lys Tyr 
1               5                   10                  15  


<210>  459
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-59

<400>  459

Arg Thr Ile Ser Asn Tyr Asn Met Gly 
1               5                   


<210>  460
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-59

<400>  460

Ala Ala Lys Trp Ser Asp Ile Asn Glu Ser 
1               5                   10  


<210>  461
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-59

<400>  461

Ala Gly Gly Tyr Tyr Ser Asp Asn Ile Arg Gln Thr Asp Tyr Asn Tyr 
1               5                   10                  15      


<210>  462
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of S2-62

<400>  462

Arg Thr Phe Ser Ser Ala Met Met Gly 
1               5                   


<210>  463
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of S2-62

<400>  463

Ser Ile Asp Trp Arg Tyr Gln Tyr Arg Tyr 
1               5                   10  


<210>  464
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of S2-62

<400>  464

Gln Ile Gln Arg Asp Gly Ile Tyr Tyr Tyr Glu Asp Ser Ser Lys Tyr 
1               5                   10                  15      


Gln Tyr 
        


<210>  465
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  465

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Phe Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Phe Phe Pro Pro Lys Pro Lys Asp Thr Phe Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Glu Thr Val Phe His Gln Asp Trp Glu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Val Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Pro Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  466
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  466

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  467
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  467

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  468
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary precursor secretory component

<400>  468

Met Leu Leu Phe Val Leu Thr Cys Leu Leu Ala Val Phe Pro Ala Ile 
1               5                   10                  15      


Ser Thr Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu 
            20                  25                  30          


Gly Asn Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn 
        35                  40                  45              


Arg His Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys 
    50                  55                  60                  


Ile Thr Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly 
65                  70                  75                  80  


Arg Ala Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn 
                85                  90                  95      


Ile Ala Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu 
            100                 105                 110         


Gly Ile Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser 
        115                 120                 125             


Gln Gly Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu 
    130                 135                 140                 


Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln 
145                 150                 155                 160 


Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val 
                165                 170                 175     


Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg 
            180                 185                 190         


Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn 
        195                 200                 205             


Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp 
    210                 215                 220                 


Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro 
225                 230                 235                 240 


Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His 
                245                 250                 255     


Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg 
            260                 265                 270         


Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys 
        275                 280                 285             


Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys 
    290                 295                 300                 


Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala 
305                 310                 315                 320 


Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly 
                325                 330                 335     


Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile 
            340                 345                 350         


Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala 
        355                 360                 365             


Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp 
    370                 375                 380                 


Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp 
385                 390                 395                 400 


Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu 
                405                 410                 415     


Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr 
            420                 425                 430         


Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu 
        435                 440                 445             


Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu 
    450                 455                 460                 


Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val 
465                 470                 475                 480 


Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys 
                485                 490                 495     


Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly 
            500                 505                 510         


Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser 
        515                 520                 525             


Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys 
    530                 535                 540                 


Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val 
545                 550                 555                 560 


Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala 
                565                 570                 575     


Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg 
            580                 585                 590         


Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu 
        595                 600                 605             


Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser 
    610                 615                 620                 


Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Ala Leu 
625                 630                 635                 640 


Val Ser Thr Leu Val Pro Leu Gly Leu Val Leu Ala Val Gly Ala Val 
                645                 650                 655     


Ala Val Gly Val Ala Arg Ala Arg His Arg Lys Asn Val Asp Arg Val 
            660                 665                 670         


Ser Ile Arg Ser Tyr Arg Thr Asp Ile Ser Met Ser Asp Phe Glu Asn 
        675                 680                 685             


Ser Arg Glu Phe Gly Ala Asn Asp Asn Met Gly Ala Ser Ser Ile Thr 
    690                 695                 700                 


Gln Glu Thr Ser Leu Gly Gly Lys Glu Glu Phe Val Ala Thr Thr Glu 
705                 710                 715                 720 


Ser Thr Thr Glu Thr Lys Glu Pro Lys Lys Ala Lys Arg Ser Ser Lys 
                725                 730                 735     


Glu Glu Ala Glu Met Ala Tyr Lys Asp Phe Leu Leu Gln Ser Ser Thr 
            740                 745                 750         


Val Ala Ala Glu Ala Gln Asp Gly Pro Gln Glu Ala 
        755                 760                 


<210>  469
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary mature secretory component

<400>  469

Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu Gly Asn 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn Arg His 
            20                  25                  30          


Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys Ile Thr 
        35                  40                  45              


Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly Arg Ala 
    50                  55                  60                  


Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn Ile Ala 
65                  70                  75                  80  


Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu Gly Ile 
                85                  90                  95      


Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser Gln Gly 
            100                 105                 110         


Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu Gly Arg 
        115                 120                 125             


Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln Lys Arg 
    130                 135                 140                 


Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val Ile Asp 
145                 150                 155                 160 


Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg Leu Asp 
                165                 170                 175     


Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn Gln Leu 
            180                 185                 190         


Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp Asp Ser 
        195                 200                 205             


Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro Glu Pro 
    210                 215                 220                 


Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His Cys Ala 
225                 230                 235                 240 


Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg Gln Ser 
                245                 250                 255     


Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys Arg Ala 
            260                 265                 270         


Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys Asp Gly 
        275                 280                 285             


Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala Gly Arg 
    290                 295                 300                 


Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly Ser Pro 
305                 310                 315                 320 


Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile Pro Arg 
                325                 330                 335     


Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala Val Leu 
            340                 345                 350         


Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp Cys Leu 
        355                 360                 365             


Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp Ser Glu 
    370                 375                 380                 


Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu Glu Glu 
385                 390                 395                 400 


Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr Ser Arg 
                405                 410                 415     


Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu Trp Arg 
            420                 425                 430         


Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu Lys Val 
        435                 440                 445             


Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val Pro Cys 
    450                 455                 460                 


His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys Lys Trp 
465                 470                 475                 480 


Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly Pro Ser 
                485                 490                 495     


Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser Leu Thr 
            500                 505                 510         


Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys Gly Val 
        515                 520                 525             


Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val Ala Val 
    530                 535                 540                 


Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala Lys Ala 
545                 550                 555                 560 


Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg Glu Ile 
                565                 570                 575     


Glu Asn Lys Ala Ile Gln Asp Pro Arg 
            580                 585 


<210>  470
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  470

Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg 
1               5                   10                  15      


Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala 
            20                  25                  30          


Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly 
        35                  40                  45              


Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala 
    50                  55                  60                  


Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile 
65                  70                  75                  80  


Lys Glu Ser Asp Trp Leu Ser Gln Ser Met Phe Thr Cys Arg Val Asp 
                85                  90                  95      


His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro 
            100                 105                 110         


Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala 
        115                 120                 125             


Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp 
    130                 135                 140                 


Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly 
145                 150                 155                 160 


Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala 
                165                 170                 175     


Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn 
            180                 185                 190         


Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser 
        195                 200                 205             


Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly Val Ala Leu His Arg 
    210                 215                 220                 


Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg 
225                 230                 235                 240 


Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser Pro Ala Asp 
                245                 250                 255     


Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys 
            260                 265                 270         


Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr 
        275                 280                 285             


Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp Asn Thr Gly 
    290                 295                 300                 


Glu Thr Tyr Thr Cys Val Val Ala His Glu Ala Leu Pro Asn Arg Val 
305                 310                 315                 320 


Thr Glu Arg Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn 
                325                 330                 335     


Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            340                 345                 


<210>  471
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  471

Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro 
        


<210>  472
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  472

Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser 
            20                  25                  30          


Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val 
        35                  40                  45              


Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln 
    50                  55                  60                  


Asn Gly Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro 
65                  70                  75                  80  


Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp 
                85                  90                  95      


Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu 
            100                 105                 110         


Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly Val Ala Leu 
        115                 120                 125             


His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu Asn 
    130                 135                 140                 


Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser Pro 
145                 150                 155                 160 


Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser Pro 
                165                 170                 175     


Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro Gly 
            180                 185                 190         


Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp Asn 
        195                 200                 205             


Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu Ala Leu Pro Asn 
    210                 215                 220                 


Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu 
225                 230                 235                 240 


Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
                245                 250                 255 


<210>  473
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  473

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  474
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  474

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  475
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  475

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Ala Ser Ser Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  476
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  476

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ala Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  477
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  477

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Ala Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  478
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  478

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Ala Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  479
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  479

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Ala Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  480
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  480

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Ala Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  481
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  481

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


<210>  482
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  482

Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 
1               5                   10                  15      


Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 
            20                  25                  30          


Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 
        35                  40                  45              


Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 
    50                  55                  60                  


Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 
65                  70                  75                  80  


Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 
                85                  90                  95      


Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 
            100                 105                 110         


Val Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 
        115                 120                 125             


Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135         


<210>  483
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  483

Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 
1               5                   10                  15      


Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 
            20                  25                  30          


Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 
        35                  40                  45              


Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 
    50                  55                  60                  


Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 
65                  70                  75                  80  


Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 
                85                  90                  95      


Ala Thr Glu Thr Cys Ala Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 
            100                 105                 110         


Val Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 
        115                 120                 125             


Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135         


<210>  484
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  484

Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 
1               5                   10                  15      


Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 
            20                  25                  30          


Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 
        35                  40                  45              


Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 
    50                  55                  60                  


Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 
65                  70                  75                  80  


Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 
                85                  90                  95      


Ala Thr Glu Thr Cys Ser Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 
            100                 105                 110         


Val Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 
        115                 120                 125             


Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135         


<210>  485
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  485

Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 
1               5                   10                  15      


Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 
            20                  25                  30          


Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 
        35                  40                  45              


Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 
    50                  55                  60                  


Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 
65                  70                  75                  80  


Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 
                85                  90                  95      


Ala Thr Glu Thr Cys Arg Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 
            100                 105                 110         


Val Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 
        115                 120                 125             


Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135         


<210>  486
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  486

Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 
1               5                   10                  15      


Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 
            20                  25                  30          


Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 
        35                  40                  45              


Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 
    50                  55                  60                  


Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 
65                  70                  75                  80  


Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 
                85                  90                  95      


Ala Thr Glu Thr Cys Tyr Ala Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 
            100                 105                 110         


Val Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 
        115                 120                 125             


Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135         


<210>  487
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  487

Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 
1               5                   10                  15      


Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 
            20                  25                  30          


Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 
        35                  40                  45              


Ala Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 
    50                  55                  60                  


Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 
65                  70                  75                  80  


Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 
                85                  90                  95      


Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 
            100                 105                 110         


Val Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 
        115                 120                 125             


Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135         


<210>  488
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  488

Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala Arg 
1               5                   10                  15      


Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp Ile 
            20                  25                  30          


Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu Asn 
        35                  40                  45              


Ile Ala Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His Leu 
    50                  55                  60                  


Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp Asn 
65                  70                  75                  80  


Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser Ala 
                85                  90                  95      


Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala Val 
            100                 105                 110         


Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala Leu 
        115                 120                 125             


Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135     


<210>  489
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  (GlyGlyGlyGlySer) can be repeated n times wherein n is an integer
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10

<400>  489

Gly Gly Gly Gly Ser 
1               5   


<210>  490
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(10)
<223>  Gly can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (12)..(20)
<223>  Ser can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(200)
<223>  GlySer sequence can be present or absent

<400>  490

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser 
                85                  90                  95      


Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser 
            100                 105                 110         


Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ser Ser Ser 
        195                 200 


<210>  491
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (5)..(40)
<223>  (GlyGlyGlySer) can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (46)..(90)
<223>  (GlyGlyGlyGlySer) can be present or absent

<400>  491

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90  


<210>  492
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (5)..(37)
<223>  (GlyGlyGlySer) can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (41)..(70)
<223>  (GlyGlySer) can be present or absent

<400>  492

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        35                  40                  45              


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    50                  55                  60                  


Gly Gly Ser Gly Gly Ser 
65                  70  


<210>  493
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (5)..(40)
<223>  (GlyGlyGlySer) can be present or absent

<400>  493

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45  


<210>  494
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  494

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  495
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  495

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  496
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  496

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  497
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  497

Gly Gly Gly Gly Ser 
1               5   


<210>  498
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  498

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  499
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  499

Gly Gly Gly Ser 
1               


<210>  500
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  500

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  501
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  501

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  502
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  502

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  503
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  503

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  504
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL1

<400>  504

Arg Ala Ser Gln Ser Val Ser 
1               5           


<210>  505
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL2

<400>  505

Ala Ser Asn Arg Ala Thr 
1               5       


<210>  506
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL3

<400>  506

Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 
1               5                   10  


<210>  507
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH1

<400>  507

Tyr Tyr Trp Ser 
1               


<210>  508
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH3

<400>  508

Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  509
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S1-13

<400>  509

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp 
            20                  25                  30          


Asp Tyr Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Tyr Ile Ser Ser Ser Gly Ser Asn Ser Tyr Tyr Glu Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Arg Val Trp Gln Gln Thr Ile Val Val Arg Gly 
            100                 105                 110         


Pro Val His Tyr Glu Tyr Trp Gly His Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  510
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S1-18

<400>  510

Met Ala Gln Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Val Ser Gly Ser 
            20                  25                  30          


Ala Phe Arg Phe Asn Arg Leu Gly Trp Tyr Arg Gln Pro Pro Gly Lys 
        35                  40                  45              


Glu Arg Glu Leu Val Ala Ser Ile Ser Ser Gly Gly Ser Thr Asn Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Ser Thr Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Asn Ile Arg Ala Asp Phe Phe Ser Ser Gly Arg Thr 
            100                 105                 110         


Gly Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  511
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S1-8

<400>  511

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Val Leu Ser 
            20                  25                  30          


Ser Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Arg Trp Asn Gly Gly Ser Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ser Pro Arg Thr Met Tyr Asp Ala Thr Tyr Tyr Tyr 
            100                 105                 110         


Ser Arg Thr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser 
    


<210>  512
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S1-RBD-13

<400>  512

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Thr Leu Thr Leu Ser 
            20                  25                  30          


Ser His Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Tyr Ile Pro Met Thr Gly Leu Pro Ile Tyr Cys Arg Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Leu Leu Gly Val Arg Ser Arg Met Cys Pro Glu Ser 
            100                 105                 110         


Val Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  513
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-12

<400>  513

Met Thr Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Pro Thr Phe Ser 
            20                  25                  30          


Ser Arg Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp 
        35                  40                  45              


Phe Val Ala Ala Met Pro Trp Trp Lys Gly Ala Leu Pro Asn Tyr Lys 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ile Asp Ser Ala Lys Asn 
65                  70                  75                  80  


Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Ser Lys Thr Trp Ser Pro Arg Thr Glu Val Ala 
            100                 105                 110         


Thr Glu His Glu Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  514
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-20

<400>  514

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Thr 
            20                  25                  30          


Tyr Tyr Thr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Ser Ser Ser Arg Ile Ser Gly Asn Thr Tyr Tyr Thr Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Val Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Gly Arg Asn Ile Pro Tyr Asp Thr Tyr Thr Asn Pro Thr 
            100                 105                 110         


Lys Tyr Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  515
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-23

<400>  515

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Ser Ala Met Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ser Ile Asp Trp Arg Tyr Gln Tyr Arg Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Cys Gln Ile Glu Arg Ser Gly Ile Tyr His Tyr Glu Asp 
            100                 105                 110         


Ser Asn Lys Tyr Gln Ser Trp Gly Gln Gly Thr Gln Val Ser Val Ser 
        115                 120                 125             


<210>  516
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-24

<400>  516

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Ser 
            20                  25                  30          


Ser His His Met Ala Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Thr Leu Ala Ser Gly Gly Asp Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Ile 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Arg Leu Trp Ala Thr Gly Phe Arg Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser 
        115                 


<210>  517
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-29

<400>  517

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Ser 
            20                  25                  30          


Ser Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Ala Cys Ile Ser Ser Gly Ser Ser Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ile Ser Lys Glu Val Gly Trp Cys Gly Arg Glu Gly Pro Ile Gly 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120             


<210>  518
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-30

<400>  518

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Tyr Arg Gln Pro Pro Gln Ala Pro Gly Asn 
        35                  40                  45              


Gln Arg Asp Leu Val Ala Phe Ile Ser Thr Thr Gly Ser Thr Asn Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Gln Ala Ile Glu Arg Ile Val Gly Tyr Val Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120     


<210>  519
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-31

<400>  519

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser 
            20                  25                  30          


Tyr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Val Val Ala Ala Ile Asp Trp Asn Gly Lys Asn Thr Tyr Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Gly Asp Val Gln Val Asn Asn Leu Gly Asp Leu Gln Met Asn Asn Leu 
                85                  90                  95      


Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Gly Tyr Leu 
            100                 105                 110         


Arg Thr Leu Ile Lys Gly Ala Ala Ala Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser 
    130         


<210>  520
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-32

<400>  520

Met Ala Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Ile Ala Asn 
            20                  25                  30          


Met Arg Val Met Lys Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Gly Thr Met Phe Asn Pro Gly Pro Thr Met Tyr Arg Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Asn Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Val Asp Pro Arg Asn Tyr Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  521
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-34

<400>  521

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Asn 
            20                  25                  30          


Thr Tyr Gly Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Leu Val Ala Gly Ile Pro Ser Ile Gly Asn Ile Asn Tyr Ala Arg Phe 
    50                  55                  60                  


Val Gln Gly Arg Phe Thr Val Ser Arg Asp Asp Gly Lys Lys Ala Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Asn Leu Gln Thr Arg Phe Gly Thr Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  522
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-37

<400>  522

Met Ala Gln Val Gln Val Met Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Gly Ile Leu Gly 
            20                  25                  30          


Gly Tyr Asp Met Arg Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu 
        35                  40                  45              


Leu Val Ala Ser Ile Ser Ser Asp Gly Ser Thr Asn Tyr Val Asp Phe 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Met Arg Ser Thr Tyr Tyr Ala Ile Asp Tyr Trp Gly Arg Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser 
        115             


<210>  523
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-44

<400>  523

Met Ala Gln Val Gln Phe Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Gly Ser Glu Phe Thr Leu Asp 
            20                  25                  30          


Asn Tyr Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Ser Cys Ile Thr Pro Arg Gly Asn Ile Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Ala Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Ser Ala Leu Tyr Asp Cys Ser Gln Arg Gln Thr 
            100                 105                 110         


Arg Phe Phe Ser Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  524
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-45

<400>  524

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser 
            20                  25                  30          


Ser Arg Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Arg Ile Ser Trp Ser Gly Arg Asn Thr Tyr Tyr Gly Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Arg Cys Ala Ala Asp Gln Gln Tyr Tyr Asn Arg Tyr Tyr Asn Asp Glu 
            100                 105                 110         


Gln Gly Tyr Ala Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  525
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-domain antibody CoV2-S2-49

<400>  525

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Thr Leu Pro 
            20                  25                  30          


Tyr Phe Thr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Ser Ser Ser Arg Ile Thr Gly Asn Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Ser Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Arg Leu Lys Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Gly Arg Asn Ile Asn Tyr Tyr Thr Asn Ser Ala Glu Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  526
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  526

His His His His His His 
1               5       


<210>  527
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  527

Asp Tyr Lys Asp Asp Asp Asp 
1               5           


<210>  528
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xpress tag

<400>  528

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  529
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avi tag

<400>  529

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  530
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Calmodulin tag

<400>  530

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  531
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polyglutamate tag

<400>  531

Glu Glu Glu Glu Glu Glu 
1               5       


<210>  532
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  532

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  533
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  533

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  534
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep tag

<400>  534

Trp Arg His Pro Gln Phe Gly Gly 
1               5               


<210>  535
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP tag II

<400>  535

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  536
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 1

<400>  536

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  537
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 3

<400>  537

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  538
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  538

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  539

<400>  539
000

<210>  540

<400>  540
000

<210>  541

<400>  541
000

<210>  542

<400>  542
000

<210>  543

<400>  543
000

<210>  544
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leucine zipper domain of Jun

<400>  544

Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
1               5                   10                  15      


Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
            20                  25                  30          


Leu Lys Gln Lys Val Met Asn 
        35                  


<210>  545
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization domain of Fos

<400>  545

Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Lys Lys 
1               5                   10                  15      


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            20                  25                  30          


Leu Glu Phe Ile Leu Ala Ala 
        35                  


<210>  546
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization domain of the SH2B adapter protein

<400>  546

Trp Arg Glu Phe Cys Glu Ser His Ala Arg Ala Ala Ala Leu Asp Phe 
1               5                   10                  15      


Ala Arg Arg Phe Arg Leu Tyr Leu Ala Ser His Pro Gln Tyr Ala Gly 
            20                  25                  30          


Pro Gly Ala Glu Ala Ala Phe Ser Arg Arg Phe Ala Glu Leu Phe Leu 
        35                  40                  45              


Gln His Phe Glu Ala Glu Val Ala Arg Ala Ser 
    50                  55                  


<210>  547
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SH3 domain of IB1

<400>  547

Thr His Arg Ala Ile Phe Arg Phe Val Pro Arg His Glu Asp Glu Leu 
1               5                   10                  15      


Glu Leu Glu Val Asp Asp Pro Leu Leu Val Glu Leu Gln Ala Glu Asp 
            20                  25                  30          


Tyr Trp Tyr Glu Ala Tyr Asn Met Arg Thr Gly Ala Arg Gly Val Phe 
        35                  40                  45              


Pro Ala Tyr Tyr Ala Ile Glu 
    50                  55  


<210>  548
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  548

Leu Gly Glu Val His Arg Phe His Val Thr Val Ala Pro Gly Thr Lys 
1               5                   10                  15      


Leu Glu Ser Gly Pro Ala Thr Leu His Leu Cys Asn Asp Val Leu Val 
            20                  25                  30          


Leu Ala Arg Asp Ile Pro Pro Ala Val Thr Gly Gln Trp Lys Leu Ser 
        35                  40                  45              


Asp Leu Arg Arg Tyr Gly Ala Val Pro Ser Gly Phe Ile Phe Glu Gly 
    50                  55                  60                  


Gly Thr Arg Cys Gly Tyr Trp Ala Gly Val Phe Phe Leu Ser Ser Ala 
65                  70                  75                  80  


Glu Gly Glu Gln Ile Ser Phe Leu Phe Asp Cys Ile Val Arg Gly Ile 
                85                  90                  95      


Ser Pro Thr Lys Gly 
            100     


<210>  549
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDZ-like domain of SATB1

<400>  549

Asp Cys Lys Glu Glu His Ala Glu Phe Val Leu Val Arg Lys Asp Met 
1               5                   10                  15      


Leu Phe Asn Gln Leu Ile Glu Met Ala Leu Leu Ser Leu Gly Tyr Ser 
            20                  25                  30          


His Ser Ser Ala Ala Gln Ala Lys Gly Leu Ile Gln Val Gly Lys Trp 
        35                  40                  45              


Asn Pro Val Pro Leu Ser Tyr Val Thr Asp Ala Pro Asp Ala Thr Val 
    50                  55                  60                  


Ala Asp Met Leu Gln Asp Val Tyr His Val Val Thr Leu Lys Ile Gln 
65                  70                  75                  80  


Leu His Ser Cys Pro Lys Leu Glu Asp Leu Pro Pro Glu Gln Trp Ser 
                85                  90                  95      


His Thr Thr Val Arg Asn Ala Leu Lys Asp Leu Leu Lys Asp Met Asn 
            100                 105                 110         


Gln Ser Ser 
        115 


<210>  550
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WD40 repeats of APAF

<400>  550

Cys Ala Pro Trp Pro Met Val Glu Lys Leu Ile Lys Gln Cys Leu Lys 
1               5                   10                  15      


Glu Asn Pro Gln Glu Arg Pro Thr Ser Ala Gln Val Phe Asp Ile Leu 
            20                  25                  30          


Asn Ser Ala Glu Leu Val Cys Leu Thr Arg Arg Ile Leu Leu Pro Lys 
        35                  40                  45              


Asn Val Ile Val Glu Cys Met Val Ala Thr His His Asn Ser Arg Asn 
    50                  55                  60                  


Ala Ser Ile Trp Leu Gly Cys Gly His Thr Asp Arg Gly Gln Leu Ser 
65                  70                  75                  80  


Phe Leu Asp Leu Asn Thr Glu Gly Tyr Thr Ser Glu Glu Val Ala Asp 
                85                  90                  95      


Ser Arg Ile Leu Cys Leu Ala Leu Val His Leu Pro Val Glu Lys Glu 
            100                 105                 110         


Ser Trp Ile Val Ser Gly Thr Gln Ser Gly Thr Leu Leu Val Ile Asn 
        115                 120                 125             


Thr Glu Asp Gly Lys Lys Arg His Thr Leu Glu Lys Met Thr Asp Ser 
    130                 135                 140                 


Val Thr Cys Leu Tyr Cys Asn Ser Phe Ser Lys Gln Ser Lys Gln Lys 
145                 150                 155                 160 


Asn Phe Leu Leu Val Gly Thr Ala Asp Gly Lys Leu Ala Ile Phe Glu 
                165                 170                 175     


Asp Lys Thr Val Lys Leu Lys Gly Ala Ala Pro Leu Lys Ile Leu Asn 
            180                 185                 190         


Ile Gly Asn Val Ser Thr Pro Leu Met Cys Leu Ser Glu Ser Thr Asn 
        195                 200                 205             


Ser Thr Glu Arg Asn Val Met Trp Gly Gly Cys Gly Ser Gln Leu Phe 
    210                 215                 220                 


Ser Tyr Ala Ala Phe Ser Asp Ser Asn Ile Ile Thr Val Val Val Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Ile Ala Lys Gln Asn Ser Pro Val Val Glu Val Trp 
                245                 250                 255     


Asp Lys Lys Thr Glu Lys Leu Cys Gly Leu Ile Asp Cys Val His Phe 
            260                 265                 270         


Leu Arg Glu Val Met Val Lys Glu Thr Lys Ile Phe Ser Phe Ser Asn 
        275                 280                 285             


Asp Phe Thr Ile Gln Lys Leu Ile Glu Thr Arg Thr Asn Lys Glu Ser 
    290                 295                 300                 


Lys His Lys Met Ser Tyr Ser Gly Arg Val Lys Thr Leu Cys Leu Gln 
305                 310                 315                 320 


Lys Asn Thr Ala Leu Trp Ile Gly Thr Gly Gly Gly His Ile Leu Leu 
                325                 330                 335     


Leu Asp Leu Ser Thr Arg Arg Leu Ile Arg Val Ile Tyr Asn Phe Cys 
            340                 345                 350         


Asn Ser Val Arg Val Met Met Thr Ala Gln Leu Gly Ser Leu Lys Asn 
        355                 360                 365             


Val Met Leu Val Leu Gly Tyr Asn Arg Lys Asn Thr Glu Gly Thr Gln 
    370                 375                 380                 


Lys Gln Lys Glu Ile Gln Ser Cys Leu Thr Val Trp Asp Ile Asn Leu 
385                 390                 395                 400 


Pro His Glu Val Gln Asn Leu Glu Lys His Ile Glu Val Arg Lys Glu 
                405                 410                 415     


Leu Ala Glu Lys Met Arg Arg Thr Ser Val Glu 
            420                 425         


<210>  551
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS motif of the dioxin receptor

<400>  551

Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
1               5                   10                  15      


Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
            20                  25                  30          


Val Thr Pro Val Leu Asn Gln Gln Gln Ser Glu Trp Phe Gly Ser Thr 
        35                  40                  45              


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    50                  55                  60                  


Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg 
65                  70                  75  


<210>  552
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EF hand motif of parvalbumin

<400>  552

Leu Ser Ala Lys Glu Thr Lys Met Leu Met Ala Ala Gly Asp Lys Asp 
1               5                   10                  15      


Gly Asp Gly Lys Ile Gly Val Asp Glu Phe Ser Thr Leu Val Ala Glu 
            20                  25                  30          


Ser 
    


<210>  553
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization and docking domain 1

<400>  553

Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210>  554
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization and docking domain 2

<400>  554

Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly 
1               5                   10                  15      


Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe 
            20                  25                  30          


Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  45  


<210>  555
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anchoring domain 1

<400>  555

Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210>  556
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anchoring domain 2

<400>  556

Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210>  557
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FK-binding protein 12 (FKBP12)

<400>  557

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Trp His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Pro Phe Lys Phe Met 
        35                  40                  45              


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
    50                  55                  60                  


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
65                  70                  75                  80  


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
                85                  90                  95      


Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105     


<210>  558
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12-Rapamycin Binding (FRB) domain

<400>  558

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  559
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-1 peptide

<400>  559

Asp Asn Ala Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro 
1               5                   10                  15      


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Ser Lys 
            20                  25                  


<210>  560
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-1, S1-23, and S1-RBD-15 peptide

<400>  560

Gln Ala Pro Gly Lys Glu Arg 
1               5           


<210>  561
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-1 peptide

<400>  561

Thr Ala Ser Arg Asp Asn Ala Lys Asn 
1               5                   


<210>  562
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-1 peptide

<400>  562

Leu Ala Asp Ser Val Lys Gly Arg Phe 
1               5                   


<210>  563
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-1 peptide

<400>  563

Thr Ala Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
1               5                   10          


<210>  564
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-1 peptide

<400>  564

Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
1               5                   10                  


<210>  565
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-1 peptide

<400>  565

Tyr Cys Ala Ala Asp Ser Lys Gly Trp 
1               5                   


<210>  566
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-23 peptide

<400>  566

Glu Asp Ser Val Lys Gly Arg Phe 
1               5               


<210>  567
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-23 peptide

<400>  567

Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
1               5                   10  


<210>  568
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-23 peptide

<400>  568

Gln Met Asn Ser Leu Lys Pro Glu 
1               5               


<210>  569
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-23 peptide

<400>  569

Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
1               5                   10          


<210>  570
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-23 peptide

<400>  570

Lys Pro Glu Asp Thr Ala Val Tyr 
1               5               


<210>  571
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-RBD-15 peptide

<400>  571

Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
1               5                   10          


<210>  572
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-RBD-15 peptide

<400>  572

Thr Ile Ser Arg Asp Asn Ala Lys Asn 
1               5                   


<210>  573
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  573

Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
1               5                   10                  15      


<210>  574
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  574

Lys Ser Asn Leu Lys Pro Phe Glu Arg 
1               5                   


<210>  575
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  575

Ser Asn Leu Lys Pro Phe Glu Arg 
1               5               


<210>  576
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  576

Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
1               5                   10          


<210>  577
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  577

Arg Lys Ser Asn Leu Lys Pro Phe 
1               5               


<210>  578
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  578

Ser Lys Val Gly Gly Asn Tyr 
1               5           


<210>  579
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  579

Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
1               5                   10              


<210>  580
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  580

Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
1               5                   10                  15      


Lys Ile Ala Asp Tyr 
            20      


<210>  581
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  581

Gly Val Ser Pro Thr Lys Leu 
1               5           


<210>  582
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  582

Arg Lys Ser Asn Leu Lys Pro Phe 
1               5               


<210>  583
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  583

Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr 
1               5                   10      


<210>  584
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  584

Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
1               5                   10              


<210>  585
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  585

Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr 
1               5                   10                  15      


<210>  586
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD peptide

<400>  586

Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
1               5                   10          


<210>  587
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  587

Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  588
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  588

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp 
        35                  40                  45              


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            100                 105                 110         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn 
145                 150                 155                 160 


Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         


Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr 
        195                 200                 205             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             


<210>  589
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  589

Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
        35                  40                  45              


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
        115                 120                 125             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
            180                 185                 190         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215             


<210>  590
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer 6N_CALL001


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  n is a, c, g, or t

<400>  590
nnnnnngtcc tggctgctct tctacaagg                                         29


<210>  591
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer 6N_CALL001B


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  n is a, c, g, or t

<400>  591
nnnnnngtcc tggctgctct tttacaagg                                         29


<210>  592
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer 6N_VHH_SH_rev


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  n is a, c, g, or t

<400>  592
nnnnnnctgg ggtcttcgct gtggtgc                                           27


<210>  593
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer 6N_VHH_LH_rev


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  n is a, c, g, or t

<400>  593
nnnnnngtgg ttgtggtttt ggtgtcttgg g                                      31


<210>  594
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin-binding domain

<400>  594

Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Glu Ala Ala Ile Asn 
1               5                   10                  15      


Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val Thr Leu Ile Asn 
            20                  25                  30          


Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Ala Glu Ile Leu 
        35                  40                  45              


Ser Ala Leu Pro 
    50          


<210>  595
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin-binding domain

<400>  595

Leu Lys Glu Ala Lys Glu Lys Ala Ile Glu Glu Leu Lys Lys Ala Gly 
1               5                   10                  15      


Ile Thr Ser Asp Tyr Tyr Phe Asp Leu Ile Asn Lys Ala Lys Thr Val 
            20                  25                  30          


Glu Gly Val Asn Ala Leu Lys Asp Glu Ile Leu Lys Ala 
        35                  40                  45  


