                               SEQUENCE LISTING

<110> JOSLIN DIABETES CENTER, INC.
 
<120> END STAGE RENAL DISEASE BIOMARKER PANEL

<130> J103021 1070WO (0028.1)

<140>
<141>

<150> 63/197,120
<151> 2021-06-04

<150> 63/061,616
<151> 2020-08-05

<160> 33    

<170> PatentIn version 3.5

<210> 1
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210> 2
<211> 450
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro 
    450 


<210> 3
<211> 260
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210> 4
<211> 435
<212> PRT
<213> Homo sapiens

<400> 4
Met Leu Leu Pro Trp Ala Thr Ser Ala Pro Gly Leu Ala Trp Gly Pro 
1               5                   10                  15      


Leu Val Leu Gly Leu Phe Gly Leu Leu Ala Ala Ser Gln Pro Gln Ala 
            20                  25                  30          


Val Pro Pro Tyr Ala Ser Glu Asn Gln Thr Cys Arg Asp Gln Glu Lys 
        35                  40                  45              


Glu Tyr Tyr Glu Pro Gln His Arg Ile Cys Cys Ser Arg Cys Pro Pro 
    50                  55                  60                  


Gly Thr Tyr Val Ser Ala Lys Cys Ser Arg Ile Arg Asp Thr Val Cys 
65                  70                  75                  80  


Ala Thr Cys Ala Glu Asn Ser Tyr Asn Glu His Trp Asn Tyr Leu Thr 
                85                  90                  95      


Ile Cys Gln Leu Cys Arg Pro Cys Asp Pro Val Met Gly Leu Glu Glu 
            100                 105                 110         


Ile Ala Pro Cys Thr Ser Lys Arg Lys Thr Gln Cys Arg Cys Gln Pro 
        115                 120                 125             


Gly Met Phe Cys Ala Ala Trp Ala Leu Glu Cys Thr His Cys Glu Leu 
    130                 135                 140                 


Leu Ser Asp Cys Pro Pro Gly Thr Glu Ala Glu Leu Lys Asp Glu Val 
145                 150                 155                 160 


Gly Lys Gly Asn Asn His Cys Val Pro Cys Lys Ala Gly His Phe Gln 
                165                 170                 175     


Asn Thr Ser Ser Pro Ser Ala Arg Cys Gln Pro His Thr Arg Cys Glu 
            180                 185                 190         


Asn Gln Gly Leu Val Glu Ala Ala Pro Gly Thr Ala Gln Ser Asp Thr 
        195                 200                 205             


Thr Cys Lys Asn Pro Leu Glu Pro Leu Pro Pro Glu Met Ser Gly Thr 
    210                 215                 220                 


Met Leu Met Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu 
225                 230                 235                 240 


Ala Thr Val Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg 
                245                 250                 255     


Lys Leu Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn 
            260                 265                 270         


Pro Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro 
        275                 280                 285             


Asp Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val 
    290                 295                 300                 


Ser Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln 
305                 310                 315                 320 


Gln Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly 
                325                 330                 335     


Glu Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly 
            340                 345                 350         


Gly Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val 
        355                 360                 365             


Leu Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro 
    370                 375                 380                 


Pro Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser 
385                 390                 395                 400 


Thr Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu 
                405                 410                 415     


His Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile 
            420                 425                 430         


Thr His Asp 
        435 


<210> 5
<211> 300
<212> PRT
<213> Homo sapiens

<400> 5
Met Arg Ala Leu Glu Gly Pro Gly Leu Ser Leu Leu Cys Leu Val Leu 
1               5                   10                  15      


Ala Leu Pro Ala Leu Leu Pro Val Pro Ala Val Arg Gly Val Ala Glu 
            20                  25                  30          


Thr Pro Thr Tyr Pro Trp Arg Asp Ala Glu Thr Gly Glu Arg Leu Val 
        35                  40                  45              


Cys Ala Gln Cys Pro Pro Gly Thr Phe Val Gln Arg Pro Cys Arg Arg 
    50                  55                  60                  


Asp Ser Pro Thr Thr Cys Gly Pro Cys Pro Pro Arg His Tyr Thr Gln 
65                  70                  75                  80  


Phe Trp Asn Tyr Leu Glu Arg Cys Arg Tyr Cys Asn Val Leu Cys Gly 
                85                  90                  95      


Glu Arg Glu Glu Glu Ala Arg Ala Cys His Ala Thr His Asn Arg Ala 
            100                 105                 110         


Cys Arg Cys Arg Thr Gly Phe Phe Ala His Ala Gly Phe Cys Leu Glu 
        115                 120                 125             


His Ala Ser Cys Pro Pro Gly Ala Gly Val Ile Ala Pro Gly Thr Pro 
    130                 135                 140                 


Ser Gln Asn Thr Gln Cys Gln Pro Cys Pro Pro Gly Thr Phe Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Ser Ser Glu Gln Cys Gln Pro His Arg Asn Cys Thr Ala 
                165                 170                 175     


Leu Gly Leu Ala Leu Asn Val Pro Gly Ser Ser Ser His Asp Thr Leu 
            180                 185                 190         


Cys Thr Ser Cys Thr Gly Phe Pro Leu Ser Thr Arg Val Pro Gly Ala 
        195                 200                 205             


Glu Glu Cys Glu Arg Ala Val Ile Asp Phe Val Ala Phe Gln Asp Ile 
    210                 215                 220                 


Ser Ile Lys Arg Leu Gln Arg Leu Leu Gln Ala Leu Glu Ala Pro Glu 
225                 230                 235                 240 


Gly Trp Gly Pro Thr Pro Arg Ala Gly Arg Ala Ala Leu Gln Leu Lys 
                245                 250                 255     


Leu Arg Arg Arg Leu Thr Glu Leu Leu Gly Ala Gln Asp Gly Ala Leu 
            260                 265                 270         


Leu Val Arg Leu Leu Gln Ala Leu Arg Val Ala Arg Met Pro Gly Leu 
        275                 280                 285             


Glu Arg Ser Val Arg Glu Arg Phe Leu Pro Val His 
    290                 295                 300 


<210> 6
<211> 257
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210> 7
<211> 468
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Pro Pro Pro Ala Arg Val His Leu Gly Ala Phe Leu Ala Val 
1               5                   10                  15      


Thr Pro Asn Pro Gly Ser Ala Ala Ser Gly Thr Glu Ala Ala Ala Ala 
            20                  25                  30          


Thr Pro Ser Lys Val Trp Gly Ser Ser Ala Gly Arg Ile Glu Pro Arg 
        35                  40                  45              


Gly Gly Gly Arg Gly Ala Leu Pro Thr Ser Met Gly Gln His Gly Pro 
    50                  55                  60                  


Ser Ala Arg Ala Arg Ala Gly Arg Ala Pro Gly Pro Arg Pro Ala Arg 
65                  70                  75                  80  


Glu Ala Ser Pro Arg Leu Arg Val His Lys Thr Phe Lys Phe Val Val 
                85                  90                  95      


Val Gly Val Leu Leu Gln Val Val Pro Ser Ser Ala Ala Thr Ile Lys 
            100                 105                 110         


Leu His Asp Gln Ser Ile Gly Thr Gln Gln Trp Glu His Ser Pro Leu 
        115                 120                 125             


Gly Glu Leu Cys Pro Pro Gly Ser His Arg Ser Glu His Pro Gly Ala 
    130                 135                 140                 


Cys Asn Arg Cys Thr Glu Gly Val Gly Tyr Thr Asn Ala Ser Asn Asn 
145                 150                 155                 160 


Leu Phe Ala Cys Leu Pro Cys Thr Ala Cys Lys Ser Asp Glu Glu Glu 
                165                 170                 175     


Arg Ser Pro Cys Thr Thr Thr Arg Asn Thr Ala Cys Gln Cys Lys Pro 
            180                 185                 190         


Gly Thr Phe Arg Asn Asp Asn Ser Ala Glu Met Cys Arg Lys Cys Ser 
        195                 200                 205             


Arg Gly Cys Pro Arg Gly Met Val Lys Val Lys Asp Cys Thr Pro Trp 
    210                 215                 220                 


Ser Asp Ile Glu Cys Val His Lys Glu Ser Gly Asn Gly His Asn Ile 
225                 230                 235                 240 


Trp Val Ile Leu Val Val Thr Leu Val Val Pro Leu Leu Leu Val Ala 
                245                 250                 255     


Val Leu Ile Val Cys Cys Cys Ile Gly Ser Gly Cys Gly Gly Asp Pro 
            260                 265                 270         


Lys Cys Met Asp Arg Val Cys Phe Trp Arg Leu Gly Leu Leu Arg Gly 
        275                 280                 285             


Pro Gly Ala Glu Asp Asn Ala His Asn Glu Ile Leu Ser Asn Ala Asp 
    290                 295                 300                 


Ser Leu Ser Thr Phe Val Ser Glu Gln Gln Met Glu Ser Gln Glu Pro 
305                 310                 315                 320 


Ala Asp Leu Thr Gly Val Thr Val Gln Ser Pro Gly Glu Ala Gln Cys 
                325                 330                 335     


Leu Leu Gly Pro Ala Glu Ala Glu Gly Ser Gln Arg Arg Arg Leu Leu 
            340                 345                 350         


Val Pro Ala Asn Gly Ala Asp Pro Thr Glu Thr Leu Met Leu Phe Phe 
        355                 360                 365             


Asp Lys Phe Ala Asn Ile Val Pro Phe Asp Ser Trp Asp Gln Leu Met 
    370                 375                 380                 


Arg Gln Leu Asp Leu Thr Lys Asn Glu Ile Asp Val Val Arg Ala Gly 
385                 390                 395                 400 


Thr Ala Gly Pro Gly Asp Ala Leu Tyr Ala Met Leu Met Lys Trp Val 
                405                 410                 415     


Asn Lys Thr Gly Arg Asn Ala Ser Ile His Thr Leu Leu Asp Ala Leu 
            420                 425                 430         


Glu Arg Met Glu Glu Arg His Ala Arg Glu Lys Ile Gln Asp Leu Leu 
        435                 440                 445             


Val Asp Ser Gly Lys Phe Ile Tyr Leu Glu Asp Gly Thr Gly Ser Ala 
    450                 455                 460                 


Val Ser Leu Glu 
465             


<210> 8
<211> 277
<212> PRT
<213> Homo sapiens

<400> 8
Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210> 9
<211> 283
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210> 10
<211> 297
<212> PRT
<213> Homo sapiens

<400> 10
Met Asp Cys Gln Glu Asn Glu Tyr Trp Asp Gln Trp Gly Arg Cys Val 
1               5                   10                  15      


Thr Cys Gln Arg Cys Gly Pro Gly Gln Glu Leu Ser Lys Asp Cys Gly 
            20                  25                  30          


Tyr Gly Glu Gly Gly Asp Ala Tyr Cys Thr Ala Cys Pro Pro Arg Arg 
        35                  40                  45              


Tyr Lys Ser Ser Trp Gly His His Arg Cys Gln Ser Cys Ile Thr Cys 
    50                  55                  60                  


Ala Val Ile Asn Arg Val Gln Lys Val Asn Cys Thr Ala Thr Ser Asn 
65                  70                  75                  80  


Ala Val Cys Gly Asp Cys Leu Pro Arg Phe Tyr Arg Lys Thr Arg Ile 
                85                  90                  95      


Gly Gly Leu Gln Asp Gln Glu Cys Ile Pro Cys Thr Lys Gln Thr Pro 
            100                 105                 110         


Thr Ser Glu Val Gln Cys Ala Phe Gln Leu Ser Leu Val Glu Ala Asp 
        115                 120                 125             


Thr Pro Thr Val Pro Pro Gln Glu Ala Thr Leu Val Ala Leu Val Ser 
    130                 135                 140                 


Ser Leu Leu Val Val Phe Thr Leu Ala Phe Leu Gly Leu Phe Phe Leu 
145                 150                 155                 160 


Tyr Cys Lys Gln Phe Phe Asn Arg His Cys Gln Arg Gly Gly Leu Leu 
                165                 170                 175     


Gln Phe Glu Ala Asp Lys Thr Ala Lys Glu Glu Ser Leu Phe Pro Val 
            180                 185                 190         


Pro Pro Ser Lys Glu Thr Ser Ala Glu Ser Gln Val Ser Glu Asn Ile 
        195                 200                 205             


Phe Gln Thr Gln Pro Leu Asn Pro Ile Leu Glu Asp Asp Cys Ser Ser 
    210                 215                 220                 


Thr Ser Gly Phe Pro Thr Gln Glu Ser Phe Thr Met Ala Ser Cys Thr 
225                 230                 235                 240 


Ser Glu Ser His Ser His Trp Val His Ser Pro Ile Glu Cys Thr Glu 
                245                 250                 255     


Leu Asp Leu Gln Lys Phe Ser Ser Ser Ala Ser Tyr Thr Gly Ala Glu 
            260                 265                 270         


Thr Leu Gly Gly Asn Thr Val Glu Ser Thr Gly Asp Arg Leu Glu Leu 
        275                 280                 285             


Asn Val Pro Phe Glu Val Pro Ser Pro 
    290                 295         


<210> 11
<211> 430
<212> PRT
<213> Homo sapiens

<400> 11
Met Lys Pro Ser Leu Leu Cys Arg Pro Leu Ser Cys Phe Leu Met Leu 
1               5                   10                  15      


Leu Pro Trp Pro Leu Ala Thr Leu Thr Ser Thr Thr Leu Trp Gln Cys 
            20                  25                  30          


Pro Pro Gly Glu Glu Pro Asp Leu Asp Pro Gly Gln Gly Thr Leu Cys 
        35                  40                  45              


Arg Pro Cys Pro Pro Gly Thr Phe Ser Ala Ala Trp Gly Ser Ser Pro 
    50                  55                  60                  


Cys Gln Pro His Ala Arg Cys Ser Leu Trp Arg Arg Leu Glu Ala Gln 
65                  70                  75                  80  


Val Gly Met Ala Thr Arg Asp Thr Leu Cys Gly Asp Cys Trp Pro Gly 
                85                  90                  95      


Trp Phe Gly Pro Trp Gly Val Pro Arg Val Pro Cys Gln Pro Cys Ser 
            100                 105                 110         


Trp Ala Pro Leu Gly Thr His Gly Cys Asp Glu Trp Gly Arg Arg Ala 
        115                 120                 125             


Arg Arg Gly Val Glu Val Ala Ala Gly Ala Ser Ser Gly Gly Glu Thr 
    130                 135                 140                 


Arg Gln Pro Gly Asn Gly Thr Arg Ala Gly Gly Pro Glu Glu Thr Ala 
145                 150                 155                 160 


Ala Gln Tyr Ala Val Ile Ala Ile Val Pro Val Phe Cys Leu Met Gly 
                165                 170                 175     


Leu Leu Gly Ile Leu Val Cys Asn Leu Leu Lys Arg Lys Gly Tyr His 
            180                 185                 190         


Cys Thr Ala His Lys Glu Val Gly Pro Gly Pro Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Ile Asn Pro Ala Tyr Arg Thr Glu Asp Ala Asn Glu Asp Thr Ile 
    210                 215                 220                 


Gly Val Leu Val Arg Leu Ile Thr Glu Lys Lys Glu Asn Ala Ala Ala 
225                 230                 235                 240 


Leu Glu Glu Leu Leu Lys Glu Tyr His Ser Lys Gln Leu Val Gln Thr 
                245                 250                 255     


Ser His Arg Pro Val Ser Lys Leu Pro Pro Ala Pro Pro Asn Val Pro 
            260                 265                 270         


His Ile Cys Pro His Arg His His Leu His Thr Val Gln Gly Leu Ala 
        275                 280                 285             


Ser Leu Ser Gly Pro Cys Cys Ser Arg Cys Ser Gln Lys Lys Trp Pro 
    290                 295                 300                 


Glu Val Leu Leu Ser Pro Glu Ala Val Ala Ala Thr Thr Pro Val Pro 
305                 310                 315                 320 


Ser Leu Leu Pro Asn Pro Thr Arg Val Pro Lys Ala Gly Ala Lys Ala 
                325                 330                 335     


Gly Arg Gln Gly Glu Ile Thr Ile Leu Ser Val Gly Arg Phe Arg Val 
            340                 345                 350         


Ala Arg Ile Pro Glu Gln Arg Thr Ser Ser Met Val Ser Glu Val Lys 
        355                 360                 365             


Thr Ile Thr Glu Ala Gly Pro Ser Trp Gly Asp Leu Pro Asp Ser Pro 
    370                 375                 380                 


Gln Pro Gly Leu Pro Pro Glu Gln Gln Ala Leu Leu Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Arg Thr Lys Trp Leu Lys Pro Pro Ala Glu Asn Lys Ala Glu Glu 
                405                 410                 415     


Asn Arg Tyr Val Val Arg Leu Ser Glu Ser Asn Leu Val Ile 
            420                 425                 430 


<210> 12
<211> 181
<212> PRT
<213> Homo sapiens

<400> 12
Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala Leu 
            180     


<210> 13
<211> 569
<212> PRT
<213> Homo sapiens

<400> 13
Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210> 14
<211> 723
<212> PRT
<213> Homo sapiens

<400> 14
Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210> 15
<211> 382
<212> PRT
<213> Homo sapiens

<400> 15
Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Ala Ser Asp Leu 
            20                  25                  30          


Asp Leu Arg Gly Gly Gln Pro Val Cys Arg Gly Gly Thr Gln Arg Pro 
        35                  40                  45              


Cys Tyr Lys Val Ile Tyr Phe His Asp Thr Ser Arg Arg Leu Asn Phe 
    50                  55                  60                  


Glu Glu Ala Lys Glu Ala Cys Arg Arg Asp Gly Gly Gln Leu Val Ser 
65                  70                  75                  80  


Ile Glu Ser Glu Asp Glu Gln Lys Leu Ile Glu Lys Phe Ile Glu Asn 
                85                  90                  95      


Leu Leu Pro Ser Asp Gly Asp Phe Trp Ile Gly Leu Arg Arg Arg Glu 
            100                 105                 110         


Glu Lys Gln Ser Asn Ser Thr Ala Cys Gln Asp Leu Tyr Ala Trp Thr 
        115                 120                 125             


Asp Gly Ser Ile Ser Gln Phe Arg Asn Trp Tyr Val Asp Glu Pro Ser 
    130                 135                 140                 


Cys Gly Ser Glu Val Cys Val Val Met Tyr His Gln Pro Ser Ala Pro 
145                 150                 155                 160 


Ala Gly Ile Gly Gly Pro Tyr Met Phe Gln Trp Asn Asp Asp Arg Cys 
                165                 170                 175     


Asn Met Lys Asn Asn Phe Ile Cys Lys Tyr Ser Asp Glu Lys Pro Ala 
            180                 185                 190         


Val Pro Ser Arg Glu Ala Glu Gly Glu Glu Thr Glu Leu Thr Thr Pro 
        195                 200                 205             


Val Leu Pro Glu Glu Thr Gln Glu Glu Asp Ala Lys Lys Thr Phe Lys 
    210                 215                 220                 


Glu Ser Arg Glu Ala Ala Leu Asn Leu Ala Tyr Ile Leu Ile Pro Ser 
225                 230                 235                 240 


Ile Pro Leu Leu Leu Leu Leu Val Val Thr Thr Val Val Cys Trp Val 
                245                 250                 255     


Trp Ile Cys Arg Lys Arg Lys Arg Glu Gln Pro Asp Pro Ser Thr Lys 
            260                 265                 270         


Lys Gln His Thr Ile Trp Pro Ser Pro His Gln Gly Asn Ser Pro Asp 
        275                 280                 285             


Leu Glu Val Tyr Asn Val Ile Arg Lys Gln Ser Glu Ala Asp Leu Ala 
    290                 295                 300                 


Glu Thr Arg Pro Asp Leu Lys Asn Ile Ser Phe Arg Val Cys Ser Gly 
305                 310                 315                 320 


Glu Ala Thr Pro Asp Asp Met Ser Cys Asp Tyr Asp Asn Met Ala Val 
                325                 330                 335     


Asn Pro Ser Glu Ser Gly Phe Val Thr Leu Val Ser Val Glu Ser Gly 
            340                 345                 350         


Phe Val Thr Asn Asp Ile Tyr Glu Phe Ser Pro Asp Gln Met Gly Arg 
        355                 360                 365             


Ser Lys Glu Ser Gly Trp Val Glu Asn Glu Ile Tyr Gly Tyr 
    370                 375                 380         


<210> 16
<211> 267
<212> PRT
<213> Homo sapiens

<400> 16
Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu 
1               5                   10                  15      


Ala Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp 
            20                  25                  30          


Glu Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu 
        35                  40                  45              


Thr Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys 
    50                  55                  60                  


Phe Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser Arg Val Ile Glu 
65                  70                  75                  80  


Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser 
                85                  90                  95      


Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg 
            100                 105                 110         


Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu 
        115                 120                 125             


Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe 
    130                 135                 140                 


Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg 
145                 150                 155                 160 


Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu 
                165                 170                 175     


Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe 
            180                 185                 190         


Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe 
        195                 200                 205             


Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His 
    210                 215                 220                 


Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp 
225                 230                 235                 240 


Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys 
                245                 250                 255     


Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 
            260                 265         


<210> 17
<211> 181
<212> PRT
<213> Homo sapiens

<400> 17
Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser 
        115                 120                 125             


His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser 
    130                 135                 140                 


Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly 
145                 150                 155                 160 


Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu 
                165                 170                 175     


Glu Gly Ala Glu Asp 
            180     


<210> 18
<211> 124
<212> PRT
<213> Homo sapiens

<400> 18
Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys 
            20                  25                  30          


Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu 
        35                  40                  45              


Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala 
    50                  55                  60                  


Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Asp Lys Glu Gly Ser Cys 
65                  70                  75                  80  


Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln 
                85                  90                  95      


Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn 
            100                 105                 110         


Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe 
        115                 120                 


<210> 19
<211> 201
<212> PRT
<213> Homo sapiens

<400> 19
Met Arg Leu Leu Pro Leu Leu Arg Thr Val Leu Trp Ala Ala Phe Leu 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Gly Ser Ser Leu Arg His Val Val Tyr Trp 
            20                  25                  30          


Asn Ser Ser Asn Pro Arg Leu Leu Arg Gly Asp Ala Val Val Glu Leu 
        35                  40                  45              


Gly Leu Asn Asp Tyr Leu Asp Ile Val Cys Pro His Tyr Glu Gly Pro 
    50                  55                  60                  


Gly Pro Pro Glu Gly Pro Glu Thr Phe Ala Leu Tyr Met Val Asp Trp 
65                  70                  75                  80  


Pro Gly Tyr Glu Ser Cys Gln Ala Glu Gly Pro Arg Ala Tyr Lys Arg 
                85                  90                  95      


Trp Val Cys Ser Leu Pro Phe Gly His Val Gln Phe Ser Glu Lys Ile 
            100                 105                 110         


Gln Arg Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Leu Pro Gly Glu 
        115                 120                 125             


Thr Tyr Tyr Tyr Ile Ser Val Pro Thr Pro Glu Ser Ser Gly Gln Cys 
    130                 135                 140                 


Leu Arg Leu Gln Val Ser Val Cys Cys Lys Glu Arg Lys Ser Glu Ser 
145                 150                 155                 160 


Ala His Pro Val Gly Ser Pro Gly Glu Ser Gly Thr Ser Gly Trp Arg 
                165                 170                 175     


Gly Gly Asp Thr Pro Ser Pro Leu Cys Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Ile Leu Arg Leu Leu Arg Ile Leu 
        195                 200     


<210> 20
<211> 976
<212> PRT
<213> Homo sapiens

<400> 20
Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210> 21
<211> 465
<212> PRT
<213> Homo sapiens

<400> 21
Met Phe Leu Ala Thr Leu Tyr Phe Ala Leu Pro Leu Leu Asp Leu Leu 
1               5                   10                  15      


Leu Ser Ala Glu Val Ser Gly Gly Asp Arg Leu Asp Cys Val Lys Ala 
            20                  25                  30          


Ser Asp Gln Cys Leu Lys Glu Gln Ser Cys Ser Thr Lys Tyr Arg Thr 
        35                  40                  45              


Leu Arg Gln Cys Val Ala Gly Lys Glu Thr Asn Phe Ser Leu Ala Ser 
    50                  55                  60                  


Gly Leu Glu Ala Lys Asp Glu Cys Arg Ser Ala Met Glu Ala Leu Lys 
65                  70                  75                  80  


Gln Lys Ser Leu Tyr Asn Cys Arg Cys Lys Arg Gly Met Lys Lys Glu 
                85                  90                  95      


Lys Asn Cys Leu Arg Ile Tyr Trp Ser Met Tyr Gln Ser Leu Gln Gly 
            100                 105                 110         


Asn Asp Leu Leu Glu Asp Ser Pro Tyr Glu Pro Val Asn Ser Arg Leu 
        115                 120                 125             


Ser Asp Ile Phe Arg Val Val Pro Phe Ile Ser Asp Val Phe Gln Gln 
    130                 135                 140                 


Val Glu His Ile Pro Lys Gly Asn Asn Cys Leu Asp Ala Ala Lys Ala 
145                 150                 155                 160 


Cys Asn Leu Asp Asp Ile Cys Lys Lys Tyr Arg Ser Ala Tyr Ile Thr 
                165                 170                 175     


Pro Cys Thr Thr Ser Val Ser Asn Asp Val Cys Asn Arg Arg Lys Cys 
            180                 185                 190         


His Lys Ala Leu Arg Gln Phe Phe Asp Lys Val Pro Ala Lys His Ser 
        195                 200                 205             


Tyr Gly Met Leu Phe Cys Ser Cys Arg Asp Ile Ala Cys Thr Glu Arg 
    210                 215                 220                 


Arg Arg Gln Thr Ile Val Pro Val Cys Ser Tyr Glu Glu Arg Glu Lys 
225                 230                 235                 240 


Pro Asn Cys Leu Asn Leu Gln Asp Ser Cys Lys Thr Asn Tyr Ile Cys 
                245                 250                 255     


Arg Ser Arg Leu Ala Asp Phe Phe Thr Asn Cys Gln Pro Glu Ser Arg 
            260                 265                 270         


Ser Val Ser Ser Cys Leu Lys Glu Asn Tyr Ala Asp Cys Leu Leu Ala 
        275                 280                 285             


Tyr Ser Gly Leu Ile Gly Thr Val Met Thr Pro Asn Tyr Ile Asp Ser 
    290                 295                 300                 


Ser Ser Leu Ser Val Ala Pro Trp Cys Asp Cys Ser Asn Ser Gly Asn 
305                 310                 315                 320 


Asp Leu Glu Glu Cys Leu Lys Phe Leu Asn Phe Phe Lys Asp Asn Thr 
                325                 330                 335     


Cys Leu Lys Asn Ala Ile Gln Ala Phe Gly Asn Gly Ser Asp Val Thr 
            340                 345                 350         


Val Trp Gln Pro Ala Phe Pro Val Gln Thr Thr Thr Ala Thr Thr Thr 
        355                 360                 365             


Thr Ala Leu Arg Val Lys Asn Lys Pro Leu Gly Pro Ala Gly Ser Glu 
    370                 375                 380                 


Asn Glu Ile Pro Thr His Val Leu Pro Pro Cys Ala Asn Leu Gln Ala 
385                 390                 395                 400 


Gln Lys Leu Lys Ser Asn Val Ser Gly Asn Thr His Leu Cys Ile Ser 
                405                 410                 415     


Asn Gly Asn Tyr Glu Lys Glu Gly Leu Gly Ala Ser Ser His Ile Thr 
            420                 425                 430         


Thr Lys Ser Met Ala Ala Pro Pro Ser Cys Gly Leu Ser Pro Leu Leu 
        435                 440                 445             


Val Leu Val Val Thr Ala Leu Ser Thr Leu Leu Ser Leu Thr Glu Thr 
    450                 455                 460                 


Ser 
465 


<210> 22
<211> 364
<212> PRT
<213> Homo sapiens

<400> 22
Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210> 23
<211> 117
<212> PRT
<213> Homo sapiens

<400> 23
Met Arg Ala Ser Ser Phe Leu Ile Val Val Val Phe Leu Ile Ala Gly 
1               5                   10                  15      


Thr Leu Val Leu Glu Ala Ala Val Thr Gly Val Pro Val Lys Gly Gln 
            20                  25                  30          


Asp Thr Val Lys Gly Arg Val Pro Phe Asn Gly Gln Asp Pro Val Lys 
        35                  40                  45              


Gly Gln Val Ser Val Lys Gly Gln Asp Lys Val Lys Ala Gln Glu Pro 
    50                  55                  60                  


Val Lys Gly Pro Val Ser Thr Lys Pro Gly Ser Cys Pro Ile Ile Leu 
65                  70                  75                  80  


Ile Arg Cys Ala Met Leu Asn Pro Pro Asn Arg Cys Leu Lys Asp Thr 
                85                  90                  95      


Asp Cys Pro Gly Ile Lys Lys Cys Cys Glu Gly Ser Cys Gly Met Ala 
            100                 105                 110         


Cys Phe Val Pro Gln 
        115         


<210> 24
<211> 616
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile Ala Pro 
            20                  25                  30          


Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg Cys Cys Asn 
        35                  40                  45              


Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys Thr Thr Thr Ser 
    50                  55                  60                  


Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu Tyr Leu Asp Ser Trp 
65                  70                  75                  80  


Asn Glu Glu Asp Lys Cys Leu Leu His Lys Val Cys Asp Thr Gly Lys 
                85                  90                  95      


Ala Leu Val Ala Val Val Ala Gly Asn Ser Thr Thr Pro Arg Arg Cys 
            100                 105                 110         


Ala Cys Thr Ala Gly Tyr His Trp Ser Gln Asp Cys Glu Cys Cys Arg 
        115                 120                 125             


Arg Asn Thr Glu Cys Ala Pro Gly Leu Gly Ala Gln His Pro Leu Gln 
    130                 135                 140                 


Leu Asn Lys Asp Thr Val Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser 
145                 150                 155                 160 


Asp Ala Phe Ser Ser Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr 
                165                 170                 175     


Phe Leu Gly Lys Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala 
            180                 185                 190         


Val Cys Ser Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His 
        195                 200                 205             


Val Tyr Leu Pro Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala 
    210                 215                 220                 


Leu Val Ala Ala Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys 
225                 230                 235                 240 


Ala Leu Thr Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg 
                245                 250                 255     


Leu Ser Gly Asp Lys Glu Ser Ser Gly Asp Ser Cys Val Ser Thr His 
            260                 265                 270         


Thr Ala Asn Phe Gly Gln Gln Gly Ala Cys Glu Gly Val Leu Leu Leu 
        275                 280                 285             


Thr Leu Glu Glu Lys Thr Phe Pro Glu Asp Met Cys Tyr Pro Asp Gln 
    290                 295                 300                 


Gly Gly Val Cys Gln Gly Thr Cys Val Gly Gly Gly Pro Tyr Ala Gln 
305                 310                 315                 320 


Gly Glu Asp Ala Arg Met Leu Ser Leu Val Ser Lys Thr Glu Ile Glu 
                325                 330                 335     


Glu Asp Ser Phe Arg Gln Met Pro Thr Glu Asp Glu Tyr Met Asp Arg 
            340                 345                 350         


Pro Ser Gln Pro Thr Asp Gln Leu Leu Phe Leu Thr Glu Pro Gly Ser 
        355                 360                 365             


Lys Ser Thr Pro Pro Phe Ser Glu Pro Leu Glu Val Gly Glu Asn Asp 
    370                 375                 380                 


Ser Leu Ser Gln Cys Phe Thr Gly Thr Gln Ser Thr Val Gly Ser Glu 
385                 390                 395                 400 


Ser Cys Asn Cys Thr Glu Pro Leu Cys Arg Thr Asp Trp Thr Pro Met 
                405                 410                 415     


Ser Ser Glu Asn Tyr Leu Gln Lys Glu Val Asp Ser Gly His Cys Pro 
            420                 425                 430         


His Trp Ala Ala Ser Pro Ser Pro Asn Trp Ala Asp Val Cys Thr Gly 
        435                 440                 445             


Cys Arg Asn Pro Pro Gly Glu Asp Cys Glu Pro Leu Val Gly Ser Pro 
    450                 455                 460                 


Lys Arg Gly Pro Leu Pro Gln Cys Ala Tyr Gly Met Gly Leu Pro Pro 
465                 470                 475                 480 


Glu Glu Glu Ala Ser Arg Thr Glu Ala Arg Asp Gln Pro Glu Asp Gly 
                485                 490                 495     


Ala Asp Gly Arg Leu Pro Ser Ser Ala Arg Ala Gly Ala Gly Ser Gly 
            500                 505                 510         


Ser Ser Pro Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn 
        515                 520                 525             


Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys Gly 
    530                 535                 540                 


Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly Ala Ala 
545                 550                 555                 560 


Ala Ala Ala Glu Pro Met Gly Arg Pro Val Gln Glu Glu Thr Leu Ala 
                565                 570                 575     


Arg Arg Asp Ser Phe Ala Gly Asn Gly Pro Arg Phe Pro Asp Pro Cys 
            580                 585                 590         


Gly Gly Pro Glu Gly Leu Arg Glu Pro Glu Lys Ala Ser Arg Pro Val 
        595                 600                 605             


Gln Glu Gln Gly Gly Ala Lys Ala 
    610                 615     


<210> 25
<211> 290
<212> PRT
<213> Homo sapiens

<400> 25
Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro 
145                 150                 155                 160 


Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu 
                165                 170                 175     


Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro 
            180                 185                 190         


Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu 
        195                 200                 205             


Thr Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu 
    210                 215                 220                 


Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala 
225                 230                 235                 240 


Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala 
                245                 250                 255     


Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His 
            260                 265                 270         


Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser 
        275                 280                 285             


Arg Pro 
    290 


<210> 26
<211> 129
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Thr Phe Val Leu Gly Leu Leu Ser 
                85                  90                  95      


Gly Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Ala Val Ala Leu Ile 
        115                 120                 125             


Gln 
    


<210> 27
<211> 440
<212> PRT
<213> Homo sapiens

<400> 27
Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro 
        195                 200                 205             


Cys Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val 
    210                 215                 220                 


Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val 
225                 230                 235                 240 


Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu 
                245                 250                 255     


Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu 
            260                 265                 270         


Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu 
        275                 280                 285             


Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser 
    290                 295                 300                 


Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser 
305                 310                 315                 320 


Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu 
                325                 330                 335     


Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp 
            340                 345                 350         


Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile 
        355                 360                 365             


Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr 
    370                 375                 380                 


Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His 
385                 390                 395                 400 


Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln 
                405                 410                 415     


Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu 
            420                 425                 430         


Gly Asn Ala Asp Ser Ala Met Ser 
        435                 440 


<210> 28
<211> 437
<212> PRT
<213> Homo sapiens

<400> 28
Met Gly Leu Arg Ala Ala Pro Ser Ser Ala Ala Ala Ala Ala Ala Glu 
1               5                   10                  15      


Val Glu Gln Arg Arg Ser Pro Gly Leu Cys Pro Pro Pro Leu Glu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Phe Ser Leu Gly Leu Leu His Ala Gly Asp Cys 
        35                  40                  45              


Gln Gln Pro Ala Gln Cys Arg Ile Gln Lys Cys Thr Thr Asp Phe Val 
    50                  55                  60                  


Ser Leu Thr Ser His Leu Asn Ser Ala Val Asp Gly Phe Asp Ser Glu 
65                  70                  75                  80  


Phe Cys Lys Ala Leu Arg Ala Tyr Ala Gly Cys Thr Gln Arg Thr Ser 
                85                  90                  95      


Lys Ala Cys Arg Gly Asn Leu Val Tyr His Ser Ala Val Leu Gly Ile 
            100                 105                 110         


Ser Asp Leu Met Ser Gln Arg Asn Cys Ser Lys Asp Gly Pro Thr Ser 
        115                 120                 125             


Ser Thr Asn Pro Glu Val Thr His Asp Pro Cys Asn Tyr His Ser His 
    130                 135                 140                 


Ala Gly Ala Arg Glu His Arg Arg Gly Asp Gln Asn Pro Pro Ser Tyr 
145                 150                 155                 160 


Leu Phe Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Lys Asp 
                165                 170                 175     


Asn Phe Gln Thr Cys Lys Val Glu Gly Ala Trp Pro Leu Ile Asp Asn 
            180                 185                 190         


Asn Tyr Leu Ser Val Gln Val Thr Asn Val Pro Val Val Pro Gly Ser 
        195                 200                 205             


Ser Ala Thr Ala Thr Asn Lys Ile Thr Ile Ile Phe Lys Ala His His 
    210                 215                 220                 


Glu Cys Thr Asp Gln Lys Val Tyr Gln Ala Val Thr Asp Asp Leu Pro 
225                 230                 235                 240 


Ala Ala Phe Val Asp Gly Thr Thr Ser Gly Gly Asp Ser Asp Ala Lys 
                245                 250                 255     


Ser Leu Arg Ile Val Glu Arg Glu Ser Gly His Tyr Val Glu Met His 
            260                 265                 270         


Ala Arg Tyr Ile Gly Thr Thr Val Phe Val Arg Gln Val Gly Arg Tyr 
        275                 280                 285             


Leu Thr Leu Ala Ile Arg Met Pro Glu Asp Leu Ala Met Ser Tyr Glu 
    290                 295                 300                 


Glu Ser Gln Asp Leu Gln Leu Cys Val Asn Gly Cys Pro Leu Ser Glu 
305                 310                 315                 320 


Arg Ile Asp Asp Gly Gln Gly Gln Val Ser Ala Ile Leu Gly His Ser 
                325                 330                 335     


Leu Pro Arg Thr Ser Leu Val Gln Ala Trp Pro Gly Tyr Thr Leu Glu 
            340                 345                 350         


Thr Ala Asn Thr Gln Cys His Glu Lys Met Pro Val Lys Asp Ile Tyr 
        355                 360                 365             


Phe Gln Ser Cys Val Phe Asp Leu Leu Thr Thr Gly Asp Ala Asn Phe 
    370                 375                 380                 


Thr Ala Ala Ala His Ser Ala Leu Glu Asp Val Glu Ala Leu His Pro 
385                 390                 395                 400 


Arg Lys Glu Arg Trp His Ile Phe Pro Ser Ser Gly Asn Gly Thr Pro 
                405                 410                 415     


Arg Gly Gly Ser Asp Leu Ser Val Ser Leu Gly Leu Thr Cys Leu Ile 
            420                 425                 430         


Leu Ile Val Phe Leu 
        435         


<210> 29
<211> 224
<212> PRT
<213> Homo sapiens

<400> 29
Met Val Ala Ala Val Leu Leu Gly Leu Ser Trp Leu Cys Ser Pro Leu 
1               5                   10                  15      


Gly Ala Leu Val Leu Asp Phe Asn Asn Ile Arg Ser Ser Ala Asp Leu 
            20                  25                  30          


His Gly Ala Arg Lys Gly Ser Gln Cys Leu Ser Asp Thr Asp Cys Asn 
        35                  40                  45              


Thr Arg Lys Phe Cys Leu Gln Pro Arg Asp Glu Lys Pro Phe Cys Ala 
    50                  55                  60                  


Thr Cys Arg Gly Leu Arg Arg Arg Cys Gln Arg Asp Ala Met Cys Cys 
65                  70                  75                  80  


Pro Gly Thr Leu Cys Val Asn Asp Val Cys Thr Thr Met Glu Asp Ala 
                85                  90                  95      


Thr Pro Ile Leu Glu Arg Gln Leu Asp Glu Gln Asp Gly Thr His Ala 
            100                 105                 110         


Glu Gly Thr Thr Gly His Pro Val Gln Glu Asn Gln Pro Lys Arg Lys 
        115                 120                 125             


Pro Ser Ile Lys Lys Ser Gln Gly Arg Lys Gly Gln Glu Gly Glu Ser 
    130                 135                 140                 


Cys Leu Arg Thr Phe Asp Cys Gly Pro Gly Leu Cys Cys Ala Arg His 
145                 150                 155                 160 


Phe Trp Thr Lys Ile Cys Lys Pro Val Leu Leu Glu Gly Gln Val Cys 
                165                 170                 175     


Ser Arg Arg Gly His Lys Asp Thr Ala Gln Ala Pro Glu Ile Phe Gln 
            180                 185                 190         


Arg Cys Asp Cys Gly Pro Gly Leu Leu Cys Arg Ser Gln Leu Thr Ser 
        195                 200                 205             


Asn Arg Gln His Ala Arg Leu Arg Val Cys Gln Lys Ile Glu Lys Leu 
    210                 215                 220                 


<210> 30
<211> 94
<212> PRT
<213> Homo sapiens

<400> 30
Met Lys Arg Val Leu Ser Cys Val Pro Glu Pro Thr Val Val Met Ala 
1               5                   10                  15      


Ala Arg Ala Leu Cys Met Leu Gly Leu Val Leu Ala Leu Leu Ser Ser 
            20                  25                  30          


Ser Ser Ala Glu Glu Tyr Val Gly Leu Ser Ala Asn Gln Cys Ala Val 
        35                  40                  45              


Pro Ala Lys Asp Arg Val Asp Cys Gly Tyr Pro His Val Thr Pro Lys 
    50                  55                  60                  


Glu Cys Asn Asn Arg Gly Cys Cys Phe Asp Ser Arg Ile Pro Gly Val 
65                  70                  75                  80  


Pro Trp Cys Phe Lys Pro Leu Gln Glu Ala Glu Cys Thr Phe 
                85                  90                  


<210> 31
<211> 353
<212> PRT
<213> Homo sapiens

<400> 31
Met Arg Leu Pro Arg Arg Ala Ala Leu Gly Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Pro Ala Pro Glu Ala Ala Lys Lys Pro Thr Pro Cys His 
            20                  25                  30          


Arg Cys Arg Gly Leu Val Asp Lys Phe Asn Gln Gly Met Val Asp Thr 
        35                  40                  45              


Ala Lys Lys Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Lys Thr 
    50                  55                  60                  


Leu Ser Lys Tyr Glu Ser Ser Glu Ile Arg Leu Leu Glu Ile Leu Glu 
65                  70                  75                  80  


Gly Leu Cys Glu Ser Ser Asp Phe Glu Cys Asn Gln Met Leu Glu Ala 
                85                  90                  95      


Gln Glu Glu His Leu Glu Ala Trp Trp Leu Gln Leu Lys Ser Glu Tyr 
            100                 105                 110         


Pro Asp Leu Phe Glu Trp Phe Cys Val Lys Thr Leu Lys Val Cys Cys 
        115                 120                 125             


Ser Pro Gly Thr Tyr Gly Pro Asp Cys Leu Ala Cys Gln Gly Gly Ser 
    130                 135                 140                 


Gln Arg Pro Cys Ser Gly Asn Gly His Cys Ser Gly Asp Gly Ser Arg 
145                 150                 155                 160 


Gln Gly Asp Gly Ser Cys Arg Cys His Met Gly Tyr Gln Gly Pro Leu 
                165                 170                 175     


Cys Thr Asp Cys Met Asp Gly Tyr Phe Ser Ser Leu Arg Asn Glu Thr 
            180                 185                 190         


His Ser Ile Cys Thr Ala Cys Asp Glu Ser Cys Lys Thr Cys Ser Gly 
        195                 200                 205             


Leu Thr Asn Arg Asp Cys Gly Glu Cys Glu Val Gly Trp Val Leu Asp 
    210                 215                 220                 


Glu Gly Ala Cys Val Asp Val Asp Glu Cys Ala Ala Glu Pro Pro Pro 
225                 230                 235                 240 


Cys Ser Ala Ala Gln Phe Cys Lys Asn Ala Asn Gly Ser Tyr Thr Cys 
                245                 250                 255     


Glu Glu Cys Asp Ser Ser Cys Val Gly Cys Thr Gly Glu Gly Pro Gly 
            260                 265                 270         


Asn Cys Lys Glu Cys Ile Ser Gly Tyr Ala Arg Glu His Gly Gln Cys 
        275                 280                 285             


Ala Asp Val Asp Glu Cys Ser Leu Ala Glu Lys Thr Cys Val Arg Lys 
    290                 295                 300                 


Asn Glu Asn Cys Tyr Asn Thr Pro Gly Ser Tyr Val Cys Val Cys Pro 
305                 310                 315                 320 


Asp Gly Phe Glu Glu Thr Glu Asp Ala Cys Val Pro Pro Ala Glu Ala 
                325                 330                 335     


Glu Ala Thr Glu Gly Glu Ser Pro Thr Gln Leu Pro Ser Arg Glu Asp 
            340                 345                 350         


Leu 
    


<210> 32
<211> 398
<212> PRT
<213> Homo sapiens

<400> 32
Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Asp Ser Gln 
            20                  25                  30          


Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val Val Leu 
        35                  40                  45              


Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp Ser Asn 
    50                  55                  60                  


Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu Arg Asp 
65                  70                  75                  80  


Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser Ile Ser 
                85                  90                  95      


Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys Ser Ile 
            100                 105                 110         


Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val Leu Gly 
        115                 120                 125             


Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu Arg Glu 
    130                 135                 140                 


Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys Pro Ala 
145                 150                 155                 160 


Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly Glu Pro 
                165                 170                 175     


Thr Arg Ile Gln Glu Asp Pro Asn Gly Lys Thr Phe Thr Val Ser Ser 
            180                 185                 190         


Ser Val Thr Phe Gln Val Thr Arg Glu Asp Asp Gly Ala Ser Ile Val 
        195                 200                 205             


Cys Ser Val Asn His Glu Ser Leu Lys Gly Ala Asp Arg Ser Thr Ser 
    210                 215                 220                 


Gln Arg Ile Glu Val Leu Tyr Thr Pro Thr Ala Met Ile Arg Pro Asp 
225                 230                 235                 240 


Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys Glu Gly 
                245                 250                 255     


Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu Gly Ser 
            260                 265                 270         


Val Pro Pro Leu Lys Met Thr Gln Glu Ser Ala Leu Ile Phe Pro Phe 
        275                 280                 285             


Leu Asn Lys Ser Asp Ser Gly Thr Tyr Gly Cys Thr Ala Thr Ser Asn 
    290                 295                 300                 


Met Gly Ser Tyr Lys Ala Tyr Tyr Thr Leu Asn Val Asn Asp Pro Ser 
305                 310                 315                 320 


Pro Val Pro Ser Ser Ser Ser Thr Tyr His Ala Ile Ile Gly Gly Ile 
                325                 330                 335     


Val Ala Phe Ile Val Phe Leu Leu Leu Ile Met Leu Ile Phe Leu Gly 
            340                 345                 350         


His Tyr Leu Ile Arg His Lys Gly Thr Tyr Leu Thr His Glu Ala Lys 
        355                 360                 365             


Gly Ser Asp Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
    370                 375                 380                 


Gly Gly Gln Ser Gly Gly Asp Asp Lys Lys Glu Tyr Phe Ile 
385                 390                 395             


<210> 33
<211> 906
<212> PRT
<213> Homo sapiens

<400> 33
Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765             


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780                 


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800 


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815     


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830         


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845             


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala 
    850                 855                 860                 


Lys Ser Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr 
865                 870                 875                 880 


Pro Tyr Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg 
                885                 890                 895     


Gln Ser Ala Arg Leu Trp Glu Thr Ser Ile 
            900                 905     


