                         SEQUENCE LISTING

<110>  QUEEN MARY UNIVERSITY OF LONDON
 
<120>  AGRIN POLYPEPTIDE AND USES THEREOF

<130>  N419727WO

<150>  GB 2012804.7
<151>  2020-08-17

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  2045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild type human agrin define by GenBank Accession No. BAD52440.1

<400>  1

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Val Pro His Thr  Val Leu Asn 
    1745                 1750                 1755             


Leu Lys  Glu Pro Leu Tyr Val  Gly Gly Ala Pro Asp  Phe Ser Lys 
    1760                 1765                 1770             


Leu Ala  Arg Ala Ala Ala Val  Ser Ser Gly Phe Asp  Gly Ala Ile 
    1775                 1780                 1785             


Gln Leu  Val Ser Leu Gly Gly  Arg Gln Leu Leu Thr  Pro Glu His 
    1790                 1795                 1800             


Val Leu  Arg Gln Val Asp Val  Thr Ser Phe Ala Gly  His Pro Cys 
    1805                 1810                 1815             


Thr Arg  Ala Ser Gly His Pro  Cys Leu Asn Gly Ala  Ser Cys Val 
    1820                 1825                 1830             


Pro Arg  Glu Ala Ala Tyr Val  Cys Leu Cys Pro Gly  Gly Phe Ser 
    1835                 1840                 1845             


Gly Pro  His Cys Glu Lys Gly  Leu Val Glu Lys Ser  Ala Gly Asp 
    1850                 1855                 1860             


Val Asp  Thr Leu Ala Phe Asp  Gly Arg Thr Phe Val  Glu Tyr Leu 
    1865                 1870                 1875             


Asn Ala  Val Thr Glu Ser Glu  Lys Ala Leu Gln Ser  Asn His Phe 
    1880                 1885                 1890             


Glu Leu  Ser Leu Arg Thr Glu  Ala Thr Gln Gly Leu  Val Leu Trp 
    1895                 1900                 1905             


Ser Gly  Lys Ala Thr Glu Arg  Ala Asp Tyr Val Ala  Leu Ala Ile 
    1910                 1915                 1920             


Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn Leu Gly  Ser Gln Pro 
    1925                 1930                 1935             


Val Val  Leu Arg Ser Thr Val  Pro Val Asn Thr Asn  Arg Trp Leu 
    1940                 1945                 1950             


Arg Val  Val Ala His Arg Glu  Gln Arg Glu Gly Ser  Leu Gln Val 
    1955                 1960                 1965             


Gly Asn  Glu Ala Pro Val Thr  Gly Ser Ser Pro Leu  Gly Ala Thr 
    1970                 1975                 1980             


Gln Leu  Asp Thr Asp Gly Ala  Leu Trp Leu Gly Gly  Leu Pro Glu 
    1985                 1990                 1995             


Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala Tyr Gly  Thr Gly Phe 
    2000                 2005                 2010             


Val Gly  Cys Leu Arg Asp Val  Val Val Gly Arg His  Pro Leu His 
    2015                 2020                 2025             


Leu Leu  Glu Asp Ala Val Thr  Lys Pro Glu Leu Arg  Pro Cys Pro 
    2030                 2035                 2040             


Thr Pro  
    2045 


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 1244-1259 of wild type human agrin

<400>  2

His Val Arg Phe Met Asp Phe Asp Trp Phe Pro Ala Phe Ile Thr Gly 
1               5                   10                  15      


<210>  3
<211>  802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 1244-2045 of wild type human agrin

<400>  3

His Val Arg Phe Met Asp Phe Asp Trp Phe Pro Ala Phe Ile Thr Gly 
1               5                   10                  15      


Ala Thr Ser Gly Ala Ile Ala Ala Gly Ala Thr Ala Arg Ala Thr Thr 
            20                  25                  30          


Ala Ser Arg Leu Pro Ser Ser Ala Val Thr Pro Arg Ala Pro His Pro 
        35                  40                  45              


Ser His Thr Ser Gln Pro Val Ala Lys Thr Thr Ala Ala Pro Thr Thr 
    50                  55                  60                  


Arg Arg Pro Pro Thr Thr Ala Pro Ser Arg Val Pro Gly Arg Arg Pro 
65                  70                  75                  80  


Pro Ala Pro Gln Gln Pro Pro Lys Pro Cys Asp Ser Gln Pro Cys Phe 
                85                  90                  95      


His Gly Gly Thr Cys Gln Asp Trp Ala Leu Gly Gly Gly Phe Thr Cys 
            100                 105                 110         


Ser Cys Pro Ala Gly Arg Gly Gly Ala Val Cys Glu Lys Val Leu Gly 
        115                 120                 125             


Ala Pro Val Pro Ala Phe Glu Gly Arg Ser Phe Leu Ala Phe Pro Thr 
    130                 135                 140                 


Leu Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu 
145                 150                 155                 160 


Glu Pro Gln Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp 
                165                 170                 175     


Phe Leu Ala Leu Ala Leu Leu Asp Gly Arg Val Gln Leu Arg Phe Asp 
            180                 185                 190         


Thr Gly Ser Gly Pro Ala Val Leu Thr Ser Ala Val Pro Val Glu Pro 
        195                 200                 205             


Gly Gln Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Arg Gly Thr 
    210                 215                 220                 


Leu Ser Val Asp Gly Glu Thr Pro Val Leu Gly Glu Ser Pro Ser Gly 
225                 230                 235                 240 


Thr Asp Gly Leu Asn Leu Asp Thr Asp Leu Phe Val Gly Gly Val Pro 
                245                 250                 255     


Glu Asp Gln Ala Ala Val Ala Leu Glu Arg Thr Phe Val Gly Ala Gly 
            260                 265                 270         


Leu Arg Gly Cys Ile Arg Leu Leu Asp Val Asn Asn Gln Arg Leu Glu 
        275                 280                 285             


Leu Gly Ile Gly Pro Gly Ala Ala Thr Arg Gly Ser Gly Val Gly Glu 
    290                 295                 300                 


Cys Gly Asp His Pro Cys Leu Pro Asn Pro Cys His Gly Gly Ala Pro 
305                 310                 315                 320 


Cys Gln Asn Leu Glu Ala Gly Arg Phe His Cys Gln Cys Pro Pro Gly 
                325                 330                 335     


Arg Val Gly Pro Thr Cys Ala Asp Glu Lys Ser Pro Cys Gln Pro Asn 
            340                 345                 350         


Pro Cys His Gly Ala Ala Pro Cys Arg Val Leu Pro Glu Gly Gly Ala 
        355                 360                 365             


Gln Cys Glu Cys Pro Leu Gly Arg Glu Gly Thr Phe Cys Gln Thr Ala 
    370                 375                 380                 


Ser Gly Gln Asp Gly Ser Gly Pro Phe Leu Ala Asp Phe Asn Gly Phe 
385                 390                 395                 400 


Ser His Leu Glu Leu Arg Gly Leu His Thr Phe Ala Arg Asp Leu Gly 
                405                 410                 415     


Glu Lys Met Ala Leu Glu Val Val Phe Leu Ala Arg Gly Pro Ser Gly 
            420                 425                 430         


Leu Leu Leu Tyr Asn Gly Gln Lys Thr Asp Gly Lys Gly Asp Phe Val 
        435                 440                 445             


Ser Leu Ala Leu Arg Asp Arg Arg Leu Glu Phe Arg Tyr Asp Leu Gly 
    450                 455                 460                 


Lys Gly Ala Ala Val Ile Arg Ser Arg Glu Pro Val Thr Leu Gly Ala 
465                 470                 475                 480 


Trp Thr Arg Val Ser Leu Glu Arg Asn Gly Arg Lys Gly Ala Leu Arg 
                485                 490                 495     


Val Gly Asp Gly Pro Arg Val Leu Gly Glu Ser Pro Val Pro His Thr 
            500                 505                 510         


Val Leu Asn Leu Lys Glu Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe 
        515                 520                 525             


Ser Lys Leu Ala Arg Ala Ala Ala Val Ser Ser Gly Phe Asp Gly Ala 
    530                 535                 540                 


Ile Gln Leu Val Ser Leu Gly Gly Arg Gln Leu Leu Thr Pro Glu His 
545                 550                 555                 560 


Val Leu Arg Gln Val Asp Val Thr Ser Phe Ala Gly His Pro Cys Thr 
                565                 570                 575     


Arg Ala Ser Gly His Pro Cys Leu Asn Gly Ala Ser Cys Val Pro Arg 
            580                 585                 590         


Glu Ala Ala Tyr Val Cys Leu Cys Pro Gly Gly Phe Ser Gly Pro His 
        595                 600                 605             


Cys Glu Lys Gly Leu Val Glu Lys Ser Ala Gly Asp Val Asp Thr Leu 
    610                 615                 620                 


Ala Phe Asp Gly Arg Thr Phe Val Glu Tyr Leu Asn Ala Val Thr Glu 
625                 630                 635                 640 


Ser Glu Lys Ala Leu Gln Ser Asn His Phe Glu Leu Ser Leu Arg Thr 
                645                 650                 655     


Glu Ala Thr Gln Gly Leu Val Leu Trp Ser Gly Lys Ala Thr Glu Arg 
            660                 665                 670         


Ala Asp Tyr Val Ala Leu Ala Ile Val Asp Gly His Leu Gln Leu Ser 
        675                 680                 685             


Tyr Asn Leu Gly Ser Gln Pro Val Val Leu Arg Ser Thr Val Pro Val 
    690                 695                 700                 


Asn Thr Asn Arg Trp Leu Arg Val Val Ala His Arg Glu Gln Arg Glu 
705                 710                 715                 720 


Gly Ser Leu Gln Val Gly Asn Glu Ala Pro Val Thr Gly Ser Ser Pro 
                725                 730                 735     


Leu Gly Ala Thr Gln Leu Asp Thr Asp Gly Ala Leu Trp Leu Gly Gly 
            740                 745                 750         


Leu Pro Glu Leu Pro Val Gly Pro Ala Leu Pro Lys Ala Tyr Gly Thr 
        755                 760                 765             


Gly Phe Val Gly Cys Leu Arg Asp Val Val Val Gly Arg His Pro Leu 
    770                 775                 780                 


His Leu Leu Glu Asp Ala Val Thr Lys Pro Glu Leu Arg Pro Cys Pro 
785                 790                 795                 800 


Thr Pro 
        


<210>  4
<211>  2068
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence corresponding to splice variant of human 
       agrin corresponding to UniProt accession no. O00468-1

<400>  4

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Lys Ser Arg Lys  Val Pro His 
    1745                 1750                 1755             


Thr Val  Leu Asn Leu Lys Glu  Pro Leu Tyr Val Gly  Gly Ala Pro 
    1760                 1765                 1770             


Asp Phe  Ser Lys Leu Ala Arg  Ala Ala Ala Val Ser  Ser Gly Phe 
    1775                 1780                 1785             


Asp Gly  Ala Ile Gln Leu Val  Ser Leu Gly Gly Arg  Gln Leu Leu 
    1790                 1795                 1800             


Thr Pro  Glu His Val Leu Arg  Gln Val Asp Val Thr  Ser Phe Ala 
    1805                 1810                 1815             


Gly His  Pro Cys Thr Arg Ala  Ser Gly His Pro Cys  Leu Asn Gly 
    1820                 1825                 1830             


Ala Ser  Cys Val Pro Arg Glu  Ala Ala Tyr Val Cys  Leu Cys Pro 
    1835                 1840                 1845             


Gly Gly  Phe Ser Gly Pro His  Cys Glu Lys Gly Leu  Val Glu Lys 
    1850                 1855                 1860             


Ser Ala  Gly Asp Val Asp Thr  Leu Ala Phe Asp Gly  Arg Thr Phe 
    1865                 1870                 1875             


Val Glu  Tyr Leu Asn Ala Val  Thr Glu Ser Glu Leu  Ala Asn Glu 
    1880                 1885                 1890             


Ile Pro  Val Pro Glu Thr Leu  Asp Ser Gly Ala Leu  His Ser Glu 
    1895                 1900                 1905             


Lys Ala  Leu Gln Ser Asn His  Phe Glu Leu Ser Leu  Arg Thr Glu 
    1910                 1915                 1920             


Ala Thr  Gln Gly Leu Val Leu  Trp Ser Gly Lys Ala  Thr Glu Arg 
    1925                 1930                 1935             


Ala Asp  Tyr Val Ala Leu Ala  Ile Val Asp Gly His  Leu Gln Leu 
    1940                 1945                 1950             


Ser Tyr  Asn Leu Gly Ser Gln  Pro Val Val Leu Arg  Ser Thr Val 
    1955                 1960                 1965             


Pro Val  Asn Thr Asn Arg Trp  Leu Arg Val Val Ala  His Arg Glu 
    1970                 1975                 1980             


Gln Arg  Glu Gly Ser Leu Gln  Val Gly Asn Glu Ala  Pro Val Thr 
    1985                 1990                 1995             


Gly Ser  Ser Pro Leu Gly Ala  Thr Gln Leu Asp Thr  Asp Gly Ala 
    2000                 2005                 2010             


Leu Trp  Leu Gly Gly Leu Pro  Glu Leu Pro Val Gly  Pro Ala Leu 
    2015                 2020                 2025             


Pro Lys  Ala Tyr Gly Thr Gly  Phe Val Gly Cys Leu  Arg Asp Val 
    2030                 2035                 2040             


Val Val  Gly Arg His Pro Leu  His Leu Leu Glu Asp  Ala Val Thr 
    2045                 2050                 2055             


Lys Pro  Glu Leu Arg Pro Cys  Pro Thr Pro 
    2060                 2065             


<210>  5
<211>  1964
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence corresponding to splice variant of human 
       agrin corresponding to UniProt accession no. O00468-2


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Met Pro Xaa Leu Ala Val Ala Arg Asp Thr Arg Gln Pro Ala Gly Ala 
1               5                   10                  15      


Ser Leu Leu Val Arg Gly Phe Met Val Pro Cys Asn Ala Cys Leu Ile 
            20                  25                  30          


Leu Leu Ala Thr Ala Thr Leu Gly Phe Ala Val Leu Leu Phe Leu Asn 
        35                  40                  45              


Asn Tyr Asp Lys Pro Gly Thr His Phe Thr Pro Val Pro Pro Thr Pro 
    50                  55                  60                  


Pro Asp Ala Cys Arg Gly Met Leu Cys Gly Phe Gly Ala Val Cys Glu 
65                  70                  75                  80  


Pro Asn Ala Glu Gly Pro Gly Arg Ala Ser Cys Val Cys Lys Lys Ser 
                85                  90                  95      


Pro Cys Pro Ser Val Val Ala Pro Val Cys Gly Ser Asp Ala Ser Thr 
            100                 105                 110         


Tyr Ser Asn Glu Cys Glu Leu Gln Arg Ala Gln Cys Ser Gln Gln Arg 
        115                 120                 125             


Arg Ile Arg Leu Leu Ser Arg Gly Pro Cys Gly Ser Arg Asp Pro Cys 
    130                 135                 140                 


Ser Asn Val Thr Cys Ser Phe Gly Ser Thr Cys Ala Arg Ser Ala Asp 
145                 150                 155                 160 


Gly Leu Thr Ala Ser Cys Leu Cys Pro Ala Thr Cys Arg Gly Ala Pro 
                165                 170                 175     


Glu Gly Thr Val Cys Gly Ser Asp Gly Ala Asp Tyr Pro Gly Glu Cys 
            180                 185                 190         


Gln Leu Leu Arg Arg Ala Cys Ala Arg Gln Glu Asn Val Phe Lys Lys 
        195                 200                 205             


Phe Asp Gly Pro Cys Asp Pro Cys Gln Gly Ala Leu Pro Asp Pro Ser 
    210                 215                 220                 


Arg Ser Cys Arg Val Asn Pro Arg Thr Arg Arg Pro Glu Met Leu Leu 
225                 230                 235                 240 


Arg Pro Glu Ser Cys Pro Ala Arg Gln Ala Pro Val Cys Gly Asp Asp 
                245                 250                 255     


Gly Val Thr Tyr Glu Asn Asp Cys Val Met Gly Arg Ser Gly Ala Ala 
            260                 265                 270         


Arg Gly Leu Leu Leu Gln Lys Val Arg Ser Gly Gln Cys Gln Gly Arg 
        275                 280                 285             


Asp Gln Cys Pro Glu Pro Cys Arg Phe Asn Ala Val Cys Leu Ser Arg 
    290                 295                 300                 


Arg Gly Arg Pro Arg Cys Ser Cys Asp Arg Val Thr Cys Asp Gly Ala 
305                 310                 315                 320 


Tyr Arg Pro Val Cys Ala Gln Asp Gly Arg Thr Tyr Asp Ser Asp Cys 
                325                 330                 335     


Trp Arg Gln Gln Ala Glu Cys Arg Gln Gln Arg Ala Ile Pro Ser Lys 
            340                 345                 350         


His Gln Gly Pro Cys Asp Gln Ala Pro Ser Pro Cys Leu Gly Val Gln 
        355                 360                 365             


Cys Ala Phe Gly Ala Thr Cys Ala Val Lys Asn Gly Gln Ala Ala Cys 
    370                 375                 380                 


Glu Cys Leu Gln Ala Cys Ser Ser Leu Tyr Asp Pro Val Cys Gly Ser 
385                 390                 395                 400 


Asp Gly Val Thr Tyr Gly Ser Ala Cys Glu Leu Glu Ala Thr Ala Cys 
                405                 410                 415     


Thr Leu Gly Arg Glu Ile Gln Val Ala Arg Lys Gly Pro Cys Asp Arg 
            420                 425                 430         


Cys Gly Gln Cys Arg Phe Gly Ala Leu Cys Glu Ala Glu Thr Gly Arg 
        435                 440                 445             


Cys Val Cys Pro Ser Glu Cys Val Ala Leu Ala Gln Pro Val Cys Gly 
    450                 455                 460                 


Ser Asp Gly His Thr Tyr Pro Ser Glu Cys Met Leu His Val His Ala 
465                 470                 475                 480 


Cys Thr His Gln Ile Ser Leu His Val Ala Ser Ala Gly Pro Cys Glu 
                485                 490                 495     


Thr Cys Gly Asp Ala Val Cys Ala Phe Gly Ala Val Cys Ser Ala Gly 
            500                 505                 510         


Gln Cys Val Cys Pro Arg Cys Glu His Pro Pro Pro Gly Pro Val Cys 
        515                 520                 525             


Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala Cys Glu Leu Arg Glu Ala 
    530                 535                 540                 


Ala Cys Leu Gln Gln Thr Gln Ile Glu Glu Ala Arg Ala Gly Pro Cys 
545                 550                 555                 560 


Glu Gln Ala Glu Cys Gly Ser Gly Gly Ser Gly Ser Gly Glu Asp Gly 
                565                 570                 575     


Asp Cys Glu Gln Glu Leu Cys Arg Gln Arg Gly Gly Ile Trp Asp Glu 
            580                 585                 590         


Asp Ser Glu Asp Gly Pro Cys Val Cys Asp Phe Ser Cys Gln Ser Val 
        595                 600                 605             


Pro Gly Ser Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Ser Thr Glu 
    610                 615                 620                 


Cys Glu Leu Lys Lys Ala Arg Cys Glu Ser Gln Arg Gly Leu Tyr Val 
625                 630                 635                 640 


Ala Ala Gln Gly Ala Cys Arg Gly Pro Thr Phe Ala Pro Leu Pro Pro 
                645                 650                 655     


Val Ala Pro Leu His Cys Ala Gln Thr Pro Tyr Gly Cys Cys Gln Asp 
            660                 665                 670         


Asn Ile Thr Ala Ala Arg Gly Val Gly Leu Ala Gly Cys Pro Ser Ala 
        675                 680                 685             


Cys Gln Cys Asn Pro His Gly Ser Tyr Gly Gly Thr Cys Asp Pro Ala 
    690                 695                 700                 


Thr Gly Gln Cys Ser Cys Arg Pro Gly Val Gly Gly Leu Arg Cys Asp 
705                 710                 715                 720 


Arg Cys Glu Pro Gly Phe Trp Asn Phe Arg Gly Ile Val Thr Asp Gly 
                725                 730                 735     


Arg Ser Gly Cys Thr Pro Cys Ser Cys Asp Pro Gln Gly Ala Val Arg 
            740                 745                 750         


Asp Asp Cys Glu Gln Met Thr Gly Leu Cys Ser Cys Lys Pro Gly Val 
        755                 760                 765             


Ala Gly Pro Lys Cys Gly Gln Cys Pro Asp Gly Arg Ala Leu Gly Pro 
    770                 775                 780                 


Ala Gly Cys Glu Ala Asp Ala Ser Ala Pro Ala Thr Cys Ala Glu Met 
785                 790                 795                 800 


Arg Cys Glu Phe Gly Ala Arg Cys Val Glu Glu Ser Gly Ser Ala His 
                805                 810                 815     


Cys Val Cys Pro Met Leu Thr Cys Pro Glu Ala Asn Ala Thr Lys Val 
            820                 825                 830         


Cys Gly Ser Asp Gly Val Thr Tyr Gly Asn Glu Cys Gln Leu Lys Thr 
        835                 840                 845             


Ile Ala Cys Arg Gln Gly Leu Gln Ile Ser Ile Gln Ser Leu Gly Pro 
    850                 855                 860                 


Cys Gln Glu Ala Val Ala Pro Ser Thr His Pro Thr Ser Ala Ser Val 
865                 870                 875                 880 


Thr Val Thr Thr Pro Gly Leu Leu Leu Ser Gln Ala Leu Pro Ala Pro 
                885                 890                 895     


Pro Gly Ala Leu Pro Leu Ala Pro Ser Ser Thr Ala His Ser Gln Thr 
            900                 905                 910         


Thr Pro Pro Pro Ser Ser Arg Pro Arg Thr Thr Ala Ser Val Pro Arg 
        915                 920                 925             


Thr Thr Val Trp Pro Val Leu Thr Val Pro Pro Thr Ala Pro Ser Pro 
    930                 935                 940                 


Ala Pro Ser Leu Val Ala Ser Ala Phe Gly Glu Ser Gly Ser Thr Asp 
945                 950                 955                 960 


Gly Ser Ser Asp Glu Glu Leu Ser Gly Asp Gln Glu Ala Ser Gly Gly 
                965                 970                 975     


Gly Ser Gly Gly Leu Glu Pro Leu Glu Gly Ser Ser Val Ala Thr Pro 
            980                 985                 990         


Gly Pro Pro Val Glu Arg Ala Ser  Cys Tyr Asn Ser Ala  Leu Gly Cys 
        995                 1000                 1005             


Cys Ser  Asp Gly Lys Thr Pro  Ser Leu Asp Ala Glu  Gly Ser Asn 
    1010                 1015                 1020             


Cys Pro  Ala Thr Lys Val Phe  Gln Gly Val Leu Glu  Leu Glu Gly 
    1025                 1030                 1035             


Val Glu  Gly Gln Glu Leu Phe  Tyr Thr Pro Glu Met  Ala Asp Pro 
    1040                 1045                 1050             


Lys Ser  Glu Leu Phe Gly Glu  Thr Ala Arg Ser Ile  Glu Ser Thr 
    1055                 1060                 1065             


Leu Asp  Asp Leu Phe Arg Asn  Ser Asp Val Lys Lys  Asp Phe Arg 
    1070                 1075                 1080             


Ser Val  Arg Leu Arg Asp Leu  Gly Pro Gly Lys Ser  Val Arg Ala 
    1085                 1090                 1095             


Ile Val  Asp Val His Phe Asp  Pro Thr Thr Ala Phe  Arg Ala Pro 
    1100                 1105                 1110             


Asp Val  Ala Arg Ala Leu Leu  Arg Gln Ile Gln Val  Ser Arg Arg 
    1115                 1120                 1125             


Arg Ser  Leu Gly Val Arg Arg  Pro Leu Gln Glu His  Val Arg Phe 
    1130                 1135                 1140             


Met Asp  Phe Asp Trp Phe Pro  Ala Phe Ile Thr Gly  Ala Thr Ser 
    1145                 1150                 1155             


Gly Ala  Ile Ala Ala Gly Ala  Thr Ala Arg Ala Thr  Thr Ala Ser 
    1160                 1165                 1170             


Arg Leu  Pro Ser Ser Ala Val  Thr Pro Arg Ala Pro  His Pro Ser 
    1175                 1180                 1185             


His Thr  Ser Gln Pro Val Ala  Lys Thr Thr Ala Ala  Pro Thr Thr 
    1190                 1195                 1200             


Arg Arg  Pro Pro Thr Thr Ala  Pro Ser Arg Val Pro  Gly Arg Arg 
    1205                 1210                 1215             


Pro Pro  Ala Pro Gln Gln Pro  Pro Lys Pro Cys Asp  Ser Gln Pro 
    1220                 1225                 1230             


Cys Phe  His Gly Gly Thr Cys  Gln Asp Trp Ala Leu  Gly Gly Gly 
    1235                 1240                 1245             


Phe Thr  Cys Ser Cys Pro Ala  Gly Arg Gly Gly Ala  Val Cys Glu 
    1250                 1255                 1260             


Lys Val  Leu Gly Ala Pro Val  Pro Ala Phe Glu Gly  Arg Ser Phe 
    1265                 1270                 1275             


Leu Ala  Phe Pro Thr Leu Arg  Ala Tyr His Thr Leu  Arg Leu Ala 
    1280                 1285                 1290             


Leu Glu  Phe Arg Ala Leu Glu  Pro Gln Gly Leu Leu  Leu Tyr Asn 
    1295                 1300                 1305             


Gly Asn  Ala Arg Gly Lys Asp  Phe Leu Ala Leu Ala  Leu Leu Asp 
    1310                 1315                 1320             


Gly Arg  Val Gln Leu Arg Phe  Asp Thr Gly Ser Gly  Pro Ala Val 
    1325                 1330                 1335             


Leu Thr  Ser Ala Val Pro Val  Glu Pro Gly Gln Trp  His Arg Leu 
    1340                 1345                 1350             


Glu Leu  Ser Arg His Trp Arg  Arg Gly Thr Leu Ser  Val Asp Gly 
    1355                 1360                 1365             


Glu Thr  Pro Val Leu Gly Glu  Ser Pro Ser Gly Thr  Asp Gly Leu 
    1370                 1375                 1380             


Asn Leu  Asp Thr Asp Leu Phe  Val Gly Gly Val Pro  Glu Asp Gln 
    1385                 1390                 1395             


Ala Ala  Val Ala Leu Glu Arg  Thr Phe Val Gly Ala  Gly Leu Arg 
    1400                 1405                 1410             


Gly Cys  Ile Arg Leu Leu Asp  Val Asn Asn Gln Arg  Leu Glu Leu 
    1415                 1420                 1425             


Gly Ile  Gly Pro Gly Ala Ala  Thr Arg Gly Ser Gly  Val Gly Glu 
    1430                 1435                 1440             


Cys Gly  Asp His Pro Cys Leu  Pro Asn Pro Cys His  Gly Gly Ala 
    1445                 1450                 1455             


Pro Cys  Gln Asn Leu Glu Ala  Gly Arg Phe His Cys  Gln Cys Pro 
    1460                 1465                 1470             


Pro Gly  Arg Val Gly Pro Thr  Cys Ala Asp Glu Lys  Ser Pro Cys 
    1475                 1480                 1485             


Gln Pro  Asn Pro Cys His Gly  Ala Ala Pro Cys Arg  Val Leu Pro 
    1490                 1495                 1500             


Glu Gly  Gly Ala Gln Cys Glu  Cys Pro Leu Gly Arg  Glu Gly Thr 
    1505                 1510                 1515             


Phe Cys  Gln Thr Ala Ser Gly  Gln Asp Gly Ser Gly  Pro Phe Leu 
    1520                 1525                 1530             


Ala Asp  Phe Asn Gly Phe Ser  His Leu Glu Leu Arg  Gly Leu His 
    1535                 1540                 1545             


Thr Phe  Ala Arg Asp Leu Gly  Glu Lys Met Ala Leu  Glu Val Val 
    1550                 1555                 1560             


Phe Leu  Ala Arg Gly Pro Ser  Gly Leu Leu Leu Tyr  Asn Gly Gln 
    1565                 1570                 1575             


Lys Thr  Asp Gly Lys Gly Asp  Phe Val Ser Leu Ala  Leu Arg Asp 
    1580                 1585                 1590             


Arg Arg  Leu Glu Phe Arg Tyr  Asp Leu Gly Lys Gly  Ala Ala Val 
    1595                 1600                 1605             


Ile Arg  Ser Arg Glu Pro Val  Thr Leu Gly Ala Trp  Thr Arg Val 
    1610                 1615                 1620             


Ser Leu  Glu Arg Asn Gly Arg  Lys Gly Ala Leu Arg  Val Gly Asp 
    1625                 1630                 1635             


Gly Pro  Arg Val Leu Gly Glu  Ser Pro Lys Ser Arg  Lys Val Pro 
    1640                 1645                 1650             


His Thr  Val Leu Asn Leu Lys  Glu Pro Leu Tyr Val  Gly Gly Ala 
    1655                 1660                 1665             


Pro Asp  Phe Ser Lys Leu Ala  Arg Ala Ala Ala Val  Ser Ser Gly 
    1670                 1675                 1680             


Phe Asp  Gly Ala Ile Gln Leu  Val Ser Leu Gly Gly  Arg Gln Leu 
    1685                 1690                 1695             


Leu Thr  Pro Glu His Val Leu  Arg Gln Val Asp Val  Thr Ser Phe 
    1700                 1705                 1710             


Ala Gly  His Pro Cys Thr Arg  Ala Ser Gly His Pro  Cys Leu Asn 
    1715                 1720                 1725             


Gly Ala  Ser Cys Val Pro Arg  Glu Ala Ala Tyr Val  Cys Leu Cys 
    1730                 1735                 1740             


Pro Gly  Gly Phe Ser Gly Pro  His Cys Glu Lys Gly  Leu Val Glu 
    1745                 1750                 1755             


Lys Ser  Ala Gly Asp Val Asp  Thr Leu Ala Phe Asp  Gly Arg Thr 
    1760                 1765                 1770             


Phe Val  Glu Tyr Leu Asn Ala  Val Thr Glu Ser Glu  Leu Ala Asn 
    1775                 1780                 1785             


Glu Ile  Pro Val Pro Glu Thr  Leu Asp Ser Gly Ala  Leu His Ser 
    1790                 1795                 1800             


Glu Lys  Ala Leu Gln Ser Asn  His Phe Glu Leu Ser  Leu Arg Thr 
    1805                 1810                 1815             


Glu Ala  Thr Gln Gly Leu Val  Leu Trp Ser Gly Lys  Ala Thr Glu 
    1820                 1825                 1830             


Arg Ala  Asp Tyr Val Ala Leu  Ala Ile Val Asp Gly  His Leu Gln 
    1835                 1840                 1845             


Leu Ser  Tyr Asn Leu Gly Ser  Gln Pro Val Val Leu  Arg Ser Thr 
    1850                 1855                 1860             


Val Pro  Val Asn Thr Asn Arg  Trp Leu Arg Val Val  Ala His Arg 
    1865                 1870                 1875             


Glu Gln  Arg Glu Gly Ser Leu  Gln Val Gly Asn Glu  Ala Pro Val 
    1880                 1885                 1890             


Thr Gly  Ser Ser Pro Leu Gly  Ala Thr Gln Leu Asp  Thr Asp Gly 
    1895                 1900                 1905             


Ala Leu  Trp Leu Gly Gly Leu  Pro Glu Leu Pro Val  Gly Pro Ala 
    1910                 1915                 1920             


Leu Pro  Lys Ala Tyr Gly Thr  Gly Phe Val Gly Cys  Leu Arg Asp 
    1925                 1930                 1935             


Val Val  Val Gly Arg His Pro  Leu His Leu Leu Glu  Asp Ala Val 
    1940                 1945                 1950             


Thr Lys  Pro Glu Leu Arg Pro  Cys Pro Thr Pro 
    1955                 1960                 


<210>  6
<211>  2049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence corresponding to splice variant of human 
       agrin corresponding to UniProt accession no. O00468-3

<400>  6

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Lys Ser Arg Lys  Val Pro His 
    1745                 1750                 1755             


Thr Val  Leu Asn Leu Lys Glu  Pro Leu Tyr Val Gly  Gly Ala Pro 
    1760                 1765                 1770             


Asp Phe  Ser Lys Leu Ala Arg  Ala Ala Ala Val Ser  Ser Gly Phe 
    1775                 1780                 1785             


Asp Gly  Ala Ile Gln Leu Val  Ser Leu Gly Gly Arg  Gln Leu Leu 
    1790                 1795                 1800             


Thr Pro  Glu His Val Leu Arg  Gln Val Asp Val Thr  Ser Phe Ala 
    1805                 1810                 1815             


Gly His  Pro Cys Thr Arg Ala  Ser Gly His Pro Cys  Leu Asn Gly 
    1820                 1825                 1830             


Ala Ser  Cys Val Pro Arg Glu  Ala Ala Tyr Val Cys  Leu Cys Pro 
    1835                 1840                 1845             


Gly Gly  Phe Ser Gly Pro His  Cys Glu Lys Gly Leu  Val Glu Lys 
    1850                 1855                 1860             


Ser Ala  Gly Asp Val Asp Thr  Leu Ala Phe Asp Gly  Arg Thr Phe 
    1865                 1870                 1875             


Val Glu  Tyr Leu Asn Ala Val  Thr Glu Ser Glu Lys  Ala Leu Gln 
    1880                 1885                 1890             


Ser Asn  His Phe Glu Leu Ser  Leu Arg Thr Glu Ala  Thr Gln Gly 
    1895                 1900                 1905             


Leu Val  Leu Trp Ser Gly Lys  Ala Thr Glu Arg Ala  Asp Tyr Val 
    1910                 1915                 1920             


Ala Leu  Ala Ile Val Asp Gly  His Leu Gln Leu Ser  Tyr Asn Leu 
    1925                 1930                 1935             


Gly Ser  Gln Pro Val Val Leu  Arg Ser Thr Val Pro  Val Asn Thr 
    1940                 1945                 1950             


Asn Arg  Trp Leu Arg Val Val  Ala His Arg Glu Gln  Arg Glu Gly 
    1955                 1960                 1965             


Ser Leu  Gln Val Gly Asn Glu  Ala Pro Val Thr Gly  Ser Ser Pro 
    1970                 1975                 1980             


Leu Gly  Ala Thr Gln Leu Asp  Thr Asp Gly Ala Leu  Trp Leu Gly 
    1985                 1990                 1995             


Gly Leu  Pro Glu Leu Pro Val  Gly Pro Ala Leu Pro  Lys Ala Tyr 
    2000                 2005                 2010             


Gly Thr  Gly Phe Val Gly Cys  Leu Arg Asp Val Val  Val Gly Arg 
    2015                 2020                 2025             


His Pro  Leu His Leu Leu Glu  Asp Ala Val Thr Lys  Pro Glu Leu 
    2030                 2035                 2040             


Arg Pro  Cys Pro Thr Pro 
    2045                 


<210>  7
<211>  2060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence corresponding to splice variant of human 
       agrin corresponding to UniProt accession no. O00468-4

<400>  7

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Lys Ser Arg Lys  Val Pro His 
    1745                 1750                 1755             


Thr Val  Leu Asn Leu Lys Glu  Pro Leu Tyr Val Gly  Gly Ala Pro 
    1760                 1765                 1770             


Asp Phe  Ser Lys Leu Ala Arg  Ala Ala Ala Val Ser  Ser Gly Phe 
    1775                 1780                 1785             


Asp Gly  Ala Ile Gln Leu Val  Ser Leu Gly Gly Arg  Gln Leu Leu 
    1790                 1795                 1800             


Thr Pro  Glu His Val Leu Arg  Gln Val Asp Val Thr  Ser Phe Ala 
    1805                 1810                 1815             


Gly His  Pro Cys Thr Arg Ala  Ser Gly His Pro Cys  Leu Asn Gly 
    1820                 1825                 1830             


Ala Ser  Cys Val Pro Arg Glu  Ala Ala Tyr Val Cys  Leu Cys Pro 
    1835                 1840                 1845             


Gly Gly  Phe Ser Gly Pro His  Cys Glu Lys Gly Leu  Val Glu Lys 
    1850                 1855                 1860             


Ser Ala  Gly Asp Val Asp Thr  Leu Ala Phe Asp Gly  Arg Thr Phe 
    1865                 1870                 1875             


Val Glu  Tyr Leu Asn Ala Val  Thr Glu Ser Pro Glu  Thr Leu Asp 
    1880                 1885                 1890             


Ser Gly  Ala Leu His Ser Glu  Lys Ala Leu Gln Ser  Asn His Phe 
    1895                 1900                 1905             


Glu Leu  Ser Leu Arg Thr Glu  Ala Thr Gln Gly Leu  Val Leu Trp 
    1910                 1915                 1920             


Ser Gly  Lys Ala Thr Glu Arg  Ala Asp Tyr Val Ala  Leu Ala Ile 
    1925                 1930                 1935             


Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn Leu Gly  Ser Gln Pro 
    1940                 1945                 1950             


Val Val  Leu Arg Ser Thr Val  Pro Val Asn Thr Asn  Arg Trp Leu 
    1955                 1960                 1965             


Arg Val  Val Ala His Arg Glu  Gln Arg Glu Gly Ser  Leu Gln Val 
    1970                 1975                 1980             


Gly Asn  Glu Ala Pro Val Thr  Gly Ser Ser Pro Leu  Gly Ala Thr 
    1985                 1990                 1995             


Gln Leu  Asp Thr Asp Gly Ala  Leu Trp Leu Gly Gly  Leu Pro Glu 
    2000                 2005                 2010             


Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala Tyr Gly  Thr Gly Phe 
    2015                 2020                 2025             


Val Gly  Cys Leu Arg Asp Val  Val Val Gly Arg His  Pro Leu His 
    2030                 2035                 2040             


Leu Leu  Glu Asp Ala Val Thr  Lys Pro Glu Leu Arg  Pro Cys Pro 
    2045                 2050                 2055             


Thr Pro  
    2060 


<210>  8
<211>  2057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence corresponding to a splice variant of human 
       agrin corresponding to UniProt accession no. O00468-5

<400>  8

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Lys Ser Arg Lys  Val Pro His 
    1745                 1750                 1755             


Thr Val  Leu Asn Leu Lys Glu  Pro Leu Tyr Val Gly  Gly Ala Pro 
    1760                 1765                 1770             


Asp Phe  Ser Lys Leu Ala Arg  Ala Ala Ala Val Ser  Ser Gly Phe 
    1775                 1780                 1785             


Asp Gly  Ala Ile Gln Leu Val  Ser Leu Gly Gly Arg  Gln Leu Leu 
    1790                 1795                 1800             


Thr Pro  Glu His Val Leu Arg  Gln Val Asp Val Thr  Ser Phe Ala 
    1805                 1810                 1815             


Gly His  Pro Cys Thr Arg Ala  Ser Gly His Pro Cys  Leu Asn Gly 
    1820                 1825                 1830             


Ala Ser  Cys Val Pro Arg Glu  Ala Ala Tyr Val Cys  Leu Cys Pro 
    1835                 1840                 1845             


Gly Gly  Phe Ser Gly Pro His  Cys Glu Lys Gly Leu  Val Glu Lys 
    1850                 1855                 1860             


Ser Ala  Gly Asp Val Asp Thr  Leu Ala Phe Asp Gly  Arg Thr Phe 
    1865                 1870                 1875             


Val Glu  Tyr Leu Asn Ala Val  Thr Glu Ser Glu Leu  Ala Asn Glu 
    1880                 1885                 1890             


Ile Pro  Val Glu Lys Ala Leu  Gln Ser Asn His Phe  Glu Leu Ser 
    1895                 1900                 1905             


Leu Arg  Thr Glu Ala Thr Gln  Gly Leu Val Leu Trp  Ser Gly Lys 
    1910                 1915                 1920             


Ala Thr  Glu Arg Ala Asp Tyr  Val Ala Leu Ala Ile  Val Asp Gly 
    1925                 1930                 1935             


His Leu  Gln Leu Ser Tyr Asn  Leu Gly Ser Gln Pro  Val Val Leu 
    1940                 1945                 1950             


Arg Ser  Thr Val Pro Val Asn  Thr Asn Arg Trp Leu  Arg Val Val 
    1955                 1960                 1965             


Ala His  Arg Glu Gln Arg Glu  Gly Ser Leu Gln Val  Gly Asn Glu 
    1970                 1975                 1980             


Ala Pro  Val Thr Gly Ser Ser  Pro Leu Gly Ala Thr  Gln Leu Asp 
    1985                 1990                 1995             


Thr Asp  Gly Ala Leu Trp Leu  Gly Gly Leu Pro Glu  Leu Pro Val 
    2000                 2005                 2010             


Gly Pro  Ala Leu Pro Lys Ala  Tyr Gly Thr Gly Phe  Val Gly Cys 
    2015                 2020                 2025             


Leu Arg  Asp Val Val Val Gly  Arg His Pro Leu His  Leu Leu Glu 
    2030                 2035                 2040             


Asp Ala  Val Thr Lys Pro Glu  Leu Arg Pro Cys Pro  Thr Pro 
    2045                 2050                 2055         


<210>  9
<211>  2045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence corresponding to a splice variant of human 
       agrin corresponding to UniProt accession no. O00468-6

<400>  9

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Val Pro His Thr  Val Leu Asn 
    1745                 1750                 1755             


Leu Lys  Glu Pro Leu Tyr Val  Gly Gly Ala Pro Asp  Phe Ser Lys 
    1760                 1765                 1770             


Leu Ala  Arg Ala Ala Ala Val  Ser Ser Gly Phe Asp  Gly Ala Ile 
    1775                 1780                 1785             


Gln Leu  Val Ser Leu Gly Gly  Arg Gln Leu Leu Thr  Pro Glu His 
    1790                 1795                 1800             


Val Leu  Arg Gln Val Asp Val  Thr Ser Phe Ala Gly  His Pro Cys 
    1805                 1810                 1815             


Thr Arg  Ala Ser Gly His Pro  Cys Leu Asn Gly Ala  Ser Cys Val 
    1820                 1825                 1830             


Pro Arg  Glu Ala Ala Tyr Val  Cys Leu Cys Pro Gly  Gly Phe Ser 
    1835                 1840                 1845             


Gly Pro  His Cys Glu Lys Gly  Leu Val Glu Lys Ser  Ala Gly Asp 
    1850                 1855                 1860             


Val Asp  Thr Leu Ala Phe Asp  Gly Arg Thr Phe Val  Glu Tyr Leu 
    1865                 1870                 1875             


Asn Ala  Val Thr Glu Ser Glu  Lys Ala Leu Gln Ser  Asn His Phe 
    1880                 1885                 1890             


Glu Leu  Ser Leu Arg Thr Glu  Ala Thr Gln Gly Leu  Val Leu Trp 
    1895                 1900                 1905             


Ser Gly  Lys Ala Thr Glu Arg  Ala Asp Tyr Val Ala  Leu Ala Ile 
    1910                 1915                 1920             


Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn Leu Gly  Ser Gln Pro 
    1925                 1930                 1935             


Val Val  Leu Arg Ser Thr Val  Pro Val Asn Thr Asn  Arg Trp Leu 
    1940                 1945                 1950             


Arg Val  Val Ala His Arg Glu  Gln Arg Glu Gly Ser  Leu Gln Val 
    1955                 1960                 1965             


Gly Asn  Glu Ala Pro Val Thr  Gly Ser Ser Pro Leu  Gly Ala Thr 
    1970                 1975                 1980             


Gln Leu  Asp Thr Asp Gly Ala  Leu Trp Leu Gly Gly  Leu Pro Glu 
    1985                 1990                 1995             


Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala Tyr Gly  Thr Gly Phe 
    2000                 2005                 2010             


Val Gly  Cys Leu Arg Asp Val  Val Val Gly Arg His  Pro Leu His 
    2015                 2020                 2025             


Leu Leu  Glu Asp Ala Val Thr  Lys Pro Glu Leu Arg  Pro Cys Pro 
    2030                 2035                 2040             


Thr Pro  
    2045 


<210>  10
<211>  2064
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence corresponding to a splice variant of human 
       agrin corresponding to UniProt accession no. O00468-7

<400>  10

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Val Pro His Thr  Val Leu Asn 
    1745                 1750                 1755             


Leu Lys  Glu Pro Leu Tyr Val  Gly Gly Ala Pro Asp  Phe Ser Lys 
    1760                 1765                 1770             


Leu Ala  Arg Ala Ala Ala Val  Ser Ser Gly Phe Asp  Gly Ala Ile 
    1775                 1780                 1785             


Gln Leu  Val Ser Leu Gly Gly  Arg Gln Leu Leu Thr  Pro Glu His 
    1790                 1795                 1800             


Val Leu  Arg Gln Val Asp Val  Thr Ser Phe Ala Gly  His Pro Cys 
    1805                 1810                 1815             


Thr Arg  Ala Ser Gly His Pro  Cys Leu Asn Gly Ala  Ser Cys Val 
    1820                 1825                 1830             


Pro Arg  Glu Ala Ala Tyr Val  Cys Leu Cys Pro Gly  Gly Phe Ser 
    1835                 1840                 1845             


Gly Pro  His Cys Glu Lys Gly  Leu Val Glu Lys Ser  Ala Gly Asp 
    1850                 1855                 1860             


Val Asp  Thr Leu Ala Phe Asp  Gly Arg Thr Phe Val  Glu Tyr Leu 
    1865                 1870                 1875             


Asn Ala  Val Thr Glu Ser Glu  Leu Ala Asn Glu Ile  Pro Val Pro 
    1880                 1885                 1890             


Glu Thr  Leu Asp Ser Gly Ala  Leu His Ser Glu Lys  Ala Leu Gln 
    1895                 1900                 1905             


Ser Asn  His Phe Glu Leu Ser  Leu Arg Thr Glu Ala  Thr Gln Gly 
    1910                 1915                 1920             


Leu Val  Leu Trp Ser Gly Lys  Ala Thr Glu Arg Ala  Asp Tyr Val 
    1925                 1930                 1935             


Ala Leu  Ala Ile Val Asp Gly  His Leu Gln Leu Ser  Tyr Asn Leu 
    1940                 1945                 1950             


Gly Ser  Gln Pro Val Val Leu  Arg Ser Thr Val Pro  Val Asn Thr 
    1955                 1960                 1965             


Asn Arg  Trp Leu Arg Val Val  Ala His Arg Glu Gln  Arg Glu Gly 
    1970                 1975                 1980             


Ser Leu  Gln Val Gly Asn Glu  Ala Pro Val Thr Gly  Ser Ser Pro 
    1985                 1990                 1995             


Leu Gly  Ala Thr Gln Leu Asp  Thr Asp Gly Ala Leu  Trp Leu Gly 
    2000                 2005                 2010             


Gly Leu  Pro Glu Leu Pro Val  Gly Pro Ala Leu Pro  Lys Ala Tyr 
    2015                 2020                 2025             


Gly Thr  Gly Phe Val Gly Cys  Leu Arg Asp Val Val  Val Gly Arg 
    2030                 2035                 2040             


His Pro  Leu His Leu Leu Glu  Asp Ala Val Thr Lys  Pro Glu Leu 
    2045                 2050                 2055             


Arg Pro  Cys Pro Thr Pro 
    2060                 


<210>  11
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence corresponding to amino acid residues 
       1260-2045 of human wild type agrin

<400>  11

Ala Thr Ser Gly Ala Ile Ala Ala Gly Ala Thr Ala Arg Ala Thr Thr 
1               5                   10                  15      


Ala Ser Arg Leu Pro Ser Ser Ala Val Thr Pro Arg Ala Pro His Pro 
            20                  25                  30          


Ser His Thr Ser Gln Pro Val Ala Lys Thr Thr Ala Ala Pro Thr Thr 
        35                  40                  45              


Arg Arg Pro Pro Thr Thr Ala Pro Ser Arg Val Pro Gly Arg Arg Pro 
    50                  55                  60                  


Pro Ala Pro Gln Gln Pro Pro Lys Pro Cys Asp Ser Gln Pro Cys Phe 
65                  70                  75                  80  


His Gly Gly Thr Cys Gln Asp Trp Ala Leu Gly Gly Gly Phe Thr Cys 
                85                  90                  95      


Ser Cys Pro Ala Gly Arg Gly Gly Ala Val Cys Glu Lys Val Leu Gly 
            100                 105                 110         


Ala Pro Val Pro Ala Phe Glu Gly Arg Ser Phe Leu Ala Phe Pro Thr 
        115                 120                 125             


Leu Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu 
    130                 135                 140                 


Glu Pro Gln Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp 
145                 150                 155                 160 


Phe Leu Ala Leu Ala Leu Leu Asp Gly Arg Val Gln Leu Arg Phe Asp 
                165                 170                 175     


Thr Gly Ser Gly Pro Ala Val Leu Thr Ser Ala Val Pro Val Glu Pro 
            180                 185                 190         


Gly Gln Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Arg Gly Thr 
        195                 200                 205             


Leu Ser Val Asp Gly Glu Thr Pro Val Leu Gly Glu Ser Pro Ser Gly 
    210                 215                 220                 


Thr Asp Gly Leu Asn Leu Asp Thr Asp Leu Phe Val Gly Gly Val Pro 
225                 230                 235                 240 


Glu Asp Gln Ala Ala Val Ala Leu Glu Arg Thr Phe Val Gly Ala Gly 
                245                 250                 255     


Leu Arg Gly Cys Ile Arg Leu Leu Asp Val Asn Asn Gln Arg Leu Glu 
            260                 265                 270         


Leu Gly Ile Gly Pro Gly Ala Ala Thr Arg Gly Ser Gly Val Gly Glu 
        275                 280                 285             


Cys Gly Asp His Pro Cys Leu Pro Asn Pro Cys His Gly Gly Ala Pro 
    290                 295                 300                 


Cys Gln Asn Leu Glu Ala Gly Arg Phe His Cys Gln Cys Pro Pro Gly 
305                 310                 315                 320 


Arg Val Gly Pro Thr Cys Ala Asp Glu Lys Ser Pro Cys Gln Pro Asn 
                325                 330                 335     


Pro Cys His Gly Ala Ala Pro Cys Arg Val Leu Pro Glu Gly Gly Ala 
            340                 345                 350         


Gln Cys Glu Cys Pro Leu Gly Arg Glu Gly Thr Phe Cys Gln Thr Ala 
        355                 360                 365             


Ser Gly Gln Asp Gly Ser Gly Pro Phe Leu Ala Asp Phe Asn Gly Phe 
    370                 375                 380                 


Ser His Leu Glu Leu Arg Gly Leu His Thr Phe Ala Arg Asp Leu Gly 
385                 390                 395                 400 


Glu Lys Met Ala Leu Glu Val Val Phe Leu Ala Arg Gly Pro Ser Gly 
                405                 410                 415     


Leu Leu Leu Tyr Asn Gly Gln Lys Thr Asp Gly Lys Gly Asp Phe Val 
            420                 425                 430         


Ser Leu Ala Leu Arg Asp Arg Arg Leu Glu Phe Arg Tyr Asp Leu Gly 
        435                 440                 445             


Lys Gly Ala Ala Val Ile Arg Ser Arg Glu Pro Val Thr Leu Gly Ala 
    450                 455                 460                 


Trp Thr Arg Val Ser Leu Glu Arg Asn Gly Arg Lys Gly Ala Leu Arg 
465                 470                 475                 480 


Val Gly Asp Gly Pro Arg Val Leu Gly Glu Ser Pro Val Pro His Thr 
                485                 490                 495     


Val Leu Asn Leu Lys Glu Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe 
            500                 505                 510         


Ser Lys Leu Ala Arg Ala Ala Ala Val Ser Ser Gly Phe Asp Gly Ala 
        515                 520                 525             


Ile Gln Leu Val Ser Leu Gly Gly Arg Gln Leu Leu Thr Pro Glu His 
    530                 535                 540                 


Val Leu Arg Gln Val Asp Val Thr Ser Phe Ala Gly His Pro Cys Thr 
545                 550                 555                 560 


Arg Ala Ser Gly His Pro Cys Leu Asn Gly Ala Ser Cys Val Pro Arg 
                565                 570                 575     


Glu Ala Ala Tyr Val Cys Leu Cys Pro Gly Gly Phe Ser Gly Pro His 
            580                 585                 590         


Cys Glu Lys Gly Leu Val Glu Lys Ser Ala Gly Asp Val Asp Thr Leu 
        595                 600                 605             


Ala Phe Asp Gly Arg Thr Phe Val Glu Tyr Leu Asn Ala Val Thr Glu 
    610                 615                 620                 


Ser Glu Lys Ala Leu Gln Ser Asn His Phe Glu Leu Ser Leu Arg Thr 
625                 630                 635                 640 


Glu Ala Thr Gln Gly Leu Val Leu Trp Ser Gly Lys Ala Thr Glu Arg 
                645                 650                 655     


Ala Asp Tyr Val Ala Leu Ala Ile Val Asp Gly His Leu Gln Leu Ser 
            660                 665                 670         


Tyr Asn Leu Gly Ser Gln Pro Val Val Leu Arg Ser Thr Val Pro Val 
        675                 680                 685             


Asn Thr Asn Arg Trp Leu Arg Val Val Ala His Arg Glu Gln Arg Glu 
    690                 695                 700                 


Gly Ser Leu Gln Val Gly Asn Glu Ala Pro Val Thr Gly Ser Ser Pro 
705                 710                 715                 720 


Leu Gly Ala Thr Gln Leu Asp Thr Asp Gly Ala Leu Trp Leu Gly Gly 
                725                 730                 735     


Leu Pro Glu Leu Pro Val Gly Pro Ala Leu Pro Lys Ala Tyr Gly Thr 
            740                 745                 750         


Gly Phe Val Gly Cys Leu Arg Asp Val Val Val Gly Arg His Pro Leu 
        755                 760                 765             


His Leu Leu Glu Asp Ala Val Thr Lys Pro Glu Leu Arg Pro Cys Pro 
    770                 775                 780                 


Thr Pro 
785     


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of MMP3 cleavage recognition sequence

<400>  12

Pro His Thr Val Leu Asn 
1               5       


<210>  13
<211>  3936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide sequence

<400>  13
cacgtgcgat ttatggactt tgactggttt cctgcgttta tcacgggggc cacgtcagga       60

gccattgctg cgggagccac ggccagagcc accactgcat cgcgcctgcc gtcctctgct      120

gtgacccctc gggccccgca ccccagtcac acaagccagc ccgttgccaa gaccacggca      180

gcccccacca cacgtcggcc ccccaccact gcccccagcc gtgtgcccgg acgtcggccc      240

ccggcccccc agcagcctcc aaagccctgt gactcacagc cctgcttcca cggggggacc      300

tgccaggact gggcattggg cgggggcttc acctgcagct gcccggcagg caggggaggc      360

gccgtctgtg agaaggtgct tggcgcccct gtgccggcct tcgagggccg ctccttcctg      420

gccttcccca ctctccgcgc ctaccacacg ctgcgcctgg cactggaatt ccgggcgctg      480

gagcctcagg ggctgctgct gtacaatggc aacgcccggg gcaaggactt cctggcattg      540

gcgctgctag atggccgcgt gcagctcagg tttgacacag gttcggggcc ggcggtgctg      600

accagtgccg tgccggtaga gccgggccag tggcaccgcc tggagctgtc ccggcactgg      660

cgccggggca ccctctcggt ggatggtgag acccctgttc tgggcgagag tcccagtggc      720

accgacggcc tcaacctgga cacagacctc tttgtgggcg gcgtacccga ggaccaggct      780

gccgtggcgc tggagcggac cttcgtgggc gccggcctga gggggtgcat ccgtttgctg      840

gacgtcaaca accagcgcct ggagcttggc attgggccgg gggctgccac ccgaggctct      900

ggcgtgggcg agtgcgggga ccacccctgc ctgcccaacc cctgccatgg cggggcccca      960

tgccagaacc tggaggctgg aaggttccat tgccagtgcc cgcccggccg cgtcggacca     1020

acctgtgccg atgagaagag cccctgccag cccaacccct gccatggggc ggcgccctgc     1080

cgtgtgctgc ccgagggtgg tgctcagtgc gagtgccccc tggggcgtga gggcaccttc     1140

tgccagacag cctcggggca ggacggctct gggcccttcc tggctgactt caacggcttc     1200

tcccacctgg agctgagagg cctgcacacc tttgcacggg acctggggga gaagatggcg     1260

ctggaggtcg tgttcctggc acgaggcccc agcggcctcc tgctctacaa cgggcagaag     1320

acggacggca agggggactt cgtgtcgctg gcactgcggg accgccgcct ggagttccgc     1380

tacgacctgg gcaagggggc agcggtcatc aggagcaggg agccagtcac cctgggagcc     1440

tggaccaggg tctcactgga gcgaaacggc cgcaagggtg ccctgcgtgt gggcgacggc     1500

ccccgtgtgt tgggggagtc cccggttccg cacaccgtcc tcaacctgaa ggagccgctc     1560

tacgtagggg gcgctcccga cttcagcaag ctggcccgtg ctgctgccgt gtcctctggc     1620

ttcgacggtg ccatccagct ggtctccctc ggaggccgcc agctgctgac cccggagcac     1680

gtgctgcggc aggtggacgt cacgtccttt gcaggtcacc cctgcacccg ggcctcaggc     1740

cacccctgcc tcaatggggc ctcctgcgtc ccgagggagg ctgcctatgt gtgcctgtgt     1800

cccgggggat tctcaggacc gcactgcgag aaggggctgg tggagaagtc agcgggggac     1860

gtggatacct tggcctttga cgggcggacc tttgtcgagt acctcaacgc tgtgaccgag     1920

agcgagaagg cactgcagag caaccacttt gaactgagcc tgcgcactga ggccacgcag     1980

gggctggtgc tctggagtgg caaggccacg gagcgggcag actatgtggc actggccatt     2040

gtggacgggc acctgcaact gagctacaac ctgggctccc agcccgtggt gctgcgttcc     2100

accgtgcccg tcaacaccaa ccgctggttg cgggtcgtgg cacataggga gcagagggaa     2160

ggttccctgc aggtgggcaa tgaggcccct gtgaccggct cctccccgct gggcgccacg     2220

cagctggaca ctgatggagc cctgtggctt gggggcctgc cggagctgcc cgtgggccca     2280

gcactgccca aggcctacgg cacaggcttt gtgggctgct tgcgggacgt ggtggtgggc     2340

cggcacccgc tgcacctgct ggaggacgcc gtcaccaagc cagagctgcg gccctgcccc     2400

accccagacg atgacgacaa gatcatccca gttgaggagg agaacccgga cttctggaac     2460

cgcgaggcag ccgaggccct gggtgccgcc aagaagctgc agcctgcaca gacagccgcc     2520

aagaacctca tcatcttcct gggcgatggg atgggggtgt ctacggtgac agctgccagg     2580

atcctaaaag ggcagaagaa ggacaaactg gggcctgaga tacccctggc catggaccgc     2640

ttcccatatg tggctctgtc caagacatac aatgtagaca aacatgtgcc agacagtgga     2700

gccacagcca cggcctacct gtgcggggtc aagggcaact tccagaccat tggcttgagt     2760

gcagccgccc gctttaacca gtgcaacacg acacgcggca acgaggtcat ctccgtgatg     2820

aatcgggcca agaaagcagg gaagtcagtg ggagtggtaa ccaccacacg agtgcagcac     2880

gcctcgccag ccggcaccta cgcccacacg gtgaaccgca actggtactc ggacgccgac     2940

gtgcctgcct cggcccgcca ggaggggtgc caggacatcg ctacgcagct catctccaac     3000

atggacattg acgtgatcct aggtggaggc cgaaagtaca tgtttcgcat gggaacccca     3060

gaccctgagt acccagatga ctacagccaa ggtgggacca ggctggacgg gaagaatctg     3120

gtgcaggaat ggctggcgaa gcgccagggt gcccggtatg tgtggaaccg cactgagctc     3180

atgcaggctt ccctggaccc gtctgtgacc catctcatgg gtctctttga gcctggagac     3240

atgaaatacg agatccaccg agactccaca ctggacccct ccctgatgga gatgacagag     3300

gctgccctgc gcctgctgag caggaacccc cgcggcttct tcctcttcgt ggagggtggt     3360

cgcatcgacc atggtcatca tgaaagcagg gcttaccggg cactgactga gacgatcatg     3420

ttcgacgacg ccattgagag ggcgggccag ctcaccagcg aggaggacac gctgagcctc     3480

gtcactgccg accactccca cgtcttctcc ttcggaggct accccctgcg agggagctcc     3540

atcttcgggc tggcccctgg caaggcccgg gacaggaagg cctacacggt cctcctatac     3600

ggaaacggtc caggctatgt gctcaaggac ggcgcccggc cggatgttac cgagagcgag     3660

agcgggagcc ccgagtatcg gcagcagtca gcagtgcccc tggacgaaga gacccacgca     3720

ggcgaggacg tggcggtgtt cgcgcgcggc ccgcaggcgc acctggttca cggcgtgcag     3780

gagcagacct tcatagcgca cgtcatggcc ttcgccgcct gcctggagcc ctacaccgcc     3840

tgcgacctgg cgccccccgc cggcaccacc gacgccgcgc acccgggtga acaaaaactc     3900

atctcagaag aggatctgca tcaccatcac catcac                               3936


<210>  14
<211>  1312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence

<400>  14

His Val Arg Phe Met Asp Phe Asp Trp Phe Pro Ala Phe Ile Thr Gly 
1               5                   10                  15      


Ala Thr Ser Gly Ala Ile Ala Ala Gly Ala Thr Ala Arg Ala Thr Thr 
            20                  25                  30          


Ala Ser Arg Leu Pro Ser Ser Ala Val Thr Pro Arg Ala Pro His Pro 
        35                  40                  45              


Ser His Thr Ser Gln Pro Val Ala Lys Thr Thr Ala Ala Pro Thr Thr 
    50                  55                  60                  


Arg Arg Pro Pro Thr Thr Ala Pro Ser Arg Val Pro Gly Arg Arg Pro 
65                  70                  75                  80  


Pro Ala Pro Gln Gln Pro Pro Lys Pro Cys Asp Ser Gln Pro Cys Phe 
                85                  90                  95      


His Gly Gly Thr Cys Gln Asp Trp Ala Leu Gly Gly Gly Phe Thr Cys 
            100                 105                 110         


Ser Cys Pro Ala Gly Arg Gly Gly Ala Val Cys Glu Lys Val Leu Gly 
        115                 120                 125             


Ala Pro Val Pro Ala Phe Glu Gly Arg Ser Phe Leu Ala Phe Pro Thr 
    130                 135                 140                 


Leu Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu 
145                 150                 155                 160 


Glu Pro Gln Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp 
                165                 170                 175     


Phe Leu Ala Leu Ala Leu Leu Asp Gly Arg Val Gln Leu Arg Phe Asp 
            180                 185                 190         


Thr Gly Ser Gly Pro Ala Val Leu Thr Ser Ala Val Pro Val Glu Pro 
        195                 200                 205             


Gly Gln Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Arg Gly Thr 
    210                 215                 220                 


Leu Ser Val Asp Gly Glu Thr Pro Val Leu Gly Glu Ser Pro Ser Gly 
225                 230                 235                 240 


Thr Asp Gly Leu Asn Leu Asp Thr Asp Leu Phe Val Gly Gly Val Pro 
                245                 250                 255     


Glu Asp Gln Ala Ala Val Ala Leu Glu Arg Thr Phe Val Gly Ala Gly 
            260                 265                 270         


Leu Arg Gly Cys Ile Arg Leu Leu Asp Val Asn Asn Gln Arg Leu Glu 
        275                 280                 285             


Leu Gly Ile Gly Pro Gly Ala Ala Thr Arg Gly Ser Gly Val Gly Glu 
    290                 295                 300                 


Cys Gly Asp His Pro Cys Leu Pro Asn Pro Cys His Gly Gly Ala Pro 
305                 310                 315                 320 


Cys Gln Asn Leu Glu Ala Gly Arg Phe His Cys Gln Cys Pro Pro Gly 
                325                 330                 335     


Arg Val Gly Pro Thr Cys Ala Asp Glu Lys Ser Pro Cys Gln Pro Asn 
            340                 345                 350         


Pro Cys His Gly Ala Ala Pro Cys Arg Val Leu Pro Glu Gly Gly Ala 
        355                 360                 365             


Gln Cys Glu Cys Pro Leu Gly Arg Glu Gly Thr Phe Cys Gln Thr Ala 
    370                 375                 380                 


Ser Gly Gln Asp Gly Ser Gly Pro Phe Leu Ala Asp Phe Asn Gly Phe 
385                 390                 395                 400 


Ser His Leu Glu Leu Arg Gly Leu His Thr Phe Ala Arg Asp Leu Gly 
                405                 410                 415     


Glu Lys Met Ala Leu Glu Val Val Phe Leu Ala Arg Gly Pro Ser Gly 
            420                 425                 430         


Leu Leu Leu Tyr Asn Gly Gln Lys Thr Asp Gly Lys Gly Asp Phe Val 
        435                 440                 445             


Ser Leu Ala Leu Arg Asp Arg Arg Leu Glu Phe Arg Tyr Asp Leu Gly 
    450                 455                 460                 


Lys Gly Ala Ala Val Ile Arg Ser Arg Glu Pro Val Thr Leu Gly Ala 
465                 470                 475                 480 


Trp Thr Arg Val Ser Leu Glu Arg Asn Gly Arg Lys Gly Ala Leu Arg 
                485                 490                 495     


Val Gly Asp Gly Pro Arg Val Leu Gly Glu Ser Pro Val Pro His Thr 
            500                 505                 510         


Val Leu Asn Leu Lys Glu Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe 
        515                 520                 525             


Ser Lys Leu Ala Arg Ala Ala Ala Val Ser Ser Gly Phe Asp Gly Ala 
    530                 535                 540                 


Ile Gln Leu Val Ser Leu Gly Gly Arg Gln Leu Leu Thr Pro Glu His 
545                 550                 555                 560 


Val Leu Arg Gln Val Asp Val Thr Ser Phe Ala Gly His Pro Cys Thr 
                565                 570                 575     


Arg Ala Ser Gly His Pro Cys Leu Asn Gly Ala Ser Cys Val Pro Arg 
            580                 585                 590         


Glu Ala Ala Tyr Val Cys Leu Cys Pro Gly Gly Phe Ser Gly Pro His 
        595                 600                 605             


Cys Glu Lys Gly Leu Val Glu Lys Ser Ala Gly Asp Val Asp Thr Leu 
    610                 615                 620                 


Ala Phe Asp Gly Arg Thr Phe Val Glu Tyr Leu Asn Ala Val Thr Glu 
625                 630                 635                 640 


Ser Glu Lys Ala Leu Gln Ser Asn His Phe Glu Leu Ser Leu Arg Thr 
                645                 650                 655     


Glu Ala Thr Gln Gly Leu Val Leu Trp Ser Gly Lys Ala Thr Glu Arg 
            660                 665                 670         


Ala Asp Tyr Val Ala Leu Ala Ile Val Asp Gly His Leu Gln Leu Ser 
        675                 680                 685             


Tyr Asn Leu Gly Ser Gln Pro Val Val Leu Arg Ser Thr Val Pro Val 
    690                 695                 700                 


Asn Thr Asn Arg Trp Leu Arg Val Val Ala His Arg Glu Gln Arg Glu 
705                 710                 715                 720 


Gly Ser Leu Gln Val Gly Asn Glu Ala Pro Val Thr Gly Ser Ser Pro 
                725                 730                 735     


Leu Gly Ala Thr Gln Leu Asp Thr Asp Gly Ala Leu Trp Leu Gly Gly 
            740                 745                 750         


Leu Pro Glu Leu Pro Val Gly Pro Ala Leu Pro Lys Ala Tyr Gly Thr 
        755                 760                 765             


Gly Phe Val Gly Cys Leu Arg Asp Val Val Val Gly Arg His Pro Leu 
    770                 775                 780                 


His Leu Leu Glu Asp Ala Val Thr Lys Pro Glu Leu Arg Pro Cys Pro 
785                 790                 795                 800 


Thr Pro Asp Asp Asp Asp Lys Ile Ile Pro Val Glu Glu Glu Asn Pro 
                805                 810                 815     


Asp Phe Trp Asn Arg Glu Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys 
            820                 825                 830         


Leu Gln Pro Ala Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly 
        835                 840                 845             


Asp Gly Met Gly Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly 
    850                 855                 860                 


Gln Lys Lys Asp Lys Leu Gly Pro Glu Ile Pro Leu Ala Met Asp Arg 
865                 870                 875                 880 


Phe Pro Tyr Val Ala Leu Ser Lys Thr Tyr Asn Val Asp Lys His Val 
                885                 890                 895     


Pro Asp Ser Gly Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly 
            900                 905                 910         


Asn Phe Gln Thr Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys 
        915                 920                 925             


Asn Thr Thr Arg Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys 
    930                 935                 940                 


Lys Ala Gly Lys Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His 
945                 950                 955                 960 


Ala Ser Pro Ala Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr 
                965                 970                 975     


Ser Asp Ala Asp Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp 
            980                 985                 990         


Ile Ala Thr Gln Leu Ile Ser Asn  Met Asp Ile Asp Val  Ile Leu Gly 
        995                 1000                 1005             


Gly Gly  Arg Lys Tyr Met Phe  Arg Met Gly Thr Pro  Asp Pro Glu 
    1010                 1015                 1020             


Tyr Pro  Asp Asp Tyr Ser Gln  Gly Gly Thr Arg Leu  Asp Gly Lys 
    1025                 1030                 1035             


Asn Leu  Val Gln Glu Trp Leu  Ala Lys Arg Gln Gly  Ala Arg Tyr 
    1040                 1045                 1050             


Val Trp  Asn Arg Thr Glu Leu  Met Gln Ala Ser Leu  Asp Pro Ser 
    1055                 1060                 1065             


Val Thr  His Leu Met Gly Leu  Phe Glu Pro Gly Asp  Met Lys Tyr 
    1070                 1075                 1080             


Glu Ile  His Arg Asp Ser Thr  Leu Asp Pro Ser Leu  Met Glu Met 
    1085                 1090                 1095             


Thr Glu  Ala Ala Leu Arg Leu  Leu Ser Arg Asn Pro  Arg Gly Phe 
    1100                 1105                 1110             


Phe Leu  Phe Val Glu Gly Gly  Arg Ile Asp His Gly  His His Glu 
    1115                 1120                 1125             


Ser Arg  Ala Tyr Arg Ala Leu  Thr Glu Thr Ile Met  Phe Asp Asp 
    1130                 1135                 1140             


Ala Ile  Glu Arg Ala Gly Gln  Leu Thr Ser Glu Glu  Asp Thr Leu 
    1145                 1150                 1155             


Ser Leu  Val Thr Ala Asp His  Ser His Val Phe Ser  Phe Gly Gly 
    1160                 1165                 1170             


Tyr Pro  Leu Arg Gly Ser Ser  Ile Phe Gly Leu Ala  Pro Gly Lys 
    1175                 1180                 1185             


Ala Arg  Asp Arg Lys Ala Tyr  Thr Val Leu Leu Tyr  Gly Asn Gly 
    1190                 1195                 1200             


Pro Gly  Tyr Val Leu Lys Asp  Gly Ala Arg Pro Asp  Val Thr Glu 
    1205                 1210                 1215             


Ser Glu  Ser Gly Ser Pro Glu  Tyr Arg Gln Gln Ser  Ala Val Pro 
    1220                 1225                 1230             


Leu Asp  Glu Glu Thr His Ala  Gly Glu Asp Val Ala  Val Phe Ala 
    1235                 1240                 1245             


Arg Gly  Pro Gln Ala His Leu  Val His Gly Val Gln  Glu Gln Thr 
    1250                 1255                 1260             


Phe Ile  Ala His Val Met Ala  Phe Ala Ala Cys Leu  Glu Pro Tyr 
    1265                 1270                 1275             


Thr Ala  Cys Asp Leu Ala Pro  Pro Ala Gly Thr Thr  Asp Ala Ala 
    1280                 1285                 1290             


His Pro  Gly Glu Gln Lys Leu  Ile Ser Glu Glu Asp  Leu His His 
    1295                 1300                 1305             


His His  His His 
    1310         


<210>  15
<211>  2406
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide sequence

<400>  15
cacgtgcgat ttatggactt tgactggttt cctgcgttta tcacgggggc cacgtcagga       60

gccattgctg cgggagccac ggccagagcc accactgcat cgcgcctgcc gtcctctgct      120

gtgacccctc gggccccgca ccccagtcac acaagccagc ccgttgccaa gaccacggca      180

gcccccacca cacgtcggcc ccccaccact gcccccagcc gtgtgcccgg acgtcggccc      240

ccggcccccc agcagcctcc aaagccctgt gactcacagc cctgcttcca cggggggacc      300

tgccaggact gggcattggg cgggggcttc acctgcagct gcccggcagg caggggaggc      360

gccgtctgtg agaaggtgct tggcgcccct gtgccggcct tcgagggccg ctccttcctg      420

gccttcccca ctctccgcgc ctaccacacg ctgcgcctgg cactggaatt ccgggcgctg      480

gagcctcagg ggctgctgct gtacaatggc aacgcccggg gcaaggactt cctggcattg      540

gcgctgctag atggccgcgt gcagctcagg tttgacacag gttcggggcc ggcggtgctg      600

accagtgccg tgccggtaga gccgggccag tggcaccgcc tggagctgtc ccggcactgg      660

cgccggggca ccctctcggt ggatggtgag acccctgttc tgggcgagag tcccagtggc      720

accgacggcc tcaacctgga cacagacctc tttgtgggcg gcgtacccga ggaccaggct      780

gccgtggcgc tggagcggac cttcgtgggc gccggcctga gggggtgcat ccgtttgctg      840

gacgtcaaca accagcgcct ggagcttggc attgggccgg gggctgccac ccgaggctct      900

ggcgtgggcg agtgcgggga ccacccctgc ctgcccaacc cctgccatgg cggggcccca      960

tgccagaacc tggaggctgg aaggttccat tgccagtgcc cgcccggccg cgtcggacca     1020

acctgtgccg atgagaagag cccctgccag cccaacccct gccatggggc ggcgccctgc     1080

cgtgtgctgc ccgagggtgg tgctcagtgc gagtgccccc tggggcgtga gggcaccttc     1140

tgccagacag cctcggggca ggacggctct gggcccttcc tggctgactt caacggcttc     1200

tcccacctgg agctgagagg cctgcacacc tttgcacggg acctggggga gaagatggcg     1260

ctggaggtcg tgttcctggc acgaggcccc agcggcctcc tgctctacaa cgggcagaag     1320

acggacggca agggggactt cgtgtcgctg gcactgcggg accgccgcct ggagttccgc     1380

tacgacctgg gcaagggggc agcggtcatc aggagcaggg agccagtcac cctgggagcc     1440

tggaccaggg tctcactgga gcgaaacggc cgcaagggtg ccctgcgtgt gggcgacggc     1500

ccccgtgtgt tgggggagtc cccggttccg cacaccgtcc tcaacctgaa ggagccgctc     1560

tacgtagggg gcgctcccga cttcagcaag ctggcccgtg ctgctgccgt gtcctctggc     1620

ttcgacggtg ccatccagct ggtctccctc ggaggccgcc agctgctgac cccggagcac     1680

gtgctgcggc aggtggacgt cacgtccttt gcaggtcacc cctgcacccg ggcctcaggc     1740

cacccctgcc tcaatggggc ctcctgcgtc ccgagggagg ctgcctatgt gtgcctgtgt     1800

cccgggggat tctcaggacc gcactgcgag aaggggctgg tggagaagtc agcgggggac     1860

gtggatacct tggcctttga cgggcggacc tttgtcgagt acctcaacgc tgtgaccgag     1920

agcgagaagg cactgcagag caaccacttt gaactgagcc tgcgcactga ggccacgcag     1980

gggctggtgc tctggagtgg caaggccacg gagcgggcag actatgtggc actggccatt     2040

gtggacgggc acctgcaact gagctacaac ctgggctccc agcccgtggt gctgcgttcc     2100

accgtgcccg tcaacaccaa ccgctggttg cgggtcgtgg cacataggga gcagagggaa     2160

ggttccctgc aggtgggcaa tgaggcccct gtgaccggct cctccccgct gggcgccacg     2220

cagctggaca ctgatggagc cctgtggctt gggggcctgc cggagctgcc cgtgggccca     2280

gcactgccca aggcctacgg cacaggcttt gtgggctgct tgcgggacgt ggtggtgggc     2340

cggcacccgc tgcacctgct ggaggacgcc gtcaccaagc cagagctgcg gccctgcccc     2400

acccca                                                                2406


<210>  16
<211>  3948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide sequence

<400>  16
cacgtgcgat ttatggactt tgactggttt cctgcgttta tcacgggggc cacgtcagga       60

gccattgctg cgggagccac ggccagagcc accactgcat cgcgcctgcc gtcctctgct      120

gtgacccctc gggccccgca ccccagtcac acaagccagc ccgttgccaa gaccacggca      180

gcccccacca cacgtcggcc ccccaccact gcccccagcc gtgtgcccgg acgtcggccc      240

ccggcccccc agcagcctcc aaagccctgt gactcacagc cctgcttcca cggggggacc      300

tgccaggact gggcattggg cgggggcttc acctgcagct gcccggcagg caggggaggc      360

gccgtctgtg agaaggtgct tggcgcccct gtgccggcct tcgagggccg ctccttcctg      420

gccttcccca ctctccgcgc ctaccacacg ctgcgcctgg cactggaatt ccgggcgctg      480

gagcctcagg ggctgctgct gtacaatggc aacgcccggg gcaaggactt cctggcattg      540

gcgctgctag atggccgcgt gcagctcagg tttgacacag gttcggggcc ggcggtgctg      600

accagtgccg tgccggtaga gccgggccag tggcaccgcc tggagctgtc ccggcactgg      660

cgccggggca ccctctcggt ggatggtgag acccctgttc tgggcgagag tcccagtggc      720

accgacggcc tcaacctgga cacagacctc tttgtgggcg gcgtacccga ggaccaggct      780

gccgtggcgc tggagcggac cttcgtgggc gccggcctga gggggtgcat ccgtttgctg      840

gacgtcaaca accagcgcct ggagcttggc attgggccgg gggctgccac ccgaggctct      900

ggcgtgggcg agtgcgggga ccacccctgc ctgcccaacc cctgccatgg cggggcccca      960

tgccagaacc tggaggctgg aaggttccat tgccagtgcc cgcccggccg cgtcggacca     1020

acctgtgccg atgagaagag cccctgccag cccaacccct gccatggggc ggcgccctgc     1080

cgtgtgctgc ccgagggtgg tgctcagtgc gagtgccccc tggggcgtga gggcaccttc     1140

tgccagacag cctcggggca ggacggctct gggcccttcc tggctgactt caacggcttc     1200

tcccacctgg agctgagagg cctgcacacc tttgcacggg acctggggga gaagatggcg     1260

ctggaggtcg tgttcctggc acgaggcccc agcggcctcc tgctctacaa cgggcagaag     1320

acggacggca agggggactt cgtgtcgctg gcactgcggg accgccgcct ggagttccgc     1380

tacgacctgg gcaagggggc agcggtcatc aggagcaggg agccagtcac cctgggagcc     1440

tggaccaggg tctcactgga gcgaaacggc cgcaagggtg ccctgcgtgt gggcgacggc     1500

ccccgtgtgt tgggggagtc cccggttccg gggggggggc tcaacctgaa ggagccgctc     1560

tacgtagggg gcgctcccga cttcagcaag ctggcccgtg ctgctgccgt gtcctctggc     1620

ttcgacggtg ccatccagct ggtctccctc ggaggccgcc agctgctgac cccggagcac     1680

gtgctgcggc aggtggacgt cacgtccttt gcaggtcacc cctgcacccg ggcctcaggc     1740

cacccctgcc tcaatggggc ctcctgcgtc ccgagggagg ctgcctatgt gtgcctgtgt     1800

cccgggggat tctcaggacc gcactgcgag aaggggctgg tggagaagtc agcgggggac     1860

gtggatacct tggcctttga cgggcggacc tttgtcgagt acctcaacgc tgtgaccgag     1920

agcgagaagg cactgcagag caaccacttt gaactgagcc tgcgcactga ggccacgcag     1980

gggctggtgc tctggagtgg caaggccacg gagcgggcag actatgtggc actggccatt     2040

gtggacgggc acctgcaact gagctacaac ctgggctccc agcccgtggt gctgcgttcc     2100

accgtgcccg tcaacaccaa ccgctggttg cgggtcgtgg cacataggga gcagagggaa     2160

ggttccctgc aggtgggcaa tgaggcccct gtgaccggct cctccccgct gggcgccacg     2220

cagctggaca ctgatggagc cctgtggctt gggggcctgc cggagctgcc cgtgggccca     2280

gcactgccca aggcctacgg cacaggcttt gtgggctgct tgcgggacgt ggtggtgggc     2340

cggcacccgc tgcacctgct ggaggacgcc gtcaccaagc cagagctgcg gccctgcccc     2400

accccagacg atgacgacaa gatcatccca gttgaggagg agaacccgga cttctggaac     2460

cgcgaggcag ccgaggccct gggtgccgcc aagaagctgc agcctgcaca gacagccgcc     2520

aagaacctca tcatcttcct gggcgatggg atgggggtgt ctacggtgac agctgccagg     2580

atcctaaaag ggcagaagaa ggacaaactg gggcctgaga tacccctggc catggaccgc     2640

ttcccatatg tggctctgtc caagacatac aatgtagaca aacatgtgcc agacagtgga     2700

gccacagcca cggcctacct gtgcggggtc aagggcaact tccagaccat tggcttgagt     2760

gcagccgccc gctttaacca gtgcaacacg acacgcggca acgaggtcat ctccgtgatg     2820

aatcgggcca agaaagcagg gaagtcagtg ggagtggtaa ccaccacacg agtgcagcac     2880

gcctcgccag ccggcaccta cgcccacacg gtgaaccgca actggtactc ggacgccgac     2940

gtgcctgcct cggcccgcca ggaggggtgc caggacatcg ctacgcagct catctccaac     3000

atggacattg acgtgatcct aggtggaggc cgaaagtaca tgtttcgcat gggaacccca     3060

gaccctgagt acccagatga ctacagccaa ggtgggacca ggctggacgg gaagaatctg     3120

gtgcaggaat ggctggcgaa gcgccagggt gcccggtatg tgtggaaccg cactgagctc     3180

atgcaggctt ccctggaccc gtctgtgacc catctcatgg gtctctttga gcctggagac     3240

atgaaatacg agatccaccg agactccaca ctggacccct ccctgatgga gatgacagag     3300

gctgccctgc gcctgctgag caggaacccc cgcggcttct tcctcttcgt ggagggtggt     3360

cgcatcgacc atggtcatca tgaaagcagg gcttaccggg cactgactga gacgatcatg     3420

ttcgacgacg ccattgagag ggcgggccag ctcaccagcg aggaggacac gctgagcctc     3480

gtcactgccg accactccca cgtcttctcc ttcggaggct accccctgcg agggagctcc     3540

atcttcgggc tggcccctgg caaggcccgg gacaggaagg cctacacggt cctcctatac     3600

ggaaacggtc caggctatgt gctcaaggac ggcgcccggc cggatgttac cgagagcgag     3660

agcgggagcc ccgagtatcg gcagcagtca gcagtgcccc tggacgaaga gacccacgca     3720

ggcgaggacg tggcggtgtt cgcgcgcggc ccgcaggcgc acctggttca cggcgtgcag     3780

gagcagacct tcatagcgca cgtcatggcc ttcgccgcct gcctggagcc ctacaccgcc     3840

tgcgacctgg cgccccccgc cggcaccacc gacgccgcgc acccgggtga acaaaaactc     3900

atctcagaag aggatctgca ccaccaccat caccatcatc accaccac                  3948


<210>  17
<211>  1316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence

<400>  17

His Val Arg Phe Met Asp Phe Asp Trp Phe Pro Ala Phe Ile Thr Gly 
1               5                   10                  15      


Ala Thr Ser Gly Ala Ile Ala Ala Gly Ala Thr Ala Arg Ala Thr Thr 
            20                  25                  30          


Ala Ser Arg Leu Pro Ser Ser Ala Val Thr Pro Arg Ala Pro His Pro 
        35                  40                  45              


Ser His Thr Ser Gln Pro Val Ala Lys Thr Thr Ala Ala Pro Thr Thr 
    50                  55                  60                  


Arg Arg Pro Pro Thr Thr Ala Pro Ser Arg Val Pro Gly Arg Arg Pro 
65                  70                  75                  80  


Pro Ala Pro Gln Gln Pro Pro Lys Pro Cys Asp Ser Gln Pro Cys Phe 
                85                  90                  95      


His Gly Gly Thr Cys Gln Asp Trp Ala Leu Gly Gly Gly Phe Thr Cys 
            100                 105                 110         


Ser Cys Pro Ala Gly Arg Gly Gly Ala Val Cys Glu Lys Val Leu Gly 
        115                 120                 125             


Ala Pro Val Pro Ala Phe Glu Gly Arg Ser Phe Leu Ala Phe Pro Thr 
    130                 135                 140                 


Leu Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu 
145                 150                 155                 160 


Glu Pro Gln Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp 
                165                 170                 175     


Phe Leu Ala Leu Ala Leu Leu Asp Gly Arg Val Gln Leu Arg Phe Asp 
            180                 185                 190         


Thr Gly Ser Gly Pro Ala Val Leu Thr Ser Ala Val Pro Val Glu Pro 
        195                 200                 205             


Gly Gln Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Arg Gly Thr 
    210                 215                 220                 


Leu Ser Val Asp Gly Glu Thr Pro Val Leu Gly Glu Ser Pro Ser Gly 
225                 230                 235                 240 


Thr Asp Gly Leu Asn Leu Asp Thr Asp Leu Phe Val Gly Gly Val Pro 
                245                 250                 255     


Glu Asp Gln Ala Ala Val Ala Leu Glu Arg Thr Phe Val Gly Ala Gly 
            260                 265                 270         


Leu Arg Gly Cys Ile Arg Leu Leu Asp Val Asn Asn Gln Arg Leu Glu 
        275                 280                 285             


Leu Gly Ile Gly Pro Gly Ala Ala Thr Arg Gly Ser Gly Val Gly Glu 
    290                 295                 300                 


Cys Gly Asp His Pro Cys Leu Pro Asn Pro Cys His Gly Gly Ala Pro 
305                 310                 315                 320 


Cys Gln Asn Leu Glu Ala Gly Arg Phe His Cys Gln Cys Pro Pro Gly 
                325                 330                 335     


Arg Val Gly Pro Thr Cys Ala Asp Glu Lys Ser Pro Cys Gln Pro Asn 
            340                 345                 350         


Pro Cys His Gly Ala Ala Pro Cys Arg Val Leu Pro Glu Gly Gly Ala 
        355                 360                 365             


Gln Cys Glu Cys Pro Leu Gly Arg Glu Gly Thr Phe Cys Gln Thr Ala 
    370                 375                 380                 


Ser Gly Gln Asp Gly Ser Gly Pro Phe Leu Ala Asp Phe Asn Gly Phe 
385                 390                 395                 400 


Ser His Leu Glu Leu Arg Gly Leu His Thr Phe Ala Arg Asp Leu Gly 
                405                 410                 415     


Glu Lys Met Ala Leu Glu Val Val Phe Leu Ala Arg Gly Pro Ser Gly 
            420                 425                 430         


Leu Leu Leu Tyr Asn Gly Gln Lys Thr Asp Gly Lys Gly Asp Phe Val 
        435                 440                 445             


Ser Leu Ala Leu Arg Asp Arg Arg Leu Glu Phe Arg Tyr Asp Leu Gly 
    450                 455                 460                 


Lys Gly Ala Ala Val Ile Arg Ser Arg Glu Pro Val Thr Leu Gly Ala 
465                 470                 475                 480 


Trp Thr Arg Val Ser Leu Glu Arg Asn Gly Arg Lys Gly Ala Leu Arg 
                485                 490                 495     


Val Gly Asp Gly Pro Arg Val Leu Gly Glu Ser Pro Val Pro Gly Gly 
            500                 505                 510         


Gly Leu Asn Leu Lys Glu Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe 
        515                 520                 525             


Ser Lys Leu Ala Arg Ala Ala Ala Val Ser Ser Gly Phe Asp Gly Ala 
    530                 535                 540                 


Ile Gln Leu Val Ser Leu Gly Gly Arg Gln Leu Leu Thr Pro Glu His 
545                 550                 555                 560 


Val Leu Arg Gln Val Asp Val Thr Ser Phe Ala Gly His Pro Cys Thr 
                565                 570                 575     


Arg Ala Ser Gly His Pro Cys Leu Asn Gly Ala Ser Cys Val Pro Arg 
            580                 585                 590         


Glu Ala Ala Tyr Val Cys Leu Cys Pro Gly Gly Phe Ser Gly Pro His 
        595                 600                 605             


Cys Glu Lys Gly Leu Val Glu Lys Ser Ala Gly Asp Val Asp Thr Leu 
    610                 615                 620                 


Ala Phe Asp Gly Arg Thr Phe Val Glu Tyr Leu Asn Ala Val Thr Glu 
625                 630                 635                 640 


Ser Glu Lys Ala Leu Gln Ser Asn His Phe Glu Leu Ser Leu Arg Thr 
                645                 650                 655     


Glu Ala Thr Gln Gly Leu Val Leu Trp Ser Gly Lys Ala Thr Glu Arg 
            660                 665                 670         


Ala Asp Tyr Val Ala Leu Ala Ile Val Asp Gly His Leu Gln Leu Ser 
        675                 680                 685             


Tyr Asn Leu Gly Ser Gln Pro Val Val Leu Arg Ser Thr Val Pro Val 
    690                 695                 700                 


Asn Thr Asn Arg Trp Leu Arg Val Val Ala His Arg Glu Gln Arg Glu 
705                 710                 715                 720 


Gly Ser Leu Gln Val Gly Asn Glu Ala Pro Val Thr Gly Ser Ser Pro 
                725                 730                 735     


Leu Gly Ala Thr Gln Leu Asp Thr Asp Gly Ala Leu Trp Leu Gly Gly 
            740                 745                 750         


Leu Pro Glu Leu Pro Val Gly Pro Ala Leu Pro Lys Ala Tyr Gly Thr 
        755                 760                 765             


Gly Phe Val Gly Cys Leu Arg Asp Val Val Val Gly Arg His Pro Leu 
    770                 775                 780                 


His Leu Leu Glu Asp Ala Val Thr Lys Pro Glu Leu Arg Pro Cys Pro 
785                 790                 795                 800 


Thr Pro Asp Asp Asp Asp Lys Ile Ile Pro Val Glu Glu Glu Asn Pro 
                805                 810                 815     


Asp Phe Trp Asn Arg Glu Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys 
            820                 825                 830         


Leu Gln Pro Ala Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly 
        835                 840                 845             


Asp Gly Met Gly Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly 
    850                 855                 860                 


Gln Lys Lys Asp Lys Leu Gly Pro Glu Ile Pro Leu Ala Met Asp Arg 
865                 870                 875                 880 


Phe Pro Tyr Val Ala Leu Ser Lys Thr Tyr Asn Val Asp Lys His Val 
                885                 890                 895     


Pro Asp Ser Gly Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly 
            900                 905                 910         


Asn Phe Gln Thr Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys 
        915                 920                 925             


Asn Thr Thr Arg Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys 
    930                 935                 940                 


Lys Ala Gly Lys Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His 
945                 950                 955                 960 


Ala Ser Pro Ala Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr 
                965                 970                 975     


Ser Asp Ala Asp Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp 
            980                 985                 990         


Ile Ala Thr Gln Leu Ile Ser Asn  Met Asp Ile Asp Val  Ile Leu Gly 
        995                 1000                 1005             


Gly Gly  Arg Lys Tyr Met Phe  Arg Met Gly Thr Pro  Asp Pro Glu 
    1010                 1015                 1020             


Tyr Pro  Asp Asp Tyr Ser Gln  Gly Gly Thr Arg Leu  Asp Gly Lys 
    1025                 1030                 1035             


Asn Leu  Val Gln Glu Trp Leu  Ala Lys Arg Gln Gly  Ala Arg Tyr 
    1040                 1045                 1050             


Val Trp  Asn Arg Thr Glu Leu  Met Gln Ala Ser Leu  Asp Pro Ser 
    1055                 1060                 1065             


Val Thr  His Leu Met Gly Leu  Phe Glu Pro Gly Asp  Met Lys Tyr 
    1070                 1075                 1080             


Glu Ile  His Arg Asp Ser Thr  Leu Asp Pro Ser Leu  Met Glu Met 
    1085                 1090                 1095             


Thr Glu  Ala Ala Leu Arg Leu  Leu Ser Arg Asn Pro  Arg Gly Phe 
    1100                 1105                 1110             


Phe Leu  Phe Val Glu Gly Gly  Arg Ile Asp His Gly  His His Glu 
    1115                 1120                 1125             


Ser Arg  Ala Tyr Arg Ala Leu  Thr Glu Thr Ile Met  Phe Asp Asp 
    1130                 1135                 1140             


Ala Ile  Glu Arg Ala Gly Gln  Leu Thr Ser Glu Glu  Asp Thr Leu 
    1145                 1150                 1155             


Ser Leu  Val Thr Ala Asp His  Ser His Val Phe Ser  Phe Gly Gly 
    1160                 1165                 1170             


Tyr Pro  Leu Arg Gly Ser Ser  Ile Phe Gly Leu Ala  Pro Gly Lys 
    1175                 1180                 1185             


Ala Arg  Asp Arg Lys Ala Tyr  Thr Val Leu Leu Tyr  Gly Asn Gly 
    1190                 1195                 1200             


Pro Gly  Tyr Val Leu Lys Asp  Gly Ala Arg Pro Asp  Val Thr Glu 
    1205                 1210                 1215             


Ser Glu  Ser Gly Ser Pro Glu  Tyr Arg Gln Gln Ser  Ala Val Pro 
    1220                 1225                 1230             


Leu Asp  Glu Glu Thr His Ala  Gly Glu Asp Val Ala  Val Phe Ala 
    1235                 1240                 1245             


Arg Gly  Pro Gln Ala His Leu  Val His Gly Val Gln  Glu Gln Thr 
    1250                 1255                 1260             


Phe Ile  Ala His Val Met Ala  Phe Ala Ala Cys Leu  Glu Pro Tyr 
    1265                 1270                 1275             


Thr Ala  Cys Asp Leu Ala Pro  Pro Ala Gly Thr Thr  Asp Ala Ala 
    1280                 1285                 1290             


His Pro  Gly Glu Gln Lys Leu  Ile Ser Glu Glu Asp  Leu His His 
    1295                 1300                 1305             


His His  His His His His His  His 
    1310                 1315     


<210>  18
<211>  2406
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide sequence

<400>  18
cacgtgcgat ttatggactt tgactggttt cctgcgttta tcacgggggc cacgtcagga       60

gccattgctg cgggagccac ggccagagcc accactgcat cgcgcctgcc gtcctctgct      120

gtgacccctc gggccccgca ccccagtcac acaagccagc ccgttgccaa gaccacggca      180

gcccccacca cacgtcggcc ccccaccact gcccccagcc gtgtgcccgg acgtcggccc      240

ccggcccccc agcagcctcc aaagccctgt gactcacagc cctgcttcca cggggggacc      300

tgccaggact gggcattggg cgggggcttc acctgcagct gcccggcagg caggggaggc      360

gccgtctgtg agaaggtgct tggcgcccct gtgccggcct tcgagggccg ctccttcctg      420

gccttcccca ctctccgcgc ctaccacacg ctgcgcctgg cactggaatt ccgggcgctg      480

gagcctcagg ggctgctgct gtacaatggc aacgcccggg gcaaggactt cctggcattg      540

gcgctgctag atggccgcgt gcagctcagg tttgacacag gttcggggcc ggcggtgctg      600

accagtgccg tgccggtaga gccgggccag tggcaccgcc tggagctgtc ccggcactgg      660

cgccggggca ccctctcggt ggatggtgag acccctgttc tgggcgagag tcccagtggc      720

accgacggcc tcaacctgga cacagacctc tttgtgggcg gcgtacccga ggaccaggct      780

gccgtggcgc tggagcggac cttcgtgggc gccggcctga gggggtgcat ccgtttgctg      840

gacgtcaaca accagcgcct ggagcttggc attgggccgg gggctgccac ccgaggctct      900

ggcgtgggcg agtgcgggga ccacccctgc ctgcccaacc cctgccatgg cggggcccca      960

tgccagaacc tggaggctgg aaggttccat tgccagtgcc cgcccggccg cgtcggacca     1020

acctgtgccg atgagaagag cccctgccag cccaacccct gccatggggc ggcgccctgc     1080

cgtgtgctgc ccgagggtgg tgctcagtgc gagtgccccc tggggcgtga gggcaccttc     1140

tgccagacag cctcggggca ggacggctct gggcccttcc tggctgactt caacggcttc     1200

tcccacctgg agctgagagg cctgcacacc tttgcacggg acctggggga gaagatggcg     1260

ctggaggtcg tgttcctggc acgaggcccc agcggcctcc tgctctacaa cgggcagaag     1320

acggacggca agggggactt cgtgtcgctg gcactgcggg accgccgcct ggagttccgc     1380

tacgacctgg gcaagggggc agcggtcatc aggagcaggg agccagtcac cctgggagcc     1440

tggaccaggg tctcactgga gcgaaacggc cgcaagggtg ccctgcgtgt gggcgacggc     1500

ccccgtgtgt tgggggagtc cccggttccg gggggggggc tcaacctgaa ggagccgctc     1560

tacgtagggg gcgctcccga cttcagcaag ctggcccgtg ctgctgccgt gtcctctggc     1620

ttcgacggtg ccatccagct ggtctccctc ggaggccgcc agctgctgac cccggagcac     1680

gtgctgcggc aggtggacgt cacgtccttt gcaggtcacc cctgcacccg ggcctcaggc     1740

cacccctgcc tcaatggggc ctcctgcgtc ccgagggagg ctgcctatgt gtgcctgtgt     1800

cccgggggat tctcaggacc gcactgcgag aaggggctgg tggagaagtc agcgggggac     1860

gtggatacct tggcctttga cgggcggacc tttgtcgagt acctcaacgc tgtgaccgag     1920

agcgagaagg cactgcagag caaccacttt gaactgagcc tgcgcactga ggccacgcag     1980

gggctggtgc tctggagtgg caaggccacg gagcgggcag actatgtggc actggccatt     2040

gtggacgggc acctgcaact gagctacaac ctgggctccc agcccgtggt gctgcgttcc     2100

accgtgcccg tcaacaccaa ccgctggttg cgggtcgtgg cacataggga gcagagggaa     2160

ggttccctgc aggtgggcaa tgaggcccct gtgaccggct cctccccgct gggcgccacg     2220

cagctggaca ctgatggagc cctgtggctt gggggcctgc cggagctgcc cgtgggccca     2280

gcactgccca aggcctacgg cacaggcttt gtgggctgct tgcgggacgt ggtggtgggc     2340

cggcacccgc tgcacctgct ggaggacgcc gtcaccaagc cagagctgcg gccctgcccc     2400

acccca                                                                2406


<210>  19
<211>  802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence

<400>  19

His Val Arg Phe Met Asp Phe Asp Trp Phe Pro Ala Phe Ile Thr Gly 
1               5                   10                  15      


Ala Thr Ser Gly Ala Ile Ala Ala Gly Ala Thr Ala Arg Ala Thr Thr 
            20                  25                  30          


Ala Ser Arg Leu Pro Ser Ser Ala Val Thr Pro Arg Ala Pro His Pro 
        35                  40                  45              


Ser His Thr Ser Gln Pro Val Ala Lys Thr Thr Ala Ala Pro Thr Thr 
    50                  55                  60                  


Arg Arg Pro Pro Thr Thr Ala Pro Ser Arg Val Pro Gly Arg Arg Pro 
65                  70                  75                  80  


Pro Ala Pro Gln Gln Pro Pro Lys Pro Cys Asp Ser Gln Pro Cys Phe 
                85                  90                  95      


His Gly Gly Thr Cys Gln Asp Trp Ala Leu Gly Gly Gly Phe Thr Cys 
            100                 105                 110         


Ser Cys Pro Ala Gly Arg Gly Gly Ala Val Cys Glu Lys Val Leu Gly 
        115                 120                 125             


Ala Pro Val Pro Ala Phe Glu Gly Arg Ser Phe Leu Ala Phe Pro Thr 
    130                 135                 140                 


Leu Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu 
145                 150                 155                 160 


Glu Pro Gln Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp 
                165                 170                 175     


Phe Leu Ala Leu Ala Leu Leu Asp Gly Arg Val Gln Leu Arg Phe Asp 
            180                 185                 190         


Thr Gly Ser Gly Pro Ala Val Leu Thr Ser Ala Val Pro Val Glu Pro 
        195                 200                 205             


Gly Gln Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Arg Gly Thr 
    210                 215                 220                 


Leu Ser Val Asp Gly Glu Thr Pro Val Leu Gly Glu Ser Pro Ser Gly 
225                 230                 235                 240 


Thr Asp Gly Leu Asn Leu Asp Thr Asp Leu Phe Val Gly Gly Val Pro 
                245                 250                 255     


Glu Asp Gln Ala Ala Val Ala Leu Glu Arg Thr Phe Val Gly Ala Gly 
            260                 265                 270         


Leu Arg Gly Cys Ile Arg Leu Leu Asp Val Asn Asn Gln Arg Leu Glu 
        275                 280                 285             


Leu Gly Ile Gly Pro Gly Ala Ala Thr Arg Gly Ser Gly Val Gly Glu 
    290                 295                 300                 


Cys Gly Asp His Pro Cys Leu Pro Asn Pro Cys His Gly Gly Ala Pro 
305                 310                 315                 320 


Cys Gln Asn Leu Glu Ala Gly Arg Phe His Cys Gln Cys Pro Pro Gly 
                325                 330                 335     


Arg Val Gly Pro Thr Cys Ala Asp Glu Lys Ser Pro Cys Gln Pro Asn 
            340                 345                 350         


Pro Cys His Gly Ala Ala Pro Cys Arg Val Leu Pro Glu Gly Gly Ala 
        355                 360                 365             


Gln Cys Glu Cys Pro Leu Gly Arg Glu Gly Thr Phe Cys Gln Thr Ala 
    370                 375                 380                 


Ser Gly Gln Asp Gly Ser Gly Pro Phe Leu Ala Asp Phe Asn Gly Phe 
385                 390                 395                 400 


Ser His Leu Glu Leu Arg Gly Leu His Thr Phe Ala Arg Asp Leu Gly 
                405                 410                 415     


Glu Lys Met Ala Leu Glu Val Val Phe Leu Ala Arg Gly Pro Ser Gly 
            420                 425                 430         


Leu Leu Leu Tyr Asn Gly Gln Lys Thr Asp Gly Lys Gly Asp Phe Val 
        435                 440                 445             


Ser Leu Ala Leu Arg Asp Arg Arg Leu Glu Phe Arg Tyr Asp Leu Gly 
    450                 455                 460                 


Lys Gly Ala Ala Val Ile Arg Ser Arg Glu Pro Val Thr Leu Gly Ala 
465                 470                 475                 480 


Trp Thr Arg Val Ser Leu Glu Arg Asn Gly Arg Lys Gly Ala Leu Arg 
                485                 490                 495     


Val Gly Asp Gly Pro Arg Val Leu Gly Glu Ser Pro Val Pro Gly Gly 
            500                 505                 510         


Gly Leu Asn Leu Lys Glu Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe 
        515                 520                 525             


Ser Lys Leu Ala Arg Ala Ala Ala Val Ser Ser Gly Phe Asp Gly Ala 
    530                 535                 540                 


Ile Gln Leu Val Ser Leu Gly Gly Arg Gln Leu Leu Thr Pro Glu His 
545                 550                 555                 560 


Val Leu Arg Gln Val Asp Val Thr Ser Phe Ala Gly His Pro Cys Thr 
                565                 570                 575     


Arg Ala Ser Gly His Pro Cys Leu Asn Gly Ala Ser Cys Val Pro Arg 
            580                 585                 590         


Glu Ala Ala Tyr Val Cys Leu Cys Pro Gly Gly Phe Ser Gly Pro His 
        595                 600                 605             


Cys Glu Lys Gly Leu Val Glu Lys Ser Ala Gly Asp Val Asp Thr Leu 
    610                 615                 620                 


Ala Phe Asp Gly Arg Thr Phe Val Glu Tyr Leu Asn Ala Val Thr Glu 
625                 630                 635                 640 


Ser Glu Lys Ala Leu Gln Ser Asn His Phe Glu Leu Ser Leu Arg Thr 
                645                 650                 655     


Glu Ala Thr Gln Gly Leu Val Leu Trp Ser Gly Lys Ala Thr Glu Arg 
            660                 665                 670         


Ala Asp Tyr Val Ala Leu Ala Ile Val Asp Gly His Leu Gln Leu Ser 
        675                 680                 685             


Tyr Asn Leu Gly Ser Gln Pro Val Val Leu Arg Ser Thr Val Pro Val 
    690                 695                 700                 


Asn Thr Asn Arg Trp Leu Arg Val Val Ala His Arg Glu Gln Arg Glu 
705                 710                 715                 720 


Gly Ser Leu Gln Val Gly Asn Glu Ala Pro Val Thr Gly Ser Ser Pro 
                725                 730                 735     


Leu Gly Ala Thr Gln Leu Asp Thr Asp Gly Ala Leu Trp Leu Gly Gly 
            740                 745                 750         


Leu Pro Glu Leu Pro Val Gly Pro Ala Leu Pro Lys Ala Tyr Gly Thr 
        755                 760                 765             


Gly Phe Val Gly Cys Leu Arg Asp Val Val Val Gly Arg His Pro Leu 
    770                 775                 780                 


His Leu Leu Glu Asp Ala Val Thr Lys Pro Glu Leu Arg Pro Cys Pro 
785                 790                 795                 800 


Thr Pro 
        


