                         SEQUENCE LISTING

<110>  Hutchison Medipharma Limited
 
<120>  Pyrimidone compounds and their uses

<130>  PF 210573PCT

<160>  1     

<170>  PatentIn version 3.3

<210>  1
<211>  618
<212>  PRT
<213>  Artificial

<220>
<223>  Construct

<400>  1

Met His His His His His His His His His His Ser Pro Ile Leu Gly 
1               5                   10                  15      


Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro Thr Arg Leu Leu Leu Glu 
            20                  25                  30          


Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu Tyr Glu Arg Asp Glu Gly 
        35                  40                  45              


Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu Gly Leu Glu Phe Pro Asn 
    50                  55                  60                  


Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys Leu Thr Gln Ser Met Ala 
65                  70                  75                  80  


Ile Ile Arg Tyr Ile Ala Asp Lys His Asn Met Leu Gly Gly Cys Pro 
                85                  90                  95      


Lys Glu Arg Ala Glu Ile Ser Met Leu Glu Gly Ala Val Leu Asp Ile 
            100                 105                 110         


Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser Lys Asp Phe Glu Thr Leu 
        115                 120                 125             


Lys Val Asp Phe Leu Ser Lys Leu Pro Glu Met Leu Lys Met Phe Glu 
    130                 135                 140                 


Asp Arg Leu Cys His Lys Thr Tyr Leu Asn Gly Asp His Val Thr His 
145                 150                 155                 160 


Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp Val Val Leu Tyr Met Asp 
                165                 170                 175     


Pro Met Cys Leu Asp Ala Phe Pro Lys Leu Val Cys Phe Lys Lys Arg 
            180                 185                 190         


Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr Leu Lys Ser Ser Lys Tyr 
        195                 200                 205             


Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala Thr Phe Gly Gly Gly Asp 
    210                 215                 220                 


His Pro Pro Lys Ser Asp Leu Val Pro Arg Gly Ser Glu Asn Leu Tyr 
225                 230                 235                 240 


Phe Gln Gly Met Gln Pro Asp Met Ser Leu Asn Val Ile Lys Met Lys 
                245                 250                 255     


Ser Ser Asp Phe Leu Glu Ser Ala Glu Leu Asp Ser Gly Gly Phe Gly 
            260                 265                 270         


Lys Val Ser Leu Cys Phe His Arg Thr Gln Gly Leu Met Ile Met Lys 
        275                 280                 285             


Thr Val Tyr Lys Gly Pro Asn Cys Ile Glu His Asn Glu Ala Leu Leu 
    290                 295                 300                 


Glu Glu Ala Lys Met Met Asn Arg Leu Arg His Ser Arg Val Val Lys 
305                 310                 315                 320 


Leu Leu Gly Val Ile Ile Glu Glu Gly Lys Tyr Ser Leu Val Met Glu 
                325                 330                 335     


Tyr Met Glu Lys Gly Asn Leu Met His Val Leu Lys Ala Glu Met Ser 
            340                 345                 350         


Thr Pro Leu Ser Val Lys Gly Arg Ile Ile Leu Glu Ile Ile Glu Gly 
        355                 360                 365             


Met Cys Tyr Leu His Gly Lys Gly Val Ile His Lys Asp Leu Lys Pro 
    370                 375                 380                 


Glu Asn Ile Leu Val Asp Asn Asp Phe His Ile Lys Ile Ala Asp Leu 
385                 390                 395                 400 


Gly Leu Ala Ser Phe Lys Met Trp Ser Lys Leu Asn Asn Glu Glu His 
                405                 410                 415     


Asn Glu Leu Arg Glu Val Asp Gly Thr Ala Lys Lys Asn Gly Gly Thr 
            420                 425                 430         


Leu Tyr Tyr Met Ala Pro Glu His Leu Asn Asp Val Asn Ala Lys Pro 
        435                 440                 445             


Thr Glu Lys Ser Asp Val Tyr Ser Phe Ala Val Val Leu Trp Ala Ile 
    450                 455                 460                 


Phe Ala Asn Lys Glu Pro Tyr Glu Asn Ala Ile Cys Glu Gln Gln Leu 
465                 470                 475                 480 


Ile Met Cys Ile Lys Ser Gly Asn Arg Pro Asp Val Asp Asp Ile Thr 
                485                 490                 495     


Glu Tyr Cys Pro Arg Glu Ile Ile Ser Leu Met Lys Leu Cys Trp Glu 
            500                 505                 510         


Ala Asn Pro Glu Ala Arg Pro Thr Phe Pro Gly Ile Glu Glu Lys Phe 
        515                 520                 525             


Arg Pro Phe Tyr Leu Ser Gln Leu Glu Glu Ser Val Glu Glu Asp Val 
    530                 535                 540                 


Lys Ser Leu Lys Lys Glu Tyr Ser Asn Glu Asn Ala Val Val Lys Arg 
545                 550                 555                 560 


Met Gln Ser Leu Gln Leu Asp Cys Val Ala Val Pro Ser Ser Arg Ser 
                565                 570                 575     


Asn Ser Ala Thr Glu Gln Pro Gly Ser Leu His Ser Ser Gln Gly Leu 
            580                 585                 590         


Gly Met Gly Pro Val Glu Glu Ser Trp Phe Ala Pro Ser Leu Glu His 
        595                 600                 605             


Pro Gln Glu Glu Asn Glu Pro Ser Leu Gln 
    610                 615             


