                         SEQUENCE LISTING

<110>  EpiVax, Inc.
 
<120>  Regulatory T Cell Epitopes

<130>  EPV0044WO

<150>  US 63/065,029
<151>  2020-08-13

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser His Arg Leu Leu Ala Val Cys Ala Leu Val Ser Leu Ala Thr Ala 
1               5                   10                  15      


Ala 
    


<210>  2
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser His Arg Leu Leu Ala Val Cys Ala Leu Val Ser Leu Ala Thr Ala 
1               5                   10                  15      


Ala Leu Leu Gly His Ile 
            20          


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Ala Ala Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile 
1               5                   10                  15      


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
1               5                   10                  15  


<210>  5
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu 
1               5                   10                  15      


Gln 
    


<210>  6
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr 
1               5                   10                  15      


Ala Pro Gln Gln Val Leu 
            20          


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Pro Arg Glu Leu Ser Gly Ser Ser Pro Val Leu Glu Glu Thr His 
1               5                   10                  15  


<210>  8
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Gly His Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu 
1               5                   10                  15      


Ser Gly Ser Ser 
            20  


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser His Arg Leu Leu Ala Val Cys Ala 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

His Arg Leu Leu Ala Val Cys Ala Leu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Leu Leu Ala Val Cys Ala Leu Val 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Leu Ala Val Cys Ala Leu Val Ser 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Ala Val Cys Ala Leu Val Ser Leu 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Val Cys Ala Leu Val Ser Leu Ala 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Val Cys Ala Leu Val Ser Leu Ala Thr 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Ala Leu Val Ser Leu Ala Thr Ala 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Leu Val Ser Leu Ala Thr Ala Ala 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Leu Val Ser Leu Ala Thr Ala Ala Leu 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Val Ser Leu Ala Thr Ala Ala Leu Leu 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Leu Ala Thr Ala Ala Leu Leu Gly 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Ala Thr Ala Ala Leu Leu Gly His 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Thr Ala Ala Leu Leu Gly His Ile 
1               5                   


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  23

Lys Asp Ile Leu Thr Leu Arg Asp 
1               5               


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Ile Leu Thr Leu Arg Leu Asp Val 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Ile Leu Thr Leu Arg Leu Asp Val Met 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Thr Leu Arg Leu Asp Val Met Met 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Thr Leu Arg Leu Asp Val Met Met Glu 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Leu Arg Leu Asp Val Met Met Glu Thr 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Leu Asp Val Met Met Glu Thr Glu 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala His Gly Val Phe Leu Leu Asn Ser 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  31

His Gly Val Phe Leu Leu Asn Ser Asn 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Val Phe Leu Leu Asn Ser Asn Ala 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  33

Val Phe Leu Leu Asn Ser Asn Ala Met 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  34

Phe Leu Leu Asn Ser Asn Ala Met Asp 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  35

Leu Leu Ser Asn Asn Ala Met Asp Val 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  36

Leu Asn Ser Asn Ala Met Asp Val Val 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Asn Ser Asn Ala Met Asp Val Val Leu 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Asn Ala Met Asp Val Val Leu Gln 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Ala Gly Leu Gln Leu Gln Lys Val 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Gly Leu Gln Leu Gln Lys Val Thr 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Leu Gln Leu Gln Lys Val Thr Val 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Gln Leu Gln Lys Val Thr Val Leu 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Leu Gln Lys Val Thr Val Leu Gly 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Leu Gln Lys Val Thr Val Leu Gly Val 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  45

Gln Lys Val Thr Val Leu Gly Val Ala 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  46

Lys Val Thr Val Leu Gly Val Ala Thr 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  47

Val Thr Val Leu Gly Val Ala Thr Ala 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  48

Thr Val Leu Gly Val Ala Thr Ala Pro 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  49

Val Leu Gly Val Ala Thr Ala Pro Gln 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  50

Leu Gly Val Ala Thr Ala Pro Gln Gln 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  51

Gly Val Ala Thr Ala Pro Gln Gln Val 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  52

Val Ala Thr Ala Pro Gln Gln Val Leu 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Ala Ala Ala Leu Val Ser Leu Ala Thr 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Ala Ala Leu Val Ser Leu Ala Thr Ala 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  55

Pro Arg Glu Leu Ser Gly Ser Ser Pro 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  56

Arg Glu Leu Ser Gly Ser Ser Pro Val 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  57

Glu Leu Ser Gly Ser Ser Pro Val Leu 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  58

Leu Ser Gly Ser Ser Pro Val Leu Glu 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Gly Ser Ser Pro Val Leu Glu Glu 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Ser Ser Pro Val Leu Glu Glu Thr 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  61

Ser Ser Pro Val Leu Glu Glu Thr His 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  62

Leu Gly His Ile Leu Leu His Asp Phe 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly His Ile Leu Leu His Asp Phe Leu 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

His Ile Leu Leu His Asp Phe Leu Leu 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  65

Ile Leu Leu His Asp Phe Leu Leu Val 
1               5                   


<210>  66
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  66

Ile Leu Leu His Asp Phe Leu Leu Val Pro 
1               5                   10  


<210>  67
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  67

Leu His Asp Phe Leu Leu Val Pro Arg 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  68

His Asp Phe Leu Leu Val Pro Arg Glu 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  69

Asp Phe Leu Leu Val Pro Arg Glu Leu 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  70

Phe Leu Leu Val Pro Arg Glu Leu Ser 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  71

Leu Leu Val Pro Arg Glu Leu Ser Gly 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Val Pro Arg Glu Leu Ser Gly Ser 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  73

Val Pro Arg Glu Leu Ser Gly Ser Ser 
1               5                   


<210>  74
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  74

Ile Leu Thr Ile His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys 
1               5                   10                  15  


<210>  75
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  75

Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly 
1               5                   10                  15      


Tyr Thr 
        


<210>  76
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  76

Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
1               5                   10                  15      


Pro Lys Asp 
            


<210>  77
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  77

Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile 
1               5                   10                  15      


Gly Thr 
        


<210>  78
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser 
1               5                   10                  15      


Thr 
    


<210>  79
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  79

Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
1               5                   10                  15      


Leu Thr Glu Ala 
            20  


<210>  80
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  80

Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly 
1               5                   10                  15  


<210>  81
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  81

Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val 
1               5                   10                  15      


Gly Ala Asp 
            


<210>  82
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  82

Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg 
1               5                   10                  15  


<210>  83
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  83

Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser 
1               5                   10                  15      


Leu Pro Gln Glu Pro Tyr 
            20          


<210>  84
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  84

Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro 
1               5                   10                  15      


His Leu Tyr Thr Leu Phe His 
            20              


<210>  85
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  85

Leu Tyr Thr Leu Phe His Gln Gln Ala His Val Ala Gly Glu Thr Val 
1               5                   10                  15      


Ala 
    


<210>  86
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  86

Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu 
1               5                   10                  15      


Leu Val Arg Val Thr Ser Glu Gly Ala 
            20                  25  


<210>  87
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  87

Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn 
1               5                   10                  15      


Phe Thr 
        


<210>  88
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  88

Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu 
1               5                   10                  15      


Pro Gln Glu Pro Tyr Ser 
            20          


<210>  89
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  89

Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile 
1               5                   10                  15      


Thr 
    


<210>  90
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  90

Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val 
1               5                   10                  15      


Gly Ala Asp 
            


<210>  91
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  91

Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
1               5                   10                  15      


Leu Leu 
        


<210>  92
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  92

Lys Lys Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe 
1               5                   10                  15      


Ala Asp 
        


<210>  93
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  93

Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr 
1               5                   10                  15      


Thr 
    


<210>  94
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  94

Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp 
1               5                   10                  15      


<210>  95
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  95

Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala 
1               5                   10              


<210>  96
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  96

Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
1               5                   10                  15      


Leu Thr Glu Ala 
            20  


<210>  97
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  97

Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly 
1               5                   10                  15      


Leu Gln 
        


<210>  98
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  98

Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val 
1               5                   10                  


<210>  99
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  99

Ala Ala Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg 
1               5                   10                  15  


<210>  100
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  100

Val Cys Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile 
1               5                   10                  15      


<210>  101
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  102
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys Ala Ala Ala Leu Val Ser Leu Ala 
945                 950                 955                 960 


Thr Ala Ala Leu Leu Gly His Ile 
                965             


<210>  103
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  103

Ala Ala Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile 
1               5                   10                  15      


Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
            20                  25                  30          


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
        35                  40                  45              


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
    50                  55                  60                  


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
65                  70                  75                  80  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
                85                  90                  95      


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
            100                 105                 110         


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
        115                 120                 125             


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
    130                 135                 140                 


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
145                 150                 155                 160 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
                165                 170                 175     


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
            180                 185                 190         


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
        195                 200                 205             


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
    210                 215                 220                 


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
225                 230                 235                 240 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
                245                 250                 255     


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
            260                 265                 270         


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
        275                 280                 285             


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
    290                 295                 300                 


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
305                 310                 315                 320 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
                325                 330                 335     


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
            340                 345                 350         


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
        355                 360                 365             


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
    370                 375                 380                 


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
385                 390                 395                 400 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
                405                 410                 415     


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
            420                 425                 430         


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
        435                 440                 445             


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
    450                 455                 460                 


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
465                 470                 475                 480 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
                485                 490                 495     


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
            500                 505                 510         


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
        515                 520                 525             


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
    530                 535                 540                 


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
545                 550                 555                 560 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
                565                 570                 575     


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
            580                 585                 590         


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
        595                 600                 605             


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
    610                 615                 620                 


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
625                 630                 635                 640 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
                645                 650                 655     


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
            660                 665                 670         


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
        675                 680                 685             


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
    690                 695                 700                 


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
705                 710                 715                 720 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
                725                 730                 735     


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
            740                 745                 750         


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
        755                 760                 765             


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
    770                 775                 780                 


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
785                 790                 795                 800 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
                805                 810                 815     


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
            820                 825                 830         


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
        835                 840                 845             


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
    850                 855                 860                 


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
865                 870                 875                 880 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
                885                 890                 895     


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
            900                 905                 910         


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
        915                 920                 925             


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
    930                 935                 940                 


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
945                 950                 955                 960 


Glu Gln Phe Leu Val Ser Trp Cys 
                965             


<210>  104
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Ala Ala 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  105
<211>  985
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys Ala Ala Ala Leu Val Ser Leu Ala 
945                 950                 955                 960 


Thr Ala Ala Leu Leu Gly His Ile Ala His Gly Val Phe Leu Leu Asn 
                965                 970                 975     


Ser Asn Ala Met Asp Val Val Leu Gln 
            980                 985 


<210>  106
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  106

Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln 
1               5                   10                  15  


