                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> TREATMENTS FOR RETINAL DEGENERATIVE DISEASES

<130> PAT058930-WO-PCT

<140>
<141>

<150> 63/063,877
<151> 2020-08-10

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1
actcaccctc cctaaaccag                                                   20


<210> 2
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 2
aagggaacga ttccatcact a                                                 21


<210> 3
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 3
ttctacagat ttgctctact a                                                 21


<210> 4
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 4
ctcctcctac ccggctttaa a                                                 21


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 5
cagaattatc ccaaccgata t                                                 21


<210> 6
<211> 24
<212> PRT
<213> Homo sapiens

<400> 6
Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg 
1               5                   10                  15      


Pro Gly Trp Val Glu Tyr Phe Ile 
            20                  


<210> 7
<211> 540
<212> PRT
<213> Homo sapiens

<400> 7
Met Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe 
1               5                   10                  15      


Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro 
            20                  25                  30          


Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu 
        35                  40                  45              


Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg 
    50                  55                  60                  


Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu 
65                  70                  75                  80  


Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln 
                85                  90                  95      


Pro Arg Thr Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu 
            100                 105                 110         


Pro Ala Glu Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile 
        115                 120                 125             


Pro Tyr Asn Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val 
    130                 135                 140                 


Gln Glu Thr Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala 
145                 150                 155                 160 


Leu Gln Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly 
                165                 170                 175     


Pro Leu Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser 
            180                 185                 190         


Ser Gly His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala 
        195                 200                 205             


Gly Ala Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser 
    210                 215                 220                 


Val Ser Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser 
                245                 250                 255     


Ser Ser Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly 
            260                 265                 270         


Ala Glu Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu 
        275                 280                 285             


Ala Pro Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro 
    290                 295                 300                 


Val Asn Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser 
305                 310                 315                 320 


Thr Val Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val 
                325                 330                 335     


Pro Ser Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn 
            340                 345                 350         


Ser Thr Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val 
        355                 360                 365             


Leu Thr Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg 
    370                 375                 380                 


Asn Glu Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly 
385                 390                 395                 400 


Ser Ser Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser 
                405                 410                 415     


Glu Leu Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe 
            420                 425                 430         


Ser Gly Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly 
        435                 440                 445             


Met Gly Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly 
    450                 455                 460                 


Thr Phe Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu 
465                 470                 475                 480 


Gly Asn Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln 
                485                 490                 495     


Ala Asp Arg Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser 
            500                 505                 510         


Pro Gly Ala Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val 
        515                 520                 525             


Thr Leu Leu Val Val Leu Tyr Arg Arg Arg Leu His 
    530                 535                 540 


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
gtagcgaacg tgtccggcgt                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 9
gaccggaacg atctcgcgta                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
ggcagtcgtt cggttgatat                                                   20


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
gcttgagcac atacgcgaat                                                   20


<210> 12
<211> 4628
<212> DNA
<213> Homo sapiens

<400> 12
gaacgtagct agctgcaagc agaggccggc atgaccaccg agcagcgacg cagcctgcaa       60

gccttccagg attatatccg gaagaccctg gaccctacct acatcctgag ctacatggcc      120

ccctggttta gggaggaaga ggtgcagtat attcaggctg agaaaaacaa caagggccca      180

atggaggctg ccacactttt tctcaagttc ctgttggagc tccaggagga aggctggttc      240

cgtggctttt tggatgccct agaccatgca ggttattctg gactttatga agccattgaa      300

agttgggatt tcaaaaaaat tgaaaagttg gaggagtata gattactttt aaaacgttta      360

caaccagaat ttaaaaccag aattatccca accgatatca tttctgatct gtctgaatgt      420

ttaattaatc aggaatgtga agaaattcta cagatttgct ctactaaggg gatgatggca      480

ggtgcagaga aattggtgga atgccttctc agatcagaca aggaaaactg gcccaaaact      540

ttgaaacttg ctttggagaa agaaaggaac aagttcagtg aactgtggat tgtagagaaa      600

ggtataaaag atgttgaaac agaagatctt gaggataaga tggaaacttc tgacatacag      660

attttctacc aagaagatcc agaatgccag aatcttagtg agaattcatg tccaccttca      720

gaagtgtctg atacaaactt gtacagccca tttaaaccaa gaaattacca attagagctt      780

gctttgcctg ctatgaaagg aaaaaacaca ataatatgtg ctcctacagg ttgtggaaaa      840

acctttgttt cactgcttat atgtgaacat catcttaaaa aattcccaca aggacaaaag      900

gggaaagttg tcttttttgc gaatcagatc ccagtgtatg aacagcagaa atctgtattc      960

tcaaaatact ttgaaagaca tgggtataga gttacaggca tttctggagc aacagctgag     1020

aatgtcccag tggaacagat tgttgagaac aatgacatca tcattttaac tccacagatt     1080

cttgtgaaca accttaaaaa gggaacgatt ccatcactat ccatctttac tttgatgata     1140

tttgatgaat gccacaacac tagtaaacaa cacccgtaca atatgatcat gtttaattat     1200

ctagatcaga aacttggagg atcttcaggc ccactgcccc aggtcattgg gctgactgcc     1260

tcggttggtg ttggggatgc caaaaacaca gatgaagcct tggattatat ctgcaagctg     1320

tgtgcttctc ttgatgcgtc agtgatagca acagtcaaac acaatctgga ggaactggag     1380

caagttgttt ataagcccca gaagtttttc aggaaagtgg aatcacggat tagcgacaaa     1440

tttaaataca tcatagctca gctgatgagg gacacagaga gtctggcaaa gagaatctgc     1500

aaagacctcg aaaacttatc tcaaattcaa aatagggaat ttggaacaca gaaatatgaa     1560

caatggattg ttacagttca gaaagcatgc atggtgttcc agatgccaga caaagatgaa     1620

gagagcagga tttgtaaagc cctgttttta tacacttcac atttgcggaa atataatgat     1680

gccctcatta tcagtgagca tgcacgaatg aaagatgctc tggattactt gaaagacttc     1740

ttcagcaatg tccgagcagc aggattcgat gagattgagc aagatcttac tcagagattt     1800

gaagaaaagc tgcaggaact agaaagtgtt tccagggatc ccagcaatga gaatcctaaa     1860

cttgaagacc tctgcttcat cttacaagaa gagtaccact taaacccaga gacaataaca     1920

attctctttg tgaaaaccag agcacttgtg gacgctttaa aaaattggat tgaaggaaat     1980

cctaaactca gttttctaaa acctggcata ttgactggac gtggcaaaac aaatcagaac     2040

acaggaatga ccctcccggc acagaagtgt atattggatg cattcaaagc cagtggagat     2100

cacaatattc tgattgccac ctcagttgct gatgaaggca ttgacattgc acagtgcaat     2160

cttgtcatcc tttatgagta tgtgggcaat gtcatcaaaa tgatccaaac cagaggcaga     2220

ggaagagcaa gaggtagcaa gtgcttcctt ctgactagta atgctggtgt aattgaaaaa     2280

gaacaaataa acatgtacaa agaaaaaatg atgaatgact ctattttacg ccttcagaca     2340

tgggacgaag cagtatttag ggaaaagatt ctgcatatac agactcatga aaaattcatc     2400

agagatagtc aagaaaaacc aaaacctgta cctgataagg aaaataaaaa actgctctgc     2460

agaaagtgca aagccttggc atgttacaca gctgacgtaa gagtgataga ggaatgccat     2520

tacactgtgc ttggagatgc ttttaaggaa tgctttgtga gtagaccaca tcccaagcca     2580

aagcagtttt caagttttga aaaaagagca aagatattct gtgcccgaca gaactgcagc     2640

catgactggg gaatccatgt gaagtacaag acatttgaga ttccagttat aaaaattgaa     2700

agttttgtgg tggaggatat tgcaactgga gttcagacac tgtactcgaa gtggaaggac     2760

tttcattttg agaagatacc atttgatcca gcagaaatgt ccaaatgata tcaggtcctc     2820

aatcttcagc tacagggaat gagtaacttt gagtggagaa gaaacaaaca tagtgggtat     2880

aatcatggat cgcttgtacc cctgtgaaaa tatatttttt aaaaatatct ttagcagttt     2940

gtactatatt atatatgcaa agcacaaatg agtgaatcac agcactgagt attttgtagg     3000

ccaacagagc tcatagtact tgggaaaaat taaaaagcct catttctagc cttcttttta     3060

gagtcaactg ccaacaaaca cacagtaatc actctgtaca cactgggata gatgaatgaa     3120

tggaatgttg ggaattttta tctccctttg tctccttaac ctactgtaaa ctggcttttg     3180

cccttaacaa tctactgaaa ttgttctttt gaaggttacc agtgactctg gttgccaaat     3240

ccactgggca cttcttaacc ttctatttga cctctgcgca tttggccctg ttgagcactc     3300

ttcttgaagc tctccctggg cttctctctc ttctagttct attctagtct ttttttattg     3360

agtcctcctc tttgctgatc ccttccaagg gttcaatata tatacatgta tatactgtac     3420

atatgtatat gtaactaata tacatacata caggtatgta tatgtaatgg ttatatgtac     3480

tcatgttcct ggtgtagcaa cgtgtggtat ggctacacag agaacatgag aacataaagc     3540

catttttatg cttactacta aaagctgtcc actgtagagt tgctgtatgt agcaatgtgt     3600

atccactcta cagtggtcag cttttagtag agagcataaa aatgataaaa tacttcttga     3660

aaacttagtt tactatacat cttgccctat taatatgttc tcttaacgtg tgccattgtt     3720

ctctttgacc attttcctat aatgatgttg atgttcaaca cctggactga atgtctgttc     3780

tcagatccct tggatgttac agatgaggca gtctgactgt cctttctact tgaaagatta     3840

gaatatgtat ccaaatggca ttcacgtgtc acttagcaag gtttgctgat gcttcaaaga     3900

gcttagtttg cggtttcctg gacgtggaaa caagtatctg agttccctgg agatcaacgg     3960

gatgaggtgt tacagctgcc tccctcttca tgcaatctgg tgagcagtgg tgcaggcggg     4020

gagccagaga aacttgccag ttatataact tctctttggc ttttcttcat ctgtaaaaca     4080

aggataatac tgaactgtaa gggttagtgg agagttttta attaaaagaa tgtgtgaaaa     4140

gtacatgaca cagtagttgc ttgataatag ttactagtag tagtattctt actaagaccc     4200

aatacaaatg gattatttaa accaagttta tgagttggtt ttttttcatt ttctatttgt     4260

attttattaa gagtgtcttt tcttatgtga ttttttttaa ttgctatttg atatggtttg     4320

gctatatgtc cccacccaaa tctcatcttg aattataatc cccatgtgtc aagggaggga     4380

cctgacggga ggtgattgga tcacgggggc agttgtcccc atgctgttct tgggatagtg     4440

agttagttct catgagatct gatggtttta taagtgtttg acaattcctc ctttacacac     4500

actctctctc tcatctgctg ccatgtaaga cttgcctgct tccccttctg ccatgattgt     4560

aagtttcctg aggcctcctc agccatgtgg aactgtgaat ctattaagcc tcttttcttt     4620

ataaatga                                                              4628


<210> 13
<211> 925
<212> PRT
<213> Homo sapiens

<400> 13
Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile 
1               5                   10                  15      


Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp 
            20                  25                  30          


Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys 
        35                  40                  45              


Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala 
65                  70                  75                  80  


Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys 
                85                  90                  95      


Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro 
            100                 105                 110         


Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser 
        115                 120                 125             


Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser 
    130                 135                 140                 


Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu 
145                 150                 155                 160 


Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu 
                165                 170                 175     


Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile 
            180                 185                 190         


Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp 
        195                 200                 205             


Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu 
    210                 215                 220                 


Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro 
225                 230                 235                 240 


Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro Ala Met Lys 
                245                 250                 255     


Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly Lys Thr Phe 
            260                 265                 270         


Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe Pro Gln Gly 
        275                 280                 285             


Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro Val Tyr Glu 
    290                 295                 300                 


Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His Gly Tyr Arg 
305                 310                 315                 320 


Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro Val Glu Gln 
                325                 330                 335     


Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln Ile Leu Val 
            340                 345                 350         


Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile Phe Thr Leu 
        355                 360                 365             


Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His Pro Tyr Asn 
    370                 375                 380                 


Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly Val Gly Asp 
                405                 410                 415     


Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys Leu Cys Ala 
            420                 425                 430         


Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn Leu Glu Glu 
        435                 440                 445             


Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg Lys Val Glu 
    450                 455                 460                 


Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln Leu Met Arg 
465                 470                 475                 480 


Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu Glu Asn Leu 
                485                 490                 495     


Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr Glu Gln Trp 
            500                 505                 510         


Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met Pro Asp Lys 
        515                 520                 525             


Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr Thr Ser His 
    530                 535                 540                 


Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His Ala Arg Met 
545                 550                 555                 560 


Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn Val Arg Ala 
                565                 570                 575     


Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr Gln Arg Phe Glu Glu 
            580                 585                 590         


Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser Asn Glu Asn 
        595                 600                 605             


Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu Tyr His Leu 
    610                 615                 620                 


Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg Ala Leu Val 
625                 630                 635                 640 


Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu Ser Phe Leu 
                645                 650                 655     


Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln Asn Thr Gly 
            660                 665                 670         


Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe Lys Ala Ser 
        675                 680                 685             


Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp Glu Gly Ile 
    690                 695                 700                 


Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr Val Gly Asn 
705                 710                 715                 720 


Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala Arg Gly Ser 
                725                 730                 735     


Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu Lys Glu Gln 
            740                 745                 750         


Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile Leu Arg Leu 
        755                 760                 765             


Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu His Ile Gln 
    770                 775                 780                 


Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro Lys Pro Val 
785                 790                 795                 800 


Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys Lys Ala Leu 
                805                 810                 815     


Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys His Tyr Thr 
            820                 825                 830         


Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg Pro His Pro 
        835                 840                 845             


Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys Ile Phe Cys 
    850                 855                 860                 


Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val Lys Tyr Lys 
865                 870                 875                 880 


Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val Val Glu Asp 
                885                 890                 895     


Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys Asp Phe His 
            900                 905                 910         


Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys 
        915                 920                 925 


