                         SEQUENCE LISTING

<110>  Nanjing Legend Biotech Co., Ltd.
 
<120>  Engineered immunoresponsive cells and uses thereof

<130>  P10885-PCT

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A element

<400>  1

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  2
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnTGFRII armor

<400>  2

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser 
        195                 


<210>  3
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-/IL-7 ICR, TGFRII fused to IL-7R, TGFRI fused to c

<400>  3

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser 
                165                 170                 175     


Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys 
            180                 185                 190         


Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys 
        195                 200                 205             


Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser 
    210                 215                 220                 


Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp 
225                 230                 235                 240 


Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
                245                 250                 255     


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
            260                 265                 270         


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe 
        275                 280                 285             


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
    290                 295                 300                 


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
305                 310                 315                 320 


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
                325                 330                 335     


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
            340                 345                 350         


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
        355                 360                 365             


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
    370                 375                 380                 


Asn Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
385                 390                 395                 400 


Asp Val Glu Glu Asn Pro Gly Pro Met Glu Ala Ala Val Ala Ala Pro 
                405                 410                 415     


Arg Pro Arg Leu Leu Leu Leu Val Leu Ala Ala Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
        435                 440                 445             


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
    450                 455                 460                 


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
465                 470                 475                 480 


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
                485                 490                 495     


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
            500                 505                 510         


His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Lys Ser Ser Pro Gly 
        515                 520                 525             


Leu Gly Pro Val Glu Leu Val Val Ile Ser Val Gly Ser Met Gly Leu 
    530                 535                 540                 


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
545                 550                 555                 560 


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
                565                 570                 575     


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
            580                 585                 590         


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
        595                 600                 605             


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
    610                 615                 620                 


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
625                 630                 635                 640 


Thr 
    


<210>  4
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-/IL-7 ICR, TGFRII fused to c, TGFRI fused to IL-7R

<400>  4

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Val Ile Ser Val Gly Ser Met Gly Leu 
                165                 170                 175     


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
            180                 185                 190         


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
        195                 200                 205             


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
    210                 215                 220                 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
225                 230                 235                 240 


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
                245                 250                 255     


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
            260                 265                 270         


Thr Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        275                 280                 285             


Val Glu Glu Asn Pro Gly Pro Met Glu Ala Ala Val Ala Ala Pro Arg 
    290                 295                 300                 


Pro Arg Leu Leu Leu Leu Val Leu Ala Ala Ala Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu Cys 
                325                 330                 335     


Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val Ser 
            340                 345                 350         


Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile Ala 
        355                 360                 365             


Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro Ser 
    370                 375                 380                 


Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp His 
385                 390                 395                 400 


Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Lys Ser Ser Pro Gly Leu 
                405                 410                 415     


Gly Pro Val Glu Leu Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe 
            420                 425                 430         


Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys 
        435                 440                 445             


Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr 
    450                 455                 460                 


Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe 
465                 470                 475                 480 


Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile 
                485                 490                 495     


Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln 
            500                 505                 510         


Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser 
        515                 520                 525             


Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly 
    530                 535                 540                 


Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp 
545                 550                 555                 560 


Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly 
                565                 570                 575     


Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr 
            580                 585                 590         


Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu 
        595                 600                 605             


Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly 
    610                 615                 620                 


Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
625                 630                 635                 640 


Gln 
    


<210>  5
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-/IL-12 ICR, TGFRII fused to IL-12R2, TGFRI fused to 
       IL-12R1

<400>  5

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Trp Met Ala Phe Val Ala Pro Ser Ile Cys 
                165                 170                 175     


Ile Ala Ile Ile Met Val Gly Ile Phe Ser Thr His Tyr Phe Gln Gln 
            180                 185                 190         


Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro Gln Trp Cys Ser Arg 
        195                 200                 205             


Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys Tyr Pro Ile 
    210                 215                 220                 


Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu Ile Asp Trp 
225                 230                 235                 240 


Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile Ser Glu Val Leu His 
                245                 250                 255     


Gln Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp Pro Gln 
            260                 265                 270         


Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp Met Met 
        275                 280                 285             


His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala Glu Ser 
    290                 295                 300                 


Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly Ser Asp 
305                 310                 315                 320 


Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly 
                325                 330                 335     


Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu 
            340                 345                 350         


Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro 
        355                 360                 365             


Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His Pro Leu 
    370                 375                 380                 


Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys Met Arg 
385                 390                 395                 400 


Cys Asp Ser Leu Met Leu Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                405                 410                 415     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Ala Ala 
            420                 425                 430         


Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val Leu Ala Ala Ala 
        435                 440                 445             


Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys 
    450                 455                 460                 


Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly 
465                 470                 475                 480 


Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn 
                485                 490                 495     


Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe 
            500                 505                 510         


Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys 
        515                 520                 525             


Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Lys 
    530                 535                 540                 


Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Trp Leu Ile Phe Phe Ala 
545                 550                 555                 560 


Ser Leu Gly Ser Phe Leu Ser Ile Leu Leu Val Gly Val Leu Gly Tyr 
                565                 570                 575     


Leu Gly Leu Asn Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr 
            580                 585                 590         


Pro Cys Ala Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp 
        595                 600                 605             


Gln Trp Ile Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu 
    610                 615                 620                 


Ala Leu Val Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro 
625                 630                 635                 640 


Leu Glu Lys Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp 
                645                 650                 655     


Thr Glu Leu Ser Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met 
            660                 665                 670     


<210>  6
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-/IL-12 ICR, TGFRII fused to IL-12R1, TGFRI fused to 
       IL-12R2

<400>  6

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser 
                165                 170                 175     


Phe Leu Ser Ile Leu Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn 
            180                 185                 190         


Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser 
        195                 200                 205             


Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn 
    210                 215                 220                 


Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val 
225                 230                 235                 240 


Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr 
                245                 250                 255     


Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser 
            260                 265                 270         


Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met Gly Ser Gly Ala Thr 
        275                 280                 285             


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
    290                 295                 300                 


Pro Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu 
305                 310                 315                 320 


Val Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala 
                325                 330                 335     


Thr Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr 
            340                 345                 350         


Cys Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp 
        355                 360                 365             


Lys Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro 
    370                 375                 380                 


Arg Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val 
385                 390                 395                 400 


Thr Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu 
                405                 410                 415     


Pro Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Trp 
            420                 425                 430         


Met Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly 
        435                 440                 445             


Ile Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala 
    450                 455                 460                 


Ala Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn 
465                 470                 475                 480 


Ser Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu 
                485                 490                 495     


Pro Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu 
            500                 505                 510         


Pro Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg 
        515                 520                 525             


His Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly 
    530                 535                 540                 


His Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro 
545                 550                 555                 560 


Pro Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr 
                565                 570                 575     


Lys Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala 
            580                 585                 590         


Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly 
        595                 600                 605             


Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu 
    610                 615                 620                 


Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val 
625                 630                 635                 640 


Phe Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys 
                645                 650                 655     


Leu Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
            660                 665                 670     


<210>  7
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-/IL-15 ICR, TGFRII fused to IL-15R, TGFRI fused to 
       c

<400>  7

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Ile Pro Trp Leu Gly His Leu Leu Val Gly 
                165                 170                 175     


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
            180                 185                 190         


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
        195                 200                 205             


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
    210                 215                 220                 


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
225                 230                 235                 240 


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
                245                 250                 255     


Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
            260                 265                 270         


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
        275                 280                 285             


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
    290                 295                 300                 


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
305                 310                 315                 320 


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
                325                 330                 335     


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
            340                 345                 350         


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
        355                 360                 365             


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
    370                 375                 380                 


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
385                 390                 395                 400 


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
                405                 410                 415     


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
            420                 425                 430         


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
        435                 440                 445             


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
    450                 455                 460                 


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Gly Ser Gly 
465                 470                 475                 480 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
                485                 490                 495     


Pro Gly Pro Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu 
            500                 505                 510         


Leu Leu Val Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro 
        515                 520                 525             


Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn 
    530                 535                 540                 


Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr 
545                 550                 555                 560 


Thr Asp Lys Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu 
                565                 570                 575     


Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly 
            580                 585                 590         


Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile 
        595                 600                 605             


Glu Leu Pro Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu 
    610                 615                 620                 


Leu Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu 
625                 630                 635                 640 


Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu 
                645                 650                 655     


Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala 
            660                 665                 670         


Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr 
        675                 680                 685             


Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala 
    690                 695                 700                 


Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr 
705                 710                 715                 720 


Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                725                 730         


<210>  8
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-/IL-15 ICR, TGFRII fused to c, TGFRI fused to 
       IL-15R

<400>  8

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Val Ile Ser Val Gly Ser Met Gly Leu 
                165                 170                 175     


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
            180                 185                 190         


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
        195                 200                 205             


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
    210                 215                 220                 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
225                 230                 235                 240 


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
                245                 250                 255     


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
            260                 265                 270         


Thr Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        275                 280                 285             


Val Glu Glu Asn Pro Gly Pro Met Glu Ala Ala Val Ala Ala Pro Arg 
    290                 295                 300                 


Pro Arg Leu Leu Leu Leu Val Leu Ala Ala Ala Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu Cys 
                325                 330                 335     


Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val Ser 
            340                 345                 350         


Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile Ala 
        355                 360                 365             


Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro Ser 
    370                 375                 380                 


Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp His 
385                 390                 395                 400 


Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Lys Ser Ser Pro Gly Leu 
                405                 410                 415     


Gly Pro Val Glu Leu Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu 
            420                 425                 430         


Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys 
        435                 440                 445             


Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro 
    450                 455                 460                 


Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp 
465                 470                 475                 480 


Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro 
                485                 490                 495     


Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp 
            500                 505                 510         


Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala 
        515                 520                 525             


Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly 
    530                 535                 540                 


Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln 
545                 550                 555                 560 


Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly 
                565                 570                 575     


Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu 
            580                 585                 590         


Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu 
        595                 600                 605             


Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr 
    610                 615                 620                 


Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu 
625                 630                 635                 640 


Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro 
                645                 650                 655     


Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu 
            660                 665                 670         


Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu 
        675                 680                 685             


Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg 
    690                 695                 700                 


Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
705                 710                 715                 720 


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                725                 730         


<210>  9
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-/IL-18 ICR, TGFRII fused to IL-18R, TGFRI fused to 
       IL-18R

<400>  9

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Gly Met Ile Ile Ala Val Leu Ile Leu Val 
                165                 170                 175     


Ala Val Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg Val Asp Leu 
            180                 185                 190         


Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr Leu Thr Asp 
        195                 200                 205             


Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu Cys Arg Pro 
    210                 215                 220                 


Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu Pro Arg Val 
225                 230                 235                 240 


Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu Arg Asp Val 
                245                 250                 255     


Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu Ile Glu Lys 
            260                 265                 270         


Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met Ser Asn Glu 
        275                 280                 285             


Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu Val Glu Arg 
    290                 295                 300                 


Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr Asp Phe Thr 
305                 310                 315                 320 


Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg Val Leu Lys 
                325                 330                 335     


Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe Trp Lys Asn 
            340                 345                 350         


Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly Arg Asp Glu 
        355                 360                 365             


Pro Glu Val Leu Pro Val Leu Ser Glu Ser Gly Ser Gly Ala Thr Asn 
    370                 375                 380                 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
385                 390                 395                 400 


Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
                405                 410                 415     


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            420                 425                 430         


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        435                 440                 445             


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    450                 455                 460                 


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
465                 470                 475                 480 


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                485                 490                 495     


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            500                 505                 510         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Gly Val 
        515                 520                 525             


Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu Val Ala Val 
    530                 535                 540                 


Leu Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu 
545                 550                 555                 560 


Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys 
                565                 570                 575     


Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser 
            580                 585                 590         


Glu Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe 
        595                 600                 605             


Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu Glu 
    610                 615                 620                 


Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile Val Ser Ile 
625                 630                 635                 640 


Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro Asn Tyr Val 
                645                 650                 655     


Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val Asn Leu Ala Leu 
            660                 665                 670         


Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys Phe Cys Tyr Phe Gln 
        675                 680                 685             


Glu Pro Glu Ser Leu Pro His Leu Val Lys Lys Ala Leu Arg Val Leu 
    690                 695                 700                 


Pro Thr Val Thr Trp Arg Gly Leu Lys Ser Val Pro Pro Asn Ser Arg 
705                 710                 715                 720 


Phe Trp Ala Lys Met Arg Tyr His Met Pro Val Lys Asn Ser Gln Gly 
                725                 730                 735     


Phe Thr Trp Asn Gln Leu Arg Ile Thr Ser Arg Ile Phe Gln Trp Lys 
            740                 745                 750         


Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln Pro Lys Glu 
        755                 760                 765             


Trp 
    


<210>  10
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-/IL-18 ICR, TGFRII fused to IL-18R, TGFRI fused to 
       IL-18R

<400>  10

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Gly Val Val Leu Leu Tyr Ile Leu Leu Gly 
                165                 170                 175     


Thr Ile Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr 
            180                 185                 190         


Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys 
        195                 200                 205             


Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr 
    210                 215                 220                 


Ala Lys Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu 
225                 230                 235                 240 


Glu His Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr 
                245                 250                 255     


Gly Tyr Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val 
            260                 265                 270         


Tyr Ala Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile 
        275                 280                 285             


Phe Ile Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu 
    290                 295                 300                 


Gln Ala Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile 
305                 310                 315                 320 


Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu 
                325                 330                 335     


Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu 
            340                 345                 350         


Lys Ser Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His 
        355                 360                 365             


Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile 
    370                 375                 380                 


Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr 
385                 390                 395                 400 


Gly Arg Ser Ser Gln Pro Lys Glu Trp Gly Ser Gly Ala Thr Asn Phe 
                405                 410                 415     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            420                 425                 430         


Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val Leu 
        435                 440                 445             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr Ala 
    450                 455                 460                 


Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
465                 470                 475                 480 


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
                485                 490                 495     


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
            500                 505                 510         


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
        515                 520                 525             


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
    530                 535                 540                 


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Gly Met Ile 
545                 550                 555                 560 


Ile Ala Val Leu Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys 
                565                 570                 575     


Val Ile Tyr Arg Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg 
            580                 585                 590         


Arg Asp Glu Thr Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser 
        595                 600                 605             


Tyr Leu Lys Glu Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala 
    610                 615                 620                 


Val Glu Ile Leu Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu 
625                 630                 635                 640 


Cys Ile Phe Glu Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu 
                645                 650                 655     


Ile His Ser Leu Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser 
            660                 665                 670         


Lys Ser Tyr Met Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu 
        675                 680                 685             


His Glu Ala Leu Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe 
    690                 695                 700                 


Thr Pro Val Thr Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu 
705                 710                 715                 720 


Lys Ser His Arg Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr 
                725                 730                 735     


Asn Ser Arg Phe Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr 
            740                 745                 750         


Val Lys Pro Gly Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu 
        755                 760                 765             


Ser 
    


<210>  11
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-/IL-7 ICR with CPT

<400>  11

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Pro Ile Leu Leu Thr Cys Pro Thr Ile Ser 
                165                 170                 175     


Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val 
            180                 185                 190         


Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp 
        195                 200                 205             


His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu 
    210                 215                 220                 


Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg 
225                 230                 235                 240 


Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
                245                 250                 255     


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
            260                 265                 270         


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
        275                 280                 285             


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
    290                 295                 300                 


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
305                 310                 315                 320 


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
                325                 330                 335     


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
            340                 345                 350         


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
        355                 360                 365             


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
    370                 375                 380                 


Phe Tyr Gln Asn Gln 
385                 


<210>  12
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MSLN CAR1 amino acid sequence

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser His Ile 
        35                  40                  45              


Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        115                 120                 125             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    130                 135                 140                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
145                 150                 155                 160 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                165                 170                 175     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            180                 185                 190         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        195                 200                 205             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    210                 215                 220                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
225                 230                 235                 240 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                245                 250                 255     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            260                 265                 270         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        275                 280                 285             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    290                 295                 300                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
305                 310                 315                 320 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                325                 330                 335     


Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345 


<210>  13
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MSLN CAR2 amino acid sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala His Ile 
        35                  40                  45              


Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        115                 120                 125             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    130                 135                 140                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
145                 150                 155                 160 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                165                 170                 175     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            180                 185                 190         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        195                 200                 205             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    210                 215                 220                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
225                 230                 235                 240 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                245                 250                 255     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            260                 265                 270         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        275                 280                 285             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    290                 295                 300                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
305                 310                 315                 320 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                325                 330                 335     


Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345 


<210>  14
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MSLN CAR3 amino acid sequence

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val Ala His Ile 
        35                  40                  45              


Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        115                 120                 125             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    130                 135                 140                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
145                 150                 155                 160 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                165                 170                 175     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            180                 185                 190         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        195                 200                 205             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    210                 215                 220                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
225                 230                 235                 240 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                245                 250                 255     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            260                 265                 270         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        275                 280                 285             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    290                 295                 300                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
305                 310                 315                 320 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                325                 330                 335     


Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345 


<210>  15
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MSLN CAR4 amino acid sequence

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp Ser Val 
    50                  55                  60                  


Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn Gly Tyr 
            100                 105                 110         


Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        195                 200                 205             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    210                 215                 220                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
225                 230                 235                 240 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                245                 250                 255     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            260                 265                 270         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        275                 280                 285             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    290                 295                 300                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
305                 310                 315                 320 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                325                 330                 335     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345             


<210>  16
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MSLN CAR5 amino acid sequence

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp Ser Val 
    50                  55                  60                  


Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn Gly Tyr 
            100                 105                 110         


Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        195                 200                 205             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    210                 215                 220                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
225                 230                 235                 240 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                245                 250                 255     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            260                 265                 270         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        275                 280                 285             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    290                 295                 300                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
305                 310                 315                 320 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                325                 330                 335     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345             


<210>  17
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MSLN CAR6 amino acid sequence

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp Ser Val 
    50                  55                  60                  


Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn Gly Tyr 
            100                 105                 110         


Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        195                 200                 205             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    210                 215                 220                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
225                 230                 235                 240 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                245                 250                 255     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            260                 265                 270         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        275                 280                 285             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    290                 295                 300                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
305                 310                 315                 320 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                325                 330                 335     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345             


<210>  18
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MSLN CAR7 amino acid sequence

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser Thr Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr 
            100                 105                 110         


Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        195                 200                 205             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    210                 215                 220                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
225                 230                 235                 240 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                245                 250                 255     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            260                 265                 270         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        275                 280                 285             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    290                 295                 300                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
305                 310                 315                 320 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                325                 330                 335     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345             


<210>  19
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MSLN CAR8 amino acid sequence

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser Thr Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr 
            100                 105                 110         


Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        195                 200                 205             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    210                 215                 220                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
225                 230                 235                 240 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                245                 250                 255     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            260                 265                 270         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        275                 280                 285             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    290                 295                 300                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
305                 310                 315                 320 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                325                 330                 335     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345             


<210>  20
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MSLN CAR9 amino acid sequence

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser Thr Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr 
            100                 105                 110         


Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        195                 200                 205             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    210                 215                 220                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
225                 230                 235                 240 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                245                 250                 255     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            260                 265                 270         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        275                 280                 285             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    290                 295                 300                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
305                 310                 315                 320 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                325                 330                 335     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345             


<210>  21
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DLL3 CAR1 amino acid sequence

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Thr Tyr Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn 
        115                 120                 125             


Asn Pro Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  22
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DLL3 CAR2 amino acid sequence

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Thr Tyr Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn 
        115                 120                 125             


Asn Pro Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  23
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DLL3 CAR3 amino acid sequence

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ala 
        35                  40                  45              


Thr Tyr Ser Thr Asn Tyr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ala Val Ala Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Asn Leu Arg Ile Gly Gly Asp Trp Phe 
        115                 120                 125             


Asp Gly Arg Asp Phe Arg Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  24
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DLL3 CAR4 amino acid sequence

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
        35                  40                  45              


Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
        115                 120                 125             


Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  25
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DLL3 CAR5 amino acid sequence

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Thr Tyr Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn 
        115                 120                 125             


Asn Pro Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
            180                 185                 190         


Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
        195                 200                 205             


Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
    210                 215                 220                 


Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
            260                 265                 270         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  26
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DLL3 CAR6 amino acid sequence

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
        35                  40                  45              


Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
        115                 120                 125             


Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
            180                 185                 190         


Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
        195                 200                 205             


Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
    210                 215                 220                 


Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
            260                 265                 270         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  27
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DLL3 CAR7 amino acid sequence

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
        35                  40                  45              


Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
        115                 120                 125             


Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser Gly Tyr Gly Val 
            180                 185                 190         


Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly 
        195                 200                 205             


Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser 
    210                 215                 220                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr 
                245                 250                 255     


Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg 
            260                 265                 270         


Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


