<110>    Korea Research Institute of Bioscience and Biotechnology
         Kyungpook National University Industry-Academic Cooperation Foundation
         Research Cooperation Foundation of Yeungnam University

<120>    Composition for diagnosing infectious inflammatory disease
         comprising agents detecting the expression level of SREBP2

<130>    OP21-0083/PCT

<150>    KR 10-2020-0104962
<151>    2020-08-20

<160>    3

<170>    KoPatentIn 3.0

<210>    1
<211>    1016
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SREBP2 protein


<400>    1
Met Asp Asp Ser Gly Glu Leu Gly Gly Leu Glu Thr Met Glu Thr Leu
  1               5                  10                  15 

Thr Glu Leu Gly Asp Glu Leu Thr Leu Gly Asp Ile Asp Glu Met Leu
             20                  25                  30 

Gln Phe Val Ser Asn Gln Val Gly Glu Phe Pro Asp Leu Phe Ser Glu
         35                  40                  45 

Gln Leu Cys Ser Ser Phe Pro Gly Ser Gly Gly Ser Gly Ser Ser Ser
     50                  55                  60 

Gly Ser Ser Gly Ser Ser Ser Ser Ser Ser Asn Gly Arg Gly Ser Ser
 65                  70                  75                  80 

Ser Gly Ala Val Asp Pro Ser Val Gln Arg Ser Phe Thr Gln Val Thr
                 85                  90                  95 

Leu Pro Ser Phe Ser Pro Ser Ala Ala Ser Pro Gln Ala Pro Thr Leu
            100                 105                 110 

Gln Val Lys Val Ser Pro Thr Ser Val Pro Thr Thr Pro Arg Ala Thr
        115                 120                 125 

Pro Ile Leu Gln Pro Arg Pro Gln Pro Gln Pro Gln Pro Gln Thr Gln
    130                 135                 140 

Leu Gln Gln Gln Thr Val Met Ile Thr Pro Thr Phe Ser Thr Thr Pro
145                 150                 155                 160 

Gln Thr Arg Ile Ile Gln Gln Pro Leu Ile Tyr Gln Asn Ala Ala Thr
                165                 170                 175 

Ser Phe Gln Val Leu Gln Pro Gln Val Gln Ser Leu Val Thr Ser Ser
            180                 185                 190 

Gln Val Gln Pro Val Thr Ile Gln Gln Gln Val Gln Thr Val Gln Ala
        195                 200                 205 

Gln Arg Val Leu Thr Gln Thr Ala Asn Gly Thr Leu Gln Thr Leu Ala
    210                 215                 220 

Pro Ala Thr Val Gln Thr Val Ala Ala Pro Gln Val Gln Gln Val Pro
225                 230                 235                 240 

Val Leu Val Gln Pro Gln Ile Ile Lys Thr Asp Ser Leu Val Leu Thr
                245                 250                 255 

Thr Leu Lys Thr Asp Gly Ser Pro Val Met Ala Ala Val Gln Asn Pro
            260                 265                 270 

Ala Leu Thr Ala Leu Thr Thr Pro Ile Gln Thr Ala Ala Leu Gln Val
        275                 280                 285 

Pro Thr Leu Val Gly Ser Ser Gly Thr Ile Leu Thr Thr Met Pro Val
    290                 295                 300 

Met Met Gly Gln Glu Lys Val Pro Ile Lys Gln Val Pro Gly Gly Val
305                 310                 315                 320 

Lys Gln Leu Glu Pro Pro Lys Glu Gly Glu Arg Arg Thr Thr His Asn
                325                 330                 335 

Ile Ile Glu Lys Arg Tyr Arg Ser Ser Ile Asn Asp Lys Ile Ile Glu
            340                 345                 350 

Leu Lys Asp Leu Val Met Gly Thr Asp Ala Lys Met His Lys Ser Gly
        355                 360                 365 

Val Leu Arg Lys Ala Ile Asp Tyr Ile Lys Tyr Leu Gln Gln Val Asn
    370                 375                 380 

His Lys Leu Arg Gln Glu Asn Met Val Leu Lys Leu Ala Asn Gln Lys
385                 390                 395                 400 

Asn Lys Leu Leu Lys Gly Ile Asp Leu Gly Ser Leu Val Asp Asn Glu
                405                 410                 415 

Val Asp Leu Lys Ile Glu Asp Phe Asn Gln Asn Val Leu Leu Met Ser
            420                 425                 430 

Pro Pro Ala Ser Asp Ser Gly Ser Gln Ala Gly Phe Ser Pro Tyr Ser
        435                 440                 445 

Ile Asp Ser Glu Pro Gly Ser Pro Leu Leu Asp Asp Ala Lys Gly Asp
    450                 455                 460 

Phe Ala Ala Ala Ala Gly Asn Leu Gln Thr Cys Leu Ala Val Leu Gly
465                 470                 475                 480 

Arg Ala Leu Pro Thr Ser Arg Leu Asp Leu Ala Cys Ser Leu Ser Trp
                485                 490                 495 

Asn Val Ile Arg Tyr Ser Leu Gln Lys Leu Arg Leu Val Arg Trp Leu
            500                 505                 510 

Leu Lys Lys Val Phe Gln Cys Arg Arg Ala Thr Pro Ala Thr Glu Ala
        515                 520                 525 

Gly Phe Glu Asp Glu Ala Lys Thr Ser Ala Arg Asp Ala Ala Leu Ala
    530                 535                 540 

Tyr His Arg Leu His Gln Leu His Ile Thr Gly Lys Leu Pro Ala Gly
545                 550                 555                 560 

Ser Ala Cys Ser Asp Val His Met Ala Leu Cys Ala Val Asn Leu Ala
                565                 570                 575 

Glu Cys Ala Glu Glu Lys Ile Pro Pro Ser Thr Leu Val Glu Ile His
            580                 585                 590 

Leu Thr Ala Ala Met Gly Leu Lys Thr Arg Cys Gly Gly Lys Leu Gly
        595                 600                 605 

Phe Leu Ala Ser Tyr Phe Leu Ser Arg Ala Gln Ser Leu Cys Gly Pro
    610                 615                 620 

Glu His Ser Ala Val Pro Asp Ser Leu Arg Trp Leu Cys His Pro Leu
625                 630                 635                 640 

Gly Gln Lys Phe Phe Met Glu Arg Ser Trp Ser Val Lys Ser Ala Ala
                645                 650                 655 

Lys Glu Ser Leu Tyr Cys Ala Gln Arg Asn Pro Ala Asp Pro Ile Ala
            660                 665                 670 

Gln Val His Gln Ala Phe Cys Lys Asn Leu Leu Glu Arg Ala Ile Glu
        675                 680                 685 

Ser Leu Val Lys Pro Gln Ala Lys Lys Lys Ala Gly Asp Gln Glu Glu
    690                 695                 700 

Glu Ser Cys Glu Phe Ser Ser Ala Leu Glu Tyr Leu Lys Leu Leu His
705                 710                 715                 720 

Ser Phe Val Asp Ser Val Gly Val Met Ser Pro Pro Leu Ser Arg Ser
                725                 730                 735 

Ser Val Leu Lys Ser Ala Leu Gly Pro Asp Ile Ile Cys Arg Trp Trp
            740                 745                 750 

Thr Ser Ala Ile Thr Val Ala Ile Ser Trp Leu Gln Gly Asp Asp Ala
        755                 760                 765 

Ala Val Arg Ser His Phe Thr Lys Val Glu Arg Ile Pro Lys Ala Leu
    770                 775                 780 

Glu Val Thr Glu Ser Pro Leu Val Lys Ala Ile Phe His Ala Cys Arg
785                 790                 795                 800 

Ala Met His Ala Ser Leu Pro Gly Lys Ala Asp Gly Gln Gln Ser Ser
                805                 810                 815 

Phe Cys His Cys Glu Arg Ala Ser Gly His Leu Trp Ser Ser Leu Asn
            820                 825                 830 

Val Ser Gly Ala Thr Ser Asp Pro Ala Leu Asn His Val Val Gln Leu
        835                 840                 845 

Leu Thr Cys Asp Leu Leu Leu Ser Leu Arg Thr Ala Leu Trp Gln Lys
    850                 855                 860 

Gln Ala Ser Ala Ser Gln Ala Val Gly Glu Thr Tyr His Ala Ser Gly
865                 870                 875                 880 

Ala Glu Leu Ala Gly Phe Gln Arg Asp Leu Gly Ser Leu Arg Arg Leu
                885                 890                 895 

Ala His Ser Phe Arg Pro Ala Tyr Arg Lys Val Phe Leu His Glu Ala
            900                 905                 910 

Thr Val Arg Leu Met Ala Gly Ala Ser Pro Thr Arg Thr His Gln Leu
        915                 920                 925 

Leu Glu His Ser Leu Arg Arg Arg Thr Thr Gln Ser Thr Lys His Gly
    930                 935                 940 

Glu Val Asp Ala Trp Pro Gly Gln Arg Glu Arg Ala Thr Ala Ile Leu
945                 950                 955                 960 

Leu Ala Cys Arg His Leu Pro Leu Ser Phe Leu Ser Ser Pro Gly Gln
                965                 970                 975 

Arg Ala Val Leu Leu Ala Glu Ala Ala Arg Thr Leu Glu Lys Val Gly
            980                 985                 990 

Asp Arg Arg Ser Cys Asn Asp Cys Gln Gln Met Ile Val Lys Leu Gly
        995                1000                1005 

Gly Gly Thr Ala Ile Ala Ala Ser
   1010                1015    


<210>    2
<211>    3051
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    SREBP2 mRNA


<400>    2
atggacgaca gcggcgagct gggtggtctg gagaccatgg agaccctcac ggagctgggc         60

gacgagctga ccctgggaga catcgacgag atgctgcaat ttgtcagtaa tcaagtggga        120

gagttccctg acttgttttc agaacagctg tgtagctcct ttcctggcag tggtggtagt        180

ggtagcagca gcggcagcag tggcagcagc agcagcagca gcaatggcag gggcagcagc        240

agcggagctg tggacccttc agtgcaacgg tcattcaccc aggtcacatt accttccttc        300

tctccctcgg cggcctcccc acaggctcca actctgcaag tcaaggtttc tcccacctca        360

gttcccacca cacccagggc aactcctatt cttcagcccc gcccccagcc ccagcctcaa        420

cctcaaactc agctgcaaca acagacggta atgatcacgc caacattcag caccactccg        480

cagacgagga tcatccagca gcctttgata taccagaatg cagctactag ctttcaagtc        540

cttcagcctc aagtccaaag cctggtgaca tcctcccagg tacagccggt caccattcag        600

cagcaggtgc agacagtaca ggcccagcgg gtgctgacac aaacggccaa tggcacgctg        660

cagacccttg ccccggctac ggtgcagaca gttgctgcgc cacaggtgca gcaggtcccg        720

gtcctggtcc agcctcagat catcaagaca gattcccttg ttttgaccac actgaagaca        780

gatggcagcc ctgttatggc tgcggtccag aacccggccc tcaccgccct caccacccct        840

atccagacgg ctgcccttca agtaccaacc ctggtgggca gcagtgggac cattctgacc        900

acaatgcctg taatgatggg gcaagagaaa gtgcccatta agcaggtacc tgggggagtc        960

aagcagcttg agccccccaa agaaggagaa aggcggacaa cccataatat cattgagaaa       1020

cgatatcgct cctccatcaa tgacaaaatc atcgaattga aagacctggt catggggaca       1080

gacgccaaga tgcacaagtc tggcgttctg aggaaggcca ttgattacat caaatacttg       1140

cagcaggtca atcataaact gcgccaggag aacatggtgc tgaagctggc aaatcaaaag       1200

aacaagcttc taaagggcat cgacctaggc agtctggtgg acaatgaggt ggacctgaag       1260

atcgaggact ttaatcagaa tgtccttctg atgtcccccc cagcctctga ctcagggtcc       1320

caggctggct tctctcccta ctccattgac tctgagccag gaagccctct attggatgat       1380

gcaaagggag attttgcagc tgctgccggc aacctacaaa cctgcctggc agttttgggc       1440

cgggcactgc ccacctcccg cctggacctg gcctgcagcc tctcctggaa cgtgatccgc       1500

tacagcctgc agaagctacg cctggtgcgc tggctgctca agaaagtctt ccagtgccgg       1560

cgggccacgc cagccactga ggcaggcttt gaagacgaag ctaagaccag cgcccgggat       1620

gcggctctgg cctatcaccg gctgcaccag ctgcacatca cagggaagct tcctgcagga       1680

tccgcctgtt ccgatgtaca catggcgttg tgtgccgtga acctggctga atgtgcagag       1740

gagaagatcc caccgagcac actggttgag atccatctga ctgctgccat ggggctcaag       1800

acccggtgtg gaggcaagct gggcttcctg gccagctact tcctcagccg agcccagagc       1860

ctgtgtggcc ccgagcacag tgctgttcct gactccctgc gctggctctg ccaccccctg       1920

ggccagaagt ttttcatgga gcggagctgg tctgtgaagt cagctgccaa ggagagtcta       1980

tactgtgccc agaggaaccc agctgacccc attgcgcagg tccaccaggc cttctgcaag       2040

aacctgctgg agcgagctat agagtccttg gtgaaacctc aggccaagaa gaaggctgga       2100

gaccaggaag aagagagctg tgaattctcc agtgctctgg agtacttgaa attacttcat       2160

tcttttgtgg actctgtggg ggttatgagc cccccactct ccaggagctc cgtgctcaag       2220

tccgccctgg gtccagacat catctgtcgg tggtggacgt ctgcaatcac tgtggccatc       2280

agctggctcc agggagacga tgcagctgtg cgctctcatt ttaccaaagt ggaacgcatc       2340

cccaaggccc tggaagtgac agagagcccc ctggtgaagg ccatcttcca tgcctgcaga       2400

gccatgcatg cctcactccc tgggaaagca gatgggcagc agagttcctt ctgccattgc       2460

gagagggcca gtggccacct atggagcagc ctcaacgtca gtggggccac ctctgaccct       2520

gccctcaacc acgtggtcca gctgctcacc tgtgacctgc tactgtcgct acggacagcg       2580

ctctggcaaa aacaggccag tgccagccag gctgtggggg agacctacca cgcgtcaggc       2640

gctgaactgg cgggcttcca acgggacctg ggcagcctgc gcaggctggc acacagcttc       2700

cgcccagcat accgcaaggt gttcctgcat gaagccaccg tgcgcctgat ggcaggagcc       2760

agccccaccc gcacccacca gctgctggaa cacagcctgc ggcggcgcac cacgcagagc       2820

accaagcacg gagaggtgga tgcctggccc ggccagcgag agcgggccac cgccatcctg       2880

ctggcctgcc gccacctgcc cctctccttc ctctcctccc cgggccagcg ggcagtgctg       2940

ctggccgaag ctgcccgcac cctggagaag gtgggcgacc ggcgctcctg caacgactgc       3000

cagcagatga ttgttaagct gggtggtggc actgccattg ccgcctcctg a                3051


<210>    3
<211>    378
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SREBP2 C-terminal amino acid sequence


<400>    3
Val Phe Gln Cys Arg Arg Ala Thr Pro Ala Thr Glu Ala Gly Phe Glu
  1               5                  10                  15 

Asp Glu Ala Lys Thr Ser Ala Arg Asp Ala Ala Leu Ala Tyr His Arg
             20                  25                  30 

Leu His Gln Leu His Ile Thr Gly Lys Leu Pro Ala Gly Ser Ala Cys
         35                  40                  45 

Ser Asp Val His Met Ala Leu Cys Ala Val Asn Leu Ala Glu Cys Ala
     50                  55                  60 

Glu Glu Lys Ile Pro Pro Ser Thr Leu Val Glu Ile His Leu Thr Ala
 65                  70                  75                  80 

Ala Met Gly Leu Lys Thr Arg Cys Gly Gly Lys Leu Gly Phe Leu Ala
                 85                  90                  95 

Ser Tyr Phe Leu Ser Arg Ala Gln Ser Leu Cys Gly Pro Glu His Ser
            100                 105                 110 

Ala Val Pro Asp Ser Leu Arg Trp Leu Cys His Pro Leu Gly Gln Lys
        115                 120                 125 

Phe Phe Met Glu Arg Ser Trp Ser Val Lys Ser Ala Ala Lys Glu Ser
    130                 135                 140 

Leu Tyr Cys Ala Gln Arg Asn Pro Ala Asp Pro Ile Ala Gln Val His
145                 150                 155                 160 

Gln Ala Phe Cys Lys Asn Leu Leu Glu Arg Ala Ile Glu Ser Leu Val
                165                 170                 175 

Lys Pro Gln Ala Lys Lys Lys Ala Gly Asp Gln Glu Glu Glu Ser Cys
            180                 185                 190 

Glu Phe Ser Ser Ala Leu Glu Tyr Leu Lys Leu Leu His Ser Phe Val
        195                 200                 205 

Asp Ser Val Gly Val Met Ser Pro Pro Leu Ser Arg Ser Ser Val Leu
    210                 215                 220 

Lys Ser Ala Leu Gly Pro Asp Ile Ile Cys Arg Trp Trp Thr Ser Ala
225                 230                 235                 240 

Ile Thr Val Ala Ile Ser Trp Leu Gln Gly Asp Asp Ala Ala Val Arg
                245                 250                 255 

Ser His Phe Thr Lys Val Glu Arg Ile Pro Lys Ala Leu Glu Val Thr
            260                 265                 270 

Glu Ser Pro Leu Val Lys Ala Ile Phe His Ala Cys Arg Ala Met His
        275                 280                 285 

Ala Ser Leu Pro Gly Lys Ala Asp Gly Gln Gln Ser Ser Phe Cys His
    290                 295                 300 

Cys Glu Arg Ala Ser Gly His Leu Trp Ser Ser Leu Asn Val Ser Gly
305                 310                 315                 320 

Ala Thr Ser Asp Pro Ala Leu Asn His Val Val Gln Leu Leu Thr Cys
                325                 330                 335 

Asp Leu Leu Leu Ser Leu Arg Thr Ala Leu Trp Gln Lys Gln Ala Ser
            340                 345                 350 

Ala Ser Gln Ala Val Gly Glu Thr Tyr His Ala Ser Gly Ala Glu Leu
        355                 360                 365 

Ala Gly Phe Gln Arg Asp Leu Gly Ser Leu
    370                 375            
