                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
 
<120>  SHANK3 GENE THERAPY APPROACHES

<130>  B1195.70108WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/066,570
<151>  2020-08-17

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  2121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
atgggcccga agcggaaact ttacagtgcc gtccccggcc gcaagttcat cgctgtgaag       60

gcgcacagcc cgcagggcga gggcgagatc ccgctgcacc gcggcgaggc cgtgaaggtg      120

ctcagcattg gggagggcgg tttctgggag ggaaccgtga agggccgaac aggctggttc      180

ccagctgact gtgtggaaga agtgcagatg cgacagtatg acacccggca tgaaaccaga      240

gaggaccgga cgaagcgtct cttccgccac tacactgtgg gttcctatga cagcctcact      300

tcacacagcg attatgtcat cgatgataag gtggctatcc tgcagaaaag ggaccatgag      360

gggtttggct ttgttctccg gggagccaaa gcagagaccc ccattgagga gtttacaccc      420

acacctgcct tccctgcact ccaatacctt gagtctgtag atgtggaagg tgtggcctgg      480

agggctggac ttcgaactgg ggacttcctc attgaggtga acggagtgaa tgtcgtgaag      540

gttggacaca agcaagtggt gggtctcatc cgtcagggtg gcaaccgcct ggtcatgaag      600

gttgtgtctg tgaccaggaa acccgaggag gatggtgctc ggcgcagagc cccaccaccc      660

ccaaagaggg ctcccagcac cacgctgacc ctgcggtcca agtccatgac ggctgagctc      720

gaggaacttg cttccattcg gagctcagag gaggagccag agctggtatt cgctgtgaac      780

ctgccacctg ctcagctgtc ctccagcgat gaggagacca gagaggagct ggcccgcata      840

gggctagtgc caccccctga agagtttgcc aatgggatcc tgctgaccac cccgccccca      900

gggccgggcc ccttgcccac cacggtaccc agcccggcct cagggaagcc cagcagcgag      960

ctgccccctg cccctgagtc tgcagctgac tctggagtag aggaggctga cactcgaagc     1020

tccagtgacc cccacctgga gaccacaagc accatttcca cagtgtccag catgtccacc     1080

ctgagctcgg agagtgggga actcacggac acccacacct cctttgccga tggacacact     1140

tttctactcg agaagccacc agtgcctccc aagcccaagc tcaagtcccc gctggggaag     1200

gggccggtga ccttcaggga cccgctgctg aagcaatcct cggacagtga gctcatggcc     1260

cagcagcacc atgctgcctc tactgggttg gcttctgctg ctgggcccgc ccgccctcgc     1320

tacctcttcc agagaaggtc caagctgtgg ggggaccccg tggagagtcg ggggctccct     1380

gggcctgaag atgacaaacc aactgtgatc agtgagctca gctcccgtct gcagcagctg     1440

aataaagaca cacgctcctt gggggaggaa ccagttggtg gcctgggcag cctgctggac     1500

cctgctaaga agtcacccat tgcagcagct cggctcttca gcagcctcgg tgagctgagc     1560

accatctcag cgcagcgcag cccggggggc ccgggcggag gggcctccta ctcggtgcgg     1620

cccagcggcc ggtaccccgt ggcgagacga gccccgagcc cagtgaaacc cgcatcgctg     1680

gagcgggtgg aggggctggg ggcgggcgtg ggaggcgcgg ggcggccctt cggcctcacg     1740

cctcccacca tcctcaagtc gtccagcctc tccatcccgc acgaacccaa ggaagtgcgc     1800

ttcgtggtgc gaagtgtgag tgcgcgcagc cgctccccct caccatctcc gctgccctcg     1860

ccttctcccg gctctggccc cagtgccggc ccgcgtcggc catttcaaca gaagcccctg     1920

cagctctgga gcaagttcga tgtgggcgac tggctggaga gcatccactt aggcgagcac     1980

cgagaccgct tcgaggacca tgagatcgaa ggcgcacacc tgcctgcgct caccaaggaa     2040

gacttcgtgg agctgggcgt cacacgcgtt ggccaccgca tgaacatcga gcgtgcgctc     2100

aggcagctgg atggcagctg a                                               2121


<210>  2
<211>  2124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
atgggcccga agcggaaact ttacagcgcc gtccccggcc gcaagttcat cgccgtgaag       60

gcgcacagcc cgcagggtga aggcgagatc ccgctgcacc gcggcgaggc cgtgaaggtg      120

ctcagcattg gggagggcgg tttctgggag ggaaccgtga aaggccgcac gggctggttc      180

ccggccgact gcgtggagga agtgcagatg aggcagcatg acacacggcc tgaaacgcgg      240

gaggaccgga cgaagcggct ctttcggcac tacacagtgg gctcctacga cagcctcacc      300

tcacacagcg attatgtcat tgatgacaaa gtggctgtcc tgcagaaacg ggaccacgag      360

ggctttggtt ttgtgctccg gggagccaaa gcagagaccc ccatcgagga gttcacgccc      420

acgccagcct tcccggcgct gcagtatctc gagtcggtgg acgtggaggg tgtggcctgg      480

agggccgggc tgcgcacggg agacttcctc atcgaggtga acggggtgaa cgtggtgaag      540

gtcggacaca agcaggtggt ggctctgatt cgccagggtg gcaaccgcct cgtcatgaag      600

gttgtgtctg tgacaaggaa gccagaagag gacggggctc ggcgcagagc cccaccgccc      660

cccaagaggg cccccagcac cacactgacc ctgcgctcca agtccatgac agctgagctc      720

gaggaacttg cctccattcg gagctcagag gaagagccag agctggtgtt tgctgtgaac      780

ctgccacctg cccagctgtc gtccagcgat gaggagacca gggaggagct ggcccgaatt      840

gggttggtgc caccccctga agagtttgcc aacggggtcc tgctggccac cccactcgct      900

ggcccgggcc cctcgcccac cacggtgccc agcccggcct cagggaagcc cagcagtgag      960

ccaccccctg cccctgagtc tgcagccgac tctggggtgg aggaggctga cacacgcagc     1020

tccagcgacc cccacctgga gaccacaagc accatctcca cggtgtccag catgtccacc     1080

ttgagctcgg agagcgggga actcactgac acccacacct ccttcgctga cggacacact     1140

tttctactcg agaagccacc agtgcctccc aagcccaagc tcaagtcccc gctggggaag     1200

gggccggtga ccttcaggga cccgctgctg aagcagtcct cggacagcga gctcatggcc     1260

cagcagcacc acgccgcctc tgccgggctg gcctctgccg ccgggcctgc ccgccctcgc     1320

tacctcttcc agagaaggtc caagctatgg ggggaccccg tggagagccg ggggctccct     1380

gggcctgaag acgacaaacc aactgtgatc agtgagctca gctcccgcct gcagcagctg     1440

aacaaggaca cgcgttccct gggggaggaa ccagttggtg gcctgggcag cctgctggac     1500

cctgccaaga agtcgcccat cgcagcagct cggctcttca gcagcctcgg tgagctgagc     1560

tccatttcag cgcagcgcag ccccgggggc ccgggcggcg gggcctcgta ctcggtgagg     1620

cccagtggcc gctaccccgt ggcgagacgc gccccgagcc cggtgaagcc cgcgtcgctg     1680

gagcgggtgg aggggctggg ggcgggcgcg gggggcgcag ggcggccctt cggcctcacg     1740

ccccccacca tcctcaagtc gtccagcctc tccatcccgc acgagcccaa ggaggtgcgc     1800

ttcgtggtgc gcagcgtgag cgcgcgcagt cgctccccct cgccgtcgcc gctgccctcg     1860

cccgcgtccg gccccggccc cggcgccccc ggcccacgcc gacccttcca gcagaagccg     1920

ctgcagctct ggagcaagtt cgacgtgggc gactggctgg agagcatcca cctaggcgag     1980

caccgcgacc gcttcgagga ccatgagata gaaggcgcgc acctacccgc gcttaccaag     2040

gacgacttcg tggagctggg cgtcacgcgc gtgggccacc gcatgaacat cgagcgcgcg     2100

ctcaggcagc tggacggcag ctga                                            2124


<210>  3
<211>  3276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
atggacggcc ccggggccag cgccgtggtc gtgcgcgtcg gcatcccgga cctgcaacaa       60

acgaagtgcc tgcgtctgga cccaaccgcg cccgtgtggg ccgccaagca gcgtgtgctc      120

tgcgccctca atcatagcct tcaagacgcg ctcaactacg ggctattcca gcctccctcc      180

cggggtcgcg ccggcaagtt cctggatgaa gagcggctct tacaggacta cccgcctaac      240

ctggacacgc ccctgcccta tctggagttc cgatacaagc ggagagttta tgcccagaac      300

ctcatagatg acaagcagtt tgcaaagcta cacacaaagg caaacctgaa gaagttcatg      360

gactatgtcc agctacacag cacagataag gtggcccgcc tgctggacaa ggggctggac      420

cccaatttcc atgaccctga ctcaggagag tgccctctga gccttgcggc acagttggac      480

aacgccactg acctcctgaa ggttctccgc aacggcggtg ctcatctgga cttccggacc      540

cgagatgggc tgacagccgt ccactgtgct acccgccagc ggaacgcagg ggcattgacg      600

accctgctgg acctgggggc ttcgcctgac tacaaggaca gccgcggcct gacgcccctg      660

taccatagtg ccctaggggg cggggatgcc ctctgttgcg agctgcttct ccatgatcat      720

gcacagctgg ggaccactga tgagaatggt tggcaagaga tccatcaggc ctgtcgcttt      780

ggacacgtgc agcacctgga gcaccttttg ttctatgggg ccaacatggg tgctcagaat      840

gcctcgggaa acacagccct gcacatctgt gccctctaca accaggagag ttgcgcgcgc      900

gtcctgcttt tccgtggtgc caacaaggac gtccgcaatt acaacagcca gacagccttc      960

caggtggcca ttattgcagg gaactttgag cttgccgagg taatcaagac ccacaaagac     1020

tccgatgtcg taccattcag ggaaaccccc agctatgcaa agcgacggcg tctggctggc     1080

ccgagtggcc tggcatcccc acggccctta cagcgctcag ccagtgatat caacctgaaa     1140

ggtgcgccgc cgccccgggg cccgaagcgg aaactttaca gtgccgtccc cggccgcaag     1200

ttcatcgctg tgaaggcgca cagcccgcag ggcgagggcg agatcccgct gcaccgcggc     1260

gaggccgtga aggtgctcag cattggggag ggcggtttct gggagggaac cgtgaagggc     1320

cgaacaggct ggttcccagc tgactgtgtg gaagaagtgc agatgcgaca gtatgacacc     1380

cggcatgaaa ccagagagga ccggacgaag cgtctcttcc gccactacac tgtgggttcc     1440

tatgacagcc tcacttcaca cagcgattat gtcatcgatg ataaggtggc tatcctgcag     1500

aaaagggacc atgaggggtt tggctttgtt ctccggggag ccaaagcaga gacccccatt     1560

gaggagttta cacccacacc tgccttccct gcactccaat accttgagtc tgtagatgtg     1620

gaaggtgtgg cctggagggc tggacttcga actggggact tcctcattga ggtgaacgga     1680

gtgaatgtcg tgaaggttgg acacaagcaa gtggtgggtc tcatccgtca gggtggcaac     1740

cgcctggtca tgaaggttgt gtctgtgacc aggaaacccg aggaggatgg tgctcggcgc     1800

agagccccac cacccccaaa gagggctccc agcaccacgc tgaccctgcg gtccaagtcc     1860

atgacggctg agctcgagga acttgcttcc attcggagct cagaggagga gccagagctg     1920

gtattcgctg tgaacctgcc acctgctcag ctgtcctcca gcgatgagga gaccagagag     1980

gagctggccc gcatagggct agtgccaccc cctgaagagt ttgccaatgg gatcctgctg     2040

accaccccgc ccccagggcc gggccccttg cccaccacgg tacccagccc ggcctcaggg     2100

aagcccagca gcgagctgcc ccctgcccct gagtctgcag ctgactctgg agtagaggag     2160

gctgacactc gaagctccag tgacccccac ctggagacca caagcaccat ttccacagtg     2220

tccagcatgt ccaccctgag ctcggagagt ggggaactca cggacaccca cacctccttt     2280

gccgatggac acacttttct actcgagaag ccaccagtgc ctcccaagcc caagctcaag     2340

tccccgctgg ggaaggggcc ggtgaccttc agggacccgc tgctgaagca atcctcggac     2400

agtgagctca tggcccagca gcaccatgct gcctctactg ggttggcttc tgctgctggg     2460

cccgcccgcc ctcgctacct cttccagaga aggtccaagc tgtgggggga ccccgtggag     2520

agtcgggggc tccctgggcc tgaagatgac aaaccaactg tgatcagtga gctcagctcc     2580

cgtctgcagc agctgaataa agacacacgc tccttggggg aggaaccagt tggtggcctg     2640

ggcagcctgc tggaccctgc taagaagtca cccattgcag cagctcggct cttcagcagc     2700

ctcggtgagc tgagcaccat ctcagcgcag cgcagcccgg ggggcccggg cggaggggcc     2760

tcctactcgg tgcggcccag cggccggtac cccgtggcga gacgagcccc gagcccagtg     2820

aaacccgcat cgctggagcg ggtggagggg ctgggggcgg gcgtgggagg cgcggggcgg     2880

cccttcggcc tcacgcctcc caccatcctc aagtcgtcca gcctctccat cccgcacgaa     2940

cccaaggaag tgcgcttcgt ggtgcgaagt gtgagtgcgc gcagccgctc cccctcacca     3000

tctccgctgc cctcgccttc tcccggctct ggccccagtg ccggcccgcg tcggccattt     3060

caacagaagc ccctgcagct ctggagcaag ttcgatgtgg gcgactggct ggagagcatc     3120

cacttaggcg agcaccgaga ccgcttcgag gaccatgaga tcgaaggcgc acacctgcct     3180

gcgctcacca aggaagactt cgtggagctg ggcgtcacac gcgttggcca ccgcatgaac     3240

atcgagcgtg cgctcaggca gctggatggc agctga                               3276


<210>  4
<211>  3279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
atggacggcc ccggggccag cgccgtggtc gtgcgcgtcg gcatcccgga cctgcagcag       60

acgaagtgcc tgcgcctgga cccggccgcg cccgtgtggg ccgccaagca gcgcgtgctc      120

tgcgccctca accacagcct ccaggacgcg ctcaactatg ggcttttcca gccgccctcc      180

cggggccgcg ccggcaagtt cctggatgag gagcggctcc tgcaggagta cccgcccaac      240

ctggacacgc ccctgcccta cctggagttt cgatacaagc ggcgagttta tgcccagaac      300

ctcatcgatg ataagcagtt tgcaaagctt cacacaaagg cgaacctgaa gaagttcatg      360

gactacgtcc agctgcatag cacggacaag gtggcacgcc tgttggacaa ggggctggac      420

cccaacttcc atgaccctga ctcaggagag tgccccctga gcctcgcagc ccagctggac      480

aacgccacgg acctgctaaa ggtgctgaag aatggtggtg cccacctgga cttccgcact      540

cgcgatgggc tcactgccgt gcactgtgcc acacgccagc ggaatgcggc agcactgacg      600

accctgctgg acctgggggc ttcacctgac tacaaggaca gccgcggctt gacacccctc      660

taccacagcg ccctgggggg tggggatgcc ctctgctgtg agctgcttct ccacgaccac      720

gctcagctgg ggatcaccga cgagaatggc tggcaggaga tccaccaggc ctgccgcttt      780

gggcacgtgc agcatctgga gcacctgctg ttctatgggg cagacatggg ggcccagaac      840

gcctcgggga acacagccct gcacatctgt gccctctaca accaggagag ctgtgctcgt      900

gtcctgctct tccgtggagc taacagggat gtccgcaact acaacagcca gacagccttc      960

caggtggcca tcatcgcagg gaactttgag cttgcagagg ttatcaagac ccacaaagac     1020

tcggatgttg taccattcag ggaaaccccc agctatgcga agcggcggcg actggctggc     1080

cccagtggct tggcatcccc tcggcctctg cagcgctcag ccagcgatat caacctgaag     1140

ggggcaccgc cgccccgggg cccgaagcgg aaactttaca gcgccgtccc cggccgcaag     1200

ttcatcgccg tgaaggcgca cagcccgcag ggtgaaggcg agatcccgct gcaccgcggc     1260

gaggccgtga aggtgctcag cattggggag ggcggtttct gggagggaac cgtgaaaggc     1320

cgcacgggct ggttcccggc cgactgcgtg gaggaagtgc agatgaggca gcatgacaca     1380

cggcctgaaa cgcgggagga ccggacgaag cggctctttc ggcactacac agtgggctcc     1440

tacgacagcc tcacctcaca cagcgattat gtcattgatg acaaagtggc tgtcctgcag     1500

aaacgggacc acgagggctt tggttttgtg ctccggggag ccaaagcaga gacccccatc     1560

gaggagttca cgcccacgcc agccttcccg gcgctgcagt atctcgagtc ggtggacgtg     1620

gagggtgtgg cctggagggc cgggctgcgc acgggagact tcctcatcga ggtgaacggg     1680

gtgaacgtgg tgaaggtcgg acacaagcag gtggtggctc tgattcgcca gggtggcaac     1740

cgcctcgtca tgaaggttgt gtctgtgaca aggaagccag aagaggacgg ggctcggcgc     1800

agagccccac cgccccccaa gagggccccc agcaccacac tgaccctgcg ctccaagtcc     1860

atgacagctg agctcgagga acttgcctcc attcggagct cagaggaaga gccagagctg     1920

gtgtttgctg tgaacctgcc acctgcccag ctgtcgtcca gcgatgagga gaccagggag     1980

gagctggccc gaattgggtt ggtgccaccc cctgaagagt ttgccaacgg ggtcctgctg     2040

gccaccccac tcgctggccc gggcccctcg cccaccacgg tgcccagccc ggcctcaggg     2100

aagcccagca gtgagccacc ccctgcccct gagtctgcag ccgactctgg ggtggaggag     2160

gctgacacac gcagctccag cgacccccac ctggagacca caagcaccat ctccacggtg     2220

tccagcatgt ccaccttgag ctcggagagc ggggaactca ctgacaccca cacctccttc     2280

gctgacggac acacttttct actcgagaag ccaccagtgc ctcccaagcc caagctcaag     2340

tccccgctgg ggaaggggcc ggtgaccttc agggacccgc tgctgaagca gtcctcggac     2400

agcgagctca tggcccagca gcaccacgcc gcctctgccg ggctggcctc tgccgccggg     2460

cctgcccgcc ctcgctacct cttccagaga aggtccaagc tatgggggga ccccgtggag     2520

agccgggggc tccctgggcc tgaagacgac aaaccaactg tgatcagtga gctcagctcc     2580

cgcctgcagc agctgaacaa ggacacgcgt tccctggggg aggaaccagt tggtggcctg     2640

ggcagcctgc tggaccctgc caagaagtcg cccatcgcag cagctcggct cttcagcagc     2700

ctcggtgagc tgagctccat ttcagcgcag cgcagccccg ggggcccggg cggcggggcc     2760

tcgtactcgg tgaggcccag tggccgctac cccgtggcga gacgcgcccc gagcccggtg     2820

aagcccgcgt cgctggagcg ggtggagggg ctgggggcgg gcgcgggggg cgcagggcgg     2880

cccttcggcc tcacgccccc caccatcctc aagtcgtcca gcctctccat cccgcacgag     2940

cccaaggagg tgcgcttcgt ggtgcgcagc gtgagcgcgc gcagtcgctc cccctcgccg     3000

tcgccgctgc cctcgcccgc gtccggcccc ggccccggcg cccccggccc acgccgaccc     3060

ttccagcaga agccgctgca gctctggagc aagttcgacg tgggcgactg gctggagagc     3120

atccacctag gcgagcaccg cgaccgcttc gaggaccatg agatagaagg cgcgcaccta     3180

cccgcgctta ccaaggacga cttcgtggag ctgggcgtca cgcgcgtggg ccaccgcatg     3240

aacatcgagc gcgcgctcag gcagctggac ggcagctga                            3279


<210>  5
<211>  1730
<212>  PRT
<213>  Mus musculus

<400>  5

Met Asp Gly Pro Gly Ala Ser Ala Val Val Val Arg Val Gly Ile Pro 
1               5                   10                  15      


Asp Leu Gln Gln Thr Lys Cys Leu Arg Leu Asp Pro Thr Ala Pro Val 
            20                  25                  30          


Trp Ala Ala Lys Gln Arg Val Leu Cys Ala Leu Asn His Ser Leu Gln 
        35                  40                  45              


Asp Ala Leu Asn Tyr Gly Leu Phe Gln Pro Pro Ser Arg Gly Arg Ala 
    50                  55                  60                  


Gly Lys Phe Leu Asp Glu Glu Arg Leu Leu Gln Asp Tyr Pro Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Pro Leu Pro Tyr Leu Glu Phe Arg Tyr Lys Arg Arg Val 
                85                  90                  95      


Tyr Ala Gln Asn Leu Ile Asp Asp Lys Gln Phe Ala Lys Leu His Thr 
            100                 105                 110         


Lys Ala Asn Leu Lys Lys Phe Met Asp Tyr Val Gln Leu His Ser Thr 
        115                 120                 125             


Asp Lys Val Ala Arg Leu Leu Asp Lys Gly Leu Asp Pro Asn Phe His 
    130                 135                 140                 


Asp Pro Asp Ser Gly Glu Cys Pro Leu Ser Leu Ala Ala Gln Leu Asp 
145                 150                 155                 160 


Asn Ala Thr Asp Leu Leu Lys Val Leu Arg Asn Gly Gly Ala His Leu 
                165                 170                 175     


Asp Phe Arg Thr Arg Asp Gly Leu Thr Ala Val His Cys Ala Thr Arg 
            180                 185                 190         


Gln Arg Asn Ala Gly Ala Leu Thr Thr Leu Leu Asp Leu Gly Ala Ser 
        195                 200                 205             


Pro Asp Tyr Lys Asp Ser Arg Gly Leu Thr Pro Leu Tyr His Ser Ala 
    210                 215                 220                 


Leu Gly Gly Gly Asp Ala Leu Cys Cys Glu Leu Leu Leu His Asp His 
225                 230                 235                 240 


Ala Gln Leu Gly Thr Thr Asp Glu Asn Gly Trp Gln Glu Ile His Gln 
                245                 250                 255     


Ala Cys Arg Phe Gly His Val Gln His Leu Glu His Leu Leu Phe Tyr 
            260                 265                 270         


Gly Ala Asn Met Gly Ala Gln Asn Ala Ser Gly Asn Thr Ala Leu His 
        275                 280                 285             


Ile Cys Ala Leu Tyr Asn Gln Glu Ser Cys Ala Arg Val Leu Leu Phe 
    290                 295                 300                 


Arg Gly Ala Asn Lys Asp Val Arg Asn Tyr Asn Ser Gln Thr Ala Phe 
305                 310                 315                 320 


Gln Val Ala Ile Ile Ala Gly Asn Phe Glu Leu Ala Glu Val Ile Lys 
                325                 330                 335     


Thr His Lys Asp Ser Asp Val Val Pro Phe Arg Glu Thr Pro Ser Tyr 
            340                 345                 350         


Ala Lys Arg Arg Arg Leu Ala Gly Pro Ser Gly Leu Ala Ser Pro Arg 
        355                 360                 365             


Pro Leu Gln Arg Ser Ala Ser Asp Ile Asn Leu Lys Gly Asp Gln Pro 
    370                 375                 380                 


Ala Ala Ser Pro Gly Pro Thr Leu Arg Ser Leu Pro His Gln Leu Leu 
385                 390                 395                 400 


Leu Gln Arg Leu Gln Glu Glu Lys Asp Arg Asp Arg Asp Gly Glu Leu 
                405                 410                 415     


Glu Asn Asp Ile Ser Gly Pro Ser Ala Gly Arg Gly Gly His Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Pro Gly Gly Ser Gly Pro Ala Pro Gly Pro Gly 
        435                 440                 445             


Pro Ala Ser Pro Ala Pro Pro Ala Pro Pro Pro Arg Gly Pro Lys Arg 
    450                 455                 460                 


Lys Leu Tyr Ser Ala Val Pro Gly Arg Lys Phe Ile Ala Val Lys Ala 
465                 470                 475                 480 


His Ser Pro Gln Gly Glu Gly Glu Ile Pro Leu His Arg Gly Glu Ala 
                485                 490                 495     


Val Lys Val Leu Ser Ile Gly Glu Gly Gly Phe Trp Glu Gly Thr Val 
            500                 505                 510         


Lys Gly Arg Thr Gly Trp Phe Pro Ala Asp Cys Val Glu Glu Val Gln 
        515                 520                 525             


Met Arg Gln Tyr Asp Thr Arg His Glu Thr Arg Glu Asp Arg Thr Lys 
    530                 535                 540                 


Arg Leu Phe Arg His Tyr Thr Val Gly Ser Tyr Asp Ser Leu Thr Ser 
545                 550                 555                 560 


His Ser Asp Tyr Val Ile Asp Asp Lys Val Ala Ile Leu Gln Lys Arg 
                565                 570                 575     


Asp His Glu Gly Phe Gly Phe Val Leu Arg Gly Ala Lys Ala Glu Thr 
            580                 585                 590         


Pro Ile Glu Glu Phe Thr Pro Thr Pro Ala Phe Pro Ala Leu Gln Tyr 
        595                 600                 605             


Leu Glu Ser Val Asp Val Glu Gly Val Ala Trp Arg Ala Gly Leu Arg 
    610                 615                 620                 


Thr Gly Asp Phe Leu Ile Glu Val Asn Gly Val Asn Val Val Lys Val 
625                 630                 635                 640 


Gly His Lys Gln Val Val Gly Leu Ile Arg Gln Gly Gly Asn Arg Leu 
                645                 650                 655     


Val Met Lys Val Val Ser Val Thr Arg Lys Pro Glu Glu Asp Gly Ala 
            660                 665                 670         


Arg Arg Arg Ala Pro Pro Pro Pro Lys Arg Ala Pro Ser Thr Thr Leu 
        675                 680                 685             


Thr Leu Arg Ser Lys Ser Met Thr Ala Glu Leu Glu Glu Leu Ala Ser 
    690                 695                 700                 


Ile Arg Arg Arg Lys Gly Glu Lys Leu Asp Glu Ile Leu Ala Val Ala 
705                 710                 715                 720 


Ala Glu Pro Thr Leu Arg Pro Asp Ile Ala Asp Ala Asp Ser Arg Ala 
                725                 730                 735     


Ala Thr Val Lys Gln Arg Pro Thr Ser Arg Arg Ile Thr Pro Ala Glu 
            740                 745                 750         


Ile Ser Ser Leu Phe Glu Arg Gln Gly Leu Pro Gly Pro Glu Lys Leu 
        755                 760                 765             


Pro Gly Ser Leu Arg Lys Gly Ile Pro Arg Thr Lys Ser Val Gly Glu 
    770                 775                 780                 


Asp Glu Lys Leu Ala Ser Leu Leu Glu Gly Arg Phe Pro Arg Ser Thr 
785                 790                 795                 800 


Ser Met Gln Asp Thr Val Arg Glu Gly Arg Gly Ile Pro Pro Pro Pro 
                805                 810                 815     


Gln Thr Ala Pro Pro Pro Pro Pro Ala Pro Tyr Tyr Phe Asp Ser Gly 
            820                 825                 830         


Pro Pro Pro Thr Phe Ser Pro Pro Pro Pro Pro Gly Arg Ala Tyr Asp 
        835                 840                 845             


Thr Val Arg Ser Ser Phe Lys Pro Gly Leu Glu Ala Arg Leu Gly Ala 
    850                 855                 860                 


Gly Ala Ala Gly Leu Tyr Asp Pro Ser Thr Pro Leu Gly Pro Leu Pro 
865                 870                 875                 880 


Tyr Pro Glu Arg Gln Lys Arg Ala Arg Ser Met Ile Ile Leu Gln Asp 
                885                 890                 895     


Ser Ala Pro Glu Val Gly Asp Val Pro Arg Pro Ala Pro Ala Ala Thr 
            900                 905                 910         


Pro Pro Glu Arg Pro Lys Arg Arg Pro Arg Pro Ser Gly Pro Asp Ser 
        915                 920                 925             


Pro Tyr Ala Asn Leu Gly Ala Phe Ser Ala Ser Leu Phe Ala Pro Ser 
    930                 935                 940                 


Lys Pro Gln Arg Arg Lys Ser Pro Leu Val Lys Gln Leu Gln Val Glu 
945                 950                 955                 960 


Asp Ala Gln Glu Arg Ala Ala Leu Ala Val Gly Ser Pro Gly Pro Val 
                965                 970                 975     


Gly Gly Ser Phe Ala Arg Glu Pro Ser Pro Thr His Arg Gly Pro Arg 
            980                 985                 990         


Pro Gly Ser Leu Asp Tyr Ser Ser  Gly Glu Gly Leu Gly  Leu Thr Phe 
        995                 1000                 1005             


Gly Gly  Pro Ser Pro Gly Pro  Val Lys Glu Arg Arg  Leu Glu Glu 
    1010                 1015                 1020             


Arg Arg  Arg Ser Thr Val Phe  Leu Ser Val Gly Ala  Ile Glu Gly 
    1025                 1030                 1035             


Ser Pro  Pro Ser Ala Asp Leu  Pro Ser Leu Gln Pro  Ser Arg Ser 
    1040                 1045                 1050             


Ile Asp  Glu Arg Leu Leu Gly  Thr Gly Ala Thr Thr  Gly Arg Asp 
    1055                 1060                 1065             


Leu Leu  Leu Pro Ser Pro Val  Ser Ala Leu Lys Pro  Leu Val Gly 
    1070                 1075                 1080             


Gly Pro  Ser Leu Gly Pro Ser  Gly Ser Thr Phe Ile  His Pro Leu 
    1085                 1090                 1095             


Thr Gly  Lys Pro Leu Asp Pro  Ser Ser Pro Leu Ala  Leu Ala Leu 
    1100                 1105                 1110             


Ala Ala  Arg Glu Arg Ala Leu  Ala Ser Gln Thr Pro  Ser Arg Ser 
    1115                 1120                 1125             


Pro Thr  Pro Val His Ser Pro  Asp Ala Asp Arg Pro  Gly Pro Leu 
    1130                 1135                 1140             


Phe Val  Asp Val Gln Thr Arg  Asp Ser Glu Arg Gly  Pro Leu Ala 
    1145                 1150                 1155             


Ser Pro  Ala Phe Ser Pro Arg  Ser Pro Ala Trp Ile  Pro Val Pro 
    1160                 1165                 1170             


Ala Arg  Arg Glu Ala Glu Lys  Pro Pro Arg Glu Glu  Arg Lys Ser 
    1175                 1180                 1185             


Pro Glu  Asp Lys Lys Ser Met  Ile Leu Ser Val Leu  Asp Thr Ser 
    1190                 1195                 1200             


Leu Gln  Arg Pro Ala Gly Leu  Ile Val Val His Ala  Thr Ser Asn 
    1205                 1210                 1215             


Gly Gln  Glu Pro Ser Arg Leu  Gly Ala Glu Glu Glu  Arg Pro Gly 
    1220                 1225                 1230             


Thr Pro  Glu Leu Ala Pro Ala  Pro Met Gln Ala Ala  Ala Val Ala 
    1235                 1240                 1245             


Glu Pro  Met Pro Ser Pro Arg  Ala Gln Pro Pro Gly  Ser Ile Pro 
    1250                 1255                 1260             


Ala Asp  Pro Gly Pro Gly Gln  Gly Ser Ser Glu Glu  Glu Pro Glu 
    1265                 1270                 1275             


Leu Val  Phe Ala Val Asn Leu  Pro Pro Ala Gln Leu  Ser Ser Ser 
    1280                 1285                 1290             


Asp Glu  Glu Thr Arg Glu Glu  Leu Ala Arg Ile Gly  Leu Val Pro 
    1295                 1300                 1305             


Pro Pro  Glu Glu Phe Ala Asn  Gly Ile Leu Leu Thr  Thr Pro Pro 
    1310                 1315                 1320             


Pro Gly  Pro Gly Pro Leu Pro  Thr Thr Val Pro Ser  Pro Ala Ser 
    1325                 1330                 1335             


Gly Lys  Pro Ser Ser Glu Leu  Pro Pro Ala Pro Glu  Ser Ala Ala 
    1340                 1345                 1350             


Asp Ser  Gly Val Glu Glu Ala  Asp Thr Arg Ser Ser  Ser Asp Pro 
    1355                 1360                 1365             


His Leu  Glu Thr Thr Ser Thr  Ile Ser Thr Val Ser  Ser Met Ser 
    1370                 1375                 1380             


Thr Leu  Ser Ser Glu Ser Gly  Glu Leu Thr Asp Thr  His Thr Ser 
    1385                 1390                 1395             


Phe Ala  Asp Gly His Thr Phe  Leu Leu Glu Lys Pro  Pro Val Pro 
    1400                 1405                 1410             


Pro Lys  Pro Lys Leu Lys Ser  Pro Leu Gly Lys Gly  Pro Val Thr 
    1415                 1420                 1425             


Phe Arg  Asp Pro Leu Leu Lys  Gln Ser Ser Asp Ser  Glu Leu Met 
    1430                 1435                 1440             


Ala Gln  Gln His His Ala Ala  Ser Thr Gly Leu Ala  Ser Ala Ala 
    1445                 1450                 1455             


Gly Pro  Ala Arg Pro Arg Tyr  Leu Phe Gln Arg Arg  Ser Lys Leu 
    1460                 1465                 1470             


Trp Gly  Asp Pro Val Glu Ser  Arg Gly Leu Pro Gly  Pro Glu Asp 
    1475                 1480                 1485             


Asp Lys  Pro Thr Val Ile Ser  Glu Leu Ser Ser Arg  Leu Gln Gln 
    1490                 1495                 1500             


Leu Asn  Lys Asp Thr Arg Ser  Leu Gly Glu Glu Pro  Val Gly Gly 
    1505                 1510                 1515             


Leu Gly  Ser Leu Leu Asp Pro  Ala Lys Lys Ser Pro  Ile Ala Ala 
    1520                 1525                 1530             


Ala Arg  Leu Phe Ser Ser Leu  Gly Glu Leu Ser Thr  Ile Ser Ala 
    1535                 1540                 1545             


Gln Arg  Ser Pro Gly Gly Pro  Gly Gly Gly Ala Ser  Tyr Ser Val 
    1550                 1555                 1560             


Arg Pro  Ser Gly Arg Tyr Pro  Val Ala Arg Arg Ala  Pro Ser Pro 
    1565                 1570                 1575             


Val Lys  Pro Ala Ser Leu Glu  Arg Val Glu Gly Leu  Gly Ala Gly 
    1580                 1585                 1590             


Val Gly  Gly Ala Gly Arg Pro  Phe Gly Leu Thr Pro  Pro Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Ser Ser Leu Ser  Ile Pro His Glu Pro  Lys Glu Val 
    1610                 1615                 1620             


Arg Phe  Val Val Arg Ser Val  Ser Ala Arg Ser Arg  Ser Pro Ser 
    1625                 1630                 1635             


Pro Ser  Pro Leu Pro Ser Pro  Ser Pro Gly Ser Gly  Pro Ser Ala 
    1640                 1645                 1650             


Gly Pro  Arg Arg Pro Phe Gln  Gln Lys Pro Leu Gln  Leu Trp Ser 
    1655                 1660                 1665             


Lys Phe  Asp Val Gly Asp Trp  Leu Glu Ser Ile His  Leu Gly Glu 
    1670                 1675                 1680             


His Arg  Asp Arg Phe Glu Asp  His Glu Ile Glu Gly  Ala His Leu 
    1685                 1690                 1695             


Pro Ala  Leu Thr Lys Glu Asp  Phe Val Glu Leu Gly  Val Thr Arg 
    1700                 1705                 1710             


Val Gly  His Arg Met Asn Ile  Glu Arg Ala Leu Arg  Gln Leu Asp 
    1715                 1720                 1725             


Gly Ser  
    1730 


<210>  6
<211>  1731
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Gly Pro Gly Ala Ser Ala Val Val Val Arg Val Gly Ile Pro 
1               5                   10                  15      


Asp Leu Gln Gln Thr Lys Cys Leu Arg Leu Asp Pro Ala Ala Pro Val 
            20                  25                  30          


Trp Ala Ala Lys Gln Arg Val Leu Cys Ala Leu Asn His Ser Leu Gln 
        35                  40                  45              


Asp Ala Leu Asn Tyr Gly Leu Phe Gln Pro Pro Ser Arg Gly Arg Ala 
    50                  55                  60                  


Gly Lys Phe Leu Asp Glu Glu Arg Leu Leu Gln Glu Tyr Pro Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Pro Leu Pro Tyr Leu Glu Phe Arg Tyr Lys Arg Arg Val 
                85                  90                  95      


Tyr Ala Gln Asn Leu Ile Asp Asp Lys Gln Phe Ala Lys Leu His Thr 
            100                 105                 110         


Lys Ala Asn Leu Lys Lys Phe Met Asp Tyr Val Gln Leu His Ser Thr 
        115                 120                 125             


Asp Lys Val Ala Arg Leu Leu Asp Lys Gly Leu Asp Pro Asn Phe His 
    130                 135                 140                 


Asp Pro Asp Ser Gly Glu Cys Pro Leu Ser Leu Ala Ala Gln Leu Asp 
145                 150                 155                 160 


Asn Ala Thr Asp Leu Leu Lys Val Leu Lys Asn Gly Gly Ala His Leu 
                165                 170                 175     


Asp Phe Arg Thr Arg Asp Gly Leu Thr Ala Val His Cys Ala Thr Arg 
            180                 185                 190         


Gln Arg Asn Ala Ala Ala Leu Thr Thr Leu Leu Asp Leu Gly Ala Ser 
        195                 200                 205             


Pro Asp Tyr Lys Asp Ser Arg Gly Leu Thr Pro Leu Tyr His Ser Ala 
    210                 215                 220                 


Leu Gly Gly Gly Asp Ala Leu Cys Cys Glu Leu Leu Leu His Asp His 
225                 230                 235                 240 


Ala Gln Leu Gly Ile Thr Asp Glu Asn Gly Trp Gln Glu Ile His Gln 
                245                 250                 255     


Ala Cys Arg Phe Gly His Val Gln His Leu Glu His Leu Leu Phe Tyr 
            260                 265                 270         


Gly Ala Asp Met Gly Ala Gln Asn Ala Ser Gly Asn Thr Ala Leu His 
        275                 280                 285             


Ile Cys Ala Leu Tyr Asn Gln Glu Ser Cys Ala Arg Val Leu Leu Phe 
    290                 295                 300                 


Arg Gly Ala Asn Arg Asp Val Arg Asn Tyr Asn Ser Gln Thr Ala Phe 
305                 310                 315                 320 


Gln Val Ala Ile Ile Ala Gly Asn Phe Glu Leu Ala Glu Val Ile Lys 
                325                 330                 335     


Thr His Lys Asp Ser Asp Val Val Pro Phe Arg Glu Thr Pro Ser Tyr 
            340                 345                 350         


Ala Lys Arg Arg Arg Leu Ala Gly Pro Ser Gly Leu Ala Ser Pro Arg 
        355                 360                 365             


Pro Leu Gln Arg Ser Ala Ser Asp Ile Asn Leu Lys Gly Glu Ala Gln 
    370                 375                 380                 


Pro Ala Ala Ser Pro Gly Pro Ser Leu Arg Ser Leu Pro His Gln Leu 
385                 390                 395                 400 


Leu Leu Gln Arg Leu Gln Glu Glu Lys Asp Arg Asp Arg Asp Ala Asp 
                405                 410                 415     


Gln Glu Ser Asn Ile Ser Gly Pro Leu Ala Gly Arg Ala Gly Gln Ser 
            420                 425                 430         


Lys Ile Ser Pro Ser Gly Pro Gly Gly Pro Gly Pro Ala Pro Gly Pro 
        435                 440                 445             


Gly Pro Ala Pro Pro Ala Pro Pro Ala Pro Pro Pro Arg Gly Pro Lys 
    450                 455                 460                 


Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Lys Phe Ile Ala Val Lys 
465                 470                 475                 480 


Ala His Ser Pro Gln Gly Glu Gly Glu Ile Pro Leu His Arg Gly Glu 
                485                 490                 495     


Ala Val Lys Val Leu Ser Ile Gly Glu Gly Gly Phe Trp Glu Gly Thr 
            500                 505                 510         


Val Lys Gly Arg Thr Gly Trp Phe Pro Ala Asp Cys Val Glu Glu Val 
        515                 520                 525             


Gln Met Arg Gln His Asp Thr Arg Pro Glu Thr Arg Glu Asp Arg Thr 
    530                 535                 540                 


Lys Arg Leu Phe Arg His Tyr Thr Val Gly Ser Tyr Asp Ser Leu Thr 
545                 550                 555                 560 


Ser His Ser Asp Tyr Val Ile Asp Asp Lys Val Ala Val Leu Gln Lys 
                565                 570                 575     


Arg Asp His Glu Gly Phe Gly Phe Val Leu Arg Gly Ala Lys Ala Glu 
            580                 585                 590         


Thr Pro Ile Glu Glu Phe Thr Pro Thr Pro Ala Phe Pro Ala Leu Gln 
        595                 600                 605             


Tyr Leu Glu Ser Val Asp Val Glu Gly Val Ala Trp Arg Ala Gly Leu 
    610                 615                 620                 


Arg Thr Gly Asp Phe Leu Ile Glu Val Asn Gly Val Asn Val Val Lys 
625                 630                 635                 640 


Val Gly His Lys Gln Val Val Ala Leu Ile Arg Gln Gly Gly Asn Arg 
                645                 650                 655     


Leu Val Met Lys Val Val Ser Val Thr Arg Lys Pro Glu Glu Asp Gly 
            660                 665                 670         


Ala Arg Arg Arg Ala Pro Pro Pro Pro Lys Arg Ala Pro Ser Thr Thr 
        675                 680                 685             


Leu Thr Leu Arg Ser Lys Ser Met Thr Ala Glu Leu Glu Glu Leu Ala 
    690                 695                 700                 


Ser Ile Arg Arg Arg Lys Gly Glu Lys Leu Asp Glu Met Leu Ala Ala 
705                 710                 715                 720 


Ala Ala Glu Pro Thr Leu Arg Pro Asp Ile Ala Asp Ala Asp Ser Arg 
                725                 730                 735     


Ala Ala Thr Val Lys Gln Arg Pro Thr Ser Arg Arg Ile Thr Pro Ala 
            740                 745                 750         


Glu Ile Ser Ser Leu Phe Glu Arg Gln Gly Leu Pro Gly Pro Glu Lys 
        755                 760                 765             


Leu Pro Gly Ser Leu Arg Lys Gly Ile Pro Arg Thr Lys Ser Val Gly 
    770                 775                 780                 


Glu Asp Glu Lys Leu Ala Ser Leu Leu Glu Gly Arg Phe Pro Arg Ser 
785                 790                 795                 800 


Thr Ser Met Gln Asp Pro Val Arg Glu Gly Arg Gly Ile Pro Pro Pro 
                805                 810                 815     


Pro Gln Thr Ala Pro Pro Pro Pro Pro Ala Pro Tyr Tyr Phe Asp Ser 
            820                 825                 830         


Gly Pro Pro Pro Ala Phe Ser Pro Pro Pro Pro Pro Gly Arg Ala Tyr 
        835                 840                 845             


Asp Thr Val Arg Ser Ser Phe Lys Pro Gly Leu Glu Ala Arg Leu Gly 
    850                 855                 860                 


Ala Gly Ala Ala Gly Leu Tyr Glu Pro Gly Ala Ala Leu Gly Pro Leu 
865                 870                 875                 880 


Pro Tyr Pro Glu Arg Gln Lys Arg Ala Arg Ser Met Ile Ile Leu Gln 
                885                 890                 895     


Asp Ser Ala Pro Glu Ser Gly Asp Ala Pro Arg Pro Pro Pro Ala Ala 
            900                 905                 910         


Thr Pro Pro Glu Arg Pro Lys Arg Arg Pro Arg Pro Pro Gly Pro Asp 
        915                 920                 925             


Ser Pro Tyr Ala Asn Leu Gly Ala Phe Ser Ala Ser Leu Phe Ala Pro 
    930                 935                 940                 


Ser Lys Pro Gln Arg Arg Lys Ser Pro Leu Val Lys Gln Leu Gln Val 
945                 950                 955                 960 


Glu Asp Ala Gln Glu Arg Ala Ala Leu Ala Val Gly Ser Pro Gly Pro 
                965                 970                 975     


Gly Gly Gly Ser Phe Ala Arg Glu Pro Ser Pro Thr His Arg Gly Pro 
            980                 985                 990         


Arg Pro Gly Gly Leu Asp Tyr Gly  Ala Gly Asp Gly Pro  Gly Leu Ala 
        995                 1000                 1005             


Phe Gly  Gly Pro Gly Pro Ala  Lys Asp Arg Arg Leu  Glu Glu Arg 
    1010                 1015                 1020             


Arg Arg  Ser Thr Val Phe Leu  Ser Val Gly Ala Ile  Glu Gly Ser 
    1025                 1030                 1035             


Ala Pro  Gly Ala Asp Leu Pro  Ser Leu Gln Pro Ser  Arg Ser Ile 
    1040                 1045                 1050             


Asp Glu  Arg Leu Leu Gly Thr  Gly Pro Thr Ala Gly  Arg Asp Leu 
    1055                 1060                 1065             


Leu Leu  Pro Ser Pro Val Ser  Ala Leu Lys Pro Leu  Val Ser Gly 
    1070                 1075                 1080             


Pro Ser  Leu Gly Pro Ser Gly  Ser Thr Phe Ile His  Pro Leu Thr 
    1085                 1090                 1095             


Gly Lys  Pro Leu Asp Pro Ser  Ser Pro Leu Ala Leu  Ala Leu Ala 
    1100                 1105                 1110             


Ala Arg  Glu Arg Ala Leu Ala  Ser Gln Ala Pro Ser  Arg Ser Pro 
    1115                 1120                 1125             


Thr Pro  Val His Ser Pro Asp  Ala Asp Arg Pro Gly  Pro Leu Phe 
    1130                 1135                 1140             


Val Asp  Val Gln Ala Arg Asp  Pro Glu Arg Gly Ser  Leu Ala Ser 
    1145                 1150                 1155             


Pro Ala  Phe Ser Pro Arg Ser  Pro Ala Trp Ile Pro  Val Pro Ala 
    1160                 1165                 1170             


Arg Arg  Glu Ala Glu Lys Val  Pro Arg Glu Glu Arg  Lys Ser Pro 
    1175                 1180                 1185             


Glu Asp  Lys Lys Ser Met Ile  Leu Ser Val Leu Asp  Thr Ser Leu 
    1190                 1195                 1200             


Gln Arg  Pro Ala Gly Leu Ile  Val Val His Ala Thr  Ser Asn Gly 
    1205                 1210                 1215             


Gln Glu  Pro Ser Arg Leu Gly  Gly Ala Glu Glu Glu  Arg Pro Gly 
    1220                 1225                 1230             


Thr Pro  Glu Leu Ala Pro Ala  Pro Met Gln Ser Ala  Ala Val Ala 
    1235                 1240                 1245             


Glu Pro  Leu Pro Ser Pro Arg  Ala Gln Pro Pro Gly  Gly Thr Pro 
    1250                 1255                 1260             


Ala Asp  Ala Gly Pro Gly Gln  Gly Ser Ser Glu Glu  Glu Pro Glu 
    1265                 1270                 1275             


Leu Val  Phe Ala Val Asn Leu  Pro Pro Ala Gln Leu  Ser Ser Ser 
    1280                 1285                 1290             


Asp Glu  Glu Thr Arg Glu Glu  Leu Ala Arg Ile Gly  Leu Val Pro 
    1295                 1300                 1305             


Pro Pro  Glu Glu Phe Ala Asn  Gly Val Leu Leu Ala  Thr Pro Leu 
    1310                 1315                 1320             


Ala Gly  Pro Gly Pro Ser Pro  Thr Thr Val Pro Ser  Pro Ala Ser 
    1325                 1330                 1335             


Gly Lys  Pro Ser Ser Glu Pro  Pro Pro Ala Pro Glu  Ser Ala Ala 
    1340                 1345                 1350             


Asp Ser  Gly Val Glu Glu Ala  Asp Thr Arg Ser Ser  Ser Asp Pro 
    1355                 1360                 1365             


His Leu  Glu Thr Thr Ser Thr  Ile Ser Thr Val Ser  Ser Met Ser 
    1370                 1375                 1380             


Thr Leu  Ser Ser Glu Ser Gly  Glu Leu Thr Asp Thr  His Thr Ser 
    1385                 1390                 1395             


Phe Ala  Asp Gly His Thr Phe  Leu Leu Glu Lys Pro  Pro Val Pro 
    1400                 1405                 1410             


Pro Lys  Pro Lys Leu Lys Ser  Pro Leu Gly Lys Gly  Pro Val Thr 
    1415                 1420                 1425             


Phe Arg  Asp Pro Leu Leu Lys  Gln Ser Ser Asp Ser  Glu Leu Met 
    1430                 1435                 1440             


Ala Gln  Gln His His Ala Ala  Ser Ala Gly Leu Ala  Ser Ala Ala 
    1445                 1450                 1455             


Gly Pro  Ala Arg Pro Arg Tyr  Leu Phe Gln Arg Arg  Ser Lys Leu 
    1460                 1465                 1470             


Trp Gly  Asp Pro Val Glu Ser  Arg Gly Leu Pro Gly  Pro Glu Asp 
    1475                 1480                 1485             


Asp Lys  Pro Thr Val Ile Ser  Glu Leu Ser Ser Arg  Leu Gln Gln 
    1490                 1495                 1500             


Leu Asn  Lys Asp Thr Arg Ser  Leu Gly Glu Glu Pro  Val Gly Gly 
    1505                 1510                 1515             


Leu Gly  Ser Leu Leu Asp Pro  Ala Lys Lys Ser Pro  Ile Ala Ala 
    1520                 1525                 1530             


Ala Arg  Leu Phe Ser Ser Leu  Gly Glu Leu Ser Ser  Ile Ser Ala 
    1535                 1540                 1545             


Gln Arg  Ser Pro Gly Gly Pro  Gly Gly Gly Ala Ser  Tyr Ser Val 
    1550                 1555                 1560             


Arg Pro  Ser Gly Arg Tyr Pro  Val Ala Arg Arg Ala  Pro Ser Pro 
    1565                 1570                 1575             


Val Lys  Pro Ala Ser Leu Glu  Arg Val Glu Gly Leu  Gly Ala Gly 
    1580                 1585                 1590             


Ala Gly  Gly Ala Gly Arg Pro  Phe Gly Leu Thr Pro  Pro Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Ser Ser Leu Ser  Ile Pro His Glu Pro  Lys Glu Val 
    1610                 1615                 1620             


Arg Phe  Val Val Arg Ser Val  Ser Ala Arg Ser Arg  Ser Pro Ser 
    1625                 1630                 1635             


Pro Ser  Pro Leu Pro Ser Pro  Ala Ser Gly Pro Gly  Pro Gly Ala 
    1640                 1645                 1650             


Pro Gly  Pro Arg Arg Pro Phe  Gln Gln Lys Pro Leu  Gln Leu Trp 
    1655                 1660                 1665             


Ser Lys  Phe Asp Val Gly Asp  Trp Leu Glu Ser Ile  His Leu Gly 
    1670                 1675                 1680             


Glu His  Arg Asp Arg Phe Glu  Asp His Glu Ile Glu  Gly Ala His 
    1685                 1690                 1695             


Leu Pro  Ala Leu Thr Lys Asp  Asp Phe Val Glu Leu  Gly Val Thr 
    1700                 1705                 1710             


Arg Val  Gly His Arg Met Asn  Ile Glu Arg Ala Leu  Arg Gln Leu 
    1715                 1720                 1725             


Asp Gly  Ser 
    1730     


<210>  7
<211>  7459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtttaat taagtgtcta gactgcagag      180

ggccctgcgt atgagtgcaa gtgggtttta ggaccaggat gaggcggggt gggggtgcct      240

acctgacgac cgaccccgac ccactggaca agcacccaac ccccattccc caaattgcgc      300

atcccctatc agagaggggg aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag      360

cttcagcacc gcggacagtg ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca      420

gcactgaagg cgcgctgacg tcactcgccg gtcccccgca aactcccctt cccggccacc      480

ttggtcgcgt ccgcgccgcc gccggcccag ccggaccgca ccacgcgagg cgcgagatag      540

gggggcacgg gcgcgaccat ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg      600

cggtgggcag cggaggagtc gtgtcgtgcc tgagagcgca gtcgagaaac cggctagagg      660

atccttcgaa accggtgcta gcagcgctgt taacaccatg gtgagcaagg gcgaggagct      720

gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt      780

cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat      840

ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg      900

cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc      960

catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa     1020

gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg     1080

catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag     1140

ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat     1200

ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc     1260

catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct     1320

gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc     1380

cgggatcact ctcggcatgg acgagctgta caagggaagc ggaggaattc acggcccgaa     1440

gcggaaactt tacagtgccg tccccggccg caagttcatc gctgtgaagg cgcacagccc     1500

gcagggcgag ggcgagatcc cgctgcaccg cggcgaggcc gtgaaggtgc tcagcattgg     1560

ggagggcggt ttctgggagg gaaccgtgaa gggccgaaca ggctggttcc cagctgactg     1620

tgtggaagaa gtgcagatgc gacagtatga cacccggcat gaaaccagag aggaccggac     1680

gaagcgtctc ttccgccact acactgtggg ttcctatgac agcctcactt cacacagcga     1740

ttatgtcatc gatgataagg tggctatcct gcagaaaagg gaccatgagg ggtttggctt     1800

tgttctccgg ggagccaaag cagagacccc cattgaggag tttacaccca cacctgcctt     1860

ccctgcactc caataccttg agtctgtaga tgtggaaggt gtggcctgga gggctggact     1920

tcgaactggg gacttcctca ttgaggtgaa cggagtgaat gtcgtgaagg ttggacacaa     1980

gcaagtggtg ggtctcatcc gtcagggtgg caaccgcctg gtcatgaagg ttgtgtctgt     2040

gaccaggaaa cccgaggagg atggtgctcg gcgcagagcc ccaccacccc caaagagggc     2100

tcccagcacc acgctgaccc tgcggtccaa gtccatgacg gctgagctcg aggaacttgc     2160

ttccattcgg agctcagagg aggagccaga gctggtattc gctgtgaacc tgccacctgc     2220

tcagctgtcc tccagcgatg aggagaccag agaggagctg gcccgcatag ggctagtgcc     2280

accccctgaa gagtttgcca atgggatcct gctgaccacc ccgcccccag ggccgggccc     2340

cttgcccacc acggtaccca gcccggcctc agggaagccc agcagcgagc tgccccctgc     2400

ccctgagtct gcagctgact ctggagtaga ggaggctgac actcgaagct ccagtgaccc     2460

ccacctggag accacaagca ccatttccac agtgtccagc atgtccaccc tgagctcgga     2520

gagtggggaa ctcacggaca cccacacctc ctttgccgat ggacacactt ttctactcga     2580

gaagccacca gtgcctccca agcccaagct caagtccccg ctggggaagg ggccggtgac     2640

cttcagggac ccgctgctga agcaatcctc ggacagtgag ctcatggccc agcagcacca     2700

tgctgcctct actgggttgg cttctgctgc tgggcccgcc cgccctcgct acctcttcca     2760

gagaaggtcc aagctgtggg gggaccccgt ggagagtcgg gggctccctg ggcctgaaga     2820

tgacaaacca actgtgatca gtgagctcag ctcccgtctg cagcagctga ataaagacac     2880

acgctccttg ggggaggaac cagttggtgg cctgggcagc ctgctggacc ctgctaagaa     2940

gtcacccatt gcagcagctc ggctcttcag cagcctcggt gagctgagca ccatctcagc     3000

gcagcgcagc ccggggggcc cgggcggagg ggcctcctac tcggtgcggc ccagcggccg     3060

gtaccccgtg gcgagacgag ccccgagccc agtgaaaccc gcatcgctgg agcgggtgga     3120

ggggctgggg gcgggcgtgg gaggcgcggg gcggcccttc ggcctcacgc ctcccaccat     3180

cctcaagtcg tccagcctct ccatcccgca cgaacccaag gaagtgcgct tcgtggtgcg     3240

aagtgtgagt gcgcgcagcc gctccccctc accatctccg ctgccctcgc cttctcccgg     3300

ctctggcccc agtgccggcc cgcgtcggcc atttcaacag aagcccctgc agctctggag     3360

caagttcgat gtgggcgact ggctggagag catccactta ggcgagcacc gagaccgctt     3420

cgaggaccat gagatcgaag gcgcacacct gcctgcgctc accaaggaag acttcgtgga     3480

gctgggcgtc acacgcgttg gccaccgcat gaacatcgag cgtgcgctca ggcagctgga     3540

tggcagctga gcggccatcg tcgacggcgc gccaagctta tcgataatca acctctggat     3600

tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt     3660

ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc     3720

tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg     3780

caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc     3840

accacctgtc agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa     3900

ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat     3960

tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc tgctcgccta tgttgccacc     4020

tggattctgc gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt     4080

ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag     4140

acgagtcgga tctccctttg ggccgcctcc ccgcatcgat accgagcgct gctcgagaga     4200

tctacgggtg gcatccctgt gacccctccc cagtgcctct cctggccctg gaagttgcca     4260

ctccagtgcc caccagcctt gtcctaataa aattaagttg catcattttg tctgactagg     4320

tgtccttcta taatattatg gggtggaggg gggtggtatg gagcaagggg caagttggga     4380

agacaacctg tagggcctgc ggggtctatt gggaaccaag ctggagtgca gtggcacaat     4440

cttggctcac tgcaatctcc gcctcctggg ttcaagcgat tctcctgcct cagcctcccg     4500

agttgttggg attccaggca tgcatgacca ggctcagcta atttttgttt ttttggtaga     4560

gacggggttt caccatattg gccaggctgg tctccaactc ctaatctcag gtgatctacc     4620

caccttggcc tcccaaattg ctgggattac aggcgtgaac cactgctccc ttccctgtcc     4680

ttctgatttt gtaggtaacc acgtgcggac cgagcggccg caggaacccc tagtgatgga     4740

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4800

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca     4860

ggggcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatacg     4920

tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     4980

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     5040

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     5100

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga tttgggtgat     5160

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     5220

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcgggc     5280

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     5340

atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat tttatggtgc     5400

actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca     5460

cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg     5520

accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga     5580

cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct     5640

tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc     5700

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa     5760

tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt     5820

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct     5880

gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc     5940

cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta     6000

tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac     6060

tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc     6120

atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac     6180

ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg     6240

gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac     6300

gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc     6360

gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt     6420

gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga     6480

gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc     6540

cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag     6600

atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca     6660

tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc     6720

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca     6780

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc     6840

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta     6900

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt     6960

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc     7020

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg     7080

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg     7140

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag     7200

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc     7260

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat     7320

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg     7380

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc     7440

tggccttttg ctcacatgt                                                  7459


<210>  8
<211>  5331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtttaat taagtgtcta gactgcagag      180

ggccctgcgt atgagtgcaa gtgggtttta ggaccaggat gaggcggggt gggggtgcct      240

acctgacgac cgaccccgac ccactggaca agcacccaac ccccattccc caaattgcgc      300

atcccctatc agagaggggg aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag      360

cttcagcacc gcggacagtg ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca      420

gcactgaagg cgcgctgacg tcactcgccg gtcccccgca aactcccctt cccggccacc      480

ttggtcgcgt ccgcgccgcc gccggcccag ccggaccgca ccacgcgagg cgcgagatag      540

gggggcacgg gcgcgaccat ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg      600

cggtgggcag cggaggagtc gtgtcgtgcc tgagagcgca gtcgagaaac cggctagagg      660

atccttcgaa accggtgcta gcagcgctgt taacaccatg gtgagcaagg gcgaggagct      720

gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt      780

cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat      840

ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg      900

cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc      960

catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa     1020

gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg     1080

catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag     1140

ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat     1200

ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc     1260

catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct     1320

gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc     1380

cgggatcact ctcggcatgg acgagctgta caagtaaggc gcgcccctgc agggaattcg     1440

atatcaagct tatcgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta     1500

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc     1560

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt     1620

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg     1680

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt     1740

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct     1800

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt     1860

cctttccttg gctgctcgcc tatgttgcca cctggattct gcgcgggacg tccttctgct     1920

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc     1980

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct     2040

ccccgcatcg ataccgagcg ctgctcgaga gatctacggg tggcatccct gtgacccctc     2100

cccagtgcct ctcctggccc tggaagttgc cactccagtg cccaccagcc ttgtcctaat     2160

aaaattaagt tgcatcattt tgtctgacta ggtgtccttc tataatatta tggggtggag     2220

gggggtggta tggagcaagg ggcaagttgg gaagacaacc tgtagggcct gcggggtcta     2280

ttgggaacca agctggagtg cagtggcaca atcttggctc actgcaatct ccgcctcctg     2340

ggttcaagcg attctcctgc ctcagcctcc cgagttgttg ggattccagg catgcatgac     2400

caggctcagc taatttttgt ttttttggta gagacggggt ttcaccatat tggccaggct     2460

ggtctccaac tcctaatctc aggtgatcta cccaccttgg cctcccaaat tgctgggatt     2520

acaggcgtga accactgctc ccttccctgt ccttctgatt ttgtaggtaa ccacgtgcgg     2580

accgagcggc cgcaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     2640

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     2700

tcagtgagcg agcgagcgcg cagctgcctg caggggcgcc tgatgcggta ttttctcctt     2760

acgcatctgt gcggtatttc acaccgcata cgtcaaagca accatagtac gcgccctgta     2820

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     2880

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     2940

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     3000

acctcgaccc caaaaaactt gatttgggtg atggttcacg tagtgggcca tcgccctgat     3060

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     3120

aaactggaac aacactcaac cctatctcgg gctattcttt tgatttataa gggattttgc     3180

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta     3240

acaaaatatt aacgtttaca attttatggt gcactctcag tacaatctgc tctgatgccg     3300

catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc     3360

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     3420

ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt     3480

tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa     3540

atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca     3600

tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc     3660

aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc     3720

acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt     3780

acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt     3840

ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg     3900

ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact     3960

caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg     4020

ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga     4080

aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg     4140

aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa     4200

tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac     4260

aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc     4320

cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca     4380

ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga     4440

gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta     4500

agcattggta actgtcagac caagtttact catatatact ttagattgat ttaaaacttc     4560

atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc     4620

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt     4680

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac     4740

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct     4800

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact     4860

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg     4920

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata     4980

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga     5040

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag     5100

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg     5160

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac     5220

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca     5280

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg t              5331


<210>  9
<211>  6369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtttaat taagtgtcta gactgcagag      180

ggccctgcgt atgagtgcaa gtgggtttta ggaccaggat gaggcggggt gggggtgcct      240

acctgacgac cgaccccgac ccactggaca agcacccaac ccccattccc caaattgcgc      300

atcccctatc agagaggggg aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag      360

cttcagcacc gcggacagtg ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca      420

gcactgaagg cgcgctgacg tcactcgccg gtcccccgca aactcccctt cccggccacc      480

ttggtcgcgt ccgcgccgcc gccggcccag ccggaccgca ccacgcgagg cgcgagatag      540

gggggcacgg gcgcgaccat ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg      600

cggtgggcag cggaggagtc gtgtcgtgcc tgagagcgca gtcgagaaac cggctagagg      660

atccttcgaa accggtgcta gcaccatgcc taagaagaag agaaaggtat gcaggtcaca      720

ccaaaatttg cctgcattac cggtcgatgc aacgagtgat gaggttcgca agaacctgat      780

ggacatgttc agggatcgcc aggcgttttc tgagcatacc tggaaaatgc ttctgtccgt      840

ttgccggtcg tgggcggcat ggtgcaagtt gaataaccgg aaatggtttc ccgcagaacc      900

tgaagatgtt cgcgattatc ttctatatct tcaggcgcgc ggtctggcag taaaaactat      960

ccagcaacat ttgggccagc taaacatgct tcatcgtcgg tccgggctgc cacgaccaag     1020

tgacagcaat gctgtttcac tggttatgcg gcggatccga aaagaaaacg ttgatgccgg     1080

tgaacgtgca aaacaggctc tagcgttcga acgcactgat ttcgaccagg ttcgttcact     1140

catggaaaat agcgatcgct gccaggatat acgtaatctg gcatttctgg ggattgctta     1200

taacaccctg ttacgtatag ccgaaattgc caggatcagg gttaaagata tctcacgtac     1260

tgacggtggg agaatgttaa tccatattgg cagaacgaaa acgctggtta gcaccgcagg     1320

tgtagagaag gcacttagcc tgggggtaac taaactggtc gagcgatgga tttccgtctc     1380

tggtgtagct gatgatccga ataactacct gttttgccgg gtcagaaaaa atggtgttgc     1440

cgcgccatct gccaccagcc agctatcaac tcgcgccctg gaagggattt ttgaagcaac     1500

tcatcgattg atttacggcg ctaaggatga ctctggtcag agatacctgg cctggtctgg     1560

acacagtgcc cgtgtcggag ccgcgcgaga tatggcccgc gctggagttt caataccgga     1620

gatcatgcaa gctggtggct ggaccaatgt aaatattgtc atgaactata tccgtaacct     1680

ggatagtgaa acaggggcaa tggtgcgcct gctggaagat ggcgatgtta acgtgagcaa     1740

gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa     1800

cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac     1860

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac     1920

cctgacctac ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt     1980

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga     2040

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat     2100

cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta     2160

caactacaac agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt     2220

gaacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca     2280

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac     2340

ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt     2400

cgtgaccgcc gccgggatca ctctcggcat ggacgagctg tacaagtaag tcgacggcgc     2460

gcccctgcag ggaattcgat atcaagctta tcgataatca acctctggat tacaaaattt     2520

gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg     2580

ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt     2640

ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg     2700

tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc     2760

agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg     2820

cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt     2880

tgtcggggaa atcatcgtcc tttccttggc tgctcgccta tgttgccacc tggattctgc     2940

gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg     3000

gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga     3060

tctccctttg ggccgcctcc ccgcatcgat accgagcgct gctcgagaga tctacgggtg     3120

gcatccctgt gacccctccc cagtgcctct cctggccctg gaagttgcca ctccagtgcc     3180

caccagcctt gtcctaataa aattaagttg catcattttg tctgactagg tgtccttcta     3240

taatattatg gggtggaggg gggtggtatg gagcaagggg caagttggga agacaacctg     3300

tagggcctgc ggggtctatt gggaaccaag ctggagtgca gtggcacaat cttggctcac     3360

tgcaatctcc gcctcctggg ttcaagcgat tctcctgcct cagcctcccg agttgttggg     3420

attccaggca tgcatgacca ggctcagcta atttttgttt ttttggtaga gacggggttt     3480

caccatattg gccaggctgg tctccaactc ctaatctcag gtgatctacc caccttggcc     3540

tcccaaattg ctgggattac aggcgtgaac cactgctccc ttccctgtcc ttctgatttt     3600

gtaggtaacc acgtgcggac cgagcggccg caggaacccc tagtgatgga gttggccact     3660

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     3720

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg     3780

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatacg tcaaagcaac     3840

catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     3900

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     3960

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     4020

gatttagtgc tttacggcac ctcgacccca aaaaacttga tttgggtgat ggttcacgta     4080

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     4140

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcgggc tattcttttg     4200

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     4260

aatttaacgc gaattttaac aaaatattaa cgtttacaat tttatggtgc actctcagta     4320

caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg     4380

cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg     4440

ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc     4500

tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag     4560

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     4620

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa     4680

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt     4740

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt     4800

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt     4860

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg     4920

tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga     4980

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa     5040

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga     5100

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa     5160

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca     5220

ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta     5280

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac     5340

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc     5400

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag     5460

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga     5520

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt     5580

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata     5640

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     5700

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     5760

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     5820

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc     5880

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     5940

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     6000

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     6060

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     6120

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     6180

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     6240

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     6300

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     6360

ctcacatgt                                                             6369


<210>  10
<211>  5703
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtttaat taagtgtcta gactgcagag      180

ggccctgcgt atgagtgcaa gtgggtttta ggaccaggat gaggcggggt gggggtgcct      240

acctgacgac cgaccccgac ccactggaca agcacccaac ccccattccc caaattgcgc      300

atcccctatc agagaggggg aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag      360

cttcagcacc gcggacagtg ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca      420

gcactgaagg cgcgctgacg tcactcgccg gtcccccgca aactcccctt cccggccacc      480

ttggtcgcgt ccgcgccgcc gccggcccag ccggaccgca ccacgcgagg cgcgagatag      540

gggggcacgg gcgcgaccat ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg      600

cggtgggcag cggaggagtc gtgtcgtgcc tgagagcgca gtcgagaaac cggctagagg      660

atccttcgaa accggtgcta gcaccatgcc taagaagaag agaaaggtat gcaggtcaca      720

ccaaaatttg cctgcattac cggtcgatgc aacgagtgat gaggttcgca agaacctgat      780

ggacatgttc agggatcgcc aggcgttttc tgagcatacc tggaaaatgc ttctgtccgt      840

ttgccggtcg tgggcggcat ggtgcaagtt gaataaccgg aaatggtttc ccgcagaacc      900

tgaagatgtt cgcgattatc ttctatatct tcaggcgcgc ggtctggcag taaaaactat      960

ccagcaacat ttgggccagc taaacatgct tcatcgtcgg tccgggctgc cacgaccaag     1020

tgacagcaat gctgtttcac tggttatgcg gcggatccga gttaacgtga gcaagggcga     1080

ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca     1140

caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa     1200

gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac     1260

ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa     1320

gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa     1380

ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct     1440

gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta     1500

caacagccac aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt     1560

caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa     1620

cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc     1680

cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac     1740

cgccgccggg atcactctcg gcatggacga gctgtacaag taagtcgacg gcgcgcccct     1800

gcagggaatt cgatatcaag cttatcgata atcaacctct ggattacaaa atttgtgaaa     1860

gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa     1920

tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat     1980

cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt     2040

gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc     2100

tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc     2160

ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg     2220

ggaaatcatc gtcctttcct tggctgctcg cctatgttgc cacctggatt ctgcgcggga     2280

cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc     2340

tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt cggatctccc     2400

tttgggccgc ctccccgcat cgataccgag cgctgctcga gagatctacg ggtggcatcc     2460

ctgtgacccc tccccagtgc ctctcctggc cctggaagtt gccactccag tgcccaccag     2520

ccttgtccta ataaaattaa gttgcatcat tttgtctgac taggtgtcct tctataatat     2580

tatggggtgg aggggggtgg tatggagcaa ggggcaagtt gggaagacaa cctgtagggc     2640

ctgcggggtc tattgggaac caagctggag tgcagtggca caatcttggc tcactgcaat     2700

ctccgcctcc tgggttcaag cgattctcct gcctcagcct cccgagttgt tgggattcca     2760

ggcatgcatg accaggctca gctaattttt gtttttttgg tagagacggg gtttcaccat     2820

attggccagg ctggtctcca actcctaatc tcaggtgatc tacccacctt ggcctcccaa     2880

attgctggga ttacaggcgt gaaccactgc tcccttccct gtccttctga ttttgtaggt     2940

aaccacgtgc ggaccgagcg gccgcaggaa cccctagtga tggagttggc cactccctct     3000

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     3060

gcccgggcgg cctcagtgag cgagcgagcg cgcagctgcc tgcaggggcg cctgatgcgg     3120

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tacgtcaaag caaccatagt     3180

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     3240

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     3300

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta     3360

gtgctttacg gcacctcgac cccaaaaaac ttgatttggg tgatggttca cgtagtgggc     3420

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg     3480

gactcttgtt ccaaactgga acaacactca accctatctc gggctattct tttgatttat     3540

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta     3600

acgcgaattt taacaaaata ttaacgttta caattttatg gtgcactctc agtacaatct     3660

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     3720

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     3780

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga     3840

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     3900

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     3960

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     4020

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     4080

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     4140

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     4200

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     4260

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     4320

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     4380

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     4440

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     4500

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     4560

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     4620

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     4680

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     4740

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     4800

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     4860

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     4920

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     4980

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     5040

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     5100

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     5160

aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt     5220

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     5280

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     5340

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     5400

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     5460

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     5520

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     5580

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     5640

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     5700

tgt                                                                   5703


<210>  11
<211>  950
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Gly Ile His Gly Pro Lys Arg Lys Leu Tyr Ser Ala Val Pro 
                245                 250                 255     


Gly Arg Lys Phe Ile Ala Val Lys Ala His Ser Pro Gln Gly Glu Gly 
            260                 265                 270         


Glu Ile Pro Leu His Arg Gly Glu Ala Val Lys Val Leu Ser Ile Gly 
        275                 280                 285             


Glu Gly Gly Phe Trp Glu Gly Thr Val Lys Gly Arg Thr Gly Trp Phe 
    290                 295                 300                 


Pro Ala Asp Cys Val Glu Glu Val Gln Met Arg Gln Tyr Asp Thr Arg 
305                 310                 315                 320 


His Glu Thr Arg Glu Asp Arg Thr Lys Arg Leu Phe Arg His Tyr Thr 
                325                 330                 335     


Val Gly Ser Tyr Asp Ser Leu Thr Ser His Ser Asp Tyr Val Ile Asp 
            340                 345                 350         


Asp Lys Val Ala Ile Leu Gln Lys Arg Asp His Glu Gly Phe Gly Phe 
        355                 360                 365             


Val Leu Arg Gly Ala Lys Ala Glu Thr Pro Ile Glu Glu Phe Thr Pro 
    370                 375                 380                 


Thr Pro Ala Phe Pro Ala Leu Gln Tyr Leu Glu Ser Val Asp Val Glu 
385                 390                 395                 400 


Gly Val Ala Trp Arg Ala Gly Leu Arg Thr Gly Asp Phe Leu Ile Glu 
                405                 410                 415     


Val Asn Gly Val Asn Val Val Lys Val Gly His Lys Gln Val Val Gly 
            420                 425                 430         


Leu Ile Arg Gln Gly Gly Asn Arg Leu Val Met Lys Val Val Ser Val 
        435                 440                 445             


Thr Arg Lys Pro Glu Glu Asp Gly Ala Arg Arg Arg Ala Pro Pro Pro 
    450                 455                 460                 


Pro Lys Arg Ala Pro Ser Thr Thr Leu Thr Leu Arg Ser Lys Ser Met 
465                 470                 475                 480 


Thr Ala Glu Leu Glu Glu Leu Ala Ser Ile Arg Ser Ser Glu Glu Glu 
                485                 490                 495     


Pro Glu Leu Val Phe Ala Val Asn Leu Pro Pro Ala Gln Leu Ser Ser 
            500                 505                 510         


Ser Asp Glu Glu Thr Arg Glu Glu Leu Ala Arg Ile Gly Leu Val Pro 
        515                 520                 525             


Pro Pro Glu Glu Phe Ala Asn Gly Ile Leu Leu Thr Thr Pro Pro Pro 
    530                 535                 540                 


Gly Pro Gly Pro Leu Pro Thr Thr Val Pro Ser Pro Ala Ser Gly Lys 
545                 550                 555                 560 


Pro Ser Ser Glu Leu Pro Pro Ala Pro Glu Ser Ala Ala Asp Ser Gly 
                565                 570                 575     


Val Glu Glu Ala Asp Thr Arg Ser Ser Ser Asp Pro His Leu Glu Thr 
            580                 585                 590         


Thr Ser Thr Ile Ser Thr Val Ser Ser Met Ser Thr Leu Ser Ser Glu 
        595                 600                 605             


Ser Gly Glu Leu Thr Asp Thr His Thr Ser Phe Ala Asp Gly His Thr 
    610                 615                 620                 


Phe Leu Leu Glu Lys Pro Pro Val Pro Pro Lys Pro Lys Leu Lys Ser 
625                 630                 635                 640 


Pro Leu Gly Lys Gly Pro Val Thr Phe Arg Asp Pro Leu Leu Lys Gln 
                645                 650                 655     


Ser Ser Asp Ser Glu Leu Met Ala Gln Gln His His Ala Ala Ser Thr 
            660                 665                 670         


Gly Leu Ala Ser Ala Ala Gly Pro Ala Arg Pro Arg Tyr Leu Phe Gln 
        675                 680                 685             


Arg Arg Ser Lys Leu Trp Gly Asp Pro Val Glu Ser Arg Gly Leu Pro 
    690                 695                 700                 


Gly Pro Glu Asp Asp Lys Pro Thr Val Ile Ser Glu Leu Ser Ser Arg 
705                 710                 715                 720 


Leu Gln Gln Leu Asn Lys Asp Thr Arg Ser Leu Gly Glu Glu Pro Val 
                725                 730                 735     


Gly Gly Leu Gly Ser Leu Leu Asp Pro Ala Lys Lys Ser Pro Ile Ala 
            740                 745                 750         


Ala Ala Arg Leu Phe Ser Ser Leu Gly Glu Leu Ser Thr Ile Ser Ala 
        755                 760                 765             


Gln Arg Ser Pro Gly Gly Pro Gly Gly Gly Ala Ser Tyr Ser Val Arg 
    770                 775                 780                 


Pro Ser Gly Arg Tyr Pro Val Ala Arg Arg Ala Pro Ser Pro Val Lys 
785                 790                 795                 800 


Pro Ala Ser Leu Glu Arg Val Glu Gly Leu Gly Ala Gly Val Gly Gly 
                805                 810                 815     


Ala Gly Arg Pro Phe Gly Leu Thr Pro Pro Thr Ile Leu Lys Ser Ser 
            820                 825                 830         


Ser Leu Ser Ile Pro His Glu Pro Lys Glu Val Arg Phe Val Val Arg 
        835                 840                 845             


Ser Val Ser Ala Arg Ser Arg Ser Pro Ser Pro Ser Pro Leu Pro Ser 
    850                 855                 860                 


Pro Ser Pro Gly Ser Gly Pro Ser Ala Gly Pro Arg Arg Pro Phe Gln 
865                 870                 875                 880 


Gln Lys Pro Leu Gln Leu Trp Ser Lys Phe Asp Val Gly Asp Trp Leu 
                885                 890                 895     


Glu Ser Ile His Leu Gly Glu His Arg Asp Arg Phe Glu Asp His Glu 
            900                 905                 910         


Ile Glu Gly Ala His Leu Pro Ala Leu Thr Lys Glu Asp Phe Val Glu 
        915                 920                 925             


Leu Gly Val Thr Arg Val Gly His Arg Met Asn Ile Glu Arg Ala Leu 
    930                 935                 940                 


Arg Gln Leu Asp Gly Ser 
945                 950 


<210>  12
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  13
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Pro Lys Lys Lys Arg Lys Val Cys Arg Ser His Gln Asn Leu Pro 
1               5                   10                  15      


Ala Leu Pro Val Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met 
            20                  25                  30          


Asp Met Phe Arg Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met 
        35                  40                  45              


Leu Leu Ser Val Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn 
    50                  55                  60                  


Arg Lys Trp Phe Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu 
65                  70                  75                  80  


Tyr Leu Gln Ala Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu 
                85                  90                  95      


Gly Gln Leu Asn Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser 
            100                 105                 110         


Asp Ser Asn Ala Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn 
        115                 120                 125             


Val Asp Ala Gly Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr 
    130                 135                 140                 


Asp Phe Asp Gln Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln 
145                 150                 155                 160 


Asp Ile Arg Asn Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu 
                165                 170                 175     


Arg Ile Ala Glu Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr 
            180                 185                 190         


Asp Gly Gly Arg Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val 
        195                 200                 205             


Ser Thr Ala Gly Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu 
    210                 215                 220                 


Val Glu Arg Trp Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn 
225                 230                 235                 240 


Tyr Leu Phe Cys Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala 
                245                 250                 255     


Thr Ser Gln Leu Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr 
            260                 265                 270         


His Arg Leu Ile Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu 
        275                 280                 285             


Ala Trp Ser Gly His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala 
    290                 295                 300                 


Arg Ala Gly Val Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr 
305                 310                 315                 320 


Asn Val Asn Ile Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr 
                325                 330                 335     


Gly Ala Met Val Arg Leu Leu Glu Asp Gly Asp Val Asn Val Ser Lys 
            340                 345                 350         


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
        355                 360                 365             


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
    370                 375                 380                 


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
385                 390                 395                 400 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
                405                 410                 415     


Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
            420                 425                 430         


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
        435                 440                 445             


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
    450                 455                 460                 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
465                 470                 475                 480 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
                485                 490                 495     


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
            500                 505                 510         


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
        515                 520                 525             


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
    530                 535                 540                 


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro 
545                 550                 555                 560 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
                565                 570                 575     


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            580                 585         


<210>  14
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Pro Lys Lys Lys Arg Lys Val Cys Arg Ser His Gln Asn Leu Pro 
1               5                   10                  15      


Ala Leu Pro Val Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met 
            20                  25                  30          


Asp Met Phe Arg Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met 
        35                  40                  45              


Leu Leu Ser Val Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn 
    50                  55                  60                  


Arg Lys Trp Phe Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu 
65                  70                  75                  80  


Tyr Leu Gln Ala Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu 
                85                  90                  95      


Gly Gln Leu Asn Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser 
            100                 105                 110         


Asp Ser Asn Ala Val Ser Leu Val Met Arg Arg Ile Arg Val Asn Val 
        115                 120                 125             


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
    130                 135                 140                 


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
145                 150                 155                 160 


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
                165                 170                 175     


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
            180                 185                 190         


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
        195                 200                 205             


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
    210                 215                 220                 


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
225                 230                 235                 240 


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
                245                 250                 255     


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
            260                 265                 270         


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
        275                 280                 285             


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
    290                 295                 300                 


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
305                 310                 315                 320 


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
                325                 330                 335     


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
            340                 345                 350         


Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
        355                 360                 365 


<210>  15
<211>  5193
<212>  DNA
<213>  Mus musculus

<400>  15
atggacggcc ccggggccag cgccgtggtc gtgcgcgtcg gcatcccgga cctgcaacaa       60

acgaagtgcc tgcgtctgga cccaaccgcg cccgtgtggg ccgccaagca gcgtgtgctc      120

tgcgccctca atcatagcct tcaagacgcg ctcaactacg ggctattcca gcctccctcc      180

cggggtcgcg ccggcaagtt cctggatgaa gagcggctct tacaggacta cccgcctaac      240

ctggacacgc ccctgcccta tctggagttc cgatacaagc ggagagttta tgcccagaac      300

ctcatagatg acaagcagtt tgcaaagcta cacacaaagg caaacctgaa gaagttcatg      360

gactatgtcc agctacacag cacagataag gtggcccgcc tgctggacaa ggggctggac      420

cccaatttcc atgaccctga ctcaggagag tgccctctga gccttgcggc acagttggac      480

aacgccactg acctcctgaa ggttctccgc aacggcggtg ctcatctgga cttccggacc      540

cgagatgggc tgacagccgt ccactgtgct acccgccagc ggaacgcagg ggcattgacg      600

accctgctgg acctgggggc ttcgcctgac tacaaggaca gccgcggcct gacgcccctg      660

taccatagtg ccctaggggg cggggatgcc ctctgttgcg agctgcttct ccatgatcat      720

gcacagctgg ggaccactga tgagaatggt tggcaagaga tccatcaggc ctgtcgcttt      780

ggacacgtgc agcacctgga gcaccttttg ttctatgggg ccaacatggg tgctcagaat      840

gcctcgggaa acacagccct gcacatctgt gccctctaca accaggagag ttgcgcgcgc      900

gtcctgcttt tccgtggtgc caacaaggac gtccgcaatt acaacagcca gacagccttc      960

caggtggcca ttattgcagg gaactttgag cttgccgagg taatcaagac ccacaaagac     1020

tccgatgtcg taccattcag ggaaaccccc agctatgcaa agcgacggcg tctggctggc     1080

ccgagtggcc tggcatcccc acggccctta cagcgctcag ccagtgatat caacctgaaa     1140

ggtgatcagc ccgcagcttc tccagggccc actctccgaa gcctccctca tcaactcttg     1200

ctccagaggc ttcaggagga gaaagaccgt gacagggatg gtgaactgga gaatgacatc     1260

agcggcccct cagcaggcag gggtggccac aacaagatca gccccagtgg gcccggcgga     1320

tccggccccg cgcccggccc cggcccggcg tctcccgcgc cccccgcgcc gccgccccgg     1380

ggcccgaagc ggaaacttta cagtgccgtc cccggccgca agttcatcgc tgtgaaggcg     1440

cacagcccgc agggcgaggg cgagatcccg ctgcaccgcg gcgaggccgt gaaggtgctc     1500

agcattgggg agggcggttt ctgggaggga accgtgaagg gccgaacagg ctggttccca     1560

gctgactgtg tggaagaagt gcagatgcga cagtatgaca cccggcatga aaccagagag     1620

gaccggacga agcgtctctt ccgccactac actgtgggtt cctatgacag cctcacttca     1680

cacagcgatt atgtcatcga tgataaggtg gctatcctgc agaaaaggga ccatgagggg     1740

tttggctttg ttctccgggg agccaaagca gagaccccca ttgaggagtt tacacccaca     1800

cctgccttcc ctgcactcca ataccttgag tctgtagatg tggaaggtgt ggcctggagg     1860

gctggacttc gaactgggga cttcctcatt gaggtgaacg gagtgaatgt cgtgaaggtt     1920

ggacacaagc aagtggtggg tctcatccgt cagggtggca accgcctggt catgaaggtt     1980

gtgtctgtga ccaggaaacc cgaggaggat ggtgctcggc gcagagcccc accaccccca     2040

aagagggctc ccagcaccac gctgaccctg cggtccaagt ccatgacggc tgagctcgag     2100

gaacttgctt ccattcggag aagaaaaggg gagaagttgg atgagatcct ggcagttgcc     2160

gcggagccga cactgaggcc ggacattgca gatgctgact cgagggcggc cactgtcaag     2220

cagcggccca ccagccggag gatcacccct gctgagatca gctcattgtt tgagcgccag     2280

ggcctcccag gcccagagaa gctgccgggc tctctgcgga aggggattcc acggaccaaa     2340

tctgtagggg aggatgagaa gctggcatcc ctactggaag ggcgcttccc acgcagcacg     2400

tcaatgcagg acacagtgcg tgaaggtcga ggcattccac ccccgccgca gaccgccccg     2460

ccacccccac ccgcgcccta ctacttcgac tccgggccac cccccacctt ctcaccgccg     2520

ccaccaccgg gccgggccta tgacactgtg cgctccagct tcaaaccagg cctggaggct     2580

cgtctgggtg cgggggccgc cggcctgtat gatccgagca cgcctctggg cccgctgccc     2640

taccctgagc gtcagaagcg tgcgcgctcc atgatcatac tgcaggactc tgcgccagaa     2700

gtgggtgatg tcccccggcc tgcgcctgcc gccacaccgc ctgagcgccc caagcgccgg     2760

cctcggccgt caggccctga tagtccctat gccaacctgg gcgccttcag tgccagcctc     2820

ttcgctccgt cgaaaccaca gcgccgcaag agcccgctgg tgaagcagct tcaggtggag     2880

gacgctcagg agcgcgcggc cctggccgtg ggtagcccgg gaccagtggg cggaagcttt     2940

gcacgagaac cctctccgac gcaccgcggg ccccggccag gcagccttga ctacagctct     3000

ggagaaggcc taggccttac cttcggcggc cctagccctg gcccagtcaa ggagcggcgc     3060

ctggaggagc gacgccgttc cactgtgttc ctctctgtgg gtgccatcga gggcagccct     3120

cccagcgcgg atctgccatc cctacaaccc tcccgctcca ttgatgagcg cctcctgggg     3180

acaggcgcca ccactggccg cgatttgcta ctcccctccc ctgtctctgc tctgaagcca     3240

ttggtcggtg gtcccagcct tgggccctca ggctccacct tcatccaccc tctcactggc     3300

aaacccttgg atcctagctc acccttagct cttgctctgg ctgcccggga gcgggctctg     3360

gcctcgcaaa caccttcccg gtcccccaca cctgtgcaca gccccgatgc tgaccgccct     3420

ggacccctct ttgtggatgt gcaaacccga gactctgaga gaggaccgtt ggcttcccca     3480

gccttctccc ctcggagtcc agcgtggatt ccagtgcctg ctcggagaga ggcagagaag     3540

ccccctcggg aagagcggaa gtcaccagag gacaagaagt ccatgatcct cagcgtcttg     3600

gacacgtcct tgcaacggcc agctggcctc attgttgtgc atgccaccag caatgggcag     3660

gagcccagca ggctgggggc tgaagaggag cgccccggta ctccggagct ggccccagcc     3720

cccatgcagg cagcagctgt ggcagagccc atgccaagcc cccgggccca gccccctggc     3780

agcatcccag cagatcccgg gccaggtcaa ggcagctcag aggaggagcc agagctggta     3840

ttcgctgtga acctgccacc tgctcagctg tcctccagcg atgaggagac cagagaggag     3900

ctggcccgca tagggctagt gccaccccct gaagagtttg ccaatgggat cctgctgacc     3960

accccgcccc cagggccggg ccccttgccc accacggtac ccagcccggc ctcagggaag     4020

cccagcagcg agctgccccc tgcccctgag tctgcagctg actctggagt agaggaggct     4080

gacactcgaa gctccagtga cccccacctg gagaccacaa gcaccatttc cacagtgtcc     4140

agcatgtcca ccctgagctc ggagagtggg gaactcacgg acacccacac ctcctttgcc     4200

gatggacaca cttttctact cgagaagcca ccagtgcctc ccaagcccaa gctcaagtcc     4260

ccgctgggga aggggccggt gaccttcagg gacccgctgc tgaagcaatc ctcggacagt     4320

gagctcatgg cccagcagca ccatgctgcc tctactgggt tggcttctgc tgctgggccc     4380

gcccgccctc gctacctctt ccagagaagg tccaagctgt ggggggaccc cgtggagagt     4440

cgggggctcc ctgggcctga agatgacaaa ccaactgtga tcagtgagct cagctcccgt     4500

ctgcagcagc tgaataaaga cacacgctcc ttgggggagg aaccagttgg tggcctgggc     4560

agcctgctgg accctgctaa gaagtcaccc attgcagcag ctcggctctt cagcagcctc     4620

ggtgagctga gcaccatctc agcgcagcgc agcccggggg gcccgggcgg aggggcctcc     4680

tactcggtgc ggcccagcgg ccggtacccc gtggcgagac gagccccgag cccagtgaaa     4740

cccgcatcgc tggagcgggt ggaggggctg ggggcgggcg tgggaggcgc ggggcggccc     4800

ttcggcctca cgcctcccac catcctcaag tcgtccagcc tctccatccc gcacgaaccc     4860

aaggaagtgc gcttcgtggt gcgaagtgtg agtgcgcgca gccgctcccc ctcaccatct     4920

ccgctgccct cgccttctcc cggctctggc cccagtgccg gcccgcgtcg gccatttcaa     4980

cagaagcccc tgcagctctg gagcaagttc gatgtgggcg actggctgga gagcatccac     5040

ttaggcgagc accgagaccg cttcgaggac catgagatcg aaggcgcaca cctgcctgcg     5100

ctcaccaagg aagacttcgt ggagctgggc gtcacacgcg ttggccaccg catgaacatc     5160

gagcgtgcgc tcaggcagct ggatggcagc tga                                  5193


<210>  16
<211>  5421
<212>  DNA
<213>  Homo sapiens

<400>  16
atgcagctga gccgcgccgc cgccgccgcc gccgccgccc ctgcggagcc cccggagccg       60

ctgtcccccg cgccggcccc ggccccggcc ccccccggcc ccctcccgcg cagcgcggcc      120

gacggggctc cggcgggggg gaaggggggg ccggggcgcc gcgcggagtc cccgggcgct      180

ccgttccccg gcgcgagcgg ccccggcccg ggccccggcg cggggatgga cggccccggg      240

gccagcgccg tggtcgtgcg cgtcggcatc ccggacctgc agcagacgaa gtgcctgcgc      300

ctggacccgg ccgcgcccgt gtgggccgcc aagcagcgcg tgctctgcgc cctcaaccac      360

agcctccagg acgcgctcaa ctatgggctt ttccagccgc cctcccgggg ccgcgccggc      420

aagttcctgg atgaggagcg gctcctgcag gagtacccgc ccaacctgga cacgcccctg      480

ccctacctgg agtttcgata caagcggcga gtttatgccc agaacctcat cgatgataag      540

cagtttgcaa agcttcacac aaaggcgaac ctgaagaagt tcatggacta cgtccagctg      600

catagcacgg acaaggtggc acgcctgttg gacaaggggc tggaccccaa cttccatgac      660

cctgactcag gagagtgccc cctgagcctc gcagcccagc tggacaacgc cacggacctg      720

ctaaaggtgc tgaagaatgg tggtgcccac ctggacttcc gcactcgcga tgggctcact      780

gccgtgcact gtgccacacg ccagcggaat gcggcagcac tgacgaccct gctggacctg      840

ggggcttcac ctgactacaa ggacagccgc ggcttgacac ccctctacca cagcgccctg      900

gggggtgggg atgccctctg ctgtgagctg cttctccacg accacgctca gctggggatc      960

accgacgaga atggctggca ggagatccac caggcctgcc gctttgggca cgtgcagcat     1020

ctggagcacc tgctgttcta tggggcagac atgggggccc agaacgcctc ggggaacaca     1080

gccctgcaca tctgtgccct ctacaaccag gagagctgtg ctcgtgtcct gctcttccgt     1140

ggagctaaca gggatgtccg caactacaac agccagacag ccttccaggt ggccatcatc     1200

gcagggaact ttgagcttgc agaggttatc aagacccaca aagactcgga tgttgtacca     1260

ttcagggaaa cccccagcta tgcgaagcgg cggcgactgg ctggccccag tggcttggca     1320

tcccctcggc ctctgcagcg ctcagccagc gatatcaacc tgaaggggga ggcacagcca     1380

gcagcttctc ctggaccctc gctgagaagc ctcccccacc agctgctgct ccagcggctg     1440

caagaggaga aagatcgtga ccgggatgcc gaccaggaga gcaacatcag tggcccttta     1500

gcaggcaggg ccggccaaag caagatcagc ccgagcgggc ccggcggccc cggccccgcg     1560

cccggccccg gccccgcgcc ccctgcgccc cccgcaccgc cgccccgggg cccgaagcgg     1620

aaactttaca gcgccgtccc cggccgcaag ttcatcgccg tgaaggcgca cagcccgcag     1680

ggtgaaggcg agatcccgct gcaccgcggc gaggccgtga aggtgctcag cattggggag     1740

ggcggtttct gggagggaac cgtgaaaggc cgcacgggct ggttcccggc cgactgcgtg     1800

gaggaagtgc agatgaggca gcatgacaca cggcctgaaa cgcgggagga ccggacgaag     1860

cggctctttc ggcactacac agtgggctcc tacgacagcc tcacctcaca cagcgattat     1920

gtcattgatg acaaagtggc tgtcctgcag aaacgggacc acgagggctt tggttttgtg     1980

ctccggggag ccaaagcaga gacccccatc gaggagttca cgcccacgcc agccttcccg     2040

gcgctgcagt atctcgagtc ggtggacgtg gagggtgtgg cctggagggc cgggctgcgc     2100

acgggagact tcctcatcga ggtgaacggg gtgaacgtgg tgaaggtcgg acacaagcag     2160

gtggtggctc tgattcgcca gggtggcaac cgcctcgtca tgaaggttgt gtctgtgaca     2220

aggaagccag aagaggacgg ggctcggcgc agagccccac cgccccccaa gagggccccc     2280

agcaccacac tgaccctgcg ctccaagtcc atgacagctg agctcgagga acttgcctcc     2340

attcggagaa gaaaagggga gaagctggac gagatgctgg cagccgccgc agagccaacg     2400

ctgcggccag acatcgcaga cgcagactcc agagccgcca ccgtcaaaca gaggcccacc     2460

agtcggagga tcacacccgc cgagattagc tcattgtttg aacgccaggg cctcccaggc     2520

ccagagaagc tgccgggctc cttgcggaag gggattccac ggaccaagtc tgtaggggag     2580

gacgagaagc tggcgtccct gctggaaggg cgcttcccgc ggagcacctc gatgcaagac     2640

ccggtgcgcg agggtcgcgg catcccgccc ccgccgcaga ccgcgccgcc tcccccgccc     2700

gcgccctact acttcgactc ggggccgccc ccggccttct cgccgccgcc cccgccgggc     2760

cgcgcctacg acacggtgcg ctccagcttc aagcccggcc tggaggcgcg cctgggcgcg     2820

ggcgctgccg gcctgtacga gccgggcgcg gccctcggcc cgctgccgta tcccgagcgg     2880

cagaagcgcg cgcgctccat gatcatcctg caggactcgg cgcccgagtc gggcgacgcc     2940

cctcgacccc cgcccgcggc caccccgccc gagcgaccca agcgccggcc gcggccgccc     3000

ggccccgaca gcccctacgc caacctgggc gccttcagcg ccagcctctt cgctccgtcc     3060

aagccgcagc gccgcaagag ccccctggtg aagcagctgc aggtggagga cgcgcaggag     3120

cgcgcggccc tggccgtggg cagccccggt cccggcggcg gcagcttcgc ccgcgagccc     3180

tccccgaccc accgcggtcc gcgcccgggt ggcctcgact acggcgcggg cgatggcccg     3240

gggctcgcgt tcggcggccc gggcccggcc aaggaccggc ggctggagga gcggcgccgc     3300

tccactgtgt tcctgtccgt gggggccatc gagggcagcg cccccggcgc ggatctgcca     3360

tccctacagc cctcccgctc catcgacgag cgcctcctgg ggaccggccc caccgccggc     3420

cgcgacctgc tgctgccctc cccggtgtct gccctgaagc cgttggtcag cggcccgagc     3480

ctggggccct cgggttccac cttcatccac ccactcaccg gcaaacccct ggaccccagc     3540

tcacccctgg cccttgccct ggctgcccga gagcgagctc tggcctccca ggcgccctcc     3600

cggtccccca cacccgtgca cagtcccgac gccgaccgcc ccggacccct gtttgtggat     3660

gtacaggccc gggacccaga gcgagggtcc ctggcttccc cggctttctc cccacggagc     3720

ccagcctgga ttcctgtgcc tgctcgcagg gaggcagaga aggtcccccg ggaggagcgg     3780

aagtcacccg aggacaagaa gtccatgatc ctcagcgtcc tggacacatc cctgcagcgg     3840

ccagctggcc tcatcgttgt gcacgccacc agcaacgggc aggagcccag caggctgggg     3900

ggggccgaag aggagcgccc gggcaccccg gagttggccc cggcccccat gcagtcagcg     3960

gctgtggcag agcccctgcc cagcccccgg gcccagcccc ctggtggcac cccggcagac     4020

gccgggccag gccagggcag ctcagaggaa gagccagagc tggtgtttgc tgtgaacctg     4080

ccacctgccc agctgtcgtc cagcgatgag gagaccaggg aggagctggc ccgaattggg     4140

ttggtgccac cccctgaaga gtttgccaac ggggtcctgc tggccacccc actcgctggc     4200

ccgggcccct cgcccaccac ggtgcccagc ccggcctcag ggaagcccag cagtgagcca     4260

ccccctgccc ctgagtctgc agccgactct ggggtggagg aggctgacac acgcagctcc     4320

agcgaccccc acctggagac cacaagcacc atctccacgg tgtccagcat gtccaccttg     4380

agctcggaga gcggggaact cactgacacc cacacctcct tcgctgacgg acacactttt     4440

ctactcgaga agccaccagt gcctcccaag cccaagctca agtccccgct ggggaagggg     4500

ccggtgacct tcagggaccc gctgctgaag cagtcctcgg acagcgagct catggcccag     4560

cagcaccacg ccgcctctgc cgggctggcc tctgccgccg ggcctgcccg ccctcgctac     4620

ctcttccaga gaaggtccaa gctatggggg gaccccgtgg agagccgggg gctccctggg     4680

cctgaagacg acaaaccaac tgtgatcagt gagctcagct cccgcctgca gcagctgaac     4740

aaggacacgc gttccctggg ggaggaacca gttggtggcc tgggcagcct gctggaccct     4800

gccaagaagt cgcccatcgc agcagctcgg ctcttcagca gcctcggtga gctgagctcc     4860

atttcagcgc agcgcagccc cgggggcccg ggcggcgggg cctcgtactc ggtgaggccc     4920

agtggccgct accccgtggc gagacgcgcc ccgagcccgg tgaagcccgc gtcgctggag     4980

cgggtggagg ggctgggggc gggcgcgggg ggcgcagggc ggcccttcgg cctcacgccc     5040

cccaccatcc tcaagtcgtc cagcctctcc atcccgcacg agcccaagga ggtgcgcttc     5100

gtggtgcgca gcgtgagcgc gcgcagtcgc tccccctcgc cgtcgccgct gccctcgccc     5160

gcgtccggcc ccggccccgg cgcccccggc ccacgccgac ccttccagca gaagccgctg     5220

cagctctgga gcaagttcga cgtgggcgac tggctggaga gcatccacct aggcgagcac     5280

cgcgaccgct tcgaggacca tgagatagaa ggcgcgcacc tacccgcgct taccaaggac     5340

gacttcgtgg agctgggcgt cacgcgcgtg ggccaccgca tgaacatcga gcgcgcgctc     5400

aggcagctgg acggcagctg a                                               5421


<210>  17
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Gly Pro Lys Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Lys Phe 
1               5                   10                  15      


Ile Ala Val Lys Ala His Ser Pro Gln Gly Glu Gly Glu Ile Pro Leu 
            20                  25                  30          


His Arg Gly Glu Ala Val Lys Val Leu Ser Ile Gly Glu Gly Gly Phe 
        35                  40                  45              


Trp Glu Gly Thr Val Lys Gly Arg Thr Gly Trp Phe Pro Ala Asp Cys 
    50                  55                  60                  


Val Glu Glu Val Gln Met Arg Gln Tyr Asp Thr Arg His Glu Thr Arg 
65                  70                  75                  80  


Glu Asp Arg Thr Lys Arg Leu Phe Arg His Tyr Thr Val Gly Ser Tyr 
                85                  90                  95      


Asp Ser Leu Thr Ser His Ser Asp Tyr Val Ile Asp Asp Lys Val Ala 
            100                 105                 110         


Ile Leu Gln Lys Arg Asp His Glu Gly Phe Gly Phe Val Leu Arg Gly 
        115                 120                 125             


Ala Lys Ala Glu Thr Pro Ile Glu Glu Phe Thr Pro Thr Pro Ala Phe 
    130                 135                 140                 


Pro Ala Leu Gln Tyr Leu Glu Ser Val Asp Val Glu Gly Val Ala Trp 
145                 150                 155                 160 


Arg Ala Gly Leu Arg Thr Gly Asp Phe Leu Ile Glu Val Asn Gly Val 
                165                 170                 175     


Asn Val Val Lys Val Gly His Lys Gln Val Val Gly Leu Ile Arg Gln 
            180                 185                 190         


Gly Gly Asn Arg Leu Val Met Lys Val Val Ser Val Thr Arg Lys Pro 
        195                 200                 205             


Glu Glu Asp Gly Ala Arg Arg Arg Ala Pro Pro Pro Pro Lys Arg Ala 
    210                 215                 220                 


Pro Ser Thr Thr Leu Thr Leu Arg Ser Lys Ser Met Thr Ala Glu Leu 
225                 230                 235                 240 


Glu Glu Leu Ala Ser Ile Arg Ser Ser Glu Glu Glu Pro Glu Leu Val 
                245                 250                 255     


Phe Ala Val Asn Leu Pro Pro Ala Gln Leu Ser Ser Ser Asp Glu Glu 
            260                 265                 270         


Thr Arg Glu Glu Leu Ala Arg Ile Gly Leu Val Pro Pro Pro Glu Glu 
        275                 280                 285             


Phe Ala Asn Gly Ile Leu Leu Thr Thr Pro Pro Pro Gly Pro Gly Pro 
    290                 295                 300                 


Leu Pro Thr Thr Val Pro Ser Pro Ala Ser Gly Lys Pro Ser Ser Glu 
305                 310                 315                 320 


Leu Pro Pro Ala Pro Glu Ser Ala Ala Asp Ser Gly Val Glu Glu Ala 
                325                 330                 335     


Asp Thr Arg Ser Ser Ser Asp Pro His Leu Glu Thr Thr Ser Thr Ile 
            340                 345                 350         


Ser Thr Val Ser Ser Met Ser Thr Leu Ser Ser Glu Ser Gly Glu Leu 
        355                 360                 365             


Thr Asp Thr His Thr Ser Phe Ala Asp Gly His Thr Phe Leu Leu Glu 
    370                 375                 380                 


Lys Pro Pro Val Pro Pro Lys Pro Lys Leu Lys Ser Pro Leu Gly Lys 
385                 390                 395                 400 


Gly Pro Val Thr Phe Arg Asp Pro Leu Leu Lys Gln Ser Ser Asp Ser 
                405                 410                 415     


Glu Leu Met Ala Gln Gln His His Ala Ala Ser Thr Gly Leu Ala Ser 
            420                 425                 430         


Ala Ala Gly Pro Ala Arg Pro Arg Tyr Leu Phe Gln Arg Arg Ser Lys 
        435                 440                 445             


Leu Trp Gly Asp Pro Val Glu Ser Arg Gly Leu Pro Gly Pro Glu Asp 
    450                 455                 460                 


Asp Lys Pro Thr Val Ile Ser Glu Leu Ser Ser Arg Leu Gln Gln Leu 
465                 470                 475                 480 


Asn Lys Asp Thr Arg Ser Leu Gly Glu Glu Pro Val Gly Gly Leu Gly 
                485                 490                 495     


Ser Leu Leu Asp Pro Ala Lys Lys Ser Pro Ile Ala Ala Ala Arg Leu 
            500                 505                 510         


Phe Ser Ser Leu Gly Glu Leu Ser Thr Ile Ser Ala Gln Arg Ser Pro 
        515                 520                 525             


Gly Gly Pro Gly Gly Gly Ala Ser Tyr Ser Val Arg Pro Ser Gly Arg 
    530                 535                 540                 


Tyr Pro Val Ala Arg Arg Ala Pro Ser Pro Val Lys Pro Ala Ser Leu 
545                 550                 555                 560 


Glu Arg Val Glu Gly Leu Gly Ala Gly Val Gly Gly Ala Gly Arg Pro 
                565                 570                 575     


Phe Gly Leu Thr Pro Pro Thr Ile Leu Lys Ser Ser Ser Leu Ser Ile 
            580                 585                 590         


Pro His Glu Pro Lys Glu Val Arg Phe Val Val Arg Ser Val Ser Ala 
        595                 600                 605             


Arg Ser Arg Ser Pro Ser Pro Ser Pro Leu Pro Ser Pro Ser Pro Gly 
    610                 615                 620                 


Ser Gly Pro Ser Ala Gly Pro Arg Arg Pro Phe Gln Gln Lys Pro Leu 
625                 630                 635                 640 


Gln Leu Trp Ser Lys Phe Asp Val Gly Asp Trp Leu Glu Ser Ile His 
                645                 650                 655     


Leu Gly Glu His Arg Asp Arg Phe Glu Asp His Glu Ile Glu Gly Ala 
            660                 665                 670         


His Leu Pro Ala Leu Thr Lys Glu Asp Phe Val Glu Leu Gly Val Thr 
        675                 680                 685             


Arg Val Gly His Arg Met Asn Ile Glu Arg Ala Leu Arg Gln Leu Asp 
    690                 695                 700                 


Gly Ser 
705     


<210>  18
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Gly Pro Lys Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Lys Phe 
1               5                   10                  15      


Ile Ala Val Lys Ala His Ser Pro Gln Gly Glu Gly Glu Ile Pro Leu 
            20                  25                  30          


His Arg Gly Glu Ala Val Lys Val Leu Ser Ile Gly Glu Gly Gly Phe 
        35                  40                  45              


Trp Glu Gly Thr Val Lys Gly Arg Thr Gly Trp Phe Pro Ala Asp Cys 
    50                  55                  60                  


Val Glu Glu Val Gln Met Arg Gln His Asp Thr Arg Pro Glu Thr Arg 
65                  70                  75                  80  


Glu Asp Arg Thr Lys Arg Leu Phe Arg His Tyr Thr Val Gly Ser Tyr 
                85                  90                  95      


Asp Ser Leu Thr Ser His Ser Asp Tyr Val Ile Asp Asp Lys Val Ala 
            100                 105                 110         


Val Leu Gln Lys Arg Asp His Glu Gly Phe Gly Phe Val Leu Arg Gly 
        115                 120                 125             


Ala Lys Ala Glu Thr Pro Ile Glu Glu Phe Thr Pro Thr Pro Ala Phe 
    130                 135                 140                 


Pro Ala Leu Gln Tyr Leu Glu Ser Val Asp Val Glu Gly Val Ala Trp 
145                 150                 155                 160 


Arg Ala Gly Leu Arg Thr Gly Asp Phe Leu Ile Glu Val Asn Gly Val 
                165                 170                 175     


Asn Val Val Lys Val Gly His Lys Gln Val Val Ala Leu Ile Arg Gln 
            180                 185                 190         


Gly Gly Asn Arg Leu Val Met Lys Val Val Ser Val Thr Arg Lys Pro 
        195                 200                 205             


Glu Glu Asp Gly Ala Arg Arg Arg Ala Pro Pro Pro Pro Lys Arg Ala 
    210                 215                 220                 


Pro Ser Thr Thr Leu Thr Leu Arg Ser Lys Ser Met Thr Ala Glu Leu 
225                 230                 235                 240 


Glu Glu Leu Ala Ser Ile Arg Ser Ser Glu Glu Glu Pro Glu Leu Val 
                245                 250                 255     


Phe Ala Val Asn Leu Pro Pro Ala Gln Leu Ser Ser Ser Asp Glu Glu 
            260                 265                 270         


Thr Arg Glu Glu Leu Ala Arg Ile Gly Leu Val Pro Pro Pro Glu Glu 
        275                 280                 285             


Phe Ala Asn Gly Val Leu Leu Ala Thr Pro Leu Ala Gly Pro Gly Pro 
    290                 295                 300                 


Ser Pro Thr Thr Val Pro Ser Pro Ala Ser Gly Lys Pro Ser Ser Glu 
305                 310                 315                 320 


Pro Pro Pro Ala Pro Glu Ser Ala Ala Asp Ser Gly Val Glu Glu Ala 
                325                 330                 335     


Asp Thr Arg Ser Ser Ser Asp Pro His Leu Glu Thr Thr Ser Thr Ile 
            340                 345                 350         


Ser Thr Val Ser Ser Met Ser Thr Leu Ser Ser Glu Ser Gly Glu Leu 
        355                 360                 365             


Thr Asp Thr His Thr Ser Phe Ala Asp Gly His Thr Phe Leu Leu Glu 
    370                 375                 380                 


Lys Pro Pro Val Pro Pro Lys Pro Lys Leu Lys Ser Pro Leu Gly Lys 
385                 390                 395                 400 


Gly Pro Val Thr Phe Arg Asp Pro Leu Leu Lys Gln Ser Ser Asp Ser 
                405                 410                 415     


Glu Leu Met Ala Gln Gln His His Ala Ala Ser Ala Gly Leu Ala Ser 
            420                 425                 430         


Ala Ala Gly Pro Ala Arg Pro Arg Tyr Leu Phe Gln Arg Arg Ser Lys 
        435                 440                 445             


Leu Trp Gly Asp Pro Val Glu Ser Arg Gly Leu Pro Gly Pro Glu Asp 
    450                 455                 460                 


Asp Lys Pro Thr Val Ile Ser Glu Leu Ser Ser Arg Leu Gln Gln Leu 
465                 470                 475                 480 


Asn Lys Asp Thr Arg Ser Leu Gly Glu Glu Pro Val Gly Gly Leu Gly 
                485                 490                 495     


Ser Leu Leu Asp Pro Ala Lys Lys Ser Pro Ile Ala Ala Ala Arg Leu 
            500                 505                 510         


Phe Ser Ser Leu Gly Glu Leu Ser Ser Ile Ser Ala Gln Arg Ser Pro 
        515                 520                 525             


Gly Gly Pro Gly Gly Gly Ala Ser Tyr Ser Val Arg Pro Ser Gly Arg 
    530                 535                 540                 


Tyr Pro Val Ala Arg Arg Ala Pro Ser Pro Val Lys Pro Ala Ser Leu 
545                 550                 555                 560 


Glu Arg Val Glu Gly Leu Gly Ala Gly Ala Gly Gly Ala Gly Arg Pro 
                565                 570                 575     


Phe Gly Leu Thr Pro Pro Thr Ile Leu Lys Ser Ser Ser Leu Ser Ile 
            580                 585                 590         


Pro His Glu Pro Lys Glu Val Arg Phe Val Val Arg Ser Val Ser Ala 
        595                 600                 605             


Arg Ser Arg Ser Pro Ser Pro Ser Pro Leu Pro Ser Pro Ala Ser Gly 
    610                 615                 620                 


Pro Gly Pro Gly Ala Pro Gly Pro Arg Arg Pro Phe Gln Gln Lys Pro 
625                 630                 635                 640 


Leu Gln Leu Trp Ser Lys Phe Asp Val Gly Asp Trp Leu Glu Ser Ile 
                645                 650                 655     


His Leu Gly Glu His Arg Asp Arg Phe Glu Asp His Glu Ile Glu Gly 
            660                 665                 670         


Ala His Leu Pro Ala Leu Thr Lys Asp Asp Phe Val Glu Leu Gly Val 
        675                 680                 685             


Thr Arg Val Gly His Arg Met Asn Ile Glu Arg Ala Leu Arg Gln Leu 
    690                 695                 700                 


Asp Gly Ser 
705         


<210>  19
<211>  1091
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Asp Gly Pro Gly Ala Ser Ala Val Val Val Arg Val Gly Ile Pro 
1               5                   10                  15      


Asp Leu Gln Gln Thr Lys Cys Leu Arg Leu Asp Pro Thr Ala Pro Val 
            20                  25                  30          


Trp Ala Ala Lys Gln Arg Val Leu Cys Ala Leu Asn His Ser Leu Gln 
        35                  40                  45              


Asp Ala Leu Asn Tyr Gly Leu Phe Gln Pro Pro Ser Arg Gly Arg Ala 
    50                  55                  60                  


Gly Lys Phe Leu Asp Glu Glu Arg Leu Leu Gln Asp Tyr Pro Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Pro Leu Pro Tyr Leu Glu Phe Arg Tyr Lys Arg Arg Val 
                85                  90                  95      


Tyr Ala Gln Asn Leu Ile Asp Asp Lys Gln Phe Ala Lys Leu His Thr 
            100                 105                 110         


Lys Ala Asn Leu Lys Lys Phe Met Asp Tyr Val Gln Leu His Ser Thr 
        115                 120                 125             


Asp Lys Val Ala Arg Leu Leu Asp Lys Gly Leu Asp Pro Asn Phe His 
    130                 135                 140                 


Asp Pro Asp Ser Gly Glu Cys Pro Leu Ser Leu Ala Ala Gln Leu Asp 
145                 150                 155                 160 


Asn Ala Thr Asp Leu Leu Lys Val Leu Arg Asn Gly Gly Ala His Leu 
                165                 170                 175     


Asp Phe Arg Thr Arg Asp Gly Leu Thr Ala Val His Cys Ala Thr Arg 
            180                 185                 190         


Gln Arg Asn Ala Gly Ala Leu Thr Thr Leu Leu Asp Leu Gly Ala Ser 
        195                 200                 205             


Pro Asp Tyr Lys Asp Ser Arg Gly Leu Thr Pro Leu Tyr His Ser Ala 
    210                 215                 220                 


Leu Gly Gly Gly Asp Ala Leu Cys Cys Glu Leu Leu Leu His Asp His 
225                 230                 235                 240 


Ala Gln Leu Gly Thr Thr Asp Glu Asn Gly Trp Gln Glu Ile His Gln 
                245                 250                 255     


Ala Cys Arg Phe Gly His Val Gln His Leu Glu His Leu Leu Phe Tyr 
            260                 265                 270         


Gly Ala Asn Met Gly Ala Gln Asn Ala Ser Gly Asn Thr Ala Leu His 
        275                 280                 285             


Ile Cys Ala Leu Tyr Asn Gln Glu Ser Cys Ala Arg Val Leu Leu Phe 
    290                 295                 300                 


Arg Gly Ala Asn Lys Asp Val Arg Asn Tyr Asn Ser Gln Thr Ala Phe 
305                 310                 315                 320 


Gln Val Ala Ile Ile Ala Gly Asn Phe Glu Leu Ala Glu Val Ile Lys 
                325                 330                 335     


Thr His Lys Asp Ser Asp Val Val Pro Phe Arg Glu Thr Pro Ser Tyr 
            340                 345                 350         


Ala Lys Arg Arg Arg Leu Ala Gly Pro Ser Gly Leu Ala Ser Pro Arg 
        355                 360                 365             


Pro Leu Gln Arg Ser Ala Ser Asp Ile Asn Leu Lys Gly Ala Pro Pro 
    370                 375                 380                 


Pro Arg Gly Pro Lys Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Lys 
385                 390                 395                 400 


Phe Ile Ala Val Lys Ala His Ser Pro Gln Gly Glu Gly Glu Ile Pro 
                405                 410                 415     


Leu His Arg Gly Glu Ala Val Lys Val Leu Ser Ile Gly Glu Gly Gly 
            420                 425                 430         


Phe Trp Glu Gly Thr Val Lys Gly Arg Thr Gly Trp Phe Pro Ala Asp 
        435                 440                 445             


Cys Val Glu Glu Val Gln Met Arg Gln Tyr Asp Thr Arg His Glu Thr 
    450                 455                 460                 


Arg Glu Asp Arg Thr Lys Arg Leu Phe Arg His Tyr Thr Val Gly Ser 
465                 470                 475                 480 


Tyr Asp Ser Leu Thr Ser His Ser Asp Tyr Val Ile Asp Asp Lys Val 
                485                 490                 495     


Ala Ile Leu Gln Lys Arg Asp His Glu Gly Phe Gly Phe Val Leu Arg 
            500                 505                 510         


Gly Ala Lys Ala Glu Thr Pro Ile Glu Glu Phe Thr Pro Thr Pro Ala 
        515                 520                 525             


Phe Pro Ala Leu Gln Tyr Leu Glu Ser Val Asp Val Glu Gly Val Ala 
    530                 535                 540                 


Trp Arg Ala Gly Leu Arg Thr Gly Asp Phe Leu Ile Glu Val Asn Gly 
545                 550                 555                 560 


Val Asn Val Val Lys Val Gly His Lys Gln Val Val Gly Leu Ile Arg 
                565                 570                 575     


Gln Gly Gly Asn Arg Leu Val Met Lys Val Val Ser Val Thr Arg Lys 
            580                 585                 590         


Pro Glu Glu Asp Gly Ala Arg Arg Arg Ala Pro Pro Pro Pro Lys Arg 
        595                 600                 605             


Ala Pro Ser Thr Thr Leu Thr Leu Arg Ser Lys Ser Met Thr Ala Glu 
    610                 615                 620                 


Leu Glu Glu Leu Ala Ser Ile Arg Ser Ser Glu Glu Glu Pro Glu Leu 
625                 630                 635                 640 


Val Phe Ala Val Asn Leu Pro Pro Ala Gln Leu Ser Ser Ser Asp Glu 
                645                 650                 655     


Glu Thr Arg Glu Glu Leu Ala Arg Ile Gly Leu Val Pro Pro Pro Glu 
            660                 665                 670         


Glu Phe Ala Asn Gly Ile Leu Leu Thr Thr Pro Pro Pro Gly Pro Gly 
        675                 680                 685             


Pro Leu Pro Thr Thr Val Pro Ser Pro Ala Ser Gly Lys Pro Ser Ser 
    690                 695                 700                 


Glu Leu Pro Pro Ala Pro Glu Ser Ala Ala Asp Ser Gly Val Glu Glu 
705                 710                 715                 720 


Ala Asp Thr Arg Ser Ser Ser Asp Pro His Leu Glu Thr Thr Ser Thr 
                725                 730                 735     


Ile Ser Thr Val Ser Ser Met Ser Thr Leu Ser Ser Glu Ser Gly Glu 
            740                 745                 750         


Leu Thr Asp Thr His Thr Ser Phe Ala Asp Gly His Thr Phe Leu Leu 
        755                 760                 765             


Glu Lys Pro Pro Val Pro Pro Lys Pro Lys Leu Lys Ser Pro Leu Gly 
    770                 775                 780                 


Lys Gly Pro Val Thr Phe Arg Asp Pro Leu Leu Lys Gln Ser Ser Asp 
785                 790                 795                 800 


Ser Glu Leu Met Ala Gln Gln His His Ala Ala Ser Thr Gly Leu Ala 
                805                 810                 815     


Ser Ala Ala Gly Pro Ala Arg Pro Arg Tyr Leu Phe Gln Arg Arg Ser 
            820                 825                 830         


Lys Leu Trp Gly Asp Pro Val Glu Ser Arg Gly Leu Pro Gly Pro Glu 
        835                 840                 845             


Asp Asp Lys Pro Thr Val Ile Ser Glu Leu Ser Ser Arg Leu Gln Gln 
    850                 855                 860                 


Leu Asn Lys Asp Thr Arg Ser Leu Gly Glu Glu Pro Val Gly Gly Leu 
865                 870                 875                 880 


Gly Ser Leu Leu Asp Pro Ala Lys Lys Ser Pro Ile Ala Ala Ala Arg 
                885                 890                 895     


Leu Phe Ser Ser Leu Gly Glu Leu Ser Thr Ile Ser Ala Gln Arg Ser 
            900                 905                 910         


Pro Gly Gly Pro Gly Gly Gly Ala Ser Tyr Ser Val Arg Pro Ser Gly 
        915                 920                 925             


Arg Tyr Pro Val Ala Arg Arg Ala Pro Ser Pro Val Lys Pro Ala Ser 
    930                 935                 940                 


Leu Glu Arg Val Glu Gly Leu Gly Ala Gly Val Gly Gly Ala Gly Arg 
945                 950                 955                 960 


Pro Phe Gly Leu Thr Pro Pro Thr Ile Leu Lys Ser Ser Ser Leu Ser 
                965                 970                 975     


Ile Pro His Glu Pro Lys Glu Val Arg Phe Val Val Arg Ser Val Ser 
            980                 985                 990         


Ala Arg Ser Arg Ser Pro Ser Pro  Ser Pro Leu Pro Ser  Pro Ser Pro 
        995                 1000                 1005             


Gly Ser  Gly Pro Ser Ala Gly  Pro Arg Arg Pro Phe  Gln Gln Lys 
    1010                 1015                 1020             


Pro Leu  Gln Leu Trp Ser Lys  Phe Asp Val Gly Asp  Trp Leu Glu 
    1025                 1030                 1035             


Ser Ile  His Leu Gly Glu His  Arg Asp Arg Phe Glu  Asp His Glu 
    1040                 1045                 1050             


Ile Glu  Gly Ala His Leu Pro  Ala Leu Thr Lys Glu  Asp Phe Val 
    1055                 1060                 1065             


Glu Leu  Gly Val Thr Arg Val  Gly His Arg Met Asn  Ile Glu Arg 
    1070                 1075                 1080             


Ala Leu  Arg Gln Leu Asp Gly  Ser 
    1085                 1090     


<210>  20
<211>  1092
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Asp Gly Pro Gly Ala Ser Ala Val Val Val Arg Val Gly Ile Pro 
1               5                   10                  15      


Asp Leu Gln Gln Thr Lys Cys Leu Arg Leu Asp Pro Ala Ala Pro Val 
            20                  25                  30          


Trp Ala Ala Lys Gln Arg Val Leu Cys Ala Leu Asn His Ser Leu Gln 
        35                  40                  45              


Asp Ala Leu Asn Tyr Gly Leu Phe Gln Pro Pro Ser Arg Gly Arg Ala 
    50                  55                  60                  


Gly Lys Phe Leu Asp Glu Glu Arg Leu Leu Gln Glu Tyr Pro Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Pro Leu Pro Tyr Leu Glu Phe Arg Tyr Lys Arg Arg Val 
                85                  90                  95      


Tyr Ala Gln Asn Leu Ile Asp Asp Lys Gln Phe Ala Lys Leu His Thr 
            100                 105                 110         


Lys Ala Asn Leu Lys Lys Phe Met Asp Tyr Val Gln Leu His Ser Thr 
        115                 120                 125             


Asp Lys Val Ala Arg Leu Leu Asp Lys Gly Leu Asp Pro Asn Phe His 
    130                 135                 140                 


Asp Pro Asp Ser Gly Glu Cys Pro Leu Ser Leu Ala Ala Gln Leu Asp 
145                 150                 155                 160 


Asn Ala Thr Asp Leu Leu Lys Val Leu Lys Asn Gly Gly Ala His Leu 
                165                 170                 175     


Asp Phe Arg Thr Arg Asp Gly Leu Thr Ala Val His Cys Ala Thr Arg 
            180                 185                 190         


Gln Arg Asn Ala Ala Ala Leu Thr Thr Leu Leu Asp Leu Gly Ala Ser 
        195                 200                 205             


Pro Asp Tyr Lys Asp Ser Arg Gly Leu Thr Pro Leu Tyr His Ser Ala 
    210                 215                 220                 


Leu Gly Gly Gly Asp Ala Leu Cys Cys Glu Leu Leu Leu His Asp His 
225                 230                 235                 240 


Ala Gln Leu Gly Ile Thr Asp Glu Asn Gly Trp Gln Glu Ile His Gln 
                245                 250                 255     


Ala Cys Arg Phe Gly His Val Gln His Leu Glu His Leu Leu Phe Tyr 
            260                 265                 270         


Gly Ala Asp Met Gly Ala Gln Asn Ala Ser Gly Asn Thr Ala Leu His 
        275                 280                 285             


Ile Cys Ala Leu Tyr Asn Gln Glu Ser Cys Ala Arg Val Leu Leu Phe 
    290                 295                 300                 


Arg Gly Ala Asn Arg Asp Val Arg Asn Tyr Asn Ser Gln Thr Ala Phe 
305                 310                 315                 320 


Gln Val Ala Ile Ile Ala Gly Asn Phe Glu Leu Ala Glu Val Ile Lys 
                325                 330                 335     


Thr His Lys Asp Ser Asp Val Val Pro Phe Arg Glu Thr Pro Ser Tyr 
            340                 345                 350         


Ala Lys Arg Arg Arg Leu Ala Gly Pro Ser Gly Leu Ala Ser Pro Arg 
        355                 360                 365             


Pro Leu Gln Arg Ser Ala Ser Asp Ile Asn Leu Lys Gly Ala Pro Pro 
    370                 375                 380                 


Pro Arg Gly Pro Lys Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Lys 
385                 390                 395                 400 


Phe Ile Ala Val Lys Ala His Ser Pro Gln Gly Glu Gly Glu Ile Pro 
                405                 410                 415     


Leu His Arg Gly Glu Ala Val Lys Val Leu Ser Ile Gly Glu Gly Gly 
            420                 425                 430         


Phe Trp Glu Gly Thr Val Lys Gly Arg Thr Gly Trp Phe Pro Ala Asp 
        435                 440                 445             


Cys Val Glu Glu Val Gln Met Arg Gln His Asp Thr Arg Pro Glu Thr 
    450                 455                 460                 


Arg Glu Asp Arg Thr Lys Arg Leu Phe Arg His Tyr Thr Val Gly Ser 
465                 470                 475                 480 


Tyr Asp Ser Leu Thr Ser His Ser Asp Tyr Val Ile Asp Asp Lys Val 
                485                 490                 495     


Ala Val Leu Gln Lys Arg Asp His Glu Gly Phe Gly Phe Val Leu Arg 
            500                 505                 510         


Gly Ala Lys Ala Glu Thr Pro Ile Glu Glu Phe Thr Pro Thr Pro Ala 
        515                 520                 525             


Phe Pro Ala Leu Gln Tyr Leu Glu Ser Val Asp Val Glu Gly Val Ala 
    530                 535                 540                 


Trp Arg Ala Gly Leu Arg Thr Gly Asp Phe Leu Ile Glu Val Asn Gly 
545                 550                 555                 560 


Val Asn Val Val Lys Val Gly His Lys Gln Val Val Ala Leu Ile Arg 
                565                 570                 575     


Gln Gly Gly Asn Arg Leu Val Met Lys Val Val Ser Val Thr Arg Lys 
            580                 585                 590         


Pro Glu Glu Asp Gly Ala Arg Arg Arg Ala Pro Pro Pro Pro Lys Arg 
        595                 600                 605             


Ala Pro Ser Thr Thr Leu Thr Leu Arg Ser Lys Ser Met Thr Ala Glu 
    610                 615                 620                 


Leu Glu Glu Leu Ala Ser Ile Arg Ser Ser Glu Glu Glu Pro Glu Leu 
625                 630                 635                 640 


Val Phe Ala Val Asn Leu Pro Pro Ala Gln Leu Ser Ser Ser Asp Glu 
                645                 650                 655     


Glu Thr Arg Glu Glu Leu Ala Arg Ile Gly Leu Val Pro Pro Pro Glu 
            660                 665                 670         


Glu Phe Ala Asn Gly Val Leu Leu Ala Thr Pro Leu Ala Gly Pro Gly 
        675                 680                 685             


Pro Ser Pro Thr Thr Val Pro Ser Pro Ala Ser Gly Lys Pro Ser Ser 
    690                 695                 700                 


Glu Pro Pro Pro Ala Pro Glu Ser Ala Ala Asp Ser Gly Val Glu Glu 
705                 710                 715                 720 


Ala Asp Thr Arg Ser Ser Ser Asp Pro His Leu Glu Thr Thr Ser Thr 
                725                 730                 735     


Ile Ser Thr Val Ser Ser Met Ser Thr Leu Ser Ser Glu Ser Gly Glu 
            740                 745                 750         


Leu Thr Asp Thr His Thr Ser Phe Ala Asp Gly His Thr Phe Leu Leu 
        755                 760                 765             


Glu Lys Pro Pro Val Pro Pro Lys Pro Lys Leu Lys Ser Pro Leu Gly 
    770                 775                 780                 


Lys Gly Pro Val Thr Phe Arg Asp Pro Leu Leu Lys Gln Ser Ser Asp 
785                 790                 795                 800 


Ser Glu Leu Met Ala Gln Gln His His Ala Ala Ser Ala Gly Leu Ala 
                805                 810                 815     


Ser Ala Ala Gly Pro Ala Arg Pro Arg Tyr Leu Phe Gln Arg Arg Ser 
            820                 825                 830         


Lys Leu Trp Gly Asp Pro Val Glu Ser Arg Gly Leu Pro Gly Pro Glu 
        835                 840                 845             


Asp Asp Lys Pro Thr Val Ile Ser Glu Leu Ser Ser Arg Leu Gln Gln 
    850                 855                 860                 


Leu Asn Lys Asp Thr Arg Ser Leu Gly Glu Glu Pro Val Gly Gly Leu 
865                 870                 875                 880 


Gly Ser Leu Leu Asp Pro Ala Lys Lys Ser Pro Ile Ala Ala Ala Arg 
                885                 890                 895     


Leu Phe Ser Ser Leu Gly Glu Leu Ser Ser Ile Ser Ala Gln Arg Ser 
            900                 905                 910         


Pro Gly Gly Pro Gly Gly Gly Ala Ser Tyr Ser Val Arg Pro Ser Gly 
        915                 920                 925             


Arg Tyr Pro Val Ala Arg Arg Ala Pro Ser Pro Val Lys Pro Ala Ser 
    930                 935                 940                 


Leu Glu Arg Val Glu Gly Leu Gly Ala Gly Ala Gly Gly Ala Gly Arg 
945                 950                 955                 960 


Pro Phe Gly Leu Thr Pro Pro Thr Ile Leu Lys Ser Ser Ser Leu Ser 
                965                 970                 975     


Ile Pro His Glu Pro Lys Glu Val Arg Phe Val Val Arg Ser Val Ser 
            980                 985                 990         


Ala Arg Ser Arg Ser Pro Ser Pro  Ser Pro Leu Pro Ser  Pro Ala Ser 
        995                 1000                 1005             


Gly Pro  Gly Pro Gly Ala Pro  Gly Pro Arg Arg Pro  Phe Gln Gln 
    1010                 1015                 1020             


Lys Pro  Leu Gln Leu Trp Ser  Lys Phe Asp Val Gly  Asp Trp Leu 
    1025                 1030                 1035             


Glu Ser  Ile His Leu Gly Glu  His Arg Asp Arg Phe  Glu Asp His 
    1040                 1045                 1050             


Glu Ile  Glu Gly Ala His Leu  Pro Ala Leu Thr Lys  Asp Asp Phe 
    1055                 1060                 1065             


Val Glu  Leu Gly Val Thr Arg  Val Gly His Arg Met  Asn Ile Glu 
    1070                 1075                 1080             


Arg Ala  Leu Arg Gln Leu Asp  Gly Ser 
    1085                 1090         


<210>  21
<211>  6701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtttaat taagtgtcta gactgcagag      180

ggccctgcgt atgagtgcaa gtgggtttta ggaccaggat gaggcggggt gggggtgcct      240

acctgacgac cgaccccgac ccactggaca agcacccaac ccccattccc caaattgcgc      300

atcccctatc agagaggggg aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag      360

cttcagcacc gcggacagtg ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca      420

gcactgaagg cgcgctgacg tcactcgccg gtcccccgca aactcccctt cccggccacc      480

ttggtcgcgt ccgcgccgcc gccggcccag ccggaccgca ccacgcgagg cgcgagatag      540

gggggcacgg gcgcgaccat ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg      600

cggtgggcag cggaggagtc gtgtcgtgcc tgagagcgca gtcgagaaac cggctagagg      660

atccttcgaa accggtgcta gcatgggccc gaagcggaaa ctttacagcg ccgtccccgg      720

ccgcaagttc atcgccgtga aggcgcacag cccgcagggt gaaggcgaga tcccgctgca      780

ccgcggcgag gccgtgaagg tgctcagcat tggggagggc ggtttctggg agggaaccgt      840

gaaaggccgc acgggctggt tcccggccga ctgcgtggag gaagtgcaga tgaggcagca      900

tgacacacgg cctgaaacgc gggaggaccg gacgaagcgg ctctttcggc actacacagt      960

gggctcctac gacagcctca cctcacacag cgattatgtc attgatgaca aagtggctgt     1020

cctgcagaaa cgggaccacg agggctttgg ttttgtgctc cggggagcca aagcagagac     1080

ccccatcgag gagttcacgc ccacgccagc cttcccggcg ctgcagtatc tcgagtcggt     1140

ggacgtggag ggtgtggcct ggagggccgg gctgcgcacg ggagacttcc tcatcgaggt     1200

gaacggggtg aacgtggtga aggtcggaca caagcaggtg gtggctctga ttcgccaggg     1260

tggcaaccgc ctcgtcatga aggttgtgtc tgtgacaagg aagccagaag aggacggggc     1320

tcggcgcaga gccccaccgc cccccaagag ggcccccagc accacactga ccctgcgctc     1380

caagtccatg acagctgagc tcgaggaact tgcctccatt cggagctcag aggaagagcc     1440

agagctggtg tttgctgtga acctgccacc tgcccagctg tcgtccagcg atgaggagac     1500

cagggaggag ctggcccgaa ttgggttggt gccaccccct gaagagtttg ccaacggggt     1560

cctgctggcc accccactcg ctggcccggg cccctcgccc accacggtgc ccagcccggc     1620

ctcagggaag cccagcagtg agccaccccc tgcccctgag tctgcagccg actctggggt     1680

ggaggaggct gacacacgca gctccagcga cccccacctg gagaccacaa gcaccatctc     1740

cacggtgtcc agcatgtcca ccttgagctc ggagagcggg gaactcactg acacccacac     1800

ctccttcgct gacggacaca cttttctact cgagaagcca ccagtgcctc ccaagcccaa     1860

gctcaagtcc ccgctgggga aggggccggt gaccttcagg gacccgctgc tgaagcagtc     1920

ctcggacagc gagctcatgg cccagcagca ccacgccgcc tctgccgggc tggcctctgc     1980

cgccgggcct gcccgccctc gctacctctt ccagagaagg tccaagctat ggggggaccc     2040

cgtggagagc cgggggctcc ctgggcctga agacgacaaa ccaactgtga tcagtgagct     2100

cagctcccgc ctgcagcagc tgaacaagga cacgcgttcc ctgggggagg aaccagttgg     2160

tggcctgggc agcctgctgg accctgccaa gaagtcgccc atcgcagcag ctcggctctt     2220

cagcagcctc ggtgagctga gctccatttc agcgcagcgc agccccgggg gcccgggcgg     2280

cggggcctcg tactcggtga ggcccagtgg ccgctacccc gtggcgagac gcgccccgag     2340

cccggtgaag cccgcgtcgc tggagcgggt ggaggggctg ggggcgggcg cggggggcgc     2400

agggcggccc ttcggcctca cgccccccac catcctcaag tcgtccagcc tctccatccc     2460

gcacgagccc aaggaggtgc gcttcgtggt gcgcagcgtg agcgcgcgca gtcgctcccc     2520

ctcgccgtcg ccgctgccct cgcccgcgtc cggccccggc cccggcgccc ccggcccacg     2580

ccgacccttc cagcagaagc cgctgcagct ctggagcaag ttcgacgtgg gcgactggct     2640

ggagagcatc cacctaggcg agcaccgcga ccgcttcgag gaccatgaga tagaaggcgc     2700

gcacctaccc gcgcttacca aggacgactt cgtggagctg ggcgtcacgc gcgtgggcca     2760

ccgcatgaac atcgagcgcg cgctcaggca gctggacggc agctgacggc gcgccaagct     2820

tatcgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     2880

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     2940

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     3000

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     3060

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     3120

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     3180

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg     3240

gctgctcgcc tatgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     3300

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     3360

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcatcg     3420

ataccgagcg ctgctcgaga gatctacggg tggcatccct gtgacccctc cccagtgcct     3480

ctcctggccc tggaagttgc cactccagtg cccaccagcc ttgtcctaat aaaattaagt     3540

tgcatcattt tgtctgacta ggtgtccttc tataatatta tggggtggag gggggtggta     3600

tggagcaagg ggcaagttgg gaagacaacc tgtagggcct gcggggtcta ttgggaacca     3660

agctggagtg cagtggcaca atcttggctc actgcaatct ccgcctcctg ggttcaagcg     3720

attctcctgc ctcagcctcc cgagttgttg ggattccagg catgcatgac caggctcagc     3780

taatttttgt ttttttggta gagacggggt ttcaccatat tggccaggct ggtctccaac     3840

tcctaatctc aggtgatcta cccaccttgg cctcccaaat tgctgggatt acaggcgtga     3900

accactgctc ccttccctgt ccttctgatt ttgtaggtaa ccacgtgcgg accgagcggc     3960

cgcaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     4020

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg     4080

agcgagcgcg cagctgcctg caggggcgcc tgatgcggta ttttctcctt acgcatctgt     4140

gcggtatttc acaccgcata cgtcaaagca accatagtac gcgccctgta gcggcgcatt     4200

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     4260

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     4320

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     4380

caaaaaactt gatttgggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     4440

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     4500

aacactcaac cctatctcgg gctattcttt tgatttataa gggattttgc cgatttcggc     4560

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt     4620

aacgtttaca attttatggt gcactctcag tacaatctgc tctgatgccg catagttaag     4680

ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc     4740

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc     4800

gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa     4860

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg     4920

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     4980

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     5040

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     5100

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     5160

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat     5220

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga     5280

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac     5340

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat     5400

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac     5460

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct     5520

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac     5580

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga     5640

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg     5700

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact     5760

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac     5820

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta     5880

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt     5940

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga     6000

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc     6060

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt     6120

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc     6180

gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc     6240

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg     6300

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg     6360

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga     6420

actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc     6480

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg     6540

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg     6600

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt     6660

tttacggttc ctggcctttt gctggccttt tgctcacatg t                         6701


<210>  22
<211>  495
<212>  DNA
<213>  Homo sapiens

<400>  22
gtgtctagac tgcagagggc cctgcgtatg agtgcaagtg ggttttagga ccaggatgag       60

gcggggtggg ggtgcctacc tgacgaccga ccccgaccca ctggacaagc acccaacccc      120

cattccccaa attgcgcatc ccctatcaga gagggggagg ggaaacagga tgcggcgagg      180

cgcgtgcgca ctgccagctt cagcaccgcg gacagtgcct tcgcccccgc ctggcggcgc      240

gcgccaccgc cgcctcagca ctgaaggcgc gctgacgtca ctcgccggtc ccccgcaaac      300

tccccttccc ggccaccttg gtcgcgtccg cgccgccgcc ggcccagccg gaccgcacca      360

cgcgaggcgc gagatagggg ggcacgggcg cgaccatctg cgctgcggcg ccggcgactc      420

agcgctgcct cagtctgcgg tgggcagcgg aggagtcgtg tcgtgcctga gagcgcagtc      480

gagaaaccgg ctaga                                                       495


