                         б

<110>  㽭ѧ

<120>  صø2ƱǾƾ֬βҩеӦ

<160>  4

<170>  SIPOSequenceListing 1.0

<210>  2
<211>  1608
<212>  DNA/RNA
<213>  С󺬻صø2(Mice-FMO2)

<400>  2
atggcaaaga aggttgtggt gattggagca ggggtcagtg gcctaatctc tctgaagtgc        60
tgcgtggacg agggtctgga gcccacctgc ttcgaaagga ctgaagatat agggggactg       120
tggagattca aagaaaacgt ggaagatggc cgcgctagca tctaccgctc tgtcattacc       180
aacactagca aagaaatgtc ctgtttcagt gacttcccga tgccggagga cttccccaac       240
ttcctgcaca actctaaact cctggaatat tttaggatct ttgccaagaa atttgatctc       300
ctaaaatata ttcagtttca gaccactgtc attagtgtga aaaaacgccc ggacttcgca       360
tcttctgggc aatgggaagt ttatactcag agcaacggaa aggagcaacg cactgtcttt       420
gacgctgtta tggtttgcag cggccatcac atccagcctc acctgccact caagtcattc       480
ccaggtattg agaggttccg aggccagtat ttccatagcc gcgaatacaa gcacccagtg       540
gggtttgagg ggaaacgcat cctggtggtt ggaataggaa actcagctgc agatattgcc       600
tctgaactga gtaagacggc cgcgcaggtg tttgtcagca ccagacatgg atcctgggtc       660
atgagtcgaa tctctgaaga tggctaccct tgggacatgg tgttccacac tagatttagc       720
tccatgctcc gaaatgtcct gccccgcacg gtcgtcaagt ggatgatgga acaacagatg       780
aatcgatggt tcaaccatga aaattatggt ctggtgcctc agaacaaata ccttatgaaa       840
gaacctgtgc taaacgacga cctccccagc cgcctgctgt acggagccat caaagtaaaa       900
acacgggtga aggagctcac ggagacagct gtggtcttcg aggatggcac ggtggaggaa       960
gacgtggata tcattgtctt tgccacgggg tatacgttct ctttttcttt cctggaagac      1020
tcacttgtta aagtggagga taatagggtt tccctgtaca aagccatgtt tccccctcac      1080
ctggagaagc caacccttgc gtgcataggt ctcatccagc ctctaggctc catcttccca      1140
accgtagagc ttcaggcgcg ctgggcgaca agagttttca aaggcttgtg tagcttgcct      1200
tcggagacga ctatgatggc agacattgtt gaaagaaatg aaaaaagagt taacctgttt      1260
gggaaaagcc agagtcagat actgcagacc aactacgttg actacctgga tgaactcgcc      1320
ttggagatag gtgcaaagcc agatttcgtc tctctctttt tcaaagaccc taaactggct      1380
gtgaaactct acttcggacc ctgtaattcc taccagtacc gcctggttgg acctgggcag      1440
tgggaaggag ccaggaacgc catcctcacc cagaagcaga ggatcctgaa acccttaaag      1500
acccggactc tccagtcctc tgatagtgcc ccagtgtctt tcctgctcaa gatcctgggg      1560
ctgctcgctg ttgttctggc cttctttttc caacttcagg ggttttaa                   1608

<210>  1
<211>  535
<212>  PRT
<213>  С󺬻صø2(Mice-FMO2)

<400>  1
Met Ala Lys Lys Val Val Val Ile Gly Ala Gly Val Ser Gly Leu Ile 
1               5                   10                  15      
Ser Leu Lys Cys Cys Val Asp Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          
Arg Thr Glu Asp Ile Gly Gly Leu Trp Arg Phe Lys Glu Asn Val Glu 
        35                  40                  45              
Asp Gly Arg Ala Ser Ile Tyr Arg Ser Val Ile Thr Asn Thr Ser Lys 
    50                  55                  60                  
Glu Met Ser Cys Phe Ser Asp Phe Pro Met Pro Glu Asp Phe Pro Asn 
65                  70                  75                  80  
Phe Leu His Asn Ser Lys Leu Leu Glu Tyr Phe Arg Ile Phe Ala Lys 
                85                  90                  95      
Lys Phe Asp Leu Leu Lys Tyr Ile Gln Phe Gln Thr Thr Val Ile Ser 
            100                 105                 110         
Val Lys Lys Arg Pro Asp Phe Ala Ser Ser Gly Gln Trp Glu Val Tyr 
        115                 120                 125             
Thr Gln Ser Asn Gly Lys Glu Gln Arg Thr Val Phe Asp Ala Val Met 
    130                 135                 140                 
Val Cys Ser Gly His His Ile Gln Pro His Leu Pro Leu Lys Ser Phe 
145                 150                 155                 160 
Pro Gly Ile Glu Arg Phe Arg Gly Gln Tyr Phe His Ser Arg Glu Tyr 
                165                 170                 175     
Lys His Pro Val Gly Phe Glu Gly Lys Arg Ile Leu Val Val Gly Ile 
            180                 185                 190         
Gly Asn Ser Ala Ala Asp Ile Ala Ser Glu Leu Ser Lys Thr Ala Ala 
        195                 200                 205             
Gln Val Phe Val Ser Thr Arg His Gly Ser Trp Val Met Ser Arg Ile 
    210                 215                 220                 
Ser Glu Asp Gly Tyr Pro Trp Asp Met Val Phe His Thr Arg Phe Ser 
225                 230                 235                 240 
Ser Met Leu Arg Asn Val Leu Pro Arg Thr Val Val Lys Trp Met Met 
                245                 250                 255     
Glu Gln Gln Met Asn Arg Trp Phe Asn His Glu Asn Tyr Gly Leu Val 
            260                 265                 270         
Pro Gln Asn Lys Tyr Leu Met Lys Glu Pro Val Leu Asn Asp Asp Leu 
        275                 280                 285             
Pro Ser Arg Leu Leu Tyr Gly Ala Ile Lys Val Lys Thr Arg Val Lys 
    290                 295                 300                 
Glu Leu Thr Glu Thr Ala Val Val Phe Glu Asp Gly Thr Val Glu Glu 
305                 310                 315                 320 
Asp Val Asp Ile Ile Val Phe Ala Thr Gly Tyr Thr Phe Ser Phe Ser 
                325                 330                 335     
Phe Leu Glu Asp Ser Leu Val Lys Val Glu Asp Asn Arg Val Ser Leu 
            340                 345                 350         
Tyr Lys Ala Met Phe Pro Pro His Leu Glu Lys Pro Thr Leu Ala Cys 
        355                 360                 365             
Ile Gly Leu Ile Gln Pro Leu Gly Ser Ile Phe Pro Thr Val Glu Leu 
    370                 375                 380                 
Gln Ala Arg Trp Ala Thr Arg Val Phe Lys Gly Leu Cys Ser Leu Pro 
385                 390                 395                 400 
Ser Glu Thr Thr Met Met Ala Asp Ile Val Glu Arg Asn Glu Lys Arg 
                405                 410                 415     
Val Asn Leu Phe Gly Lys Ser Gln Ser Gln Ile Leu Gln Thr Asn Tyr 
            420                 425                 430         
Val Asp Tyr Leu Asp Glu Leu Ala Leu Glu Ile Gly Ala Lys Pro Asp 
        435                 440                 445             
Phe Val Ser Leu Phe Phe Lys Asp Pro Lys Leu Ala Val Lys Leu Tyr 
    450                 455                 460                 
Phe Gly Pro Cys Asn Ser Tyr Gln Tyr Arg Leu Val Gly Pro Gly Gln 
465                 470                 475                 480 
Trp Glu Gly Ala Arg Asn Ala Ile Leu Thr Gln Lys Gln Arg Ile Leu 
                485                 490                 495     
Lys Pro Leu Lys Thr Arg Thr Leu Gln Ser Ser Asp Ser Ala Pro Val 
            500                 505                 510         
Ser Phe Leu Leu Lys Ile Leu Gly Leu Leu Ala Val Val Leu Ala Phe 
        515                 520                 525             
Phe Phe Gln Leu Gln Gly Phe 
    530                 535 

<210>  3
<211>  1608
<212>  DNA/RNA
<213>  ˺صø2(Human-FMO2)

<400>  3
atggcaaaga aggtagctgt gattggagct ggggtcagtg gcctaatttc tctgaagtgc        60
tgtgtggatg agggacttga gcccacttgc tttgagagaa ctgaagatat tggaggagtg       120
tggaggttca aagagaatgt ggaagatggc cgagcaagta tctatcaatc tgtcgttacc       180
aacaccagca aagaaatgtc ctgtttcagt gactttccaa tgcctgaaga ttttccaaac       240
ttcctgcata attctaaact tctggaatat ttcaggattt ttgctaaaaa atttgatctg       300
ctaaaatata ttcagttcca gacaactgtc cttagtgtga gaaaatgtcc agatttctca       360
tcctctggcc aatggaaggt tgtcactcag agcaacggca aggagcagag tgctgtcttt       420
gacgcagtta tggtttgcag tggccaccac attctacctc atatcccact gaagtcattt       480
ccaggtatgg agaggttcaa aggccaatat ttccatagcc gccaatacaa gcatccagat       540
ggatttgagg gaaaacgcat cctggtgatt ggaatgggaa actcaggctc agatattgct       600
gttgagctga gtaagaatgc tgctcaggtt tttatcagca ccaggcatgg cacctgggtc       660
atgagccgta tctctgaaga tggctatcct tgggactcag tgttccacac ccggtttcgt       720
tctatgctcc gcaatgtact gccacgaaca gctgtaaaat ggatgataga acaacagatg       780
aatcggtggt tcaaccatga aaattatggc cttgagcctc aaaacaaata cattatgaag       840
gaacctgtac taaatgatga tgtcccaagt cgtctactct gtggagccat caaggtgaaa       900
tctacagtga aagagctcac agaaacttct gccatctttg aggatggaac agtggaggag       960
aacattgatg tcatcatttt tgcaacagga tatagtttct cttttccctt ccttgaagat      1020
tcactcgtta aagtagagaa taatatggtc tcactgtata aatacatatt ccccgctcac      1080
ctggacaagt caaccctcgc gtgcattggt ctcatccagc ccctaggttc cattttccca      1140
actgctgaac ttcaagctcg ttgggtgaca agagttttca aaggcttgtg tagcctgccc      1200
tcagagagaa ctatgatgat ggacattatc aaaaggaatg aaaaaagaat tgacctgttt      1260
ggagaaagcc agagccagac gttgcagacc aattatgttg actacttgga cgagctcgcc      1320
ttagagatag gtgcgaagcc agatttctgc tctctcttgt tcaaagatcc taaactggct      1380
gtgagactct atttcggacc ctgcaactcc tatcagtatc gcctggttgg gcctgggcaa      1440
tgggaaggag ccagaaatgc catcttcacc cagaaacaaa gaatactgaa gccactcaag      1500
actcgggccc tgaaggattc atctaatttc tcagtttctt ttctgttgaa aatcctgggc      1560
cttcttgctg ttgttgtggc ctttttttgc caacttcaat ggtcctag                   1608

<210>  4
<211>  535
<212>  PRT
<213>  ˺صø2(Human-FMO2)

<400>  4
Met Ala Lys Lys Val Ala Val Ile Gly Ala Gly Val Ser Gly Leu Ile 
1               5                   10                  15      
Ser Leu Lys Cys Cys Val Asp Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          
Arg Thr Glu Asp Ile Gly Gly Val Trp Arg Phe Lys Glu Asn Val Glu 
        35                  40                  45              
Asp Gly Arg Ala Ser Ile Tyr Gln Ser Val Val Thr Asn Thr Ser Lys 
    50                  55                  60                  
Glu Met Ser Cys Phe Ser Asp Phe Pro Met Pro Glu Asp Phe Pro Asn 
65                  70                  75                  80  
Phe Leu His Asn Ser Lys Leu Leu Glu Tyr Phe Arg Ile Phe Ala Lys 
                85                  90                  95      
Lys Phe Asp Leu Leu Lys Tyr Ile Gln Phe Gln Thr Thr Val Leu Ser 
            100                 105                 110         
Val Arg Lys Cys Pro Asp Phe Ser Ser Ser Gly Gln Trp Lys Val Val 
        115                 120                 125             
Thr Gln Ser Asn Gly Lys Glu Gln Ser Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 
Val Cys Ser Gly His His Ile Leu Pro His Ile Pro Leu Lys Ser Phe 
145                 150                 155                 160 
Pro Gly Met Glu Arg Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr 
                165                 170                 175     
Lys His Pro Asp Gly Phe Glu Gly Lys Arg Ile Leu Val Ile Gly Met 
            180                 185                 190         
Gly Asn Ser Gly Ser Asp Ile Ala Val Glu Leu Ser Lys Asn Ala Ala 
        195                 200                 205             
Gln Val Phe Ile Ser Thr Arg His Gly Thr Trp Val Met Ser Arg Ile 
    210                 215                 220                 
Ser Glu Asp Gly Tyr Pro Trp Asp Ser Val Phe His Thr Arg Phe Arg 
225                 230                 235                 240 
Ser Met Leu Arg Asn Val Leu Pro Arg Thr Ala Val Lys Trp Met Ile 
                245                 250                 255     
Glu Gln Gln Met Asn Arg Trp Phe Asn His Glu Asn Tyr Gly Leu Glu 
            260                 265                 270         
Pro Gln Asn Lys Tyr Ile Met Lys Glu Pro Val Leu Asn Asp Asp Val 
        275                 280                 285             
Pro Ser Arg Leu Leu Cys Gly Ala Ile Lys Val Lys Ser Thr Val Lys 
    290                 295                 300                 
Glu Leu Thr Glu Thr Ser Ala Ile Phe Glu Asp Gly Thr Val Glu Glu 
305                 310                 315                 320 
Asn Ile Asp Val Ile Ile Phe Ala Thr Gly Tyr Ser Phe Ser Phe Pro 
                325                 330                 335     
Phe Leu Glu Asp Ser Leu Val Lys Val Glu Asn Asn Met Val Ser Leu 
            340                 345                 350         
Tyr Lys Tyr Ile Phe Pro Ala His Leu Asp Lys Ser Thr Leu Ala Cys 
        355                 360                 365             
Ile Gly Leu Ile Gln Pro Leu Gly Ser Ile Phe Pro Thr Ala Glu Leu 
    370                 375                 380                 
Gln Ala Arg Trp Val Thr Arg Val Phe Lys Gly Leu Cys Ser Leu Pro 
385                 390                 395                 400 
Ser Glu Arg Thr Met Met Met Asp Ile Ile Lys Arg Asn Glu Lys Arg 
                405                 410                 415     
Ile Asp Leu Phe Gly Glu Ser Gln Ser Gln Thr Leu Gln Thr Asn Tyr 
            420                 425                 430         
Val Asp Tyr Leu Asp Glu Leu Ala Leu Glu Ile Gly Ala Lys Pro Asp 
        435                 440                 445             
Phe Cys Ser Leu Leu Phe Lys Asp Pro Lys Leu Ala Val Arg Leu Tyr 
    450                 455                 460                 
Phe Gly Pro Cys Asn Ser Tyr Gln Tyr Arg Leu Val Gly Pro Gly Gln 
465                 470                 475                 480 
Trp Glu Gly Ala Arg Asn Ala Ile Phe Thr Gln Lys Gln Arg Ile Leu 
                485                 490                 495     
Lys Pro Leu Lys Thr Arg Ala Leu Lys Asp Ser Ser Asn Phe Ser Val 
            500                 505                 510         
Ser Phe Leu Leu Lys Ile Leu Gly Leu Leu Ala Val Val Val Ala Phe 
        515                 520                 525             
Phe Cys Gln Leu Gln Trp Ser 
    530                 535 

