                         SEQUENCE LISTING

<110>  Orchard Therapeutics (Europe) Limited
 
<120>  COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HEREDITARY 
       ANGIOEDEMA

<130>  51139-026WO2

<150>  US 63/066,011
<151>  2020-08-14

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1500
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga tcttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc cagatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500


<210>  2
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


