﻿                         序列表

<110>  正大天晴药业集团股份有限公司

<120>  结合BCMA的单可变结构域及抗原结合分子

<160>  27

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  23
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  Call001引物序列


<400>  1
gtcctggctg ctcttctaca agg                                                23

<210>  2
<211>  23
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  Call002引物序列


<400>  2
ggtacgtgct gttgaactgt tcc                                                23

<210>  3
<211>  29
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  V-Back引物序列


<400>  3
gatgtgcagc tgcaggagtc tggrggagg                                          29

<210>  4
<211>  34
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  V-Fwd引物序列


<400>  4
ctagtgcggc cgctgaggag acggtgacct gggt                                    34

<210>  5
<211>  232
<212>  PRT
<213>  人(Homo sapiens)

<400>  5
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         

<210>  6
<211>  54
<212>  PRT
<213>  人(Homo sapiens)

<400>  6
Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      
Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          
Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              
Val Lys Gly Thr Asn Ala 
    50                  

<210>  7
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  7
Pro Cys Ala Met Gly 
1               5   

<210>  8
<211>  16
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  8
Trp Ile Thr Val Asp Gly Thr Thr Asp Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  9
<211>  12
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  9
Val Tyr Ile Leu Thr Pro Ser Cys Arg Pro Gln Pro 
1               5                   10          

<210>  10
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  10
Ser Asp Cys Met Gly 
1               5   

<210>  11
<211>  17
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  11
Arg Ile Glu Thr Gly Tyr Gly Gly Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  12
<211>  17
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  12
Lys Arg Ser Trp Cys Ser Pro Thr Trp Trp Arg Glu Val Asp Tyr Asn 
1               5                   10                  15      
Tyr 
    

<210>  13
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  13
Met Val Cys Met Gly 
1               5   

<210>  14
<211>  17
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  14
Leu Ile Thr Thr Asp Gly Gly Thr Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  15
<211>  18
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  15
Asp Asp Arg Pro Trp Cys Met Thr Val Gly Val Arg Thr Glu Asp Tyr 
1               5                   10                  15      
Asp Thr 
        

<210>  16
<211>  120
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  16
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Leu Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Pro Cys 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Leu Val 
        35                  40                  45              
Ser Trp Ile Thr Val Asp Gly Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Thr Ser Leu Glu Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Val Tyr Ile Leu Thr Pro Ser Cys Arg Pro Gln Pro Trp Gly Pro 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 

<210>  17
<211>  360
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<400>  17
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctattactc        60
tcctgtgcag cctctggata caccttcagt ccctgcgcca tgggctggtt ccgccaggct       120
ccagggaagg agcgctcgtt ggtctcatgg attactgttg atggtacaac agactatgca       180
gactccgtga agggccgatt caccatctcc cgagacaacg ccaagaacat ggtgtatctg       240
caaatgacta gtttggaacc tgaggacacg gccacgtatt actgtaatac tgtgtacatt       300
cttactccgt cctgccgccc ccagccctgg ggcccgggga cccaggtcac tgtctcatca       360

<210>  18
<211>  126
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  18
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Asn Ser Asp 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              
Ala Arg Ile Glu Thr Gly Tyr Gly Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Ser Pro Thr Trp Trp Arg Glu Val Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210>  19
<211>  378
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<400>  19
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc        60
tcctgtgcag cctctggagt cacttttaat agtgactgta tgggttggtt ccgccaggct       120
ccgggaaagg agcgcgaggc agtcgcacgt attgaaactg gttatggtgg cactctctat       180
gccgactccg tgaagggacg attcaccatc tcccgagaca acgccaagaa gacggtgtat       240
ctgcaaatga acagcctaaa atttgaggac actgccatgt actactgtgc ggctaagaga       300
tcctggtgtt ctcctacgtg gtggcgcgaa gttgactata actactgggg acaggggacc       360
ctggtcactg tctcatca                                                     378

<210>  20
<211>  127
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  20
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Pro Ala Gly Gly 
1               5                   10                  15      
Ser Met Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Asn Pro Met Val 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu Gly Val 
        35                  40                  45              
Ala Leu Ile Thr Thr Asp Gly Gly Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Thr Cys 
                85                  90                  95      
Ala Ala Asp Asp Arg Pro Trp Cys Met Thr Val Gly Val Arg Thr Glu 
            100                 105                 110         
Asp Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         

<210>  21
<211>  381
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<400>  21
caggtgcagc tggtggagtc tgggggaggc tcggtgcctg ctggagggtc tatgagactc        60
tcctgtgcag cctctggtta caggaatcct atggtgtgta tgggctggtt tcgccaggct       120
ccagggaaga agcgcgaggg ggtcgcactt attactactg atggtggaac cacactctac       180
gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat       240
ctgcaaatga acaacctgaa accagaggac actgccatgt acacctgtgc ggcagacgac       300
cgtccctggt gtatgacggt tggtgtgagg acggaagact atgacacctg gggccagggg       360
accctggtca ctgtctcatc a                                                 381

<210>  22
<211>  352
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A5-Fc的全长氨基酸序列


<400>  22
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Leu Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Pro Cys 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Leu Val 
        35                  40                  45              
Ser Trp Ile Thr Val Asp Gly Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Thr Ser Leu Glu Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn 
                85                  90                  95      
Thr Val Tyr Ile Leu Thr Pro Ser Cys Arg Pro Gln Pro Trp Gly Pro 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr 
        115                 120                 125             
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         

<210>  23
<211>  1056
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A5-Fc的全长核苷酸序列


<400>  23
caagtgcaac tggtggagtc tggaggcggt tccgtgcagg ccggcggctc cctgctcctg        60
tcctgcgccg cttccggcta caccttctct ccttgtgcca tgggctggtt ccggcaggct       120
cctggcaaag aaagatccct ggtgtcttgg atcaccgtgg atggcaccac cgattacgct       180
gactccgtga agggcagatt caccatctct agagacaacg ccaagaacat ggtgtacctg       240
cagatgacca gcctggaacc tgaggatacc gctacctact actgcaacac cgtgtacatc       300
ctgacaccta gctgccggcc tcaaccttgg ggacctggaa cacaggtaac cgtgtcgtcc       360
gagcccaagt cttgcgacaa gacccacacc tgtcctcctt gtcctgctcc ggaactgctg       420
ggcggccctt ccgtgtttct gtttcctcca aagcctaagg acacactgat gatcagccgg       480
acccctgagg tgacctgcgt ggtcgtggat gtctctcacg aggatcctga ggtgaagttc       540
aactggtacg tggatggagt ggaagtgcat aacgctaaaa ccaagcctag agaagagcag       600
tacaactcca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac       660
ggcaaagagt acaagtgcaa ggtgtccaac aaggctctgc ctgcccctat cgagaagacc       720
atctccaagg ccaagggcca gcctcgggag cctcaagtgt acaccctgcc tccttctcgc       780
gacgagctga ccaagaacca ggtgtctctg acctgcctgg tgaaaggctt ctacccctcc       840
gacatcgccg tggaatggga gtccaatggc cagcccgaga acaactacaa gaccacccca       900
cctgtgctgg actctgatgg ctccttcttc ctgtactcca agctgaccgt ggacaagtcc       960
agatggcagc agggcaacgt gttctcctgt tctgtgatgc acgaggccct gcacaaccac      1020
tacacacaga agtccctgag cctgtctcct ggcaag                                1056

<210>  24
<211>  358
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1B5-Fc的全长氨基酸序列


<400>  24
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Asn Ser Asp 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              
Ala Arg Ile Glu Thr Gly Tyr Gly Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Ser Pro Thr Trp Trp Arg Glu Val Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
        115                 120                 125             
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            260                 265                 270         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         
Ser Leu Ser Pro Gly Lys 
        355             

<210>  25
<211>  1074
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1B5-Fc的全长核苷酸序列


<400>  25
caggtgcagt tggttgaatc tggcggcgga tctgtgcagg ctggcggatc tctgagactg        60
tcctgtgccg cttccggcgt caccttcaac tccgactgca tgggatggtt cagacaggcc       120
cctggcaaag agagagaggc cgtcgctagg atcgagaccg gctatggcgg aaccctgtac       180
gccgactccg tcaagggcag gttcaccatc agcagagaca acgccaagaa gaccgtgtac       240
ctgcagatga actccctgaa gttcgaggac accgccatgt actactgtgc tgccaagaga       300
agctggtgca gccctacctg gtggagagag gtggactaca actactgggg ccagggcaca       360
ctggtcaccg tgtcctctga gcctaagtcc tgcgacaaga cccacacctg tcctccatgt       420
cctgctccag aactgctcgg cggaccttcc gtgttcctgt ttcctccaaa gcctaaggat       480
accctgatga tctctcggac ccctgaagtg acctgcgtgg tggtggatgt gtctcacgag       540
gatcccgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa tgctaagacc       600
aagcctagag aggaacagta caactccacc tatagagtgg tgtccgtgct gaccgtgctg       660
caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct       720
gctcctatcg aaaagaccat ctccaaggcc aagggccagc ctagggaacc ccaggtttac       780
accttgcctc catctcggga cgagctgacc aagaaccagg tgtccctgac ctgtctggtc       840
aagggcttct acccctccga tatcgccgtg gaatgggagt ctaatggcca gccagagaac       900
aactacaaga caacccctcc tgtgctggac tccgacggct cattcttcct gtactccaag       960
ctgacagtgg acaagtccag atggcagcag ggcaacgtgt tctcctgctc cgtgatgcac      1020
gaggccctgc acaatcacta cacccagaag tccctgtctc tgagccccgg caaa            1074

<210>  26
<211>  359
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1B11-Fc的全长氨基酸序列


<400>  26
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Pro Ala Gly Gly 
1               5                   10                  15      
Ser Met Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Asn Pro Met Val 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu Gly Val 
        35                  40                  45              
Ala Leu Ile Thr Thr Asp Gly Gly Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Thr Cys 
                85                  90                  95      
Ala Ala Asp Asp Arg Pro Trp Cys Met Thr Val Gly Val Arg Thr Glu 
            100                 105                 110         
Asp Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu 
        115                 120                 125             
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         
Leu Ser Leu Ser Pro Gly Lys 
        355                 

<210>  27
<211>  1077
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1B11-Fc的全长核苷酸序列


<400>  27
caggtgcagt tggttgaatc tggcggcgga tctgtgcccg ctggcggatc tatgagactg        60
tcctgtgccg cttccggcta cagaaacccc atggtctgca tgggctggtt cagacaggcc       120
cctggcaaga agagagaagg cgtcgccctg atcaccaccg atggcggaac aacattgtac       180
gccgactccg tcaagggcag gttcaccatc agccaggaca acgccaagaa caccgtgtac       240
ctgcagatga acaatctgaa gcccgaggac accgccatgt acacctgtgc cgccgacgac       300
agaccttggt gtatgaccgt gggcgtcaga accgaggact acgacacatg gggccaggga       360
acactggtca ccgtgtcctc tgagcctaag tcctgcgaca agacccacac ctgtcctcca       420
tgtcctgctc cagaactgct cggcggacct tccgtgttcc tgtttcctcc aaagcctaag       480
gataccctga tgatctctcg gacccctgaa gtgacctgcg tggtggtgga tgtgtctcac       540
gaggatcccg aagtgaagtt caattggtac gtggacggcg tggaagtgca caatgctaag       600
accaagccta gagaggaaca gtacaactcc acctatagag tggtgtccgt gctgaccgtg       660
ctgcaccagg attggctgaa cggcaaagag tacaagtgca aggtgtccaa caaggccctg       720
cctgctccta tcgaaaagac catctccaag gccaagggcc agcctaggga accccaggtt       780
tacaccttgc ctccatctcg ggacgagctg accaagaacc aggtgtccct gacctgtctg       840
gtcaagggct tctacccctc cgatatcgcc gtggaatggg agtctaatgg ccagccagag       900
aacaactaca agacaacccc tcctgtgctg gactccgacg gctcattctt cctgtactcc       960
aagctgacag tggacaagtc cagatggcag cagggcaacg tgttctcctg ctccgtgatg      1020
cacgaggccc tgcacaatca ctacacccag aagtccctgt ctctgagccc cggcaaa         1077

