                         SEQUENCE LISTING

<110>  CERo Therapeutics, Inc.
 
<120>  CHIMERIC TIM RECEPTORS AND USES THEREOF

<130>  200265.414WO

<150>  63/066,085
<151>  2020-08-14

<150>  63/226,643
<151>  2021-07-28

<160>  158   

<170>  PatentIn version 3.5

<210>  1
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Leu 
                325                 330                 335     


Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu 
            340                 345                 350         


Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly 
        355                 360                 365             


Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
    370                 375             


<210>  2
<211>  314
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  2

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln 
305                 310                 


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified IgG4 hinge

<400>  3

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  4
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  4

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  5
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated human CD3z ITAM-containing activating domain

<400>  5

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  6
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  6

Leu Leu Met Ile Ile Ala Pro Ser Leu Gly Phe Val Leu Phe Ala Leu 
1               5                   10                  15      


Phe Val Ala Phe Leu 
            20      


<210>  7
<211>  27
<212>  PRT
<213>  Homo Sapiens

<400>  7

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  8
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  8

Ile Tyr Ala Gly Val Cys Ile Ser Val Leu Val Leu Leu Ala Leu Leu 
1               5                   10                  15      


Gly Val Ile Ile Ala 
            20      


<210>  9
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  9

Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210>  10
<211>  22
<212>  PRT
<213>  Homo Sapiens

<400>  10

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  11
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  11

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser 
            20                  


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A self-cleaving peptide

<400>  12

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A self-cleaving peptide

<400>  13

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A self-cleaving peptide

<400>  14

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  15
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A self-cleaving peptide

<400>  15

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  16
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  16

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His 
        275                 280                 285 


<210>  17
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  17

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80  


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95      


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110         


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys 
        115                 120                 125             


Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140                 


Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175     


Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
            180                 185                 190         


<210>  18
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  18

Met Ala Ser Arg Gly Ala Thr Arg Pro Asn Gly Pro Asn Thr Gly Asn 
1               5                   10                  15      


Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val Gly 
            20                  25                  30          


Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu Phe 
        35                  40                  45              


Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys Leu 
    50                  55                  60                  


Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln Glu 
65                  70                  75                  80  


Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala Ala 
                85                  90                  95      


Ile Val Val Tyr Asp Ile Thr Asn Glu Glu Ser Phe Ala Arg Ala Lys 
            100                 105                 110         


Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val Ile 
        115                 120                 125             


Ala Leu Ser Gly Asn Lys Ala Asp Leu Ala Asn Lys Arg Ala Val Asp 
    130                 135                 140                 


Phe Gln Glu Ala Gln Ser Tyr Ala Asp Asp Asn Ser Leu Leu Phe Met 
145                 150                 155                 160 


Glu Thr Ser Ala Lys Thr Ser Met Asn Val Asn Glu Ile Phe Met Ala 
                165                 170                 175     


Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Pro Gly Ala Asn 
            180                 185                 190         


Ser Ala Arg Gly Arg Gly Val Asp Leu Thr Glu Pro Thr Gln Pro Thr 
        195                 200                 205             


Arg Asn Gln Cys Cys Ser Asn 
    210                 215 


<210>  19
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  19

Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys 
            20                  25                  30          


Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys 
        35                  40                  45              


Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly 
65                  70                  75                  80  


Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe 
                85                  90                  95      


Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Ile Gln Ala Ser Pro 
            100                 105                 110         


Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Ile Asp 
        115                 120                 125             


Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr 
    130                 135                 140                 


Ser Lys Asn Asn Ile Pro Tyr Phe Glu Thr Ser Ala Lys Glu Ala Ile 
145                 150                 155                 160 


Asn Val Glu Gln Ala Phe Gln Thr Ile Ala Arg Asn Ala Leu Lys Gln 
                165                 170                 175     


Glu Thr Glu Val Glu Leu Tyr Asn Glu Phe Pro Glu Pro Ile Lys Leu 
            180                 185                 190         


Asp Lys Asn Asp Arg Ala Lys Ala Ser Ala Glu Ser Cys Ser Cys 
        195                 200                 205         


<210>  20
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  20

Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Cys 
        35                  40                  45              


Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe 
    50                  55                  60                  


Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu 
65                  70                  75                  80  


Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu 
                85                  90                  95      


Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Glu Asp Val Pro Met Ile 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys 
        115                 120                 125             


Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Cys Asn Cys Ala Phe Leu 
    130                 135                 140                 


Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp 
145                 150                 155                 160 


Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Glu Lys Lys Lys Pro 
                165                 170                 175     


Lys Lys Lys Ser Cys Leu Leu Leu 
            180                 


<210>  21
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  21

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val 
            180                 185                 190         


Leu 
    


<210>  22
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  22

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu Leu 
            180                 185                 190     


<210>  23
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  23

Ile Leu Ile Ile Ala Cys Cys Val Gly Phe Val Leu Met Val Leu Leu 
1               5                   10                  15      


Phe Leu Ala Phe Leu 
            20      


<210>  24
<211>  279
<212>  PRT
<213>  Mus musculus


<220>
<221>  SIGNAL
<222>  (1)..(22)

<400>  24

Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu 
            20                  25                  30          


Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser 
        35                  40                  45              


Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys 
    50                  55                  60                  


Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys 
65                  70                  75                  80  


Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg 
        115                 120                 125             


Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr 
    130                 135                 140                 


Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu 
145                 150                 155                 160 


Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro 
                165                 170                 175     


Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro 
            180                 185                 190         


Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala 
        195                 200                 205             


Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg 
    210                 215                 220                 


Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly 
225                 230                 235                 240 


Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys 
                245                 250                 255     


Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His 
            260                 265                 270         


Gln Ile Asn Ser Arg Gln Thr 
        275                 


<210>  25
<211>  22
<212>  PRT
<213>  Mus musculus

<400>  25

Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Ala 
            20          


<210>  26
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD28 costimulatory signaling domain with L186G/L187G 
       substitutions - positions reference to full length protein

<400>  26

Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  27
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  27

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  28
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A self-cleaving peptide variant

<400>  28

Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro 
            20              


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A self-cleaving peptide variant

<400>  29

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro Arg 
            


<210>  30
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A self-cleaving peptide variant

<400>  30

Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro Arg 
            20                  


<210>  31
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A self-cleaving peptide variant

<400>  31

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  32
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge region

<400>  32

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  33
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a transmembrane domain

<400>  33

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  34
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  34

Glu Thr Val Val Thr Glu Val Leu Gly His Arg Val Thr Leu Pro Cys 
1               5                   10                  15      


Leu Tyr Ser Ser Trp Ser His Asn Ser Asn Ser Met Cys Trp Gly Lys 
            20                  25                  30          


Asp Gln Cys Pro Tyr Ser Gly Cys Lys Glu Ala Leu Ile Arg Thr Asp 
        35                  40                  45              


Gly Met Arg Val Thr Ser Arg Lys Ser Ala Lys Tyr Arg Leu Gln Gly 
    50                  55                  60                  


Thr Ile Pro Arg Gly Asp Val Ser Leu Thr Ile Leu Asn Pro Ser Glu 
65                  70                  75                  80  


Ser Asp Ser Gly Val Tyr Cys Cys Arg Ile Glu Val Pro Gly Trp Phe 
                85                  90                  95      


Asn Asp Val Lys Ile Asn Val Arg Leu Asn Leu Gln Arg Ala Ser 
            100                 105                 110     


<210>  35
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  35

Thr Thr Thr His Arg Thr Ala Thr Thr Thr Thr Arg Arg Thr Thr Thr 
1               5                   10                  15      


Thr Ser Pro Thr Thr Thr Arg Gln Met Thr Thr Thr Pro Ala Ala Leu 
            20                  25                  30          


Pro Thr Thr Val Val Thr Thr Pro Asp Leu Thr Thr Gly Thr Pro Leu 
        35                  40                  45              


Gln Met Thr Thr Ile Ala Val Phe Thr Thr Ala Asn Thr Cys Leu Ser 
    50                  55                  60                  


Leu Thr Pro Ser Thr Leu Pro Glu Glu Ala Thr Gly Leu Leu Thr Pro 
65                  70                  75                  80  


Glu Pro Ser Lys Glu Gly Pro Ile Leu Thr Ala Glu Ser Glu Thr Val 
                85                  90                  95      


Leu Pro Ser Asp Ser Trp Ser Ser Val Glu Ser Thr Ser Ala Asp Thr 
            100                 105                 110         


Val Leu Leu Thr Ser Lys Glu Ser Lys Val Trp Asp Leu Pro Ser Thr 
        115                 120                 125             


Ser His Val Ser Met Trp Lys Thr Ser Asp Ser Val Ser Ser Pro Gln 
    130                 135                 140                 


Pro Gly Ala Ser Asp Thr Ala Val Pro Glu Gln Asn Lys Thr Thr Lys 
145                 150                 155                 160 


Thr Gly Gln Met Asp Gly Ile Pro Met Ser Met Lys Asn Glu Met Pro 
                165                 170                 175     


Ile Ser Gln 
            


<210>  36
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  36

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210>  37
<211>  295
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<400>  37

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly 
    290                 295 


<210>  38
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  38

Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val Thr Leu Pro Cys 
1               5                   10                  15      


His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn Arg Gly Ser Cys 
            20                  25                  30          


Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr Asn Gly Thr His 
        35                  40                  45              


Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu Gly Asp Leu Ser 
    50                  55                  60                  


Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala Val Ser Asp Ser 
65                  70                  75                  80  


Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp Phe Asn Asp Met 
                85                  90                  95      


Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
            100                 105             


<210>  39
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  39

Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
1               5                   10                  15      


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
            20                  25                  30          


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
        35                  40                  45              


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
    50                  55                  60                  


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
65                  70                  75                  80  


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
                85                  90                  95      


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
            100                 105                 110         


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
        115                 120                 125             


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
    130                 135                 140                 


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
145                 150                 155                 160 


Thr Ala Asn Thr Thr Lys Gly 
                165         


<210>  40
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  40

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly 
            20  


<210>  41
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified Tim1 IgV domain

<400>  41

Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val Thr Leu Pro Cys 
1               5                   10                  15      


His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn Arg Gly Ser Cys 
            20                  25                  30          


Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr Asn Gly Thr His 
        35                  40                  45              


Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu Gly Asp Leu Ser 
    50                  55                  60                  


Arg Gly Asp Val Ser Leu Thr Ile Glu Asn Thr Ala Val Ser Asp Ser 
65                  70                  75                  80  


Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp Phe Asn Asp Met 
                85                  90                  95      


Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
            100                 105             


<210>  42
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  42

Glu Thr Val Val Thr Glu Val Leu Gly His Arg Val Thr Leu Pro Cys 
1               5                   10                  15      


Leu Tyr Ser Ser Trp Ser His Asn Ser Asn Ser Met Cys Trp Gly Lys 
            20                  25                  30          


Asp Gln Cys Pro Tyr Ser Gly Cys Lys Glu Ala Leu Ile Arg Thr Asp 
        35                  40                  45              


Gly Met Arg Val Thr Ser Arg Lys Ser Ala Lys Tyr Arg Leu Gln Gly 
    50                  55                  60                  


Thr Ile Pro Arg Gly Asp Val Ser Leu Thr Ile Leu Asn Pro Ser Glu 
65                  70                  75                  80  


Ser Asp Ser Gly Val Tyr Cys Cys Arg Ile Glu Val Pro Gly Trp Phe 
                85                  90                  95      


Asn Asp Val Lys Ile Asn Val Arg Leu Asn Leu Gln Arg Ala Ser Thr 
            100                 105                 110         


Thr Thr His Arg Thr Ala Thr Thr Thr Thr Arg Arg Thr Thr Thr Thr 
        115                 120                 125             


Ser Pro Thr Thr Thr Arg Gln Met Thr Thr Thr Pro Ala Ala Leu Pro 
    130                 135                 140                 


Thr Thr Val Val Thr Thr Pro Asp Leu Thr Thr Gly Thr Pro Leu Gln 
145                 150                 155                 160 


Met Thr Thr Ile Ala Val Phe Thr Thr Ala Asn Thr Cys Leu Ser Leu 
                165                 170                 175     


Thr Pro Ser Thr Leu Pro Glu Glu Ala Thr Gly Leu Leu Thr Pro Glu 
            180                 185                 190         


Pro Ser Lys Glu Gly Pro Ile Leu Thr Ala Glu Ser Glu Thr Val Leu 
        195                 200                 205             


Pro Ser Asp Ser Trp Ser Ser Val Glu Ser Thr Ser Ala Asp Thr Val 
    210                 215                 220                 


Leu Leu Thr Ser Lys Glu Ser Lys Val Trp Asp Leu Pro Ser Thr Ser 
225                 230                 235                 240 


His Val Ser Met Trp Lys Thr Ser Asp Ser Val Ser Ser Pro Gln Pro 
                245                 250                 255     


Gly Ala Ser Asp Thr Ala Val Pro Glu Gln Asn Lys Thr Thr Lys Thr 
            260                 265                 270         


Gly Gln Met Asp Gly Ile Pro Met Ser Met Lys Asn Glu Met Pro Ile 
        275                 280                 285             


Ser Gln 
    290 


<210>  43
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  43

Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val Thr Leu Pro Cys 
1               5                   10                  15      


His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn Arg Gly Ser Cys 
            20                  25                  30          


Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr Asn Gly Thr His 
        35                  40                  45              


Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu Gly Asp Leu Ser 
    50                  55                  60                  


Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala Val Ser Asp Ser 
65                  70                  75                  80  


Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp Phe Asn Asp Met 
                85                  90                  95      


Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys Val Thr Thr Thr 
            100                 105                 110         


Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val Arg Thr Ser Thr 
        115                 120                 125             


Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr Val Pro Thr Thr 
    130                 135                 140                 


Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr Thr Val Leu Thr 
145                 150                 155                 160 


Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr Thr Thr Ser Ile 
                165                 170                 175     


Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val Ser Thr Phe Val 
            180                 185                 190         


Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro Val Ala Thr Ser 
        195                 200                 205             


Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr Thr Leu Gln Gly 
    210                 215                 220                 


Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr Ser Tyr Thr Thr 
225                 230                 235                 240 


Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly Leu Trp Asn Asn 
                245                 250                 255     


Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu Thr Ala Asn Thr 
            260                 265                 270         


Thr Lys Gly 
        275 


<210>  44
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  44

Lys Lys Tyr Phe Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe 
1               5                   10                  15      


Ser Ser Leu Gln Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val 
            20                  25                  30          


Gln Ala Glu Asp Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        35                  40                  45              


<210>  45
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  45

Leu Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg 
1               5                   10                  15      


Leu Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His 
            20                  25                  30          


Gly Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
        35                  40              


<210>  46
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRAF6 signaling domain

<400>  46

Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu 
1               5                   10                  15      


Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys 
            20                  25                  30          


Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser 
        35                  40                  45              


Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu 
    50                  55                  60                  


Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala 
65                  70                  75                  80  


Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys 
                85                  90                  95      


Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu 
            100                 105                 110         


Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu 
        115                 120                 125             


Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu 
    130                 135                 140                 


Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met 
145                 150                 155                 160 


Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile 
                165                 170                 175     


His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys 
            180                 185                 190         


Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys 
        195                 200                 205             


Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg 
    210                 215                 220                 


Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile 
225                 230                 235                 240 


Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn 
                245                 250                 255     


His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met 
            260                 265                 270         


Leu Ala 
        


<210>  47
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TLR8 signaling domain

<400>  47

His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu 
1               5                   10                  15      


Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr 
            20                  25                  30          


Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp 
        35                  40                  45              


Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn 
    50                  55                  60                  


Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile 
65                  70                  75                  80  


Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe 
                85                  90                  95      


Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe 
            100                 105                 110         


Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile 
        115                 120                 125             


Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu 
    130                 135                 140                 


Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro 
145                 150                 155                 160 


Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr 
                165                 170                 175     


Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln 
            180                 185                 190         


Tyr 
    


<210>  48
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRAF2 signaling domain

<400>  48

Met Ala Ala Ala Ser Val Thr Pro Pro Gly Ser Leu Glu Leu Leu Gln 
1               5                   10                  15      


Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys Leu Glu Ala Lys Tyr 
            20                  25                  30          


Leu Cys Ser Ala Cys Arg Asn Val Leu Arg Arg Pro Phe Gln Ala Gln 
        35                  40                  45              


Cys Gly His Arg Tyr Cys Ser Phe Cys Leu Ala Ser Ile Leu Ser Ser 
    50                  55                  60                  


Gly Pro Gln Asn Cys Ala Ala Cys Val His Glu Gly Ile Tyr Glu Glu 
65                  70                  75                  80  


Gly Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe Pro Asp Asn Ala Ala 
                85                  90                  95      


Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys Pro Ser Asp Gly Cys 
            100                 105                 110         


Thr Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser Cys His Glu Gly Arg 
        115                 120                 125             


Cys Pro Leu Met Leu Thr Glu Cys Pro Ala Cys Lys Gly Leu Val Arg 
    130                 135                 140                 


Leu Gly Glu Lys Glu Arg His Leu Glu His Glu Cys Pro Glu Arg Ser 
145                 150                 155                 160 


Leu Ser Cys Arg His Cys Arg Ala Pro Cys Cys Gly Ala Asp Val Lys 
                165                 170                 175     


Ala His His Glu Val Cys Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys 
            180                 185                 190         


Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp His Val Lys Thr 
        195                 200                 205             


Cys Gly Lys Cys Arg Val Pro Cys Arg Phe His Ala Ile Gly Cys Leu 
    210                 215                 220                 


Glu Thr Val Glu Gly Glu Lys Gln Gln Glu His Glu Val Gln Trp Leu 
225                 230                 235                 240 


Arg Glu His Leu Ala Met Leu Leu Ser Ser Val Leu Glu Ala Lys Pro 
                245                 250                 255     


Leu Leu Gly Asp Gln Ser His Ala Gly Ser Glu Leu Leu Gln Arg Cys 
            260                 265                 270         


Glu Ser Leu Glu Lys Lys Thr Ala Thr Phe Glu Asn Ile Val Cys Val 
        275                 280                 285             


Leu Asn Arg Glu Val Glu Arg Val Ala Met Thr Ala Glu Ala Cys 
    290                 295                 300             


<210>  49
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin - Tim1TM - Tim1SD - CD3zSD

<400>  49

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp Arg Val Lys Phe 
        355                 360                 365             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
385                 390                 395                 400 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                405                 410                 415     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            420                 425                 430         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        435                 440                 445             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    450                 455                 460                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475     


<210>  50
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin - Tim1TM - Tim4SD - CD3zSD

<400>  50

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Leu Arg Gly Lys 
305                 310                 315                 320 


Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu Asp Tyr Ile 
                325                 330                 335     


Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly Arg Glu Asp 
            340                 345                 350         


Glu Asp Gly Leu Phe Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210>  51
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin - CD28TM - CD28SD

<400>  51

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Phe Trp Val Leu Val Val Val Gly Gly 
    290                 295                 300                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
305                 310                 315                 320 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                325                 330                 335     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            340                 345                 350         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        355                 360             


<210>  52
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin -Tim1TM - TRAF6SD

<400>  52

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Met Ser Leu Leu 
305                 310                 315                 320 


Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu Ser Asp Cys Cys 
                325                 330                 335     


Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys Asp Asp Ser Val 
            340                 345                 350         


Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser Phe Met Glu Glu 
        355                 360                 365             


Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu Glu Ser Lys Tyr 
    370                 375                 380                 


Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala Val Gln Thr Pro 
385                 390                 395                 400 


Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys Ser Ile Arg Asp 
                405                 410                 415     


Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu Leu Glu Asn Gln 
            420                 425                 430         


Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu Ser Leu Met Val 
        435                 440                 445             


Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu Leu Arg His Leu 
    450                 455                 460                 


Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met Asp Cys Pro Gln 
465                 470                 475                 480 


Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile His Ile Leu Lys 
                485                 490                 495     


Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys Ala Ala Ser Met 
            500                 505                 510         


Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys Pro Leu Ala Asn 
        515                 520                 525             


Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg Glu Gln Met Pro 
    530                 535                 540                 


Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile Pro Cys Thr Phe 
545                 550                 555                 560 


Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn His Leu Ala Arg 
                565                 570                 575     


His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met Leu Ala 
            580                 585                 590 


<210>  53
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin -CD28TM - TRAF6SD

<400>  53

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Phe Trp Val Leu Val Val Val Gly Gly 
    290                 295                 300                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
305                 310                 315                 320 


Trp Val Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln 
                325                 330                 335     


Ser Glu Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val 
            340                 345                 350         


Thr Lys Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser 
        355                 360                 365             


Ser Ser Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro 
    370                 375                 380                 


Pro Leu Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg 
385                 390                 395                 400 


Glu Ala Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile 
                405                 410                 415     


Ile Lys Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu 
            420                 425                 430         


Ile Leu Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu 
        435                 440                 445             


Ile Leu Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys 
    450                 455                 460                 


Met Glu Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala 
465                 470                 475                 480 


Leu Met Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile 
                485                 490                 495     


Asn Ile His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp 
            500                 505                 510         


Asn Cys Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln 
        515                 520                 525             


Asn Cys Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu 
    530                 535                 540                 


Ile Arg Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala 
545                 550                 555                 560 


Pro Ile Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln 
                565                 570                 575     


Arg Asn His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met 
            580                 585                 590         


Arg Met Leu Ala 
        595     


<210>  54
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin - Tim1TM - TRAF2SD

<400>  54

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Met Ala Ala Ala 
305                 310                 315                 320 


Ser Val Thr Pro Pro Gly Ser Leu Glu Leu Leu Gln Pro Gly Phe Ser 
                325                 330                 335     


Lys Thr Leu Leu Gly Thr Lys Leu Glu Ala Lys Tyr Leu Cys Ser Ala 
            340                 345                 350         


Cys Arg Asn Val Leu Arg Arg Pro Phe Gln Ala Gln Cys Gly His Arg 
        355                 360                 365             


Tyr Cys Ser Phe Cys Leu Ala Ser Ile Leu Ser Ser Gly Pro Gln Asn 
    370                 375                 380                 


Cys Ala Ala Cys Val His Glu Gly Ile Tyr Glu Glu Gly Ile Ser Ile 
385                 390                 395                 400 


Leu Glu Ser Ser Ser Ala Phe Pro Asp Asn Ala Ala Arg Arg Glu Val 
                405                 410                 415     


Glu Ser Leu Pro Ala Val Cys Pro Ser Asp Gly Cys Thr Trp Lys Gly 
            420                 425                 430         


Thr Leu Lys Glu Tyr Glu Ser Cys His Glu Gly Arg Cys Pro Leu Met 
        435                 440                 445             


Leu Thr Glu Cys Pro Ala Cys Lys Gly Leu Val Arg Leu Gly Glu Lys 
    450                 455                 460                 


Glu Arg His Leu Glu His Glu Cys Pro Glu Arg Ser Leu Ser Cys Arg 
465                 470                 475                 480 


His Cys Arg Ala Pro Cys Cys Gly Ala Asp Val Lys Ala His His Glu 
                485                 490                 495     


Val Cys Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys Gly Lys Lys Lys 
            500                 505                 510         


Ile Pro Arg Glu Lys Phe Gln Asp His Val Lys Thr Cys Gly Lys Cys 
        515                 520                 525             


Arg Val Pro Cys Arg Phe His Ala Ile Gly Cys Leu Glu Thr Val Glu 
    530                 535                 540                 


Gly Glu Lys Gln Gln Glu His Glu Val Gln Trp Leu Arg Glu His Leu 
545                 550                 555                 560 


Ala Met Leu Leu Ser Ser Val Leu Glu Ala Lys Pro Leu Leu Gly Asp 
                565                 570                 575     


Gln Ser His Ala Gly Ser Glu Leu Leu Gln Arg Cys Glu Ser Leu Glu 
            580                 585                 590         


Lys Lys Thr Ala Thr Phe Glu Asn Ile Val Cys Val Leu Asn Arg Glu 
        595                 600                 605             


Val Glu Arg Val Ala Met Thr Ala Glu Ala Cys 
    610                 615                 


<210>  55
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin - CD28TM - TRAF2SD

<400>  55

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Phe Trp Val Leu Val Val Val Gly Gly 
    290                 295                 300                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
305                 310                 315                 320 


Trp Val Met Ala Ala Ala Ser Val Thr Pro Pro Gly Ser Leu Glu Leu 
                325                 330                 335     


Leu Gln Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys Leu Glu Ala 
            340                 345                 350         


Lys Tyr Leu Cys Ser Ala Cys Arg Asn Val Leu Arg Arg Pro Phe Gln 
        355                 360                 365             


Ala Gln Cys Gly His Arg Tyr Cys Ser Phe Cys Leu Ala Ser Ile Leu 
    370                 375                 380                 


Ser Ser Gly Pro Gln Asn Cys Ala Ala Cys Val His Glu Gly Ile Tyr 
385                 390                 395                 400 


Glu Glu Gly Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe Pro Asp Asn 
                405                 410                 415     


Ala Ala Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys Pro Ser Asp 
            420                 425                 430         


Gly Cys Thr Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser Cys His Glu 
        435                 440                 445             


Gly Arg Cys Pro Leu Met Leu Thr Glu Cys Pro Ala Cys Lys Gly Leu 
    450                 455                 460                 


Val Arg Leu Gly Glu Lys Glu Arg His Leu Glu His Glu Cys Pro Glu 
465                 470                 475                 480 


Arg Ser Leu Ser Cys Arg His Cys Arg Ala Pro Cys Cys Gly Ala Asp 
                485                 490                 495     


Val Lys Ala His His Glu Val Cys Pro Lys Phe Pro Leu Thr Cys Asp 
            500                 505                 510         


Gly Cys Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp His Val 
        515                 520                 525             


Lys Thr Cys Gly Lys Cys Arg Val Pro Cys Arg Phe His Ala Ile Gly 
    530                 535                 540                 


Cys Leu Glu Thr Val Glu Gly Glu Lys Gln Gln Glu His Glu Val Gln 
545                 550                 555                 560 


Trp Leu Arg Glu His Leu Ala Met Leu Leu Ser Ser Val Leu Glu Ala 
                565                 570                 575     


Lys Pro Leu Leu Gly Asp Gln Ser His Ala Gly Ser Glu Leu Leu Gln 
            580                 585                 590         


Arg Cys Glu Ser Leu Glu Lys Lys Thr Ala Thr Phe Glu Asn Ile Val 
        595                 600                 605             


Cys Val Leu Asn Arg Glu Val Glu Arg Val Ala Met Thr Ala Glu Ala 
    610                 615                 620                 


Cys 
625 


<210>  56
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin - Tim1TM - TLR8SD - CD3zSD

<400>  56

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala His His Leu Phe 
305                 310                 315                 320 


Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu Ala Lys Val Lys 
                325                 330                 335     


Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp Ala Tyr Ile 
            340                 345                 350         


Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val Ile Asn Glu 
        355                 360                 365             


Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn Val Leu Leu Cys 
    370                 375                 380                 


Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu 
385                 390                 395                 400 


Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys 
                405                 410                 415     


Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr Leu Ala Leu 
            420                 425                 430         


Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu 
        435                 440                 445             


Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu Arg Gln Arg Ile 
    450                 455                 460                 


Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Gly 
465                 470                 475                 480 


Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr Glu Asn Asp Ser 
                485                 490                 495     


Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr Arg Val Lys 
            500                 505                 510         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        515                 520                 525             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    530                 535                 540                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
545                 550                 555                 560 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                565                 570                 575     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            580                 585                 590         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        595                 600                 605             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620     


<210>  57
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin - CD28TM - CD28SD - DAP12SD

<400>  57

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Phe Trp Val Leu Val Val Val Gly Gly 
    290                 295                 300                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
305                 310                 315                 320 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                325                 330                 335     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            340                 345                 350         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Tyr Phe Leu Gly Arg 
        355                 360                 365             


Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln 
    370                 375                 380                 


Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg 
385                 390                 395                 400 


Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
                405                 410                 415 


<210>  58
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim1IgV - Tim1Mucin - Tim1TM - CD28SD - DAP12SD

<400>  58

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg 
        355                 360                 365             


Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu 
    370                 375                 380                 


Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
385                 390                 395                 400 


Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
                405                 


<210>  59
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim4Mucin - Tim4TM - Tim4SD - CD3zSD

<400>  59

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Leu 
                325                 330                 335     


Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu 
            340                 345                 350         


Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly 
        355                 360                 365             


Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  60
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim4Mucin - Tim4TM - Tim1SD - CD3zSD

<400>  60

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Lys 
                325                 330                 335     


Lys Tyr Phe Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser 
            340                 345                 350         


Ser Leu Gln Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln 
        355                 360                 365             


Ala Glu Asp Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  61
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim4Mucin - CD28TM - CD28SD

<400>  61

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375                 380         


<210>  62
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim4Mucin - Tim4TM - TRAF6SD

<400>  62

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Met 
                325                 330                 335     


Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu Ser 
            340                 345                 350         


Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys Asp 
        355                 360                 365             


Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser Phe 
    370                 375                 380                 


Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu Glu 
385                 390                 395                 400 


Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala Val 
                405                 410                 415     


Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys Ser 
            420                 425                 430         


Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu Leu 
        435                 440                 445             


Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu Ser 
    450                 455                 460                 


Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu Leu 
465                 470                 475                 480 


Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met Asp 
                485                 490                 495     


Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile His 
            500                 505                 510         


Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys Ala 
        515                 520                 525             


Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys Pro 
    530                 535                 540                 


Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg Glu 
545                 550                 555                 560 


Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile Pro 
                565                 570                 575     


Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn His 
            580                 585                 590         


Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met Leu 
        595                 600                 605             


Ala 
    


<210>  63
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim4Mucin - CD28TM - TRAF6SD

<400>  63

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly 
            340                 345                 350         


Ser Ser Gln Ser Glu Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys 
        355                 360                 365             


Ser Ala Val Thr Lys Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly 
    370                 375                 380                 


Asn Leu Ser Ser Ser Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu 
385                 390                 395                 400 


Phe Asp Pro Pro Leu Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met 
                405                 410                 415     


Ala Leu Arg Glu Ala Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys 
            420                 425                 430         


Ala Cys Ile Ile Lys Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val 
        435                 440                 445             


Asp Asn Glu Ile Leu Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala 
    450                 455                 460                 


Lys Arg Glu Ile Leu Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys 
465                 470                 475                 480 


Leu His Lys Met Glu Leu Arg His Leu Glu Asp His Gln Ala His Cys 
                485                 490                 495     


Glu Phe Ala Leu Met Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys 
            500                 505                 510         


Phe His Ile Asn Ile His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val 
        515                 520                 525             


Ser Cys Asp Asn Cys Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile 
    530                 535                 540                 


His Asp Gln Asn Cys Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn 
545                 550                 555                 560 


Thr Ile Leu Ile Arg Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys 
                565                 570                 575     


Pro Thr Ala Pro Ile Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu 
            580                 585                 590         


Lys Met Gln Arg Asn His Leu Ala Arg His Leu Gln Glu Asn Thr Gln 
        595                 600                 605             


Ser His Met Arg Met Leu Ala 
    610                 615 


<210>  64
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim4Mucin - Tim4TM - TRAF2SD

<400>  64

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Met 
                325                 330                 335     


Ala Ala Ala Ser Val Thr Pro Pro Gly Ser Leu Glu Leu Leu Gln Pro 
            340                 345                 350         


Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys Leu Glu Ala Lys Tyr Leu 
        355                 360                 365             


Cys Ser Ala Cys Arg Asn Val Leu Arg Arg Pro Phe Gln Ala Gln Cys 
    370                 375                 380                 


Gly His Arg Tyr Cys Ser Phe Cys Leu Ala Ser Ile Leu Ser Ser Gly 
385                 390                 395                 400 


Pro Gln Asn Cys Ala Ala Cys Val His Glu Gly Ile Tyr Glu Glu Gly 
                405                 410                 415     


Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe Pro Asp Asn Ala Ala Arg 
            420                 425                 430         


Arg Glu Val Glu Ser Leu Pro Ala Val Cys Pro Ser Asp Gly Cys Thr 
        435                 440                 445             


Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser Cys His Glu Gly Arg Cys 
    450                 455                 460                 


Pro Leu Met Leu Thr Glu Cys Pro Ala Cys Lys Gly Leu Val Arg Leu 
465                 470                 475                 480 


Gly Glu Lys Glu Arg His Leu Glu His Glu Cys Pro Glu Arg Ser Leu 
                485                 490                 495     


Ser Cys Arg His Cys Arg Ala Pro Cys Cys Gly Ala Asp Val Lys Ala 
            500                 505                 510         


His His Glu Val Cys Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys Gly 
        515                 520                 525             


Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp His Val Lys Thr Cys 
    530                 535                 540                 


Gly Lys Cys Arg Val Pro Cys Arg Phe His Ala Ile Gly Cys Leu Glu 
545                 550                 555                 560 


Thr Val Glu Gly Glu Lys Gln Gln Glu His Glu Val Gln Trp Leu Arg 
                565                 570                 575     


Glu His Leu Ala Met Leu Leu Ser Ser Val Leu Glu Ala Lys Pro Leu 
            580                 585                 590         


Leu Gly Asp Gln Ser His Ala Gly Ser Glu Leu Leu Gln Arg Cys Glu 
        595                 600                 605             


Ser Leu Glu Lys Lys Thr Ala Thr Phe Glu Asn Ile Val Cys Val Leu 
    610                 615                 620                 


Asn Arg Glu Val Glu Arg Val Ala Met Thr Ala Glu Ala Cys 
625                 630                 635             


<210>  65
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim4Mucin - CD28TM - TRAF2SD

<400>  65

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Met Ala Ala Ala Ser Val Thr Pro Pro Gly Ser 
            340                 345                 350         


Leu Glu Leu Leu Gln Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys 
        355                 360                 365             


Leu Glu Ala Lys Tyr Leu Cys Ser Ala Cys Arg Asn Val Leu Arg Arg 
    370                 375                 380                 


Pro Phe Gln Ala Gln Cys Gly His Arg Tyr Cys Ser Phe Cys Leu Ala 
385                 390                 395                 400 


Ser Ile Leu Ser Ser Gly Pro Gln Asn Cys Ala Ala Cys Val His Glu 
                405                 410                 415     


Gly Ile Tyr Glu Glu Gly Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe 
            420                 425                 430         


Pro Asp Asn Ala Ala Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys 
        435                 440                 445             


Pro Ser Asp Gly Cys Thr Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser 
    450                 455                 460                 


Cys His Glu Gly Arg Cys Pro Leu Met Leu Thr Glu Cys Pro Ala Cys 
465                 470                 475                 480 


Lys Gly Leu Val Arg Leu Gly Glu Lys Glu Arg His Leu Glu His Glu 
                485                 490                 495     


Cys Pro Glu Arg Ser Leu Ser Cys Arg His Cys Arg Ala Pro Cys Cys 
            500                 505                 510         


Gly Ala Asp Val Lys Ala His His Glu Val Cys Pro Lys Phe Pro Leu 
        515                 520                 525             


Thr Cys Asp Gly Cys Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln 
    530                 535                 540                 


Asp His Val Lys Thr Cys Gly Lys Cys Arg Val Pro Cys Arg Phe His 
545                 550                 555                 560 


Ala Ile Gly Cys Leu Glu Thr Val Glu Gly Glu Lys Gln Gln Glu His 
                565                 570                 575     


Glu Val Gln Trp Leu Arg Glu His Leu Ala Met Leu Leu Ser Ser Val 
            580                 585                 590         


Leu Glu Ala Lys Pro Leu Leu Gly Asp Gln Ser His Ala Gly Ser Glu 
        595                 600                 605             


Leu Leu Gln Arg Cys Glu Ser Leu Glu Lys Lys Thr Ala Thr Phe Glu 
    610                 615                 620                 


Asn Ile Val Cys Val Leu Asn Arg Glu Val Glu Arg Val Ala Met Thr 
625                 630                 635                 640 


Ala Glu Ala Cys 
                


<210>  66
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim4Mucin - Tim1TM - TLR8SD - CD3zSD

<400>  66

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Ile Tyr Ala Gly Val Cys 
305                 310                 315                 320 


Ile Ser Val Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala His 
                325                 330                 335     


His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu Ala 
            340                 345                 350         


Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp 
        355                 360                 365             


Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val 
    370                 375                 380                 


Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn Val 
385                 390                 395                 400 


Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile 
                405                 410                 415     


Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe Val 
            420                 425                 430         


Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr 
        435                 440                 445             


Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile Phe 
    450                 455                 460                 


Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu Arg 
465                 470                 475                 480 


Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys 
                485                 490                 495     


Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr Glu 
            500                 505                 510         


Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr 
        515                 520                 525             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    530                 535                 540                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
545                 550                 555                 560 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                565                 570                 575     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            580                 585                 590         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        595                 600                 605             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    610                 615                 620                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635                 640 


<210>  67
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim1Mucin - Tim1TM - TLR8SD - CD3zSD

<400>  67

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Val Thr Thr Thr Pro Ile Val Thr Thr 
    130                 135                 140                 


Val Pro Thr Val Thr Thr Val Arg Thr Ser Thr Thr Val Pro Thr Thr 
145                 150                 155                 160 


Thr Thr Val Pro Met Thr Thr Val Pro Thr Thr Thr Val Pro Thr Thr 
                165                 170                 175     


Met Ser Ile Pro Thr Thr Thr Thr Val Leu Thr Thr Met Thr Val Ser 
            180                 185                 190         


Thr Thr Thr Ser Val Pro Thr Thr Thr Ser Ile Pro Thr Thr Thr Ser 
        195                 200                 205             


Val Pro Val Thr Thr Thr Val Ser Thr Phe Val Pro Pro Met Pro Leu 
    210                 215                 220                 


Pro Arg Gln Asn His Glu Pro Val Ala Thr Ser Pro Ser Ser Pro Gln 
225                 230                 235                 240 


Pro Ala Glu Thr His Pro Thr Thr Leu Gln Gly Ala Ile Arg Arg Glu 
                245                 250                 255     


Pro Thr Ser Ser Pro Leu Tyr Ser Tyr Thr Thr Asp Gly Asn Asp Thr 
            260                 265                 270         


Val Thr Glu Ser Ser Asp Gly Leu Trp Asn Asn Asn Gln Thr Gln Leu 
        275                 280                 285             


Phe Leu Glu His Ser Leu Leu Thr Ala Asn Thr Thr Lys Gly Ile Tyr 
    290                 295                 300                 


Ala Gly Val Cys Ile Ser Val Leu Val Leu Leu Ala Leu Leu Gly Val 
305                 310                 315                 320 


Ile Ile Ala His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn 
                325                 330                 335     


Val Cys Leu Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln 
            340                 345                 350         


Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val 
        355                 360                 365             


Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg 
    370                 375                 380                 


Asp Lys Asn Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly 
385                 390                 395                 400 


Leu Ala Ile Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys 
                405                 410                 415     


Thr Val Phe Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys 
            420                 425                 430         


Thr Ala Phe Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp 
        435                 440                 445             


Val Ile Ile Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr 
    450                 455                 460                 


Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro 
465                 470                 475                 480 


Asp Asn Pro Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val 
                485                 490                 495     


Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser 
            500                 505                 510         


Ile Lys Gln Tyr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        515                 520                 525             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    530                 535                 540                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
545                 550                 555                 560 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                565                 570                 575     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            580                 585                 590         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        595                 600                 605             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    610                 615                 620                 


Leu Pro Pro Arg 
625             


<210>  68
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim1Mucin - Tim1TM - CD28SD - DAP12SD

<400>  68

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Val Thr Thr Thr Pro Ile Val Thr Thr 
    130                 135                 140                 


Val Pro Thr Val Thr Thr Val Arg Thr Ser Thr Thr Val Pro Thr Thr 
145                 150                 155                 160 


Thr Thr Val Pro Met Thr Thr Val Pro Thr Thr Thr Val Pro Thr Thr 
                165                 170                 175     


Met Ser Ile Pro Thr Thr Thr Thr Val Leu Thr Thr Met Thr Val Ser 
            180                 185                 190         


Thr Thr Thr Ser Val Pro Thr Thr Thr Ser Ile Pro Thr Thr Thr Ser 
        195                 200                 205             


Val Pro Val Thr Thr Thr Val Ser Thr Phe Val Pro Pro Met Pro Leu 
    210                 215                 220                 


Pro Arg Gln Asn His Glu Pro Val Ala Thr Ser Pro Ser Ser Pro Gln 
225                 230                 235                 240 


Pro Ala Glu Thr His Pro Thr Thr Leu Gln Gly Ala Ile Arg Arg Glu 
                245                 250                 255     


Pro Thr Ser Ser Pro Leu Tyr Ser Tyr Thr Thr Asp Gly Asn Asp Thr 
            260                 265                 270         


Val Thr Glu Ser Ser Asp Gly Leu Trp Asn Asn Asn Gln Thr Gln Leu 
        275                 280                 285             


Phe Leu Glu His Ser Leu Leu Thr Ala Asn Thr Thr Lys Gly Ile Tyr 
    290                 295                 300                 


Ala Gly Val Cys Ile Ser Val Leu Val Leu Leu Ala Leu Leu Gly Val 
305                 310                 315                 320 


Ile Ile Ala Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                325                 330                 335     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            340                 345                 350         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Tyr Phe Leu Gly 
        355                 360                 365             


Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys 
    370                 375                 380                 


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
385                 390                 395                 400 


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
                405                 410                 415     


<210>  69
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Tim - Tim4IgV - Tim1Mucin - CD28TM - CD28SD - DAP12SD

<400>  69

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Val Thr Thr Thr Pro Ile Val Thr Thr 
    130                 135                 140                 


Val Pro Thr Val Thr Thr Val Arg Thr Ser Thr Thr Val Pro Thr Thr 
145                 150                 155                 160 


Thr Thr Val Pro Met Thr Thr Val Pro Thr Thr Thr Val Pro Thr Thr 
                165                 170                 175     


Met Ser Ile Pro Thr Thr Thr Thr Val Leu Thr Thr Met Thr Val Ser 
            180                 185                 190         


Thr Thr Thr Ser Val Pro Thr Thr Thr Ser Ile Pro Thr Thr Thr Ser 
        195                 200                 205             


Val Pro Val Thr Thr Thr Val Ser Thr Phe Val Pro Pro Met Pro Leu 
    210                 215                 220                 


Pro Arg Gln Asn His Glu Pro Val Ala Thr Ser Pro Ser Ser Pro Gln 
225                 230                 235                 240 


Pro Ala Glu Thr His Pro Thr Thr Leu Gln Gly Ala Ile Arg Arg Glu 
                245                 250                 255     


Pro Thr Ser Ser Pro Leu Tyr Ser Tyr Thr Thr Asp Gly Asn Asp Thr 
            260                 265                 270         


Val Thr Glu Ser Ser Asp Gly Leu Trp Asn Asn Asn Gln Thr Gln Leu 
        275                 280                 285             


Phe Leu Glu His Ser Leu Leu Thr Ala Asn Thr Thr Lys Gly Phe Trp 
    290                 295                 300                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
305                 310                 315                 320 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
                325                 330                 335     


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
            340                 345                 350         


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
        355                 360                 365             


Arg Ser Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    370                 375                 380                 


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
385                 390                 395                 400 


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                405                 410                 415     


Gln Arg Pro Tyr Tyr Lys 
            420         


<210>  70
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a hinge region

<400>  70

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-004 HCDR1

<400>  71

Gly Tyr Leu Met Ser 
1               5   


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-004 HCDR2

<400>  72

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-004 HCDR3

<400>  73

Ala Arg Arg Asp Thr Asn Leu Phe Asp Tyr 
1               5                   10  


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-004 LCDR1

<400>  74

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-004 LCDR2

<400>  75

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-004 LCDR3

<400>  76

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-025 HCDR1

<400>  77

Ser Tyr Tyr Met His 
1               5   


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-025 HCDR2

<400>  78

Ile Ile Asn Pro Ser Gly Gly Gly Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-025 HCDR3

<400>  79

Asp Tyr Tyr Val Thr Tyr Asp Ser Trp Phe Asp Ser 
1               5                   10          


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-025 LCDR1

<400>  80

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-025 LCDR2

<400>  81

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-025 LCDR3

<400>  82

Asn Ser Arg Asp Ser Ser Gly Asn His Val Val 
1               5                   10      


<210>  83
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-004 VH

<400>  83

Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
1               5                   10                  15      


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr Leu Met Ser 
            20                  25                  30          


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile 
        35                  40                  45              


Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala 
                85                  90                  95      


Arg Arg Asp Thr Asn Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val 
        


<210>  84
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-004 VL

<400>  84

Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        35                  40                  45              


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
65                  70                  75                  80  


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile 
            100                 


<210>  85
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-025 VH

<400>  85

Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
1               5                   10                  15      


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 
            20                  25                  30          


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile 
        35                  40                  45              


Asn Pro Ser Gly Gly Gly Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg 
    50                  55                  60                  


Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu 
65                  70                  75                  80  


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
                85                  90                  95      


Tyr Tyr Val Thr Tyr Asp Ser Trp Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  86
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-025 VL

<400>  86

Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
1               5                   10                  15      


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
            20                  25                  30          


Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile 
        35                  40                  45              


Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 
    50                  55                  60                  


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
65                  70                  75                  80  


Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val 
        


<210>  87
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-004 scFv

<400>  87

Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly 
            20                  25                  30          


Tyr Leu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Arg Arg Asp Thr Asn Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Leu Glu Gly Thr Gly Gly Ser Gly Gly Thr 
        115                 120                 125             


Gly Ser Gly Thr Gly Thr Ser Glu Leu Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg Ala Ala Ala 
                


<210>  88
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sc02-025 scFv

<400>  88

Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Ile Ile Asn Pro Ser Gly Gly Gly Thr Ser Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Val Thr Tyr Asp Ser Trp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro 
    130                 135                 140                 


Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly 
145                 150                 155                 160 


Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu 
        195                 200                 205             


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn 
    210                 215                 220                 


Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu Gly Ala Ala Ala 
                245             


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  89

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  90

Gly Thr Gly Gly Ser Gly Gly Thr Gly Ser Gly Thr Gly Thr Ser 
1               5                   10                  15  


<210>  91
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge region (short)

<400>  91

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  92
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a hinge region

<400>  92

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  93
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge region

<400>  93

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Lys Pro 
        35              


<210>  94
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a transmembrane region

<400>  94

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  95
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane region

<400>  95

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  96
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wildtype CD3z signaling domain

<400>  96

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  97
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant CD3z signaling domain

<400>  97

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  98
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wildtype CD28 costimulatory signaling domain

<400>  98

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  99
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant CD28 costimulatory signaling domain with L186G/L187G 
       substitutions with positions in reference to full length protein

<400>  99

Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  100
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB costimulatory signaling domain

<400>  100

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  101
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pCTX206 CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-004 
       scFv - IgG4 Hinge - CD28 TM - CD28 ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  101

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Gly Tyr Leu Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Arg Asp Thr Asn Leu Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Leu Glu Gly Thr Gly 
    130                 135                 140                 


Gly Ser Gly Gly Thr Gly Ser Gly Thr Gly Thr Ser Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        275                 280                 285             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    290                 295                 300                 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
305                 310                 315                 320 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
                325                 330                 335     


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
            340                 345                 350         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        355                 360                 365             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    370                 375                 380                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
385                 390                 395                 400 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                405                 410                 415     


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            420                 425                 430         


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        435                 440                 445             


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455             


<210>  102
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pCTX208 CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-025 
       scFv - IgG4 Hinge - CD28 TM - CD28 ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  102

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Val Thr Tyr Asp Ser 
        115                 120                 125             


Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Glu Ser Lys 
            260                 265                 270         


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val 
        275                 280                 285             


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    290                 295                 300                 


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  103
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21)  - sc02-004 scFv - 
       IgG4 Hinge - CD28 TM - 4-1BB ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  103

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Gly Tyr Leu Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Arg Asp Thr Asn Leu Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Leu Glu Gly Thr Gly 
    130                 135                 140                 


Gly Ser Gly Gly Thr Gly Ser Gly Thr Gly Thr Ser Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        275                 280                 285             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    290                 295                 300                 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
305                 310                 315                 320 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
                325                 330                 335     


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
            340                 345                 350         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        355                 360                 365             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    370                 375                 380                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210>  104
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-025 scFv - 
       IgG4 Hinge - CD28 TM - 4-1BB ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  104

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Val Thr Tyr Asp Ser 
        115                 120                 125             


Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Glu Ser Lys 
            260                 265                 270         


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val 
        275                 280                 285             


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    290                 295                 300                 


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
305                 310                 315                 320 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                325                 330                 335     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
385                 390                 395                 400 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                405                 410                 415     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            420                 425                 430         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        435                 440                 445             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460             


<210>  105
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-004 scFv - 
       CD28 Hinge - CD28 TM - CD28 ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  105

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Gly Tyr Leu Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Arg Asp Thr Asn Leu Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Leu Glu Gly Thr Gly 
    130                 135                 140                 


Gly Ser Gly Gly Thr Gly Ser Gly Thr Gly Thr Ser Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro 
            260                 265                 270         


Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys 
        275                 280                 285             


Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
    290                 295                 300                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
305                 310                 315                 320 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                325                 330                 335     


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
            340                 345                 350         


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
        355                 360                 365             


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  106
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-025 scFv - 
       CD28 Hinge - CD28 TM - CD28 ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  106

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Val Thr Tyr Asp Ser 
        115                 120                 125             


Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Ile Glu Val 
            260                 265                 270         


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
        275                 280                 285             


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    290                 295                 300                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
305                 310                 315                 320 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  107
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-004 scFv - 
       CD28 Hinge - CD28 TM - 4-1BB ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  107

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Gly Tyr Leu Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Arg Asp Thr Asn Leu Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Leu Glu Gly Thr Gly 
    130                 135                 140                 


Gly Ser Gly Gly Thr Gly Ser Gly Thr Gly Thr Ser Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro 
            260                 265                 270         


Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys 
        275                 280                 285             


Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
    290                 295                 300                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
305                 310                 315                 320 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  108
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-025 scFv - 
       CD28 Hinge - CD28 TM - 4-1BB ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  108

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Val Thr Tyr Asp Ser 
        115                 120                 125             


Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Ile Glu Val 
            260                 265                 270         


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
        275                 280                 285             


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    290                 295                 300                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
305                 310                 315                 320 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  109
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21)- sc02-004 scFv - 
       IgG4 Hinge - CD8a TM - CD28 ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  109

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Gly Tyr Leu Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Arg Asp Thr Asn Leu Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Leu Glu Gly Thr Gly 
    130                 135                 140                 


Gly Ser Gly Gly Thr Gly Ser Gly Thr Gly Thr Ser Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        275                 280                 285             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
    290                 295                 300                 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
305                 310                 315                 320 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
                325                 330                 335     


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            340                 345                 350         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        355                 360                 365             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    370                 375                 380                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                405                 410                 415     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             


Met Gln Ala Leu Pro Pro Arg 
    450                 455 


<210>  110
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21)- sc02-025 scFv - 
       IgG4 Hinge - CD8a TM - CD28 ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  110

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Val Thr Tyr Asp Ser 
        115                 120                 125             


Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Glu Ser Lys 
            260                 265                 270         


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Tyr Ile Trp Ala Pro Leu 
        275                 280                 285             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    290                 295                 300                 


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
305                 310                 315                 320 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                325                 330                 335     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
            340                 345                 350         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        355                 360                 365             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    370                 375                 380                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210>  111
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-004 scFv - 
       CD8a Hinge - CD8a TM - CD28 ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  111

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Gly Tyr Leu Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Arg Asp Thr Asn Leu Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Leu Glu Gly Thr Gly 
    130                 135                 140                 


Gly Ser Gly Gly Thr Gly Ser Gly Thr Gly Thr Ser Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  112
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-025 scFv - 
       CD8a Hinge - CD8a TM - CD28 ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  112

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Val Thr Tyr Asp Ser 
        115                 120                 125             


Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  113
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21)  - sc02-004 scFv - 
       IgG4 Hinge - CD8a TM - 4-1BB ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  113

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Gly Tyr Leu Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Arg Asp Thr Asn Leu Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Leu Glu Gly Thr Gly 
    130                 135                 140                 


Gly Ser Gly Gly Thr Gly Ser Gly Thr Gly Thr Ser Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        275                 280                 285             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
    290                 295                 300                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
305                 310                 315                 320 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                325                 330                 335     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            340                 345                 350         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        355                 360                 365             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    370                 375                 380                 


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg 
    450                 455     


<210>  114
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-025 scFv - 
       IgG4 Hinge - CD8a TM - 4-1BB ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  114

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Val Thr Tyr Asp Ser 
        115                 120                 125             


Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Glu Ser Lys 
            260                 265                 270         


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Tyr Ile Trp Ala Pro Leu 
        275                 280                 285             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    290                 295                 300                 


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
305                 310                 315                 320 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                325                 330                 335     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 


<210>  115
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-004 scFv- 
       CD8a Hinge - CD8a TM - 4-1BB ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  115

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Gly Tyr Leu Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Arg Asp Thr Asn Leu Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Leu Glu Gly Thr Gly 
    130                 135                 140                 


Gly Ser Gly Gly Thr Gly Ser Gly Thr Gly Thr Ser Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  116
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR: GMSCFR signal peptide (amino acids 1-21) - sc02-025 scFv- 
       CD8a Hinge - CD8a TM - 4-1BB ICD - CD3z


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  116

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Gly Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Val Thr Tyr Asp Ser 
        115                 120                 125             


Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu 
145                 150                 155                 160 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
                165                 170                 175     


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        195                 200                 205             


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  117
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMCSFR_Signal Peptide

<400>  117

Met Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
1               5                   10                  15      


Phe Leu Leu Ile Pro 
            20      


<210>  118
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  118

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser 
            20                  


<210>  119
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  119

Glu Thr Val Val Thr Glu Val Leu Gly His Arg Val Thr Leu Pro Cys 
1               5                   10                  15      


Leu Tyr Ser Ser Trp Ser His Asn Ser Asn Ser Met Cys Trp Gly Lys 
            20                  25                  30          


Asp Gln Cys Pro Tyr Ser Gly Cys Lys Glu Ala Leu Ile Arg Thr Asp 
        35                  40                  45              


Gly Met Arg Val Thr Ser Arg Lys Ser Ala Lys Tyr Arg Leu Gln Gly 
    50                  55                  60                  


Thr Ile Pro Arg Gly Asp Val Ser Leu Thr Ile Leu Asn Pro Ser Glu 
65                  70                  75                  80  


Ser Asp Ser Gly Val Tyr Cys Cys Arg Ile Glu Val Pro Gly Trp Phe 
                85                  90                  95      


Asn Asp Val Lys Ile Asn Val Arg Leu Asn Leu Gln Arg Ala Ser Thr 
            100                 105                 110         


Thr Thr His Arg Thr Ala Thr Thr Thr Thr Arg Arg Thr Thr Thr Thr 
        115                 120                 125             


Ser Pro Thr Thr Thr Arg Gln Met Thr Thr Thr Pro Ala Ala Leu Pro 
    130                 135                 140                 


Thr Thr Val Val Thr Thr Pro Asp Leu Thr Thr Gly Thr Pro Leu Gln 
145                 150                 155                 160 


Met Thr Thr Ile Ala Val Phe Thr Thr Ala Asn Thr Cys Leu Ser Leu 
                165                 170                 175     


Thr Pro Ser Thr Leu Pro Glu Glu Ala Thr Gly Leu Leu Thr Pro Glu 
            180                 185                 190         


Pro Ser Lys Glu Gly Pro Ile Leu Thr Ala Glu Ser Glu Thr Val Leu 
        195                 200                 205             


Pro Ser Asp Ser Trp Ser Ser Val Glu Ser Thr Ser Ala Asp Thr Val 
    210                 215                 220                 


Leu Leu Thr Ser Lys Glu Ser Lys Val Trp Asp Leu Pro Ser Thr Ser 
225                 230                 235                 240 


His Val Ser Met Trp Lys Thr Ser Asp Ser Val Ser Ser Pro Gln Pro 
                245                 250                 255     


Gly Ala Ser Asp Thr Ala Val Pro Glu Gln Asn Lys Thr Thr Lys Thr 
            260                 265                 270         


Gly Gln Met Asp Gly Ile Pro Met Ser Met Lys Asn Glu Met Pro Ile 
        275                 280                 285             


Ser Gln 
    290 


<210>  120
<211>  27
<212>  PRT
<213>  Homo Sapiens

<400>  120

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  121
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  121

Leu Leu Met Ile Ile Ala Pro Ser Leu Gly Phe Val Leu Phe Ala Leu 
1               5                   10                  15      


Phe Val Ala Phe Leu 
            20      


<210>  122
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  122

His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp Leu 
1               5                   10                  15      


Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys Tyr 
            20                  25                  30          


Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu Asn 
        35                  40                  45              


Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu Cys 
    50                  55                  60                  


Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn Ile 
65                  70                  75                  80  


Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser Glu 
                85                  90                  95      


Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser His 
            100                 105                 110         


Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu Leu 
        115                 120                 125             


Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu Arg 
    130                 135                 140                 


Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu Ala 
145                 150                 155                 160 


Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
                165                 170                 175 


<210>  123
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  123

His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu 
1               5                   10                  15      


Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr 
            20                  25                  30          


Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp 
        35                  40                  45              


Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn 
    50                  55                  60                  


Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile 
65                  70                  75                  80  


Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe 
                85                  90                  95      


Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe 
            100                 105                 110         


Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile 
        115                 120                 125             


Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu 
    130                 135                 140                 


Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro 
145                 150                 155                 160 


Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr 
                165                 170                 175     


Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln 
            180                 185                 190         


Tyr 
    


<210>  124
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  124

Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu 
1               5                   10                  15      


Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly 
            20                  25                  30          


Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
        35                  40          


<210>  125
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  125

Met Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg 
1               5                   10                  15      


Leu Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His 
            20                  25                  30          


Gly Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
        35                  40              


<210>  126

<400>  126
000

<210>  127
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-CD28icd-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  127

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  128
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-CD28icd-TLR2ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  128

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser His Arg 
    370                 375                 380                 


Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp Leu Gln Ala 
385                 390                 395                 400 


Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys Tyr Asp Ala 
                405                 410                 415     


Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu Asn Leu Met 
            420                 425                 430         


Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu Cys Leu His 
        435                 440                 445             


Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn Ile Ile Asp 
    450                 455                 460                 


Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser Glu Asn Phe 
465                 470                 475                 480 


Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser His Phe Arg 
                485                 490                 495     


Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu Leu Glu Pro 
            500                 505                 510         


Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu Arg Lys Ile 
        515                 520                 525             


Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu Ala Gln Arg 
    530                 535                 540                 


Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser Arg Val Lys 
545                 550                 555                 560 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                565                 570                 575     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            580                 585                 590         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        595                 600                 605             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    610                 615                 620                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
625                 630                 635                 640 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                645                 650                 655     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 670 


<210>  129
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-CD28icd-CD3zICD-TLR2ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  129

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg His 
                485                 490                 495     


Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp Leu Gln 
            500                 505                 510         


Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys Tyr Asp 
        515                 520                 525             


Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu Asn Leu 
    530                 535                 540                 


Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu Cys Leu 
545                 550                 555                 560 


His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn Ile Ile 
                565                 570                 575     


Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser Glu Asn 
            580                 585                 590         


Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser His Phe 
        595                 600                 605             


Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu Leu Glu 
    610                 615                 620                 


Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu Arg Lys 
625                 630                 635                 640 


Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu Ala Gln 
                645                 650                 655     


Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
            660                 665                 670 


<210>  130
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-CD28icd-TLR8ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  130

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser His His 
    370                 375                 380                 


Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu Ala Lys 
385                 390                 395                 400 


Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp Ala 
                405                 410                 415     


Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val Ile 
            420                 425                 430         


Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn Val Leu 
        435                 440                 445             


Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile Asp 
    450                 455                 460                 


Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe Val Leu 
465                 470                 475                 480 


Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr Leu 
                485                 490                 495     


Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile Phe Ile 
            500                 505                 510         


Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu Arg Gln 
        515                 520                 525             


Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys Ala 
    530                 535                 540                 


Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr Glu Asn 
545                 550                 555                 560 


Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr Arg 
                565                 570                 575     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            580                 585                 590         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        595                 600                 605             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    610                 615                 620                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
625                 630                 635                 640 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                645                 650                 655     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            660                 665                 670         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 685             


<210>  131
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-CD28icd-CD3zICD-TLR8ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  131

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg His 
                485                 490                 495     


His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu Ala 
            500                 505                 510         


Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp 
        515                 520                 525             


Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val 
    530                 535                 540                 


Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn Val 
545                 550                 555                 560 


Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile 
                565                 570                 575     


Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe Val 
            580                 585                 590         


Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr 
        595                 600                 605             


Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile Phe 
    610                 615                 620                 


Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu Arg 
625                 630                 635                 640 


Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys 
                645                 650                 655     


Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr Glu 
            660                 665                 670         


Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr 
        675                 680                 685             


<210>  132
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-TLR2ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  132

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val His Arg Phe His Gly Leu Trp Tyr Met Lys Met 
            340                 345                 350         


Met Trp Ala Trp Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser 
        355                 360                 365             


Arg Asn Ile Cys Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala 
    370                 375                 380                 


Tyr Trp Val Glu Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro 
385                 390                 395                 400 


Pro Phe Lys Leu Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp 
                405                 410                 415     


Ile Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val 
            420                 425                 430         


Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu 
        435                 440                 445             


Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala 
    450                 455                 460                 


Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg 
465                 470                 475                 480 


Phe Cys Lys Leu Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp 
                485                 490                 495     


Pro Met Asp Glu Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala 
            500                 505                 510         


Ala Ile Lys Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        515                 520                 525             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    530                 535                 540                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
545                 550                 555                 560 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                565                 570                 575     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            580                 585                 590         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        595                 600                 605             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    610                 615                 620                 


Ala Leu Pro Pro Arg 
625                 


<210>  133
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-CD3zICD-TLR2ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  133

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            340                 345                 350         


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        355                 360                 365             


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    370                 375                 380                 


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                405                 410                 415     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            420                 425                 430         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        435                 440                 445             


Gln Ala Leu Pro Pro Arg His Arg Phe His Gly Leu Trp Tyr Met Lys 
    450                 455                 460                 


Met Met Trp Ala Trp Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro 
465                 470                 475                 480 


Ser Arg Asn Ile Cys Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp 
                485                 490                 495     


Ala Tyr Trp Val Glu Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn 
            500                 505                 510         


Pro Pro Phe Lys Leu Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys 
        515                 520                 525             


Trp Ile Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr 
    530                 535                 540                 


Val Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr 
545                 550                 555                 560 


Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala 
                565                 570                 575     


Ala Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln 
            580                 585                 590         


Arg Phe Cys Lys Leu Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu 
        595                 600                 605             


Trp Pro Met Asp Glu Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg 
    610                 615                 620                 


Ala Ala Ile Lys Ser 
625                 


<210>  134
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-TLR8ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  134

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val His His Leu Phe Tyr Trp Asp Val Trp Phe Ile 
            340                 345                 350         


Tyr Asn Val Cys Leu Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr 
        355                 360                 365             


Ser Gln Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala 
    370                 375                 380                 


Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu 
385                 390                 395                 400 


Ser Arg Asp Lys Asn Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp 
                405                 410                 415     


Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser 
            420                 425                 430         


Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn 
        435                 440                 445             


Phe Lys Thr Ala Phe Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn 
    450                 455                 460                 


Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser 
465                 470                 475                 480 


Gln Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln 
                485                 490                 495     


Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg 
            500                 505                 510         


Asn Val Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val 
        515                 520                 525             


Asp Ser Ile Lys Gln Tyr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    530                 535                 540                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
545                 550                 555                 560 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                565                 570                 575     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            580                 585                 590         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        595                 600                 605             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    610                 615                 620                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
625                 630                 635                 640 


Met Gln Ala Leu Pro Pro Arg 
                645         


<210>  135
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-CD3zICD-TLR8ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  135

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            340                 345                 350         


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        355                 360                 365             


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    370                 375                 380                 


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                405                 410                 415     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            420                 425                 430         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        435                 440                 445             


Gln Ala Leu Pro Pro Arg His His Leu Phe Tyr Trp Asp Val Trp Phe 
    450                 455                 460                 


Ile Tyr Asn Val Cys Leu Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser 
465                 470                 475                 480 


Thr Ser Gln Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp 
                485                 490                 495     


Ala Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu Glu 
            500                 505                 510         


Glu Ser Arg Asp Lys Asn Val Leu Leu Cys Leu Glu Glu Arg Asp Trp 
        515                 520                 525             


Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln Ser Ile Asn Gln 
    530                 535                 540                 


Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp 
545                 550                 555                 560 


Asn Phe Lys Thr Ala Phe Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu 
                565                 570                 575     


Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro Val Leu Gln His 
            580                 585                 590         


Ser Gln Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu 
        595                 600                 605             


Gln Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu 
    610                 615                 620                 


Arg Asn Val Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr 
625                 630                 635                 640 


Val Asp Ser Ile Lys Gln Tyr 
                645         


<210>  136
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-TRAF6ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  136

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly 
            340                 345                 350         


Ser Ser Gln Ser Glu Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys 
        355                 360                 365             


Ser Ala Val Thr Lys Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly 
    370                 375                 380                 


Asn Leu Ser Ser Ser Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu 
385                 390                 395                 400 


Phe Asp Pro Pro Leu Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met 
                405                 410                 415     


Ala Leu Arg Glu Ala Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys 
            420                 425                 430         


Ala Cys Ile Ile Lys Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val 
        435                 440                 445             


Asp Asn Glu Ile Leu Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala 
    450                 455                 460                 


Lys Arg Glu Ile Leu Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys 
465                 470                 475                 480 


Leu His Lys Met Glu Leu Arg His Leu Glu Asp His Gln Ala His Cys 
                485                 490                 495     


Glu Phe Ala Leu Met Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys 
            500                 505                 510         


Phe His Ile Asn Ile His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val 
        515                 520                 525             


Ser Cys Asp Asn Cys Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile 
    530                 535                 540                 


His Asp Gln Asn Cys Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn 
545                 550                 555                 560 


Thr Ile Leu Ile Arg Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys 
                565                 570                 575     


Pro Thr Ala Pro Ile Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu 
            580                 585                 590         


Lys Met Gln Arg Asn His Leu Ala Arg His Leu Gln Glu Asn Thr Gln 
        595                 600                 605             


Ser His Met Arg Met Leu Ala Arg Val Lys Phe Ser Arg Ser Ala Asp 
    610                 615                 620                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
625                 630                 635                 640 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                645                 650                 655     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            660                 665                 670         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        675                 680                 685             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    690                 695                 700                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
705                 710                 715                 720 


His Met Gln Ala Leu Pro Pro Arg 
                725             


<210>  137
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-CD28tm-CD3zICD-TRAF6ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  137

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            340                 345                 350         


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        355                 360                 365             


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    370                 375                 380                 


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                405                 410                 415     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            420                 425                 430         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        435                 440                 445             


Gln Ala Leu Pro Pro Arg Met Ser Leu Leu Asn Cys Glu Asn Ser Cys 
    450                 455                 460                 


Gly Ser Ser Gln Ser Glu Ser Asp Cys Cys Val Ala Met Ala Ser Ser 
465                 470                 475                 480 


Cys Ser Ala Val Thr Lys Asp Asp Ser Val Gly Gly Thr Ala Ser Thr 
                485                 490                 495     


Gly Asn Leu Ser Ser Ser Phe Met Glu Glu Ile Gln Gly Tyr Asp Val 
            500                 505                 510         


Glu Phe Asp Pro Pro Leu Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu 
        515                 520                 525             


Met Ala Leu Arg Glu Ala Val Gln Thr Pro Cys Gly His Arg Phe Cys 
    530                 535                 540                 


Lys Ala Cys Ile Ile Lys Ser Ile Arg Asp Ala Gly His Lys Cys Pro 
545                 550                 555                 560 


Val Asp Asn Glu Ile Leu Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe 
                565                 570                 575     


Ala Lys Arg Glu Ile Leu Ser Leu Met Val Lys Cys Pro Asn Glu Gly 
            580                 585                 590         


Cys Leu His Lys Met Glu Leu Arg His Leu Glu Asp His Gln Ala His 
        595                 600                 605             


Cys Glu Phe Ala Leu Met Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln 
    610                 615                 620                 


Lys Phe His Ile Asn Ile His Ile Leu Lys Asp Cys Pro Arg Arg Gln 
625                 630                 635                 640 


Val Ser Cys Asp Asn Cys Ala Ala Ser Met Ala Phe Glu Asp Lys Glu 
                645                 650                 655     


Ile His Asp Gln Asn Cys Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys 
            660                 665                 670         


Asn Thr Ile Leu Ile Arg Glu Gln Met Pro Asn His Tyr Asp Leu Asp 
        675                 680                 685             


Cys Pro Thr Ala Pro Ile Pro Cys Thr Phe Ser Thr Phe Gly Cys His 
    690                 695                 700                 


Glu Lys Met Gln Arg Asn His Leu Ala Arg His Leu Gln Glu Asn Thr 
705                 710                 715                 720 


Gln Ser His Met Arg Met Leu Ala 
                725             


<210>  138
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-CD28icd-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  138

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  139
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-CD28icd-TLR2ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  139

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser His Arg Phe His Gly Leu Trp Tyr 
    370                 375                 380                 


Met Lys Met Met Trp Ala Trp Leu Gln Ala Lys Arg Lys Pro Arg Lys 
385                 390                 395                 400 


Ala Pro Ser Arg Asn Ile Cys Tyr Asp Ala Phe Val Ser Tyr Ser Glu 
                405                 410                 415     


Arg Asp Ala Tyr Trp Val Glu Asn Leu Met Val Gln Glu Leu Glu Asn 
            420                 425                 430         


Phe Asn Pro Pro Phe Lys Leu Cys Leu His Lys Arg Asp Phe Ile Pro 
        435                 440                 445             


Gly Lys Trp Ile Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Ser His 
    450                 455                 460                 


Lys Thr Val Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp Cys 
465                 470                 475                 480 


Lys Tyr Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn Asn 
                485                 490                 495     


Asp Ala Ala Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala Ile 
            500                 505                 510         


Pro Gln Arg Phe Cys Lys Leu Arg Lys Ile Met Asn Thr Lys Thr Tyr 
        515                 520                 525             


Leu Glu Trp Pro Met Asp Glu Ala Gln Arg Glu Gly Phe Trp Val Asn 
    530                 535                 540                 


Leu Arg Ala Ala Ile Lys Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
545                 550                 555                 560 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                565                 570                 575     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            580                 585                 590         


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
        595                 600                 605             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    610                 615                 620                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
625                 630                 635                 640 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                645                 650                 655     


His Met Gln Ala Leu Pro Pro Arg 
            660                 


<210>  140
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-CD28icd-CD3zICD-TLR2ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  140

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg His Arg Phe His Gly Leu Trp 
                485                 490                 495     


Tyr Met Lys Met Met Trp Ala Trp Leu Gln Ala Lys Arg Lys Pro Arg 
            500                 505                 510         


Lys Ala Pro Ser Arg Asn Ile Cys Tyr Asp Ala Phe Val Ser Tyr Ser 
        515                 520                 525             


Glu Arg Asp Ala Tyr Trp Val Glu Asn Leu Met Val Gln Glu Leu Glu 
    530                 535                 540                 


Asn Phe Asn Pro Pro Phe Lys Leu Cys Leu His Lys Arg Asp Phe Ile 
545                 550                 555                 560 


Pro Gly Lys Trp Ile Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Ser 
                565                 570                 575     


His Lys Thr Val Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp 
            580                 585                 590         


Cys Lys Tyr Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn 
        595                 600                 605             


Asn Asp Ala Ala Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala 
    610                 615                 620                 


Ile Pro Gln Arg Phe Cys Lys Leu Arg Lys Ile Met Asn Thr Lys Thr 
625                 630                 635                 640 


Tyr Leu Glu Trp Pro Met Asp Glu Ala Gln Arg Glu Gly Phe Trp Val 
                645                 650                 655     


Asn Leu Arg Ala Ala Ile Lys Ser 
            660                 


<210>  141
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-CD28icd-TLR8ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  141

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser His His Leu Phe Tyr Trp Asp Val 
    370                 375                 380                 


Trp Phe Ile Tyr Asn Val Cys Leu Ala Lys Val Lys Gly Tyr Arg Ser 
385                 390                 395                 400 


Leu Ser Thr Ser Gln Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr 
                405                 410                 415     


Lys Asp Ala Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr His 
            420                 425                 430         


Leu Glu Glu Ser Arg Asp Lys Asn Val Leu Leu Cys Leu Glu Glu Arg 
        435                 440                 445             


Asp Trp Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln Ser Ile 
    450                 455                 460                 


Asn Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr Ala Lys 
465                 470                 475                 480 


Ser Trp Asn Phe Lys Thr Ala Phe Tyr Leu Ala Leu Gln Arg Leu Met 
                485                 490                 495     


Asp Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro Val Leu 
            500                 505                 510         


Gln His Ser Gln Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser 
        515                 520                 525             


Ile Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu Phe Trp Gln 
    530                 535                 540                 


Thr Leu Arg Asn Val Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn Asn 
545                 550                 555                 560 


Met Tyr Val Asp Ser Ile Lys Gln Tyr Arg Val Lys Phe Ser Arg Ser 
                565                 570                 575     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            580                 585                 590         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        595                 600                 605             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
    610                 615                 620                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
625                 630                 635                 640 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                645                 650                 655     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            660                 665                 670         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680         


<210>  142
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-CD28icd-CD3zICD-TLR8ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  142

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg His His Leu Phe Tyr Trp Asp 
                485                 490                 495     


Val Trp Phe Ile Tyr Asn Val Cys Leu Ala Lys Val Lys Gly Tyr Arg 
            500                 505                 510         


Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp 
        515                 520                 525             


Thr Lys Asp Ala Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr 
    530                 535                 540                 


His Leu Glu Glu Ser Arg Asp Lys Asn Val Leu Leu Cys Leu Glu Glu 
545                 550                 555                 560 


Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln Ser 
                565                 570                 575     


Ile Asn Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr Ala 
            580                 585                 590         


Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr Leu Ala Leu Gln Arg Leu 
        595                 600                 605             


Met Asp Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro Val 
    610                 615                 620                 


Leu Gln His Ser Gln Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser 
625                 630                 635                 640 


Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu Phe Trp 
                645                 650                 655     


Gln Thr Leu Arg Asn Val Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn 
            660                 665                 670         


Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr 
        675                 680         


<210>  143
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TLR2ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  143

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu His 
                325                 330                 335     


Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp Leu Gln 
            340                 345                 350         


Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys Tyr Asp 
        355                 360                 365             


Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu Asn Leu 
    370                 375                 380                 


Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu Cys Leu 
385                 390                 395                 400 


His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn Ile Ile 
                405                 410                 415     


Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser Glu Asn 
            420                 425                 430         


Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser His Phe 
        435                 440                 445             


Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu Leu Glu 
    450                 455                 460                 


Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu Arg Lys 
465                 470                 475                 480 


Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu Ala Gln 
                485                 490                 495     


Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser Arg Val 
            500                 505                 510         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        515                 520                 525             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    530                 535                 540                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
545                 550                 555                 560 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                565                 570                 575     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            580                 585                 590         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        595                 600                 605             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620             


<210>  144
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-CD3zICD-TLR2ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  144

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp Leu 
    450                 455                 460                 


Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys Tyr 
465                 470                 475                 480 


Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu Asn 
                485                 490                 495     


Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu Cys 
            500                 505                 510         


Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn Ile 
        515                 520                 525             


Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser Glu 
    530                 535                 540                 


Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser His 
545                 550                 555                 560 


Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu Leu 
                565                 570                 575     


Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu Arg 
            580                 585                 590         


Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu Ala 
        595                 600                 605             


Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
    610                 615                 620             


<210>  145
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TLR8ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  145

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu His 
                325                 330                 335     


His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu Ala 
            340                 345                 350         


Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp 
        355                 360                 365             


Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val 
    370                 375                 380                 


Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn Val 
385                 390                 395                 400 


Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile 
                405                 410                 415     


Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe Val 
            420                 425                 430         


Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr 
        435                 440                 445             


Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile Phe 
    450                 455                 460                 


Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu Arg 
465                 470                 475                 480 


Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys 
                485                 490                 495     


Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr Glu 
            500                 505                 510         


Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr 
        515                 520                 525             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    530                 535                 540                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
545                 550                 555                 560 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                565                 570                 575     


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            580                 585                 590         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        595                 600                 605             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    610                 615                 620                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
625                 630                 635                 640 


Arg 
    


<210>  146
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-CD3zICD-TLR8ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  146

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu 
    450                 455                 460                 


Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr 
465                 470                 475                 480 


Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp 
                485                 490                 495     


Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn 
            500                 505                 510         


Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile 
        515                 520                 525             


Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe 
    530                 535                 540                 


Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe 
545                 550                 555                 560 


Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile 
                565                 570                 575     


Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu 
            580                 585                 590         


Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro 
        595                 600                 605             


Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr 
    610                 615                 620                 


Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln 
625                 630                 635                 640 


Tyr 
    


<210>  147
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TRAF6ICD-CD3zICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  147

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Met 
                325                 330                 335     


Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu Ser 
            340                 345                 350         


Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys Asp 
        355                 360                 365             


Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser Phe 
    370                 375                 380                 


Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu Glu 
385                 390                 395                 400 


Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala Val 
                405                 410                 415     


Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys Ser 
            420                 425                 430         


Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu Leu 
        435                 440                 445             


Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu Ser 
    450                 455                 460                 


Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu Leu 
465                 470                 475                 480 


Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met Asp 
                485                 490                 495     


Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile His 
            500                 505                 510         


Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys Ala 
        515                 520                 525             


Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys Pro 
    530                 535                 540                 


Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg Glu 
545                 550                 555                 560 


Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile Pro 
                565                 570                 575     


Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn His 
            580                 585                 590         


Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met Leu 
        595                 600                 605             


Ala Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
    610                 615                 620                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
625                 630                 635                 640 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                645                 650                 655     


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            660                 665                 670         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        675                 680                 685             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    690                 695                 700                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
705                 710                 715                 720 


Pro Arg 
        


<210>  148
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-CD3zICD-TRAF6ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  148

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu 
    450                 455                 460                 


Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys 
465                 470                 475                 480 


Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser 
                485                 490                 495     


Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu 
            500                 505                 510         


Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala 
        515                 520                 525             


Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys 
    530                 535                 540                 


Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu 
545                 550                 555                 560 


Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu 
                565                 570                 575     


Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu 
            580                 585                 590         


Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met 
        595                 600                 605             


Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile 
    610                 615                 620                 


His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys 
625                 630                 635                 640 


Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys 
                645                 650                 655     


Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg 
            660                 665                 670         


Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile 
        675                 680                 685             


Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn 
    690                 695                 700                 


His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met 
705                 710                 715                 720 


Leu Ala 
        


<210>  149
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TIM4ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  149

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Met 
                325                 330                 335     


Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu 
            340                 345                 350         


Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly 
        355                 360                 365             


Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
    370                 375             


<210>  150
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TIM4ICD-TLR2-CD3z


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  150

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu Asp 
            340                 345                 350         


Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly Arg 
        355                 360                 365             


Glu Asp Glu Asp Gly Leu Phe Thr Leu His Arg Phe His Gly Leu Trp 
    370                 375                 380                 


Tyr Met Lys Met Met Trp Ala Trp Leu Gln Ala Lys Arg Lys Pro Arg 
385                 390                 395                 400 


Lys Ala Pro Ser Arg Asn Ile Cys Tyr Asp Ala Phe Val Ser Tyr Ser 
                405                 410                 415     


Glu Arg Asp Ala Tyr Trp Val Glu Asn Leu Met Val Gln Glu Leu Glu 
            420                 425                 430         


Asn Phe Asn Pro Pro Phe Lys Leu Cys Leu His Lys Arg Asp Phe Ile 
        435                 440                 445             


Pro Gly Lys Trp Ile Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Ser 
    450                 455                 460                 


His Lys Thr Val Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp 
465                 470                 475                 480 


Cys Lys Tyr Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn 
                485                 490                 495     


Asn Asp Ala Ala Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala 
            500                 505                 510         


Ile Pro Gln Arg Phe Cys Lys Leu Arg Lys Ile Met Asn Thr Lys Thr 
        515                 520                 525             


Tyr Leu Glu Trp Pro Met Asp Glu Ala Gln Arg Glu Gly Phe Trp Val 
    530                 535                 540                 


Asn Leu Arg Ala Ala Ile Lys Ser Arg Val Lys Phe Ser Arg Ser Ala 
545                 550                 555                 560 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                565                 570                 575     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            580                 585                 590         


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
        595                 600                 605             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    610                 615                 620                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
625                 630                 635                 640 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                645                 650                 655     


Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665 


<210>  151
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TIM4ICD-CD3z-TLR2


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  151

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu Asp 
            340                 345                 350         


Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly Arg 
        355                 360                 365             


Glu Asp Glu Asp Gly Leu Phe Thr Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg His Arg Phe His Gly Leu 
                485                 490                 495     


Trp Tyr Met Lys Met Met Trp Ala Trp Leu Gln Ala Lys Arg Lys Pro 
            500                 505                 510         


Arg Lys Ala Pro Ser Arg Asn Ile Cys Tyr Asp Ala Phe Val Ser Tyr 
        515                 520                 525             


Ser Glu Arg Asp Ala Tyr Trp Val Glu Asn Leu Met Val Gln Glu Leu 
    530                 535                 540                 


Glu Asn Phe Asn Pro Pro Phe Lys Leu Cys Leu His Lys Arg Asp Phe 
545                 550                 555                 560 


Ile Pro Gly Lys Trp Ile Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys 
                565                 570                 575     


Ser His Lys Thr Val Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu 
            580                 585                 590         


Trp Cys Lys Tyr Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu 
        595                 600                 605             


Asn Asn Asp Ala Ala Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys 
    610                 615                 620                 


Ala Ile Pro Gln Arg Phe Cys Lys Leu Arg Lys Ile Met Asn Thr Lys 
625                 630                 635                 640 


Thr Tyr Leu Glu Trp Pro Met Asp Glu Ala Gln Arg Glu Gly Phe Trp 
                645                 650                 655     


Val Asn Leu Arg Ala Ala Ile Lys Ser 
            660                 665 


<210>  152
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TIM4ICD-TLR8-CD3z


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  152

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu Asp 
            340                 345                 350         


Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly Arg 
        355                 360                 365             


Glu Asp Glu Asp Gly Leu Phe Thr Leu His His Leu Phe Tyr Trp Asp 
    370                 375                 380                 


Val Trp Phe Ile Tyr Asn Val Cys Leu Ala Lys Val Lys Gly Tyr Arg 
385                 390                 395                 400 


Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp 
                405                 410                 415     


Thr Lys Asp Ala Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr 
            420                 425                 430         


His Leu Glu Glu Ser Arg Asp Lys Asn Val Leu Leu Cys Leu Glu Glu 
        435                 440                 445             


Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln Ser 
    450                 455                 460                 


Ile Asn Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr Ala 
465                 470                 475                 480 


Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr Leu Ala Leu Gln Arg Leu 
                485                 490                 495     


Met Asp Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro Val 
            500                 505                 510         


Leu Gln His Ser Gln Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser 
        515                 520                 525             


Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu Phe Trp 
    530                 535                 540                 


Gln Thr Leu Arg Asn Val Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn 
545                 550                 555                 560 


Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr Arg Val Lys Phe Ser Arg 
                565                 570                 575     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            580                 585                 590         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        595                 600                 605             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
    610                 615                 620                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
625                 630                 635                 640 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                645                 650                 655     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            660                 665                 670         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680             


<210>  153
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TIM4ICD-CD3z-TLR8


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  153

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu Asp 
            340                 345                 350         


Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly Arg 
        355                 360                 365             


Glu Asp Glu Asp Gly Leu Phe Thr Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg His His Leu Phe Tyr Trp 
                485                 490                 495     


Asp Val Trp Phe Ile Tyr Asn Val Cys Leu Ala Lys Val Lys Gly Tyr 
            500                 505                 510         


Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr 
        515                 520                 525             


Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg 
    530                 535                 540                 


Tyr His Leu Glu Glu Ser Arg Asp Lys Asn Val Leu Leu Cys Leu Glu 
545                 550                 555                 560 


Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln 
                565                 570                 575     


Ser Ile Asn Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr 
            580                 585                 590         


Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr Leu Ala Leu Gln Arg 
        595                 600                 605             


Leu Met Asp Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro 
    610                 615                 620                 


Val Leu Gln His Ser Gln Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys 
625                 630                 635                 640 


Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu Phe 
                645                 650                 655     


Trp Gln Thr Leu Arg Asn Val Val Leu Thr Glu Asn Asp Ser Arg Tyr 
            660                 665                 670         


Asn Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr 
        675                 680             


<210>  154
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TLR2ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  154

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu Asp 
            340                 345                 350         


Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly Arg 
        355                 360                 365             


Glu Asp Glu Asp Gly Leu Phe Thr Leu His Arg Phe His Gly Leu Trp 
    370                 375                 380                 


Tyr Met Lys Met Met Trp Ala Trp Leu Gln Ala Lys Arg Lys Pro Arg 
385                 390                 395                 400 


Lys Ala Pro Ser Arg Asn Ile Cys Tyr Asp Ala Phe Val Ser Tyr Ser 
                405                 410                 415     


Glu Arg Asp Ala Tyr Trp Val Glu Asn Leu Met Val Gln Glu Leu Glu 
            420                 425                 430         


Asn Phe Asn Pro Pro Phe Lys Leu Cys Leu His Lys Arg Asp Phe Ile 
        435                 440                 445             


Pro Gly Lys Trp Ile Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Ser 
    450                 455                 460                 


His Lys Thr Val Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp 
465                 470                 475                 480 


Cys Lys Tyr Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn 
                485                 490                 495     


Asn Asp Ala Ala Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala 
            500                 505                 510         


Ile Pro Gln Arg Phe Cys Lys Leu Arg Lys Ile Met Asn Thr Lys Thr 
        515                 520                 525             


Tyr Leu Glu Trp Pro Met Asp Glu Ala Gln Arg Glu Gly Phe Trp Val 
    530                 535                 540                 


Asn Leu Arg Ala Ala Ile Lys Ser 
545                 550         


<210>  155
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TLR8ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  155

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Arg 
                325                 330                 335     


Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu Asp 
            340                 345                 350         


Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly Arg 
        355                 360                 365             


Glu Asp Glu Asp Gly Leu Phe Thr Leu His His Leu Phe Tyr Trp Asp 
    370                 375                 380                 


Val Trp Phe Ile Tyr Asn Val Cys Leu Ala Lys Val Lys Gly Tyr Arg 
385                 390                 395                 400 


Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp 
                405                 410                 415     


Thr Lys Asp Ala Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr 
            420                 425                 430         


His Leu Glu Glu Ser Arg Asp Lys Asn Val Leu Leu Cys Leu Glu Glu 
        435                 440                 445             


Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile Asp Asn Leu Met Gln Ser 
    450                 455                 460                 


Ile Asn Gln Ser Lys Lys Thr Val Phe Val Leu Thr Lys Lys Tyr Ala 
465                 470                 475                 480 


Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr Leu Ala Leu Gln Arg Leu 
                485                 490                 495     


Met Asp Glu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro Val 
            500                 505                 510         


Leu Gln His Ser Gln Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser 
        515                 520                 525             


Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys Ala Glu Gly Leu Phe Trp 
    530                 535                 540                 


Gln Thr Leu Arg Asn Val Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn 
545                 550                 555                 560 


Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr 
                565                 570 


<210>  156
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E7 TCRB chain-P2A-TCRa chain; amino acids 309-335 P2A 
       sequence

<400>  156

Met Ala Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Trp Arg Gly Gly Arg Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr Thr 
            340                 345                 350         


Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly Ala 
        355                 360                 365             


Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly Leu 
    370                 375                 380                 


Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser Tyr 
385                 390                 395                 400 


Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe Leu 
                405                 410                 415     


Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln Met 
            420                 425                 430         


Lys Asp Ser Ala Ser Tyr Leu Cys Ala Ser Val Asp Gly Asn Asn Arg 
        435                 440                 445             


Leu Ala Phe Gly Lys Gly Asn Gln Val Val Val Ile Pro Asn Ile Gln 
    450                 455                 460                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
465                 470                 475                 480 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                485                 490                 495     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
            500                 505                 510         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        515                 520                 525             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    530                 535                 540                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
545                 550                 555                 560 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
                565                 570                 575     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            580                 585                 590         


Leu Arg Leu Trp Ser Ser 
        595             


<210>  157
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TLR2ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  157

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu His 
                325                 330                 335     


Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp Leu Gln 
            340                 345                 350         


Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys Tyr Asp 
        355                 360                 365             


Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu Asn Leu 
    370                 375                 380                 


Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu Cys Leu 
385                 390                 395                 400 


His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn Ile Ile 
                405                 410                 415     


Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser Glu Asn 
            420                 425                 430         


Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser His Phe 
        435                 440                 445             


Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu Leu Glu 
    450                 455                 460                 


Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu Arg Lys 
465                 470                 475                 480 


Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu Ala Gln 
                485                 490                 495     


Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
            500                 505                 510 


<210>  158
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIM4-TIM4-TIM4tm-TLR8ICD


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  158

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu His 
                325                 330                 335     


His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu Ala 
            340                 345                 350         


Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr Asp 
        355                 360                 365             


Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val 
    370                 375                 380                 


Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn Val 
385                 390                 395                 400 


Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile 
                405                 410                 415     


Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe Val 
            420                 425                 430         


Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe Tyr 
        435                 440                 445             


Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile Phe 
    450                 455                 460                 


Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu Arg 
465                 470                 475                 480 


Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys 
                485                 490                 495     


Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr Glu 
            500                 505                 510         


Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln Tyr 
        515                 520                 525             


