                         SEQUENCE LISTING

<110>  A2 BIOTHERAPEUTICS, INC.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING MESOTHELIN POSITIVE CANCERS

<130>  A2BI-019/03WO 331656-2068

<140>  PCT/US2021/046751
<141>  2021-08-19

<150>  US 63/085,971
<151>  2020-09-30

<150>  US 63/068,245
<151>  2020-08-20

<160>  1255  

<170>  PatentIn version 3.5

<210>  1
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  2
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  3
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Asp Ile Val Met Thr Gln Ser Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
145                 150                 155                 160 


Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr 
    210                 215                 220                 


Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
225                 230                 235         


<210>  4
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Ala Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Arg Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Arg Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ala Ser Cys Gly Gly Asp Cys Tyr Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Glu Asn Val Asn Ile Trp Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ser Ser Ser 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Gln Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  5
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Gly Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  6
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Glu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  7
<211>  45
<212>  PRT
<213>  Unknown

<220>  
<223>  CD8alpha hinge

<400>  7

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  8
<211>  135
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes CD8alpha hinge

<400>  8
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  9
<211>  41
<212>  PRT
<213>  Unknown

<220>  
<223>  CD28 hinge

<400>  9

Cys Thr Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
1               5                   10                  15      


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40      


<210>  10
<211>  123
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes CD28 hinge

<400>  10
tgtaccattg aagttatgta tcctcctcct tacctagaca atgagaagag caatggaacc       60

attatccatg tgaaagggaa acacctttgt ccaagtcccc tatttcccgg accttctaag      120

ccc                                                                    123


<210>  11
<211>  27
<212>  PRT
<213>  Unknown

<220>  
<223>  CD28 transmembrane domain

<400>  11

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  12
<211>  81
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes CD28 transmembrane domain

<400>  12
ttctgggtgc tggtcgttgt gggcggcgtg ctggcctgct acagcctgct ggtgacagtg       60

gccttcatca tcttttgggt g                                                 81


<210>  13
<211>  25
<212>  PRT
<213>  Unknown

<220>  
<223>  IL-2Rbeta transmembrane domain

<400>  13

Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210>  14
<211>  75
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes IL-2Rbeta transmembrane domain

<400>  14
attccgtggc tcggccacct cctcgtgggc ctcagcgggg cttttggctt catcatctta       60

gtgtacttgc tgatc                                                        75


<210>  15
<211>  112
<212>  PRT
<213>  Unknown

<220>  
<223>  CD3zeta activation domain

<400>  15

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  16
<211>  336
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes CD3zeta activation domain

<400>  16
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gcgtagaggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggactca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  17
<211>  43
<212>  PRT
<213>  Unknown

<220>  
<223>  CD3zeta activation domain

<400>  17

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu His Met Gln Ala Leu Pro Pro Arg 
        35                  40              


<210>  18
<211>  129
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes CD3zeta activation domain

<400>  18
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttgcacat gcaggccctg      120

ccccctcgc                                                              129


<210>  19
<211>  41
<212>  PRT
<213>  Unknown

<220>  
<223>  CD28 co-stimulatory domain

<400>  19

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  20
<211>  123
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes CD28 co-stimulatory domain

<400>  20
aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct       60

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg      120

agc                                                                    123


<210>  21
<211>  23
<212>  PRT
<213>  Unknown

<220>  
<223>  TCR alpha transmembrane domain

<400>  21

Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu Arg Leu Trp 
            20              


<210>  22
<211>  69
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes TCR alpha transmembrane domain

<400>  22
gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg       60

cggctgtgg                                                               69


<210>  23
<211>  23
<212>  PRT
<213>  Unknown

<220>  
<223>  TCR beta transmembrane domain

<400>  23

Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
1               5                   10                  15      


Leu Val Ser Ala Leu Val Leu 
            20              


<210>  24
<211>  69
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes TCR beta transmembrane domain

<400>  24
accatcctct atgagatctt gctagggaag gccaccttgt atgccgtgct ggtcagtgcc       60

ctcgtgctg                                                               69


<210>  25
<211>  10
<212>  PRT
<213>  Unknown

<220>  
<223>  TCR beta intracellular domain

<400>  25

Met Ala Met Val Lys Arg Lys Asp Ser Arg 
1               5                   10  


<210>  26
<211>  30
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes TCR beta intracellular domain

<400>  26
atggccatgg tcaagagaaa ggattccaga                                        30


<210>  27
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  28
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Glu Ala Pro Pro Leu Leu Leu Ala Ala Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Leu Val Val Leu Leu Leu Leu Leu Arg His Trp Gly Trp Gly 
            20                  25                  30          


Leu Cys Leu Ile Gly Trp Asn Glu Phe Ile Leu Gln Pro Ile His Asn 
        35                  40                  45              


Leu Leu Met Gly Asp Thr Lys Glu Gln Arg Ile Leu Asn His Val Leu 
    50                  55                  60                  


Gln His Ala Glu Pro Gly Asn Ala Gln Ser Val Leu Glu Ala Ile Asp 
65                  70                  75                  80  


Thr Tyr Cys Glu Gln Lys Glu Trp Ala Met Asn Val Gly Asp Lys Lys 
                85                  90                  95      


Gly Lys Ile Val Asp Ala Val Ile Gln Glu His Gln Pro Ser Val Leu 
            100                 105                 110         


Leu Glu Leu Gly Ala Tyr Cys Gly Tyr Ser Ala Val Arg Met Ala Arg 
        115                 120                 125             


Leu Leu Ser Pro Gly Ala Arg Leu Ile Thr Ile Glu Ile Asn Pro Asp 
    130                 135                 140                 


Cys Ala Ala Ile Thr Gln Arg Met Val Asp Phe Ala Gly Val Lys Asp 
145                 150                 155                 160 


Lys Val Thr Leu Val Val Gly Ala Ser Gln Asp Ile Ile Pro Gln Leu 
                165                 170                 175     


Lys Lys Lys Tyr Asp Val Asp Thr Leu Asp Met Val Phe Leu Asp His 
            180                 185                 190         


Trp Lys Asp Arg Tyr Leu Pro Asp Thr Leu Leu Leu Glu Glu Cys Gly 
        195                 200                 205             


Leu Leu Arg Lys Gly Thr Val Leu Leu Ala Asp Asn Val Ile Cys Pro 
    210                 215                 220                 


Gly Ala Pro Asp Phe Leu Ala His Val Arg Gly Ser Ser Cys Phe Glu 
225                 230                 235                 240 


Cys Thr His Tyr Gln Ser Phe Leu Glu Tyr Arg Glu Val Val Asp Gly 
                245                 250                 255     


Leu Glu Lys Ala Ile Tyr Lys Gly Pro Gly Ser Glu Ala Gly Pro 
            260                 265                 270     


<210>  29
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg 
1               5                   10                  15      


Ser Pro Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly 
        35                  40                  45              


Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
    50                  55                  60                  


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
65                  70                  75                  80  


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
                85                  90                  95      


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
            100                 105                 110         


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
        115                 120                 125             


Val Ala His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln 
    130                 135                 140                 


Ala Ser Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu 
145                 150                 155                 160 


Leu Ser Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser 
                165                 170                 175     


Leu Ser Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His 
            180                 185                 190         


Thr Ala Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln 
        195                 200                 205             


Lys Gln Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr 
    210                 215                 220                 


Val Pro Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala 
225                 230                 235                 240 


Leu Ser Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser 
                245                 250                 255     


Ser Pro Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn 
            260                 265                 270         


Thr 
    


<210>  30
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  30

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  31
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  32
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  33
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  34
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  35
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Met Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys His Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  36
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  36

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Leu Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  37
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  37

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asn Leu Asp Ser Val Ser Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Lys Gly Ser 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Pro 
225                 230                 235                 240 


Gly Thr Lys Val Asp Ile Lys 
                245         


<210>  38
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  38

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  39
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  40
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  40

Gln Val Thr Leu Lys Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ala Asp Lys Ser Met Asp Thr Ser Phe 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ser Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  41
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Met Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-L1

<400>  42

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-L2

<400>  43

Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10          


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-L3

<400>  44

Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-H1

<400>  45

Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His Ile His 
1               5                   10          


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-H2

<400>  46

Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly Lys 
        


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-H3

<400>  47

Glu Glu Ile Thr Tyr Ala Met Asp Tyr 
1               5                   


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-L1

<400>  48

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-L2

<400>  49

Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10          


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-L3

<400>  50

Met Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-H1

<400>  51

Ser Gly Tyr Thr Phe Thr Ser Tyr His Met His 
1               5                   10      


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-H2

<400>  52

Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA antigen binding domain CDR-H3

<400>  53

Glu Gly Thr Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  54
<211>  670
<212>  PRT
<213>  Unknown

<220>  
<223>  LILRB1

<400>  54

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Leu Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Ile Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
545                 550                 555                 560 


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
                565                 570                 575     


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
            580                 585                 590         


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
        595                 600                 605             


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
    610                 615                 620                 


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
625                 630                 635                 640 


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His Pro Ser Gln Glu Gly Pro 
                645                 650                 655     


Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
            660                 665                 670 


<210>  55
<211>  3229
<212>  DNA
<213>  Unknown

<220>  
<223>  LILRB1

<400>  55
aaatgagttt taaaaaggct tgtccaggaa gcacatatgg gagctggtca ctctgcattt       60

tgggccctcc tggaggtgtt tagaccttcc gagagagaaa ctgagacaca tgagagggaa      120

gaaatgactc agtggtgaga ccctgtggag tcccacccac aaccagcaca ctgtgaccca      180

ctgcacaaac ctctagccca cagctcactt cctcctttaa gaagagaaga gaaaagagga      240

gaggagagga ggaacagaaa agaaaagaaa agaaaaagtg ggaaacaaat aatctaagaa      300

tgaggagaaa gcaagaagag tgaccccctt gtgggcactc cattggtttt atggcgcctc      360

tactttctgg agtttgtgta aaacaaaaat attatggtct ttgtgcacat ttacatcaag      420

ctcagcctgg gcggcacagc cagatgcgag atgcgtctct gctgatctga gtctgcctgc      480

agcatggacc tgggtcttcc ctgaagcatc tccagggctg gagggacgac tgccatgcac      540

cgagggctca tccatccaca gagcagggca gtgggaggag acgccatgac ccccatcctc      600

acggtcctga tctgtctcgg gctgagtctg ggcccccgga cccacgtgca ggcagggcac      660

ctccccaagc ccaccctctg ggctgaacca ggctctgtga tcacccaggg gagtcctgtg      720

accctcaggt gtcagggggg ccaggagacc caggagtacc gtctatatag agaaaagaaa      780

acagcaccct ggattacacg gatcccacag gagcttgtga agaagggcca gttccccatc      840

ccatccatca cctgggaaca cacagggcgg tatcgctgtt actatggtag cgacactgca      900

ggccgctcag agagcagtga ccccctggag ctggtggtga caggagccta catcaaaccc      960

accctctcag cccagcccag ccccgtggtg aactcaggag ggaatgtaac cctccagtgt     1020

gactcacagg tggcatttga tggcttcatt ctgtgtaagg aaggagaaga tgaacaccca     1080

caatgcctga actcccagcc ccatgcccgt gggtcgtccc gcgccatctt ctccgtgggc     1140

cccgtgagcc cgagtcgcag gtggtggtac aggtgctatg cttatgactc gaactctccc     1200

tatgagtggt ctctacccag tgatctcctg gagctcctgg tcctaggtgt ttctaagaag     1260

ccatcactct cagtgcagcc aggtcctatc gtggcccctg aggagaccct gactctgcag     1320

tgtggctctg atgctggcta caacagattt gttctgtata aggacgggga acgtgacttc     1380

cttcagctcg ctggcgcaca gccccaggct gggctctccc aggccaactt caccctgggc     1440

cctgtgagcc gctcctacgg gggccagtac agatgctacg gtgcacacaa cctctcctcc     1500

gagtggtcgg cccccagcga ccccctggac atcctgatcg caggacagtt ctatgacaga     1560

gtctccctct cggtgcagcc gggccccacg gtggcctcag gagagaacgt gaccctgctg     1620

tgtcagtcac agggatggat gcaaactttc cttctgacca aggagggggc agctgatgac     1680

ccatggcgtc taagatcaac gtaccaatct caaaaatacc aggctgaatt ccccatgggt     1740

cctgtgacct cagcccatgc ggggacctac aggtgctacg gctcacagag ctccaaaccc     1800

tacctgctga ctcaccccag tgaccccctg gagctcgtgg tctcaggacc gtctgggggc     1860

cccagctccc cgacaacagg ccccacctcc acatctggcc ctgaggacca gcccctcacc     1920

cccaccgggt cggatcccca gagtggtctg ggaaggcacc tgggggttgt gatcggcatc     1980

ttggtggccg tcatcctact gctcctcctc ctcctcctcc tcttcctcat cctccgacat     2040

cgacgtcagg gcaaacactg gacatcgacc cagagaaagg ctgatttcca acatcctgca     2100

ggggctgtgg ggccagagcc cacagacaga ggcctgcagt ggaggtccag cccagctgcc     2160

gatgcccagg aagaaaacct ctatgctgcc gtgaagcaca cacagcctga ggatggggtg     2220

gagatggaca ctcggagccc acacgatgaa gacccccagg cagtgacgta tgccgaggtg     2280

aaacactcca gacctaggag agaaatggcc tctcctcctt ccccactgtc tggggaattc     2340

ctggacacaa aggacagaca ggcggaagag gacaggcaga tggacactga ggctgctgca     2400

tctgaagccc cccaggatgt gacctacgcc cagctgcaca gcttgaccct cagacgggag     2460

gcaactgagc ctcctccatc ccaggaaggg ccctctccag ctgtgcccag catctacgcc     2520

actctggcca tccactagcc caggggggga cgcagacccc acactccatg gagtctggaa     2580

tgcatgggag ctgccccccc agtggacacc attggacccc acccagcctg gatctacccc     2640

aggagactct gggaactttt aggggtcact caattctgca gtataaataa ctaatgtctc     2700

tacaattttg aaataaagca acagacttct caataatcaa tgaagtagct gagaaaacta     2760

agtcagaaag tgcattaaac tgaatcacaa tgtaaatatt acacatcaag cgatgaaact     2820

ggaaaactac aagccacgaa tgaatgaatt aggaaagaaa aaaagtagga aatgaatgat     2880

cttggctttc ctataagaaa tttagggcag ggcacggtgg ctcacgcctg taattccagc     2940

actttgggag gccgaggcgg gcagatcacg agttcaggag atcgagacca tcttggccaa     3000

catggtgaaa ccctgtctct cctaaaaata caaaaattag ctggatgtgg tggcagtgcc     3060

tgtaatccca gctatttggg aggctgaggc aggagaatcg cttgaaccag ggagtcagag     3120

gtttcagtga gccaagatcg caccactgct ctccagcctg gcgacagagg gagactccat     3180

ctcaaattaa aaaaaaaaaa aaaaaagaaa gaaaaaaaaa aaaaaaaaa                 3229


<210>  56
<211>  6
<212>  PRT
<213>  Unknown

<220>  
<223>  immunoreceptor tyrosine-based inhibitory motif

<400>  56

Asn Leu Tyr Ala Ala Val 
1               5       


<210>  57
<211>  6
<212>  PRT
<213>  Unknown

<220>  
<223>  immunoreceptor tyrosine-based inhibitory motif

<400>  57

Val Thr Tyr Ala Glu Val 
1               5       


<210>  58
<211>  6
<212>  PRT
<213>  Unknown

<220>  
<223>  immunoreceptor tyrosine-based inhibitory motif

<400>  58

Val Thr Tyr Ala Gln Leu 
1               5       


<210>  59
<211>  6
<212>  PRT
<213>  Unknown

<220>  
<223>  immunoreceptor tyrosine-based inhibitory motif

<400>  59

Ser Ile Tyr Ala Thr Leu 
1               5       


<210>  60
<211>  35
<212>  PRT
<213>  Unknown

<220>  
<223>  ITIM1-2

<400>  60

Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
1               5                   10                  15      


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            20                  25                  30          


Ala Glu Val 
        35  


<210>  61
<211>  58
<212>  PRT
<213>  Unknown

<220>  
<223>  ITIM2-3

<400>  61

Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
1               5                   10                  15      


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            20                  25                  30          


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        35                  40                  45              


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu 
    50                  55              


<210>  62
<211>  36
<212>  PRT
<213>  Unknown

<220>  
<223>  ITIM3-4

<400>  62

Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr 
1               5                   10                  15      


Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile 
            20                  25                  30          


Tyr Ala Thr Leu 
        35      


<210>  63
<211>  87
<212>  PRT
<213>  Unknown

<220>  
<223>  ITIM1-3

<400>  63

Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
1               5                   10                  15      


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            20                  25                  30          


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
        35                  40                  45              


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
    50                  55                  60                  


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
65                  70                  75                  80  


Asp Val Thr Tyr Ala Gln Leu 
                85          


<210>  64
<211>  88
<212>  PRT
<213>  Unknown

<220>  
<223>  ITIM2-4

<400>  64

Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
1               5                   10                  15      


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            20                  25                  30          


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        35                  40                  45              


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg 
    50                  55                  60                  


Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala 
65                  70                  75                  80  


Val Pro Ser Ile Tyr Ala Thr Leu 
                85              


<210>  65
<211>  117
<212>  PRT
<213>  Unknown

<220>  
<223>  ITIM1-4

<400>  65

Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
1               5                   10                  15      


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            20                  25                  30          


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
        35                  40                  45              


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
    50                  55                  60                  


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
65                  70                  75                  80  


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
                85                  90                  95      


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
            100                 105                 110         


Ile Tyr Ala Thr Leu 
        115         


<210>  66
<211>  20
<212>  PRT
<213>  Unknown

<220>  
<223>  D3D4 domain

<400>  66

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu 
            20  


<210>  67
<211>  43
<212>  PRT
<213>  Unknown

<220>  
<223>  Short hinge

<400>  67

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
        35                  40              


<210>  68
<211>  86
<212>  PRT
<213>  Unknown

<220>  
<223>  Hinge-transmembrane

<400>  68

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Phe Leu Ile Leu 
                85      


<210>  69
<211>  190
<212>  PRT
<213>  Unknown

<220>  
<223>  Transmembrane-intracellular domain.

<400>  69

Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp 
            20                  25                  30          


Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val 
        35                  40                  45              


Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala 
    50                  55                  60                  


Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln 
65                  70                  75                  80  


Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp 
                85                  90                  95      


Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg 
            100                 105                 110         


Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr 
        115                 120                 125             


Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala 
    130                 135                 140                 


Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu 
145                 150                 155                 160 


Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro 
                165                 170                 175     


Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
            180                 185                 190 


<210>  70
<211>  167
<212>  PRT
<213>  Unknown

<220>  
<223>  LILRB1 intracellular domain

<400>  70

Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala 
1               5                   10                  15      


Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg 
            20                  25                  30          


Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn 
        35                  40                  45              


Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met 
    50                  55                  60                  


Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala 
65                  70                  75                  80  


Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser 
                85                  90                  95      


Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu 
            100                 105                 110         


Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp 
        115                 120                 125             


Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr 
    130                 135                 140                 


Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile 
145                 150                 155                 160 


Tyr Ala Thr Leu Ala Ile His 
                165         


<210>  71
<211>  253
<212>  PRT
<213>  Unknown

<220>  
<223>  LILRB1 hinge-transmembrane-intracellular domain

<400>  71

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr 
                85                  90                  95      


Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly 
            100                 105                 110         


Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala 
        115                 120                 125             


Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro 
    130                 135                 140                 


Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro 
145                 150                 155                 160 


Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu 
                165                 170                 175     


Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys 
            180                 185                 190         


Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala 
        195                 200                 205             


Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr 
    210                 215                 220                 


Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser 
225                 230                 235                 240 


Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                245                 250             


<210>  72
<211>  233
<212>  PRT
<213>  Unknown

<220>  
<223>  LILRB1  hinge-transmembrane-intracellular domain

<400>  72

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile 
        35                  40                  45              


Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu 
    50                  55                  60                  


Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg 
65                  70                  75                  80  


Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr 
                85                  90                  95      


Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu 
            100                 105                 110         


Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val 
        115                 120                 125             


Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr 
    130                 135                 140                 


Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro 
145                 150                 155                 160 


Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala 
                165                 170                 175     


Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro 
            180                 185                 190         


Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu 
        195                 200                 205             


Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro 
    210                 215                 220                 


Ser Ile Tyr Ala Thr Leu Ala Ile His 
225                 230             


<210>  73
<211>  63
<212>  PRT
<213>  Unknown

<220>  
<223>  LILRB1 hinge domain

<400>  73

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    50                  55                  60              


<210>  74
<211>  23
<212>  PRT
<213>  Unknown

<220>  
<223>  LILRB1 transmembrane domain

<400>  74

Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ile Leu 
            20              


<210>  75
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Arg Gln Thr Leu Pro Leu Leu Leu Leu Thr Val Leu Arg Pro Ser 
1               5                   10                  15      


Trp Ala Asp Pro Pro Gln Glu Lys Val Pro Leu Phe Arg Val Thr Gln 
            20                  25                  30          


Gln Gly Pro Trp Gly Ser Ser Gly Ser Asn Ala Thr Asp Ser Pro Cys 
        35                  40                  45              


Glu Gly Leu Pro Ala Ala Asp Ala Thr Ala Leu Thr Leu Ala Asn Arg 
    50                  55                  60                  


Asn Leu Glu Arg Leu Pro Gly Cys Leu Pro Arg Thr Leu Arg Ser Leu 
65                  70                  75                  80  


Asp Ala Ser His Asn Leu Leu Arg Ala Leu Ser Thr Ser Glu Leu Gly 
                85                  90                  95      


His Leu Glu Gln Leu Gln Val Leu Thr Leu Arg His Asn Arg Ile Ala 
            100                 105                 110         


Ala Leu Arg Trp Gly Pro Gly Gly Pro Ala Gly Leu His Thr Leu Asp 
        115                 120                 125             


Leu Ser Tyr Asn Gln Leu Ala Ala Leu Pro Pro Cys Thr Gly Pro Ala 
    130                 135                 140                 


Leu Ser Ser Leu Arg Ala Leu Ala Leu Ala Gly Asn Pro Leu Arg Ala 
145                 150                 155                 160 


Leu Gln Pro Arg Ala Phe Ala Cys Phe Pro Ala Leu Gln Leu Leu Asn 
                165                 170                 175     


Leu Ser Cys Thr Ala Leu Gly Arg Gly Ala Gln Gly Gly Ile Ala Glu 
            180                 185                 190         


Ala Ala Phe Ala Gly Glu Asp Gly Ala Pro Leu Val Thr Leu Glu Val 
        195                 200                 205             


Leu Asp Leu Ser Gly Thr Phe Leu Glu Arg Val Glu Ser Gly Trp Ile 
    210                 215                 220                 


Arg Asp Leu Pro Lys Leu Thr Ser Leu Tyr Leu Arg Lys Met Pro Arg 
225                 230                 235                 240 


Leu Thr Thr Leu Glu Gly Asp Ile Phe Lys Met Thr Pro Asn Leu Gln 
                245                 250                 255     


Gln Leu Asp Cys Gln Asp Ser Pro Ala Leu Ala Ser Val Ala Thr His 
            260                 265                 270         


Ile Phe Gln Asp Thr Pro His Leu Gln Val Leu Leu Phe Gln Asn Cys 
        275                 280                 285             


Asn Leu Ser Ser Phe Pro Pro Trp Thr Leu Asp Ser Ser Gln Val Leu 
    290                 295                 300                 


Ser Ile Asn Leu Phe Gly Asn Pro Leu Thr Cys Ser Cys Asp Leu Ser 
305                 310                 315                 320 


Trp Leu Leu Thr Asp Ala Lys Arg Thr Val Leu Ser Arg Ala Ala Asp 
                325                 330                 335     


Thr Met Cys Ala Pro Ala Ala Gly Ser Ser Gly Pro Phe Ser Ala Ser 
            340                 345                 350         


Leu Ser Leu Ser Gln Leu Pro Gly Val Cys Gln Ser Asp Gln Ser Thr 
        355                 360                 365             


Thr Leu Gly Ala Ser His Pro Pro Cys Phe Asn Arg Ser Thr Tyr Ala 
    370                 375                 380                 


Gln Gly Thr Thr Val Ala Pro Ser Ala Ala Pro Ala Thr Arg Pro Ala 
385                 390                 395                 400 


Gly Asp Gln Gln Ser Val Ser Lys Ala Pro Asn Val Gly Ser Arg Thr 
                405                 410                 415     


Ile Ala Ala Trp Pro His Ser Asp Ala Arg Glu Gly Thr Ala Pro Ser 
            420                 425                 430         


Thr Thr Asn Ser Val Ala Gly His Ser Asn Ser Ser Val Phe Pro Arg 
        435                 440                 445             


Ala Ala Ser Thr Thr Arg Thr Gln His Arg Gly Glu His Ala Pro Glu 
    450                 455                 460                 


Leu Val Leu Glu Pro Asp Ile Ser Ala Ala Ser Thr Pro Leu Ala Ser 
465                 470                 475                 480 


Lys Leu Leu Gly Pro Phe Pro Thr Ser Trp Asp Arg Ser Ile Ser Ser 
                485                 490                 495     


Pro Gln Pro Gly Gln Arg Thr His Ala Thr Pro Gln Ala Pro Asn Pro 
            500                 505                 510         


Ser Leu Ser Glu Gly Glu Ile Pro Val Leu Leu Leu Asp Asp Tyr Ser 
        515                 520                 525             


Glu Glu Glu Glu Gly Arg Lys Glu Glu Val Gly Thr Pro His Gln Asp 
    530                 535                 540                 


Val Pro Cys Asp Tyr His Pro Cys Lys His Leu Gln Thr Pro Cys Ala 
545                 550                 555                 560 


Glu Leu Gln Arg Arg Trp Arg Cys Arg Cys Pro Gly Leu Ser Gly Glu 
                565                 570                 575     


Asp Thr Ile Pro Asp Pro Pro Arg Leu Gln Gly Val Thr Glu Thr Thr 
            580                 585                 590         


Asp Thr Ser Ala Leu Val His Trp Cys Ala Pro Asn Ser Val Val His 
        595                 600                 605             


Gly Tyr Gln Ile Arg Tyr Ser Ala Glu Gly Trp Ala Gly Asn Gln Ser 
    610                 615                 620                 


Val Val Gly Val Ile Tyr Ala Thr Ala Arg Gln His Pro Leu Tyr Gly 
625                 630                 635                 640 


Leu Ser Pro Gly Thr Thr Tyr Arg Val Cys Val Leu Ala Ala Asn Arg 
                645                 650                 655     


Ala Gly Leu Ser Gln Pro Arg Ser Ser Gly Trp Arg Ser Pro Cys Ala 
            660                 665                 670         


Ala Phe Thr Thr Lys Pro Ser Phe Ala Leu Leu Leu Ser Gly Leu Cys 
        675                 680                 685             


Ala Ala Ser Gly Leu Leu Leu Ala Ser Thr Val Val Leu Ser Ala Cys 
    690                 695                 700                 


Leu Cys Arg Arg Gly Gln Thr Leu Gly Leu Gln Arg Cys Asp Thr His 
705                 710                 715                 720 


Leu Val Ala Tyr Lys Asn Pro Ala Phe Asp Asp Tyr Pro Leu Gly Leu 
                725                 730                 735     


Gln Thr Val Ser 
            740 


<210>  76
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Gly Leu Pro Trp Gly Gln Pro His Leu Gly Leu Gln Met Leu Leu 
1               5                   10                  15      


Leu Ala Leu Asn Cys Leu Arg Pro Ser Leu Ser Leu Gly Glu Trp Gly 
            20                  25                  30          


Ser Trp Met Asp Ala Ser Ser Gln Thr Gln Gly Ala Gly Gly Pro Ala 
        35                  40                  45              


Gly Val Ile Gly Pro Trp Ala Pro Ala Pro Leu Arg Leu Gly Glu Ala 
    50                  55                  60                  


Ala Pro Gly Thr Pro Thr Pro Val Ser Val Ala His Leu Leu Ser Pro 
65                  70                  75                  80  


Val Ala Thr Glu Leu Val Pro Tyr Thr Pro Gln Ile Thr Ala Trp Asp 
                85                  90                  95      


Leu Glu Gly Lys Val Thr Ala Thr Thr Phe Ser Leu Glu Gln Pro Arg 
            100                 105                 110         


Cys Val Phe Asp Gly Leu Ala Ser Ala Ser Asp Thr Val Trp Leu Val 
        115                 120                 125             


Val Ala Phe Ser Asn Ala Ser Arg Gly Phe Gln Asn Pro Glu Thr Leu 
    130                 135                 140                 


Ala Asp Ile Pro Ala Ser Pro Gln Leu Leu Thr Asp Gly His Tyr Met 
145                 150                 155                 160 


Thr Leu Pro Leu Ser Pro Asp Gln Leu Pro Cys Gly Asp Pro Met Ala 
                165                 170                 175     


Gly Ser Gly Gly Ala Pro Val Leu Arg Val Gly His Asp His Gly Cys 
            180                 185                 190         


His Gln Gln Pro Phe Cys Asn Ala Pro Leu Pro Gly Pro Gly Pro Tyr 
        195                 200                 205             


Arg Glu Asp Pro Arg Ile His Arg His Leu Ala Arg Ala Ala Lys Trp 
    210                 215                 220                 


Gln His Asp Arg His Tyr Leu His Pro Leu Phe Ser Gly Arg Pro Pro 
225                 230                 235                 240 


Thr Leu Gly Leu Leu Gly Ser Leu Tyr His Ala Leu Leu Gln Pro Val 
                245                 250                 255     


Val Ala Gly Gly Gly Pro Gly Ala Ala Ala Asp Arg Leu Leu His Gly 
            260                 265                 270         


Gln Ala Leu His Asp Pro Pro His Pro Thr Gln Arg Gly Arg His Thr 
        275                 280                 285             


Ala Gly Gly Leu Gln Ala Trp Pro Gly Pro Pro Pro Gln Pro Gln Pro 
    290                 295                 300                 


Leu Ala Trp Pro Leu Cys Met Gly Leu Gly Glu Met Gly Arg Arg Glu 
305                 310                 315                 320 


<210>  77
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Gly Leu Pro Trp Gly Gln Pro His Leu Gly Leu Gln Met Leu Leu 
1               5                   10                  15      


Leu Ala Leu Asn Cys Leu Arg Pro Ser Leu Ser Leu Glu Leu Val Pro 
            20                  25                  30          


Tyr Thr Pro Gln Ile Thr Ala Trp Asp Leu Glu Gly Lys Val Thr Ala 
        35                  40                  45              


Thr Thr Phe Ser Leu Glu Gln Pro Arg Cys Val Phe Asp Gly Leu Ala 
    50                  55                  60                  


Ser Ala Ser Asp Thr Val Trp Leu Val Val Ala Phe Ser Asn Ala Ser 
65                  70                  75                  80  


Arg Gly Phe Gln Asn Pro Glu Thr Leu Ala Asp Ile Pro Ala Ser Pro 
                85                  90                  95      


Gln Leu Leu Thr Asp Gly His Tyr Met Thr Leu Pro Leu Ser Pro Asp 
            100                 105                 110         


Gln Leu Pro Cys Gly Asp Pro Met Ala Gly Ser Gly Gly Ala Pro Val 
        115                 120                 125             


Leu Arg Val Gly His Asp His Gly Cys His Gln Gln Pro Phe Cys Asn 
    130                 135                 140                 


Ala Pro Leu Pro Gly Pro Gly Pro Tyr Arg Val Lys Phe Leu Leu Met 
145                 150                 155                 160 


Asp Thr Arg Gly Ser Pro Arg Ala Glu Thr Lys Trp Ser Asp Pro Ile 
                165                 170                 175     


Thr Leu His Gln Gly Lys Thr Pro Gly Ser Ile Asp Thr Trp Pro Gly 
            180                 185                 190         


Arg Arg Ser Gly Ser Met Ile Val Ile Thr Ser Ile Leu Ser Ser Leu 
        195                 200                 205             


Ala Gly Leu Leu Leu Leu Ala Phe Leu Ala Ala Ser Thr Met Arg Phe 
    210                 215                 220                 


Ser Ser Leu Trp Trp Pro Glu Glu Ala Pro Glu Gln Leu Arg Ile Gly 
225                 230                 235                 240 


Ser Phe Met Gly Lys Arg Tyr Met Thr His His Ile Pro Pro Ser Glu 
                245                 250                 255     


Ala Ala Thr Leu Pro Val Gly Cys Lys Pro Gly Leu Asp Pro Leu Pro 
            260                 265                 270         


Ser Leu Ser Pro 
        275     


<210>  78
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Gly Leu Pro Trp Gly Gln Pro His Leu Gly Leu Gln Met Leu Leu 
1               5                   10                  15      


Leu Ala Leu Asn Cys Leu Arg Pro Ser Leu Ser Leu Glu Leu Val Pro 
            20                  25                  30          


Tyr Thr Pro Gln Ile Thr Ala Trp Asp Leu Glu Gly Lys Val Thr Ala 
        35                  40                  45              


Thr Thr Phe Ser Leu Glu Gln Pro Arg Cys Val Phe Asp Gly Leu Ala 
    50                  55                  60                  


Ser Ala Ser Asp Thr Val Trp Leu Val Val Ala Phe Ser Asn Ala Ser 
65                  70                  75                  80  


Arg Gly Phe Gln Asn Pro Glu Thr Leu Ala Asp Ile Pro Ala Ser Pro 
                85                  90                  95      


Gln Leu Leu Thr Asp Gly His Tyr Met Thr Leu Pro Leu Ser Pro Asp 
            100                 105                 110         


Gln Leu Pro Cys Gly Asp Pro Met Ala Gly Ser Gly Gly Ala Pro Val 
        115                 120                 125             


Leu Arg Val Gly His Asp His Gly Cys His Gln Gln Pro Phe Cys Asn 
    130                 135                 140                 


Ala Pro Leu Pro Gly Pro Gly Pro Tyr Arg Glu Asp Pro Arg Ile His 
145                 150                 155                 160 


Arg His Leu Ala Arg Ala Ala Lys Trp Gln His Asp Arg His Tyr Leu 
                165                 170                 175     


His Pro Leu Phe Ser Gly Arg Pro Pro Thr Leu Gly Leu Leu Gly Ser 
            180                 185                 190         


Leu Tyr His Ala Leu Leu Gln Pro Val Val Ala Gly Gly Gly Pro Gly 
        195                 200                 205             


Ala Ala Ala Asp Arg Leu Leu His Gly Gln Ala Leu His Asp Pro Pro 
    210                 215                 220                 


His Pro Thr Gln Arg Gly Arg His Thr Ala Gly Gly Leu Gln Ala Trp 
225                 230                 235                 240 


Pro Gly Pro Pro Pro Gln Pro Gln Pro Leu Ala Trp Pro Leu Cys Met 
                245                 250                 255     


Gly Leu Gly Glu Met Gly Arg Arg Glu 
            260                 265 


<210>  79
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Gly Leu Pro Trp Gly Gln Pro His Leu Gly Leu Gln Met Leu Leu 
1               5                   10                  15      


Leu Ala Leu Asn Cys Leu Arg Pro Ser Leu Ser Leu Glu Leu Val Pro 
            20                  25                  30          


Tyr Thr Pro Gln Ile Thr Ala Trp Asp Leu Glu Gly Lys Val Thr Ala 
        35                  40                  45              


Thr Thr Phe Ser Leu Glu Gln Pro Arg Cys Val Phe Asp Gly Leu Ala 
    50                  55                  60                  


Ser Ala Ser Asp Thr Val Trp Leu Val Val Ala Phe Ser Asn Ala Ser 
65                  70                  75                  80  


Arg Gly Phe Gln Asn Pro Glu Thr Leu Ala Asp Ile Pro Ala Ser Pro 
                85                  90                  95      


Gln Leu Leu Thr Asp Gly His Tyr Met Thr Leu Pro Leu Ser Pro Asp 
            100                 105                 110         


Gln Leu Pro Cys Gly Asp Pro Met Ala Gly Ser Gly Gly Ala Pro Val 
        115                 120                 125             


Leu Arg Val Gly His Asp His Gly Cys His Gln Gln Pro Phe Cys Asn 
    130                 135                 140                 


Ala Pro Leu Pro Gly Pro Gly Pro Tyr Arg Val Lys Phe Leu Leu Met 
145                 150                 155                 160 


Asp Thr Arg Gly Ser Pro Arg Ala Glu Thr Lys Trp Ser Asp Pro Ile 
                165                 170                 175     


Thr Leu His Gln Gly Lys Thr Pro Gly Ser Ile Asp Thr Trp Pro Gly 
            180                 185                 190         


Arg Arg Ser Gly Ser Met Ile Val Ile Thr Ser Ile Leu Ser Ser Leu 
        195                 200                 205             


Ala Gly Leu Leu Leu Leu Ala Phe Leu Ala Ala Ser Thr Met Arg Phe 
    210                 215                 220                 


Ser Ser Leu Trp Trp Pro Glu Glu Ala Pro Glu Gln Leu Arg Ile Gly 
225                 230                 235                 240 


Ser Phe Met Gly Lys Arg Tyr Met Thr His His Ile Pro Pro Arg Glu 
                245                 250                 255     


Ala Ala Thr Leu Pro Val Gly Cys Lys Pro Gly Leu Asp Pro Leu Pro 
            260                 265                 270         


Ser Leu Ser Pro 
        275     


<210>  80
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  80

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 


<210>  81
<211>  64
<212>  PRT
<213>  Unknown

<220>  
<223>  Hinge (iTIM hinge)

<400>  81

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


<210>  82
<211>  44
<212>  PRT
<213>  Unknown

<220>  
<223>  Short hinge 2

<400>  82

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
        35                  40                  


<210>  83
<211>  67
<212>  PRT
<213>  Unknown

<220>  
<223>  Long hinge 1

<400>  83

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val Pro Ser 
        35                  40                  45              


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
    50                  55                  60                  


Ala Ser Val 
65          


<210>  84
<211>  75
<212>  PRT
<213>  Unknown

<220>  
<223>  Long hinge 2

<400>  84

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr 
        35                  40                  45              


Pro Ser Pro Ser Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser 
    50                  55                  60                  


Thr Pro Pro Thr Pro Ser Pro Ser Ala Ser Val 
65                  70                  75  


<210>  85
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PA2.1.14 (VL:VH) scFv LIR1 sHTICD

<400>  85

Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
1               5                   10                  15      


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
            20                  25                  30          


Gly Thr Lys Val Glu Val Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Gly Gly Gln Val Gln Leu Val Gln Ser Gly 
    50                  55                  60                  


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
65                  70                  75                  80  


Ser Gly Tyr Thr Phe Thr Ser Tyr His Ile His Trp Val Arg Gln Ala 
                85                  90                  95      


Pro Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val 
            100                 105                 110         


Asn Thr Glu Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Ile Thr Ala 
        115                 120                 125             


Asp Glu Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
    130                 135                 140                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Glu Ile Thr Tyr Ala 
145                 150                 155                 160 


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Val 
                165                 170                 175     


Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser 
            180                 185                 190         


Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro 
        195                 200                 205             


Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile Leu Val 
    210                 215                 220                 


Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu 
225                 230                 235                 240 


Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala 
                245                 250                 255     


Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg 
            260                 265                 270         


Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn 
        275                 280                 285             


Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met 
    290                 295                 300                 


Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala 
305                 310                 315                 320 


Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser 
                325                 330                 335     


Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu 
            340                 345                 350         


Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp 
        355                 360                 365             


Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr 
    370                 375                 380                 


Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile 
385                 390                 395                 400 


Tyr Ala Thr Leu Ala Ile His 
                405         


<210>  86
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PA2.1.14 (VL:VH) scFv LIR1 HTICD

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala 
        195                 200                 205             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr 
                245                 250                 255     


Leu Leu Thr His Pro Ser Asp Pro Leu Glu Leu Val Val Ser Gly Pro 
            260                 265                 270         


Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly 
        275                 280                 285             


Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly 
    290                 295                 300                 


Leu Gly Arg His Leu Gly Val Val Ile Gly Ile Leu Val Ala Val Ile 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg 
                325                 330                 335     


Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln 
            340                 345                 350         


His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln 
        355                 360                 365             


Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala 
    370                 375                 380                 


Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg 
385                 390                 395                 400 


Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys 
                405                 410                 415     


His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser 
            420                 425                 430         


Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln 
        435                 440                 445             


Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr 
    450                 455                 460                 


Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro 
465                 470                 475                 480 


Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr 
                485                 490                 495     


Leu Ala Ile His 
            500 


<210>  87
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN_SsI CD8_HT 41BB CD3z

<400>  87

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                245                 250                 255     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            260                 265                 270         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
        275                 280                 285             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    290                 295                 300                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
305                 310                 315                 320 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                325                 330                 335     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  88
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PA2.1.14 scFv LIR1 sHTICD

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys Val Val Ser Gly Pro Ser Gly Gly Pro 
                245                 250                 255     


Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln 
            260                 265                 270         


Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His 
        275                 280                 285             


Leu Gly Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu 
    290                 295                 300                 


Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys 
305                 310                 315                 320 


His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly 
                325                 330                 335     


Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser 
            340                 345                 350         


Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His 
        355                 360                 365             


Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp 
    370                 375                 380                 


Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro 
385                 390                 395                 400 


Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu 
                405                 410                 415     


Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu 
            420                 425                 430         


Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His 
        435                 440                 445             


Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu 
    450                 455                 460                 


Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
465                 470                 475                 480 


<210>  89
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PA2.1.14 scFv LIR1 HTICD

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys Tyr Gly Ser Gln Ser Ser Lys Pro Tyr 
                245                 250                 255     


Leu Leu Thr His Pro Ser Asp Pro Leu Glu Leu Val Val Ser Gly Pro 
            260                 265                 270         


Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly 
        275                 280                 285             


Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly 
    290                 295                 300                 


Leu Gly Arg His Leu Gly Val Val Ile Gly Ile Leu Val Ala Val Ile 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg 
                325                 330                 335     


Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln 
            340                 345                 350         


His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln 
        355                 360                 365             


Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala 
    370                 375                 380                 


Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg 
385                 390                 395                 400 


Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys 
                405                 410                 415     


His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser 
            420                 425                 430         


Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln 
        435                 440                 445             


Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr 
    450                 455                 460                 


Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro 
465                 470                 475                 480 


Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr 
                485                 490                 495     


Leu Ala Ile His 
            500 


<210>  90
<211>  32
<212>  PRT
<213>  Unknown

<220>  
<223>  Hinge (truncated)

<400>  90

Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
1               5                   10                  15      


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
            20                  25                  30          


<210>  91
<211>  85
<212>  PRT
<213>  Unknown

<220>  
<223>  2X short hinge

<400>  91

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Val Val Ser Gly Pro Ser Gly 
        35                  40                  45              


Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu 
    50                  55                  60                  


Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly 
65                  70                  75                  80  


Arg His Leu Gly Val 
                85  


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H1

<400>  92

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H1

<400>  93

Thr Ser Gly Val Gly Val Gly 
1               5           


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H1

<400>  94

Ser Tyr Ala Met His 
1               5   


<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H1

<400>  95

Ser Tyr Asp Met His 
1               5   


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H1

<400>  96

Ser Tyr Trp Met His 
1               5   


<210>  97
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H2

<400>  97

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  98
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H2

<400>  98

Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H2

<400>  99

Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H2

<400>  100

Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys Gly 
1               5                   10                  15      


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H2

<400>  101

Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H3

<400>  102

His Tyr Tyr Tyr Tyr Ser Met Asp Val 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H3

<400>  103

His Tyr Tyr Tyr Tyr Tyr Leu Asp Val 
1               5                   


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H3

<400>  104

His Tyr Tyr Tyr Tyr Met Asp Val 
1               5               


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H3

<400>  105

His Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H3

<400>  106

Lys Thr Thr Ser Phe Tyr Phe Asp Tyr 
1               5                   


<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H3

<400>  107

Arg His Met Arg Leu Ser Cys Phe Asp Tyr 
1               5                   10  


<210>  108
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H3

<400>  108

Glu Gly Asn Gly Ala Asn Pro Asp Ala Phe Asp Ile 
1               5                   10          


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H3

<400>  109

Asp Leu Pro Gly Ser Tyr Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR-H3

<400>  110

Gly Val Leu Leu Tyr Asn Trp Phe Asp Pro 
1               5                   10  


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR1 LC

<400>  111

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR2 LC

<400>  112

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 CDR3 LC

<400>  113

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  114
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  114

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  115
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  115

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg His Met Arg Leu Ser Cys Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  116
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  116

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Gly Ala Asn Pro Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  117
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Pro Gly Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  118
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  118

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Tyr Leu Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  119
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  119

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Cys Leu Gly Val Leu Leu Tyr Asn Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  120
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  120

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  121
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  121

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Lys Thr Thr Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  122
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  122

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  123
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  123
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagacac      300

tactactact actccatgga cgtctggggc aaagggacca cggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  124
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  124
cagatcaccc tgaaagagtc cggccccacc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc acctctggcg tgggcgtggg ctggatcaga      120

cagcctcccg gcaaggccct ggaatggctg gccctgatct actggaacga cgacaagcgg      180

tacagcccca gcctgaagtc ccggctgacc atcaccaagg acacctcgaa gaaccaggtg      240

gtgctgacca tgacaaacat ggaccccgtg gacaccgcca catattactg tgcacacaga      300

cacatgcgtt taagctgttt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      480

cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc agggaaagcc      540

cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt      600

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc tgaagatttt      660

gcaacttact actgtcaaca gagttacagt acccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  125
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  125
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacgcca tgcactgggt tcgacaggcc      120

cctggccaga gactggaatg gatgggctgg atcaacgccg gcaacggcaa caccaagtac      180

agccagaaat tccagggcag agtgaccatc acccgggaca ccagcgccag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgctgtgt attactgtgc gagagaagga      300

aatggtgcca accctgatgc ttttgatatc tggggccaag ggacaatggt caccgtgtcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgacatc      420

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      480

tgccgggcaa gtcagagcat tagcagctat ttaaattggt atcagcagaa accagggaaa      540

gcccctaagc tcctgatcta tgctgcatcc agtttgcaaa gtggggtccc atcaaggttc      600

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      660

tttgcaactt actactgtca acagagttac agtacccctc tcactttcgg cggcggaaca      720

aaggtggaga tcaag                                                       735


<210>  126
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  126
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgaca tgcactgggt ccgccaggcc      120

accggcaagg gactggaatg ggtgtccgcc atcggcacag ccggcgacac ttactacccc      180

ggcagcgtga agggccggtt caccatcagc agagagaacg ccaagaacag cctgtacctg      240

cagatgaaca gccttcgagc cggcgatacc gccgtgtatt actgtgcaag agatctccct      300

ggtagctact ggtacttcga tctctggggc cgtggcaccc tggtcactgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  127
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  127
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagacac      300

tactactact actacctgga cgtctggggc aaagggacca cggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  128
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  128
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctactgga tgcactgggt ccgccaggcc      120

cctggcaagg gactggtctg ggtgtctcga atcaacagcg acggcagcag caccagctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgttg tttgggtgtt      300

ttattataca actggttcga cccctggggc cagggaaccc tggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  129
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  129
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagacac      300

tactactact acatggacgt ctggggcaaa gggaccacgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      480

agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagagtta cagtacccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  130
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  130
cagatcaccc tgaaagagtc cggccccacc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc acctctggcg tgggcgtggg ctggatcaga      120

cagcctcccg gcaaggccct ggaatggctg gccctgatct actggaacga cgacaagcgg      180

tacagcccca gcctgaagtc ccggctgacc atcaccaagg acacctcgaa gaaccaggtg      240

gtgctgacca tgacaaacat ggaccccgtg gacaccgcca catattactg tgcacacaaa      300

acgacgtcgt tttactttga ctactggggc cagggaaccc tggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  131
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A*11 antigen binding domain

<400>  131
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagacac      300

tactactact actacatgga cgtctggggc aaagggacca cggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  132
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  132

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  133
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  133

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg His Met Arg Leu Ser Cys Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  134
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  134

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Gly Ala Asn Pro Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  135
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Pro Gly Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  136
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  136

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Tyr Leu Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  137
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Cys Leu Gly Val Leu Leu Tyr Asn Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  138
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  138

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  139
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  139

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Lys Thr Thr Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  140
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  140

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  141
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 light chain

<400>  141

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  142
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  142
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagacac      300

tactactact actccatgga cgtctggggc aaagggacca cggtcaccgt gtcctca         357


<210>  143
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  143
cagatcaccc tgaaagagtc cggccccacc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc acctctggcg tgggcgtggg ctggatcaga      120

cagcctcccg gcaaggccct ggaatggctg gccctgatct actggaacga cgacaagcgg      180

tacagcccca gcctgaagtc ccggctgacc atcaccaagg acacctcgaa gaaccaggtg      240

gtgctgacca tgacaaacat ggaccccgtg gacaccgcca catattactg tgcacacaga      300

cacatgcgtt taagctgttt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360


<210>  144
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  144
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacgcca tgcactgggt tcgacaggcc      120

cctggccaga gactggaatg gatgggctgg atcaacgccg gcaacggcaa caccaagtac      180

agccagaaat tccagggcag agtgaccatc acccgggaca ccagcgccag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgctgtgt attactgtgc gagagaagga      300

aatggtgcca accctgatgc ttttgatatc tggggccaag ggacaatggt caccgtgtcc      360

tca                                                                    363


<210>  145
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  145
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgaca tgcactgggt ccgccaggcc      120

accggcaagg gactggaatg ggtgtccgcc atcggcacag ccggcgacac ttactacccc      180

ggcagcgtga agggccggtt caccatcagc agagagaacg ccaagaacag cctgtacctg      240

cagatgaaca gccttcgagc cggcgatacc gccgtgtatt actgtgcaag agatctccct      300

ggtagctact ggtacttcga tctctggggc cgtggcaccc tggtcactgt gtcctca         357


<210>  146
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  146
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagacac      300

tactactact actacctgga cgtctggggc aaagggacca cggtcaccgt gtcctca         357


<210>  147
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  147
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctactgga tgcactgggt ccgccaggcc      120

cctggcaagg gactggtctg ggtgtctcga atcaacagcg acggcagcag caccagctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgttg tttgggtgtt      300

ttattataca actggttcga cccctggggc cagggaaccc tggtcaccgt gtcctca         357


<210>  148
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  148
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagacac      300

tactactact acatggacgt ctggggcaaa gggaccacgg tcaccgtgtc ctca            354


<210>  149
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  149
cagatcaccc tgaaagagtc cggccccacc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc acctctggcg tgggcgtggg ctggatcaga      120

cagcctcccg gcaaggccct ggaatggctg gccctgatct actggaacga cgacaagcgg      180

tacagcccca gcctgaagtc ccggctgacc atcaccaagg acacctcgaa gaaccaggtg      240

gtgctgacca tgacaaacat ggaccccgtg gacaccgcca catattactg tgcacacaaa      300

acgacgtcgt tttactttga ctactggggc cagggaaccc tggtcaccgt gtcctca         357


<210>  150
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 heavy chain

<400>  150
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagacac      300

tactactact actacatgga cgtctggggc aaagggacca cggtcaccgt gtcctca         357


<210>  151
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-HLA-A*11 light chain

<400>  151
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa g                                                321


<210>  152
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker

<400>  152

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  153
<211>  66
<212>  PRT
<213>  Unknown

<220>  
<223>  encodes signal sequence

<400>  153

Ala Thr Gly Gly Ala Cys Ala Thr Gly Ala Gly Gly Gly Thr Cys Cys 
1               5                   10                  15      


Cys Cys Gly Cys Thr Cys Ala Gly Cys Thr Cys Cys Thr Gly Gly Gly 
            20                  25                  30          


Gly Cys Thr Cys Cys Thr Gly Cys Thr Ala Cys Thr Cys Thr Gly Gly 
        35                  40                  45              


Cys Thr Cys Cys Gly Ala Gly Gly Thr Gly Cys Cys Ala Gly Ala Thr 
    50                  55                  60                  


Gly Thr 
65      


<210>  154
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Leu Pro Lys Leu Arg Asn Phe His Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  155
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Glu Tyr His Gly Phe Arg Gln Tyr Gly Leu Arg Tyr Trp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  156
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  156

Gln Leu Gln Leu Gln Glu Ser Gly Ser Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Ser Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Ile Lys Phe Trp Phe Ala Gly Ile Asn Tyr Phe Phe Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  157
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Phe Leu Gly Met Gly Ser Asn Phe Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  158
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  158

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Leu Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Gly Asp Arg Ala Arg Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  159
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Pro Arg Gly Tyr His Gln Met Val Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  160
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  160

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Arg Phe Leu Ala Ala Arg Thr Thr Ile Pro Glu Ala 
            100                 105                 110         


Asn Phe Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  161
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Arg Ala Arg Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  162
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Gly Arg Val Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  163
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  163

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Lys Phe Thr Ser Phe Leu Tyr Val His Gly Phe Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  164
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  164

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Arg Trp Leu Tyr Leu Gly Gly Ile Arg Arg His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  165
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  165

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Trp Ile Pro Ser Arg Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  166
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  166

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Thr Gly Thr Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  167
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  167

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Arg Tyr Arg Arg Val Leu His Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  168
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  168

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  169
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  169

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu His Met Gly Thr Ile Pro Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  170
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  170

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Glu Phe Gly Tyr Gly Asp Val Leu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  171
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  171

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Asp Val Val Lys Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  172
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Phe Ser His Lys Leu Gly Tyr Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  173
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  173

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Tyr Val Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
145                 150                 155                 160 


Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
    210                 215                 220                 


Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235             


<210>  174
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  174

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Arg Asp Trp Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  175
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  175

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gln Ala Leu Lys Tyr Arg Val Asp Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  176
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  176

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Thr Leu Gly Cys Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  177
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Ser Asn Ser Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  178
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  178

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Phe Leu Phe Leu Ser Phe Ser Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  179
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ile Phe Tyr Ser Ser Lys Glu Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  180
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Trp Ile Phe Tyr Ser Ser Asn Pro Lys Pro Thr Val 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  181
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  181

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Phe Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Asp Gln Thr Leu Thr Tyr Gly Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  182
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  182

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp His Tyr Glu Arg Gly Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  183
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  183

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Met Tyr Asn Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  184
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  184

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Pro Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  185
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  185

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val His Leu Lys Arg Arg Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  186
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  186

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Val His Lys Lys Pro Ile Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  187
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  187

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Arg Arg Cys Thr Phe Gln His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  188
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  188

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Pro Arg Pro Leu Phe Gln His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  189
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  189

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Gln Val Arg Gly Val Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  190
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  190

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Lys Lys Arg Arg Thr Val Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  191
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  191

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Gln Arg Gly Leu Ala Leu Phe Gln His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  192
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  192

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Leu Ser Val Pro Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  193
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  193

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Trp Ile Arg Val Pro Leu Arg Leu Pro Leu Phe Gln His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  194
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  194

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Thr Ile Phe Ala Ile Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  195
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  195

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Arg Gly Phe Val His Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  196
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  196

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Arg Gly Leu Cys Val Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  197
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  197

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Pro Ser Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  198
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  198

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Ile Tyr Met Gly Gly Ile Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  199
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  199

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Val Arg Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  200
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  200

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Thr Ala His Leu Asp Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  201
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  201

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ile Phe Pro Val Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  202
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  202

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Arg Lys Tyr Gly Tyr Val Phe Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  203
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  203

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Arg Tyr Arg Arg Phe Trp His Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  204
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  204

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala His Ile Arg Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  205
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  205

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Met Gly Gly Gly Gly Arg Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  206
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  206

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Arg Thr Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  207
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  207

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Met Gly Gly Gly Gly Arg Leu Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  208
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  208

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Gly Arg Leu Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  209
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  209

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ile Arg Gln Leu Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  210
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  210

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Phe Ala Asn Ser Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  211
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  211

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Asp Arg Thr Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  212
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  212

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Trp Gly Lys Asp Gly Pro Tyr Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  213
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  213

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Arg Asp Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  214
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  214

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Arg Pro Pro Pro Gly Tyr Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  215
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  215

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Arg Phe Ser Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  216
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  216

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Leu Pro Lys Leu Arg Asn Phe His Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  217
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  217

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Glu Tyr His Gly Phe Arg Gln Tyr Gly Leu Arg Tyr Trp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  218
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  218

Gln Leu Gln Leu Gln Glu Ser Gly Ser Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Ser Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Ile Lys Phe Trp Phe Ala Gly Ile Asn Tyr Phe Phe Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  219
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  219

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Phe Leu Gly Met Gly Ser Asn Phe Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  220
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  220

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Leu Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Gly Asp Arg Ala Arg Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  221
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  221

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Pro Arg Gly Tyr His Gln Met Val Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  222
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  222

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Arg Phe Leu Ala Ala Arg Thr Thr Ile Pro Glu Ala 
            100                 105                 110         


Asn Phe Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  223
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  223

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Arg Ala Arg Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  224
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  224

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Gly Arg Val Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  225
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  225

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Lys Phe Thr Ser Phe Leu Tyr Val His Gly Phe Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  226
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  226

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Arg Trp Leu Tyr Leu Gly Gly Ile Arg Arg His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  227
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  227

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Trp Ile Pro Ser Arg Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  228
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  228

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Thr Gly Thr Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  229
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  229

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Arg Tyr Arg Arg Val Leu His Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  230
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  230

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  231
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  231

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu His Met Gly Thr Ile Pro Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  232
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  232

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Glu Phe Gly Tyr Gly Asp Val Leu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  233
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  233

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Asp Val Val Lys Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  234
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  234

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Phe Ser His Lys Leu Gly Tyr Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  235
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  235

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Tyr Val Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  236
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  236

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Arg Asp Trp Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  237
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  237

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gln Ala Leu Lys Tyr Arg Val Asp Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  238
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  238

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Thr Leu Gly Cys Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  239
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  239

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Ser Asn Ser Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  240
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  240

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Phe Leu Phe Leu Ser Phe Ser Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  241
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  241

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ile Phe Tyr Ser Ser Lys Glu Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  242
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  242

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Trp Ile Phe Tyr Ser Ser Asn Pro Lys Pro Thr Val 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  243
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  243

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Phe Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Asp Gln Thr Leu Thr Tyr Gly Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  244
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  244

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp His Tyr Glu Arg Gly Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  245
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  245

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Met Tyr Asn Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  246
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  246

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Pro Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  247
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  247

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val His Leu Lys Arg Arg Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  248
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  248

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Val His Lys Lys Pro Ile Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  249
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  249

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Arg Arg Cys Thr Phe Gln His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  250
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  250

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Pro Arg Pro Leu Phe Gln His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  251
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  251

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Gln Val Arg Gly Val Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  252
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  252

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Lys Lys Arg Arg Thr Val Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  253
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  253

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Gln Arg Gly Leu Ala Leu Phe Gln His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  254
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  254

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Leu Ser Val Pro Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  255
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  255

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Trp Ile Arg Val Pro Leu Arg Leu Pro Leu Phe Gln His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  256
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  256

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Thr Ile Phe Ala Ile Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  257
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  257

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Arg Gly Phe Val His Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  258
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  PA2.1.14 scFv LIR1 HTICD

<400>  258
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggacg aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagcc      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa atacggctca cagagctcca aaccctacct gctgactcac      780

cccagtgacc ccctggagct cgtggtctca ggaccgtctg ggggccccag ctccccgaca      840

acaggcccca cctccacatc tggccctgag gaccagcccc tcacccccac cgggtcggat      900

ccccagagtg gtctgggaag gcacctgggg gttgtgatcg gcatcttggt ggccgtcatc      960

ctactgctcc tcctcctcct cctcctcttc ctcatcctcc gacatcgacg tcagggcaaa     1020

cactggacat cgacccagag aaaggctgat ttccaacatc ctgcaggggc tgtggggcca     1080

gagcccacag acagaggcct gcagtggagg tccagcccag ctgccgatgc ccaggaagaa     1140

aacctctatg ctgccgtgaa gcacacacag cctgaggatg gggtggagat ggacactcgg     1200

agcccacacg atgaagaccc ccaggcagtg acgtatgccg aggtgaaaca ctccagacct     1260

aggagagaaa tggcctctcc tccttcccca ctgtctgggg aattcctgga cacaaaggac     1320

agacaggcgg aagaggacag gcagatggac actgaggctg ctgcatctga agccccccag     1380

gatgtgacct acgcccagct gcacagcttg accctcagac gggaggcaac tgagcctcct     1440

ccatcccagg aagggccctc tccagctgtg cccagcatct acgccactct ggccatccac     1500

tag                                                                   1503


<210>  259
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  259

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Arg Gly Leu Cys Val Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  260
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  260

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Pro Ser Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  261
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  261

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Ile Tyr Met Gly Gly Ile Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  262
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  262

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Val Arg Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  263
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  263

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Thr Ala His Leu Asp Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  264
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  264

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ile Phe Pro Val Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  265
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  265

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Arg Lys Tyr Gly Tyr Val Phe Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  266
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  266

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Arg Tyr Arg Arg Phe Trp His Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  267
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  267

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala His Ile Arg Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  268
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  268

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Met Gly Gly Gly Gly Arg Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  269
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  269

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Arg Thr Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  270
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  270

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Met Gly Gly Gly Gly Arg Leu Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  271
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  271

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Gly Arg Leu Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  272
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  272

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ile Arg Gln Leu Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  273
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  273

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Phe Ala Asn Ser Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  274
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  274

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Asp Arg Thr Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  275
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  275

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Trp Gly Lys Asp Gly Pro Tyr Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  276
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  276

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Arg Asp Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  277
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  277

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Arg Pro Pro Pro Gly Tyr Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  278
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable fragment

<400>  278

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Arg Phe Ser Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  279
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain variable fragment

<400>  279

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  280
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain variable fragment

<400>  280

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  281
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain variable fragment

<400>  281

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  282
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain variable fragment

<400>  282

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  283
<211>  42
<212>  PRT
<213>  Unknown

<220>  
<223>  4-1BB co-stimulatory domain

<400>  283

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  284
<211>  126
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes 4-1BB co-stimulatory domain

<400>  284
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag gccagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  285
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CAR intracellular domain

<400>  285

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        35                  40                  45              


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    50                  55                  60                  


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
65                  70                  75                  80  


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                85                  90                  95      


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            100                 105                 110         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        115                 120                 125             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    130                 135                 140                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
145                 150                 155                 160 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                165                 170                 175     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            180                 185                 190         


Pro Pro Arg 
        195 


<210>  286
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  286

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Leu Pro Lys Leu Arg Asn Phe His Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
    290                 295                 300                 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
305                 310                 315                 320 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                325                 330                 335     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            340                 345                 350         


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        355                 360                 365             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    370                 375                 380                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


<210>  287
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  287

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Glu Tyr His Gly Phe Arg Gln Tyr Gly Leu Arg Tyr Trp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
                245                 250                 255     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            260                 265                 270         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        275                 280                 285             


Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    290                 295                 300                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
305                 310                 315                 320 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                325                 330                 335     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            340                 345                 350         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        355                 360                 365             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    370                 375                 380                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
385                 390                 395                 400 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                405                 410                 415     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            420                 425                 430         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        435                 440                 445             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    450                 455                 460                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
465                 470                 475                 480 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                485                 490                 495     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            500                 505                 510         


Pro Pro Arg 
        515 


<210>  288
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  288

Gln Leu Gln Leu Gln Glu Ser Gly Ser Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Ser Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Ile Lys Phe Trp Phe Ala Gly Ile Asn Tyr Phe Phe Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
    290                 295                 300                 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
305                 310                 315                 320 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
                325                 330                 335     


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            340                 345                 350         


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu 
        355                 360                 365             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    370                 375                 380                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
385                 390                 395                 400 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
                405                 410                 415     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            420                 425                 430         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        435                 440                 445             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    450                 455                 460                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
465                 470                 475                 480 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                485                 490                 495     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            500                 505                 510         


Pro Arg 
        


<210>  289
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  289

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Phe Leu Gly Met Gly Ser Asn Phe Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  290
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  290

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Leu Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Gly Asp Arg Ala Arg Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  291
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  291

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Pro Arg Gly Tyr His Gln Met Val Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
    290                 295                 300                 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
305                 310                 315                 320 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
                325                 330                 335     


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            340                 345                 350         


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu 
        355                 360                 365             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    370                 375                 380                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
385                 390                 395                 400 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
                405                 410                 415     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            420                 425                 430         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        435                 440                 445             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    450                 455                 460                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
465                 470                 475                 480 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                485                 490                 495     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            500                 505                 510         


Pro Arg 
        


<210>  292
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  292

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Arg Phe Leu Ala Ala Arg Thr Thr Ile Pro Glu Ala 
            100                 105                 110         


Asn Phe Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly 
    290                 295                 300                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
305                 310                 315                 320 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                325                 330                 335     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            340                 345                 350         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys 
        355                 360                 365             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    370                 375                 380                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
385                 390                 395                 400 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                405                 410                 415     


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            420                 425                 430         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        435                 440                 445             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    450                 455                 460                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
465                 470                 475                 480 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                485                 490                 495     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            500                 505                 510         


Ala Leu Pro Pro Arg 
        515         


<210>  293
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  293

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Arg Ala Arg Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  294
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  294

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Gly Arg Val Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        355                 360                 365             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    370                 375                 380                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  295
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  295

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Lys Phe Thr Ser Phe Leu Tyr Val His Gly Phe Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
    290                 295                 300                 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
305                 310                 315                 320 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
                325                 330                 335     


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            340                 345                 350         


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu 
        355                 360                 365             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    370                 375                 380                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
385                 390                 395                 400 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
                405                 410                 415     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            420                 425                 430         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        435                 440                 445             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    450                 455                 460                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
465                 470                 475                 480 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                485                 490                 495     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            500                 505                 510         


Pro Arg 
        


<210>  296
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  296

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Arg Trp Leu Tyr Leu Gly Gly Ile Arg Arg His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  297
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  297

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Trp Ile Pro Ser Arg Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  298
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  298

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Thr Gly Thr Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  299
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  299

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Arg Tyr Arg Arg Val Leu His Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  300
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  300

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
                245                 250                 255     


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            260                 265                 270         


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        275                 280                 285             


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    290                 295                 300                 


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
305                 310                 315                 320 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                325                 330                 335     


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            340                 345                 350         


Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        355                 360                 365             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    370                 375                 380                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
385                 390                 395                 400 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                405                 410                 415     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            420                 425                 430         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        435                 440                 445             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    450                 455                 460                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
465                 470                 475                 480 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                485                 490                 495     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505         


<210>  301
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  301

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu His Met Gly Thr Ile Pro Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  302
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  302

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Glu Phe Gly Tyr Gly Asp Val Leu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  303
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  303

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Asp Val Val Lys Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  304
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  304

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Phe Ser His Lys Leu Gly Tyr Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
    290                 295                 300                 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
305                 310                 315                 320 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                325                 330                 335     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            340                 345                 350         


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        355                 360                 365             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    370                 375                 380                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


<210>  305
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  305

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Tyr Val Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
145                 150                 155                 160 


Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
    210                 215                 220                 


Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Thr 
225                 230                 235                 240 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
                245                 250                 255     


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
            260                 265                 270         


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val 
        275                 280                 285             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    290                 295                 300                 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys 
            340                 345                 350         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        355                 360                 365             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    370                 375                 380                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
385                 390                 395                 400 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                405                 410                 415     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            420                 425                 430         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        435                 440                 445             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    450                 455                 460                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
465                 470                 475                 480 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                485                 490                 495     


Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505 


<210>  306
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  306

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Arg Asp Trp Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  307
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  307

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gln Ala Leu Lys Tyr Arg Val Asp Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  308
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  308

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Thr Leu Gly Cys Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  309
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  309

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Ser Asn Ser Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  310
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  310

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Phe Leu Phe Leu Ser Phe Ser Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  311
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  311

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ile Phe Tyr Ser Ser Lys Glu Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
    290                 295                 300                 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
305                 310                 315                 320 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                325                 330                 335     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            340                 345                 350         


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        355                 360                 365             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    370                 375                 380                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


<210>  312
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  312

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Trp Ile Phe Tyr Ser Ser Asn Pro Lys Pro Thr Val 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
                245                 250                 255     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            260                 265                 270         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        275                 280                 285             


Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    290                 295                 300                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
305                 310                 315                 320 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                325                 330                 335     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            340                 345                 350         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        355                 360                 365             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    370                 375                 380                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
385                 390                 395                 400 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                405                 410                 415     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            420                 425                 430         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        435                 440                 445             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    450                 455                 460                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
465                 470                 475                 480 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                485                 490                 495     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            500                 505                 510         


Pro Pro Arg 
        515 


<210>  313
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  313

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Phe Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Asp Gln Thr Leu Thr Tyr Gly Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  314
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  314

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp His Tyr Glu Arg Gly Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  315
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  315

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Met Tyr Asn Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  316
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  316

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Pro Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        355                 360                 365             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    370                 375                 380                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  317
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  317

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val His Leu Lys Arg Arg Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  318
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  318

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Val His Lys Lys Pro Ile Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  319
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  319

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Arg Arg Cys Thr Phe Gln His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  320
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  320

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Pro Arg Pro Leu Phe Gln His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  321
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  321

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Gln Val Arg Gly Val Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  322
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  322

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Lys Lys Arg Arg Thr Val Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  323
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  323

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Gln Arg Gly Leu Ala Leu Phe Gln His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  324
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  324

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Leu Ser Val Pro Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  325
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  325

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Trp Ile Arg Val Pro Leu Arg Leu Pro Leu Phe Gln His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
    290                 295                 300                 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
305                 310                 315                 320 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
                325                 330                 335     


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            340                 345                 350         


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu 
        355                 360                 365             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    370                 375                 380                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
385                 390                 395                 400 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
                405                 410                 415     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            420                 425                 430         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        435                 440                 445             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    450                 455                 460                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
465                 470                 475                 480 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                485                 490                 495     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            500                 505                 510         


Pro Arg 
        


<210>  326
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  326

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Thr Ile Phe Ala Ile Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  327
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  327

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Arg Gly Phe Val His Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  328
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  328

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Arg Gly Leu Cys Val Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  329
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  329

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Pro Ser Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  330
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  330

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Ile Tyr Met Gly Gly Ile Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  331
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  331

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Val Arg Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  332
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  332

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Thr Ala His Leu Asp Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  333
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  333

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ile Phe Pro Val Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  334
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  334

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Arg Lys Tyr Gly Tyr Val Phe Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  335
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  335

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Arg Tyr Arg Arg Phe Trp His Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  336
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  336

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala His Ile Arg Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  337
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  337

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Met Gly Gly Gly Gly Arg Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
    290                 295                 300                 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
305                 310                 315                 320 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                325                 330                 335     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            340                 345                 350         


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        355                 360                 365             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    370                 375                 380                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


<210>  338
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  338

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Arg Thr Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  339
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  339

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Met Gly Gly Gly Gly Arg Leu Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
    290                 295                 300                 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
305                 310                 315                 320 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                325                 330                 335     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            340                 345                 350         


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        355                 360                 365             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    370                 375                 380                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


<210>  340
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  340

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Gly Arg Leu Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  341
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  341

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ile Arg Gln Leu Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  342
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  342

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Phe Ala Asn Ser Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  343
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  343

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Asp Arg Thr Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  344
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  344

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Trp Gly Lys Asp Gly Pro Tyr Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  345
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  345

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Arg Asp Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  346
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  346

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Arg Pro Pro Pro Gly Tyr Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
    290                 295                 300                 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
305                 310                 315                 320 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                325                 330                 335     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            340                 345                 350         


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        355                 360                 365             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    370                 375                 380                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


<210>  347
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  single chain variable fragment

<400>  347

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Arg Phe Ser Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  348
<211>  500
<212>  PRT
<213>  Unknown

<220>  
<223>  inhibitory receptor

<400>  348

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr 
                245                 250                 255     


Leu Leu Thr His Pro Ser Asp Pro Leu Glu Leu Val Val Ser Gly Pro 
            260                 265                 270         


Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly 
        275                 280                 285             


Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly 
    290                 295                 300                 


Leu Gly Arg His Leu Gly Val Val Ile Gly Ile Leu Val Ala Val Ile 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg 
                325                 330                 335     


Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln 
            340                 345                 350         


His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln 
        355                 360                 365             


Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala 
    370                 375                 380                 


Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg 
385                 390                 395                 400 


Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys 
                405                 410                 415     


His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser 
            420                 425                 430         


Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln 
        435                 440                 445             


Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr 
    450                 455                 460                 


Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro 
465                 470                 475                 480 


Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr 
                485                 490                 495     


Leu Ala Ile His 
            500 


<210>  349
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  B2M shRNA

<400>  349
gcactcaaag cttgttaaga tcgaaatctt aacaagcttt gagtgc                      46


<210>  350
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  B2M shRNA

<400>  350
gttaacttcc aatttacata ccgaagtatg taaattggaa gttaac                      46


<210>  351
<211>  21
<212>  PRT
<213>  Unknown

<220>  
<223>  T2A self-cleaving polypeptide

<400>  351

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  352
<211>  64
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  352

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


<210>  353
<211>  64
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  353

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


<210>  354
<211>  44
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  354

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
        35                  40                  


<210>  355
<211>  64
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  355

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


<210>  356
<211>  44
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  356

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
        35                  40                  


<210>  357
<211>  71
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  357

Ser Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro 
1               5                   10                  15      


Ser Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser 
            20                  25                  30          


Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro 
        35                  40                  45              


Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu 
    50                  55                  60                  


Gly Val Val Ile Gly Ile Leu 
65                  70      


<210>  358
<211>  39
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  358

Ser Ser Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro 
1               5                   10                  15      


Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu 
            20                  25                  30          


Gly Val Val Ile Gly Ile Leu 
        35                  


<210>  359
<211>  74
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  359

Ser Ser Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val 
1               5                   10                  15      


Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser 
            20                  25                  30          


Pro Ser Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val 
        35                  40                  45              


Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser 
    50                  55                  60                  


Pro Ser Ala Ser Val Val Ile Gly Ile Leu 
65                  70                  


<210>  360
<211>  82
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  360

Ser Ser Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val 
1               5                   10                  15      


Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr Pro Ser 
            20                  25                  30          


Pro Ser Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro 
        35                  40                  45              


Pro Thr Pro Ser Pro Ser Pro Val Pro Ser Thr Pro Pro Thr Asn Ser 
    50                  55                  60                  


Ser Ser Thr Pro Pro Thr Pro Ser Pro Ser Ala Ser Val Val Ile Gly 
65                  70                  75                  80  


Ile Leu 
        


<210>  361
<211>  92
<212>  PRT
<213>  Unknown

<220>  
<223>  HLA-A*02 scFv LIR-1 inhibitory receptor

<400>  361

Ser Ser Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr 
1               5                   10                  15      


Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr 
            20                  25                  30          


Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Val Val Ser Gly Pro 
        35                  40                  45              


Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly 
    50                  55                  60                  


Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly 
65                  70                  75                  80  


Leu Gly Arg His Leu Gly Val Val Ile Gly Ile Leu 
                85                  90          


<210>  362
<211>  22
<212>  PRT
<213>  Unknown

<220>  
<223>  signal sequence

<400>  362

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  363
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  363
caggtgcagc tggtgcagtc tggggctgag gtggagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gtctggctgg      300

gactttgact actggggcca gggaaccctg gtcaccgtgt cctcaggcgg aggtggaagc      360

ggagggggag gatctggcgg cggaggaagc ggaggcgaca tcgtgatgac ccagtcttcc      420

tccctgtctg catctgtcgg agacagagtc accatcactt gccgggccag tcagagcatt      480

aggtactatt taagttggta tcagcagaaa ccaggaaaag cccctaagct cctgatctat      540

actgcatcca ttttacaaaa tggggtccca tcaaggttca gtggcagtgg atctgggaca      600

gatttcactc tcaccatcag cagcctgcaa cctgaggatt ttgcaactta ttactgcctc      660

cagacttaca ctactccgga ctttggccca gggaccaagg tggaaatcaa a               711


<210>  364
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  364
caggtgcagc tggtgcagtc tggggctgag gtgagggcac ctggggcctc agtgaagatt       60

tcctgcaagg cttctggatt caccttcaga ggctactata tccactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatc atcaacccta gtggtggtag cagagcctac      180

gcacagaagt tccagggcag ggtcaccatg accagggaca cttccacgag cacagtctac      240

atggagctga gcagcctgag atctgacgac acggccatgt attactgtgc gagaaccgca      300

agttgtggtg gtgactgcta ctaccttgac tactggggcc agggaaccct ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgac      420

atccagatga cccagtctcc tcccaccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtgagaa tgttaatatc tggttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ctataagtca tccagtttag caagtggggt cccatcaagg      600

ttcagtggca gtggatctgg ggcagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagtat caaagttacc ccctcacttt cggcggaggg      720

accaaggtgg aaatcaaa                                                    738


<210>  365
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  365
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata ctcattcacc ggctacacca tgaactgggt gaggcaggcc      120

cctggacaaa gacttgagtg gatgggactt atcacccctt acaatggtgc ttctagctac      180

aaccagaagt tcaggggcag ggtcacaatc actagagaca cgtcagccag cacagcctac      240

atggagctct ccagcctgag atctgaagac actgcagtct attactgtgc aagggggggt      300

tacgacggga ggggttttga ctactggggc cagggaacca cggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc cttcaagctt gtctgcatct gtaggagaca gggtcaccat cacttgcagt      480

gccagctcaa gtgtaagtta catgcactgg tatcagcaga aaccaggcaa ggcccctaag      540

agattgatct atgacacatc caaattagca agtggggtcc caagtcgctt cagtggcagt      600

ggatctggga ccgaattcac tctcaccatc agcagcttgc agcctgagga ttttgcaact      660

tattactgcc agcagtggag tggttaccct ctcacgttcg gtcaggggac aaagttggaa      720

atcaaa                                                                 726


<210>  366
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  366
caggtgcagc tgcagcagtc tgggcctgag ctggagaagc ctggggcctc agtgaagatt       60

tcctgcaagg cttctggata ctcattcacc ggctacacca tgaactgggt gaagcagagc      120

catggaaaaa gccttgagtg gattggactt atcacccctt acaatggtgc ttctagctac      180

aaccagaagt tcaggggcaa ggccacatta actgtagaca agtcatccag cacagcctac      240

atggacctcc tcagcctgac atctgaagac tctgcagtct atttctgtgc aagggggggt      300

tacgacggga ggggttttga ctactggggc cagggaacca cggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catcgagctc      420

acccagtctc ctgcaatcat gtctgcatct ccaggagaga aggtcaccat gacttgcagt      480

gccagctcaa gtgtaagtta catgcactgg tatcagcaga aatcaggcac ctcccctaag      540

agatggatct atgacacatc caaattggca agtggggtcc caggtcgctt cagtggcagt      600

ggatctggga actcttactc tctcaccatc agcagcgtgg aggctgagga tgatgcaact      660

tattactgcc agcagtggag tggttaccct ctcacgttcg gtgctgggac aaagttggaa      720

atcaaa                                                                 726


<210>  367
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  367
gaagtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttctcg aacgcctgga tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtcggacgg atcaagagca agaccgacgg cggcaccacc      180

gactacgctg cccccgtgaa gggccggttc accatcagcc gggacgacag caagaacacc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtatta ctgtaccaca      300

gatcttccta agcttaggaa ttttcatatt tggggccagg gaaccctggt caccgtgtcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgacatc      420

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      480

tgccgggcaa gtcagagcat tagcagctat ttaaattggt atcagcagaa accagggaaa      540

gcccctaagc tcctgatcta tgctgcatcc agtttgcaaa gtggggtccc atcaaggttc      600

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      660

tttgcaactt actactgtca acagagttac agtacccctc tcactttcgg cggcggaaca      720

aaggtggaga tcaag                                                       735


<210>  368
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  368
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaata cgtgtccgcc atcagctcga acggcggcag cacctactac      180

gccaacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatgg gcagcctgcg ggccgaggat atggccgtgt attactgtgc gagcctagaa      300

taccatggct ttcgacaata tgggcttcgt tattggcatt ggggccaggg aaccctggtc      360

accgtgtcct caggcggagg tggaagcgga gggggaggat ctggcggcgg aggaagcgga      420

ggcgacatcc agatgaccca gtctccatcc tccctgtctg catctgtagg agacagagtc      480

accatcactt gccgggcaag tcagagcatt agcagctatt taaattggta tcagcagaaa      540

ccagggaaag cccctaagct cctgatctat gctgcatcca gtttgcaaag tggggtccca      600

tcaaggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcaa      660

cctgaagatt ttgcaactta ctactgtcaa cagagttaca gtacccctct cactttcggc      720

ggcggaacaa aggtggagat caag                                             744


<210>  369
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  369
cagctgcagc tccaggaaag cggcagcggc ctggtgaaac ccagccagac cctgagcctg       60

acctgtgccg tgtccggcgg cagcatcagc agcggcggct acagctggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct accacagcgg ctcgacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acagaagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgccagcata      300

aaattctggt ttgcggggat taattatttt tttccgtggg gccagggaac cctggtcacc      360

gtgtcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      420

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      480

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      540

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      600

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      660

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      720

ggaacaaagg tggagatcaa g                                                741


<210>  370
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  370
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctactgga tgcactgggt ccgccaggcc      120

cctggcaagg gactggtctg ggtgtctcga atcaacagcg acggcagcag caccagctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc aagcggattt      300

ttgggaatgg gctcgaattt tatttggggc cagggaaccc tggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  371
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  371
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg cagcatcagc agcggcggct actactggtc ctggatcaga      120

cagcaccccg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cctggtgaca atctccgtcg ataccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcaagcggg      300

gacagggcac ggtacttcga tctctggggc cgtggcaccc tggtcactgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  372
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  372
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctactgga tgcactgggt ccgccaggcc      120

cctggcaagg gactggtctg ggtgtctcga atcaacagcg acggcagcag caccagctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc aagatatcca      300

cgtggatatc atcagatggt tgatgctttt gatatctggg gccaagggac aatggtcacc      360

gtgtcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      420

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      480

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      540

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      600

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      660

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      720

ggaacaaagg tggagatcaa g                                                741


<210>  373
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  373
cagctgcagc tccaggaaag cggccctggc ctggtgaaac ccagcgagac actgagcctg       60

acctgcaccg tgtccggcgg cagcatcagc agcagcagct actactgggg ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctcgatct actacagcgg ctccacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagagta      300

cgatttttgg ctgctcgcac tactattccg gaggcgaatt ttctttgggg ccagggaacc      360

ctggtcaccg tgtcctcagg cggaggtgga agcggagggg gaggatctgg cggcggagga      420

agcggaggcg acatccagat gacccagtct ccatcctccc tgtctgcatc tgtaggagac      480

agagtcacca tcacttgccg ggcaagtcag agcattagca gctatttaaa ttggtatcag      540

cagaaaccag ggaaagcccc taagctcctg atctatgctg catccagttt gcaaagtggg      600

gtcccatcaa ggttcagtgg cagtggatct gggacagatt tcactctcac catcagcagt      660

ctgcaacctg aagattttgc aacttactac tgtcaacaga gttacagtac ccctctcact      720

ttcggcggcg gaacaaaggt ggagatcaag                                       750


<210>  374
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  374
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacagca tgaactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcagctccac catctactac      180

gccgacagcg tgaagggtcg attcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagtactc      300

tccagggcta ggtttgacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      480

agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagagtta cagtacccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  375
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  375
gaagtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc agctacagca tgaactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtcctcg atcagcagca gcagctccta catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagattacga      300

gggagggtgt tcgacccctg gggccaggga accctggtca ccgtgtcctc aggcggaggt      360

ggaagcggag ggggaggatc tggcggcgga ggaagcggag gcgacatcca gatgacccag      420

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt      480

cagagcatta gcagctattt aaattggtat cagcagaaac cagggaaagc ccctaagctc      540

ctgatctatg ctgcatccag tttgcaaagt ggggtcccat caaggttcag tggcagtgga      600

tctgggacag atttcactct caccatcagc agtctgcaac ctgaagattt tgcaacttac      660

tactgtcaac agagttacag tacccctctc actttcggcg gcggaacaaa ggtggagatc      720

aag                                                                    723


<210>  376
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  376
cagctgcagc tccaggaaag cggccctggc ctggtgaaac ccagcgagac actgagcctg       60

acctgcaccg tgtccggcgg cagcatcagc agcagcagct actactgggg ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctcgatct actacagcgg ctccacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagaata      300

aaatttacca gctttttata tgttcatggt tttctgtggg gccagggaac cctggtcacc      360

gtgtcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      420

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      480

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      540

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      600

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      660

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      720

ggaacaaagg tggagatcaa g                                                741


<210>  377
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  377
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacgcca tgcactgggt tcgacaggcc      120

cctggccaga gactggaatg gatgggctgg atcaacgccg gcaacggcaa caccaagtac      180

agccagaaat tccagggcag agtgaccatc acccgggaca ccagcgccag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgctgtgt attactgtgc gagaggccag      300

agatggctgt acctcggggg gattcgtcgg cattggggcc agggaaccct ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgac      420

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg caagtcagag cattagcagc tatttaaatt ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ctatgctgca tccagtttgc aaagtggggt cccatcaagg      600

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa      660

gattttgcaa cttactactg tcaacagagt tacagtaccc ctctcacttt cggcggcgga      720

acaaaggtgg agatcaag                                                    738


<210>  378
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  378
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagcgagac actgagcctg       60

acctgcaccg tgtccggcgg cagcatcagc agctactact ggtcctggat cagacagccc      120

cctggcaagg gcctggaatg gatcggctac atctactaca gcggcagcac caactacaac      180

cccagcctga agtccagagt gaccatctcc gtcgatacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgacagc cgccgacacc gctgtgtatt actgtgcgag agaatggatt      300

cccagccgtc cgtactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      480

cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc agggaaagcc      540

cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt      600

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc tgaagatttt      660

gcaacttact actgtcaaca gagttacagt acccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  379
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  379
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagagaa      300

agtaccggta caggagcttt tgatatctgg ggccaaggga caatggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      480

cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc agggaaagcc      540

cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt      600

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc tgaagatttt      660

gcaacttact actgtcaaca gagttacagt acccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  380
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  380
gaagtgcagc tggtggaaag cggaggcgga gtggttcgac ctggcggaag cctgagactg       60

tcttgcgccg ccagcggctt cacctttgac gactacggca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcaactgga acggcggcag caccggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt atcactgtgc gagagagagg      300

tacaggcggg tactccactg gtacttcgat ctctggggcc gtggcaccct ggtcactgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgac      420

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg caagtcagag cattagcagc tatttaaatt ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ctatgctgca tccagtttgc aaagtggggt cccatcaagg      600

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa      660

gattttgcaa cttactactg tcaacagagt tacagtaccc ctctcacttt cggcggcgga      720

acaaaggtgg agatcaag                                                    738


<210>  381
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  381
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacgaca tcaactgggt ccgccaggcc      120

accggacagg gcctggaatg gatgggctgg atgaacccca acagcggcaa caccggctac      180

gcccagaaat tccagggcag agtgaccatg acccggaaca cctcgatcag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgctgtgt attactgtgc gagagaaccg      300

gatgcttttg atatctgggg ccaagggaca atggtcaccg tgtcctcagg cggaggtgga      360

agcggagggg gaggatctgg cggcggagga agcggaggcg acatccagat gacccagtct      420

ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgccg ggcaagtcag      480

agcattagca gctatttaaa ttggtatcag cagaaaccag ggaaagcccc taagctcctg      540

atctatgctg catccagttt gcaaagtggg gtcccatcaa ggttcagtgg cagtggatct      600

gggacagatt tcactctcac catcagcagt ctgcaacctg aagattttgc aacttactac      660

tgtcaacaga gttacagtac ccctctcact ttcggcggcg gaacaaaggt ggagatcaag      720


<210>  382
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  382
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagagaa      300

catatgggga cgattccgta ctactttgac tactggggcc agggaaccct ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgac      420

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg caagtcagag cattagcagc tatttaaatt ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ctatgctgca tccagtttgc aaagtggggt cccatcaagg      600

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa      660

gattttgcaa cttactactg tcaacagagt tacagtaccc ctctcacttt cggcggcgga      720

acaaaggtgg agatcaag                                                    738


<210>  383
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  383
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg ctcgatcagc agcggcggct actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagagaa      300

gagtttggtt atggggacgt cctctactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      480

cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc agggaaagcc      540

cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt      600

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc tgaagatttt      660

gcaacttact actgtcaaca gagttacagt acccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  384
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  384
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg cagcatcagc agcggcgact actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc tcgagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgccagagag      300

gacgtagtca aaggcgcttt tgatatctgg ggccaaggga caatggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      480

cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc agggaaagcc      540

cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt      600

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc tgaagatttt      660

gcaacttact actgtcaaca gagttacagt acccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  385
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  385
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacagca tgaactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcagctccac catctactac      180

gccgacagcg tgaagggtcg attcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagaagac      300

ttctcgcata agctagggta cttccagcac tggggccagg gcaccctggt caccgtgtcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgacatc      420

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      480

tgccgggcaa gtcagagcat tagcagctat ttaaattggt atcagcagaa accagggaaa      540

gcccctaagc tcctgatcta tgctgcatcc agtttgcaaa gtggggtccc atcaaggttc      600

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      660

tttgcaactt actactgtca acagagttac agtacccctc tcactttcgg cggcggaaca      720

aaggtggaga tcaag                                                       735


<210>  386
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  386
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagattac      300

gattacgtgt ggggccaggg aaccctggtc accgtgtcct caggcggagg tggaagcgga      360

gggggaggat ctggcggcgg aggaagcgga ggcgacatcc agatgaccca gtctccatcc      420

tccctgtctg catctgtagg agacagagtc accatcactt gccgggcaag tcagagcatt      480

agcagctatt taaattggta tcagcagaaa ccagggaaag cccctaagct cctgatctat      540

gctgcatcca gtttgcaaag tggggtccca tcaaggttca gtggcagtgg atctgggaca      600

gatttcactc tcaccatcag cagtctgcaa cctgaagatt ttgcaactta ctactgtcaa      660

cagagttaca gtacccctct cactttcggc ggcggaacaa aggtggagat caag            714


<210>  387
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  387
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagccagac cctgagcctg       60

acctgcacag tgtccggcgg cagcatcagc agcggcgact actactggtc ctggatcaga      120

cagccccctg gcaagggcct ggaatggatc ggctacatct actacagcgg cagcacctac      180

tacaacccca gcctgaagtc tcgagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgccagagat      300

cgccgtgatt gggactggtt cgacccctgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      480

cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc agggaaagcc      540

cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt      600

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc tgaagatttt      660

gcaacttact actgtcaaca gagttacagt acccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  388
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  388
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagcggcac cctgagcctg       60

acctgtgccg tgtctggcgg cagcatcagc agcagcaact ggtggtcctg ggtccgccag      120

cctcccggca agggcctcga atggatcggc gagatctacc acagcggcag caccaactac      180

aaccccagcc tgaagtccag agtgaccatc agcgtggaca agagcaagaa ccagttcagc      240

ctgaagctga gcagcgtgac agccgccgac accgctgtgt attactgtgc gagagatcag      300

caggcgttga aataccgtgt ggattggggc cagggaaccc tggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  389
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  389
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacggca tcagctgggt ccgccaggct      120

cctggacagg gactggaatg gatgggctgg atcagcgcct acaacggcaa caccaactac      180

gcccagaaac tgcagggcag agtgaccatg accaccgaca ccagcaccag caccgcctac      240

atggaacttc gaagcctgag aagcgacgac accgccgtgt attactgtgc gagagatctt      300

acgctaggat gctttgacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      480

agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagagtta cagtacccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  390
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  390
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccgtgtcc agcaactaca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccgtg atctacagcg gcggcagcac ctactacgcc      180

gacagcgtga agggtcgatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgcgggc cgaggacacc gccgtgtatt actgtgcgag agatgggtca      300

aactcttggt acttcgatct ctggggccgt ggcaccctgg tcactgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      480

agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagagtta cagtacccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  391
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  391
caggtgcagc tggtggaaag cggcggaggc gtggtgcagc ccggcagaag ccttcgactg       60

agctgcgccg ccagcggctt caccttcagc agctacggca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtggccgtg atttggtacg acggcagcaa caagtactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagggcattt      300

ttattcctgt ctttttcggt ttggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      480

agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagagtta cagtacccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  392
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  392
gaagtgcagc tggtggaatc tggcggcgtg gtggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcgac gactacacca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccctg atcagctggg acggcggctc tacctactac      180

gccgactccg tgaagggccg gttcaccatc agccgggaca acagcaagaa cagcctgtac      240

ctgcagatga acagcctgcg gaccgaggac accgccttgt attactgtgc aaaagggata      300

ttctactcga gtaaagagga ttttgactac tggggccagg gaaccctggt caccgtgtcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgacatc      420

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      480

tgccgggcaa gtcagagcat tagcagctat ttaaattggt atcagcagaa accagggaaa      540

gcccctaagc tcctgatcta tgctgcatcc agtttgcaaa gtggggtccc atcaaggttc      600

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      660

tttgcaactt actactgtca acagagttac agtacccctc tcactttcgg cggcggaaca      720

aaggtggaga tcaag                                                       735


<210>  393
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  393
gaagtgcagc tggtggaatc tggcggcgtg gtggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcgac gactacacca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccctg atcagctggg acggcggctc tacctactac      180

gccgactccg tgaagggccg gttcaccatc agccgggaca acagcaagaa cagcctgtac      240

ctgcagatga acagcctgcg gaccgaggac accgccttgt attactgtgc aaaagatata      300

tggatattct actcgagtaa tccaaagccg acggtctact ggggccaggg aaccctggtc      360

accgtgtcct caggcggagg tggaagcgga gggggaggat ctggcggcgg aggaagcgga      420

ggcgacatcc agatgaccca gtctccatcc tccctgtctg catctgtagg agacagagtc      480

accatcactt gccgggcaag tcagagcatt agcagctatt taaattggta tcagcagaaa      540

ccagggaaag cccctaagct cctgatctat gctgcatcca gtttgcaaag tggggtccca      600

tcaaggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcaa      660

cctgaagatt ttgcaactta ctactgtcaa cagagttaca gtacccctct cactttcggc      720

ggcggaacaa aggtggagat caag                                             744


<210>  394
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  394
caggtgcagc tggtgcagag cggcagcgag ctgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacgcca tgaactgggt ccgccaggcc      120

ccaggccagg gactggaatg gatgggctgg atcaacacca acaccggcaa ccccacctac      180

gcccagggct tcaccggcag attcgtgttc agcttcgaca ccagcgtgtc caccgcctac      240

ctgcagatct gtagcctgaa ggccgaggac accgccgtgt attactgtgc gaggaaggat      300

cagacgctga cctacggaaa ctggttcgac ccctggggcc agggaaccct ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgac      420

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg caagtcagag cattagcagc tatttaaatt ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ctatgctgca tccagtttgc aaagtggggt cccatcaagg      600

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa      660

gattttgcaa cttactactg tcaacagagt tacagtaccc ctctcacttt cggcggcgga      720

acaaaggtgg agatcaag                                                    738


<210>  395
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  395
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagcgagac actgagcctg       60

acctgcaccg tgtccggcgg ctctgtgtcc agcggctcct actactggtc ctggatcaga      120

cagccccctg gcaagggcct cgaatggatc ggctacatct actacagcgg cagcaccaac      180

tacaacccca gcctgaagtc cagagtgacc atcagcgtgg acaccagcaa gaaccagttc      240

agcctgaagc tgagcagcgt gacagccgcc gacaccgctg tgtattactg tgcgagagat      300

cattacgagc gggggctcta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      480

agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagagtta cagtacccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  396
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  396
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagatatatg      300

tataactggt acttcgatct ctggggccgt ggcaccctgg tcactgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagagcccca gcagcgtgtc cgccagcgtg ggcgatcgag tgaccatcac ctgtcgggcc      480

tcccagggca tcagcagctg gctggcctgg tatcagcaga agcccggcaa ggcccccaag      540

ctgctgatct acgccgccag cagcctgcag agcggcgtgc caagcagatt cagcggcagc      600

ggctccggca ccgacttcac cctgaccatc agctccctgc agcccgagga cttcgccacc      660

tactactgcc agcaggctaa cagtttccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  397
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  397
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagatcga      300

aggcctgctt ttgatatctg gggccaaggg acaatggtca ccgtgtcctc aggcggaggt      360

ggaagcggag ggggaggatc tggcggcgga ggaagcggag gcgacatcca gatgacccag      420

agccccagca gcgtgtccgc cagcgtgggc gatcgagtga ccatcacctg tcgggcctcc      480

cagggcatca gcagctggct ggcctggtat cagcagaagc ccggcaaggc ccccaagctg      540

ctgatctacg ccgccagcag cctgcagagc ggcgtgccaa gcagattcag cggcagcggc      600

tccggcaccg acttcaccct gaccatcagc tccctgcagc ccgaggactt cgccacctac      660

tactgccagc aggctaacag tttccctctc actttcggcg gcggaacaaa ggtggagatc      720

aag                                                                    723


<210>  398
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  398
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc ggtacatttg      300

aaacgacgtc cctactttga ctactggggc cagggaaccc tggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgata gagtgaccat cacctgtcgc      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc cagctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taatagttac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  399
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  399
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagcgtacat      300

aagaaaccca tctttgacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgccat ccagctgacc      420

cagagcccca gcagcctgag cgccagcgtg ggcgatagag tgaccatcac ctgtcgcgcc      480

agccagggca tcagcagcgc tctggcctgg tatcagcaga agcccggcaa ggcccccaag      540

ctgctgatct acgacgccag ctccctggaa agcggcgtgc ccagcagatt cagcggcagc      600

ggctccggca ccgacttcac cctgaccatc agcagcctgc agcccgagga cttcgccacc      660

tactactgcc agcagtttaa tagttaccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  400
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  400
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagtaccagt      300

cggcgctgta ccttccagca ctggggccag ggcaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgccat ccagctgacc      420

cagagcccca gcagcctgag cgccagcgtg ggcgatagag tgaccatcac ctgtcgcgcc      480

agccagggca tcagcagcgc tctggcctgg tatcagcaga agcccggcaa ggcccccaag      540

ctgctgatct acgacgccag ctccctggaa agcggcgtgc ccagcagatt cagcggcagc      600

ggctccggca ccgacttcac cctgaccatc agcagcctgc agcccgagga cttcgccacc      660

tactactgcc agcagtttaa tagttaccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  401
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  401
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagtaccagc      300

ccgcgtcctc tcttccagca ctggggccag ggcaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgccat ccagctgacc      420

cagagcccca gcagcctgag cgccagcgtg ggcgatagag tgaccatcac ctgtcgcgcc      480

agccagggca tcagcagcgc tctggcctgg tatcagcaga agcccggcaa ggcccccaag      540

ctgctgatct acgacgccag ctccctggaa agcggcgtgc ccagcagatt cagcggcagc      600

ggctccggca ccgacttcac cctgaccatc agcagcctgc agcccgagga cttcgccacc      660

tactactgcc agcagtttaa tagttaccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  402
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  402
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagcccttac      300

caagtccgag gagtctactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgccatccag      420

ctgacccaga gccccagcag cctgagcgcc agcgtgggcg atagagtgac catcacctgt      480

cgcgccagcc agggcatcag cagcgctctg gcctggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacga cgccagctcc ctggaaagcg gcgtgcccag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gtttaatagt taccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  403
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  403
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagcccctat      300

aagaaacgac gaacggtctt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgccatccag      420

ctgacccaga gccccagcag cctgagcgcc agcgtgggcg atagagtgac catcacctgt      480

cgcgccagcc agggcatcag cagcgctctg gcctggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacga cgccagctcc ctggaaagcg gcgtgcccag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gtttaatagt taccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  404
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  404
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gtctttacag      300

cgcgggctgg ccctcttcca gcactggggc cagggcaccc tggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgata gagtgaccat cacctgtcgc      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc cagctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taatagttac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  405
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  405
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc tagcatattg      300

tcagttccgt acttcgatct ctggggccgt ggcaccctgg tcactgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgccat ccagctgacc      420

cagagcccca gcagcctgag cgccagcgtg ggcgatagag tgaccatcac ctgtcgcgcc      480

agccagggca tcagcagcgc tctggcctgg tatcagcaga agcccggcaa ggcccccaag      540

ctgctgatct acgacgccag ctccctggaa agcggcgtgc ccagcagatt cagcggcagc      600

ggctccggca ccgacttcac cctgaccatc agcagcctgc agcccgagga cttcgccacc      660

tactactgcc agcagtttaa tagttaccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  406
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  406
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagtgggtgg      300

attcgtgtac ctttacgatt gcccctcttc cagcactggg gccagggcac cctggtcacc      360

gtgtcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      420

gccatccagc tgacccagag ccccagcagc ctgagcgcca gcgtgggcga tagagtgacc      480

atcacctgtc gcgccagcca gggcatcagc agcgctctgg cctggtatca gcagaagccc      540

ggcaaggccc ccaagctgct gatctacgac gccagctccc tggaaagcgg cgtgcccagc      600

agattcagcg gcagcggctc cggcaccgac ttcaccctga ccatcagcag cctgcagccc      660

gaggacttcg ccacctacta ctgccagcag tttaatagtt accctctcac tttcggcggc      720

ggaacaaagg tggagatcaa g                                                741


<210>  407
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  407
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagtaacc      300

atatttgcga tatttgatat ctggggccaa gggacaatgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgccat ccagctgacc      420

cagagcccca gcagcctgag cgccagcgtg ggcgatagag tgaccatcac ctgtcgcgcc      480

agccagggca tcagcagcgc tctggcctgg tatcagcaga agcccggcaa ggcccccaag      540

ctgctgatct acgacgccag ctccctggaa agcggcgtgc ccagcagatt cagcggcagc      600

ggctccggca ccgacttcac cctgaccatc agcagcctgc agcccgagga cttcgccacc      660

tactactgcc agcagtttaa tagttaccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  408
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  408
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagtggga      300

cgtggattcg ttcattttga tctctggggc cgtggcaccc tggtcactgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgata gagtgaccat cacctgtcgc      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc cagctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taatagttac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  409
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  409
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gaggacgtca      300

agaggtttgt gtgttttatt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgccatccag      420

ctgacccaga gccccagcag cctgagcgcc agcgtgggcg atagagtgac catcacctgt      480

cgcgccagcc agggcatcag cagcgctctg gcctggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacga cgccagctcc ctggaaagcg gcgtgcccag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gtttaatagt taccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  410
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  410
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagaagtggg      300

cccagtagct actggtactt cgatctctgg ggccgtggca ccctggtcac tgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgccatccag      420

ctgacccaga gccccagcag cctgagcgcc agcgtgggcg atagagtgac catcacctgt      480

cgcgccagcc agggcatcag cagcgctctg gcctggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacga cgccagctcc ctggaaagcg gcgtgcccag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gtttaatagt taccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  411
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  411
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagaaacatt      300

tacatgggcg ggatctggtt cgacccctgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgccatccag      420

ctgacccaga gccccagcag cctgagcgcc agcgtgggcg atagagtgac catcacctgt      480

cgcgccagcc agggcatcag cagcgctctg gcctggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacga cgccagctcc ctggaaagcg gcgtgcccag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gtttaatagt taccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  412
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  412
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagacttaca      300

gtccgcactg gagcttttga tatctggggc caagggacaa tggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgata gagtgaccat cacctgtcgc      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc cagctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taatagttac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  413
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  413
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagactaaga      300

actgcccacc tggacttcga tctctggggc cgtggcaccc tggtcactgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgata gagtgaccat cacctgtcgc      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc cagctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taatagttac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  414
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  414
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagatctc      300

atatttccag tagtctttga ctactggggc cagggaaccc tggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgata gagtgaccat cacctgtcgc      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc cagctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taatagttac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  415
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  415
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagatgga      300

tatcgcaaat atggttacgt attttttgat atctggggcc aagggacaat ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgcc      420

atccagctga cccagagccc cagcagcctg agcgccagcg tgggcgatag agtgaccatc      480

acctgtcgcg ccagccaggg catcagcagc gctctggcct ggtatcagca gaagcccggc      540

aaggccccca agctgctgat ctacgacgcc agctccctgg aaagcggcgt gcccagcaga      600

ttcagcggca gcggctccgg caccgacttc accctgacca tcagcagcct gcagcccgag      660

gacttcgcca cctactactg ccagcagttt aatagttacc ctctcacttt cggcggcgga      720

acaaaggtgg agatcaag                                                    738


<210>  416
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  416
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagatggg      300

aggtacaggc ggttctggca tgcttttgat atctggggcc aagggacaat ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgcc      420

atccagctga cccagagccc cagcagcctg agcgccagcg tgggcgatag agtgaccatc      480

acctgtcgcg ccagccaggg catcagcagc gctctggcct ggtatcagca gaagcccggc      540

aaggccccca agctgctgat ctacgacgcc agctccctgg aaagcggcgt gcccagcaga      600

ttcagcggca gcggctccgg caccgacttc accctgacca tcagcagcct gcagcccgag      660

gacttcgcca cctactactg ccagcagttt aatagttacc ctctcacttt cggcggcgga      720

acaaaggtgg agatcaag                                                    738


<210>  417
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  417
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc gagagcccat      300

atacgggggt acttcgatct ctggggccgt ggcaccctgg tcactgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgccat ccagctgacc      420

cagagcccca gcagcctgag cgccagcgtg ggcgatagag tgaccatcac ctgtcgcgcc      480

agccagggca tcagcagcgc tctggcctgg tatcagcaga agcccggcaa ggcccccaag      540

ctgctgatct acgacgccag ctccctggaa agcggcgtgc ccagcagatt cagcggcagc      600

ggctccggca ccgacttcac cctgaccatc agcagcctgc agcccgagga cttcgccacc      660

tactactgcc agcagtttaa tagttaccct ctcactttcg gcggcggaac aaaggtggag      720

atcaag                                                                 726


<210>  418
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  418
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gacgtggatg      300

gggggcgggg gacgatggta cttcgatctc tggggccgtg gcaccctggt cactgtgtcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgccatc      420

cagctgaccc agagccccag cagcctgagc gccagcgtgg gcgacagagt gaccatcacc      480

tgtcgggcca gccagggcat cagcagcgct ctggcctggt atcagcagaa gcccggcaag      540

gcccccaagc tgctgatcta cgacgcgtcc tccctggaaa gcggcgtgcc cagcagattc      600

agcggcagcg gctccggcac cgacttcacc ctgaccatca gcagcctgca gcccgaggac      660

ttcgccacct actactgcca gcagtttaat aattaccctc tcactttcgg cggcggaaca      720

aaggtggaga tcaag                                                       735


<210>  419
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  419
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gagaactagt      300

cgtacaacct ggtacttcga tctctggggc cgtggcaccc tggtcactgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgaca gagtgaccat cacctgtcgg      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc gtcctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taataattac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  420
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  420
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gaaatggatg      300

gggggcgggg gacgattata cttcgatctc tggggccgtg gcaccctggt cactgtgtcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgccatc      420

cagctgaccc agagccccag cagcctgagc gccagcgtgg gcgacagagt gaccatcacc      480

tgtcgggcca gccagggcat cagcagcgct ctggcctggt atcagcagaa gcccggcaag      540

gcccccaagc tgctgatcta cgacgcgtcc tccctggaaa gcggcgtgcc cagcagattc      600

agcggcagcg gctccggcac cgacttcacc ctgaccatca gcagcctgca gcccgaggac      660

ttcgccacct actactgcca gcagtttaat aattaccctc tcactttcgg cggcggaaca      720

aaggtggaga tcaag                                                       735


<210>  421
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  421
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gaaatggggg      300

gggcggttgt actggtactt cgatctctgg ggccgtggca ccctggtcac tgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgccatccag      420

ctgacccaga gccccagcag cctgagcgcc agcgtgggcg acagagtgac catcacctgt      480

cgggccagcc agggcatcag cagcgctctg gcctggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacga cgcgtcctcc ctggaaagcg gcgtgcccag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gtttaataat taccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  422
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  422
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gaaagttatt      300

cggcaactct ggtacttcga tctctggggc cgtggcaccc tggtcactgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgaca gagtgaccat cacctgtcgg      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc gtcctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taataattac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  423
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  423
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gaaagttttc      300

gccaactcct ggtacttcga tctctggggc cgtggcaccc tggtcactgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgaca gagtgaccat cacctgtcgg      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc gtcctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taataattac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  424
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  424
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gaaagtagat      300

aggactacct ggtacttcga tctctggggc cgtggcaccc tggtcactgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgaca gagtgaccat cacctgtcgg      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc gtcctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taataattac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  425
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  425
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gaaacgatgg      300

ggtaaggatg gtccttactg gtacttcgat ctctggggcc gtggcaccct ggtcactgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgcc      420

atccagctga cccagagccc cagcagcctg agcgccagcg tgggcgacag agtgaccatc      480

acctgtcggg ccagccaggg catcagcagc gctctggcct ggtatcagca gaagcccggc      540

aaggccccca agctgctgat ctacgacgcg tcctccctgg aaagcggcgt gcccagcaga      600

ttcagcggca gcggctccgg caccgacttc accctgacca tcagcagcct gcagcccgag      660

gacttcgcca cctactactg ccagcagttt aataattacc ctctcacttt cggcggcgga      720

acaaaggtgg agatcaag                                                    738


<210>  426
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  426
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gaaaagaaga      300

gacagttatg gtccttactg gtacttcgat ctctggggcc gtggcaccct ggtcactgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgcc      420

atccagctga cccagagccc cagcagcctg agcgccagcg tgggcgacag agtgaccatc      480

acctgtcggg ccagccaggg catcagcagc gctctggcct ggtatcagca gaagcccggc      540

aaggccccca agctgctgat ctacgacgcg tcctccctgg aaagcggcgt gcccagcaga      600

ttcagcggca gcggctccgg caccgacttc accctgacca tcagcagcct gcagcccgag      660

gacttcgcca cctactactg ccagcagttt aataattacc ctctcacttt cggcggcgga      720

acaaaggtgg agatcaag                                                    738


<210>  427
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  427
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gaagaatcgt      300

cccccgcccg ggtactggta cttcgatctc tggggccgtg gcaccctggt cactgtgtcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgccatc      420

cagctgaccc agagccccag cagcctgagc gccagcgtgg gcgacagagt gaccatcacc      480

tgtcgggcca gccagggcat cagcagcgct ctggcctggt atcagcagaa gcccggcaag      540

gcccccaagc tgctgatcta cgacgcgtcc tccctggaaa gcggcgtgcc cagcagattc      600

agcggcagcg gctccggcac cgacttcacc ctgaccatca gcagcctgca gcccgaggac      660

ttcgccacct actactgcca gcagtttaat aattaccctc tcactttcgg cggcggaaca      720

aaggtggaga tcaag                                                       735


<210>  428
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain

<400>  428
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactcgaatg ggtgtccgcc atcagcggca gcggcggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtat attactgtgc gaagggaaga      300

cgatttagct ggtacttcga tctctggggc cgtggcaccc tggtcactgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcgc catccagctg      420

acccagagcc ccagcagcct gagcgccagc gtgggcgaca gagtgaccat cacctgtcgg      480

gccagccagg gcatcagcag cgctctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc gtcctccctg gaaagcggcg tgcccagcag attcagcggc      600

agcggctccg gcaccgactt caccctgacc atcagcagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagtt taataattac cctctcactt tcggcggcgg aacaaaggtg      720

gagatcaag                                                              729


<210>  429
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  429

Asn Ala Trp Met Ser 
1               5   


<210>  430
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  430

Ser Tyr Ala Met His 
1               5   


<210>  431
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  431

Ser Gly Gly Tyr Ser Trp Ser 
1               5           


<210>  432
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  432

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  433
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  433

Ser Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  434
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  434

Ser Tyr Ser Met Asn 
1               5   


<210>  435
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  435

Ser Tyr Tyr Trp Ser 
1               5   


<210>  436
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  436

Asp Tyr Gly Met Ser 
1               5   


<210>  437
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  437

Ser Tyr Asp Ile Asn 
1               5   


<210>  438
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  438

Ser Gly Asp Tyr Tyr Trp Ser 
1               5           


<210>  439
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  439

Asp Tyr Tyr Met Ser 
1               5   


<210>  440
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  440

Ser Ser Asn Trp Trp Ser 
1               5       


<210>  441
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  441

Ser Tyr Gly Ile Ser 
1               5   


<210>  442
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  442

Ser Asn Tyr Met Ser 
1               5   


<210>  443
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  443

Ser Tyr Gly Met His 
1               5   


<210>  444
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  444

Asp Tyr Thr Met His 
1               5   


<210>  445
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  445

Ser Tyr Ala Met Asn 
1               5   


<210>  446
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  446

Ser Gly Ser Tyr Tyr Trp Ser 
1               5           


<210>  447
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  447

Ser Tyr Ala Met Ser 
1               5   


<210>  448
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  448

Gly Tyr Thr Met Asn 
1               5   


<210>  449
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR1

<400>  449

Ser Tyr Trp Met His 
1               5   


<210>  450
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  450

Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  451
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  451

Ala Ile Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Ala Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  452
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  452

Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  453
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  453

Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  454
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  454

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  455
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  455

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  456
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  456

Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  457
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  457

Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  458
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  458

Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  459
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  459

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  460
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  460

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  461
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  461

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  462
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  462

Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  463
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  463

Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  464
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  464

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  465
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  465

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  466
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  466

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  467
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  467

Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  468
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  468

Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  469
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  469

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  470
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR2

<400>  470

Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  471
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  471

Asp Leu Pro Lys Leu Arg Asn Phe His Ile 
1               5                   10  


<210>  472
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  472

Leu Glu Tyr His Gly Phe Arg Gln Tyr Gly Leu Arg Tyr Trp His 
1               5                   10                  15  


<210>  473
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  473

Ile Lys Phe Trp Phe Ala Gly Ile Asn Tyr Phe Phe Pro 
1               5                   10              


<210>  474
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  474

Gly Phe Leu Gly Met Gly Ser Asn Phe Ile 
1               5                   10  


<210>  475
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  475

Gly Asp Arg Ala Arg Tyr Phe Asp Leu 
1               5                   


<210>  476
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  476

Tyr Pro Arg Gly Tyr His Gln Met Val Asp Ala Phe Asp Ile 
1               5                   10                  


<210>  477
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  477

Val Arg Phe Leu Ala Ala Arg Thr Thr Ile Pro Glu Ala Asn Phe Leu 
1               5                   10                  15      


<210>  478
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  478

Val Leu Ser Arg Ala Arg Phe Asp Tyr 
1               5                   


<210>  479
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  479

Leu Arg Gly Arg Val Phe Asp Pro 
1               5               


<210>  480
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  480

Ile Lys Phe Thr Ser Phe Leu Tyr Val His Gly Phe Leu 
1               5                   10              


<210>  481
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  481

Gly Gln Arg Trp Leu Tyr Leu Gly Gly Ile Arg Arg His 
1               5                   10              


<210>  482
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  482

Glu Trp Ile Pro Ser Arg Pro Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  483
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  483

Glu Ser Thr Gly Thr Gly Ala Phe Asp Ile 
1               5                   10  


<210>  484
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  484

Glu Arg Tyr Arg Arg Val Leu His Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  485
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  485

Glu Pro Asp Ala Phe Asp Ile 
1               5           


<210>  486
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  486

Glu His Met Gly Thr Ile Pro Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  487
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  487

Glu Glu Phe Gly Tyr Gly Asp Val Leu Tyr 
1               5                   10  


<210>  488
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  488

Glu Asp Val Val Lys Gly Ala Phe Asp Ile 
1               5                   10  


<210>  489
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  489

Glu Asp Phe Ser His Lys Leu Gly Tyr Phe Gln His 
1               5                   10          


<210>  490
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  490

Asp Tyr Asp Tyr Val 
1               5   


<210>  491
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  491

Asp Arg Arg Asp Trp Asp Trp Phe Asp Pro 
1               5                   10  


<210>  492
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  492

Asp Gln Gln Ala Leu Lys Tyr Arg Val Asp 
1               5                   10  


<210>  493
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  493

Asp Leu Thr Leu Gly Cys Phe Asp Tyr 
1               5                   


<210>  494
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  494

Asp Gly Ser Asn Ser Trp Tyr Phe Asp Leu 
1               5                   10  


<210>  495
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  495

Ala Phe Leu Phe Leu Ser Phe Ser Val 
1               5                   


<210>  496
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  496

Gly Ile Phe Tyr Ser Ser Lys Glu Asp Phe Asp Tyr 
1               5                   10          


<210>  497
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  497

Asp Ile Trp Ile Phe Tyr Ser Ser Asn Pro Lys Pro Thr Val Tyr 
1               5                   10                  15  


<210>  498
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  498

Lys Asp Gln Thr Leu Thr Tyr Gly Asn Trp Phe Asp Pro 
1               5                   10              


<210>  499
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  499

Asp His Tyr Glu Arg Gly Leu Tyr 
1               5               


<210>  500
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  500

Tyr Met Tyr Asn Trp Tyr Phe Asp Leu 
1               5                   


<210>  501
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  501

Asp Arg Arg Pro Ala Phe Asp Ile 
1               5               


<210>  502
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  502

His Leu Lys Arg Arg Pro Tyr Phe Asp Tyr 
1               5                   10  


<210>  503
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  503

Val His Lys Lys Pro Ile Phe Asp Tyr 
1               5                   


<210>  504
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  504

Thr Ser Arg Arg Cys Thr Phe Gln His 
1               5                   


<210>  505
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  505

Thr Ser Pro Arg Pro Leu Phe Gln His 
1               5                   


<210>  506
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  506

Pro Tyr Gln Val Arg Gly Val Tyr Phe Asp Tyr 
1               5                   10      


<210>  507
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  507

Pro Tyr Lys Lys Arg Arg Thr Val Phe Asp Tyr 
1               5                   10      


<210>  508
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  508

Leu Gln Arg Gly Leu Ala Leu Phe Gln His 
1               5                   10  


<210>  509
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  509

Ile Leu Ser Val Pro Tyr Phe Asp Leu 
1               5                   


<210>  510
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  510

Gly Trp Ile Arg Val Pro Leu Arg Leu Pro Leu Phe Gln His 
1               5                   10                  


<210>  511
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  511

Val Thr Ile Phe Ala Ile Phe Asp Ile 
1               5                   


<210>  512
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  512

Val Gly Arg Gly Phe Val His Phe Asp Leu 
1               5                   10  


<210>  513
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  513

Thr Ser Arg Gly Leu Cys Val Leu Phe Asp Tyr 
1               5                   10      


<210>  514
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  514

Ser Gly Pro Ser Ser Tyr Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  515
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  515

Asn Ile Tyr Met Gly Gly Ile Trp Phe Asp Pro 
1               5                   10      


<210>  516
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  516

Leu Thr Val Arg Thr Gly Ala Phe Asp Ile 
1               5                   10  


<210>  517
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  517

Leu Arg Thr Ala His Leu Asp Phe Asp Leu 
1               5                   10  


<210>  518
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  518

Asp Leu Ile Phe Pro Val Val Phe Asp Tyr 
1               5                   10  


<210>  519
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  519

Asp Gly Tyr Arg Lys Tyr Gly Tyr Val Phe Phe Asp Ile 
1               5                   10              


<210>  520
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  520

Asp Gly Arg Tyr Arg Arg Phe Trp His Ala Phe Asp Ile 
1               5                   10              


<210>  521
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  521

Ala His Ile Arg Gly Tyr Phe Asp Leu 
1               5                   


<210>  522
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  522

Trp Met Gly Gly Gly Gly Arg Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  523
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  523

Thr Ser Arg Thr Thr Trp Tyr Phe Asp Leu 
1               5                   10  


<210>  524
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  524

Trp Met Gly Gly Gly Gly Arg Leu Tyr Phe Asp Leu 
1               5                   10          


<210>  525
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  525

Trp Gly Gly Arg Leu Tyr Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  526
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  526

Val Ile Arg Gln Leu Trp Tyr Phe Asp Leu 
1               5                   10  


<210>  527
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  527

Val Phe Ala Asn Ser Trp Tyr Phe Asp Leu 
1               5                   10  


<210>  528
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  528

Val Asp Arg Thr Thr Trp Tyr Phe Asp Leu 
1               5                   10  


<210>  529
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  529

Arg Trp Gly Lys Asp Gly Pro Tyr Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  530
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  530

Arg Arg Asp Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  531
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  531

Asn Arg Pro Pro Pro Gly Tyr Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  532
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  532

Gly Arg Arg Phe Ser Trp Tyr Phe Asp Leu 
1               5                   10  


<210>  533
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  533

Cys Ala Arg Glu Asp Val Val Lys Gly Ala Phe Asp Ile Trp 
1               5                   10                  


<210>  534
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain HC CDR3

<400>  534

Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr 
1               5                   10  


<210>  535
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR1

<400>  535

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  536
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR1

<400>  536

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  537
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR1

<400>  537

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  538
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR1

<400>  538

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  539
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR2

<400>  539

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  540
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR2

<400>  540

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  541
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR2

<400>  541

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  542
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR3

<400>  542

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  543
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR3

<400>  543

Gln Gln Ala Asn Ser Phe Pro Leu Thr 
1               5                   


<210>  544
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR3

<400>  544

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  545
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSLN scFv domain LC CDR3

<400>  545

Gln Gln Trp Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  546
<211>  4
<212>  PRT
<213>  Unknown

<220>  
<223>  immunoreceptor tyrosine-based activation motif


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Xaa is Leu or Ile

<400>  546

Tyr Xaa Xaa Xaa 
1               


<210>  547
<211>  6
<212>  PRT
<213>  Unknown

<220>  
<223>  immunoreceptor tyrosine-based activation motif


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Xaa is Ser, Ile, Val or Leu

<220>
<221>  SITE
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  SITE
<222>  (4)..(5)
<223>  Xaa is any amino acid

<220>
<221>  SITE
<222>  (6)..(6)
<223>  Xaa is Ile, Val or Leu

<400>  547

Xaa Xaa Tyr Xaa Xaa Xaa 
1               5       


<210>  548
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  548
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agtagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

cggacgtccg gtggaggcac caagctggaa atcaaaggcg gaggtggaag cggaggggga      360

ggatctggcg gcggaggaag cggaggccag gtccagctgc agcagtctgg acctgagctg      420

gtgaagcctg gggcttcagt gaggatatcc tgcaaggctt ctggctacac cttcacaagt      480

taccatatac attgggtgaa gcagaggcct ggacagggac ttgagtggat tggatggatt      540

tatcctggaa atgttaatac tgagtacaat gagaagttca agggcaaggc cacactgact      600

gcagacaaat cgtccagcac agcctacatg cacctcagca gcctgacctc tgaggactct      660

gcggtctatt tctgtgccag agaggagatt acctatgcta tggactactg gggtcaagga      720

acctcagtca ccgtgtcctc a                                                741


<210>  549
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  549
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat tgtattgacc      420

cagagcccag gcaccctgag cctctctcca ggagagcggg ccaccctcag ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtcaagccc caagattgct catctacaaa gtctctaaca gatttagtgg tattccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca cgatctccag gctcgagcca      660

gaagatttcg ccgtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  550
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  550
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tgtaatgacc      420

cagaccccac tcagcctgcc cgtcactcca ggagagccgg ccagcatcag ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatct gcagaaacca      540

ggtcaatccc cacaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca agatctccag ggtcgaggca      660

gaagatgtcg gcgtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  551
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  551
gaggtgcagc tggtggagtc tgggggtggg ctggtgaagc ctgggggctc actgaggctt       60

tcctgcgcgg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggaaaag ggcttgagtg ggtgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcag attcaccatt agcagggacg attccaagaa cacactctac      240

ctgcagatga acagcctgaa aactgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tcaaatgacc      420

cagagcccat ccagcctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccaagc      600

aggttcagcg gttccggaag tggtactgat ttcaccctca cgatctcctc tctccagcca      660

gaagatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  552
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  552
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggacg aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagcc      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa a                                                741


<210>  553
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  553
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tgcattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatac atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccctt accgcggaca aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt atttctgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacgt tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagctcc      480

agtcagagta ttgtacacag taatgggaac acctatatgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgtcatcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa a                                                741


<210>  554
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  554
caggtgcagc tgcagcagtc tgggcctgag ctggtgaagc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggata caccttcact agctatcata tccagtgggt gaagcagagg      120

cctggacaag ggcttgagtg gatcggatgg atctaccctg gcgatggtag tacacagtat      180

aatgagaagt tcaagggcaa aaccaccctt accgcggaca aatcctccag cacagcctac      240

atgttgctga gcagcctgac ctctgaagac tctgctatct atttctgtgc gagggagggg      300

acctactacg ctatggacta ctggggccag ggaacctcag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgatgt tttgatgacc      420

cagactccac tctccctgcc tgtctctctt ggagaccaag tctccatctc ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttag aatggtatct gcagaaacca      540

ggtcagtctc caaagttgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca agatctcgag agtggaggct      660

gaggatctgg gagtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtgga      720

ggtactaaac tggaaatcaa a                                                741


<210>  555
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  555
cagctgcagc tgcaggagtc tgggcccggg ctggtgaagc cttcggaaac gctgagcctc       60

acctgcacgg tttctggata caccttcacc agctatcata tccagtggat ccgacagccc      120

cctggaaaag ggcttgagtg gatcggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcag agccacgatt agcgtggaca catccaagaa ccaattctcc      240

ctgaacctgg acagcgtgag tgctgcggac acggccattt attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggcaaa gggagcacgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagagcccaa gctccctgag tgcgtccgtg ggcgaccgcg tgaccatcac ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggaaggccc cgaaactgct catctacaag gtgagcaacc ggttctccgg cgtccccagc      600

cgcttctcag ggtccggctc ggggacggat ttcaccttca cgattagcag cttgcagccc      660

gaagacatcg ccacgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggccg      720

ggcacgaaag tggatattaa g                                                741


<210>  556
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  556
gaggtgcagc tggtgcagtc tggggccgag ctgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tccagtgggt aaaacaggcc      120

cctggacaag ggcttgagtg gatcggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agccacgctt accgtggaca aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagagcccat ccaccctgag tgcgtccgtg ggcgaccgcg tgaccatcac ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggaaggccc cgaaactgct catctacaag gtgagcaacc ggttctccgg cgtccccagc      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagcag cttgcagccc      660

gatgacttcg ccacgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggcag      720

ggcacgaaag tggaagttaa g                                                741


<210>  557
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  557
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tccagtgggt acgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccacgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat cgtcctgacc      420

cagagcccag ggaccctgag tttgtccccg ggcgagcgcg cgaccctcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggcaggccc cgcgactgct catctacaag gtgagcaacc ggttctccgg catccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagccg cttggagccc      660

gaagacttcg ccgtgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  558
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  558
caggtgaccc tgaagcagtc tggggccgag gtgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcacgg cttctggata caccttcacc agctatcatg tcagctgggt acgacaggcc      120

cctggacaag ggcttgagtg gttgggaagg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agtcacgatt accgcggaca aatccatgga cacatccttc      240

atggagctga ccagcctgac atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacct ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat cgtcctgacc      420

cagagcccag ggaccctgag tttgtccccg ggcgagcgcg cgaccctcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg cgtggtacca gcagaagccc      540

gggcaggccc cgcgactgct catctccaag gtgagcaacc ggttctccgg cgtccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagccg cttggagccc      660

gaagacttcg ccgtgtacta ctgccaacag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  559
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HLA scFv binding domain

<400>  559
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctggggcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tgcactgggt acgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agtcacgatt acccgggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat cgtcatgacc      420

cagaccccac tgtccctgcc tgtgaccccg ggcgagcccg cgagcatcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg actggtacct gcagaagccc      540

gggcagtccc cgcaactgct catctacaag gtgagcaacc ggttctccgg cgtccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca agattagccg cgtggaggcc      660

gaagacgtcg gcgtgtacta ctgcatgcag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  560
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  560

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  561
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  561

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  562
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  562

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  563
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  563

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp 
        35                  40                  45              


Leu Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  564
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  564

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  565
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  565

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  566
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  566

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  567
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  567

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  568
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  568

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  569
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-B*07 antigen binding domain

<400>  569

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp 
        35                  40                  45              


Leu Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  570
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  570

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ser Phe Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  571
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  571

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Arg Ser Ile Ser Pro Tyr Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  572
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  572

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ser Val Ile Trp Tyr Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln 
                165                 170                 175     


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg 
            180                 185                 190         


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
        195                 200                 205             


Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu 
                245         


<210>  573
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  573

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Glu Ile Leu Pro Arg Leu Ser Tyr Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  574
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  574

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Phe Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala His Ser Ser Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  575
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  575

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Ile Lys Ile Leu Pro Arg Leu Gly Tyr Tyr Tyr 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250     


<210>  576
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  576

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Thr Val Ile His Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  577
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  577

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Ile Val Glu Val Phe Leu Ser Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  578
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  578

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ile Phe Ile His Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  579
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  579

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Thr Phe Tyr Ser Tyr Ser Pro Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  580
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  580

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Trp Ile Lys Ile Leu Pro Arg Leu Gly Tyr Tyr Tyr 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250     


<210>  581
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  581

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Ser Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  582
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  582

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Lys Ile Leu Ala Pro Asn Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  583
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  583

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Lys Ser Trp Lys Tyr Phe Tyr Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  584
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  584

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Asn Thr Ser Thr Ile Pro Tyr Tyr Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  585
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  585

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Asp Val Asp Lys Asn Thr Ser Thr Ile Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  586
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  586

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Asp Ile Val Ser Ser Ser Ala Ile Tyr Trp Tyr 
            100                 105                 110         


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala 
    130                 135                 140                 


Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  587
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  587

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Ile Leu Pro Pro Tyr Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  588
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  588

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Thr Trp Ile Lys Ile Leu Pro Arg Tyr Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  589
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  589

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Ser Arg Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  590
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  590

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Val Leu Cys Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu 
                165                 170                 175     


Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  591
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  591

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Lys Ile Leu Pro Arg Pro Tyr Tyr Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  592
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  592

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Asn Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala 
    130                 135                 140                 


Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser 
145                 150                 155                 160 


Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  593
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  593

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Phe Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  594
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  594

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Glu Ile Val Glu Val Phe Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  595
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  595

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Asp Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  596
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  596

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Trp Ser Thr Asn Ile Leu Leu Ser Tyr Thr Lys Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  597
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  597

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Lys Thr Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  598
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  598

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Lys Tyr Phe His Asp Lys Tyr Phe His Asp Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  599
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  599

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Thr Ser Val Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  600
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  600

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Lys Ile Leu Pro Tyr Tyr Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  601
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  601

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Gln Trp Ile Tyr Ile Tyr Ile Asn Pro Arg Gly Phe Ile Phe 
            100                 105                 110         


Leu His Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
145                 150                 155                 160 


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
                165                 170                 175     


Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
            180                 185                 190         


Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
    210                 215                 220                 


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
225                 230                 235                 240 


Asp Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
                245                 250                 255     


Leu 
    


<210>  602
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  602

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Glu Asp Val Asp Phe His His Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  603
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  603

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Gly Val Asp Lys Asn Thr Ser Thr Ile Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  604
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  604

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys 
                165                 170                 175     


Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  605
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  605

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Ile His Val Asp Ile Arg Ser Met Glu Asp Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  606
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  606

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ile Gly Thr Ser Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  607
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  607

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Val Val Glu Val Phe Leu Tyr Tyr Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  608
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  608

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Tyr Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  609
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  609

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Trp Lys Tyr Phe Tyr Pro Arg Gly Ser Ile Phe 
            100                 105                 110         


Ile His Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
145                 150                 155                 160 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
                165                 170                 175     


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            180                 185                 190         


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
225                 230                 235                 240 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250                 255     


<210>  610
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  610

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Ile Val Glu Val Phe Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  611
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  611

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Lys Tyr Phe His Asp Trp Leu Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  612
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  612

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Val Asp Lys Asn Thr Ser Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  613
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  613

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gln Asn Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala 
    130                 135                 140                 


Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser 
145                 150                 155                 160 


Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  614
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-C*07 antigen binding domain

<400>  614

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
145                 150                 155                 160 


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn 
    210                 215                 220                 


Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  615
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  615

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Val Ser Gln Arg Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  616
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  616

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Asp Lys Asp Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  617
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  617

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Phe Tyr Cys Thr Asn Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  618
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  618

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Ser Ser Ser Gly Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  619
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  619

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gly Tyr Lys Tyr Asn Leu Tyr Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  620
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  620

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Leu Ser His Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr 
    130                 135                 140                 


Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
145                 150                 155                 160 


Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr Ser Thr 
            180                 185                 190         


Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
        195                 200                 205             


Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
    210                 215                 220                 


Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  621
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  621

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Arg Arg Tyr Asn Ser Cys Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  622
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  622

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Leu Ser His Tyr Tyr Tyr Tyr Leu Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr 
    130                 135                 140                 


Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
145                 150                 155                 160 


Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr Ser Thr 
            180                 185                 190         


Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
        195                 200                 205             


Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
    210                 215                 220                 


Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  623
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  623

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Thr Leu Leu Ser Leu Ser Tyr Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  624
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  624

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Leu Ser His Tyr Tyr Tyr Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr Gln 
    130                 135                 140                 


Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
145                 150                 155                 160 


Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr Ser Thr Ser 
            180                 185                 190         


Asn Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
        195                 200                 205             


Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
    210                 215                 220                 


Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  625
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  625

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Asp Arg Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  626
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  626

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Pro Pro Ser Leu Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Ser Ala Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr 
145                 150                 155                 160 


Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu 
                245         


<210>  627
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  627

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ala Tyr Cys Leu Ser Asp Ser Tyr Trp Tyr Phe Asp 
            100                 105                 110         


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Ser Val 
    130                 135                 140                 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
145                 150                 155                 160 


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
            180                 185                 190         


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  628
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*03 scFv

<400>  628

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Trp Lys Tyr Phe Tyr Pro Arg Gly Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  629
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*01 scFv

<400>  629

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Thr Ala Trp Tyr Tyr Tyr Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr Gln 
    130                 135                 140                 


Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
145                 150                 155                 160 


Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr Ser Thr Ser 
            180                 185                 190         


Asn Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
        195                 200                 205             


Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
    210                 215                 220                 


Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  630
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*01 scFv

<400>  630

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Lys Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gln Ser Val Leu Thr Gln Pro Pro Ser Ala 
    130                 135                 140                 


Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly 
                165                 170                 175     


Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
        195                 200                 205             


Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Trp Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  631
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*01 scFv

<400>  631

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gln Val Asp Lys Asn Thr Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  632
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*01 scFv

<400>  632

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Cys Gln Leu Ala Glu Tyr Phe Gln His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  633
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*01 scFv

<400>  633

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Val Asp Lys Asn Thr Ser Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  634
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*01 scFv

<400>  634

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Val Gln Leu Lys Leu Val His Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  635
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*01 scFv

<400>  635

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asp Tyr Val Thr Val Phe Tyr Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  636
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*01 scFv

<400>  636

Gln Leu Gln Leu Gln Glu Ser Gly Ser Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Ser Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Tyr Pro Ser Phe Tyr Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  637
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A*01 scFv

<400>  637

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Ser Asn Met Trp Ser Tyr Ser Leu Asn Asp Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  638
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L1

<400>  638

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  639
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L1

<400>  639

Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  640
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L1

<400>  640

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  641
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L1

<400>  641

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  642
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L1

<400>  642

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  643
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L1

<400>  643

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  644
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L1

<400>  644

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  645
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L2

<400>  645

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  646
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L2

<400>  646

Ser Thr Ser Asn Lys His Ser 
1               5           


<210>  647
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L2

<400>  647

Glu Val Ser Lys Arg Pro Ser 
1               5           


<210>  648
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L2

<400>  648

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  649
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L2

<400>  649

Ala Ala Thr Tyr Leu Pro Asp 
1               5           


<210>  650
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L3

<400>  650

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  651
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L3

<400>  651

Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val 
1               5                   10  


<210>  652
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L3

<400>  652

Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val 
1               5                   10  


<210>  653
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L3

<400>  653

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  654
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L3

<400>  654

Gln His Phe Trp Val Thr Pro Tyr Thr 
1               5                   


<210>  655
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L3

<400>  655

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  656
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-L3

<400>  656

Gln Gln Ala Asn Ser Phe Pro Leu Thr 
1               5                   


<210>  657
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  657

Ser Tyr Gly Ile Ser 
1               5   


<210>  658
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  658

Ser Tyr Ser Met Asn 
1               5   


<210>  659
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  659

Ser Gly Ser Tyr Tyr Trp Ser 
1               5           


<210>  660
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  660

Ser Tyr Tyr Trp Ser 
1               5   


<210>  661
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  661

Ser Tyr Trp Ile Gly 
1               5   


<210>  662
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  662

Ser Asn Tyr Met Ser 
1               5   


<210>  663
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  663

Ser Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  664
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  664

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  665
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  665

Ser Gly Tyr Ser Trp His 
1               5       


<210>  666
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  666

Thr Ser Gly Val Gly Val Gly 
1               5           


<210>  667
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  667

Ser Tyr Trp Met His 
1               5   


<210>  668
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  668

Ser Tyr Ala Met Ser 
1               5   


<210>  669
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  669

Ser Tyr Ala Met Asn 
1               5   


<210>  670
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  670

Asp Tyr Tyr Met Ser 
1               5   


<210>  671
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  671

Ser Asn Ser Ala Ala Trp Asn 
1               5           


<210>  672
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  672

Asp Tyr Tyr Met His 
1               5   


<210>  673
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  673

Ser Ser Asn Trp Trp Gly 
1               5       


<210>  674
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  674

Ser Tyr Asp Ile Asn 
1               5   


<210>  675
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H1

<400>  675

Ser Gly Gly Tyr Ser Trp Ser 
1               5           


<210>  676
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  676

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  677
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  677

Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  678
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  678

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  679
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  679

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  680
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  680

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  681
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  681

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  682
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  682

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  683
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  683

Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  684
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  684

Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  685
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  685

Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  686
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  686

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  687
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  687

Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  688
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  688

Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  689
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  689

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  690
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  690

Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  691
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  691

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  692
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H2

<400>  692

Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  693
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  693

Glu Arg Val Ser Gln Arg Gly Ala Phe Asp Ile 
1               5                   10      


<210>  694
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  694

Gly Asn Pro Asp Lys Asp Pro Phe Asp Tyr 
1               5                   10  


<210>  695
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  695

Asp Phe Tyr Cys Thr Asn Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  696
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  696

Glu Ser Ser Ser Gly Ser Tyr Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  697
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  697

Asp Ser Gly Tyr Lys Tyr Asn Leu Tyr Tyr Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  698
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  698

Gly Gly Asp Leu Ser His Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10              


<210>  699
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  699

Glu Asn Arg Arg Tyr Asn Ser Cys Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  700
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  700

Gly Gly Asp Leu Ser His Tyr Tyr Tyr Tyr Leu Asp Val 
1               5                   10              


<210>  701
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  701

Ala Thr Leu Leu Ser Leu Ser Tyr Asp Ala Phe Asp Ile 
1               5                   10              


<210>  702
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  702

Gly Gly Asp Leu Ser His Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  703
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  703

Glu Arg Asp Arg Trp Phe Asp Pro 
1               5               


<210>  704
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  704

Glu Thr Pro Pro Ser Leu Gly Ala Phe Asp Ile 
1               5                   10      


<210>  705
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  705

Glu Ala Tyr Cys Leu Ser Asp Ser Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  706
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  706

Glu Ser Trp Lys Tyr Phe Tyr Pro Arg Gly Tyr Met Asp Val 
1               5                   10                  


<210>  707
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  707

Gly Gly Val Val Ser His Tyr Ala Met Asp Cys 
1               5                   10      


<210>  708
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  708

Ser Phe Asp Trp Phe Asp Pro 
1               5           


<210>  709
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  709

Glu Arg Ser Ile Ser Pro Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  710
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  710

Asp Ser Val Ile Trp Tyr Trp Phe Asp Pro 
1               5                   10  


<210>  711
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  711

Glu Glu Ile Leu Pro Arg Leu Ser Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  712
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  712

Gly Gly Arg Ala His Ser Ser Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  713
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  713

Asp Arg Ile Lys Ile Leu Pro Arg Leu Gly Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  714
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  714

Asp Thr Val Ile His Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  715
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  715

Asp Val Ile Val Glu Val Phe Leu Ser Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  716
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  716

Asp Ile Phe Ile His Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  717
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  717

Asp Gly Thr Phe Tyr Ser Tyr Ser Pro Tyr Tyr Phe Asp Tyr 
1               5                   10                  


<210>  718
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  718

Glu Trp Ile Lys Ile Leu Pro Arg Leu Gly Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  719
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  719

Asp Arg Ser Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  720
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  720

Asp Lys Ile Leu Ala Pro Asn Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  721
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  721

Glu Lys Ser Trp Lys Tyr Phe Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  722
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  722

Glu Asn Thr Ser Thr Ile Pro Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  723
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  723

Glu Asp Val Asp Lys Asn Thr Ser Thr Ile Tyr Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  724
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  724

Asp Gly Gly Asp Ile Val Ser Ser Ser Ala Ile Tyr Trp Tyr Phe Asp 
1               5                   10                  15      


Leu 
    


<210>  725
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  725

Asp Leu Ile Leu Pro Pro Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  726
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  726

Glu Thr Trp Ile Lys Ile Leu Pro Arg Tyr Tyr Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  727
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  727

Asp Leu Ser Arg Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  728
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  728

Glu His Ile Val Leu Cys Phe Asp Tyr 
1               5                   


<210>  729
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  729

Asp Lys Ile Leu Pro Arg Pro Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  730
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  730

Gly Ser Asn Glu Tyr Phe Gln His 
1               5               


<210>  731
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  731

Gly Thr Ser Tyr Trp Tyr Phe Asp Leu 
1               5                   


<210>  732
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  732

Glu Glu Ile Val Glu Val Phe Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  733
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  733

Val Asp Asp Tyr Tyr Phe Asp Tyr 
1               5               


<210>  734
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  734

Ser Thr Asn Ile Leu Leu Ser Tyr Thr Lys Ala Phe Asp Ile 
1               5                   10                  


<210>  735
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  735

Asp Lys Thr Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  736
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  736

Glu Lys Tyr Phe His Asp Lys Tyr Phe His Asp Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  737
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  737

Asp Thr Ser Val Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  738
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  738

Glu Lys Ile Leu Pro Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  739
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  739

Gln Trp Ile Tyr Ile Tyr Ile Asn Pro Arg Gly Phe Ile Phe Leu His 
1               5                   10                  15      


Asp Ala Phe Asp Ile 
            20      


<210>  740
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  740

Glu Asp Val Asp Phe His His Asp Ala Phe Asp Ile 
1               5                   10          


<210>  741
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  741

Glu Gly Val Asp Lys Asn Thr Ser Thr Ile Tyr Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  742
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  742

Asp Arg Arg Gly Tyr Phe Asp Leu 
1               5               


<210>  743
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  743

Gly Ile His Val Asp Ile Arg Ser Met Glu Asp Trp Phe Asp Pro 
1               5                   10                  15  


<210>  744
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  744

Asp Ile Gly Thr Ser Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  745
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  745

Glu Val Val Glu Val Phe Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  746
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  746

Asp Leu Tyr Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  747
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  747

Glu Ser Trp Lys Tyr Phe Tyr Pro Arg Gly Ser Ile Phe Ile His Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Met Asp Val 
            20          


<210>  748
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  748

Asp Arg Ile Val Glu Val Phe Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  749
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  749

Glu Lys Tyr Phe His Asp Trp Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  750
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  750

Asp Leu Val Asp Lys Asn Thr Ser Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  751
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  751

Val Gln Asn Glu Tyr Phe Gln His 
1               5               


<210>  752
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  752

Ala Asn Trp Phe Asp Pro 
1               5       


<210>  753
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  753

Gly Gly Trp Thr Ala Trp Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  754
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  754

Ala Lys Tyr Tyr Tyr Met Asp Val 
1               5               


<210>  755
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  755

Asp Gln Val Asp Lys Asn Thr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  756
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  756

Ala Cys Gln Leu Ala Glu Tyr Phe Gln His 
1               5                   10  


<210>  757
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  757

Asp Arg Val Asp Lys Asn Thr Ser Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  758
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  758

Arg Val Gln Leu Lys Leu Val His Trp Phe Asp Pro 
1               5                   10          


<210>  759
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  759

Tyr Tyr Asp Tyr Val Thr Val Phe Tyr Phe Gln His 
1               5                   10          


<210>  760
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  760

Glu Ser Tyr Pro Ser Phe Tyr Ala Phe Asp Ile 
1               5                   10      


<210>  761
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR-H3

<400>  761

Ser Asn Met Trp Ser Tyr Ser Leu Asn Asp Tyr Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  762
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  extracellular ligand binding domain VL

<400>  762

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  763
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  extracellular ligand binding domain VH

<400>  763

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  764
<211>  18
<212>  PRT
<213>  Unknown

<220>  
<223>  T2A self-cleaving peptide

<400>  764

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  765
<211>  19
<212>  PRT
<213>  Unknown

<220>  
<223>  P2A self-cleaving peptide

<400>  765

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  766
<211>  20
<212>  PRT
<213>  Unknown

<220>  
<223>  E2A self-cleaving peptide

<400>  766

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  767
<211>  22
<212>  PRT
<213>  Unknown

<220>  
<223>  F2A self-cleaving peptide

<400>  767

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  768
<211>  63
<212>  DNA
<213>  Unknown

<220>  
<223>  encodes T2A self-cleaving peptide

<400>  768
ggatccggag agggcagagg cagcctgctg acatgtggcg acgtggaaga gaaccctggc       60

ccc                                                                     63


<210>  769
<211>  943
<212>  RNA
<213>  Homo sapiens

<400>  769
auuccugaag cugacagcau ucgggccgag augucucgcu ccguggccuu agcugugcuc       60

gcgcuacucu cucuuucugg ccuggaggcu auccagcgua cuccaaagau ucagguuuac      120

ucacgucauc cagcagagaa uggaaaguca aauuuccuga auugcuaugu gucuggguuu      180

cauccauccg acauugaagu ugacuuacug aagaauggag agagaauuga aaaaguggag      240

cauucagacu ugucuuucag caaggacugg ucuuucuauc ucuuguacua cacugaauuc      300

acccccacug aaaaagauga guaugccugc cgugugaacc augugacuuu gucacagccc      360

aagauaguua agugggaucg agacauguaa gcagcaucau ggagguuuga agaugccgca      420

uuuggauugg augaauucca aauucugcuu gcuugcuuuu uaauauugau augcuuauac      480

acuuacacuu uaugcacaaa auguaggguu auaauaaugu uaacauggac augaucuucu      540

uuauaauucu acuuugagug cugucuccau guuugaugua ucugagcagg uugcuccaca      600

gguagcucua ggagggcugg caacuuagag guggggagca gagaauucuc uuauccaaca      660

ucaacaucuu ggucagauuu gaacucuuca aucucuugca cucaaagcuu guuaagauag      720

uuaagcgugc auaaguuaac uuccaauuua cauacucugc uuagaauuug ggggaaaauu      780

uagaaauaua auugacagga uuauuggaaa uuuguuauaa ugaaugaaac auuuugucau      840

auaagauuca uauuuacuuc uuauacauuu gauaaaguaa ggcaugguug ugguuaaucu      900

gguuuauuuu uguuccacaa guuaaauaaa ucauaaaacu uga                        943


<210>  770
<211>  6654
<212>  DNA
<213>  Homo sapiens

<400>  770
aagtggaggc gtcgcgctgg cgggcattcc tgaagctgac agcattcggg ccgagatgtc       60

tcgctccgtg gccttagctg tgctcgcgct actctctctt tctggcctgg aggctatcca      120

gcgtgagtct ctcctaccct cccgctctgg tccttcctct cccgctctgc accctctgtg      180

gccctcgctg tgctctctcg ctccgtgact tcccttctcc aagttctcct tggtggcccg      240

ccgtggggct agtccagggc tggatctcgg ggaagcggcg gggtggcctg ggagtgggga      300

agggggtgcg cacccgggac gcgcgctact tgcccctttc ggcggggagc aggggagacc      360

tttggcctac ggcgacggga gggtcgggac aaagtttagg gcgtcgataa gcgtcagagc      420

gccgaggttg ggggagggtt tctcttccgc tctttcgcgg ggcctctggc tcccccagcg      480

cagctggagt gggggacggg taggctcgtc ccaaaggcgc ggcgctgagg tttgtgaacg      540

cgtggagggg cgcttggggt ctgggggagg cgtcgcccgg gtaagcctgt ctgctgcggc      600

tctgcttccc ttagactgga gagctgtgga cttcgtctag gcgcccgcta agttcgcatg      660

tcctagcacc tctgggtcta tgtggggcca caccgtgggg aggaaacagc acgcgacgtt      720

tgtagaatgc ttggctgtga tacaaagcgg tttcgaataa ttaacttatt tgttcccatc      780

acatgtcact tttaaaaaat tataagaact acccgttatt gacatctttc tgtgtgccaa      840

ggactttatg tgctttgcgt catttaattt tgaaaacagt tatcttccgc catagataac      900

tactatggtt atcttctgcc tctcacagat gaagaaacta aggcaccgag attttaagaa      960

acttaattac acaggggata aatggcagca atcgagattg aagtcaagcc taaccagggc     1020

ttttgcggga gcgcatgcct tttggctgta attcgtgcat ttttttttaa gaaaaacgcc     1080

tgccttctgc gtgagattct ccagagcaaa ctgggcggca tgggccctgt ggtcttttcg     1140

tacagagggc ttcctctttg gctctttgcc tggttgtttc caagatgtac tgtgcctctt     1200

actttcggtt ttgaaaacat gagggggttg ggcgtggtag cttacgcctg taatcccagc     1260

acttagggag gccgaggcgg gaggatggct tgaggtccgt agttgagacc agcctggcca     1320

acatggtgaa gcctggtctc tacaaaaaat aataacaaaa attagccggg tgtggtggct     1380

cgtgcctgtg gtcccagctg ctccggtggc tgaggcggga ggatctcttg agcttaggct     1440

tttgagctat catggcgcca gtgcactcca gcgtgggcaa cagagcgaga ccctgtctct     1500

caaaaaagaa aaaaaaaaaa aaagaaagag aaaagaaaag aaagaaagaa gtgaaggttt     1560

gtcagtcagg ggagctgtaa aaccattaat aaagataatc caagatggtt accaagactg     1620

ttgaggacgc cagagatctt gagcactttc taagtacctg gcaatacact aagcgcgctc     1680

accttttcct ctggcaaaac atgatcgaaa gcagaatgtt ttgatcatga gaaaattgca     1740

tttaatttga atacaattta tttacaacat aaaggataat gtatatatca ccaccattac     1800

tggtatttgc tggttatgtt agatgtcatt ttaaaaaata acaatctgat atttaaaaaa     1860

aaatcttatt ttgaaaattt ccaaagtaat acatgccatg catagaccat ttctggaaga     1920

taccacaaga aacatgtaat gatgattgcc tctgaaggtc tattttcctc ctctgacctg     1980

tgtgtgggtt ttgtttttgt tttactgtgg gcataaatta atttttcagt taagttttgg     2040

aagcttaaat aactctccaa aagtcataaa gccagtaact ggttgagccc aaattcaaac     2100

ccagcctgtc tgatacttgt cctcttctta gaaaagatta cagtgatgct ctcacaaaat     2160

cttgccgcct tccctcaaac agagagttcc aggcaggatg aatctgtgct ctgatccctg     2220

aggcatttaa tatgttctta ttattagaag ctcagatgca aagagctctc ttagctttta     2280

atgttatgaa aaaaatcagg tcttcattag attccccaat ccacctcttg atggggctag     2340

tagcctttcc ttaatgatag ggtgtttcta gagagatata tctggtcaag gtggcctggt     2400

actcctcctt ctccccacag cctcccagac aaggaggagt agctgccttt tagtgatcat     2460

gtaccctgaa tataagtgta tttaaaagaa ttttatacac atatatttag tgtcaatctg     2520

tatatttagt agcactaaca cttctcttca ttttcaatga aaaatataga gtttataata     2580

ttttcttccc acttccccat ggatggtcta gtcatgcctc tcattttgga aagtactgtt     2640

tctgaaacat taggcaatat attcccaacc tggctagttt acagcaatca cctgtggatg     2700

ctaattaaaa cgcaaatccc actgtcacat gcattactcc atttgatcat aatggaaagt     2760

atgttctgtc ccatttgcca tagtcctcac ctatccctgt tgtattttat cgggtccaac     2820

tcaaccattt aaggtatttg ccagctcttg tatgcattta ggttttgttt ctttgttttt     2880

tagctcatga aattaggtac aaagtcagag aggggtctgg catataaaac ctcagcagaa     2940

ataaagaggt tttgttgttt ggtaagaaca taccttgggt tggttgggca cggtggctcg     3000

tgcctgtaat cccaacactt tgggaggcca aggcaggctg atcacttgaa gttgggagtt     3060

caagaccagc ctggccaaca tggtgaaatc ccgtctctac tgaaaataca aaaattaacc     3120

aggcatggtg gtgtgtgcct gtagtcccag gaatcacttg aacccaggag gcggaggttg     3180

cagtgagctg agatctcacc actgcacact gcactccagc ctgggcaatg gaatgagatt     3240

ccatcccaaa aaataaaaaa ataaaaaaat aaagaacata ccttgggttg atccacttag     3300

gaacctcaga taataacatc tgccacgtat agagcaattg ctatgtccca ggcactctac     3360

tagacacttc atacagttta gaaaatcaga tgggtgtaga tcaaggcagg agcaggaacc     3420

aaaaagaaag gcataaacat aagaaaaaaa atggaagggg tggaaacaga gtacaataac     3480

atgagtaatt tgatgggggc tattatgaac tgagaaatga actttgaaaa gtatcttggg     3540

gccaaatcat gtagactctt gagtgatgtg ttaaggaatg ctatgagtgc tgagagggca     3600

tcagaagtcc ttgagagcct ccagagaaag gctcttaaaa atgcagcgca atctccagtg     3660

acagaagata ctgctagaaa tctgctagaa aaaaaacaaa aaaggcatgt atagaggaat     3720

tatgagggaa agataccaag tcacggttta ttcttcaaaa tggaggtggc ttgttgggaa     3780

ggtggaagct catttggcca gagtggaaat ggaattggga gaaatcgatg accaaatgta     3840

aacacttggt gcctgatata gcttgacacc aagttagccc caagtgaaat accctggcaa     3900

tattaatgtg tcttttcccg atattcctca ggtactccaa agattcaggt ttactcacgt     3960

catccagcag agaatggaaa gtcaaatttc ctgaattgct atgtgtctgg gtttcatcca     4020

tccgacattg aagttgactt actgaagaat ggagagagaa ttgaaaaagt ggagcattca     4080

gacttgtctt tcagcaagga ctggtctttc tatctcttgt actacactga attcaccccc     4140

actgaaaaag atgagtatgc ctgccgtgtg aaccatgtga ctttgtcaca gcccaagata     4200

gttaagtggg gtaagtctta cattcttttg taagctgctg aaagttgtgt atgagtagtc     4260

atatcataaa gctgctttga tataaaaaag gtctatggcc atactaccct gaatgagtcc     4320

catcccatct gatataaaca atctgcatat tgggattgtc agggaatgtt cttaaagatc     4380

agattagtgg cacctgctga gatactgatg cacagcatgg tttctgaacc agtagtttcc     4440

ctgcagttga gcagggagca gcagcagcac ttgcacaaat acatatacac tcttaacact     4500

tcttacctac tggcttcctc tagcttttgt ggcagcttca ggtatattta gcactgaacg     4560

aacatctcaa gaaggtatag gcctttgttt gtaagtcctg ctgtcctagc atcctataat     4620

cctggacttc tccagtactt tctggctgga ttggtatctg aggctagtag gaagggcttg     4680

ttcctgctgg gtagctctaa acaatgtatt catgggtagg aacagcagcc tattctgcca     4740

gccttatttc taaccatttt agacatttgt tagtacatgg tattttaaaa gtaaaactta     4800

atgtcttcct tttttttctc cactgtcttt ttcatagatc gagacatgta agcagcatca     4860

tggaggtaag tttttgacct tgagaaaatg tttttgtttc actgtcctga ggactattta     4920

tagacagctc taacatgata accctcacta tgtggagaac attgacagag taacatttta     4980

gcagggaaag aagaatccta cagggtcatg ttcccttctc ctgtggagtg gcatgaagaa     5040

ggtgtatggc cccaggtatg gccatattac tgaccctcta cagagagggc aaaggaactg     5100

ccagtatggt attgcaggat aaaggcaggt ggttacccac attacctgca aggctttgat     5160

ctttcttctg ccatttccac attggacatc tctgctgagg agagaaaatg aaccactctt     5220

ttcctttgta taatgttgtt ttattcttca gacagaagag aggagttata cagctctgca     5280

gacatcccat tcctgtatgg ggactgtgtt tgcctcttag aggttcccag gccactagag     5340

gagataaagg gaaacagatt gttataactt gatataatga tactataata gatgtaacta     5400

caaggagctc cagaagcaag agagagggag gaacttggac ttctctgcat ctttagttgg     5460

agtccaaagg cttttcaatg aaattctact gcccagggta cattgatgct gaaaccccat     5520

tcaaatctcc tgttatattc tagaacaggg aattgatttg ggagagcatc aggaaggtgg     5580

atgatctgcc cagtcacact gttagtaaat tgtagagcca ggacctgaac tctaatatag     5640

tcatgtgtta cttaatgacg gggacatgtt ctgagaaatg cttacacaaa cctaggtgtt     5700

gtagcctact acacgcatag gctacatggt atagcctatt gctcctagac tacaaacctg     5760

tacagcctgt tactgtactg aatactgtgg gcagttgtaa cacaatggta agtatttgtg     5820

tatctaaaca tagaagttgc agtaaaaata tgctatttta atcttatgag accactgtca     5880

tatatacagt ccatcattga ccaaaacatc atatcagcat tttttcttct aagattttgg     5940

gagcaccaaa gggatacact aacaggatat actctttata atgggtttgg agaactgtct     6000

gcagctactt cttttaaaaa ggtgatctac acagtagaaa ttagacaagt ttggtaatga     6060

gatctgcaat ccaaataaaa taaattcatt gctaaccttt ttcttttctt ttcaggtttg     6120

aagatgccgc atttggattg gatgaattcc aaattctgct tgcttgcttt ttaatattga     6180

tatgcttata cacttacact ttatgcacaa aatgtagggt tataataatg ttaacatgga     6240

catgatcttc tttataattc tactttgagt gctgtctcca tgtttgatgt atctgagcag     6300

gttgctccac aggtagctct aggagggctg gcaacttaga ggtggggagc agagaattct     6360

cttatccaac atcaacatct tggtcagatt tgaactcttc aatctcttgc actcaaagct     6420

tgttaagata gttaagcgtg cataagttaa cttccaattt acatactctg cttagaattt     6480

gggggaaaat ttagaaatat aattgacagg attattggaa atttgttata atgaatgaaa     6540

cattttgtca tataagattc atatttactt cttatacatt tgataaagta aggcatggtt     6600

gtggttaatc tggtttattt ttgttccaca agttaaataa atcataaaac ttga           6654


<210>  771
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  encodes HLA-A*02:01:01:01

<400>  771
cagaagcaga ggggtcaggg cgaagtccca gggccccagg cgtggctctc agggtctcag       60

gccccgaagg cggtgtatgg attggggagt cccagccttg gggattcccc aactccgcag      120

tttcttttct ccctctccca acctatgtag ggtccttctt cctggatact cacgacgcgg      180

acccagttct cactcccatt gggtgtcggg tttccagaga agccaatcag tgtcgtcgcg      240

gtcgcggttc taaagtccgc acgcacccac cgggactcag attctcccca gacgccgagg      300

atggccgtca tggcgccccg aaccctcgtc ctgctactct cgggggctct ggccctgacc      360

cagacctggg cgggctctca ctccatgagg tatttcttca catccgtgtc ccggcccggc      420

cgcggggagc cccgcttcat cgcagtgggc tacgtggacg acacgcagtt cgtgcggttc      480

gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga gcaggagggt      540

ccggagtatt gggacgggga gacacggaaa gtgaaggccc actcacagac tcaccgagtg      600

gacctgggga ccctgcgcgg ctactacaac cagagcgagg ccggttctca caccgtccag      660

aggatgtatg gctgcgacgt ggggtcggac tggcgcttcc tccgcgggta ccaccagtac      720

gcctacgacg gcaaggatta catcgccctg aaagaggacc tgcgctcttg gaccgcggcg      780

gacatggcag ctcagaccac caagcacaag tgggaggcgg cccatgtggc ggagcagttg      840

agagcctacc tggagggcac gtgcgtggag tggctccgca gatacctgga gaacgggaag      900

gagacgctgc agcgcacgga cgcccccaaa acgcatatga ctcaccacgc tgtctctgac      960

catgaagcca ccctgaggtg ctgggccctg agcttctacc ctgcggagat cacactgacc     1020

tggcagcggg atggggagga ccagacccag gacacggagc tcgtggagac caggcctgca     1080

ggggatggaa ccttccagaa gtgggcggct gtggtggtgc cttctggaca ggagcagaga     1140

tacacctgcc atgtgcagca tgagggtttg cccaagcccc tcaccctgag atgggagccg     1200

tcttcccagc ccaccatccc catcgtgggc atcattgctg gcctggttct ctttggagct     1260

gtgatcactg gagctgtggt cgctgctgtg atgtggagga ggaagagctc agatagaaaa     1320

ggagggagct actctcaggc tgcaagcagt gacagtgccc agggctctga tgtgtctctc     1380

acagcttgta aagtgtgaga cagctgcctt gtgtgggact gagaggcaag agttgttcct     1440

gcccttccct ttgtgacttg aagaaccctg actttgtttc tgcaaaggca cctgcatgtg     1500

tctgtgttcg tgtaggcata atgtgaggag gtggggagac caccccaccc ccatgtccac     1560

catgaccctc ttcccacgct gacctgtgct ccctccccaa tcatctttcc tgttccagag     1620

aggtggggct gaggtgtctc catctctgtc tcaacttcat ggtgcactga gctgtaactt     1680

cttccttccc tattaaaa                                                   1698


<210>  772
<211>  3217
<212>  DNA
<213>  Homo sapiens

<400>  772
atggccgtca tggcgccccg aaccctcgtc ctgctactct cgggggctct ggccctgacc       60

cagacctggg cgggtgagtg cggggtcggg agggaaacgg cctctgtggg gagaagcaac      120

gggcccgcct ggcgggggcg caggacccgg gaagccgcgc cgggaggagg gtcgggcggg      180

tctcagccac tcctcgtccc caggctctca ctccatgagg tatttcttca catccgtgtc      240

ccggcccggc cgcggggagc cccgcttcat cgcagtgggc tacgtggacg acacgcagtt      300

cgtgcggttc gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga      360

gcaggagggt ccggagtatt gggacgggga gacacggaaa gtgaaggccc actcacagac      420

tcaccgagtg gacctgggga ccctgcgcgg ctactacaac cagagcgagg ccggtgagtg      480

accccggccc ggggcgcagg tcacgacctc tcatccccca cggacgggcc aggtcgccca      540

cagtctccgg gtccgagatc cgccccgaag ccgcgggacc ccgagaccct tgccccggga      600

gaggcccagg cgcctttacc cggtttcatt ttcagtttag gccaaaaatc cccccaggtt      660

ggtcggggcg gggcggggct cgggggaccg ggctgaccgc ggggtccggg ccaggttctc      720

acaccgtcca gaggatgtat ggctgcgacg tggggtcgga ctggcgcttc ctccgcgggt      780

accaccagta cgcctacgac ggcaaggatt acatcgccct gaaagaggac ctgcgctctt      840

tgaccgcggc ggacatggca gctcagacca ccaagcacaa gtgggaggcg gcccatgtgg      900

cggagcagtt gagagcctac ctggagggca cgtgcgtgga gtggctccgc agatacctgg      960

agaacgggaa ggagacgctg cagcgcacgg gtaccagggg ccacggggcg cctccctgat     1020

cgcctgtaga tctcccgggc tggcctccca caaggagggg agacaattgg gaccaacact     1080

agaatatcgc cctccctctg gtcctgaggg agaggaatcc tcctgggttt ccagatcctg     1140

taccagagag tgactctgag gttccgccct gctctctgac acaattaagg gataaaatct     1200

ctgaaggaat gacgggaaga cgatccctcg aatactgatg agtggttccc tttgacacac     1260

acaggcagca gccttgggcc cgtgactttt cctctcaggc cttgttctct gcttcacact     1320

caatgtgtgt gggggtctga gtccagcact tctgagtcct tcagcctcca ctcaggtcag     1380

gaccagaagt cgctgttccc tcttcaggga ctagaatttt ccacggaata ggagattatc     1440

ccaggtgcct gtgtccaggc tggtgtctgg gttctgtgct cccttcccca tcccaggtgt     1500

cctgtccatt ctcaagatag ccacatgtgt gctggaggag tgtcccatga cagatgcaaa     1560

atgcctgaat gatctgactc ttcctgacag acgcccccaa aacgcatatg actcaccacg     1620

ctgtctctga ccatgaagcc accctgaggt gctgggccct gagcttctac cctgcggaga     1680

tcacactgac ctggcagcgg gatggggagg accagaccca ggacacggag ctcgtggaga     1740

ccaggcctgc aggggatgga accttccaga agtgggcggc tgtggtggtg ccttctggac     1800

aggagcagag atacacctgc catgtgcagc atgagggttt gcccaagccc ctcaccctga     1860

gatggggtaa ggagggagac gggggtgtca tgtcttttag ggaaagcagg agcctctctg     1920

acctttagca gggtcagggc ccctcacctt cccctctttt cccagagccg tcttcccagc     1980

ccaccatccc catcgtgggc atcattgctg gcctggttct ctttggagct gtgatcactg     2040

gagctgtggt cgctgctgtg atgtggagga ggaagagctc aggtggggaa ggggtgaagg     2100

gtgggtctga gatttcttgt ctcactgagg gttccaagac ccaggtagaa gtgtgccctg     2160

cctcgttact gggaagcacc acccacaatt atgggcctac ccagcctggg ccctgtgtgc     2220

cagcacttac tcttttgtaa agcacctgtt aaaatgaagg acagatttat caccttgatt     2280

acagcggtga tgggacctga tcccagcagt cacaagtcac aggggaaggt ccctgaggac     2340

cttcaggagg gcggttggtc caggacccac acctgctttc ttcatgtttc ctgatcccgc     2400

cctgggtctg cagtcacaca tttctggaaa cttctctgag gtccaagact tggaggttcc     2460

tctaggacct taaggccctg actcctttct ggtatctcac aggacatttt cttcccacag     2520

atagaaaagg agggagctac tctcaggctg caagtaagta tgaaggaggc tgatgcctga     2580

ggtccttggg atattgtgtt tgggagccca tgggggagct cacccacccc acaattcctc     2640

ctctagccac atcttctgtg ggatctgacc aggttctgtt tttgttctac cccaggcagt     2700

gacagtgccc agggctctga tgtgtctctc acagcttgta aaggtgagag cctggagggc     2760

ctgatgtgtg ttgggtgttg ggcggaacag tggacacagc tgtgctatgg ggtttctttc     2820

cattggatgt attgagcatg cgatgggctg tttaaagtgt gacccctcac tgtgacagat     2880

acgaatttgt tcatgaatat ttttttctat agtgtgagac agctgccttg tgtgggactg     2940

agaggcaaga gttgttcctg cccttccctt tgtgacttga agaaccctga ctttgtttct     3000

gcaaaggcac ctgcatgtgt ctgtgttcgt gtaggcataa tgtgaggagg tggggagacc     3060

accccacccc catgtccacc atgaccctct tcccacgctg acctgtgctc cctccccaat     3120

catctttcct gttccagaga ggtggggctg aggtgtctcc atctctgtct caacttcatg     3180

gtgcactgag ctgtaacttc ttccttccct attaaaa                              3217


<210>  773
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  encodes scaffold sequence

<400>  773
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt ttt                                               83


<210>  774
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  774
tggacgacac gcagttcgtg                                                   20


<210>  775
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  775
cagatacctg gagaacggga                                                   20


<210>  776
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  776
tcccgttctc caggtatctg                                                   20


<210>  777
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  777
ccgccgcggt ccaagagcgc                                                   20


<210>  778
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  778
cctgcgctct tggaccgcgg                                                   20


<210>  779
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  779
ggacctgcgc tcttggaccg c                                                 21


<210>  780
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  780
aaggagacgc tgcagcgcac ggg                                               23


<210>  781
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  781
gaaggagacg ctgcagcgca cgg                                               23


<210>  782
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  782
gcgggcgccg tggatagagc agg                                               23


<210>  783
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  783
tgctctatcc acggcgcccg cgg                                               23


<210>  784
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  784
cgatgaagcg gggctccccg cgg                                               23


<210>  785
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  785
cgtgtcccgg cccggccgcg ggg                                               23


<210>  786
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  786
cggctccatc ctctggctcg cgg                                               23


<210>  787
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  787
gatgtaatcc ttgccgtcgt agg                                               23


<210>  788
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  788
acagcgacgc cgcgagccag agg                                               23


<210>  789
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  789
ggatggagcc gcgggcgccg tgg                                               23


<210>  790
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  790
ggcgccgtgg atagagcagg agg                                               23


<210>  791
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  791
gcgccgtgga tagagcagga ggg                                               23


<210>  792
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  792
cggctactac aaccagagcg agg                                               23


<210>  793
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  793
ctggttgtag tagccgcgca ggg                                               23


<210>  794
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  794
tactacaacc agagcgaggc cgg                                               23


<210>  795
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  795
ctacctggag ggcacgtgcg tgg                                               23


<210>  796
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  796
cacgcacgtg ccctccaggt agg                                               23


<210>  797
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  797
gcagggtccc caggtccact cgg                                               23


<210>  798
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  798
gtggacctgg ggaccctgcg cgg                                               23


<210>  799
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  799
tggagggcac gtgcgtggag tgg                                               23


<210>  800
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  800
gtatggctgc gacgtggggt cgg                                               23


<210>  801
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  801
ctgagctgcc atgtccgccg cgg                                               23


<210>  802
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  802
ggattacatc gccctgaaag agg                                               23


<210>  803
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  803
caagtgggag gcggcccatg tgg                                               23


<210>  804
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  804
gtgggaggcg gcccatgtgg cgg                                               23


<210>  805
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  805
cagttgagag cctacctgga ggg                                               23


<210>  806
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  806
gcagttgaga gcctacctgg agg                                               23


<210>  807
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  807
taccaccagt acgcctacga cgg                                               23


<210>  808
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  808
tgccgtcgta ggcgtactgg tgg                                               23


<210>  809
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  809
ccagtacgcc tacgacggca agg                                               23


<210>  810
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  810
ggatgtgaag aaatacctca tgg                                               23


<210>  811
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  811
atttcttcac atccgtgtcc cgg                                               23


<210>  812
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  812
aggcgtactg gtggtacccg cgg                                               23


<210>  813
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  813
cgtactggtg gtacccgcgg agg                                               23


<210>  814
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  814
gaggatgtat ggctgcgacg tgg                                               23


<210>  815
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  815
ggatgtatgg ctgcgacgtg ggg                                               23


<210>  816
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  816
ctcagaccac caagcacaag tgg                                               23


<210>  817
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  817
tcagaccacc aagcacaagt ggg                                               23


<210>  818
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  818
caccaagcac aagtgggagg cgg                                               23


<210>  819
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  819
gaccaccaag cacaagtggg agg                                               23


<210>  820
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  820
gagccccgct tcatcgcagt ggg                                               23


<210>  821
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  821
gtagcccact gcgatgaagc ggg                                               23


<210>  822
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  822
tagcccactg cgatgaagcg ggg                                               23


<210>  823
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  823
cgtagcccac tgcgatgaag cgg                                               23


<210>  824
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  824
cttcatcgca gtgggctacg tgg                                               23


<210>  825
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  825
ggagccccgc ttcatcgcag tgg                                               23


<210>  826
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  826
cggggagaca cggaaagtga agg                                               23


<210>  827
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  827
agtattggga cggggagaca cgg                                               23


<210>  828
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  828
agggtccgga gtattgggac ggg                                               23


<210>  829
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  829
gagggtccgg agtattggga cgg                                               23


<210>  830
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  830
ggaccctcct gctctatcca cgg                                               23


<210>  831
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  831
gtggatagag caggagggtc cgg                                               23


<210>  832
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  832
agactcaccg agtggacctg ggg                                               23


<210>  833
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  833
cactcggtga gtctgtgagt ggg                                               23


<210>  834
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  834
cagactcacc gagtggacct ggg                                               23


<210>  835
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  835
ccactcacag actcaccgag tgg                                               23


<210>  836
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  836
ccactcggtg agtctgtgag tgg                                               23


<210>  837
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  837
tcggactggc gcttcctccg cgg                                               23


<210>  838
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  838
gcagccatac atcctctgga cgg                                               23


<210>  839
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  839
tctcaactgc tccgccacat ggg                                               23


<210>  840
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  840
accctcatgc tgcacatggc agg                                               23


<210>  841
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  841
acctgccatg tgcagcatga ggg                                               23


<210>  842
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  842
cacctgccat gtgcagcatg agg                                               23


<210>  843
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  843
ggaggaccag acccaggaca cgg                                               23


<210>  844
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  844
ggatggggag gaccagaccc agg                                               23


<210>  845
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  845
gacctggcag cgggatgggg agg                                               23


<210>  846
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  846
agatcacact gacctggcag cgg                                               23


<210>  847
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  847
gatcacactg acctggcagc ggg                                               23


<210>  848
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  848
aggtcagtgt gatctccgca ggg                                               23


<210>  849
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  849
aagcccctca ccctgagatg ggg                                               23


<210>  850
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  850
ctgcggagat cacactgacc tgg                                               23


<210>  851
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  851
cagcaatgat gcccacgatg ggg                                               23


<210>  852
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  852
ccagcaatga tgcccacgat ggg                                               23


<210>  853
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  853
gccagcaatg atgcccacga tgg                                               23


<210>  854
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  854
ggatggaacc ttccagaagt ggg                                               23


<210>  855
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  855
gggatggaac cttccagaag tgg                                               23


<210>  856
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  856
atgcccacga tggggatggt ggg                                               23


<210>  857
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  857
cagcccacca tccccatcgt ggg                                               23


<210>  858
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  858
ccagcccacc atccccatcg tgg                                               23


<210>  859
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  859
gatgcccacg atggggatgg tgg                                               23


<210>  860
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  860
cagggcccag cacctcaggg tgg                                               23


<210>  861
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  861
aatgatgccc acgatgggga tgg                                               23


<210>  862
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  862
ggccctgacc cagacctggg cgg                                               23


<210>  863
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  863
gacccaggac acggagctcg tgg                                               23


<210>  864
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  864
acacggagct cgtggagacc agg                                               23


<210>  865
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  865
cgtggagacc aggcctgcag ggg                                               23


<210>  866
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  866
tcgtggagac caggcctgca ggg                                               23


<210>  867
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  867
agctgtgatc actggagctg tgg                                               23


<210>  868
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  868
aaaaggaggg agctactctc agg                                               23


<210>  869
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  869
atgtggagga ggaagagctc agg                                               23


<210>  870
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  870
gtgtctctca cagcttgtaa agg                                               23


<210>  871
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  871
gagagacaca tcagagccct ggg                                               23


<210>  872
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  872
ctccgcaggg tagaagctca ggg                                               23


<210>  873
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  873
ggccctgagc ttctaccctg cgg                                               23


<210>  874
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  874
gctcagggcc cagcacctca ggg                                               23


<210>  875
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  875
tatctctgct cctgtccaga agg                                               23


<210>  876
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  876
agtagcagga cgagggttcg ggg                                               23


<210>  877
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  877
ccccgagagt agcaggacga ggg                                               23


<210>  878
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  878
ccctcgtcct gctactctcg ggg                                               23


<210>  879
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  879
cctcgtcctg ctactctcgg ggg                                               23


<210>  880
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  880
ctgtggtcgc tgctgtgatg tgg                                               23


<210>  881
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  881
tcgctgctgt gatgtggagg agg                                               23


<210>  882
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  882
tggtcgctgc tgtgatgtgg agg                                               23


<210>  883
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  883
cacagccgcc cacttctgga agg                                               23


<210>  884
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  884
ccagaagtgg gcggctgtgg tgg                                               23


<210>  885
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  885
tggaaccttc cagaagtggg cgg                                               23


<210>  886
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  886
tcacagctcc aaagagaacc agg                                               23


<210>  887
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  887
ctgaccatga agccaccctg agg                                               23


<210>  888
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  888
gcaaaccctc atgctgcaca tgg                                               23


<210>  889
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  889
tgaagccacc ctgaggtgct ggg                                               23


<210>  890
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  890
ggtgagtcat atgcgttttg ggg                                               23


<210>  891
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  891
gtgagtcata tgcgttttgg ggg                                               23


<210>  892
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  892
cttcatggtc agagacagcg tgg                                               23


<210>  893
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Guide Nucleic Acid Targeting Sequence

<400>  893
tctggccctg acccagacct ggg                                               23


<210>  894
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  894
cgcgagcaca gctaaggcca                                                   20


<210>  895
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  895
gagtagcgcg agcacagcta                                                   20


<210>  896
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  896
agggtaggag agactcacgc                                                   20


<210>  897
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  897
ctgaatcttt ggagtacctg                                                   20


<210>  898
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  898
tcacgtcatc cagcagagaa                                                   20


<210>  899
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  899
tcctgaattg ctatgtgtct                                                   20


<210>  900
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  900
aagtcaactt caatgtcgga                                                   20


<210>  901
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  901
gtcttttccc gatattcctc                                                   20


<210>  902
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  902
tggagtacct gaggaatatc                                                   20


<210>  903
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  903
cagcccaaga tagttaagtg                                                   20


<210>  904
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  904
acaaagtcac atggttcaca                                                   20


<210>  905
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  905
actctctctt tctggcctgg                                                   20


<210>  906
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  906
tgggctgtga caaagtcaca                                                   20


<210>  907
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  907
ggccgagatg tctcgctccg                                                   20


<210>  908
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  908
cagtaagtca acttcaatgt                                                   20


<210>  909
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  909
actcacgctg gatagcctcc                                                   20


<210>  910
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  910
catactcatc tttttcagtg                                                   20


<210>  911
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  911
cacagcccaa gatagttaag                                                   20


<210>  912
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  912
ttcagacttg tctttcagca                                                   20


<210>  913
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  913
agtcacatgg ttcacacggc                                                   20


<210>  914
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  914
atactcatct ttttcagtgg                                                   20


<210>  915
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  915
ggcatactca tctttttcag                                                   20


<210>  916
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  916
acagcccaag atagttaagt                                                   20


<210>  917
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  917
gctactctct ctttctggcc                                                   20


<210>  918
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  918
tggagagaga attgaaaaag                                                   20


<210>  919
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  919
acttgtcttt cagcaaggac                                                   20


<210>  920
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  920
gaagttgact tactgaagaa                                                   20


<210>  921
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  921
ggccacggag cgagacatct                                                   20


<210>  922
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  922
gcatactcat ctttttcagt                                                   20


<210>  923
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  923
cgtgagtaaa cctgaatctt                                                   20


<210>  924
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  924
ttaccccact taactatctt                                                   20


<210>  925
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  925
ttggagtacc tgaggaatat                                                   20


<210>  926
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  926
acccagacac atagcaattc                                                   20


<210>  927
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  927
tttgactttc cattctctgc                                                   20


<210>  928
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  928
ttcctgaatt gctatgtgtc                                                   20


<210>  929
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  929
ctcaggtact ccaaagattc                                                   20


<210>  930
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  930
cttaccccac ttaactatct                                                   20


<210>  931
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  931
ctcgcgctac tctctctttc                                                   20


<210>  932
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  932
tcgatctatg aaaaagacag                                                   20


<210>  933
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  933
gagacatgta agcagcatca                                                   20


<210>  934
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  934
acatgtaagc agcatcatgg                                                   20


<210>  935
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  935
gaagtcctag aatgagcgcc                                                   20


<210>  936
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  936
gagcgcccgg tgtcccaagc                                                   20


<210>  937
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  937
agcgcccggt gtcccaagct                                                   20


<210>  938
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  938
gcgcccggtg tcccaagctg                                                   20


<210>  939
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  939
ctggggcgcg caccccagat                                                   20


<210>  940
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  940
gggcgcgcac cccagatcgg                                                   20


<210>  941
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  941
ggcgcgcacc ccagatcgga                                                   20


<210>  942
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  942
catcacgaga ctctaagaaa                                                   20


<210>  943
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  943
taagaaaagg aaactgaaaa                                                   20


<210>  944
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  944
aagaaaagga aactgaaaac                                                   20


<210>  945
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  945
gaaagtccct ctctctaacc                                                   20


<210>  946
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  946
ctaacctggc actgcgtcgc                                                   20


<210>  947
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  947
ctggcactgc gtcgctggct                                                   20


<210>  948
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  948
tgcgtcgctg gcttggagac                                                   20


<210>  949
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  949
gctggcttgg agacaggtga                                                   20


<210>  950
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  950
gagacaggtg acggtccctg                                                   20


<210>  951
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  951
agacaggtga cggtccctgc                                                   20


<210>  952
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  952
cctgcgggcc ttgtcctgat                                                   20


<210>  953
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  953
cgggccttgt cctgattggc                                                   20


<210>  954
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  954
gggccttgtc ctgattggct                                                   20


<210>  955
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  955
gggcacgcgt ttaatataag                                                   20


<210>  956
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  956
cacgcgttta atataagtgg                                                   20


<210>  957
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  957
tataagtgga ggcgtcgcgc                                                   20


<210>  958
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  958
aagtggaggc gtcgcgctgg                                                   20


<210>  959
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  959
agtggaggcg tcgcgctggc                                                   20


<210>  960
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  960
ttcctgaagc tgacagcatt                                                   20


<210>  961
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  961
tcctgaagct gacagcattc                                                   20


<210>  962
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  962
gcccgaatgc tgtcagcttc                                                   20


<210>  963
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  963
aaacgcgtgc ccagccaatc                                                   20


<210>  964
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  964
gtgcccagcc aatcaggaca                                                   20


<210>  965
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  965
ccaatcagga caaggcccgc                                                   20


<210>  966
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  966
caatcaggac aaggcccgca                                                   20


<210>  967
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  967
caagccagcg acgcagtgcc                                                   20


<210>  968
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  968
cgcagtgcca ggttagagag                                                   20


<210>  969
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  969
gcagtgccag gttagagaga                                                   20


<210>  970
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  970
gagtctcgtg atgtttaaga                                                   20


<210>  971
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  971
taagaaggca tgcactagac                                                   20


<210>  972
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  972
aagaaggcat gcactagact                                                   20


<210>  973
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  973
tgagtttgct gtctgtacat                                                   20


<210>  974
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  974
tacatcggcg ccctccgatc                                                   20


<210>  975
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  975
acatcggcgc cctccgatct                                                   20


<210>  976
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  976
catcggcgcc ctccgatctg                                                   20


<210>  977
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  977
ctggggtgcg cgccccagct                                                   20


<210>  978
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  978
tggggtgcgc gccccagctt                                                   20


<210>  979
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  979
cgcgccccag cttgggacac                                                   20


<210>  980
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  980
gcgccccagc ttgggacacc                                                   20


<210>  981
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  981
caagtcactt agcatctctg                                                   20


<210>  982
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  982
acagaagttc tccttctgct                                                   20


<210>  983
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  983
attcaaagat cttaatcttc                                                   20


<210>  984
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  984
ttcaaagatc ttaatcttct                                                   20


<210>  985
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  985
ttttctcgaa tgaaaaatgc                                                   20


<210>  986
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  986
tgcaggtccg agcagttaac                                                   20


<210>  987
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  987
ggtccgagca gttaactggc                                                   20


<210>  988
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  988
gtccgagcag ttaactggct                                                   20


<210>  989
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  989
tccgagcagt taactggctg                                                   20


<210>  990
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  990
agcaagtcac ttagcatctc                                                   20


<210>  991
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  991
gcaagtcact tagcatctct                                                   20


<210>  992
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  992
tggggccagt ctgcaaagcg                                                   20


<210>  993
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  993
ggggccagtc tgcaaagcga                                                   20


<210>  994
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  994
gggccagtct gcaaagcgag                                                   20


<210>  995
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  995
ggccagtctg caaagcgagg                                                   20


<210>  996
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  996
ggacaccggg cgctcattct                                                   20


<210>  997
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  997
ggcgctcatt ctaggacttc                                                   20


<210>  998
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  998
ctcattctag gacttcaggc                                                   20


<210>  999
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  999
attctaggac ttcaggctgg                                                   20


<210>  1000
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  1000
ttcaggctgg aggcacatta                                                   20


<210>  1001
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  1001
tgccccctcg ctttgcagac                                                   20


<210>  1002
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  1002
gatgctaagt gacttgctaa                                                   20


<210>  1003
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  1003
gccccagcca gttaactgct                                                   20


<210>  1004
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  1004
gcatttttca ttcgagaaaa                                                   20


<210>  1005
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  1005
tttgaatgct acctagcaga                                                   20


<210>  1006
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  1006
ttctgtttat aactacagct                                                   20


<210>  1007
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence targeting B2M

<400>  1007
tctgtttata actacagctt                                                   20


<210>  1008
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1008
agagaatgga aagtcaaatt t                                                 21


<210>  1009
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1009
atggacatga tcttctttat a                                                 21


<210>  1010
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1010
tggacatgat cttctttata a                                                 21


<210>  1011
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1011
ggacatgatc ttctttataa t                                                 21


<210>  1012
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1012
tgacaggatt attggaaatt t                                                 21


<210>  1013
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1013
ttgtggttaa tctggtttat t                                                 21


<210>  1014
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1014
tgtggttaat ctggtttatt t                                                 21


<210>  1015
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1015
gcagagaatg gaaagtcaaa t                                                 21


<210>  1016
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1016
cagagaatgg aaagtcaaat t                                                 21


<210>  1017
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1017
gagaatggaa agtcaaattt c                                                 21


<210>  1018
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1018
gtcacagccc aagatagtta a                                                 21


<210>  1019
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1019
tgcttataca cttacacttt a                                                 21


<210>  1020
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1020
gcttatacac ttacacttta t                                                 21


<210>  1021
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1021
cttatacact tacactttat g                                                 21


<210>  1022
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1022
acatggacat gatcttcttt a                                                 21


<210>  1023
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1023
catggacatg atcttcttta t                                                 21


<210>  1024
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1024
atcaacatct tggtcagatt t                                                 21


<210>  1025
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1025
cttgcactca aagcttgtta a                                                 21


<210>  1026
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1026
agttaagcgt gcataagtta a                                                 21


<210>  1027
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1027
gcataagtta acttccaatt t                                                 21


<210>  1028
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1028
tacatactct gcttagaatt t                                                 21


<210>  1029
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1029
acatactctg cttagaattt g                                                 21


<210>  1030
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1030
ttgacaggat tattggaaat t                                                 21


<210>  1031
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1031
gacaggatta ttggaaattt g                                                 21


<210>  1032
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1032
taaggcatgg ttgtggttaa t                                                 21


<210>  1033
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1033
gttgtggtta atctggttta t                                                 21


<210>  1034
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1034
gttccacaag ttaaataaat c                                                 21


<210>  1035
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1035
tccagcgtac tccaaagatt c                                                 21


<210>  1036
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1036
tactccaaag attcaggttt a                                                 21


<210>  1037
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1037
actccaaaga ttcaggttta c                                                 21


<210>  1038
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1038
cacgtcatcc agcagagaat g                                                 21


<210>  1039
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1039
ggtttcatcc atccgacatt g                                                 21


<210>  1040
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1040
ccgacattga agttgactta c                                                 21


<210>  1041
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1041
tgaagaatgg agagagaatt g                                                 21


<210>  1042
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1042
gagcattcag acttgtcttt c                                                 21


<210>  1043
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1043
ttcagcaagg actggtcttt c                                                 21


<210>  1044
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1044
gcaaggactg gtctttctat c                                                 21


<210>  1045
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1045
cgtgtgaacc atgtgacttt g                                                 21


<210>  1046
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1046
ctttgtcaca gcccaagata g                                                 21


<210>  1047
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1047
tcacagccca agatagttaa g                                                 21


<210>  1048
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1048
agtgggatcg agacatgtaa g                                                 21


<210>  1049
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1049
aggtttgaag atgccgcatt t                                                 21


<210>  1050
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1050
ggtttgaaga tgccgcattt g                                                 21


<210>  1051
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1051
ttgatatgct tatacactta c                                                 21


<210>  1052
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1052
tgagtgctgt ctccatgttt g                                                 21


<210>  1053
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1053
tgtctccatg tttgatgtat c                                                 21


<210>  1054
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1054
tcaacatctt ggtcagattt g                                                 21


<210>  1055
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1055
tcagatttga actcttcaat c                                                 21


<210>  1056
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1056
ttcaatctct tgcactcaaa g                                                 21


<210>  1057
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1057
ttgcactcaa agcttgttaa g                                                 21


<210>  1058
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1058
actcaaagct tgttaagata g                                                 21


<210>  1059
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1059
agatagttaa gcgtgcataa g                                                 21


<210>  1060
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1060
tgcataagtt aacttccaat t                                                 21


<210>  1061
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1061
gttaacttcc aatttacata c                                                 21


<210>  1062
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1062
attgacagga ttattggaaa t                                                 21


<210>  1063
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1063
gtaaggcatg gttgtggtta a                                                 21


<210>  1064
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1064
ggttgtggtt aatctggttt a                                                 21


<210>  1065
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1065
ttcctgaagc tgacagcatt c                                                 21


<210>  1066
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1066
gctatccagc gtactccaaa g                                                 21


<210>  1067
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1067
catccagcag agaatggaaa g                                                 21


<210>  1068
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1068
caaatttcct gaattgctat g                                                 21


<210>  1069
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1069
attgctatgt gtctgggttt c                                                 21


<210>  1070
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1070
gaagatgccg catttggatt g                                                 21


<210>  1071
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1071
caatttacat actctgctta g                                                 21


<210>  1072
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1072
tatccagcgt actccaaaga t                                                 21


<210>  1073
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1073
atccagcgta ctccaaagat t                                                 21


<210>  1074
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1074
ctccaaagat tcaggtttac t                                                 21


<210>  1075
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1075
tgctatgtgt ctgggtttca t                                                 21


<210>  1076
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1076
tttcatccat ccgacattga a                                                 21


<210>  1077
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1077
gaagttgact tactgaagaa t                                                 21


<210>  1078
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1078
gaagaatgga gagagaattg a                                                 21


<210>  1079
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1079
agaatggaga gagaattgaa a                                                 21


<210>  1080
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1080
cagcaaggac tggtctttct a                                                 21


<210>  1081
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1081
agcaaggact ggtctttcta t                                                 21


<210>  1082
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1082
actttgtcac agcccaagat a                                                 21


<210>  1083
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1083
ttgtcacagc ccaagatagt t                                                 21


<210>  1084
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1084
tgtcacagcc caagatagtt a                                                 21


<210>  1085
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1085
cacagcccaa gatagttaag t                                                 21


<210>  1086
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1086
gcagcatcat ggaggtttga a                                                 21


<210>  1087
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1087
ccgcatttgg attggatgaa t                                                 21


<210>  1088
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1088
ttgagtgctg tctccatgtt t                                                 21


<210>  1089
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1089
agtgctgtct ccatgtttga t                                                 21


<210>  1090
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1090
ctgtctccat gtttgatgta t                                                 21


<210>  1091
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1091
tctaggaggg ctggcaactt a                                                 21


<210>  1092
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1092
caacatcttg gtcagatttg a                                                 21


<210>  1093
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1093
gtcagatttg aactcttcaa t                                                 21


<210>  1094
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1094
tcttgcactc aaagcttgtt a                                                 21


<210>  1095
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1095
tgcactcaaa gcttgttaag a                                                 21


<210>  1096
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1096
gcactcaaag cttgttaaga t                                                 21


<210>  1097
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1097
cactcaaagc ttgttaagat a                                                 21


<210>  1098
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1098
tcaaagcttg ttaagatagt t                                                 21


<210>  1099
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1099
caaagcttgt taagatagtt a                                                 21


<210>  1100
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1100
gatagttaag cgtgcataag t                                                 21


<210>  1101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1101
atagttaagc gtgcataagt t                                                 21


<210>  1102
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1102
tagttaagcg tgcataagtt a                                                 21


<210>  1103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1103
ttaagcgtgc ataagttaac t                                                 21


<210>  1104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1104
taagcgtgca taagttaact t                                                 21


<210>  1105
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1105
atttacatac tctgcttaga a                                                 21


<210>  1106
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1106
tttacatact ctgcttagaa t                                                 21


<210>  1107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1107
acaggattat tggaaatttg t                                                 21


<210>  1108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1108
caggattatt ggaaatttgt t                                                 21


<210>  1109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1109
aggcatggtt gtggttaatc t                                                 21


<210>  1110
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1110
cagcagagaa tggaaagtca a                                                 21


<210>  1111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1111
tccgacattg aagttgactt a                                                 21


<210>  1112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1112
ctggtctttc tatctcttgt a                                                 21


<210>  1113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1113
ccgtgtgaac catgtgactt t                                                 21


<210>  1114
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1114
cccaagatag ttaagtggga t                                                 21


<210>  1115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1115
ggttgctcca caggtagctc t                                                 21


<210>  1116
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1116
gctccacagg tagctctagg a                                                 21


<210>  1117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1117
gggagcagag aattctctta t                                                 21


<210>  1118
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1118
ggagcagaga attctcttat c                                                 21


<210>  1119
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1119
gagcagagaa ttctcttatc c                                                 21


<210>  1120
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1120
gagaattctc ttatccaaca t                                                 21


<210>  1121
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1121
gaattctctt atccaacatc a                                                 21


<210>  1122
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1122
aagtggagca ttcagacttg t                                                 21


<210>  1123
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1123
aaggactggt ctttctatct c                                                 21


<210>  1124
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1124
aagcttgtta agatagttaa g                                                 21


<210>  1125
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1125
aagcgtgcat aagttaactt c                                                 21


<210>  1126
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1126
aagatgccgc atttggattg g                                                 21


<210>  1127
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1127
aagaatggag agagaattga a                                                 21


<210>  1128
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1128
aacatcaaca tcttggtcag a                                                 21


<210>  1129
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1129
aaggcatggt tgtggttaat c                                                 21


<210>  1130
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1130
aagcagcatc atggaggttt g                                                 21


<210>  1131
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1131
aagatgagta tgcctgccgt g                                                 21


<210>  1132
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1132
aagttgactt actgaagaat g                                                 21


<210>  1133
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1133
aagatagtta agcgtgcata a                                                 21


<210>  1134
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1134
aacttccaat ttacatactc t                                                 21


<210>  1135
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1135
aacatcttgg tcagatttga a                                                 21


<210>  1136
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1136
aactcttcaa tctcttgcac t                                                 21


<210>  1137
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1137
aatttcctga attgctatgt g                                                 21


<210>  1138
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1138
aatggaaagt caaatttcct g                                                 21


<210>  1139
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1139
aaccatgtga ctttgtcaca g                                                 21


<210>  1140
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1140
aattgacagg attattggaa a                                                 21


<210>  1141
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1141
aattctctta tccaacatca a                                                 21


<210>  1142
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1142
aaagtggagc attcagactt g                                                 21


<210>  1143
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1143
aaagtcaaat ttcctgaatt g                                                 21


<210>  1144
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1144
gttgctccac aggtagctct a                                                 21


<210>  1145
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target B2M sequence complement

<400>  1145
aatttacata ctctgcttag a                                                 21


<210>  1146
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1146
cttcttcctt ccctattaaa a                                                 21


<210>  1147
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1147
tctcactcca tgaggtattt c                                                 21


<210>  1148
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1148
ctctcactcc atgaggtatt t                                                 21


<210>  1149
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1149
gaggaggaag agctcagata g                                                 21


<210>  1150
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1150
gctctcactc catgaggtat t                                                 21


<210>  1151
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1151
aggattacat cgccctgaaa g                                                 21


<210>  1152
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1152
acaccgtcca gaggatgtat g                                                 21


<210>  1153
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1153
agggtccttc ttcctggata c                                                 21


<210>  1154
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1154
cctacgacgg caaggattac a                                                 21


<210>  1155
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1155
tcactccatg aggtatttct t                                                 21


<210>  1156
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1156
ctacgacggc aaggattaca t                                                 21


<210>  1157
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1157
ctcactccat gaggtatttc t                                                 21


<210>  1158
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1158
ggaggaagag ctcagataga a                                                 21


<210>  1159
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1159
cacaccgtcc agaggatgta t                                                 21


<210>  1160
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1160
cacgctgtct ctgaccatga a                                                 21


<210>  1161
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1161
ctggacagga gcagagatac a                                                 21


<210>  1162
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1162
tggaggagga agagctcaga t                                                 21


<210>  1163
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1163
ggctctcact ccatgaggta t                                                 21


<210>  1164
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1164
catctctgtc tcaacttcat g                                                 21


<210>  1165
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1165
tacgacggca aggattacat c                                                 21


<210>  1166
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1166
ggattacatc gccctgaaag a                                                 21


<210>  1167
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1167
gattacatcg ccctgaaaga g                                                 21


<210>  1168
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1168
ctcagaccac caagcacaag t                                                 21


<210>  1169
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1169
tcacaccgtc cagaggatgt a                                                 21


<210>  1170
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1170
actccatgag gtatttcttc a                                                 21


<210>  1171
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1171
cactccatga ggtatttctt c                                                 21


<210>  1172
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1172
ccatgaggta tttcttcaca t                                                 21


<210>  1173
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1173
acttcttcct tccctattaa a                                                 21


<210>  1174
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1174
gtgtctctca cagcttgtaa a                                                 21


<210>  1175
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1175
ctgtgttcgt gtaggcataa t                                                 21


<210>  1176
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1176
tgtgttcgtg taggcataat g                                                 21


<210>  1177
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1177
taacttcttc cttccctatt a                                                 21


<210>  1178
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1178
tctggacagg agcagagata c                                                 21


<210>  1179
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1179
ttgctggcct ggttctcttt g                                                 21


<210>  1180
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1180
tgtctctcac agcttgtaaa g                                                 21


<210>  1181
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1181
acttgaagaa ccctgacttt g                                                 21


<210>  1182
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1182
gaagaaccct gactttgttt c                                                 21


<210>  1183
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1183
tctgtgttcg tgtaggcata a                                                 21


<210>  1184
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1184
catggtgcac tgagctgtaa c                                                 21


<210>  1185
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1185
gtaacttctt ccttccctat t                                                 21


<210>  1186
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1186
catgtgcagc atgagggttt g                                                 21


<210>  1187
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1187
ttgttcctgc ccttcccttt g                                                 21


<210>  1188
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1188
acccagttct cactcccatt g                                                 21


<210>  1189
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1189
gggtttccag agaagccaat c                                                 21


<210>  1190
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1190
ttctccctct cccaacctat g                                                 21


<210>  1191
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1191
gtctctcaca gcttgtaaag t                                                 21


<210>  1192
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1192
tgtgtctctc acagcttgta a                                                 21


<210>  1193
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1193
gaggaagagc tcagatagaa a                                                 21


<210>  1194
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1194
tgaagaaccc tgactttgtt t                                                 21


<210>  1195
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1195
ttgaagaacc ctgactttgt t                                                 21


<210>  1196
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1196
gtgttcgtgt aggcataatg t                                                 21


<210>  1197
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1197
tggtgcactg agctgtaact t                                                 21


<210>  1198
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1198
ctccctctcc caacctatgt a                                                 21


<210>  1199
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1199
aggaggaaga gctcagatag a                                                 21


<210>  1200
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1200
acctatgtag ggtccttctt c                                                 21


<210>  1201
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1201
gggtccttct tcctggatac t                                                 21


<210>  1202
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1202
ggtccttctt cctggatact c                                                 21


<210>  1203
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1203
gtccttcttc ctggatactc a                                                 21


<210>  1204
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1204
aagccaatca gtgtcgtcgc g                                                 21


<210>  1205
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1205
aagaggacct gcgctcttgg a                                                 21


<210>  1206
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1206
aagtgtgaga cagctgcctt g                                                 21


<210>  1207
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1207
aaggcacctg catgtgtctg t                                                 21


<210>  1208
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1208
aatcatcttt cctgttccag a                                                 21


<210>  1209
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1209
aaaggcacct gcatgtgtct g                                                 21


<210>  1210
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1210
aaagaggacc tgcgctcttg g                                                 21


<210>  1211
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1211
aaacgcatat gactcaccac g                                                 21


<210>  1212
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1212
ggaagagctc agatagaaa                                                    19


<210>  1213
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1213
gggagacacg gaaagtgaa                                                    19


<210>  1214
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1214
cacctgccat gtgcagcatg a                                                 21


<210>  1215
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1215
ggagatcaca ctgacctggc a                                                 21


<210>  1216
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1216
ggattacatc gccctgaaag                                                   20


<210>  1217
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1217
gcaggagggt ccggagtatt                                                   20


<210>  1218
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1218
ggacggggag acacggaaag                                                   20


<210>  1219
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1219
gaaagtgaag gcccactca                                                    19


<210>  1220
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1220
gatacctgga gaacgggaag                                                   20


<210>  1221
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1221
gctgtggtgg tgccttctgg                                                   20


<210>  1222
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1222
gctactacaa ccagagcgag                                                   20


<210>  1223
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1223
gtggctccgc agatacctg                                                    19


<210>  1224
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1224
gccaatcagt gtcgtcgcg                                                    19


<210>  1225
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1225
gaggacctgc gctcttgga                                                    19


<210>  1226
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1226
gtgtgagaca gctgccttg                                                    19


<210>  1227
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1227
ggcacctgca tgtgtctgt                                                    19


<210>  1228
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1228
tcatctttcc tgttccaga                                                    19


<210>  1229
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1229
aggcacctgc atgtgtctg                                                    19


<210>  1230
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1230
agaggacctg cgctcttgg                                                    19


<210>  1231
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  target HLA sequence complement

<400>  1231
acgcatatga ctcaccacg                                                    19


<210>  1232
<211>  2
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  5' Flank Sequence

<400>  1232
gg                                                                       2


<210>  1233
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  5' Flank Sequence

<400>  1233
acaccauguu gccagucucu agg                                               23


<210>  1234
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  5' Flank Sequence

<400>  1234
ugauagcaau gucagcagug ccu                                               23


<210>  1235
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  5' Flank Sequence

<400>  1235
uauugcuguu gacagugagc gac                                               23


<210>  1236
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  3' Flank Sequence

<400>  1236
uggcgucugg cccaaccaca c                                                 21


<210>  1237
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  3' Flank Sequence

<400>  1237
guaagguuga ccauacucua c                                                 21


<210>  1238
<211>  4
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1238
cgaa                                                                     4


<210>  1239
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1239
uucaaga                                                                  7


<210>  1240
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1240
auauuca                                                                  7


<210>  1241
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1241
ugugcuguc                                                                9


<210>  1242
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1242
cucgag                                                                   6


<210>  1243
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1243
cuuccuguca ga                                                           12


<210>  1244
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1244
cuucccuuug ucaga                                                        15


<210>  1245
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1245
guguuauucu ug                                                           12


<210>  1246
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1246
gugucuuaau ug                                                           12


<210>  1247
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1247
guguuagucu ug                                                           12


<210>  1248
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1248
ucaagag                                                                  7


<210>  1249
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1249
ggacauccag gg                                                           12


<210>  1250
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1250
gugaagccac agaug                                                        15


<210>  1251
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Loop Region Sequence

<400>  1251
gauucuaaaa                                                              10


<210>  1252
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  PA2.1.14 (VL:VH) scFv LIR1 sHTICD

<400>  1252
gacattcaaa tgacccagag cccatccacc ctgagcgcat ctgtaggtga ccgggtcacc       60

atcacttgta gatccagtca gagtattgta cacagtaatg ggaacaccta tttggaatgg      120

tatcagcaga aaccaggtaa agccccaaaa ttgctcatct acaaagtctc taacagattt      180

agtggtgtac cagccaggtt cagcggttcc ggaagtggta ctgaattcac cctcacgatc      240

tcctctctcc agccagatga tttcgccact tattactgtt ttcaaggttc acatgtgccg      300

cgcacattcg gtcagggtac taaagtagaa gtcaaaggcg gaggtggaag cggaggggga      360

ggatctggcg gcggaggaag cggaggccag gtgcagctgg tgcagtctgg ggctgaggtg      420

aagaagcctg ggtcctcagt gaaggtttcc tgcaaggctt ctggatacac cttcactagc      480

tatcatatac attgggtgcg ccaggccccc ggacaagggc ttgagtggat cggatggatc      540

taccctggca atgttaacac agaatataat gagaagttca agggcaaagc caccattacc      600

gcggacgaat ccacgaacac agcctacatg gagctgagca gcctgagatc tgaagacacg      660

gctgtgtatt actgtgcgag ggaggaaatt acctacgcta tggactactg gggccaggga      720

accctggtca ccgtgtcctc agtggtctca ggaccgtctg ggggccccag ctccccgaca      780

acaggcccca cctccacatc tggccctgag gaccagcccc tcacccccac cgggtcggat      840

ccccagagtg gtctgggaag gcacctgggg gttgtgatcg gcatcttggt ggccgtcatc      900

ctactgctcc tcctcctcct cctcctcttc ctcatcctcc gacatcgacg tcagggcaaa      960

cactggacat cgacccagag aaaggctgat ttccaacatc ctgcaggggc tgtggggcca     1020

gagcccacag acagaggcct gcagtggagg tccagcccag ctgccgatgc ccaggaagaa     1080

aacctctatg ctgccgtgaa gcacacacag cctgaggatg gggtggagat ggacactcgg     1140

agcccacacg atgaagaccc ccaggcagtg acgtatgccg aggtgaaaca ctccagacct     1200

aggagagaaa tggcctctcc tccttcccca ctgtctgggg aattcctgga cacaaaggac     1260

agacaggcgg aagaggacag gcagatggac actgaggctg ctgcatctga agccccccag     1320

gatgtgacct acgcccagct gcacagcttg accctcagac gggaggcaac tgagcctcct     1380

ccatcccagg aagggccctc tccagctgtg cccagcatct acgccactct ggccatccac     1440

tag                                                                   1443


<210>  1253
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  PA2.1.14 (VL:VH) scFv LIR1 HTICD

<400>  1253
gacattcaaa tgacccagag cccatccacc ctgagcgcat ctgtaggtga ccgggtcacc       60

atcacttgta gatccagtca gagtattgta cacagtaatg ggaacaccta tttggaatgg      120

tatcagcaga aaccaggtaa agccccaaaa ttgctcatct acaaagtctc taacagattt      180

agtggtgtac cagccaggtt cagcggttcc ggaagtggta ctgaattcac cctcacgatc      240

tcctctctcc agccagatga tttcgccact tattactgtt ttcaaggttc acatgtgccg      300

cgcacattcg gtcagggtac taaagtagaa gtcaaaggcg gaggtggaag cggaggggga      360

ggatctggcg gcggaggaag cggaggccag gtgcagctgg tgcagtctgg ggctgaggtg      420

aagaagcctg ggtcctcagt gaaggtttcc tgcaaggctt ctggatacac cttcactagc      480

tatcatatac attgggtgcg ccaggccccc ggacaagggc ttgagtggat cggatggatc      540

taccctggca atgttaacac agaatataat gagaagttca agggcaaagc caccattacc      600

gcggacgaat ccacgaacac agcctacatg gagctgagca gcctgagatc tgaagacacg      660

gctgtgtatt actgtgcgag ggaggaaatt acctacgcta tggactactg gggccaggga      720

accctggtca ccgtgtcctc atacggctca cagagctcca aaccctacct gctgactcac      780

cccagtgacc ccctggagct cgtggtctca ggaccgtctg ggggccccag ctccccgaca      840

acaggcccca cctccacatc tggccctgag gaccagcccc tcacccccac cgggtcggat      900

ccccagagtg gtctgggaag gcacctgggg gttgtgatcg gcatcttggt ggccgtcatc      960

ctactgctcc tcctcctcct cctcctcttc ctcatcctcc gacatcgacg tcagggcaaa     1020

cactggacat cgacccagag aaaggctgat ttccaacatc ctgcaggggc tgtggggcca     1080

gagcccacag acagaggcct gcagtggagg tccagcccag ctgccgatgc ccaggaagaa     1140

aacctctatg ctgccgtgaa gcacacacag cctgaggatg gggtggagat ggacactcgg     1200

agcccacacg atgaagaccc ccaggcagtg acgtatgccg aggtgaaaca ctccagacct     1260

aggagagaaa tggcctctcc tccttcccca ctgtctgggg aattcctgga cacaaaggac     1320

agacaggcgg aagaggacag gcagatggac actgaggctg ctgcatctga agccccccag     1380

gatgtgacct acgcccagct gcacagcttg accctcagac gggaggcaac tgagcctcct     1440

ccatcccagg aagggccctc tccagctgtg cccagcatct acgccactct ggccatccac     1500

tag                                                                   1503


<210>  1254
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MSLN_SsI CD8_HT 41BB CD3z

<400>  1254
caagtccagc tccagcagtc gggcccagag ttggagaagc ctggggcgag cgtgaagatc       60

tcatgcaaag cctcaggcta ctcctttact ggatacacga tgaattgggt gaaacagtcg      120

catggaaagt cactggaatg gatcggtctg attacgccct acaacggcgc ctccagctac      180

aaccagaagt tcaggggaaa ggcgaccctt actgtcgaca agtcgtcaag caccgcctac      240

atggacctcc tgtccctgac ctccgaagat agcgcggtct acttttgtgc acgcggaggt      300

tacgatggac ggggattcga ctactggggc cagggaacca ctgtcaccgt gtcgagcgga      360

ggcggaggga gcggaggagg aggcagcgga ggtggagggt cggatatcga actcactcag      420

tccccagcaa tcatgtccgc ttcaccggga gaaaaggtga ccatgacttg ctcggcctcc      480

tcgtccgtgt catacatgca ctggtaccaa caaaaatcgg ggacctcccc taagagatgg      540

atctacgata ccagcaaact ggcttcaggc gtgccgggac gcttctcggg ttcggggagc      600

ggaaattcgt attcgttgac catttcgtcc gtggaagccg aggacgacgc aacttattac      660

tgccaacagt ggtcaggcta cccgctcact ttcggagccg gcactaagct ggagatcacc      720

actaccccag caccgaggcc acccaccccg gctcctacca tcgcctccca gcctctgtcc      780

ctgcgtccgg aggcatgtag acccgcagct ggtggggccg tgcatacccg gggtcttgac      840

ttcgcctgcg atatctacat ttgggcccct ctggctggta cttgcggggt cctgctgctt      900

tcactcgtga tcactcttta ctgtaagcgc ggtcggaaga agctgctgta catctttaag      960

caacccttca tgaggcctgt gcagactact caagaggagg acggctgttc atgccggttc     1020

ccagaggagg aggaaggcgg ctgcgaactg cgcgtgaaat tcagccgcag cgcagatgct     1080

ccagcctaca agcaggggca gaaccagctc tacaacgaac tcaatcttgg tcggagagag     1140

gagtacgacg tgctggacaa gcggagagga cgggacccag aaatgggcgg gaagccgcgc     1200

agaaagaatc cccaagaggg cctgtacaac gagctccaaa aggataagat ggcagaagcc     1260

tatagcgaga ttggtatgaa aggggaacgc agaagaggca aaggccacga cggactgtac     1320

cagggactca gcaccgccac caaggacacc tatgacgctc ttcacatgca ggccctgccg     1380

cctcgg                                                                1386


<210>  1255
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  PA2.1.14 scFv LIR1 sHTICD

<400>  1255
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggacg aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagcc      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa agtggtctca ggaccgtctg ggggccccag ctccccgaca      780

acaggcccca cctccacatc tggccctgag gaccagcccc tcacccccac cgggtcggat      840

ccccagagtg gtctgggaag gcacctgggg gttgtgatcg gcatcttggt ggccgtcatc      900

ctactgctcc tcctcctcct cctcctcttc ctcatcctcc gacatcgacg tcagggcaaa      960

cactggacat cgacccagag aaaggctgat ttccaacatc ctgcaggggc tgtggggcca     1020

gagcccacag acagaggcct gcagtggagg tccagcccag ctgccgatgc ccaggaagaa     1080

aacctctatg ctgccgtgaa gcacacacag cctgaggatg gggtggagat ggacactcgg     1140

agcccacacg atgaagaccc ccaggcagtg acgtatgccg aggtgaaaca ctccagacct     1200

aggagagaaa tggcctctcc tccttcccca ctgtctgggg aattcctgga cacaaaggac     1260

agacaggcgg aagaggacag gcagatggac actgaggctg ctgcatctga agccccccag     1320

gatgtgacct acgcccagct gcacagcttg accctcagac gggaggcaac tgagcctcct     1380

ccatcccagg aagggccctc tccagctgtg cccagcatct acgccactct ggccatccac     1440

tag                                                                   1443


