                         SEQUENCE LISTING

<110>  ASTELLAS PHARMA, INC.
 
<120>  HUMAN NON-NATURALLY OCCURRING MODIFIED FC REGION OF IGG 
SPECIFICALLY BINDING TO NON-NATURALLY OCCURRING MODIFIED FC RECEPTOR

<130>  127206-07820

<150>  63/067,629
<151>  2020-08-19

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  1
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga aag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  2
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  3
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K120D_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  3
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac gat gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Asp Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga aag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  4
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Asp Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  5
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K120E_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  5
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac gag gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Glu Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga aag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  6
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Glu Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  7
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K128D_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  7
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc gat ggc aga aag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Asp Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  8
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Asp Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  9
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K128E_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  9
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc gag ggc aga aag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Glu Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  10
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Glu Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  11
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K131D_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  11
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga gat tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  12
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  13
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K131E_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  13
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga gag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Glu Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  14
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Glu Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  15
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K161D_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  15
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga aag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc gat aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Asp Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  16
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Asp Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  17
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K161E_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  17
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga aag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc gag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Glu Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  18
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Glu Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  19
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal sequence


<220>
<221>  CDS
<222>  (1)..(57)

<400>  19
atg gaa ttt ggc ctg tcc tgg gtg ttc ctg gtg gcc att ctg aaa ggc         48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly           
1               5                   10                  15                

gtg cag tgc                                                             57
Val Gln Cys                                                               
                                                                          


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  21
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Trastuzumab_VH_1


<220>
<221>  CDS
<222>  (1)..(360)

<400>  21
gag gtg cag ctg gtt gaa tct ggc gga gga ttg gtt cag cct ggc ggc         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct ctg aga ctg tct tgt gcc gcc tct ggc ttc aac atc aag gac acc         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr           
            20                  25                  30                    

tac atc cac tgg gtc cga cag gcc cct ggc aaa gga ttg gaa tgg gtc        144
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gcc aga atc tac ccc acc aac ggc tac acc aga tac gcc gac tct gtg        192
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc aga ttc acc atc tcc gcc gac acc tcc aag aac acc gcc tac        240
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atg aac tcc ctg aga gcc gag gac acc gcc gtg tac tac tgc        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

tct aga tgg gga ggc gac ggc ttc tac gcc atg gat tat tgg ggc cag        336
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc ctg gtc acc gtt agt tct                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  22
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_wt (CH_IgG1)


<220>
<221>  CDS
<222>  (1)..(993)

<400>  23
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gat gtg tct cac gag gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gaa cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  24
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  25
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal sequence


<220>
<221>  CDS
<222>  (1)..(66)

<400>  25
atg gat atg aga gtg ccc gct cag ctg ctg gga ctg ctg ctg ttg tgg         48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp           
1               5                   10                  15                

ttg aga ggc gcc aga tgc                                                 66
Leu Arg Gly Ala Arg Cys                                                   
            20                                                            


<210>  26
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  27
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Trastuzumab_Light Chain


<220>
<221>  CDS
<222>  (1)..(645)

<400>  27
gac atc cag atg acc cag tct cca tcc tct ctg tcc gcc tct gtg ggc         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtg acc atc acc tgt aga gcc agc cag gac gtg aac acc gcc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala           
            20                  25                  30                    

gtg gct tgg tat cag cag aag cct ggc aag gcc cct aag ctg ctg atc        144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tac tcc gcc tcc ttc ctg tac tct ggc gtg ccc tct aga ttc tcc ggc        192
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

tct aga tct ggc acc gac ttt acc ctg aca atc tcc agc ctg cag cct        240
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gag gac ttc gcc acc tac tac tgc cag cag cac tac acc aca cct cca        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro           
                85                  90                  95                

acc ttt ggc cag ggc acc aag gtg gaa atc aag cgt acg gtg gcc gct        336
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala           
            100                 105                 110                   

cct tcc gtg ttc atc ttc cca cct tcc gac gag cag ctg aag tcc ggc        384
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly           
        115                 120                 125                       

aca gct tct gtc gtg tgc ctg ctg aac aac ttc tac cct cgg gaa gcc        432
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala           
    130                 135                 140                           

aag gtg cag tgg aag gtg gac aat gcc ctg cag tcc ggc aac tcc caa        480
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln           
145                 150                 155                 160           

gag tct gtg acc gag cag gac tcc aag gac agc acc tac agc ctg tcc        528
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser           
                165                 170                 175               

tcc aca ctg acc ctg tcc aag gcc gac tac gag aag cac aag gtg tac        576
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr           
            180                 185                 190                   

gcc tgc gaa gtg acc cat cag ggc ctg tct agc cct gtg acc aag tct        624
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser           
        195                 200                 205                       

ttc aac cgg ggc gag tgc tga                                            645
Phe Asn Arg Gly Glu Cys                                                   
    210                                                                   


<210>  28
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  29
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_E294K


<220>
<221>  CDS
<222>  (1)..(993)

<400>  29
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gat gtg tct cac gag gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

aag cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Lys Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  30
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Lys Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  31
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_E294R


<220>
<221>  CDS
<222>  (1)..(993)

<400>  31
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gat gtg tct cac gag gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

aga cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Arg Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  32
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Arg Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  33
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_S239K


<220>
<221>  CDS
<222>  (1)..(993)

<400>  33
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct aag gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Lys Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gat gtg tct cac gag gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gaa cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  34
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Lys Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  35
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_S239R


<220>
<221>  CDS
<222>  (1)..(993)

<400>  35
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct aga gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Arg Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gat gtg tct cac gag gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gaa cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  36
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Arg Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  37
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal sequence


<220>
<221>  CDS
<222>  (1)..(57)

<400>  37
atg gaa tgg tcc tgg gtg ttc ctg ttc ttc ctg tcc gtg acc acc ggc         48
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly           
1               5                   10                  15                

gtg cac tct                                                             57
Val His Ser                                                               
                                                                          


<210>  38
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  39
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Trastuzumab_VH_2


<220>
<221>  CDS
<222>  (1)..(360)

<400>  39
gaa gtg cag ctg gtt gaa tct ggc ggc gga ttg gtt cag cct ggc gga         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct ctg aga ctg tct tgt gcc gcc tcc ggc ttc aac atc aag gac acc         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr           
            20                  25                  30                    

tac atc cac tgg gtc cga cag gcc cct ggc aaa gga ttg gaa tgg gtc        144
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gcc aga atc tac ccc acc aac ggc tac acc aga tac gcc gac tct gtg        192
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc aga ttc acc atc tcc gcc gac acc tcc aag aac acc gcc tac        240
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atg aac tcc ctg aga gcc gag gac acc gcc gtg tac tac tgc        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

tct aga tgg gga ggc gac ggc ttc tac gcc atg gat tat tgg ggc cag        336
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc ctg gtc acc gtt tct tcc                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  40
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  41
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_D265K


<220>
<221>  CDS
<222>  (1)..(993)

<400>  41
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg aag gtg tct cac gag gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Lys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gaa cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  42
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Lys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  43
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_D265R


<220>
<221>  CDS
<222>  (1)..(993)

<400>  43
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg aga gtg tct cac gag gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Arg Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gaa cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  44
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Arg Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  45
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_E269K


<220>
<221>  CDS
<222>  (1)..(993)

<400>  45
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gat gtg tct cac aag gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Asp Val Ser His Lys Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gaa cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  46
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Lys Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  47
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_E269R


<220>
<221>  CDS
<222>  (1)..(993)

<400>  47
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gat gtg tct cac aga gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gaa cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  48
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  49
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K128E_K131D_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  49
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc gag ggc aga gat tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Glu Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  50
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Glu Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  51
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K128E_K131E_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  51
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc gag ggc aga gag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Glu Gly Arg Glu Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  52
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Glu Gly Arg Glu Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  53
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K131D_N38Q_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  53
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac cag tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Gln Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga gat tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  54
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Gln Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  55
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K131D_N74Q_FLAG


<220>
<221>  CDS
<222>  (1)..(651)

<400>  55
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc cag ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Gln Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga gat tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gac tac aag gac gac gac gac aag tga                                    651
Asp Tyr Lys Asp Asp Asp Asp Lys                                           
    210                 215                                               


<210>  56
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Gln Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Asp Tyr Lys Asp Asp Asp Asp Lys 
    210                 215     


<210>  57
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_E269R_E294K


<220>
<221>  CDS
<222>  (1)..(993)

<400>  57
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gat gtg tct cac aga gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

aag cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Lys Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  58
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Lys Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  59
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Fc_E269R_E294R


<220>
<221>  CDS
<222>  (1)..(993)

<400>  59
gct agc acc aag gga ccc agc gtg ttc cct ctg gct cct agc tct aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

tcc acc tct ggc gga aca gct gct ctg ggc tgt ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gct ctg aca tct        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac aca ttc cct gct gtg ctg cag tcc tcc ggc ctg tac tct        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctg tcc tct gtc gtg acc gtg cct tcc agc tct ctg gga acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aat gtg aac cac aag cct tcc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca tgt        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gat gtg tct cac aga gac cca gaa gtg aag ttc aat tgg        480
Val Val Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

aga cag tac aac tcc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg        576
Arg Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gcc aag ggc        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag cct agg gaa ccc cag gtt tac acc ttg cct cca tct cgg gac gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg aag ggc ttc tac        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctg tac tcc aag ctg aca gtg gat aag tcc cgg tgg cag cag ggc aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtg ttc tct tgc tct gtg atg cac gag gcc ctg cac aac cac tac aca        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag tct ctg tct ctg agc ccc ggc aag tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  60
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Arg Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  61
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal sequence


<220>
<221>  CDS
<222>  (1)..(57)

<400>  61
atg gaa ttt ggc ctg tcc tgg gtg ttc ctg gtg gct ctg ttg aga ggc         48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly           
1               5                   10                  15                

gtg cag tgt                                                             57
Val Gln Cys                                                               
                                                                          


<210>  62
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  63
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Cetuximab VH


<220>
<221>  CDS
<222>  (1)..(357)

<400>  63
cag gtg cag ctg aag cag tct gga cct gga ctg gtg cag cct tct cag         48
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln           
1               5                   10                  15                

tcc ctg tcc atc acc tgt acc gtg tcc ggc ttc tcc ctg acc aat tac         96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr           
            20                  25                  30                    

ggc gtg cac tgg gtc cga cag tct cca ggc aaa gga ctg gaa tgg ctg        144
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu           
        35                  40                  45                        

gga gtg att tgg agc ggc ggc aac acc gac tac aac acc cct ttc acc        192
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr           
    50                  55                  60                            

tct cgg ctg agc atc aac aag gac aac tcc aag agc cag gtg ttc ttc        240
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe           
65                  70                  75                  80            

aag atg aac tcc ctg cag tcc aac gac acc gcc atc tac tac tgc gct        288
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala           
                85                  90                  95                

aga gcc ctg acc tac tac gac tac gag ttc gcc tat tgg ggc cag ggc        336
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly           
            100                 105                 110                   

aca ctg gtc aca gtt tcc gct                                            357
Thr Leu Val Thr Val Ser Ala                                               
        115                                                               


<210>  64
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  65
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal sequence


<220>
<221>  CDS
<222>  (1)..(57)

<400>  65
atg ttg cct tct cag ctg atc ggc ttc ctg ctg ctg tgg gtg cca gct         48
Met Leu Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala           
1               5                   10                  15                

tct aga ggc                                                             57
Ser Arg Gly                                                               
                                                                          


<210>  66
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Met Leu Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly 
            


<210>  67
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Cetuximab_Light Chain


<220>
<221>  CDS
<222>  (1)..(645)

<400>  67
gac atc ctg ctg acc cag tct cca gtg atc ctg tcc gtg tct cct ggc         48
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly           
1               5                   10                  15                

gag aga gtg tcc ttc agc tgc aga gcc tct cag tcc atc ggc acc aac         96
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn           
            20                  25                  30                    

atc cac tgg tat cag cag cgg acc aac ggc tcc cct cgg ctg ctg att        144
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile           
        35                  40                  45                        

aag tac gcc tcc gag tct atc agc ggc atc ccc tcc aga ttc tcc ggc        192
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

tct ggc tct ggc acc gac ttc acc ctg tcc atc aac tcc gtg gaa tcc        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser           
65                  70                  75                  80            

gag gat atc gcc gac tac tac tgc cag cag aac aac aac tgg ccc acc        288
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr           
                85                  90                  95                

acc ttt ggc gct ggc acc aag ctg gaa ctg aag cgt acg gtg gct gcc        336
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala           
            100                 105                 110                   

cct tcc gtg ttc atc ttc cca cct tcc gac gaa cag ctg aag tcc ggc        384
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly           
        115                 120                 125                       

aca gcc tct gtc gtg tgc ctg ctg aac aac ttc tac cct cgg gaa gcc        432
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala           
    130                 135                 140                           

aag gtg cag tgg aag gtg gac aat gcc ctg cag tcc ggc aac tcc caa        480
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln           
145                 150                 155                 160           

gag tct gtg acc gag cag gac tcc aag gac agc acc tac agc ctg tcc        528
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser           
                165                 170                 175               

tcc aca ctg acc ctg agc aag gcc gac tac gag aag cac aag gtg tac        576
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr           
            180                 185                 190                   

gcc tgc gaa gtg acc cat cag ggc ctg tct agc cct gtg acc aag tct        624
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser           
        195                 200                 205                       

ttc aac cgg ggc gag tgc tga                                            645
Phe Asn Arg Gly Glu Cys                                                   
    210                                                                   


<210>  68
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  69
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal sequence


<220>
<221>  CDS
<222>  (1)..(57)

<400>  69
atg gaa tgg tct tgg gtg ttc ctg ttc ttc ctg tcc gtg acc acc ggc         48
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly           
1               5                   10                  15                

gtg cac tct                                                             57
Val His Ser                                                               
                                                                          


<210>  70
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  71
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Edrecolomab_VH


<220>
<221>  CDS
<222>  (1)..(348)

<400>  71
cag gtt cag ttg cag cag tct ggc gcc gaa ctc gtc aga cct ggc aca         48
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr           
1               5                   10                  15                

tct gtg aag gtg tcc tgc aag gcc tct ggc tac gcc ttc acc aac tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr           
            20                  25                  30                    

ctg atc gag tgg gtc aag cag agg cct gga cag gga ctc gag tgg atc        144
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggc gtt atc aat cct ggc tct ggc ggc acc aat tac aac gag aag ttc        192
Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aag ggc aaa gct acc ctg acc gcc gac aag tcc tct tcc acc gct tac        240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg cag ctg tcc agc ctg acc tct gac gac tcc gcc gtg tac ttc tgt        288
Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys           
                85                  90                  95                

gcc aga gat ggc cct tgg ttt gcc tat tgg ggc cag ggc aca ctg gtc        336
Ala Arg Asp Gly Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val           
            100                 105                 110                   

acc gtt tct gct                                                        348
Thr Val Ser Ala                                                           
        115                                                               


<210>  72
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  73
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal sequence


<220>
<221>  CDS
<222>  (1)..(60)

<400>  73
atg tct gtg cct aca cag gtt ctg gga ctg ctg ctg ctg tgg ctg acc         48
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr           
1               5                   10                  15                

gac gcc aga tgc                                                         60
Asp Ala Arg Cys                                                           
            20                                                            


<210>  74
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  75
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding edrecolomab_Light Chain


<220>
<221>  CDS
<222>  (1)..(645)

<400>  75
aac atc gtg atg acc cag tct cca aag tcc atg tcc atg agc gtg ggc         48
Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly           
1               5                   10                  15                

gag aga gtg acc ctg acc tgc aag gcc tct gag aac gtg gtc acc tac         96
Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr           
            20                  25                  30                    

gtg tcc tgg tat cag cag aag ccc gag cag tcc cct aag ctg ctg atc        144
Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile           
        35                  40                  45                        

tac ggc gcc tct aac aga tac acc ggc gtg ccc gat aga ttc acc ggc        192
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly           
    50                  55                  60                            

tct ggc tct gcc acc gac ttt acc ctg acc atc agc tct gtg cag gcc        240
Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala           
65                  70                  75                  80            

gag gat ctg gcc gat tac cat tgt ggc cag ggc tac agc tac ccc tac        288
Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr           
                85                  90                  95                

aca ttt ggc gga ggc acc aag ctg gaa atc aag cgt acg gtg gcc gct        336
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala           
            100                 105                 110                   

cct tcc gtg ttc atc ttc cca cct tcc gac gag cag ctg aag tct ggc        384
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly           
        115                 120                 125                       

aca gcc tct gtc gtg tgc ctg ctg aac aac ttc tac cct cgg gaa gcc        432
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala           
    130                 135                 140                           

aag gtg cag tgg aag gtg gac aat gcc ctg cag tcc ggc aac tcc caa        480
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln           
145                 150                 155                 160           

gag tct gtg acc gag cag gac tcc aag gac agc acc tac agc ctg tcc        528
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser           
                165                 170                 175               

tcc aca ctg acc ctg tcc aag gcc gac tac gag aag cac aag gtg tac        576
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr           
            180                 185                 190                   

gcc tgc gaa gtg acc cat cag ggc ctg tct agc cct gtg acc aag tct        624
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser           
        195                 200                 205                       

ttc aac cgg ggc gag tgc tga                                            645
Phe Asn Arg Gly Glu Cys                                                   
    210                                                                   


<210>  76
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  77
<211>  711
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(711)

<400>  77
aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct cag tgg         48
Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp           
1               5                   10                  15                

tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag ggc gct         96
Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala           
            20                  25                  30                    

tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag tcc ctg        144
Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu           
        35                  40                  45                        

atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc gtg gac        192
Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp           
    50                  55                  60                            

gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg agc gat        240
Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp           
65                  70                  75                  80            

cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag gcc cct        288
Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro           
                85                  90                  95                

aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc cac tct        336
Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser           
            100                 105                 110                   

tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac ggc aag        384
Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys           
        115                 120                 125                       

ggc aga aag tac ttc cac cac aac tcc gac ttc tac atc ccc aag gct        432
Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala           
    130                 135                 140                           

acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg ggc tcc        480
Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser           
145                 150                 155                 160           

aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag ggc ctc        528
Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu           
                165                 170                 175               

gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag gtc tct        576
Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser           
            180                 185                 190                   

ttc tgc ttg gtg atg gta ctc ctt ttt gca gtg gac aca gga cta tat        624
Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr           
        195                 200                 205                       

ttc tct gtg aag aca aac att cga agc tca aca aga gac tgg aag gac        672
Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp           
    210                 215                 220                           

cat aaa ttt aaa tgg aga aag gac cct caa gac aaa tga                    711
His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys                           
225                 230                 235                               


<210>  78
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  78

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp 
    210                 215                 220                 


His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
225                 230                 235     


<210>  79
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K131D Full


<220>
<221>  CDS
<222>  (1)..(765)

<400>  79
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga gat tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gtc tct ttc tgc ttg gtg atg gta ctc ctt ttt gca gtg gac aca gga        672
Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly           
    210                 215                 220                           

cta tat ttc tct gtg aag aca aac att cga agc tca aca aga gac tgg        720
Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp           
225                 230                 235                 240           

aag gac cat aaa ttt aaa tgg aga aag gac cct caa gac aaa tga            765
Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys                   
                245                 250                                   


<210>  80
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  81
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K128E_K131D Full


<220>
<221>  CDS
<222>  (1)..(765)

<400>  81
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc gag ggc aga gat tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Glu Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gtc tct ttc tgc ttg gtg atg gta ctc ctt ttt gca gtg gac aca gga        672
Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly           
    210                 215                 220                           

cta tat ttc tct gtg aag aca aac att cga agc tca aca aga gac tgg        720
Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp           
225                 230                 235                 240           

aag gac cat aaa ttt aaa tgg aga aag gac cct caa gac aaa tga            765
Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys                   
                245                 250                                   


<210>  82
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Glu Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  83
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K128E_K131E Full


<220>
<221>  CDS
<222>  (1)..(765)

<400>  83
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc gag ggc aga gag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Glu Gly Arg Glu Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gtc tct ttc tgc ttg gtg atg gta ctc ctt ttt gca gtg gac aca gga        672
Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly           
    210                 215                 220                           

cta tat ttc tct gtg aag aca aac att cga agc tca aca aga gac tgg        720
Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp           
225                 230                 235                 240           

aag gac cat aaa ttt aaa tgg aga aag gac cct caa gac aaa tga            765
Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys                   
                245                 250                                   


<210>  84
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Glu Gly Arg Glu Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  85
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K131D_N38Q Full


<220>
<221>  CDS
<222>  (1)..(765)

<400>  85
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac cag tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Gln Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga gat tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gtc tct ttc tgc ttg gtg atg gta ctc ctt ttt gca gtg gac aca gga        672
Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly           
    210                 215                 220                           

cta tat ttc tct gtg aag aca aac att cga agc tca aca aga gac tgg        720
Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp           
225                 230                 235                 240           

aag gac cat aaa ttt aaa tgg aga aag gac cct caa gac aaa tga            765
Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys                   
                245                 250                                   


<210>  86
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Gln Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  87
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding CD16A_V158_K131D_N74Q Full


<220>
<221>  CDS
<222>  (1)..(765)

<400>  87
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc cag ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Gln Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga gat tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gtc tct ttc tgc ttg gtg atg gta ctc ctt ttt gca gtg gac aca gga        672
Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly           
    210                 215                 220                           

cta tat ttc tct gtg aag aca aac att cga agc tca aca aga gac tgg        720
Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp           
225                 230                 235                 240           

aag gac cat aaa ttt aaa tgg aga aag gac cct caa gac aaa tga            765
Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys                   
                245                 250                                   


<210>  88
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Gln Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  89
<211>  765
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(765)

<400>  89
atg tgg cag ctg ctg ctg cct aca gct ctg ctg ctg ttg gtg tct gcc         48
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala           
1               5                   10                  15                

ggc atg aga acc gag gat ctg cct aag gcc gtg gtg ttc ctg gaa cct         96
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro           
            20                  25                  30                    

cag tgg tac aga gtg ctg gaa aag gac agc gtg acc ctg aag tgc cag        144
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln           
        35                  40                  45                        

ggc gct tac tct ccc gag gac aac tct acc cag tgg ttc cac aac gag        192
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu           
    50                  55                  60                            

tcc ctg atc tcc agc cag gcc tcc tcc tac ttt atc gat gcc gcc acc        240
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr           
65                  70                  75                  80            

gtg gac gac tct ggc gag tat aga tgc cag acc aac ctg agc acc ctg        288
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu           
                85                  90                  95                

agc gat cct gtg cag ctg gaa gtg cat atc ggc tgg ctg ttg ctg cag        336
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln           
            100                 105                 110                   

gcc cct aga tgg gtg ttc aaa gaa gag gac ccc atc cac ctg aga tgc        384
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys           
        115                 120                 125                       

cac tct tgg aag aac acc gct ctg cac aaa gtg acc tac ctg cag aac        432
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn           
    130                 135                 140                           

ggc aag ggc aga aag tac ttc cac cac aac tcc gac ttc tac atc ccc        480
Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro           
145                 150                 155                 160           

aag gct acc ctg aag gac tcc ggc tcc tac ttc tgt aga ggc ctc gtg        528
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val           
                165                 170                 175               

ggc tcc aag aac gtg tcc tcc gag aca gtg aac atc acc atc aca cag        576
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln           
            180                 185                 190                   

ggc ctc gcc gtg tct acc atc tcc agc ttt ttc cca cct ggc tac cag        624
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln           
        195                 200                 205                       

gtc tct ttc tgc ttg gtg atg gta ctc ctt ttt gca gtg gac aca gga        672
Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly           
    210                 215                 220                           

cta tat ttc tct gtg aag aca aac att cga agc tca aca aga gac tgg        720
Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp           
225                 230                 235                 240           

aag gac cat aaa ttt aaa tgg aga aag gac cct caa gac aaa tga            765
Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys                   
                245                 250                                   


<210>  90
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG

<400>  91

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  92
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD16A_V158_8BBz


<220>
<221>  CDS
<222>  (1)..(1311)

<400>  92
atg gct ctg cct gtt aca gct ctg ctg ctg cct ctg gct ctg ctt ctg         48
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu           
1               5                   10                  15                

cat gct gcc aga cct ggc atg aga acc gag gat ctg cct aag gcc gtg         96
His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val           
            20                  25                  30                    

gtg ttc ctg gaa cct cag tgg tac aga gtg ctg gaa aag gac agc gtg        144
Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val           
        35                  40                  45                        

acc ctg aag tgc cag ggc gcc tat tct ccc gag gac aat agc acc cag        192
Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln           
    50                  55                  60                            

tgg ttc cac aac gag agc ctg atc agc agc cag gcc agc agc tac ttt        240
Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe           
65                  70                  75                  80            

atc gat gcc gcc acc gtg gac gac agc ggc gag tac aga tgc cag acc        288
Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr           
                85                  90                  95                

aat ctg agc acc ctg agc gac cct gtg cag ctg gaa gtg cac att gga        336
Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly           
            100                 105                 110                   

tgg ctg ctg ctt cag gcc cct aga tgg gtg ttc aaa gaa gag gac ccc        384
Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro           
        115                 120                 125                       

atc cac ctg aga tgc cac tct tgg aag aac aca gcc ctg cac aaa gtg        432
Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val           
    130                 135                 140                           

acc tac ctg cag aac ggc aag ggc aga aag tac ttc cac cac aac agc        480
Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser           
145                 150                 155                 160           

gac ttc tac atc ccc aag gcc aca ctg aag gac tcc ggc tcc tac ttc        528
Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe           
                165                 170                 175               

tgt aga ggc ctc gtg ggc agc aag aac gtg tcc agc gag aca gtg aac        576
Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn           
            180                 185                 190                   

atc acc atc aca cag ggc ctc gcc gtg tct acc atc agc agc ttt ttc        624
Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe           
        195                 200                 205                       

cca cct ggc tac cag acc acc aca cca gct cct aga cct cca act cct        672
Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro           
    210                 215                 220                           

gct cca aca atc gcc agc cag cct ctg tct ctg agg cca gaa gct tgt        720
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys           
225                 230                 235                 240           

aga cct gct gct ggc gga gcc gtg cat aca aga gga ctg gat ttc gcc        768
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala           
                245                 250                 255               

tgc gat atc tac atc tgg gcc cct ctg gct ggc aca tgt ggc gtt ctg        816
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu           
            260                 265                 270                   

ctg ctc agc ctg gtc atc acc ctg tac tgc aag aga ggc cgc aag aag        864
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys           
        275                 280                 285                       

ctg ctg tac atc ttc aag cag ccc ttc atg cgg ccc gtg cag acc aca        912
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr           
    290                 295                 300                           

caa gag gaa gat ggc tgc agc tgt cgg ttc ccc gag gaa gaa gaa ggc        960
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly           
305                 310                 315                 320           

ggc tgc gag ctg aga gtg aag ttc agc aga tcc gcc gac gct cct gcc       1008
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala           
                325                 330                 335               

tat cag cag gga cag aac cag ctg tac aac gag ctg aac ctg ggg aga       1056
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg           
            340                 345                 350                   

aga gaa gag tac gac gtg ctg gac aag cgg aga ggc aga gat cct gag       1104
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu           
        355                 360                 365                       

atg ggc ggc aag ccc aga cgg aag aat cct caa gag ggc ctg tat aat       1152
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn           
    370                 375                 380                           

gag ctg cag aaa gac aag atg gcc gag gcc tac agc gag atc gga atg       1200
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met           
385                 390                 395                 400           

aag ggc gag cgc aga aga ggc aag gga cac gat gga ctg tac cag ggc       1248
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly           
                405                 410                 415               

ctg agc acc gcc acc aag gat acc tat gac gca ctg cac atg cag gcc       1296
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala           
            420                 425                 430                   

ctg cct cca aga taa                                                   1311
Leu Pro Pro Arg                                                           
        435                                                               


<210>  93
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  93

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  94
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD16A_V158_K131D 8BBz


<220>
<221>  CDS
<222>  (1)..(1311)

<400>  94
atg gct ctg cct gtt aca gct ctg ctg ctg cct ctg gct ctg ctt ctg         48
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu           
1               5                   10                  15                

cat gct gcc aga cct ggc atg aga acc gag gat ctg cct aag gcc gtg         96
His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val           
            20                  25                  30                    

gtg ttc ctg gaa cct cag tgg tac aga gtg ctg gaa aag gac agc gtg        144
Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val           
        35                  40                  45                        

acc ctg aag tgc cag ggc gcc tat tct ccc gag gac aat agc acc cag        192
Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln           
    50                  55                  60                            

tgg ttc cac aac gag agc ctg atc agc agc cag gcc agc agc tac ttt        240
Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe           
65                  70                  75                  80            

atc gat gcc gcc acc gtg gac gac agc ggc gag tac aga tgc cag acc        288
Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr           
                85                  90                  95                

aat ctg agc acc ctg agc gac cct gtg cag ctg gaa gtg cac att gga        336
Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly           
            100                 105                 110                   

tgg ctg ctg ctt cag gcc cct aga tgg gtg ttc aaa gaa gag gac ccc        384
Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro           
        115                 120                 125                       

atc cac ctg aga tgc cac tct tgg aag aac aca gcc ctg cac aaa gtg        432
Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val           
    130                 135                 140                           

acc tac ctg cag aac ggc aag ggc aga gac tac ttc cac cac aac agc        480
Thr Tyr Leu Gln Asn Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser           
145                 150                 155                 160           

gac ttc tac atc ccc aag gcc aca ctg aag gac tcc ggc tcc tac ttc        528
Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe           
                165                 170                 175               

tgt aga ggc ctc gtg ggc agc aag aac gtg tcc agc gag aca gtg aac        576
Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn           
            180                 185                 190                   

atc acc atc aca cag ggc ctc gcc gtg tct acc atc agc agc ttt ttc        624
Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe           
        195                 200                 205                       

cca cct ggc tac cag acc acc aca cca gct cct aga cct cca act cct        672
Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro           
    210                 215                 220                           

gct cca aca atc gcc agc cag cct ctg tct ctg agg cca gaa gct tgt        720
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys           
225                 230                 235                 240           

aga cct gct gct ggc gga gcc gtg cat aca aga gga ctg gat ttc gcc        768
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala           
                245                 250                 255               

tgc gat atc tac atc tgg gcc cct ctg gct ggc aca tgt ggc gtt ctg        816
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu           
            260                 265                 270                   

ctg ctc agc ctg gtc atc acc ctg tac tgc aag cgg ggc aga aag aaa        864
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys           
        275                 280                 285                       

ctg ctg tac atc ttc aag cag ccc ttc atg cgg ccc gtg cag acc aca        912
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr           
    290                 295                 300                           

caa gag gaa gat ggc tgc agc tgt cgg ttc ccc gag gaa gaa gaa ggc        960
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly           
305                 310                 315                 320           

ggc tgc gag ctg aga gtg aag ttc agc aga tcc gcc gac gct cct gcc       1008
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala           
                325                 330                 335               

tat cag cag gga cag aac cag ctg tac aac gag ctg aac ctg ggg aga       1056
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg           
            340                 345                 350                   

aga gaa gag tac gac gtg ctg gac aag cgg aga ggc aga gat cct gag       1104
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu           
        355                 360                 365                       

atg ggc ggc aag ccc aga cgg aag aat cct caa gag ggc ctg tat aat       1152
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn           
    370                 375                 380                           

gag ctg cag aaa gac aag atg gcc gag gcc tac agc gag atc gga atg       1200
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met           
385                 390                 395                 400           

aag ggc gag cgc aga aga ggc aag gga cac gat gga ctg tac cag ggc       1248
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly           
                405                 410                 415               

ctg agc acc gcc acc aag gat acc tat gac gca ctg cac atg cag gcc       1296
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala           
            420                 425                 430                   

ctg cct cca aga taa                                                   1311
Leu Pro Pro Arg                                                           
        435                                                               


<210>  95
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  95

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  96
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD16A_V158_K128E_K131D 8BBz


<220>
<221>  CDS
<222>  (1)..(1311)

<400>  96
atg gct ctg cct gtt aca gct ctg ctg ctg cct ctg gct ctg ctt ctg         48
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu           
1               5                   10                  15                

cat gct gcc aga cct ggc atg aga acc gag gat ctg cct aag gcc gtg         96
His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val           
            20                  25                  30                    

gtg ttc ctg gaa cct cag tgg tac aga gtg ctg gaa aag gac agc gtg        144
Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val           
        35                  40                  45                        

acc ctg aag tgc cag ggc gcc tat tct ccc gag gac aat agc acc cag        192
Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln           
    50                  55                  60                            

tgg ttc cac aac gag agc ctg atc agc agc cag gcc agc agc tac ttt        240
Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe           
65                  70                  75                  80            

atc gat gcc gcc acc gtg gac gac agc ggc gag tac aga tgc cag acc        288
Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr           
                85                  90                  95                

aat ctg agc acc ctg agc gac cct gtg cag ctg gaa gtg cac att gga        336
Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly           
            100                 105                 110                   

tgg ctg ctg ctt cag gcc cct aga tgg gtg ttc aaa gaa gag gac ccc        384
Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro           
        115                 120                 125                       

atc cac ctg aga tgc cac tct tgg aag aac aca gcc ctg cac aaa gtg        432
Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val           
    130                 135                 140                           

acc tac ctg cag aac ggc gag ggc aga gac tac ttc cac cac aac agc        480
Thr Tyr Leu Gln Asn Gly Glu Gly Arg Asp Tyr Phe His His Asn Ser           
145                 150                 155                 160           

gac ttc tac atc ccc aag gcc aca ctg aag gac tcc ggc tcc tac ttc        528
Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe           
                165                 170                 175               

tgt aga ggc ctc gtg ggc agc aag aac gtg tcc agc gag aca gtg aac        576
Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn           
            180                 185                 190                   

atc acc atc aca cag ggc ctc gcc gtg tct acc atc agc agc ttt ttc        624
Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe           
        195                 200                 205                       

cca cct ggc tac cag acc acc aca cca gct cct aga cct cca act cct        672
Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro           
    210                 215                 220                           

gct cca aca atc gcc agc cag cct ctg tct ctg agg cca gaa gct tgt        720
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys           
225                 230                 235                 240           

aga cct gct gct ggc gga gcc gtg cat aca aga gga ctg gat ttc gcc        768
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala           
                245                 250                 255               

tgc gat atc tac atc tgg gcc cct ctg gct ggc aca tgt ggc gtt ctg        816
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu           
            260                 265                 270                   

ctg ctc agc ctg gtc atc acc ctg tac tgc aag cgg ggc aga aag aaa        864
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys           
        275                 280                 285                       

ctg ctg tac atc ttc aag cag ccc ttc atg cgg ccc gtg cag acc aca        912
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr           
    290                 295                 300                           

caa gag gaa gat ggc tgc agc tgt cgg ttc ccc gag gaa gaa gaa ggc        960
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly           
305                 310                 315                 320           

ggc tgc gag ctg aga gtg aag ttc agc aga tcc gcc gac gct cct gcc       1008
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala           
                325                 330                 335               

tat cag cag gga cag aac cag ctg tac aac gag ctg aac ctg ggg aga       1056
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg           
            340                 345                 350                   

aga gaa gag tac gac gtg ctg gac aag cgg aga ggc aga gat cct gag       1104
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu           
        355                 360                 365                       

atg ggc ggc aag ccc aga cgg aag aat cct caa gag ggc ctg tat aat       1152
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn           
    370                 375                 380                           

gag ctg cag aaa gac aag atg gcc gag gcc tac agc gag atc gga atg       1200
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met           
385                 390                 395                 400           

aag ggc gag cgc aga aga ggc aag gga cac gat gga ctg tac cag ggc       1248
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly           
                405                 410                 415               

ctg agc acc gcc acc aag gat acc tat gac gca ctg cac atg cag gcc       1296
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala           
            420                 425                 430                   

ctg cct cca aga taa                                                   1311
Leu Pro Pro Arg                                                           
        435                                                               


<210>  97
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  97

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Glu Gly Arg Asp Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  98
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD16A_V158_K128E_K131E 8BBz


<220>
<221>  CDS
<222>  (1)..(1311)

<400>  98
atg gct ctg cct gtt aca gct ctg ctg ctg cct ctg gct ctg ctt ctg         48
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu           
1               5                   10                  15                

cat gct gcc aga cct ggc atg aga acc gag gat ctg cct aag gcc gtg         96
His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val           
            20                  25                  30                    

gtg ttc ctg gaa cct cag tgg tac aga gtg ctg gaa aag gac agc gtg        144
Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val           
        35                  40                  45                        

acc ctg aag tgc cag ggc gcc tat tct ccc gag gac aat agc acc cag        192
Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln           
    50                  55                  60                            

tgg ttc cac aac gag agc ctg atc agc agc cag gcc agc agc tac ttt        240
Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe           
65                  70                  75                  80            

atc gat gcc gcc acc gtg gac gac agc ggc gag tac aga tgc cag acc        288
Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr           
                85                  90                  95                

aat ctg agc acc ctg agc gac cct gtg cag ctg gaa gtg cac att gga        336
Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly           
            100                 105                 110                   

tgg ctg ctg ctt cag gcc cct aga tgg gtg ttc aaa gaa gag gac ccc        384
Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro           
        115                 120                 125                       

atc cac ctg aga tgc cac tct tgg aag aac aca gcc ctg cac aaa gtg        432
Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val           
    130                 135                 140                           

acc tac ctg cag aac ggc gag ggc aga gag tac ttc cac cac aac agc        480
Thr Tyr Leu Gln Asn Gly Glu Gly Arg Glu Tyr Phe His His Asn Ser           
145                 150                 155                 160           

gac ttc tac atc ccc aag gcc aca ctg aag gac tcc ggc tcc tac ttc        528
Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe           
                165                 170                 175               

tgt aga ggc ctc gtg ggc agc aag aac gtg tcc agc gag aca gtg aac        576
Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn           
            180                 185                 190                   

atc acc atc aca cag ggc ctc gcc gtg tct acc atc agc agc ttt ttc        624
Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe           
        195                 200                 205                       

cca cct ggc tac cag acc acc aca cca gct cct aga cct cca act cct        672
Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro           
    210                 215                 220                           

gct cca aca atc gcc agc cag cct ctg tct ctg agg cca gaa gct tgt        720
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys           
225                 230                 235                 240           

aga cct gct gct ggc gga gcc gtg cat aca aga gga ctg gat ttc gcc        768
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala           
                245                 250                 255               

tgc gat atc tac atc tgg gcc cct ctg gct ggc aca tgt ggc gtt ctg        816
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu           
            260                 265                 270                   

ctg ctc agc ctg gtc atc acc ctg tac tgc aag cgg ggc aga aag aaa        864
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys           
        275                 280                 285                       

ctg ctg tac atc ttc aag cag ccc ttc atg cgg ccc gtg cag acc aca        912
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr           
    290                 295                 300                           

caa gag gaa gat ggc tgc agc tgt cgg ttc ccc gag gaa gaa gaa ggc        960
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly           
305                 310                 315                 320           

ggc tgc gag ctg aga gtg aag ttc agc aga tcc gcc gac gct cct gcc       1008
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala           
                325                 330                 335               

tat cag cag gga cag aac cag ctg tac aac gag ctg aac ctg ggg aga       1056
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg           
            340                 345                 350                   

aga gaa gag tac gac gtg ctg gac aag cgg aga ggc aga gat cct gag       1104
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu           
        355                 360                 365                       

atg ggc ggc aag ccc aga cgg aag aat cct caa gag ggc ctg tat aat       1152
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn           
    370                 375                 380                           

gag ctg cag aaa gac aag atg gcc gag gcc tac agc gag atc gga atg       1200
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met           
385                 390                 395                 400           

aag ggc gag cgc aga aga ggc aag gga cac gat gga ctg tac cag ggc       1248
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly           
                405                 410                 415               

ctg agc acc gcc acc aag gat acc tat gac gca ctg cac atg cag gcc       1296
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala           
            420                 425                 430                   

ctg cct cca aga taa                                                   1311
Leu Pro Pro Arg                                                           
        435                                                               


<210>  99
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  99

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Glu Gly Arg Glu Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  100
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD16A_V158_K131D_N38Q 8BBz


<220>
<221>  CDS
<222>  (1)..(1311)

<400>  100
atg gct ctg cct gtt aca gct ctg ctg ctg cct ctg gct ctg ctt ctg         48
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu           
1               5                   10                  15                

cat gct gcc aga cct ggc atg aga acc gag gat ctg cct aag gcc gtg         96
His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val           
            20                  25                  30                    

gtg ttc ctg gaa cct cag tgg tac aga gtg ctg gaa aag gac agc gtg        144
Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val           
        35                  40                  45                        

acc ctg aag tgc cag ggc gcc tat tct ccc gag gac cag agc acc cag        192
Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Gln Ser Thr Gln           
    50                  55                  60                            

tgg ttc cac aac gag agc ctg atc agc agc cag gcc agc agc tac ttt        240
Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe           
65                  70                  75                  80            

atc gat gcc gcc acc gtg gac gac agc ggc gag tac aga tgc cag acc        288
Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr           
                85                  90                  95                

aat ctg agc acc ctg agc gac cct gtg cag ctg gaa gtg cac att gga        336
Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly           
            100                 105                 110                   

tgg ctg ctg ctt cag gcc cct aga tgg gtg ttc aaa gaa gag gac ccc        384
Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro           
        115                 120                 125                       

atc cac ctg aga tgc cac tct tgg aag aac aca gcc ctg cac aaa gtg        432
Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val           
    130                 135                 140                           

acc tac ctg cag aac ggc aag ggc aga gac tac ttc cac cac aac agc        480
Thr Tyr Leu Gln Asn Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser           
145                 150                 155                 160           

gac ttc tac atc ccc aag gcc aca ctg aag gac tcc ggc tcc tac ttc        528
Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe           
                165                 170                 175               

tgt aga ggc ctc gtg ggc agc aag aac gtg tcc agc gag aca gtg aac        576
Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn           
            180                 185                 190                   

atc acc atc aca cag ggc ctc gcc gtg tct acc atc agc agc ttt ttc        624
Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe           
        195                 200                 205                       

cca cct ggc tac cag acc acc aca cca gct cct aga cct cca act cct        672
Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro           
    210                 215                 220                           

gct cca aca atc gcc agc cag cct ctg tct ctg agg cca gaa gct tgt        720
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys           
225                 230                 235                 240           

aga cct gct gct ggc gga gcc gtg cat aca aga gga ctg gat ttc gcc        768
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala           
                245                 250                 255               

tgc gat atc tac atc tgg gcc cct ctg gct ggc aca tgt ggc gtt ctg        816
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu           
            260                 265                 270                   

ctg ctc agc ctg gtc atc acc ctg tac tgc aag cgg ggc aga aag aaa        864
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys           
        275                 280                 285                       

ctg ctg tac atc ttc aag cag ccc ttc atg cgg ccc gtg cag acc aca        912
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr           
    290                 295                 300                           

caa gag gaa gat ggc tgc agc tgt cgg ttc ccc gag gaa gaa gaa ggc        960
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly           
305                 310                 315                 320           

ggc tgc gag ctg aga gtg aag ttc agc aga tcc gcc gac gct cct gcc       1008
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala           
                325                 330                 335               

tat cag cag gga cag aac cag ctg tac aac gag ctg aac ctg ggg aga       1056
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg           
            340                 345                 350                   

aga gaa gag tac gac gtg ctg gac aag cgg aga ggc aga gat cct gag       1104
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu           
        355                 360                 365                       

atg ggc ggc aag ccc aga cgg aag aat cct caa gag ggc ctg tat aat       1152
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn           
    370                 375                 380                           

gag ctg cag aaa gac aag atg gcc gag gcc tac agc gag atc gga atg       1200
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met           
385                 390                 395                 400           

aag ggc gag cgc aga aga ggc aag gga cac gat gga ctg tac cag ggc       1248
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly           
                405                 410                 415               

ctg agc acc gcc acc aag gat acc tat gac gca ctg cac atg cag gcc       1296
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala           
            420                 425                 430                   

ctg cct cca aga taa                                                   1311
Leu Pro Pro Arg                                                           
        435                                                               


<210>  101
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  101

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Gln Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  102
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD16A_V158_K131D_N74Q 8BBz


<220>
<221>  CDS
<222>  (1)..(1311)

<400>  102
atg gct ctg cct gtt aca gct ctg ctg ctg cct ctg gct ctg ctt ctg         48
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu           
1               5                   10                  15                

cat gct gcc aga cct ggc atg aga acc gag gat ctg cct aag gcc gtg         96
His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val           
            20                  25                  30                    

gtg ttc ctg gaa cct cag tgg tac aga gtg ctg gaa aag gac agc gtg        144
Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val           
        35                  40                  45                        

acc ctg aag tgc cag ggc gcc tat tct ccc gag gac aat agc acc cag        192
Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln           
    50                  55                  60                            

tgg ttc cac aac gag agc ctg atc agc agc cag gcc agc agc tac ttt        240
Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe           
65                  70                  75                  80            

atc gat gcc gcc acc gtg gac gac agc ggc gag tac aga tgt caa acc        288
Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr           
                85                  90                  95                

cag ctg agc acc ctg agc gac cct gtg cag ctg gaa gtg cac att gga        336
Gln Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly           
            100                 105                 110                   

tgg ctg ctg ctt cag gcc cct aga tgg gtg ttc aaa gaa gag gac ccc        384
Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro           
        115                 120                 125                       

atc cac ctg aga tgc cac tct tgg aag aac aca gcc ctg cac aaa gtg        432
Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val           
    130                 135                 140                           

acc tac ctg cag aac ggc aag ggc aga gac tac ttc cac cac aac agc        480
Thr Tyr Leu Gln Asn Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser           
145                 150                 155                 160           

gac ttc tac atc ccc aag gcc aca ctg aag gac tcc ggc tcc tac ttc        528
Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe           
                165                 170                 175               

tgt aga ggc ctc gtg ggc agc aag aac gtg tcc agc gag aca gtg aac        576
Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn           
            180                 185                 190                   

atc acc atc aca cag ggc ctc gcc gtg tct acc atc agc agc ttt ttc        624
Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe           
        195                 200                 205                       

cca cct ggc tac cag acc acc aca cca gct cct aga cct cca act cct        672
Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro           
    210                 215                 220                           

gct cca aca atc gcc agc cag cct ctg tct ctg agg cca gaa gct tgt        720
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys           
225                 230                 235                 240           

aga cct gct gct ggc gga gcc gtg cat aca aga gga ctg gat ttc gcc        768
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala           
                245                 250                 255               

tgc gat atc tac atc tgg gcc cct ctg gct ggc aca tgt ggc gtt ctg        816
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu           
            260                 265                 270                   

ctg ctc agc ctg gtc atc acc ctg tac tgc aag cgg ggc aga aag aaa        864
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys           
        275                 280                 285                       

ctg ctg tac atc ttc aag cag ccc ttc atg cgg ccc gtg cag acc aca        912
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr           
    290                 295                 300                           

caa gag gaa gat ggc tgc agc tgt cgg ttc ccc gag gaa gaa gaa ggc        960
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly           
305                 310                 315                 320           

ggc tgc gag ctg aga gtg aag ttc agc aga tcc gcc gac gct cct gcc       1008
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala           
                325                 330                 335               

tat cag cag gga cag aac cag ctg tac aac gag ctg aac ctg ggg aga       1056
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg           
            340                 345                 350                   

aga gaa gag tac gac gtg ctg gac aag cgg aga ggc aga gat cct gag       1104
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu           
        355                 360                 365                       

atg ggc ggc aag ccc aga cgg aag aat cct caa gag ggc ctg tat aat       1152
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn           
    370                 375                 380                           

gag ctg cag aaa gac aag atg gcc gag gcc tac agc gag atc gga atg       1200
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met           
385                 390                 395                 400           

aag ggc gag cgc aga aga ggc aag gga cac gat gga ctg tac cag ggc       1248
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly           
                405                 410                 415               

ctg agc acc gcc acc aag gat acc tat gac gca ctg cac atg cag gcc       1296
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala           
            420                 425                 430                   

ctg cct cca aga taa                                                   1311
Leu Pro Pro Arg                                                           
        435                                                               


<210>  103
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  103

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val 
            20                  25                  30          


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
        35                  40                  45              


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
    50                  55                  60                  


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
                85                  90                  95      


Gln Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
            100                 105                 110         


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
        115                 120                 125             


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
    130                 135                 140                 


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Asp Tyr Phe His His Asn Ser 
145                 150                 155                 160 


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
                165                 170                 175     


Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
            180                 185                 190         


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
        195                 200                 205             


Pro Pro Gly Tyr Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    210                 215                 220                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
225                 230                 235                 240 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                245                 250                 255     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  104
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  104

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


