                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
       Galmed Research and Development Ltd.
       NAOR, David
       BAHARAFF, Allen
       POSNER, John
 
<120>  PEPTIDES FOR TREATING ACUTE RESPIRATORY DISTRESS SYNDROME

<130>  88945

<150>  US 63/060,718
<151>  2020-08-04

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  1

Met Thr Ala Asp Val 
1               5   


<210>  2
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  2

Met Thr Ala Asp Val Asp Arg 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  3

Thr Arg Met Thr Ala Asp Val Asp Arg 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  AMIDATION

<400>  4

Met Thr Ala Asp Val 
1               5   


<210>  5
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  5

Met Thr Ala Asp Val Asp Arg 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  6

Thr Arg Met Thr Ala Asp Val Asp Arg 
1               5                   


<210>  7
<211>  5748
<212>  DNA
<213>  Homo sapiens

<400>  7
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc actttgatga gcactagtgc tacagcaact gagacagcaa     1140

ccaagaggca agaaacctgg gattggtttt catggttgtt tctaccatca gagtcaaaga     1200

atcatcttca cacaacaaca caaatggctg gtacgtcttc aaataccatc tcagcaggct     1260

gggagccaaa tgaagaaaat gaagatgaaa gagacagaca cctcagtttt tctggatcag     1320

gcattgatga tgatgaagat tttatctcca gcaccatttc aaccacacca cgggcttttg     1380

accacacaaa acagaaccag gactggaccc agtggaaccc aagccattca aatccggaag     1440

tgctacttca gacaaccaca aggatgactg atgtagacag aaatggcacc actgcttatg     1500

aaggaaactg gaacccagaa gcacaccctc ccctcattca ccatgagcat catgaggaag     1560

aagagacccc acattctaca agcacaatcc aggcaactcc tagtagtaca acggaagaaa     1620

cagctaccca gaaggaacag tggtttggca acagatggca tgagggatat cgccaaacac     1680

ccaaagaaga ctcccattcg acaacaggga cagctgcagc ctcagctcat accagccatc     1740

caatgcaagg aaggacaaca ccaagcccag aggacagttc ctggactgat ttcttcaacc     1800

caatctcaca ccccatggga cgaggtcatc aagcaggaag aaggatggat atggactcca     1860

gtcatagtat aacgcttcag cctactgcaa atccaaacac aggtttggtg gaagatttgg     1920

acaggacagg acctctttca atgacaacgc agcagagtaa ttctcagagc ttctctacat     1980

cacatgaagg cttggaagaa gataaagacc atccaacaac ttctactctg acatcaagca     2040

ataggaatga tgtcacaggt ggaagaagag acccaaatca ttctgaaggc tcaactactt     2100

tactggaagg ttatacctct cattacccac acacgaagga aagcaggacc ttcatcccag     2160

tgacctcagc taagactggg tcctttggag ttactgcagt tactgttgga gattccaact     2220

ctaatgtcaa tcgttcctta tcaggagacc aagacacatt ccaccccagt ggggggtccc     2280

ataccactca tggatctgaa tcagatggac actcacatgg gagtcaagaa ggtggagcaa     2340

acacaacctc tggtcctata aggacacccc aaattccaga atggctgatc atcttggcat     2400

ccctcttggc cttggctttg attcttgcag tttgcattgc agtcaacagt cgaagaaggt     2460

gtgggcagaa gaaaaagcta gtgatcaaca gtggcaatgg agctgtggag gacagaaagc     2520

caagtggact caacggagag gccagcaagt ctcaggaaat ggtgcatttg gtgaacaagg     2580

agtcgtcaga aactccagac cagtttatga cagctgatga gacaaggaac ctgcagaatg     2640

tggacatgaa gattggggtg taacacctac accattatct tggaaagaaa caaccgttgg     2700

aaacataacc attacaggga gctgggacac ttaacagatg caatgtgcta ctgattgttt     2760

cattgcgaat cttttttagc ataaaatttt ctactctttt tgttttttgt gttttgttct     2820

ttaaagtcag gtccaatttg taaaaacagc attgctttct gaaattaggg cccaattaat     2880

aatcagcaag aatttgatcg ttccagttcc cacttggagg cctttcatcc ctcgggtgtg     2940

ctatggatgg cttctaacaa aaactacaca tatgtattcc tgatcgccaa cctttccccc     3000

accagctaag gacatttccc agggttaata gggcctggtc cctgggagga aatttgaatg     3060

ggtccatttt gcccttccat agcctaatcc ctgggcattg ctttccactg aggttggggg     3120

ttggggtgta ctagttacac atcttcaaca gaccccctct agaaattttt cagatgcttc     3180

tgggagacac ccaaagggtg aagctattta tctgtagtaa actatttatc tgtgtttttg     3240

aaatattaaa ccctggatca gtcctttgat cagtataatt ttttaaagtt actttgtcag     3300

aggcacaaaa gggtttaaac tgattcataa taaatatctg tacttcttcg atcttcacct     3360

tttgtgctgt gattcttcag tttctaaacc agcactgtct gggtccctac aatgtatcag     3420

gaagagctga gaatggtaag gagactcttc taagtcttca tctcagagac cctgagttcc     3480

cactcagacc cactcagcca aatctcatgg aagaccaagg agggcagcac tgtttttgtt     3540

ttttgttttt tgtttttttt ttttgacact gtccaaaggt tttccatcct gtcctggaat     3600

cagagttgga agctgaggag cttcagcctc ttttatggtt taatggccac ctgttctctc     3660

ctgtgaaagg ctttgcaaag tcacattaag tttgcatgac ctgttatccc tggggcccta     3720

tttcatagag gctggcccta ttagtgattt ccaaaaacaa tatggaagtg ccttttgatg     3780

tcttacaata agagaagaag ccaatggaaa tgaaagagat tggcaaaggg gaaggatgat     3840

gccatgtaga tcctgtttga catttttatg gctgtatttg taaacttaaa cacaccagtg     3900

tctgttcttg atgcagttgc tatttaggat gagttaagtg cctggggagt ccctcaaaag     3960

gttaaaggga ttcccatcat tggaatctta tcaccagata ggcaagttta tgaccaaaca     4020

agagagtact ggctttatcc tctaacctca tattttctcc cacttggcaa gtcctttgtg     4080

gcatttattc atcagtcagg gtgtccgatt ggtcctagaa cttccaaagg ctgcttgtca     4140

tagaagccat tgcatctata aagcaacggc tcctgttaaa tggtatctcc tttctgaggc     4200

tcctactaaa agtcatttgt tacctaaact tatgtgctta acaggcaatg cttctcagac     4260

cacaaagcag aaagaagaag aaaagctcct gactaaatca gggctgggct tagacagagt     4320

tgatctgtag aatatcttta aaggagagat gtcaactttc tgcactattc ccagcctctg     4380

ctcctccctg tctaccctct cccctccctc tctccctcca cttcacccca caatcttgaa     4440

aaacttcctt tctcttctgt gaacatcatt ggccagatcc attttcagtg gtctggattt     4500

ctttttattt tcttttcaac ttgaaagaaa ctggacatta ggccactatg tgttgttact     4560

gccactagtg ttcaagtgcc tcttgttttc ccagagattt cctgggtctg ccagaggccc     4620

agacaggctc actcaagctc tttaactgaa aagcaacaag ccactccagg acaaggttca     4680

aaatggttac aacagcctct acctgtcgcc ccagggagaa aggggtagtg atacaagtct     4740

catagccaga gatggttttc cactccttct agatattccc aaaaagaggc tgagacagga     4800

ggttattttc aattttattt tggaattaaa tacttttttc cctttattac tgttgtagtc     4860

cctcacttgg atatacctct gttttcacga tagaaataag ggaggtctag agcttctatt     4920

ccttggccat tgtcaacgga gagctggcca agtcttcaca aacccttgca acattgcctg     4980

aagtttatgg aataagatgt attctcactc ccttgatctc aagggcgtaa ctctggaagc     5040

acagcttgac tacacgtcat ttttaccaat gattttcagg tgacctgggc taagtcattt     5100

aaactgggtc tttataaaag taaaaggcca acatttaatt attttgcaaa gcaacctaag     5160

agctaaagat gtaatttttc ttgcaattgt aaatcttttg tgtctcctga agacttccct     5220

taaaattagc tctgagtgaa aaatcaaaag agacaaaaga catcttcgaa tccatatttc     5280

aagcctggta gaattggctt ttctagcaga acctttccaa aagttttata ttgagattca     5340

taacaacacc aagaattgat tttgtagcca acattcattc aatactgtta tatcagagga     5400

gtaggagaga ggaaacattt gacttatctg gaaaagcaaa atgtacttaa gaataagaat     5460

aacatggtcc attcaccttt atgttataga tatgtctttg tgtaaatcat ttgttttgag     5520

ttttcaaaga atagcccatt gttcattctt gtgctgtaca atgaccactg ttattgttac     5580

tttgactttt cagagcacac ccttcctctg gtttttgtat atttattgat ggatcaataa     5640

taatgaggaa agcatgatat gtatattgct gagttgaaag cacttattgg aaaatattaa     5700

aaggctaaca ttaaaagact aaaggaaaca gaaaaaaaaa aaaaaaaa                  5748


<210>  8
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  9
<211>  2100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD44vRA nucleotide acid sequence

<400>  9
atggacaagt tttggtggca cgcagcctgg ggactctgcc tcgtgccgct gagcctggcg       60

cagatcgatt tgaatataac ctgccgcttt gcaggtgtat tccacgtgga gaaaaatggt      120

cgctacagca tctctcggac ggaggccgct gacctctgca aggctttcaa tagcaccttg      180

cccacaatgg cccagatgga gaaagctctg agcatcggat ttgagacctg caggtatggg      240

ttcatagaag ggcacgtggt gattccccgg atccacccca actccatctg tgcagcaaac      300

aacacagggg tgtacatcct cacatccaac acctcccagt atgacacata ttgcttcaat      360

gcttcagctc cacctgaaga agattgtaca tcagtcacag acctgcccaa tgcctttgat      420

ggaccaatta ccataactat tgttaaccgt gatggcaccc gctatgtcca gaaaggagaa      480

tacagaacga atcctgaaga catctacccc agcaacccta ctgatgatga cgtgagcagc      540

ggctcctcca gtgaaaggag cagcacttca ggaggttaca tcttttacac cttttctact      600

gtacacccca tcccagacga agacagtccc tggatcaccg acagcacaga cagaatccct      660

gctaccagta cgtcttcaaa taccatctca gcaggctggg agccaaatga agaaaatgaa      720

gatgaaagag acagacacct cagtttttct ggatcaggca ttgatgatga tgaagatttt      780

atctccagca ccatttcaac cacaccacgg gcttttgacc acacaaaaca gaaccaggac      840

tggacccagt ggaacccaag ccattcaaat ccggaagtgc tacttcagac aaccacaagg      900

atgactgcag atgtagacag aaatggcacc actgcttatg aaggaaactg gaacccagaa      960

gcacaccctc ccctcattca ccatgagcat catgaggaag aagagacccc acattctaca     1020

agcacaatcc aggcaactcc tagtagtaca acggaagaaa cagctaccca gaaggaacag     1080

tggtttggca acagatggca tgagggatat cgccaaacac ccagagaaga ctcccattcg     1140

acaacaggga cagctgcagc ctcagctcat accagccatc caatgcaagg aaggacaaca     1200

ccaagcccag aggacagttc ctggactgat ttcttcaacc caatctcaca ccccatggga     1260

cgaggtcatc aagcaggaag aaggatggat atggactcca gtcatagtac aacgcttcag     1320

cctactgcaa atccaaacac aggtttggtg gaagatttgg acaggacagg acctctttca     1380

atgacaacgc agcagagtaa ttctcagagc ttctctacat cacatgaagg cttggaagaa     1440

gataaagacc atccaacaac ttctactctg acatcaagca ataggaatga tgtcacaggt     1500

ggaagaagag acccaaatca ttctgaaggc tcaactactt tactggaagg ttatacctct     1560

cattacccac acacgaagga aagcaggacc ttcatcccag tgacctcagc taagactggg     1620

tcctttggag ttactgcagt tactgttgga gattccaact ctaatgtcaa tcgttcctta     1680

tcaggagacc aagacacatt ccaccccagt ggggggtccc ataccactca tggatctgaa     1740

tcagatggac actcacatgg gagtcaagaa ggtggagcaa acacaacctc tggtcctata     1800

aggacacccc aaattccaga atggctgatc atcttggcat ccctcttggc cttggctttg     1860

attcttgcag tttgcattgc agtcaacagt cgaagaaggt gtgggcagaa gaaaaagcta     1920

gtgatcaaca gtggcaatgg agctgtggag gacagaaagc caagtggact caacggagag     1980

gccagcaagt ctcaggaaat ggtgcatttg gtgaacaagg agtcgtcaga aactccagac     2040

cagtttatga cagctgatga gacaaggaac ctgcagaatg tggacatgaa gattggggtg     2100


<210>  10
<211>  700
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD44vRA amino acid sequence

<400>  10

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Thr 
    210                 215                 220                 


Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 


Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     


Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 
            260                 265                 270         


Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 
        275                 280                 285             


Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Ala Asp 
    290                 295                 300                 


Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu 
305                 310                 315                 320 


Ala His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr 
                325                 330                 335     


Pro His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu 
            340                 345                 350         


Glu Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu 
        355                 360                 365             


Gly Tyr Arg Gln Thr Pro Arg Glu Asp Ser His Ser Thr Thr Gly Thr 
    370                 375                 380                 


Ala Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr 
385                 390                 395                 400 


Pro Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser 
                405                 410                 415     


His Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp 
            420                 425                 430         


Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly 
        435                 440                 445             


Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln 
    450                 455                 460                 


Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu 
465                 470                 475                 480 


Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn 
                485                 490                 495     


Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr 
            500                 505                 510         


Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser 
        515                 520                 525             


Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val 
    530                 535                 540                 


Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu 
545                 550                 555                 560 


Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr 
                565                 570                 575     


His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly 
            580                 585                 590         


Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp 
        595                 600                 605             


Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val 
    610                 615                 620                 


Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu 
625                 630                 635                 640 


Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly 
                645                 650                 655     


Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn 
            660                 665                 670         


Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr 
        675                 680                 685             


Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 700 


<210>  11
<211>  518
<212>  DNA
<213>  Homo sapiens

<400>  11
agggacccgc agctcagcta cagcacagat cagcaccatg aagcttctca cgggcctggt       60

tttctgctcc ttggtcctgg gtgtcagcag ccgaagcttc ttttcgttcc ttggcgaggc      120

ttttgatggg gctcgggaca tgtggagagc ctactctgac atgagagaag ccaattacat      180

cggctcagac aaatacttcc atgctcgggg gaactatgat gctgccaaaa ggggacctgg      240

gggtgcctgg gctgcagaag tgatcaccga tgccagagag aatatccaga gattctttgg      300

ccatggtgcg gaggactcgc tggctgatca ggctgccaat gaatggggca ggagtggcaa      360

agaccccaat cacttccgac ctgctggcct gcctgagaaa tactgagctt cctcttcact      420

ctgctctcag gagatctggc tgtgaggccc tcagggcagg gatacaaagc ggggagaggg      480

tacacaatgg gtatctaata aatacttaag aggtggaa                              518


<210>  12
<211>  726
<212>  DNA
<213>  Homo sapiens

<400>  12
aggctcagta taaatagcag ccaccgctcc ctggcaggca gggacccgca gctcagctac       60

agcacagatc aggtgaggag cacaccaagg agtgattttt aaaacttact ctgttttctc      120

tttcccaaca agattatcat ttcctttaaa aaaaatagtt atcctggggc atacagccat      180

accattctga aggtgtctta tctcctctga tctagagagc accatgaagc ttctcacggg      240

cctggttttc tgctccttgg tcctgggtgt cagcagccga agcttctttt cgttccttgg      300

cgaggctttt gatggggctc gggacatgtg gagagcctac tctgacatga gagaagccaa      360

ttacatcggc tcagacaaat acttccatgc tcgggggaac tatgatgctg ccaaaagggg      420

acctgggggt gcctgggctg cagaagtgat cagcgatgcc agagagaata tccagagatt      480

ctttggccat ggtgcggagg actcgctggc tgatcaggct gccaatgaat ggggcaggag      540

tggcaaagac cccaatcact tccgacctgc tggcctgcct gagaaatact gagcttcctc      600

ttcactctgc tctcaggaga tctggctgtg aggccctcag ggcagggata caaagcgggg      660

agagggtaca caatgggtat ctaataaata cttaagaggt ggaatttgtg gaaaaaaaaa      720

aaaaaa                                                                 726


<210>  13
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  14
<211>  609
<212>  DNA
<213>  Mus musculus

<400>  14
atagatcacc agatctgccc aggagacacc aggatgaagc tactcaccag cctggtcttc       60

tgctccctgc tcctgggagt ctgccatgga gggttttttt catttgttca cgaggctttc      120

caaggggctg gggacatgtg gcgagcctac actgacatga aggaagctaa ctggaaaaac      180

tcagacaaat acttccatgc tcgggggaac tatgatgctg ctcaaagggg tcccggggga      240

gtctgggctg ctgagaaaat cagtgatgga agagaggcct ttcaggaatt cttcggcaga      300

ggacatgagg acaccattgc tgaccaggaa gccaacagac atggccgcag tggcaaagac      360

cccaattact acagacctcc tggactgcct gacaaatact gagcgtcctc ctattagctc      420

agtaggttgt gctgggggcc tgagggtggg gtctgggctt cttcctacct aggaacactg      480

aagatgctct ctggggaaac attgtatatc tctcatgtgt gtatcccaca agggtttcag      540

aactgagtta ctcttgcagt agtaactgct tgaggaggag agggtaataa acagaaactt      600

ggaagtgga                                                              609


<210>  15
<211>  2034
<212>  DNA
<213>  Homo sapiens

<400>  15
actataaata gcagccacct ctccctggca gacagggacc cgcagctcag ctacagcaca       60

gatcagcacc atgaagcttc tcacgggcct ggttttctgc tccttggtcc tgagtgtcag      120

cagccgaagc ttcttttcgt tccttggcga ggcttttgat ggggctcggg acatgtggag      180

agcctactct gacatgagag aagccaatta catcggctca gacaaatact tccatgctcg      240

ggggaactat gatgctgcca aaaggggacc tgggggtgcc tgggctgcag aagtgatcag      300

tttattttca gctgaactgt agagagtgaa ggaagaagcc ttttttcttc actcctacat      360

gacccaggca ttgatccagg caatgaagat tcagtgtaaa taaccaccac taacaagacc      420

atggcctttg gaacctgtgc taagaggcat ggatgagctc cctcagcatg tggatggaga      480

ctgaagagag gtctgaaggc tcagtgtggt gtctccattc tctaagaagt ttggaggaga      540

agctggatac agcaaaacag actgagaagg agcagctgtt gggaaaggag gaaaactagg      600

aaagcatggt gttccagaat ccctgatgga gatattgatt agtagtatca gattctgctt      660

agcagttgag gagttcacct ttggcttaag caacatggag tcattgacta tctcgtgaag      720

gtggttgcag gagaaggtct ggagaactaa atggagcagt gataagagag aatgggagat      780

ggtatgatag gactcctgga caccccagac atcaatcaaa acaccacaga caagaaggtg      840

tggatacaaa aactagcagt tagaagaaat aatagaaaat gaactccaac tacttctgaa      900

aaaaaagtaa tgagggcaat taatacattg aagaaagcct caataagtac aacagtgtag      960

tactgactta tatatagaaa aaacctgatc agtggaacca aatcctcaga attagacata     1020

agtgcatatg agaattttgt atgtgataaa ggttgtatgt taacgtatta agtaaaagac     1080

ggactattca acaaatggga ttggtacaac tgggtgacca tctaaaataa catcatgttg     1140

aaaacatact gtatatatta cggtaggaca aattccaaat atgctaaata tttataaaca     1200

aataaggaaa atgataataa taatattaac attatctggt gaatccatgg aaaattcttt     1260

tatagcccaa agtagggaaa gctgcaacaa caaggatgga actggaggtc attatgctaa     1320

gtgaaatcat tcaggaacag aaagacaaac atcacatgtt ctcacttatt tgtgggatct     1380

aaaaatcaaa acaattgaat tcatggagat agagaataga aggatggtta ccagaggctg     1440

ggaagggtag tggggagggg gggagtgagg ggaggtgagg atggttaatg agtaccaaaa     1500

aaatacttag aatgaataag agctagtatt tgatagcaca acgggggact atagtcagta     1560

ataatttagc tgtacattgt aaaataacca aaagagtata attggattat ttgtaacaca     1620

aaggataaat gcttgagggg atggataccc aattttccat gatgtgatta ttgcgcattg     1680

catggctgta ccaaaatatc tcatgtaccc cataattata tacacctact atgtacccac     1740

aaaaaatttt taaaaaggaa tgaaataaaa acatttgagt ttaagaaaac cacaaaaaaa     1800

caaagtaggg aaagctcttc aaatactatg aaattgagaa gacaactaaa gaaaatatta     1860

ataaagacaa gaacataaat aatttctttg gcagaacata agccatcata atcagaagat     1920

aaataagctg ggaaaaatat ttgtaactca tatcctagat aacatactca ttttccctgt     1980

atataaaaag tttctctaat gtgataaata aaaacacaat aaaccagtaa aaaa           2034


<210>  16
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  16
actataaata gcagccacct ctccctggca gacagggacc cgcagctcag ctacagcaca       60

gatcagcacc atgaagcttc tcacgggcct ggttttctgc tccttggtcc tgagtgtcag      120

cagccgaagc ttcttttcgt tccttggcga ggcttttgat ggggctcggg acatgtggag      180

agcctactct gacatgagag aagccaatta catcggctca gacaaatact tccatgctcg      240

ggggaactat gatgctgcca aaaggggacc tgggggtgcc tgggctgcag aagtgatcag      300

caatgccaga gagaatatcc agagactcac aggccgtggt gcggaggact cgctggccga      360

tcaggctgcc aataaatggg gcaggagtgg cagagacccc aatcacttcc gacctgctgg      420

cctgcctgag aaatactgag cttcctcttc actctgctct caggagacct ggctatgagg      480

ccctcggggc agggatacaa agttagtgag gtctatgtcc agagaagctg agatatggca      540

tataataggc atctaataaa tgcttaagag gtggaa                                576


<210>  17
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  18
<211>  609
<212>  DNA
<213>  Mus musculus

<400>  18
atagaccacc agatctgccc aggagacacc agcaggatga agctactcac cagcctggtc       60

ttctgctccc tgctcctggg agtctgccat ggagggtttt tttcatttat tggggaggct      120

ttccaagggg ctggagacat gtggcgagcc tacactgaca tgaaggaagc tggctggaaa      180

gatggagaca aatacttcca tgctcggggg aactatgatg ctgcccaaag gggtcccggg      240

ggagtctggg ctgctgagaa aatcagtgat gcaagagaga gctttcagga attcttcggc      300

agaggacacg aggacaccat ggctgaccag gaagccaaca gacatggccg cagtggcaaa      360

gaccccaatt actacagacc tcctggactg cctgccaaat actgagagtc ctcctattag      420

ttcagaaggc tgtgttgggg tcctgagggt ggggtctggg cttcctatct aggaacactg      480

aagatgctct ctggggcaac atagtatacc tctcatgtgt gtatcccaca agggtttcag      540

aatggagtta ctcgagcagt agtaactgct tgaggaggag agggtaataa acaggaactt      600

ggaagtgga                                                              609


<210>  19
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  19
agcagaggta ccaactatag ctccacggcc agaagatacc agcagctctg cctttactga       60

aatttcatct ggagaaaggt ccacagcaca atgaggcttt tcacaggcat tgttttctgc      120

tccttggtca tgggagtcac cagtgaaagc tggcgttcgt ttttcaagga ggctctccaa      180

ggggttgggg acatgggcag agcctattgg gacataatga tatccaatca ccaaaattca      240

aacagatatc tctatgctcg gggaaactat gatgctgccc aaagaggacc tgggggtgtc      300

tgggctgcta aactcatcag ccgttccagg gtctatcttc agggattaat agactgctat      360

ttatttggaa acagcagcac tgtattggag gactcgaagt ccaacgagaa agctgaggaa      420

tggggccgga gtggcaaaga ccccgaccgc ttcagacctg acggcctgcc taagaaatac      480

tgagcttcct gctcctctgc tctcagggaa actgggctgt gagccacaca cttctccccc      540

cagacaggga cacagggtca ctgagctttg tgtccccagg aactggtata gggcacctag      600

aggtgttcaa taaatgtttg tcaaattgaa                                       630


<210>  20
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Cys Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


