                         SEQUENCE LISTING

<110>  A2 BIOTHERAPEUTICS, INC.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCERS

<130>  A2BI-018/01WO 331656-2073

<150>  US 63/065,324
<151>  2020-08-13

<160>  139   

<170>  PatentIn version 3.5

<210>  1
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Met Ile Gly Val Leu Val Gly Val 
1               5                   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR alpha chain variable domain CDR-1

<400>  3

Thr Ser Ile Thr Ala 
1               5   


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR alpha chain variable domain CDR-2

<400>  4

Ile Arg Ser Asn Glu Arg 
1               5       


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR alpha chain variable domain CDR-3

<400>  5

Ala Thr Asp Leu Thr Ser Gly Gly Asn Tyr Lys 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR alpha chain variable domain CDR-3

<400>  6

Ala Thr Asp Phe Thr Ser Gly Gly Asn Tyr Lys 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR alpha chain variable domain CDR-3

<400>  7

Ala Thr Asp Leu Thr Thr Gly Gly Asn Tyr Lys 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR alpha chain variable domain CDR-3

<400>  8

Ala Thr Asp Phe Thr Thr Gly Gly Asn Tyr Lys 
1               5                   10      


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR beta chain variable domain CDR-1

<400>  9

Lys Gly His Pro Val 
1               5   


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR beta chain variable domain CDR-2

<400>  10

Phe Gln Asn Gln Glu Val 
1               5       


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR beta chain variable domain CDR-3

<400>  11

Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCR beta chain variable domain CDR-3

<400>  12

Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln 
1               5                   10      


<210>  13
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  13
gactttattc tggaagatgc tgcttctcca aagtgcatta tgaaggaaaa aaaaaagcct       60

ggtgagactt tcttc                                                        75


<210>  14
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu 
1               5                   10                  15      


Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            20                  25  


<210>  15
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Glu 
305                 310                 315                 320 


Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp 
                325                 330                 335     


Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr 
            340                 345                 350         


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu 
        355                 360                 365             


Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg 
    370                 375                 380                 


Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val 
385                 390                 395                 400 


Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp 
                405                 410                 415     


Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu 
            420                 425                 430         


Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp 
        435                 440                 445             


Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser 
    450                 455                 460                 


Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn 
465                 470                 475                 480 


Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser 
                485                 490                 495     


Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val 
            500                 505                 510         


Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn 
        515                 520                 525             


Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro 
    530                 535                 540                 


Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val 
545                 550                 555                 560 


Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val 
                565                 570                 575     


Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro 
            580                 585                 590         


Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala 
        595                 600                 605             


Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr 
    610                 615                 620                 


Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe 
625                 630                 635                 640 


Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val 
                645                 650                 655     


Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr 
            660                 665                 670         


Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val 
        675                 680                 685             


Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700     


<210>  16
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 548: pLenti 1 CEA TCR TRAV8-1*01 118P & 119T with murine 
       constant region

<400>  16

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Ser Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  17
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 549: pLenti 1 CEA TCR TRAV8-1*01 118P & 119T TRBV26*01 L117T 
       with murine constant region

<400>  17

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Ser Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  18
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 550: pLenti 1 CEA TCR TRAV8-1*01 118P & 119T with murine 
       constant region

<400>  18

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Ser Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  19
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 551: pLenti 1 CEA TCR TRAV8-1*01 L110F 118P & 119T with 
       murine constant region

<400>  19

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Ser Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  20
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 552: pLenti 1 CEA TCR TRAV8-1*01 S112T 118P & 119T with 
       murine constant region

<400>  20

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Thr Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  21
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 553: pLenti 1 CEA TCR TRAV8-1*01 L110F S112T 118P & 119T 
       with murine constant region

<400>  21

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Thr Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  22
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 554: pLenti 1 CEA TCR TRAV8-1*01 L110F 118P & 119T TRBV26*01 
       L117T with murine constant region

<400>  22

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Ser Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  23
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 555: pLenti 1 CEA TCR TRAV8-1*01 S112T 118P & 119T TRBV26*01 
       L117T with murine constant region

<400>  23

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Thr Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  24
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 556: pLenti 1 CEA TCR TRAV8-1*01 L110F S112T 118P & 119T TRBV26*01 
       L117T with murine constant region

<400>  24

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Thr Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  25
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 557: pLenti 1 CEA TCR TRAV8-1*01 L110F 118P & 119T with murine 
       constant region

<400>  25

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Ser Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  26
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 558: pLenti 1 CEA TCR TRAV8-1*01 S112T 118P & 119T with 
       murine constant region

<400>  26

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Thr Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  27
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 559: pLenti 1 CEA TCR TRAV8-1*01 L110F S112T 118P & 119T 
       with murine constant region

<400>  27

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Thr Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  28
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 560: pLenti 1 CEA TCR TRAV8-1*01 118P & 119T TRBV26*01 L117T 
       with murine constant region

<400>  28

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Ser Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  29
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 561: pLenti 1 CEA TCR TRAV8-1*01 L110F 118P & 119T TRBV26*01 
       L117T with murine constant region

<400>  29

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Ser Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  30
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 562: pLenti 1 CEA TCR TRAV8-1*01 S112T 118P & 119T TRBV26*01 
       L117T with murine constant region

<400>  30

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Thr Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  31
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 563: pLenti 1 CEA TCR TRAV8-1*01 L110F S112T 118P & 119T 
       TRBV26*01 L117T with murine constant region

<400>  31

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Thr Gly Gly Asn Tyr Lys Pro Thr Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Val Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg 
305                 310                 315                 320 


Tyr Leu Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro 
                325                 330                 335     


Glu Lys Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn 
            340                 345                 350         


Glu Phe Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln 
        355                 360                 365             


Ile Asp Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser 
    370                 375                 380                 


Pro Cys Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  32
<211>  19
<212>  PRT
<213>  Unknown

<220>  
<223>  P2A self-cleaving peptide

<400>  32

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  33
<211>  18
<212>  PRT
<213>  Unknown

<220>  
<223>  T2A self-cleaving peptide

<400>  33

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  34
<211>  20
<212>  PRT
<213>  Unknown

<220>  
<223>  E2A self-cleaving peptide

<400>  34

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  35
<211>  22
<212>  PRT
<213>  Unknown

<220>  
<223>  F2A self-cleaving peptide

<400>  35

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  36
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 532: pLenti 1 CEA TCR TRAV8-1*01 TRBV26*01 with regular 
       murine constant region

<400>  36

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Ser Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  37
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 533: pLenti 1 CEA TCR TRAV8-1*01 TRBV26*01 L117T with 
       regular murine constant region

<400>  37

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Ser Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  38
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 534: pLenti 1 CEA TCR TRAV8-1*01 TRBV26*01 murine constant 
       region (no PT)

<400>  38

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Ser Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  39
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 535: pLenti 1 CEA TCR TRAV8-1*01 L110F TRBV26*01 with 
       regular murine constant region

<400>  39

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Ser Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  40
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 536: pLenti 1 CEA TCR TRAV8-1*01 S112T  TRBV26*01 with 
       regular murine constant region

<400>  40

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Thr Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  41
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 537: pLenti 1 CEA TCR TRAV8-1*01 L110F & S112T TRBV26*01 
       with regular murine constant region

<400>  41

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Thr Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  42
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 538: pLenti 1 CEA TCR TRAV8-1*01 L110F TRBV26*01 L117T 
       with regular murine constant region

<400>  42

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Ser Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  43
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 539: pLenti 1 CEA TCR TRAV8-1*01 S112T TRBV26*01 L117T 
       with regular murine constant region

<400>  43

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Thr Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  44
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 540: pLenti 1 CEA TCR TRAV8-1*01 L110F & S112T TRBV26*01 L117T 
       with regular murine constant region

<400>  44

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Thr Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  45
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 541: pLenti 1 CEA TCR TRAV8-1*01 L110F TRBV26*01 with 
       murine constant region

<400>  45

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Ser Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  46
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 542: pLenti 1 CEA TCR TRAV8-1*01 S112T TRBV26*01 with 
       murine constant region

<400>  46

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Thr Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  47
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 543: pLenti 1 CEA TCR TRAV8-1*01 L110F & S112T TRBV26*01 
       with murine constant region

<400>  47

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Thr Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Leu Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  48
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 544: pLenti 1 CEA TCR  TRAV8-1*01 TRBV26*01 L117T with 
       murine constant region

<400>  48

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Ser Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  49
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 545: pLenti 1 CEA TCR TRAV8-1*01 L110F TRBV26*01 L117T 
       with murine constant region

<400>  49

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Ser Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  50
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 546: pLenti 1 CEA TCR TRAV8-1*01 S112T TRBV26*01 L117T 
       with murine constant region

<400>  50

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Leu Thr Thr Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  51
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT 547: pLenti 1 CEA TCR TRAV8-1*01 L110F & S112T TRBV26*01 
       L117T with murine constant region

<400>  51

Met His Ser Leu Leu Gly Leu Leu Met Val Ser Leu Trp Leu Gln Leu 
1               5                   10                  15      


Thr Arg Val Asn Ser Gln Leu Ala Glu Glu Asn Pro Trp Ala Leu Ser 
            20                  25                  30          


Val His Glu Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Thr Ala Leu Gln Trp Tyr Arg Gln Lys Ser Gly Glu Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Ala Thr Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Phe Thr Thr Gly Gly Asn Tyr Lys Phe Gly Lys Gly Thr Ser Leu Val 
        115                 120                 125             


Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu 
305                 310                 315                 320 


Val Lys Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys 
                325                 330                 335     


Gly His Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe 
            340                 345                 350         


Lys Phe Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp 
        355                 360                 365             


Met Thr Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys 
    370                 375                 380                 


Ser Leu Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Ser Leu Gly Thr Gly Asp Tyr Glu Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  52
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CAR with ScFv; CT 618

<400>  52

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Glu Phe Gly Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala 
65                  70                  75                  80  


Thr Tyr Val Glu Glu Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr 
                85                  90                  95      


Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                245                 250                 255     


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly 
    370                 375                 380                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
385                 390                 395                 400 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                405                 410                 415     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            420                 425                 430         


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        435                 440                 445             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    450                 455                 460                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg 
    530                 535 


<210>  53
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CAR with ScFv; CT 619

<400>  53

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Glu Phe Gly Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala 
65                  70                  75                  80  


Thr Tyr Val Glu Glu Phe Lys Gly Arg Val Thr Phe Thr Thr Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                245                 250                 255     


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val 
305                 310                 315                 320 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
                325                 330                 335     


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys 
    370                 375                 380                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
385                 390                 395                 400 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                405                 410                 415     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            420                 425                 430         


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        435                 440                 445             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    450                 455                 460                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
465                 470                 475                 480 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                485                 490                 495     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            500                 505                 510         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        515                 520                 525             


Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535         


<210>  54
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CAR with ScFv; CT 620

<400>  54

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Glu Phe Gly Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala 
65                  70                  75                  80  


Thr Tyr Val Glu Glu Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr 
                85                  90                  95      


Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Trp Asp Phe Ala His Tyr Phe Gln 
        115                 120                 125             


Thr Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                245                 250                 255     


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg 
    370                 375                 380                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
385                 390                 395                 400 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                405                 410                 415     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            420                 425                 430         


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        435                 440                 445             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    450                 455                 460                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
465                 470                 475                 480 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                485                 490                 495     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            500                 505                 510         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        515                 520                 525             


His Met Gln Ala Leu Pro Pro Arg 
    530                 535     


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv CDR-H1

<400>  55

Glu Phe Gly Met Asn 
1               5   


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv CDR-H2

<400>  56

Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv CDR-H3

<400>  57

Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv CDR-H3

<400>  58

Trp Asp Phe Ala His Tyr Phe Gln Thr Met Asp Tyr 
1               5                   10          


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv CDR-L1

<400>  59

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv CDR-L1

<400>  60

Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala 
1               5                   10      


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv CDR-L2

<400>  61

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv CDR-L2

<400>  62

Ser Ala Ser Tyr Arg Lys Arg 
1               5           


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv CDR-L3

<400>  63

His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr 
1               5                   10  


<210>  64
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; MFE23M

<400>  64

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Asn Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro 
                165                 170                 175     


Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  65
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; MFE23H

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Leu Ala Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  66
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; E8

<400>  66

Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Asn Glu Phe Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val 
    130                 135                 140                 


Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser 
145                 150                 155                 160 


Leu Arg Ser Ser Tyr Ala Ser Trp Tyr Arg Gln Arg Pro Gly Gln Ala 
                165                 170                 175     


Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile 
        195                 200                 205             


Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Trp Asn Ser Ser 
    210                 215                 220                 


Tyr Ala Trp Leu Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  67
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; SM3E

<400>  67

Gln Val Gln Leu Glu Gln Ser Gly Ala Gly Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Asn Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Met Ser Val Ser Val Gly Asp Arg Val Asn Ile Ala Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Pro Tyr Met His Trp Leu Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ser Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  68
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; CT618

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
            180                 185                 190         


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  69
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; CT619

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
            180                 185                 190         


Lys Arg Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  70
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; CT620

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala His Tyr Phe Gln Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
            180                 185                 190         


Lys Arg Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  71
<211>  45
<212>  PRT
<213>  Unknown

<220>  
<223>  CD8alpha hinge

<400>  71

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  72
<211>  135
<212>  DNA
<213>  Unknown

<220>  
<223>  CD8alpha hinge

<400>  72
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  73
<211>  41
<212>  PRT
<213>  Unknown

<220>  
<223>  CD28 hinge

<400>  73

Cys Thr Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
1               5                   10                  15      


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40      


<210>  74
<211>  123
<212>  DNA
<213>  Unknown

<220>  
<223>  CD28 hinge

<400>  74
tgtaccattg aagttatgta tcctcctcct tacctagaca atgagaagag caatggaacc       60

attatccatg tgaaagggaa acacctttgt ccaagtcccc tatttcccgg accttctaag      120

ccc                                                                    123


<210>  75
<211>  27
<212>  PRT
<213>  Unknown

<220>  
<223>  CD28 transmembrane domain

<400>  75

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  76
<211>  81
<212>  DNA
<213>  Unknown

<220>  
<223>  CD28 transmembrane domain

<400>  76
ttctgggtgc tggtcgttgt gggcggcgtg ctggcctgct acagcctgct ggtgacagtg       60

gccttcatca tcttttgggt g                                                 81


<210>  77
<211>  25
<212>  PRT
<213>  Unknown

<220>  
<223>  IL-2Rbeta transmembrane domain

<400>  77

Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210>  78
<211>  75
<212>  DNA
<213>  Unknown

<220>  
<223>  IL-2Rbeta transmembrane domain

<400>  78
attccgtggc tcggccacct cctcgtgggc ctcagcgggg cttttggctt catcatctta       60

gtgtacttgc tgatc                                                        75


<210>  79
<211>  112
<212>  PRT
<213>  Unknown

<220>  
<223>  CD3zeta activation domain

<400>  79

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  80
<211>  336
<212>  DNA
<213>  Unknown

<220>  
<223>  CD3zeta activation domain

<400>  80
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gcgtagaggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggactca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  81
<211>  43
<212>  PRT
<213>  Unknown

<220>  
<223>  CD3zeta activation domain ITAM

<400>  81

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu His Met Gln Ala Leu Pro Pro Arg 
        35                  40              


<210>  82
<211>  129
<212>  DNA
<213>  Unknown

<220>  
<223>  CD3zeta activation domain ITAM

<400>  82
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttgcacat gcaggccctg      120

ccccctcgc                                                              129


<210>  83
<211>  41
<212>  PRT
<213>  Unknown

<220>  
<223>  CD28 co-stimulatory domain

<400>  83

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  84
<211>  123
<212>  DNA
<213>  Unknown

<220>  
<223>  CD28 co-stimulatory domain

<400>  84
aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct       60

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg      120

agc                                                                    123


<210>  85
<211>  23
<212>  PRT
<213>  Unknown

<220>  
<223>  TCR alpha transmembrane domain

<400>  85

Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu Arg Leu Trp 
            20              


<210>  86
<211>  69
<212>  DNA
<213>  Unknown

<220>  
<223>  TCR alpha transmembrane domain

<400>  86
gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg       60

cggctgtgg                                                               69


<210>  87
<211>  23
<212>  PRT
<213>  Unknown

<220>  
<223>  TCR beta transmembrane domain

<400>  87

Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
1               5                   10                  15      


Leu Val Ser Ala Leu Val Leu 
            20              


<210>  88
<211>  69
<212>  DNA
<213>  Unknown

<220>  
<223>  TCR beta transmembrane domain

<400>  88
accatcctct atgagatctt gctagggaag gccaccttgt atgccgtgct ggtcagtgcc       60

ctcgtgctg                                                               69


<210>  89
<211>  10
<212>  PRT
<213>  Unknown

<220>  
<223>  TCR beta intracellular domain

<400>  89

Met Ala Met Val Lys Arg Lys Asp Ser Arg 
1               5                   10  


<210>  90
<211>  30
<212>  DNA
<213>  Unknown

<220>  
<223>  TCR beta intracellular domain

<400>  90
atggccatgg tcaagagaaa ggattccaga                                        30


<210>  91
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Thr Val Thr Tyr Thr Ala Arg Val Ala Asn Ala Arg Phe Gly Gly 
1               5                   10                  15      


Phe Ser Gln Leu Leu Leu Leu Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Trp Arg Glu Leu Leu Cys Phe Leu Gly Phe Tyr Met Ala Leu Ser Ala 
        35                  40                  45              


Ala Tyr Arg Phe Val Leu Thr Glu Gly Gln Lys Arg Tyr Phe Glu Lys 
    50                  55                  60                  


Leu Val Ile Tyr Cys Asp Gln Tyr Ala Ser Leu Ile Pro Val Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp Trp Ser Gln 
                85                  90                  95      


Tyr Leu Cys Met Pro Leu Pro Asp Ala Leu Met Cys Val Val Ala Gly 
            100                 105                 110         


Thr Val His Gly Arg Asp Asp Arg Gly Arg Leu Tyr Arg Arg Thr Leu 
        115                 120                 125             


Met Arg Tyr Ala Gly Leu Ser Ala Val Leu Ile Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Phe Lys Arg Phe Pro Thr Ile Asp His Val Val Glu Ala 
145                 150                 155                 160 


Gly Phe Met Thr Arg Glu Glu Arg Lys Lys Phe Glu Asn Leu Asn Ser 
                165                 170                 175     


Ser Tyr Asn Lys Tyr Trp Val Pro Cys Val Trp Phe Ser Asn Leu Ala 
            180                 185                 190         


Ala Gln Ala Arg Arg Glu Gly Arg Ile Arg Asp Asn Ser Ala Leu Lys 
        195                 200                 205             


Leu Leu Leu Glu Glu Leu Asn Val Phe Arg Gly Lys Cys Gly Met Leu 
    210                 215                 220                 


Phe His Tyr Asp Trp Ile Ser Val Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Ile Ala Leu Tyr Ser Tyr Phe Leu Ala Cys Leu Ile Gly Arg Gln 
                245                 250                 255     


Phe Leu Asp Pro Ala Gln Gly Tyr Lys Asp His Asp Leu Asp Leu Cys 
            260                 265                 270         


Val Pro Ile Phe Thr Leu Leu Gln Phe Phe Phe Tyr Ala Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Phe Leu Ile Asp Arg Asn Phe Gln Val Ser Met Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met Tyr Asp Asp Leu Ala Val Leu Glu Lys Asp Leu 
                325                 330                 335     


Tyr Trp Asp Ala Ala Glu Ala Arg Ala Pro Tyr Thr Ala Ala Thr Val 
            340                 345                 350         


Phe Gln Leu Arg Gln Pro Ser Phe Gln Gly Ser Thr Phe Asp Ile Thr 
        355                 360                 365             


Leu Ala Lys Glu Asp Met Gln Phe Gln Arg Leu Asp Gly Leu Asp Gly 
    370                 375                 380                 


Pro Met Gly Glu Ala Pro Gly Asp Phe Leu Gln Arg Leu Leu Pro Ala 
385                 390                 395                 400 


Gly Ala Gly Met Val Ala Gly Gly Pro Leu Gly Arg Arg Leu Ser Phe 
                405                 410                 415     


Leu Leu Arg Lys Asn Ser Cys Val Ser Glu Ala Ser Thr Gly Ala Ser 
            420                 425                 430         


Cys Ser Cys Ala Val Val Pro Glu Gly Ala Ala Pro Glu Cys Ser Cys 
        435                 440                 445             


Gly Asp Pro Leu Leu Asp Pro Gly Leu Pro Glu Pro Glu Ala Pro Pro 
    450                 455                 460                 


Pro Ala Gly Pro Glu Pro Leu Thr Leu Ile Pro Gly Pro Val Glu Pro 
465                 470                 475                 480 


Phe Ser Ile Val Thr Met Pro Gly Pro Arg Gly Pro Ala Pro Pro Trp 
                485                 490                 495     


Leu Pro Ser Pro Ile Gly Glu Glu Glu Glu Asn Leu Ala 
            500                 505                 


<210>  92
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Thr Val Ser Tyr Thr Leu Lys Val Ala Glu Ala Arg Phe Gly Gly 
1               5                   10                  15      


Phe Ser Gly Leu Leu Leu Arg Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Lys Glu Phe Leu Leu Phe Gly Ala Leu Tyr Ala Val Leu Ser Ile 
        35                  40                  45              


Thr Tyr Arg Leu Leu Leu Thr Gln Glu Gln Arg Tyr Val Tyr Ala Gln 
    50                  55                  60                  


Val Ala Arg Tyr Cys Asn Arg Ser Ala Asp Leu Ile Pro Leu Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp Trp Ser Gln 
                85                  90                  95      


Tyr Thr Ser Ile Pro Leu Pro Asp Gln Leu Met Cys Val Ile Ser Ala 
            100                 105                 110         


Ser Val His Gly Val Asp Gln Arg Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Ile Arg Tyr Ala Asn Leu Ala Ser Val Leu Val Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Arg Val Leu Lys Arg Phe Pro Thr Met Glu His Val Val Asp Ala 
145                 150                 155                 160 


Gly Phe Met Ser Gln Glu Glu Arg Lys Lys Phe Glu Ser Leu Lys Ser 
                165                 170                 175     


Asp Phe Asn Lys Tyr Trp Val Pro Cys Val Trp Phe Thr Asn Leu Ala 
            180                 185                 190         


Ala Gln Ala Arg Arg Asp Gly Arg Ile Arg Asp Asp Ile Ala Leu Cys 
        195                 200                 205             


Leu Leu Leu Glu Glu Leu Asn Lys Tyr Arg Ala Lys Cys Ser Met Leu 
    210                 215                 220                 


Phe His Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Ile Ala Val Tyr Ser Phe Phe Ala Leu Ser Leu Val Gly Arg Gln 
                245                 250                 255     


Phe Val Glu Pro Glu Ala Gly Ala Ala Lys Pro Gln Lys Leu Leu Lys 
            260                 265                 270         


Pro Gly Gln Glu Pro Ala Pro Ala Leu Gly Asp Pro Asp Met Tyr Val 
        275                 280                 285             


Pro Leu Thr Thr Leu Leu Gln Phe Phe Phe Tyr Ala Gly Trp Leu Lys 
    290                 295                 300                 


Val Ala Glu Gln Ile Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp Phe 
305                 310                 315                 320 


Glu Thr Asn Gln Leu Ile Asp Arg Asn Leu Gln Val Ser Leu Leu Ser 
                325                 330                 335     


Val Asp Glu Met Tyr Gln Asn Leu Pro Pro Ala Glu Lys Asp Gln Tyr 
            340                 345                 350         


Trp Asp Glu Asp Gln Pro Gln Pro Pro Tyr Thr Val Ala Thr Ala Ala 
        355                 360                 365             


Glu Ser Leu Arg Pro Ser Phe Leu Gly Ser Thr Phe Asn Leu Arg Met 
    370                 375                 380                 


Ser Asp Asp Pro Glu Gln Ser Leu Gln Val Glu Ala Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Arg Pro Ala Pro Ala Ala Gln Thr Pro Leu Leu Gly Arg Phe Leu 
                405                 410                 415     


Gly Val Gly Ala Pro Ser Pro Ala Ile Ser Leu Arg Asn Phe Gly Arg 
            420                 425                 430         


Val Arg Gly Thr Pro Arg Pro Pro His Leu Leu Arg Phe Arg Ala Glu 
        435                 440                 445             


Glu Gly Gly Asp Pro Glu Ala Ala Ala Arg Ile Glu Glu Glu Ser Ala 
    450                 455                 460                 


Glu Ser Gly Asp Glu Ala Leu Glu Pro 
465                 470             


<210>  93
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr 
1               5                   10                  15      


Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu 
            20                  25                  30          


Asn Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys 
        35                  40                  45              


Cys Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly 
    50                  55                  60                  


Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala 
65                  70                  75                  80  


Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg 
                85                  90                  95      


Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu 
            100                 105                 110         


Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val 
        115                 120                 125             


Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly 
    130                 135                 140                 


Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala 
145                 150                 155                 160 


Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln 
                165                 170                 175     


Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser 
            180                 185                 190         


Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly 
        195                 200                 205             


Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly 
    210                 215                 220                 


Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu 
225                 230                 235                 240 


His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser 
                245                 250                 255     


Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln 
            260                 265                 270         


Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg 
        275                 280                 285             


Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala 
    290                 295                 300                 


Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu 
305                 310                 315                 320 


Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly 
                325                 330                 335     


Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys 
            340                 345                 350         


Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg 
        355                 360                 365             


Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala 
    370                 375                 380                 


Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly 
385                 390                 395                 400 


Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr 
                405                 410                 415     


Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg 
            420                 425                 430         


Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe 
        435                 440                 445             


Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly 
    450                 455                 460                 


Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr 
465                 470                 475                 480 


Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
                485                 490                 495 


<210>  94
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile 
1               5                   10                  15      


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu 
            20                  25                  30          


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn 
    50                  55                  60                  


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn 
65                  70                  75                  80  


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln 
                85                  90                  95      


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu 
            100                 105                 110         


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr 
        115                 120                 125             


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val 
    130                 135                 140                 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu 
145                 150                 155                 160 


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro 
                165                 170                 175     


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys 
            180                 185                 190         


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile 
        195                 200                 205             


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe 
    210                 215                 220                 


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp 
                245                 250                 255     


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys 
            260                 265                 270         


Gly Asp Thr Cys Glu Pro Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser 
        275                 280                 285             


Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys 
    290                 295                 300                 


Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro 
305                 310                 315                 320 


Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln 
                325                 330                 335     


Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser 
            340                 345                 350         


Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu 
        355                 360                 365             


Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser 
    370                 375                 380                 


Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val 
385                 390                 395                 400 


Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu 
                405                 410                 415     


Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala 
            420                 425                 430         


Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly 
        435                 440                 445             


Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln 
    450                 455                 460                 


Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr 
465                 470                 475                 480 


Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys 
                485                 490                 495     


Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val 
            500                 505                 510         


Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro 
        515                 520                 525             


Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Gly Lys Met Phe Glu 
    530                 535                 540                 


Ala Thr Ala Val Ser Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val 
545                 550                 555                 560 


Val Ala Val Ala Gly Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe 
                565                 570                 575     


Ile Ile Gly Arg Arg His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly 
            580                 585                 590         


Asp Glu Glu Leu Tyr Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr 
        595                 600                 605             


Ile Asp Pro Glu Thr Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe 
    610                 615                 620                 


Ala Lys Glu Leu Asp Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly 
625                 630                 635                 640 


Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly 
                645                 650                 655     


Lys Arg Asp Val Ala Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr 
            660                 665                 670         


Glu Lys Gln Arg Arg Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln 
        675                 680                 685             


Phe Asp His Pro Asn Val Val His Leu Glu Gly Val Val Thr Arg Gly 
    690                 695                 700                 


Lys Pro Val Met Ile Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp 
705                 710                 715                 720 


Ala Phe Leu Arg Lys His Asp Gly Gln Phe Thr Val Ile Gln Leu Val 
                725                 730                 735     


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met 
            740                 745                 750         


Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser 
        755                 760                 765             


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu 
    770                 775                 780                 


Asp Asp Pro Glu Ala Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val 
785                 790                 795                 800 


Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala 
                805                 810                 815     


Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr 
            820                 825                 830         


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala 
        835                 840                 845             


Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly 
    850                 855                 860                 


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg 
865                 870                 875                 880 


Pro Lys Phe Glu Gln Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn 
                885                 890                 895     


Pro Asn Ser Leu Lys Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser 
            900                 905                 910         


Pro Leu Leu Asp Gln Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val 
        915                 920                 925             


Gly Glu Trp Leu Gln Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe 
    930                 935                 940                 


Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile 
945                 950                 955                 960 


Glu Asp Val Met Ser Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys 
                965                 970                 975     


Ile Met Ser Ser Ile Gln Thr Met Arg Ala Gln Met Leu His Leu His 
            980                 985                 990         


Gly Thr Gly Ile Gln Val 
        995             


<210>  95
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    210                 215                 220                 


Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His 
225                 230                 235                 240 


Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys 
                245                 250                 255     


Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp 
            260                 265                 270         


Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu 
        275                 280                 285             


Lys Gln Asn Thr Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe 
    290                 295                 300                 


Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser 
305                 310                 315                 320 


Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu 
                325                 330                 335     


Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe 
            340                 345                 350         


His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser 
        355                 360                 365             


Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala 
    370                 375                 380                 


His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile 
385                 390                 395                 400 


Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu 
                405                 410                 415     


Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr 
            420                 425                 430         


Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg 
        435                 440                 445             


Tyr Met Ala Pro Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val 
    450                 455                 460                 


Glu Ser Phe Lys Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp 
465                 470                 475                 480 


Glu Met Thr Ser Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu 
                485                 490                 495     


Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met 
            500                 505                 510         


Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe 
        515                 520                 525             


Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu 
    530                 535                 540                 


Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala 
545                 550                 555                 560 


Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser 
                565                 570                 575     


Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys 
            580                 585                 590         


<210>  96
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  97
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 548: pLenti 1 CEA TCR TRAV8-1*01 118P & 119T with murine 
       constant region

<400>  97
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa cctcaggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccag acattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

acggttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgtcagtgat gggtctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct gggactgggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga tctccggaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtccactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  98
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 549: pLenti 1 CEA TCR TRAV8-1*01 118P & 119T TRBV26*01 L117T 
       with murine constant region

<400>  98
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa cctcaggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccag acattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

acggttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgtcagtgat gggtctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct ggggacaggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga tctccggaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtccactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  99
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 550: pLenti 1 CEA TCR TRAV8-1*01 118P & 119T with murine 
       constant region

<400>  99
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa cctcaggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccaa atattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

tgcgttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgctggtgat cgttctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct gggactgggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga cctgcgcaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtgcactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  100
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 551: pLenti 1 CEA TCR TRAV8-1*01 L110F 118P & 119T with 
       murine constant region

<400>  100
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca cctcaggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccag acattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

acggttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgtcagtgat gggtctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct gggactgggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga tctccggaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtccactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  101
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 552: pLenti 1 CEA TCR TRAV8-1*01 S112T 118P & 119T with 
       murine constant region

<400>  101
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa ccaccggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccag acattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

acggttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgtcagtgat gggtctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct gggactgggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga tctccggaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtccactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  102
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 553: pLenti 1 CEA TCR TRAV8-1*01 L110F S112T 118P & 119T with 
       murine constant region

<400>  102
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca ccaccggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccag acattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

acggttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgtcagtgat gggtctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct gggactgggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga tctccggaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtccactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  103
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 554: pLenti 1 CEA TCR TRAV8-1*01 L110F 118P & 119T TRBV26*01 L117T 
       with murine constant region

<400>  103
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca cctcaggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccag acattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

acggttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgtcagtgat gggtctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct ggggacaggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga tctccggaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtccactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  104
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 555: pLenti 1 CEA TCR TRAV8-1*01 S112T 118P & 119T TRBV26*01 L117T 
       with murine constant region

<400>  104
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa ccaccggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccag acattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

acggttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgtcagtgat gggtctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct ggggacaggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga tctccggaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtccactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  105
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 556: pLenti 1 CEA TCR TRAV8-1*01 L110F S112T 118P & 119T TRBV26*01 
       L117T with murine constant region

<400>  105
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca ccaccggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccag acattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

acggttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgtcagtgat gggtctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct ggggacaggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga tctccggaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtccactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  106
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 557: pLenti 1 CEA TCR TRAV8-1*01 L110F 118P & 119T with murine 
       constant region

<400>  106
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca cctcaggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccaa atattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

tgcgttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgctggtgat cgttctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct gggactgggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga cctgcgcaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtgcactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  107
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 558: pLenti 1 CEA TCR TRAV8-1*01 S112T 118P & 119T with murine 
       constant region

<400>  107
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa ccaccggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccaa atattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

tgcgttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgctggtgat cgttctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct gggactgggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga cctgcgcaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtgcactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  108
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 559: pLenti 1 CEA TCR TRAV8-1*01 L110F S112T 118P & 119T with 
       murine constant region

<400>  108
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca ccaccggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccaa atattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

tgcgttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgctggtgat cgttctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct gggactgggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga cctgcgcaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtgcactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  109
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 560: pLenti 1 CEA TCR TRAV8-1*01 118P & 119T TRBV26*01 L117T 
       with murine constant region

<400>  109
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa cctcaggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccaa atattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

tgcgttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgctggtgat cgttctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct ggggacaggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga cctgcgcaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtgcactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  110
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 561: pLenti 1 CEA TCR TRAV8-1*01 L110F 118P & 119T TRBV26*01 
       L117T with murine constant region

<400>  110
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca cctcaggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccaa atattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

tgcgttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgctggtgat cgttctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct ggggacaggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga cctgcgcaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtgcactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  111
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 562: pLenti 1 CEA TCR TRAV8-1*01 S112T 118P & 119T TRBV26*01 
       L117T with murine constant region

<400>  111
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa ccaccggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccaa atattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

tgcgttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgctggtgat cgttctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct ggggacaggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga cctgcgcaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtgcactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  112
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 563: pLenti 1 CEA TCR TRAV8-1*01 L110F S112T 118P & 119T TRBV26*01 
       L117T with murine constant region

<400>  112
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca ccaccggagg aaactacaaa      360

cctacgtttg ggaaagggac cagcctcgtg gttcatccaa atattcagaa ccccgaacca      420

gccgtatatc agttgaagga cccaagatct caggatagta cactctgttt gtttacggac      480

tttgactcac aaatcaacgt cccgaagact atggaaagtg gtacgttcat cacagataag      540

tgcgttctgg acatgaaggc tatggactca aagagcaacg gggcaattgc ttggtccaac      600

cagacaagct ttacctgtca ggacattttt aaggagacta atgctactta tccctccagc      660

gacgttccgt gtgatgcgac tcttaccgag aagtcttttg agaccgatat gaatctcaac      720

ttccagaatc tgctggtgat cgttctgcgg atcctgcttc tgaaggttgc aggattcaat      780

cttcttatga ctctccggct ctggtcttca ggttctggcg cgacgaattt tagtttgctt      840

aagcaagccg gagatgtgga ggaaaatcct ggaccgatgg ctacaaggct cctctgttac      900

acagtacttt gtctcctggg tgcaagaatt ttgaactcaa aagtcattca gactccaaga      960

tatctggtga aagggcaagg acaaaaagca aagatgaggt gtatccctga aaagggacat     1020

ccagttgtat tctggtatca acaaaataag aacaatgagt ttaaattttt gattaacttt     1080

cagaatcaag aagttcttca gcaaatagac atgactgaaa aacgattctc tgctgagtgt     1140

ccttcaaact caccttgcag cctagaaatt cagtcctctg aggcaggaga ctcagcactg     1200

tacctctgtg ccagcagtct ggggacaggg gactatgaac agtacttcgg tcccggcacc     1260

aggctcacgg ttttagagga cctgcgcaac gtcaccccac caaaggtcag tttgtttgag     1320

ccatcaaagg cggagatcgc caacaaacag aaagctacgc tcgtgtgttt ggctcggggc     1380

ttcttcccag accacgtaga actttcctgg tgggtcaatg gaaaggaggt tcattccgga     1440

gtgtgcactg atccccaagc gtacaaggaa tccaactata gctactgtct ctcatctcgg     1500

ctccgggtga gtgcgacatt ctggcataat cctcggaacc actttcgatg ccaagtgcag     1560

tttcatgggt tgagcgagga agacaagtgg cccgagggca gtcctaaacc agtcactcaa     1620

aacataagcg ccgaggcatg gggtagagcc gattgtggga ttactagcgc ttcataccaa     1680

caaggggtat tgagcgctac aattctttac gaaattctcc tcggcaaggc gacgctctac     1740

gccgtactgg tgtctactct cgtggttatg gcaatggtga aacggaaaaa cagctaatag     1800


<210>  113
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 532: pLenti 1 CEA TCR TRAV8-1*01 TRBV26*01 with regular murine 
       constant region

<400>  113
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa cctcaggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccagacattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagacggtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgtcag tgatgggtct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctgggact gggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggatctccg gaacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtcc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  114
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 533: pLenti 1 CEA TCR TRAV8-1*01 TRBV26*01 L117T with regular 
       murine constant region

<400>  114
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa cctcaggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccagacattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagacggtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgtcag tgatgggtct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctggggac aggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggatctccg gaacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtcc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  115
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 534: pLenti 1 CEA TCR TRAV8-1*01 TRBV26*01 murine constant 
       region (no PT)

<400>  115
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa cctcaggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccaaatattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagtgcgtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgctgg tgatcgttct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctgggact gggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggacctgcg caacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtgc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  116
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 535: pLenti 1 CEA TCR TRAV8-1*01 L110F TRBV26*01 with regular 
       murine constant region

<400>  116
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca cctcaggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccagacattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagacggtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgtcag tgatgggtct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctgggact gggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggatctccg gaacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtcc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  117
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 536: pLenti 1 CEA TCR TRAV8-1*01 S112T  TRBV26*01 with regular 
       murine constant region

<400>  117
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa ccaccggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccagacattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagacggtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgtcag tgatgggtct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctgggact gggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggatctccg gaacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtcc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  118
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 537: pLenti 1 CEA TCR TRAV8-1*01 L110F & S112T TRBV26*01 with 
       regular murine constant region

<400>  118
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca ccaccggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccagacattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagacggtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgtcag tgatgggtct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctgggact gggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggatctccg gaacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtcc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  119
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 538: pLenti 1 CEA TCR TRAV8-1*01 L110F TRBV26*01 L117T with 
       regular murine constant region

<400>  119
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca cctcaggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccagacattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagacggtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgtcag tgatgggtct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctggggac aggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggatctccg gaacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtcc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  120
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 539: pLenti 1 CEA TCR TRAV8-1*01 S112T TRBV26*01 L117T with 
       regular murine constant region

<400>  120
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa ccaccggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccagacattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagacggtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgtcag tgatgggtct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctggggac aggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggatctccg gaacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtcc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  121
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 540: pLenti 1 CEA TCR TRAV8-1*01 L110F & S112T TRBV26*01 L117T 
       with regular murine constant region

<400>  121
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca ccaccggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccagacattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagacggtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgtcag tgatgggtct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctggggac aggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggatctccg gaacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtcc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  122
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 541: pLenti 1 CEA TCR TRAV8-1*01 L110F TRBV26*01 with murine 
       constant region

<400>  122
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca cctcaggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccaaatattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagtgcgtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgctgg tgatcgttct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctgggact gggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggacctgcg caacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtgc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  123
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 542: pLenti 1 CEA TCR TRAV8-1*01 S112T TRBV26*01 with murine 
       constant region

<400>  123
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa ccaccggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccaaatattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagtgcgtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgctgg tgatcgttct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctgggact gggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggacctgcg caacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtgc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  124
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 543: pLenti 1 CEA TCR TRAV8-1*01 L110F & S112T TRBV26*01 with 
       murine constant region

<400>  124
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca ccaccggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccaaatattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagtgcgtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgctgg tgatcgttct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctgggact gggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggacctgcg caacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtgc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  125
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 544: pLenti 1 CEA TCR  TRAV8-1*01 TRBV26*01 L117T with murine 
       constant region

<400>  125
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa cctcaggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccaaatattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagtgcgtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgctgg tgatcgttct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctggggac aggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggacctgcg caacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtgc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  126
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 545: pLenti 1 CEA TCR TRAV8-1*01 L110F TRBV26*01 L117T with 
       murine constant region

<400>  126
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca cctcaggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccaaatattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagtgcgtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgctgg tgatcgttct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctggggac aggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggacctgcg caacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtgc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  127
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 546: pLenti 1 CEA TCR TRAV8-1*01 S112T TRBV26*01 L117T with 
       murine constant region

<400>  127
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatctaa ccaccggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccaaatattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagtgcgtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgctgg tgatcgttct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctggggac aggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggacctgcg caacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtgc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  128
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CT 547: pLenti 1 CEA TCR TRAV8-1*01 L110F & S112T TRBV26*01 L117T 
       with murine constant region

<400>  128
atgcacagcc tcctggggtt gttgatggtg tcactgtggc tgcaactgac aagggtgaat       60

agtcaactag cagaagagaa tccgtgggcc ctgagcgtcc acgagggtga aagtgtcacg      120

gtgaattgta gttacaagac atccataact gccctacagt ggtacagaca gaagtcaggc      180

gaaggccctg cccagctaat cttaatacgt tcaaatgaga gagagaagcg caatggaaga      240

ctcagagcca cccttgacac ctccagccag agcagctcct tgtccatcac tgctactcgg      300

tgtgaagaca ccgctgtgta cttctgtgct actgatttca ccaccggagg aaactacaaa      360

tttgggaaag ggaccagcct cgtggttcat ccaaatattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagtgcgtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgctgg tgatcgttct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaggttct ggcgcgacga attttagttt gcttaagcaa      840

gccggagatg tggaggaaaa tcctggaccg atggctacaa ggctcctctg ttacacagta      900

ctttgtctcc tgggtgcaag aattttgaac tcaaaagtca ttcagactcc aagatatctg      960

gtgaaagggc aaggacaaaa agcaaagatg aggtgtatcc ctgaaaaggg acatccagtt     1020

gtattctggt atcaacaaaa taagaacaat gagtttaaat ttttgattaa ctttcagaat     1080

caagaagttc ttcagcaaat agacatgact gaaaaacgat tctctgctga gtgtccttca     1140

aactcacctt gcagcctaga aattcagtcc tctgaggcag gagactcagc actgtacctc     1200

tgtgccagca gtctggggac aggggactat gaacagtact tcggtcccgg caccaggctc     1260

acggttttag aggacctgcg caacgtcacc ccaccaaagg tcagtttgtt tgagccatca     1320

aaggcggaga tcgccaacaa acagaaagct acgctcgtgt gtttggctcg gggcttcttc     1380

ccagaccacg tagaactttc ctggtgggtc aatggaaagg aggttcattc cggagtgtgc     1440

actgatcccc aagcgtacaa ggaatccaac tatagctact gtctctcatc tcggctccgg     1500

gtgagtgcga cattctggca taatcctcgg aaccactttc gatgccaagt gcagtttcat     1560

gggttgagcg aggaagacaa gtggcccgag ggcagtccta aaccagtcac tcaaaacata     1620

agcgccgagg catggggtag agccgattgt gggattacta gcgcttcata ccaacaaggg     1680

gtattgagcg ctacaattct ttacgaaatt ctcctcggca aggcgacgct ctacgccgta     1740

ctggtgtcta ctctcgtggt tatggcaatg gtgaaacgga aaaacagcta atag           1794


<210>  129
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CAR with ScFv; CT 618

<400>  129
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtcagg tgcagctggt gcaatctggg tctgagttga agaagcctgg ggcctcagtg      120

aaggtttcct gcaaggcttc tggatacacc ttcactgagt ttggaatgaa ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggataa acaccaaaac tggagaggca      240

acatatgttg aagagtttaa gggacggttt gtcttctcct tggacacctc tgtcagcacg      300

gcatatctgc agatcagcag cctaaaggct gaagacactg ccgtgtatta ctgtgcgaga      360

tgggacttcg cttattacgt ggaggctatg gactactggg gccaagggac cacggtcacc      420

gtctcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      480

gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc      540

atcacttgca aggccagtca gaatgtgggt actaatgttg cctggtatca gcagaaacca      600

gggaaagcac ctaagctcct gatctattcg gcatcctacc gctacagtgg agtcccatca      660

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      720

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      780

cagggcacca agctcgagat caagacaacg acgccagctc cccgcccgcc aacccctgca      840

cctacgattg catcacaacc gctgtccctg cggcctgaag cttgtcgccc agccgcaggt      900

ggcgccgtac atacacgggg gctggatttt gcctgtgatt tctgggtgct ggtcgttgtg      960

ggcggcgtgc tggcctgcta cagcctgctg gtgacagtgg ccttcatcat cttttgggtg     1020

aggagcaagc ggagtcgact gctgcacagc gactacatga acatgacccc ccggaggcct     1080

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg     1140

agcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gaggccagta     1200

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1260

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     1320

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1380

cgtagaggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1440

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1500

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggactcag tacagccacc     1560

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctag                  1608


<210>  130
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CAR with ScFv; CT 619

<400>  130
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtcagg tgcagctggt gcagtctggc gccgaagtga agaaacctgg agctagtgtg      120

aaggtgtcct gcaaggccag cggctacacc ttcaccgagt tcggcatgaa ctgggtccga      180

caggctccag gccagggcct cgaatggatg ggctggatca acaccaagac cggcgaggcc      240

acctacgtgg aagagttcaa gggcagagtg accttcacca cggacaccag caccagcacc      300

gcctacatgg aactgcggag cctgagaagc gacgacaccg ccgtgtacta ctgcgccaga      360

tgggacttcg cttattacgt ggaagccatg gactactggg gccagggcac caccgtgacc      420

gtgtctagcg gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      480

gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc      540

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      600

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      660

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      720

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      780

cagggcacca agctcgagat caagcgtacg acaacgacgc cagctccccg cccgccaacc      840

cctgcaccta cgattgcatc acaaccgctg tccctgcggc ctgaagcttg tcgcccagcc      900

gcaggtggcg ccgtacatac acgggggctg gattttgcct gtgatttctg ggtgctggtc      960

gttgtgggcg gcgtgctggc ctgctacagc ctgctggtga cagtggcctt catcatcttt     1020

tgggtgagga gcaagcggag tcgactgctg cacagcgact acatgaacat gaccccccgg     1080

aggcctggcc ccacccggaa gcactaccag ccctacgccc ctcccaggga tttcgccgcc     1140

taccggagca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgagg     1200

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1260

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     1320

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1380

gacaagcgta gaggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1440

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1500

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg actcagtaca     1560

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctag           1614


<210>  131
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CAR with ScFv; CT 620

<400>  131
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtcagg tgcagctggt gcaatctggg tctgagttga agaagcctgg ggcctcagtg      120

aaggtttcct gcaaggcttc tggatacacc ttcactgagt ttggaatgaa ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggataa acaccaaaac tggagaggca      240

acatatgttg aagagtttaa gggacggttt gtcttctcct tggacacctc tgtcagcacg      300

gcatatctgc agatcagcag cctaaaggct gaagacactg ccgtgtatta ctgtgcgaga      360

tgggactttg ctcattactt tcagactatg gactactggg gccaagggac cacggtcacc      420

gtctcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      480

gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc      540

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      600

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      660

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      720

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      780

cagggcacca agctcgagat caagcgtaca acgacgccag ctccccgccc gccaacccct      840

gcacctacga ttgcatcaca accgctgtcc ctgcggcctg aagcttgtcg cccagccgca      900

ggtggcgccg tacatacacg ggggctggat tttgcctgtg atttctgggt gctggtcgtt      960

gtgggcggcg tgctggcctg ctacagcctg ctggtgacag tggccttcat catcttttgg     1020

gtgaggagca agcggagtcg actgctgcac agcgactaca tgaacatgac cccccggagg     1080

cctggcccca cccggaagca ctaccagccc tacgcccctc ccagggattt cgccgcctac     1140

cggagcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgaggcca     1200

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1260

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     1320

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1380

aagcgtagag gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     1440

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1500

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggact cagtacagcc     1560

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta g              1611


<210>  132
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; MFE23M

<400>  132

Cys Ala Gly Gly Thr Cys Cys Ala Gly Cys Thr Gly Cys Ala Gly Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Gly Gly Cys Ala Gly Ala Gly Cys Thr 
            20                  25                  30          


Thr Gly Thr Gly Ala Gly Gly Thr Cys Ala Gly Gly Gly Ala Cys Cys 
        35                  40                  45              


Thr Cys Ala Gly Thr Cys Ala Ala Gly Thr Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Cys Ala Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr Thr 
65                  70                  75                  80  


Cys Ala Ala Cys Ala Thr Thr Ala Ala Ala Gly Ala Cys Thr Cys Cys 
                85                  90                  95      


Thr Ala Thr Ala Thr Gly Cys Ala Cys Thr Gly Gly Thr Thr Gly Ala 
            100                 105                 110         


Gly Gly Cys Ala Gly Gly Gly Gly Cys Cys Thr Gly Ala Ala Cys Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Ala Thr Gly Gly Ala Thr Thr Gly Ala Thr Cys Cys Thr Gly 
145                 150                 155                 160 


Ala Gly Ala Ala Thr Gly Gly Thr Gly Ala Thr Ala Cys Thr Gly Ala 
                165                 170                 175     


Ala Thr Ala Thr Gly Cys Cys Cys Cys Gly Ala Ala Gly Thr Thr Cys 
            180                 185                 190         


Cys Ala Gly Gly Gly Cys Ala Ala Gly Gly Cys Cys Ala Cys Thr Thr 
        195                 200                 205             


Thr Thr Ala Cys Thr Ala Cys Ala Gly Ala Cys Ala Cys Ala Thr Cys 
    210                 215                 220                 


Cys Thr Cys Cys Ala Ala Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Cys Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Thr Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Ala Ala Thr Gly Ala Ala Gly Gly Gly Ala Cys Ala Cys Cys Gly Ala 
    290                 295                 300                 


Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Cys Thr Ala Thr Thr Thr 
305                 310                 315                 320 


Thr Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala 
                325                 330                 335     


Gly Gly Ala Ala Cys Cys Ala Cys Ala Gly Thr Cys Ala Cys Cys Gly 
            340                 345                 350         


Thr Gly Thr Cys Cys Thr Cys Ala Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Thr Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Gly Gly Gly Ala 
    370                 375                 380                 


Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Gly 
385                 390                 395                 400 


Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Cys Gly Ala Gly Ala Ala 
                405                 410                 415     


Cys Gly Thr Thr Cys Thr Cys Ala Cys Cys Cys Ala Gly Thr Cys Thr 
            420                 425                 430         


Cys Cys Ala Gly Cys Ala Ala Thr Cys Ala Thr Gly Thr Cys Thr Gly 
        435                 440                 445             


Cys Ala Thr Cys Thr Cys Cys Ala Gly Gly Gly Gly Ala Gly Ala Ala 
    450                 455                 460                 


Gly Gly Thr Cys Ala Cys Cys Ala Thr Ala Ala Cys Cys Thr Gly Cys 
465                 470                 475                 480 


Ala Gly Thr Gly Cys Cys Ala Gly Cys Thr Cys Ala Ala Gly Thr Gly 
                485                 490                 495     


Thr Ala Ala Gly Thr Thr Ala Cys Ala Thr Gly Cys Ala Cys Thr Gly 
            500                 505                 510         


Gly Thr Thr Cys Cys Ala Gly Cys Ala Gly Ala Ala Gly Cys Cys Ala 
        515                 520                 525             


Gly Gly Cys Ala Cys Thr Thr Cys Thr Cys Cys Cys Ala Ala Ala Cys 
    530                 535                 540                 


Thr Cys Thr Gly Gly Ala Thr Thr Thr Ala Thr Ala Gly Cys Ala Cys 
545                 550                 555                 560 


Ala Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly Cys Thr Thr Cys Thr 
                565                 570                 575     


Gly Gly Ala Gly Thr Cys Cys Cys Thr Gly Cys Thr Cys Gly Cys Thr 
            580                 585                 590         


Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr Gly Gly Ala Thr Cys 
        595                 600                 605             


Thr Gly Gly Gly Ala Cys Cys Thr Cys Thr Thr Ala Cys Thr Cys Thr 
    610                 615                 620                 


Cys Thr Cys Ala Cys Ala Ala Thr Cys Ala Gly Cys Cys Gly Ala Ala 
625                 630                 635                 640 


Thr Gly Gly Ala Gly Gly Cys Thr Gly Ala Ala Gly Ala Thr Gly Cys 
                645                 650                 655     


Thr Gly Cys Cys Ala Cys Thr Thr Ala Thr Thr Ala Cys Thr Gly Cys 
            660                 665                 670         


Cys Ala Gly Cys Ala Ala Ala Gly Gly Ala Gly Thr Ala Gly Thr Thr 
        675                 680                 685             


Ala Cys Cys Cys Gly Cys Thr Cys Ala Cys Gly Thr Thr Cys Gly Gly 
    690                 695                 700                 


Thr Gly Cys Thr Gly Gly Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly 
705                 710                 715                 720 


Gly Ala Gly Cys Thr Gly Ala Ala Ala 
                725                 


<210>  133
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; MFE23H

<400>  133

Cys Ala Gly Gly Thr Cys Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Gly Gly Cys Ala Gly Ala Gly Gly Thr 
            20                  25                  30          


Gly Ala Ala Gly Ala Ala Ala Cys Cys Ala Gly Gly Gly Gly Cys Cys 
        35                  40                  45              


Thr Cys Ala Gly Thr Cys Ala Ala Gly Gly Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Ala Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr Thr 
65                  70                  75                  80  


Cys Ala Ala Cys Ala Thr Thr Ala Ala Ala Gly Ala Cys Thr Cys Cys 
                85                  90                  95      


Thr Ala Thr Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Ala 
            100                 105                 110         


Gly Gly Cys Ala Gly Gly Cys Gly Cys Cys Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala Thr Gly 
    130                 135                 140                 


Gly Gly Ala Thr Gly Gly Ala Thr Thr Gly Ala Thr Cys Cys Thr Gly 
145                 150                 155                 160 


Ala Gly Ala Ala Thr Gly Gly Thr Gly Ala Thr Ala Cys Thr Gly Ala 
                165                 170                 175     


Ala Thr Ala Thr Gly Cys Cys Cys Cys Gly Ala Ala Gly Thr Thr Cys 
            180                 185                 190         


Cys Ala Gly Gly Gly Cys Ala Gly Gly Gly Thr Cys Ala Cys Thr Ala 
        195                 200                 205             


Thr Gly Ala Cys Thr Ala Cys Ala Gly Ala Cys Ala Cys Ala Thr Cys 
    210                 215                 220                 


Cys Ala Cys Cys Thr Cys Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Ala Thr Gly Gly Ala Gly Cys Thr Cys Ala Gly Gly Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Gly Ala Thr Cys Thr Gly Ala Cys Gly Ala Cys Ala Cys 
            260                 265                 270         


Thr Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Ala Ala Thr Gly Ala Ala Gly Gly Gly Ala Cys Ala Cys Cys Gly Ala 
    290                 295                 300                 


Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Cys Thr Ala Thr Thr Thr 
305                 310                 315                 320 


Thr Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala 
                325                 330                 335     


Gly Gly Ala Ala Cys Cys Ala Cys Ala Gly Thr Cys Ala Cys Cys Gly 
            340                 345                 350         


Thr Gly Thr Cys Cys Thr Cys Ala Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Thr Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Gly Gly Gly Ala 
    370                 375                 380                 


Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Gly 
385                 390                 395                 400 


Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Cys Gly Ala Gly Ala Thr 
                405                 410                 415     


Cys Gly Thr Thr Cys Thr Cys Ala Cys Cys Cys Ala Gly Thr Cys Thr 
            420                 425                 430         


Cys Cys Ala Gly Cys Ala Ala Cys Cys Thr Thr Gly Thr Cys Thr Cys 
        435                 440                 445             


Thr Gly Thr Cys Thr Cys Cys Ala Gly Gly Gly Gly Ala Gly Ala Gly 
    450                 455                 460                 


Gly Gly Cys Cys Ala Cys Cys Cys Thr Ala Ala Gly Cys Thr Gly Cys 
465                 470                 475                 480 


Ala Gly Thr Gly Cys Cys Ala Gly Cys Thr Cys Ala Ala Gly Thr Gly 
                485                 490                 495     


Thr Ala Ala Gly Thr Thr Ala Cys Ala Thr Gly Cys Ala Cys Thr Gly 
            500                 505                 510         


Gly Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala Ala Gly Cys Cys Ala 
        515                 520                 525             


Gly Gly Cys Cys Thr Thr Gly Cys Thr Cys Cys Cys Ala Gly Ala Cys 
    530                 535                 540                 


Thr Cys Cys Thr Gly Ala Thr Thr Thr Ala Thr Ala Gly Cys Ala Cys 
545                 550                 555                 560 


Ala Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly Cys Thr Thr Cys Thr 
                565                 570                 575     


Gly Gly Ala Ala Thr Cys Cys Cys Thr Gly Ala Thr Cys Gly Cys Thr 
            580                 585                 590         


Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr Gly Gly Ala Thr Cys 
        595                 600                 605             


Thr Gly Gly Gly Ala Cys Cys Gly Ala Thr Thr Thr Cys Ala Cys Thr 
    610                 615                 620                 


Cys Thr Cys Ala Cys Ala Ala Thr Cys Ala Gly Cys Cys Gly Ala Cys 
625                 630                 635                 640 


Thr Gly Gly Ala Gly Cys Cys Thr Gly Ala Ala Gly Ala Thr Thr Thr 
                645                 650                 655     


Cys Gly Cys Cys Gly Thr Thr Thr Ala Thr Thr Ala Cys Thr Gly Cys 
            660                 665                 670         


Cys Ala Gly Cys Ala Ala Ala Gly Gly Ala Gly Thr Ala Gly Thr Thr 
        675                 680                 685             


Ala Cys Cys Cys Gly Cys Thr Cys Ala Cys Gly Thr Thr Cys Gly Gly 
    690                 695                 700                 


Thr Cys Ala Gly Gly Gly Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly 
705                 710                 715                 720 


Gly Ala Gly Ala Thr Cys Ala Ala Ala 
                725                 


<210>  134
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; E8

<400>  134

Gly Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Cys Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr 
            20                  25                  30          


Gly Gly Thr Ala Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr 
    50                  55                  60                  


Gly Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Thr Thr 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Thr Ala Gly Cys Ala Gly Cys Gly Ala Thr 
                85                  90                  95      


Gly Cys Cys Ala Thr Gly Ala Gly Cys Thr Gly Gly Gly Thr Cys Cys 
            100                 105                 110         


Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala 
        115                 120                 125             


Gly Gly Gly Gly Cys Thr Gly Gly Ala Gly Thr Gly Gly Gly Thr Cys 
    130                 135                 140                 


Thr Cys Ala Gly Cys Thr Ala Thr Thr Ala Gly Thr Gly Gly Thr Ala 
145                 150                 155                 160 


Gly Thr Gly Gly Thr Gly Gly Thr Ala Gly Cys Ala Cys Ala Thr Ala 
                165                 170                 175     


Cys Thr Ala Cys Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly 
            180                 185                 190         


Ala Ala Gly Gly Gly Cys Cys Gly Gly Thr Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Thr Cys Cys Ala Gly Ala Gly Ala Cys Ala Ala Thr Thr Cys 
    210                 215                 220                 


Cys Ala Ala Gly Ala Ala Cys Ala Cys Gly Cys Thr Gly Thr Ala Thr 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Gly Ala Gly Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Ala Ala Ala Gly Thr Cys Thr Ala Ala Thr Gly Ala Gly Thr 
    290                 295                 300                 


Thr Thr Cys Thr Thr Thr Thr Thr Gly Ala Cys Thr Ala Cys Thr Gly 
305                 310                 315                 320 


Gly Gly Gly Cys Cys Ala Ala Gly Gly Thr Ala Cys Cys Cys Thr Gly 
                325                 330                 335     


Gly Thr Cys Ala Cys Cys Gly Thr Gly Thr Cys Gly Ala Gly Thr Gly 
            340                 345                 350         


Gly Cys Gly Gly Ala Gly Gly Thr Gly Gly Ala Ala Gly Cys Gly Gly 
        355                 360                 365             


Ala Gly Gly Gly Gly Gly Ala Gly Gly Ala Thr Cys Thr Gly Gly Cys 
    370                 375                 380                 


Gly Gly Cys Gly Gly Ala Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly 
385                 390                 395                 400 


Gly Cys Thr Cys Thr Thr Cys Thr Gly Ala Gly Cys Thr Gly Ala Cys 
                405                 410                 415     


Thr Cys Ala Gly Gly Ala Cys Cys Cys Thr Gly Cys Thr Gly Thr Gly 
            420                 425                 430         


Thr Cys Thr Gly Thr Gly Gly Cys Cys Thr Thr Gly Gly Gly Ala Cys 
        435                 440                 445             


Ala Gly Ala Cys Ala Gly Thr Cys Ala Gly Gly Ala Thr Cys Ala Cys 
    450                 455                 460                 


Ala Thr Gly Cys Cys Ala Ala Gly Gly Ala Gly Ala Cys Ala Gly Cys 
465                 470                 475                 480 


Cys Thr Cys Ala Gly Ala Ala Gly Cys Thr Cys Thr Thr Ala Thr Gly 
                485                 490                 495     


Cys Ala Ala Gly Cys Thr Gly Gly Thr Ala Cys Cys Gly Gly Cys Ala 
            500                 505                 510         


Gly Ala Gly Gly Cys Cys Ala Gly Gly Ala Cys Ala Gly Gly Cys Cys 
        515                 520                 525             


Cys Cys Thr Gly Thr Ala Cys Thr Thr Gly Thr Cys Ala Thr Cys Thr 
    530                 535                 540                 


Ala Thr Gly Gly Thr Ala Ala Ala Ala Ala Cys Ala Ala Cys Cys Gly 
545                 550                 555                 560 


Gly Cys Cys Cys Thr Cys Ala Gly Gly Gly Ala Thr Cys Cys Cys Ala 
                565                 570                 575     


Gly Ala Cys Cys Gly Ala Thr Thr Cys Thr Cys Thr Gly Gly Cys Thr 
            580                 585                 590         


Cys Cys Ala Gly Cys Thr Cys Ala Gly Gly Ala Ala Ala Cys Ala Cys 
        595                 600                 605             


Ala Gly Cys Thr Thr Cys Cys Thr Thr Gly Ala Cys Cys Ala Thr Cys 
    610                 615                 620                 


Ala Cys Thr Gly Gly Gly Gly Cys Thr Cys Ala Gly Gly Cys Gly Gly 
625                 630                 635                 640 


Ala Ala Gly Ala Thr Gly Ala Gly Gly Cys Thr Gly Ala Cys Thr Ala 
                645                 650                 655     


Thr Thr Ala Cys Thr Gly Gly Ala Ala Cys Thr Cys Cys Ala Gly Cys 
            660                 665                 670         


Thr Ala Cys Gly Cys Thr Thr Gly Gly Cys Thr Gly Cys Cys Cys Thr 
        675                 680                 685             


Ala Cys Gly Thr Gly Gly Thr Ala Thr Thr Cys Gly Gly Cys Gly Gly 
    690                 695                 700                 


Ala Gly Gly Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Ala Cys Cys 
705                 710                 715                 720 


Gly Thr Cys Cys Thr Ala Gly Gly Thr 
                725                 


<210>  135
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; SM3E

<400>  135

Cys Ala Gly Gly Thr Cys Cys Ala Gly Cys Thr Gly Gly Ala Gly Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Gly Gly Cys Ala Gly Gly Gly Gly Thr 
            20                  25                  30          


Thr Gly Thr Gly Ala Ala Gly Cys Cys Ala Gly Gly Gly Gly Cys Cys 
        35                  40                  45              


Thr Cys Ala Gly Thr Cys Ala Ala Gly Thr Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Ala Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr Thr 
65                  70                  75                  80  


Cys Ala Ala Cys Ala Thr Thr Ala Ala Ala Gly Ala Cys Thr Cys Cys 
                85                  90                  95      


Thr Ala Thr Ala Thr Gly Cys Ala Cys Thr Gly Gly Thr Thr Gly Ala 
            100                 105                 110         


Gly Gly Cys Ala Gly Gly Gly Gly Cys Cys Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Gly Cys Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Ala Thr Gly Gly Ala Thr Thr Gly Ala Thr Cys Cys Thr Gly 
145                 150                 155                 160 


Ala Gly Ala Ala Thr Gly Gly Thr Gly Ala Thr Ala Cys Thr Gly Ala 
                165                 170                 175     


Ala Thr Ala Thr Gly Cys Cys Cys Cys Gly Ala Ala Gly Thr Thr Cys 
            180                 185                 190         


Cys Ala Gly Gly Gly Cys Ala Ala Gly Gly Cys Cys Ala Cys Thr Thr 
        195                 200                 205             


Thr Thr Ala Cys Thr Ala Cys Ala Gly Ala Cys Ala Cys Ala Thr Cys 
    210                 215                 220                 


Cys Gly Cys Cys Ala Ala Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Gly Gly Gly Cys Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Gly Ala Cys Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Thr Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Ala Ala Thr Gly Ala Ala Gly Gly Gly Ala Cys Ala Cys Cys Gly Ala 
    290                 295                 300                 


Cys Ala Gly Gly Gly Cys Cys Ala Thr Ala Cys Thr Ala Thr Thr Thr 
305                 310                 315                 320 


Thr Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala 
                325                 330                 335     


Gly Gly Ala Ala Cys Cys Cys Thr Ala Gly Thr Cys Ala Cys Cys Gly 
            340                 345                 350         


Thr Gly Thr Cys Cys Thr Cys Ala Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Thr Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Gly Gly Gly Ala 
    370                 375                 380                 


Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Gly 
385                 390                 395                 400 


Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Cys Gly Ala Gly Ala Ala 
                405                 410                 415     


Cys Gly Thr Thr Cys Thr Cys Ala Cys Cys Cys Ala Gly Thr Cys Thr 
            420                 425                 430         


Cys Cys Ala Ala Gly Cys Thr Cys Thr Ala Thr Gly Thr Cys Thr Gly 
        435                 440                 445             


Thr Ala Thr Cys Thr Gly Thr Cys Gly Gly Gly Gly Ala Cys Ala Gly 
    450                 455                 460                 


Gly Gly Thr Cys Ala Ala Cys Ala Thr Cys Gly Cys Cys Thr Gly Cys 
465                 470                 475                 480 


Ala Gly Thr Gly Cys Cys Ala Gly Cys Thr Cys Ala Ala Gly Thr Gly 
                485                 490                 495     


Thr Ala Cys Cys Thr Thr Ala Cys Ala Thr Gly Cys Ala Cys Thr Gly 
            500                 505                 510         


Gly Cys Thr Cys Cys Ala Gly Cys Ala Gly Ala Ala Gly Cys Cys Ala 
        515                 520                 525             


Gly Gly Cys Ala Ala Ala Thr Cys Thr Cys Cys Cys Ala Ala Ala Cys 
    530                 535                 540                 


Thr Cys Cys Thr Gly Ala Thr Thr Thr Ala Thr Cys Thr Cys Ala Cys 
545                 550                 555                 560 


Ala Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly Cys Thr Thr Cys Thr 
                565                 570                 575     


Gly Gly Ala Gly Thr Cys Cys Cys Thr Ala Gly Cys Cys Gly Cys Thr 
            580                 585                 590         


Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr Gly Gly Ala Thr Cys 
        595                 600                 605             


Thr Gly Gly Gly Ala Cys Cys Gly Ala Thr Thr Ala Cys Thr Cys Thr 
    610                 615                 620                 


Cys Thr Cys Ala Cys Ala Ala Thr Cys Ala Gly Cys Thr Cys Ala Gly 
625                 630                 635                 640 


Thr Gly Cys Ala Gly Cys Cys Thr Gly Ala Ala Gly Ala Thr Gly Cys 
                645                 650                 655     


Thr Gly Cys Cys Ala Cys Thr Thr Ala Thr Thr Ala Cys Thr Gly Cys 
            660                 665                 670         


Cys Ala Gly Cys Ala Ala Ala Gly Gly Ala Gly Thr Ala Gly Thr Thr 
        675                 680                 685             


Ala Cys Cys Cys Gly Cys Thr Cys Ala Cys Gly Thr Thr Cys Gly Gly 
    690                 695                 700                 


Thr Gly Gly Thr Gly Gly Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly 
705                 710                 715                 720 


Gly Ala Gly Ala Thr Cys Ala Ala Ala 
                725                 


<210>  136
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; CT618

<400>  136

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys 
1               5                   10                  15      


Ala Ala Thr Cys Thr Gly Gly Gly Thr Cys Thr Gly Ala Gly Thr Thr 
            20                  25                  30          


Gly Ala Ala Gly Ala Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Cys 
        35                  40                  45              


Thr Cys Ala Gly Thr Gly Ala Ala Gly Gly Thr Thr Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys Thr Gly Gly Ala Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Cys Thr Gly Ala Gly Thr Thr Thr 
                85                  90                  95      


Gly Gly Ala Ala Thr Gly Ala Ala Cys Thr Gly Gly Gly Thr Gly Cys 
            100                 105                 110         


Gly Ala Cys Ala Gly Gly Cys Cys Cys Cys Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Ala Gly Gly Gly Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Gly 
    130                 135                 140                 


Gly Gly Ala Thr Gly Gly Ala Thr Ala Ala Ala Cys Ala Cys Cys Ala 
145                 150                 155                 160 


Ala Ala Ala Cys Thr Gly Gly Ala Gly Ala Gly Gly Cys Ala Ala Cys 
                165                 170                 175     


Ala Thr Ala Thr Gly Thr Thr Gly Ala Ala Gly Ala Gly Thr Thr Thr 
            180                 185                 190         


Ala Ala Gly Gly Gly Ala Cys Gly Gly Thr Thr Thr Gly Thr Cys Thr 
        195                 200                 205             


Thr Cys Thr Cys Cys Thr Thr Gly Gly Ala Cys Ala Cys Cys Thr Cys 
    210                 215                 220                 


Thr Gly Thr Cys Ala Gly Cys Ala Cys Gly Gly Cys Ala Thr Ala Thr 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Ala Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Ala Ala Ala Gly Gly Cys Thr Gly Ala Ala Gly Ala Cys Ala Cys 
            260                 265                 270         


Thr Gly Cys Cys Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Gly Ala Gly Ala Thr Gly Gly Gly Ala Cys Thr Thr Cys Gly 
    290                 295                 300                 


Cys Thr Thr Ala Thr Thr Ala Cys Gly Thr Gly Gly Ala Gly Gly Cys 
305                 310                 315                 320 


Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys 
                325                 330                 335     


Cys Ala Ala Gly Gly Gly Ala Cys Cys Ala Cys Gly Gly Thr Cys Ala 
            340                 345                 350         


Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala Gly Gly Cys Gly Gly 
        355                 360                 365             


Ala Gly Gly Thr Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Gly 
    370                 375                 380                 


Gly Gly Ala Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Gly Cys Gly 
385                 390                 395                 400 


Gly Ala Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Cys Gly Ala 
                405                 410                 415     


Thr Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys Ala Gly 
            420                 425                 430         


Thr Cys Thr Cys Cys Ala Thr Cys Cys Thr Cys Cys Cys Thr Gly Thr 
        435                 440                 445             


Cys Thr Gly Cys Ala Thr Cys Thr Gly Thr Gly Gly Gly Ala Gly Ala 
    450                 455                 460                 


Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala Cys Thr 
465                 470                 475                 480 


Thr Gly Cys Ala Ala Gly Gly Cys Cys Ala Gly Thr Cys Ala Gly Ala 
                485                 490                 495     


Ala Thr Gly Thr Gly Gly Gly Thr Ala Cys Thr Ala Ala Thr Gly Thr 
            500                 505                 510         


Thr Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly 
        515                 520                 525             


Ala Ala Ala Cys Cys Ala Gly Gly Gly Ala Ala Ala Gly Cys Ala Cys 
    530                 535                 540                 


Cys Thr Ala Ala Gly Cys Thr Cys Cys Thr Gly Ala Thr Cys Thr Ala 
545                 550                 555                 560 


Thr Thr Cys Gly Gly Cys Ala Thr Cys Cys Thr Ala Cys Cys Gly Cys 
                565                 570                 575     


Thr Ala Cys Ala Gly Thr Gly Gly Ala Gly Thr Cys Cys Cys Ala Thr 
            580                 585                 590         


Cys Ala Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly 
        595                 600                 605             


Thr Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Cys Ala Gly Ala Thr 
    610                 615                 620                 


Thr Thr Cys Ala Cys Thr Cys Thr Cys Ala Cys Cys Ala Thr Cys Ala 
625                 630                 635                 640 


Gly Cys Ala Gly Thr Cys Thr Gly Cys Ala Ala Cys Cys Thr Gly Ala 
                645                 650                 655     


Ala Gly Ala Thr Thr Thr Cys Gly Cys Ala Ala Cys Thr Thr Ala Cys 
            660                 665                 670         


Thr Ala Cys Thr Gly Thr Cys Ala Cys Cys Ala Ala Thr Ala Thr Thr 
        675                 680                 685             


Ala Cys Ala Cys Cys Thr Ala Thr Cys Cys Thr Cys Thr Ala Thr Thr 
    690                 695                 700                 


Cys Ala Cys Gly Thr Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Cys 
705                 710                 715                 720 


Ala Cys Cys Ala Ala Gly Cys Thr Cys Gly Ala Gly Ala Thr Cys Ala 
                725                 730                 735     


Ala Gly 
        


<210>  137
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; CT619

<400>  137

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Cys Gly Cys Cys Gly Ala Ala Gly Thr 
            20                  25                  30          


Gly Ala Ala Gly Ala Ala Ala Cys Cys Thr Gly Gly Ala Gly Cys Thr 
        35                  40                  45              


Ala Gly Thr Gly Thr Gly Ala Ala Gly Gly Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Cys Ala Gly Cys Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Gly Ala Gly Thr Thr Cys 
                85                  90                  95      


Gly Gly Cys Ala Thr Gly Ala Ala Cys Thr Gly Gly Gly Thr Cys Cys 
            100                 105                 110         


Gly Ala Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Cys Cys Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Thr Cys Gly Ala Ala Thr Gly Gly Ala Thr Gly 
    130                 135                 140                 


Gly Gly Cys Thr Gly Gly Ala Thr Cys Ala Ala Cys Ala Cys Cys Ala 
145                 150                 155                 160 


Ala Gly Ala Cys Cys Gly Gly Cys Gly Ala Gly Gly Cys Cys Ala Cys 
                165                 170                 175     


Cys Thr Ala Cys Gly Thr Gly Gly Ala Ala Gly Ala Gly Thr Thr Cys 
            180                 185                 190         


Ala Ala Gly Gly Gly Cys Ala Gly Ala Gly Thr Gly Ala Cys Cys Thr 
        195                 200                 205             


Thr Cys Ala Cys Cys Ala Cys Gly Gly Ala Cys Ala Cys Cys Ala Gly 
    210                 215                 220                 


Cys Ala Cys Cys Ala Gly Cys Ala Cys Cys Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Ala Thr Gly Gly Ala Ala Cys Thr Gly Cys Gly Gly Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Gly Ala Ala Gly Cys Gly Ala Cys Gly Ala Cys Ala Cys 
            260                 265                 270         


Cys Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys 
        275                 280                 285             


Gly Cys Cys Ala Gly Ala Thr Gly Gly Gly Ala Cys Thr Thr Cys Gly 
    290                 295                 300                 


Cys Thr Thr Ala Thr Thr Ala Cys Gly Thr Gly Gly Ala Ala Gly Cys 
305                 310                 315                 320 


Cys Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys 
                325                 330                 335     


Cys Ala Gly Gly Gly Cys Ala Cys Cys Ala Cys Cys Gly Thr Gly Ala 
            340                 345                 350         


Cys Cys Gly Thr Gly Thr Cys Thr Ala Gly Cys Gly Gly Cys Gly Gly 
        355                 360                 365             


Ala Gly Gly Thr Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Gly 
    370                 375                 380                 


Gly Gly Ala Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Gly Cys Gly 
385                 390                 395                 400 


Gly Ala Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Cys Gly Ala 
                405                 410                 415     


Thr Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys Ala Gly 
            420                 425                 430         


Thr Cys Thr Cys Cys Ala Thr Cys Cys Thr Cys Cys Cys Thr Gly Thr 
        435                 440                 445             


Cys Thr Gly Cys Ala Thr Cys Thr Gly Thr Gly Gly Gly Ala Gly Ala 
    450                 455                 460                 


Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala Cys Thr 
465                 470                 475                 480 


Thr Gly Cys Ala Ala Gly Gly Cys Cys Ala Gly Thr Gly Cys Gly Gly 
                485                 490                 495     


Cys Thr Gly Thr Gly Gly Gly Thr Ala Cys Gly Thr Ala Thr Gly Thr 
            500                 505                 510         


Thr Gly Cys Gly Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly 
        515                 520                 525             


Ala Ala Ala Cys Cys Ala Gly Gly Gly Ala Ala Ala Gly Cys Ala Cys 
    530                 535                 540                 


Cys Thr Ala Ala Gly Cys Thr Cys Cys Thr Gly Ala Thr Cys Thr Ala 
545                 550                 555                 560 


Thr Thr Cys Gly Gly Cys Ala Thr Cys Cys Thr Ala Cys Cys Gly Cys 
                565                 570                 575     


Ala Ala Ala Ala Gly Gly Gly Gly Ala Gly Thr Cys Cys Cys Ala Thr 
            580                 585                 590         


Cys Ala Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly 
        595                 600                 605             


Thr Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Cys Ala Gly Ala Thr 
    610                 615                 620                 


Thr Thr Cys Ala Cys Thr Cys Thr Cys Ala Cys Cys Ala Thr Cys Ala 
625                 630                 635                 640 


Gly Cys Ala Gly Thr Cys Thr Gly Cys Ala Ala Cys Cys Thr Gly Ala 
                645                 650                 655     


Ala Gly Ala Thr Thr Thr Cys Gly Cys Ala Ala Cys Thr Thr Ala Cys 
            660                 665                 670         


Thr Ala Cys Thr Gly Thr Cys Ala Cys Cys Ala Ala Thr Ala Thr Thr 
        675                 680                 685             


Ala Cys Ala Cys Cys Thr Ala Thr Cys Cys Thr Cys Thr Ala Thr Thr 
    690                 695                 700                 


Cys Ala Cys Gly Thr Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Cys 
705                 710                 715                 720 


Ala Cys Cys Ala Ala Gly Cys Thr Cys Gly Ala Gly Ala Thr Cys Ala 
                725                 730                 735     


Ala Gly 
        


<210>  138
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ScFv that target CEA; CT620

<400>  138

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys 
1               5                   10                  15      


Ala Ala Thr Cys Thr Gly Gly Gly Thr Cys Thr Gly Ala Gly Thr Thr 
            20                  25                  30          


Gly Ala Ala Gly Ala Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Cys 
        35                  40                  45              


Thr Cys Ala Gly Thr Gly Ala Ala Gly Gly Thr Thr Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys Thr Gly Gly Ala Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Cys Thr Gly Ala Gly Thr Thr Thr 
                85                  90                  95      


Gly Gly Ala Ala Thr Gly Ala Ala Cys Thr Gly Gly Gly Thr Gly Cys 
            100                 105                 110         


Gly Ala Cys Ala Gly Gly Cys Cys Cys Cys Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Ala Gly Gly Gly Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Gly 
    130                 135                 140                 


Gly Gly Ala Thr Gly Gly Ala Thr Ala Ala Ala Cys Ala Cys Cys Ala 
145                 150                 155                 160 


Ala Ala Ala Cys Thr Gly Gly Ala Gly Ala Gly Gly Cys Ala Ala Cys 
                165                 170                 175     


Ala Thr Ala Thr Gly Thr Thr Gly Ala Ala Gly Ala Gly Thr Thr Thr 
            180                 185                 190         


Ala Ala Gly Gly Gly Ala Cys Gly Gly Thr Thr Thr Gly Thr Cys Thr 
        195                 200                 205             


Thr Cys Thr Cys Cys Thr Thr Gly Gly Ala Cys Ala Cys Cys Thr Cys 
    210                 215                 220                 


Thr Gly Thr Cys Ala Gly Cys Ala Cys Gly Gly Cys Ala Thr Ala Thr 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Ala Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Ala Ala Ala Gly Gly Cys Thr Gly Ala Ala Gly Ala Cys Ala Cys 
            260                 265                 270         


Thr Gly Cys Cys Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Gly Ala Gly Ala Thr Gly Gly Gly Ala Cys Thr Thr Thr Gly 
    290                 295                 300                 


Cys Thr Cys Ala Thr Thr Ala Cys Thr Thr Thr Cys Ala Gly Ala Cys 
305                 310                 315                 320 


Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys 
                325                 330                 335     


Cys Ala Ala Gly Gly Gly Ala Cys Cys Ala Cys Gly Gly Thr Cys Ala 
            340                 345                 350         


Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala Gly Gly Cys Gly Gly 
        355                 360                 365             


Ala Gly Gly Thr Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Gly 
    370                 375                 380                 


Gly Gly Ala Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Gly Cys Gly 
385                 390                 395                 400 


Gly Ala Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Cys Gly Ala 
                405                 410                 415     


Thr Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys Ala Gly 
            420                 425                 430         


Thr Cys Thr Cys Cys Ala Thr Cys Cys Thr Cys Cys Cys Thr Gly Thr 
        435                 440                 445             


Cys Thr Gly Cys Ala Thr Cys Thr Gly Thr Gly Gly Gly Ala Gly Ala 
    450                 455                 460                 


Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala Cys Thr 
465                 470                 475                 480 


Thr Gly Cys Ala Ala Gly Gly Cys Cys Ala Gly Thr Gly Cys Gly Gly 
                485                 490                 495     


Cys Thr Gly Thr Gly Gly Gly Thr Ala Cys Gly Thr Ala Thr Gly Thr 
            500                 505                 510         


Thr Gly Cys Gly Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly 
        515                 520                 525             


Ala Ala Ala Cys Cys Ala Gly Gly Gly Ala Ala Ala Gly Cys Ala Cys 
    530                 535                 540                 


Cys Thr Ala Ala Gly Cys Thr Cys Cys Thr Gly Ala Thr Cys Thr Ala 
545                 550                 555                 560 


Thr Thr Cys Gly Gly Cys Ala Thr Cys Cys Thr Ala Cys Cys Gly Cys 
                565                 570                 575     


Ala Ala Ala Ala Gly Gly Gly Gly Ala Gly Thr Cys Cys Cys Ala Thr 
            580                 585                 590         


Cys Ala Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly 
        595                 600                 605             


Thr Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Cys Ala Gly Ala Thr 
    610                 615                 620                 


Thr Thr Cys Ala Cys Thr Cys Thr Cys Ala Cys Cys Ala Thr Cys Ala 
625                 630                 635                 640 


Gly Cys Ala Gly Thr Cys Thr Gly Cys Ala Ala Cys Cys Thr Gly Ala 
                645                 650                 655     


Ala Gly Ala Thr Thr Thr Cys Gly Cys Ala Ala Cys Thr Thr Ala Cys 
            660                 665                 670         


Thr Ala Cys Thr Gly Thr Cys Ala Cys Cys Ala Ala Thr Ala Thr Thr 
        675                 680                 685             


Ala Cys Ala Cys Cys Thr Ala Thr Cys Cys Thr Cys Thr Ala Thr Thr 
    690                 695                 700                 


Cys Ala Cys Gly Thr Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Cys 
705                 710                 715                 720 


Ala Cys Cys Ala Ala Gly Cys Thr Cys Gly Ala Gly Ala Thr Cys Ala 
                725                 730                 735     


Ala Gly 
        


<210>  139
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoreceptor tyrosine-based activation motif


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Xaa is Leu or Ile

<400>  139

Tyr Xaa Xaa Xaa 
1               


