                         SEQUENCE LISTING

<110>  ɽҽҩ޹˾
 
<120>  CD73Ŀ弰;

<130>  IP200556

<160>  24    

<170>  PatentIn version 3.3

<210>  1
<211>  363
<212>  DNA
<213>  ˹

<220>
<223>  19F3ɱĺ

<400>  1
gaggtgcagc tgcagcagtc cggaccagag ctggtgaagc ctggcgcctc catgcggatg     60

tcttgtaagg cctctggcta cagcttcacc ggctatacaa tgaactgggt gaagcagtct    120

cacggcaaga atctggagtg gatcggcctg atcaaccctt acaatgccgg caccagctat    180

aaccagaagt ttaagggcaa ggccaccctg acagtggaca agagctcctc taccgcctac    240

atggagctgc tgtccctgac atctgaggat agcgccgtgt actattgcgc ccggtccgag    300

tacagatatg gcggcgacta ctttgattat tggggccagg gcaccacact gacagtgagc    360

tcc                                                                  363


<210>  2
<211>  121
<212>  PRT
<213>  ˹

<220>
<223>  19F3ɱİ

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Arg Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Ala Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Tyr Arg Tyr Gly Gly Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  19F3ɱĺ

<400>  3
gacatcgtga tgacccagtc tccaagctcc ctggcaatga gcgtgggaca gaaggtgaca     60

atgtcttgta agtctagcca gagcctgctg aactcctcta atcagaagaa ctacctggcc    120

tggtatcagc agaagccagg ccagtctccc aagctgctgg tgtactttgc cagcaccagg    180

gagtccggag tgcctgacag attcatcggc tccggctctg gcacagactt caccctgaca    240

atcagctccg tgcaggcaga ggacctggca gattatttct gccagcagca ctacgacacc    300

ccttatacat ttggcggcgg caccaagctg gagatcaag                           339


<210>  4
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  19F3ɱİ

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  5
<211>  363
<212>  DNA
<213>  ˹

<220>
<223>  19F3H1L1ɱĺ

<400>  5
caggtgcagc tgcagcagtc tggagcagag gtggtgaagc caggagcctc tatgaagatg     60

agctgtaagg ccagcggcta ctccttcacc ggctatacaa tgaactgggt gaagcaggcc    120

cacggccaga atctggagtg gatcggcctg atcaaccctt acaatgccgg cacctcttat    180

aaccagaagt ttcagggcaa ggccaccctg acagtggaca agtccacctc tacagcctac    240

atggagctga gctccctgcg gagcgaggat acagccgtgt actattgcgc ccggtccgag    300

tacagatatg gcggcgacta ctttgattat tggggccagg gcaccacact gaccgtgtct    360

agc                                                                  363


<210>  6
<211>  121
<212>  PRT
<213>  ˹

<220>
<223>  19F3H1L1ɱİ

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ala His Gly Gln Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Ala Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Tyr Arg Tyr Gly Gly Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  19F3H1L1ɱĺ

<400>  7
gacatcgtga tgacccagtc cccaagctcc ctggcaatgt ctgtgggaga gagggtgaca     60

atgtcctgta agtctagcca gtctctgctg aactcctcta atcagaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccaggcccct aagctgctgg tgtactttgc ctctaccagg    180

gagagcggag tgccagacag attctctggc agcggctccg gcacagactt caccctgaca    240

atcagctccg tgcaggcaga ggacctggca gattatttct gccagcagca ctacgatacc    300

ccctatacat ttggcggcgg caccaagctg gagatcaag                           339


<210>  8
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  19F3H1L1ɱİ

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  9
<211>  363
<212>  DNA
<213>  ˹

<220>
<223>  19F3H2L219F3H2L3ɱĺ

<400>  9
caggtgcagc tggtgcagtc tggagcagag gtggtgaagc caggagcctc tgtgaaggtg     60

agctgtaagg ccagcggcta ctccttcacc ggctatacaa tgaactgggt gaggcaggca    120

ccaggacaga atctggagtg gatcggcctg atcaaccctt acaatgccgg cacctcttat    180

aaccagaagt ttcagggcaa ggtgaccctg acagtggaca agtccacctc tacagcctac    240

atggagctga gctccctgcg gagcgaggat acagccgtgt actattgcgc ccggtccgag    300

tacagatatg gcggcgacta ctttgattat tggggccagg gcaccacact gaccgtgtct    360

agc                                                                  363


<210>  10
<211>  121
<212>  PRT
<213>  ˹

<220>
<223>  19F3H2L219F3H2L3ɱİ

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Ala Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Tyr Arg Tyr Gly Gly Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  11
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  19F3H2L2ɱĺ

<400>  11
gacatcgtga tgacccagtc cccaagctcc ctggccgtgt ctgtgggaga gcgggtgaca     60

atctcctgta agtctagcca gtctctgctg aactcctcta atcagaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccaggcccct aagctgctga tctacttcgc ctctaccagg    180

gagagcggag tgccagacag attctctggc agcggctccg gcacagactt caccctgaca    240

atcagctccg tgcaggcaga ggacgtggca gattactatt gccagcagca ctacgatacc    300

ccctatacat ttggcggcgg caccaagctg gagatcaag                           339


<210>  12
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  19F3H2L2ɱİ

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Asp Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  13
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  19F3H2L3ɱĺ

<400>  13
gacatcgtga tgacccagtc cccaagctcc ctggccgtgt ctgtgggaga gcgggtgaca     60

atctcctgta agtctagcca gtctctgctg aactcctcta atcagaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccaggcccct aagctgctga tctacttcgc ctctaccagg    180

gagagcggag tgccagacag attctctggc agcggctccg gcacagactt caccctgaca    240

atcagctccc tgcaggcaga ggacgtggcc gtgtactatt gccagcagca ctacgatacc    300

ccctatacat ttggcggcgg caccaagctg gagatcaag                           339


<210>  14
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  19F3H2L3ɱİ

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  15
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  19F319F3H2L3HCDR1İ

<400>  15

Gly Tyr Ser Phe Thr Gly Tyr Thr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  19F319F3H2L3HCDR2İ

<400>  16

Ile Asn Pro Tyr Asn Ala Gly Thr 
1               5               


<210>  17
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  19F319F3H2L3HCDR3İ

<400>  17

Ala Arg Ser Glu Tyr Arg Tyr Gly Gly Asp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  18
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  19F319F3H2L3LCDR1İ

<400>  18

Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  19
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  19F319F3H2L3LCDR2İ

<400>  19

Phe Ala Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  19F319F3H2L3LCDR3İ

<400>  20

Gln Gln His Tyr Asp Thr Pro Tyr Thr 
1               5                   


<210>  21
<211>  452
<212>  PRT
<213>  ˹

<220>
<223>  CPI-006 

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Thr Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Gly Leu Thr Thr Glu Asp Tyr Ala Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  22
<211>  218
<212>  PRT
<213>  ˹

<220>
<223>  CPI-006 

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Asn Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Asn Ile Glu Ser Glu Asp Ala Ala Tyr Tyr Phe Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  23
<211>  451
<212>  PRT
<213>  ˹

<220>
<223>  19F3H2L3(hG1DM)ȫ

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Ala Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Tyr Arg Tyr Gly Gly Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  24
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  19F3H2L3(hG1DM)ȫ

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


