                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  DISPERSINS EXPRESSED WITH AMYLASE SIGNAL PEPTIDES

<130>  15066-WO-PCT

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AmyL signal peptide coding sequence

<400>  1
atgaaacaac aaaaacggct ttacgcccga ttgctgacgc tgttatttgc gctcatcttc       60

ttgctgcctc attctgcagc a                                                 81


<210>  2
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AmyL signal peptide

<400>  2

Met Lys Gln Gln Lys Arg Leu Tyr Ala Arg Leu Leu Thr Leu Leu Phe 
1               5                   10                  15      


Ala Leu Ile Phe Leu Leu Pro His Ser Ala Ala 
            20                  25          


<210>  3
<211>  1050
<212>  DNA
<213>  Terribacillus saccharophilus


<220>
<221>  CDS
<222>  (1)..(1047)

<220>
<221>  sig_peptide
<222>  (1)..(75)

<220>
<221>  mat_peptide
<222>  (76)..(1047)

<400>  3
atg ttg att aaa ttt ctt tct atc aca aca gtt agt ata ctc ttg ttt         48
Met Leu Ile Lys Phe Leu Ser Ile Thr Thr Val Ser Ile Leu Leu Phe           
-25                 -20                 -15                 -10           

cta acg atg gcg aat aca gca caa gca aag gat caa gag aaa gga att         96
Leu Thr Met Ala Asn Thr Ala Gln Ala Lys Asp Gln Glu Lys Gly Ile           
                -5              -1  1               5                     

aca atc gat att tcg aga aag tac tat tcc att ggt aca tta aaa gca        144
Thr Ile Asp Ile Ser Arg Lys Tyr Tyr Ser Ile Gly Thr Leu Lys Ala           
        10                  15                  20                        

att gtt gac gag ata aac gct aat ggc gga gac tac ttg cag ctg cat        192
Ile Val Asp Glu Ile Asn Ala Asn Gly Gly Asp Tyr Leu Gln Leu His           
    25                  30                  35                            

ttc tca gat aat gag agc tat gcg att gcc tct gaa ttc ctt ggt cag        240
Phe Ser Asp Asn Glu Ser Tyr Ala Ile Ala Ser Glu Phe Leu Gly Gln           
40                  45                  50                  55            

aac agt gaa aat cct aat tct act tac tta aca aaa aag gaa ctt tta        288
Asn Ser Glu Asn Pro Asn Ser Thr Tyr Leu Thr Lys Lys Glu Leu Leu           
                60                  65                  70                

tcg ctt ata gca tac agc aat gat aga aat ata atg gtt att cct gat        336
Ser Leu Ile Ala Tyr Ser Asn Asp Arg Asn Ile Met Val Ile Pro Asp           
            75                  80                  85                    

att gat tta cca gcg cat tcc aag ggc tgg ctg aat gta atg aaa gag        384
Ile Asp Leu Pro Ala His Ser Lys Gly Trp Leu Asn Val Met Lys Glu           
        90                  95                  100                       

aaa gat agt gga tta tat acg gac atc gta aca gat tat agt gaa gat        432
Lys Asp Ser Gly Leu Tyr Thr Asp Ile Val Thr Asp Tyr Ser Glu Asp           
    105                 110                 115                           

aca ttg gat tat cac aat aat gca gct gcc ctg tat aca gca aac cag        480
Thr Leu Asp Tyr His Asn Asn Ala Ala Ala Leu Tyr Thr Ala Asn Gln           
120                 125                 130                 135           

cta ttg gac gaa gta ctt gat tta ttt tat cag cct aag ttc gca gga        528
Leu Leu Asp Glu Val Leu Asp Leu Phe Tyr Gln Pro Lys Phe Ala Gly           
                140                 145                 150               

aaa cag agg atc gta ctt ggc ggg gat gaa gtg ccg ggg agt gga gca        576
Lys Gln Arg Ile Val Leu Gly Gly Asp Glu Val Pro Gly Ser Gly Ala           
            155                 160                 165                   

cat cag acg gat ttt atc cga ttt atg aat caa att gac gaa aca gct        624
His Gln Thr Asp Phe Ile Arg Phe Met Asn Gln Ile Asp Glu Thr Ala           
        170                 175                 180                       

aaa gcc agc aat tat gaa ccg cag atg tgg aat gac agt att aca cca        672
Lys Ala Ser Asn Tyr Glu Pro Gln Met Trp Asn Asp Ser Ile Thr Pro           
    185                 190                 195                           

gaa gga att caa aat ttg gat aga agt ttc tct atc ctt tat tgg aag        720
Glu Gly Ile Gln Asn Leu Asp Arg Ser Phe Ser Ile Leu Tyr Trp Lys           
200                 205                 210                 215           

caa agc aca ctc tca agc ggc gca cag ggt tta gat gta caa aat ttt        768
Gln Ser Thr Leu Ser Ser Gly Ala Gln Gly Leu Asp Val Gln Asn Phe           
                220                 225                 230               

gaa gaa aag ggt ttt tcg gta tat aac tat aat gcg tat tct tta tat        816
Glu Glu Lys Gly Phe Ser Val Tyr Asn Tyr Asn Ala Tyr Ser Leu Tyr           
            235                 240                 245                   

ttc ctg cca tca act cgg ttt aca caa gaa gat ata aca gaa cag att        864
Phe Leu Pro Ser Thr Arg Phe Thr Gln Glu Asp Ile Thr Glu Gln Ile           
        250                 255                 260                       

gac tat atg aaa tgg gct tac gca tat aat aag ttt ttc tac att tca        912
Asp Tyr Met Lys Trp Ala Tyr Ala Tyr Asn Lys Phe Phe Tyr Ile Ser           
    265                 270                 275                           

gat tac tac aaa caa gtg gat act tct aac gtg aaa gga tcc agc tta        960
Asp Tyr Tyr Lys Gln Val Asp Thr Ser Asn Val Lys Gly Ser Ser Leu           
280                 285                 290                 295           

gtt ttt tgg ggc gaa cac gcc aat gac tta agc caa gag gga ttg ctt       1008
Val Phe Trp Gly Glu His Ala Asn Asp Leu Ser Gln Glu Gly Leu Leu           
                300                 305                 310               

gaa caa gag aag cct tta ata caa aat ttt ctt agc tta taa               1050
Glu Gln Glu Lys Pro Leu Ile Gln Asn Phe Leu Ser Leu                       
            315                 320                                       


<210>  4
<211>  349
<212>  PRT
<213>  Terribacillus saccharophilus

<400>  4

Met Leu Ile Lys Phe Leu Ser Ile Thr Thr Val Ser Ile Leu Leu Phe 
-25                 -20                 -15                 -10 


Leu Thr Met Ala Asn Thr Ala Gln Ala Lys Asp Gln Glu Lys Gly Ile 
                -5              -1  1               5           


Thr Ile Asp Ile Ser Arg Lys Tyr Tyr Ser Ile Gly Thr Leu Lys Ala 
        10                  15                  20              


Ile Val Asp Glu Ile Asn Ala Asn Gly Gly Asp Tyr Leu Gln Leu His 
    25                  30                  35                  


Phe Ser Asp Asn Glu Ser Tyr Ala Ile Ala Ser Glu Phe Leu Gly Gln 
40                  45                  50                  55  


Asn Ser Glu Asn Pro Asn Ser Thr Tyr Leu Thr Lys Lys Glu Leu Leu 
                60                  65                  70      


Ser Leu Ile Ala Tyr Ser Asn Asp Arg Asn Ile Met Val Ile Pro Asp 
            75                  80                  85          


Ile Asp Leu Pro Ala His Ser Lys Gly Trp Leu Asn Val Met Lys Glu 
        90                  95                  100             


Lys Asp Ser Gly Leu Tyr Thr Asp Ile Val Thr Asp Tyr Ser Glu Asp 
    105                 110                 115                 


Thr Leu Asp Tyr His Asn Asn Ala Ala Ala Leu Tyr Thr Ala Asn Gln 
120                 125                 130                 135 


Leu Leu Asp Glu Val Leu Asp Leu Phe Tyr Gln Pro Lys Phe Ala Gly 
                140                 145                 150     


Lys Gln Arg Ile Val Leu Gly Gly Asp Glu Val Pro Gly Ser Gly Ala 
            155                 160                 165         


His Gln Thr Asp Phe Ile Arg Phe Met Asn Gln Ile Asp Glu Thr Ala 
        170                 175                 180             


Lys Ala Ser Asn Tyr Glu Pro Gln Met Trp Asn Asp Ser Ile Thr Pro 
    185                 190                 195                 


Glu Gly Ile Gln Asn Leu Asp Arg Ser Phe Ser Ile Leu Tyr Trp Lys 
200                 205                 210                 215 


Gln Ser Thr Leu Ser Ser Gly Ala Gln Gly Leu Asp Val Gln Asn Phe 
                220                 225                 230     


Glu Glu Lys Gly Phe Ser Val Tyr Asn Tyr Asn Ala Tyr Ser Leu Tyr 
            235                 240                 245         


Phe Leu Pro Ser Thr Arg Phe Thr Gln Glu Asp Ile Thr Glu Gln Ile 
        250                 255                 260             


Asp Tyr Met Lys Trp Ala Tyr Ala Tyr Asn Lys Phe Phe Tyr Ile Ser 
    265                 270                 275                 


Asp Tyr Tyr Lys Gln Val Asp Thr Ser Asn Val Lys Gly Ser Ser Leu 
280                 285                 290                 295 


Val Phe Trp Gly Glu His Ala Asn Asp Leu Ser Gln Glu Gly Leu Leu 
                300                 305                 310     


Glu Gln Glu Lys Pro Leu Ile Gln Asn Phe Leu Ser Leu 
            315                 320                 


<210>  5
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPamyLDisp43syn coding sequence


<220>
<221>  CDS
<222>  (1)..(1059)

<220>
<221>  sig_peptide
<222>  (1)..(84)

<220>
<221>  mat_peptide
<222>  (85)..(1059)

<400>  5
atg aaa caa caa aaa cgg ctt tac gcc cga ttg ctg acg ctg tta ttt         48
Met Lys Gln Gln Lys Arg Leu Tyr Ala Arg Leu Leu Thr Leu Leu Phe           
            -25                 -20                 -15                   

gcg ctc atc ttc ttg ctg cct cat tct gca gca gcg gcg aaa gat caa         96
Ala Leu Ile Phe Leu Leu Pro His Ser Ala Ala Ala Ala Lys Asp Gln           
        -10                 -5              -1  1                         

gaa aaa ggc atc acg atc gat atc agc cgc aaa tat tac agc atc ggc        144
Glu Lys Gly Ile Thr Ile Asp Ile Ser Arg Lys Tyr Tyr Ser Ile Gly           
5                   10                  15                  20            

acg ctg aaa gcg atc gtc gat gaa atc aac gcg aat ggc gga gat tat        192
Thr Leu Lys Ala Ile Val Asp Glu Ile Asn Ala Asn Gly Gly Asp Tyr           
                25                  30                  35                

ctg caa ctg cat ttt agc gat aac gaa agc tat gcg atc gcg agc gaa        240
Leu Gln Leu His Phe Ser Asp Asn Glu Ser Tyr Ala Ile Ala Ser Glu           
            40                  45                  50                    

ttt ctg ggc caa aac agc gaa aac ccg aac agc acg tat ctg acg aaa        288
Phe Leu Gly Gln Asn Ser Glu Asn Pro Asn Ser Thr Tyr Leu Thr Lys           
        55                  60                  65                        

aaa gaa ctg ctg agc ctg atc gcg tat agc aac gat cgc aac atc atg        336
Lys Glu Leu Leu Ser Leu Ile Ala Tyr Ser Asn Asp Arg Asn Ile Met           
    70                  75                  80                            

gtc atc ccg gac atc gat ctt ccg gca cat agc aaa ggc tgg ctg aac        384
Val Ile Pro Asp Ile Asp Leu Pro Ala His Ser Lys Gly Trp Leu Asn           
85                  90                  95                  100           

gtc atg aaa gaa aaa gat agc gga ctg tat acg gat atc gtc acg gat        432
Val Met Lys Glu Lys Asp Ser Gly Leu Tyr Thr Asp Ile Val Thr Asp           
                105                 110                 115               

tat agc gaa gat acg ctg gac tat cat aac aat gcg gca gcg ctt tat        480
Tyr Ser Glu Asp Thr Leu Asp Tyr His Asn Asn Ala Ala Ala Leu Tyr           
            120                 125                 130                   

acg gcg aac caa ctg ctg gat gaa gtc ctg gac ctg ttt tat caa ccg        528
Thr Ala Asn Gln Leu Leu Asp Glu Val Leu Asp Leu Phe Tyr Gln Pro           
        135                 140                 145                       

aaa ttt gcg gga aaa caa cgc atc gtc ctt gga ggc gac gaa gtc cct        576
Lys Phe Ala Gly Lys Gln Arg Ile Val Leu Gly Gly Asp Glu Val Pro           
    150                 155                 160                           

ggc agc gga gcg cat caa acg gat ttt atc cgc ttt atg aac cag atc        624
Gly Ser Gly Ala His Gln Thr Asp Phe Ile Arg Phe Met Asn Gln Ile           
165                 170                 175                 180           

gat gaa acg gcg aaa gcg agc aac tat gaa ccg caa atg tgg aat gat        672
Asp Glu Thr Ala Lys Ala Ser Asn Tyr Glu Pro Gln Met Trp Asn Asp           
                185                 190                 195               

agc atc aca ccg gaa ggc atc caa aac ctg gat cgc agc ttt agc atc        720
Ser Ile Thr Pro Glu Gly Ile Gln Asn Leu Asp Arg Ser Phe Ser Ile           
            200                 205                 210                   

ctg tat tgg aaa caa agc acg ctg tca agc gga gcc caa ggc ctg gat        768
Leu Tyr Trp Lys Gln Ser Thr Leu Ser Ser Gly Ala Gln Gly Leu Asp           
        215                 220                 225                       

gtc caa aac ttt gaa gaa aag ggc ttt agc gtc tat aac tat aat gcg        816
Val Gln Asn Phe Glu Glu Lys Gly Phe Ser Val Tyr Asn Tyr Asn Ala           
    230                 235                 240                           

tac agc ctg tac ttt ctg ccg agc acg cgc ttt acg caa gaa gat atc        864
Tyr Ser Leu Tyr Phe Leu Pro Ser Thr Arg Phe Thr Gln Glu Asp Ile           
245                 250                 255                 260           

acg gaa caa atc gac tat atg aaa tgg gcg tat gcg tac aac aag ttc        912
Thr Glu Gln Ile Asp Tyr Met Lys Trp Ala Tyr Ala Tyr Asn Lys Phe           
                265                 270                 275               

ttt tat atc agc gac tac tac aaa cag gtc gat acg agc aac gtc aaa        960
Phe Tyr Ile Ser Asp Tyr Tyr Lys Gln Val Asp Thr Ser Asn Val Lys           
            280                 285                 290                   

ggc agc agc ctg gtc ttt tgg gga gaa cat gcg aac gat ctg agc caa       1008
Gly Ser Ser Leu Val Phe Trp Gly Glu His Ala Asn Asp Leu Ser Gln           
        295                 300                 305                       

gaa ggc ctg ctg gaa caa gaa aaa ccg ctg atc caa aat ttt ctg agc       1056
Glu Gly Leu Leu Glu Gln Glu Lys Pro Leu Ile Gln Asn Phe Leu Ser           
    310                 315                 320                           

ctg taa                                                               1062
Leu                                                                       
325                                                                       


<210>  6
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Lys Gln Gln Lys Arg Leu Tyr Ala Arg Leu Leu Thr Leu Leu Phe 
            -25                 -20                 -15         


Ala Leu Ile Phe Leu Leu Pro His Ser Ala Ala Ala Ala Lys Asp Gln 
        -10                 -5              -1  1               


Glu Lys Gly Ile Thr Ile Asp Ile Ser Arg Lys Tyr Tyr Ser Ile Gly 
5                   10                  15                  20  


Thr Leu Lys Ala Ile Val Asp Glu Ile Asn Ala Asn Gly Gly Asp Tyr 
                25                  30                  35      


Leu Gln Leu His Phe Ser Asp Asn Glu Ser Tyr Ala Ile Ala Ser Glu 
            40                  45                  50          


Phe Leu Gly Gln Asn Ser Glu Asn Pro Asn Ser Thr Tyr Leu Thr Lys 
        55                  60                  65              


Lys Glu Leu Leu Ser Leu Ile Ala Tyr Ser Asn Asp Arg Asn Ile Met 
    70                  75                  80                  


Val Ile Pro Asp Ile Asp Leu Pro Ala His Ser Lys Gly Trp Leu Asn 
85                  90                  95                  100 


Val Met Lys Glu Lys Asp Ser Gly Leu Tyr Thr Asp Ile Val Thr Asp 
                105                 110                 115     


Tyr Ser Glu Asp Thr Leu Asp Tyr His Asn Asn Ala Ala Ala Leu Tyr 
            120                 125                 130         


Thr Ala Asn Gln Leu Leu Asp Glu Val Leu Asp Leu Phe Tyr Gln Pro 
        135                 140                 145             


Lys Phe Ala Gly Lys Gln Arg Ile Val Leu Gly Gly Asp Glu Val Pro 
    150                 155                 160                 


Gly Ser Gly Ala His Gln Thr Asp Phe Ile Arg Phe Met Asn Gln Ile 
165                 170                 175                 180 


Asp Glu Thr Ala Lys Ala Ser Asn Tyr Glu Pro Gln Met Trp Asn Asp 
                185                 190                 195     


Ser Ile Thr Pro Glu Gly Ile Gln Asn Leu Asp Arg Ser Phe Ser Ile 
            200                 205                 210         


Leu Tyr Trp Lys Gln Ser Thr Leu Ser Ser Gly Ala Gln Gly Leu Asp 
        215                 220                 225             


Val Gln Asn Phe Glu Glu Lys Gly Phe Ser Val Tyr Asn Tyr Asn Ala 
    230                 235                 240                 


Tyr Ser Leu Tyr Phe Leu Pro Ser Thr Arg Phe Thr Gln Glu Asp Ile 
245                 250                 255                 260 


Thr Glu Gln Ile Asp Tyr Met Lys Trp Ala Tyr Ala Tyr Asn Lys Phe 
                265                 270                 275     


Phe Tyr Ile Ser Asp Tyr Tyr Lys Gln Val Asp Thr Ser Asn Val Lys 
            280                 285                 290         


Gly Ser Ser Leu Val Phe Trp Gly Glu His Ala Asn Asp Leu Ser Gln 
        295                 300                 305             


Glu Gly Leu Leu Glu Gln Glu Lys Pro Leu Ile Gln Asn Phe Leu Ser 
    310                 315                 320                 


Leu 
325 


<210>  7
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPaprHDisp45 coding sequence


<220>
<221>  CDS
<222>  (1)..(1053)

<220>
<221>  sig_peptide
<222>  (1)..(81)

<220>
<221>  mat_peptide
<222>  (82)..(1053)

<400>  7
atg aag aaa ccg ttg ggg aaa att gtc gca agc acc gca cta ctc att         48
Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile           
        -25                 -20                 -15                       

tct gtt gct ttt agt tca tcg ata gca tcg gct cag gac cag gag aag         96
Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Gln Asp Gln Glu Lys           
    -10                 -5              -1  1               5             

ggc atc acg atc gac atc tca cgc aag cac tac acg gtt gag acg ctt        144
Gly Ile Thr Ile Asp Ile Ser Arg Lys His Tyr Thr Val Glu Thr Leu           
                10                  15                  20                

aag tca ctt gtt gac gag atc tca tac aat ggt ggc aac tac gtt cag        192
Lys Ser Leu Val Asp Glu Ile Ser Tyr Asn Gly Gly Asn Tyr Val Gln           
            25                  30                  35                    

ctt cac ttc tct gac aac gag aac tac gcg atc gcg tca gag tac ctt        240
Leu His Phe Ser Asp Asn Glu Asn Tyr Ala Ile Ala Ser Glu Tyr Leu           
        40                  45                  50                        

ggc caa tca tct gag aac acg aac aac acg tac ctt acg aag aac gag        288
Gly Gln Ser Ser Glu Asn Thr Asn Asn Thr Tyr Leu Thr Lys Asn Glu           
    55                  60                  65                            

ctt ctt tca ctt atc gcg tac tct aac gac aag gac atc ctt gtt atc        336
Leu Leu Ser Leu Ile Ala Tyr Ser Asn Asp Lys Asp Ile Leu Val Ile           
70                  75                  80                  85            

cct gac atc gac ctt cct gcg cac tct aag ggc tgg ctt gag ctt atc        384
Pro Asp Ile Asp Leu Pro Ala His Ser Lys Gly Trp Leu Glu Leu Ile           
                90                  95                  100               

aag aag aag gac gtt aaa ctt tac aac gac atc gtt acg gac tac agc        432
Lys Lys Lys Asp Val Lys Leu Tyr Asn Asp Ile Val Thr Asp Tyr Ser           
            105                 110                 115                   

gag gag acg ctt gac tac tac gac aac cgc gta gcg tta gac acg gtt        480
Glu Glu Thr Leu Asp Tyr Tyr Asp Asn Arg Val Ala Leu Asp Thr Val           
        120                 125                 130                       

aac caa ctt ctt gac gag gtt ctt gac ctt ttc tac cag cct aag ttc        528
Asn Gln Leu Leu Asp Glu Val Leu Asp Leu Phe Tyr Gln Pro Lys Phe           
    135                 140                 145                           

gag ggc aag cag cgc atc gta ctt ggt ggc gac gag gtt tca ggc agc        576
Glu Gly Lys Gln Arg Ile Val Leu Gly Gly Asp Glu Val Ser Gly Ser           
150                 155                 160                 165           

gag gtt cac caa ctt gac ttc atc gac ttc atg aac cag atc gcg tct        624
Glu Val His Gln Leu Asp Phe Ile Asp Phe Met Asn Gln Ile Ala Ser           
                170                 175                 180               

acg gtt aag gag agc aag tac gag cca caa atg tgg aac gac agc atc        672
Thr Val Lys Glu Ser Lys Tyr Glu Pro Gln Met Trp Asn Asp Ser Ile           
            185                 190                 195                   

acg tct gag ggc atc gcg aac ctt gac gac tct ttc tct atc ctt tac        720
Thr Ser Glu Gly Ile Ala Asn Leu Asp Asp Ser Phe Ser Ile Leu Tyr           
        200                 205                 210                       

tgg cag cag tct acg ctt tct tct ggc gag gag tca ctt aac gtt gag        768
Trp Gln Gln Ser Thr Leu Ser Ser Gly Glu Glu Ser Leu Asn Val Glu           
    215                 220                 225                           

gac ttc gag aac tgg ggc ttc tct gtt tac aac tac aat gcg tac agc        816
Asp Phe Glu Asn Trp Gly Phe Ser Val Tyr Asn Tyr Asn Ala Tyr Ser           
230                 235                 240                 245           

ctt tac ttc ctt cct tct aac ggc ttc acg cag gag gac atc aac gag        864
Leu Tyr Phe Leu Pro Ser Asn Gly Phe Thr Gln Glu Asp Ile Asn Glu           
                250                 255                 260               

cag atg gac tac atg aac tgg gcg tac gcg cac aac aag ttc ttc tac        912
Gln Met Asp Tyr Met Asn Trp Ala Tyr Ala His Asn Lys Phe Phe Tyr           
            265                 270                 275                   

atc tct gac tac tac cac gcg gta gag acg tca aac gtt aag ggc agc        960
Ile Ser Asp Tyr Tyr His Ala Val Glu Thr Ser Asn Val Lys Gly Ser           
        280                 285                 290                       

tca ctt acg ttc tgg ggt gag cac gcg acg gac ctt tca cag aag aaa       1008
Ser Leu Thr Phe Trp Gly Glu His Ala Thr Asp Leu Ser Gln Lys Lys           
    295                 300                 305                           

ctt ctt aag cag gag ctt cct ctt atc cgc cac tac ctt aac ctt taa       1056
Leu Leu Lys Gln Glu Leu Pro Leu Ile Arg His Tyr Leu Asn Leu               
310                 315                 320                               


<210>  8
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
        -25                 -20                 -15             


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Gln Asp Gln Glu Lys 
    -10                 -5              -1  1               5   


Gly Ile Thr Ile Asp Ile Ser Arg Lys His Tyr Thr Val Glu Thr Leu 
                10                  15                  20      


Lys Ser Leu Val Asp Glu Ile Ser Tyr Asn Gly Gly Asn Tyr Val Gln 
            25                  30                  35          


Leu His Phe Ser Asp Asn Glu Asn Tyr Ala Ile Ala Ser Glu Tyr Leu 
        40                  45                  50              


Gly Gln Ser Ser Glu Asn Thr Asn Asn Thr Tyr Leu Thr Lys Asn Glu 
    55                  60                  65                  


Leu Leu Ser Leu Ile Ala Tyr Ser Asn Asp Lys Asp Ile Leu Val Ile 
70                  75                  80                  85  


Pro Asp Ile Asp Leu Pro Ala His Ser Lys Gly Trp Leu Glu Leu Ile 
                90                  95                  100     


Lys Lys Lys Asp Val Lys Leu Tyr Asn Asp Ile Val Thr Asp Tyr Ser 
            105                 110                 115         


Glu Glu Thr Leu Asp Tyr Tyr Asp Asn Arg Val Ala Leu Asp Thr Val 
        120                 125                 130             


Asn Gln Leu Leu Asp Glu Val Leu Asp Leu Phe Tyr Gln Pro Lys Phe 
    135                 140                 145                 


Glu Gly Lys Gln Arg Ile Val Leu Gly Gly Asp Glu Val Ser Gly Ser 
150                 155                 160                 165 


Glu Val His Gln Leu Asp Phe Ile Asp Phe Met Asn Gln Ile Ala Ser 
                170                 175                 180     


Thr Val Lys Glu Ser Lys Tyr Glu Pro Gln Met Trp Asn Asp Ser Ile 
            185                 190                 195         


Thr Ser Glu Gly Ile Ala Asn Leu Asp Asp Ser Phe Ser Ile Leu Tyr 
        200                 205                 210             


Trp Gln Gln Ser Thr Leu Ser Ser Gly Glu Glu Ser Leu Asn Val Glu 
    215                 220                 225                 


Asp Phe Glu Asn Trp Gly Phe Ser Val Tyr Asn Tyr Asn Ala Tyr Ser 
230                 235                 240                 245 


Leu Tyr Phe Leu Pro Ser Asn Gly Phe Thr Gln Glu Asp Ile Asn Glu 
                250                 255                 260     


Gln Met Asp Tyr Met Asn Trp Ala Tyr Ala His Asn Lys Phe Phe Tyr 
            265                 270                 275         


Ile Ser Asp Tyr Tyr His Ala Val Glu Thr Ser Asn Val Lys Gly Ser 
        280                 285                 290             


Ser Leu Thr Phe Trp Gly Glu His Ala Thr Asp Leu Ser Gln Lys Lys 
    295                 300                 305                 


Leu Leu Lys Gln Glu Leu Pro Leu Ile Arg His Tyr Leu Asn Leu 
310                 315                 320                 


<210>  9
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPamyLDisp45syn coding sequence


<220>
<221>  CDS
<222>  (1)..(1059)

<220>
<221>  sig_peptide
<222>  (1)..(84)

<220>
<221>  mat_peptide
<222>  (85)..(1059)

<400>  9
atg aaa caa caa aaa cgg ctt tac gcc cga ttg ctg acg ctg tta ttt         48
Met Lys Gln Gln Lys Arg Leu Tyr Ala Arg Leu Leu Thr Leu Leu Phe           
            -25                 -20                 -15                   

gcg ctc atc ttc ttg ctg cct cat tct gca gca gcg gcg cag gac cag         96
Ala Leu Ile Phe Leu Leu Pro His Ser Ala Ala Ala Ala Gln Asp Gln           
        -10                 -5              -1  1                         

gag aag ggc atc acg atc gac atc tca cgc aag cac tac acg gtt gag        144
Glu Lys Gly Ile Thr Ile Asp Ile Ser Arg Lys His Tyr Thr Val Glu           
5                   10                  15                  20            

acg ctt aag tca ctt gtt gac gag atc tca tac aat ggt ggc aac tac        192
Thr Leu Lys Ser Leu Val Asp Glu Ile Ser Tyr Asn Gly Gly Asn Tyr           
                25                  30                  35                

gtt cag ctt cac ttc tct gac aac gag aac tac gcg atc gcg tca gag        240
Val Gln Leu His Phe Ser Asp Asn Glu Asn Tyr Ala Ile Ala Ser Glu           
            40                  45                  50                    

tac ctt ggc caa tca tct gag aac acg aac aac acg tac ctt acg aag        288
Tyr Leu Gly Gln Ser Ser Glu Asn Thr Asn Asn Thr Tyr Leu Thr Lys           
        55                  60                  65                        

aac gag ctt ctt tca ctt atc gcg tac tct aac gac aag gac atc ctt        336
Asn Glu Leu Leu Ser Leu Ile Ala Tyr Ser Asn Asp Lys Asp Ile Leu           
    70                  75                  80                            

gtt atc cct gac atc gac ctt cct gcg cac tct aag ggc tgg ctt gag        384
Val Ile Pro Asp Ile Asp Leu Pro Ala His Ser Lys Gly Trp Leu Glu           
85                  90                  95                  100           

ctt atc aag aag aag gac gtt aaa ctt tac aac gac atc gtt acg gac        432
Leu Ile Lys Lys Lys Asp Val Lys Leu Tyr Asn Asp Ile Val Thr Asp           
                105                 110                 115               

tac agc gag gag acg ctt gac tac tac gac aac cgc gta gcg tta gac        480
Tyr Ser Glu Glu Thr Leu Asp Tyr Tyr Asp Asn Arg Val Ala Leu Asp           
            120                 125                 130                   

acg gtt aac caa ctt ctt gac gag gtt ctt gac ctt ttc tac cag cct        528
Thr Val Asn Gln Leu Leu Asp Glu Val Leu Asp Leu Phe Tyr Gln Pro           
        135                 140                 145                       

aag ttc gag ggc aag cag cgc atc gta ctt ggt ggc gac gag gtt tca        576
Lys Phe Glu Gly Lys Gln Arg Ile Val Leu Gly Gly Asp Glu Val Ser           
    150                 155                 160                           

ggc agc gag gtt cac caa ctt gac ttc atc gac ttc atg aac cag atc        624
Gly Ser Glu Val His Gln Leu Asp Phe Ile Asp Phe Met Asn Gln Ile           
165                 170                 175                 180           

gcg tct acg gtt aag gag agc aag tac gag cca caa atg tgg aac gac        672
Ala Ser Thr Val Lys Glu Ser Lys Tyr Glu Pro Gln Met Trp Asn Asp           
                185                 190                 195               

agc atc acg tct gag ggc atc gcg aac ctt gac gac tct ttc tct atc        720
Ser Ile Thr Ser Glu Gly Ile Ala Asn Leu Asp Asp Ser Phe Ser Ile           
            200                 205                 210                   

ctt tac tgg cag cag tct acg ctt tct tct ggc gag gag tca ctt aac        768
Leu Tyr Trp Gln Gln Ser Thr Leu Ser Ser Gly Glu Glu Ser Leu Asn           
        215                 220                 225                       

gtt gag gac ttc gag aac tgg ggc ttc tct gtt tac aac tac aat gcg        816
Val Glu Asp Phe Glu Asn Trp Gly Phe Ser Val Tyr Asn Tyr Asn Ala           
    230                 235                 240                           

tac agc ctt tac ttc ctt cct tct aac ggc ttc acg cag gag gac atc        864
Tyr Ser Leu Tyr Phe Leu Pro Ser Asn Gly Phe Thr Gln Glu Asp Ile           
245                 250                 255                 260           

aac gag cag atg gac tac atg aac tgg gcg tac gcg cac aac aag ttc        912
Asn Glu Gln Met Asp Tyr Met Asn Trp Ala Tyr Ala His Asn Lys Phe           
                265                 270                 275               

ttc tac atc tct gac tac tac cac gcg gta gag acg tca aac gtt aag        960
Phe Tyr Ile Ser Asp Tyr Tyr His Ala Val Glu Thr Ser Asn Val Lys           
            280                 285                 290                   

ggc agc tca ctt acg ttc tgg ggt gag cac gcg acg gac ctt tca cag       1008
Gly Ser Ser Leu Thr Phe Trp Gly Glu His Ala Thr Asp Leu Ser Gln           
        295                 300                 305                       

aag aaa ctt ctt aag cag gag ctt cct ctt atc cgc cac tac ctt aac       1056
Lys Lys Leu Leu Lys Gln Glu Leu Pro Leu Ile Arg His Tyr Leu Asn           
    310                 315                 320                           

ctt taa                                                               1062
Leu                                                                       
325                                                                       


<210>  10
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Lys Gln Gln Lys Arg Leu Tyr Ala Arg Leu Leu Thr Leu Leu Phe 
            -25                 -20                 -15         


Ala Leu Ile Phe Leu Leu Pro His Ser Ala Ala Ala Ala Gln Asp Gln 
        -10                 -5              -1  1               


Glu Lys Gly Ile Thr Ile Asp Ile Ser Arg Lys His Tyr Thr Val Glu 
5                   10                  15                  20  


Thr Leu Lys Ser Leu Val Asp Glu Ile Ser Tyr Asn Gly Gly Asn Tyr 
                25                  30                  35      


Val Gln Leu His Phe Ser Asp Asn Glu Asn Tyr Ala Ile Ala Ser Glu 
            40                  45                  50          


Tyr Leu Gly Gln Ser Ser Glu Asn Thr Asn Asn Thr Tyr Leu Thr Lys 
        55                  60                  65              


Asn Glu Leu Leu Ser Leu Ile Ala Tyr Ser Asn Asp Lys Asp Ile Leu 
    70                  75                  80                  


Val Ile Pro Asp Ile Asp Leu Pro Ala His Ser Lys Gly Trp Leu Glu 
85                  90                  95                  100 


Leu Ile Lys Lys Lys Asp Val Lys Leu Tyr Asn Asp Ile Val Thr Asp 
                105                 110                 115     


Tyr Ser Glu Glu Thr Leu Asp Tyr Tyr Asp Asn Arg Val Ala Leu Asp 
            120                 125                 130         


Thr Val Asn Gln Leu Leu Asp Glu Val Leu Asp Leu Phe Tyr Gln Pro 
        135                 140                 145             


Lys Phe Glu Gly Lys Gln Arg Ile Val Leu Gly Gly Asp Glu Val Ser 
    150                 155                 160                 


Gly Ser Glu Val His Gln Leu Asp Phe Ile Asp Phe Met Asn Gln Ile 
165                 170                 175                 180 


Ala Ser Thr Val Lys Glu Ser Lys Tyr Glu Pro Gln Met Trp Asn Asp 
                185                 190                 195     


Ser Ile Thr Ser Glu Gly Ile Ala Asn Leu Asp Asp Ser Phe Ser Ile 
            200                 205                 210         


Leu Tyr Trp Gln Gln Ser Thr Leu Ser Ser Gly Glu Glu Ser Leu Asn 
        215                 220                 225             


Val Glu Asp Phe Glu Asn Trp Gly Phe Ser Val Tyr Asn Tyr Asn Ala 
    230                 235                 240                 


Tyr Ser Leu Tyr Phe Leu Pro Ser Asn Gly Phe Thr Gln Glu Asp Ile 
245                 250                 255                 260 


Asn Glu Gln Met Asp Tyr Met Asn Trp Ala Tyr Ala His Asn Lys Phe 
                265                 270                 275     


Phe Tyr Ile Ser Asp Tyr Tyr His Ala Val Glu Thr Ser Asn Val Lys 
            280                 285                 290         


Gly Ser Ser Leu Thr Phe Trp Gly Glu His Ala Thr Asp Leu Ser Gln 
        295                 300                 305             


Lys Lys Leu Leu Lys Gln Glu Leu Pro Leu Ile Arg His Tyr Leu Asn 
    310                 315                 320                 


Leu 
325 


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = V (Val) or I (Ile) or M (Met)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = L (Leu) or I (Ile) or V (Val)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = G (Gly) or A (Ala) or V (Val)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = V (Val) or I (Ile)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = P (Pro) or S (Ser) or A (Ala)

<400>  11

Xaa Xaa Gly Xaa Asp Glu Xaa Xaa 
1               5               


