                         SEQUENCE LISTING

<110>  PRECISION BIOSCIENCES, INC.
 
<120>  ENGINEERED MEGANUCLEASES HAVING SPECIFICITY FOR A RECOGNITION 
       SEQUENCE IN THE TRANSTHYRETIN GENE

<130>  P1090.70034WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/068,965
<151>  2020-08-21

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  163
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  1

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser 
            20                  25                  30          


Tyr Lys Phe Lys His Gln Leu Ser Leu Ala Phe Gln Val Thr Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Trp Arg Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys 
145                 150                 155                 160 


Ser Ser Pro 
            


<210>  2
<211>  9
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  2

Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210>  3
<211>  7258
<212>  DNA
<213>  Homo sapiens

<400>  3
gttgactaag tcaataatca gaatcagcag gtttgcagtc agattggcag ggataagcag       60

cctagctcag gagaagtgag tataaaagcc ccaggctggg agcagccatc acagaagtcc      120

actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg ctggactggt      180

atttgtgtct gaggctggcc ctacggtgag tgtttctgtg acatcccatt cctacattta      240

agattcacgc taaatgaagt agaagtgact ccttccagct ttgccaacca gcttttatta      300

ctagggcaag ggtacccagc atctattttt aatataatta attcaaactt caaaaagaat      360

gaagttccac tgagcttact gagctgggac ttgaactctg agcattctac ctcattgctt      420

tggtgcatta ggtttgtaat atctggtacc tctgtttcct cagatagatg atagaaataa      480

agatatgata ttaaggaagc tgttaatact gaattttcag aaaagtatcc ctccataaaa      540

tgtatttggg ggacaaactg caggagatta tattctggcc ctatagttat tcaaaacgta      600

tttattgatt aatctttaaa aggcttagtg aacaatattc tagtcagata tctaattctt      660

aaatcctcta gaagaattaa ctaatactat aaaatgggtc tggatgtagt tctgacatta      720

ttttataaca actggtaaga gggagtgact atagcaacaa ctaaaatgat ctcaggaaaa      780

cctgtttggc cctatgtatg gtacattaca tcttttcagt aattccactc aaatggagac      840

ttttaacaaa gcaactgttc tcaggggacc tattttctcc cttaaaattc attatacaca      900

tccctggttg atagcagtgt gtctggaggc agaaaccatt cttgctttgg aaacaattac      960

gtctgtgtta tactgagtag ggaagctcat taattgtcga cacttacgtt cctgataatg     1020

ggatcagtgt gtaattcttg tttcgctcca gatttctaat accacaaaga ataaatcctt     1080

tcactctgat caattttgtt aacttctcac gtgtcttctc tacacccagg gcaccggtga     1140

atccaagtgt cctctgatgg tcaaagttct agatgctgtc cgaggcagtc ctgccatcaa     1200

tgtggccgtg catgtgttca gaaaggctgc tgatgacacc tgggagccat ttgcctctgg     1260

gtaagttgcc aaagaaccct cccacaggac ttggttttat cttcccgttt gcccctcact     1320

tggtagagag aggctcacat catctgctaa agaatttaca agtagattga aaaacgtagg     1380

cagaggtcaa gtatgccctc tgaaggatgc cctctttttg ttttgcttag ctaggaagtg     1440

accaggaacc tgagcatcat ttaggggcag acagtagaga aaagaaggaa tcagaactcc     1500

tctcctctag ctgtggtttg caaccctttt gggtcacaga acactttatg taggtgatga     1560

aaagtaaaca ttctatgccc agaaaaaatg cacagataca cacacataca aaatcatata     1620

tgtgatttta ggagtttcac agattccctg gtgtccctgg gtaacaccaa agctaagtgt     1680

ccttgtctta gaattttagg aaaaggtata atgtgtatta acccattaac aaaaggaaag     1740

gaattcagaa atattattaa ccaggcatct gtctgtagtt aatatggatc acccaaaacc     1800

caaggctttt gcctaatgaa cactttgggg cacctactgt gtgcaaggct gggggctgtc     1860

aagctcagtt aaaaaaaaaa agatagaaga gatggatcca tgaggcaaag tacagcccca     1920

ggctaatccc acgatcaccc gacttcatgt ccaagagtgg cttctcacct tcattagcca     1980

gttcacaatt ttcatggagt ttttctacct gcactagcaa aaacttcaag gaaaatacat     2040

attaataaat ctaagcaaag tgaccagaag acagagcaat caggagaccc tttgcatcca     2100

gcagaagagg aactgctaag tatttacatc tccacagaga agaatttctg ttgggtttta     2160

attgaacccc aagaaccaca tgattcttca accattattg ggaagatcat tttcttaggt     2220

ctggttttaa ctggcttttt atttgggaat tcatttatgt ttatataaaa tgccaagcat     2280

aacatgaaaa gtggttacag gactattcta agggagagac agaatggaca ccaaaaatat     2340

tccaatgttc ttgtgaatct tttccttgca ccaggacaaa aaaaaaaaga agtgaaaaga     2400

agaaaggagg aggggcataa tcagagtcag taaagacaac tgctattttt atctatcgta     2460

gctgttgcag tcaaatggga agcaatttcc aacattcaac tatggagctg gtacttacat     2520

ggaaatagaa gttgcctagt gtttgttgct ggcaaagagt tatcagagag gttaaatata     2580

taaaagggaa aagagtcaga tacaggttct tcttcctact ttaggttttc cactgtgtgt     2640

gcaaatgata ctccctggtg gtgtgcagat gcctcaaagc tatcctcaca ccacaaggga     2700

gaggagcgag atcctgctgt cctggagaag tgcagagtta gaacagctgt ggccacttgc     2760

atccaatcat caatcttgaa tcacagggac tctttcttaa gtaaacatta tacctggccg     2820

ggcacggtgg ctcacgcctg taatcccagc actttgggat gccaaagtgg gcatatcatc     2880

tgaggtcagg agttcaagac cagcctggcc aacatggcaa aactccgtct ttatgaaaaa     2940

tacaaaaatt agccaggcat ggtggcaggc gcctgtaatc ccagctaatt gggaggctga     3000

ggctggagaa tcccttgaat ctaggaggca gaggttgcag tgagctgaga tcgtgccatt     3060

gcactccagc ctgggtgaca agagtaaaac tctgtctcaa aaaaaaaaaa ttatacctac     3120

attctcttct tatcagagaa aaaaatctac agtgagcttt tcaaaaagtt tttacaaact     3180

ttttgccatt taatttcagt taggagtttt ccctacttct gacttagttg aggggaaatg     3240

ttcataacat gtttataaca tgtttatgtg tgttagttgg tgggggtgta ttactttgcc     3300

atgccatttg tttcctccat gcgtaactta atccagactt tcacacctta taggaaaacc     3360

agtgagtctg gagagctgca tgggctcaca actgaggagg aatttgtaga agggatatac     3420

aaagtggaaa tagacaccaa atcttactgg aaggcacttg gcatctcccc attccatgag     3480

catgcagagg tgagtataca gaccttcgag ggttgttttg gttttggttt ttgcttttgg     3540

cattccagga aatgcacagt tttactcagt gtaccacaga aatgtcctaa ggaaggtgat     3600

gaatgaccaa aggttccctt tcctattata caagaaaaaa ttcacaacac tctgagaagc     3660

aaatttcttt ttgactttga tgaaaatcca cttagtaaca tgacttgaac ttacatgaaa     3720

ctactcatag tctattcatt ccactttata tgaatattga tgtatctgct gttgaaataa     3780

tagtttatga ggcagccctc cagaccccac gtagagtgta tgtaacaaga gatgcaccat     3840

tttatttctc gaaaacccgt aacattcttc attccaaaac acatctggct tctcggaggt     3900

ctggacaagt gattcttggc aacacatacc tatagagaca ataaaatcaa agtaataatg     3960

gcaacacaat agataacatt taccaagcat acaccatgtg gcagacacaa ttataagtgt     4020

tttccatatt taacctactt aatcctcagg aataagccac tgaggtcagt cctattatta     4080

tccccatctt atagatgaag aaaatgaggc accaggaagt caaataactt gtcaaaggtc     4140

acaagactag gaaatacaca agtagaaatg tttacaatta aggcccaggc tgggtttgcc     4200

ctcagttctg ctatgcctcg cattatgccc caggaaactt tttcccttgt gaaagccaag     4260

cttaaaaaaa gaaaagccac atttgtaacg tgctctgttc ccctgcctat ggtgaggatc     4320

ttcaaacagt tatacatgga cccagtcccc ctgccttctc cttaatttct taagtcattt     4380

gaaacagatg gctgtcatgg aaatagaatc cagacatgtt ggtcagagtt aaagatcaac     4440

taattccatc aaaaatagct cggcatgaaa gggaactatt ctctggctta gtcatggatg     4500

agactttcaa ttgctataaa gtggttcctt tattagacaa tgttaccagg gaaacaacag     4560

gggtttgttt gacttctggg gcccacaagt caacaagaga gccccatcta ccaaggagca     4620

tgtccctgac tacccctcag ccagcagcaa gacatggacc ccagtcaggg caggagcagg     4680

gtttcggcgg cgcccagcac aagacattgc ccctagagtc tcagccccta ccctcgagta     4740

atagatctgc ctacctgaga ctgttgtttg cccaagagct gggtctcagc ctgatgggaa     4800

ccatataaaa aggttcactg acatactgcc cacatgttgt tctctttcat tagatcttag     4860

cttccttgtc tgctcttcat tcttgcagta ttcattcaac aaacattaaa aaaaaaaaaa     4920

agcattctat gtgtggaaca ctctgctaga tgctgtggat ttagaaatga aaatacatcc     4980

cgacccttgg aatggaaggg aaaggactga agtaagacag attaagcagg accgtcagcc     5040

cagcttgaag cccagataaa tacggagaac aagagagagc gagtagtgag agatgagtcc     5100

caatgcctca ctttggtgac gggtgcgtgg tgggcttcat gcagcttctt ctgataaatg     5160

cctccttcag aactggtcaa ctctaccttg gccagtgacc caggtggtca tagtagattt     5220

accaagggaa aatggaaact tttattagga gctcttaggc ctcttcactt catggatttt     5280

tttttccttt ttttttgaga tggagttttg ccctgtcacc caggctggaa tgcagtggtg     5340

caatctcagc tcactgcaac ctccgcctcc caggttcaag caattctcct gcctcagcct     5400

cccgagtagc tgggactaca ggtgtgcgcc accacaccag gctaattttt gtattttttg     5460

taaagacagg ttttcaccac gttggccagg ctggtctgaa ctccagacct caggtgattc     5520

acctgtctca gcctcccaaa gtgctgggat tacaggtgtg agccaccgtg cccggctact     5580

tcatggattt ttgattacag attatgcctc ttacaatttt taagaagaat caagtgggct     5640

gaaggtcaat gtcaccataa gacaaaagac atttttatta gttgattcta gggaattggc     5700

cttaagggga gccctttctt cctaagagat tcttaggtga ttctcacttc ctcttgcccc     5760

agtattattt ttgtttttgg tatggctcac tcagatcctt ttttcctcct atccctaagt     5820

aatccgggtt tctttttccc atatttagaa caaaatgtat ttatgcagag tgtgtccaaa     5880

cctcaaccca aggcctgtat acaaaataaa tcaaattaaa cacatcttta ctgtcttcta     5940

cctctttcct gacctcaata tatcccaact tgcctcactc tgagaaccaa ggctgtccca     6000

gcacctgagt cgcagatatt ctactgattt gacagaactg tgtgactatc tggaacagca     6060

ttttgatcca caatttgccc agttacaaag cttaaatgag ctctagtgca tgcatatata     6120

tttcaaaatt ccaccatgat cttccacact ctgtattgta aatagagccc tgtaatgctt     6180

ttacttcgta tttcattgct tgttatacat aaaaatatac ttttcttctt catgttagaa     6240

aatgcaaaga ataggagggt gggggaatct ctgggcttgg agacaggaga cttgccttcc     6300

tactatggtt ccatcagaat gtagactggg acaatacaat aattcaagtc tggtttgctc     6360

atctgtaaat tgggaagaat gtttccagct ccagaatgct aaatctctaa gtctgtggtt     6420

ggcagccact attgcagcag ctcttcaatg actcaatgca gttttgcatt ctccctacct     6480

tttttttcta aaaccaataa aatagataca gcctttaggc tttctgggat ttcccttagt     6540

caagctaggg tcatcctgac tttcggcgtg aatttgcaaa acaagacctg actctgtact     6600

cctgctctaa ggactgtgca tggttccaaa ggcttagctt gccagcatat ttgagctttt     6660

tccttctgtt caaactgttc caaaatataa aagaataaaa ttaattaagt tggcactgga     6720

cttccggtgg tcagtcatgt gtgtcatctg tcacgttttt cgggctctgg tggaaatgga     6780

tctgtctgtc ttctctcata ggtggtattc acagccaacg actccggccc ccgccgctac     6840

accattgccg ccctgctgag cccctactcc tattccacca cggctgtcgt caccaatccc     6900

aaggaatgag ggacttctcc tccagtggac ctgaaggacg agggatggga tttcatgtaa     6960

ccaagagtat tccattttta ctaaagcagt gttttcacct catatgctat gttagaagtc     7020

caggcagaga caataaaaca ttcctgtgaa aggcactttt cattccactt taacttgatt     7080

ttttaaattc ccttattgtc ccttccaaaa aaaagagaat caaaatttta caaagaatca     7140

aaggaattct agaaagtatc tgggcagaac gctaggagag atccaaattt ccattgtctt     7200

gcaagcaaag cacgtattaa atatgatctg cagccattaa aaagacacat tctgtaaa       7258


<210>  4
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  5
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125         


<210>  6
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Met His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125         


<210>  7
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  7
tgcatgggct cacaactgag ga                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  8
acgtacccga gtgttgactc ct                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  9
gctggactgg tatttgtgtc tg                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  10
cgacctgacc ataaacacag ac                                                22


<210>  11
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ala Asp Gly Ser Ile Tyr Ala Cys Ile Thr Pro Arg Gln Thr 
            20                  25                  30          


His Lys Phe Lys His Val Leu Ala Leu Gly Phe Ser Val Ile Gln Arg 
        35                  40                  45              


Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Asp Thr Thr Ser Glu Tyr Arg Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Asp Pro Asp Gln Arg Ser 
    210                 215                 220                 


Lys Phe Lys His Gly Leu Arg Leu Asn Phe Gln Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Gln Asp Lys Gly Ser Val Ser His Tyr Ile Leu Ser Gln Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  12
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ala Asp Gly Ser Ile Tyr Ala Cys Ile Thr Pro Arg Gln Asp 
            20                  25                  30          


Tyr Lys Phe Lys His Asn Leu Ala Leu Gly Phe Ser Val Ile Gln Arg 
        35                  40                  45              


Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Asp Thr Thr Ser Glu Tyr Arg Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Asp Pro Asp Gln Arg Ser 
    210                 215                 220                 


Lys Phe Lys His Gly Leu Arg Leu Asn Phe Gln Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Gln Asp Lys Gly Ser Val Ser His Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  13
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ala Asp Gly Ser Ile Tyr Ala Cys Ile Thr Pro Arg Gln Leu 
            20                  25                  30          


Cys Lys Phe Lys His Gly Leu Ala Leu Gly Phe Ser Val Ile Gln Arg 
        35                  40                  45              


Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Asp Thr Thr Ser Glu Tyr Arg Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Asp Pro Asp Gln Arg Ser 
    210                 215                 220                 


Lys Phe Lys His Gly Leu Arg Leu Asn Phe Gln Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Gln Asp Lys Gly Ser Val Ser His Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  14
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ala Asp Gly Ser Ile Tyr Ala Cys Ile Thr Pro Arg Gln Thr 
            20                  25                  30          


His Lys Phe Lys His Asn Leu Ala Leu Gly Phe Ser Val Ile Gln Arg 
        35                  40                  45              


Thr Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Asp Thr Thr Ser Glu Tyr Arg Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Asp Pro Asp Gln Arg Ser 
    210                 215                 220                 


Lys Phe Lys His Gly Leu Arg Leu Asn Phe Gln Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Gln Asp Lys Gly Ser Val Ser His Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  15
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Phe Ala Ser Ile Glu Pro Ala Gln Arg 
            20                  25                  30          


Ala Lys Phe Lys His Tyr Leu Arg Leu Val Phe Asn Val Thr Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Ser Asp Ser Gly Ser Val Ser Leu Tyr Lys Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Phe Ala Ser Ile Val Pro Asp Gln Ser Arg 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Arg Leu Arg Phe Ile Val Ser Gln Asn Thr 
225                 230                 235                 240 


Arg Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Lys Asp Ser Gly Arg Ser Ala His Tyr Thr Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  16
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Thr Pro Arg Gln Thr His Lys Phe Lys His Val 
            20                  25                  30          


Leu Ala Leu Gly Phe Ser Val Ile Gln Arg Thr Arg Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Arg 
    50                  55                  60                  


Asp Thr Thr Ser Glu Tyr Arg Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  17
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Thr Pro Arg Gln Asp Tyr Lys Phe Lys His Asn 
            20                  25                  30          


Leu Ala Leu Gly Phe Ser Val Ile Gln Arg Thr Arg Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Arg 
    50                  55                  60                  


Asp Thr Thr Ser Glu Tyr Arg Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  18
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Thr Pro Arg Gln Leu Cys Lys Phe Lys His Gly 
            20                  25                  30          


Leu Ala Leu Gly Phe Ser Val Ile Gln Arg Thr Arg Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Arg 
    50                  55                  60                  


Asp Thr Thr Ser Glu Tyr Arg Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  19
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Thr Pro Arg Gln Thr His Lys Phe Lys His Asn 
            20                  25                  30          


Leu Ala Leu Gly Phe Ser Val Ile Gln Arg Thr Arg Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Arg 
    50                  55                  60                  


Asp Thr Thr Ser Glu Tyr Arg Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  20
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Asp Pro Asp Gln Arg Ser Lys Phe Lys His Gly 
            20                  25                  30          


Leu Arg Leu Asn Phe Gln Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Gln Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Ile Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  21
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Asp Pro Asp Gln Arg Ser Lys Phe Lys His Gly 
            20                  25                  30          


Leu Arg Leu Asn Phe Gln Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Gln Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Ile Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  22
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Asp Pro Asp Gln Arg Ser Lys Phe Lys His Gly 
            20                  25                  30          


Leu Arg Leu Asn Phe Gln Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Gln Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Ile Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  23
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Asp Pro Asp Gln Arg Ser Lys Phe Lys His Gly 
            20                  25                  30          


Leu Arg Leu Asn Phe Gln Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Gln Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Ile Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  24
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Ser Ile Glu Pro Ala Gln Arg Ala Lys Phe Lys His Tyr 
            20                  25                  30          


Leu Arg Leu Val Phe Asn Val Thr Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Ser Asp Ser 
    50                  55                  60                  


Gly Ser Val Ser Leu Tyr Lys Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  25
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ser Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Ser Ile Val Pro Asp Gln Ser Arg Lys Phe Lys His Ala 
            20                  25                  30          


Leu Arg Leu Arg Phe Ile Val Ser Gln Asn Thr Arg Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Lys Asp Ser 
    50                  55                  60                  


Gly Arg Ser Ala His Tyr Thr Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  26
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  26
tgcatgggc                                                                9


<210>  27
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  27
acgtacccg                                                                9


<210>  28
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  28
aactgagga                                                                9


<210>  29
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  29
ttgactcct                                                                9


<210>  30
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  30
gctggactg                                                                9


<210>  31
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  31
cgacctgac                                                                9


<210>  32
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  32
ttgtgtctg                                                                9


<210>  33
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  33
aacacagac                                                                9


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  34
cactggactg gtatttgtgt ctga                                              24


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  35
tgctggactg gtatttgtgt ctga                                              24


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  36
ccactcattc ttggcaggat                                                   20


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  37
cacagaaaca ctcaccgtag g                                                 21


<210>  38
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  38
aaattcctcc tcagttgtga gccc                                              24


<210>  39
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  39
agtctggaga gctgcat                                                      17


<210>  40
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  40
ccagtaagat ttggtgtcta tttc                                              24


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  41
atgggctcac aactgaggag gaat                                              24


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  42
tccagacttt cacaccttat ag                                                22


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  43
tccactttgt atatcccttc tac                                               23


<210>  44
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  44
tgctggactg gtatttgtgt ctga                                              24


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  45
ccactcattc ttggcaggat                                                   20


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  46
cacagaaaca ctcaccgtag g                                                 21


<210>  47
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  47
gtgtctgtct gcacatttc                                                    19


<210>  48
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  48
agaaggcact tcttctttat ct                                                22


<210>  49
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  49
cctcgctgga ctggtatttg tgtct                                             25


<210>  50
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  50
tccgatactc taatctccct aggcaagg                                          28


<210>  51
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  51
agtctggaga gctgcat                                                      17


<210>  52
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  52
ccagtaagat ttggtgtcta tttc                                              24


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  53
cctcagttgt gagcccatg                                                    19


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  54
ccactcgttc ttggcaggat                                                   20


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  55
cacagaaaca ctcaccgtag g                                                 21


<210>  56
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  56
tgctggactg gtatttgtgt ctga                                              24


<210>  57
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  57
ggatccgtgg gaggtctat                                                    19


<210>  58
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  58
acctgctcca gctctga                                                      17


<210>  59
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  59
tgcttcggag atccctgaac cc                                                22


<210>  60
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  60
accgccaagg atgcac                                                       16


<210>  61
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  61
gcgggtggga atggag                                                       16


<210>  62
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  62
ccagcaggcc aggtacacc                                                    19


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  63
gccatgccat ttgtttcctc catg                                              24


<210>  64
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  64
gcatgctcat ggaatggg                                                     18


<210>  65
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  65

Ser Leu Pro Gly Ser Val Gly Gly Leu Ser Pro Ser Gln Ala Ser Ser 
1               5                   10                  15      


Ala Ala Ser Ser Ala Ser Ser Ser Pro Gly Ser Gly Ile Ser Glu Ala 
            20                  25                  30          


Leu Arg Ala Gly Ala Gly Ser Gly Thr Gly 
        35                  40          


<210>  66
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  66
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacgctgac       60

ggttccatct atgcctgtat cacgcctcgt caaactcata agttcaagca cgttctggcg      120

ctcgggttct cagtcattca gcgtacacgt cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gcgtgacagg gatacgacca gcgaatacag actgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaggacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgccag tatcgatcct      660

gatcaacgga gtaagttcaa gcacgggctg aggctcaatt tccaggtctc tcagaagaca      720

cagcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcaggac      780

aagggcagcg tctcccatta cattctgtcc cagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cctaa                     1065


<210>  67
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  67
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacgctgac       60

ggttccatct atgcctgtat cacgcctcgt caagattata agttcaagca caatctggcg      120

ctcgggttca gtgtcattca gcgtacacgt cgccgttggt tccttgacaa gctggtggac      180

gagatcggtg tgggttacgt gcgtgacagg gatacgacca gcgaatacag actgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaggacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgccag tatcgatcct      660

gatcaacgga gtaagttcaa gcacgggctg aggctcaatt tccaggtctc tcagaagaca      720

cagcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcaggac      780

aagggcagcg tctcccatta cattctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cctaa                     1065


<210>  68
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  68
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacgctgac       60

ggttccatct atgcctgtat cacgcctcgt caactttgta agttcaagca cgggctggcg      120

ctcgggttct cggtcattca gcgtacacgt cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gcgtgacagg gatacgacca gcgaatacag actgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaggacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgccag tatcgatcct      660

gatcaacgga gtaagttcaa gcacgggctg aggctcaatt tccaggtctc tcagaagaca      720

cagcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcaggac      780

aagggcagcg tctcccatta cattctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cctaa                     1065


<210>  69
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  69
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacgctgac       60

ggttccatct atgcctgtat cacgcctcgt caaacgcata agttcaagca caatctggcg      120

ctcgggttca gtgtcattca gcgtacacgt cgccgttggt tccttgacaa gctggtggac      180

gagatcggtg tgggttacgt gcgtgacagg gatacgacca gcgaatacag actgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaggacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgccag tatcgatcct      660

gatcaacgga gtaagttcaa gcacgggctg aggctcaatt tccaggtctc tcagaagaca      720

cagcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcaggac      780

aagggcagcg tctcccatta cattctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cctaa                     1065


<210>  70
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  70
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacggtgac       60

ggttccatct tcgcctccat tgaaccagcg caacgggcga agttcaagca ctatctgcgt      120

ctcgtgttca atgtcactca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtctgactct ggcagcgtct ccctttacaa gctcagcgaa      240

attaaaccat tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacagc gacggctcca tctttgccag tatcgtgcct      660

gatcaatcgc gtaagttcaa gcatgctctc cggttgcgct ttattgtcag tcagaataca      720

aggcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgaaggac      780

tctggtcgga gcgcccatta tactctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cctaa                     1065


