                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
       Aqeilan, Rami
       Repudi, Srinivas
 
<120>  METHOD FOR THE TREATMENT OF WWOX ASSOCIATED DISEASES

<130>  70-078 PCT

<150>  US 63/064,181
<151>  2020-08-11

<150>  US 63/167,277
<151>  2021-03-29

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1245
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcagcgc tgcgctacgc ggggctggac gacacggaca gtgaggacga gctgcctccg       60

ggctgggagg agagaaccac caaggacggc tgggtttact acgccaatca caccgaggag      120

aagactcagt gggaacatcc aaaaactgga aaaagaaaac gagtggcagg agatttgcca      180

tacggatggg aacaagaaac tgatgagaac ggacaagtgt tttttgttga ccatataaat      240

aaaagaacca cctacttgga cccaagactg gcgtttactg tggatgataa tccgaccaag      300

ccaaccaccc ggcaaagata cgacggcagc accactgcca tggaaattct ccagggccgg      360

gatttcactg gcaaagtggt tgtggtcact ggagctaatt caggaatagg gttcgaaacc      420

gccaagtctt ttgccctcca tggtgcacat gtgatcttgg cctgcaggaa catggcaagg      480

gcgagtgaag cagtgtcacg cattttagaa gaatggcata aagccaaggt agaagcaatg      540

accctggacc tcgctctgct ccgtagcgtg cagcattttg ctgaagcatt caaggccaag      600

aatgtgcctc ttcatgtgct tgtgtgcaac gcagcaactt ttgctctacc ctggagtctc      660

accaaagatg gcctggagac cacctttcaa gtgaatcatc tggggcactt ctaccttgtc      720

cagctcctcc aggatgtttt gtgccgctca gctcctgccc gtgtcattgt ggtctcctca      780

gagtcccatc gatttacaga tattaacgac tccttgggaa aactggactt cagtcgcctc      840

tctccaacaa aaaacgacta ttgggcgatg ctggcttata acaggtccaa gctctgcaac      900

atcctcttct ccaacgagct gcaccgtcgc ctctccccac gcggggtcac gtcgaacgca      960

gtgcatcctg gaaatatgat gtactccaac attcatcgca gctggtgggt gtacacactg     1020

ctgtttacct tggcgaggcc tttcaccaag tccatgcaac agggagctgc caccaccgtg     1080

tactgtgctg ctgtcccaga actggagggt ctgggaggga tgtacttcaa caactgctgc     1140

cgctgcatgc cctcaccaga agctcagagc gaagagacgg cccggaccct gtgggcgctc     1200

agcgagaggc tgatccaaga acggcttggc agccagtccg gctaa                     1245


<210>  2
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Leu Arg Tyr Ala Gly Leu Asp Asp Thr Asp Ser Glu Asp 
1               5                   10                  15      


Glu Leu Pro Pro Gly Trp Glu Glu Arg Thr Thr Lys Asp Gly Trp Val 
            20                  25                  30          


Tyr Tyr Ala Asn His Thr Glu Glu Lys Thr Gln Trp Glu His Pro Lys 
        35                  40                  45              


Thr Gly Lys Arg Lys Arg Val Ala Gly Asp Leu Pro Tyr Gly Trp Glu 
    50                  55                  60                  


Gln Glu Thr Asp Glu Asn Gly Gln Val Phe Phe Val Asp His Ile Asn 
65                  70                  75                  80  


Lys Arg Thr Thr Tyr Leu Asp Pro Arg Leu Ala Phe Thr Val Asp Asp 
                85                  90                  95      


Asn Pro Thr Lys Pro Thr Thr Arg Gln Arg Tyr Asp Gly Ser Thr Thr 
            100                 105                 110         


Ala Met Glu Ile Leu Gln Gly Arg Asp Phe Thr Gly Lys Val Val Val 
        115                 120                 125             


Val Thr Gly Ala Asn Ser Gly Ile Gly Phe Glu Thr Ala Lys Ser Phe 
    130                 135                 140                 


Ala Leu His Gly Ala His Val Ile Leu Ala Cys Arg Asn Met Ala Arg 
145                 150                 155                 160 


Ala Ser Glu Ala Val Ser Arg Ile Leu Glu Glu Trp His Lys Ala Lys 
                165                 170                 175     


Val Glu Ala Met Thr Leu Asp Leu Ala Leu Leu Arg Ser Val Gln His 
            180                 185                 190         


Phe Ala Glu Ala Phe Lys Ala Lys Asn Val Pro Leu His Val Leu Val 
        195                 200                 205             


Cys Asn Ala Ala Thr Phe Ala Leu Pro Trp Ser Leu Thr Lys Asp Gly 
    210                 215                 220                 


Leu Glu Thr Thr Phe Gln Val Asn His Leu Gly His Phe Tyr Leu Val 
225                 230                 235                 240 


Gln Leu Leu Gln Asp Val Leu Cys Arg Ser Ala Pro Ala Arg Val Ile 
                245                 250                 255     


Val Val Ser Ser Glu Ser His Arg Phe Thr Asp Ile Asn Asp Ser Leu 
            260                 265                 270         


Gly Lys Leu Asp Phe Ser Arg Leu Ser Pro Thr Lys Asn Asp Tyr Trp 
        275                 280                 285             


Ala Met Leu Ala Tyr Asn Arg Ser Lys Leu Cys Asn Ile Leu Phe Ser 
    290                 295                 300                 


Asn Glu Leu His Arg Arg Leu Ser Pro Arg Gly Val Thr Ser Asn Ala 
305                 310                 315                 320 


Val His Pro Gly Asn Met Met Tyr Ser Asn Ile His Arg Ser Trp Trp 
                325                 330                 335     


Val Tyr Thr Leu Leu Phe Thr Leu Ala Arg Pro Phe Thr Lys Ser Met 
            340                 345                 350         


Gln Gln Gly Ala Ala Thr Thr Val Tyr Cys Ala Ala Val Pro Glu Leu 
        355                 360                 365             


Glu Gly Leu Gly Gly Met Tyr Phe Asn Asn Cys Cys Arg Cys Met Pro 
    370                 375                 380                 


Ser Pro Glu Ala Gln Ser Glu Glu Thr Ala Arg Thr Leu Trp Ala Leu 
385                 390                 395                 400 


Ser Glu Arg Leu Ile Gln Glu Arg Leu Gly Ser Gln Ser Gly 
                405                 410                 


<210>  3
<211>  2241
<212>  DNA
<213>  Homo sapiens

<400>  3
gcagtgcgca ggcgtgagcg gtcgggcccc gacgcgcgcg ggtctcgttt ggagcgggag       60

tgagttcctg agcgagtgga cccggcagcg ggcgataggg gggccaggtg cctccacagt      120

cagccatggc agcgctgcgc tacgcggggc tggacgacac ggacagtgag gacgagctgc      180

ctccgggctg ggaggagaga accaccaagg acggctgggt ttactacgcc aatcacaccg      240

aggagaagac tcagtgggaa catccaaaaa ctggaaaaag aaaacgagtg gcaggagatt      300

tgccatacgg atgggaacaa gaaactgatg agaacggaca agtgtttttt gttgaccata      360

taaataaaag aaccacctac ttggacccaa gactggcgtt tactgtggat gataatccga      420

ccaagccaac cacccggcaa agatacgacg gcagcaccac tgccatggaa attctccagg      480

gccgggattt cactggcaaa gtggttgtgg tcactggagc taattcagga atagggttcg      540

aaaccgccaa gtcttttgcc ctccatggtg cacatgtgat cttggcctgc aggaacatgg      600

caagggcgag tgaagcagtg tcacgcattt tagaagaatg gcataaagcc aaggtagaag      660

caatgaccct ggacctcgct ctgctccgta gcgtgcagca ttttgctgaa gcattcaagg      720

ccaagaatgt gcctcttcat gtgcttgtgt gcaacgcagc aacttttgct ctaccctgga      780

gtctcaccaa agatggcctg gagaccacct ttcaagtgaa tcatctgggg cacttctacc      840

ttgtccagct cctccaggat gttttgtgcc gctcagctcc tgcccgtgtc attgtggtct      900

cctcagagtc ccatcgattt acagatatta acgactcctt gggaaaactg gacttcagtc      960

gcctctctcc aacaaaaaac gactattggg cgatgctggc ttataacagg tccaagctct     1020

gcaacatcct cttctccaac gagctgcacc gtcgcctctc cccacgcggg gtcacgtcga     1080

acgcagtgca tcctggaaat atgatgtact ccaacattca tcgcagctgg tgggtgtaca     1140

cactgctgtt taccttggcg aggcctttca ccaagtccat gcaacaggga gctgccacca     1200

ccgtgtactg tgctgctgtc ccagaactgg agggtctggg agggatgtac ttcaacaact     1260

gctgccgctg catgccctca ccagaagctc agagcgaaga gacggcccgg accctgtggg     1320

cgctcagcga gaggctgatc caagaacggc ttggcagcca gtccggctaa gtggagctca     1380

gagcggatgg gcacacacac ccgccctgtg tgtgtcccct cacgcaagtg ccagggctgg     1440

gccccttcca aatgtccctc caacacagat ccgcaagagt aaaggaaata agagcagtca     1500

caacagagtg aaaaatctta agtaccaatg ggaagcaggg aattcctggg gtaaagtatc     1560

acttttctgg ggctgggcta ggcataggtc tctttgcttt ctggtggtgg cctgtttgaa     1620

agtaaaaacc tgcttggtgt gtaggttccg tatctccctg gagaagcacc agcaattctc     1680

tttcttttac tgttatagaa tagcctgagg tcccctcgtc ccatccagct accaccacgg     1740

ccaccactgc agccgggggc tggccttctc ctacttaggg aagaaaaagc aagtgttcac     1800

tgctccttgc tgcattgatc caggagataa ttgtttcatt catcctgacc aagactgagc     1860

cagcttagca actgctgggg agacaaatct cagaaccttg tcccagccag tgaggatgac     1920

agtgacaccc agagggagta gaatacgcag aactaccagg tggcaaagta cttgtcatag     1980

actcctttgc taatgctatg caaaaaattc tttagagatt ataacaaatt tttcaaatca     2040

ttccttagat accttgaaag gcaggaaggg aagcgtatat acttaagaat acacaggata     2100

ttttgggggg cagagaataa aacgttagtt aatccctttg tctgtcaatc acagtctcag     2160

ttctcttgct ttcacattgt acttaaacct cctgctgtgc ctcgcatcct atgcttaata     2220

aaagaacatg cttgaatatc a                                               2241


<210>  4
<211>  572
<212>  DNA
<213>  Homo sapiens

<400>  4
actacaaacc gagtatctgc agagggccct gcgtatgagt gcaagtgggt tttaggacca       60

ggatgaggcg gggtgggggt gcctacctga cgaccgaccc cgacccactg gacaagcacc      120

caacccccat tccccaaatt gcgcatcccc tatcagagag ggggagggga aacaggatgc      180

ggcgaggcgc gtgcgcactg ccagcttcag caccgcggac agtgccttcg cccccgcctg      240

gcggcgcgcg ccaccgccgc ctcagcactg aaggcgcgct gacgtcactc gccggtcccc      300

cgcaaactcc ccttcccggc caccttggtc gcgtccgcgc cgccgccggc ccagccggac      360

cgcaccacgc gaggcgcgag ataggggggc acgggcgcga ccatctgcgc tgcggcgccg      420

gcgactcagc gctgcctcag tctgcggtgg gcagcggagg agtcgtgtcg tgcctgagag      480

cgcagctgtg ctcctgggca ccgcgcagtc cgcccccgcg gctcctggcc agaccacccc      540

taggaccccc tgccccaagt cgcagccttc ga                                    572


<210>  5
<211>  6284
<212>  DNA
<213>  Homo sapiens

<400>  5
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcaatt cagtcgataa ctataacggt cctaaggtag      180

cgatttaaat acgcgctctc ttaaggtagc cccgggacgc gtcaattgac tacaaaccga      240

gtatctgcag agggccctgc gtatgagtgc aagtgggttt taggaccagg atgaggcggg      300

gtgggggtgc ctacctgacg accgaccccg acccactgga caagcaccca acccccattc      360

cccaaattgc gcatccccta tcagagaggg ggaggggaaa caggatgcgg cgaggcgcgt      420

gcgcactgcc agcttcagca ccgcggacag tgccttcgcc cccgcctggc ggcgcgcgcc      480

accgccgcct cagcactgaa ggcgcgctga cgtcactcgc cggtcccccg caaactcccc      540

ttcccggcca ccttggtcgc gtccgcgccg ccgccggccc agccggaccg caccacgcga      600

ggcgcgagat aggggggcac gggcgcgacc atctgcgctg cggcgccggc gactcagcgc      660

tgcctcagtc tgcggtgggc agcggaggag tcgtgtcgtg cctgagagcg cagctgtgct      720

cctgggcacc gcgcagtccg cccccgcggc tcctggccag accaccccta ggaccccctg      780

ccccaagtcg cagccttcga gctagcgttt aaacttaagc ttggtaccgg ccgctgcggc      840

cctcgagcaa gctggctagt taagctatca acaagtttgt acaaaaaagc aggctttaaa      900

ggaaccaatt cagtcgagaa ttcgtcgact ggatccggta ccgaggagat ctgccgccgc      960

gatcgccgca gtgcgcaggc gtgagcggtc gggccccgac gcgcgcgggt ctcgtttgga     1020

gcgggagtga gttcctgagc gagtggaccc ggcagcgggc gatagggggg ccaggtgcct     1080

ccacagtcag ccatggcagc gctgcgctac gcggggctgg acgacacgga cagtgaggac     1140

gagctgcctc cgggctggga ggagagaacc accaaggacg gctgggttta ctacgccaat     1200

cacaccgagg agaagactca gtgggaacat ccaaaaactg gaaaaagaaa acgagtggca     1260

ggagatttgc catacggatg ggaacaagaa actgatgaga acggacaagt gttttttgtt     1320

gaccatataa ataaaagaac cacctacttg gacccaagac tggcgtttac tgtggatgat     1380

aatccgacca agccaaccac ccggcaaaga tacgacggca gcaccactgc catggaaatt     1440

ctccagggcc gggatttcac tggcaaagtg gttgtggtca ctggagctaa ttcaggaata     1500

gggttcgaaa ccgccaagtc ttttgccctc catggtgcac atgtgatctt ggcctgcagg     1560

aacatggcaa gggcgagtga agcagtgtca cgcattttag aagaatggca taaagccaag     1620

gtagaagcaa tgaccctgga cctcgctctg ctccgtagcg tgcagcattt tgctgaagca     1680

ttcaaggcca agaatgtgcc tcttcatgtg cttgtgtgca acgcagcaac ttttgctcta     1740

ccctggagtc tcaccaaaga tggcctggag accacctttc aagtgaatca tctggggcac     1800

ttctaccttg tccagctcct ccaggatgtt ttgtgccgct cagctcctgc ccgtgtcatt     1860

gtggtctcct cagagtccca tcgatttaca gatattaacg actccttggg aaaactggac     1920

ttcagtcgcc tctctccaac aaaaaacgac tattgggcga tgctggctta taacaggtcc     1980

aagctctgca acatcctctt ctccaacgag ctgcaccgtc gcctctcccc acgcggggtc     2040

acgtcgaacg cagtgcatcc tggaaatatg atgtactcca acattcatcg cagctggtgg     2100

gtgtacacac tgctgtttac cttggcgagg cctttcacca agtccatgca acagggagct     2160

gccaccaccg tgtactgtgc tgctgtccca gaactggagg gtctgggagg gatgtacttc     2220

aacaactgct gccgctgcat gccctcacca gaagctcaga gcgaagagac ggcccggacc     2280

ctgtgggcgc tcagcgagag gctgatccaa gaacggcttg gcagccagtc cggctaagtg     2340

gagctcagag cggatgggca cacacacccg ccctgtgtgt gtcccctcac gcaagtgcca     2400

gggctgggcc ccttccaaat gtccctccaa cacagatccg caagagtaaa ggaaataaga     2460

gcagtcacaa cagagtgaaa aatcttaagt accaatggga agcagggaat tcctggggta     2520

aagtatcact tttctggggc tgggctaggc ataggtctct ttgctttctg gtggtggcct     2580

gtttgaaagt aaaaacctgc ttggtgtgta ggttccgtat ctccctggag aagcaccagc     2640

aattctcttt cttttactgt tatagaatag cctgaggtcc cctcgtccca tccagctacc     2700

accacggcca ccactgcagc cgggggctgg ccttctccta cttagggaag aaaaagcaag     2760

tgttcactgc tccttgctgc attgatccag gagataattg tttcattcat cctgaccaag     2820

actgagccag cttagcaact gctggggaga caaatctcag aaccttgtcc cagccagtga     2880

ggatgacagt gacacccaga gggagtagaa tacgcagaac taccaggtgg caaagtactt     2940

gtcatagact cctttgctaa tgctatgcaa aaaattcttt agagattata acaaattttt     3000

caaatcattc cttagatacc ttgaaaggca ggaagggaag cgtatatact taagaataca     3060

caggatattt tggggggcag agaataaaac gttagttaat ccctttgtct gtcaatcaca     3120

gtctcagttc tcttgctttc acattgtact taaacctcct gctgtgcctc gcatcctatg     3180

cttaataaaa gaacatgctt gaatatcatt gagtttaaac ccgctgatca gcctcgactg     3240

tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg     3300

aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga     3360

gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg     3420

aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag gcggaaagaa     3480

ccagatcctc tcttaaggta gcatcgagat ttaaattagg gataacaggg taatggcgcg     3540

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     3600

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     3660

gcgagcgagc gcgcagctgc ctgcaggggc gcctgatgcg gtattttctc cttacgcatc     3720

tgtgcggtat ttcacaccgc atacgtcaaa gcaaccatag tacgcgccct gtagcggcgc     3780

attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct     3840

agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg     3900

tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga     3960

ccccaaaaaa cttgatttgg gtgatggttc acgtagtggg ccatcgccct gatagacggt     4020

ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg     4080

aacaacactc aaccctatct cgggctattc ttttgattta taagggattt tgccgatttc     4140

ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat     4200

attaacgttt acaattttat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt     4260

aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc     4320

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc     4380

accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt     4440

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg     4500

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     4560

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt     4620

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     4680

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     4740

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     4800

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca     4860

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     4920

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     4980

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     5040

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     5100

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac     5160

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     5220

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     5280

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     5340

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     5400

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     5460

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     5520

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     5580

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     5640

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     5700

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     5760

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa     5820

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     5880

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     5940

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     6000

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     6060

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     6120

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     6180

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     6240

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgt                      6284


