
                                SEQUENCE LISTING

<110> Blenis, John
      da Silva Gomes, Ana Patricia
      

<120> METHYLMALONIC ACID AND METABOLISM THEREOF IS A CANCER
      BIOMARKER AND TARGET
  

<130> 1676.170WO1

<150> US 63/061,523       
<151> 2020-08-05  

<160> 59

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 386
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Gln Arg Glu Met Trp Arg Leu Met Ser Arg Phe Asn Ala Phe
 1               5                  10                  15
Lys Arg Thr Asn Thr Ile Leu His His Leu Arg Met Ser Lys His Thr
            20                  25                  30
Asp Ala Ala Glu Glu Val Leu Leu Glu Lys Lys Gly Cys Thr Gly Val
        35                  40                  45
Ile Thr Leu Asn Arg Pro Lys Phe Leu Asn Ala Leu Thr Leu Asn Met
    50                  55                  60
Ile Arg Gln Ile Tyr Pro Gln Leu Lys Lys Trp Glu Gln Asp Pro Glu
65                  70                  75                  80
Thr Phe Leu Ile Ile Ile Lys Gly Ala Gly Gly Lys Ala Phe Cys Ala
                85                  90                  95
Gly Gly Asp Ile Arg Val Ile Ser Glu Ala Glu Lys Ala Lys Gln Lys
            100                 105                 110
Ile Ala Pro Val Phe Phe Arg Glu Glu Tyr Met Leu Asn Asn Ala Val
        115                 120                 125
Gly Ser Cys Gln Lys Pro Tyr Val Ala Leu Ile His Gly Ile Thr Met
    130                 135                 140
Gly Gly Gly Val Gly Leu Ser Val His Gly Gln Phe Arg Val Ala Thr
145                 150                 155                 160
Glu Lys Cys Leu Phe Ala Met Pro Glu Thr Ala Ile Gly Leu Phe Pro
                165                 170                 175
Asp Val Gly Gly Gly Tyr Phe Leu Pro Arg Leu Gln Gly Lys Leu Gly
            180                 185                 190
Tyr Phe Leu Ala Leu Thr Gly Phe Arg Leu Lys Gly Arg Asp Val Tyr
        195                 200                 205
Arg Ala Gly Ile Ala Thr His Phe Val Asp Ser Glu Lys Leu Ala Met
    210                 215                 220
Leu Glu Glu Asp Leu Leu Ala Leu Lys Ser Pro Ser Lys Glu Asn Ile
225                 230                 235                 240
Ala Ser Val Leu Glu Asn Tyr His Thr Glu Ser Lys Ile Asp Arg Asp
                245                 250                 255
Lys Ser Phe Ile Leu Glu Glu His Met Asp Lys Ile Asn Ser Cys Phe
            260                 265                 270
Ser Ala Asn Thr Val Glu Glu Ile Ile Glu Asn Leu Gln Gln Asp Gly
        275                 280                 285
Ser Ser Phe Ala Leu Glu Gln Leu Lys Val Ile Asn Lys Met Ser Pro
    290                 295                 300
Thr Ser Leu Lys Ile Thr Leu Arg Gln Leu Met Glu Gly Ser Ser Lys
305                 310                 315                 320
Thr Leu Gln Glu Val Leu Thr Met Glu Tyr Arg Leu Ser Gln Ala Cys
                325                 330                 335
Met Arg Gly His Asp Phe His Glu Gly Val Arg Ala Val Leu Ile Asp
            340                 345                 350
Lys Asp Gln Ser Pro Lys Trp Lys Pro Ala Asp Leu Lys Glu Val Thr
        355                 360                 365
Glu Glu Asp Leu Asn Asn His Phe Lys Ser Leu Gly Ser Ser Asp Leu
    370                 375                 380
Lys Phe
385

<210> 2
<211> 2434
<212> DNA
<213> Homo sapiens

<400> 2
gggcggggct cacgcgaggc gctggaacgg tccgggagat tctcgctctg ctgctttagc      60
ttcggagtgt ttggcgatgg ggcagcgcga gatgtggagg ctcatgtcga ggtttaatgc     120
attcaaaagg actaatacca tactgcacca tttgagaatg tccaagcaca cagatgcagc     180
agaagaggtg ctattggaaa aaaaaggttg cacgggagtc ataacactaa acagaccaaa     240
gttcctcaat gcactgactc ttaatatgat tcggcagatt tatccacagc taaagaagtg     300
ggaacaagat cctgaaactt tcctgatcat tataaaggga gcaggaggaa aggctttctg     360
tgccgggggt gatatcagag tgatctcgga agctgaaaag gcaaaacaga agatagctcc     420
agttttcttc agagaagaat atatgctgaa taatgctgtt ggttcttgcc agaaacctta     480
tgttgcactt attcatggaa ttacaatggg tgggggagtt ggtctctcag tccatgggca     540
atttcgagtg gctacagaaa agtgtctttt tgctatgcca gaaactgcaa taggactgtt     600
ccctgatgtg ggtggaggtt atttcttgcc acgactccaa ggaaaacttg gttacttcct     660
tgcattaaca ggattcagac taaaaggaag agatgtgtac agagcaggaa ttgctacaca     720
ctttgtagat tctgaaaagt tggccatgtt agaggaagat ttgttagcct tgaaatctcc     780
ttcaaaagaa aatattgcat ctgtcttaga aaattaccat acagagtcta agattgatcg     840
agacaagtct tttatacttg aggaacacat ggacaaaata aacagttgtt tttcagccaa     900
tactgtggaa gaaattattg aaaacttaca gcaagatggt tcatcttttg ccctagagca     960
attgaaggta attaataaaa tgtctccaac atctctaaag atcacactaa ggcaactcat    1020
ggaggggtct tcaaagacct tgcaagaagt actaactatg gagtatcggc taagtcaagc    1080
ttgtatgaga ggtcatgact ttcatgaagg cgttagagct gttttaattg ataaagacca    1140
gagtccaaaa tggaaaccag ctgatctaaa agaagttact gaggaagatt tgaataatca    1200
ctttaagtct ttgggaagca gtgatttgaa attttgaggt gacaggcttt taaggtatat    1260
tttgtagcat gggttggcaa tctacagcat gtgggccaaa tccagcctgc tgcctgtttt    1320
tatataccct gtaagctaag aatggtttcc gcatttttaa atggttggga aaagaaatca    1380
aagactaata attcatgacg tgaaaattat cagaattcac aaataaagct ttattggaac    1440
tagctatact catctgttta tatattatct gtggctgctt tgaaatgagt agttgcaata    1500
gagatggtaa agcctacaaa gcctaattat ttactgtctg gtttttgtca gaaaaaagtt    1560
tgtcaatcct tgttttagaa gatggaaaaa tgtgaagatc tttggagatt ctcttgagtg    1620
gtatatctaa ttgaaatggg atcttcgttt ggcttgtatg ttgatgaaat caacttaggt    1680
atacaatata aaaaataaag accctgaaaa ttgttttgga tactgtgtta atgcctcata    1740
gaatttttgt tttggatact gtgttaatgc ctcatagaat tttctccata tatgagtgtg    1800
ttttaaagta actgagttac tgtagcagaa gagctccttt tataaacatt agaaaccttg    1860
ggcagagaga aaagattttt attaacgtcc ctcttcagta ttaactcaga cttggtcttc    1920
cctaaaataa tcagaatacc atcccatggt gaaactgaaa ggattatttt cttgttattt    1980
gtgatatttg ttaatctggt agaatgagaa attaggaaac tccaatctct tagatagaga    2040
cactctgttt ttttataatt tacgtaagac ttttgtgtga taattatcct tacaaacaag    2100
gttcaagtca ggagaaaaaa attaattgaa agcaagaaga cttttgttca aaagatatat    2160
tcaataattg atattgttaa tgaagtaagt actttttaag gtatgaaaga actaaaaggt    2220
attccagact cagaacctta aagttctagg caagaataat ttttaaacta aaggtaagtt    2280
tataaattaa caaagtaaac aaaatttatg attttgtttt ttgtttgtaa tttttgttta    2340
attttaaagg taagtttata aattaacaaa caaaatttat aattttttgt ttgtaatttt    2400
tgtttataaa caaaataaat tttttgtaac ttgt                                2434

<210> 3
<211> 140
<212> PRT
<213> Homo sapiens

<400> 3
Met Thr Ser Met Thr Gln Ser Leu Arg Glu Val Ile Lys Ala Met Thr
 1               5                  10                  15
Lys Ala Arg Asn Phe Glu Arg Val Leu Gly Lys Ile Thr Leu Val Ser
            20                  25                  30
Ala Ala Pro Gly Lys Val Ile Cys Glu Met Lys Val Glu Glu Glu His
        35                  40                  45
Thr Asn Ala Ile Gly Thr Leu His Gly Gly Leu Thr Ala Thr Leu Val
    50                  55                  60
Asp Asn Ile Ser Thr Met Ala Leu Leu Cys Thr Glu Arg Gly Ala Pro
65                  70                  75                  80
Gly Val Ser Val Asp Met Asn Ile Thr Tyr Met Ser Pro Ala Lys Leu
                85                  90                  95
Gly Glu Asp Ile Val Ile Thr Ala His Val Leu Lys Gln Gly Lys Thr
            100                 105                 110
Leu Ala Phe Thr Ser Val Asp Leu Thr Asn Lys Ala Thr Gly Lys Leu
        115                 120                 125
Ile Ala Gln Gly Arg His Thr Lys His Leu Gly Asn
    130                 135                 140

<210> 4
<211> 4041
<212> DNA
<213> Homo sapiens

<400> 4
agtgagcaaa tcgcggacca ccggggctgc cagctcgcct gactcccggc ctcttgcgct      60
cctaggggcg gagaagggtg cgggctcttc gccctttgtg tcctccttct ttcactaact     120
tctggacttt ccagctcttc cgaagttcgt tcttgcgcaa agcccaaagg ctggaaaacc     180
gtccacgatg accagcatga ctcagtctct gcgggaggtg ataaaggcca tgaccaaggc     240
tcgcaatttt gagagagttt tgggaaagat tactcttgtc tctgctgctc ctgggaaagt     300
gatttgtgaa atgaaagtag aagaagagca taccaatgca ataggcactc tccacggcgg     360
tttgacagcc acgttagtag ataacatatc aacaatggct ctgctatgca cggaaagggg     420
agcacccgga gtcagtgtcg atatgaacat aacgtacatg tcacctgcaa aattaggaga     480
agatatagtg attacagcac atgttctgaa gcaaggaaaa acacttgcat ttacctctgt     540
ggatctgacc aacaaggcca caggaaaatt aatagcacaa ggaagacaca caaaacacct     600
gggaaactga gagaacagca gaatgaccta aagaaaccca acaatgaata tcaagtatag     660
atttgactca aacaattgta atttttgaaa taaactagca aaaccagaag cagctagaaa     720
tattcttgga ggaaaaggac ctggatatca agtagggtaa aggtgggggt gtcttttttc     780
actttaagca tcttgttttc taatcatgtg tgataattgg gtgaaaaatt cttagctcaa     840
agtgttttaa aaacaggtaa agcaaagaaa ctagcaggac cactctcagt taagattaaa     900
actaaagtcc agtgttaagc taaaggagaa atagaaatta atggttctaa ttctgtttgg     960
gctgctagga acaacagaaa tttttcatgg ttctagaagc tggaaagtcc tgggtcaagg    1020
cccagcagat cctgttaggt gagggcccgc ttcctggctc atagatggtg ccttctcact    1080
gtgtggtgga aggggcaagt gagccctctg ggttctcgtt tttgaaatgg agtctcgctc    1140
tgttgcccag gctggagtac agcagcacga tctcggctca ctgcaatctc tgccccctgg    1200
gttcaagtga ttctcctgcc tcagcctccc aagtagctgg gactataggc atgtgccatc    1260
acacctagct aatttttgta gttttttgta gaaacagggt tcaccatgtt ggccaggctg    1320
gtctcgaact cgtgacctca ggtgatccgc ctgccttggc cccccaaagt gctgggatta    1380
caggtgtgag ccaatgtgcc cagcctgggt tctcttttgt aagggcactt actccaatct    1440
tgagggttct gccctcgtga tctaataact tcccaaagac ccccacctgc taatatcacc    1500
ttgggggttg ggattttaac atacaaattt aggggaaaca catggagacc acagcaatgg    1560
ccaatcctta gcgaatctta ggtccttccc agatctaaaa tgccaagcta cacttgcatt    1620
tccttttttt aagattatga aacttcaaaa tatatgaact acagcccata ttgaaaaata    1680
aaatagattg agccatatgc ctaaaaaaga cctcaagaaa agtttgaggc taagcatgtt    1740
agtgttacag gaaatggtcc aatagagggg gaagaaaaaa agcatgctac tagccccttt    1800
tcttgtaccg agaataaaac catgcagatc tcaaacctcc aagtctatag tattgaaaag    1860
accaagttca cttctcagaa gtctccaagt tcagttgact gtggcactct gagacagctt    1920
ctgtcactca ggctggagtg atacaatcac agcttcccat agcctcaaaa tcccaggctc    1980
aagacattct tccacctcag tctcctgagt agctggaact acaggcgtgt gccaccacgc    2040
ctaattttat ttttgtagaa acaaggtctc actgttgccc agcctcgtct caaactccta    2100
ggctcaagca atcctcctgc cttggccccc caagtactgg acttacaggt gtgaaccact    2160
gcacccagct gactcttact tgatttctgt cagggaatct taatgaacat ttcatgacta    2220
aagactaaaa aggatgcagc tttaagtaaa tttaagtcaa gttaacagtt aaagacaaat    2280
cctttcccta cattagatcg cctgctgatc tgtccactgt gaaagggcag aagactccac    2340
agtagcaata gcagcagtga gcatacagga gtcccagatg tttacttcta gtatttccca    2400
ctaaaaggaa gctgggctcc ttggagaaac agctgactcc agggcttgag gctgggacag    2460
aaaggttaca gtatcttatg catgaaagga gatgctcaaa ataataaagg catgcaaatt    2520
atgatttgga gggaaaaaat atgaggccat agtgtttagg tagataataa atggcagaga    2580
tagaacactc tcttacaaca aatgctgtaa atggacaaag cattagattt ggaaaatcac    2640
tattttgtaa ccatcatagt taaagactgg tttgggtttt agtctggaaa gaatcgccaa    2700
gggagctcct gataaaggaa cagggtattt gcacattgct tcccagagat tgctagtagt    2760
aagtaccaca catagggcaa aaccaggaca ccttgaccag gcgctcaaaa gtaacatcaa    2820
tgaagagcag atggagagta tacttgagaa gggcgttaag catgaataaa caattcaaat    2880
gcaaaatgag taacaattta caagaaaaat tgccctgtac tccaaaaaac atagaggtca    2940
tggaacacat aaaggctaag gaactgttcc acattaaaga caactgagaa caactaaatt    3000
caatgatcct gtactctaga gggggggatc taaaacaagc taccaaggat actgggacaa    3060
caaaacgaat atggatgata aagagtatca acattccctg agtttggtaa ttttactcta    3120
gttatatgaa atattcttgt acttggaaca tatgccgaag tactaaggaa ggggtaagga    3180
agcacaaagt gtgcaacaaa ctcaaatagc tcacaggtat aagtgtacag agaaaatgaa    3240
aaaaatgtgg caaaataata aaaatgaggg taaagattac acaacagctt tcatattact    3300
ctggtaactt ttctaaatta ttccaaaata aaaacgtaaa caatggctgc caaaatgcct    3360
aacttggtga acataagtgt aattcaatat ggtaaattaa ttcaacatgg taaattaaga    3420
gcataggcct taagagccag ccagcctggt tttaaatcct ccactactta tgatctgagc    3480
ttgagcaagt tacttaacct ctgcatctat ttccaccaaa ggttgagagg ttaagacaag    3540
agcttagaag agtacctggt tataataaac attcaaaatg ttatttcaaa tagattctaa    3600
tttttaaata agaggacaca tgaaagcatt ttgaaattta agaatggccc tttcccatga    3660
agcaaggcat aaggccaggt tgctaactgt tgaaagctga cagtatgttc ttgattcctg    3720
ttcttgttga agttacacac tcaattgcca ggtatttttc ttctgaattt actatttagc    3780
cacagactat gaaataattc tctaaggtga ccagtaacat cagtgaaatg gaaagaaaaa    3840
gttaacactt caaactttgt gtattcacct gaatagtcag ggaactttca cctattttat    3900
ttaggttttc tttttctttt tttctttttt tttcaaattc caaccagaag ctaaatacaa    3960
ttggaaactg gtaagcacta gttttactcc aaaggagtag gatcattcag atttactcca    4020
ataaaagtat gcaaccctta a                                              4041

<210> 5
<211> 474
<212> PRT
<213> Homo sapiens

<400> 5
Met Val Gln Gln Thr Asn Asn Ala Glu Asn Thr Glu Ala Leu Leu Ala
 1               5                  10                  15
Gly Glu Ser Ser Asp Ser Gly Ala Gly Leu Glu Leu Gly Ile Ala Ser
            20                  25                  30
Ser Pro Thr Pro Gly Ser Thr Ala Ser Thr Gly Gly Lys Ala Asp Asp
        35                  40                  45
Pro Ser Trp Cys Lys Thr Pro Ser Gly His Ile Lys Arg Pro Met Asn
    50                  55                  60
Ala Phe Met Val Trp Ser Gln Ile Glu Arg Arg Lys Ile Met Glu Gln
65                  70                  75                  80
Ser Pro Asp Met His Asn Ala Glu Ile Ser Lys Arg Leu Gly Lys Arg
                85                  90                  95
Trp Lys Leu Leu Lys Asp Ser Asp Lys Ile Pro Phe Ile Arg Glu Ala
            100                 105                 110
Glu Arg Leu Arg Leu Lys His Met Ala Asp Tyr Pro Asp Tyr Lys Tyr
        115                 120                 125
Arg Pro Arg Lys Lys Val Lys Ser Gly Asn Ala Asn Ser Ser Ser Ser
    130                 135                 140
Ala Ala Ala Ser Ser Lys Pro Gly Glu Lys Gly Asp Lys Val Gly Gly
145                 150                 155                 160
Ser Gly Gly Gly Gly His Gly Gly Gly Gly Gly Gly Gly Ser Ser Asn
                165                 170                 175
Ala Gly Gly Gly Gly Gly Gly Ala Ser Gly Gly Gly Ala Asn Ser Lys
            180                 185                 190
Pro Ala Gln Lys Lys Ser Cys Gly Ser Lys Val Ala Gly Gly Ala Gly
        195                 200                 205
Gly Gly Val Ser Lys Pro His Ala Lys Leu Ile Leu Ala Gly Gly Gly
    210                 215                 220
Gly Gly Gly Lys Ala Ala Ala Ala Ala Ala Ala Ser Phe Ala Ala Glu
225                 230                 235                 240
Gln Ala Gly Ala Ala Ala Leu Leu Pro Leu Gly Ala Ala Ala Asp His
                245                 250                 255
His Ser Leu Tyr Lys Ala Arg Thr Pro Ser Ala Ser Ala Ser Ala Ser
            260                 265                 270
Ser Ala Ala Ser Ala Ser Ala Ala Leu Ala Ala Pro Gly Lys His Leu
        275                 280                 285
Ala Glu Lys Lys Val Lys Arg Val Tyr Leu Phe Gly Gly Leu Gly Thr
    290                 295                 300
Ser Ser Ser Pro Val Gly Gly Val Gly Ala Gly Ala Asp Pro Ser Asp
305                 310                 315                 320
Pro Leu Gly Leu Tyr Glu Glu Glu Gly Ala Gly Cys Ser Pro Asp Ala
                325                 330                 335
Pro Ser Leu Ser Gly Arg Ser Ser Ala Ala Ser Ser Pro Ala Ala Gly
            340                 345                 350
Arg Ser Pro Ala Asp His Arg Gly Tyr Ala Ser Leu Arg Ala Ala Ser
        355                 360                 365
Pro Ala Pro Ser Ser Ala Pro Ser His Ala Ser Ser Ser Ala Ser Ser
    370                 375                 380
His Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Asp Asp Glu
385                 390                 395                 400
Phe Glu Asp Asp Leu Leu Asp Leu Asn Pro Ser Ser Asn Phe Glu Ser
                405                 410                 415
Met Ser Leu Gly Ser Phe Ser Ser Ser Ser Ala Leu Asp Arg Asp Leu
            420                 425                 430
Asp Phe Asn Phe Glu Pro Gly Ser Gly Ser His Phe Glu Phe Pro Asp
        435                 440                 445
Tyr Cys Thr Pro Glu Val Ser Glu Met Ile Ser Gly Asp Trp Leu Glu
    450                 455                 460
Ser Ser Ile Ser Asn Leu Val Phe Thr Tyr
465                 470

<210> 6
<211> 4869
<212> DNA
<213> Homo sapiens

<400> 6
gctctaagct gcagcaagag aaactgtgtg tgaggggaag aggcctgttt cgctgtcggg      60
tctctagttc ttgcacgctc tttaagagtc tgcactggag gaactcctgc cattaccagc     120
tcccttcttg cagaagggag ggggaaacat acatttattc atgccagtct gttgcatgca     180
ggctttttgg cttcctacct tgcaacaaaa taattgcacc aactccttag tgccgattcc     240
gcccacagag agtcctggag ccacagtctt ttttgctttg cattgtagga gagggactaa     300
gtgctagaga ctatgtcgct ttcctgagct accgagagcg ctcgtgaact ggaatcaact     360
gcttcaggga aaaagaaaaa aaaaaaaaaa agacttgcct gggaggccgc gagaaacttg     420
cattggaagc ttcagcaacc agcattcgag aaactcctct ctactttagc acggtctcca     480
gactcagccg agagacagca aactgcagcg cggtgagaga gcgagagaga gggagagaga     540
gactctccag cctgggaact ataactcctc tgcgagaggc ggagaactcc ttccccaaat     600
cttttgggga cttttctctc tttacccacc tccgcccctg cgaggagttg aggggccagt     660
tcggccgccg cgcgcgtctt cccgttcggc gtgtgcttgg cccggggaac cgggagggcc     720
cggcgatcgc gcggcggccg ccgcgagggt gtgagcgcgc gtgggcgccc gccgagccga     780
ggccatggtg cagcaaacca acaatgccga gaacacggaa gcgctgctgg ccggcgagag     840
ctcggactcg ggcgccggcc tcgagctggg aatcgcctcc tcccccacgc ccggctccac     900
cgcctccacg ggcggcaagg ccgacgaccc gagctggtgc aagaccccga gtgggcacat     960
caagcgaccc atgaacgcct tcatggtgtg gtcgcagatc gagcggcgca agatcatgga    1020
gcagtcgccc gacatgcaca acgccgagat ctccaagcgg ctgggcaaac gctggaagct    1080
gctcaaagac agcgacaaga tccctttcat tcgagaggcg gagcggctgc gcctcaagca    1140
catggctgac taccccgact acaagtaccg gcccaggaag aaggtgaagt ccggcaacgc    1200
caactccagc tcctcggccg ccgcctcctc caagccgggg gagaagggag acaaggtcgg    1260
tggcagtggc gggggcggcc atgggggcgg cggcggcggc gggagcagca acgcgggggg    1320
aggaggcggc ggtgcgagtg gcggcggcgc caactccaaa ccggcgcaga aaaagagctg    1380
cggctccaaa gtggcgggcg gcgcgggcgg tggggttagc aaaccgcacg ccaagctcat    1440
cctggcaggc ggcggcggcg gcgggaaagc agcggctgcc gccgccgcct ccttcgccgc    1500
cgaacaggcg ggggccgccg ccctgctgcc cctgggcgcc gccgccgacc accactcgct    1560
gtacaaggcg cggactccca gcgcctcggc ctccgcctcc tcggcagcct cggcctccgc    1620
agcgctcgcg gccccgggca agcacctggc ggagaagaag gtgaagcgcg tctacctgtt    1680
cggcggcctg ggcacgtcgt cgtcgcccgt gggcggcgtg ggcgcgggag ccgaccccag    1740
cgaccccctg ggcctgtacg aggaggaggg cgcgggctgc tcgcccgacg cgcccagcct    1800
gagcggccgc agcagcgccg cctcgtcccc cgccgccggc cgctcgcccg ccgaccaccg    1860
cggctacgcc agcctgcgcg ccgcctcgcc cgccccgtcc agcgcgccct cgcacgcgtc    1920
ctcctcggcc tcgtcccact cctcctcttc ctcctcctcg ggctcctcgt cctccgacga    1980
cgagttcgaa gacgacctgc tcgacctgaa ccccagctca aactttgaga gcatgtccct    2040
gggcagcttc agttcgtcgt cggcgctcga ccgggacctg gattttaact tcgagcccgg    2100
ctccggctcg cacttcgagt tcccggacta ctgcacgccc gaggtgagcg agatgatctc    2160
gggagactgg ctcgagtcca gcatctccaa cctggttttc acctactgaa gggcgcgcag    2220
gcagggagaa gggccggggg gggtaggaga ggagaaaaaa aaagtgaaaa aaagaaacga    2280
aaaggacaga cgaagagttt aaagagaaaa gggaaaaaag aaagaaaaag taagcagggc    2340
tggcttcgcc cgcgttctcg tcgtcggatc aaggagcgcg gcggcgtttt ggacccgcgc    2400
tcccatcccc caccttcccg ggccggggac ccactctgcc cagccggagg gacgcggagg    2460
aggaagaggg tagacagggg cgacctgtga ttgttgttat tgatgttgtt gttgatggca    2520
aaaaaaaaaa agcgacttcg agtttgctcc cctttgcttg aagagacccc ctcccccttc    2580
caacgagctt ccggacttgt ctgcaccccc agcaagaagg cgagttagtt ttctagagac    2640
ttgaaggagt ctcccccttc ctgcatcacc accttggttt tgttttattt tgcttcttgg    2700
tcaagaaagg aggggagaac ccagcgcacc cctccccccc tttttttaaa cgcgtgatga    2760
agacagaagg ctccggggtg acgaatttgg ccgatggcag atgttttggg ggaacgccgg    2820
gactgagaga ctccacgcag gcgaattccc gtttggggct tttttttcct ccctcttttc    2880
cccttgcccc ctctgcagcc ggaggaggag atgttgaggg gaggaggcca gccagtgtga    2940
ccggcgctag gaaatgaccc gagaaccccg ttggaagcgc agcagcggga gctaggggcg    3000
ggggcggagg aggacacgaa ctggaagggg gttcacggtc aaactgaaat ggatttgcac    3060
gttggggagc tggcggcggc ggctgctggg cctccgcctt cttttctacg tgaaatcagt    3120
gaggtgagac ttcccagacc ccggaggcgt ggaggagagg agactgtttg atgtggtaca    3180
ggggcagtca gtggagggcg agtggtttcg gaaaaaaaaa aagaaaaaaa gaaaaaaaaa    3240
gaaaaaaaaa agattttttt cttctcttaa tcggaatcgt gatggtgttg gattatttca    3300
atggtggggt taatatagca tgttatcctg tctatctttt aaagatttct gtataagact    3360
gttgagcagt ttttaaaata gtgtaggata atataaaaag cagatagatg gcgctatgtt    3420
tgattcctac aacgaaatta tcaccagctt tttttcattc ttaactcttt aaaggattca    3480
aacgcaactc aaatctgtgc tggactttaa aaaaacaatt caggaccaaa ttttttctca    3540
gtgtgtgtgt ttattcctta taggtgtaaa tgagaagacg tgtttttttc cttcaccgat    3600
gctccatcct cgtatttctt tttccttgta aatgtaatca gatgccattt tatatgtgga    3660
cgtatttata ctggccaaac atattttttc ttttgtccct ttttttcttt cctttctttt    3720
tacttccttt atttctttat tccttccttt tccttttttt cttttttttt tctttttttt    3780
tttttttttt tggtagttgt tgttacccac gccattttac gtctccttca ctgaagggct    3840
agagttttaa cttttaattt tttatattta aatgtagact tttgacactt ttaaaaaaca    3900
aaaaaagaca agagagatga aaacgtttga ttattttctc agtgtatttt tgtaaaaaat    3960
atataaaggg ggtgttaatc ggtgtaaatc gctgtttgga tttcctgatt ttataacagg    4020
gcggctggtt aatatctcac acagtttaaa aaatcagccc ctaatttctc catgtttaca    4080
cttcaatctg caggcttctt aaagtgacag tatcccttaa cctgccacca gtgtccaccc    4140
tccggccccc gtcttgtaaa aaggggagga gaattagcca aacactgtaa gcttttaaga    4200
aaaacaaagt tttaaacgaa atactgctct gtccagaggc tttaaaactg gtgcaattac    4260
agcaaaaagg gattctgtag ctttaacttg taaaccacat cttttttgca ctttttttat    4320
aagcaaaaac gtgccgttta aaccactgga tctatctaaa tgccgatttg agttcgcgac    4380
actatgtact gcgtttttca ttcttgtatt tgactattta atcctttcta cttgtcgcta    4440
aatataattg ttttagtctt atggcatgat gatagcatat gtgttcaggt ttatagctgt    4500
tgtgtttaaa aattgaaaaa agtggaaaac atctttgtac atttaagtct gtattataat    4560
aagcaaaaag attgtgtgta tgtatgttta atataacatg acaggcacta ggacgtctgc    4620
ctttttaagg cagttccgtt aagggttttt gtttttaaac ttttttttgc catccatcct    4680
gtgcaatatg ccgtgtagaa tatttgtctt aaaattcaag gccacaaaaa caatgtttgg    4740
gggaaaaaaa agaaaaaatc atgccagcta atcatgtcaa gttcactgcc tgtcagattg    4800
ttgatatata ccttctgtaa ataacttttt ttgagaagga aataaaatca gctggaactg    4860
aaccctaaa                                                            4869

<210> 7
<211> 413
<212> PRT
<213> Homo sapiens

<400> 7
Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr
 1               5                  10                  15
Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe
            20                  25                  30
Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu
        35                  40                  45
Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro
    50                  55                  60
Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu
65                  70                  75                  80
Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu
                85                  90                  95
Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe
            100                 105                 110
Pro Ser Glu Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile
        115                 120                 125
Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val
    130                 135                 140
Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val
145                 150                 155                 160
Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu
                165                 170                 175
Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg
            180                 185                 190
Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu
        195                 200                 205
Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His
    210                 215                 220
Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn
225                 230                 235                 240
Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser
                245                 250                 255
Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys
            260                 265                 270
Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr
        275                 280                 285
Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp
    290                 295                 300
Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro
305                 310                 315                 320
Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu
                325                 330                 335
Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu
            340                 345                 350
Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr
        355                 360                 365
Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu
    370                 375                 380
Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu
385                 390                 395                 400
Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser
                405                 410

<210> 8
<211> 2570
<212> DNA
<213> Homo sapiens

<400> 8
gcccctcccg tcagttcgcc agctgccagc cccgggacct tttcatctct tcccttttgg      60
ccggaggagc cgagttcaga tccgccactc cgcacccgag actgacacac tgaactccac     120
ttcctcctct taaatttatt tctacttaat agccactcgt ctcttttttt ccccatctca     180
ttgctccaag aatttttttc ttcttactcg ccaaagtcag ggttccctct gcccgtcccg     240
tattaatatt tccacttttg gaactactgg ccttttcttt ttaaaggaat tcaagcagga     300
tacgtttttc tgttgggcat tgactagatt gtttgcaaaa gtttcgcatc aaaaacaaca     360
acaacaaaaa accaaacaac tctccttgat ctatactttg agaattgttg atttcttttt     420
tttattctga cttttaaaaa caactttttt ttccactttt ttaaaaaatg cactactgtg     480
tgctgagcgc ttttctgatc ctgcatctgg tcacggtcgc gctcagcctg tctacctgca     540
gcacactcga tatggaccag ttcatgcgca agaggatcga ggcgatccgc gggcagatcc     600
tgagcaagct gaagctcacc agtcccccag aagactatcc tgagcccgag gaagtccccc     660
cggaggtgat ttccatctac aacagcacca gggacttgct ccaggagaag gcgagccgga     720
gggcggccgc ctgcgagcgc gagaggagcg acgaagagta ctacgccaag gaggtttaca     780
aaatagacat gccgcccttc ttcccctccg aaactgtctg cccagttgtt acaacaccct     840
ctggctcagt gggcagcttg tgctccagac agtcccaggt gctctgtggg taccttgatg     900
ccatcccgcc cactttctac agaccctact tcagaattgt tcgatttgac gtctcagcaa     960
tggagaagaa tgcttccaat ttggtgaaag cagagttcag agtctttcgt ttgcagaacc    1020
caaaagccag agtgcctgaa caacggattg agctatatca gattctcaag tccaaagatt    1080
taacatctcc aacccagcgc tacatcgaca gcaaagttgt gaaaacaaga gcagaaggcg    1140
aatggctctc cttcgatgta actgatgctg ttcatgaatg gcttcaccat aaagacagga    1200
acctgggatt taaaataagc ttacactgtc cctgctgcac ttttgtacca tctaataatt    1260
acatcatccc aaataaaagt gaagaactag aagcaagatt tgcaggtatt gatggcacct    1320
ccacatatac cagtggtgat cagaaaacta taaagtccac taggaaaaaa aacagtggga    1380
agaccccaca tctcctgcta atgttattgc cctcctacag acttgagtca caacagacca    1440
accggcggaa gaagcgtgct ttggatgcgg cctattgctt tagaaatgtg caggataatt    1500
gctgcctacg tccactttac attgatttca agagggatct agggtggaaa tggatacacg    1560
aacccaaagg gtacaatgcc aacttctgtg ctggagcatg cccgtattta tggagttcag    1620
acactcagca cagcagggtc ctgagcttat ataataccat aaatccagaa gcatctgctt    1680
ctccttgctg cgtgtcccaa gatttagaac ctctaaccat tctctactac attggcaaaa    1740
cacccaagat tgaacagctt tctaatatga ttgtaaagtc ttgcaaatgc agctaaaatt    1800
cttggaaaag tggcaagacc aaaatgacaa tgatgatgat aatgatgatg acgacgacaa    1860
cgatgatgct tgtaacaaga aaacataaga gagccttggt tcatcagtgt taaaaaattt    1920
ttgaaaaggc ggtactagtt cagacacttt ggaagtttgt gttctgtttg ttaaaactgg    1980
catctgacac aaaaaaagtt gaaggcctta ttctacattt cacctacttt gtaagtgaga    2040
gagacaagaa gcaaattttt tttaaagaaa aaaataaaca ctggaagaat ttattagtgt    2100
taattatgtg aacaacgaca acaacaacaa caacaacaaa caggaaaatc ccattaagtg    2160
gagttgctgt acgtaccgtt cctatcccgc gcctcacttg atttttctgt attgctatgc    2220
aataggcacc cttcccattc ttactcttag agttaacagt gagttattta ttgtgtgtta    2280
ctatataatg aacgtttcat tgcccttgga aaataaaaca ggtgtataaa gtggagacca    2340
aatactttgc cagaaactca tggatggctt aaggaacttg aactcaaacg agccagaaaa    2400
aaagaggtca tattaatggg atgaaaaccc aagtgagtta ttatatgacc gagaaagtct    2460
gcattaagat aaagaccctg aaaacacatg ttatgtatca gctgcctaag gaagcttctt    2520
gtaaggtcca aaaactaaaa agactgttaa taaaagaaac tttcagtcag               2570

<210> 9
<211> 9
<212> RNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 9
uucaagaga                                                               9

<210> 10
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 10
gagccaagag tgaagaacag tc                                               22

<210> 11
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 11
gctccccacc atattctgaa tct                                              23

<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 12
catgtacgtt gctatccagg c                                                21

<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 13
ctccttaatg tcacgcacga t                                                21

<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 14
catctctacc atctccttca gc                                               22

<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 15
cagagtcatc cagttgtacc g                                                21

<210> 16
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 16
cccaccacgt acaagggtc                                                   19

<210> 17
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 17
ctggggtatt gggggcatc                                                   19

<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 18
cccaagacaa agagacccag                                                  20

<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 19
gccactgtgc ttactgaatt g                                                21

<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 20
cagtgggaga cctcgagaag                                                  20

<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 21
tccctcggaa catcagaaac                                                  20

<210> 22
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 22
acatgattca gccacagata cc                                               22

<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 23
gcatagatgt cagcacgttt g                                                21

<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 24
aaggagtttg tggatgccc                                                   19

<210> 25
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 25
gctacgtctg ccatcttata cac                                              23

<210> 26
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 26
ctctgtgagc tagatcggtt g                                                21

<210> 27
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 27
ggaggctggg tcttttctta tc                                               22

<210> 28
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 28
gaggtttaca aaatagacat gccg                                             24

<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 29
actctgaact ctgctttcac c                                                21

<210> 30
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 30
atgccgcctt taactggag                                                   19

<210> 31
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 31
ggaagccagg atccatttt                                                   19

<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 32
ccttggctcc ttgaactttt g                                                21

<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 33
ctgtccacgt cctgattctg                                                  20

<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 34
acaagcttct aggacaagag c                                                21

<210> 35
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 35
gcactccttg gcaaaactg                                                   19

<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 36
cagaagtggg ttcaggattc c                                                21

<210> 37
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 37
attcttgggt tgtggagtga g                                                21

<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 38
ctttcaacgc ttccctgatg                                                  20

<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 39
ccgtgccatt gtttgcttta                                                  20

<210> 40
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 40
ggacgccagg aatgttctt                                                   19

<210> 41
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 41
tgtggttgtc cttggctc                                                    18

<210> 42
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 42
ggctgttcgc tgaaggag                                                    18

<210> 43
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 43
cgtctggtat ttggtgtagg g                                                21

<210> 44
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 44
aggtctccgt gtccagtc                                                    18

<210> 45
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 45
gcgtttggtg cttagtgtaa g                                                21

<210> 46
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 46
ggacacgcct tctgaacg                                                    18

<210> 47
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 47
cggagtccag tgtggtttg                                                   19

<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 48
tggctgtggg aaagtctatg                                                  20

<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 49
gtctgagcgg gagaactttt                                                  20

<210> 50
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 50
agcgacaaga tccctttcat tc                                               22

<210> 51
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 51
cgttgccgga cttcacctt                                                   19

<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 52
ttcggacagt acaaagaacg g                                                21

<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 53
gcatttcata agtctcacgg c                                                21

<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 54
ggctacaaga tgaccactga g                                                21

<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 55
ctctgacctc cgtttctgtt c                                                21

<210> 56
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 56
gtgctggaac ttcaatgtct tg                                               22

<210> 57
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 57
ctctcctgag gctcttcct                                                   19

<210> 58
<211> 728
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Gly Phe Trp Val Gly Thr Ala Pro Leu Val Ala Ala Gly Arg
 1               5                  10                  15
Arg Gly Arg Trp Pro Pro Gln Gln Leu Met Leu Ser Ala Ala Leu Arg
            20                  25                  30
Thr Leu Lys His Val Leu Tyr Tyr Ser Arg Gln Cys Leu Met Val Ser
        35                  40                  45
Arg Asn Leu Gly Ser Val Gly Tyr Asp Pro Asn Glu Lys Thr Phe Asp
    50                  55                  60
Lys Ile Leu Val Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Ile Arg
65                  70                  75                  80
Thr Cys Lys Lys Met Gly Ile Lys Thr Val Ala Ile His Ser Asp Val
                85                  90                  95
Asp Ala Ser Ser Val His Val Lys Met Ala Asp Glu Ala Val Cys Val
            100                 105                 110
Gly Pro Ala Pro Thr Ser Lys Ser Tyr Leu Asn Met Asp Ala Ile Met
        115                 120                 125
Glu Ala Ile Lys Lys Thr Arg Ala Gln Ala Val His Pro Gly Tyr Gly
    130                 135                 140
Phe Leu Ser Glu Asn Lys Glu Phe Ala Arg Cys Leu Ala Ala Glu Asp
145                 150                 155                 160
Val Val Phe Ile Gly Pro Asp Thr His Ala Ile Gln Ala Met Gly Asp
                165                 170                 175
Lys Ile Glu Ser Lys Leu Leu Ala Lys Lys Ala Glu Val Asn Thr Ile
            180                 185                 190
Pro Gly Phe Asp Gly Val Val Lys Asp Ala Glu Glu Ala Val Arg Ile
        195                 200                 205
Ala Arg Glu Ile Gly Tyr Pro Val Met Ile Lys Ala Ser Ala Gly Gly
    210                 215                 220
Gly Gly Lys Gly Met Arg Ile Ala Trp Asp Asp Glu Glu Thr Arg Asp
225                 230                 235                 240
Gly Phe Arg Leu Ser Ser Gln Glu Ala Ala Ser Ser Phe Gly Asp Asp
                245                 250                 255
Arg Leu Leu Ile Glu Lys Phe Ile Asp Asn Pro Arg His Ile Glu Ile
            260                 265                 270
Gln Val Leu Gly Asp Lys His Gly Asn Ala Leu Trp Leu Asn Glu Arg
        275                 280                 285
Glu Cys Ser Ile Gln Arg Arg Asn Gln Lys Val Val Glu Glu Ala Pro
    290                 295                 300
Ser Ile Phe Leu Asp Ala Glu Thr Arg Arg Ala Met Gly Glu Gln Ala
305                 310                 315                 320
Val Ala Leu Ala Arg Ala Val Lys Tyr Ser Ser Ala Gly Thr Val Glu
                325                 330                 335
Phe Leu Val Asp Ser Lys Lys Asn Phe Tyr Phe Leu Glu Met Asn Thr
            340                 345                 350
Arg Leu Gln Val Glu His Pro Val Thr Glu Cys Ile Thr Gly Leu Asp
        355                 360                 365
Leu Val Gln Glu Met Ile Arg Val Ala Lys Gly Tyr Pro Leu Arg His
    370                 375                 380
Lys Gln Ala Asp Ile Arg Ile Asn Gly Trp Ala Val Glu Cys Arg Val
385                 390                 395                 400
Tyr Ala Glu Asp Pro Tyr Lys Ser Phe Gly Leu Pro Ser Ile Gly Arg
                405                 410                 415
Leu Ser Gln Tyr Gln Glu Pro Leu His Leu Pro Gly Val Arg Val Asp
            420                 425                 430
Ser Gly Ile Gln Pro Gly Ser Asp Ile Ser Ile Tyr Tyr Asp Pro Met
        435                 440                 445
Ile Ser Lys Leu Ile Thr Tyr Gly Ser Asp Arg Thr Glu Ala Leu Lys
    450                 455                 460
Arg Met Ala Asp Ala Leu Asp Asn Tyr Val Ile Arg Gly Val Thr His
465                 470                 475                 480
Asn Ile Ala Leu Leu Arg Glu Val Ile Ile Asn Ser Arg Phe Val Lys
                485                 490                 495
Gly Asp Ile Ser Thr Lys Phe Leu Ser Asp Val Tyr Pro Asp Gly Phe
            500                 505                 510
Lys Gly His Met Leu Thr Lys Ser Glu Lys Asn Gln Leu Leu Ala Ile
        515                 520                 525
Ala Ser Ser Leu Phe Val Ala Phe Gln Leu Arg Ala Gln His Phe Gln
    530                 535                 540
Glu Asn Ser Arg Met Pro Val Ile Lys Pro Asp Ile Ala Asn Trp Glu
545                 550                 555                 560
Leu Ser Val Lys Leu His Asp Lys Val His Thr Val Val Ala Ser Asn
                565                 570                 575
Asn Gly Ser Val Phe Ser Val Glu Val Asp Gly Ser Lys Leu Asn Val
            580                 585                 590
Thr Ser Thr Trp Asn Leu Ala Ser Pro Leu Leu Ser Val Ser Val Asp
        595                 600                 605
Gly Thr Gln Arg Thr Val Gln Cys Leu Ser Arg Glu Ala Gly Gly Asn
    610                 615                 620
Met Ser Ile Gln Phe Leu Gly Thr Val Tyr Lys Val Asn Ile Leu Thr
625                 630                 635                 640
Arg Leu Ala Ala Glu Leu Asn Lys Phe Met Leu Glu Lys Val Thr Glu
                645                 650                 655
Asp Thr Ser Ser Val Leu Arg Ser Pro Met Pro Gly Val Val Val Ala
            660                 665                 670
Val Ser Val Lys Pro Gly Asp Ala Val Ala Glu Gly Gln Glu Ile Cys
        675                 680                 685
Val Ile Glu Ala Met Lys Met Gln Asn Ser Met Thr Ala Gly Lys Thr
    690                 695                 700
Gly Thr Val Lys Ser Val His Cys Gln Ala Gly Asp Thr Val Gly Glu
705                 710                 715                 720
Gly Asp Leu Leu Val Glu Leu Glu
                725

<210> 59
<211> 2484
<212> DNA
<213> Homo sapiens

<400> 59
agcagagggg cggtctgcgg ggacaacaat ggcggggttc tgggtcggga cagcaccgct      60
ggtcgctgcc ggacggcgtg ggcggtggcc gccgcagcag ctgatgctga gcgcggcgct     120
gcggaccctg aagcatgttc tgtactattc aagacagtgc ttaatggtgt cccgtaatct     180
tggttcagtg ggatatgatc ctaatgaaaa aacttttgat aaaattcttg ttgctaatag     240
aggagaaatt gcatgtcggg ttattagaac ttgcaagaag atgggcatta agacagttgc     300
catccacagt gatgttgatg ctagttctgt tcatgtgaaa atggcggatg aggctgtctg     360
tgttggccca gctcccacca gtaaaagcta cctcaacatg gatgccatca tggaagccat     420
taagaaaacc agggcccaag ctgtacatcc aggttatgga ttcctttcag aaaacaaaga     480
atttgccaga tgtttggcag cagaagatgt cgttttcatt ggacctgaca cacatgctat     540
tcaagccatg ggcgacaaga ttgaaagcaa attattagct aagaaagcag aggttaatac     600
aatccctggc tttgatggag tagtcaagga tgcagaagaa gctgtcagaa ttgcaaggga     660
aattggctac cctgtcatga tcaaggcctc agcaggtggt ggtgggaaag gcatgcgcat     720
tgcttgggat gatgaagaga ccagggatgg ttttagattg tcatctcaag aagctgcttc     780
tagttttggc gatgatagac tactaataga aaaatttatt gataatcctc gtcatataga     840
aatccaggtt ctaggtgata aacatgggaa tgctttatgg cttaatgaaa gagagtgctc     900
aattcagaga agaaatcaga aggtggtgga ggaagcacca agcatttttt tggatgcgga     960
gactcgaaga gcgatgggag aacaagctgt agctcttgcc agagcagtaa aatattcctc    1020
tgctgggacc gtggagttcc ttgtggactc taagaagaat ttttatttct tggaaatgaa    1080
tacaagactc caggttgagc atcctgtcac agaatgcatt actggcctgg acctagtcca    1140
ggaaatgatc cgtgttgcta agggctaccc tctcaggcac aaacaagctg atattcgcat    1200
caacggctgg gcagttgaat gtcgggttta tgctgaggac ccctacaagt cttttggttt    1260
accatctatt gggagattgt ctcagtacca agaaccgtta catctacctg gtgtccgagt    1320
ggacagtggc atccaaccag gaagtgatat tagcatttat tatgatccta tgatttcaaa    1380
actaatcaca tatggctctg atagaactga ggcactgaag agaatggcag atgcactgga    1440
taactatgtt attcgaggtg ttacacataa tattgcatta cttcgagagg tgataatcaa    1500
ctcacgcttt gtaaaaggag acatcagcac taaatttctc tccgatgtgt atcctgatgg    1560
cttcaaagga cacatgctaa ccaagagtga gaagaaccag ttattggcaa tagcatcatc    1620
attgtttgtg gcattccagt taagagcaca acattttcaa gaaaattcaa gaatgcctgt    1680
tattaaacca gacatagcca actgggagct ctcagtaaaa ttgcatgata aagttcatac    1740
cgtagtagca tcaaacaatg ggtcagtgtt ctcggtggaa gttgatgggt cgaaactaaa    1800
tgtgaccagc acgtggaacc tggcttcgcc cttattgtct gtcagcgttg atggcactca    1860
gaggactgtc cagtgtcttt ctcgagaagc aggtggaaac atgagcattc agtttcttgg    1920
tacagtgtac aaggtgaata tcttaaccag acttgccgca gaattgaaca aatttatgct    1980
ggaaaaagtg actgaggaca caagcagtgt tctgcgttcc ccgatgcccg gagtggtggt    2040
ggccgtctct gtcaagcctg gagacgcggt agcagaaggt caagaaattt gtgtgattga    2100
agccatgaaa atgcagaata gtatgacagc tgggaaaact ggcacggtga aatctgtgca    2160
ctgtcaagct ggagacacag ttggagaagg ggatctgctc gtggagctgg aatgaaggat    2220
ttataacctt tcagtcatca cccaatttaa ttagccattt gcatgatgct ttcacacaca    2280
attgattcaa gcattataca ggaacacccc tgtgcagcta cgtttacgtc gtcatttatt    2340
ccacagagtc aagaccaata ttctgccaaa aaatcaccaa tggaaatttt cattgatata    2400
aatacttgta catatgattt gtacttctgc tgtgagattc cctagtgtca aaattaaatc    2460
aataaaactg agcatttgtc taaa                                           2484
