                         SEQUENCE LISTING

<110>  Lu, Zheng-Rong
 
<120>  PLASMID VECTORS AND NANOPARTICLES FOR TREATING OCULAR
       DISORDERS

<130>  CWR-029769WO ORD

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  9993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttagcctg      180

gtgctgtgtc agccccgggc tcccaggggc ttcccagtgg tccccaggaa ccctcgacag      240

ggccagggcg tctctctcgt ccagcaaggg cagggacggg ccacaggcaa gggcaccggt      300

atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg      360

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      420

tggttaagga atgccaaccc gctctacagc catcatgaat gccatttccc caacaaggcg      480

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      540

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      600

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      660

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      720

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      780

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      840

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      900

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      960

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata     1020

gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc     1080

ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg     1140

tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc     1200

aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct     1260

gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat     1320

gaagacaata actataaggc ctttctgggg attgactcca caaggaagga tcctatctat     1380

tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat     1440

cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac     1500

actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa     1560

ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac     1620

ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta     1680

aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac     1740

ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg     1800

gacatattta acatcactga tcgcaccctc cgcctggtca atcaatacct ggagtgcttg     1860

gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct     1920

ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc     1980

agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa     2040

accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat     2100

ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca     2160

aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc     2220

tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg     2280

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg     2340

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg     2400

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg     2460

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     2520

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     2580

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     2640

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     2700

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     2760

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     2820

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     2880

tttccaggag actatggaac cccacttcct tggtactttc ttctacaaga gtcgtattgg     2940

cttggcggtg aagggtgttc aaccagagaa gaaagagccc tggaaaagac cgagccccta     3000

acagaggaaa cggaggatcc agagcaccca gaaggaatac acgactcctt ctttgaacgt     3060

gagcatccag ggtgggttcc tggggtatgc gtgaagaatc tggtaaagat ttttgagccc     3120

tgtggccggc cagctgtgga ccgtctgaac atcaccttct acgagaacca gatcaccgca     3180

ttcctgggcc acaatggagc tgggaaaacc accaccttgt ccatcctgac gggtctgttg     3240

ccaccaacct ctgggactgt gctcgttggg ggaagggaca ttgaaaccag cctggatgca     3300

gtccggcaga gccttggcat gtgtccacag cacaacatcc tgttccacca cctcacggtg     3360

gctgagcaca tgctgttcta tgcccagctg aaaggaaagt cccaggagga ggcccagctg     3420

gagatggaag ccatgttgga ggacacaggc ctccaccaca agcggaatga agaggctcag     3480

gacctatcag gtggcatgca gagaaagctg tcggttgcca ttgcctttgt gggagatgcc     3540

aaggtggtga ttctggacga acccacctct ggggtggacc cttactcgag acgctcaatc     3600

tgggatctgc tcctgaagta tcgctcaggc agaaccatca tcatgtccac tcaccacatg     3660

gacgaggccg acctccttgg ggaccgcatt gccatcattg cccagggaag gctctactgc     3720

tcaggcaccc cactcttcct gaagaactgc tttggcacag gcttgtactt aaccttggtg     3780

cgcaagatga aaaacatcca gagccaaagg aaaggcagtg aggggacctg cagctgctcg     3840

tctaagggtt tctccaccac gtgtccagcc cacgtcgatg acctaactcc agaacaagtc     3900

ctggatgggg atgtaaatga gctgatggat gtagttctcc accatgttcc agaggcaaag     3960

ctggtggagt gcattggtca agaacttatc ttccttcttc caaataagaa cttcaagcac     4020

agagcatatg ccagcctttt cagagagctg gaggagacgc tggctgacct tggtctcagc     4080

agttttggaa tttctgacac tcccctggaa gagatttttc tgaaggtcac ggaggattct     4140

gattcaggac ctctgtttgc gggtggcgct cagcagaaaa gagaaaacgt caacccccga     4200

cacccctgct tgggtcccag agagaaggct ggacagacac cccaggactc caatgtctgc     4260

tccccagggg cgccggctgc tcacccagag ggccagcctc ccccagagcc agagtgccca     4320

ggcccgcagc tcaacacggg gacacagctg gtcctccagc atgtgcaggc gctgctggtc     4380

aagagattcc aacacaccat ccgcagccac aaggacttcc tggcgcagat cgtgctcccg     4440

gctacctttg tgtttttggc tctgatgctt tctattgtta tccctccttt tggcgaatac     4500

cccgctttga cccttcaccc ctggatatat gggcagcagt acaccttctt cagcatggat     4560

gaaccaggca gtgagcagtt cacggtactt gcagacgtcc tcctgaataa gccaggcttt     4620

ggcaaccgct gcctgaagga agggtggctt ccggagtacc cctgtggcaa ctcaacaccc     4680

tggaagactc cttctgtgtc cccaaacatc acccagctgt tccagaagca gaaatggaca     4740

caggtcaacc cttcaccatc ctgcaggtgc agcaccaggg agaagctcac catgctgcca     4800

gagtgccccg agggtgccgg gggcctcccg cccccccaga gaacacagcg cagcacggaa     4860

attctacaag acctgacgga caggaacatc tccgacttct tggtaaaaac gtatcctgct     4920

cttataagaa gcagcttaaa gagcaaattc tgggtcaatg aacagaggta tggaggaatt     4980

tccattggag gaaagctccc agtcgtcccc atcacggggg aagcacttgt tgggttttta     5040

agcgaccttg gccggatcat gaatgtgagc gggggcccta tcactagaga ggcctctaaa     5100

gaaatacctg atttccttaa acatctagaa actgaagaca acattaaggt gtggtttaat     5160

aacaaaggct ggcatgccct ggtcagcttt ctcaatgtgg cccacaacgc catcttacgg     5220

gccagcctgc ctaaggacag gagccccgag gagtatggaa tcaccgtcat tagccaaccc     5280

ctgaacctga ccaaggagca gctctcagag attacagtgc tgaccacttc agtggatgct     5340

gtggttgcca tctgcgtgat tttctccatg tccttcgtcc cagccagctt tgtcctttat     5400

ttgatccagg agcgggtgaa caaatccaag cacctccagt ttatcagtgg agtgagcccc     5460

accacctact gggtaaccaa cttcctctgg gacatcatga attattccgt gagtgctggg     5520

ctggtggtgg gcatcttcat cgggtttcag aagaaagcct acacttctcc agaaaacctt     5580

cctgcccttg tggcactgct cctgctgtat ggatgggcgg tcattcccat gatgtaccca     5640

gcatccttcc tgtttgatgt ccccagcaca gcctatgtgg ctttatcttg tgctaatctg     5700

ttcatcggca tcaacagcag tgctattacc ttcatcttgg aattatttga gaataaccgg     5760

acgctgctca ggttcaacgc cgtgctgagg aagctgctca ttgtcttccc ccacttctgc     5820

ctgggccggg gcctcattga ccttgcactg agccaggctg tgacagatgt ctatgcccgg     5880

tttggtgagg agcactctgc aaatccgttc cactgggacc tgattgggaa gaacctgttt     5940

gccatggtgg tggaaggggt ggtgtacttc ctcctgaccc tgctggtcca gcgccacttc     6000

ttcctctccc aatggattgc cgagcccact aaggagccca ttgttgatga agatgatgat     6060

gtggctgaag aaagacaaag aattattact ggtggaaata aaactgacat cttaaggcta     6120

catgaactaa ccaagattta tccaggcacc tccagcccag cagtggacag gctgtgtgtc     6180

ggagttcgcc ctggagagtg ctttggcctc ctgggagtga atggtgccgg caaaacaacc     6240

acattcaaga tgctcactgg ggacaccaca gtgacctcag gggatgccac cgtagcaggc     6300

aagagtattt taaccaatat ttctgaagtc catcaaaata tgggctactg tcctcagttt     6360

gatgcaatcg atgagctgct cacaggacga gaacatcttt acctttatgc ccggcttcga     6420

ggtgtaccag cagaagaaat cgaaaaggtt gcaaactgga gtattaagag cctgggcctg     6480

actgtctacg ccgactgcct ggctggcacg tacagtgggg gcaacaagcg gaaactctcc     6540

acagccatcg cactcattgg ctgcccaccg ctggtgctgc tggatgagcc caccacaggg     6600

atggaccccc aggcacgccg catgctgtgg aacgtcatcg tgagcatcat cagagaaggg     6660

agggctgtgg tcctcacatc ccacagcatg gaagaatgtg aggcactgtg tacccggctg     6720

gccatcatgg taaagggcgc ctttcgatgt atgggcacca ttcagcatct caagtccaaa     6780

tttggagatg gctatatcgt cacaatgaag atcaaatccc cgaaggacga cctgcttcct     6840

gacctgaacc ctgtggagca gttcttccag gggaacttcc caggcagtgt gcagagggag     6900

aggcactaca acatgctcca gttccaggtc tcctcctcct ccctggcgag gatcttccag     6960

ctcctcctct cccacaagga cagcctgctc atcgaggagt actcagtcac acagaccaca     7020

ctggaccagg tgtttgtaaa ttttgctaaa cagcagactg aaagtcatga cctccctctg     7080

caccctcgag ctgctggagc cagtcgacaa gcccaggact gagcggccgc acatttgctt     7140

ctgacacaac tgtgttcact agcaacctca aacagacacc atggtgcatc tgactcctga     7200

ggagaagtct gccgttactg ccctgtgggg caaggtgaac gtggatgaag ttggtggtga     7260

ggccctgggc aggctgctgg tggtctaccc ttggacccag aggttctttg agtcctttgg     7320

ggatctgtcc actcctgatg ctgttatggg caaccctaag gtgaaggctc atggcaagaa     7380

agtgctcggt gcctttagtg atggcctggc tcacctggac aacctcaagg gcacctttgc     7440

cacactgagt gagctgcact gtgacaagct gcacgtggat cctgagaact tcaggctcct     7500

gggcaacgtg ctggtctgtg tgctggccca tcactttggc aaagaattca ccccaccagt     7560

gcaggctgcc tatcagaaag tggtggctgg tgtggctaat gccctggccc acaagtatca     7620

ctaagctcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc ctaagtccaa     7680

ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc taataaaaaa     7740

catttatttt cattgcacta gtattcgaat tcagcaaggt cgccacgcat tcgaattcag     7800

caaggtcgcc acgcacaaga tcaatattaa caatcagtca tctctcttta gcaataaaaa     7860

ggtgaaaaat tacattttaa aaatgacacc atagacgatg tatgaaaata atctacttgg     7920

aaataaatct aggcaaagaa gtgcaagact gttacccaga aaacttacaa attgtaaatg     7980

agaggttagt gaagatttaa atgaatgaag atctaaataa acttataaat tgtgagagaa     8040

attaatgaat gtctaagtta atgcagaaac ggagagacat actatattca tgaactaaaa     8100

gacttaatat tgtgaaggta tactttcttt tcacataaat ttgtagtcaa tatgttcacc     8160

ccaaaaaagc tgtttgttaa cttgtcaacc tcatttcaaa atgtatatag aaagcccaaa     8220

gacaataaca aaaatattct tgtagaacaa aatgggaaag aatgttccac taaatatcaa     8280

gatttagagc aaagcatgag atgtgtgggg atagacagtg aggctgataa aatagagtag     8340

agctcagaaa cagacccatt gatatatgta agtgacctat gaaaaaaata tggcatttta     8400

caatgggaaa atgatgatct ttttcttttt tagaaaaaca gggaaatata tttatatgta     8460

aaaaataaaa gggaacccat atgtcatacc atacacacaa aaaaattcca gtgaattata     8520

agtctaaatg gagaaggcaa aactttaaat cttttagaaa ataatataga agcatgccat     8580

catgacttca gtgtagagaa aaatttctta tgactcaaag tcctaaccac aaagaaaaga     8640

ttgttaatta gattgcatga atattaagac ttatttttaa aattaaaaaa ccattaagaa     8700

aagtcaggcc atagaatgac agaaaatatt tgcaacaccc cagtaaagag aattgtaata     8760

tgcagattat aaaaagaagt cttacaaatc agtaaaaaat aaaactagac aaaaatttga     8820

acagatgaaa gagaaactct aaataatcat tacacatgag aaactcaatc tcagaaatca     8880

gagaactatc attgcatata cactaaatta gagaaatatt aaaaggctaa gtaacatctg     8940

tggcaatatt gatggtatat aaccttgata tgatgtgatg agaacagtac tttaccccat     9000

gggcttcctc cccaaaccct taccccagta taaatcatga caaatatact ttaaaaacca     9060

ttaccctata tctaaccagt actcctcaaa actgtcaagg tcatcaaaaa taagaaaagt     9120

ctgaggaact gtcaaaacta agaggaaccc aaggagacat gagaattata tgtaatgtgg     9180

cattctgaat gagatcccag aacagaaaaa gaacagtagc taaaaaacta atgaaatata     9240

aataaagttt gaactttagt tttttttaaa aaagagtagc attaacacgg caaagtcatt     9300

ttcatatttt tcttgaacat taagtacaag tctataatta aaatttttta aatgtagtct     9360

ggaacattgc cagaaacaga agtacagcag ctatctgtgc tgtcgcctaa ctatccatag     9420

ctgattggtc taaaatgaga tacatcaacg ctcctccatg ttttttgttt tctttttaaa     9480

tgaaaaactt tattttttaa gaggagtttc aggttcatag caaaattgag aggaaggtac     9540

attcaagctg aggaagtttt cctctattcc tagtttactg agagattgca tcatgaatgg     9600

gtgttaaatt ttgtcaaatg ctttttctgt gtctatcaat atgaccatgt gattttcttc     9660

tttaacctgt tgatgggaca aattacgtta attgattttc aaacgttgaa ccacccttac     9720

atatctggaa taaattctac ttggttgtgg tgtatatttt ttgatacatt cttggattct     9780

ttttgctaat attttgttga aaatgtttgt atctttgttc atgagagata ttggtctgtt     9840

gttttctttt cttgtaatgt cattttctag ttccggtatt aaggtaatgc tggcctagtt     9900

gaatgattta ggaagtattc cctctgcttc tgtcttctga aagagattgt agaaagttga     9960

tacaattttt ttttctttaa atatcttgat aga                                  9993


