                         SEQUENCE LISTING

<110>  EXELIXIS, INC.
 
<120>  MULTISPECIFIC BINDING AGENTS AND USES THEREOF

<130>  14529-008-228

<140>
<141>

<150>  US 63/061,112
<151>  2020-08-04

<160>  217   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR1 (Exemplary, AbM)

<400>  1

Gly Phe Thr Phe Ser Tyr Tyr Tyr Ile His 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR2 (Exemplary, Kabat)

<400>  2

Trp Ile Asp Pro Tyr Gly His Ser Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR3 (Exemplary, Kabat, AbM)

<400>  3

Gly Gly Arg Gly Ala Met Asp Tyr 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR1 (Exemplary, Kabat, AbM)

<400>  4

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR2 (Exemplary, Kabat, AbM)

<400>  5

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  6

Gln Gln Arg Tyr Ser Ser Leu Leu Thr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR1 (IMGT)

<400>  7

Gly Phe Thr Phe Ser Tyr Tyr Tyr 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR2 (IMGT)

<400>  8

Ile Asp Pro Tyr Gly His Ser Thr 
1               5               


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR3 (IMGT)

<400>  9

Ala Arg Gly Gly Arg Gly Ala Met Asp Tyr 
1               5                   10  


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR1 (IMGT)

<400>  10

Gln Ser Val Ser Ser Ala 
1               5       


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR2 (IMGT, Chothia)

<400>  11

Ser Ala Ser 
1           


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR1 (Kabat)

<400>  12

Tyr Tyr Tyr Ile His 
1               5   


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR1 (Chothia)

<400>  13

Gly Phe Thr Phe Ser Tyr Tyr 
1               5           


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR2 (Chothia)

<400>  14

Pro Tyr Gly His 
1               


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR3 (Chothia)

<400>  15

Gly Arg Gly Ala Met Asp 
1               5       


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR1 (Chothia)

<400>  16

Ser Gln Ser Val Ser Ser Ala 
1               5           


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR3 (Chothia)

<400>  17

Arg Tyr Ser Ser Leu Leu 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR1 (Contact)

<400>  18

Ser Tyr Tyr Tyr Ile His 
1               5       


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR2 (Contact)

<400>  19

Trp Val Ala Trp Ile Asp Pro Tyr Gly His Ser Thr Thr 
1               5                   10              


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR3 (Contact)

<400>  20

Ala Arg Gly Gly Arg Gly Ala Met Asp 
1               5                   


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR1 (Contact)

<400>  21

Ser Ser Ala Val Ala Trp Tyr 
1               5           


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR2 (Contact)

<400>  22

Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr 
1               5                   10  


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL CDR3 (Contact)

<400>  23

Gln Gln Arg Tyr Ser Ser Leu Leu 
1               5               


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH CDR2 (AbM)

<400>  24

Trp Ile Asp Pro Tyr Gly His Ser Thr Thr 
1               5                   10  


<210>  25
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VH Sequence

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Asp Pro Tyr Gly His Ser Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr 
        


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C40 VL Sequence

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Tyr Ser Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR1 (Exemplary, AbM)

<400>  27

Gly Phe Thr Phe Thr Tyr Tyr Tyr Ile His 
1               5                   10  


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR2 (Exemplary, Kabat)

<400>  28

Phe Ile Asp Pro Tyr Ser Gly Ser Thr Glu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR3 (Exemplary, Kabat, AbM)

<400>  29

Gly Gly Leu Tyr Ala Leu Asp Tyr 
1               5               


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR1 (Exemplary, Kabat, AbM)

<400>  30

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR2 (Exemplary, Kabat, AbM)

<400>  31

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  32

Gln Gln Gly Arg Ser Asp Leu Arg Thr 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR1 (IMGT)

<400>  33

Gly Phe Thr Phe Thr Tyr Tyr Tyr 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR2 (IMGT)

<400>  34

Ile Asp Pro Tyr Ser Gly Ser Thr 
1               5               


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR3 (IMGT)

<400>  35

Ala Arg Gly Gly Leu Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR1 (IMGT)

<400>  36

Gln Ser Val Ser Ser Ala 
1               5       


<210>  37
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR2 (IMGT, Chothia)

<400>  37

Ser Ala Ser 
1           


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR1 (Kabat)

<400>  38

Tyr Tyr Tyr Ile His 
1               5   


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR1 (Chothia)

<400>  39

Gly Phe Thr Phe Thr Tyr Tyr 
1               5           


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR2 (Chothia)

<400>  40

Pro Tyr Ser Gly 
1               


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR3 (Chothia)

<400>  41

Gly Leu Tyr Ala Leu Asp 
1               5       


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR1 (Chothia)

<400>  42

Ser Gln Ser Val Ser Ser Ala 
1               5           


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR3 (Chothia)

<400>  43

Gly Arg Ser Asp Leu Arg 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR1 (Contact)

<400>  44

Thr Tyr Tyr Tyr Ile His 
1               5       


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR2 (Contact)

<400>  45

Trp Val Ala Phe Ile Asp Pro Tyr Ser Gly Ser Thr Glu 
1               5                   10              


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR3 (Contact)

<400>  46

Ala Arg Gly Gly Leu Tyr Ala Leu Asp 
1               5                   


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR1 (Contact)

<400>  47

Ser Ser Ala Val Ala Trp Tyr 
1               5           


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR2 (Contact)

<400>  48

Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr 
1               5                   10  


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL CDR3 (Contact)

<400>  49

Gln Gln Gly Arg Ser Asp Leu Arg 
1               5               


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH CDR2 (AbM)

<400>  50

Phe Ile Asp Pro Tyr Ser Gly Ser Thr Glu 
1               5                   10  


<210>  51
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VH Sequence

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Tyr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Asp Pro Tyr Ser Gly Ser Thr Glu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr 
        


<210>  52
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C56 VL Sequence

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Ser Asp Leu Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR1 (Exemplary, AbM)

<400>  53

Gly Phe Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   10  


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR2 (Exemplary, Kabat)

<400>  54

Tyr Ile Asp Ser Lys His Gly Thr Thr Gln Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR3 (Exemplary, Kabat, AbM)

<400>  55

Gly Gly Arg Ser Ala Met Asp Tyr 
1               5               


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR1 (Exemplary, Kabat, AbM)

<400>  56

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR2 (Exemplary, Kabat, AbM)

<400>  57

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  58

Gln Gln Arg Thr Thr Ser Leu Leu Thr 
1               5                   


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR1 (IMGT)

<400>  59

Gly Phe Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR2 (IMGT)

<400>  60

Ile Asp Ser Lys His Gly Thr Thr 
1               5               


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR3 (IMGT)

<400>  61

Ala Arg Gly Gly Arg Ser Ala Met Asp Tyr 
1               5                   10  


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR1 (IMGT)

<400>  62

Gln Ser Val Ser Ser Ala 
1               5       


<210>  63
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR2 (IMGT, Chothia)

<400>  63

Ser Ala Ser 
1           


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR1 (Kabat)

<400>  64

Ser Tyr Tyr Ile His 
1               5   


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR1 (Chothia)

<400>  65

Gly Phe Thr Phe Thr Ser Tyr 
1               5           


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR2 (Chothia)

<400>  66

Ser Lys His Gly 
1               


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR3 (Chothia)

<400>  67

Gly Arg Ser Ala Met Asp 
1               5       


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR1 (Chothia)

<400>  68

Ser Gln Ser Val Ser Ser Ala 
1               5           


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR3 (Chothia)

<400>  69

Arg Thr Thr Ser Leu Leu 
1               5       


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR1 (Contact)

<400>  70

Thr Ser Tyr Tyr Ile His 
1               5       


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR2 (Contact)

<400>  71

Trp Val Ala Tyr Ile Asp Ser Lys His Gly Thr Thr Gln 
1               5                   10              


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR3 (Contact)

<400>  72

Ala Arg Gly Gly Arg Ser Ala Met Asp 
1               5                   


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR1 (Contact)

<400>  73

Ser Ser Ala Val Ala Trp Tyr 
1               5           


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR2 (Contact)

<400>  74

Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr 
1               5                   10  


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL CDR3 (Contact)

<400>  75

Gln Gln Arg Thr Thr Ser Leu Leu 
1               5               


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH CDR2 (AbM)

<400>  76

Tyr Ile Asp Ser Lys His Gly Thr Thr Gln 
1               5                   10  


<210>  77
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VH Sequence

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Lys His Gly Thr Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr 
        


<210>  78
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody C59 VL Sequence

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Thr Thr Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR1 (Exemplary, AbM)

<400>  79

Gly Phe Thr Phe Ser Ser Tyr Tyr Ile His 
1               5                   10  


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR2 (Exemplary, Kabat)

<400>  80

Trp Ile Thr Ser His Gly Tyr Ser Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR3 (Exemplary, Kabat, AbM)

<400>  81

Asp Ser Val Ile Tyr Gly Leu Asp Tyr 
1               5                   


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR1 (Exemplary, Kabat, AbM)

<400>  82

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR2 (Exemplary, Kabat, AbM)

<400>  83

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  84

Gln Gln Tyr Tyr Thr Ser Pro Tyr Thr 
1               5                   


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR1 (IMGT)

<400>  85

Gly Phe Thr Phe Ser Ser Tyr Tyr 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR2 (IMGT)

<400>  86

Ile Thr Ser His Gly Tyr Ser Thr 
1               5               


<210>  87
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR3 (IMGT)

<400>  87

Ala Arg Asp Ser Val Ile Tyr Gly Leu Asp Tyr 
1               5                   10      


<210>  88
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR1 (IMGT)

<400>  88

Gln Ser Val Ser Ser Ala 
1               5       


<210>  89
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR2 (IMGT, Chothia)

<400>  89

Ser Ala Ser 
1           


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR1 (Kabat)

<400>  90

Ser Tyr Tyr Ile His 
1               5   


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR1 (Chothia)

<400>  91

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR2 (Chothia)

<400>  92

Ser His Gly Tyr 
1               


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR3 (Chothia)

<400>  93

Ser Val Ile Tyr Gly Leu Asp 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR1 (Chothia)

<400>  94

Ser Gln Ser Val Ser Ser Ala 
1               5           


<210>  95
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR3 (Chothia)

<400>  95

Tyr Tyr Thr Ser Pro Tyr 
1               5       


<210>  96
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR1 (Contact)

<400>  96

Ser Ser Tyr Tyr Ile His 
1               5       


<210>  97
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR2 (Contact)

<400>  97

Trp Val Ala Trp Ile Thr Ser His Gly Tyr Ser Thr Lys 
1               5                   10              


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR3 (Contact)

<400>  98

Ala Arg Asp Ser Val Ile Tyr Gly Leu Asp 
1               5                   10  


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR1 (Contact)

<400>  99

Ser Ser Ala Val Ala Trp Tyr 
1               5           


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR2 (Contact)

<400>  100

Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr 
1               5                   10  


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL CDR3 (Contact)

<400>  101

Gln Gln Tyr Tyr Thr Ser Pro Tyr 
1               5               


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH CDR2 (AbM)

<400>  102

Trp Ile Thr Ser His Gly Tyr Ser Thr Lys 
1               5                   10  


<210>  103
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VH Sequence

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Thr Ser His Gly Tyr Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Val Ile Tyr Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr 
        115 


<210>  104
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P22 VL Sequence

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR1 (Exemplary, AbM)

<400>  105

Gly Phe Thr Phe Asp Gln Tyr Tyr Ile His 
1               5                   10  


<210>  106
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR2 (Exemplary, Kabat)

<400>  106

Glu Ile Tyr Pro Ala Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR3 (Exemplary, Kabat, AbM)

<400>  107

Gly Pro Tyr Ser Val Arg Tyr Ala Leu Asp Tyr 
1               5                   10      


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR1 (Exemplary, Kabat, AbM)

<400>  108

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR2 (Exemplary, Kabat, AbM)

<400>  109

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  110
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  110

Gln Gln Val Ser Tyr Ser Pro Tyr Thr 
1               5                   


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR1 (IMGT)

<400>  111

Gly Phe Thr Phe Asp Gln Tyr Tyr 
1               5               


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR2 (IMGT)

<400>  112

Ile Tyr Pro Ala Gly Ser Tyr Thr 
1               5               


<210>  113
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR3 (IMGT)

<400>  113

Ala Arg Gly Pro Tyr Ser Val Arg Tyr Ala Leu Asp Tyr 
1               5                   10              


<210>  114
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR1 (IMGT)

<400>  114

Gln Ser Val Ser Ser Ala 
1               5       


<210>  115
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR2 (IMGT, Chothia)

<400>  115

Ser Ala Ser 
1           


<210>  116
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR1 (Kabat)

<400>  116

Gln Tyr Tyr Ile His 
1               5   


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR1 (Chothia)

<400>  117

Gly Phe Thr Phe Asp Gln Tyr 
1               5           


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR2 (Chothia)

<400>  118

Pro Ala Gly Ser 
1               


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR3 (Chothia)

<400>  119

Pro Tyr Ser Val Arg Tyr Ala Leu Asp 
1               5                   


<210>  120
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR1 (Chothia)

<400>  120

Ser Gln Ser Val Ser Ser Ala 
1               5           


<210>  121
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR3 (Chothia)

<400>  121

Val Ser Tyr Ser Pro Tyr 
1               5       


<210>  122
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR1 (Contact)

<400>  122

Asp Gln Tyr Tyr Ile His 
1               5       


<210>  123
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR2 (Contact)

<400>  123

Trp Val Ala Glu Ile Tyr Pro Ala Gly Ser Tyr Thr Tyr 
1               5                   10              


<210>  124
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR3 (Contact)

<400>  124

Ala Arg Gly Pro Tyr Ser Val Arg Tyr Ala Leu Asp 
1               5                   10          


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR1 (Contact)

<400>  125

Ser Ser Ala Val Ala Trp Tyr 
1               5           


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR2 (Contact)

<400>  126

Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr 
1               5                   10  


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL CDR3 (Contact)

<400>  127

Gln Gln Val Ser Tyr Ser Pro Tyr 
1               5               


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH CDR2 (AbM)

<400>  128

Glu Ile Tyr Pro Ala Gly Ser Tyr Thr Tyr 
1               5                   10  


<210>  129
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VH Sequence

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gln Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Tyr Pro Ala Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Tyr Ser Val Arg Tyr Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr 
        115         


<210>  130
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P24 VL Sequence

<400>  130

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Ser Tyr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR1 (Exemplary, AbM)

<400>  131

Gly Phe Thr Phe Ser Ser Tyr Tyr Ile His 
1               5                   10  


<210>  132
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR2 (Exemplary, Kabat)

<400>  132

Thr Ile Ser Ser Gly Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR3 (Exemplary, Kabat, AbM)

<400>  133

Gly Tyr Thr Leu Thr Pro Val Leu Asp Tyr 
1               5                   10  


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR1 (Exemplary, Kabat, AbM)

<400>  134

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR2 (Exemplary, Kabat, AbM)

<400>  135

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  136

Gln Gln Phe Gly Ala Glu Pro Ile Thr 
1               5                   


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR1 (IMGT)

<400>  137

Gly Phe Thr Phe Ser Ser Tyr Tyr 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR2 (IMGT)

<400>  138

Ile Ser Ser Gly Gly Gly Phe Thr 
1               5               


<210>  139
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR3 (IMGT)

<400>  139

Ala Arg Gly Tyr Thr Leu Thr Pro Val Leu Asp Tyr 
1               5                   10          


<210>  140
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR1 (IMGT)

<400>  140

Gln Ser Val Ser Ser Ala 
1               5       


<210>  141
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR2 (IMGT, Chothia)

<400>  141

Ser Ala Ser 
1           


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR1 (Kabat)

<400>  142

Ser Tyr Tyr Ile His 
1               5   


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR1 (Chothia)

<400>  143

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  144
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR2 (Chothia)

<400>  144

Ser Gly Gly Gly 
1               


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR3 (Chothia)

<400>  145

Tyr Thr Leu Thr Pro Val Leu Asp 
1               5               


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR1 (Chothia)

<400>  146

Ser Gln Ser Val Ser Ser Ala 
1               5           


<210>  147
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR3 (Chothia)

<400>  147

Phe Gly Ala Glu Pro Ile 
1               5       


<210>  148
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR1 (Contact)

<400>  148

Ser Ser Tyr Tyr Ile His 
1               5       


<210>  149
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR2 (Contact)

<400>  149

Trp Val Ala Thr Ile Ser Ser Gly Gly Gly Phe Thr Tyr 
1               5                   10              


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR3 (Contact)

<400>  150

Ala Arg Gly Tyr Thr Leu Thr Pro Val Leu Asp 
1               5                   10      


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR1 (Contact)

<400>  151

Ser Ser Ala Val Ala Trp Tyr 
1               5           


<210>  152
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR2 (Contact)

<400>  152

Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr 
1               5                   10  


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL CDR3 (Contact)

<400>  153

Gln Gln Phe Gly Ala Glu Pro Ile 
1               5               


<210>  154
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH CDR2 (AbM)

<400>  154

Thr Ile Ser Ser Gly Gly Gly Phe Thr Tyr 
1               5                   10  


<210>  155
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VH Sequence

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Thr Leu Thr Pro Val Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr 
        115     


<210>  156
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody P31.2 VL Sequence

<400>  156

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Gly Ala Glu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  157
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C40 First polypeptide chain (BC1)

<400>  157

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Tyr Ser Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  158
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C40 Second polypeptide chain (BC1)

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Asp Pro Tyr Gly His Ser Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Asp 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly Glu Cys 
    210                 215                 220                 


<210>  159
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P22 Third polypeptide chain (BC1 and B44)

<400>  159

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  160
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P22 Fourth polypeptide chain (BC1 and BC44)

<400>  160

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Thr Ser His Gly Tyr Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Val Ile Tyr Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Pro Lys Ser Cys 
    210                 215                 220         


<210>  161
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P24 Third polypeptide chain (BC1 and BC44)

<400>  161

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Ser Tyr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  162
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P24 Fourth polypeptide chain (BC1 and BC44)

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gln Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Tyr Pro Ala Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Tyr Ser Val Arg Tyr Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Pro Lys Ser Cys 
    210                 215                 220                 


<210>  163
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P31.2 Third polypeptide chain (BC1 and BC44)

<400>  163

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Gly Ala Glu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  164
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P31.2 Fourth polypeptide chain (BC1)

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Thr Leu Thr Pro Val Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Pro Lys Ser Cys 
    210                 215                 220             


<210>  165
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C56 First polypeptide chain (BC1)

<400>  165

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Ser Asp Leu Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  166
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C56 Second polypeptide chain (BC1)

<400>  166

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Tyr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Asp Pro Tyr Ser Gly Ser Thr Glu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Asp 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly Glu Cys 
    210                 215                 220                 


<210>  167
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C59 First polypeptide chain (BC1)

<400>  167

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Thr Thr Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  168
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C59 Second polypeptide chain (BC1)

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Lys His Gly Thr Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Asp 
        115                 120                 125             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly Glu Cys 
    210                 215                 220                 


<210>  169
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C40 First polypeptide chain (BC1; silent Fc)

<400>  169

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Tyr Ser Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  170
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P22 Third polypeptide chain (BC1; silent Fc and BC44; silent Fc)

<400>  170

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  171
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P24 Third polypeptide chain (BC1; silent Fc and BC44; silent Fc)

<400>  171

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Ser Tyr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  172
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P31.2 Third polypeptide chain (BC1; silent Fc and BC44; silent 
       Fc)

<400>  172

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Gly Ala Glu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  173
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C56 First polypeptide chain (BC1; silent Fc)

<400>  173

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Ser Asp Leu Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  174
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C59 First polypeptide chain (BC1; silent Fc)

<400>  174

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Thr Thr Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Pro Arg Glu 
            100                 105                 110         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  175
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C40 First polypeptide chain (BC44)

<400>  175

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Tyr Ser Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Arg Glu 
            100                 105                 110         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  176
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C40 Second polypeptide chain (BC44)

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Asp Pro Tyr Gly His Ser Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  177
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C56 First polypeptide chain (BC44)

<400>  177

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Ser Asp Leu Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Arg Glu 
            100                 105                 110         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  178
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C56 Second polypeptide chain (BC44)

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Tyr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Asp Pro Tyr Ser Gly Ser Thr Glu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  179
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C59 First polypeptide chain (BC44)

<400>  179

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Thr Thr Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Arg Glu 
            100                 105                 110         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  180
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C59 Second polypeptide chain (BC44)

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asp Ser Lys His Gly Thr Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  181
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C40 First polypeptide chain (BC44; silent Fc)

<400>  181

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Tyr Ser Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Arg Glu 
            100                 105                 110         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  182
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C56 First polypeptide chain (BC44; silent Fc)

<400>  182

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Ser Asp Leu Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Arg Glu 
            100                 105                 110         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  183
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C59 First polypeptide chain (BC44; silent Fc)

<400>  183

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Thr Thr Ser Leu Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Arg Glu 
            100                 105                 110         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        115                 120                 125             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    130                 135                 140                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
145                 150                 155                 160 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            180                 185                 190         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        195                 200                 205             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  184
<211>  323
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-length amino acid sequence of human CD47

<400>  184

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  185
<211>  504
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-length amino acid sequence of human SIRPa

<400>  185

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  186
<211>  290
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-length amino acid sequence of human PD-L1

<400>  186

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  187
<211>  288
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-length amino acid sequence of human PD-1

<400>  187

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  188
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Fc region sequence

<400>  188

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  189
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary variant Fc region (silent Fc) sequence

<400>  189

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  190
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary variant CH2 domain (e.g., silent CH2) sequence

<400>  190

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  191
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary IgG heavy chain comprises any VH domain

<400>  191

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  192
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary IgG heavy chain comprises any VH domain

<400>  192

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Lys Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  193
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary light chain (e.g., for pairing with an IgG heavy chain)
       comprises any VL domain

<400>  193

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  194
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VH CDR1


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  194

Gly Phe Thr Phe Xaa Xaa Tyr Tyr Ile His 
1               5                   10  


<210>  195
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VH CDR2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  195

Xaa Ile Asp Xaa Xaa Xaa Xaa Xaa Thr Xaa Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  196
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VH CDR3


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  196

Gly Gly Xaa Xaa Ala Xaa Asp Tyr 
1               5               


<210>  197
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 and PD-L1 VL CDR1

<400>  197

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 and PD-L1 VL CDR2

<400>  198

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  199
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VL CDR3


<220>
<221>  misc_feature
<222>  (3)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  199

Gln Gln Xaa Xaa Xaa Xaa Leu Xaa Thr 
1               5                   


<210>  200
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VH CDR1


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  200

Gly Phe Thr Phe Xaa Xaa Tyr Tyr Ile His 
1               5                   10  


<210>  201
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VH CDR2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  201

Xaa Ile Xaa Xaa Xaa Gly Xaa Xaa Thr Xaa Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  202
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VH CDR3


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  202

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Asp Tyr 
1               5                   10      


<210>  203
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VL CDR3


<220>
<221>  misc_feature
<222>  (3)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  203

Gln Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  204
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phage display heavy chain


<220>
<221>  misc_feature
<222>  (31)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (50)..(66)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (99)..(112)
<223>  Xaa can be any naturally occurring amino acid

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys 
225     


<210>  205
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phage display light chain


<220>
<221>  misc_feature
<222>  (89)..(97)
<223>  Xaa can be any naturally occurring amino acid

<400>  205

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  206
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VH CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is a W, F or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a P or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a Y or K

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a G, S or H

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a H or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is a S or T

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a T, E or Q

<400>  206

Xaa Ile Asp Xaa Xaa Xaa Xaa Xaa Thr Xaa Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  207
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VH CDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a R or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a G, Y or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a M or L

<400>  207

Gly Gly Xaa Xaa Ala Xaa Asp Tyr 
1               5               


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VL CDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a R or G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a Y, R or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a S or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a S or D

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is a L or R

<400>  208

Gln Gln Xaa Xaa Xaa Xaa Leu Xaa Thr 
1               5                   


<210>  209
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VH CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is a E, W, or T

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a Y, T, or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a P or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a A, H, or G

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a S, Y, or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is a Y, S, or F

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a Y or K

<400>  209

Xaa Ile Xaa Xaa Xaa Gly Xaa Xaa Thr Xaa Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  210
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VH CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is a G or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is a P, S, or Y

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a Y, V, or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a S, I, or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a V, Y, or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a R, G or P

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a Y or V (or not present)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is an A (or not present)

<400>  210

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Asp Tyr 
1               5                   10      


<210>  211
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VL CDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a V, Y, or F

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a S, Y, or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a Y, T, or A

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a S or E

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is a Y or I

<400>  211

Gln Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  212
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VH consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a S or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a Y or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is a W, F or Y

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is a P or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is a Y or K

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is a G, S or H

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is a H or G

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is a S or T

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is a T, E or Q

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is a R or L

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is a G, Y or S

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is a M or L

<400>  212

Gly Phe Thr Phe Xaa Xaa Tyr Tyr Ile His Xaa Ile Asp Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Thr Xaa Tyr Ala Asp Ser Val Lys Gly Gly Gly Xaa Xaa Ala 
            20                  25                  30          


Xaa Asp Tyr 
        35  


<210>  213
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VL consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is a R or G

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is a Y, R or T

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is a S or T

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is a S or D

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is a L or R

<400>  213

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Ser Ala Ser Ser Leu 
1               5                   10                  15      


Tyr Ser Gln Gln Xaa Xaa Xaa Xaa Leu Xaa Thr 
            20                  25          


<210>  214
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VH consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a D or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a Q or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is a E, W, or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is a Y, T, or S

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is a P or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is a A, H, or G

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is a S, Y, or G

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is a Y, S, or F

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is a Y or K

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is a G or D

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  X is a P, S, or Y

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is a Y, V, or T

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is a S, I, or L

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is a V, Y, or T

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is a R, G or P

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is a Y or V (or not present)

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  X is an A (or not present)

<400>  214

Gly Phe Thr Phe Xaa Xaa Tyr Tyr Ile His Xaa Ile Xaa Xaa Xaa Gly 
1               5                   10                  15      


Xaa Xaa Thr Xaa Tyr Ala Asp Ser Val Lys Gly Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Leu Asp Tyr 
        35              


<210>  215
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VL consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is a V, Y, or F

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is a S, Y, or G

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is a Y, T, or A

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is a S or E

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is a Y or I

<400>  215

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Ser Ala Ser Ser Leu 
1               5                   10                  15      


Tyr Ser Gln Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
            20                  25          


<210>  216
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47 VH CDR1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a S or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a Y or S

<400>  216

Gly Phe Thr Phe Xaa Xaa Tyr Tyr Ile His 
1               5                   10  


<210>  217
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 VH CDR1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a D or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a Q or S

<400>  217

Gly Phe Thr Phe Xaa Xaa Tyr Tyr Ile His 
1               5                   10  




