                         SEQUENCE LISTING

<110>  Kyverna Therapeutics, Inc.
 
<120>  METHODS OF PRODUCING T REGULATORY CELLS, METHODS OF TRANSDUCING T
        CELLS, AND USES OF THE SAME

<130>  47902-0028W01

<150>  US 63/060,388
<151>  2020-08-03

<150>  US 63/158,722
<151>  2021-03-09

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CD28 target sequence 1

<400>  1
caaccttagc tgcaagtatt c                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CD28 target sequence 2

<400>  2
tggagtcctg gcttgctata g                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CD28 target sequence 3

<400>  3
cctcctcctt acctagacaa t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CD28 target sequence 4

<400>  4
gctgtggaag tctgtgttgt a                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CD28 target sequence 5

<400>  5
cgcaagcatt accagcccta t                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CD28 target sequence 6

<400>  6
cttcaattca agtaacagga a                                                 21


<210>  7
<211>  2264
<212>  DNA
<213>  Human

<400>  7
agtttcccac aagccaggct gatccttttc tgtcagtcca cttcaccaag cctgcccttg       60

gacaaggacc cgatgcccaa ccccaggcct ggcaagccct cggccccttc cttggccctt      120

ggcccatccc caggagcctc gcccagctgg agggctgcac ccaaagcctc agacctgctg      180

ggggcccggg gcccaggggg aaccttccag ggccgagatc ttcgaggcgg ggcccatgcc      240

tcctcttctt ccttgaaccc catgccacca tcgcagctgc agctgcccac actgccccta      300

gtcatggtgg caccctccgg ggcacggctg ggccccttgc cccacttaca ggcactcctc      360

caggacaggc cacatttcat gcaccagctc tcaacggtgg atgcccacgc ccggacccct      420

gtgctgcagg tgcaccccct ggagagccca gccatgatca gcctcacacc acccaccacc      480

gccactgggg tcttctccct caaggcccgg cctggcctcc cacctgggat caacgtggcc      540

agcctggaat gggtgtccag ggagccggca ctgctctgca ccttcccaaa tcccagtgca      600

cccaggaagg acagcaccct ttcggctgtg ccccagagct cctacccact gctggcaaat      660

ggtgtctgca agtggcccgg atgtgagaag gtcttcgaag agccagagga cttcctcaag      720

cactgccagg cggaccatct tctggatgag aagggcaggg cacaatgtct cctccagaga      780

gagatggtac agtctctgga gcagcagctg gtgctggaga aggagaagct gagtgccatg      840

caggcccacc tggctgggaa aatggcactg accaaggctt catctgtggc atcatccgac      900

aagggctcct gctgcatcgt agctgctggc agccaaggcc ctgtcgtccc agcctggtct      960

ggcccccggg aggcccctga cagcctgttt gctgtccgga ggcacctgtg gggtagccat     1020

ggaaacagca cattcccaga gttcctccac aacatggact acttcaagtt ccacaacatg     1080

cgaccccctt tcacctacgc cacgctcatc cgctgggcca tcctggaggc tccagagaag     1140

cagcggacac tcaatgagat ctaccactgg ttcacacgca tgtttgcctt cttcagaaac     1200

catcctgcca cctggaagaa cgccatccgc cacaacctga gtctgcacaa gtgctttgtg     1260

cgggtggaga gcgagaaggg ggctgtgtgg accgtggatg agctggagtt ccgcaagaaa     1320

cggagccaga ggcccagcag gtgttccaac cctacacctg gcccctgacc tcaagatcaa     1380

ggaaaggagg atggacgaac aggggccaaa ctggtgggag gcagaggtgg tgggggcagg     1440

gatgataggc cctggatgtg cccacaggga ccaagaagtg aggtttccac tgtcttgcct     1500

gccagggccc ctgttccccc gctggcagcc accccctccc ccatcatatc ctttgcccca     1560

aggctgctca gaggggcccc ggtcctggcc ccagccccca cctccgcccc agacacaccc     1620

cccagtcgag ccctgcagcc aaacagagcc ttcacaacca gccacacaga gcctgcctca     1680

gctgctcgca cagattactt cagggctgga aaagtcacac agacacacaa aatgtcacaa     1740

tcctgtccct cactcaacac aaaccccaaa acacagagag cctgcctcag tacactcaaa     1800

caacctcaaa gctgcatcat cacacaatca cacacaagca cagccctgac aacccacaca     1860

ccccaaggca cgcacccaca gccagcctca gggcccacag gggcactgtc aacacagggg     1920

tgtgcccaga ggcctacaca gaagcagcgt cagtaccctc aggatctgag gtcccaacac     1980

gtgctcgctc acacacacgg cctgttagaa ttcacctgtg tatctcacgc atatgcacac     2040

gcacagcccc ccagtgggtc tcttgagtcc cgtgcagaca cacacagcca cacacactgc     2100

cttgccaaaa ataccccgtg tctcccctgc cactcacctc actcccattc cctgagccct     2160

gatccatgcc tcagcttaga ctgcagagga actactcatt tatttgggat ccaaggcccc     2220

caacccacag taccgtcccc aataaactgc agccgagctc ccca                      2264


<210>  8
<211>  431
<212>  PRT
<213>  Human

<400>  8

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  9
<211>  876
<212>  DNA
<213>  Human

<400>  9
atggccacaa ccatggacgg gccgcgcctg ctgctgttgc tgcttctggg ggtgtccctt       60

ggaggtgcca aggaggcatg ccccacaggc ctgtacacac acagcggtga gtgctgcaaa      120

gcctgcaacc tgggcgaggg tgtggcccag ccttgtggag ccaaccagac cgtgtgtgag      180

ccctgcctgg acagcgtgac gttctccgac gtggtgagcg cgaccgagcc gtgcaagccg      240

tgcaccgagt gcgtggggct ccagagcatg tcggcgccgt gcgtggaggc cgacgacgcc      300

gtgtgccgct gcgcctacgg ctactaccag gatgagacga ctgggcgctg cgaggcgtgc      360

cgcgtgtgcg aggcgggctc gggcctcgtg ttctcctgcc aggacaagca gaacaccgtg      420

tgcgaggagt gccccgacgg cacgtattcc gacgaggcca accacgtgga cccgtgcctg      480

ccctgcaccg tgtgcgagga caccgagcgc cagctccgcg agtgcacacg ctgggccgac      540

gccgagtgcg aggagatccc tggccgttgg attacacggt ccacaccccc agagggctcg      600

gacagcacag cccccagcac ccaggagcct gaggcacctc cagaacaaga cctcatagcc      660

agcacggtgg caggtgtggt gaccacagtg atgggcagct cccagcccgt ggtgacccga      720

ggcaccaccg acaacctcat ccctgtctat tgctccatcc tggctgctgt ggttgtgggc      780

cttgtggcct acatagcctt caagaggtgg aacagtcatc gatatcctcg aggtcaccgc      840

ggtctagagt cgacctgcag ccaagcttat cgataa                                876


<210>  10
<211>  277
<212>  PRT
<213>  Human

<400>  10

Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 
            20                  25                  30          


Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn 
        35                  40                  45              


Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 
    50                  55                  60                  


Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 
65                  70                  75                  80  


Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 
                85                  90                  95      


Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 
            100                 105                 110         


Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 
        115                 120                 125             


Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 
    130                 135                 140                 


Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 
145                 150                 155                 160 


Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 
                165                 170                 175     


Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 
            180                 185                 190         


Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 
        195                 200                 205             


Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 
    210                 215                 220                 


Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln 
225                 230                 235                 240 


Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 
                245                 250                 255     


Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 
            260                 265                 270         


Lys Arg Trp Asn Ser 
        275         


<210>  11
<211>  220
<212>  PRT
<213>  Human

<400>  11

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  12
<211>  4430
<212>  DNA
<213>  Human

<400>  12
acacttcggg ttcctcgggg aggaggggct ggaaccctag cccatcgtca ggacaaagat       60

gctcaggctg ctcttggctc tcaacttatt cccttcaatt caagtaacag gaaacaagat      120

tttggtgaag cagtcgccca tgcttgtagc gtacgacaat gcggtcaacc ttagctggaa      180

acacctttgt ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt      240

ggttggtgga gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg      300

ggtgaggagt aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg      360

ccccgggccc acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta      420

tcgctcctga cacggacgcc tatccagaag ccagccggct ggcagccccc atctgctcaa      480

tatcactgct ctggatagga aatgaccgcc atctccagcc ggccacctca ggcccctgtt      540

gggccaccaa tgccaatttt tctcgagtga ctagaccaaa tatcaagatc attttgagac      600

tctgaaatga agtaaaagag atttcctgtg acaggccaag tcttacagtg ccatggccca      660

cattccaact taccatgtac ttagtgactt gactgagaag ttagggtaga aaacaaaaag      720

ggagtggatt ctgggagcct cttccctttc tcactcacct gcacatctca gtcaagcaaa      780

gtgtggtatc cacagacatt ttagttgcag aagaaaggct aggaaatcat tccttttggt      840

taaatgggtg tttaatcttt tggttagtgg gttaaacggg gtaagttaga gtagggggag      900

ggataggaag acatatttaa aaaccattaa aacactgtct cccactcatg aaatgagcca      960

cgtagttcct atttaatgct gttttccttt agtttagaaa tacatagaca ttgtctttta     1020

tgaattctga tcatatttag tcattttgac caaatgaggg atttggtcaa atgagggatt     1080

ccctcaaagc aatatcaggt aaaccaagtt gctttcctca ctccctgtca tgagacttca     1140

gtgttaatgt tcacaatata ctttcgaaag aataaaatag ttctcctaca tgaagaaaga     1200

atatgtcagg aaataaggtc actttatgtc aaaattattt gagtactatg ggacctggcg     1260

cagtggctca tgcttgtaat cccagcactt tgggaggccg aggtgggcag atcacttgag     1320

atcaggacca gcctggtcaa gatggtgaaa ctccgtctgt actaaaaata caaaatttag     1380

cttggcctgg tggcaggcac ctgtaatccc agctgcccaa gaggctgagg catgagaatc     1440

gcttgaacct ggcaggcgga ggttgcagtg agccgagata gtgccacagc tctccagcct     1500

gggcgacaga gtgagactcc atctcaaaca acaacaacaa caacaacaac aacaacaaac     1560

cacaaaatta tttgagtact gtgaaggatt atttgtctaa cagttcattc caatcagacc     1620

aggtaggagc tttcctgttt catatgtttc agggttgcac agttggtctc tttaatgtcg     1680

gtgtggagat ccaaagtggg ttgtggaaag agcgtccata ggagaagtga gaatactgtg     1740

aaaaagggat gttagcattc attagagtat gaggatgagt cccaagaagg ttctttggaa     1800

ggaggacgaa tagaatggag taatgaaatt cttgccatgt gctgaggaga tagccagcat     1860

taggtgacaa tcttccagaa gtggtcaggc agaaggtgcc ctggtgagag ctcctttaca     1920

gggactttat gtggtttagg gctcagagct ccaaaactct gggctcagct gctcctgtac     1980

cttggaggtc cattcacatg ggaaagtatt ttggaatgtg tcttttgaag agagcatcag     2040

agttcttaag ggactgggta aggcctgacc ctgaaatgac catggatatt tttctaccta     2100

cagtttgagt caactagaat atgcctgggg accttgaaga atggcccttc agtggccctc     2160

accatttgtt catgcttcag ttaattcagg tgttgaagga gcttaggttt tagaggcacg     2220

tagacttggt tcaagtctcg ttagtagttg aatagcctca ggcaagtcac tgcccaccta     2280

agatgatggt tcttcaacta taaaatggag ataatggtta caaatgtctc ttcctatagt     2340

ataatctcca taagggcatg gcccaagtct gtctttgact ctgcctatcc ctgacattta     2400

gtagcatgcc cgacatacaa tgttagctat tggtattatt gccatataga taaattatgt     2460

ataaaaatta aactgggcaa tagcctaaga aggggggaat attgtaacac aaatttaaac     2520

ccactacgca gggatgaggt gctataatat gaggaccttt taacttccat cattttcctg     2580

tttcttgaaa tagtttatct tgtaatgaaa tataaggcac ctcccacttt tatgtataga     2640

aagaggtctt ttaatttttt tttaatgtga gaaggaaggg aggagtagga atcttgagat     2700

tccagatcga aaatactgta ctttggttga tttttaagtg ggcttccatt ccatggattt     2760

aatcagtccc aagaagatca aactcagcag tacttgggtg ctgaagaact gttggattta     2820

ccctggcacg tgtgccactt gccagcttct tgggcacaca gagttcttca atccaagtta     2880

tcagattgta tttgaaaatg acagagctgg agagtttttt gaaatggcag tggcaaataa     2940

ataaatactt ttttttaaat ggaaagactt gatctatggt aataaatgat tttgttttct     3000

gactggaaaa ataggcctac taaagatgaa tcacacttga gatgtttctt actcactctg     3060

cacagaaaca aagaagaaat gttatacagg gaagtccgtt ttcactatta gtatgaacca     3120

agaaatggtt caaaaacagt ggtaggagca atgctttcat agtttcagat atggtagtta     3180

tgaagaaaac aatgtcattt gctgctatta ttgtaagagt cttataatta atggtactcc     3240

tataattttt gattgtgagc tcacctattt gggttaagca tgccaattta aagagaccaa     3300

gtgtatgtac attatgttct acatattcag tgataaaatt actaaactac tatatgtctg     3360

ctttaaattt gtactttaat attgtctttt ggtattaaga aagatatgct ttcagaatag     3420

atatgcttcg ctttggcaag gaatttggat agaacttgct atttaaaaga ggtgtggggt     3480

aaatccttgt ataaatctcc agtttagcct tttttgaaaa agctagactt tcaaatacta     3540

atttcacttc aagcagggta cgtttctggt ttgtttgctt gacttcagtc acaatttctt     3600

atcagaccaa tggctgacct ctttgagatg tcaggctagg cttacctatg tgttctgtgt     3660

catgtgaatg ctgagaagtt tgacagagat ccaacttcag ccttgacccc atcagtccct     3720

cgggttaact aactgagcca ccggtcctca tggctatttt aatgagggta ttgatggtta     3780

aatgcatgtc tgatccctta tcccagccat ttgcactgcc agctgggaac tataccagac     3840

ctggatactg atcccaaagt gttaaattca actacatgct ggagattaga gatggtgcca     3900

ataaaggacc cagaaccagg atcttgattg ctatagactt attaataatc caggtcaaag     3960

agagtgacac acactctctc aagacctggg gtgagggagt ctgtgttatc tgcaaggcca     4020

tttgaggctc agaaagtctc tctttcctat agatatatgc atactttctg acatatagga     4080

atgtatcagg aatactcaac catcacaggc atgttcctac ctcagggcct ttacatgtcc     4140

tgtttactct gtctagaatg tccttctgta gatgacctgg cttgcctcgt cacccttcag     4200

gtccttgctc aagtgtcatc ttctccccta gttaaactac cccacaccct gtctgctttc     4260

cttgcttatt tttctccata gcattttacc atctcttaca ttagacattt ttcttattta     4320

tttgtagttt ataagcttca tgaggcaagt aactttgctt tgtttcttgc tgtatctcca     4380

gtgcccagag cagtgcctgg tatataataa atatttattg actgagtgaa                4430


<210>  13
<211>  4543
<212>  DNA
<213>  Human

<400>  13
taaagtcatc aaaacaacgt tatatcctgt gtgaaatgct gcagtcagga tgccttgtgg       60

tttgagtgcc ttgatcatgt gccctaaggg gatggtggcg gtggtggtgg ccgtggatga      120

cggagactct caggccttgg caggtgcgtc tttcagttcc cctcacactt cgggttcctc      180

ggggaggagg ggctggaacc ctagcccatc gtcaggacaa agatgctcag gctgctcttg      240

gctctcaact tattcccttc aattcaagta acagggaaac acctttgtcc aagtccccta      300

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      360

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      420

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      480

taccagccct atgccccacc acgcgacttc gcagcctatc gctcctgaca cggacgccta      540

tccagaagcc agccggctgg cagcccccat ctgctcaata tcactgctct ggataggaaa      600

tgaccgccat ctccagccgg ccacctcagg cccctgttgg gccaccaatg ccaatttttc      660

tcgagtgact agaccaaata tcaagatcat tttgagactc tgaaatgaag taaaagagat      720

ttcctgtgac aggccaagtc ttacagtgcc atggcccaca ttccaactta ccatgtactt      780

agtgacttga ctgagaagtt agggtagaaa acaaaaaggg agtggattct gggagcctct      840

tccctttctc actcacctgc acatctcagt caagcaaagt gtggtatcca cagacatttt      900

agttgcagaa gaaaggctag gaaatcattc cttttggtta aatgggtgtt taatcttttg      960

gttagtgggt taaacggggt aagttagagt agggggaggg ataggaagac atatttaaaa     1020

accattaaaa cactgtctcc cactcatgaa atgagccacg tagttcctat ttaatgctgt     1080

tttcctttag tttagaaata catagacatt gtcttttatg aattctgatc atatttagtc     1140

attttgacca aatgagggat ttggtcaaat gagggattcc ctcaaagcaa tatcaggtaa     1200

accaagttgc tttcctcact ccctgtcatg agacttcagt gttaatgttc acaatatact     1260

ttcgaaagaa taaaatagtt ctcctacatg aagaaagaat atgtcaggaa ataaggtcac     1320

tttatgtcaa aattatttga gtactatggg acctggcgca gtggctcatg cttgtaatcc     1380

cagcactttg ggaggccgag gtgggcagat cacttgagat caggaccagc ctggtcaaga     1440

tggtgaaact ccgtctgtac taaaaataca aaatttagct tggcctggtg gcaggcacct     1500

gtaatcccag ctgcccaaga ggctgaggca tgagaatcgc ttgaacctgg caggcggagg     1560

ttgcagtgag ccgagatagt gccacagctc tccagcctgg gcgacagagt gagactccat     1620

ctcaaacaac aacaacaaca acaacaacaa caacaaacca caaaattatt tgagtactgt     1680

gaaggattat ttgtctaaca gttcattcca atcagaccag gtaggagctt tcctgtttca     1740

tatgtttcag ggttgcacag ttggtctctt taatgtcggt gtggagatcc aaagtgggtt     1800

gtggaaagag cgtccatagg agaagtgaga atactgtgaa aaagggatgt tagcattcat     1860

tagagtatga ggatgagtcc caagaaggtt ctttggaagg aggacgaata gaatggagta     1920

atgaaattct tgccatgtgc tgaggagata gccagcatta ggtgacaatc ttccagaagt     1980

ggtcaggcag aaggtgccct ggtgagagct cctttacagg gactttatgt ggtttagggc     2040

tcagagctcc aaaactctgg gctcagctgc tcctgtacct tggaggtcca ttcacatggg     2100

aaagtatttt ggaatgtgtc ttttgaagag agcatcagag ttcttaaggg actgggtaag     2160

gcctgaccct gaaatgacca tggatatttt tctacctaca gtttgagtca actagaatat     2220

gcctggggac cttgaagaat ggcccttcag tggccctcac catttgttca tgcttcagtt     2280

aattcaggtg ttgaaggagc ttaggtttta gaggcacgta gacttggttc aagtctcgtt     2340

agtagttgaa tagcctcagg caagtcactg cccacctaag atgatggttc ttcaactata     2400

aaatggagat aatggttaca aatgtctctt cctatagtat aatctccata agggcatggc     2460

ccaagtctgt ctttgactct gcctatccct gacatttagt agcatgcccg acatacaatg     2520

ttagctattg gtattattgc catatagata aattatgtat aaaaattaaa ctgggcaata     2580

gcctaagaag gggggaatat tgtaacacaa atttaaaccc actacgcagg gatgaggtgc     2640

tataatatga ggacctttta acttccatca ttttcctgtt tcttgaaata gtttatcttg     2700

taatgaaata taaggcacct cccactttta tgtatagaaa gaggtctttt aatttttttt     2760

taatgtgaga aggaagggag gagtaggaat cttgagattc cagatcgaaa atactgtact     2820

ttggttgatt tttaagtggg cttccattcc atggatttaa tcagtcccaa gaagatcaaa     2880

ctcagcagta cttgggtgct gaagaactgt tggatttacc ctggcacgtg tgccacttgc     2940

cagcttcttg ggcacacaga gttcttcaat ccaagttatc agattgtatt tgaaaatgac     3000

agagctggag agttttttga aatggcagtg gcaaataaat aaatactttt ttttaaatgg     3060

aaagacttga tctatggtaa taaatgattt tgttttctga ctggaaaaat aggcctacta     3120

aagatgaatc acacttgaga tgtttcttac tcactctgca cagaaacaaa gaagaaatgt     3180

tatacaggga agtccgtttt cactattagt atgaaccaag aaatggttca aaaacagtgg     3240

taggagcaat gctttcatag tttcagatat ggtagttatg aagaaaacaa tgtcatttgc     3300

tgctattatt gtaagagtct tataattaat ggtactccta taatttttga ttgtgagctc     3360

acctatttgg gttaagcatg ccaatttaaa gagaccaagt gtatgtacat tatgttctac     3420

atattcagtg ataaaattac taaactacta tatgtctgct ttaaatttgt actttaatat     3480

tgtcttttgg tattaagaaa gatatgcttt cagaatagat atgcttcgct ttggcaagga     3540

atttggatag aacttgctat ttaaaagagg tgtggggtaa atccttgtat aaatctccag     3600

tttagccttt tttgaaaaag ctagactttc aaatactaat ttcacttcaa gcagggtacg     3660

tttctggttt gtttgcttga cttcagtcac aatttcttat cagaccaatg gctgacctct     3720

ttgagatgtc aggctaggct tacctatgtg ttctgtgtca tgtgaatgct gagaagtttg     3780

acagagatcc aacttcagcc ttgaccccat cagtccctcg ggttaactaa ctgagccacc     3840

ggtcctcatg gctattttaa tgagggtatt gatggttaaa tgcatgtctg atcccttatc     3900

ccagccattt gcactgccag ctgggaacta taccagacct ggatactgat cccaaagtgt     3960

taaattcaac tacatgctgg agattagaga tggtgccaat aaaggaccca gaaccaggat     4020

cttgattgct atagacttat taataatcca ggtcaaagag agtgacacac actctctcaa     4080

gacctggggt gagggagtct gtgttatctg caaggccatt tgaggctcag aaagtctctc     4140

tttcctatag atatatgcat actttctgac atataggaat gtatcaggaa tactcaacca     4200

tcacaggcat gttcctacct cagggccttt acatgtcctg tttactctgt ctagaatgtc     4260

cttctgtaga tgacctggct tgcctcgtca cccttcaggt ccttgctcaa gtgtcatctt     4320

ctcccctagt taaactaccc cacaccctgt ctgctttcct tgcttatttt tctccatagc     4380

attttaccat ctcttacatt agacattttt cttatttatt tgtagtttat aagcttcatg     4440

aggcaagtaa ctttgctttg tttcttgctg tatctccagt gcccagagca gtgcctggta     4500

tataataaat atttattgac tgagtgaaaa aaaaaaaaaa aaa                       4543


<210>  14
<211>  4721
<212>  DNA
<213>  Human

<400>  14
acacttcggg ttcctcgggg aggaggggct ggaaccctag cccatcgtca ggacaaagat       60

gctcaggctg ctcttggctc tcaacttatt cccttcaatt caagtaacag gaaacaagat      120

tttggtgaag cagtcgccca tgcttgtagc gtacgacaat gcggtcaacc ttagctgcaa      180

gtattcctac aatctcttct caagggagtt ccgggcatcc cttcacaaag gactggatag      240

tgctgtggaa gtctgtgttg tatatgggaa ttactcccag cagcttcagg tttactcaaa      300

aacggggttc aactgtgatg ggaaattggg caatgaatca gtgacattct acctccagaa      360

tttgtatgtt aaccaaacag atatttactt ctgcaaaatt gaagttatgt atcctcctcc      420

ttacctagac aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg      480

tccaagtccc ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg      540

agtcctggct tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag      600

taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc      660

cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctcctg      720

acacggacgc ctatccagaa gccagccggc tggcagcccc catctgctca atatcactgc      780

tctggatagg aaatgaccgc catctccagc cggccacctc aggcccctgt tgggccacca      840

atgccaattt ttctcgagtg actagaccaa atatcaagat cattttgaga ctctgaaatg      900

aagtaaaaga gatttcctgt gacaggccaa gtcttacagt gccatggccc acattccaac      960

ttaccatgta cttagtgact tgactgagaa gttagggtag aaaacaaaaa gggagtggat     1020

tctgggagcc tcttcccttt ctcactcacc tgcacatctc agtcaagcaa agtgtggtat     1080

ccacagacat tttagttgca gaagaaaggc taggaaatca ttccttttgg ttaaatgggt     1140

gtttaatctt ttggttagtg ggttaaacgg ggtaagttag agtaggggga gggataggaa     1200

gacatattta aaaaccatta aaacactgtc tcccactcat gaaatgagcc acgtagttcc     1260

tatttaatgc tgttttcctt tagtttagaa atacatagac attgtctttt atgaattctg     1320

atcatattta gtcattttga ccaaatgagg gatttggtca aatgagggat tccctcaaag     1380

caatatcagg taaaccaagt tgctttcctc actccctgtc atgagacttc agtgttaatg     1440

ttcacaatat actttcgaaa gaataaaata gttctcctac atgaagaaag aatatgtcag     1500

gaaataaggt cactttatgt caaaattatt tgagtactat gggacctggc gcagtggctc     1560

atgcttgtaa tcccagcact ttgggaggcc gaggtgggca gatcacttga gatcaggacc     1620

agcctggtca agatggtgaa actccgtctg tactaaaaat acaaaattta gcttggcctg     1680

gtggcaggca cctgtaatcc cagctgccca agaggctgag gcatgagaat cgcttgaacc     1740

tggcaggcgg aggttgcagt gagccgagat agtgccacag ctctccagcc tgggcgacag     1800

agtgagactc catctcaaac aacaacaaca acaacaacaa caacaacaaa ccacaaaatt     1860

atttgagtac tgtgaaggat tatttgtcta acagttcatt ccaatcagac caggtaggag     1920

ctttcctgtt tcatatgttt cagggttgca cagttggtct ctttaatgtc ggtgtggaga     1980

tccaaagtgg gttgtggaaa gagcgtccat aggagaagtg agaatactgt gaaaaaggga     2040

tgttagcatt cattagagta tgaggatgag tcccaagaag gttctttgga aggaggacga     2100

atagaatgga gtaatgaaat tcttgccatg tgctgaggag atagccagca ttaggtgaca     2160

atcttccaga agtggtcagg cagaaggtgc cctggtgaga gctcctttac agggacttta     2220

tgtggtttag ggctcagagc tccaaaactc tgggctcagc tgctcctgta ccttggaggt     2280

ccattcacat gggaaagtat tttggaatgt gtcttttgaa gagagcatca gagttcttaa     2340

gggactgggt aaggcctgac cctgaaatga ccatggatat ttttctacct acagtttgag     2400

tcaactagaa tatgcctggg gaccttgaag aatggccctt cagtggccct caccatttgt     2460

tcatgcttca gttaattcag gtgttgaagg agcttaggtt ttagaggcac gtagacttgg     2520

ttcaagtctc gttagtagtt gaatagcctc aggcaagtca ctgcccacct aagatgatgg     2580

ttcttcaact ataaaatgga gataatggtt acaaatgtct cttcctatag tataatctcc     2640

ataagggcat ggcccaagtc tgtctttgac tctgcctatc cctgacattt agtagcatgc     2700

ccgacataca atgttagcta ttggtattat tgccatatag ataaattatg tataaaaatt     2760

aaactgggca atagcctaag aaggggggaa tattgtaaca caaatttaaa cccactacgc     2820

agggatgagg tgctataata tgaggacctt ttaacttcca tcattttcct gtttcttgaa     2880

atagtttatc ttgtaatgaa atataaggca cctcccactt ttatgtatag aaagaggtct     2940

tttaattttt ttttaatgtg agaaggaagg gaggagtagg aatcttgaga ttccagatcg     3000

aaaatactgt actttggttg atttttaagt gggcttccat tccatggatt taatcagtcc     3060

caagaagatc aaactcagca gtacttgggt gctgaagaac tgttggattt accctggcac     3120

gtgtgccact tgccagcttc ttgggcacac agagttcttc aatccaagtt atcagattgt     3180

atttgaaaat gacagagctg gagagttttt tgaaatggca gtggcaaata aataaatact     3240

tttttttaaa tggaaagact tgatctatgg taataaatga ttttgttttc tgactggaaa     3300

aataggccta ctaaagatga atcacacttg agatgtttct tactcactct gcacagaaac     3360

aaagaagaaa tgttatacag ggaagtccgt tttcactatt agtatgaacc aagaaatggt     3420

tcaaaaacag tggtaggagc aatgctttca tagtttcaga tatggtagtt atgaagaaaa     3480

caatgtcatt tgctgctatt attgtaagag tcttataatt aatggtactc ctataatttt     3540

tgattgtgag ctcacctatt tgggttaagc atgccaattt aaagagacca agtgtatgta     3600

cattatgttc tacatattca gtgataaaat tactaaacta ctatatgtct gctttaaatt     3660

tgtactttaa tattgtcttt tggtattaag aaagatatgc tttcagaata gatatgcttc     3720

gctttggcaa ggaatttgga tagaacttgc tatttaaaag aggtgtgggg taaatccttg     3780

tataaatctc cagtttagcc ttttttgaaa aagctagact ttcaaatact aatttcactt     3840

caagcagggt acgtttctgg tttgtttgct tgacttcagt cacaatttct tatcagacca     3900

atggctgacc tctttgagat gtcaggctag gcttacctat gtgttctgtg tcatgtgaat     3960

gctgagaagt ttgacagaga tccaacttca gccttgaccc catcagtccc tcgggttaac     4020

taactgagcc accggtcctc atggctattt taatgagggt attgatggtt aaatgcatgt     4080

ctgatccctt atcccagcca tttgcactgc cagctgggaa ctataccaga cctggatact     4140

gatcccaaag tgttaaattc aactacatgc tggagattag agatggtgcc aataaaggac     4200

ccagaaccag gatcttgatt gctatagact tattaataat ccaggtcaaa gagagtgaca     4260

cacactctct caagacctgg ggtgagggag tctgtgttat ctgcaaggcc atttgaggct     4320

cagaaagtct ctctttccta tagatatatg catactttct gacatatagg aatgtatcag     4380

gaatactcaa ccatcacagg catgttccta cctcagggcc tttacatgtc ctgtttactc     4440

tgtctagaat gtccttctgt agatgacctg gcttgcctcg tcacccttca ggtccttgct     4500

caagtgtcat cttctcccct agttaaacta ccccacaccc tgtctgcttt ccttgcttat     4560

ttttctccat agcattttac catctcttac attagacatt tttcttattt atttgtagtt     4620

tataagcttc atgaggcaag taactttgct ttgtttcttg ctgtatctcc agtgcccaga     4680

gcagtgcctg gtatataata aatatttatt gactgagtga a                         4721


