                         SEQUENCE LISTING

<110>  UTC Therapeutics Inc.
 
<120>  LYMPHOCYTES-ANTIGEN PRESENTING CELLS CO-STIMULATORS AND USES 
       THEREOF

<130>  613A001WO02

<150>  PCT/CN2020/109484
<151>  2020-08-17

<160>  225   

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  T4 fibritin trimerization motif

<400>  1

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  2
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  Isoleucine Zipper (L)

<400>  2

Glu Lys Lys Ile Glu Ala Ile Glu Lys Lys Ile Glu Ala Ile Glu Lys 
1               5                   10                  15      


Lys Ile Glu Ala Ile Glu Ala Ile Glu Lys Lys Ile Glu Ala 
            20                  25                  30  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Isoleucine Zipper (S)

<400>  3

Glu Lys Lys Ile Glu Ala Ile Glu Lys Lys Ile Glu Ala Ile Glu Lys 
1               5                   10                  15      


Lys Ile Glu Ala 
            20  


<210>  4
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4II

<400>  4

Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr His Ile Glu Asn 
1               5                   10                  15      


Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Ala 
            20                  25              


<210>  5
<211>  28
<212>  PRT
<213>  artificial

<220>
<223>  Optimized GCN4II

<400>  5

Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Ile Tyr His Ile Glu Asn 
1               5                   10                  15      


Arg Ile Ala Arg Ile Glu Lys Leu Val Gly Glu Ala 
            20                  25              


<210>  6
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  Matrilin -1 (L)

<400>  6

Glu Glu Asp Pro Cys Glu Cys Lys Ser Ile Val Lys Phe Gln Thr Lys 
1               5                   10                  15      


Val Glu Glu Leu Ile Asn Thr Leu Gln Gln Lys Leu Glu Ala Val Ala 
            20                  25                  30          


Lys Arg Ile Glu Ala Leu Glu Asn Lys Ile Ile 
        35                  40              


<210>  7
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  Matrilin -1 (S)

<400>  7

Glu Glu Leu Ile Asn Thr Leu Gln Gln Lys Leu Glu Ala Val Ala Lys 
1               5                   10                  15      


Arg Ile Glu Ala Leu Glu Asn Lys Ile Ile 
            20                  25      


<210>  8
<211>  64
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human collagen XV trimerization domain

<400>  8

Val Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala His Leu 
1               5                   10                  15      


Val Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu Phe Phe 
            20                  25                  30          


Ile Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu Leu Ile 
        35                  40                  45              


Pro Ile Pro Ala Asp Ser Pro Pro Pro Pro Ala Leu Ser Ser Asn Pro 
    50                  55                  60                  


<210>  9
<211>  261
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CD40L full length

<400>  9

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  10
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CD40L transmembrane domain

<400>  10

Ile Phe Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly 
1               5                   10                  15      


Ser Ala Leu Phe Ala Val Tyr Leu 
            20                  


<210>  11
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CD40L intracellular domain

<400>  11

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys 
            20          


<210>  12
<211>  215
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CD40L extracellular domain

<400>  12

His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp 
1               5                   10                  15      


Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser 
            20                  25                  30          


Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe 
        35                  40                  45              


Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser 
    50                  55                  60                  


Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
65                  70                  75                  80  


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
                85                  90                  95      


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
            100                 105                 110         


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
        115                 120                 125             


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
    130                 135                 140                 


Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
145                 150                 155                 160 


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
                165                 170                 175     


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
            180                 185                 190         


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
        195                 200                 205             


Ser Phe Gly Leu Leu Lys Leu 
    210                 215 


<210>  13
<211>  220
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CD28 full length

<400>  13

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  14
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CD28 intracellular domain

<400>  14

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  15
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CD28 transmembrane domain

<400>  15

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  16
<211>  255
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human 4-1BB full length

<400>  16

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  17
<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human 4-1BB intracellular domain

<400>  17

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  18
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human 4-1BB transmembrane domain

<400>  18

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  19
<211>  199
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human ICOS full length

<400>  19

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  20
<211>  38
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human ICOS intracellular domain

<400>  20

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  21
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human ICOS transmembrane domain

<400>  21

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  22
<211>  260
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD27 full length

<400>  22

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  23
<211>  48
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD27 intracellular domain

<400>  23

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  24
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD27 transmembrane domain

<400>  24

Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210>  25
<211>  277
<212>  PRT
<213>  artificial sequence

<220>
<223>  OX40 full length

<400>  25

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  26
<211>  42
<212>  PRT
<213>  artificial

<220>
<223>  OX40 intracellular domain

<400>  26

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  27
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  OX40 transmembrane domain

<400>  27

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210>  28
<211>  93
<212>  PRT
<213>  artificial sequence

<220>
<223>  DAP10 full length

<400>  28

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90              


<210>  29
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  DAP10 intracellular domain

<400>  29

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  30
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  DAP10 transmembrane domain

<400>  30

Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
1               5                   10                  15      


Val Gly Ala Val Phe 
            20      


<210>  31
<211>  595
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD30 full length

<400>  31

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  32
<211>  189
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD30 intracellular domain

<400>  32

Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu 
1               5                   10                  15      


Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser 
            20                  25                  30          


Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr 
        35                  40                  45              


Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu 
    50                  55                  60                  


Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln 
65                  70                  75                  80  


Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu 
                85                  90                  95      


Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr 
            100                 105                 110         


Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu 
        115                 120                 125             


Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu 
    130                 135                 140                 


Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu 
145                 150                 155                 160 


Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu 
                165                 170                 175     


Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185                 


<210>  33
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD30 transmembrane domain

<400>  33

Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly Ser 
1               5                   10                  15      


Ser Ala Phe Leu Leu 
            20      


<210>  34
<211>  370
<212>  PRT
<213>  artificial sequence

<220>
<223>  2B4 full length

<400>  34

Met Leu Gly Gln Val Val Thr Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Glu Ser 
        115                 120                 125             


Leu Leu Pro Asp Lys Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys 
    130                 135                 140                 


Ile Leu Asp Arg Gly Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser 
145                 150                 155                 160 


Arg Asp Gly Asn Val Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile 
                165                 170                 175     


Gln Thr Ala Gly Asn Leu Thr Tyr Leu Asp Glu Glu Val Asp Ile Asn 
            180                 185                 190         


Gly Thr His Thr Tyr Thr Cys Asn Val Ser Asn Pro Val Ser Trp Glu 
        195                 200                 205             


Ser His Thr Leu Asn Leu Thr Gln Asp Cys Gln Asn Ala His Gln Glu 
    210                 215                 220                 


Phe Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys 
                245                 250                 255     


Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu 
            260                 265                 270         


Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr 
        275                 280                 285             


Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser 
    290                 295                 300                 


Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile 
305                 310                 315                 320 


Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser 
                325                 330                 335     


Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala 
            340                 345                 350         


Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val 
        355                 360                 365             


Tyr Ser 
    370 


<210>  35
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  2B4 intracellular domain

<400>  35

Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu 
1               5                   10                  15      


Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn 
            20                  25                  30          


His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser 
        35                  40                  45              


Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr 
    50                  55                  60                  


Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys 
65                  70                  75                  80  


Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly 
                85                  90                  95      


Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu 
            100                 105                 110         


Leu Glu Asn Phe Asp Val Tyr Ser 
        115                 120 


<210>  36
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  2B4 transmembrane domain

<400>  36

Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
1               5                   10                  15      


Ala Cys Phe Cys Val 
            20      


<210>  37
<211>  351
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD2 full length

<400>  37

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  38
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD2 intracellular domain

<400>  38

Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser Asn 
        115     


<210>  39
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD2 transmembrane domain

<400>  39

Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val 
1               5                   10                  15      


Phe Val Ala Leu Leu Val Phe Tyr Ile Thr 
            20                  25      


<210>  40
<211>  240
<212>  PRT
<213>  artificial sequence

<220>
<223>  LIGHT full length

<400>  40

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  41
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  LIGHT intracellular domain

<400>  41

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg 
        35          


<210>  42
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  LIGHT transmembrane domain

<400>  42

Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly Ala Gly Leu Ala Val 
1               5                   10                  15      


Gln Gly Trp Phe Leu 
            20      


<210>  43
<211>  241
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR full length

<400>  43

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  44
<211>  58
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR intracellular domain

<400>  44

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  45
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR transmembrane domain

<400>  45

Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys Val Leu 
1               5                   10                  15      


Leu Leu Thr Ser Ala 
            20      


<210>  46
<211>  417
<212>  PRT
<213>  artificial sequence

<220>
<223>  DR3 full length

<400>  46

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr Ser Thr Leu Gly Ser Cys Pro Glu Arg Cys Ala 
            180                 185                 190         


Ala Val Cys Gly Trp Arg Gln Met Phe Trp Val Gln Val Leu Leu Ala 
        195                 200                 205             


Gly Leu Val Val Pro Leu Leu Leu Gly Ala Thr Leu Thr Tyr Thr Tyr 
    210                 215                 220                 


Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala Gly 
225                 230                 235                 240 


Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp 
                245                 250                 255     


Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys 
            260                 265                 270         


Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr 
        275                 280                 285             


Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro 
    290                 295                 300                 


Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser 
305                 310                 315                 320 


Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr 
                325                 330                 335     


Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg 
            340                 345                 350         


Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile 
        355                 360                 365             


Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln 
    370                 375                 380                 


Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met 
385                 390                 395                 400 


Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly 
                405                 410                 415     


Pro 
    


<210>  47
<211>  197
<212>  PRT
<213>  artificial sequence

<220>
<223>  DR3 intracellular domain

<400>  47

Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala 
1               5                   10                  15      


Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu 
            20                  25                  30          


Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser 
        35                  40                  45              


Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly 
    50                  55                  60                  


Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp 
65                  70                  75                  80  


Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu 
                85                  90                  95      


Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly 
            100                 105                 110         


Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys 
        115                 120                 125             


Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val 
    130                 135                 140                 


Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys 
145                 150                 155                 160 


Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala 
                165                 170                 175     


Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg 
            180                 185                 190         


Leu Gln Arg Gly Pro 
        195         


<210>  48
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  DR3 transmembrane domain

<400>  48

Met Phe Trp Val Gln Val Leu Leu Ala Gly Leu Val Val Pro Leu Leu 
1               5                   10                  15      


Leu Gly Ala Thr Leu 
            20      


<210>  49
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD160 full length

<400>  49

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala Leu 
            180     


<210>  50
<211>  400
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD43 full length

<400>  50

Met Ala Thr Leu Leu Leu Leu Leu Gly Val Leu Val Val Ser Pro Asp 
1               5                   10                  15      


Ala Leu Gly Ser Thr Thr Ala Val Gln Thr Pro Thr Ser Gly Glu Pro 
            20                  25                  30          


Leu Val Ser Thr Ser Glu Pro Leu Ser Ser Lys Met Tyr Thr Thr Ser 
        35                  40                  45              


Ile Thr Ser Asp Pro Lys Ala Asp Ser Thr Gly Asp Gln Thr Ser Ala 
    50                  55                  60                  


Leu Pro Pro Ser Thr Ser Ile Asn Glu Gly Ser Pro Leu Trp Thr Ser 
65                  70                  75                  80  


Ile Gly Ala Ser Thr Gly Ser Pro Leu Pro Glu Pro Thr Thr Tyr Gln 
                85                  90                  95      


Glu Val Ser Ile Lys Met Ser Ser Val Pro Gln Glu Thr Pro His Ala 
            100                 105                 110         


Thr Ser His Pro Ala Val Pro Ile Thr Ala Asn Ser Leu Gly Ser His 
        115                 120                 125             


Thr Val Thr Gly Gly Thr Ile Thr Thr Asn Ser Pro Glu Thr Ser Ser 
    130                 135                 140                 


Arg Thr Ser Gly Ala Pro Val Thr Thr Ala Ala Ser Ser Leu Glu Thr 
145                 150                 155                 160 


Ser Arg Gly Thr Ser Gly Pro Pro Leu Thr Met Ala Thr Val Ser Leu 
                165                 170                 175     


Glu Thr Ser Lys Gly Thr Ser Gly Pro Pro Val Thr Met Ala Thr Asp 
            180                 185                 190         


Ser Leu Glu Thr Ser Thr Gly Thr Thr Gly Pro Pro Val Thr Met Thr 
        195                 200                 205             


Thr Gly Ser Leu Glu Pro Ser Ser Gly Ala Ser Gly Pro Gln Val Ser 
    210                 215                 220                 


Ser Val Lys Leu Ser Thr Met Met Ser Pro Thr Thr Ser Thr Asn Ala 
225                 230                 235                 240 


Ser Thr Val Pro Phe Arg Asn Pro Asp Glu Asn Ser Arg Gly Met Leu 
                245                 250                 255     


Pro Val Ala Val Leu Val Ala Leu Leu Ala Val Ile Val Leu Val Ala 
            260                 265                 270         


Leu Leu Leu Leu Trp Arg Arg Arg Gln Lys Arg Arg Thr Gly Ala Leu 
        275                 280                 285             


Val Leu Ser Arg Gly Gly Lys Arg Asn Gly Val Val Asp Ala Trp Ala 
    290                 295                 300                 


Gly Pro Ala Gln Val Pro Glu Glu Gly Ala Val Thr Val Thr Val Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Asp Lys Gly Ser Gly Phe Pro Asp Gly Glu Gly Ser 
                325                 330                 335     


Ser Arg Arg Pro Thr Leu Thr Thr Phe Phe Gly Arg Arg Lys Ser Arg 
            340                 345                 350         


Gln Gly Ser Leu Ala Met Glu Glu Leu Lys Ser Gly Ser Gly Pro Ser 
        355                 360                 365             


Leu Lys Gly Glu Glu Glu Pro Leu Val Ala Ser Glu Asp Gly Ala Val 
    370                 375                 380                 


Asp Ala Pro Ala Pro Asp Glu Pro Glu Gly Gly Asp Gly Ala Ala Pro 
385                 390                 395                 400 


<210>  51
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD43 intracellular domain

<400>  51

Trp Arg Arg Arg Gln Lys Arg Arg Thr Gly Ala Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Gly Lys Arg Asn Gly Val Val Asp Ala Trp Ala Gly Pro Ala Gln 
            20                  25                  30          


Val Pro Glu Glu Gly Ala Val Thr Val Thr Val Gly Gly Ser Gly Gly 
        35                  40                  45              


Asp Lys Gly Ser Gly Phe Pro Asp Gly Glu Gly Ser Ser Arg Arg Pro 
    50                  55                  60                  


Thr Leu Thr Thr Phe Phe Gly Arg Arg Lys Ser Arg Gln Gly Ser Leu 
65                  70                  75                  80  


Ala Met Glu Glu Leu Lys Ser Gly Ser Gly Pro Ser Leu Lys Gly Glu 
                85                  90                  95      


Glu Glu Pro Leu Val Ala Ser Glu Asp Gly Ala Val Asp Ala Pro Ala 
            100                 105                 110         


Pro Asp Glu Pro Glu Gly Gly Asp Gly Ala Ala Pro 
        115                 120                 


<210>  52
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD43 transmembrane domain

<400>  52

Gly Met Leu Pro Val Ala Val Leu Val Ala Leu Leu Ala Val Ile Val 
1               5                   10                  15      


Leu Val Ala Leu Leu Leu Leu 
            20              


<210>  53
<211>  243
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD48 full length

<400>  53

Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210>  54
<211>  288
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD80 full length

<400>  54

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  55
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD80 intracellular domain

<400>  55

Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg Asn Glu Arg 
1               5                   10                  15      


Leu Arg Arg Glu Ser Val Arg Pro Val 
            20                  25  


<210>  56
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD 80 transmembrane domain

<400>  56

Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
1               5                   10                  15      


Val Ile Cys Cys Leu 
            20      


<210>  57
<211>  329
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD 86 full length

<400>  57

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  58
<211>  61
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD 86 intracellular domain

<400>  58

Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr 
1               5                   10                  15      


Asn Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
            20                  25                  30          


Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser 
        35                  40                  45              


Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe 
    50                  55                  60      


<210>  59
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD 86 transmembrane domain

<400>  59

Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val Phe 
1               5                   10                  15      


Cys Leu Ile Leu Trp 
            20      


<210>  60
<211>  4544
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CD 91/LRP1 full length

<400>  60

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu 
                405                 410                 415     


Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn 
            420                 425                 430         


Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr 
        435                 440                 445             


Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile 
    450                 455                 460                 


Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn 
465                 470                 475                 480 


Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala 
                485                 490                 495     


Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu 
            500                 505                 510         


Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu 
        515                 520                 525             


Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly 
    530                 535                 540                 


Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn 
545                 550                 555                 560 


Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala 
                565                 570                 575     


Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu 
            580                 585                 590         


Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala 
        595                 600                 605             


Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys 
    610                 615                 620                 


Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys 
625                 630                 635                 640 


Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp 
                645                 650                 655     


Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys 
            660                 665                 670         


Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His 
        675                 680                 685             


Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu 
    690                 695                 700                 


Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr 
705                 710                 715                 720 


Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val 
                725                 730                 735     


Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly 
            740                 745                 750         


Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu 
        755                 760                 765             


Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser 
    770                 775                 780                 


Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln 
785                 790                 795                 800 


Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser 
                805                 810                 815     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr 
        835                 840                 845             


Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser 
    850                 855                 860                 


Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu 
865                 870                 875                 880 


Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro 
                885                 890                 895     


Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp 
            900                 905                 910         


Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn 
        915                 920                 925             


Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala 
    930                 935                 940                 


Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp 
945                 950                 955                 960 


Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys 
                965                 970                 975     


Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile 
            980                 985                 990         


Asn Trp Arg Cys Asp Asn Asp Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
        995                 1000                 1005             


Ala Gly  Cys Ser His Ser Cys  Ser Ser Thr Gln Phe  Lys Cys Asn 
    1010                 1015                 1020             


Ser Gly  Arg Cys Ile Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn 
    1025                 1030                 1035             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn 
    1040                 1045                 1050             


Gln Ala  Thr Arg Pro Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln 
    1055                 1060                 1065             


Cys Arg  Leu Asp Gly Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    1070                 1075                 1080             


Gly Asp  Thr Asp Cys Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu 
    1085                 1090                 1095             


Gly Val  Thr His Val Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys 
    1100                 1105                 1110             


Asp Ser  Ala Arg Cys Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp 
    1115                 1120                 1125             


Asn Asp  Cys Glu Asp Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu 
    1130                 1135                 1140             


Ala Cys  Arg Pro Pro Ser His  Pro Cys Ala Asn Asn  Thr Ser Val 
    1145                 1150                 1155             


Cys Leu  Pro Pro Asp Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly 
    1160                 1165                 1170             


Asp Gly  Ser Asp Glu Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn 
    1175                 1180                 1185             


Asn Gly  Gly Cys Ser His Asn  Cys Ser Val Ala Pro  Gly Glu Gly 
    1190                 1195                 1200             


Ile Val  Cys Ser Cys Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn 
    1205                 1210                 1215             


His Thr  Cys Gln Ile Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys 
    1220                 1225                 1230             


Ser Gln  Lys Cys Asp Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys 
    1235                 1240                 1245             


Tyr Glu  Gly Trp Val Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser 
    1250                 1255                 1260             


Leu Asp  Pro Phe Lys Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu 
    1265                 1270                 1275             


Ile Arg  Arg Ile Asp Leu His  Lys Gly Asp Tyr Ser  Val Leu Val 
    1280                 1285                 1290             


Pro Gly  Leu Arg Asn Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln 
    1295                 1300                 1305             


Ser Ala  Leu Tyr Trp Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg 
    1310                 1315                 1320             


Gly Lys  Leu Leu Asp Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val 
    1325                 1330                 1335             


Ile Gln  Tyr Gly Leu Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp 
    1340                 1345                 1350             


Ile Ala  Gly Asn Ile Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile 
    1355                 1360                 1365             


Glu Val  Ala Lys Leu Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala 
    1370                 1375                 1380             


Gly Asp  Ile Glu His Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp 
    1385                 1390                 1395             


Gly Ile  Leu Phe Trp Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile 
    1400                 1405                 1410             


Glu Ala  Ala Ser Met Ser Gly  Ala Gly Arg Arg Thr  Val His Arg 
    1415                 1420                 1425             


Glu Thr  Gly Ser Gly Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr 
    1430                 1435                 1440             


Leu Glu  Lys Arg Ile Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile 
    1445                 1450                 1455             


Tyr Ser  Ala Arg Tyr Asp Gly  Ser Gly His Met Glu  Val Leu Arg 
    1460                 1465                 1470             


Gly His  Glu Phe Leu Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly 
    1475                 1480                 1485             


Gly Glu  Val Tyr Trp Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys 
    1490                 1495                 1500             


Ala Asn  Lys Trp Thr Gly His  Asn Val Thr Val Val  Gln Arg Thr 
    1505                 1510                 1515             


Asn Thr  Gln Pro Phe Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln 
    1520                 1525                 1530             


Pro Met  Ala Pro Asn Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro 
    1535                 1540                 1545             


Cys Ser  His Leu Cys Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys 
    1550                 1555                 1560             


Ala Cys  Pro His Leu Met Lys  Leu His Lys Asp Asn  Thr Thr Cys 
    1565                 1570                 1575             


Tyr Glu  Phe Lys Lys Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile 
    1580                 1585                 1590             


Arg Gly  Val Asp Leu Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser 
    1595                 1600                 1605             


Phe Thr  Val Pro Asp Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp 
    1610                 1615                 1620             


Ala Arg  Glu Gln Arg Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala 
    1625                 1630                 1635             


Ile Lys  Arg Ala Phe Ile Asn  Gly Thr Gly Val Glu  Thr Val Val 
    1640                 1645                 1650             


Ser Ala  Asp Leu Pro Asn Ala  His Gly Leu Ala Val  Asp Trp Val 
    1655                 1660                 1665             


Ser Arg  Asn Leu Phe Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln 
    1670                 1675                 1680             


Ile Asn  Val Ala Arg Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val 
    1685                 1690                 1695             


Gln Gly  Leu Glu Gln Pro His  Gly Leu Val Val His  Pro Leu Arg 
    1700                 1705                 1710             


Gly Lys  Leu Tyr Trp Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn 
    1715                 1720                 1725             


Met Asp  Gly Ser Asn Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly 
    1730                 1735                 1740             


Pro Val  Gly Leu Ala Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp 
    1745                 1750                 1755             


Ile Ser  Ser Gly Asn His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly 
    1760                 1765                 1770             


Ser Gly  Leu Glu Val Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys 
    1775                 1780                 1785             


Ala Thr  Ala Leu Ala Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp 
    1790                 1795                 1800             


Gln Val  Ser Glu Lys Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser 
    1805                 1810                 1815             


Gly Ser  Val Val Leu Arg Asn  Ser Thr Thr Leu Val  Met His Met 
    1820                 1825                 1830             


Lys Val  Tyr Asp Glu Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn 
    1835                 1840                 1845             


Pro Cys  Ser Val Asn Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro 
    1850                 1855                 1860             


Thr Ser  Glu Thr Thr Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser 
    1865                 1870                 1875             


Leu Arg  Ser Gly Gln Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu 
    1880                 1885                 1890             


Leu Tyr  Ser Val His Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro 
    1895                 1900                 1905             


Asn Asp  Lys Ser Asp Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu 
    1910                 1915                 1920             


Ala Val  Gly Ile Asp Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp 
    1925                 1930                 1935             


Val Asp  Met Gly Leu Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln 
    1940                 1945                 1950             


Thr Trp  Arg Glu Asp Val Val  Thr Asn Gly Ile Gly  Arg Val Glu 
    1955                 1960                 1965             


Gly Ile  Ala Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp 
    1970                 1975                 1980             


Gln Gly  Phe Asp Val Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe 
    1985                 1990                 1995             


Arg Tyr  Val Val Ile Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile 
    2000                 2005                 2010             


Thr Val  His Pro Glu Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly 
    2015                 2020                 2025             


Gln Tyr  Pro Arg Ile Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg 
    2030                 2035                 2040             


Val Val  Leu Val Asn Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser 
    2045                 2050                 2055             


Val Asp  Tyr Gln Asp Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr 
    2060                 2065                 2070             


Asp Lys  Ile Glu Arg Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu 
    2075                 2080                 2085             


Val Val  Leu Ser Ser Asn Asn  Met Asp Met Phe Ser  Val Ser Val 
    2090                 2095                 2100             


Phe Glu  Asp Phe Ile Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly 
    2105                 2110                 2115             


Ser Ile  Lys Arg Gly Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro 
    2120                 2125                 2130             


Leu Arg  Thr Gly Ile Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe 
    2135                 2140                 2145             


Asn Arg  Asp Arg Gln Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn 
    2150                 2155                 2160             


Gly Gly  Cys Gln Gln Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg 
    2165                 2170                 2175             


Ala Cys  Ala Cys Ala His Gly  Met Leu Ala Glu Asp  Gly Ala Ser 
    2180                 2185                 2190             


Cys Arg  Glu Tyr Ala Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile 
    2195                 2200                 2205             


Leu Lys  Ser Ile His Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro 
    2210                 2215                 2220             


Val Gln  Pro Phe Glu Asp Pro  Glu His Met Lys Asn  Val Ile Ala 
    2225                 2230                 2235             


Leu Ala  Phe Asp Tyr Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn 
    2240                 2245                 2250             


Arg Ile  Phe Phe Ser Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile 
    2255                 2260                 2265             


Asn Asp  Asp Gly Ser Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly 
    2270                 2275                 2280             


Ser Val  Glu Gly Leu Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Trp Thr  Ser Tyr Thr Thr Ser  Thr Ile Thr Arg His  Thr Val Asp 
    2300                 2305                 2310             


Gln Thr  Arg Pro Gly Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met 
    2315                 2320                 2325             


Ser Gly  Asp Asp His Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln 
    2330                 2335                 2340             


Asn Leu  Met Phe Trp Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile 
    2345                 2350                 2355             


Met Arg  Ala Ala Leu Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu 
    2360                 2365                 2370             


Lys Asp  Ile Arg Thr Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala 
    2375                 2380                 2385             


Glu Lys  Leu Tyr Phe Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg 
    2390                 2395                 2400             


Cys Glu  Tyr Asp Gly Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu 
    2405                 2410                 2415             


Pro Val  His Pro Phe Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe 
    2420                 2425                 2430             


Trp Thr  Asp Trp Val Arg Arg  Ala Val Gln Arg Ala  Asn Lys His 
    2435                 2440                 2445             


Val Gly  Ser Asn Met Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln 
    2450                 2455                 2460             


Pro Met  Gly Ile Ile Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu 
    2465                 2470                 2475             


Leu Ser  Pro Cys Arg Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys 
    2480                 2485                 2490             


Leu Leu  Thr His Gln Gly His  Val Asn Cys Ser Cys  Arg Gly Gly 
    2495                 2500                 2505             


Arg Ile  Leu Gln Asp Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser 
    2510                 2515                 2520             


Cys Arg  Ala Gln Asp Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile 
    2525                 2530                 2535             


Asn Phe  Ser Leu Thr Cys Asp  Gly Val Pro His Cys  Lys Asp Lys 
    2540                 2545                 2550             


Ser Asp  Glu Lys Pro Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys 
    2555                 2560                 2565             


Thr Phe  Arg Gln Cys Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu 
    2570                 2575                 2580             


Trp Cys  Asn Gly Ala Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile 
    2585                 2590                 2595             


Pro Cys  Asn Lys Thr Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg 
    2600                 2605                 2610             


Asp Gly  Thr Cys Ile Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val 
    2615                 2620                 2625             


Asp Cys  Glu Asp Ala Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp 
    2630                 2635                 2640             


Cys Ser  Ser Tyr Phe Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln 
    2645                 2650                 2655             


Pro Cys  Glu Arg Thr Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys 
    2660                 2665                 2670             


Asp Gly  Ala Asn Asp Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys 
    2675                 2680                 2685             


Pro Gly  Val Lys Arg Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys 
    2690                 2695                 2700             


Pro Ser  Gly Arg Cys Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu 
    2705                 2710                 2715             


Asp Asp  Cys Glu His Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe 
    2720                 2725                 2730             


Cys Ser  Glu Ala Gln Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser 
    2735                 2740                 2745             


Lys Gln  Trp Leu Cys Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser 
    2750                 2755                 2760             


Asp Glu  Ala Ala His Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser 
    2765                 2770                 2775             


Phe Ser  Cys Pro Gly Thr His  Val Cys Val Pro Glu  Arg Trp Leu 
    2780                 2785                 2790             


Cys Asp  Gly Asp Lys Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile 
    2795                 2800                 2805             


Ala Ala  Gly Cys Leu Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe 
    2810                 2815                 2820             


Met Cys  Gln Asn Arg Gln Cys  Ile Pro Lys His Phe  Val Cys Asp 
    2825                 2830                 2835             


His Asp  Arg Asp Cys Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys 
    2840                 2845                 2850             


Glu Tyr  Pro Thr Cys Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly 
    2855                 2860                 2865             


Arg Cys  Leu Ser Ser Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp 
    2870                 2875                 2880             


Cys His  Asp Gln Ser Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr 
    2885                 2890                 2895             


Ser Gln  Glu His Lys Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser 
    2900                 2905                 2910             


Ser Gly  Arg Cys Val Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp 
    2915                 2920                 2925             


Asp Cys  Gly Asp Ser Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu 
    2930                 2935                 2940             


Cys Leu  Ser Arg Lys Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp 
    2945                 2950                 2955             


Leu Lys  Ile Gly Phe Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu 
    2960                 2965                 2970             


Lys Asp  Asp Gly Arg Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr 
    2975                 2980                 2985             


Thr Phe  Pro Cys Ser Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr 
    2990                 2995                 3000             


Lys Cys  Leu Cys Val Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro 
    3005                 3010                 3015             


His Ser  Cys Lys Ala Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe 
    3020                 3025                 3030             


Ala Asn  Arg Tyr Tyr Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn 
    3035                 3040                 3045             


Tyr Thr  Leu Leu Lys Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp 
    3050                 3055                 3060             


Phe Asp  Tyr Arg Glu Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr 
    3065                 3070                 3075             


Gln Gly  Ser Met Ile Arg Arg  Met His Leu Asn Gly  Ser Asn Val 
    3080                 3085                 3090             


Gln Val  Leu His Arg Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala 
    3095                 3100                 3105             


Val Asp  Trp Val Gly Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg 
    3110                 3115                 3120             


Asp Thr  Ile Glu Val Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val 
    3125                 3130                 3135             


Leu Val  Ser Ser Gly Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp 
    3140                 3145                 3150             


Val Gln  Asn Gly Tyr Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser 
    3155                 3160                 3165             


Leu Ile  Gly Arg Ile Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile 
    3170                 3175                 3180             


Val Asp  Thr Lys Ile Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr 
    3185                 3190                 3195             


Val Thr  Glu Arg Ile Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile 
    3200                 3205                 3210             


Glu Phe  Ala Ser Leu Asp Gly  Ser Asn Arg His Val  Val Leu Ser 
    3215                 3220                 3225             


Gln Asp  Ile Pro His Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr 
    3230                 3235                 3240             


Val Tyr  Trp Thr Asp Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His 
    3245                 3250                 3255             


Lys Thr  Thr Gly Thr Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His 
    3260                 3265                 3270             


Arg Pro  Met Asp Leu His Val  Phe His Ala Leu Arg  Gln Pro Asp 
    3275                 3280                 3285             


Val Pro  Asn His Pro Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn 
    3290                 3295                 3300             


Leu Cys  Leu Leu Ser Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro 
    3305                 3310                 3315             


Thr Asn  Phe Tyr Leu Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn 
    3320                 3325                 3330             


Cys Thr  Ala Ser Gln Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro 
    3335                 3340                 3345             


Phe Trp  Trp Lys Cys Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser 
    3350                 3355                 3360             


Asp Glu  Pro Pro Asp Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln 
    3365                 3370                 3375             


Phe Gln  Cys Ser Thr Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys 
    3380                 3385                 3390             


Asp Gly  Asp Asn Asp Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys 
    3395                 3400                 3405             


Asp Ile  His Val Cys Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr 
    3410                 3415                 3420             


Asn Arg  Cys Ile Pro Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn 
    3425                 3430                 3435             


Cys Gly  Asp Gly Glu Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys 
    3440                 3445                 3450             


Ala Pro  Asn Gln Phe Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro 
    3455                 3460                 3465             


Arg Val  Trp Val Cys Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser 
    3470                 3475                 3480             


Asp Glu  Pro Ala Asn Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu 
    3485                 3490                 3495             


Phe Arg  Cys Lys Asp Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys 
    3500                 3505                 3510             


Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys 
    3515                 3520                 3525             


Glu Glu  Cys Asp Glu Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys 
    3530                 3535                 3540             


Lys Asn  Asn Arg Cys Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp 
    3545                 3550                 3555             


Asn Asp  Cys Gly Asp Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg 
    3560                 3565                 3570             


Pro Cys  Ser Glu Ser Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile 
    3575                 3580                 3585             


Ala Gly  Arg Trp Lys Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly 
    3590                 3595                 3600             


Ser Asp  Glu Lys Asp Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe 
    3605                 3610                 3615             


Gln Cys  Lys Ser Gly His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    3620                 3625                 3630             


Ala Asp  Ala Asp Cys Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly 
    3635                 3640                 3645             


Thr Gly  Val Arg Thr Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn 
    3650                 3655                 3660             


Thr Leu  Cys Lys Pro Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp 
    3665                 3670                 3675             


Cys Gly  Asp Asn Ser Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe 
    3680                 3685                 3690             


Val Cys  Pro Pro Asn Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val 
    3695                 3700                 3705             


Cys Leu  Trp Ile Gly Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly 
    3710                 3715                 3720             


Asp Gly  Thr Asp Glu Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr 
    3725                 3730                 3735             


Thr His  Cys Lys Asp Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg 
    3740                 3745                 3750             


Cys Leu  Ser Ser Ser Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly 
    3755                 3760                 3765             


Asp Gly  Ser Asp Glu Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr 
    3770                 3775                 3780             


Ser Cys  Ala Thr Asn Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys 
    3785                 3790                 3795             


Val Arg  Thr Glu Lys Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe 
    3800                 3805                 3810             


His Thr  Val Pro Gly Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys 
    3815                 3820                 3825             


Leu Arg  Phe Gly Thr Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly 
    3830                 3835                 3840             


Gly His  Leu Cys Ser Cys Ala  Arg Asn Phe Met Lys  Thr His Asn 
    3845                 3850                 3855             


Thr Cys  Lys Ala Glu Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala 
    3860                 3865                 3870             


Asp Asp  Asn Glu Ile Arg Ser  Leu Phe Pro Gly His  Pro His Ser 
    3875                 3880                 3885             


Ala Tyr  Glu Gln Ala Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp 
    3890                 3895                 3900             


Ala Met  Asp Val His Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn 
    3905                 3910                 3915             


Trp His  Thr Gly Thr Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala 
    3920                 3925                 3930             


Pro Pro  Thr Thr Ser Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly 
    3935                 3940                 3945             


Val Thr  His Leu Asn Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile 
    3950                 3955                 3960             


Ala Ile  Asp Trp Val Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly 
    3965                 3970                 3975             


Arg Asp  Val Ile Glu Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys 
    3980                 3985                 3990             


Thr Leu  Ile Ser Gly Met Ile  Asp Glu Pro His Ala  Ile Val Val 
    3995                 4000                 4005             


Asp Pro  Leu Arg Gly Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His 
    4010                 4015                 4020             


Pro Lys  Ile Glu Thr Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr 
    4025                 4030                 4035             


Leu Val  Gln Asp Asn Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp 
    4040                 4045                 4050             


Tyr His  Asn Glu Arg Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val 
    4055                 4060                 4065             


Ile Gly  Ser Ile Arg Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala 
    4070                 4075                 4080             


Asp Ser  Lys Arg Gly Leu Ser  His Pro Phe Ser Ile  Asp Val Phe 
    4085                 4090                 4095             


Glu Asp  Tyr Ile Tyr Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe 
    4100                 4105                 4110             


Lys Ile  His Lys Phe Gly His  Ser Pro Leu Val Asn  Leu Thr Gly 
    4115                 4120                 4125             


Gly Leu  Ser His Ala Ser Asp  Val Val Leu Tyr His  Gln His Lys 
    4130                 4135                 4140             


Gln Pro  Glu Val Thr Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp 
    4145                 4150                 4155             


Leu Cys  Leu Leu Ser Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn 
    4160                 4165                 4170             


Gly Lys  Arg Leu Asp Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro 
    4175                 4180                 4185             


Thr Pro  Pro Pro Asp Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln 
    4190                 4195                 4200             


Cys Phe  Asn Gly Gly Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro 
    4205                 4210                 4215             


Lys Cys  Arg Cys Gln Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu 
    4220                 4225                 4230             


Asp Gln  Cys Trp Glu His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala 
    4235                 4240                 4245             


Ser Pro  Ser Gly Met Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr 
    4250                 4255                 4260             


Gly Pro  Lys Cys Thr Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn 
    4265                 4270                 4275             


Asn Ser  Thr Cys Thr Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg 
    4280                 4285                 4290             


Cys Leu  Pro Gly Phe Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys 
    4295                 4300                 4305             


Ser Gly  Tyr Cys Glu Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp 
    4310                 4315                 4320             


Gly Ser  Arg Gln Cys Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg 
    4325                 4330                 4335             


Cys Glu  Val Asn Lys Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val 
    4340                 4345                 4350             


Val Asn  Lys Gln Ser Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly 
    4355                 4360                 4365             


Arg Val  Ala Pro Ser Cys Leu  Thr Cys Val Gly His  Cys Ser Asn 
    4370                 4375                 4380             


Gly Gly  Ser Cys Thr Met Asn  Ser Lys Met Met Pro  Glu Cys Gln 
    4385                 4390                 4395             


Cys Pro  Pro His Met Thr Gly  Pro Arg Cys Glu Glu  His Val Phe 
    4400                 4405                 4410             


Ser Gln  Gln Gln Pro Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu 
    4415                 4420                 4425             


Leu Leu  Leu Leu Leu Leu Val  Leu Val Ala Gly Val  Val Phe Trp 
    4430                 4435                 4440             


Tyr Lys  Arg Arg Val Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg 
    4445                 4450                 4455             


Met Thr  Asn Gly Ala Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr 
    4460                 4465                 4470             


Lys Met  Tyr Glu Gly Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu 
    4475                 4480                 4485             


Asp Ala  Asp Phe Ala Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr 
    4490                 4495                 4500             


Asn Pro  Val Tyr Ala Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg 
    4505                 4510                 4515             


His Ser  Leu Ala Ser Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg 
    4520                 4525                 4530             


Gly Pro  Glu Asp Glu Ile Gly  Asp Pro Leu Ala 
    4535                 4540                 


<210>  61
<211>  100
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD 91 intracellular domain

<400>  61

Lys Arg Arg Val Gln Gly Ala Lys Gly Phe Gln His Gln Arg Met Thr 
1               5                   10                  15      


Asn Gly Ala Met Asn Val Glu Ile Gly Asn Pro Thr Tyr Lys Met Tyr 
            20                  25                  30          


Glu Gly Gly Glu Pro Asp Asp Val Gly Gly Leu Leu Asp Ala Asp Phe 
        35                  40                  45              


Ala Leu Asp Pro Asp Lys Pro Thr Asn Phe Thr Asn Pro Val Tyr Ala 
    50                  55                  60                  


Thr Leu Tyr Met Gly Gly His Gly Ser Arg His Ser Leu Ala Ser Thr 
65                  70                  75                  80  


Asp Glu Lys Arg Glu Leu Leu Gly Arg Gly Pro Glu Asp Glu Ile Gly 
                85                  90                  95      


Asp Pro Leu Ala 
            100 


<210>  62
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD 91 transmembrane domain

<400>  62

His Ile Ala Ser Ile Leu Ile Pro Leu Leu Leu Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Val Ala Gly Val Val Phe Trp Tyr 
            20                  25  


<210>  63
<211>  1722
<212>  PRT
<213>  artificial sequence

<220>
<223>  DEC-205 full length

<400>  63

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Gly Pro  Asp Tyr Thr 
    1655                 1660                 1665             


Ala Ile  Ala Ile Ile Val Ala  Thr Leu Ser Ile Leu  Val Leu Met 
    1670                 1675                 1680             


Gly Gly  Leu Ile Trp Phe Leu  Phe Gln Arg His Arg  Leu His Leu 
    1685                 1690                 1695             


Ala Gly  Phe Ser Ser Val Arg  Tyr Ala Gln Gly Val  Asn Glu Asp 
    1700                 1705                 1710             


Glu Ile  Met Leu Pro Ser Phe  His Asp 
    1715                 1720         


<210>  64
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  DEC-205 intracellular domain

<400>  64

Gln Arg His Arg Leu His Leu Ala Gly Phe Ser Ser Val Arg Tyr Ala 
1               5                   10                  15      


Gln Gly Val Asn Glu Asp Glu Ile Met Leu Pro Ser Phe His Asp 
            20                  25                  30      


<210>  65
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  DEC-205 transmembrane domain

<400>  65

Tyr Thr Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu Val Leu 
1               5                   10                  15      


Met Gly Gly Leu Ile Trp Phe Leu Phe 
            20                  25  


<210>  66
<211>  404
<212>  PRT
<213>  artificial sequence

<220>
<223>  DC-SIGN full length

<400>  66

Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Thr Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Thr Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
                85                  90                  95      


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly 
            100                 105                 110         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
        115                 120                 125             


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
    130                 135                 140                 


Glu Ile Tyr Gln Glu Leu Thr Trp Leu Lys Ala Ala Val Gly Glu Leu 
145                 150                 155                 160 


Pro Glu Lys Ser Lys Met Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu 
                165                 170                 175     


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile 
            180                 185                 190         


Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        195                 200                 205             


Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    210                 215                 220                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln 
225                 230                 235                 240 


Glu Leu Thr Gln Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys 
                245                 250                 255     


Pro Trp Glu Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            260                 265                 270         


Ser Gln Arg Asn Trp His Asp Ser Ile Thr Ala Cys Lys Glu Val Gly 
        275                 280                 285             


Ala Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln Asn Phe Leu Gln 
    290                 295                 300                 


Leu Gln Ser Ser Arg Ser Asn Arg Phe Thr Trp Met Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Leu 
                325                 330                 335     


Pro Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro Asn Asn Val Gly 
            340                 345                 350         


Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys 
        355                 360                 365             


Cys Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser Ala Ala Ser Cys 
    370                 375                 380                 


Ser Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro Ala Thr Pro Asn 
385                 390                 395                 400 


Pro Pro Pro Ala 
                


<210>  67
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  DC-SIGN intracellular domain

<400>  67

Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Thr Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys 
        35          


<210>  68
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  DC-SIGN transmembrane domain

<400>  68

Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu Ser Phe Thr Leu Leu 
1               5                   10                  15      


Ala Gly Leu Leu Val 
            20      


<210>  69
<211>  45
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD8 hinge

<400>  69

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  70
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD28 hinge

<400>  70

Val Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn 
1               5                   10                  15      


Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys 
            20                  25                  30          


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40              


<210>  71
<211>  35
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG Fc hinge

<400>  71

Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly Arg Val Thr Val Ser Ser 
1               5                   10                  15      


Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            20                  25                  30          


Asp Pro Lys 
        35  


<210>  72
<211>  266
<212>  PRT
<213>  artificial sequence

<220>
<223>  1412 scFV

<400>  72

Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr 
65                  70                  75                  80  


Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met Asp Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            260                 265     


<210>  73
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  1412 heavy chain variable domain

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  74
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  1412 light chain variable domain

<400>  74

Val Met Asp Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
            20                  25                  30          


Tyr Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr 
                85                  90                  95      


Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  75
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2.103 scFV

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Val Leu Trp Ile Gly Glu Leu Ser Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu Tyr Lys Ala Ser 
            180                 185                 190         


Gly Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Tyr Ser Trp Thr Phe Gly His 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  76
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2.103 heavy chain variable domain

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Val Leu Trp Ile Gly Glu Leu Ser Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  77
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2.103 light chain variable domain

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Lys Ala Ser Gly Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  78
<211>  261
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.157 scFV

<400>  78

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Arg Thr Arg Pro Tyr Ile Thr Val 
                85                  90                  95      


Arg Lys Met Gly Gly Thr Met Val Arg Gly Val Met Gly Thr Leu Thr 
            100                 105                 110         


Thr Gly Ala Arg Glu Pro Trp Ser Pro Ser Pro Gln Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Val Ser Ala Ser Ala Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Gly Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Arg Thr Val Leu His His Leu Ser Ser Ser Ser 
                245                 250                 255     


Arg His Leu Met Ser 
            260     


<210>  79
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.157 heavy chain variable domain

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Arg Thr Arg Pro Tyr Ile Thr Val 
                85                  90                  95      


Arg Lys Met Gly Gly Thr Met Val Arg Gly Val Met Gly Thr Leu Thr 
            100                 105                 110         


Thr Gly Ala Arg Glu Pro Trp Ser Pro Ser Pro Gln 
        115                 120                 


<210>  80
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.157 light chain variable domain

<400>  80

Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Ala Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Leu His His 
            100                 105                 110         


Leu Ser Ser Ser Ser Arg His Leu Met Ser 
        115                 120         


<210>  81
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.77 scFV

<400>  81

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Gly Tyr Tyr Gly Ser Gly Ser Tyr Gly Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Val Ser Gly Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Gly Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr 
                245             


<210>  82
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.77 heavy chain variable domain

<400>  82

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Gly Tyr Tyr Gly Ser Gly Ser Tyr Gly Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  83
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.77 light chain variable domain

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Gly Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  84
<211>  247
<212>  PRT
<213>  artificial sequence

<220>
<223>  4D11 scFV

<400>  84

Pro Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser 
1               5                   10                  15      


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser 
            20                  25                  30          


Pro Gly Tyr Tyr Gly Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Ile Gly Ser Ile Tyr Lys Ser Gly Ser Thr Tyr His Asn Pro 
    50                  55                  60                  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Pro Val Val Arg Tyr Phe Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Arg Thr 
                245         


<210>  85
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  4D11 heavy chain variable domain

<400>  85

Pro Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser 
1               5                   10                  15      


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser 
            20                  25                  30          


Pro Gly Tyr Tyr Gly Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Ile Gly Ser Ile Tyr Lys Ser Gly Ser Thr Tyr His Asn Pro 
    50                  55                  60                  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Pro Val Val Arg Tyr Phe Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  86
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  4D11 light chain variable domain

<400>  86

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             


<210>  87
<211>  242
<212>  PRT
<213>  artificial sequence

<220>
<223>  A40C scFV

<400>  87

Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp 
            20                  25                  30          


Tyr Tyr Val His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Arg Ile Asp Pro Glu Asp Gly Asp Ser Lys Tyr Ala Pro Lys 
    50                  55                  60                  


Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Val 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Thr Thr Ser Tyr Tyr Val Gly Thr Tyr Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Leu Trp Phe Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg 
    210                 215                 220                 


Thr Phe Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg Thr 
        


<210>  88
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  A40C heavy chain variable domain

<400>  88

Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp 
            20                  25                  30          


Tyr Tyr Val His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Arg Ile Asp Pro Glu Asp Gly Asp Ser Lys Tyr Ala Pro Lys 
    50                  55                  60                  


Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Val 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Thr Thr Ser Tyr Tyr Val Gly Thr Tyr Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  89
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  A40C light chain variable domain

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Leu Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Thr Phe Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             


<210>  90
<211>  250
<212>  PRT
<213>  artificial sequence

<220>
<223>  119 scFV

<400>  90

Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser 
            20                  25                  30          


Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Asp Leu 
        35                  40                  45              


Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Arg Asp Tyr 
    50                  55                  60                  


Val Gly Ser Val Lys Ser Arg Ile Ile Ile Asn Pro Asp Thr Ser Asn 
65                  70                  75                  80  


Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      


Ile Tyr Tyr Cys Thr Arg Ala Gln Trp Leu Gly Gly Asp Tyr Pro Tyr 
            100                 105                 110         


Tyr Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
145                 150                 155                 160 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
                165                 170                 175     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
            180                 185                 190         


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
    210                 215                 220                 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Thr Phe Gly 
225                 230                 235                 240 


Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
                245                 250 


<210>  91
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  119 heavy chain variable domain

<400>  91

Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser 
            20                  25                  30          


Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Asp Leu 
        35                  40                  45              


Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Arg Asp Tyr 
    50                  55                  60                  


Val Gly Ser Val Lys Ser Arg Ile Ile Ile Asn Pro Asp Thr Ser Asn 
65                  70                  75                  80  


Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      


Ile Tyr Tyr Cys Thr Arg Ala Gln Trp Leu Gly Gly Asp Tyr Pro Tyr 
            100                 105                 110         


Tyr Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  92
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  119 light chain variable domain

<400>  92

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Thr Phe Gly 
                85                  90                  95      


Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
            100                 105     


<210>  93
<211>  302
<212>  PRT
<213>  artificial sequence

<220>
<223>  40L.28.40L.40L (CD40L signal peptide-CD28 intracellular 
       region-CD40L transmembrane region - CD40L cytoplasmic domain)

<400>  93

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            20                  25                  30          


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        35                  40                  45              


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ile 
    50                  55                  60                  


Phe Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly Ser 
65                  70                  75                  80  


Ala Leu Phe Ala Val Tyr Leu His Arg Arg Leu Asp Lys Ile Glu Asp 
                85                  90                  95      


Glu Arg Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg 
            100                 105                 110         


Cys Asn Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile 
        115                 120                 125             


Lys Ser Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu 
    130                 135                 140                 


Glu Thr Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn 
145                 150                 155                 160 


Pro Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr 
                165                 170                 175     


Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn 
            180                 185                 190         


Leu Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly 
        195                 200                 205             


Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala 
    210                 215                 220                 


Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly 
225                 230                 235                 240 


Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala 
                245                 250                 255     


Lys Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu 
            260                 265                 270         


Gln Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val 
        275                 280                 285             


Ser His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
    290                 295                 300         


<210>  94
<211>  440
<212>  PRT
<213>  artificial sequence

<220>
<223>  1412-T4-CD40L (anti-CD28 scFv (1412)- T4 fibritin trimerization 
       motif-CD40L extracellular region)

<400>  94

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met Asp 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Tyr Ile Pro Glu 
            260                 265                 270         


Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val 
        275                 280                 285             


Leu Leu Ser Thr Phe Leu Gly Asp Gln Asn Pro Gln Ile Ala Ala His 
    290                 295                 300                 


Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala 
305                 310                 315                 320 


Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn 
                325                 330                 335     


Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala 
            340                 345                 350         


Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe 
        355                 360                 365             


Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu 
    370                 375                 380                 


Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln 
385                 390                 395                 400 


Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val 
                405                 410                 415     


Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe 
            420                 425                 430         


Thr Ser Phe Gly Leu Leu Lys Leu 
        435                 440 


<210>  95
<211>  521
<212>  PRT
<213>  artificial sequence

<220>
<223>  1412-F2.103 (Anti-CD28/anti-CD40 bispecific Ab)

<400>  95

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met Asp 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Thr Tyr 
    290                 295                 300                 


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
305                 310                 315                 320 


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Thr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Asp Arg Val Leu Trp Ile Gly Glu Leu Ser Tyr Tyr Gly Met 
    370                 375                 380                 


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
                405                 410                 415     


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
            420                 425                 430         


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp Leu Ala Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu Tyr Lys Ala Ser 
    450                 455                 460                 


Gly Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro Asp Asp Phe Ala 
                485                 490                 495     


Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Tyr Ser Trp Thr Phe Gly His 
            500                 505                 510         


Gly Thr Lys Val Glu Ile Lys Arg Thr 
        515                 520     


<210>  96
<211>  533
<212>  PRT
<213>  artificial sequence

<220>
<223>  1412-F5.157 (Anti-CD28/anti-CD40 bispecific Ab)

<400>  96

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met Asp 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Pro Arg Thr Arg Pro Tyr Ile Thr Val 
        355                 360                 365             


Arg Lys Met Gly Gly Thr Met Val Arg Gly Val Met Gly Thr Leu Thr 
    370                 375                 380                 


Thr Gly Ala Arg Glu Pro Trp Ser Pro Ser Pro Gln Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
                405                 410                 415     


Ser Pro Ser Ser Val Ser Ala Ser Ala Gly Asp Arg Val Thr Ile Thr 
            420                 425                 430         


Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln 
        435                 440                 445             


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Gly Ser Ser Leu 
    450                 455                 460                 


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp 
465                 470                 475                 480 


Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
                485                 490                 495     


Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg Thr Phe Gly Gln Gly Thr 
            500                 505                 510         


Lys Val Glu Ile Lys Arg Thr Val Leu His His Leu Ser Ser Ser Ser 
        515                 520                 525             


Arg His Leu Met Ser 
    530             


<210>  97
<211>  520
<212>  PRT
<213>  artificial sequence

<220>
<223>  1412-F5.77 (Anti-CD28/anti-CD40 bispecific Ab)

<400>  97

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met Asp 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
    290                 295                 300                 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Lys Asp Gly Gly Tyr Tyr Gly Ser Gly Ser Tyr Gly Tyr Phe Asp 
    370                 375                 380                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                405                 410                 415     


Gln Ser Pro Ser Ser Val Ser Gly Ser Val Gly Asp Arg Val Thr Ile 
            420                 425                 430         


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Gly Ser Ser 
    450                 455                 460                 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly Thr 
465                 470                 475                 480 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
                485                 490                 495     


Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg Thr Phe Gly Gln Gly 
            500                 505                 510         


Thr Lys Val Glu Ile Lys Arg Thr 
        515                 520 


<210>  98
<211>  385
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2.103.CD28: (Anti-CD40 scFv-CD28 membrane chimeric fusion 
       protein)

<400>  98

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Thr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Asp Arg Val Leu Trp Ile Gly Glu Leu 
        115                 120                 125             


Ser Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
                165                 170                 175     


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn 
            180                 185                 190         


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        195                 200                 205             


Leu Tyr Lys Ala Ser Gly Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln 
225                 230                 235                 240 


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Tyr Ser 
                245                 250                 255     


Trp Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr Ala Ser 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
305                 310                 315                 320 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                325                 330                 335     


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            340                 345                 350         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        355                 360                 365             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    370                 375                 380                 


Ser 
385 


<210>  99
<211>  397
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.157.CD28: (Anti-CD40 scFv-CD28 membrane chimeric fusion 
       protein)

<400>  99

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ala Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Arg Thr Arg 
            100                 105                 110         


Pro Tyr Ile Thr Val Arg Lys Met Gly Gly Thr Met Val Arg Gly Val 
        115                 120                 125             


Met Gly Thr Leu Thr Thr Gly Ala Arg Glu Pro Trp Ser Pro Ser Pro 
    130                 135                 140                 


Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Ala Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Ala Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Leu His His 
            260                 265                 270         


Leu Ser Ser Ser Ser Arg His Leu Met Ser Ala Ser Thr Thr Thr Pro 
        275                 280                 285             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    290                 295                 300                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
305                 310                 315                 320 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
                325                 330                 335     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            340                 345                 350         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        355                 360                 365             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    370                 375                 380                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
385                 390                 395         


<210>  100
<211>  384
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.77.CD28 (Anti-CD40 scFv-CD28 membrane chimeric fusion 
       protein):

<400>  100

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asp Gly Gly Tyr Tyr Gly Ser Gly Ser 
        115                 120                 125             


Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Gly Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            180                 185                 190         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ala Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Ala Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
305                 310                 315                 320 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                325                 330                 335     


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            340                 345                 350         


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
        355                 360                 365             


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375                 380                 


<210>  101
<211>  379
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2.103.BB (Anti-CD40 scFv-4-1BB membrane chimeric fusion 
       protein):

<400>  101

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Thr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Asp Arg Val Leu Trp Ile Gly Glu Leu 
        115                 120                 125             


Ser Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
                165                 170                 175     


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn 
            180                 185                 190         


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        195                 200                 205             


Leu Tyr Lys Ala Ser Gly Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln 
225                 230                 235                 240 


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Tyr Ser 
                245                 250                 255     


Trp Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 


<210>  102
<211>  391
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.157.BB(Anti-CD40 scFv-4-1BB membrane chimeric fusion protein)

<400>  102

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ala Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Arg Thr Arg 
            100                 105                 110         


Pro Tyr Ile Thr Val Arg Lys Met Gly Gly Thr Met Val Arg Gly Val 
        115                 120                 125             


Met Gly Thr Leu Thr Thr Gly Ala Arg Glu Pro Trp Ser Pro Ser Pro 
    130                 135                 140                 


Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Ala Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Ala Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Leu His His 
            260                 265                 270         


Leu Ser Ser Ser Ser Arg His Leu Met Ser Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu 
385                 390     


<210>  103
<211>  378
<212>  PRT
<213>  artificial sequence

<220>
<223>  F5.77.BB(Anti-CD40 scFv-4-1BB membrane chimeric fusion protein)

<400>  103

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asp Gly Gly Tyr Tyr Gly Ser Gly Ser 
        115                 120                 125             


Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Gly Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            180                 185                 190         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ala Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ser Phe Pro Arg 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375             


<210>  104
<211>  382
<212>  PRT
<213>  artificial sequence

<220>
<223>  4D11.CD28

<400>  104

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Pro Gly Tyr Tyr Gly Gly Trp Ile Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Lys Ser Gly Ser Thr 
65                  70                  75                  80  


Tyr His Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Thr Arg Pro Val Val Arg Tyr Phe Gly Trp 
        115                 120                 125             


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Ala Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375                 380         


<210>  105
<211>  377
<212>  PRT
<213>  artificial sequence

<220>
<223>  A40C.CD28

<400>  105

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Lys Asp Tyr Tyr Val His Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Glu Asp Gly Asp Ser Lys 
65                  70                  75                  80  


Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Ser Tyr Tyr Val Gly Thr Tyr Gly Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Leu Trp Phe Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Arg Thr Phe Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Arg Thr Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375         


<210>  106
<211>  385
<212>  PRT
<213>  artificial sequence

<220>
<223>  119.CD28

<400>  106

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Ser Arg Asp Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp 
65                  70                  75                  80  


Tyr Arg Asp Tyr Val Gly Ser Val Lys Ser Arg Ile Ile Ile Asn Pro 
                85                  90                  95      


Asp Thr Ser Asn Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Ala Ile Tyr Tyr Cys Thr Arg Ala Gln Trp Leu Gly Gly 
        115                 120                 125             


Asp Tyr Pro Tyr Tyr Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Thr 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
                165                 170                 175     


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
            180                 185                 190         


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        195                 200                 205             


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
225                 230                 235                 240 


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
                245                 250                 255     


Asn Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Ala Ser 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
305                 310                 315                 320 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                325                 330                 335     


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            340                 345                 350         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        355                 360                 365             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    370                 375                 380                 


Ser 
385 


<210>  107
<211>  489
<212>  PRT
<213>  artificial sequence

<220>
<223>  4D5.BBZ (Her2 CAR)

<400>  107

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
                165                 170                 175     


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  108
<211>  486
<212>  PRT
<213>  artificial sequence

<220>
<223>  FMC63.BBZ (CD19 CAR)

<400>  108

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  109
<211>  488
<212>  PRT
<213>  artificial sequence

<220>
<223>  ss1.BBZ (mesothelin CAR)

<400>  109

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
            20                  25                  30          


Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His 
    50                  55                  60                  


Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala 
65                  70                  75                  80  


Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Asp Ile Glu 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val 
                165                 170                 175     


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr 
            180                 185                 190         


Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
        195                 200                 205             


Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Tyr Gly Ala 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Ala Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  110
<211>  461
<212>  PRT
<213>  artificial sequence

<220>
<223>  J591.BBZ (PSMA CAR)

<400>  110

Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
1               5                   10                  15      


Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr Ala Val Asp Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
        35                  40                  45              


Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Glu Asp Leu 
65                  70                  75                  80  


Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly 
                85                  90                  95      


Ala Gly Thr Met Leu Asp Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
        115                 120                 125             


Glu Leu Val Lys Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Thr Ser 
    130                 135                 140                 


Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ser His 
145                 150                 155                 160 


Gly Lys Ser Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly 
                165                 170                 175     


Thr Thr Tyr Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp 
            180                 185                 190         


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu 
        195                 200                 205             


Asp Ser Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Ser Gly Thr Thr 
225                 230                 235                 240 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
                245                 250                 255     


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
            260                 265                 270         


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
        275                 280                 285             


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
    290                 295                 300                 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
305                 310                 315                 320 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                325                 330                 335     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
385                 390                 395                 400 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                405                 410                 415     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            420                 425                 430         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        435                 440                 445             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460     


<210>  111
<211>  532
<212>  PRT
<213>  artificial sequence

<220>
<223>  c-Met CAR

<400>  111

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Gly Ile Asn Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Lys Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Met Gly Trp Ile Ser Ala Ser Asn Gly Asn Thr Tyr Tyr 
        195                 200                 205             


Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr 
    210                 215                 220                 


Ser Ser Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Val Tyr Ala Asp Tyr Ala Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ala Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             


Leu Pro Pro Arg 
    530         


<210>  112
<211>  483
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA CAR

<400>  112

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Ala Leu Ser Asn His Gly Met Ser Trp Val Arg Arg Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Gly Ile Val Tyr Ser Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ser Ala His Gly Gly Glu Ser Asp Val Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Arg Ala Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  113
<211>  364
<212>  PRT
<213>  artificial sequence

<220>
<223>  FHVH33.BBZ (BCMA CAR)

<400>  113

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Asp Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Glu Gly Thr Gly Ala Asn Ser Ser Leu 
        115                 120                 125             


Ala Asp Tyr Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
    130                 135                 140                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
145                 150                 155                 160 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                165                 170                 175     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            180                 185                 190         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        195                 200                 205             


Leu Tyr Cys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    210                 215                 220                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
225                 230                 235                 240 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 


<210>  114
<211>  488
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA338.BBZ (BCMA CAR)

<400>  114

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu His 
        35                  40                  45              


Thr Phe Ser Ser His Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Ser Val Ala Val Ile Gly Trp Arg Asp Ile Ser Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Lys Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Arg Arg Ile Asp Ala Ala Asp Phe Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Met 
                165                 170                 175     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
            180                 185                 190         


Ile Ser Leu Ser Pro Thr Leu Ala Tyr Tyr Ala Glu Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Val Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
225                 230                 235                 240 


Asp Arg Lys Ser Val Met Ser Ile Arg Pro Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  115
<211>  486
<212>  PRT
<213>  artificial sequence

<220>
<223>  G33.BBZ (GPC3 CAR)

<400>  115

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu 
            20                  25                  30          


Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His 
    50                  55                  60                  


Gly Leu Lys Trp Ile Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala 
65                  70                  75                  80  


Tyr Ser Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu 
145                 150                 155                 160 


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
                165                 170                 175     


Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
            180                 185                 190         


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
        195                 200                 205             


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
225                 230                 235                 240 


Val Tyr Phe Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  116
<211>  889
<212>  PRT
<213>  artificial sequence

<220>
<223>  IL13(EQ).BBZ (IL13ra2 car)

<400>  116

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg 
            20                  25                  30          


Tyr Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro 
        35                  40                  45              


Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met 
    50                  55                  60                  


Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala 
65                  70                  75                  80  


Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val 
                85                  90                  95      


Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu 
            100                 105                 110         


Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe 
        115                 120                 125             


Arg Glu Gly Arg Phe Asn Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    130                 135                 140                 


Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro 
145                 150                 155                 160 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                165                 170                 175     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            180                 185                 190         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        195                 200                 205             


Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    210                 215                 220                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
225                 230                 235                 240 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                245                 250                 255     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            260                 265                 270         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        275                 280                 285             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    290                 295                 300                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
305                 310                 315                 320 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                325                 330                 335     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Ala Leu Ile Val 
        355                 360                 365             


Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe 
    370                 375                 380                 


Phe Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
385                 390                 395                 400 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                405                 410                 415     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Gly Gly Arg Val 
            420                 425                 430         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        435                 440                 445             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    450                 455                 460                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
465                 470                 475                 480 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                485                 490                 495     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            500                 505                 510         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        515                 520                 525             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu 
    530                 535                 540                 


Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
545                 550                 555                 560 


Glu Asn Pro Gly Pro Arg Met Pro Pro Pro Arg Leu Leu Phe Phe Leu 
                565                 570                 575     


Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val Val 
            580                 585                 590         


Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr 
        595                 600                 605             


Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu 
    610                 615                 620                 


Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His 
625                 630                 635                 640 


Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln 
                645                 650                 655     


Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala 
            660                 665                 670         


Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe 
        675                 680                 685             


Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn 
    690                 695                 700                 


Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro 
705                 710                 715                 720 


Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu 
                725                 730                 735     


Pro Pro Cys Val Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln 
            740                 745                 750         


Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val 
        755                 760                 765             


Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His 
    770                 775                 780                 


Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg 
785                 790                 795                 800 


Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg 
                805                 810                 815     


Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu 
            820                 825                 830         


Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His 
        835                 840                 845             


Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr Leu Ala 
    850                 855                 860                 


Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His Leu Gln 
865                 870                 875                 880 


Arg Ala Leu Val Leu Arg Arg Lys Arg 
                885                 


<210>  117
<211>  479
<212>  PRT
<213>  artificial sequence

<220>
<223>  C10.BBZ (EGFR CAR)

<400>  117

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Glu Val Gln Leu Val 
            20                  25                  30          


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        35                  40                  45              


Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val 
    50                  55                  60                  


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro 
65                  70                  75                  80  


Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
                85                  90                  95      


Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            100                 105                 110         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Glu Gly 
        115                 120                 125             


Pro Tyr Cys Ser Ser Thr Ser Cys Tyr Gly Ala Phe Asp Ile Trp Gly 
    130                 135                 140                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Asp Pro 
                165                 170                 175     


Ala Val Ser Val Ala Leu Gly Gln Thr Val Lys Ile Thr Cys Gln Gly 
            180                 185                 190         


Asp Ser Leu Arg Ser Tyr Phe Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
        195                 200                 205             


Gln Ala Pro Thr Leu Val Met Tyr Ala Arg Asn Asp Arg Pro Ala Gly 
    210                 215                 220                 


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
225                 230                 235                 240 


Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
                245                 250                 255     


Ala Trp Asp Asp Ser Leu Asn Gly Tyr Leu Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Thr Val Leu Gly Arg Val Thr Val Ser Ser Ala Glu Pro Lys Ser 
        275                 280                 285             


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Gly Ser Ile Tyr Ile 
    290                 295                 300                 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
305                 310                 315                 320 


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
                325                 330                 335     


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            340                 345                 350         


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
        355                 360                 365             


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
    370                 375                 380                 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
385                 390                 395                 400 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
                405                 410                 415     


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
            420                 425                 430         


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
        435                 440                 445             


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
    450                 455                 460                 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475                 


<210>  118
<211>  333
<212>  PRT
<213>  artificial sequence

<220>
<223>  7G3L.BBZ (CD123 CAR)

<400>  118

Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
1               5                   10                  15      


Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln 
            20                  25                  30          


Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser 
                85                  90                  95      


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        115                 120                 125             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    130                 135                 140                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
145                 150                 155                 160 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                165                 170                 175     


Thr Leu Tyr Cys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            180                 185                 190         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        195                 200                 205             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    210                 215                 220                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
225                 230                 235                 240 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                245                 250                 255     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            260                 265                 270         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        275                 280                 285             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    290                 295                 300                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
305                 310                 315                 320 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330             


<210>  119
<211>  508
<212>  PRT
<213>  artificial sequence

<220>
<223>  3A1e.BBZ (CD7 CAR)

<400>  119

Met Leu Glu Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala 
            20                  25                  30          


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val 
        35                  40                  45              


Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
    50                  55                  60                  


Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
65                  70                  75                  80  


Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr 
                85                  90                  95      


Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
            100                 105                 110         


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
        115                 120                 125             


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
    130                 135                 140                 


Gln Asp Gly Tyr Tyr Pro Gly Trp Phe Ala Asn Trp Gly Gln Gly Thr 
145                 150                 155                 160 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met 
            180                 185                 190         


Ser Ala Ser Leu Gly Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Ser 
        195                 200                 205             


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro 
    210                 215                 220                 


Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser 
225                 230                 235                 240 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser 
                245                 250                 255     


Ser Val Glu Ala Glu Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser 
            260                 265                 270         


Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        355                 360                 365             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    370                 375                 380                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  120
<211>  507
<212>  PRT
<213>  artificial sequence

<220>
<223>  14.g2a.BBZ (GD2 CAR)

<400>  120

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Asp Ile Leu Leu Thr Gln Thr Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
    130                 135                 140                 


Phe Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Lys Leu Gln 
145                 150                 155                 160 


Gln Ser Gly Pro Ser Leu Val Glu Pro Gly Ala Ser Val Met Ile Ser 
                165                 170                 175     


Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val 
            180                 185                 190         


Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro 
        195                 200                 205             


Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser 
225                 230                 235                 240 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
            260                 265                 270         


Pro Pro Ser Val Tyr Gly Arg Val Thr Val Ser Ser Thr Thr Thr Pro 
        275                 280                 285             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    290                 295                 300                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
305                 310                 315                 320 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            340                 345                 350         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        355                 360                 365             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    370                 375                 380                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
385                 390                 395                 400 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                405                 410                 415     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            420                 425                 430         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        435                 440                 445             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    450                 455                 460                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
465                 470                 475                 480 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                485                 490                 495     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505         


<210>  121
<211>  483
<212>  PRT
<213>  artificial sequence

<220>
<223>  2B3.BBZ (PSCA CAR)

<400>  121

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Val Arg Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
                165                 170                 175     


Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Val Ala Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys 
        195                 200                 205             


Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Lys Thr Gly Gly Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Ala Ala Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  122
<211>  270
<212>  PRT
<213>  artificial sequence

<220>
<223>  NY-ESO-1 TCR alpha chain

<400>  122

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Ala Gly Lys Ser Thr Phe Gly Asp Gly Thr Thr Leu Thr Val Lys 
        115                 120                 125             


Pro Asn Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Ala Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  123
<211>  308
<212>  PRT
<213>  artificial sequence

<220>
<223>  NY-ESO-1 TCR beta chain

<400>  123

Met Asp Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Thr Ile Gly Ala Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
        115                 120                 125             


Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Phe 
305             


<210>  124
<211>  603
<212>  PRT
<213>  artificial sequence

<220>
<223>  EBV16-E7 TCR

<400>  124

Met Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Ser Val Asp Gly Asn Asn 
            100                 105                 110         


Arg Leu Ala Phe Gly Lys Gly Asn Gln Val Val Val Ile Pro Asn Ile 
        115                 120                 125             


Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser 
    130                 135                 140                 


Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val 
145                 150                 155                 160 


Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu 
                165                 170                 175     


Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser 
            180                 185                 190         


Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile 
        195                 200                 205             


Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys 
    210                 215                 220                 


Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Glu 
            260                 265                 270         


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
        275                 280                 285             


Pro Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly 
    290                 295                 300                 


Ala Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile 
305                 310                 315                 320 


Lys Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly 
                325                 330                 335     


His Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln 
            340                 345                 350         


Phe Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe 
        355                 360                 365             


Pro Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu 
    370                 375                 380                 


Asn Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala 
385                 390                 395                 400 


Ser Ser Leu Gly Trp Arg Gly Gly Arg Tyr Asn Glu Gln Phe Phe Gly 
                405                 410                 415     


Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro 
            420                 425                 430         


Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr 
        435                 440                 445             


Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His 
    450                 455                 460                 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
465                 470                 475                 480 


Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser 
                485                 490                 495     


Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln 
            500                 505                 510         


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser 
        515                 520                 525             


Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile 
    530                 535                 540                 


Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu 
545                 550                 555                 560 


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
                565                 570                 575     


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu 
            580                 585                 590         


Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
        595                 600             


<210>  125
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  EBV16-E7 TCR alpha chain

<400>  125

Met Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Ser Val Asp Gly Asn Asn 
            100                 105                 110         


Arg Leu Ala Phe Gly Lys Gly Asn Gln Val Val Val Ile Pro Asn Ile 
        115                 120                 125             


Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser 
    130                 135                 140                 


Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val 
145                 150                 155                 160 


Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu 
                165                 170                 175     


Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser 
            180                 185                 190         


Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile 
        195                 200                 205             


Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys 
    210                 215                 220                 


Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  126
<211>  314
<212>  PRT
<213>  artificial sequence

<220>
<223>  EBV16-E7 TCR beta

<400>  126

Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Trp Arg Gly Gly Arg Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  127
<211>  606
<212>  PRT
<213>  artificial sequence

<220>
<223>  H3.3K27M TCR

<400>  127

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Glu Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp 
        275                 280                 285             


Val Glu Ser Asn Pro Gly Pro Met Gly Pro Gln Leu Leu Gly Tyr Val 
    290                 295                 300                 


Val Leu Cys Leu Leu Gly Ala Gly Pro Leu Glu Ala Gln Val Thr Gln 
305                 310                 315                 320 


Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys Leu Thr Val Thr 
                325                 330                 335     


Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp Tyr Arg Gln Asp 
            340                 345                 350         


Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met Asn Val Glu Val 
        355                 360                 365             


Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val Ser Arg Lys Glu 
    370                 375                 380                 


Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Asn Pro Asn Gln Thr 
385                 390                 395                 400 


Ser Leu Tyr Phe Cys Ala Ser Gly Trp Gly Gly Pro Phe Tyr Glu Gln 
                405                 410                 415     


Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn 
            420                 425                 430         


Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile 
        435                 440                 445             


Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr 
    450                 455                 460                 


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
465                 470                 475                 480 


Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu 
                485                 490                 495     


Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
            500                 505                 510         


Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr 
        515                 520                 525             


Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val 
    530                 535                 540                 


Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe 
545                 550                 555                 560 


Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
                565                 570                 575     


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala 
            580                 585                 590         


Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
        595                 600                 605     


<210>  128
<211>  273
<212>  PRT
<213>  artificial sequence

<220>
<223>  H3.3K27M TCR alpha chain

<400>  128

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Glu Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  129
<211>  311
<212>  PRT
<213>  artificial sequence

<220>
<223>  H3.3K27M TCR beta chain

<400>  129

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Asn Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Gly Trp Gly Gly Pro Phe Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  130
<211>  533
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD19-CD3 BiTE

<400>  130

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln Leu Thr 
            20                  25                  30          


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        35                  40                  45              


Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Lys Val 
            100                 105                 110         


Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr Glu Asp Pro Trp Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val Lys Ile Ser Cys Lys 
                165                 170                 175     


Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln Ile Trp Pro Gly Asp 
        195                 200                 205             


Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr 
    210                 215                 220                 


Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Ala 
225                 230                 235                 240 


Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Glu Thr Thr Thr 
                245                 250                 255     


Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln 
        275                 280                 285             


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    290                 295                 300                 


Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
305                 310                 315                 320 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                325                 330                 335     


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
            340                 345                 350         


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        355                 360                 365             


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp 
    370                 375                 380                 


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
385                 390                 395                 400 


Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                405                 410                 415     


Gly Val Asp Asp Ala Ala Ile Gln Leu Thr Gln Ser Pro Ala Ile Met 
            420                 425                 430         


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
        435                 440                 445             


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro 
    450                 455                 460                 


Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr 
465                 470                 475                 480 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                485                 490                 495     


Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            500                 505                 510         


Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys His 
        515                 520                 525             


His His His His His 
    530             


<210>  131
<211>  521
<212>  PRT
<213>  artificial sequence

<220>
<223>  139-CD3 (EGFRvIII BiTE)

<400>  131

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln Met Thr 
            20                  25                  30          


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        35                  40                  45              


Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asn Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Asn 
65                  70                  75                  80  


Leu Gln Ser Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Glu Phe Thr Leu Ile Val Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Leu Gln His His Ser Tyr Pro Leu Thr Ser Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Val Leu Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Asn 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Gly Ser Ser Gly Trp Ser Glu Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile 
            260                 265                 270         


Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val 
        275                 280                 285             


Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met 
    290                 295                 300                 


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
305                 310                 315                 320 


Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
                325                 330                 335     


Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
            340                 345                 350         


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
        355                 360                 365             


Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Val Asp Asp Ala Ala Ile Gln Leu Thr Gln Ser 
                405                 410                 415     


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
            420                 425                 430         


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
        435                 440                 445             


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
    450                 455                 460                 


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
465                 470                 475                 480 


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
                485                 490                 495     


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
            500                 505                 510         


Glu Leu Lys His His His His His His 
        515                 520     


<210>  132
<211>  909
<212>  DNA
<213>  artificial sequence

<220>
<223>  40L.28.40L.40L

<400>  132
atgatcgaaa catacaacca aacttctccc cgatctgcgg ccactggact gcccatcagc       60

atgaaaagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc      120

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc      180

tatcgctcca tttttatgta tttacttact gtttttctta tcacccagat gattgggtca      240

gcactttttg ctgtgtatct tcatagaagg ttggacaaga tagaagatga aaggaatctt      300

catgaagatt ttgtattcat gaaaacgata cagagatgca acacaggaga aagatcctta      360

tccttactga actgtgagga gattaaaagc cagtttgaag gctttgtgaa ggatataatg      420

ttaaacaaag aggagacgaa gaaagaaaac agctttgaaa tgcaaaaagg tgatcagaat      480

cctcaaattg cggcacatgt cataagtgag gccagcagta aaacaacatc tgtgttacag      540

tgggctgaaa aaggatacta caccatgagc aacaacttgg taaccctgga aaatgggaaa      600

cagctgaccg ttaaaagaca aggactctat tatatctatg cccaagtcac cttctgttcc      660

aatcgggaag cttcgagtca agctccattt atagccagcc tctgcctaaa gtcccccggt      720

agattcgaga gaatcttact cagagctgca aatacccaca gttccgccaa accttgcggg      780

caacaatcca ttcacttggg aggagtattt gaattgcaac caggtgcttc ggtgtttgtc      840

aatgtgactg atccaagcca agtgagccat ggcactggct tcacgtcctt tggcttactc      900

aaactctga                                                              909


<210>  133
<211>  1328
<212>  DNA
<213>  artificial sequence

<220>
<223>  1412-T4-CD40L

<400>  133
atggccctcc ccgtgacggc actgctgcta cctctggcac tgctgctgca cgccgcgcgt       60

ccccaggtgc agctggtgca gtccggagcc gaggtaaaga agccaggcgc ttccgtcaag      120

gtgtcatgca aggcctcagg ctacaccttc acaagctatt acatccactg ggtgcgccaa      180

gctcccggtc agggcttgga gtggatcggg tgcatttacc cagggaacgt caacacaaac      240

tacaacgaga agttcaagga tcgggcaacc ctgaccgtgg acacatccat ctctaccgcc      300

tacatggagc tgtcacgcct gcgctctgat gacaccgcag tgtacttctg taccaggagt      360

cactacggcc tggactggaa ctttgatgtc tggggccagg gaaccaccgt gacggtgtcc      420

agtgtggagg gcggtagtgg cggctctggt gggtccggag gctcaggcgg cgtgatggat      480

gacattcaga tgacccagag tccctcctcc ctctccgctt ccgtcggaga ccgcgtgacc      540

atcacttgtc acgcctcaca gaatatctac gtgtggctga actggtacca acagaagccc      600

ggcaaggccc ccaagctgct tatctataaa gcgtccaacc tccacacggg agtcccttcc      660

cgcttctccg gatccggcag tgggacggac ttcacactca caatctcgtc gctgcagcca      720

gaggactttg cgacgtacta ctgccagcag ggccagacct acccatatac tttcggcggc      780

gggaccaagg tggagattaa gggatacatc cccgaggccc cgcgcgacgg gcaggcatac      840

gtgaggaaag acggtgagtg ggtcctgctg agcacctttc tcggtgatca gaatcctcaa      900

attgcggcac atgtcataag tgaggccagc agtaaaacaa catctgtgtt acagtgggct      960

gaaaaaggat actacaccat gagcaacaac ttggtaaccc tggaaaatgg gaaacagctg     1020

accgttaaaa gacaaggact ctattatatc tatgcccaag tcaccttctg ttccaatcgg     1080

gaagcttcga gtcaagctcc atttatagcc agcctctgcc taaagtcccc cggtagattc     1140

gagagaatct tactcagagc tgcaaatacc cacagttccg ccaaaccttg cgggcaacaa     1200

tccattcact tgggaggagt atttgaattg caaccaggtg cttcggtgtt tgtcaatgtg     1260

actgatccaa gccaagtgag ccatggcact ggcttcacgt cctttggctt actcaaactc     1320

tgagtcga                                                              1328


<210>  134
<211>  1566
<212>  DNA
<213>  artificial sequence

<220>
<223>  1412-F2.103

<400>  134
atggccctcc ccgtgacggc actgctgcta cctctggcac tgctgctgca cgccgcgcgt       60

ccccaggtgc agctggtgca gtccggagcc gaggtaaaga agccaggcgc ttccgtcaag      120

gtgtcatgca aggcctcagg ctacaccttc acaagctatt acatccactg ggtgcgccaa      180

gctcccggtc agggcttgga gtggatcggg tgcatttacc cagggaacgt caacacaaac      240

tacaacgaga agttcaagga tcgggcaacc ctgaccgtgg acacatccat ctctaccgcc      300

tacatggagc tgtcacgcct gcgctctgat gacaccgcag tgtacttctg taccaggagt      360

cactacggcc tggactggaa ctttgatgtc tggggccagg gaaccaccgt gacggtgtcc      420

agtgtggagg gcggtagtgg cggctctggt gggtccggag gctcaggcgg cgtgatggat      480

gacattcaga tgacccagag tccctcctcc ctctccgctt ccgtcggaga ccgcgtgacc      540

atcacttgtc acgcctcaca gaatatctac gtgtggctga actggtacca acagaagccc      600

ggcaaggccc ccaagctgct tatctataaa gcgtccaacc tccacacggg agtcccttcc      660

cgcttctccg gatccggcag tgggacggac ttcacactca caatctcgtc gctgcagcca      720

gaggactttg cgacgtacta ctgccagcag ggccagacct acccatatac tttcggcggc      780

gggaccaagg tggagattaa gggaggtggt ggatccgagg tgcagctggt ggagtccggg      840

ggaggcttag ttcagcctgg ggggtccctg agactctcct gtgcagtctc tggattcacc      900

ttcagtacct actggatgca ctgggtccgc caagctccag ggaaggggct ggtgtgggtc      960

tcacgtatta atagtgatgg gagtagcaca acctacgcgg actccgtgaa gggccgattc     1020

accatctcca gagacaacgc caagaacacg ctgtatctgc aaatgaacag tctgagagcc     1080

gaggacacgg ctgtgtatta ctgtgcaaga gatagagtac tatggatcgg ggagttatcc     1140

tactacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc aggtggcggt     1200

ggctcgggcg gtggtgggtc gggtggcggc ggatctgaca tccagatgac ccagtctcct     1260

tccaccctgt ctgcatctgt aggagacaga gtcaccatca cttgccgggc cagtcagagt     1320

attagtaact ggttggcctg gtatcagcag aaaccaggga aagcccctaa actcctgctc     1380

tataaggcat ctggtttaga aagtggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagaattca ctctcaccat caacagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtcta atagttattc gtggacgttc ggccacggga ccaaggtgga aatcaaacgt     1560

acgtaa                                                                1566


<210>  135
<211>  1599
<212>  DNA
<213>  artificial sequence

<220>
<223>  1412-F5.157

<400>  135
atggccctcc ccgtgacggc actgctgcta cctctggcac tgctgctgca cgccgcgcgt       60

ccccaggtgc agctggtgca gtccggagcc gaggtaaaga agccaggcgc ttccgtcaag      120

gtgtcatgca aggcctcagg ctacaccttc acaagctatt acatccactg ggtgcgccaa      180

gctcccggtc agggcttgga gtggatcggg tgcatttacc cagggaacgt caacacaaac      240

tacaacgaga agttcaagga tcgggcaacc ctgaccgtgg acacatccat ctctaccgcc      300

tacatggagc tgtcacgcct gcgctctgat gacaccgcag tgtacttctg taccaggagt      360

cactacggcc tggactggaa ctttgatgtc tggggccagg gaaccaccgt gacggtgtcc      420

agtgtggagg gcggtagtgg cggctctggt gggtccggag gctcaggcgg cgtgatggat      480

gacattcaga tgacccagag tccctcctcc ctctccgctt ccgtcggaga ccgcgtgacc      540

atcacttgtc acgcctcaca gaatatctac gtgtggctga actggtacca acagaagccc      600

ggcaaggccc ccaagctgct tatctataaa gcgtccaacc tccacacggg agtcccttcc      660

cgcttctccg gatccggcag tgggacggac ttcacactca caatctcgtc gctgcagcca      720

gaggactttg cgacgtacta ctgccagcag ggccagacct acccatatac tttcggcggc      780

gggaccaagg tggagattaa gggaggtggt ggatccgagg tgcagctgtt ggagtctggg      840

ggaggcttgg tacagcctgg ggggtccctg agactctcct gtgcagcctc tggattcgcc      900

tttagcagct atgccatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtc      960

tcagctatta gtggtagtgg tggtagcaca tactacgcag actccgtgaa gggccggttc     1020

accatctcca gagacaattc caagaacacg ctgtatctgc aaatgaacag cctgagaccg     1080

aggacacggc cgtatattac tgtgcgaaag atggggggta ctatggttcg gggagttatg     1140

ggtactttga ctactggggc cagggaaccc tggtcaccgt ctcctcaggg tggcggtggc     1200

tcgggcggtg gtgggtcggg tggcggcgga tctatccaga tgacccagtc tccatcttcc     1260

gtgtctgcat ctgcaggaga cagagtcacc atcacttgtc gggcgagtca gggtattagc     1320

agctggttag cctggtatca acagaaacca gggaaagccc ctaagctcct gatctatgct     1380

ggatccagtt tgcaaagtgg ggtcccatca aggttcagcg gcagtggatt tgggacagat     1440

ttcactctca ccatcggcag cctgcagcct gaagattttg caacttacta ttgtcaacag     1500

gctagcagtt tccctcggac gttcggccaa gggaccaagg tggagatcaa acgtacggtg     1560

ctgcaccatc tgtcttcatc ttcccgccat ctgatgagc                            1599


<210>  136
<211>  1560
<212>  DNA
<213>  artificial sequence

<220>
<223>  1412-F5.77

<400>  136
atggccctcc ccgtgacggc actgctgcta cctctggcac tgctgctgca cgccgcgcgt       60

ccccaggtgc agctggtgca gtccggagcc gaggtaaaga agccaggcgc ttccgtcaag      120

gtgtcatgca aggcctcagg ctacaccttc acaagctatt acatccactg ggtgcgccaa      180

gctcccggtc agggcttgga gtggatcggg tgcatttacc cagggaacgt caacacaaac      240

tacaacgaga agttcaagga tcgggcaacc ctgaccgtgg acacatccat ctctaccgcc      300

tacatggagc tgtcacgcct gcgctctgat gacaccgcag tgtacttctg taccaggagt      360

cactacggcc tggactggaa ctttgatgtc tggggccagg gaaccaccgt gacggtgtcc      420

agtgtggagg gcggtagtgg cggctctggt gggtccggag gctcaggcgg cgtgatggat      480

gacattcaga tgacccagag tccctcctcc ctctccgctt ccgtcggaga ccgcgtgacc      540

atcacttgtc acgcctcaca gaatatctac gtgtggctga actggtacca acagaagccc      600

ggcaaggccc ccaagctgct tatctataaa gcgtccaacc tccacacggg agtcccttcc      660

cgcttctccg gatccggcag tgggacggac ttcacactca caatctcgtc gctgcagcca      720

gaggactttg cgacgtacta ctgccagcag ggccagacct acccatatac tttcggcggc      780

gggaccaagg tggagattaa gggaggtggt ggatccgagg tgcagctgtt ggagtctggg      840

ggaggcttgg tacagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc      900

tttagcagct atgccatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtc      960

tcagctatta gtggtagtgg tggtagcaca tactacgcag actccgtgaa gggccggttc     1020

accatctcca gagacaattc caagaacacg ctgtatctgc aaatgaacag cctgagagcc     1080

gaggacacgg ccgtatatta ctgtgcgaaa gatggggggt actatggttc ggggagttat     1140

gggtactttg actactgggg ccagggaacc ctggtcaccg tctcctcagg tggcggtggc     1200

tcgggcggtg gtgggtcggg tggcggcgga tctgacatcc agatgaccca gtctccatct     1260

tccgtgtctg gatctgtagg agacagagtc accatcactt gtcgggcgag tcagggtatt     1320

agcagctggt tagcctggta tcagcagaaa ccagggaaag cccctaagct cctgatctat     1380

gctggatcca gtttgcaaag tggggtccca tcaaggttca gcggcagtgg atttgggaca     1440

gatttcactc tcaccatcag cagcctgcag cctgaagatt ttgcaactta ctattgtcaa     1500

caggctagca gtttccctcg gacattcggc caagggacca aggtggagat caaacgtacg     1560


<210>  137
<211>  1158
<212>  DNA
<213>  artificial sequence

<220>
<223>  F2.103.CD28

<400>  137
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtccggggga ggcttagttc agcctggggg gtccctgaga      120

ctctcctgtg cagtctctgg attcaccttc agtacctact ggatgcactg ggtccgccaa      180

gctccaggga aggggctggt gtgggtctca cgtattaata gtgatgggag tagcacaacc      240

tacgcggact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacgctg      300

tatctgcaaa tgaacagtct gagagccgag gacacggctg tgtattactg tgcaagagat      360

agagtactat ggatcgggga gttatcctac tacggtatgg acgtctgggg ccaagggacc      420

acggtcaccg tctcctcagg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga      480

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc      540

accatcactt gccgggccag tcagagtatt agtaactggt tggcctggta tcagcagaaa      600

ccagggaaag cccctaaact cctgctctat aaggcatctg gtttagaaag tggggtccca      660

tcaaggttca gcggcagtgg atctgggaca gaattcactc tcaccatcaa cagcctgcag      720

cctgatgatt ttgcaactta ttactgccaa cagtctaata gttattcgtg gacgttcggc      780

cacgggacca aggtggaaat caaacgtacg gctagcacca cgacgccagc gccgcgacca      840

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg      900

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tttttgggtg      960

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt     1020

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact     1080

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc     1140

gcagcctatc gctcctaa                                                   1158


<210>  138
<211>  1194
<212>  DNA
<213>  artificial sequence

<220>
<223>  F5.157.CD28

<400>  138
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcgccttt agcagctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gctattagtg gtagtggtgg tagcacatac      240

tacgcagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg      300

tatctgcaaa tgaacagcct gagaccgagg acacggccgt atattactgt gcgaaagatg      360

gggggtacta tggttcgggg agttatgggt actttgacta ctggggccag ggaaccctgg      420

tcaccgtctc ctcagggtgg cggtggctcg ggcggtggtg ggtcgggtgg cggcggatct      480

atccagatga cccagtctcc atcttccgtg tctgcatctg caggagacag agtcaccatc      540

acttgtcggg cgagtcaggg tattagcagc tggttagcct ggtatcaaca gaaaccaggg      600

aaagccccta agctcctgat ctatgctgga tccagtttgc aaagtggggt cccatcaagg      660

ttcagcggca gtggatttgg gacagatttc actctcacca tcggcagcct gcagcctgaa      720

gattttgcaa cttactattg tcaacaggct agcagtttcc ctcggacgtt cggccaaggg      780

accaaggtgg agatcaaacg tacggtgctg caccatctgt cttcatcttc ccgccatctg      840

atgagcgcta gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      900

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      960

acgagggggc tggacttcgc ctgtgatttt tgggtgctgg tggtggttgg tggagtcctg     1020

gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgag gagtaagagg     1080

agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc     1140

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc ctaa           1194


<210>  139
<211>  1155
<212>  DNA
<213>  artificial sequence

<220>
<223>  F5.77.CD28

<400>  139
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttt agcagctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gctattagtg gtagtggtgg tagcacatac      240

tacgcagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tatattactg tgcgaaagat      360

ggggggtact atggttcggg gagttatggg tactttgact actggggcca gggaaccctg      420

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgggtgg cggcggatct      480

gacatccaga tgacccagtc tccatcttcc gtgtctggat ctgtaggaga cagagtcacc      540

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      600

gggaaagccc ctaagctcct gatctatgct ggatccagtt tgcaaagtgg ggtcccatca      660

aggttcagcg gcagtggatt tgggacagat ttcactctca ccatcagcag cctgcagcct      720

gaagattttg caacttacta ttgtcaacag gctagcagtt tccctcggac attcggccaa      780

gggaccaagg tggagatcaa acgtacggct agcaccacga cgccagcgcc gcgaccacca      840

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      900

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgattt ttgggtgctg      960

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1020

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1080

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1140

gcctatcgct cctaa                                                      1155


<210>  140
<211>  1140
<212>  DNA
<213>  artificial sequence

<220>
<223>  F2.103.BB

<400>  140
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtccggggga ggcttagttc agcctggggg gtccctgaga      120

ctctcctgtg cagtctctgg attcaccttc agtacctact ggatgcactg ggtccgccaa      180

gctccaggga aggggctggt gtgggtctca cgtattaata gtgatgggag tagcacaacc      240

tacgcggact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacgctg      300

tatctgcaaa tgaacagtct gagagccgag gacacggctg tgtattactg tgcaagagat      360

agagtactat ggatcgggga gttatcctac tacggtatgg acgtctgggg ccaagggacc      420

acggtcaccg tctcctcagg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga      480

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc      540

accatcactt gccgggccag tcagagtatt agtaactggt tggcctggta tcagcagaaa      600

ccagggaaag cccctaaact cctgctctat aaggcatctg gtttagaaag tggggtccca      660

tcaaggttca gcggcagtgg atctgggaca gaattcactc tcaccatcaa cagcctgcag      720

cctgatgatt ttgcaactta ttactgccaa cagtctaata gttattcgtg gacgttcggc      780

cacgggacca aggtggaaat caaacgtacg accacgacgc cagcgccgcg accaccaaca      840

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      900

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgccgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaataa     1140


<210>  141
<211>  1176
<212>  DNA
<213>  artificial sequence

<220>
<223>  F5.157.BB

<400>  141
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcgccttt agcagctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gctattagtg gtagtggtgg tagcacatac      240

tacgcagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg      300

tatctgcaaa tgaacagcct gagaccgagg acacggccgt atattactgt gcgaaagatg      360

gggggtacta tggttcgggg agttatgggt actttgacta ctggggccag ggaaccctgg      420

tcaccgtctc ctcagggtgg cggtggctcg ggcggtggtg ggtcgggtgg cggcggatct      480

atccagatga cccagtctcc atcttccgtg tctgcatctg caggagacag agtcaccatc      540

acttgtcggg cgagtcaggg tattagcagc tggttagcct ggtatcaaca gaaaccaggg      600

aaagccccta agctcctgat ctatgctgga tccagtttgc aaagtggggt cccatcaagg      660

ttcagcggca gtggatttgg gacagatttc actctcacca tcggcagcct gcagcctgaa      720

gattttgcaa cttactattg tcaacaggct agcagtttcc ctcggacgtt cggccaaggg      780

accaaggtgg agatcaaacg tacggtgctg caccatctgt cttcatcttc ccgccatctg      840

atgagcacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      900

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      960

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc     1020

cttctcctgt cactggttat caccctttac tgccggggca gaaagaaact cctgtatata     1080

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1140

cgatttccag aagaagaaga aggaggatgt gaataa                               1176


<210>  142
<211>  1137
<212>  DNA
<213>  artificial sequence

<220>
<223>  F5.77.BB

<400>  142
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttt agcagctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gctattagtg gtagtggtgg tagcacatac      240

tacgcagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tatattactg tgcgaaagat      360

ggggggtact atggttcggg gagttatggg tactttgact actggggcca gggaaccctg      420

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgggtgg cggcggatct      480

gacatccaga tgacccagtc tccatcttcc gtgtctggat ctgtaggaga cagagtcacc      540

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      600

gggaaagccc ctaagctcct gatctatgct ggatccagtt tgcaaagtgg ggtcccatca      660

aggttcagcg gcagtggatt tgggacagat ttcactctca ccatcagcag cctgcagcct      720

gaagattttg caacttacta ttgtcaacag gctagcagtt tccctcggac attcggccaa      780

gggaccaagg tggagatcaa acgtacgacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgccggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaataa        1137


<210>  143
<211>  1149
<212>  DNA
<213>  artificial sequence

<220>
<223>  4D11.CD28

<400>  143
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcagctgc agctgcagga gtcgggccca ggactactga agccttcgga gaccctgtcc      120

ctcacctgca ctgtctctgg cggctccatc agcagtcctg gttactacgg gggctggatc      180

cgccagcccc cagggaaggg gctggagtgg attgggagta tctataaaag tgggagcacc      240

taccacaacc cgtccctcaa gagtcgagtc accatatccg tagacacgtc caagaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcagacacgg ctgtgtatta ctgtacgaga      360

cctgtagtac gatattttgg gtggttcgac ccctggggcc agggaaccct ggtcaccgtc      420

tcctcagcta gcggtggcgg tggctcgggc ggtggtgggt cgggtggcgg cggatctgcc      480

atccagttga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      540

acttgccggg caagtcaggg cattagcagt gctttagcct ggtatcagca gaaaccaggg      600

aaagctccta agctcctgat ctatgatgcc tccaatttgg aaagtggggt cccatcaagg      660

ttcagcggca gtggatctgg gacagatttc actctcacca tcagcagcct gcagcctgaa      720

gattttgcaa cttattactg tcaacagttt aatagttacc cgacgttcgg ccaagggacc      780

aaggtggaaa tcaaacgtac ggctagcacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atttttgggt gctggtggtg      960

gttggtggag tcctggcttg ctatagcttg ctagtaacag tggcctttat tattttctgg     1020

gtgaggagta agaggagcag gctcctgcac agtgactaca tgaacatgac tccccgccgc     1080

cccgggccca cccgcaagca ttaccagccc tatgccccac cacgcgactt cgcagcctat     1140

cgctcctaa                                                             1149


<210>  144
<211>  1134
<212>  DNA
<213>  artificial sequence

<220>
<223>  A40C.CD28

<400>  144
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtcc agctggtaca atctggtgct gaagtgaaga aaccaggagc gtcggtgaag      120

gtctcatgca cagcctcagg cttcaacatc aaggactact acgtgcactg ggtcaagcaa      180

gctcccggac aggggctgga gtggatgggg agaattgacc cggaagacgg cgactcgaaa      240

tacgcgccga agttccaggg caaggccacc atgacagccg ataccagtac atcgaccgtt      300

tacatggagc tgtccagcct ccgctcagag gataccgcgg tatactactg tacgacctcc      360

tactacgtcg gaacgtacgg ttactggggc cagggtaccc tggtgacagt gtcctcgggg      420

ggcggcgggt ctggcggggg aggcagcggg ggcggcgggt cggacatcca gatgactcaa      480

tccccctctt ccctgagtgc gtccgtgggt gacagggtga cgatcacttg tagcgcttcg      540

tcctcggtgt cgtatatgct gtggttccag cagaagcccg gtaaggcccc caaactgctc      600

atttattcca ccagcaacct cgccagtggc gtacccagtc gcttctccgg tagtggctcc      660

ggtaccgatt tcacactgac catctccagt ctgcaacctg aagacttcgc aacgtactat      720

tgtcagcagc gcacattcta tccctatacg tttgggggcg ggaccaaggt cgagatcaag      780

cgcacagcta gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatttt tgggtgctgg tggtggttgg tggagtcctg      960

gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc ctaa           1134


<210>  145
<211>  1158
<212>  DNA
<213>  artificial sequence

<220>
<223>  119.CD28

<400>  145
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtcc aactgcagca gtcaggtcca ggactggtga agccctcgca gaccctctca      120

ctcacctgtg ccatctccgg ggacagtgtc tctagcaaca gtgctacttg gaactggatc      180

aggcagtccc catcgagaga ccttgagtgg ctgggaagga catactacag gtccaagtgg      240

tatcgtgatt atgtaggatc tgtgaaaagt cgaataatca tcaacccaga cacatccaac      300

aaccagttct ccctgcagct gaactctgtg actcccgagg acacggctat atattactgt      360

acaagagcac agtggctggg aggggattac ccctactact acagtatgga cgtctggggc      420

caagggacca cggtcaccgt ctcttcaggt ggcggtggct cgggcggtgg tgggtcgggt      480

ggcggcggat ctgagatcgt gctgacgcag agtcccgcca ccctgtccct gtcgcccggc      540

gagcgggcca ctctctcctg cagggccagt cagtccgtgt ccagttatct cgcatggtac      600

caacagaagc cagggcaggc ccctcggctg ctcatatacg acgcttcaaa tcgcgccacc      660

gggatccctg caaggttctc cggctccggc agtggcaccg attttaccct cacaatttcc      720

tccctggagc cggaggactt cgccgtgtat tactgccaac agaggagtaa caccttcggc      780

cccggcacaa aggtcgacat taagcgcact gctagcacca cgacgccagc gccgcgacca      840

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg      900

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tttttgggtg      960

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt     1020

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact     1080

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc     1140

gcagcctatc gctcctaa                                                   1158


<210>  146
<211>  1470
<212>  DNA
<213>  artificial sequence

<220>
<223>  4D5.BBZ (Her2 CAR)

<400>  146
atggacttcc aggttcagat cttttcgttc ctgctgatca gcgcctctgt tatcatgtcg       60

cgcggcgaca tccagatgac ccagtcccct tcctccctct ctgcctctgt gggagaccgc      120

gttaccatca catgccgagc ttcccaggac gtgaacacag ccgtggcctg gtaccagcag      180

aagcccggga aggcacccaa actcctcatc tactccgcct ccttcctata cagtggcgtg      240

ccttcccgat tctccggctc caggagtggc acggacttta cgctcaccat tagtagcctg      300

cagcccgaag acttcgcgac ctactattgt cagcaacact acacgacgcc accaactttc      360

ggccagggta ccaaggtcga gattaagcga accggcagta ccagtgggtc tggcaagccc      420

ggcagcggcg agggatccga ggtccagctg gtcgagtccg gcgggggcct ggtgcagccg      480

ggcggctcgc tgaggttatc ttgcgccgcc agtggcttca acatcaagga tacttacatc      540

cactgggtga ggcaggctcc gggcaagggc ctggaatggg tggctaggat ctaccctact      600

aacgggtaca cacgctacgc agattcggtg aaaggccgct tcactatctc cgccgacacc      660

tcgaagaaca ctgcttacct gcagatgaac tccctcaggg ccgaagatac tgcagtctac      720

tactgctccc gctggggtgg ggacggcttc tacgccatgg acgtgtgggg tcagggcact      780

ctagttacag tgtcatccac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      840

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      900

gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg      960

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag     1020

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1080

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgac gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1320

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1440

cttcacatgc aggccctgcc ccctcgctaa                                      1470


<210>  147
<211>  1461
<212>  DNA
<213>  artificial sequence

<220>
<223>  FMC63.BBZ (CD19 CAR)

<400>  147
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  148
<211>  1467
<212>  DNA
<213>  artificial sequence

<220>
<223>  ss1.BBZ (mesothelin CAR)

<400>  148
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtacaact gcagcagtct gggcctgagc tggagaagcc tggcgcttca      120

gtgaagatat cctgcaaggc ttctggttac tcattcactg gctacaccat gaactgggtg      180

aagcagagcc atggaaagag ccttgagtgg attggactta ttactcctta caatggtgct      240

tctagctaca accagaagtt caggggcaag gccacattaa ctgtagacaa gtcatccagc      300

acagcctaca tggacctcct cagtctgaca tctgaagact ctgcagtcta tttctgtgca      360

agggggggtt acgacgggag gggttttgac tactggggcc aagggaccac ggtcaccgtc      420

tcctcaggtg gaggcggttc aggcggcggt ggctctagcg gtggcggatc ggacatcgag      480

ctcactcagt ctccagcaat catgtctgca tctccagggg agaaggtcac catgacctgc      540

agtgccagct caagtgtaag ttacatgcac tggtaccagc agaagtcagg cacctccccc      600

aaaagatgga tttatgacac atccaaactg gcttctggag tcccaggtcg cttcagtggc      660

agtgggtctg gaaactctta ctctctcaca atcagcagcg tggaggctga agatgatgca      720

acttattact gccagcagtg gagtaagcac cctctcacgt acggtgctgg gacaaagttg      780

gaaatcaaag ctagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1020

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1080

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctaa                                         1467


<210>  149
<211>  1386
<212>  DNA
<213>  artificial sequence

<220>
<223>  J591.BBZ (PSMA CAR)

<400>  149
atgacccagt ctcacaaatt catgtccaca tcagtaggag acagggtcag catcatctgt       60

aaggccagtc aagatgtggg tactgctgta gactggtatc aacagaaacc aggacaatct      120

cctaaactac tgatttattg ggcatccact cggcacactg gagtccctga tcgcttcaca      180

ggcagtggat ctgggacaga cttcactctc accattacta acgttcagtc tgaagacttg      240

gcagattatt tctgtcagca atataacagc tatcctctca cgttcggtgc tgggaccatg      300

ctggacctga aaggaggcgg aggatctggc ggcggaggaa gttctggcgg aggcagcgag      360

gtgcagctgc agcagagcgg acccgagctc gtgaagcctg gaacaagcgt gcggatcagc      420

tgcaagacca gcggctacac cttcaccgag tacaccatcc actgggtcaa gcagtcccac      480

ggcaagagcc tggagtggat cggcaatatc aaccccaaca acggcggcac cacctacaac      540

cagaagttcg aggacaaggc caccctgacc gtggacaaga gcagcagcac cgcctacatg      600

gaactgcgga gcctgaccag cgaggacagc gccgtgtact attgtgccgc cggttggaac      660

ttcgactact ggggccaggg cacaaccctg acagtgtcta gcgctagctc cggaaccacg      720

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      780

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      840

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      900

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa      960

ccatttatga gaccagtaca aactactcaa gaggaagacg gctgtagctg ccgatttcca     1020

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1080

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1140

tacgacgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1200

aagaaccctc aggaaggcct gtacaacgaa ctgcagaaag ataagatggc ggaggcctac     1260

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgacgg cctttaccag     1320

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1380

cgctaa                                                                1386


<210>  150
<211>  1599
<212>  DNA
<213>  artificial sequence

<220>
<223>  c-Met CAR

<400>  150
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg acatccagat gacccagagc cccagcagcg tgagcgccag cgtgggcgac      120

cgggtgacca tcacctgccg ggccagccag ggcatcaaca cctggctggc ctggtatcag      180

cagaagcccg gcaaggcccc caagctgctg atctacgccg ccagcagcct gaagagcggc      240

gtgcccagcc ggtttagcgg ctctggctct ggcgccgact tcaccctgac catcagcagc      300

ctgcagcccg aggacttcgc cacctactac tgccagcagg ccaacagctt ccccctgacc      360

tttggcggcg gaacaaaggt ggagatcaag ggcagcacct ccggcagcgg caagcctggc      420

agcggcgagg gcagcaccaa gggccaggtg cagctggtgc agagcggagc cgaggtgaag      480

aagcctggcg cctccgtcaa ggtgtcctgc gaggccagcg gctacacctt caccagctac      540

ggcttcagct gggtgcggca ggcaccaggc cagggcctcg agtggatggg ctggatcagc      600

gccagcaacg gcaacaccta ctacgcccag aagctgcagg gcagggtcac catgaccacc      660

gacaccagca ccagcagcgc ctacatggaa ctgcggagcc tgagaagcga cgacaccgcc      720

gtgtactact gcgccagggt gtacgccgac tacgccgatt actggggcca gggcaccctg      780

gtgaccgtgg ctagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat ttttgggtgc tggtggtggt tggtggagtc      960

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag     1020

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc     1080

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccaaacgg     1140

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1200

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1260

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1320

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1380

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1440

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1500

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1560

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                            1599


<210>  151
<211>  1452
<212>  DNA
<213>  artificial sequence

<220>
<223>  BCMA CAR

<400>  151
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtgc aattggtgga atcaggggga ggacttgtgc agcctggagg atcgctgaga      120

ctgtcatgtg ccgtgtccgg ctttgccctg tccaaccacg ggatgtcctg ggtccgccgc      180

gcgcctggaa agggcctcga atgggtgtcg ggtattgtgt acagcggtag cacctactat      240

gccgcatccg tgaaggggag attcaccatc agccgggaca actccaggaa cactctgtac      300

ctccaaatga attcgctgag gccagaggac actgccatct actactgctc cgcgcatggc      360

ggagagtccg acgtctgggg acaggggacc accgtgaccg tgtctagcgc gtccggcgga      420

ggcggcagcg ggggtcgggc atcagggggc ggcggatcgg acatccagct cacccagtcc      480

ccgagctcgc tgtccgcctc cgtgggagat cgggtcacca tcacgtgccg cgccagccag      540

tcgatttcct cctacctgaa ctggtaccaa cagaagcccg gaaaagcccc gaagcttctc      600

atctacgccg cctcgagcct gcagtcagga gtgccctcac ggttctccgg ctccggttcc      660

ggtactgatt tcaccctgac catttcctcc ctgcaaccgg aggacttcgc tacttactac      720

tgccagcagt cgtactccac cccctacact ttcggacaag gcaccaaggt cgaaatcaag      780

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      840

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      900

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      960

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc     1020

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1080

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1140

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1200

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1260

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1320

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1380

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1440

ccccctcgct aa                                                         1452


<210>  152
<211>  1095
<212>  DNA
<213>  artificial sequence

<220>
<223>  FHVH33.BBZ (BCMA CAR)

<400>  152
atggcactcc cagtaaccgc gctgttgctc cctctggccc tgctgctgca cgctgcgcgc       60

cctgaggttc agctgctgga gtccgggggc gggttagtcc agcccggcgg aagcctgcgc      120

ctgtcctgcg ccgcatccgg attcaccttc agttcgtacg ccatgagttg ggttcggcag      180

gctcccggaa agggtctgga gtgggtgtca agcatcagtg gaagtggtga ttacatctac      240

tacgccgaca gcgtcaaggg acgcttcact atcagtcggg acatctctaa gaacaccctg      300

tacctccaga tgaattccct gagggccgag gacaccgccg tctattactg cgccaaggag      360

gggaccggtg ctaactcttc cttggccgac tatcgcggtc agggcaccct agtgactgtt      420

tcgtccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      480

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      540

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc      600

cttctcctgt cactggttat caccctttac tgccggggca gaaagaaact cctgtatata      660

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc      720

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca      780

gacgcccccg cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga      840

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag      900

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg      960

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1020

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1080

ctgccccctc gctaa                                                      1095


<210>  153
<211>  1467
<212>  DNA
<213>  artificial sequence

<220>
<223>  BCMA338.BBZ (BCMA CAR)

<400>  153
atggctctgc ccgtcaccgc tctgctgctg cctctggctc tgctgctgca cgctgctcgc       60

cctcaggtca aactggaaga atctggcgga ggcctggtgc aggcaggacg gagcctgcgc      120

ctgagctgcg cagcatccga gcacaccttc agctcccacg tgatgggctg gtttcggcag      180

gccccaggca aggagagaga gagcgtggcc gtgatcggct ggagggacat ctccacatct      240

tacgccgatt ccgtgaaggg ccggttcacc atcagccggg acaacgccaa gaagacactg      300

tatctgcaga tgaacagcct gaagcccgag gacaccgccg tgtactattg cgcagcaagg      360

agaatcgacg cagcagactt tgattcctgg ggccagggca cccaggtgac agtgtctagc      420

ggaggaggag gatctgaggt gcagctggtg gagagcggag gcggcctggt gcaggccgga      480

ggctctctga ggctgagctg tgcagcatcc ggaagaacct tcacaatggg ctggtttagg      540

caggcaccag gaaaggagag ggagttcgtg gcagcaatca gcctgtcccc taccctggcc      600

tactatgccg agagcgtgaa gggcaggttt accatctccc gcgataacgc caagaataca      660

gtggtgctgc agatgaactc cctgaaacct gaggacacag ccctgtacta ttgtgccgcc      720

gatcggaaga gcgtgatgag cattagacca gactattggg ggcagggaac acaggtgacc      780

gtgagcagca ctagtaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1020

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1080

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctaa                                         1467


<210>  154
<211>  1461
<212>  DNA
<213>  artificial sequence

<220>
<223>  G33.BBZ (GPC3 CAR)

<400>  154
atggctctcc ctgtgaccgc cctcttgctg ccgctggccc tcctgctgca cgccgcacgg       60

ccgcaggtgc agctgcagca gtcgggggcc gagctggtgc ggcccggggc ctccgtcaag      120

ctgtcctgca aggccagtgg gtacaccttc actgattatg agatgcactg ggtgaagcag      180

acccctgtgc atggcctgaa atggatcggc gctctcgacc ccaagacagg tgacaccgcc      240

tacagtcaga agtttaaggg caaagcaacc ctcaccgccg acaagtcgtc ctcgaccgcc      300

tacatggagc tgaggtccct gacctccgag gattcggccg tctactactg cacccgcttc      360

tactcctaca catactgggg ccagggtacc ttagtgaccg tctcggcagg cggggggggc      420

tccgggggtg gcggcagtgg tggggggggc tccgacgtgg tgatgacaca gacccctctg      480

tccctcccag tttcgctcgg tgaccaggca tcgatctcgt gccgctcctc acagagtctg      540

gtgcactcca acggcaacac atatctgcac tggtacctcc agaagcccgg gcagtcacct      600

aagctcctca tctacaaggt gagtaatcga ttcagtggcg tgccagacag gttctccggc      660

tccgggagtg gaacggattt caccctgaag atctcccgcg tggaggcgga ggacctggga      720

gtctacttct gctcgcagaa cacccacgtc ccgcccacgt ttggcagtgg cactaagctc      780

gagatcaaaa ccacgacgcc agcgccgcga ccccccaccc cggcgccgac aatcgcatcg      840

cagcccctga gcctgaggcc cgaggcatgt aggcccgccg caggcggagc cgtccacacc      900

agggggctcg actttgcatg cgatatctac atttgggccc ctctggccgg cacctgcgga      960

gtgctcctcc tcagtctggt gatcacactc tactgtaaga ggggccgcaa gaagctgctg     1020

tacatcttca agcagccctt catgcgcccc gtccagacca cccaggaaga agatgggtgc     1080

agctgcagat tccccgagga ggaggaaggg gggtgcgaat tgcgcgttaa gttctcgcgt     1140

tccgccgacg ccccagctta caagcagggc cagaaccagc tttataacga gctcaatttg     1200

ggccggaggg aggagtacga cgtactcgac aagcgccgcg gccgcgaccc cgaaatgggt     1260

ggaaagcccc ggcgcaaaaa cccccaggag gggctgtaca acgagctgca gaaggataag     1320

atggctgagg cctactctga gatcggtatg aagggcgagc ggcgccgcgg caagggacac     1380

gatggcctgt accaggggct gtccacggcc acaaaggata cgtacgacgc tctgcacatg     1440

caggccctgc ccccccgcta a                                               1461


<210>  155
<211>  1440
<212>  DNA
<213>  artificial sequence

<220>
<223>  C10.BBZ (EGFR CAR)

<400>  155
atgggttggt cgtgcattat cctcttcctc gtcgcaaccg ctaccggcgt tcactcggat       60

tacaaggatg acgacgacaa agaggtacag ctggtgcaga gcggggccga ggttaagaag      120

cccgggtctt ccgtaaaggt gtcctgcaag gcctcggggg gcacattctc atcgtacgca      180

atatcgtggg tgcggcaggc ccccgggcag gggctggaat ggatgggcgg aattatccca      240

atcttcggga ccgccaacta tgcccagaag tttcagggtc gtgtgaccat tactgccgac      300

gagtccacca gtacggccta catggagctg agtagtctgc gtagcgagga tactgccgtt      360

tattattgcg cccgggaaga gggaccgtac tgctcgtcga cctcatgtta cggcgccttc      420

gacatctggg gccaaggcac cctggtgacg gtgtcctccg gtggtggcgg aagtggcggc      480

ggggggtccg gcgggggcgg ttcacagtcc gtcctgaccc aggatcccgc ggtgtcggtc      540

gcgctgggtc agacagtaaa gataacatgc cagggcgatt ctctgcgcag ttatttcgcc      600

tcgtggtacc agcagaaacc cggccaggct cctacccttg ttatgtacgc gcgcaatgac      660

agacccgcgg gcgtgcccga ccgcttctcc ggctcaaaga gcgggacctc cgcctccctg      720

gccatctccg ggctccagtc tgaggatgag gccgattact actgcgctgc ttgggacgac      780

tccctcaatg gctatctgtt tggcgcaggc acaaagctga ccgtgctcgg aagggtcacc      840

gtctcttcag cggagcccaa atcttgtgac aaaactcaca cctgcccacc gtgcccggga      900

tccatctaca tctgggcccc tctggccggc acctgtggcg tgctgctgct gtccctggtc      960

atcaccctgt actgcaagcg gggcagaaag aagctgctgt acatcttcaa gcagcccttc     1020

atgcggcctg tgcagaccac acaggaagag gacggctgta gctgtagatt ccccgaggaa     1080

gaggaaggcg gctgcgagct gagagtgaag ttcagcagaa gcgccgacgc ccctgcctat     1140

cagcagggcc agaaccagct gtacaacgag ctgaacctgg gcagacggga ggaatacgac     1200

gtgctggaca agagaagagg ccgggaccct gagatgggcg gcaagcccag acggaagaac     1260

ccccaggaag gcctgtataa cgaactgcag aaagacaaga tggccgaggc ctacagcgag     1320

atcggcatga agggcgagcg gagaagaggc aagggccatg acggcctgta ccagggcctg     1380

agcaccgcca ccaaggacac ctacgacgcc ctgcacatgc aggccctgcc tccaagatga     1440


<210>  156
<211>  1452
<212>  DNA
<213>  artificial sequence

<220>
<223>  2B3.BBZ (PSCA CAR)

<400>  156
atggcgctac cggtgaccgc actcctgctg ccactcgccc tcctgctcca cgccgcccgc       60

cccgatatcc agctgaccca atcaccgtcg tccctgtctg cctccgtggg cgaccgggtg      120

acgatcacct gtagtgcctc gagcagtgta cggttcatcc actggtacca acagaagccc      180

ggcaaggcac caaagcggct gatctacgac accagcaagc tggcgtctgg ggtgcccagc      240

aggttctcgg gaagtggtag tggcacagac ttcactctca ccatcagttc actccagccg      300

gaggactttg ccacctacta ttgccagcag tggtcctcgt ccccctttac cttcggccag      360

ggaacaaagg tggaaattaa gggttcgacc tccggggggg gctccggtgg gggctccggc      420

ggggggggct catcggaggt tcagctggtg gagagcggcg gcggcctggt gcagcccggc      480

gggagtctgc ggctgtcctg tgccgccagc ggcttcaaca tcaaggacta ctacattcac      540

tgggtgcggc aagccccagg caagggtctg gagtgggtgg cttggattga ccctgaaaac      600

ggcgacactg agttcgtgcc aaaattccag gggcgggcga ccatctccgc cgacacctcc      660

aagaatacgg cctacctgca gatgaactcc ctgcgcgccg aagacacagc ggtctactac      720

tgcaagacag ggggtttctg gggccagggc accctcgtga ccgtttcgag tgccgccggc      780

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      840

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      900

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      960

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc     1020

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1080

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1140

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1200

gaggagtacg acgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1260

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1320

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1380

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1440

ccccctcgct aa                                                         1452


<210>  157
<211>  1002
<212>  DNA
<213>  artificial sequence

<220>
<223>  7G3L.BBZ (CD123 CAR)

<400>  157
atgacacagt cgccagactc gctcgcggtt agcctcgggg agcgcgctac tatcaactgt       60

aagtcgtccc agtccctgct gaactcgggg aaccagaaga actacctcac ctggtacctg      120

cagaagcctg gtcagccccc aaaactgttg atctactggg ctagcacgcg ggagtcgggc      180

gtcccagacc gcttcagtgg tagcggcagt gggaccgact tcacactgac aatctcgtcg      240

cttcaggctg aggatgtggc ggtctattac tgtcagaacg actattcata cccctatacg      300

ttcggccagg gcaccaagct ggaaatcaag aggaccacga cgccagcgcc gcgaccacca      360

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      420

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg      480

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc      540

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact      600

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa      660

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag      720

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      780

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac      840

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      900

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      960

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        1002


<210>  158
<211>  1524
<212>  DNA
<213>  artificial sequence

<220>
<223>  14.g2a.BBZ (GD2 CAR)

<400>  158
atggagttcg gcctctcctg gctctttctg gtcgcgatcc tgaaaggtgt gcagtgttcc       60

agggacatcc tgctgacgca gactcccctg tctctgcccg tgtcgctggg cgaccaggcc      120

tctatctcct gcagatcatc tcagtccctg gtgcacagga atggcaatac ctacctccac      180

tggtatctgc agaagcccgg ccagtcaccc aagttgctga tccacaaggt gtccaatcgt      240

ttctcggggg tccctgaccg cttctccggg tccggcagtg gcaccgattt caccctgaag      300

atttcccgcg tggaggccga ggacctcggt gtctacttct gttcccagtc cacccacgtg      360

cccccactca cctttggcgc cggtaccaaa ctcgaactca agcgcgcgga cgcagccccc      420

acggtgtcaa tcttccccgg ttcgggcggt gggggctccg ggggagaggt gaagctgcag      480

cagagcggcc cctcgctcgt cgagccaggt gcgtccgtga tgatctcctg caaggcctcg      540

gggtcatcgt tcactggcta caacatgaac tgggtgcggc agaacattgg caagtcgctc      600

gagtggattg gggctatcga cccctattac gggggcacct cctacaacca gaagttcaaa      660

ggccgggcca ccctgactgt ggataagagc tcgtccacgg cctacatgca cctgaagtcc      720

ctgacttcag aggattcggc ggtgtactac tgcgtgagtg gcatggagta ctgggggcag      780

gggacttcgg tcaccgtctc gtccgctaag acgacccccc catccgtcta cgggcgagtt      840

acagtctcta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      900

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      960

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1020

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1080

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1140

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1200

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1260

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1320

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1380

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1440

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1500

atgcaggccc tgccccctcg ctaa                                            1524


<210>  159
<211>  1527
<212>  DNA
<213>  artificial sequence

<220>
<223>  3A1e.BBZ (CD7 CAR)

<400>  159
atgctcgagg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag       60

tccaacccag ggccgatggc cttaccagtg accgccttgc tcctgccgct ggccttgctg      120

ctccacgccg ccaggccgca ggtgaaactg caggagtccg gcggcggtct ggtcaaaccg      180

ggcggctccc tgaagttgag ctgtgcggca tccgggttca cattctcgtc atacgcaatg      240

tcctgggtcc gccagacccc cgagaagcgc ctcgaatggg tggccaccat ctcctccggt      300

ggcagttata cgtactatcc ggactcggtg aagggccggt tcaccatctc tcgcgacaac      360

gccaagaaca ctctgtacct ccagatgtcc agcctgcgct ctgaagacac agcgatgtac      420

tactgcgcgc gccaggacgg ttattaccct ggatggttcg ccaattgggg ccagggcacg      480

actgtgaccg tgagtagtgg aggcggcggg tcaggcggcg ggggctcggg gggcggcgga      540

tcggacatcg agctgacaca atcgcccgct atcatgagtg cctcgctcgg agaggagatc      600

accctgactt gttctgcctc cagctccgtc tcatacatgc actggtatca gcagaagagc      660

ggcacctccc ccaagctcct catctactcc acaagcaacc tggcgtccgg ggtgccgtcc      720

cgcttctctg gctcgggctc aggaaccttc tattcactca ccatctcttc cgtggaggct      780

gaagatgcag ccgactacta ctgccatcag tggtcgtcgt acactttcgg cggcgggacc      840

aagctagaga tcaagcgcac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      900

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      960

gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg     1020

acttgtgggg tccttctcct gtcactggtt atcacccttt actgccgggg cagaaagaaa     1080

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1140

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1200

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1260

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1320

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1380

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1440

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1500

cacatgcagg ccctgccccc tcgctaa                                         1527


<210>  160
<211>  810
<212>  DNA
<213>  artificial sequence

<220>
<223>  NY-ESO-1 TCR alpha chain

<400>  160
atggagaccc tgctcggggt ctcactggtc atcctgtggc tgcagctggc cagggtgaac       60

tcgcagcagg gggaggagga cccccaggcc ctgtccatcc aggaggggga gaatgccacc      120

atgaattgca gttacaagac ttccataaac aacctgcagt ggtaccgcca gaactccggc      180

cgcggcctgg tgcacctgat cctcatccgg tcgaatgaaa gggaaaagca ctcgggacgc      240

ctgcgagtga ctctggacac gtccaagaag tcgtccagtc tcttaatcac cgcctctcgc      300

gcagccgata ccgcatcgta cttctgtgca accgacgggg cgggcaagag tacattcggc      360

gacggcacta ccctgaccgt gaagccaaat atccagaagc ctgatccagc tgtctatcag      420

ttgcgcgatt ccaaatcgtc tgacaaatct gtgtgcctgt tcaccgactt cgactcccag      480

acgaacgtgt cccagagtaa agacagcgac gtgtacatca ctgataagac cgtgctggac      540

atgcgctcca tggactttaa aagtaacagc gctgtagcgt ggagcaacaa gagtgacttc      600

gcctgcgcca acgccttcaa taactctatc atacctgccg ataccttctt cccgagcccc      660

gaatccagtt gcgacgtgaa gctcgtggag aagagctttg agacagacac caacctgaac      720

ttccaaaacc tgtccgtcat tggcttcagg atcctcctcc tcaaggtggc cggcttcaac      780

ttgctcatga cgctgagact ctggagttca                                       810


<210>  161
<211>  927
<212>  DNA
<213>  artificial sequence

<220>
<223>  NY-ESO-1 beta chain

<400>  161
atggactcgt ggaccttatg ctgcgtgtcc ctgtgcatac tggttgccaa gcacacagac       60

gccggggtga tccagagccc ccggcacgaa gttaccgaga tgggccagga ggtgacgctc      120

cgatgcaagc ccatcagtgg ccacgattat ctcttctggt accgccaaac catgatgcgc      180

ggcttggaac tcctcatcta cttcaacaac aacgtcccca tcgatgactc cggcatgcct      240

gaggacaggt tcagtgcgaa gatgccgaat gcatccttct ccaccctgaa gatacagccg      300

agtgagcccc gcgactccgc tgtgtacttc tgcgcctcta ctatcggcgc ccagcctcaa      360

catttcggcg acggcacgcg cctcagtatc ctggaggacc tgaacaaggt gttccctccg      420

gaagtggctg tgtttgagcc ctccgaggca gaaatctcac acacacagaa ggcaaccctc      480

gtgtgtctgg caacaggttt cttcccagat cacgtggagc tgagttggtg ggtcaacggc      540

aaggaggtcc atagcggggt gagtaccgac ccacagcctc tcaaggagca gcctgccctc      600

aacgacagta ggtactgcct gtcctcgcgc ctccgcgtgt ccgcaacgtt ctggcagaat      660

ccccgcaacc acttccggtg ccaggtccaa ttctacggcc tgagtgagaa cgatgagtgg      720

acacaggata gggccaagcc cgtgacccag atcgtgtccg ccgaggcctg gggccgcgct      780

gactgcggct tcacctccgt gtcgtatcag cagggcgtat tatcagccac cattctttac      840

gaaatcctcc tcggcaaggc cacactatac gccgtgctgg tgtcggcgct ggtgttaatg      900

gcgatggtca agcgaaagga tttctaa                                          927


<210>  162
<211>  1818
<212>  DNA
<213>  artificial sequence

<220>
<223>  EBV16-E7 TCR

<400>  162
atgtggggcg tgttccttct ctacgtgtcg atgaagatgg gtggcaccac aggacagaat       60

atcgaccagc ccactgagat gaccgcaacc gagggagcga tcgtgcagat caactgcacc      120

taccagacat ccgggttcaa cgggctgttc tggtaccagc agcacgcagg ggaggcacct      180

accttcctgt cctacaatgt tctggacggc ctggaagaga aaggccgctt ctcttcattc      240

ctcagtcgct cgaagggcta ctcctacttg ctgctcaagg agttgcagat gaaggacagc      300

gcgtcctacc tctgcgcttc cgtggacggc aacaaccgtc tggcgttcgg caaaggcaac      360

caagtggtgg tgatcccgaa catccagaat cccgacccgg ctgtttacca gctgagagac      420

tccaaatcca gtgacaaatc tgtgtgtctg ttcaccgact tcgactccca aaccaacgtg      480

tctcagagta aggactctga cgtgtatatt acggataagt gcgtgctgga catgcgttca      540

atggacttca aaagcaattc cgccgtggca tggtccaaca agtcagactt cgcgtgtgcg      600

aacgccttca ataactcaat tatccccgag gataccttct tcccttcccc agagagctct      660

tgcgatgtta agctcgtcga gaagtcgttc gagactgata ccaacctgaa cttccagaac      720

ctgtcagtga tcggattccg tatactcctt ctgaaggtgg ccggcttcaa cctgctgatg      780

acactgagac tgtggagcag tcgagcgaag cgcgagggaa ggggcagtct gctcacctgc      840

ggcgacgtgg aggagaaccc cggccctatg ggccccggac tgctgtgctg ggcactcctg      900

tgcctgctcg gggccggcct cgtcgatgct ggcgtgaccc agtcgcccac ccacctaatc      960

aagacgagag gacagcaagt gacgcttagg tgctccccga agtcgggcca cgatacagtg     1020

agctggtacc agcaggccct ggggcagggc ccccaattca tcttccaata ctatgaggag     1080

gaagagcgcc agcgaggcaa cttccctgac cgattcagcg ggcatcagtt ccctaattac     1140

tcctcggagc tcaatgtgaa cgccctgctg ctcggagact cggcactgta cctctgcgct     1200

tccagtctgg ggtggcgggg cggaagatac aatgaacagt tcttcgggcc aggcacccgc     1260

ttgaccgtgc tggaggacct caagaacgtg ttccccccag aggtggctgt gttcgagccg     1320

tcggaggcgg agatctcgca tacccagaag gctaccctgg tgtgccttgc taccggattc     1380

tatccggatc atgtggagct atcatggtgg gtcaacggga aggaggtgca ctccggggtg     1440

tgcaccgatc cacaacccct gaaggaacag cccgcactga atgatagcag gtactgcctc     1500

tccagtcgcc tgcgggtgtc agcaacattc tggcagaacc cccgcaacca ctttcgctgt     1560

caggtgcaat tttacggtct gtccgagaac gacgaatgga ctcaggaccg tgccaaaccc     1620

gtgacacaga tcgtgtccgc agaagcgtgg ggccgtgccg actgcgggtt caccagcgag     1680

tcctaccagc agggcgtgct gtctgccact atcttgtacg agatcctcct gggcaaggca     1740

actctgtacg cagtactggt gtcggcgctg gtcctgatgg ccatggtgaa gcgtaaggac     1800

tctcgcgggt aataataa                                                   1818


<210>  163
<211>  1821
<212>  DNA
<213>  artificial sequence

<220>
<223>  H3.3K27M TCR

<400>  163
atgctgactg ccagcctgtt gagggcagtc atagcctcca tctgtgttgt atccagcatg       60

gctcagaagg taactcaagc gcagactgaa atttctgtgg tggagaagga ggatgtgacc      120

ttggactgtg tgtatgaaac ccgtgatact acttattact tattctggta caagcaacca      180

ccaagtggag aattggtttt ccttattcgt cggaactctt ttgatgagca aaatgaaata      240

agtggtcggt attcttggaa cttccagaaa tccaccagtt ccttcaactt caccatcaca      300

gcctcacaag tcgtggactc agcagtatac ttctgtgctc tgagtgagga gaatgacatg      360

cgctttggag cagggaccag actgacagta aaaccaaata tccagaaccc tgaccctgcc      420

gtgtaccagc tgagagactc taaatccagt gacaagtctg tctgcctatt caccgatttt      480

gattctcaaa caaatgtgtc acaaagtaag gattctgatg tgtatatcac agacaaaact      540

gtcctagaca tgaggtctat ggacttcaag agcaacagtg ctgtggcctg gagcaacaaa      600

tctgactttg catgtgcaaa cgccttcaac aacagcatta ttccagaaga caccttcttc      660

cccagcccag aaagttcctg tgatgtcaag ctggtcgaga aaagctttga aacagatacg      720

aacctaaact ttcaaaacct gtcagtgatt gggttccgaa tcctcctcct gaaagtggcc      780

ggatttaatc tgctcatgac gctgcggctg tggtccagcg tgaaacagac tttgaatttt      840

gaccttctca agttggcggg agacgtggag tccaacccag ggccgatggg cccccagctc      900

cttggctatg tggtcctttg ccttctagga gcaggccccc tggaagccca agtgacccag      960

aacccaagat acctcatcac agtgactgga aagaagttaa cagtgacttg ttctcagaat     1020

atgaaccatg agtatatgtc ctggtatcga caagacccag ggctgggctt aaggcagatc     1080

tactattcaa tgaatgttga ggtgactgat aagggagatg ttcctgaagg gtacaaagtc     1140

tctcgaaaag agaagaggaa tttccccctg atcctggagt cgcccaaccc caaccagacc     1200

tctctgtact tctgtgccag cggctggggt ggtccattct acgagcagta cttcgggccg     1260

ggcaccaggc tcacggtcac agaggacctg aaaaacgtgt tcccacccga ggtcgctgtg     1320

tttgagccat cagaagcaga gatctcccac acccaaaagg ccacactggt atgcctggcc     1380

acaggcttct accccgacca cgtggagctg agctggtggg tgaatgggaa ggaggtgcac     1440

agtggggtca gcacagaccc gcagcccctc aaggagcagc ccgccctcaa cgactccaga     1500

tactgcctga gcagccgcct gagggtctcg gccaccttct ggcagaaccc ccgcaaccac     1560

ttccgctgtc aagtccagtt ctacgggctc tcggagaacg acgagtggac ccaggatagg     1620

gccaaacccg tcacccagat cgtcagcgcc gaggcctggg gtagagcaga ctgtggcttc     1680

acctccgagt cttaccagca aggggtcctg tctgccacca tcctctatga gatcttgcta     1740

gggaaggcca ccttgtatgc cgtgctggtc agtgccctcg tgctgatggc catggtcaag     1800

agaaaggatt ccagaggcta g                                               1821


<210>  164
<211>  1605
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD19-CD3 BiTE

<400>  164
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactccgac       60

tacaaagatg atgacgataa ggatatccag ctgacccagt ctccagcttc tttggctgtg      120

tctctagggc agagggccac catctcctgc aaggccagcc aaagtgttga ttatgatggt      180

gatagttatt tgaactggta ccaacagatt ccaggacagc cacccaaact cctcatctat      240

gatgcatcca atctagtttc tgggatccca cccaggttta gtggcagtgg gtctgggaca      300

gacttcaccc tcaacatcca tcctgtggag aaggtggatg ctgcaaccta tcactgtcag      360

caaagtactg aggatccgtg gacgttcggt ggagggacca agctcgagat caaaggtggt      420

ggtggttctg gcggcggcgg ctccggtggt ggtggttctc aggtgcagct gcagcagtct      480

ggggctgagc tggtgaggcc tgggtcctca gtgaagattt cctgcaaggc ttctggctat      540

gcattcagta gctactggat gaactgggtg aagcagaggc ctggacaggg tcttgagtgg      600

attggacaga tttggcctgg agatggtgat actaactaca atggaaagtt caagggtaaa      660

gccactctga ctgcagacga atcctccagc acagcctaca tgcaactcag cagcctagca      720

tctgaggact ctgcggtcta tttctgtgca agacgggaga ctacgacggt aggccgttat      780

tactatgcta tggactactg gggccaaggg accacggtca ccgtctcctc cggaggtggt      840

ggatccgata tcaaactgca gcagtcaggg gctgaactgg caagacctgg ggcctcagtg      900

aagatgtcct gcaagacttc tggctacacc tttactaggt acacgatgca ctgggtaaaa      960

cagaggcctg gacagggtct ggaatggatt ggatacatta atcctagccg tggttatact     1020

aattacaatc agaagttcaa ggacaaggcc acattgacta cagacaaatc ctccagcaca     1080

gcctacatgc aactgagcag cctgacatct gaggactctg cggtctattt ctgtgcaaga     1140

tattatgatg atcattactg ccttgactac tggggccaag gcaccactct cacagtctcc     1200

tcagtcgaag gtggaagtgg aggttctggt ggaagtggag gttcaggtgg agtcgacgac     1260

gccgccattc agctgaccca gtctccagca atcatgtctg catctccagg ggagaaggtc     1320

accatgacct gcagagccag ttcaagtgta agttacatga actggtacca gcagaagtca     1380

ggcacctccc ccaaaagatg gatttatgac acatccaaag tggcttctgg agtcccttat     1440

cgcttcagtg gcagtgggtc tgggacctca tactctctca caatcagcag catggaggct     1500

gaagatgctg ccacttatta ctgccaacag tggagtagta acccgctcac gttcggtgct     1560

gggaccaagc tggagctgaa acatcatcac catcatcatt aataa                     1605


<210>  165
<211>  1569
<212>  DNA
<213>  artificial sequence

<220>
<223>  139-CD3 (EGFRvIII BiTE)

<400>  165
atgggctgga gctgtatcat tctgttcctg gtggccacag ccactggcgt gcattcggat       60

tacaaggatg acgatgacaa ggatatccag atgacccaga gtccatcgtc cctgtccgcc      120

tcggtgggag accgggtgac catcacttgc agagcatccc aaggcatccg caacaacctc      180

gcctggtacc agcagaagcc cggcaaggcc cccaagaggc tgatctatgc ggcatccaac      240

ctgcagtccg gcgtcccaag tcgcttcaca ggctcgggtt ccggcacaga gttcacttta      300

atcgtgtcct cgctgcagcc agaggacttt gcaacatact actgcctgca gcaccactcg      360

tatcccctga cctcgggcgg cgggaccaag gtggagatca agggaggtgg cgggtctggt      420

ggcggaggtt ccggcggcgg gggctccgag gtacaggtac tcgagagtgg tgggggcctg      480

gtgcagcccg ggggctccct tagactctcg tgcgcggcca gcggattcac cttcagttcc      540

tacgccatgt catgggtgcg acaggcgccc ggcaagggtc tcgagtgggt atcggccatt      600

tcgggctccg gcgggtcgac caactacgcc gatagtgtga agggccgttt caccatctcc      660

cgggacaaca gtaagaacac cctctacctg cagatgaaca gtctgagagc ggaggacacc      720

gcagtgtact actgcgccgg ctcctcgggg tggtccgagt actggggcca gggcaccctg      780

gtgactgtgt ctagcggagg tggtggatcc gatatcaaac tgcagcagtc aggggctgaa      840

ctggcaagac ctggggcctc agtgaagatg tcctgcaaga cttctggcta cacctttact      900

aggtacacga tgcactgggt aaaacagagg cctggacagg gtctggaatg gattggatac      960

attaatccta gccgtggtta tactaattac aatcagaagt tcaaggacaa ggccacattg     1020

actacagaca aatcctccag cacagcctac atgcaactga gcagcctgac atctgaggac     1080

tctgcagtct attactgtgc aagatattat gatgatcatt actgccttga ctactggggc     1140

caaggcacca ctctcacagt ctcctcagtc gaaggtggaa gtggaggttc tggtggaagt     1200

ggaggttcag gtggagtcga cgacgccgcc attcagctga cccagtctcc agcaatcatg     1260

tctgcatctc caggggagaa ggtcaccatg acctgcagag ccagttcaag tgtaagttac     1320

atgaactggt accagcagaa gtcaggcacc tcccccaaaa gatggattta tgacacatcc     1380

aaagtggctt ctggagtccc ttatcgcttc agtggcagtg ggtctgggac ctcatactct     1440

ctcacaatca gcagcatgga ggctgaagat gctgccactt attactgcca acagtggagt     1500

agtaacccgc tcacgttcgg tgctgggacc aagctggagc tgaaacatca tcaccatcat     1560

cattaataa                                                             1569


<210>  166
<211>  277
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CD40

<400>  166

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  167
<211>  357
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human RAP1

<400>  167

Met Ala Pro Arg Arg Val Arg Ser Phe Leu Arg Gly Leu Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Phe Leu Gly Pro Trp Pro Ala Ala Ser His Gly 
            20                  25                  30          


Gly Lys Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg 
        35                  40                  45              


Glu Ser Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu 
    50                  55                  60                  


Lys Ala Gln Arg Leu His Leu Pro Pro Val Arg Leu Ala Glu Leu His 
65                  70                  75                  80  


Ala Asp Leu Lys Ile Gln Glu Arg Asp Glu Leu Ala Trp Lys Lys Leu 
                85                  90                  95      


Lys Leu Asp Gly Leu Asp Glu Asp Gly Glu Lys Glu Ala Arg Leu Ile 
            100                 105                 110         


Arg Asn Leu Asn Val Ile Leu Ala Lys Tyr Gly Leu Asp Gly Lys Lys 
        115                 120                 125             


Asp Ala Arg Gln Val Thr Ser Asn Ser Leu Ser Gly Thr Gln Glu Asp 
    130                 135                 140                 


Gly Leu Asp Asp Pro Arg Leu Glu Lys Leu Trp His Lys Ala Lys Thr 
145                 150                 155                 160 


Ser Gly Lys Phe Ser Gly Glu Glu Leu Asp Lys Leu Trp Arg Glu Phe 
                165                 170                 175     


Leu His His Lys Glu Lys Val His Glu Tyr Asn Val Leu Leu Glu Thr 
            180                 185                 190         


Leu Ser Arg Thr Glu Glu Ile His Glu Asn Val Ile Ser Pro Ser Asp 
        195                 200                 205             


Leu Ser Asp Ile Lys Gly Ser Val Leu His Ser Arg His Thr Glu Leu 
    210                 215                 220                 


Lys Glu Lys Leu Arg Ser Ile Asn Gln Gly Leu Asp Arg Leu Arg Arg 
225                 230                 235                 240 


Val Ser His Gln Gly Tyr Ser Thr Glu Ala Glu Phe Glu Glu Pro Arg 
                245                 250                 255     


Val Ile Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Leu Thr Asp Lys 
            260                 265                 270         


Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala Lys Ile 
        275                 280                 285             


Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His Glu Lys 
    290                 295                 300                 


Leu Arg His Ala Glu Ser Val Gly Asp Gly Glu Arg Val Ser Arg Ser 
305                 310                 315                 320 


Arg Glu Lys His Ala Leu Leu Glu Gly Arg Thr Lys Glu Leu Gly Tyr 
                325                 330                 335     


Thr Val Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser Arg Ala 
            340                 345                 350         


Arg His Asn Glu Leu 
        355         


<210>  168
<211>  105
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human RAP1 Domain 3

<400>  168

Ser Arg His Thr Glu Leu Lys Glu Lys Leu Arg Ser Ile Asn Gln Gly 
1               5                   10                  15      


Leu Asp Arg Leu Arg Arg Val Ser His Gln Gly Tyr Ser Thr Glu Ala 
            20                  25                  30          


Glu Phe Glu Glu Pro Arg Val Ile Asp Leu Trp Asp Leu Ala Gln Ser 
        35                  40                  45              


Ala Asn Leu Thr Asp Lys Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys 
    50                  55                  60                  


His Phe Glu Ala Lys Ile Glu Lys His Asn His Tyr Gln Lys Gln Leu 
65                  70                  75                  80  


Glu Ile Ala His Glu Lys Leu Arg His Ala Glu Ser Val Gly Asp Gly 
                85                  90                  95      


Glu Arg Val Ser Arg Ser Arg Glu Lys 
            100                 105 


<210>  169
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human ICAM2

<400>  169

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  170
<211>  547
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human ICAM3

<400>  170

Met Ala Thr Met Val Pro Ser Val Leu Trp Pro Arg Ala Cys Trp Thr 
1               5                   10                  15      


Leu Leu Val Cys Cys Leu Leu Thr Pro Gly Val Gln Gly Gln Glu Phe 
            20                  25                  30          


Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser 
        35                  40                  45              


Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile Ala 
    50                  55                  60                  


Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly Met Gly Trp 
65                  70                  75                  80  


Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg Ile Leu Cys 
                85                  90                  95      


Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser Asn Ile Thr 
            100                 105                 110         


Val Tyr Arg Leu Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Pro Trp 
        115                 120                 125             


Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val Glu Asp Gly 
    130                 135                 140                 


Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp Glu Glu Glu 
145                 150                 155                 160 


Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val Thr Ala Thr 
                165                 170                 175     


Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser Cys Arg Thr 
            180                 185                 190         


Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn Thr Ser 
        195                 200                 205             


Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Val Thr Pro Pro Arg 
    210                 215                 220                 


Leu Val Ala Pro Arg Phe Leu Glu Val Glu Thr Ser Trp Pro Val Asp 
225                 230                 235                 240 


Cys Thr Leu Asp Gly Leu Phe Pro Ala Ser Glu Ala Gln Val Tyr Leu 
                245                 250                 255     


Ala Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn His Gly Asp 
            260                 265                 270         


Thr Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala Asp Gln Glu Gly 
        275                 280                 285             


Ala Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu Arg Arg Glu 
    290                 295                 300                 


Ala Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro Ile Val Asn 
305                 310                 315                 320 


Leu Ser Glu Pro Thr Ala His Glu Gly Ser Thr Val Thr Val Ser Cys 
                325                 330                 335     


Met Ala Gly Ala Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala 
            340                 345                 350         


Ala Pro Gly Gln Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp 
        355                 360                 365             


Asp Gly Arg Ser Phe Phe Cys Ser Ala Thr Leu Glu Val Asp Gly Glu 
    370                 375                 380                 


Phe Leu His Arg Asn Ser Ser Val Gln Leu Arg Val Leu Tyr Gly Pro 
385                 390                 395                 400 


Lys Ile Asp Arg Ala Thr Cys Pro Gln His Leu Lys Trp Lys Asp Lys 
                405                 410                 415     


Thr Arg His Val Leu Gln Cys Gln Ala Arg Gly Asn Pro Tyr Pro Glu 
            420                 425                 430         


Leu Arg Cys Leu Lys Glu Gly Ser Ser Arg Glu Val Pro Val Gly Ile 
        435                 440                 445             


Pro Phe Phe Val Asn Val Thr His Asn Gly Thr Tyr Gln Cys Gln Ala 
    450                 455                 460                 


Ser Ser Ser Arg Gly Lys Tyr Thr Leu Val Val Val Met Asp Ile Glu 
465                 470                 475                 480 


Ala Gly Ser Ser His Phe Val Pro Val Phe Val Ala Val Leu Leu Thr 
                485                 490                 495     


Leu Gly Val Val Thr Ile Val Leu Ala Leu Met Tyr Val Phe Arg Glu 
            500                 505                 510         


His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr Tyr Leu 
        515                 520                 525             


Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu Pro Ser 
    530                 535                 540                 


Arg Ala Glu 
545         


<210>  171
<211>  769
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CD18

<400>  171

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val Gln Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  172
<211>  468
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human CEACAM1

<400>  172

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Thr Thr Pro Met Thr 
    450                 455                 460                 


His Leu Thr Arg 
465             


<210>  173
<211>  164
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD3zeta polypeptide

<400>  173

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  174
<211>  86
<212>  PRT
<213>  artificial sequence

<220>
<223>  FcRgamma polypeptide

<400>  174

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  175
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  DAP12

<400>  175

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  176
<211>  235
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD8

<400>  176

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  177
<211>  458
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD4

<400>  177

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  178
<211>  250
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD58

<400>  178

Met Val Ala Gly Ser Asp Ala Gly Arg Ala Leu Gly Val Leu Ser Val 
1               5                   10                  15      


Val Cys Leu Leu His Cys Phe Gly Phe Ile Ser Cys Phe Ser Gln Gln 
            20                  25                  30          


Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val Pro Ser Asn 
        35                  40                  45              


Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp Lys Val Ala 
    50                  55                  60                  


Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe Lys Asn Arg 
65                  70                  75                  80  


Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu Thr 
                85                  90                  95      


Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr Asp 
            100                 105                 110         


Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Leu Pro Ser Pro Thr 
        115                 120                 125             


Leu Thr Cys Ala Leu Thr Asn Gly Ser Ile Glu Val Gln Cys Met Ile 
    130                 135                 140                 


Pro Glu His Tyr Asn Ser His Arg Gly Leu Ile Met Tyr Ser Trp Asp 
145                 150                 155                 160 


Cys Pro Met Glu Gln Cys Lys Arg Asn Ser Thr Ser Ile Tyr Phe Lys 
                165                 170                 175     


Met Glu Asn Asp Leu Pro Gln Lys Ile Gln Cys Thr Leu Ser Asn Pro 
            180                 185                 190         


Leu Phe Asn Thr Thr Ser Ser Ile Ile Leu Thr Thr Cys Ile Pro Ser 
        195                 200                 205             


Ser Gly His Ser Arg His Arg Tyr Ala Leu Ile Pro Ile Pro Leu Ala 
    210                 215                 220                 


Val Ile Thr Thr Cys Ile Val Leu Tyr Met Asn Gly Ile Leu Lys Cys 
225                 230                 235                 240 


Asp Arg Lys Pro Asp Arg Thr Asn Ser Asn 
                245                 250 


<210>  179
<211>  193
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD70

<400>  179

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  180
<211>  205
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD83

<400>  180

Met Ser Arg Gly Leu Gln Leu Leu Leu Leu Ser Cys Ala Tyr Ser Leu 
1               5                   10                  15      


Ala Pro Ala Thr Pro Glu Val Lys Val Ala Cys Ser Glu Asp Val Asp 
            20                  25                  30          


Leu Pro Cys Thr Ala Pro Trp Asp Pro Gln Val Pro Tyr Thr Val Ser 
        35                  40                  45              


Trp Val Lys Leu Leu Glu Gly Gly Glu Glu Arg Met Glu Thr Pro Gln 
    50                  55                  60                  


Glu Asp His Leu Arg Gly Gln His Tyr His Gln Lys Gly Gln Asn Gly 
65                  70                  75                  80  


Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser Leu Lys Ile Arg Asn 
                85                  90                  95      


Thr Thr Ser Cys Asn Ser Gly Thr Tyr Arg Cys Thr Leu Gln Asp Pro 
            100                 105                 110         


Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile Leu Arg Val Thr Gly 
        115                 120                 125             


Cys Pro Ala Gln Arg Lys Glu Glu Thr Phe Lys Lys Tyr Arg Ala Glu 
    130                 135                 140                 


Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr Leu Thr Leu Ile Ile 
145                 150                 155                 160 


Phe Thr Cys Lys Phe Ala Arg Leu Gln Ser Ile Phe Pro Asp Phe Ser 
                165                 170                 175     


Lys Ala Gly Met Glu Arg Ala Phe Leu Pro Val Thr Ser Pro Asn Lys 
            180                 185                 190         


His Leu Gly Leu Val Thr Pro His Lys Thr Glu Leu Val 
        195                 200                 205 


<210>  181
<211>  254
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD137L

<400>  181

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  182
<211>  183
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD252

<400>  182

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  183
<211>  302
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD275

<400>  183

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
    290                 295                 300         


<210>  184
<211>  532
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD54

<400>  184

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  185
<211>  1179
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD49a

<400>  185

Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15      


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30          


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45              


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60                  


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80  


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95      


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110         


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125             


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140                 


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160 


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175     


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190         


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205             


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220                 


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240 


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255     


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270         


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285             


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300                 


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320 


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335     


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350         


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365             


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380                 


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400 


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415     


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430         


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445             


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460                 


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480 


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495     


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510         


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525             


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540                 


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560 


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575     


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590         


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605             


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620                 


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640 


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655     


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670         


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685             


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700                 


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720 


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735     


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750         


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Asp Lys His Asp 
        755                 760                 765             


Phe Gln Asp Ser Val Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro 
    770                 775                 780                 


Glu Asn Gly Pro Val Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu 
785                 790                 795                 800 


Tyr Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Lys Cys Ile Ser 
                805                 810                 815     


Asp Leu Ser Leu His Val Ala Thr Thr Glu Lys Asp Leu Leu Ile Val 
            820                 825                 830         


Arg Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Thr 
        835                 840                 845             


Lys Asp Ser Ala Tyr Asn Thr Arg Thr Ile Val His Tyr Ser Pro Asn 
    850                 855                 860                 


Leu Val Phe Ser Gly Ile Glu Ala Ile Gln Lys Asp Ser Cys Glu Ser 
865                 870                 875                 880 


Asn His Asn Ile Thr Cys Lys Val Gly Tyr Pro Phe Leu Arg Arg Gly 
                885                 890                 895     


Glu Met Val Thr Phe Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu 
            900                 905                 910         


Met Glu Asn Val Thr Ile Tyr Leu Ser Ala Thr Ser Asp Ser Glu Glu 
        915                 920                 925             


Pro Pro Glu Thr Leu Ser Asp Asn Val Val Asn Ile Ser Ile Pro Val 
    930                 935                 940                 


Lys Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu Tyr His 
945                 950                 955                 960 


Ile Ser Ile Ala Ala Asn Glu Thr Val Pro Glu Val Ile Asn Ser Thr 
                965                 970                 975     


Glu Asp Ile Gly Asn Glu Ile Asn Ile Phe Tyr Leu Ile Arg Lys Ser 
            980                 985                 990         


Gly Ser Phe Pro Met Pro Glu Leu  Lys Leu Ser Ile Ser  Phe Pro Asn 
        995                 1000                 1005             


Met Thr  Ser Asn Gly Tyr Pro  Val Leu Tyr Pro Thr  Gly Leu Ser 
    1010                 1015                 1020             


Ser Ser  Glu Asn Ala Asn Cys  Arg Pro His Ile Phe  Glu Asp Pro 
    1025                 1030                 1035             


Phe Ser  Ile Asn Ser Gly Lys  Lys Met Thr Thr Ser  Thr Asp His 
    1040                 1045                 1050             


Leu Lys  Arg Gly Thr Ile Leu  Asp Cys Asn Thr Cys  Lys Phe Ala 
    1055                 1060                 1065             


Thr Ile  Thr Cys Asn Leu Thr  Ser Ser Asp Ile Ser  Gln Val Asn 
    1070                 1075                 1080             


Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ser Tyr Phe 
    1085                 1090                 1095             


Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Arg  Ser Glu Asn 
    1100                 1105                 1110             


Ala Ser  Leu Val Leu Ser Ser  Ser Asn Gln Lys Arg  Glu Leu Ala 
    1115                 1120                 1125             


Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp 
    1130                 1135                 1140             


Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu 
    1145                 1150                 1155             


Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu 
    1160                 1165                 1170             


Lys Lys  Lys Met Glu Lys 
    1175                 


<210>  186
<211>  538
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD112

<400>  186

Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr 
            340                 345                 350         


Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala 
        355                 360                 365             


Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln 
    370                 375                 380                 


Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu 
                405                 410                 415     


Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His 
            420                 425                 430         


Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu 
        435                 440                 445             


Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser 
    450                 455                 460                 


Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val 
465                 470                 475                 480 


Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp 
                485                 490                 495     


Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile 
            500                 505                 510         


Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys 
        515                 520                 525             


Gly Phe Val Met Ser Arg Ala Met Tyr Val 
    530                 535             


<210>  187
<211>  335
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD150

<400>  187

Met Asp Pro Lys Gly Leu Leu Ser Leu Thr Phe Val Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Gly Ala Ser Tyr Gly Thr Gly Gly Arg Met Met Asn Cys 
            20                  25                  30          


Pro Lys Ile Leu Arg Gln Leu Gly Ser Lys Val Leu Leu Pro Leu Thr 
        35                  40                  45              


Tyr Glu Arg Ile Asn Lys Ser Met Asn Lys Ser Ile His Ile Val Val 
    50                  55                  60                  


Thr Met Ala Lys Ser Leu Glu Asn Ser Val Glu Asn Lys Ile Val Ser 
65                  70                  75                  80  


Leu Asp Pro Ser Glu Ala Gly Pro Pro Arg Tyr Leu Gly Asp Arg Tyr 
                85                  90                  95      


Lys Phe Tyr Leu Glu Asn Leu Thr Leu Gly Ile Arg Glu Ser Arg Lys 
            100                 105                 110         


Glu Asp Glu Gly Trp Tyr Leu Met Thr Leu Glu Lys Asn Val Ser Val 
        115                 120                 125             


Gln Arg Phe Cys Leu Gln Leu Arg Leu Tyr Glu Gln Val Ser Thr Pro 
    130                 135                 140                 


Glu Ile Lys Val Leu Asn Lys Thr Gln Glu Asn Gly Thr Cys Thr Leu 
145                 150                 155                 160 


Ile Leu Gly Cys Thr Val Glu Lys Gly Asp His Val Ala Tyr Ser Trp 
                165                 170                 175     


Ser Glu Lys Ala Gly Thr His Pro Leu Asn Pro Ala Asn Ser Ser His 
            180                 185                 190         


Leu Leu Ser Leu Thr Leu Gly Pro Gln His Ala Asp Asn Ile Tyr Ile 
        195                 200                 205             


Cys Thr Val Ser Asn Pro Ile Ser Asn Asn Ser Gln Thr Phe Ser Pro 
    210                 215                 220                 


Trp Pro Gly Cys Arg Thr Asp Pro Ser Glu Thr Lys Pro Trp Ala Val 
225                 230                 235                 240 


Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile Met Val Val 
                245                 250                 255     


Ile Leu Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr 
            260                 265                 270         


Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly 
        275                 280                 285             


Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr 
    290                 295                 300                 


Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu 
305                 310                 315                 320 


Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 
                325                 330                 335 


<210>  188
<211>  417
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD155

<400>  188

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Met Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210>  189
<211>  616
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD265

<400>  189

Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile Ala Pro 
            20                  25                  30          


Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg Cys Cys Asn 
        35                  40                  45              


Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys Thr Thr Thr Ser 
    50                  55                  60                  


Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu Tyr Leu Asp Ser Trp 
65                  70                  75                  80  


Asn Glu Glu Asp Lys Cys Leu Leu His Lys Val Cys Asp Thr Gly Lys 
                85                  90                  95      


Ala Leu Val Ala Val Val Ala Gly Asn Ser Thr Thr Pro Arg Arg Cys 
            100                 105                 110         


Ala Cys Thr Ala Gly Tyr His Trp Ser Gln Asp Cys Glu Cys Cys Arg 
        115                 120                 125             


Arg Asn Thr Glu Cys Ala Pro Gly Leu Gly Ala Gln His Pro Leu Gln 
    130                 135                 140                 


Leu Asn Lys Asp Thr Val Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser 
145                 150                 155                 160 


Asp Ala Phe Ser Ser Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr 
                165                 170                 175     


Phe Leu Gly Lys Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala 
            180                 185                 190         


Val Cys Ser Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His 
        195                 200                 205             


Val Tyr Leu Pro Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala 
    210                 215                 220                 


Leu Val Ala Ala Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys 
225                 230                 235                 240 


Ala Leu Thr Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg 
                245                 250                 255     


Leu Ser Gly Asp Lys Glu Ser Ser Gly Asp Ser Cys Val Ser Thr His 
            260                 265                 270         


Thr Ala Asn Phe Gly Gln Gln Gly Ala Cys Glu Gly Val Leu Leu Leu 
        275                 280                 285             


Thr Leu Glu Glu Lys Thr Phe Pro Glu Asp Met Cys Tyr Pro Asp Gln 
    290                 295                 300                 


Gly Gly Val Cys Gln Gly Thr Cys Val Gly Gly Gly Pro Tyr Ala Gln 
305                 310                 315                 320 


Gly Glu Asp Ala Arg Met Leu Ser Leu Val Ser Lys Thr Glu Ile Glu 
                325                 330                 335     


Glu Asp Ser Phe Arg Gln Met Pro Thr Glu Asp Glu Tyr Met Asp Arg 
            340                 345                 350         


Pro Ser Gln Pro Thr Asp Gln Leu Leu Phe Leu Thr Glu Pro Gly Ser 
        355                 360                 365             


Lys Ser Thr Pro Pro Phe Ser Glu Pro Leu Glu Val Gly Glu Asn Asp 
    370                 375                 380                 


Ser Leu Ser Gln Cys Phe Thr Gly Thr Gln Ser Thr Val Gly Ser Glu 
385                 390                 395                 400 


Ser Cys Asn Cys Thr Glu Pro Leu Cys Arg Thr Asp Trp Thr Pro Met 
                405                 410                 415     


Ser Ser Glu Asn Tyr Leu Gln Lys Glu Val Asp Ser Gly His Cys Pro 
            420                 425                 430         


His Trp Ala Ala Ser Pro Ser Pro Asn Trp Ala Asp Val Cys Thr Gly 
        435                 440                 445             


Cys Arg Asn Pro Pro Gly Glu Asp Cys Glu Pro Leu Val Gly Ser Pro 
    450                 455                 460                 


Lys Arg Gly Pro Leu Pro Gln Cys Ala Tyr Gly Met Gly Leu Pro Pro 
465                 470                 475                 480 


Glu Glu Glu Ala Ser Arg Thr Glu Ala Arg Asp Gln Pro Glu Asp Gly 
                485                 490                 495     


Ala Asp Gly Arg Leu Pro Ser Ser Ala Arg Ala Gly Ala Gly Ser Gly 
            500                 505                 510         


Ser Ser Pro Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn 
        515                 520                 525             


Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys Gly 
    530                 535                 540                 


Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly Ala Ala 
545                 550                 555                 560 


Ala Ala Ala Glu Pro Met Gly Arg Pro Val Gln Glu Glu Thr Leu Ala 
                565                 570                 575     


Arg Arg Asp Ser Phe Ala Gly Asn Gly Pro Arg Phe Pro Asp Pro Cys 
            580                 585                 590         


Gly Gly Pro Glu Gly Leu Arg Glu Pro Glu Lys Ala Ser Arg Pro Val 
        595                 600                 605             


Gln Glu Gln Gly Gly Ala Lys Ala 
    610                 615     


<210>  190
<211>  283
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD270

<400>  190

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  191
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  TL1A

<400>  191

Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210>  192
<211>  459
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD127

<400>  192

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  193
<211>  825
<212>  PRT
<213>  artificial sequence

<220>
<223>  IL-4R

<400>  193

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  194
<211>  199
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR-L

<400>  194

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210>  195
<211>  378
<212>  PRT
<213>  artificial sequence

<220>
<223>  TIM-4

<400>  195

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Leu 
                325                 330                 335     


Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu 
            340                 345                 350         


Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly 
        355                 360                 365             


Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
    370                 375             


<210>  196
<211>  234
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD153

<400>  196

Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210>  197
<211>  325
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD200R

<400>  197

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys 
            20                  25                  30          


Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser 
        35                  40                  45              


Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile 
    50                  55                  60                  


Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly 
65                  70                  75                  80  


Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr Asn Glu Thr Lys 
                85                  90                  95      


Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp 
            100                 105                 110         


Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile Thr His Asp Gly 
        115                 120                 125             


Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly 
    130                 135                 140                 


Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn 
145                 150                 155                 160 


Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala 
                165                 170                 175     


Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr 
            180                 185                 190         


Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val 
        195                 200                 205             


His Asn Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn 
    210                 215                 220                 


Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser 
225                 230                 235                 240 


Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile Ile Ile Leu Thr 
                245                 250                 255     


Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly Cys Arg Lys Tyr 
            260                 265                 270         


Lys Leu Asn Lys Thr Glu Ser Thr Pro Val Val Glu Glu Asp Glu Met 
        275                 280                 285             


Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn Asn Pro Leu Tyr Asp Thr 
    290                 295                 300                 


Thr Asn Lys Val Lys Ala Ser Glu Ala Leu Gln Ser Glu Val Asp Thr 
305                 310                 315                 320 


Asp Leu His Thr Leu 
                325 


<210>  198
<211>  742
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD44

<400>  198

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  199
<211>  595
<212>  PRT
<213>  artificial sequence

<220>
<223>  TriCD40L_8-28 AA

<400>  199

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu 
            20                  25                  30          


Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr 
        35                  40                  45              


Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu 
    50                  55                  60                  


Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe 
65                  70                  75                  80  


Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu 
                85                  90                  95      


Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala 
            100                 105                 110         


Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu 
        115                 120                 125             


Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val 
    130                 135                 140                 


Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly 
145                 150                 155                 160 


Leu Leu Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Ser Asn Pro Gln 
                165                 170                 175     


Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val 
            180                 185                 190         


Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val 
        195                 200                 205             


Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr 
    210                 215                 220                 


Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser 
225                 230                 235                 240 


Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe 
                245                 250                 255     


Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro 
            260                 265                 270         


Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro 
        275                 280                 285             


Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His 
    290                 295                 300                 


Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Ser Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu 
                325                 330                 335     


Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr 
            340                 345                 350         


Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu 
        355                 360                 365             


Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe 
    370                 375                 380                 


Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu 
385                 390                 395                 400 


Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala 
                405                 410                 415     


Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu 
            420                 425                 430         


Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val 
        435                 440                 445             


Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly 
    450                 455                 460                 


Leu Leu Lys Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                485                 490                 495     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            500                 505                 510         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        515                 520                 525             


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
    530                 535                 540                 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
545                 550                 555                 560 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                565                 570                 575     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            580                 585                 590         


Tyr Arg Ser 
        595 


<210>  200
<211>  1788
<212>  DNA
<213>  artificial sequence

<220>
<223>  TriCD40L_8-28 NT

<400>  200
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgaatcctc aaattgcggc acatgtcata agtgaggcca gcagtaaaac aacatctgtg      120

ttacagtggg ctgaaaaagg atactacacc atgagcaaca acttggtaac cctggaaaat      180

gggaaacagc tgaccgttaa aagacaagga ctctattata tctatgccca agtcaccttc      240

tgttccaatc gggaagcttc gagtcaagct ccatttatag ccagcctctg cctaaagtcc      300

cccggtagat tcgagagaat cttactcaga gctgcaaata cccacagttc cgccaaacct      360

tgcgggcaac aatccattca cttgggagga gtatttgaat tgcaaccagg tgcttcggtg      420

tttgtcaatg tgactgatcc aagccaagtg agccatggca ctggcttcac gtcctttggc      480

ttactcaaac tcggcggggg cggttctggg ggtggcagta atccccagat cgccgcacac      540

gtgatctccg aggctagctc taagaccacc agtgtgctgc agtgggccga aaagggatac      600

tatacaatga gcaataacct ggtgacactg gagaacggca aacagctcac cgtgaagagg      660

caaggtctgt actacatcta cgctcaggtc accttctgca gcaatcgaga agcaagtagt      720

caggcgccct tcattgccag tttatgtcta aagagcccag gccgctttga gcgtatcctc      780

ctccgcgccg ctaatacgca ctccagcgca aaaccctgtg gccagcagtc aatccacctc      840

ggcggggtgt tcgaactgca acctggcgct tccgtgttcg tgaatgtgac cgatccctca      900

caggtcagcc acggcacggg cttcacctcg ttcgggctgc tgaagctggg gggcggcggc      960

agtggcgggg ggagtaaccc ccagatcgcc gcacacgtga ttagtgaggc gtcctccaag     1020

acaacctccg tgctgcagtg ggccgagaag ggctactaca ccatgagtaa caacctcgta     1080

accctggaga acggaaagca gttaaccgtc aagcgccagg gcctgtacta catctacgcg     1140

caggtcacat tctgctcaaa cagggaggcc tcgtcccagg ccccctttat cgcttccctg     1200

tgcctgaagt ctccgggacg cttcgaacga atcctgctgc gtgcggccaa cacgcactcg     1260

tccgccaaac cgtgtggcca gcagtccata cacctcggcg gcgtgttcga gctgcaacct     1320

ggcgccagcg tgttcgtgaa cgtgacagac ccctcccagg tctcccacgg gacaggtttt     1380

accagtttcg gcctgcttaa gctcggatcc gggggcggcg gttccggcgg ggggggctct     1440

gggggcggcg gctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc     1500

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg     1560

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact     1620

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggagtaa gaggagcagg     1680

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat     1740

taccagccct atgccccacc acgcgacttc gcagcctatc gctcctaa                  1788


<210>  201
<211>  592
<212>  PRT
<213>  artificial sequence

<220>
<223>  TriCD40L_28-28 AA

<400>  201

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu 
            20                  25                  30          


Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr 
        35                  40                  45              


Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu 
    50                  55                  60                  


Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe 
65                  70                  75                  80  


Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu 
                85                  90                  95      


Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala 
            100                 105                 110         


Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu 
        115                 120                 125             


Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val 
    130                 135                 140                 


Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly 
145                 150                 155                 160 


Leu Leu Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Ser Asn Pro Gln 
                165                 170                 175     


Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val 
            180                 185                 190         


Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val 
        195                 200                 205             


Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr 
    210                 215                 220                 


Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser 
225                 230                 235                 240 


Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe 
                245                 250                 255     


Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro 
            260                 265                 270         


Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro 
        275                 280                 285             


Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His 
    290                 295                 300                 


Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Ser Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu 
                325                 330                 335     


Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr 
            340                 345                 350         


Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu 
        355                 360                 365             


Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe 
    370                 375                 380                 


Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu 
385                 390                 395                 400 


Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala 
                405                 410                 415     


Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu 
            420                 425                 430         


Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val 
        435                 440                 445             


Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly 
    450                 455                 460                 


Leu Leu Lys Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
                485                 490                 495     


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
            500                 505                 510         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        515                 520                 525             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    530                 535                 540                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
545                 550                 555                 560 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                565                 570                 575     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            580                 585                 590         


<210>  202
<211>  1779
<212>  DNA
<213>  artificial sequence

<220>
<223>  TriCD40L_28-28 NT

<400>  202
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgaatcctc aaattgcggc acatgtcata agtgaggcca gcagtaaaac aacatctgtg      120

ttacagtggg ctgaaaaagg atactacacc atgagcaaca acttggtaac cctggaaaat      180

gggaaacagc tgaccgttaa aagacaagga ctctattata tctatgccca agtcaccttc      240

tgttccaatc gggaagcttc gagtcaagct ccatttatag ccagcctctg cctaaagtcc      300

cccggtagat tcgagagaat cttactcaga gctgcaaata cccacagttc cgccaaacct      360

tgcgggcaac aatccattca cttgggagga gtatttgaat tgcaaccagg tgcttcggtg      420

tttgtcaatg tgactgatcc aagccaagtg agccatggca ctggcttcac gtcctttggc      480

ttactcaaac tcggcggggg cggttctggg ggtggcagta atccccagat cgccgcacac      540

gtgatctccg aggctagctc taagaccacc agtgtgctgc agtgggccga aaagggatac      600

tatacaatga gcaataacct ggtgacactg gagaacggca aacagctcac cgtgaagagg      660

caaggtctgt actacatcta cgctcaggtc accttctgca gcaatcgaga agcaagtagt      720

caggcgccct tcattgccag tttatgtcta aagagcccag gccgctttga gcgtatcctc      780

ctccgcgccg ctaatacgca ctccagcgca aaaccctgtg gccagcagtc aatccacctc      840

ggcggggtgt tcgaactgca acctggcgct tccgtgttcg tgaatgtgac cgatccctca      900

caggtcagcc acggcacggg cttcacctcg ttcgggctgc tgaagctggg gggcggcggc      960

agtggcgggg ggagtaaccc ccagatcgcc gcacacgtga ttagtgaggc gtcctccaag     1020

acaacctccg tgctgcagtg ggccgagaag ggctactaca ccatgagtaa caacctcgta     1080

accctggaga acggaaagca gttaaccgtc aagcgccagg gcctgtacta catctacgcg     1140

caggtcacat tctgctcaaa cagggaggcc tcgtcccagg ccccctttat cgcttccctg     1200

tgcctgaagt ctccgggacg cttcgaacga atcctgctgc gtgcggccaa cacgcactcg     1260

tccgccaaac cgtgtggcca gcagtccata cacctcggcg gcgtgttcga gctgcaacct     1320

ggcgccagcg tgttcgtgaa cgtgacagac ccctcccagg tctcccacgg gacaggtttt     1380

accagtttcg gcctgcttaa gctcggatcc gggggcggcg gttccggcgg ggggggctct     1440

gggggcggcg gctccattga agttatgtat cctcctcctt acctagacaa tgagaagagc     1500

aatggaacca ttatccatgt gaaagggaaa cacctttgtc caagtcccct atttcccgga     1560

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg     1620

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac     1680

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1740

tatgccccac cacgcgactt cgcagcctat cgctcctaa                            1779


<210>  203
<211>  372
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD27 CAR

<400>  203

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg 
    370         


<210>  204
<211>  771
<212>  PRT
<213>  artificial sequence

<220>
<223>  A40C28 - CD27 CAR

<400>  204

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Lys Asp Tyr Tyr Val His Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Glu Asp Gly Asp Ser Lys 
65                  70                  75                  80  


Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Ser Tyr Tyr Val Gly Thr Tyr Gly Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Leu Trp Phe Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Arg Thr Phe Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Arg Thr Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Gln Thr Leu Asn Phe 
    370                 375                 380                 


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met 
385                 390                 395                 400 


Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val Gly 
                405                 410                 415     


Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr Trp 
            420                 425                 430         


Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe Leu 
        435                 440                 445             


Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro Cys 
    450                 455                 460                 


Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His Cys 
465                 470                 475                 480 


Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys Thr 
                485                 490                 495     


Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys Arg 
            500                 505                 510         


Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu Thr 
        515                 520                 525             


Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His Leu 
    530                 535                 540                 


Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met Gln 
545                 550                 555                 560 


Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr His 
                565                 570                 575     


Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile Leu 
            580                 585                 590         


Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala Leu 
        595                 600                 605             


Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro 
    610                 615                 620                 


Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu 
625                 630                 635                 640 


Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala 
                645                 650                 655     


Cys Ser Pro Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            660                 665                 670         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        675                 680                 685             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    690                 695                 700                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
705                 710                 715                 720 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                725                 730                 735     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            740                 745                 750         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        755                 760                 765             


Pro Pro Arg 
    770     


<210>  205
<211>  486
<212>  PRT
<213>  artificial sequence

<220>
<223>  Anti-BCMA CAR (BCMA31)

<400>  205

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala 
            20                  25                  30          


Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser 
        35                  40                  45              


Ser Asp Val Gly Thr Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Gln Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
                85                  90                  95      


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Ser Ser Tyr Gly Gly Ser Asn Asn Leu Val Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ala Asn Ile Lys Pro Asp Gly Ser Asp Lys Tyr Tyr Val 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Asp Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Ala Thr Thr Tyr Gly Ser Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  206
<211>  885
<212>  PRT
<213>  artificial sequence

<220>
<223>  A40C.28-BCMA31.BBZ

<400>  206

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Lys Asp Tyr Tyr Val His Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Glu Asp Gly Asp Ser Lys 
65                  70                  75                  80  


Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Ser Tyr Tyr Val Gly Thr Tyr Gly Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Leu Trp Phe Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Arg Thr Phe Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Arg Thr Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Gln Thr Leu Asn Phe 
    370                 375                 380                 


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met 
385                 390                 395                 400 


Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
                405                 410                 415     


Phe Leu Leu Ile Pro Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser 
            420                 425                 430         


Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser 
        435                 440                 445             


Asp Val Gly Thr Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Gln Arg Pro Ser Gly 
465                 470                 475                 480 


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu 
                485                 490                 495     


Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser 
            500                 505                 510         


Ser Tyr Gly Gly Ser Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Val 
        515                 520                 525             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    530                 535                 540                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro 
545                 550                 555                 560 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                565                 570                 575     


Ser Tyr Trp Met Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
            580                 585                 590         


Trp Val Ala Asn Ile Lys Pro Asp Gly Ser Asp Lys Tyr Tyr Val Asp 
        595                 600                 605             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
    610                 615                 620                 


Leu Asp Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr 
625                 630                 635                 640 


Tyr Cys Ala Arg Gly Ala Thr Thr Tyr Gly Ser Trp Gly Gln Gly Thr 
                645                 650                 655     


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            660                 665                 670         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        675                 680                 685             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    690                 695                 700                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
705                 710                 715                 720 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                725                 730                 735     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            740                 745                 750         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        755                 760                 765             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    770                 775                 780                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
785                 790                 795                 800 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                805                 810                 815     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            820                 825                 830         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        835                 840                 845             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    850                 855                 860                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
865                 870                 875                 880 


Ala Leu Pro Pro Arg 
                885 


<210>  207
<211>  885
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA31.BBZ-A40C.28

<400>  207

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala 
            20                  25                  30          


Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser 
        35                  40                  45              


Ser Asp Val Gly Thr Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Gln Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
                85                  90                  95      


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Ser Ser Tyr Gly Gly Ser Asn Asn Leu Val Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ala Asn Ile Lys Pro Asp Gly Ser Asp Lys Tyr Tyr Val 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Asp Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Ala Thr Thr Tyr Gly Ser Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Val Lys Gln Thr Leu Asn Phe Asp Leu Leu 
                485                 490                 495     


Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Ala Leu Pro 
            500                 505                 510         


Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg 
        515                 520                 525             


Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    530                 535                 540                 


Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp 
545                 550                 555                 560 


Tyr Tyr Val His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                565                 570                 575     


Met Gly Arg Ile Asp Pro Glu Asp Gly Asp Ser Lys Tyr Ala Pro Lys 
            580                 585                 590         


Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Val 
        595                 600                 605             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    610                 615                 620                 


Cys Thr Thr Ser Tyr Tyr Val Gly Thr Tyr Gly Tyr Trp Gly Gln Gly 
625                 630                 635                 640 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            660                 665                 670         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
        675                 680                 685             


Ser Ser Val Ser Tyr Met Leu Trp Phe Gln Gln Lys Pro Gly Lys Ala 
    690                 695                 700                 


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
705                 710                 715                 720 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                725                 730                 735     


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg 
            740                 745                 750         


Thr Phe Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        755                 760                 765             


Arg Thr Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    770                 775                 780                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
785                 790                 795                 800 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                805                 810                 815     


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            820                 825                 830         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        835                 840                 845             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    850                 855                 860                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
865                 870                 875                 880 


Ala Ala Tyr Arg Ser 
                885 


<210>  208
<211>  485
<212>  PRT
<213>  artificial sequence

<220>
<223>  Anti-mesothelin CAR (M12)

<400>  208

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ile Arg Leu Thr Gln Ser Pro Ser Leu Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Gly Gly Gly Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Gly Ala Ser Lys Leu Gln Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu 
            100                 105                 110         


Asn Ser Tyr Pro Val Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Tyr 
                165                 170                 175     


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
            180                 185                 190         


Ile Ile Asn Pro Ser Ser Gly Ser Thr Thr Tyr Thr Gln Lys Phe Gln 
        195                 200                 205             


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Ile 
    210                 215                 220                 


Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Thr Leu Arg Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  209
<211>  486
<212>  PRT
<213>  artificial sequence

<220>
<223>  Anti-mesothelin CAR (M32)

<400>  209

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Val Thr Cys Gln Ala Ser Glu 
        35                  40                  45              


Asp Ile Asn Asn Ser Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Gln Leu Leu Ile Tyr Asp Ala Ser Asp Leu Glu Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Arg Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ile Gly Tyr Tyr 
                165                 170                 175     


Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
            180                 185                 190         


Ile Ile Asn Pro Ser Gly Gly Arg Thr Ser Met Ala Gln Lys Phe Gln 
        195                 200                 205             


Gly Arg Val Ser Met Thr Thr Asp Thr Ser Thr Gly Thr Val Tyr Leu 
    210                 215                 220                 


Asp Leu Gly Arg Leu Gly Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Ala Asp Asn Trp Asn Ala Gly Ser Met Asp Val Trp Gly Asn Gly 
                245                 250                 255     


Thr Thr Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  210
<211>  884
<212>  PRT
<213>  artificial sequence

<220>
<223>  Anti-mesothelin CAR+LACO (A40C28+M12)

<400>  210

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Lys Asp Tyr Tyr Val His Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Glu Asp Gly Asp Ser Lys 
65                  70                  75                  80  


Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Ser Tyr Tyr Val Gly Thr Tyr Gly Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Leu Trp Phe Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Arg Thr Phe Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Arg Thr Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Gln Thr Leu Asn Phe 
    370                 375                 380                 


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met 
385                 390                 395                 400 


Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
                405                 410                 415     


Ala Ala Arg Pro Ala Ile Arg Leu Thr Gln Ser Pro Ser Leu Leu Ser 
            420                 425                 430         


Ala Ser Val Gly Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Gly 
        435                 440                 445             


Gly Gly Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    450                 455                 460                 


Lys Leu Leu Ile Tyr Gly Ala Ser Lys Leu Gln Ser Gly Val Pro Ser 
465                 470                 475                 480 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                485                 490                 495     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn 
            500                 505                 510         


Ser Tyr Pro Val Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    530                 535                 540                 


Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
545                 550                 555                 560 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Tyr Ile 
                565                 570                 575     


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile 
            580                 585                 590         


Ile Asn Pro Ser Ser Gly Ser Thr Thr Tyr Thr Gln Lys Phe Gln Gly 
        595                 600                 605             


Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Ile Glu 
    610                 615                 620                 


Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
625                 630                 635                 640 


Gly Glu Thr Leu Arg Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
                645                 650                 655     


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            660                 665                 670         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        675                 680                 685             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    690                 695                 700                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
705                 710                 715                 720 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                725                 730                 735     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            740                 745                 750         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        755                 760                 765             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    770                 775                 780                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
785                 790                 795                 800 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                805                 810                 815     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            820                 825                 830         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        835                 840                 845             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    850                 855                 860                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
865                 870                 875                 880 


Leu Pro Pro Arg 
                


<210>  211
<211>  519
<212>  PRT
<213>  artificial sequence

<220>
<223>  1412-4D11 (Anti-CD28/anti-CD40 bispecific Ab)

<400>  211

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu Gly 
    130                 135                 140                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met Asp 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            260                 265                 270         


Pro Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser 
        275                 280                 285             


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser 
    290                 295                 300                 


Pro Gly Tyr Tyr Gly Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Ser Ile Tyr Lys Ser Gly Ser Thr Tyr His Asn Pro 
                325                 330                 335     


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
            340                 345                 350         


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Thr Arg Pro Val Val Arg Tyr Phe Gly Trp Phe Asp Pro Trp 
    370                 375                 380                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr 
                405                 410                 415     


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
            420                 425                 430         


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
    450                 455                 460                 


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
465                 470                 475                 480 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
                485                 490                 495     


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Thr Phe Gly Gln Gly Thr 
            500                 505                 510         


Lys Val Glu Ile Lys Arg Thr 
        515                 


<210>  212
<211>  491
<212>  PRT
<213>  artificial sequence

<220>
<223>  Anti-CD123 CAR (C5)

<400>  212

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln Pro His Ser Val Ser 
            20                  25                  30          


Glu Ser Pro Gly Lys Thr Val Thr Leu Ser Cys Thr Arg Ser Ser Gly 
        35                  40                  45              


Ser Ile Ala Gly Ser Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Phe Gln Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Asp Lys Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Asn Asn Gln Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Glu Val His Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly 
                165                 170                 175     


Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ser Gly Ile Asn Trp Asn Gly Gly Arg Thr Gly Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
    210                 215                 220                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Ala Arg Gly Ser Gly Ser Tyr Phe Gly Tyr Met Asp 
                245                 250                 255     


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  213
<211>  495
<212>  PRT
<213>  artificial sequence

<220>
<223>  Anti-CD123 CAR (C7)

<400>  213

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Lys Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Gly Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            180                 185                 190         


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
        195                 200                 205             


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Asp Pro Tyr Asp Asp Tyr Gly Gly Asn Ser Arg Asp Glu Glu 
                245                 250                 255     


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  214
<211>  495
<212>  PRT
<213>  artificial sequence

<220>
<223>  Anti-CD123 CAR (C11)

<400>  214

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Val Val Thr Gln Pro Pro Ser Ala Ser 
            20                  25                  30          


Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Ser Asn Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
                85                  90                  95      


Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
            100                 105                 110         


Trp Asp Asp Ser Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly 
                165                 170                 175     


Asp Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr 
        195                 200                 205             


Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
    210                 215                 220                 


Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Asp Ile Gly Tyr Tyr Gly Ser Gly Ser Tyr 
                245                 250                 255     


Ser Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  215
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker


<220>
<221>  repeat
<222>  (1)..(5)
<223>  (GGGGS)n, n=1, 2, 3, 4, or 5

<400>  215

Gly Gly Gly Gly Ser 
1               5   


<210>  216
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  (EAAAK)n, n=1,2,3, 4,or 5

<400>  216

Glu Ala Ala Ala Lys 
1               5   


<210>  217
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(2)
<223>  (PA)nP, n=1,2,3,4,or 5

<400>  217

Pro Ala Pro 
1           


<210>  218
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  218

Gly Gly Gly Gly Ser 
1               5   


<210>  219
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  219

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  220
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  P2A

<400>  220

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro Met 
            20  


<210>  221
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  T2A

<400>  221

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  222
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2A

<400>  222

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  223
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2A

<400>  223

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  224
<211>  522
<212>  PRT
<213>  artificial sequence

<220>
<223>  4D5-6.CD3 (HER2 BiTE)

<400>  224

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
                165                 170                 175     


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Val Ala Met Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
            260                 265                 270         


Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
        275                 280                 285             


Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
    290                 295                 300                 


Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
305                 310                 315                 320 


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
                325                 330                 335     


Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            340                 345                 350         


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
        355                 360                 365             


Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Ser Gly Gly Val Asp Asp Ala Ala Ile Gln Leu Thr Gln 
                405                 410                 415     


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
            420                 425                 430         


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
        435                 440                 445             


Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
    450                 455                 460                 


Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
465                 470                 475                 480 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
                485                 490                 495     


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            500                 505                 510         


Leu Glu Leu Lys His His His His His His 
        515                 520         


<210>  225
<211>  1569
<212>  DNA
<213>  Artificial sequence

<220>
<223>  4D5-6.CD3 (HER2 BiTE)

<400>  225
atggacttcc aggttcagat cttttcgttc ctgctgatca gcgcctctgt tatcatgtcg       60

cgcggcgaca tccagatgac ccagtcccct tcctccctct ctgcctctgt gggagaccgc      120

gttaccatca catgccgagc ttcccaggac gtgaacacag ccgtggcctg gtaccagcag      180

aagcccggga aggcacccaa actcctcatc tactccgcct ccttcctata cagtggcgtg      240

ccttcccgat tctccggctc caggagtggc acggacttta cgctcaccat tagtagcctg      300

cagcccgaag acttcgcgac ctactattgt cagcaacact acacgacgcc accaactttc      360

ggccagggta ccaaggtcga gattaagcga accggcagta ccagtgggtc tggcaagccc      420

ggcagcggcg agggatccga ggtccagctg gtcgagtccg gcgggggcct ggtgcagccg      480

ggcggctcgc tgaggttatc ttgcgccgcc agtggcttca acatcaagga tacttacatc      540

cactgggtga ggcaggctcc gggcaagggc ctggaatggg tggctaggat ctaccctact      600

aacgggtaca cacgctacgc agattcggtg aaaggccgct tcactatctc cgccgacacc      660

tcgaagaaca ctgcttacct gcagatgaac tccctcaggg ccgaagatac tgcagtctac      720

tactgctccc gctggggtgg ggacggcttc gtcgccatgg acgtgtgggg tcagggcact      780

ctagttacag tgtcatccgg aggtggtgga tccgatatca aactgcagca gtcaggggct      840

gaactggcaa gacctggggc ctcagtgaag atgtcctgca agacttctgg ctacaccttt      900

actaggtaca cgatgcactg ggtaaaacag aggcctggac agggtctgga atggattgga      960

tacattaatc ctagccgtgg ttatactaat tacaatcaga agttcaagga caaggccaca     1020

ttgactacag acaaatcctc cagcacagcc tacatgcaac tgagcagcct gacatctgag     1080

gactctgcgg tctatttctg tgcaagatat tatgatgatc attactgcct tgactactgg     1140

ggccaaggca ccactctcac agtctcctca gtcgaaggtg gaagtggagg ttctggtgga     1200

agtggaggtt cgggtggagt cgacgacgcc gccattcagc tgacccagtc tccagcaatc     1260

atgtctgcat ctccagggga gaaggtcacc atgacctgca gagccagttc aagtgtaagt     1320

tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat ttatgacaca     1380

tccaaagtgg cttctggagt cccttatcgc ttcagtggca gtgggtctgg gacctcatac     1440

tctctcacaa tcagcagcat ggaggctgaa gatgctgcca cttattactg ccaacagtgg     1500

agtagtaacc cgctcacgtt cggtgctggg accaagctgg agctgaaaca tcatcaccat     1560

catcattaa                                                             1569


