б

<110>  ϾƼ޹˾
 
<120>  ̻ϸ;

<130>  BHCN24

<160>  88   

<170>  PatentIn version 3.5

<210>  1
<211>  242
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFv-1

<400>  1
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
                5                   10                  15

Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
            20                  25                  30

Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45

Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65                  70                  75                  80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu
        115                 120                 125

Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys
    130                 135                 140
 
Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg
145                 150                 155                 160

Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser
                165                 170                 175

Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile
            180                 185                 190

Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln
        195                 200                 205

Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly
    210                 215                 220

Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
225                 230                 235                 240

Ser Ser


<210>  2
<211>  726
<212>  DNA
<213>  ˹

<220>
<223>  CD19 scFv-1

<400>  2
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc    60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc    360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg    420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc    480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac    540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt    600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat    660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc    720

tcctca                                                               726


<210>  3
<211>  25
<212>  PRT
<213>  ˹

<220>
<223>  CD8Ĥṹ

<400>  3
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                5                   10                  15

Ser Leu Val Ile Thr Leu Tyr Cys Lys
            20                  25


<210>  4
<211>  75
<212>  PRT
<213>  ˹

<220>
<223>  CD8Ĥṹ

<400>  4
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     60

accctttact gcaaa                                                      75


<210>  5
<211>  27
<212>  PRT
<213>  ˹

<220>
<223>  CD28Ĥṹ

<400>  5
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                5                   10                  15

Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25


<210>  6
<211>  81
<212>  DNA
<213>  ˹

<220>
<223>  CD28Ĥṹ

<400>  6
ttttgggtcc tcgtcgtagt tggaggggta cttgcctgtt atagcctcct ggttaccgta     60

gcatttatta tattctgggt g                                               81


<210>  7
<211>  41
<212>  PRT
<213>  ˹

<220>
<223>  CD28̼ṹ

<400>  7
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                5                   10                  15

Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30

Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40


<210>  8
<211>  123
<212>  DNA
<213>  ˹

<220>
<223>  CD28̼ṹ

<400>  8
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc    120

tcc                                                                  123


<210>  9
<211>  40
<212>  PRT
<213>  ˹

<220>
<223>  4-1BB̼ṹ

<400>  9
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                5                   10                  15

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
            20                  25                  30

Glu Glu Glu Glu Gly Gly Cys Glu
        35                  40


<210>  10
<211>  120
<212>  DNA
<213>  ˹

<220>
<223>  4-1BB̼ṹ

<400>  10
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     60

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     120


<210>  11
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  CD3źŴṹ

<400>  11
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                5                   10                  15

Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60

Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
65                  70                  75                  80

Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
                85                  90                  95

Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
            100                 105                 110

Arg


<210>  12
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  CD3źŴṹ

<400>  12
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac    180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag    240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac    300

acctacgacg cccttcacat gcaggccctg ccccctcgc                           339


<210>  13
<211>  114
<212>  PRT
<213>  ˹

<220>
<223>  CD3źŴṹ

<400>  13
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln
                5                   10                  15

Gly Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Phe Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
    50                  55                  60

Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
65                  70                  75                  80

Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser
                85                  90                  95

Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro
            100                 105                 110
Pro Arg


<210>  14
<211>  342
<212>  DNA
<213>  ˹

<220>
<223>  CD3źŴṹ

<400>  14
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctttaacg agctcaatct aggacgaaga gaggagttcg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg    180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc    240

gagcgccgga ggggcaaggg gcacgatggc cttttccagg gtctcagtac agccaccaag    300

gacacctttg acgcccttca catgcaggcc ctgccccctc gc                       342


<210>  15
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  B2Mź

<400>  15
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser
                5                   10                  15

Gly Leu Glu Ala
            20


<210>  16
<211>  60
<212>  DNA
<213>  ˹

<220>
<223>  B2Mź

<400>  16
atgtcccgct ctgttgcttt ggctgtgctg gcccttttgt cccttagcgg actggaggcc     60


<210>  17
<211>  21
<212>  PRT
<213>  ˹

<220>
<223>  CD8ź

<400>  17
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
                5                   10                  15

His Ala Ala Arg Pro
            20


<210>  18
<211>  63
<212>  DNA
<213>  ˹

<220>
<223>  CD8ź

<400>  18
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccg                                                                   63


<210>  19
<211>  45
<212>  PRT
<213>  ˹

<220>
<223>  CD8

<400>  19
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
                5                   10                  15

Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
            20                  25                  30

Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
        35                  40                  45


<210>  20
<211>  135
<212>  DNA
<213>  ˹

<220>
<223>  CD8

<400>  20
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg     60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg    120

gacttcgcct gtgat                                                     135


<210>  21
<211>  39
<212>  PRT
<213>  ˹

<220>
<223>  CD28

<400>  21
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
                5                   10                  15

Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30

Phe Pro Gly Pro Ser Lys Pro
        35


<210>  22
<211>  117
<212>  DNA
<213>  ˹

<220>
<223>  CD28

<400>  22
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc     60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagccc       117


<210>  23
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  IgG4

<400>  23
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
                5                   10


<210>  24
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  IgG4

<400>  24
gaaagcaaat acgggccgcc gtgtccaccc tgtccg                               36


<210>  25
<211>  238
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFv-2

<400>  25
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly 
                5                   10                  15

Glu Thr Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly
            20                  25                  30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45

Tyr Gly Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr
65                  70                  75                  80

Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln
        115                 120                 125

Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys
    130                 135                 140

Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met His Phe Val Lys
145                 150                 155                 160

Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Glu
                165                 170                 175

Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn Lys Ala Thr Leu
            180                 185                 190

Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys Leu Ser Ser Leu
        195                 200                 205

Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr Gly Gly Tyr Tyr
    210                 215                 220

Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser
225                 230                 235


<210>  26
<211>  714
<212>  DNA
<213>  ˹

<220>
<223>  CD19 scFv-2

<400>  26
gacatccaga tgacccagag ccctgccagc ctgtctacca gcctgggcga gacagtgacc     60

atccagtgtc aggccagcga ggacatctac tctggcctgg cttggtatca gcagaagccc    120 

ggcaagagcc ctcagctgct gatctacggc gccagcgacc tgcaggacgg cgtgcctagc    180

agattcagcg gcagcggctc cggaacccag tacagcctga agatcaccag catgcagacc    240

gaggacgagg gcgtgtactt ctgccagcaa ggcctgacct accctagaac cttcggagga    300 

ggcaccaagc tggaactgaa gggcggaggc ggaagtggag gcggaggatc tggcggcgga    360

ggctctgaag tgcagctgca gcagtctggc gctgaactgg tccggcctgg cactagcgtg    420

aagctgtcct gcaaggtgtc cggcgacacc atcaccttct actacatgca cttcgtgaag    480

cagaggccag gacagggcct ggaatggatc ggcagaatcg accctgagga cgagagcacc    540

aagtacagcg agaagttcaa gaacaaggcc accctgaccg ccgacaccag cagcaacacc    600

gcctacctga agctgtctag cctgacctcc gaggacaccg ccacctactt ttgcatctac    660

ggcggctact acttcgacta ctggggccag ggcgtgatgg tcaccgtgtc cagc          714


<210>  27
<211>  249
<212>  PRT
<213>  ˹

<220>
<223>  CD22 scFv

<400>  27
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
                5                   10                  15

Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn
            20                  25                  30

Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu
        35                  40                  45

Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala
    50                  55                  60

Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn
65                  70                  75                  80

Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val
                85                  90                  95

Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp
            100                 105                 110

Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Gly Lys
        115                 120                 125

Gly Ser Thr Ser Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile 
    130                 135                 140

Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
145                 150                 155                 160

Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn
                165                 170                 175

Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala
            180                 185                 190

Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly
        195                 200                 205

Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp
    210                 215                 220

Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr Phe
225                 230                 235                 240

Gly Gln Gly Thr Lys Leu Glu Ile Lys
                245


<210>  28
<211>  747
<212>  DNA
<213>  ˹

<220>
<223>  CD22 scFv

<400>  28
caggtgcagc tgcagcagtc tggacccggc ctcgtgaagc ctagccagac cctgtctctg     60

acctgcgcca tcagcggcga tagcgtgtcc agcaatagcg ccgcctggaa ctggatccgg    120

cagagccctt ctagaggcct ggaatggctg ggccggacct actaccggtc caagtggtac    180

aacgactacg ccgtgtccgt gaagtcccgg atcaccatca accccgacac cagcaagaac    240

cagttctccc tgcagctgaa cagcgtgacc cccgaggata ccgccgtgta ctactgcgcc    300

agagaagtga ccggcgacct ggaagatgcc ttcgacatct ggggccaggg cacaatggtc    360

accgtgtcta gcggcagtgg aaagggctca acgtcacccg gttccgggga ggggtcaact    420

aagggcgata ttcagatgac acagagcccc tccagcctgt ccgcctctgt gggagacaga    480

gtgacaatca cctgtcgggc ctcccagacc atctggtcct atctgaattg gtatcagcag    540

cggcctggca aggcccccaa cctgctgatc tatgccgcca gctctctgca gtccggcgtg    600

ccatctagat tcagcggcag aggcagcggc accgatttca ccctgacaat tagcagtctg    660

caggccgagg acttcgccac ctactattgc cagcagagct acagcatccc ccagaccttc    720 

ggccagggaa caaaactgga aatcaaa                                        747


<210>  29
<211>  63
<212>  DNA
<213>  ˹

<220>
<223>  mCD8Ĥṹ

<400>  29
atctgggcac ccttggccgg aatctgcgtg gcccttctgc tgtccttgat catcactctc     60

atc                                                                   63


<210>  30
<211>  21
<212>  PRT
<213>  ˹

<220>
<223>  mCD8Ĥṹ

<400>  30
Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu
                5                   10                  15

Ile Ile Thr Leu Ile
            20


<210>  31
<211>  126
<212>  DNA
<213>  ˹

<220>
<223>  m4-1BB̼ṹ

<400>  31
aggaaaaaat tcccccacat attcaagcaa ccatttaaga agaccactgg agcagctcaa     60

gaggaagatg cttgtagctg ccgatgtcca caggaagaag aaggaggagg aggaggctat    120

gagctg                                                               126


<210>  32
<211>  42
<212>  PRT
<213>  ˹

<220>
<223>  m4-1BB̼ṹ

<400>  32
Arg Lys Lys Phe Pro His Ile Phe Lys Gln Pro Phe Lys Lys Thr Thr
                5                   10                  15
 
Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys Pro Gln Glu
            20                  25                  30

Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu
        35                  40


<210>  33
<211>  327
<212>  DNA
<213>  ˹

<220>
<223>  mCD3ưźŴṹ

<400>  33
agcaggagtg cagagactgc tgccaacctg caggacccca accagctcta caatgagctc     60

aatctagggc gaagagagga atatgacgtc ttggagaaga agcgggctcg ggatccagag    120

atgggaggca aacagcagag gaggaggaac ccccaggaag gcgtatacaa tgcactgcag    180

aaagacaaga tggcagaagc ctacagtgag atcggcacaa aaggcgagag gcggagaggc    240

aaggggcacg atggccttta ccagggtctc agcactgcca ccaaggacac ctatgatgcc    300

ctgcatatgc agaccctggc ccctcgc                                        327


<210>  34
<211>  109
<212>  PRT
<213>  ˹

<220>
<223>  mCD3ưźŴṹ

<400>  34
Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu
                5                   10                  15

Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu
            20                  25                  30

Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg
        35                  40                  45

Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met
    50                  55                  60

Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly
65                  70                  75                  80

Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp
                85                  90                  95

Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg
            100                 105


<210>  35
<211>  135
<212>  DNA
<213>  ˹

<220>
<223>  mCD8

<400>  35
actactacca agccagtgct gcgaactccc tcacctgtgc accctaccgg gacatctcag     60

ccccagagac cagaagattg tcggccccgt ggctcagtga aggggaccgg attggacttc    120

gcctgtgata tttac                                                     135


<210>  36
<211>  45
<212>  PRT
<213>  ˹

<220>
<223>  mCD8

<400>  36
Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr
                5                   10                  15
 
Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser
            20                  25                  30

Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr
        35                  40                  45


<210>  37
<211>  54
<212>  DNA
<213>  ˹

<220>
<223>  T2A

<400>  37
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct           54


<210>  38
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  T2A

<400>  38
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro
                5                   10                  15
Gly Pro


<210>  39
<211>  72
<212>  DNA
<213>  ˹

<220>
<223>  mCD8ź

<400>  39
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt     60

atcctgggga gt                                                         72


<210>  40
<211>  24
<212>  PRT
<213>  ˹

<220>
<223>  mCD8ź

<400>  40
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
                5                   10                  15

Gly Glu Ser Ile Ile Leu Gly Ser
            20


<210>  41
<211>  402
<212>  DNA
<213>  ˹

<220>
<223>  hIL-7

<400>  41
atgttccatg tttcttttag gtatatcttt ggacttcctc ccctgatcct tgttctgttg     60

ccagtagcat catctgattg tgatattgaa ggtaaagatg gcaaacaata tgagagtgtt    120

ctaatggtca gcatcgatca attattggac agcatgaaag aaattggtag caattgcctg    180

aataatgaat ttaacttttt taaaagacat atctgtgatg ctaataaggt taaaggaaga    240

aaaccagctg ccctgggtga agcccaacca acaaagagtt tggaagaaaa taaatcttta    300

aaggaacaga aaaaactgaa tgacttgtgt ttcctaaaga gactattaca agagataaaa    360

acttgttgga ataaaatttt gatgggcact aaagaacact ga                       402


<210>  42
<211>  133
<212>  PRT
<213>  ˹

<220>
<223>  hIL-7

<400>  42
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile
                5                   10                  15

Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys
            20                  25                  30

Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu
        35                  40                  45

Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe
    50                  55                  60

Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Val Lys Gly Arg
65                  70                  75                  80

Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu
                85                  90                  95

Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu
            100                 105                 110

Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met
        115                 120                 125

Gly Thr Lys Glu His
    130


<210>  43
<211>  465
<212>  DNA
<213>  ˹

<220>
<223>  mIL-7

<400>  43
atgttccatg tttcttttag atatatcttt ggaattcctc cactgatcct tgttctgctg     60

cctgtcacat catctgagtg ccacattaaa gacaaagaag gtaaagcata tgagagtgta    120

ctgatgatca gcatcgatga attggacaaa atgacaggaa ctgatagtaa ttgcccgaat    180

aatgaaccaa acttttttag aaaacatgta tgtgatgata caaaggaagc tgcttttcta    240

aatcgtgctg ctcgcaagtt gaagcaattt cttaaaatga atatcagtga agaattcaat    300

gtccacttac taacagtatc acaaggcaca caaacactgg tgaactgcac aagtaaggaa    360

gaaaaaaacg taaaggaaca gaaaaagaat gatgcatgtt tcctaaagag actactgaga    420

gaaataaaaa cttgttggaa taaaattttg aagggcagta tataa                    465


<210>  44
<211>  154
<212>  PRT
<213>  ˹

<220>
<223>  mIL-7

<400>  44
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile
                5                   10                  15
 
Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys
            20                  25                  30

Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu
        35                  40                  45

Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn
    50                  55                  60

Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu
65                  70                  75                  80

Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser
                85                  90                  95

Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr
            100                 105                 110

Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys
        115                 120                 125

Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr
    130                 135                 140

Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile
145                 150


<210>  45
<211>  660
<212>  DNA
<213>  ˹

<220>
<223>  hIL-12

<400>  45
atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt     60

ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac    120

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa    180

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc    240

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga    300

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg    360

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc    420

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg    480

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa    540

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat    600

gctttcagaa ttcgggcagt gactattgac agagtgacga gctatctgaa tgcttcctaa    660


<210>  46
<211>  219
<212>  PRT
<213>  ˹

<220>
<223>  hIL-12

<400>  46
Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu
                5                   10                  15
                 
Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro
            20                  25                  30

Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val
        35                  40                  45

Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys
    50                  55                  60

Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser
65                  70                  75                  80

Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys
                85                  90                  95

Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala
            100                 105                 110

Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr
        115                 120                 125

Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys
    130                 135                 140

Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu
145                 150                 155                 160

Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr
                165                 170                 175

Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys
            180                 185                 190

Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr
        195                 200                 205

Ile Asp Arg Val Thr Ser Tyr Leu Asn Ala Ser
    210                 215


<210>  47
<211>  648
<212>  DNA
<213>  ˹

<220>
<223>  mIL-12

<400>  47
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt     60

ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg    120 

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc    180

actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc    240

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc    300

acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt    360

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca    420

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat    480

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga    540

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc    600

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgcctga                 648


<210>  48
<211>  215
<212>  PRT
<213>  ˹

<220>
<223>  mIL-12

<400>  48
Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala Thr Leu Ala Leu Leu
                5                   10                  15

Asn His Leu Ser Leu Ala Arg Val Ile Pro Val Ser Gly Pro Ala Arg
            20                  25                  30

Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val
        35                  40                  45

Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp
    50                  55                  60

Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr
65                  70                  75                  80

Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg
                85                  90                  95

Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr
            100                 105                 110

Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys
        115                 120                 125

Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His
    130                 135                 140

Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp
145                 150                 155                 160

Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys
                165                 170                 175

Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys
            180                 185                 190

Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val
        195                 200                 205

Met Gly Tyr Leu Ser Ser Ala
    210                 215


<210>  49
<211>  462
<212>  DNA
<213>  ˹

<220>
<223>  hIL-2

<400>  49
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt     60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat    120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc    180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa    240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta    300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa    360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga    420

tggattacct tttgtcaaag catcatctca acactgactt ga                       462
 

<210>  50
<211>  153
<212>  PRT
<213>  ˹

<220>
<223>  hIL-2

<400>  50
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
                5                   10                  15

Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30

Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45

Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60

Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80

Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95

Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110

Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125

Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140

Cys Gln Ser Ile Ile Ser Thr Leu Thr
145                 150


<210>  51
<211>  510
<212>  DNA
<213>  ˹

<220>
<223>  mIL-2

<400>  51
atgtacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc     60

gcacccactt caagctccac ttcaagctct acagcggaag cacagcagca gcagcagcag    120

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc    180

aggatggaga attacaggaa cctgaaactc cccaggatgc tcaccttcaa attttacttg    240

cccaagcagg ccacagaatt gaaagatctt cagtgcctag aagatgaact tggacctctg    300

cggcatgttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc    360

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc    420

caattcgatg atgagtcagc aactgtggtg gactttctga ggagatggat agccttctgt    480

caaagcatca tctcaacaag ccctcaataa                                     510


<210>  52
<211>  169
<212>  PRT
<213>  ˹

<220>
<223>  mIL-2

<400>  52
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
                5                   10                  15

Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30

Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45

Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60

Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80

Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95

Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110

Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125

Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140
  
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160

Gln Ser Ile Ile Ser Thr Ser Pro Gln
                165


<210>  53
<211>  408
<212>  DNA
<213>  ˹

<220>
<223>  hIL-15

<400>  53
atggtattgg gaaccataga tttgtgcagc tgtttcagtg cagggcttcc taaaacagaa     60

gccaactggg tgaatgtaat aagtgatttg aaaaaaattg aagatcttat tcaatctatg    120

catattgatg ctactttata tacggaaagt gatgttcacc ccagttgcaa agtaacagca    180

atgaagtgct ttctcttgga gttacaagtt atttcacttg agtccggaga tgcaagtatt    240

catgatacag tagaaaatct gatcatccta gcaaacaaca gtttgtcttc taatgggaat    300

gtaacagaat ctggatgcaa agaatgtgag gaactggagg aaaaaaatat taaagaattt    360

ttgcagagtt ttgtacatat tgtccaaatg ttcatcaaca cttcttga                 408


<210>  54
<211>  135
<212>  PRT
<213>  ˹

<220>
<223>  hIL-15

<400>  54
Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
                5                   10                  15

Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys
            20                  25                  30

Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr
       35                   40                  45

Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe
    50                  55                  60

Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile
65                  70                  75                  80

His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser
                85                  90                  95

Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu
            100                 105                 110

Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val
        115                 120                 125

Gln Met Phe Ile Asn Thr Ser
    130                 135


<210>  55
<211>  489
<212>  DNA
<213>  ˹

<220>
<223>  mIL-15

<400>  55
atgaaaattt tgaaaccata tatgaggaat acatccatct cgtgctactt gtgtttcctt     60

ctaaacagtc actttttaac tgaggctggc attcatgtct tcattttggg ctgtgtcagt    120

gtaggtctcc ctaaaacaga ggccaactgg atagatgtaa gatatgacct ggagaaaatt    180

gaaagcctta ttcaatctat tcatattgac accactttat acactgacag tgactttcat    240

cccagttgca aagttactgc aatgaactgc tttctcctgg aattgcaggt tattttacat    300

gagtacagta acatgactct taatgaaaca gtaagaaacg tgctctacct tgcaaacagc    360

actctgtctt ctaacaagaa tgtagcagaa tctggctgca aggaatgtga ggagctggag    420

gagaaaacct tcacagagtt tttgcaaagc tttatacgca ttgtccaaat gttcatcaac    480

acgtcctga                                                            489


<210>  56
<211>  162
<212>  PRT
<213>  ˹

<220>
<223>  mIL-15

<400>  56
Met Lys Ile Leu Lys Pro Tyr Met Arg Asn Thr Ser Ile Ser Cys Tyr 
                5                   10                  15

Leu Cys Phe Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His
            20                  25                  30

Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala
        35                  40                  45

Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile
    50                  55                  60

Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His
65                  70                  75                  80

Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln
                85                  90                  95

Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg
            100                 105                 110

Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val
        115                 120                 125

Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe
    130                 135                 140

Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn
145                 150                 155                 160

Thr Ser


<210>  57
<211>  489
<212>  DNA
<213>  ˹

<220>
<223>  hIL-21

<400>  57
atgagatcca gtcctggcaa catggagagg attgtcatct gtctgatggt catcttcttg     60

gggacactgg tccacaaatc aagctcccaa ggtcaagatc gccacatgat tagaatgcgt    120

caacttatag atattgttga tcagctgaaa aattatgtga atgacttggt ccctgaattt    180

ctgccagctc cagaagatgt agagacaaac tgtgagtggt cagctttttc ctgttttcag    240

aaggcccaac taaagtcagc aaatacagga aacaatgaaa ggataatcaa tgtatcaatt    300

aaaaagctga agaggaaacc accttccaca aatgcaggga gaagacagaa acacagacta    360

acatgccctt catgtgattc ttatgagaaa aaaccaccca aagaattcct agaaagattc    420

aaatcacttc tccaaaagat gattcatcag catctgtcct ctagaacaca cggaagtgaa    480

gattcctga                                                            489


<210>  58
<211>  162
<212>  PRT
<213>  ˹

<220>
<223>  hIL-21

<400>  58
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
                5                   10                  15

Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln
            20                  25                  30

Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln
        35                  40                  45

Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro
    50                  55                  60

Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln
65                  70                  75                  80

Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile
                85                  90                  95

Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala
            100                 105                 110

Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr
       115                  120                 125

Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu
    130                 135                 140

Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu
145                 150                 155                 160

Asp Ser


<210>  59
<211>  441
<212>  DNA
<213>  ˹

<220>
<223>  mIL-21

<400>  59
atggagagga cccttgtctg tctggtagtc atcttcttgg ggacagtggc ccataaatca     60

agcccccaag ggccagatcg cctcctgatt agacttcgtc accttattga cattgttgaa    120

cagctgaaaa tctatgaaaa tgacttggat cctgaacttc tatcagctcc acaagatgta    180

aaggggcact gtgagcatgc agcttttgcc tgttttcaga aggccaaact caagccatca    240

aaccctggaa acaataagac attcatcatt gacctcgtgg cccagctcag gaggaggctg    300

cctgccagga ggggaggaaa gaaacagaag cacatagcta aatgcccttc ctgtgattcg    360

tatgagaaaa ggacacccaa agaattccta gaaagactaa aatggctcct tcaaaagatg    420

attcatcagc atctctccta g                                              441


<210>  60
<211>  146
<212>  PRT
<213>  ˹

<220>
<223>  mIL-21

<400>  60
Met Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val 
                5                   10                  15

Ala His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu
            20                  25                  30

Arg His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp
        35                  40                  45

Leu Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys
    50                  55                  60

Glu His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser
65                  70                  75                  80

Asn Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu
                85                  90                  95

Arg Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile
            100                 105                 110

Ala Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu 
        115                 120                 125

Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140

Leu Ser
145


<210>  61
<211>  468
<212>  DNA
<213>  ˹

<220>
<223>  hIL-17

<400>  61
atgactcctg ggaagacctc attggtgtca ctgctactgc tgctgagcct ggaggccata     60

gtgaaggcag gaatcacaat cccacgaaat ccaggatgcc caaattctga ggacaagaac    120

ttcccccgga ctgtgatggt caacctgaac atccataacc ggaataccaa taccaatccc    180

aaaaggtcct cagattacta caaccgatcc acctcacctt ggaatctcca ccgcaatgag    240

gaccctgaga gatatccctc tgtgatctgg gaggcaaagt gccgccactt gggctgcatc    300

aacgctgatg ggaacgtgga ctaccacatg aactctgtcc ccatccagca agagatcctg    360

gtcctgcgca gggagcctcc acactgcccc aactccttcc ggctggagaa gatactggtg    420

tccgtgggct gcacctgtgt caccccgatt gtccaccatg tggcctaa                 468


<210>  62
<211>  155
<212>  DNA
<213>  ˹

<220>
<223>  hIL-17

<400>  62
Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
                5                   10                  15

Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly
            20                  25                  30

Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn
        35                  40                  45

Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser
    50                  55                  60

Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu
65                  70                  75                  80

Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His
                85                  90                  95

Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser
            100                 105                 110

Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His
        115                 120                 125

Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys
    130                 135                 140

Thr Cys Val Thr Pro Ile Val His His Val Ala
145                 150                 155


<210>  63
<211>  477
<212>  DNA
<213>  ˹

<220>
<223>  mIL-17

<400>  63
atgagtccag ggagagcttc atctgtgtct ctgatgctgt tgctgctgct gagcctggcg     60

gctacagtga aggcagcagc gatcatccct caaagctcag cgtgtccaaa cactgaggcc    120

aaggacttcc tccagaatgt gaaggtcaac ctcaaagtct ttaactccct tggcgcaaaa    180

gtgagctcca gaaggccctc agactacctc aaccgttcca cgtcaccctg gactctccac    240

cgcaatgaag accctgatag atatccctct gtgatctggg aagctcagtg ccgccaccag    300

cgctgtgtca atgcggaggg aaagctggac caccacatga attctgttct catccagcaa    360

gagatcctgg tcctgaagag ggagcctgag agctgcccct tcactttcag ggtcgagaag    420

atgctggtgg gtgtgggctg cacctgcgtg gcctcgattg tccgccaggc agcctaa       477


<210>  64
<211>  158
<212>  PRT
<213>  ˹

<220>
<223>  mIL-17

<400>  64
Met Ser Pro Gly Arg Ala Ser Ser Val Ser Leu Met Leu Leu Leu Leu 
                5                   10                  15

Leu Ser Leu Ala Ala Thr Val Lys Ala Ala Ala Ile Ile Pro Gln Ser
            20                  25                  30

Ser Ala Cys Pro Asn Thr Glu Ala Lys Asp Phe Leu Gln Asn Val Lys
        35                  40                  45

Val Asn Leu Lys Val Phe Asn Ser Leu Gly Ala Lys Val Ser Ser Arg
    50                  55                  60

Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu His
65                  70                  75                  80

Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln
                85                  90                  95
     
Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His
            100                 105                 110

Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu
        115                 120                 125

Pro Glu Ser Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly
    130                 135                 140

Val Gly Cys Thr Cys Val Ala Ser Ile Val Arg Gln Ala Ala
145                 150                 155


<210>  65
<211>  582
<212>  DNA
<213>  ˹

<220>
<223>  hIL-18

<400>  65
atggctgctg aaccagtaga agacaattgc atcaactttg tggcaatgaa atttattgac     60

aatacgcttt actttatagc tgaagatgat gaaaacctgg aatcagatta ctttggcaag    120

cttgaatcta aattatcagt cataagaaat ttgaatgacc aagttctctt cattgaccaa    180

ggaaatcggc ctctatttga agatatgact gattctgact gtagagataa tgcaccccgg    240

accatattta ttataagtat gtataaagat agccagccta gaggtatggc tgtaactatc    300

tctgtgaagt gtgagaaaat ttcaactctc tcctgtgaga acaaaattat ttcctttaag    360

gaaatgaatc ctcctgataa catcaaggat acaaaaagtg acatcatatt ctttcagaga    420

agtgtcccag gacatgataa taagatgcaa tttgaatctt catcatacga aggatacttt    480

ctagcttgtg aaaaagagag agaccttttt aaactcattt tgaaaaaaga ggatgaattg    540

ggggatagat ctataatgtt cactgttcaa aacgaagact ag                       582


<210>  66
<211>  193
<212>  PRT
<213>  ˹

<220>
<223>  hIL-18

<400>  66
Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
                5                   10                  15

Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn
            20                  25                  30

Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile
        35                  40                  45

Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro
    50                  55                  60

Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg
65                  70                  75                  80

Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met
                85                  90                  95

Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys
            100                 105                 110

Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile
        115                 120                 125

Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly
    130                 135                 140

His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe
145                 150                 155                 160

Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys
                165                 170                 175

Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu
            180                 185                 190
Asp


<210>  67
<211>  579
<212>  DNA
<213>  ˹

<220>
<223>  mIL-18

<400>  67
atggctgcca tgtcagaaga ctcttgcgtc aacttcaagg aaatgatgtt tattgacaac     60

acgctttact ttatacctga agaaaatgga gacctggaat cagacaactt tggccgactt    120

cactgtacaa ccgcagtaat acggaatata aatgaccaag ttctcttcgt tgacaaaaga    180

cagcctgtgt tcgaggatat gactgatatt gatcaaagtg ccagtgaacc ccagaccaga    240

ctgataatat acatgtacaa agacagtgaa gtaagaggac tggctgtgac cctctctgtg    300

aaggatagta aaatgtctac cctctcctgt aagaacaaga tcatttcctt tgaggaaatg    360

gatccacctg aaaatattga tgatatacaa agtgatctca tattctttca gaaacgtgtt    420

ccaggacaca acaagatgga gtttgaatct tcactgtatg aaggacactt tcttgcttgc    480

caaaaggaag atgatgcttt caaactcatt ctgaaaaaaa aggatgaaaa tggggataaa    540

tctgtaatgt tcactctcac taacttacat caaagttag                           579


<210>  68
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  mIL-18

<400>  68
Met Ala Ala Met Ser Glu Asp Ser Cys Val Asn Phe Lys Glu Met Met
                5                   10                  15

Phe Ile Asp Asn Thr Leu Tyr Phe Ile Pro Glu Glu Asn Gly Asp Leu
            20                  25                  30

Glu Ser Asp Asn Phe Gly Arg Leu His Cys Thr Thr Ala Val Ile Arg
        35                  40                  45

Asn Ile Asn Asp Gln Val Leu Phe Val Asp Lys Arg Gln Pro Val Phe
    50                  55                  60

Glu Asp Met Thr Asp Ile Asp Gln Ser Ala Ser Glu Pro Gln Thr Arg
65                  70                  75                  80

Leu Ile Ile Tyr Met Tyr Lys Asp Ser Glu Val Arg Gly Leu Ala Val
                85                  90                  95

Thr Leu Ser Val Lys Asp Ser Lys Met Ser Thr Leu Ser Cys Lys Asn
            100                 105                 110

Lys Ile Ile Ser Phe Glu Glu Met Asp Pro Pro Glu Asn Ile Asp Asp
        115                 120                 125

Ile Gln Ser Asp Leu Ile Phe Phe Gln Lys Arg Val Pro Gly His Asn
    130                 135                 140

Lys Met Glu Phe Glu Ser Ser Leu Tyr Glu Gly His Phe Leu Ala Cys
145                 150                 155                 160

Gln Lys Glu Asp Asp Ala Phe Lys Leu Ile Leu Lys Lys Lys Asp Glu
                165                 170                 175

Asn Gly Asp Lys Ser Val Met Phe Thr Leu Thr Asn Leu His Gln Ser
            180                 185                 190


<210>  69
<211>  570
<212>  DNA
<213>  ˹

<220>
<223>  hIL-23

<400>  69
atgctgggga gcagagctgt aatgctgctg ttgctgctgc cctggacagc tcagggcaga     60

gctgtgcctg ggggcagcag ccctgcctgg actcagtgcc agcagctttc acagaagctc    120

tgcacactgg cctggagtgc acatccacta gtgggacaca tggatctaag agaagaggga    180

gatgaagaga ctacaaatga tgttccccat atccagtgtg gagatggctg tgacccccaa    240

ggactcaggg acaacagtca gttctgcttg caaaggatcc accagggtct gattttttat    300

gagaagctgc taggatcgga tattttcaca ggggagcctt ctctgctccc tgatagccct    360

gtggcgcagc ttcatgcctc cctactgggc ctcagccaac tcctgcagcc tgagggtcac    420

cactgggaga ctcagcagat tccaagcctc agtcccagcc agccatggca gcgtctcctt    480

ctccgcttca aaatccttcg cagcctccag gcctttgtgg ctgtagccgc ccgggtcttt    540

gcccatggag cagcaaccct gagtccctaa                                     570


<210>  70
<211>  189
<212>  PRT
<213>  ˹

<220>
<223>  hIL-23

<400>  70
Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr
                5                   10                  15

Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln
            20                  25                  30

Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His
        35                  40                  45

Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr
    50                  55                  60

Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln
65                  70                  75                  80

Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly
                85                  90                  95

Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu
            100                 105                 110

Pro Ser Leu Leu Pro Asp Ser Pro Val Ala Gln Leu His Ala Ser Leu
        115                 120                 125

Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr
    130                 135                 140

Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu
145                 150                 155                 160

Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala
                165                 170                 175

Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro
            180                 185


<210>  71
<211>  591
<212>  DNA
<213>  ˹

<220>
<223>  mIL-23

<400>  71
atgctggatt gcagagcagt aataatgcta tggctgttgc cctgggtcac tcagggcctg     60

gctgtgccta ggagtagcag tcctgactgg gctcagtgcc agcagctctc tcggaatctc    120

tgcatgctag cctggaacgc acatgcacca gcgggacata tgaatctact aagagaagaa    180

gaggatgaag agactaaaaa taatgtgccc cgtatccagt gtgaagatgg ttgtgaccca    240

caaggactca aggacaacag ccagttctgc ttgcaaagga tccgccaagg tctggctttt    300

tataagcacc tgcttgactc tgacatcttc aaaggggagc ctgctctact ccctgatagc    360

cccatggagc aacttcacac ctccctacta ggactcagcc aactcctcca gccagaggat    420

cacccccggg agacccaaca gatgcccagc ctgagttcta gtcagcagtg gcagcgcccc    480

cttctccgtt ccaagatcct tcgaagcctc caggcctttt tggccatagc tgcccgggtc    540

tttgcccacg gagcagcaac tctgactgag cccttagtgc caacagctta a             591


<210>  72
<211>  196
<212>  PRT
<213>  ˹

<220>
<223>  mIL-23

<400>  72
Met Leu Asp Cys Arg Ala Val Ile Met Leu Trp Leu Leu Pro Trp Val 
                5                   10                  15

Thr Gln Gly Leu Ala Val Pro Arg Ser Ser Ser Pro Asp Trp Ala Gln
            20                  25                  30

Cys Gln Gln Leu Ser Arg Asn Leu Cys Met Leu Ala Trp Asn Ala His
        35                  40                  45

Ala Pro Ala Gly His Met Asn Leu Leu Arg Glu Glu Glu Asp Glu Glu
    50                  55                  60

Thr Lys Asn Asn Val Pro Arg Ile Gln Cys Glu Asp Gly Cys Asp Pro
65                  70                  75                  80

Gln Gly Leu Lys Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile Arg Gln
                85                  90                  95

Gly Leu Ala Phe Tyr Lys His Leu Leu Asp Ser Asp Ile Phe Lys Gly
            100                 105                 110

Glu Pro Ala Leu Leu Pro Asp Ser Pro Met Glu Gln Leu His Thr Ser
        115                 120                 125

Leu Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Asp His Pro Arg Glu
    130                 135                 140

Thr Gln Gln Met Pro Ser Leu Ser Ser Ser Gln Gln Trp Gln Arg Pro
145                 150                 155                 160

Leu Leu Arg Ser Lys Ile Leu Arg Ser Leu Gln Ala Phe Leu Ala Ile
                165                 170                 175

Ala Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Thr Glu Pro Leu
            180                 185                 190

Val Pro Thr Ala
        195


<210>  73
<211>  813
<212>  DNA
<213>  ˹

<220>
<223>  hIL-33

<400>  73
atgaagccta aaatgaagta ttcaaccaac aaaatttcca cagcaaagtg gaagaacaca     60

gcaagcaaag ccttgtgttt caagctggga aaatcccaac agaaggccaa agaagtttgc    120

cccatgtact ttatgaagct ccgctctggc cttatgataa aaaaggaggc ctgttacttt    180

aggagagaaa ccaccaaaag gccttcactg aaaacaggta gaaagcacaa aagacatctg    240

gtactcgctg cctgtcaaca gcagtctact gtggagtgct ttgcctttgg tatatcaggg    300

gtccagaaat atactagagc acttcatgat tcaagtatca caggaatttc acctattaca    360

gagtatcttg cttctctaag cacatacaat gatcaatcca ttacttttgc tttggaggat    420

gaaagttatg agatatatgt tgaagacttg aaaaaagatg aaaagaaaga taaggtgtta    480

ctgagttact atgagtctca acacccctca aatgaatcag gtgacggtgt tgatggtaag    540

atgttaatgg taaccctgag tcctacaaaa gacttctggt tgcatgccaa caacaaggaa    600

cactctgtgg agctccataa gtgtgaaaaa ccactgccag accaggcctt ctttgtcctt    660

cataatatgc actccaactg tgtttcattt gaatgcaaga ctgatcctgg agtgtttata    720

ggtgtaaagg ataatcatct tgctctgatt aaagtagact cttctgagaa tttgtgtact    780

gaaaatatct tgtttaagct ctctgaaact tag                                 813


<210>  74
<211>  270
<212>  PRT
<213>  ˹

<220>
<223>  hIL-33

<400>  74
Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys
                5                   10                  15

Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser
            20                  25                  30
 
Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg
        35                  40                  45

Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr
    50                  55                  60

Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu
65                  70                  75                  80

Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe
                85                  90                  95

Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser
            100                 105                 110

Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr
        115                 120                 125

Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu
    130                 135                 140

Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu
145                 150                 155                 160

Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly
                165                 170                 175

Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe
            180                 185                 190

Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys
        195                 200                 205

Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His
    210                 215                 220

Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile
225                 230                 235                 240

Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu
                245                 250                 255

Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr
            260                 265                 270

<210>  75
<211>  801
<212>  DNA
<213>  ˹

<220>
<223>  mIL-33

<400>  75
atgagaccta gaatgaagta ttccaactcc aagatttccc cggcaaagtt cagcagcacc     60

gcaggcgaag ccctggtccc gccttgcaaa ataagaagat cccaacagaa gaccaaagaa    120

ttctgccatg tctactgcat gagactccgt tctggcctca ccataagaaa ggagactagt    180

tattttagga aagaacccac gaaaagatat tcactaaaat cgggtaccaa gcatgaagag    240

aacttctctg cctatccacg ggattctagg aagagatcct tgcttggcag tatccaagca    300

tttgctgcgt ctgttgacac attgagcatc caaggaactt cacttttaac acagtctcct    360


gcctccctga gtacatacaa tgaccaatct gttagttttg ttttggagaa tggatgttat    420

gtgatcaatg ttgacgactc tggaaaagac caagagcaag accaggtgct actacgctac    480

tatgagtctc cctgtcctgc aagtcaatca ggcgacggtg tggatgggaa gaagctgatg    540 

gtgaacatga gtcccatcaa agacacagac atctggctgc atgccaacga caaggactac    600

tccgtggagc ttcaaagggg tgacgtctcg cctccggaac aggccttctt cgtccttcac    660

aaaaagtcct cggactttgt ttcatttgaa tgcaagaatc ttcctggcac ttacatagga    720

gtaaaagata accagctggc tctagtggag gagaaagatg agagctgcaa caatattatg    780

tttaagctct cgaaaatcta a                                              801


<210>  76
<211>  266
<212>  PRT
<213>  ˹

<220>
<223>  mIL-33

<400>  76
Met Arg Pro Arg Met Lys Tyr Ser Asn Ser Lys Ile Ser Pro Ala Lys
                5                   10                  15

Phe Ser Ser Thr Ala Gly Glu Ala Leu Val Pro Pro Cys Lys Ile Arg
            20                  25                  30 

Arg Ser Gln Gln Lys Thr Lys Glu Phe Cys His Val Tyr Cys Met Arg
        35                  40                  45

Leu Arg Ser Gly Leu Thr Ile Arg Lys Glu Thr Ser Tyr Phe Arg Lys
    50                  55                  60

Glu Pro Thr Lys Arg Tyr Ser Leu Lys Ser Gly Thr Lys His Glu Glu
65                  70                  75                  80

Asn Phe Ser Ala Tyr Pro Arg Asp Ser Arg Lys Arg Ser Leu Leu Gly
                85                  90                  95

Ser Ile Gln Ala Phe Ala Ala Ser Val Asp Thr Leu Ser Ile Gln Gly
            100                 105                 110

Thr Ser Leu Leu Thr Gln Ser Pro Ala Ser Leu Ser Thr Tyr Asn Asp
        115                 120                 125

Gln Ser Val Ser Phe Val Leu Glu Asn Gly Cys Tyr Val Ile Asn Val
    130                 135                 140

Asp Asp Ser Gly Lys Asp Gln Glu Gln Asp Gln Val Leu Leu Arg Tyr
145                 150                 155                 160

Tyr Glu Ser Pro Cys Pro Ala Ser Gln Ser Gly Asp Gly Val Asp Gly
                165                 170                 175

Lys Lys Leu Met Val Asn Met Ser Pro Ile Lys Asp Thr Asp Ile Trp
            180                 185                 190

Leu His Ala Asn Asp Lys Asp Tyr Ser Val Glu Leu Gln Arg Gly Asp
        195                 200                 205

Val Ser Pro Pro Glu Gln Ala Phe Phe Val Leu His Lys Lys Ser Ser
    210                 215                 220

Asp Phe Val Ser Phe Glu Cys Lys Asn Leu Pro Gly Thr Tyr Ile Gly
225                 230                 235                 240

Val Lys Asp Asn Gln Leu Ala Leu Val Glu Glu Lys Asp Glu Ser Cys
                245                 250                 255

Asn Asn Ile Met Phe Lys Leu Ser Lys Ile
            260                 265


<210>  77
<211>  279
<212>  DNA
<213>  ˹

<220>
<223>  hCCL3

<400>  77
atgcaggtct ccactgctgc ccttgctgtc ctcctctgca ccatggctct ctgcaaccag     60

ttctctgcat cacttgctgc tgacacgccg accgcctgct gcttcagcta cacctcccgg    120

cagattccac agaatttcat agctgactac tttgagacga gcagccagtg ctccaagccc    180

ggtgtcatct tcctaaccaa gcgaagccgg caggtctgtg ctgaccccag tgaggagtgg    240

gtccagaaat atgtcagcga cctagagctg agtgcctga                           279


<210>  78
<211>  92
<212>  PRT
<213>  ˹

<220>
<223>  hCCL3

<400>  78
Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala
                5                   10                  15

Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala
            20                  25                  30

Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala
        35                  40                  45

Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe
    50                  55                  60

Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp
65                  70                  75                  80

Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala
                85                  90


<210>  79
<211>  279
<212>  DNA
<213>  ˹

<220>
<223>  mCCL3

<400>  79
atgaaggtct ccaccactgc ccttgctgtt cttctctgta ccatgacact ctgcaaccaa     60

gtcttctcag cgccatatgg agctgacacc ccgactgcct gctgcttctc ctacagccgg    120

aagattccac gccaattcat cgttgactat tttgaaacca gcagcctttg ctcccagcca    180

ggtgtcattt tcctgactaa gagaaaccgg cagatctgcg ctgactccaa agagacctgg    240

gtccaagaat acatcactga cctggaactg aatgcctga                           279


<210>  80
<211>  92
<212>  PRT
<213>  ˹

<220>
<223>  mCCL3

<400>  80
Met Lys Val Ser Thr Thr Ala Leu Ala Val Leu Leu Cys Thr Met Thr
                5                   10                  15

Leu Cys Asn Gln Val Phe Ser Ala Pro Tyr Gly Ala Asp Thr Pro Thr
            20                  25                  30

Ala Cys Cys Phe Ser Tyr Ser Arg Lys Ile Pro Arg Gln Phe Ile Val
        35                  40                  45

Asp Tyr Phe Glu Thr Ser Ser Leu Cys Ser Gln Pro Gly Val Ile Phe
    50                  55                  60

Leu Thr Lys Arg Asn Arg Gln Ile Cys Ala Asp Ser Lys Glu Thr Trp
65                  70                  75                  80

Val Gln Glu Tyr Ile Thr Asp Leu Glu Leu Asn Ala
                85                  90


<210>  81
<211>  279
<212>  DNA
<213>  ˹

<220>
<223>  hCCL4

<400>  81
atgaagctct gcgtgactgt cctgtctctc ctcatgctag tagctgcctt ctgctctcca     60

gcgctctcag caccaatggg ctcagaccct cccaccgcct gctgcttttc ttacaccgcg    120

aggaagcttc ctcgcaactt tgtggtagat tactatgaga ccagcagcct ctgctcccag    180

ccagctgtgg tattccaaac caaaagaagc aagcaagtct gtgctgatcc cagtgaatcc    240 

tgggtccagg agtacgtgta tgacctggaa ctgaactga                           279


<210>  82
<211>  92
<212>  PRT
<213>  ˹

<220>
<223>  hCCL4

<400>  82
Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
                5                   10                  15

Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr
            20                  25                  30

Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val
        35                  40                  45

Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val
    50                  55                  60

Phe Gln Thr Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser
65                  70                  75                  80

Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn
                85                  90


<210>  83
<211>  279
<212>  DNA
<213>  ˹

<220>
<223>  mCCL4

<400>  83
atgaagctct gcgtgtctgc cctctctctc ctcttgctcg tggctgcctt ctgtgctcca     60

gggttctcag caccaatggg ctctgaccct cccacttcct gctgtttctc ttacacctcc    120

cggcagcttc acagaagctt tgtgatggat tactatgaga ccagcagtct ttgctccaag    180

ccagctgtgg tattcctgac caaaagaggc agacagatct gtgctaaccc cagcgagccc    240

tgggtcactg agtacatgag tgacttggag ttgaactga                           279


<210>  84
<211>  92
<212>  PRT
<213>  ˹

<220>
<223>  mCCL4

<400>  84
Met Lys Leu Cys Val Ser Ala Leu Ser Leu Leu Leu Leu Val Ala Ala
                5                   10                  15

Phe Cys Ala Pro Gly Phe Ser Ala Pro Met Gly Ser Asp Pro Pro Thr
            20                  25                  30

Ser Cys Cys Phe Ser Tyr Thr Ser Arg Gln Leu His Arg Ser Phe Val
        35                  40                  45

Met Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Lys Pro Ala Val Val 
    50                  55                  60

Phe Leu Thr Lys Arg Gly Arg Gln Ile Cys Ala Asn Pro Ser Glu Pro
65                  70                  75                  80

Trp Val Thr Glu Tyr Met Ser Asp Leu Glu Leu Asn
                85                  90


<210>  85
<211>  276
<212>  DNA
<213>  ˹

<220>
<223>  hCCL5

<400>  85
atgaaggtct ccgcggcagc cctcgctgtc atcctcattg ctactgccct ctgcgctcct     60

gcatctgcct tcccatattc ctcggacacc acaccctgct gctttgccta cattgcccgc    120

ccactgcccc gtgcccacat caaggagtat ttctacacca gtggcaagtg ctccaaccca    180

gcagtcgtct ttgtcacccg aaagaaccgc caagtgtgtg ccaacccaga gaagaaatgg    240

gttcgggagt acatcaactc tttggagatg agctag                              276


<210>  86
<211>  91
<212>  PRT
<213>  ˹

<220>
<223>  hCCL5

<400>  86
Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala
                5                   10                  15

Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro
            20                  25                  30

Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys
        35                  40                  45

Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe
    50                  55                  60

Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp
65                  70                  75                  80
         
Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser
                85                  90


<210>  87
<211>  276
<212>  DNA
<213>  ˹

<220>
<223>  mCCL5

<400>  87
atgaagatct ctgcagctgc cctcaccatc atcctcactg cagccgccct ctgcaccccc     60

gcacctgcct caccatatgg ctcggacacc actccctgct gctttgccta cctctccctc    120

gcgctgcctc gtgcccacgt caaggagtat ttctacacca gcagcaagtg ctccaatctt    180

gcagtcgtgt ttgtcactcg aaggaaccgc caagtgtgtg ccaacccaga gaagaagtgg    240

gttcaagaat acatcaacta tttggagatg agctag                              276


<210>  88
<211>  91
<212>  PRT
<213>  ˹

<220>
<223>  mCCL5

<400>  88
Met Lys Ile Ser Ala Ala Ala Leu Thr Ile Ile Leu Thr Ala Ala Ala 
                5                   10                  15

Leu Cys Thr Pro Ala Pro Ala Ser Pro Tyr Gly Ser Asp Thr Thr Pro
            20                  25                  30

Cys Cys Phe Ala Tyr Leu Ser Leu Ala Leu Pro Arg Ala His Val Lys
        35                  40                  45

Glu Tyr Phe Tyr Thr Ser Ser Lys Cys Ser Asn Leu Ala Val Val Phe
    50                  55                  60

Val Thr Arg Arg Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp
65                  70                  75                  80

Val Gln Glu Tyr Ile Asn Tyr Leu Glu Met Ser
                85                  90