                         SEQUENCE LISTING

<110>  EUKARYS
 
<120>  ARTIFICIAL EUKARYOTIC EXPRESSION SYSTEM WITH ENHANCED 
       PERFORMANCES

<130>  B14313WO CS/PPT

<150>  EP20305899.5
<151>  2020-08-04

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  5259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant DNA: open-reading frame from pC3P3-G1 plasmid

<400>  1
atggccagcc tggacaacct ggtggccaga taccagcggt gcttcaacga ccagagcctg       60

aagaacagca ccatcgagct ggaaatccgg ttccagcaga tcaacttcct gctgttcaag      120

accgtgtacg aggccctggt cgcccaggaa atccccagca ccatcagcca cagcatccgg      180

tgcatcaaga aggtgcacca cgagaaccac tgccgggaga agatcctgcc cagcgagaac      240

ctgtacttca agaaacagcc cctgatgttc ttcaagttca gcgagcccgc cagcctgggc      300

tgtaaagtgt ccctggccat cgagcagccc atccggaagt tcatcctgga cagcagcgtg      360

ctggtccggc tgaagaaccg gaccaccttc cgggtgtccg agctgtggaa gatcgagctg      420

accatcgtga agcagctgat gggcagcgag gtgtcagcca agctggccgc cttcaagacc      480

ctgctgttcg acacccccga gcagcagacc accaagaaca tgatgaccct gatcaacccc      540

gacgacgagt acctgtacga gatcgagatc gagtacaccg gcaagcctga gagcctgaca      600

gccgccgacg tgatcaagat caagaacacc gtgctgacac tgatcagccc caaccacctg      660

atgctgaccg cctaccacca ggccatcgag tttatcgcca gccacatcct gagcagcgag      720

atcctgctgg cccggatcaa gagcggcaag tggggcctga agagactgct gccccaggtc      780

aagtccatga ccaaggccga ctacatgaag ttctaccccc ccgtgggcta ctacgtgacc      840

gacaaggccg acggcatccg gggcattgcc gtgatccagg acacccagat ctacgtggtg      900

gccgaccagc tgtacagcct gggcaccacc ggcatcgagc ccctgaagcc caccatcctg      960

gacggcgagt tcatgcccga gaagaaagag ttctacggct ttgacgtgat catgtacgag     1020

ggcaacctgc tgacccagca gggcttcgag acacggatcg agagcctgag caagggcatc     1080

aaggtgctgc aggccttcaa catcaaggcc gagatgaagc ccttcatcag cctgacctcc     1140

gccgacccca acgtgctgct gaagaatttc gagagcatct tcaagaagaa aacccggccc     1200

tacagcatcg acggcatcat cctggtggag cccggcaaca gctacctgaa caccaacacc     1260

ttcaagtgga agcccacctg ggacaacacc ctggactttc tggtccggaa gtgccccgag     1320

tccctgaacg tgcccgagta cgcccccaag aagggcttca gcctgcatct gctgttcgtg     1380

ggcatcagcg gcgagctgtt taagaagctg gccctgaact ggtgccccgg ctacaccaag     1440

ctgttccccg tgacccagcg gaaccagaac tacttccccg tgcagttcca gcccagcgac     1500

ttccccctgg ccttcctgta ctaccacccc gacaccagca gcttcagcaa catcgatggc     1560

aaggtgctgg aaatgcggtg cctgaagcgg gagatcaact acgtgcgctg ggagatcgtg     1620

aagatccggg aggaccggca gcaggatctg aaaaccggcg gctacttcgg caacgacttc     1680

aagaccgccg agctgacctg gctgaactac atggacccct tcagcttcga ggaactggcc     1740

aagggaccca gcggcatgta cttcgctggc gccaagaccg gcatctacag agcccagacc     1800

gccctgatca gcttcatcaa gcaggaaatc atccagaaga tcagccacca gagctgggtg     1860

atcgacctgg gcatcggcaa gggccaggac ctgggcagat acctggacgc cggcgtgaga     1920

cacctggtcg gcatcgataa ggaccagaca gccctggccg agctggtgta ccggaagttc     1980

tcccacgcca ccaccagaca gcacaagcac gccaccaaca tctacgtgct gcaccaggat     2040

ctggccgagc ctgccaaaga aatcagcgag aaagtgcacc agatctatgg cttccccaaa     2100

gagggcgcca gcagcatcgt gtccaacctg ttcatccact acctgatgaa gaacacccag     2160

caggtcgaga acctggctgt gctgtgccac aagctgctgc agcctggcgg catggtctgg     2220

ttcaccacca tgctgggcga acaggtgctg gaactgctgc acgagaaccg gatcgaactg     2280

aacgaagtgt gggaggcccg ggagaacgag gtggtcaagt tcgccatcaa gcggctgttc     2340

aaagaggaca tcctgcagga aaccggccag gaaatcggcg tcctgctgcc cttcagcaac     2400

ggcgacttct acaatgagta cctggtcaac accgcctttc tgatcaagat tttcaagcac     2460

catggcttta gcctcgtgca gaagcagagc ttcaaggact ggatccccga gttccagaac     2520

ttcagcaaga gcctgtacaa gatcctgacc gaggccgaca agacctggac cagcctgttc     2580

ggcttcatct gcctgcggaa gaacggaggc gggggaagtg gagggggcgg cagtcaggac     2640

ctgcacgcca tccagctgca gctcgaagag gaaatgttca acggcggcat cagaagattc     2700

gaggccgacc agcagagaca gatcgcctct ggcaacgaga gcgacaccgc ctggaataga     2760

aggctgctgt ctgagctgat cgcccctatg gccgaaggca tccaggccta caaagaggaa     2820

tacgagggca agagaggcag agcccctaga gccctggcct tcatcaactg tgtgggcaat     2880

gaggtggccg cctacatcac catgaagatc gtgatggaca tgctgaacac cgacgtgacc     2940

ctgcaggcca ttgccatgaa cgtggccgac agaatcgagg accaggtccg attcagcaag     3000

ctggaaggac acgccgccaa gtacttcgag aaagtgaaga agtccctgaa ggccagcaag     3060

accaagagct acagacacgc ccacaacgtg gccgtggtgg ccgaaaaatc tgtggccgat     3120

agggacgccg acttctctag atgggaggcc tggcctaagg acaccctgct gcagatcggc     3180

atgaccctgc tggaaatcct ggaaaacagc gtgttcttca acggccagcc cgtgttcctg     3240

agaaccctga ggacaaatgg cggcaagcac ggcgtgtact acctgcagac atctgagcac     3300

gtgggcgagt ggatcaccgc cttcaaagaa catgtggccc agctgagccc tgcctatgcc     3360

ccttgtgtga tccctcctag accctgggtg tcccctttca atggcggctt tcacaccgag     3420

aaggtggcca gcagaatcag actggtcaag ggcaaccggg aacacgtgcg gaagctgacc     3480

aagaaacaga tgcccgccgt gtacaaggcc gtgaatgctc tgcaggccac caagtggcag     3540

gtcaacaaag aggtgctgca ggtcgtcgag gacgtgatca gactggatct gggctacggc     3600

gtgccaagct ttaagcccct gatcgacaga gagaacaagc ccgccaaccc tgtgcccctg     3660

gaatttcagc acctgagagg ccgcgagctg aaagagatgc tgacacctga acagtggcag     3720

gcctttatca attggaaggg cgagtgcacc aagctgtaca ccgccgagac aaagaggggc     3780

tctaagtctg ccgccacagt gcgaatggtc ggacaggcca gaaagtacag ccagttcgac     3840

gccatctact tcgtgtacgc cctggacagc cggtctagag tgtatgccca gagcagcaca     3900

ctgagccccc agtctaacga tctgggaaag gccctgctga gattcaccga gggccagaga     3960

ctggattctg ccgaagccct gaagtggttc ctggtcaacg gcgccaacaa ctggggctgg     4020

gacaagaaaa ccttcgatgt gcggaccgcc aacgtgctgg atagcgagtt ccaggacatg     4080

tgcagagata tcgccgccga ccctctgacc tttacccagt gggtcaacgc cgatagcccc     4140

tatggattcc tggcctggtg cttcgagtac gccagatacc tggacgccct ggatgaggga     4200

acccaggatc agttcatgac ccatctgccc gtgcaccagg atggctcttg ttctggcatc     4260

cagcactaca gcgccatgct gagcgatgcc gtgggagcca aagccgtgaa cctgaagcct     4320

agcgacagcc cccaggatat ctatggcgct gtggcccagg tggtcatcca gaaaaactac     4380

gcctacatga acgccgagga cgccgagaca ttcacaagcg gaagcgtgac actgacaggc     4440

gccgagctga gatctatggc ctctgcctgg gacatgatcg gcatcacacg gggcctgacc     4500

aaaaagcctg tgatgacact gccctacggc agcaccagac tgacctgtag agaaagcgtg     4560

atcgactaca tcgtggacct ggaagagaaa gaggcccaga gagccattgc cgagggcaga     4620

acagccaatc ctgtgcaccc cttcgacaac gaccggaagg atagcctgac acctagcgcc     4680

gcctacaact acatgaccgc cctgatctgg cccagcatct ctgaagtggt caaggcccct     4740

atcgtggcca tgaagatgat cagacagctg gccagattcg ccgccaagag aaatgagggc     4800

ctggaatacc ctctgcccac cggctttatc ctgcagcaga aaatcatggc caccgacatg     4860

ctgcgggtgt ccacatgtct gatgggcgag atcaagatga gcctgcagat cgagacagac     4920

gtggtggacg agacagccat gatgggagcc gccgctccta attttgtgca cggacacgat     4980

gccagccacc tgatcctgac cgtgtgcgat ctggtggaca agggcatcac tagcgtggcc     5040

gtgatccacg atagctttgg aacacacgcc ggcagaaccg ccgacctgag agattctctg     5100

cgggaagaga tggtcaagat gtaccagaac cacaacgccc tgcagaacct gctggacgtg     5160

cacgaagaaa gatggctggt ggacaccggc atccaggtgc cagaacaggg agagttcgac     5220

ctgaacgaga tcctggtgtc cgactactgc ttcgcctga                            5259


<210>  2
<211>  1751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant protein encoded by pC3P3-G1 plasmid

<400>  2

Ala Ser Leu Asp Asn Leu Val Ala Arg Tyr Gln Arg Cys Phe Asn Asp 
1               5                   10                  15      


Gln Ser Leu Lys Asn Ser Thr Ile Glu Leu Glu Ile Arg Phe Gln Gln 
            20                  25                  30          


Ile Asn Phe Leu Leu Phe Lys Thr Val Tyr Glu Ala Leu Val Ala Gln 
        35                  40                  45              


Glu Ile Pro Ser Thr Ile Ser His Ser Ile Arg Cys Ile Lys Lys Val 
    50                  55                  60                  


His His Glu Asn His Cys Arg Glu Lys Ile Leu Pro Ser Glu Asn Leu 
65                  70                  75                  80  


Tyr Phe Lys Lys Gln Pro Leu Met Phe Phe Lys Phe Ser Glu Pro Ala 
                85                  90                  95      


Ser Leu Gly Cys Lys Val Ser Leu Ala Ile Glu Gln Pro Ile Arg Lys 
            100                 105                 110         


Phe Ile Leu Asp Ser Ser Val Leu Val Arg Leu Lys Asn Arg Thr Thr 
        115                 120                 125             


Phe Arg Val Ser Glu Leu Trp Lys Ile Glu Leu Thr Ile Val Lys Gln 
    130                 135                 140                 


Leu Met Gly Ser Glu Val Ser Ala Lys Leu Ala Ala Phe Lys Thr Leu 
145                 150                 155                 160 


Leu Phe Asp Thr Pro Glu Gln Gln Thr Thr Lys Asn Met Met Thr Leu 
                165                 170                 175     


Ile Asn Pro Asp Asp Glu Tyr Leu Tyr Glu Ile Glu Ile Glu Tyr Thr 
            180                 185                 190         


Gly Lys Pro Glu Ser Leu Thr Ala Ala Asp Val Ile Lys Ile Lys Asn 
        195                 200                 205             


Thr Val Leu Thr Leu Ile Ser Pro Asn His Leu Met Leu Thr Ala Tyr 
    210                 215                 220                 


His Gln Ala Ile Glu Phe Ile Ala Ser His Ile Leu Ser Ser Glu Ile 
225                 230                 235                 240 


Leu Leu Ala Arg Ile Lys Ser Gly Lys Trp Gly Leu Lys Arg Leu Leu 
                245                 250                 255     


Pro Gln Val Lys Ser Met Thr Lys Ala Asp Tyr Met Lys Phe Tyr Pro 
            260                 265                 270         


Pro Val Gly Tyr Tyr Val Thr Asp Lys Ala Asp Gly Ile Arg Gly Ile 
        275                 280                 285             


Ala Val Ile Gln Asp Thr Gln Ile Tyr Val Val Ala Asp Gln Leu Tyr 
    290                 295                 300                 


Ser Leu Gly Thr Thr Gly Ile Glu Pro Leu Lys Pro Thr Ile Leu Asp 
305                 310                 315                 320 


Gly Glu Phe Met Pro Glu Lys Lys Glu Phe Tyr Gly Phe Asp Val Ile 
                325                 330                 335     


Met Tyr Glu Gly Asn Leu Leu Thr Gln Gln Gly Phe Glu Thr Arg Ile 
            340                 345                 350         


Glu Ser Leu Ser Lys Gly Ile Lys Val Leu Gln Ala Phe Asn Ile Lys 
        355                 360                 365             


Ala Glu Met Lys Pro Phe Ile Ser Leu Thr Ser Ala Asp Pro Asn Val 
    370                 375                 380                 


Leu Leu Lys Asn Phe Glu Ser Ile Phe Lys Lys Lys Thr Arg Pro Tyr 
385                 390                 395                 400 


Ser Ile Asp Gly Ile Ile Leu Val Glu Pro Gly Asn Ser Tyr Leu Asn 
                405                 410                 415     


Thr Asn Thr Phe Lys Trp Lys Pro Thr Trp Asp Asn Thr Leu Asp Phe 
            420                 425                 430         


Leu Val Arg Lys Cys Pro Glu Ser Leu Asn Val Pro Glu Tyr Ala Pro 
        435                 440                 445             


Lys Lys Gly Phe Ser Leu His Leu Leu Phe Val Gly Ile Ser Gly Glu 
    450                 455                 460                 


Leu Phe Lys Lys Leu Ala Leu Asn Trp Cys Pro Gly Tyr Thr Lys Leu 
465                 470                 475                 480 


Phe Pro Val Thr Gln Arg Asn Gln Asn Tyr Phe Pro Val Gln Phe Gln 
                485                 490                 495     


Pro Ser Asp Phe Pro Leu Ala Phe Leu Tyr Tyr His Pro Asp Thr Ser 
            500                 505                 510         


Ser Phe Ser Asn Ile Asp Gly Lys Val Leu Glu Met Arg Cys Leu Lys 
        515                 520                 525             


Arg Glu Ile Asn Tyr Val Arg Trp Glu Ile Val Lys Ile Arg Glu Asp 
    530                 535                 540                 


Arg Gln Gln Asp Leu Lys Thr Gly Gly Tyr Phe Gly Asn Asp Phe Lys 
545                 550                 555                 560 


Thr Ala Glu Leu Thr Trp Leu Asn Tyr Met Asp Pro Phe Ser Phe Glu 
                565                 570                 575     


Glu Leu Ala Lys Gly Pro Ser Gly Met Tyr Phe Ala Gly Ala Lys Thr 
            580                 585                 590         


Gly Ile Tyr Arg Ala Gln Thr Ala Leu Ile Ser Phe Ile Lys Gln Glu 
        595                 600                 605             


Ile Ile Gln Lys Ile Ser His Gln Ser Trp Val Ile Asp Leu Gly Ile 
    610                 615                 620                 


Gly Lys Gly Gln Asp Leu Gly Arg Tyr Leu Asp Ala Gly Val Arg His 
625                 630                 635                 640 


Leu Val Gly Ile Asp Lys Asp Gln Thr Ala Leu Ala Glu Leu Val Tyr 
                645                 650                 655     


Arg Lys Phe Ser His Ala Thr Thr Arg Gln His Lys His Ala Thr Asn 
            660                 665                 670         


Ile Tyr Val Leu His Gln Asp Leu Ala Glu Pro Ala Lys Glu Ile Ser 
        675                 680                 685             


Glu Lys Val His Gln Ile Tyr Gly Phe Pro Lys Glu Gly Ala Ser Ser 
    690                 695                 700                 


Ile Val Ser Asn Leu Phe Ile His Tyr Leu Met Lys Asn Thr Gln Gln 
705                 710                 715                 720 


Val Glu Asn Leu Ala Val Leu Cys His Lys Leu Leu Gln Pro Gly Gly 
                725                 730                 735     


Met Val Trp Phe Thr Thr Met Leu Gly Glu Gln Val Leu Glu Leu Leu 
            740                 745                 750         


His Glu Asn Arg Ile Glu Leu Asn Glu Val Trp Glu Ala Arg Glu Asn 
        755                 760                 765             


Glu Val Val Lys Phe Ala Ile Lys Arg Leu Phe Lys Glu Asp Ile Leu 
    770                 775                 780                 


Gln Glu Thr Gly Gln Glu Ile Gly Val Leu Leu Pro Phe Ser Asn Gly 
785                 790                 795                 800 


Asp Phe Tyr Asn Glu Tyr Leu Val Asn Thr Ala Phe Leu Ile Lys Ile 
                805                 810                 815     


Phe Lys His His Gly Phe Ser Leu Val Gln Lys Gln Ser Phe Lys Asp 
            820                 825                 830         


Trp Ile Pro Glu Phe Gln Asn Phe Ser Lys Ser Leu Tyr Lys Ile Leu 
        835                 840                 845             


Thr Glu Ala Asp Lys Thr Trp Thr Ser Leu Phe Gly Phe Ile Cys Leu 
    850                 855                 860                 


Arg Lys Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Leu 
865                 870                 875                 880 


His Ala Ile Gln Leu Gln Leu Glu Glu Glu Met Phe Asn Gly Gly Ile 
                885                 890                 895     


Arg Arg Phe Glu Ala Asp Gln Gln Arg Gln Ile Ala Ser Gly Asn Glu 
            900                 905                 910         


Ser Asp Thr Ala Trp Asn Arg Arg Leu Leu Ser Glu Leu Ile Ala Pro 
        915                 920                 925             


Met Ala Glu Gly Ile Gln Ala Tyr Lys Glu Glu Tyr Glu Gly Lys Arg 
    930                 935                 940                 


Gly Arg Ala Pro Arg Ala Leu Ala Phe Ile Asn Cys Val Gly Asn Glu 
945                 950                 955                 960 


Val Ala Ala Tyr Ile Thr Met Lys Ile Val Met Asp Met Leu Asn Thr 
                965                 970                 975     


Asp Val Thr Leu Gln Ala Ile Ala Met Asn Val Ala Asp Arg Ile Glu 
            980                 985                 990         


Asp Gln Val Arg Phe Ser Lys Leu  Glu Gly His Ala Ala  Lys Tyr Phe 
        995                 1000                 1005             


Glu Lys  Val Lys Lys Ser Leu  Lys Ala Ser Lys Thr  Lys Ser Tyr 
    1010                 1015                 1020             


Arg His  Ala His Asn Val Ala  Val Val Ala Glu Lys  Ser Val Ala 
    1025                 1030                 1035             


Asp Arg  Asp Ala Asp Phe Ser  Arg Trp Glu Ala Trp  Pro Lys Asp 
    1040                 1045                 1050             


Thr Leu  Leu Gln Ile Gly Met  Thr Leu Leu Glu Ile  Leu Glu Asn 
    1055                 1060                 1065             


Ser Val  Phe Phe Asn Gly Gln  Pro Val Phe Leu Arg  Thr Leu Arg 
    1070                 1075                 1080             


Thr Asn  Gly Gly Lys His Gly  Val Tyr Tyr Leu Gln  Thr Ser Glu 
    1085                 1090                 1095             


His Val  Gly Glu Trp Ile Thr  Ala Phe Lys Glu His  Val Ala Gln 
    1100                 1105                 1110             


Leu Ser  Pro Ala Tyr Ala Pro  Cys Val Ile Pro Pro  Arg Pro Trp 
    1115                 1120                 1125             


Val Ser  Pro Phe Asn Gly Gly  Phe His Thr Glu Lys  Val Ala Ser 
    1130                 1135                 1140             


Arg Ile  Arg Leu Val Lys Gly  Asn Arg Glu His Val  Arg Lys Leu 
    1145                 1150                 1155             


Thr Lys  Lys Gln Met Pro Ala  Val Tyr Lys Ala Val  Asn Ala Leu 
    1160                 1165                 1170             


Gln Ala  Thr Lys Trp Gln Val  Asn Lys Glu Val Leu  Gln Val Val 
    1175                 1180                 1185             


Glu Asp  Val Ile Arg Leu Asp  Leu Gly Tyr Gly Val  Pro Ser Phe 
    1190                 1195                 1200             


Lys Pro  Leu Ile Asp Arg Glu  Asn Lys Pro Ala Asn  Pro Val Pro 
    1205                 1210                 1215             


Leu Glu  Phe Gln His Leu Arg  Gly Arg Glu Leu Lys  Glu Met Leu 
    1220                 1225                 1230             


Thr Pro  Glu Gln Trp Gln Ala  Phe Ile Asn Trp Lys  Gly Glu Cys 
    1235                 1240                 1245             


Thr Lys  Leu Tyr Thr Ala Glu  Thr Lys Arg Gly Ser  Lys Ser Ala 
    1250                 1255                 1260             


Ala Thr  Val Arg Met Val Gly  Gln Ala Arg Lys Tyr  Ser Gln Phe 
    1265                 1270                 1275             


Asp Ala  Ile Tyr Phe Val Tyr  Ala Leu Asp Ser Arg  Ser Arg Val 
    1280                 1285                 1290             


Tyr Ala  Gln Ser Ser Thr Leu  Ser Pro Gln Ser Asn  Asp Leu Gly 
    1295                 1300                 1305             


Lys Ala  Leu Leu Arg Phe Thr  Glu Gly Gln Arg Leu  Asp Ser Ala 
    1310                 1315                 1320             


Glu Ala  Leu Lys Trp Phe Leu  Val Asn Gly Ala Asn  Asn Trp Gly 
    1325                 1330                 1335             


Trp Asp  Lys Lys Thr Phe Asp  Val Arg Thr Ala Asn  Val Leu Asp 
    1340                 1345                 1350             


Ser Glu  Phe Gln Asp Met Cys  Arg Asp Ile Ala Ala  Asp Pro Leu 
    1355                 1360                 1365             


Thr Phe  Thr Gln Trp Val Asn  Ala Asp Ser Pro Tyr  Gly Phe Leu 
    1370                 1375                 1380             


Ala Trp  Cys Phe Glu Tyr Ala  Arg Tyr Leu Asp Ala  Leu Asp Glu 
    1385                 1390                 1395             


Gly Thr  Gln Asp Gln Phe Met  Thr His Leu Pro Val  His Gln Asp 
    1400                 1405                 1410             


Gly Ser  Cys Ser Gly Ile Gln  His Tyr Ser Ala Met  Leu Ser Asp 
    1415                 1420                 1425             


Ala Val  Gly Ala Lys Ala Val  Asn Leu Lys Pro Ser  Asp Ser Pro 
    1430                 1435                 1440             


Gln Asp  Ile Tyr Gly Ala Val  Ala Gln Val Val Ile  Gln Lys Asn 
    1445                 1450                 1455             


Tyr Ala  Tyr Met Asn Ala Glu  Asp Ala Glu Thr Phe  Thr Ser Gly 
    1460                 1465                 1470             


Ser Val  Thr Leu Thr Gly Ala  Glu Leu Arg Ser Met  Ala Ser Ala 
    1475                 1480                 1485             


Trp Asp  Met Ile Gly Ile Thr  Arg Gly Leu Thr Lys  Lys Pro Val 
    1490                 1495                 1500             


Met Thr  Leu Pro Tyr Gly Ser  Thr Arg Leu Thr Cys  Arg Glu Ser 
    1505                 1510                 1515             


Val Ile  Asp Tyr Ile Val Asp  Leu Glu Glu Lys Glu  Ala Gln Arg 
    1520                 1525                 1530             


Ala Ile  Ala Glu Gly Arg Thr  Ala Asn Pro Val His  Pro Phe Asp 
    1535                 1540                 1545             


Asn Asp  Arg Lys Asp Ser Leu  Thr Pro Ser Ala Ala  Tyr Asn Tyr 
    1550                 1555                 1560             


Met Thr  Ala Leu Ile Trp Pro  Ser Ile Ser Glu Val  Val Lys Ala 
    1565                 1570                 1575             


Pro Ile  Val Ala Met Lys Met  Ile Arg Gln Leu Ala  Arg Phe Ala 
    1580                 1585                 1590             


Ala Lys  Arg Asn Glu Gly Leu  Glu Tyr Pro Leu Pro  Thr Gly Phe 
    1595                 1600                 1605             


Ile Leu  Gln Gln Lys Ile Met  Ala Thr Asp Met Leu  Arg Val Ser 
    1610                 1615                 1620             


Thr Cys  Leu Met Gly Glu Ile  Lys Met Ser Leu Gln  Ile Glu Thr 
    1625                 1630                 1635             


Asp Val  Val Asp Glu Thr Ala  Met Met Gly Ala Ala  Ala Pro Asn 
    1640                 1645                 1650             


Phe Val  His Gly His Asp Ala  Ser His Leu Ile Leu  Thr Val Cys 
    1655                 1660                 1665             


Asp Leu  Val Asp Lys Gly Ile  Thr Ser Val Ala Val  Ile His Asp 
    1670                 1675                 1680             


Ser Phe  Gly Thr His Ala Gly  Arg Thr Ala Asp Leu  Arg Asp Ser 
    1685                 1690                 1695             


Leu Arg  Glu Glu Met Val Lys  Met Tyr Gln Asn His  Asn Ala Leu 
    1700                 1705                 1710             


Gln Asn  Leu Leu Asp Val His  Glu Glu Arg Trp Leu  Val Asp Thr 
    1715                 1720                 1725             


Gly Ile  Gln Val Pro Glu Gln  Gly Glu Phe Asp Leu  Asn Glu Ile 
    1730                 1735                 1740             


Leu Val  Ser Asp Tyr Cys Phe  Ala 
    1745                 1750     


<210>  3
<211>  7674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant DNA :open-reading frame from pC3P3-G2 plasmid

<400>  3
atggatgctc agaccagacg cagagaacgg cgggcagaga agcaggcaca gtggaaggcc       60

gctaatccgt ttccagttac aacgcaggga tcacaacaaa cgcagccacc acagaggcac      120

tatggcatta cctctcctat cagcttagcg gcccccaagg agactgactg cctactcaca      180

cagaagctca tcgagacgct gaagcccttt ggggtttttg aagaagaaga ggaactgcag      240

cgcaggattt taattttggg aaaattaaat aacctggtga aagaatggat tcgagaaatc      300

agtgaaagca agaatctccc acaatctgta attgaaaatg ttggagggaa gatttttaca      360

tttggatctt acagactagg agtccacacg aaaggtgctg atattgatgc gttgtgtgtt      420

gcaccaagac atgttgatcg aagtgacttt ttcacctcat tctatgataa attgaaatta      480

caagaagaag tgaaagattt aagagctgtt gaagaggcat ttgtaccagt tatcaaactc      540

tgttttgatg gaatagagat tgatattttg tttgcaagat tagcactgca gactattcca      600

gaagatttgg acctacgaga tgacagtctg cttaaaaacc tagatataag atgcataaga      660

agccttaatg gttgcagggt aaccgatgaa attttacatc tagtaccaaa cattgacaac      720

ttcaggttaa ctctgagagc catcaaactg tgggccaaac ggcacaacat ctattccaat      780

atattaggtt tcctcggtgg tgtttcctgg gctatgctag tagcaagaac ttgccagctt      840

tatccaaatg caatagcatc aactcttgta cataaatttt tcttggtatt ttctaaatgg      900

gaatggccaa atccagtgct attgaaacag cctgaagaat gcaatcttaa tttgcctgtg      960

tgggacccaa gggtaaaccc cagtgatagg taccatctta tgcctataat tacaccagca     1020

tacccacagc agaactccac gtacaatgtg tccgtttcaa cacggatggt catggttgag     1080

gagtttaaac aaggtcttgc tatcacagat gaaattttgc tgagtaaggc agagtggtcc     1140

aaactttttg aagctccaaa cttctttcag aagtacaagc attatattgt acttctagca     1200

agtgcgccca cggaaaagca gcgtctggaa tgggtgggct tggtggaatc aaaaatccgc     1260

atcctggttg gaagcttgga gaagaatgag tttattacac tggctcatgt gaatccccag     1320

tcatttccag cccccaaaga aagtcctgac agggaagaat ttcgcacaat gtgggtgatt     1380

gggttagtgt ttaaaaaaac tgaaaactct gaaaatctca gtgtcgacct cacctatgat     1440

atccagtctt tcacagacac agtttatagg caagcaataa acagcaaaat gtttgagttg     1500

gatatgaaga ttgcagcaat gcatgtgaag agaaagcaac tccatcagct gctgcctagt     1560

cacgtgcttc agaagaggaa gaagcattca acagaaggag tcaagttaac agctctgaat     1620

gacagcagcc ttgacttgtc tatggacagt gataacagca tgtctgtgcc ttcacccacc     1680

agtgctatga agaccagtcc attgaatagt tctggcagct cccagggcag aaacagtcct     1740

gctccagctg tgaccgcagc atctgtgacc agcatccagg cttctgaggt ttctgtaccg     1800

caagcaaatt ccagtgaaag cccagggggt ccatcgagcg aaagcattcc tcaaactgcc     1860

acacagccag ccattgcccc accaccaaag cctacagtct ccagagttgt ctcctcaaca     1920

cgactggtaa acccatcgcc tagaccttca ggaaacacag caacaaaagt ccctaatcct     1980

atagtaggag tcaagagaac gtccgccccc aataaagaag aagcccctag aaggaccaaa     2040

acagaagagg atgaaacaag tgaagatgct aactgtcttg ctttgagtgg acatgataaa     2100

acagagacaa aggaacaagt tgatctggag acaagtgcgg ttcaatcaga aactgttccg     2160

gcatcggctt ctctgttggc ctctcagaaa acatccagta cagacctttc tgatatccct     2220

gctctccctg caaatcctat tcctgttatc aagaactcaa taaaactgag actgaatcgg     2280

ggatcaggcc ctcgcccact gctcgcaatc caccctactg aagcaaggca caagcaaaaa     2340

attgtggctc ctgtgaagca gacgctgaac tttgatctgc tgaagctcgc tggcgacgtg     2400

gagtcgaacc ctggccctgc cagcctggac aacctggtgg ccagatacca gcggtgcttc     2460

aacgaccaga gcctgaagaa cagcaccatc gagctggaaa tccggttcca gcagatcaac     2520

ttcctgctgt tcaagaccgt gtacgaggcc ctggtcgccc aggaaatccc cagcaccatc     2580

agccacagca tccggtgcat caagaaggtg caccacgaga accactgccg ggagaagatc     2640

ctgcccagcg agaacctgta cttcaagaaa cagcccctga tgttcttcaa gttcagcgag     2700

cccgccagcc tgggctgtaa agtgtccctg gccatcgagc agcccatccg gaagttcatc     2760

ctggacagca gcgtgctggt ccggctgaag aaccggacca ccttccgggt gtccgagctg     2820

tggaagatcg agctgaccat cgtgaagcag ctgatgggca gcgaggtgtc agccaagctg     2880

gccgccttca agaccctgct gttcgacacc cccgagcagc agaccaccaa gaacatgatg     2940

accctgatca accccgacga cgagtacctg tacgagatcg agatcgagta caccggcaag     3000

cctgagagcc tgacagccgc cgacgtgatc aagatcaaga acaccgtgct gacactgatc     3060

agccccaacc acctgatgct gaccgcctac caccaggcca tcgagtttat cgccagccac     3120

atcctgagca gcgagatcct gctggcccgg atcaagagcg gcaagtgggg cctgaagaga     3180

ctgctgcccc aggtcaagtc catgaccaag gccgactaca tgaagttcta cccccccgtg     3240

ggctactacg tgaccgacaa ggccgacggc atccggggca ttgccgtgat ccaggacacc     3300

cagatctacg tggtggccga ccagctgtac agcctgggca ccaccggcat cgagcccctg     3360

aagcccacca tcctggacgg cgagttcatg cccgagaaga aagagttcta cggctttgac     3420

gtgatcatgt acgagggcaa cctgctgacc cagcagggct tcgagacacg gatcgagagc     3480

ctgagcaagg gcatcaaggt gctgcaggcc ttcaacatca aggccgagat gaagcccttc     3540

atcagcctga cctccgccga ccccaacgtg ctgctgaaga atttcgagag catcttcaag     3600

aagaaaaccc ggccctacag catcgacggc atcatcctgg tggagcccgg caacagctac     3660

ctgaacacca acaccttcaa gtggaagccc acctgggaca acaccctgga ctttctggtc     3720

cggaagtgcc ccgagtccct gaacgtgccc gagtacgccc ccaagaaggg cttcagcctg     3780

catctgctgt tcgtgggcat cagcggcgag ctgtttaaga agctggccct gaactggtgc     3840

cccggctaca ccaagctgtt ccccgtgacc cagcggaacc agaactactt ccccgtgcag     3900

ttccagccca gcgacttccc cctggccttc ctgtactacc accccgacac cagcagcttc     3960

agcaacatcg atggcaaggt gctggaaatg cggtgcctga agcgggagat caactacgtg     4020

cgctgggaga tcgtgaagat ccgggaggac cggcagcagg atctgaaaac cggcggctac     4080

ttcggcaacg acttcaagac cgccgagctg acctggctga actacatgga ccccttcagc     4140

ttcgaggaac tggccaaggg acccagcggc atgtacttcg ctggcgccaa gaccggcatc     4200

tacagagccc agaccgccct gatcagcttc atcaagcagg aaatcatcca gaagatcagc     4260

caccagagct gggtgatcga cctgggcatc ggcaagggcc aggacctggg cagatacctg     4320

gacgccggcg tgagacacct ggtcggcatc gataaggacc agacagccct ggccgagctg     4380

gtgtaccgga agttctccca cgccaccacc agacagcaca agcacgccac caacatctac     4440

gtgctgcacc aggatctggc cgagcctgcc aaagaaatca gcgagaaagt gcaccagatc     4500

tatggcttcc ccaaagaggg cgccagcagc atcgtgtcca acctgttcat ccactacctg     4560

atgaagaaca cccagcaggt cgagaacctg gctgtgctgt gccacaagct gctgcagcct     4620

ggcggcatgg tctggttcac caccatgctg ggcgaacagg tgctggaact gctgcacgag     4680

aaccggatcg aactgaacga agtgtgggag gcccgggaga acgaggtggt caagttcgcc     4740

atcaagcggc tgttcaaaga ggacatcctg caggaaaccg gccaggaaat cggcgtcctg     4800

ctgcccttca gcaacggcga cttctacaat gagtacctgg tcaacaccgc ctttctgatc     4860

aagattttca agcaccatgg ctttagcctc gtgcagaagc agagcttcaa ggactggatc     4920

cccgagttcc agaacttcag caagagcctg tacaagatcc tgaccgaggc cgacaagacc     4980

tggaccagcc tgttcggctt catctgcctg cggaagaacg gaggcggggg aagtggaggg     5040

ggcggcagtc aggacctgca cgccatccag ctgcagctcg aagaggaaat gttcaacggc     5100

ggcatcagaa gattcgaggc cgaccagcag agacagatcg cctctggcaa cgagagcgac     5160

accgcctgga atagaaggct gctgtctgag ctgatcgccc ctatggccga aggcatccag     5220

gcctacaaag aggaatacga gggcaagaga ggcagagccc ctagagccct ggccttcatc     5280

aactgtgtgg gcaatgaggt ggccgcctac atcaccatga agatcgtgat ggacatgctg     5340

aacaccgacg tgaccctgca ggccattgcc atgaacgtgg ccgacagaat cgaggaccag     5400

gtccgattca gcaagctgga aggacacgcc gccaagtact tcgagaaagt gaagaagtcc     5460

ctgaaggcca gcaagaccaa gagctacaga cacgcccaca acgtggccgt ggtggccgaa     5520

aaatctgtgg ccgataggga cgccgacttc tctagatggg aggcctggcc taaggacacc     5580

ctgctgcaga tcggcatgac cctgctggaa atcctggaaa acagcgtgtt cttcaacggc     5640

cagcccgtgt tcctgagaac cctgaggaca aatggcggca agcacggcgt gtactacctg     5700

cagacatctg agcacgtggg cgagtggatc accgccttca aagaacatgt ggcccagctg     5760

agccctgcct atgccccttg tgtgatccct cctagaccct gggtgtcccc tttcaatggc     5820

ggctttcaca ccgagaaggt ggccagcaga atcagactgg tcaagggcaa ccgggaacac     5880

gtgcggaagc tgaccaagaa acagatgccc gccgtgtaca aggccgtgaa tgctctgcag     5940

gccaccaagt ggcaggtcaa caaagaggtg ctgcaggtcg tcgaggacgt gatcagactg     6000

gatctgggct acggcgtgcc aagctttaag cccctgatcg acagagagaa caagcccgcc     6060

aaccctgtgc ccctggaatt tcagcacctg agaggccgcg agctgaaaga gatgctgaca     6120

cctgaacagt ggcaggcctt tatcaattgg aagggcgagt gcaccaagct gtacaccgcc     6180

gagacaaaga ggggctctaa gtctgccgcc acagtgcgaa tggtcggaca ggccagaaag     6240

tacagccagt tcgacgccat ctacttcgtg tacgccctgg acagccggtc tagagtgtat     6300

gcccagagca gcacactgag cccccagtct aacgatctgg gaaaggccct gctgagattc     6360

accgagggcc agagactgga ttctgccgaa gccctgaagt ggttcctggt caacggcgcc     6420

aacaactggg gctgggacaa gaaaaccttc gatgtgcgga ccgccaacgt gctggatagc     6480

gagttccagg acatgtgcag agatatcgcc gccgaccctc tgacctttac ccagtgggtc     6540

aacgccgata gcccctatgg attcctggcc tggtgcttcg agtacgccag atacctggac     6600

gccctggatg agggaaccca ggatcagttc atgacccatc tgcccgtgca ccaggatggc     6660

tcttgttctg gcatccagca ctacagcgcc atgctgagcg atgccgtggg agccaaagcc     6720

gtgaacctga agcctagcga cagcccccag gatatctatg gcgctgtggc ccaggtggtc     6780

atccagaaaa actacgccta catgaacgcc gaggacgccg agacattcac aagcggaagc     6840

gtgacactga caggcgccga gctgagatct atggcctctg cctgggacat gatcggcatc     6900

acacggggcc tgaccaaaaa gcctgtgatg acactgccct acggcagcac cagactgacc     6960

tgtagagaaa gcgtgatcga ctacatcgtg gacctggaag agaaagaggc ccagagagcc     7020

attgccgagg gcagaacagc caatcctgtg caccccttcg acaacgaccg gaaggatagc     7080

ctgacaccta gcgccgccta caactacatg accgccctga tctggcccag catctctgaa     7140

gtggtcaagg cccctatcgt ggccatgaag atgatcagac agctggccag attcgccgcc     7200

aagagaaatg agggcctgga ataccctctg cccaccggct ttatcctgca gcagaaaatc     7260

atggccaccg acatgctgcg ggtgtccaca tgtctgatgg gcgagatcaa gatgagcctg     7320

cagatcgaga cagacgtggt ggacgagaca gccatgatgg gagccgccgc tcctaatttt     7380

gtgcacggac acgatgccag ccacctgatc ctgaccgtgt gcgatctggt ggacaagggc     7440

atcactagcg tggccgtgat ccacgatagc tttggaacac acgccggcag aaccgccgac     7500

ctgagagatt ctctgcggga agagatggtc aagatgtacc agaaccacaa cgccctgcag     7560

aacctgctgg acgtgcacga agaaagatgg ctggtggaca ccggcatcca ggtgccagaa     7620

cagggagagt tcgacctgaa cgagatcctg gtgtccgact actgcttcgc ctga           7674


<210>  4
<211>  2557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant protein encoded by pC3P3-G2 plasmid

<400>  4

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn Pro Phe Pro Val Thr Thr Gln Gly Ser Gln 
            20                  25                  30          


Gln Thr Gln Pro Pro Gln Arg His Tyr Gly Ile Thr Ser Pro Ile Ser 
        35                  40                  45              


Leu Ala Ala Pro Lys Glu Thr Asp Cys Leu Leu Thr Gln Lys Leu Ile 
    50                  55                  60                  


Glu Thr Leu Lys Pro Phe Gly Val Phe Glu Glu Glu Glu Glu Leu Gln 
65                  70                  75                  80  


Arg Arg Ile Leu Ile Leu Gly Lys Leu Asn Asn Leu Val Lys Glu Trp 
                85                  90                  95      


Ile Arg Glu Ile Ser Glu Ser Lys Asn Leu Pro Gln Ser Val Ile Glu 
            100                 105                 110         


Asn Val Gly Gly Lys Ile Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val 
        115                 120                 125             


His Thr Lys Gly Ala Asp Ile Asp Ala Leu Cys Val Ala Pro Arg His 
    130                 135                 140                 


Val Asp Arg Ser Asp Phe Phe Thr Ser Phe Tyr Asp Lys Leu Lys Leu 
145                 150                 155                 160 


Gln Glu Glu Val Lys Asp Leu Arg Ala Val Glu Glu Ala Phe Val Pro 
                165                 170                 175     


Val Ile Lys Leu Cys Phe Asp Gly Ile Glu Ile Asp Ile Leu Phe Ala 
            180                 185                 190         


Arg Leu Ala Leu Gln Thr Ile Pro Glu Asp Leu Asp Leu Arg Asp Asp 
        195                 200                 205             


Ser Leu Leu Lys Asn Leu Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly 
    210                 215                 220                 


Cys Arg Val Thr Asp Glu Ile Leu His Leu Val Pro Asn Ile Asp Asn 
225                 230                 235                 240 


Phe Arg Leu Thr Leu Arg Ala Ile Lys Leu Trp Ala Lys Arg His Asn 
                245                 250                 255     


Ile Tyr Ser Asn Ile Leu Gly Phe Leu Gly Gly Val Ser Trp Ala Met 
            260                 265                 270         


Leu Val Ala Arg Thr Cys Gln Leu Tyr Pro Asn Ala Ile Ala Ser Thr 
        275                 280                 285             


Leu Val His Lys Phe Phe Leu Val Phe Ser Lys Trp Glu Trp Pro Asn 
    290                 295                 300                 


Pro Val Leu Leu Lys Gln Pro Glu Glu Cys Asn Leu Asn Leu Pro Val 
305                 310                 315                 320 


Trp Asp Pro Arg Val Asn Pro Ser Asp Arg Tyr His Leu Met Pro Ile 
                325                 330                 335     


Ile Thr Pro Ala Tyr Pro Gln Gln Asn Ser Thr Tyr Asn Val Ser Val 
            340                 345                 350         


Ser Thr Arg Met Val Met Val Glu Glu Phe Lys Gln Gly Leu Ala Ile 
        355                 360                 365             


Thr Asp Glu Ile Leu Leu Ser Lys Ala Glu Trp Ser Lys Leu Phe Glu 
    370                 375                 380                 


Ala Pro Asn Phe Phe Gln Lys Tyr Lys His Tyr Ile Val Leu Leu Ala 
385                 390                 395                 400 


Ser Ala Pro Thr Glu Lys Gln Arg Leu Glu Trp Val Gly Leu Val Glu 
                405                 410                 415     


Ser Lys Ile Arg Ile Leu Val Gly Ser Leu Glu Lys Asn Glu Phe Ile 
            420                 425                 430         


Thr Leu Ala His Val Asn Pro Gln Ser Phe Pro Ala Pro Lys Glu Ser 
        435                 440                 445             


Pro Asp Arg Glu Glu Phe Arg Thr Met Trp Val Ile Gly Leu Val Phe 
    450                 455                 460                 


Lys Lys Thr Glu Asn Ser Glu Asn Leu Ser Val Asp Leu Thr Tyr Asp 
465                 470                 475                 480 


Ile Gln Ser Phe Thr Asp Thr Val Tyr Arg Gln Ala Ile Asn Ser Lys 
                485                 490                 495     


Met Phe Glu Leu Asp Met Lys Ile Ala Ala Met His Val Lys Arg Lys 
            500                 505                 510         


Gln Leu His Gln Leu Leu Pro Ser His Val Leu Gln Lys Arg Lys Lys 
        515                 520                 525             


His Ser Thr Glu Gly Val Lys Leu Thr Ala Leu Asn Asp Ser Ser Leu 
    530                 535                 540                 


Asp Leu Ser Met Asp Ser Asp Asn Ser Met Ser Val Pro Ser Pro Thr 
545                 550                 555                 560 


Ser Ala Met Lys Thr Ser Pro Leu Asn Ser Ser Gly Ser Ser Gln Gly 
                565                 570                 575     


Arg Asn Ser Pro Ala Pro Ala Val Thr Ala Ala Ser Val Thr Ser Ile 
            580                 585                 590         


Gln Ala Ser Glu Val Ser Val Pro Gln Ala Asn Ser Ser Glu Ser Pro 
        595                 600                 605             


Gly Gly Pro Ser Ser Glu Ser Ile Pro Gln Thr Ala Thr Gln Pro Ala 
    610                 615                 620                 


Ile Ala Pro Pro Pro Lys Pro Thr Val Ser Arg Val Val Ser Ser Thr 
625                 630                 635                 640 


Arg Leu Val Asn Pro Ser Pro Arg Pro Ser Gly Asn Thr Ala Thr Lys 
                645                 650                 655     


Val Pro Asn Pro Ile Val Gly Val Lys Arg Thr Ser Ala Pro Asn Lys 
            660                 665                 670         


Glu Glu Ala Pro Arg Arg Thr Lys Thr Glu Glu Asp Glu Thr Ser Glu 
        675                 680                 685             


Asp Ala Asn Cys Leu Ala Leu Ser Gly His Asp Lys Thr Glu Thr Lys 
    690                 695                 700                 


Glu Gln Val Asp Leu Glu Thr Ser Ala Val Gln Ser Glu Thr Val Pro 
705                 710                 715                 720 


Ala Ser Ala Ser Leu Leu Ala Ser Gln Lys Thr Ser Ser Thr Asp Leu 
                725                 730                 735     


Ser Asp Ile Pro Ala Leu Pro Ala Asn Pro Ile Pro Val Ile Lys Asn 
            740                 745                 750         


Ser Ile Lys Leu Arg Leu Asn Arg Gly Ser Gly Pro Arg Pro Leu Leu 
        755                 760                 765             


Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro 
    770                 775                 780                 


Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
785                 790                 795                 800 


Glu Ser Asn Pro Gly Pro Ala Ser Leu Asp Asn Leu Val Ala Arg Tyr 
                805                 810                 815     


Gln Arg Cys Phe Asn Asp Gln Ser Leu Lys Asn Ser Thr Ile Glu Leu 
            820                 825                 830         


Glu Ile Arg Phe Gln Gln Ile Asn Phe Leu Leu Phe Lys Thr Val Tyr 
        835                 840                 845             


Glu Ala Leu Val Ala Gln Glu Ile Pro Ser Thr Ile Ser His Ser Ile 
    850                 855                 860                 


Arg Cys Ile Lys Lys Val His His Glu Asn His Cys Arg Glu Lys Ile 
865                 870                 875                 880 


Leu Pro Ser Glu Asn Leu Tyr Phe Lys Lys Gln Pro Leu Met Phe Phe 
                885                 890                 895     


Lys Phe Ser Glu Pro Ala Ser Leu Gly Cys Lys Val Ser Leu Ala Ile 
            900                 905                 910         


Glu Gln Pro Ile Arg Lys Phe Ile Leu Asp Ser Ser Val Leu Val Arg 
        915                 920                 925             


Leu Lys Asn Arg Thr Thr Phe Arg Val Ser Glu Leu Trp Lys Ile Glu 
    930                 935                 940                 


Leu Thr Ile Val Lys Gln Leu Met Gly Ser Glu Val Ser Ala Lys Leu 
945                 950                 955                 960 


Ala Ala Phe Lys Thr Leu Leu Phe Asp Thr Pro Glu Gln Gln Thr Thr 
                965                 970                 975     


Lys Asn Met Met Thr Leu Ile Asn Pro Asp Asp Glu Tyr Leu Tyr Glu 
            980                 985                 990         


Ile Glu Ile Glu Tyr Thr Gly Lys  Pro Glu Ser Leu Thr  Ala Ala Asp 
        995                 1000                 1005             


Val Ile  Lys Ile Lys Asn Thr  Val Leu Thr Leu Ile  Ser Pro Asn 
    1010                 1015                 1020             


His Leu  Met Leu Thr Ala Tyr  His Gln Ala Ile Glu  Phe Ile Ala 
    1025                 1030                 1035             


Ser His  Ile Leu Ser Ser Glu  Ile Leu Leu Ala Arg  Ile Lys Ser 
    1040                 1045                 1050             


Gly Lys  Trp Gly Leu Lys Arg  Leu Leu Pro Gln Val  Lys Ser Met 
    1055                 1060                 1065             


Thr Lys  Ala Asp Tyr Met Lys  Phe Tyr Pro Pro Val  Gly Tyr Tyr 
    1070                 1075                 1080             


Val Thr  Asp Lys Ala Asp Gly  Ile Arg Gly Ile Ala  Val Ile Gln 
    1085                 1090                 1095             


Asp Thr  Gln Ile Tyr Val Val  Ala Asp Gln Leu Tyr  Ser Leu Gly 
    1100                 1105                 1110             


Thr Thr  Gly Ile Glu Pro Leu  Lys Pro Thr Ile Leu  Asp Gly Glu 
    1115                 1120                 1125             


Phe Met  Pro Glu Lys Lys Glu  Phe Tyr Gly Phe Asp  Val Ile Met 
    1130                 1135                 1140             


Tyr Glu  Gly Asn Leu Leu Thr  Gln Gln Gly Phe Glu  Thr Arg Ile 
    1145                 1150                 1155             


Glu Ser  Leu Ser Lys Gly Ile  Lys Val Leu Gln Ala  Phe Asn Ile 
    1160                 1165                 1170             


Lys Ala  Glu Met Lys Pro Phe  Ile Ser Leu Thr Ser  Ala Asp Pro 
    1175                 1180                 1185             


Asn Val  Leu Leu Lys Asn Phe  Glu Ser Ile Phe Lys  Lys Lys Thr 
    1190                 1195                 1200             


Arg Pro  Tyr Ser Ile Asp Gly  Ile Ile Leu Val Glu  Pro Gly Asn 
    1205                 1210                 1215             


Ser Tyr  Leu Asn Thr Asn Thr  Phe Lys Trp Lys Pro  Thr Trp Asp 
    1220                 1225                 1230             


Asn Thr  Leu Asp Phe Leu Val  Arg Lys Cys Pro Glu  Ser Leu Asn 
    1235                 1240                 1245             


Val Pro  Glu Tyr Ala Pro Lys  Lys Gly Phe Ser Leu  His Leu Leu 
    1250                 1255                 1260             


Phe Val  Gly Ile Ser Gly Glu  Leu Phe Lys Lys Leu  Ala Leu Asn 
    1265                 1270                 1275             


Trp Cys  Pro Gly Tyr Thr Lys  Leu Phe Pro Val Thr  Gln Arg Asn 
    1280                 1285                 1290             


Gln Asn  Tyr Phe Pro Val Gln  Phe Gln Pro Ser Asp  Phe Pro Leu 
    1295                 1300                 1305             


Ala Phe  Leu Tyr Tyr His Pro  Asp Thr Ser Ser Phe  Ser Asn Ile 
    1310                 1315                 1320             


Asp Gly  Lys Val Leu Glu Met  Arg Cys Leu Lys Arg  Glu Ile Asn 
    1325                 1330                 1335             


Tyr Val  Arg Trp Glu Ile Val  Lys Ile Arg Glu Asp  Arg Gln Gln 
    1340                 1345                 1350             


Asp Leu  Lys Thr Gly Gly Tyr  Phe Gly Asn Asp Phe  Lys Thr Ala 
    1355                 1360                 1365             


Glu Leu  Thr Trp Leu Asn Tyr  Met Asp Pro Phe Ser  Phe Glu Glu 
    1370                 1375                 1380             


Leu Ala  Lys Gly Pro Ser Gly  Met Tyr Phe Ala Gly  Ala Lys Thr 
    1385                 1390                 1395             


Gly Ile  Tyr Arg Ala Gln Thr  Ala Leu Ile Ser Phe  Ile Lys Gln 
    1400                 1405                 1410             


Glu Ile  Ile Gln Lys Ile Ser  His Gln Ser Trp Val  Ile Asp Leu 
    1415                 1420                 1425             


Gly Ile  Gly Lys Gly Gln Asp  Leu Gly Arg Tyr Leu  Asp Ala Gly 
    1430                 1435                 1440             


Val Arg  His Leu Val Gly Ile  Asp Lys Asp Gln Thr  Ala Leu Ala 
    1445                 1450                 1455             


Glu Leu  Val Tyr Arg Lys Phe  Ser His Ala Thr Thr  Arg Gln His 
    1460                 1465                 1470             


Lys His  Ala Thr Asn Ile Tyr  Val Leu His Gln Asp  Leu Ala Glu 
    1475                 1480                 1485             


Pro Ala  Lys Glu Ile Ser Glu  Lys Val His Gln Ile  Tyr Gly Phe 
    1490                 1495                 1500             


Pro Lys  Glu Gly Ala Ser Ser  Ile Val Ser Asn Leu  Phe Ile His 
    1505                 1510                 1515             


Tyr Leu  Met Lys Asn Thr Gln  Gln Val Glu Asn Leu  Ala Val Leu 
    1520                 1525                 1530             


Cys His  Lys Leu Leu Gln Pro  Gly Gly Met Val Trp  Phe Thr Thr 
    1535                 1540                 1545             


Met Leu  Gly Glu Gln Val Leu  Glu Leu Leu His Glu  Asn Arg Ile 
    1550                 1555                 1560             


Glu Leu  Asn Glu Val Trp Glu  Ala Arg Glu Asn Glu  Val Val Lys 
    1565                 1570                 1575             


Phe Ala  Ile Lys Arg Leu Phe  Lys Glu Asp Ile Leu  Gln Glu Thr 
    1580                 1585                 1590             


Gly Gln  Glu Ile Gly Val Leu  Leu Pro Phe Ser Asn  Gly Asp Phe 
    1595                 1600                 1605             


Tyr Asn  Glu Tyr Leu Val Asn  Thr Ala Phe Leu Ile  Lys Ile Phe 
    1610                 1615                 1620             


Lys His  His Gly Phe Ser Leu  Val Gln Lys Gln Ser  Phe Lys Asp 
    1625                 1630                 1635             


Trp Ile  Pro Glu Phe Gln Asn  Phe Ser Lys Ser Leu  Tyr Lys Ile 
    1640                 1645                 1650             


Leu Thr  Glu Ala Asp Lys Thr  Trp Thr Ser Leu Phe  Gly Phe Ile 
    1655                 1660                 1665             


Cys Leu  Arg Lys Asn Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1670                 1675                 1680             


Gln Asp  Leu His Ala Ile Gln  Leu Gln Leu Glu Glu  Glu Met Phe 
    1685                 1690                 1695             


Asn Gly  Gly Ile Arg Arg Phe  Glu Ala Asp Gln Gln  Arg Gln Ile 
    1700                 1705                 1710             


Ala Ser  Gly Asn Glu Ser Asp  Thr Ala Trp Asn Arg  Arg Leu Leu 
    1715                 1720                 1725             


Ser Glu  Leu Ile Ala Pro Met  Ala Glu Gly Ile Gln  Ala Tyr Lys 
    1730                 1735                 1740             


Glu Glu  Tyr Glu Gly Lys Arg  Gly Arg Ala Pro Arg  Ala Leu Ala 
    1745                 1750                 1755             


Phe Ile  Asn Cys Val Gly Asn  Glu Val Ala Ala Tyr  Ile Thr Met 
    1760                 1765                 1770             


Lys Ile  Val Met Asp Met Leu  Asn Thr Asp Val Thr  Leu Gln Ala 
    1775                 1780                 1785             


Ile Ala  Met Asn Val Ala Asp  Arg Ile Glu Asp Gln  Val Arg Phe 
    1790                 1795                 1800             


Ser Lys  Leu Glu Gly His Ala  Ala Lys Tyr Phe Glu  Lys Val Lys 
    1805                 1810                 1815             


Lys Ser  Leu Lys Ala Ser Lys  Thr Lys Ser Tyr Arg  His Ala His 
    1820                 1825                 1830             


Asn Val  Ala Val Val Ala Glu  Lys Ser Val Ala Asp  Arg Asp Ala 
    1835                 1840                 1845             


Asp Phe  Ser Arg Trp Glu Ala  Trp Pro Lys Asp Thr  Leu Leu Gln 
    1850                 1855                 1860             


Ile Gly  Met Thr Leu Leu Glu  Ile Leu Glu Asn Ser  Val Phe Phe 
    1865                 1870                 1875             


Asn Gly  Gln Pro Val Phe Leu  Arg Thr Leu Arg Thr  Asn Gly Gly 
    1880                 1885                 1890             


Lys His  Gly Val Tyr Tyr Leu  Gln Thr Ser Glu His  Val Gly Glu 
    1895                 1900                 1905             


Trp Ile  Thr Ala Phe Lys Glu  His Val Ala Gln Leu  Ser Pro Ala 
    1910                 1915                 1920             


Tyr Ala  Pro Cys Val Ile Pro  Pro Arg Pro Trp Val  Ser Pro Phe 
    1925                 1930                 1935             


Asn Gly  Gly Phe His Thr Glu  Lys Val Ala Ser Arg  Ile Arg Leu 
    1940                 1945                 1950             


Val Lys  Gly Asn Arg Glu His  Val Arg Lys Leu Thr  Lys Lys Gln 
    1955                 1960                 1965             


Met Pro  Ala Val Tyr Lys Ala  Val Asn Ala Leu Gln  Ala Thr Lys 
    1970                 1975                 1980             


Trp Gln  Val Asn Lys Glu Val  Leu Gln Val Val Glu  Asp Val Ile 
    1985                 1990                 1995             


Arg Leu  Asp Leu Gly Tyr Gly  Val Pro Ser Phe Lys  Pro Leu Ile 
    2000                 2005                 2010             


Asp Arg  Glu Asn Lys Pro Ala  Asn Pro Val Pro Leu  Glu Phe Gln 
    2015                 2020                 2025             


His Leu  Arg Gly Arg Glu Leu  Lys Glu Met Leu Thr  Pro Glu Gln 
    2030                 2035                 2040             


Trp Gln  Ala Phe Ile Asn Trp  Lys Gly Glu Cys Thr  Lys Leu Tyr 
    2045                 2050                 2055             


Thr Ala  Glu Thr Lys Arg Gly  Ser Lys Ser Ala Ala  Thr Val Arg 
    2060                 2065                 2070             


Met Val  Gly Gln Ala Arg Lys  Tyr Ser Gln Phe Asp  Ala Ile Tyr 
    2075                 2080                 2085             


Phe Val  Tyr Ala Leu Asp Ser  Arg Ser Arg Val Tyr  Ala Gln Ser 
    2090                 2095                 2100             


Ser Thr  Leu Ser Pro Gln Ser  Asn Asp Leu Gly Lys  Ala Leu Leu 
    2105                 2110                 2115             


Arg Phe  Thr Glu Gly Gln Arg  Leu Asp Ser Ala Glu  Ala Leu Lys 
    2120                 2125                 2130             


Trp Phe  Leu Val Asn Gly Ala  Asn Asn Trp Gly Trp  Asp Lys Lys 
    2135                 2140                 2145             


Thr Phe  Asp Val Arg Thr Ala  Asn Val Leu Asp Ser  Glu Phe Gln 
    2150                 2155                 2160             


Asp Met  Cys Arg Asp Ile Ala  Ala Asp Pro Leu Thr  Phe Thr Gln 
    2165                 2170                 2175             


Trp Val  Asn Ala Asp Ser Pro  Tyr Gly Phe Leu Ala  Trp Cys Phe 
    2180                 2185                 2190             


Glu Tyr  Ala Arg Tyr Leu Asp  Ala Leu Asp Glu Gly  Thr Gln Asp 
    2195                 2200                 2205             


Gln Phe  Met Thr His Leu Pro  Val His Gln Asp Gly  Ser Cys Ser 
    2210                 2215                 2220             


Gly Ile  Gln His Tyr Ser Ala  Met Leu Ser Asp Ala  Val Gly Ala 
    2225                 2230                 2235             


Lys Ala  Val Asn Leu Lys Pro  Ser Asp Ser Pro Gln  Asp Ile Tyr 
    2240                 2245                 2250             


Gly Ala  Val Ala Gln Val Val  Ile Gln Lys Asn Tyr  Ala Tyr Met 
    2255                 2260                 2265             


Asn Ala  Glu Asp Ala Glu Thr  Phe Thr Ser Gly Ser  Val Thr Leu 
    2270                 2275                 2280             


Thr Gly  Ala Glu Leu Arg Ser  Met Ala Ser Ala Trp  Asp Met Ile 
    2285                 2290                 2295             


Gly Ile  Thr Arg Gly Leu Thr  Lys Lys Pro Val Met  Thr Leu Pro 
    2300                 2305                 2310             


Tyr Gly  Ser Thr Arg Leu Thr  Cys Arg Glu Ser Val  Ile Asp Tyr 
    2315                 2320                 2325             


Ile Val  Asp Leu Glu Glu Lys  Glu Ala Gln Arg Ala  Ile Ala Glu 
    2330                 2335                 2340             


Gly Arg  Thr Ala Asn Pro Val  His Pro Phe Asp Asn  Asp Arg Lys 
    2345                 2350                 2355             


Asp Ser  Leu Thr Pro Ser Ala  Ala Tyr Asn Tyr Met  Thr Ala Leu 
    2360                 2365                 2370             


Ile Trp  Pro Ser Ile Ser Glu  Val Val Lys Ala Pro  Ile Val Ala 
    2375                 2380                 2385             


Met Lys  Met Ile Arg Gln Leu  Ala Arg Phe Ala Ala  Lys Arg Asn 
    2390                 2395                 2400             


Glu Gly  Leu Glu Tyr Pro Leu  Pro Thr Gly Phe Ile  Leu Gln Gln 
    2405                 2410                 2415             


Lys Ile  Met Ala Thr Asp Met  Leu Arg Val Ser Thr  Cys Leu Met 
    2420                 2425                 2430             


Gly Glu  Ile Lys Met Ser Leu  Gln Ile Glu Thr Asp  Val Val Asp 
    2435                 2440                 2445             


Glu Thr  Ala Met Met Gly Ala  Ala Ala Pro Asn Phe  Val His Gly 
    2450                 2455                 2460             


His Asp  Ala Ser His Leu Ile  Leu Thr Val Cys Asp  Leu Val Asp 
    2465                 2470                 2475             


Lys Gly  Ile Thr Ser Val Ala  Val Ile His Asp Ser  Phe Gly Thr 
    2480                 2485                 2490             


His Ala  Gly Arg Thr Ala Asp  Leu Arg Asp Ser Leu  Arg Glu Glu 
    2495                 2500                 2505             


Met Val  Lys Met Tyr Gln Asn  His Asn Ala Leu Gln  Asn Leu Leu 
    2510                 2515                 2520             


Asp Val  His Glu Glu Arg Trp  Leu Val Asp Thr Gly  Ile Gln Val 
    2525                 2530                 2535             


Pro Glu  Gln Gly Glu Phe Asp  Leu Asn Glu Ile Leu  Val Ser Asp 
    2540                 2545                 2550             


Tyr Cys  Phe Ala 
    2555         


<210>  5
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant DNA: open-reading frame from 
       pADAR1-Zalpha/(G4S)2/E3L-dsDNA plasmid

<400>  5
atgctgtcca tctaccaaga ccaagaacag aggatactca aatttttgga ggaattgggt       60

gagggaaagg ccaccactgc acacgatttg tctgggaaac tcgggacccc aaaaaaggag      120

attaacaggg ttctgtactc cctggctaag aaaggcaaat tgcagaaaga agccggaact      180

ccccctctgt ggaagatcgc agtgagcaca caagcttgga atcaacatag cggagtcgtg      240

cgacccgatg gtcattcaca gggcgccccg aactccgacc cctccctaga accagaggac      300

aggaattcaa cgagcgtgag tgaagacctg cttgaaccgt tcatagctgt ctctgcacag      360

gcatggaatc agcactccgg tgtggtgaga cccgactctc atagccaggg aagccccaac      420

agcgacccgg gtctcgagcc tgaagactct aattcgacta gtgctcttga ggatccattg      480

gaatttctcg atatggcaga aatcaaggaa aaaatttgcg attacctttt taacgtctct      540

gatagcagcg ctctgaacct ggctaaaaat ataggtctta ccaaagctcg tgatatcaat      600

gccgtgctga tcgatatgga gcggcaggga gacgtatatc gccagggcac tactccccca      660

atctggcacc tcacggatgg aggaggaggc tctggtggtg gcgggagcaa ccccgtgacc      720

atcatcaacg agtactgcca gatcaccaag agagactgga gcttcagaat cgagagcgtg      780

ggccccagca acagccccac cttctacgcc tgcgtggaca tcgacggcag agtgttcgac      840

aaggccgacg gcaagagcaa gagagacgcc aagaacaacg ccgccaagct ggccgtggac      900

aagctgctgg gctacgtgat catcagattc tga                                   933


<210>  6
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pADAR1-Zalpha/(G4S)2/E3L-dsDNA 
       plasmid

<400>  6

Met Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu Lys Phe Leu 
1               5                   10                  15      


Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp Leu Ser Gly 
            20                  25                  30          


Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu Tyr Ser Leu 
        35                  40                  45              


Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro Pro Leu Trp 
    50                  55                  60                  


Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser Gly Val Val 
65                  70                  75                  80  


Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp Pro Ser Leu 
                85                  90                  95      


Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp Leu Leu Glu 
            100                 105                 110         


Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His Ser Gly Val 
        115                 120                 125             


Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser Asp Pro Gly 
    130                 135                 140                 


Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu Asp Pro Leu 
145                 150                 155                 160 


Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu 
                165                 170                 175     


Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly 
            180                 185                 190         


Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg 
        195                 200                 205             


Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu 
    210                 215                 220                 


Thr Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Pro Val Thr 
225                 230                 235                 240 


Ile Ile Asn Glu Tyr Cys Gln Ile Thr Lys Arg Asp Trp Ser Phe Arg 
                245                 250                 255     


Ile Glu Ser Val Gly Pro Ser Asn Ser Pro Thr Phe Tyr Ala Cys Val 
            260                 265                 270         


Asp Ile Asp Gly Arg Val Phe Asp Lys Ala Asp Gly Lys Ser Lys Arg 
        275                 280                 285             


Asp Ala Lys Asn Asn Ala Ala Lys Leu Ala Val Asp Lys Leu Leu Gly 
    290                 295                 300                 


Tyr Val Ile Ile Arg Phe 
305                 310 


<210>  7
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pE3L-Zalpha/NS1-dsDNA 
       plasmid

<400>  7
atgagcaaga tctacatcga cgagagaagc gacgccgaga tcgtgtgcgc cgccatcaag       60

aacatcggca tcgagggcgc caccgccgcc cagctgacca gacagctgaa catggagaag      120

agagaggtga acaaggccct gtacgacctg cagagaagcg ccatggtgta cagcagcgac      180

gacatccccc ccagatggtt catgaccacc gaggccgaca agcccgacgc cgacgccatg      240

gccgacgtga tcatcgacga cgtgagcaga gagaagagca tgagagagga ccacaagagc      300

ttcgacgacg tgatccccgc caagaagatc atcgactgga aggacgccga ccccaataca      360

gtctcctctt ttcaagtgga ctgttttttg tggcatgttc gaaagcgggt tgctgaccaa      420

gagctggggg atgccccgtt tctagaccgg ctacggagag accaaaagag cttgcgtggg      480

agaggcagta ccctgggcct cgacatcgag accgctacac gcgccggcaa gcagatcgtg      540

gaacgcatct taaaagagga gtcctaa                                          567


<210>  8
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pE3L-Zalpha/NS1-dsDNA plasmid

<400>  8

Met Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val Cys 
1               5                   10                  15      


Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln Leu 
            20                  25                  30          


Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu Tyr 
        35                  40                  45              


Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro Pro 
    50                  55                  60                  


Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala Met 
65                  70                  75                  80  


Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg Glu 
                85                  90                  95      


Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile Asp 
            100                 105                 110         


Trp Lys Asp Ala Asp Pro Asn Thr Val Ser Ser Phe Gln Val Asp Cys 
        115                 120                 125             


Phe Leu Trp His Val Arg Lys Arg Val Ala Asp Gln Glu Leu Gly Asp 
    130                 135                 140                 


Ala Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly 
145                 150                 155                 160 


Arg Gly Ser Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr Arg Ala Gly 
                165                 170                 175     


Lys Gln Ile Val Glu Arg Ile Leu Lys Glu Glu Ser 
            180                 185             


<210>  9
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pE3L-Zalpha/B2-dsDNA 
       plasmid

<400>  9
atgagcaaga tctacatcga cgagagaagc gacgccgaga tcgtgtgcgc cgccatcaag       60

aacatcggca tcgagggcgc caccgccgcc cagctgacca gacagctgaa catggagaag      120

agagaggtga acaaggccct gtacgacctg cagagaagcg ccatggtgta cagcagcgac      180

gacatccccc ccagatggtt catgaccacc gaggccgaca agcccgacgc cgacgccatg      240

gccgacgtga tcatcgacga cgtgagcaga gagaagagca tgagagagga ccacaagagc      300

ttcgacgacg tgatccccgc caagaagatc atcgactgga aggacgcccc ctctaaattg      360

gcattgatcc aggagctgcc cgataggatt caaacagccg tggaagcagc catgggaatg      420

tcataccagg atgcaccaaa caatgttaga agagacctgg acaatttgca tgcctgcctt      480

aacaaagcaa agctcactgt gtccagaatg gtgactagcc tgttggaaaa accatccgtc      540

gtcgcgtacc tggagggaaa ggcataa                                          567


<210>  10
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pE3L-Zalpha/B2-dsDNA plasmid

<400>  10

Met Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val Cys 
1               5                   10                  15      


Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln Leu 
            20                  25                  30          


Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu Tyr 
        35                  40                  45              


Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro Pro 
    50                  55                  60                  


Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala Met 
65                  70                  75                  80  


Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg Glu 
                85                  90                  95      


Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile Asp 
            100                 105                 110         


Trp Lys Asp Ala Pro Ser Lys Leu Ala Leu Ile Gln Glu Leu Pro Asp 
        115                 120                 125             


Arg Ile Gln Thr Ala Val Glu Ala Ala Met Gly Met Ser Tyr Gln Asp 
    130                 135                 140                 


Ala Pro Asn Asn Val Arg Arg Asp Leu Asp Asn Leu His Ala Cys Leu 
145                 150                 155                 160 


Asn Lys Ala Lys Leu Thr Val Ser Arg Met Val Thr Ser Leu Leu Glu 
                165                 170                 175     


Lys Pro Ser Val Val Ala Tyr Leu Glu Gly Lys Ala 
            180                 185             


<210>  11
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from 
       pE3L-Zalpha/hEIF2AK2-dsDNA plasmid

<400>  11
atgagcaaga tctacatcga cgagagaagc gacgccgaga tcgtgtgcgc cgccatcaag       60

aacatcggca tcgagggcgc caccgccgcc cagctgacca gacagctgaa catggagaag      120

agagaggtga acaaggccct gtacgacctg cagagaagcg ccatggtgta cagcagcgac      180

gacatccccc ccagatggtt catgaccacc gaggccgaca agcccgacgc cgacgccatg      240

gccgacgtga tcatcgacga cgtgagcaga gagaagagca tgagagagga ccacaagagc      300

ttcgacgacg tgatccccgc caagaagatc atcgactgga aggacgcctt cttcatggag      360

gaactgaaca cataccggca gaagcagggc gttgtgctga agtaccagga actgccgaat      420

tcaggtcctc cccatgatcg ccggttcacg tttcaggtaa taatcgacgg cagggaattc      480

cccgaaggcg agggcagatc taagaaggaa gcgaagaatg ccgcggccaa gttggctgtc      540

gaaatactta ataaagaaaa gaaggctgtc agtccactgc ttctgacaac aactaatagt      600

agcgaaggac taagcatggg aaattacatc ggtctaatca atcggattgc tcagaaaaaa      660

cgccttactg tgaattatga gcagtgcgcc tccggagttc acggacctga gggattccac      720

tacaagtgca agatgggcca aaaggagtat agcatcggca ctgggtctac taaacaagag      780

gctaagcagc tggccgcaaa gctggcgtat ctacagatcc tgagttaa                   828


<210>  12
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pE3L-Zalpha/hEIF2AK2-dsDNA plasmid

<400>  12

Met Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val Cys 
1               5                   10                  15      


Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln Leu 
            20                  25                  30          


Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu Tyr 
        35                  40                  45              


Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro Pro 
    50                  55                  60                  


Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala Met 
65                  70                  75                  80  


Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg Glu 
                85                  90                  95      


Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile Asp 
            100                 105                 110         


Trp Lys Asp Ala Phe Phe Met Glu Glu Leu Asn Thr Tyr Arg Gln Lys 
        115                 120                 125             


Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn Ser Gly Pro Pro 
    130                 135                 140                 


His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp Gly Arg Glu Phe 
145                 150                 155                 160 


Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys Asn Ala Ala Ala 
                165                 170                 175     


Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys Ala Val Ser Pro 
            180                 185                 190         


Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu Ser Met Gly Asn 
        195                 200                 205             


Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys Arg Leu Thr Val 
    210                 215                 220                 


Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro Glu Gly Phe His 
225                 230                 235                 240 


Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile Gly Thr Gly Ser 
                245                 250                 255     


Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu Ala Tyr Leu Gln 
            260                 265                 270         


Ile Leu Ser 
        275 


<210>  13
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pE3L-Zalpha/sigma3-dsDNA
       plasmid

<400>  13
atgagcaaga tctacatcga cgagagaagc gacgccgaga tcgtgtgcgc cgccatcaag       60

aacatcggca tcgagggcgc caccgccgcc cagctgacca gacagctgaa catggagaag      120

agagaggtga acaaggccct gtacgacctg cagagaagcg ccatggtgta cagcagcgac      180

gacatccccc ccagatggtt catgaccacc gaggccgaca agcccgacgc cgacgccatg      240

gccgacgtga tcatcgacga cgtgagcaga gagaagagca tgagagagga ccacaagagc      300

ttcgacgacg tgatccccgc caagaagatc atcgactgga aggacgccgt gtatgactat      360

tctgagctag agcatgatcc tagtaagggg cgggcctatc ggaaggaatt agttacccct      420

gctagagact tcgggcattt tggccttagt cactactcta gagcgactac ccctatcctt      480

gggaagatgc cggctgtctt tagtggaatg ttgaccggca actgtaagat gtatccgttt      540

ataaaaggga cggccaaact gaagacagtg cgcaaactcg tagactccgt gaatcacgcc      600

tga                                                                    603


<210>  14
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pE3L-Zalpha/sigma3-dsDNA plasmid

<400>  14

Met Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val Cys 
1               5                   10                  15      


Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln Leu 
            20                  25                  30          


Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu Tyr 
        35                  40                  45              


Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro Pro 
    50                  55                  60                  


Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala Met 
65                  70                  75                  80  


Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg Glu 
                85                  90                  95      


Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile Asp 
            100                 105                 110         


Trp Lys Asp Ala Val Tyr Asp Tyr Ser Glu Leu Glu His Asp Pro Ser 
        115                 120                 125             


Lys Gly Arg Ala Tyr Arg Lys Glu Leu Val Thr Pro Ala Arg Asp Phe 
    130                 135                 140                 


Gly His Phe Gly Leu Ser His Tyr Ser Arg Ala Thr Thr Pro Ile Leu 
145                 150                 155                 160 


Gly Lys Met Pro Ala Val Phe Ser Gly Met Leu Thr Gly Asn Cys Lys 
                165                 170                 175     


Met Tyr Pro Phe Ile Lys Gly Thr Ala Lys Leu Lys Thr Val Arg Lys 
            180                 185                 190         


Leu Val Asp Ser Val Asn His Ala 
        195                 200 


<210>  15
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from 
       pE3L-Zalpha/NS1-dsDNA/(G4S)2/SZIP plasmid

<400>  15
atgagcaaga tctacatcga cgagagaagc gacgccgaga tcgtgtgcgc cgccatcaag       60

aacatcggca tcgagggcgc caccgccgcc cagctgacca gacagctgaa catggagaag      120

agagaggtga acaaggccct gtacgacctg cagagaagcg ccatggtgta cagcagcgac      180

gacatccccc ccagatggtt catgaccacc gaggccgaca agcccgacgc cgacgccatg      240

gccgacgtga tcatcgacga cgtgagcaga gagaagagca tgagagagga ccacaagagc      300

ttcgacgacg tgatccccgc caagaagatc atcgactgga aggacgccga ccccaataca      360

gtctcctctt ttcaagtgga ctgttttttg tggcatgttc gaaagcgggt tgctgaccaa      420

gagctggggg atgccccgtt tctagaccgg ctacggagag accaaaagag cttgcgtggg      480

agaggcagta ccctgggcct cgacatcgag accgctacac gcgccggcaa gcagatcgtg      540

gaacgcatct taaaagagga gtccggagga ggaggctctg gtggtggcgg gagcaggatg      600

gctcagttgg aggctaaggt agaggaacta ttgtccaaaa attggaatct cgagaacgaa      660

gtagctcgcc tcaagaaact ggtcggcgag cgctaa                                696


<210>  16
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pE3L-Zaalpha/NS1-dsDNA/(G4S)2/SZIP
       plasmid

<400>  16

Met Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val Cys 
1               5                   10                  15      


Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln Leu 
            20                  25                  30          


Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu Tyr 
        35                  40                  45              


Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro Pro 
    50                  55                  60                  


Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala Met 
65                  70                  75                  80  


Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg Glu 
                85                  90                  95      


Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile Asp 
            100                 105                 110         


Trp Lys Asp Ala Asp Pro Asn Thr Val Ser Ser Phe Gln Val Asp Cys 
        115                 120                 125             


Phe Leu Trp His Val Arg Lys Arg Val Ala Asp Gln Glu Leu Gly Asp 
    130                 135                 140                 


Ala Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly 
145                 150                 155                 160 


Arg Gly Ser Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr Arg Ala Gly 
                165                 170                 175     


Lys Gln Ile Val Glu Arg Ile Leu Lys Glu Glu Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Arg Met Ala Gln Leu Glu Ala Lys Val Glu 
        195                 200                 205             


Glu Leu Leu Ser Lys Asn Trp Asn Leu Glu Asn Glu Val Ala Arg Leu 
    210                 215                 220                 


Lys Lys Leu Val Gly Glu Arg 
225                 230     


<210>  17
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from 
       pE3L-Zalpha/NS1-dsDNA/(G4S)2/GCN4 plasmid

<400>  17
atgagcaaga tctacatcga cgagagaagc gacgccgaga tcgtgtgcgc cgccatcaag       60

aacatcggca tcgagggcgc caccgccgcc cagctgacca gacagctgaa catggagaag      120

agagaggtga acaaggccct gtacgacctg cagagaagcg ccatggtgta cagcagcgac      180

gacatccccc ccagatggtt catgaccacc gaggccgaca agcccgacgc cgacgccatg      240

gccgacgtga tcatcgacga cgtgagcaga gagaagagca tgagagagga ccacaagagc      300

ttcgacgacg tgatccccgc caagaagatc atcgactgga aggacgccga ccccaataca      360

gtctcctctt ttcaagtgga ctgttttttg tggcatgttc gaaagcgggt tgctgaccaa      420

gagctggggg atgccccgtt tctagaccgg ctacggagag accaaaagag cttgcgtggg      480

agaggcagta ccctgggcct cgacatcgag accgctacac gcgccggcaa gcagatcgtg      540

gaacgcatct taaaagagga gtccggagga ggaggctctg gtggtggcgg gagcatgaag      600

gtcaagcaac tggaagacgt tgtggaggag ttactctccg taaactatca cctggagaat      660

gtagttgccc gcctgaagaa actggtcggg gagagatga                             699


<210>  18
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pE3L-Zalpha/NS1-dsDNA/(G4S)2/GCN4 
       plasmid

<400>  18

Met Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val Cys 
1               5                   10                  15      


Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln Leu 
            20                  25                  30          


Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu Tyr 
        35                  40                  45              


Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro Pro 
    50                  55                  60                  


Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala Met 
65                  70                  75                  80  


Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg Glu 
                85                  90                  95      


Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile Asp 
            100                 105                 110         


Trp Lys Asp Ala Asp Pro Asn Thr Val Ser Ser Phe Gln Val Asp Cys 
        115                 120                 125             


Phe Leu Trp His Val Arg Lys Arg Val Ala Asp Gln Glu Leu Gly Asp 
    130                 135                 140                 


Ala Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly 
145                 150                 155                 160 


Arg Gly Ser Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr Arg Ala Gly 
                165                 170                 175     


Lys Gln Ile Val Glu Arg Ile Leu Lys Glu Glu Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Met Lys Val Lys Gln Leu Glu Asp Val Val 
        195                 200                 205             


Glu Glu Leu Leu Ser Val Asn Tyr His Leu Glu Asn Val Val Ala Arg 
    210                 215                 220                 


Leu Lys Lys Leu Val Gly Glu Arg 
225                 230         


<210>  19
<211>  8502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pC3P3-G3a plasmid

<400>  19
atggatgctc agaccagacg cagagaacgg cgggcagaga agcaggcaca gtggaaggcc       60

gctaatccgt ttccagttac aacgcaggga tcacaacaaa cgcagccacc acagaggcac      120

tatggcatta cctctcctat cagcttagcg gcccccaagg agactgactg cctactcaca      180

cagaagctca tcgagacgct gaagcccttt ggggtttttg aagaagaaga ggaactgcag      240

cgcaggattt taattttggg aaaattaaat aacctggtga aagaatggat tcgagaaatc      300

agtgaaagca agaatctccc acaatctgta attgaaaatg ttggagggaa gatttttaca      360

tttggatctt acagactagg agtccacacg aaaggtgctg atattgatgc gttgtgtgtt      420

gcaccaagac atgttgatcg aagtgacttt ttcacctcat tctatgataa attgaaatta      480

caagaagaag tgaaagattt aagagctgtt gaagaggcat ttgtaccagt tatcaaactc      540

tgttttgatg gaatagagat tgatattttg tttgcaagat tagcactgca gactattcca      600

gaagatttgg acctacgaga tgacagtctg cttaaaaacc tagatataag atgcataaga      660

agccttaatg gttgcagggt aaccgatgaa attttacatc tagtaccaaa cattgacaac      720

ttcaggttaa ctctgagagc catcaaactg tgggccaaac ggcacaacat ctattccaat      780

atattaggtt tcctcggtgg tgtttcctgg gctatgctag tagcaagaac ttgccagctt      840

tatccaaatg caatagcatc aactcttgta cataaatttt tcttggtatt ttctaaatgg      900

gaatggccaa atccagtgct attgaaacag cctgaagaat gcaatcttaa tttgcctgtg      960

tgggacccaa gggtaaaccc cagtgatagg taccatctta tgcctataat tacaccagca     1020

tacccacagc agaactccac gtacaatgtg tccgtttcaa cacggatggt catggttgag     1080

gagtttaaac aaggtcttgc tatcacagat gaaattttgc tgagtaaggc agagtggtcc     1140

aaactttttg aagctccaaa cttctttcag aagtacaagc attatattgt acttctagca     1200

agtgcgccca cggaaaagca gcgtctggaa tgggtgggct tggtggaatc aaaaatccgc     1260

atcctggttg gaagcttgga gaagaatgag tttattacac tggctcatgt gaatccccag     1320

tcatttccag cccccaaaga aagtcctgac agggaagaat ttcgcacaat gtgggtgatt     1380

gggttagtgt ttaaaaaaac tgaaaactct gaaaatctca gtgtcgacct cacctatgat     1440

atccagtctt tcacagacac agtttatagg caagcaataa acagcaaaat gtttgagttg     1500

gatatgaaga ttgcagcaat gcatgtgaag agaaagcaac tccatcagct gctgcctagt     1560

cacgtgcttc agaagaggaa gaagcattca acagaaggag tcaagttaac agctctgaat     1620

gacagcagcc ttgacttgtc tatggacagt gataacagca tgtctgtgcc ttcacccacc     1680

agtgctatga agaccagtcc attgaatagt tctggcagct cccagggcag aaacagtcct     1740

gctccagctg tgaccgcagc atctgtgacc agcatccagg cttctgaggt ttctgtaccg     1800

caagcaaatt ccagtgaaag cccagggggt ccatcgagcg aaagcattcc tcaaactgcc     1860

acacagccag ccattgcccc accaccaaag cctacagtct ccagagttgt ctcctcaaca     1920

cgactggtaa acccatcgcc tagaccttca ggaaacacag caacaaaagt ccctaatcct     1980

atagtaggag tcaagagaac gtccgccccc aataaagaag aagcccctag aaggaccaaa     2040

acagaagagg atgaaacaag tgaagatgct aactgtcttg ctttgagtgg acatgataaa     2100

acagagacaa aggaacaagt tgatctggag acaagtgcgg ttcaatcaga aactgttccg     2160

gcatcggctt ctctgttggc ctctcagaaa acatccagta cagacctttc tgatatccct     2220

gctctccctg caaatcctat tcctgttatc aagaactcaa taaaactgag actgaatcgg     2280

ggatcaggcc ctcgcccact gctcgcaatc caccctactg aagcaaggca caagcaaaaa     2340

attgtggctc ctgtgaagca gacgctgaac tttgatctgc tgaagctcgc tggcgacgtg     2400

gagtcgaacc ctggccctag caagatctac atcgacgaga gaagcgacgc cgagatcgtg     2460

tgcgccgcca tcaagaacat cggcatcgag ggcgccaccg ccgcccagct gaccagacag     2520

ctgaacatgg agaagagaga ggtgaacaag gccctgtacg acctgcagag aagcgccatg     2580

gtgtacagca gcgacgacat cccccccaga tggttcatga ccaccgaggc cgacaagccc     2640

gacgccgacg ccatggccga cgtgatcatc gacgacgtga gcagagagaa gagcatgaga     2700

gaggaccaca agagcttcga cgacgtgatc cccgccaaga agatcatcga ctggaaggac     2760

gccgacccca atacagtctc ctcttttcaa gtggactgtt ttttgtggca tgttcgaaag     2820

cgggttgctg accaagagct gggggatgcc ccgtttctag accggctacg gagagaccaa     2880

aagagcttgc gtgggagagg cagtaccctg ggcctcgaca tcgagaccgc tacacgcgcc     2940

ggcaagcaga tcgtggaacg catcttaaaa gaggagtccg gaggcggggg aagtggaggg     3000

ggcggcagta ggatggctca gttggaggct aaggtagagg aactattgtc caaaaattgg     3060

aatctcgaga acgaagtagc tcgcctcaag aaactggtcg gcgagcgcgg atcaggcccg     3120

cgacccctcc ttgccatcca cccaaccgag gcacggcaca agcagaaaat agtggcaccc     3180

gttaagcaga ctctcaactt tgatctcctg aagcttgccg gcgacgtaga gtccaacccc     3240

ggccccgcca gcctggacaa cctggtggcc agataccagc ggtgcttcaa cgaccagagc     3300

ctgaagaaca gcaccatcga gctggaaatc cggttccagc agatcaactt cctgctgttc     3360

aagaccgtgt acgaggccct ggtcgcccag gaaatcccca gcaccatcag ccacagcatc     3420

cggtgcatca agaaggtgca ccacgagaac cactgccggg agaagatcct gcccagcgag     3480

aacctgtact tcaagaaaca gcccctgatg ttcttcaagt tcagcgagcc cgccagcctg     3540

ggctgtaaag tgtccctggc catcgagcag cccatccgga agttcatcct ggacagcagc     3600

gtgctggtcc ggctgaagaa ccggaccacc ttccgggtgt ccgagctgtg gaagatcgag     3660

ctgaccatcg tgaagcagct gatgggcagc gaggtgtcag ccaagctggc cgccttcaag     3720

accctgctgt tcgacacccc cgagcagcag accaccaaga acatgatgac cctgatcaac     3780

cccgacgacg agtacctgta cgagatcgag atcgagtaca ccggcaagcc tgagagcctg     3840

acagccgccg acgtgatcaa gatcaagaac accgtgctga cactgatcag ccccaaccac     3900

ctgatgctga ccgcctacca ccaggccatc gagtttatcg ccagccacat cctgagcagc     3960

gagatcctgc tggcccggat caagagcggc aagtggggcc tgaagagact gctgccccag     4020

gtcaagtcca tgaccaaggc cgactacatg aagttctacc cccccgtggg ctactacgtg     4080

accgacaagg ccgacggcat ccggggcatt gccgtgatcc aggacaccca gatctacgtg     4140

gtggccgacc agctgtacag cctgggcacc accggcatcg agcccctgaa gcccaccatc     4200

ctggacggcg agttcatgcc cgagaagaaa gagttctacg gctttgacgt gatcatgtac     4260

gagggcaacc tgctgaccca gcagggcttc gagacacgga tcgagagcct gagcaagggc     4320

atcaaggtgc tgcaggcctt caacatcaag gccgagatga agcccttcat cagcctgacc     4380

tccgccgacc ccaacgtgct gctgaagaat ttcgagagca tcttcaagaa gaaaacccgg     4440

ccctacagca tcgacggcat catcctggtg gagcccggca acagctacct gaacaccaac     4500

accttcaagt ggaagcccac ctgggacaac accctggact ttctggtccg gaagtgcccc     4560

gagtccctga acgtgcccga gtacgccccc aagaagggct tcagcctgca tctgctgttc     4620

gtgggcatca gcggcgagct gtttaagaag ctggccctga actggtgccc cggctacacc     4680

aagctgttcc ccgtgaccca gcggaaccag aactacttcc ccgtgcagtt ccagcccagc     4740

gacttccccc tggccttcct gtactaccac cccgacacca gcagcttcag caacatcgat     4800

ggcaaggtgc tggaaatgcg gtgcctgaag cgggagatca actacgtgcg ctgggagatc     4860

gtgaagatcc gggaggaccg gcagcaggat ctgaaaaccg gcggctactt cggcaacgac     4920

ttcaagaccg ccgagctgac ctggctgaac tacatggacc ccttcagctt cgaggaactg     4980

gccaagggac ccagcggcat gtacttcgct ggcgccaaga ccggcatcta cagagcccag     5040

accgccctga tcagcttcat caagcaggaa atcatccaga agatcagcca ccagagctgg     5100

gtgatcgacc tgggcatcgg caagggccag gacctgggca gatacctgga cgccggcgtg     5160

agacacctgg tcggcatcga taaggaccag acagccctgg ccgagctggt gtaccggaag     5220

ttctcccacg ccaccaccag acagcacaag cacgccacca acatctacgt gctgcaccag     5280

gatctggccg agcctgccaa agaaatcagc gagaaagtgc accagatcta tggcttcccc     5340

aaagagggcg ccagcagcat cgtgtccaac ctgttcatcc actacctgat gaagaacacc     5400

cagcaggtcg agaacctggc tgtgctgtgc cacaagctgc tgcagcctgg cggcatggtc     5460

tggttcacca ccatgctggg cgaacaggtg ctggaactgc tgcacgagaa ccggatcgaa     5520

ctgaacgaag tgtgggaggc ccgggagaac gaggtggtca agttcgccat caagcggctg     5580

ttcaaagagg acatcctgca ggaaaccggc caggaaatcg gcgtcctgct gcccttcagc     5640

aacggcgact tctacaatga gtacctggtc aacaccgcct ttctgatcaa gattttcaag     5700

caccatggct ttagcctcgt gcagaagcag agcttcaagg actggatccc cgagttccag     5760

aacttcagca agagcctgta caagatcctg accgaggccg acaagacctg gaccagcctg     5820

ttcggcttca tctgcctgcg gaagaacgga ggcgggggaa gtggaggggg cggcagtcag     5880

gacctgcacg ccatccagct gcagctcgaa gaggaaatgt tcaacggcgg catcagaaga     5940

ttcgaggccg accagcagag acagatcgcc tctggcaacg agagcgacac cgcctggaat     6000

agaaggctgc tgtctgagct gatcgcccct atggccgaag gcatccaggc ctacaaagag     6060

gaatacgagg gcaagagagg cagagcccct agagccctgg ccttcatcaa ctgtgtgggc     6120

aatgaggtgg ccgcctacat caccatgaag atcgtgatgg acatgctgaa caccgacgtg     6180

accctgcagg ccattgccat gaacgtggcc gacagaatcg aggaccaggt ccgattcagc     6240

aagctggaag gacacgccgc caagtacttc gagaaagtga agaagtccct gaaggccagc     6300

aagaccaaga gctacagaca cgcccacaac gtggccgtgg tggccgaaaa atctgtggcc     6360

gatagggacg ccgacttctc tagatgggag gcctggccta aggacaccct gctgcagatc     6420

ggcatgaccc tgctggaaat cctggaaaac agcgtgttct tcaacggcca gcccgtgttc     6480

ctgagaaccc tgaggacaaa tggcggcaag cacggcgtgt actacctgca gacatctgag     6540

cacgtgggcg agtggatcac cgccttcaaa gaacatgtgg cccagctgag ccctgcctat     6600

gccccttgtg tgatccctcc tagaccctgg gtgtcccctt tcaatggcgg ctttcacacc     6660

gagaaggtgg ccagcagaat cagactggtc aagggcaacc gggaacacgt gcggaagctg     6720

accaagaaac agatgcccgc cgtgtacaag gccgtgaatg ctctgcaggc caccaagtgg     6780

caggtcaaca aagaggtgct gcaggtcgtc gaggacgtga tcagactgga tctgggctac     6840

ggcgtgccaa gctttaagcc cctgatcgac agagagaaca agcccgccaa ccctgtgccc     6900

ctggaatttc agcacctgag aggccgcgag ctgaaagaga tgctgacacc tgaacagtgg     6960

caggccttta tcaattggaa gggcgagtgc accaagctgt acaccgccga gacaaagagg     7020

ggctctaagt ctgccgccac agtgcgaatg gtcggacagg ccagaaagta cagccagttc     7080

gacgccatct acttcgtgta cgccctggac agccggtcta gagtgtatgc ccagagcagc     7140

acactgagcc cccagtctaa cgatctggga aaggccctgc tgagattcac cgagggccag     7200

agactggatt ctgccgaagc cctgaagtgg ttcctggtca acggcgccaa caactggggc     7260

tgggacaaga aaaccttcga tgtgcggacc gccaacgtgc tggatagcga gttccaggac     7320

atgtgcagag atatcgccgc cgaccctctg acctttaccc agtgggtcaa cgccgatagc     7380

ccctatggat tcctggcctg gtgcttcgag tacgccagat acctggacgc cctggatgag     7440

ggaacccagg atcagttcat gacccatctg cccgtgcacc aggatggctc ttgttctggc     7500

atccagcact acagcgccat gctgagcgat gccgtgggag ccaaagccgt gaacctgaag     7560

cctagcgaca gcccccagga tatctatggc gctgtggccc aggtggtcat ccagaaaaac     7620

tacgcctaca tgaacgccga ggacgccgag acattcacaa gcggaagcgt gacactgaca     7680

ggcgccgagc tgagatctat ggcctctgcc tgggacatga tcggcatcac acggggcctg     7740

accaaaaagc ctgtgatgac actgccctac ggcagcacca gactgacctg tagagaaagc     7800

gtgatcgact acatcgtgga cctggaagag aaagaggccc agagagccat tgccgagggc     7860

agaacagcca atcctgtgca ccccttcgac aacgaccgga aggatagcct gacacctagc     7920

gccgcctaca actacatgac cgccctgatc tggcccagca tctctgaagt ggtcaaggcc     7980

cctatcgtgg ccatgaagat gatcagacag ctggccagat tcgccgccaa gagaaatgag     8040

ggcctggaat accctctgcc caccggcttt atcctgcagc agaaaatcat ggccaccgac     8100

atgctgcggg tgtccacatg tctgatgggc gagatcaaga tgagcctgca gatcgagaca     8160

gacgtggtgg acgagacagc catgatggga gccgccgctc ctaattttgt gcacggacac     8220

gatgccagcc acctgatcct gaccgtgtgc gatctggtgg acaagggcat cactagcgtg     8280

gccgtgatcc acgatagctt tggaacacac gccggcagaa ccgccgacct gagagattct     8340

ctgcgggaag agatggtcaa gatgtaccag aaccacaacg ccctgcagaa cctgctggac     8400

gtgcacgaag aaagatggct ggtggacacc ggcatccagg tgccagaaca gggagagttc     8460

gacctgaacg agatcctggt gtccgactac tgcttcgcct ga                        8502


<210>  20
<211>  2833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pC3P3-G3a plasmid

<400>  20

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn Pro Phe Pro Val Thr Thr Gln Gly Ser Gln 
            20                  25                  30          


Gln Thr Gln Pro Pro Gln Arg His Tyr Gly Ile Thr Ser Pro Ile Ser 
        35                  40                  45              


Leu Ala Ala Pro Lys Glu Thr Asp Cys Leu Leu Thr Gln Lys Leu Ile 
    50                  55                  60                  


Glu Thr Leu Lys Pro Phe Gly Val Phe Glu Glu Glu Glu Glu Leu Gln 
65                  70                  75                  80  


Arg Arg Ile Leu Ile Leu Gly Lys Leu Asn Asn Leu Val Lys Glu Trp 
                85                  90                  95      


Ile Arg Glu Ile Ser Glu Ser Lys Asn Leu Pro Gln Ser Val Ile Glu 
            100                 105                 110         


Asn Val Gly Gly Lys Ile Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val 
        115                 120                 125             


His Thr Lys Gly Ala Asp Ile Asp Ala Leu Cys Val Ala Pro Arg His 
    130                 135                 140                 


Val Asp Arg Ser Asp Phe Phe Thr Ser Phe Tyr Asp Lys Leu Lys Leu 
145                 150                 155                 160 


Gln Glu Glu Val Lys Asp Leu Arg Ala Val Glu Glu Ala Phe Val Pro 
                165                 170                 175     


Val Ile Lys Leu Cys Phe Asp Gly Ile Glu Ile Asp Ile Leu Phe Ala 
            180                 185                 190         


Arg Leu Ala Leu Gln Thr Ile Pro Glu Asp Leu Asp Leu Arg Asp Asp 
        195                 200                 205             


Ser Leu Leu Lys Asn Leu Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly 
    210                 215                 220                 


Cys Arg Val Thr Asp Glu Ile Leu His Leu Val Pro Asn Ile Asp Asn 
225                 230                 235                 240 


Phe Arg Leu Thr Leu Arg Ala Ile Lys Leu Trp Ala Lys Arg His Asn 
                245                 250                 255     


Ile Tyr Ser Asn Ile Leu Gly Phe Leu Gly Gly Val Ser Trp Ala Met 
            260                 265                 270         


Leu Val Ala Arg Thr Cys Gln Leu Tyr Pro Asn Ala Ile Ala Ser Thr 
        275                 280                 285             


Leu Val His Lys Phe Phe Leu Val Phe Ser Lys Trp Glu Trp Pro Asn 
    290                 295                 300                 


Pro Val Leu Leu Lys Gln Pro Glu Glu Cys Asn Leu Asn Leu Pro Val 
305                 310                 315                 320 


Trp Asp Pro Arg Val Asn Pro Ser Asp Arg Tyr His Leu Met Pro Ile 
                325                 330                 335     


Ile Thr Pro Ala Tyr Pro Gln Gln Asn Ser Thr Tyr Asn Val Ser Val 
            340                 345                 350         


Ser Thr Arg Met Val Met Val Glu Glu Phe Lys Gln Gly Leu Ala Ile 
        355                 360                 365             


Thr Asp Glu Ile Leu Leu Ser Lys Ala Glu Trp Ser Lys Leu Phe Glu 
    370                 375                 380                 


Ala Pro Asn Phe Phe Gln Lys Tyr Lys His Tyr Ile Val Leu Leu Ala 
385                 390                 395                 400 


Ser Ala Pro Thr Glu Lys Gln Arg Leu Glu Trp Val Gly Leu Val Glu 
                405                 410                 415     


Ser Lys Ile Arg Ile Leu Val Gly Ser Leu Glu Lys Asn Glu Phe Ile 
            420                 425                 430         


Thr Leu Ala His Val Asn Pro Gln Ser Phe Pro Ala Pro Lys Glu Ser 
        435                 440                 445             


Pro Asp Arg Glu Glu Phe Arg Thr Met Trp Val Ile Gly Leu Val Phe 
    450                 455                 460                 


Lys Lys Thr Glu Asn Ser Glu Asn Leu Ser Val Asp Leu Thr Tyr Asp 
465                 470                 475                 480 


Ile Gln Ser Phe Thr Asp Thr Val Tyr Arg Gln Ala Ile Asn Ser Lys 
                485                 490                 495     


Met Phe Glu Leu Asp Met Lys Ile Ala Ala Met His Val Lys Arg Lys 
            500                 505                 510         


Gln Leu His Gln Leu Leu Pro Ser His Val Leu Gln Lys Arg Lys Lys 
        515                 520                 525             


His Ser Thr Glu Gly Val Lys Leu Thr Ala Leu Asn Asp Ser Ser Leu 
    530                 535                 540                 


Asp Leu Ser Met Asp Ser Asp Asn Ser Met Ser Val Pro Ser Pro Thr 
545                 550                 555                 560 


Ser Ala Met Lys Thr Ser Pro Leu Asn Ser Ser Gly Ser Ser Gln Gly 
                565                 570                 575     


Arg Asn Ser Pro Ala Pro Ala Val Thr Ala Ala Ser Val Thr Ser Ile 
            580                 585                 590         


Gln Ala Ser Glu Val Ser Val Pro Gln Ala Asn Ser Ser Glu Ser Pro 
        595                 600                 605             


Gly Gly Pro Ser Ser Glu Ser Ile Pro Gln Thr Ala Thr Gln Pro Ala 
    610                 615                 620                 


Ile Ala Pro Pro Pro Lys Pro Thr Val Ser Arg Val Val Ser Ser Thr 
625                 630                 635                 640 


Arg Leu Val Asn Pro Ser Pro Arg Pro Ser Gly Asn Thr Ala Thr Lys 
                645                 650                 655     


Val Pro Asn Pro Ile Val Gly Val Lys Arg Thr Ser Ala Pro Asn Lys 
            660                 665                 670         


Glu Glu Ala Pro Arg Arg Thr Lys Thr Glu Glu Asp Glu Thr Ser Glu 
        675                 680                 685             


Asp Ala Asn Cys Leu Ala Leu Ser Gly His Asp Lys Thr Glu Thr Lys 
    690                 695                 700                 


Glu Gln Val Asp Leu Glu Thr Ser Ala Val Gln Ser Glu Thr Val Pro 
705                 710                 715                 720 


Ala Ser Ala Ser Leu Leu Ala Ser Gln Lys Thr Ser Ser Thr Asp Leu 
                725                 730                 735     


Ser Asp Ile Pro Ala Leu Pro Ala Asn Pro Ile Pro Val Ile Lys Asn 
            740                 745                 750         


Ser Ile Lys Leu Arg Leu Asn Arg Gly Ser Gly Pro Arg Pro Leu Leu 
        755                 760                 765             


Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro 
    770                 775                 780                 


Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
785                 790                 795                 800 


Glu Ser Asn Pro Gly Pro Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp 
                805                 810                 815     


Ala Glu Ile Val Cys Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala 
            820                 825                 830         


Thr Ala Ala Gln Leu Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val 
        835                 840                 845             


Asn Lys Ala Leu Tyr Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser 
    850                 855                 860                 


Asp Asp Ile Pro Pro Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro 
865                 870                 875                 880 


Asp Ala Asp Ala Met Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu 
                885                 890                 895     


Lys Ser Met Arg Glu Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala 
            900                 905                 910         


Lys Lys Ile Ile Asp Trp Lys Asp Ala Asp Pro Asn Thr Val Ser Ser 
        915                 920                 925             


Phe Gln Val Asp Cys Phe Leu Trp His Val Arg Lys Arg Val Ala Asp 
    930                 935                 940                 


Gln Glu Leu Gly Asp Ala Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln 
945                 950                 955                 960 


Lys Ser Leu Arg Gly Arg Gly Ser Thr Leu Gly Leu Asp Ile Glu Thr 
                965                 970                 975     


Ala Thr Arg Ala Gly Lys Gln Ile Val Glu Arg Ile Leu Lys Glu Glu 
            980                 985                 990         


Ser Gly Gly Gly Gly Ser Gly Gly  Gly Gly Ser Arg Met  Ala Gln Leu 
        995                 1000                 1005             


Glu Ala  Lys Val Glu Glu Leu  Leu Ser Lys Asn Trp  Asn Leu Glu 
    1010                 1015                 1020             


Asn Glu  Val Ala Arg Leu Lys  Lys Leu Val Gly Glu  Arg Gly Ser 
    1025                 1030                 1035             


Gly Pro  Arg Pro Leu Leu Ala  Ile His Pro Thr Glu  Ala Arg His 
    1040                 1045                 1050             


Lys Gln  Lys Ile Val Ala Pro  Val Lys Gln Thr Leu  Asn Phe Asp 
    1055                 1060                 1065             


Leu Leu  Lys Leu Ala Gly Asp  Val Glu Ser Asn Pro  Gly Pro Ala 
    1070                 1075                 1080             


Ser Leu  Asp Asn Leu Val Ala  Arg Tyr Gln Arg Cys  Phe Asn Asp 
    1085                 1090                 1095             


Gln Ser  Leu Lys Asn Ser Thr  Ile Glu Leu Glu Ile  Arg Phe Gln 
    1100                 1105                 1110             


Gln Ile  Asn Phe Leu Leu Phe  Lys Thr Val Tyr Glu  Ala Leu Val 
    1115                 1120                 1125             


Ala Gln  Glu Ile Pro Ser Thr  Ile Ser His Ser Ile  Arg Cys Ile 
    1130                 1135                 1140             


Lys Lys  Val His His Glu Asn  His Cys Arg Glu Lys  Ile Leu Pro 
    1145                 1150                 1155             


Ser Glu  Asn Leu Tyr Phe Lys  Lys Gln Pro Leu Met  Phe Phe Lys 
    1160                 1165                 1170             


Phe Ser  Glu Pro Ala Ser Leu  Gly Cys Lys Val Ser  Leu Ala Ile 
    1175                 1180                 1185             


Glu Gln  Pro Ile Arg Lys Phe  Ile Leu Asp Ser Ser  Val Leu Val 
    1190                 1195                 1200             


Arg Leu  Lys Asn Arg Thr Thr  Phe Arg Val Ser Glu  Leu Trp Lys 
    1205                 1210                 1215             


Ile Glu  Leu Thr Ile Val Lys  Gln Leu Met Gly Ser  Glu Val Ser 
    1220                 1225                 1230             


Ala Lys  Leu Ala Ala Phe Lys  Thr Leu Leu Phe Asp  Thr Pro Glu 
    1235                 1240                 1245             


Gln Gln  Thr Thr Lys Asn Met  Met Thr Leu Ile Asn  Pro Asp Asp 
    1250                 1255                 1260             


Glu Tyr  Leu Tyr Glu Ile Glu  Ile Glu Tyr Thr Gly  Lys Pro Glu 
    1265                 1270                 1275             


Ser Leu  Thr Ala Ala Asp Val  Ile Lys Ile Lys Asn  Thr Val Leu 
    1280                 1285                 1290             


Thr Leu  Ile Ser Pro Asn His  Leu Met Leu Thr Ala  Tyr His Gln 
    1295                 1300                 1305             


Ala Ile  Glu Phe Ile Ala Ser  His Ile Leu Ser Ser  Glu Ile Leu 
    1310                 1315                 1320             


Leu Ala  Arg Ile Lys Ser Gly  Lys Trp Gly Leu Lys  Arg Leu Leu 
    1325                 1330                 1335             


Pro Gln  Val Lys Ser Met Thr  Lys Ala Asp Tyr Met  Lys Phe Tyr 
    1340                 1345                 1350             


Pro Pro  Val Gly Tyr Tyr Val  Thr Asp Lys Ala Asp  Gly Ile Arg 
    1355                 1360                 1365             


Gly Ile  Ala Val Ile Gln Asp  Thr Gln Ile Tyr Val  Val Ala Asp 
    1370                 1375                 1380             


Gln Leu  Tyr Ser Leu Gly Thr  Thr Gly Ile Glu Pro  Leu Lys Pro 
    1385                 1390                 1395             


Thr Ile  Leu Asp Gly Glu Phe  Met Pro Glu Lys Lys  Glu Phe Tyr 
    1400                 1405                 1410             


Gly Phe  Asp Val Ile Met Tyr  Glu Gly Asn Leu Leu  Thr Gln Gln 
    1415                 1420                 1425             


Gly Phe  Glu Thr Arg Ile Glu  Ser Leu Ser Lys Gly  Ile Lys Val 
    1430                 1435                 1440             


Leu Gln  Ala Phe Asn Ile Lys  Ala Glu Met Lys Pro  Phe Ile Ser 
    1445                 1450                 1455             


Leu Thr  Ser Ala Asp Pro Asn  Val Leu Leu Lys Asn  Phe Glu Ser 
    1460                 1465                 1470             


Ile Phe  Lys Lys Lys Thr Arg  Pro Tyr Ser Ile Asp  Gly Ile Ile 
    1475                 1480                 1485             


Leu Val  Glu Pro Gly Asn Ser  Tyr Leu Asn Thr Asn  Thr Phe Lys 
    1490                 1495                 1500             


Trp Lys  Pro Thr Trp Asp Asn  Thr Leu Asp Phe Leu  Val Arg Lys 
    1505                 1510                 1515             


Cys Pro  Glu Ser Leu Asn Val  Pro Glu Tyr Ala Pro  Lys Lys Gly 
    1520                 1525                 1530             


Phe Ser  Leu His Leu Leu Phe  Val Gly Ile Ser Gly  Glu Leu Phe 
    1535                 1540                 1545             


Lys Lys  Leu Ala Leu Asn Trp  Cys Pro Gly Tyr Thr  Lys Leu Phe 
    1550                 1555                 1560             


Pro Val  Thr Gln Arg Asn Gln  Asn Tyr Phe Pro Val  Gln Phe Gln 
    1565                 1570                 1575             


Pro Ser  Asp Phe Pro Leu Ala  Phe Leu Tyr Tyr His  Pro Asp Thr 
    1580                 1585                 1590             


Ser Ser  Phe Ser Asn Ile Asp  Gly Lys Val Leu Glu  Met Arg Cys 
    1595                 1600                 1605             


Leu Lys  Arg Glu Ile Asn Tyr  Val Arg Trp Glu Ile  Val Lys Ile 
    1610                 1615                 1620             


Arg Glu  Asp Arg Gln Gln Asp  Leu Lys Thr Gly Gly  Tyr Phe Gly 
    1625                 1630                 1635             


Asn Asp  Phe Lys Thr Ala Glu  Leu Thr Trp Leu Asn  Tyr Met Asp 
    1640                 1645                 1650             


Pro Phe  Ser Phe Glu Glu Leu  Ala Lys Gly Pro Ser  Gly Met Tyr 
    1655                 1660                 1665             


Phe Ala  Gly Ala Lys Thr Gly  Ile Tyr Arg Ala Gln  Thr Ala Leu 
    1670                 1675                 1680             


Ile Ser  Phe Ile Lys Gln Glu  Ile Ile Gln Lys Ile  Ser His Gln 
    1685                 1690                 1695             


Ser Trp  Val Ile Asp Leu Gly  Ile Gly Lys Gly Gln  Asp Leu Gly 
    1700                 1705                 1710             


Arg Tyr  Leu Asp Ala Gly Val  Arg His Leu Val Gly  Ile Asp Lys 
    1715                 1720                 1725             


Asp Gln  Thr Ala Leu Ala Glu  Leu Val Tyr Arg Lys  Phe Ser His 
    1730                 1735                 1740             


Ala Thr  Thr Arg Gln His Lys  His Ala Thr Asn Ile  Tyr Val Leu 
    1745                 1750                 1755             


His Gln  Asp Leu Ala Glu Pro  Ala Lys Glu Ile Ser  Glu Lys Val 
    1760                 1765                 1770             


His Gln  Ile Tyr Gly Phe Pro  Lys Glu Gly Ala Ser  Ser Ile Val 
    1775                 1780                 1785             


Ser Asn  Leu Phe Ile His Tyr  Leu Met Lys Asn Thr  Gln Gln Val 
    1790                 1795                 1800             


Glu Asn  Leu Ala Val Leu Cys  His Lys Leu Leu Gln  Pro Gly Gly 
    1805                 1810                 1815             


Met Val  Trp Phe Thr Thr Met  Leu Gly Glu Gln Val  Leu Glu Leu 
    1820                 1825                 1830             


Leu His  Glu Asn Arg Ile Glu  Leu Asn Glu Val Trp  Glu Ala Arg 
    1835                 1840                 1845             


Glu Asn  Glu Val Val Lys Phe  Ala Ile Lys Arg Leu  Phe Lys Glu 
    1850                 1855                 1860             


Asp Ile  Leu Gln Glu Thr Gly  Gln Glu Ile Gly Val  Leu Leu Pro 
    1865                 1870                 1875             


Phe Ser  Asn Gly Asp Phe Tyr  Asn Glu Tyr Leu Val  Asn Thr Ala 
    1880                 1885                 1890             


Phe Leu  Ile Lys Ile Phe Lys  His His Gly Phe Ser  Leu Val Gln 
    1895                 1900                 1905             


Lys Gln  Ser Phe Lys Asp Trp  Ile Pro Glu Phe Gln  Asn Phe Ser 
    1910                 1915                 1920             


Lys Ser  Leu Tyr Lys Ile Leu  Thr Glu Ala Asp Lys  Thr Trp Thr 
    1925                 1930                 1935             


Ser Leu  Phe Gly Phe Ile Cys  Leu Arg Lys Asn Gly  Gly Gly Gly 
    1940                 1945                 1950             


Ser Gly  Gly Gly Gly Ser Gln  Asp Leu His Ala Ile  Gln Leu Gln 
    1955                 1960                 1965             


Leu Glu  Glu Glu Met Phe Asn  Gly Gly Ile Arg Arg  Phe Glu Ala 
    1970                 1975                 1980             


Asp Gln  Gln Arg Gln Ile Ala  Ser Gly Asn Glu Ser  Asp Thr Ala 
    1985                 1990                 1995             


Trp Asn  Arg Arg Leu Leu Ser  Glu Leu Ile Ala Pro  Met Ala Glu 
    2000                 2005                 2010             


Gly Ile  Gln Ala Tyr Lys Glu  Glu Tyr Glu Gly Lys  Arg Gly Arg 
    2015                 2020                 2025             


Ala Pro  Arg Ala Leu Ala Phe  Ile Asn Cys Val Gly  Asn Glu Val 
    2030                 2035                 2040             


Ala Ala  Tyr Ile Thr Met Lys  Ile Val Met Asp Met  Leu Asn Thr 
    2045                 2050                 2055             


Asp Val  Thr Leu Gln Ala Ile  Ala Met Asn Val Ala  Asp Arg Ile 
    2060                 2065                 2070             


Glu Asp  Gln Val Arg Phe Ser  Lys Leu Glu Gly His  Ala Ala Lys 
    2075                 2080                 2085             


Tyr Phe  Glu Lys Val Lys Lys  Ser Leu Lys Ala Ser  Lys Thr Lys 
    2090                 2095                 2100             


Ser Tyr  Arg His Ala His Asn  Val Ala Val Val Ala  Glu Lys Ser 
    2105                 2110                 2115             


Val Ala  Asp Arg Asp Ala Asp  Phe Ser Arg Trp Glu  Ala Trp Pro 
    2120                 2125                 2130             


Lys Asp  Thr Leu Leu Gln Ile  Gly Met Thr Leu Leu  Glu Ile Leu 
    2135                 2140                 2145             


Glu Asn  Ser Val Phe Phe Asn  Gly Gln Pro Val Phe  Leu Arg Thr 
    2150                 2155                 2160             


Leu Arg  Thr Asn Gly Gly Lys  His Gly Val Tyr Tyr  Leu Gln Thr 
    2165                 2170                 2175             


Ser Glu  His Val Gly Glu Trp  Ile Thr Ala Phe Lys  Glu His Val 
    2180                 2185                 2190             


Ala Gln  Leu Ser Pro Ala Tyr  Ala Pro Cys Val Ile  Pro Pro Arg 
    2195                 2200                 2205             


Pro Trp  Val Ser Pro Phe Asn  Gly Gly Phe His Thr  Glu Lys Val 
    2210                 2215                 2220             


Ala Ser  Arg Ile Arg Leu Val  Lys Gly Asn Arg Glu  His Val Arg 
    2225                 2230                 2235             


Lys Leu  Thr Lys Lys Gln Met  Pro Ala Val Tyr Lys  Ala Val Asn 
    2240                 2245                 2250             


Ala Leu  Gln Ala Thr Lys Trp  Gln Val Asn Lys Glu  Val Leu Gln 
    2255                 2260                 2265             


Val Val  Glu Asp Val Ile Arg  Leu Asp Leu Gly Tyr  Gly Val Pro 
    2270                 2275                 2280             


Ser Phe  Lys Pro Leu Ile Asp  Arg Glu Asn Lys Pro  Ala Asn Pro 
    2285                 2290                 2295             


Val Pro  Leu Glu Phe Gln His  Leu Arg Gly Arg Glu  Leu Lys Glu 
    2300                 2305                 2310             


Met Leu  Thr Pro Glu Gln Trp  Gln Ala Phe Ile Asn  Trp Lys Gly 
    2315                 2320                 2325             


Glu Cys  Thr Lys Leu Tyr Thr  Ala Glu Thr Lys Arg  Gly Ser Lys 
    2330                 2335                 2340             


Ser Ala  Ala Thr Val Arg Met  Val Gly Gln Ala Arg  Lys Tyr Ser 
    2345                 2350                 2355             


Gln Phe  Asp Ala Ile Tyr Phe  Val Tyr Ala Leu Asp  Ser Arg Ser 
    2360                 2365                 2370             


Arg Val  Tyr Ala Gln Ser Ser  Thr Leu Ser Pro Gln  Ser Asn Asp 
    2375                 2380                 2385             


Leu Gly  Lys Ala Leu Leu Arg  Phe Thr Glu Gly Gln  Arg Leu Asp 
    2390                 2395                 2400             


Ser Ala  Glu Ala Leu Lys Trp  Phe Leu Val Asn Gly  Ala Asn Asn 
    2405                 2410                 2415             


Trp Gly  Trp Asp Lys Lys Thr  Phe Asp Val Arg Thr  Ala Asn Val 
    2420                 2425                 2430             


Leu Asp  Ser Glu Phe Gln Asp  Met Cys Arg Asp Ile  Ala Ala Asp 
    2435                 2440                 2445             


Pro Leu  Thr Phe Thr Gln Trp  Val Asn Ala Asp Ser  Pro Tyr Gly 
    2450                 2455                 2460             


Phe Leu  Ala Trp Cys Phe Glu  Tyr Ala Arg Tyr Leu  Asp Ala Leu 
    2465                 2470                 2475             


Asp Glu  Gly Thr Gln Asp Gln  Phe Met Thr His Leu  Pro Val His 
    2480                 2485                 2490             


Gln Asp  Gly Ser Cys Ser Gly  Ile Gln His Tyr Ser  Ala Met Leu 
    2495                 2500                 2505             


Ser Asp  Ala Val Gly Ala Lys  Ala Val Asn Leu Lys  Pro Ser Asp 
    2510                 2515                 2520             


Ser Pro  Gln Asp Ile Tyr Gly  Ala Val Ala Gln Val  Val Ile Gln 
    2525                 2530                 2535             


Lys Asn  Tyr Ala Tyr Met Asn  Ala Glu Asp Ala Glu  Thr Phe Thr 
    2540                 2545                 2550             


Ser Gly  Ser Val Thr Leu Thr  Gly Ala Glu Leu Arg  Ser Met Ala 
    2555                 2560                 2565             


Ser Ala  Trp Asp Met Ile Gly  Ile Thr Arg Gly Leu  Thr Lys Lys 
    2570                 2575                 2580             


Pro Val  Met Thr Leu Pro Tyr  Gly Ser Thr Arg Leu  Thr Cys Arg 
    2585                 2590                 2595             


Glu Ser  Val Ile Asp Tyr Ile  Val Asp Leu Glu Glu  Lys Glu Ala 
    2600                 2605                 2610             


Gln Arg  Ala Ile Ala Glu Gly  Arg Thr Ala Asn Pro  Val His Pro 
    2615                 2620                 2625             


Phe Asp  Asn Asp Arg Lys Asp  Ser Leu Thr Pro Ser  Ala Ala Tyr 
    2630                 2635                 2640             


Asn Tyr  Met Thr Ala Leu Ile  Trp Pro Ser Ile Ser  Glu Val Val 
    2645                 2650                 2655             


Lys Ala  Pro Ile Val Ala Met  Lys Met Ile Arg Gln  Leu Ala Arg 
    2660                 2665                 2670             


Phe Ala  Ala Lys Arg Asn Glu  Gly Leu Glu Tyr Pro  Leu Pro Thr 
    2675                 2680                 2685             


Gly Phe  Ile Leu Gln Gln Lys  Ile Met Ala Thr Asp  Met Leu Arg 
    2690                 2695                 2700             


Val Ser  Thr Cys Leu Met Gly  Glu Ile Lys Met Ser  Leu Gln Ile 
    2705                 2710                 2715             


Glu Thr  Asp Val Val Asp Glu  Thr Ala Met Met Gly  Ala Ala Ala 
    2720                 2725                 2730             


Pro Asn  Phe Val His Gly His  Asp Ala Ser His Leu  Ile Leu Thr 
    2735                 2740                 2745             


Val Cys  Asp Leu Val Asp Lys  Gly Ile Thr Ser Val  Ala Val Ile 
    2750                 2755                 2760             


His Asp  Ser Phe Gly Thr His  Ala Gly Arg Thr Ala  Asp Leu Arg 
    2765                 2770                 2775             


Asp Ser  Leu Arg Glu Glu Met  Val Lys Met Tyr Gln  Asn His Asn 
    2780                 2785                 2790             


Ala Leu  Gln Asn Leu Leu Asp  Val His Glu Glu Arg  Trp Leu Val 
    2795                 2800                 2805             


Asp Thr  Gly Ile Gln Val Pro  Glu Gln Gly Glu Phe  Asp Leu Asn 
    2810                 2815                 2820             


Glu Ile  Leu Val Ser Asp Tyr  Cys Phe Ala 
    2825                 2830             


<210>  21
<211>  8394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pC3P3-G3b plasmid

<400>  21
atggatgctc agaccagacg cagagaacgg cgggcagaga agcaggcaca gtggaaggcc       60

gctaatccgt ttccagttac aacgcaggga tcacaacaaa cgcagccacc acagaggcac      120

tatggcatta cctctcctat cagcttagcg gcccccaagg agactgactg cctactcaca      180

cagaagctca tcgagacgct gaagcccttt ggggtttttg aagaagaaga ggaactgcag      240

cgcaggattt taattttggg aaaattaaat aacctggtga aagaatggat tcgagaaatc      300

agtgaaagca agaatctccc acaatctgta attgaaaatg ttggagggaa gatttttaca      360

tttggatctt acagactagg agtccacacg aaaggtgctg atattgatgc gttgtgtgtt      420

gcaccaagac atgttgatcg aagtgacttt ttcacctcat tctatgataa attgaaatta      480

caagaagaag tgaaagattt aagagctgtt gaagaggcat ttgtaccagt tatcaaactc      540

tgttttgatg gaatagagat tgatattttg tttgcaagat tagcactgca gactattcca      600

gaagatttgg acctacgaga tgacagtctg cttaaaaacc tagatataag atgcataaga      660

agccttaatg gttgcagggt aaccgatgaa attttacatc tagtaccaaa cattgacaac      720

ttcaggttaa ctctgagagc catcaaactg tgggccaaac ggcacaacat ctattccaat      780

atattaggtt tcctcggtgg tgtttcctgg gctatgctag tagcaagaac ttgccagctt      840

tatccaaatg caatagcatc aactcttgta cataaatttt tcttggtatt ttctaaatgg      900

gaatggccaa atccagtgct attgaaacag cctgaagaat gcaatcttaa tttgcctgtg      960

tgggacccaa gggtaaaccc cagtgatagg taccatctta tgcctataat tacaccagca     1020

tacccacagc agaactccac gtacaatgtg tccgtttcaa cacggatggt catggttgag     1080

gagtttaaac aaggtcttgc tatcacagat gaaattttgc tgagtaaggc agagtggtcc     1140

aaactttttg aagctccaaa cttctttcag aagtacaagc attatattgt acttctagca     1200

agtgcgccca cggaaaagca gcgtctggaa tgggtgggct tggtggaatc aaaaatccgc     1260

atcctggttg gaagcttgga gaagaatgag tttattacac tggctcatgt gaatccccag     1320

tcatttccag cccccaaaga aagtcctgac agggaagaat ttcgcacaat gtgggtgatt     1380

gggttagtgt ttaaaaaaac tgaaaactct gaaaatctca gtgtcgacct cacctatgat     1440

atccagtctt tcacagacac agtttatagg caagcaataa acagcaaaat gtttgagttg     1500

gatatgaaga ttgcagcaat gcatgtgaag agaaagcaac tccatcagct gctgcctagt     1560

cacgtgcttc agaagaggaa gaagcattca acagaaggag tcaagttaac agctctgaat     1620

gacagcagcc ttgacttgtc tatggacagt gataacagca tgtctgtgcc ttcacccacc     1680

agtgctatga agaccagtcc attgaatagt tctggcagct cccagggcag aaacagtcct     1740

gctccagctg tgaccgcagc atctgtgacc agcatccagg cttctgaggt ttctgtaccg     1800

caagcaaatt ccagtgaaag cccagggggt ccatcgagcg aaagcattcc tcaaactgcc     1860

acacagccag ccattgcccc accaccaaag cctacagtct ccagagttgt ctcctcaaca     1920

cgactggtaa acccatcgcc tagaccttca ggaaacacag caacaaaagt ccctaatcct     1980

atagtaggag tcaagagaac gtccgccccc aataaagaag aagcccctag aaggaccaaa     2040

acagaagagg atgaaacaag tgaagatgct aactgtcttg ctttgagtgg acatgataaa     2100

acagagacaa aggaacaagt tgatctggag acaagtgcgg ttcaatcaga aactgttccg     2160

gcatcggctt ctctgttggc ctctcagaaa acatccagta cagacctttc tgatatccct     2220

gctctccctg caaatcctat tcctgttatc aagaactcaa taaaactgag actgaatcgg     2280

ggaggaggag gctctggtgg tggcgggagc agcaagatct acatcgacga gagaagcgac     2340

gccgagatcg tgtgcgccgc catcaagaac atcggcatcg agggcgccac cgccgcccag     2400

ctgaccagac agctgaacat ggagaagaga gaggtgaaca aggccctgta cgacctgcag     2460

agaagcgcca tggtgtacag cagcgacgac atccccccca gatggttcat gaccaccgag     2520

gccgacaagc ccgacgccga cgccatggcc gacgtgatca tcgacgacgt gagcagagag     2580

aagagcatga gagaggacca caagagcttc gacgacgtga tccccgccaa gaagatcatc     2640

gactggaagg acgccgaccc caatacagtc tcctcttttc aagtggactg ttttttgtgg     2700

catgttcgaa agcgggttgc tgaccaagag ctgggggatg ccccgtttct agaccggcta     2760

cggagagacc aaaagagctt gcgtgggaga ggcagtaccc tgggcctcga catcgagacc     2820

gctacacgcg ccggcaagca gatcgtggaa cgcatcttaa aagaggagtc cggaggcggg     2880

ggaagtggag ggggcggcag taggatggct cagttggagg ctaaggtaga ggaactattg     2940

tccaaaaatt ggaatctcga gaacgaagta gctcgcctca agaaactggt cggcgagcgc     3000

ggatcaggcc cgcgacccct ccttgccatc cacccaaccg aggcacggca caagcagaaa     3060

atagtggcac ccgttaagca gactctcaac tttgatctcc tgaagcttgc cggcgacgta     3120

gagtccaacc ccggccccgc cagcctggac aacctggtgg ccagatacca gcggtgcttc     3180

aacgaccaga gcctgaagaa cagcaccatc gagctggaaa tccggttcca gcagatcaac     3240

ttcctgctgt tcaagaccgt gtacgaggcc ctggtcgccc aggaaatccc cagcaccatc     3300

agccacagca tccggtgcat caagaaggtg caccacgaga accactgccg ggagaagatc     3360

ctgcccagcg agaacctgta cttcaagaaa cagcccctga tgttcttcaa gttcagcgag     3420

cccgccagcc tgggctgtaa agtgtccctg gccatcgagc agcccatccg gaagttcatc     3480

ctggacagca gcgtgctggt ccggctgaag aaccggacca ccttccgggt gtccgagctg     3540

tggaagatcg agctgaccat cgtgaagcag ctgatgggca gcgaggtgtc agccaagctg     3600

gccgccttca agaccctgct gttcgacacc cccgagcagc agaccaccaa gaacatgatg     3660

accctgatca accccgacga cgagtacctg tacgagatcg agatcgagta caccggcaag     3720

cctgagagcc tgacagccgc cgacgtgatc aagatcaaga acaccgtgct gacactgatc     3780

agccccaacc acctgatgct gaccgcctac caccaggcca tcgagtttat cgccagccac     3840

atcctgagca gcgagatcct gctggcccgg atcaagagcg gcaagtgggg cctgaagaga     3900

ctgctgcccc aggtcaagtc catgaccaag gccgactaca tgaagttcta cccccccgtg     3960

ggctactacg tgaccgacaa ggccgacggc atccggggca ttgccgtgat ccaggacacc     4020

cagatctacg tggtggccga ccagctgtac agcctgggca ccaccggcat cgagcccctg     4080

aagcccacca tcctggacgg cgagttcatg cccgagaaga aagagttcta cggctttgac     4140

gtgatcatgt acgagggcaa cctgctgacc cagcagggct tcgagacacg gatcgagagc     4200

ctgagcaagg gcatcaaggt gctgcaggcc ttcaacatca aggccgagat gaagcccttc     4260

atcagcctga cctccgccga ccccaacgtg ctgctgaaga atttcgagag catcttcaag     4320

aagaaaaccc ggccctacag catcgacggc atcatcctgg tggagcccgg caacagctac     4380

ctgaacacca acaccttcaa gtggaagccc acctgggaca acaccctgga ctttctggtc     4440

cggaagtgcc ccgagtccct gaacgtgccc gagtacgccc ccaagaaggg cttcagcctg     4500

catctgctgt tcgtgggcat cagcggcgag ctgtttaaga agctggccct gaactggtgc     4560

cccggctaca ccaagctgtt ccccgtgacc cagcggaacc agaactactt ccccgtgcag     4620

ttccagccca gcgacttccc cctggccttc ctgtactacc accccgacac cagcagcttc     4680

agcaacatcg atggcaaggt gctggaaatg cggtgcctga agcgggagat caactacgtg     4740

cgctgggaga tcgtgaagat ccgggaggac cggcagcagg atctgaaaac cggcggctac     4800

ttcggcaacg acttcaagac cgccgagctg acctggctga actacatgga ccccttcagc     4860

ttcgaggaac tggccaaggg acccagcggc atgtacttcg ctggcgccaa gaccggcatc     4920

tacagagccc agaccgccct gatcagcttc atcaagcagg aaatcatcca gaagatcagc     4980

caccagagct gggtgatcga cctgggcatc ggcaagggcc aggacctggg cagatacctg     5040

gacgccggcg tgagacacct ggtcggcatc gataaggacc agacagccct ggccgagctg     5100

gtgtaccgga agttctccca cgccaccacc agacagcaca agcacgccac caacatctac     5160

gtgctgcacc aggatctggc cgagcctgcc aaagaaatca gcgagaaagt gcaccagatc     5220

tatggcttcc ccaaagaggg cgccagcagc atcgtgtcca acctgttcat ccactacctg     5280

atgaagaaca cccagcaggt cgagaacctg gctgtgctgt gccacaagct gctgcagcct     5340

ggcggcatgg tctggttcac caccatgctg ggcgaacagg tgctggaact gctgcacgag     5400

aaccggatcg aactgaacga agtgtgggag gcccgggaga acgaggtggt caagttcgcc     5460

atcaagcggc tgttcaaaga ggacatcctg caggaaaccg gccaggaaat cggcgtcctg     5520

ctgcccttca gcaacggcga cttctacaat gagtacctgg tcaacaccgc ctttctgatc     5580

aagattttca agcaccatgg ctttagcctc gtgcagaagc agagcttcaa ggactggatc     5640

cccgagttcc agaacttcag caagagcctg tacaagatcc tgaccgaggc cgacaagacc     5700

tggaccagcc tgttcggctt catctgcctg cggaagaacg gaggcggggg aagtggaggg     5760

ggcggcagtc aggacctgca cgccatccag ctgcagctcg aagaggaaat gttcaacggc     5820

ggcatcagaa gattcgaggc cgaccagcag agacagatcg cctctggcaa cgagagcgac     5880

accgcctgga atagaaggct gctgtctgag ctgatcgccc ctatggccga aggcatccag     5940

gcctacaaag aggaatacga gggcaagaga ggcagagccc ctagagccct ggccttcatc     6000

aactgtgtgg gcaatgaggt ggccgcctac atcaccatga agatcgtgat ggacatgctg     6060

aacaccgacg tgaccctgca ggccattgcc atgaacgtgg ccgacagaat cgaggaccag     6120

gtccgattca gcaagctgga aggacacgcc gccaagtact tcgagaaagt gaagaagtcc     6180

ctgaaggcca gcaagaccaa gagctacaga cacgcccaca acgtggccgt ggtggccgaa     6240

aaatctgtgg ccgataggga cgccgacttc tctagatggg aggcctggcc taaggacacc     6300

ctgctgcaga tcggcatgac cctgctggaa atcctggaaa acagcgtgtt cttcaacggc     6360

cagcccgtgt tcctgagaac cctgaggaca aatggcggca agcacggcgt gtactacctg     6420

cagacatctg agcacgtggg cgagtggatc accgccttca aagaacatgt ggcccagctg     6480

agccctgcct atgccccttg tgtgatccct cctagaccct gggtgtcccc tttcaatggc     6540

ggctttcaca ccgagaaggt ggccagcaga atcagactgg tcaagggcaa ccgggaacac     6600

gtgcggaagc tgaccaagaa acagatgccc gccgtgtaca aggccgtgaa tgctctgcag     6660

gccaccaagt ggcaggtcaa caaagaggtg ctgcaggtcg tcgaggacgt gatcagactg     6720

gatctgggct acggcgtgcc aagctttaag cccctgatcg acagagagaa caagcccgcc     6780

aaccctgtgc ccctggaatt tcagcacctg agaggccgcg agctgaaaga gatgctgaca     6840

cctgaacagt ggcaggcctt tatcaattgg aagggcgagt gcaccaagct gtacaccgcc     6900

gagacaaaga ggggctctaa gtctgccgcc acagtgcgaa tggtcggaca ggccagaaag     6960

tacagccagt tcgacgccat ctacttcgtg tacgccctgg acagccggtc tagagtgtat     7020

gcccagagca gcacactgag cccccagtct aacgatctgg gaaaggccct gctgagattc     7080

accgagggcc agagactgga ttctgccgaa gccctgaagt ggttcctggt caacggcgcc     7140

aacaactggg gctgggacaa gaaaaccttc gatgtgcgga ccgccaacgt gctggatagc     7200

gagttccagg acatgtgcag agatatcgcc gccgaccctc tgacctttac ccagtgggtc     7260

aacgccgata gcccctatgg attcctggcc tggtgcttcg agtacgccag atacctggac     7320

gccctggatg agggaaccca ggatcagttc atgacccatc tgcccgtgca ccaggatggc     7380

tcttgttctg gcatccagca ctacagcgcc atgctgagcg atgccgtggg agccaaagcc     7440

gtgaacctga agcctagcga cagcccccag gatatctatg gcgctgtggc ccaggtggtc     7500

atccagaaaa actacgccta catgaacgcc gaggacgccg agacattcac aagcggaagc     7560

gtgacactga caggcgccga gctgagatct atggcctctg cctgggacat gatcggcatc     7620

acacggggcc tgaccaaaaa gcctgtgatg acactgccct acggcagcac cagactgacc     7680

tgtagagaaa gcgtgatcga ctacatcgtg gacctggaag agaaagaggc ccagagagcc     7740

attgccgagg gcagaacagc caatcctgtg caccccttcg acaacgaccg gaaggatagc     7800

ctgacaccta gcgccgccta caactacatg accgccctga tctggcccag catctctgaa     7860

gtggtcaagg cccctatcgt ggccatgaag atgatcagac agctggccag attcgccgcc     7920

aagagaaatg agggcctgga ataccctctg cccaccggct ttatcctgca gcagaaaatc     7980

atggccaccg acatgctgcg ggtgtccaca tgtctgatgg gcgagatcaa gatgagcctg     8040

cagatcgaga cagacgtggt ggacgagaca gccatgatgg gagccgccgc tcctaatttt     8100

gtgcacggac acgatgccag ccacctgatc ctgaccgtgt gcgatctggt ggacaagggc     8160

atcactagcg tggccgtgat ccacgatagc tttggaacac acgccggcag aaccgccgac     8220

ctgagagatt ctctgcggga agagatggtc aagatgtacc agaaccacaa cgccctgcag     8280

aacctgctgg acgtgcacga agaaagatgg ctggtggaca ccggcatcca ggtgccagaa     8340

cagggagagt tcgacctgaa cgagatcctg gtgtccgact actgcttcgc ctga           8394


<210>  22
<211>  2797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pC3P3-G3b plasmid

<400>  22

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn Pro Phe Pro Val Thr Thr Gln Gly Ser Gln 
            20                  25                  30          


Gln Thr Gln Pro Pro Gln Arg His Tyr Gly Ile Thr Ser Pro Ile Ser 
        35                  40                  45              


Leu Ala Ala Pro Lys Glu Thr Asp Cys Leu Leu Thr Gln Lys Leu Ile 
    50                  55                  60                  


Glu Thr Leu Lys Pro Phe Gly Val Phe Glu Glu Glu Glu Glu Leu Gln 
65                  70                  75                  80  


Arg Arg Ile Leu Ile Leu Gly Lys Leu Asn Asn Leu Val Lys Glu Trp 
                85                  90                  95      


Ile Arg Glu Ile Ser Glu Ser Lys Asn Leu Pro Gln Ser Val Ile Glu 
            100                 105                 110         


Asn Val Gly Gly Lys Ile Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val 
        115                 120                 125             


His Thr Lys Gly Ala Asp Ile Asp Ala Leu Cys Val Ala Pro Arg His 
    130                 135                 140                 


Val Asp Arg Ser Asp Phe Phe Thr Ser Phe Tyr Asp Lys Leu Lys Leu 
145                 150                 155                 160 


Gln Glu Glu Val Lys Asp Leu Arg Ala Val Glu Glu Ala Phe Val Pro 
                165                 170                 175     


Val Ile Lys Leu Cys Phe Asp Gly Ile Glu Ile Asp Ile Leu Phe Ala 
            180                 185                 190         


Arg Leu Ala Leu Gln Thr Ile Pro Glu Asp Leu Asp Leu Arg Asp Asp 
        195                 200                 205             


Ser Leu Leu Lys Asn Leu Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly 
    210                 215                 220                 


Cys Arg Val Thr Asp Glu Ile Leu His Leu Val Pro Asn Ile Asp Asn 
225                 230                 235                 240 


Phe Arg Leu Thr Leu Arg Ala Ile Lys Leu Trp Ala Lys Arg His Asn 
                245                 250                 255     


Ile Tyr Ser Asn Ile Leu Gly Phe Leu Gly Gly Val Ser Trp Ala Met 
            260                 265                 270         


Leu Val Ala Arg Thr Cys Gln Leu Tyr Pro Asn Ala Ile Ala Ser Thr 
        275                 280                 285             


Leu Val His Lys Phe Phe Leu Val Phe Ser Lys Trp Glu Trp Pro Asn 
    290                 295                 300                 


Pro Val Leu Leu Lys Gln Pro Glu Glu Cys Asn Leu Asn Leu Pro Val 
305                 310                 315                 320 


Trp Asp Pro Arg Val Asn Pro Ser Asp Arg Tyr His Leu Met Pro Ile 
                325                 330                 335     


Ile Thr Pro Ala Tyr Pro Gln Gln Asn Ser Thr Tyr Asn Val Ser Val 
            340                 345                 350         


Ser Thr Arg Met Val Met Val Glu Glu Phe Lys Gln Gly Leu Ala Ile 
        355                 360                 365             


Thr Asp Glu Ile Leu Leu Ser Lys Ala Glu Trp Ser Lys Leu Phe Glu 
    370                 375                 380                 


Ala Pro Asn Phe Phe Gln Lys Tyr Lys His Tyr Ile Val Leu Leu Ala 
385                 390                 395                 400 


Ser Ala Pro Thr Glu Lys Gln Arg Leu Glu Trp Val Gly Leu Val Glu 
                405                 410                 415     


Ser Lys Ile Arg Ile Leu Val Gly Ser Leu Glu Lys Asn Glu Phe Ile 
            420                 425                 430         


Thr Leu Ala His Val Asn Pro Gln Ser Phe Pro Ala Pro Lys Glu Ser 
        435                 440                 445             


Pro Asp Arg Glu Glu Phe Arg Thr Met Trp Val Ile Gly Leu Val Phe 
    450                 455                 460                 


Lys Lys Thr Glu Asn Ser Glu Asn Leu Ser Val Asp Leu Thr Tyr Asp 
465                 470                 475                 480 


Ile Gln Ser Phe Thr Asp Thr Val Tyr Arg Gln Ala Ile Asn Ser Lys 
                485                 490                 495     


Met Phe Glu Leu Asp Met Lys Ile Ala Ala Met His Val Lys Arg Lys 
            500                 505                 510         


Gln Leu His Gln Leu Leu Pro Ser His Val Leu Gln Lys Arg Lys Lys 
        515                 520                 525             


His Ser Thr Glu Gly Val Lys Leu Thr Ala Leu Asn Asp Ser Ser Leu 
    530                 535                 540                 


Asp Leu Ser Met Asp Ser Asp Asn Ser Met Ser Val Pro Ser Pro Thr 
545                 550                 555                 560 


Ser Ala Met Lys Thr Ser Pro Leu Asn Ser Ser Gly Ser Ser Gln Gly 
                565                 570                 575     


Arg Asn Ser Pro Ala Pro Ala Val Thr Ala Ala Ser Val Thr Ser Ile 
            580                 585                 590         


Gln Ala Ser Glu Val Ser Val Pro Gln Ala Asn Ser Ser Glu Ser Pro 
        595                 600                 605             


Gly Gly Pro Ser Ser Glu Ser Ile Pro Gln Thr Ala Thr Gln Pro Ala 
    610                 615                 620                 


Ile Ala Pro Pro Pro Lys Pro Thr Val Ser Arg Val Val Ser Ser Thr 
625                 630                 635                 640 


Arg Leu Val Asn Pro Ser Pro Arg Pro Ser Gly Asn Thr Ala Thr Lys 
                645                 650                 655     


Val Pro Asn Pro Ile Val Gly Val Lys Arg Thr Ser Ala Pro Asn Lys 
            660                 665                 670         


Glu Glu Ala Pro Arg Arg Thr Lys Thr Glu Glu Asp Glu Thr Ser Glu 
        675                 680                 685             


Asp Ala Asn Cys Leu Ala Leu Ser Gly His Asp Lys Thr Glu Thr Lys 
    690                 695                 700                 


Glu Gln Val Asp Leu Glu Thr Ser Ala Val Gln Ser Glu Thr Val Pro 
705                 710                 715                 720 


Ala Ser Ala Ser Leu Leu Ala Ser Gln Lys Thr Ser Ser Thr Asp Leu 
                725                 730                 735     


Ser Asp Ile Pro Ala Leu Pro Ala Asn Pro Ile Pro Val Ile Lys Asn 
            740                 745                 750         


Ser Ile Lys Leu Arg Leu Asn Arg Gly Gly Gly Gly Ser Gly Gly Gly 
        755                 760                 765             


Gly Ser Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val 
    770                 775                 780                 


Cys Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln 
785                 790                 795                 800 


Leu Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu 
                805                 810                 815     


Tyr Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro 
            820                 825                 830         


Pro Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala 
        835                 840                 845             


Met Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg 
    850                 855                 860                 


Glu Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile 
865                 870                 875                 880 


Asp Trp Lys Asp Ala Asp Pro Asn Thr Val Ser Ser Phe Gln Val Asp 
                885                 890                 895     


Cys Phe Leu Trp His Val Arg Lys Arg Val Ala Asp Gln Glu Leu Gly 
            900                 905                 910         


Asp Ala Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg 
        915                 920                 925             


Gly Arg Gly Ser Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr Arg Ala 
    930                 935                 940                 


Gly Lys Gln Ile Val Glu Arg Ile Leu Lys Glu Glu Ser Gly Gly Gly 
945                 950                 955                 960 


Gly Ser Gly Gly Gly Gly Ser Arg Met Ala Gln Leu Glu Ala Lys Val 
                965                 970                 975     


Glu Glu Leu Leu Ser Lys Asn Trp Asn Leu Glu Asn Glu Val Ala Arg 
            980                 985                 990         


Leu Lys Lys Leu Val Gly Glu Arg  Gly Ser Gly Pro Arg  Pro Leu Leu 
        995                 1000                 1005             


Ala Ile  His Pro Thr Glu Ala  Arg His Lys Gln Lys  Ile Val Ala 
    1010                 1015                 1020             


Pro Val  Lys Gln Thr Leu Asn  Phe Asp Leu Leu Lys  Leu Ala Gly 
    1025                 1030                 1035             


Asp Val  Glu Ser Asn Pro Gly  Pro Ala Ser Leu Asp  Asn Leu Val 
    1040                 1045                 1050             


Ala Arg  Tyr Gln Arg Cys Phe  Asn Asp Gln Ser Leu  Lys Asn Ser 
    1055                 1060                 1065             


Thr Ile  Glu Leu Glu Ile Arg  Phe Gln Gln Ile Asn  Phe Leu Leu 
    1070                 1075                 1080             


Phe Lys  Thr Val Tyr Glu Ala  Leu Val Ala Gln Glu  Ile Pro Ser 
    1085                 1090                 1095             


Thr Ile  Ser His Ser Ile Arg  Cys Ile Lys Lys Val  His His Glu 
    1100                 1105                 1110             


Asn His  Cys Arg Glu Lys Ile  Leu Pro Ser Glu Asn  Leu Tyr Phe 
    1115                 1120                 1125             


Lys Lys  Gln Pro Leu Met Phe  Phe Lys Phe Ser Glu  Pro Ala Ser 
    1130                 1135                 1140             


Leu Gly  Cys Lys Val Ser Leu  Ala Ile Glu Gln Pro  Ile Arg Lys 
    1145                 1150                 1155             


Phe Ile  Leu Asp Ser Ser Val  Leu Val Arg Leu Lys  Asn Arg Thr 
    1160                 1165                 1170             


Thr Phe  Arg Val Ser Glu Leu  Trp Lys Ile Glu Leu  Thr Ile Val 
    1175                 1180                 1185             


Lys Gln  Leu Met Gly Ser Glu  Val Ser Ala Lys Leu  Ala Ala Phe 
    1190                 1195                 1200             


Lys Thr  Leu Leu Phe Asp Thr  Pro Glu Gln Gln Thr  Thr Lys Asn 
    1205                 1210                 1215             


Met Met  Thr Leu Ile Asn Pro  Asp Asp Glu Tyr Leu  Tyr Glu Ile 
    1220                 1225                 1230             


Glu Ile  Glu Tyr Thr Gly Lys  Pro Glu Ser Leu Thr  Ala Ala Asp 
    1235                 1240                 1245             


Val Ile  Lys Ile Lys Asn Thr  Val Leu Thr Leu Ile  Ser Pro Asn 
    1250                 1255                 1260             


His Leu  Met Leu Thr Ala Tyr  His Gln Ala Ile Glu  Phe Ile Ala 
    1265                 1270                 1275             


Ser His  Ile Leu Ser Ser Glu  Ile Leu Leu Ala Arg  Ile Lys Ser 
    1280                 1285                 1290             


Gly Lys  Trp Gly Leu Lys Arg  Leu Leu Pro Gln Val  Lys Ser Met 
    1295                 1300                 1305             


Thr Lys  Ala Asp Tyr Met Lys  Phe Tyr Pro Pro Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Val Thr  Asp Lys Ala Asp Gly  Ile Arg Gly Ile Ala  Val Ile Gln 
    1325                 1330                 1335             


Asp Thr  Gln Ile Tyr Val Val  Ala Asp Gln Leu Tyr  Ser Leu Gly 
    1340                 1345                 1350             


Thr Thr  Gly Ile Glu Pro Leu  Lys Pro Thr Ile Leu  Asp Gly Glu 
    1355                 1360                 1365             


Phe Met  Pro Glu Lys Lys Glu  Phe Tyr Gly Phe Asp  Val Ile Met 
    1370                 1375                 1380             


Tyr Glu  Gly Asn Leu Leu Thr  Gln Gln Gly Phe Glu  Thr Arg Ile 
    1385                 1390                 1395             


Glu Ser  Leu Ser Lys Gly Ile  Lys Val Leu Gln Ala  Phe Asn Ile 
    1400                 1405                 1410             


Lys Ala  Glu Met Lys Pro Phe  Ile Ser Leu Thr Ser  Ala Asp Pro 
    1415                 1420                 1425             


Asn Val  Leu Leu Lys Asn Phe  Glu Ser Ile Phe Lys  Lys Lys Thr 
    1430                 1435                 1440             


Arg Pro  Tyr Ser Ile Asp Gly  Ile Ile Leu Val Glu  Pro Gly Asn 
    1445                 1450                 1455             


Ser Tyr  Leu Asn Thr Asn Thr  Phe Lys Trp Lys Pro  Thr Trp Asp 
    1460                 1465                 1470             


Asn Thr  Leu Asp Phe Leu Val  Arg Lys Cys Pro Glu  Ser Leu Asn 
    1475                 1480                 1485             


Val Pro  Glu Tyr Ala Pro Lys  Lys Gly Phe Ser Leu  His Leu Leu 
    1490                 1495                 1500             


Phe Val  Gly Ile Ser Gly Glu  Leu Phe Lys Lys Leu  Ala Leu Asn 
    1505                 1510                 1515             


Trp Cys  Pro Gly Tyr Thr Lys  Leu Phe Pro Val Thr  Gln Arg Asn 
    1520                 1525                 1530             


Gln Asn  Tyr Phe Pro Val Gln  Phe Gln Pro Ser Asp  Phe Pro Leu 
    1535                 1540                 1545             


Ala Phe  Leu Tyr Tyr His Pro  Asp Thr Ser Ser Phe  Ser Asn Ile 
    1550                 1555                 1560             


Asp Gly  Lys Val Leu Glu Met  Arg Cys Leu Lys Arg  Glu Ile Asn 
    1565                 1570                 1575             


Tyr Val  Arg Trp Glu Ile Val  Lys Ile Arg Glu Asp  Arg Gln Gln 
    1580                 1585                 1590             


Asp Leu  Lys Thr Gly Gly Tyr  Phe Gly Asn Asp Phe  Lys Thr Ala 
    1595                 1600                 1605             


Glu Leu  Thr Trp Leu Asn Tyr  Met Asp Pro Phe Ser  Phe Glu Glu 
    1610                 1615                 1620             


Leu Ala  Lys Gly Pro Ser Gly  Met Tyr Phe Ala Gly  Ala Lys Thr 
    1625                 1630                 1635             


Gly Ile  Tyr Arg Ala Gln Thr  Ala Leu Ile Ser Phe  Ile Lys Gln 
    1640                 1645                 1650             


Glu Ile  Ile Gln Lys Ile Ser  His Gln Ser Trp Val  Ile Asp Leu 
    1655                 1660                 1665             


Gly Ile  Gly Lys Gly Gln Asp  Leu Gly Arg Tyr Leu  Asp Ala Gly 
    1670                 1675                 1680             


Val Arg  His Leu Val Gly Ile  Asp Lys Asp Gln Thr  Ala Leu Ala 
    1685                 1690                 1695             


Glu Leu  Val Tyr Arg Lys Phe  Ser His Ala Thr Thr  Arg Gln His 
    1700                 1705                 1710             


Lys His  Ala Thr Asn Ile Tyr  Val Leu His Gln Asp  Leu Ala Glu 
    1715                 1720                 1725             


Pro Ala  Lys Glu Ile Ser Glu  Lys Val His Gln Ile  Tyr Gly Phe 
    1730                 1735                 1740             


Pro Lys  Glu Gly Ala Ser Ser  Ile Val Ser Asn Leu  Phe Ile His 
    1745                 1750                 1755             


Tyr Leu  Met Lys Asn Thr Gln  Gln Val Glu Asn Leu  Ala Val Leu 
    1760                 1765                 1770             


Cys His  Lys Leu Leu Gln Pro  Gly Gly Met Val Trp  Phe Thr Thr 
    1775                 1780                 1785             


Met Leu  Gly Glu Gln Val Leu  Glu Leu Leu His Glu  Asn Arg Ile 
    1790                 1795                 1800             


Glu Leu  Asn Glu Val Trp Glu  Ala Arg Glu Asn Glu  Val Val Lys 
    1805                 1810                 1815             


Phe Ala  Ile Lys Arg Leu Phe  Lys Glu Asp Ile Leu  Gln Glu Thr 
    1820                 1825                 1830             


Gly Gln  Glu Ile Gly Val Leu  Leu Pro Phe Ser Asn  Gly Asp Phe 
    1835                 1840                 1845             


Tyr Asn  Glu Tyr Leu Val Asn  Thr Ala Phe Leu Ile  Lys Ile Phe 
    1850                 1855                 1860             


Lys His  His Gly Phe Ser Leu  Val Gln Lys Gln Ser  Phe Lys Asp 
    1865                 1870                 1875             


Trp Ile  Pro Glu Phe Gln Asn  Phe Ser Lys Ser Leu  Tyr Lys Ile 
    1880                 1885                 1890             


Leu Thr  Glu Ala Asp Lys Thr  Trp Thr Ser Leu Phe  Gly Phe Ile 
    1895                 1900                 1905             


Cys Leu  Arg Lys Asn Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1910                 1915                 1920             


Gln Asp  Leu His Ala Ile Gln  Leu Gln Leu Glu Glu  Glu Met Phe 
    1925                 1930                 1935             


Asn Gly  Gly Ile Arg Arg Phe  Glu Ala Asp Gln Gln  Arg Gln Ile 
    1940                 1945                 1950             


Ala Ser  Gly Asn Glu Ser Asp  Thr Ala Trp Asn Arg  Arg Leu Leu 
    1955                 1960                 1965             


Ser Glu  Leu Ile Ala Pro Met  Ala Glu Gly Ile Gln  Ala Tyr Lys 
    1970                 1975                 1980             


Glu Glu  Tyr Glu Gly Lys Arg  Gly Arg Ala Pro Arg  Ala Leu Ala 
    1985                 1990                 1995             


Phe Ile  Asn Cys Val Gly Asn  Glu Val Ala Ala Tyr  Ile Thr Met 
    2000                 2005                 2010             


Lys Ile  Val Met Asp Met Leu  Asn Thr Asp Val Thr  Leu Gln Ala 
    2015                 2020                 2025             


Ile Ala  Met Asn Val Ala Asp  Arg Ile Glu Asp Gln  Val Arg Phe 
    2030                 2035                 2040             


Ser Lys  Leu Glu Gly His Ala  Ala Lys Tyr Phe Glu  Lys Val Lys 
    2045                 2050                 2055             


Lys Ser  Leu Lys Ala Ser Lys  Thr Lys Ser Tyr Arg  His Ala His 
    2060                 2065                 2070             


Asn Val  Ala Val Val Ala Glu  Lys Ser Val Ala Asp  Arg Asp Ala 
    2075                 2080                 2085             


Asp Phe  Ser Arg Trp Glu Ala  Trp Pro Lys Asp Thr  Leu Leu Gln 
    2090                 2095                 2100             


Ile Gly  Met Thr Leu Leu Glu  Ile Leu Glu Asn Ser  Val Phe Phe 
    2105                 2110                 2115             


Asn Gly  Gln Pro Val Phe Leu  Arg Thr Leu Arg Thr  Asn Gly Gly 
    2120                 2125                 2130             


Lys His  Gly Val Tyr Tyr Leu  Gln Thr Ser Glu His  Val Gly Glu 
    2135                 2140                 2145             


Trp Ile  Thr Ala Phe Lys Glu  His Val Ala Gln Leu  Ser Pro Ala 
    2150                 2155                 2160             


Tyr Ala  Pro Cys Val Ile Pro  Pro Arg Pro Trp Val  Ser Pro Phe 
    2165                 2170                 2175             


Asn Gly  Gly Phe His Thr Glu  Lys Val Ala Ser Arg  Ile Arg Leu 
    2180                 2185                 2190             


Val Lys  Gly Asn Arg Glu His  Val Arg Lys Leu Thr  Lys Lys Gln 
    2195                 2200                 2205             


Met Pro  Ala Val Tyr Lys Ala  Val Asn Ala Leu Gln  Ala Thr Lys 
    2210                 2215                 2220             


Trp Gln  Val Asn Lys Glu Val  Leu Gln Val Val Glu  Asp Val Ile 
    2225                 2230                 2235             


Arg Leu  Asp Leu Gly Tyr Gly  Val Pro Ser Phe Lys  Pro Leu Ile 
    2240                 2245                 2250             


Asp Arg  Glu Asn Lys Pro Ala  Asn Pro Val Pro Leu  Glu Phe Gln 
    2255                 2260                 2265             


His Leu  Arg Gly Arg Glu Leu  Lys Glu Met Leu Thr  Pro Glu Gln 
    2270                 2275                 2280             


Trp Gln  Ala Phe Ile Asn Trp  Lys Gly Glu Cys Thr  Lys Leu Tyr 
    2285                 2290                 2295             


Thr Ala  Glu Thr Lys Arg Gly  Ser Lys Ser Ala Ala  Thr Val Arg 
    2300                 2305                 2310             


Met Val  Gly Gln Ala Arg Lys  Tyr Ser Gln Phe Asp  Ala Ile Tyr 
    2315                 2320                 2325             


Phe Val  Tyr Ala Leu Asp Ser  Arg Ser Arg Val Tyr  Ala Gln Ser 
    2330                 2335                 2340             


Ser Thr  Leu Ser Pro Gln Ser  Asn Asp Leu Gly Lys  Ala Leu Leu 
    2345                 2350                 2355             


Arg Phe  Thr Glu Gly Gln Arg  Leu Asp Ser Ala Glu  Ala Leu Lys 
    2360                 2365                 2370             


Trp Phe  Leu Val Asn Gly Ala  Asn Asn Trp Gly Trp  Asp Lys Lys 
    2375                 2380                 2385             


Thr Phe  Asp Val Arg Thr Ala  Asn Val Leu Asp Ser  Glu Phe Gln 
    2390                 2395                 2400             


Asp Met  Cys Arg Asp Ile Ala  Ala Asp Pro Leu Thr  Phe Thr Gln 
    2405                 2410                 2415             


Trp Val  Asn Ala Asp Ser Pro  Tyr Gly Phe Leu Ala  Trp Cys Phe 
    2420                 2425                 2430             


Glu Tyr  Ala Arg Tyr Leu Asp  Ala Leu Asp Glu Gly  Thr Gln Asp 
    2435                 2440                 2445             


Gln Phe  Met Thr His Leu Pro  Val His Gln Asp Gly  Ser Cys Ser 
    2450                 2455                 2460             


Gly Ile  Gln His Tyr Ser Ala  Met Leu Ser Asp Ala  Val Gly Ala 
    2465                 2470                 2475             


Lys Ala  Val Asn Leu Lys Pro  Ser Asp Ser Pro Gln  Asp Ile Tyr 
    2480                 2485                 2490             


Gly Ala  Val Ala Gln Val Val  Ile Gln Lys Asn Tyr  Ala Tyr Met 
    2495                 2500                 2505             


Asn Ala  Glu Asp Ala Glu Thr  Phe Thr Ser Gly Ser  Val Thr Leu 
    2510                 2515                 2520             


Thr Gly  Ala Glu Leu Arg Ser  Met Ala Ser Ala Trp  Asp Met Ile 
    2525                 2530                 2535             


Gly Ile  Thr Arg Gly Leu Thr  Lys Lys Pro Val Met  Thr Leu Pro 
    2540                 2545                 2550             


Tyr Gly  Ser Thr Arg Leu Thr  Cys Arg Glu Ser Val  Ile Asp Tyr 
    2555                 2560                 2565             


Ile Val  Asp Leu Glu Glu Lys  Glu Ala Gln Arg Ala  Ile Ala Glu 
    2570                 2575                 2580             


Gly Arg  Thr Ala Asn Pro Val  His Pro Phe Asp Asn  Asp Arg Lys 
    2585                 2590                 2595             


Asp Ser  Leu Thr Pro Ser Ala  Ala Tyr Asn Tyr Met  Thr Ala Leu 
    2600                 2605                 2610             


Ile Trp  Pro Ser Ile Ser Glu  Val Val Lys Ala Pro  Ile Val Ala 
    2615                 2620                 2625             


Met Lys  Met Ile Arg Gln Leu  Ala Arg Phe Ala Ala  Lys Arg Asn 
    2630                 2635                 2640             


Glu Gly  Leu Glu Tyr Pro Leu  Pro Thr Gly Phe Ile  Leu Gln Gln 
    2645                 2650                 2655             


Lys Ile  Met Ala Thr Asp Met  Leu Arg Val Ser Thr  Cys Leu Met 
    2660                 2665                 2670             


Gly Glu  Ile Lys Met Ser Leu  Gln Ile Glu Thr Asp  Val Val Asp 
    2675                 2680                 2685             


Glu Thr  Ala Met Met Gly Ala  Ala Ala Pro Asn Phe  Val His Gly 
    2690                 2695                 2700             


His Asp  Ala Ser His Leu Ile  Leu Thr Val Cys Asp  Leu Val Asp 
    2705                 2710                 2715             


Lys Gly  Ile Thr Ser Val Ala  Val Ile His Asp Ser  Phe Gly Thr 
    2720                 2725                 2730             


His Ala  Gly Arg Thr Ala Asp  Leu Arg Asp Ser Leu  Arg Glu Glu 
    2735                 2740                 2745             


Met Val  Lys Met Tyr Gln Asn  His Asn Ala Leu Gln  Asn Leu Leu 
    2750                 2755                 2760             


Asp Val  His Glu Glu Arg Trp  Leu Val Asp Thr Gly  Ile Gln Val 
    2765                 2770                 2775             


Pro Glu  Gln Gly Glu Phe Asp  Leu Asn Glu Ile Leu  Val Ser Asp 
    2780                 2785                 2790             


Tyr Cys  Phe Ala 
    2795         


<210>  23
<211>  8394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pC3P3-G3c plasmid

<400>  23
atggatgctc agaccagacg cagagaacgg cgggcagaga agcaggcaca gtggaaggcc       60

gctaatccgt ttccagttac aacgcaggga tcacaacaaa cgcagccacc acagaggcac      120

tatggcatta cctctcctat cagcttagcg gcccccaagg agactgactg cctactcaca      180

cagaagctca tcgagacgct gaagcccttt ggggtttttg aagaagaaga ggaactgcag      240

cgcaggattt taattttggg aaaattaaat aacctggtga aagaatggat tcgagaaatc      300

agtgaaagca agaatctccc acaatctgta attgaaaatg ttggagggaa gatttttaca      360

tttggatctt acagactagg agtccacacg aaaggtgctg atattgatgc gttgtgtgtt      420

gcaccaagac atgttgatcg aagtgacttt ttcacctcat tctatgataa attgaaatta      480

caagaagaag tgaaagattt aagagctgtt gaagaggcat ttgtaccagt tatcaaactc      540

tgttttgatg gaatagagat tgatattttg tttgcaagat tagcactgca gactattcca      600

gaagatttgg acctacgaga tgacagtctg cttaaaaacc tagatataag atgcataaga      660

agccttaatg gttgcagggt aaccgatgaa attttacatc tagtaccaaa cattgacaac      720

ttcaggttaa ctctgagagc catcaaactg tgggccaaac ggcacaacat ctattccaat      780

atattaggtt tcctcggtgg tgtttcctgg gctatgctag tagcaagaac ttgccagctt      840

tatccaaatg caatagcatc aactcttgta cataaatttt tcttggtatt ttctaaatgg      900

gaatggccaa atccagtgct attgaaacag cctgaagaat gcaatcttaa tttgcctgtg      960

tgggacccaa gggtaaaccc cagtgatagg taccatctta tgcctataat tacaccagca     1020

tacccacagc agaactccac gtacaatgtg tccgtttcaa cacggatggt catggttgag     1080

gagtttaaac aaggtcttgc tatcacagat gaaattttgc tgagtaaggc agagtggtcc     1140

aaactttttg aagctccaaa cttctttcag aagtacaagc attatattgt acttctagca     1200

agtgcgccca cggaaaagca gcgtctggaa tgggtgggct tggtggaatc aaaaatccgc     1260

atcctggttg gaagcttgga gaagaatgag tttattacac tggctcatgt gaatccccag     1320

tcatttccag cccccaaaga aagtcctgac agggaagaat ttcgcacaat gtgggtgatt     1380

gggttagtgt ttaaaaaaac tgaaaactct gaaaatctca gtgtcgacct cacctatgat     1440

atccagtctt tcacagacac agtttatagg caagcaataa acagcaaaat gtttgagttg     1500

gatatgaaga ttgcagcaat gcatgtgaag agaaagcaac tccatcagct gctgcctagt     1560

cacgtgcttc agaagaggaa gaagcattca acagaaggag tcaagttaac agctctgaat     1620

gacagcagcc ttgacttgtc tatggacagt gataacagca tgtctgtgcc ttcacccacc     1680

agtgctatga agaccagtcc attgaatagt tctggcagct cccagggcag aaacagtcct     1740

gctccagctg tgaccgcagc atctgtgacc agcatccagg cttctgaggt ttctgtaccg     1800

caagcaaatt ccagtgaaag cccagggggt ccatcgagcg aaagcattcc tcaaactgcc     1860

acacagccag ccattgcccc accaccaaag cctacagtct ccagagttgt ctcctcaaca     1920

cgactggtaa acccatcgcc tagaccttca ggaaacacag caacaaaagt ccctaatcct     1980

atagtaggag tcaagagaac gtccgccccc aataaagaag aagcccctag aaggaccaaa     2040

acagaagagg atgaaacaag tgaagatgct aactgtcttg ctttgagtgg acatgataaa     2100

acagagacaa aggaacaagt tgatctggag acaagtgcgg ttcaatcaga aactgttccg     2160

gcatcggctt ctctgttggc ctctcagaaa acatccagta cagacctttc tgatatccct     2220

gctctccctg caaatcctat tcctgttatc aagaactcaa taaaactgag actgaatcgg     2280

ggatcaggcc ctcgcccact gctcgcaatc caccctactg aagcaaggca caagcaaaaa     2340

attgtggctc ctgtgaagca gacgctgaac tttgatctgc tgaagctcgc tggcgacgtg     2400

gagtcgaacc ctggccctag caagatctac atcgacgaga gaagcgacgc cgagatcgtg     2460

tgcgccgcca tcaagaacat cggcatcgag ggcgccaccg ccgcccagct gaccagacag     2520

ctgaacatgg agaagagaga ggtgaacaag gccctgtacg acctgcagag aagcgccatg     2580

gtgtacagca gcgacgacat cccccccaga tggttcatga ccaccgaggc cgacaagccc     2640

gacgccgacg ccatggccga cgtgatcatc gacgacgtga gcagagagaa gagcatgaga     2700

gaggaccaca agagcttcga cgacgtgatc cccgccaaga agatcatcga ctggaaggac     2760

gccgacccca atacagtctc ctcttttcaa gtggactgtt ttttgtggca tgttcgaaag     2820

cgggttgctg accaagagct gggggatgcc ccgtttctag accggctacg gagagaccaa     2880

aagagcttgc gtgggagagg cagtaccctg ggcctcgaca tcgagaccgc tacacgcgcc     2940

ggcaagcaga tcgtggaacg catcttaaaa gaggagtccg gaggcggggg aagtggaggg     3000

ggcggcagta ggatggctca gttggaggct aaggtagagg aactattgtc caaaaattgg     3060

aatctcgaga acgaagtagc tcgcctcaag aaactggtcg gcgagcgcgg aggaggaggc     3120

tctggtggtg gcgggagcgc cagcctggac aacctggtgg ccagatacca gcggtgcttc     3180

aacgaccaga gcctgaagaa cagcaccatc gagctggaaa tccggttcca gcagatcaac     3240

ttcctgctgt tcaagaccgt gtacgaggcc ctggtcgccc aggaaatccc cagcaccatc     3300

agccacagca tccggtgcat caagaaggtg caccacgaga accactgccg ggagaagatc     3360

ctgcccagcg agaacctgta cttcaagaaa cagcccctga tgttcttcaa gttcagcgag     3420

cccgccagcc tgggctgtaa agtgtccctg gccatcgagc agcccatccg gaagttcatc     3480

ctggacagca gcgtgctggt ccggctgaag aaccggacca ccttccgggt gtccgagctg     3540

tggaagatcg agctgaccat cgtgaagcag ctgatgggca gcgaggtgtc agccaagctg     3600

gccgccttca agaccctgct gttcgacacc cccgagcagc agaccaccaa gaacatgatg     3660

accctgatca accccgacga cgagtacctg tacgagatcg agatcgagta caccggcaag     3720

cctgagagcc tgacagccgc cgacgtgatc aagatcaaga acaccgtgct gacactgatc     3780

agccccaacc acctgatgct gaccgcctac caccaggcca tcgagtttat cgccagccac     3840

atcctgagca gcgagatcct gctggcccgg atcaagagcg gcaagtgggg cctgaagaga     3900

ctgctgcccc aggtcaagtc catgaccaag gccgactaca tgaagttcta cccccccgtg     3960

ggctactacg tgaccgacaa ggccgacggc atccggggca ttgccgtgat ccaggacacc     4020

cagatctacg tggtggccga ccagctgtac agcctgggca ccaccggcat cgagcccctg     4080

aagcccacca tcctggacgg cgagttcatg cccgagaaga aagagttcta cggctttgac     4140

gtgatcatgt acgagggcaa cctgctgacc cagcagggct tcgagacacg gatcgagagc     4200

ctgagcaagg gcatcaaggt gctgcaggcc ttcaacatca aggccgagat gaagcccttc     4260

atcagcctga cctccgccga ccccaacgtg ctgctgaaga atttcgagag catcttcaag     4320

aagaaaaccc ggccctacag catcgacggc atcatcctgg tggagcccgg caacagctac     4380

ctgaacacca acaccttcaa gtggaagccc acctgggaca acaccctgga ctttctggtc     4440

cggaagtgcc ccgagtccct gaacgtgccc gagtacgccc ccaagaaggg cttcagcctg     4500

catctgctgt tcgtgggcat cagcggcgag ctgtttaaga agctggccct gaactggtgc     4560

cccggctaca ccaagctgtt ccccgtgacc cagcggaacc agaactactt ccccgtgcag     4620

ttccagccca gcgacttccc cctggccttc ctgtactacc accccgacac cagcagcttc     4680

agcaacatcg atggcaaggt gctggaaatg cggtgcctga agcgggagat caactacgtg     4740

cgctgggaga tcgtgaagat ccgggaggac cggcagcagg atctgaaaac cggcggctac     4800

ttcggcaacg acttcaagac cgccgagctg acctggctga actacatgga ccccttcagc     4860

ttcgaggaac tggccaaggg acccagcggc atgtacttcg ctggcgccaa gaccggcatc     4920

tacagagccc agaccgccct gatcagcttc atcaagcagg aaatcatcca gaagatcagc     4980

caccagagct gggtgatcga cctgggcatc ggcaagggcc aggacctggg cagatacctg     5040

gacgccggcg tgagacacct ggtcggcatc gataaggacc agacagccct ggccgagctg     5100

gtgtaccgga agttctccca cgccaccacc agacagcaca agcacgccac caacatctac     5160

gtgctgcacc aggatctggc cgagcctgcc aaagaaatca gcgagaaagt gcaccagatc     5220

tatggcttcc ccaaagaggg cgccagcagc atcgtgtcca acctgttcat ccactacctg     5280

atgaagaaca cccagcaggt cgagaacctg gctgtgctgt gccacaagct gctgcagcct     5340

ggcggcatgg tctggttcac caccatgctg ggcgaacagg tgctggaact gctgcacgag     5400

aaccggatcg aactgaacga agtgtgggag gcccgggaga acgaggtggt caagttcgcc     5460

atcaagcggc tgttcaaaga ggacatcctg caggaaaccg gccaggaaat cggcgtcctg     5520

ctgcccttca gcaacggcga cttctacaat gagtacctgg tcaacaccgc ctttctgatc     5580

aagattttca agcaccatgg ctttagcctc gtgcagaagc agagcttcaa ggactggatc     5640

cccgagttcc agaacttcag caagagcctg tacaagatcc tgaccgaggc cgacaagacc     5700

tggaccagcc tgttcggctt catctgcctg cggaagaacg gaggcggggg aagtggaggg     5760

ggcggcagtc aggacctgca cgccatccag ctgcagctcg aagaggaaat gttcaacggc     5820

ggcatcagaa gattcgaggc cgaccagcag agacagatcg cctctggcaa cgagagcgac     5880

accgcctgga atagaaggct gctgtctgag ctgatcgccc ctatggccga aggcatccag     5940

gcctacaaag aggaatacga gggcaagaga ggcagagccc ctagagccct ggccttcatc     6000

aactgtgtgg gcaatgaggt ggccgcctac atcaccatga agatcgtgat ggacatgctg     6060

aacaccgacg tgaccctgca ggccattgcc atgaacgtgg ccgacagaat cgaggaccag     6120

gtccgattca gcaagctgga aggacacgcc gccaagtact tcgagaaagt gaagaagtcc     6180

ctgaaggcca gcaagaccaa gagctacaga cacgcccaca acgtggccgt ggtggccgaa     6240

aaatctgtgg ccgataggga cgccgacttc tctagatggg aggcctggcc taaggacacc     6300

ctgctgcaga tcggcatgac cctgctggaa atcctggaaa acagcgtgtt cttcaacggc     6360

cagcccgtgt tcctgagaac cctgaggaca aatggcggca agcacggcgt gtactacctg     6420

cagacatctg agcacgtggg cgagtggatc accgccttca aagaacatgt ggcccagctg     6480

agccctgcct atgccccttg tgtgatccct cctagaccct gggtgtcccc tttcaatggc     6540

ggctttcaca ccgagaaggt ggccagcaga atcagactgg tcaagggcaa ccgggaacac     6600

gtgcggaagc tgaccaagaa acagatgccc gccgtgtaca aggccgtgaa tgctctgcag     6660

gccaccaagt ggcaggtcaa caaagaggtg ctgcaggtcg tcgaggacgt gatcagactg     6720

gatctgggct acggcgtgcc aagctttaag cccctgatcg acagagagaa caagcccgcc     6780

aaccctgtgc ccctggaatt tcagcacctg agaggccgcg agctgaaaga gatgctgaca     6840

cctgaacagt ggcaggcctt tatcaattgg aagggcgagt gcaccaagct gtacaccgcc     6900

gagacaaaga ggggctctaa gtctgccgcc acagtgcgaa tggtcggaca ggccagaaag     6960

tacagccagt tcgacgccat ctacttcgtg tacgccctgg acagccggtc tagagtgtat     7020

gcccagagca gcacactgag cccccagtct aacgatctgg gaaaggccct gctgagattc     7080

accgagggcc agagactgga ttctgccgaa gccctgaagt ggttcctggt caacggcgcc     7140

aacaactggg gctgggacaa gaaaaccttc gatgtgcgga ccgccaacgt gctggatagc     7200

gagttccagg acatgtgcag agatatcgcc gccgaccctc tgacctttac ccagtgggtc     7260

aacgccgata gcccctatgg attcctggcc tggtgcttcg agtacgccag atacctggac     7320

gccctggatg agggaaccca ggatcagttc atgacccatc tgcccgtgca ccaggatggc     7380

tcttgttctg gcatccagca ctacagcgcc atgctgagcg atgccgtggg agccaaagcc     7440

gtgaacctga agcctagcga cagcccccag gatatctatg gcgctgtggc ccaggtggtc     7500

atccagaaaa actacgccta catgaacgcc gaggacgccg agacattcac aagcggaagc     7560

gtgacactga caggcgccga gctgagatct atggcctctg cctgggacat gatcggcatc     7620

acacggggcc tgaccaaaaa gcctgtgatg acactgccct acggcagcac cagactgacc     7680

tgtagagaaa gcgtgatcga ctacatcgtg gacctggaag agaaagaggc ccagagagcc     7740

attgccgagg gcagaacagc caatcctgtg caccccttcg acaacgaccg gaaggatagc     7800

ctgacaccta gcgccgccta caactacatg accgccctga tctggcccag catctctgaa     7860

gtggtcaagg cccctatcgt ggccatgaag atgatcagac agctggccag attcgccgcc     7920

aagagaaatg agggcctgga ataccctctg cccaccggct ttatcctgca gcagaaaatc     7980

atggccaccg acatgctgcg ggtgtccaca tgtctgatgg gcgagatcaa gatgagcctg     8040

cagatcgaga cagacgtggt ggacgagaca gccatgatgg gagccgccgc tcctaatttt     8100

gtgcacggac acgatgccag ccacctgatc ctgaccgtgt gcgatctggt ggacaagggc     8160

atcactagcg tggccgtgat ccacgatagc tttggaacac acgccggcag aaccgccgac     8220

ctgagagatt ctctgcggga agagatggtc aagatgtacc agaaccacaa cgccctgcag     8280

aacctgctgg acgtgcacga agaaagatgg ctggtggaca ccggcatcca ggtgccagaa     8340

cagggagagt tcgacctgaa cgagatcctg gtgtccgact actgcttcgc ctga           8394


<210>  24
<211>  2797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pC3P3-G3c plasmid

<400>  24

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn Pro Phe Pro Val Thr Thr Gln Gly Ser Gln 
            20                  25                  30          


Gln Thr Gln Pro Pro Gln Arg His Tyr Gly Ile Thr Ser Pro Ile Ser 
        35                  40                  45              


Leu Ala Ala Pro Lys Glu Thr Asp Cys Leu Leu Thr Gln Lys Leu Ile 
    50                  55                  60                  


Glu Thr Leu Lys Pro Phe Gly Val Phe Glu Glu Glu Glu Glu Leu Gln 
65                  70                  75                  80  


Arg Arg Ile Leu Ile Leu Gly Lys Leu Asn Asn Leu Val Lys Glu Trp 
                85                  90                  95      


Ile Arg Glu Ile Ser Glu Ser Lys Asn Leu Pro Gln Ser Val Ile Glu 
            100                 105                 110         


Asn Val Gly Gly Lys Ile Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val 
        115                 120                 125             


His Thr Lys Gly Ala Asp Ile Asp Ala Leu Cys Val Ala Pro Arg His 
    130                 135                 140                 


Val Asp Arg Ser Asp Phe Phe Thr Ser Phe Tyr Asp Lys Leu Lys Leu 
145                 150                 155                 160 


Gln Glu Glu Val Lys Asp Leu Arg Ala Val Glu Glu Ala Phe Val Pro 
                165                 170                 175     


Val Ile Lys Leu Cys Phe Asp Gly Ile Glu Ile Asp Ile Leu Phe Ala 
            180                 185                 190         


Arg Leu Ala Leu Gln Thr Ile Pro Glu Asp Leu Asp Leu Arg Asp Asp 
        195                 200                 205             


Ser Leu Leu Lys Asn Leu Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly 
    210                 215                 220                 


Cys Arg Val Thr Asp Glu Ile Leu His Leu Val Pro Asn Ile Asp Asn 
225                 230                 235                 240 


Phe Arg Leu Thr Leu Arg Ala Ile Lys Leu Trp Ala Lys Arg His Asn 
                245                 250                 255     


Ile Tyr Ser Asn Ile Leu Gly Phe Leu Gly Gly Val Ser Trp Ala Met 
            260                 265                 270         


Leu Val Ala Arg Thr Cys Gln Leu Tyr Pro Asn Ala Ile Ala Ser Thr 
        275                 280                 285             


Leu Val His Lys Phe Phe Leu Val Phe Ser Lys Trp Glu Trp Pro Asn 
    290                 295                 300                 


Pro Val Leu Leu Lys Gln Pro Glu Glu Cys Asn Leu Asn Leu Pro Val 
305                 310                 315                 320 


Trp Asp Pro Arg Val Asn Pro Ser Asp Arg Tyr His Leu Met Pro Ile 
                325                 330                 335     


Ile Thr Pro Ala Tyr Pro Gln Gln Asn Ser Thr Tyr Asn Val Ser Val 
            340                 345                 350         


Ser Thr Arg Met Val Met Val Glu Glu Phe Lys Gln Gly Leu Ala Ile 
        355                 360                 365             


Thr Asp Glu Ile Leu Leu Ser Lys Ala Glu Trp Ser Lys Leu Phe Glu 
    370                 375                 380                 


Ala Pro Asn Phe Phe Gln Lys Tyr Lys His Tyr Ile Val Leu Leu Ala 
385                 390                 395                 400 


Ser Ala Pro Thr Glu Lys Gln Arg Leu Glu Trp Val Gly Leu Val Glu 
                405                 410                 415     


Ser Lys Ile Arg Ile Leu Val Gly Ser Leu Glu Lys Asn Glu Phe Ile 
            420                 425                 430         


Thr Leu Ala His Val Asn Pro Gln Ser Phe Pro Ala Pro Lys Glu Ser 
        435                 440                 445             


Pro Asp Arg Glu Glu Phe Arg Thr Met Trp Val Ile Gly Leu Val Phe 
    450                 455                 460                 


Lys Lys Thr Glu Asn Ser Glu Asn Leu Ser Val Asp Leu Thr Tyr Asp 
465                 470                 475                 480 


Ile Gln Ser Phe Thr Asp Thr Val Tyr Arg Gln Ala Ile Asn Ser Lys 
                485                 490                 495     


Met Phe Glu Leu Asp Met Lys Ile Ala Ala Met His Val Lys Arg Lys 
            500                 505                 510         


Gln Leu His Gln Leu Leu Pro Ser His Val Leu Gln Lys Arg Lys Lys 
        515                 520                 525             


His Ser Thr Glu Gly Val Lys Leu Thr Ala Leu Asn Asp Ser Ser Leu 
    530                 535                 540                 


Asp Leu Ser Met Asp Ser Asp Asn Ser Met Ser Val Pro Ser Pro Thr 
545                 550                 555                 560 


Ser Ala Met Lys Thr Ser Pro Leu Asn Ser Ser Gly Ser Ser Gln Gly 
                565                 570                 575     


Arg Asn Ser Pro Ala Pro Ala Val Thr Ala Ala Ser Val Thr Ser Ile 
            580                 585                 590         


Gln Ala Ser Glu Val Ser Val Pro Gln Ala Asn Ser Ser Glu Ser Pro 
        595                 600                 605             


Gly Gly Pro Ser Ser Glu Ser Ile Pro Gln Thr Ala Thr Gln Pro Ala 
    610                 615                 620                 


Ile Ala Pro Pro Pro Lys Pro Thr Val Ser Arg Val Val Ser Ser Thr 
625                 630                 635                 640 


Arg Leu Val Asn Pro Ser Pro Arg Pro Ser Gly Asn Thr Ala Thr Lys 
                645                 650                 655     


Val Pro Asn Pro Ile Val Gly Val Lys Arg Thr Ser Ala Pro Asn Lys 
            660                 665                 670         


Glu Glu Ala Pro Arg Arg Thr Lys Thr Glu Glu Asp Glu Thr Ser Glu 
        675                 680                 685             


Asp Ala Asn Cys Leu Ala Leu Ser Gly His Asp Lys Thr Glu Thr Lys 
    690                 695                 700                 


Glu Gln Val Asp Leu Glu Thr Ser Ala Val Gln Ser Glu Thr Val Pro 
705                 710                 715                 720 


Ala Ser Ala Ser Leu Leu Ala Ser Gln Lys Thr Ser Ser Thr Asp Leu 
                725                 730                 735     


Ser Asp Ile Pro Ala Leu Pro Ala Asn Pro Ile Pro Val Ile Lys Asn 
            740                 745                 750         


Ser Ile Lys Leu Arg Leu Asn Arg Gly Ser Gly Pro Arg Pro Leu Leu 
        755                 760                 765             


Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro 
    770                 775                 780                 


Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
785                 790                 795                 800 


Glu Ser Asn Pro Gly Pro Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp 
                805                 810                 815     


Ala Glu Ile Val Cys Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala 
            820                 825                 830         


Thr Ala Ala Gln Leu Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val 
        835                 840                 845             


Asn Lys Ala Leu Tyr Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser 
    850                 855                 860                 


Asp Asp Ile Pro Pro Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro 
865                 870                 875                 880 


Asp Ala Asp Ala Met Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu 
                885                 890                 895     


Lys Ser Met Arg Glu Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala 
            900                 905                 910         


Lys Lys Ile Ile Asp Trp Lys Asp Ala Asp Pro Asn Thr Val Ser Ser 
        915                 920                 925             


Phe Gln Val Asp Cys Phe Leu Trp His Val Arg Lys Arg Val Ala Asp 
    930                 935                 940                 


Gln Glu Leu Gly Asp Ala Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln 
945                 950                 955                 960 


Lys Ser Leu Arg Gly Arg Gly Ser Thr Leu Gly Leu Asp Ile Glu Thr 
                965                 970                 975     


Ala Thr Arg Ala Gly Lys Gln Ile Val Glu Arg Ile Leu Lys Glu Glu 
            980                 985                 990         


Ser Gly Gly Gly Gly Ser Gly Gly  Gly Gly Ser Arg Met  Ala Gln Leu 
        995                 1000                 1005             


Glu Ala  Lys Val Glu Glu Leu  Leu Ser Lys Asn Trp  Asn Leu Glu 
    1010                 1015                 1020             


Asn Glu  Val Ala Arg Leu Lys  Lys Leu Val Gly Glu  Arg Gly Gly 
    1025                 1030                 1035             


Gly Gly  Ser Gly Gly Gly Gly  Ser Ala Ser Leu Asp  Asn Leu Val 
    1040                 1045                 1050             


Ala Arg  Tyr Gln Arg Cys Phe  Asn Asp Gln Ser Leu  Lys Asn Ser 
    1055                 1060                 1065             


Thr Ile  Glu Leu Glu Ile Arg  Phe Gln Gln Ile Asn  Phe Leu Leu 
    1070                 1075                 1080             


Phe Lys  Thr Val Tyr Glu Ala  Leu Val Ala Gln Glu  Ile Pro Ser 
    1085                 1090                 1095             


Thr Ile  Ser His Ser Ile Arg  Cys Ile Lys Lys Val  His His Glu 
    1100                 1105                 1110             


Asn His  Cys Arg Glu Lys Ile  Leu Pro Ser Glu Asn  Leu Tyr Phe 
    1115                 1120                 1125             


Lys Lys  Gln Pro Leu Met Phe  Phe Lys Phe Ser Glu  Pro Ala Ser 
    1130                 1135                 1140             


Leu Gly  Cys Lys Val Ser Leu  Ala Ile Glu Gln Pro  Ile Arg Lys 
    1145                 1150                 1155             


Phe Ile  Leu Asp Ser Ser Val  Leu Val Arg Leu Lys  Asn Arg Thr 
    1160                 1165                 1170             


Thr Phe  Arg Val Ser Glu Leu  Trp Lys Ile Glu Leu  Thr Ile Val 
    1175                 1180                 1185             


Lys Gln  Leu Met Gly Ser Glu  Val Ser Ala Lys Leu  Ala Ala Phe 
    1190                 1195                 1200             


Lys Thr  Leu Leu Phe Asp Thr  Pro Glu Gln Gln Thr  Thr Lys Asn 
    1205                 1210                 1215             


Met Met  Thr Leu Ile Asn Pro  Asp Asp Glu Tyr Leu  Tyr Glu Ile 
    1220                 1225                 1230             


Glu Ile  Glu Tyr Thr Gly Lys  Pro Glu Ser Leu Thr  Ala Ala Asp 
    1235                 1240                 1245             


Val Ile  Lys Ile Lys Asn Thr  Val Leu Thr Leu Ile  Ser Pro Asn 
    1250                 1255                 1260             


His Leu  Met Leu Thr Ala Tyr  His Gln Ala Ile Glu  Phe Ile Ala 
    1265                 1270                 1275             


Ser His  Ile Leu Ser Ser Glu  Ile Leu Leu Ala Arg  Ile Lys Ser 
    1280                 1285                 1290             


Gly Lys  Trp Gly Leu Lys Arg  Leu Leu Pro Gln Val  Lys Ser Met 
    1295                 1300                 1305             


Thr Lys  Ala Asp Tyr Met Lys  Phe Tyr Pro Pro Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Val Thr  Asp Lys Ala Asp Gly  Ile Arg Gly Ile Ala  Val Ile Gln 
    1325                 1330                 1335             


Asp Thr  Gln Ile Tyr Val Val  Ala Asp Gln Leu Tyr  Ser Leu Gly 
    1340                 1345                 1350             


Thr Thr  Gly Ile Glu Pro Leu  Lys Pro Thr Ile Leu  Asp Gly Glu 
    1355                 1360                 1365             


Phe Met  Pro Glu Lys Lys Glu  Phe Tyr Gly Phe Asp  Val Ile Met 
    1370                 1375                 1380             


Tyr Glu  Gly Asn Leu Leu Thr  Gln Gln Gly Phe Glu  Thr Arg Ile 
    1385                 1390                 1395             


Glu Ser  Leu Ser Lys Gly Ile  Lys Val Leu Gln Ala  Phe Asn Ile 
    1400                 1405                 1410             


Lys Ala  Glu Met Lys Pro Phe  Ile Ser Leu Thr Ser  Ala Asp Pro 
    1415                 1420                 1425             


Asn Val  Leu Leu Lys Asn Phe  Glu Ser Ile Phe Lys  Lys Lys Thr 
    1430                 1435                 1440             


Arg Pro  Tyr Ser Ile Asp Gly  Ile Ile Leu Val Glu  Pro Gly Asn 
    1445                 1450                 1455             


Ser Tyr  Leu Asn Thr Asn Thr  Phe Lys Trp Lys Pro  Thr Trp Asp 
    1460                 1465                 1470             


Asn Thr  Leu Asp Phe Leu Val  Arg Lys Cys Pro Glu  Ser Leu Asn 
    1475                 1480                 1485             


Val Pro  Glu Tyr Ala Pro Lys  Lys Gly Phe Ser Leu  His Leu Leu 
    1490                 1495                 1500             


Phe Val  Gly Ile Ser Gly Glu  Leu Phe Lys Lys Leu  Ala Leu Asn 
    1505                 1510                 1515             


Trp Cys  Pro Gly Tyr Thr Lys  Leu Phe Pro Val Thr  Gln Arg Asn 
    1520                 1525                 1530             


Gln Asn  Tyr Phe Pro Val Gln  Phe Gln Pro Ser Asp  Phe Pro Leu 
    1535                 1540                 1545             


Ala Phe  Leu Tyr Tyr His Pro  Asp Thr Ser Ser Phe  Ser Asn Ile 
    1550                 1555                 1560             


Asp Gly  Lys Val Leu Glu Met  Arg Cys Leu Lys Arg  Glu Ile Asn 
    1565                 1570                 1575             


Tyr Val  Arg Trp Glu Ile Val  Lys Ile Arg Glu Asp  Arg Gln Gln 
    1580                 1585                 1590             


Asp Leu  Lys Thr Gly Gly Tyr  Phe Gly Asn Asp Phe  Lys Thr Ala 
    1595                 1600                 1605             


Glu Leu  Thr Trp Leu Asn Tyr  Met Asp Pro Phe Ser  Phe Glu Glu 
    1610                 1615                 1620             


Leu Ala  Lys Gly Pro Ser Gly  Met Tyr Phe Ala Gly  Ala Lys Thr 
    1625                 1630                 1635             


Gly Ile  Tyr Arg Ala Gln Thr  Ala Leu Ile Ser Phe  Ile Lys Gln 
    1640                 1645                 1650             


Glu Ile  Ile Gln Lys Ile Ser  His Gln Ser Trp Val  Ile Asp Leu 
    1655                 1660                 1665             


Gly Ile  Gly Lys Gly Gln Asp  Leu Gly Arg Tyr Leu  Asp Ala Gly 
    1670                 1675                 1680             


Val Arg  His Leu Val Gly Ile  Asp Lys Asp Gln Thr  Ala Leu Ala 
    1685                 1690                 1695             


Glu Leu  Val Tyr Arg Lys Phe  Ser His Ala Thr Thr  Arg Gln His 
    1700                 1705                 1710             


Lys His  Ala Thr Asn Ile Tyr  Val Leu His Gln Asp  Leu Ala Glu 
    1715                 1720                 1725             


Pro Ala  Lys Glu Ile Ser Glu  Lys Val His Gln Ile  Tyr Gly Phe 
    1730                 1735                 1740             


Pro Lys  Glu Gly Ala Ser Ser  Ile Val Ser Asn Leu  Phe Ile His 
    1745                 1750                 1755             


Tyr Leu  Met Lys Asn Thr Gln  Gln Val Glu Asn Leu  Ala Val Leu 
    1760                 1765                 1770             


Cys His  Lys Leu Leu Gln Pro  Gly Gly Met Val Trp  Phe Thr Thr 
    1775                 1780                 1785             


Met Leu  Gly Glu Gln Val Leu  Glu Leu Leu His Glu  Asn Arg Ile 
    1790                 1795                 1800             


Glu Leu  Asn Glu Val Trp Glu  Ala Arg Glu Asn Glu  Val Val Lys 
    1805                 1810                 1815             


Phe Ala  Ile Lys Arg Leu Phe  Lys Glu Asp Ile Leu  Gln Glu Thr 
    1820                 1825                 1830             


Gly Gln  Glu Ile Gly Val Leu  Leu Pro Phe Ser Asn  Gly Asp Phe 
    1835                 1840                 1845             


Tyr Asn  Glu Tyr Leu Val Asn  Thr Ala Phe Leu Ile  Lys Ile Phe 
    1850                 1855                 1860             


Lys His  His Gly Phe Ser Leu  Val Gln Lys Gln Ser  Phe Lys Asp 
    1865                 1870                 1875             


Trp Ile  Pro Glu Phe Gln Asn  Phe Ser Lys Ser Leu  Tyr Lys Ile 
    1880                 1885                 1890             


Leu Thr  Glu Ala Asp Lys Thr  Trp Thr Ser Leu Phe  Gly Phe Ile 
    1895                 1900                 1905             


Cys Leu  Arg Lys Asn Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1910                 1915                 1920             


Gln Asp  Leu His Ala Ile Gln  Leu Gln Leu Glu Glu  Glu Met Phe 
    1925                 1930                 1935             


Asn Gly  Gly Ile Arg Arg Phe  Glu Ala Asp Gln Gln  Arg Gln Ile 
    1940                 1945                 1950             


Ala Ser  Gly Asn Glu Ser Asp  Thr Ala Trp Asn Arg  Arg Leu Leu 
    1955                 1960                 1965             


Ser Glu  Leu Ile Ala Pro Met  Ala Glu Gly Ile Gln  Ala Tyr Lys 
    1970                 1975                 1980             


Glu Glu  Tyr Glu Gly Lys Arg  Gly Arg Ala Pro Arg  Ala Leu Ala 
    1985                 1990                 1995             


Phe Ile  Asn Cys Val Gly Asn  Glu Val Ala Ala Tyr  Ile Thr Met 
    2000                 2005                 2010             


Lys Ile  Val Met Asp Met Leu  Asn Thr Asp Val Thr  Leu Gln Ala 
    2015                 2020                 2025             


Ile Ala  Met Asn Val Ala Asp  Arg Ile Glu Asp Gln  Val Arg Phe 
    2030                 2035                 2040             


Ser Lys  Leu Glu Gly His Ala  Ala Lys Tyr Phe Glu  Lys Val Lys 
    2045                 2050                 2055             


Lys Ser  Leu Lys Ala Ser Lys  Thr Lys Ser Tyr Arg  His Ala His 
    2060                 2065                 2070             


Asn Val  Ala Val Val Ala Glu  Lys Ser Val Ala Asp  Arg Asp Ala 
    2075                 2080                 2085             


Asp Phe  Ser Arg Trp Glu Ala  Trp Pro Lys Asp Thr  Leu Leu Gln 
    2090                 2095                 2100             


Ile Gly  Met Thr Leu Leu Glu  Ile Leu Glu Asn Ser  Val Phe Phe 
    2105                 2110                 2115             


Asn Gly  Gln Pro Val Phe Leu  Arg Thr Leu Arg Thr  Asn Gly Gly 
    2120                 2125                 2130             


Lys His  Gly Val Tyr Tyr Leu  Gln Thr Ser Glu His  Val Gly Glu 
    2135                 2140                 2145             


Trp Ile  Thr Ala Phe Lys Glu  His Val Ala Gln Leu  Ser Pro Ala 
    2150                 2155                 2160             


Tyr Ala  Pro Cys Val Ile Pro  Pro Arg Pro Trp Val  Ser Pro Phe 
    2165                 2170                 2175             


Asn Gly  Gly Phe His Thr Glu  Lys Val Ala Ser Arg  Ile Arg Leu 
    2180                 2185                 2190             


Val Lys  Gly Asn Arg Glu His  Val Arg Lys Leu Thr  Lys Lys Gln 
    2195                 2200                 2205             


Met Pro  Ala Val Tyr Lys Ala  Val Asn Ala Leu Gln  Ala Thr Lys 
    2210                 2215                 2220             


Trp Gln  Val Asn Lys Glu Val  Leu Gln Val Val Glu  Asp Val Ile 
    2225                 2230                 2235             


Arg Leu  Asp Leu Gly Tyr Gly  Val Pro Ser Phe Lys  Pro Leu Ile 
    2240                 2245                 2250             


Asp Arg  Glu Asn Lys Pro Ala  Asn Pro Val Pro Leu  Glu Phe Gln 
    2255                 2260                 2265             


His Leu  Arg Gly Arg Glu Leu  Lys Glu Met Leu Thr  Pro Glu Gln 
    2270                 2275                 2280             


Trp Gln  Ala Phe Ile Asn Trp  Lys Gly Glu Cys Thr  Lys Leu Tyr 
    2285                 2290                 2295             


Thr Ala  Glu Thr Lys Arg Gly  Ser Lys Ser Ala Ala  Thr Val Arg 
    2300                 2305                 2310             


Met Val  Gly Gln Ala Arg Lys  Tyr Ser Gln Phe Asp  Ala Ile Tyr 
    2315                 2320                 2325             


Phe Val  Tyr Ala Leu Asp Ser  Arg Ser Arg Val Tyr  Ala Gln Ser 
    2330                 2335                 2340             


Ser Thr  Leu Ser Pro Gln Ser  Asn Asp Leu Gly Lys  Ala Leu Leu 
    2345                 2350                 2355             


Arg Phe  Thr Glu Gly Gln Arg  Leu Asp Ser Ala Glu  Ala Leu Lys 
    2360                 2365                 2370             


Trp Phe  Leu Val Asn Gly Ala  Asn Asn Trp Gly Trp  Asp Lys Lys 
    2375                 2380                 2385             


Thr Phe  Asp Val Arg Thr Ala  Asn Val Leu Asp Ser  Glu Phe Gln 
    2390                 2395                 2400             


Asp Met  Cys Arg Asp Ile Ala  Ala Asp Pro Leu Thr  Phe Thr Gln 
    2405                 2410                 2415             


Trp Val  Asn Ala Asp Ser Pro  Tyr Gly Phe Leu Ala  Trp Cys Phe 
    2420                 2425                 2430             


Glu Tyr  Ala Arg Tyr Leu Asp  Ala Leu Asp Glu Gly  Thr Gln Asp 
    2435                 2440                 2445             


Gln Phe  Met Thr His Leu Pro  Val His Gln Asp Gly  Ser Cys Ser 
    2450                 2455                 2460             


Gly Ile  Gln His Tyr Ser Ala  Met Leu Ser Asp Ala  Val Gly Ala 
    2465                 2470                 2475             


Lys Ala  Val Asn Leu Lys Pro  Ser Asp Ser Pro Gln  Asp Ile Tyr 
    2480                 2485                 2490             


Gly Ala  Val Ala Gln Val Val  Ile Gln Lys Asn Tyr  Ala Tyr Met 
    2495                 2500                 2505             


Asn Ala  Glu Asp Ala Glu Thr  Phe Thr Ser Gly Ser  Val Thr Leu 
    2510                 2515                 2520             


Thr Gly  Ala Glu Leu Arg Ser  Met Ala Ser Ala Trp  Asp Met Ile 
    2525                 2530                 2535             


Gly Ile  Thr Arg Gly Leu Thr  Lys Lys Pro Val Met  Thr Leu Pro 
    2540                 2545                 2550             


Tyr Gly  Ser Thr Arg Leu Thr  Cys Arg Glu Ser Val  Ile Asp Tyr 
    2555                 2560                 2565             


Ile Val  Asp Leu Glu Glu Lys  Glu Ala Gln Arg Ala  Ile Ala Glu 
    2570                 2575                 2580             


Gly Arg  Thr Ala Asn Pro Val  His Pro Phe Asp Asn  Asp Arg Lys 
    2585                 2590                 2595             


Asp Ser  Leu Thr Pro Ser Ala  Ala Tyr Asn Tyr Met  Thr Ala Leu 
    2600                 2605                 2610             


Ile Trp  Pro Ser Ile Ser Glu  Val Val Lys Ala Pro  Ile Val Ala 
    2615                 2620                 2625             


Met Lys  Met Ile Arg Gln Leu  Ala Arg Phe Ala Ala  Lys Arg Asn 
    2630                 2635                 2640             


Glu Gly  Leu Glu Tyr Pro Leu  Pro Thr Gly Phe Ile  Leu Gln Gln 
    2645                 2650                 2655             


Lys Ile  Met Ala Thr Asp Met  Leu Arg Val Ser Thr  Cys Leu Met 
    2660                 2665                 2670             


Gly Glu  Ile Lys Met Ser Leu  Gln Ile Glu Thr Asp  Val Val Asp 
    2675                 2680                 2685             


Glu Thr  Ala Met Met Gly Ala  Ala Ala Pro Asn Phe  Val His Gly 
    2690                 2695                 2700             


His Asp  Ala Ser His Leu Ile  Leu Thr Val Cys Asp  Leu Val Asp 
    2705                 2710                 2715             


Lys Gly  Ile Thr Ser Val Ala  Val Ile His Asp Ser  Phe Gly Thr 
    2720                 2725                 2730             


His Ala  Gly Arg Thr Ala Asp  Leu Arg Asp Ser Leu  Arg Glu Glu 
    2735                 2740                 2745             


Met Val  Lys Met Tyr Gln Asn  His Asn Ala Leu Gln  Asn Leu Leu 
    2750                 2755                 2760             


Asp Val  His Glu Glu Arg Trp  Leu Val Asp Thr Gly  Ile Gln Val 
    2765                 2770                 2775             


Pro Glu  Gln Gly Glu Phe Asp  Leu Asn Glu Ile Leu  Val Ser Asp 
    2780                 2785                 2790             


Tyr Cys  Phe Ala 
    2795         


<210>  25
<211>  8502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pC3P3-G3d plasmid

<400>  25
atgagcaaga tctacatcga cgagagaagc gacgccgaga tcgtgtgcgc cgccatcaag       60

aacatcggca tcgagggcgc caccgccgcc cagctgacca gacagctgaa catggagaag      120

agagaggtga acaaggccct gtacgacctg cagagaagcg ccatggtgta cagcagcgac      180

gacatccccc ccagatggtt catgaccacc gaggccgaca agcccgacgc cgacgccatg      240

gccgacgtga tcatcgacga cgtgagcaga gagaagagca tgagagagga ccacaagagc      300

ttcgacgacg tgatccccgc caagaagatc atcgactgga aggacgccga ccccaataca      360

gtctcctctt ttcaagtgga ctgttttttg tggcatgttc gaaagcgggt tgctgaccaa      420

gagctggggg atgccccgtt tctagaccgg ctacggagag accaaaagag cttgcgtggg      480

agaggcagta ccctgggcct cgacatcgag accgctacac gcgccggcaa gcagatcgtg      540

gaacgcatct taaaagagga gtccggaggc gggggaagtg gagggggcgg cagtaggatg      600

gctcagttgg aggctaaggt agaggaacta ttgtccaaaa attggaatct cgagaacgaa      660

gtagctcgcc tcaagaaact ggtcggcgag cgcggatcag gcccgcgacc cctccttgcc      720

atccacccaa ccgaggcacg gcacaagcag aaaatagtgg cacccgttaa gcagactctc      780

aactttgatc tcctgaagct tgccggcgac gtagagtcca accccggccc cgatgctcag      840

accagacgca gagaacggcg ggcagagaag caggcacagt ggaaggccgc taatccgttt      900

ccagttacaa cgcagggatc acaacaaacg cagccaccac agaggcacta tggcattacc      960

tctcctatca gcttagcggc ccccaaggag actgactgcc tactcacaca gaagctcatc     1020

gagacgctga agccctttgg ggtttttgaa gaagaagagg aactgcagcg caggatttta     1080

attttgggaa aattaaataa cctggtgaaa gaatggattc gagaaatcag tgaaagcaag     1140

aatctcccac aatctgtaat tgaaaatgtt ggagggaaga tttttacatt tggatcttac     1200

agactaggag tccacacgaa aggtgctgat attgatgcgt tgtgtgttgc accaagacat     1260

gttgatcgaa gtgacttttt cacctcattc tatgataaat tgaaattaca agaagaagtg     1320

aaagatttaa gagctgttga agaggcattt gtaccagtta tcaaactctg ttttgatgga     1380

atagagattg atattttgtt tgcaagatta gcactgcaga ctattccaga agatttggac     1440

ctacgagatg acagtctgct taaaaaccta gatataagat gcataagaag ccttaatggt     1500

tgcagggtaa ccgatgaaat tttacatcta gtaccaaaca ttgacaactt caggttaact     1560

ctgagagcca tcaaactgtg ggccaaacgg cacaacatct attccaatat attaggtttc     1620

ctcggtggtg tttcctgggc tatgctagta gcaagaactt gccagcttta tccaaatgca     1680

atagcatcaa ctcttgtaca taaatttttc ttggtatttt ctaaatggga atggccaaat     1740

ccagtgctat tgaaacagcc tgaagaatgc aatcttaatt tgcctgtgtg ggacccaagg     1800

gtaaacccca gtgataggta ccatcttatg cctataatta caccagcata cccacagcag     1860

aactccacgt acaatgtgtc cgtttcaaca cggatggtca tggttgagga gtttaaacaa     1920

ggtcttgcta tcacagatga aattttgctg agtaaggcag agtggtccaa actttttgaa     1980

gctccaaact tctttcagaa gtacaagcat tatattgtac ttctagcaag tgcgcccacg     2040

gaaaagcagc gtctggaatg ggtgggcttg gtggaatcaa aaatccgcat cctggttgga     2100

agcttggaga agaatgagtt tattacactg gctcatgtga atccccagtc atttccagcc     2160

cccaaagaaa gtcctgacag ggaagaattt cgcacaatgt gggtgattgg gttagtgttt     2220

aaaaaaactg aaaactctga aaatctcagt gtcgacctca cctatgatat ccagtctttc     2280

acagacacag tttataggca agcaataaac agcaaaatgt ttgagttgga tatgaagatt     2340

gcagcaatgc atgtgaagag aaagcaactc catcagctgc tgcctagtca cgtgcttcag     2400

aagaggaaga agcattcaac agaaggagtc aagttaacag ctctgaatga cagcagcctt     2460

gacttgtcta tggacagtga taacagcatg tctgtgcctt cacccaccag tgctatgaag     2520

accagtccat tgaatagttc tggcagctcc cagggcagaa acagtcctgc tccagctgtg     2580

accgcagcat ctgtgaccag catccaggct tctgaggttt ctgtaccgca agcaaattcc     2640

agtgaaagcc cagggggtcc atcgagcgaa agcattcctc aaactgccac acagccagcc     2700

attgccccac caccaaagcc tacagtctcc agagttgtct cctcaacacg actggtaaac     2760

ccatcgccta gaccttcagg aaacacagca acaaaagtcc ctaatcctat agtaggagtc     2820

aagagaacgt ccgcccccaa taaagaagaa gcccctagaa ggaccaaaac agaagaggat     2880

gaaacaagtg aagatgctaa ctgtcttgct ttgagtggac atgataaaac agagacaaag     2940

gaacaagttg atctggagac aagtgcggtt caatcagaaa ctgttccggc atcggcttct     3000

ctgttggcct ctcagaaaac atccagtaca gacctttctg atatccctgc tctccctgca     3060

aatcctattc ctgttatcaa gaactcaata aaactgagac tgaatcgggg atcaggccct     3120

cgcccactgc tcgcaatcca ccctactgaa gcaaggcaca agcaaaaaat tgtggctcct     3180

gtgaagcaga cgctgaactt tgatctgctg aagctcgctg gcgacgtgga gtcgaaccct     3240

ggccctgcca gcctggacaa cctggtggcc agataccagc ggtgcttcaa cgaccagagc     3300

ctgaagaaca gcaccatcga gctggaaatc cggttccagc agatcaactt cctgctgttc     3360

aagaccgtgt acgaggccct ggtcgcccag gaaatcccca gcaccatcag ccacagcatc     3420

cggtgcatca agaaggtgca ccacgagaac cactgccggg agaagatcct gcccagcgag     3480

aacctgtact tcaagaaaca gcccctgatg ttcttcaagt tcagcgagcc cgccagcctg     3540

ggctgtaaag tgtccctggc catcgagcag cccatccgga agttcatcct ggacagcagc     3600

gtgctggtcc ggctgaagaa ccggaccacc ttccgggtgt ccgagctgtg gaagatcgag     3660

ctgaccatcg tgaagcagct gatgggcagc gaggtgtcag ccaagctggc cgccttcaag     3720

accctgctgt tcgacacccc cgagcagcag accaccaaga acatgatgac cctgatcaac     3780

cccgacgacg agtacctgta cgagatcgag atcgagtaca ccggcaagcc tgagagcctg     3840

acagccgccg acgtgatcaa gatcaagaac accgtgctga cactgatcag ccccaaccac     3900

ctgatgctga ccgcctacca ccaggccatc gagtttatcg ccagccacat cctgagcagc     3960

gagatcctgc tggcccggat caagagcggc aagtggggcc tgaagagact gctgccccag     4020

gtcaagtcca tgaccaaggc cgactacatg aagttctacc cccccgtggg ctactacgtg     4080

accgacaagg ccgacggcat ccggggcatt gccgtgatcc aggacaccca gatctacgtg     4140

gtggccgacc agctgtacag cctgggcacc accggcatcg agcccctgaa gcccaccatc     4200

ctggacggcg agttcatgcc cgagaagaaa gagttctacg gctttgacgt gatcatgtac     4260

gagggcaacc tgctgaccca gcagggcttc gagacacgga tcgagagcct gagcaagggc     4320

atcaaggtgc tgcaggcctt caacatcaag gccgagatga agcccttcat cagcctgacc     4380

tccgccgacc ccaacgtgct gctgaagaat ttcgagagca tcttcaagaa gaaaacccgg     4440

ccctacagca tcgacggcat catcctggtg gagcccggca acagctacct gaacaccaac     4500

accttcaagt ggaagcccac ctgggacaac accctggact ttctggtccg gaagtgcccc     4560

gagtccctga acgtgcccga gtacgccccc aagaagggct tcagcctgca tctgctgttc     4620

gtgggcatca gcggcgagct gtttaagaag ctggccctga actggtgccc cggctacacc     4680

aagctgttcc ccgtgaccca gcggaaccag aactacttcc ccgtgcagtt ccagcccagc     4740

gacttccccc tggccttcct gtactaccac cccgacacca gcagcttcag caacatcgat     4800

ggcaaggtgc tggaaatgcg gtgcctgaag cgggagatca actacgtgcg ctgggagatc     4860

gtgaagatcc gggaggaccg gcagcaggat ctgaaaaccg gcggctactt cggcaacgac     4920

ttcaagaccg ccgagctgac ctggctgaac tacatggacc ccttcagctt cgaggaactg     4980

gccaagggac ccagcggcat gtacttcgct ggcgccaaga ccggcatcta cagagcccag     5040

accgccctga tcagcttcat caagcaggaa atcatccaga agatcagcca ccagagctgg     5100

gtgatcgacc tgggcatcgg caagggccag gacctgggca gatacctgga cgccggcgtg     5160

agacacctgg tcggcatcga taaggaccag acagccctgg ccgagctggt gtaccggaag     5220

ttctcccacg ccaccaccag acagcacaag cacgccacca acatctacgt gctgcaccag     5280

gatctggccg agcctgccaa agaaatcagc gagaaagtgc accagatcta tggcttcccc     5340

aaagagggcg ccagcagcat cgtgtccaac ctgttcatcc actacctgat gaagaacacc     5400

cagcaggtcg agaacctggc tgtgctgtgc cacaagctgc tgcagcctgg cggcatggtc     5460

tggttcacca ccatgctggg cgaacaggtg ctggaactgc tgcacgagaa ccggatcgaa     5520

ctgaacgaag tgtgggaggc ccgggagaac gaggtggtca agttcgccat caagcggctg     5580

ttcaaagagg acatcctgca ggaaaccggc caggaaatcg gcgtcctgct gcccttcagc     5640

aacggcgact tctacaatga gtacctggtc aacaccgcct ttctgatcaa gattttcaag     5700

caccatggct ttagcctcgt gcagaagcag agcttcaagg actggatccc cgagttccag     5760

aacttcagca agagcctgta caagatcctg accgaggccg acaagacctg gaccagcctg     5820

ttcggcttca tctgcctgcg gaagaacgga ggcgggggaa gtggaggggg cggcagtcag     5880

gacctgcacg ccatccagct gcagctcgaa gaggaaatgt tcaacggcgg catcagaaga     5940

ttcgaggccg accagcagag acagatcgcc tctggcaacg agagcgacac cgcctggaat     6000

agaaggctgc tgtctgagct gatcgcccct atggccgaag gcatccaggc ctacaaagag     6060

gaatacgagg gcaagagagg cagagcccct agagccctgg ccttcatcaa ctgtgtgggc     6120

aatgaggtgg ccgcctacat caccatgaag atcgtgatgg acatgctgaa caccgacgtg     6180

accctgcagg ccattgccat gaacgtggcc gacagaatcg aggaccaggt ccgattcagc     6240

aagctggaag gacacgccgc caagtacttc gagaaagtga agaagtccct gaaggccagc     6300

aagaccaaga gctacagaca cgcccacaac gtggccgtgg tggccgaaaa atctgtggcc     6360

gatagggacg ccgacttctc tagatgggag gcctggccta aggacaccct gctgcagatc     6420

ggcatgaccc tgctggaaat cctggaaaac agcgtgttct tcaacggcca gcccgtgttc     6480

ctgagaaccc tgaggacaaa tggcggcaag cacggcgtgt actacctgca gacatctgag     6540

cacgtgggcg agtggatcac cgccttcaaa gaacatgtgg cccagctgag ccctgcctat     6600

gccccttgtg tgatccctcc tagaccctgg gtgtcccctt tcaatggcgg ctttcacacc     6660

gagaaggtgg ccagcagaat cagactggtc aagggcaacc gggaacacgt gcggaagctg     6720

accaagaaac agatgcccgc cgtgtacaag gccgtgaatg ctctgcaggc caccaagtgg     6780

caggtcaaca aagaggtgct gcaggtcgtc gaggacgtga tcagactgga tctgggctac     6840

ggcgtgccaa gctttaagcc cctgatcgac agagagaaca agcccgccaa ccctgtgccc     6900

ctggaatttc agcacctgag aggccgcgag ctgaaagaga tgctgacacc tgaacagtgg     6960

caggccttta tcaattggaa gggcgagtgc accaagctgt acaccgccga gacaaagagg     7020

ggctctaagt ctgccgccac agtgcgaatg gtcggacagg ccagaaagta cagccagttc     7080

gacgccatct acttcgtgta cgccctggac agccggtcta gagtgtatgc ccagagcagc     7140

acactgagcc cccagtctaa cgatctggga aaggccctgc tgagattcac cgagggccag     7200

agactggatt ctgccgaagc cctgaagtgg ttcctggtca acggcgccaa caactggggc     7260

tgggacaaga aaaccttcga tgtgcggacc gccaacgtgc tggatagcga gttccaggac     7320

atgtgcagag atatcgccgc cgaccctctg acctttaccc agtgggtcaa cgccgatagc     7380

ccctatggat tcctggcctg gtgcttcgag tacgccagat acctggacgc cctggatgag     7440

ggaacccagg atcagttcat gacccatctg cccgtgcacc aggatggctc ttgttctggc     7500

atccagcact acagcgccat gctgagcgat gccgtgggag ccaaagccgt gaacctgaag     7560

cctagcgaca gcccccagga tatctatggc gctgtggccc aggtggtcat ccagaaaaac     7620

tacgcctaca tgaacgccga ggacgccgag acattcacaa gcggaagcgt gacactgaca     7680

ggcgccgagc tgagatctat ggcctctgcc tgggacatga tcggcatcac acggggcctg     7740

accaaaaagc ctgtgatgac actgccctac ggcagcacca gactgacctg tagagaaagc     7800

gtgatcgact acatcgtgga cctggaagag aaagaggccc agagagccat tgccgagggc     7860

agaacagcca atcctgtgca ccccttcgac aacgaccgga aggatagcct gacacctagc     7920

gccgcctaca actacatgac cgccctgatc tggcccagca tctctgaagt ggtcaaggcc     7980

cctatcgtgg ccatgaagat gatcagacag ctggccagat tcgccgccaa gagaaatgag     8040

ggcctggaat accctctgcc caccggcttt atcctgcagc agaaaatcat ggccaccgac     8100

atgctgcggg tgtccacatg tctgatgggc gagatcaaga tgagcctgca gatcgagaca     8160

gacgtggtgg acgagacagc catgatggga gccgccgctc ctaattttgt gcacggacac     8220

gatgccagcc acctgatcct gaccgtgtgc gatctggtgg acaagggcat cactagcgtg     8280

gccgtgatcc acgatagctt tggaacacac gccggcagaa ccgccgacct gagagattct     8340

ctgcgggaag agatggtcaa gatgtaccag aaccacaacg ccctgcagaa cctgctggac     8400

gtgcacgaag aaagatggct ggtggacacc ggcatccagg tgccagaaca gggagagttc     8460

gacctgaacg agatcctggt gtccgactac tgcttcgcct ga                        8502


<210>  26
<211>  2833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pC3P3-G3d plasmid

<400>  26

Met Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val Cys 
1               5                   10                  15      


Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln Leu 
            20                  25                  30          


Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu Tyr 
        35                  40                  45              


Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro Pro 
    50                  55                  60                  


Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala Met 
65                  70                  75                  80  


Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg Glu 
                85                  90                  95      


Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile Asp 
            100                 105                 110         


Trp Lys Asp Ala Asp Pro Asn Thr Val Ser Ser Phe Gln Val Asp Cys 
        115                 120                 125             


Phe Leu Trp His Val Arg Lys Arg Val Ala Asp Gln Glu Leu Gly Asp 
    130                 135                 140                 


Ala Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly 
145                 150                 155                 160 


Arg Gly Ser Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr Arg Ala Gly 
                165                 170                 175     


Lys Gln Ile Val Glu Arg Ile Leu Lys Glu Glu Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Arg Met Ala Gln Leu Glu Ala Lys Val Glu 
        195                 200                 205             


Glu Leu Leu Ser Lys Asn Trp Asn Leu Glu Asn Glu Val Ala Arg Leu 
    210                 215                 220                 


Lys Lys Leu Val Gly Glu Arg Gly Ser Gly Pro Arg Pro Leu Leu Ala 
225                 230                 235                 240 


Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val 
                245                 250                 255     


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
            260                 265                 270         


Ser Asn Pro Gly Pro Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala 
        275                 280                 285             


Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Pro Phe Pro Val Thr Thr 
    290                 295                 300                 


Gln Gly Ser Gln Gln Thr Gln Pro Pro Gln Arg His Tyr Gly Ile Thr 
305                 310                 315                 320 


Ser Pro Ile Ser Leu Ala Ala Pro Lys Glu Thr Asp Cys Leu Leu Thr 
                325                 330                 335     


Gln Lys Leu Ile Glu Thr Leu Lys Pro Phe Gly Val Phe Glu Glu Glu 
            340                 345                 350         


Glu Glu Leu Gln Arg Arg Ile Leu Ile Leu Gly Lys Leu Asn Asn Leu 
        355                 360                 365             


Val Lys Glu Trp Ile Arg Glu Ile Ser Glu Ser Lys Asn Leu Pro Gln 
    370                 375                 380                 


Ser Val Ile Glu Asn Val Gly Gly Lys Ile Phe Thr Phe Gly Ser Tyr 
385                 390                 395                 400 


Arg Leu Gly Val His Thr Lys Gly Ala Asp Ile Asp Ala Leu Cys Val 
                405                 410                 415     


Ala Pro Arg His Val Asp Arg Ser Asp Phe Phe Thr Ser Phe Tyr Asp 
            420                 425                 430         


Lys Leu Lys Leu Gln Glu Glu Val Lys Asp Leu Arg Ala Val Glu Glu 
        435                 440                 445             


Ala Phe Val Pro Val Ile Lys Leu Cys Phe Asp Gly Ile Glu Ile Asp 
    450                 455                 460                 


Ile Leu Phe Ala Arg Leu Ala Leu Gln Thr Ile Pro Glu Asp Leu Asp 
465                 470                 475                 480 


Leu Arg Asp Asp Ser Leu Leu Lys Asn Leu Asp Ile Arg Cys Ile Arg 
                485                 490                 495     


Ser Leu Asn Gly Cys Arg Val Thr Asp Glu Ile Leu His Leu Val Pro 
            500                 505                 510         


Asn Ile Asp Asn Phe Arg Leu Thr Leu Arg Ala Ile Lys Leu Trp Ala 
        515                 520                 525             


Lys Arg His Asn Ile Tyr Ser Asn Ile Leu Gly Phe Leu Gly Gly Val 
    530                 535                 540                 


Ser Trp Ala Met Leu Val Ala Arg Thr Cys Gln Leu Tyr Pro Asn Ala 
545                 550                 555                 560 


Ile Ala Ser Thr Leu Val His Lys Phe Phe Leu Val Phe Ser Lys Trp 
                565                 570                 575     


Glu Trp Pro Asn Pro Val Leu Leu Lys Gln Pro Glu Glu Cys Asn Leu 
            580                 585                 590         


Asn Leu Pro Val Trp Asp Pro Arg Val Asn Pro Ser Asp Arg Tyr His 
        595                 600                 605             


Leu Met Pro Ile Ile Thr Pro Ala Tyr Pro Gln Gln Asn Ser Thr Tyr 
    610                 615                 620                 


Asn Val Ser Val Ser Thr Arg Met Val Met Val Glu Glu Phe Lys Gln 
625                 630                 635                 640 


Gly Leu Ala Ile Thr Asp Glu Ile Leu Leu Ser Lys Ala Glu Trp Ser 
                645                 650                 655     


Lys Leu Phe Glu Ala Pro Asn Phe Phe Gln Lys Tyr Lys His Tyr Ile 
            660                 665                 670         


Val Leu Leu Ala Ser Ala Pro Thr Glu Lys Gln Arg Leu Glu Trp Val 
        675                 680                 685             


Gly Leu Val Glu Ser Lys Ile Arg Ile Leu Val Gly Ser Leu Glu Lys 
    690                 695                 700                 


Asn Glu Phe Ile Thr Leu Ala His Val Asn Pro Gln Ser Phe Pro Ala 
705                 710                 715                 720 


Pro Lys Glu Ser Pro Asp Arg Glu Glu Phe Arg Thr Met Trp Val Ile 
                725                 730                 735     


Gly Leu Val Phe Lys Lys Thr Glu Asn Ser Glu Asn Leu Ser Val Asp 
            740                 745                 750         


Leu Thr Tyr Asp Ile Gln Ser Phe Thr Asp Thr Val Tyr Arg Gln Ala 
        755                 760                 765             


Ile Asn Ser Lys Met Phe Glu Leu Asp Met Lys Ile Ala Ala Met His 
    770                 775                 780                 


Val Lys Arg Lys Gln Leu His Gln Leu Leu Pro Ser His Val Leu Gln 
785                 790                 795                 800 


Lys Arg Lys Lys His Ser Thr Glu Gly Val Lys Leu Thr Ala Leu Asn 
                805                 810                 815     


Asp Ser Ser Leu Asp Leu Ser Met Asp Ser Asp Asn Ser Met Ser Val 
            820                 825                 830         


Pro Ser Pro Thr Ser Ala Met Lys Thr Ser Pro Leu Asn Ser Ser Gly 
        835                 840                 845             


Ser Ser Gln Gly Arg Asn Ser Pro Ala Pro Ala Val Thr Ala Ala Ser 
    850                 855                 860                 


Val Thr Ser Ile Gln Ala Ser Glu Val Ser Val Pro Gln Ala Asn Ser 
865                 870                 875                 880 


Ser Glu Ser Pro Gly Gly Pro Ser Ser Glu Ser Ile Pro Gln Thr Ala 
                885                 890                 895     


Thr Gln Pro Ala Ile Ala Pro Pro Pro Lys Pro Thr Val Ser Arg Val 
            900                 905                 910         


Val Ser Ser Thr Arg Leu Val Asn Pro Ser Pro Arg Pro Ser Gly Asn 
        915                 920                 925             


Thr Ala Thr Lys Val Pro Asn Pro Ile Val Gly Val Lys Arg Thr Ser 
    930                 935                 940                 


Ala Pro Asn Lys Glu Glu Ala Pro Arg Arg Thr Lys Thr Glu Glu Asp 
945                 950                 955                 960 


Glu Thr Ser Glu Asp Ala Asn Cys Leu Ala Leu Ser Gly His Asp Lys 
                965                 970                 975     


Thr Glu Thr Lys Glu Gln Val Asp Leu Glu Thr Ser Ala Val Gln Ser 
            980                 985                 990         


Glu Thr Val Pro Ala Ser Ala Ser  Leu Leu Ala Ser Gln  Lys Thr Ser 
        995                 1000                 1005             


Ser Thr  Asp Leu Ser Asp Ile  Pro Ala Leu Pro Ala  Asn Pro Ile 
    1010                 1015                 1020             


Pro Val  Ile Lys Asn Ser Ile  Lys Leu Arg Leu Asn  Arg Gly Ser 
    1025                 1030                 1035             


Gly Pro  Arg Pro Leu Leu Ala  Ile His Pro Thr Glu  Ala Arg His 
    1040                 1045                 1050             


Lys Gln  Lys Ile Val Ala Pro  Val Lys Gln Thr Leu  Asn Phe Asp 
    1055                 1060                 1065             


Leu Leu  Lys Leu Ala Gly Asp  Val Glu Ser Asn Pro  Gly Pro Ala 
    1070                 1075                 1080             


Ser Leu  Asp Asn Leu Val Ala  Arg Tyr Gln Arg Cys  Phe Asn Asp 
    1085                 1090                 1095             


Gln Ser  Leu Lys Asn Ser Thr  Ile Glu Leu Glu Ile  Arg Phe Gln 
    1100                 1105                 1110             


Gln Ile  Asn Phe Leu Leu Phe  Lys Thr Val Tyr Glu  Ala Leu Val 
    1115                 1120                 1125             


Ala Gln  Glu Ile Pro Ser Thr  Ile Ser His Ser Ile  Arg Cys Ile 
    1130                 1135                 1140             


Lys Lys  Val His His Glu Asn  His Cys Arg Glu Lys  Ile Leu Pro 
    1145                 1150                 1155             


Ser Glu  Asn Leu Tyr Phe Lys  Lys Gln Pro Leu Met  Phe Phe Lys 
    1160                 1165                 1170             


Phe Ser  Glu Pro Ala Ser Leu  Gly Cys Lys Val Ser  Leu Ala Ile 
    1175                 1180                 1185             


Glu Gln  Pro Ile Arg Lys Phe  Ile Leu Asp Ser Ser  Val Leu Val 
    1190                 1195                 1200             


Arg Leu  Lys Asn Arg Thr Thr  Phe Arg Val Ser Glu  Leu Trp Lys 
    1205                 1210                 1215             


Ile Glu  Leu Thr Ile Val Lys  Gln Leu Met Gly Ser  Glu Val Ser 
    1220                 1225                 1230             


Ala Lys  Leu Ala Ala Phe Lys  Thr Leu Leu Phe Asp  Thr Pro Glu 
    1235                 1240                 1245             


Gln Gln  Thr Thr Lys Asn Met  Met Thr Leu Ile Asn  Pro Asp Asp 
    1250                 1255                 1260             


Glu Tyr  Leu Tyr Glu Ile Glu  Ile Glu Tyr Thr Gly  Lys Pro Glu 
    1265                 1270                 1275             


Ser Leu  Thr Ala Ala Asp Val  Ile Lys Ile Lys Asn  Thr Val Leu 
    1280                 1285                 1290             


Thr Leu  Ile Ser Pro Asn His  Leu Met Leu Thr Ala  Tyr His Gln 
    1295                 1300                 1305             


Ala Ile  Glu Phe Ile Ala Ser  His Ile Leu Ser Ser  Glu Ile Leu 
    1310                 1315                 1320             


Leu Ala  Arg Ile Lys Ser Gly  Lys Trp Gly Leu Lys  Arg Leu Leu 
    1325                 1330                 1335             


Pro Gln  Val Lys Ser Met Thr  Lys Ala Asp Tyr Met  Lys Phe Tyr 
    1340                 1345                 1350             


Pro Pro  Val Gly Tyr Tyr Val  Thr Asp Lys Ala Asp  Gly Ile Arg 
    1355                 1360                 1365             


Gly Ile  Ala Val Ile Gln Asp  Thr Gln Ile Tyr Val  Val Ala Asp 
    1370                 1375                 1380             


Gln Leu  Tyr Ser Leu Gly Thr  Thr Gly Ile Glu Pro  Leu Lys Pro 
    1385                 1390                 1395             


Thr Ile  Leu Asp Gly Glu Phe  Met Pro Glu Lys Lys  Glu Phe Tyr 
    1400                 1405                 1410             


Gly Phe  Asp Val Ile Met Tyr  Glu Gly Asn Leu Leu  Thr Gln Gln 
    1415                 1420                 1425             


Gly Phe  Glu Thr Arg Ile Glu  Ser Leu Ser Lys Gly  Ile Lys Val 
    1430                 1435                 1440             


Leu Gln  Ala Phe Asn Ile Lys  Ala Glu Met Lys Pro  Phe Ile Ser 
    1445                 1450                 1455             


Leu Thr  Ser Ala Asp Pro Asn  Val Leu Leu Lys Asn  Phe Glu Ser 
    1460                 1465                 1470             


Ile Phe  Lys Lys Lys Thr Arg  Pro Tyr Ser Ile Asp  Gly Ile Ile 
    1475                 1480                 1485             


Leu Val  Glu Pro Gly Asn Ser  Tyr Leu Asn Thr Asn  Thr Phe Lys 
    1490                 1495                 1500             


Trp Lys  Pro Thr Trp Asp Asn  Thr Leu Asp Phe Leu  Val Arg Lys 
    1505                 1510                 1515             


Cys Pro  Glu Ser Leu Asn Val  Pro Glu Tyr Ala Pro  Lys Lys Gly 
    1520                 1525                 1530             


Phe Ser  Leu His Leu Leu Phe  Val Gly Ile Ser Gly  Glu Leu Phe 
    1535                 1540                 1545             


Lys Lys  Leu Ala Leu Asn Trp  Cys Pro Gly Tyr Thr  Lys Leu Phe 
    1550                 1555                 1560             


Pro Val  Thr Gln Arg Asn Gln  Asn Tyr Phe Pro Val  Gln Phe Gln 
    1565                 1570                 1575             


Pro Ser  Asp Phe Pro Leu Ala  Phe Leu Tyr Tyr His  Pro Asp Thr 
    1580                 1585                 1590             


Ser Ser  Phe Ser Asn Ile Asp  Gly Lys Val Leu Glu  Met Arg Cys 
    1595                 1600                 1605             


Leu Lys  Arg Glu Ile Asn Tyr  Val Arg Trp Glu Ile  Val Lys Ile 
    1610                 1615                 1620             


Arg Glu  Asp Arg Gln Gln Asp  Leu Lys Thr Gly Gly  Tyr Phe Gly 
    1625                 1630                 1635             


Asn Asp  Phe Lys Thr Ala Glu  Leu Thr Trp Leu Asn  Tyr Met Asp 
    1640                 1645                 1650             


Pro Phe  Ser Phe Glu Glu Leu  Ala Lys Gly Pro Ser  Gly Met Tyr 
    1655                 1660                 1665             


Phe Ala  Gly Ala Lys Thr Gly  Ile Tyr Arg Ala Gln  Thr Ala Leu 
    1670                 1675                 1680             


Ile Ser  Phe Ile Lys Gln Glu  Ile Ile Gln Lys Ile  Ser His Gln 
    1685                 1690                 1695             


Ser Trp  Val Ile Asp Leu Gly  Ile Gly Lys Gly Gln  Asp Leu Gly 
    1700                 1705                 1710             


Arg Tyr  Leu Asp Ala Gly Val  Arg His Leu Val Gly  Ile Asp Lys 
    1715                 1720                 1725             


Asp Gln  Thr Ala Leu Ala Glu  Leu Val Tyr Arg Lys  Phe Ser His 
    1730                 1735                 1740             


Ala Thr  Thr Arg Gln His Lys  His Ala Thr Asn Ile  Tyr Val Leu 
    1745                 1750                 1755             


His Gln  Asp Leu Ala Glu Pro  Ala Lys Glu Ile Ser  Glu Lys Val 
    1760                 1765                 1770             


His Gln  Ile Tyr Gly Phe Pro  Lys Glu Gly Ala Ser  Ser Ile Val 
    1775                 1780                 1785             


Ser Asn  Leu Phe Ile His Tyr  Leu Met Lys Asn Thr  Gln Gln Val 
    1790                 1795                 1800             


Glu Asn  Leu Ala Val Leu Cys  His Lys Leu Leu Gln  Pro Gly Gly 
    1805                 1810                 1815             


Met Val  Trp Phe Thr Thr Met  Leu Gly Glu Gln Val  Leu Glu Leu 
    1820                 1825                 1830             


Leu His  Glu Asn Arg Ile Glu  Leu Asn Glu Val Trp  Glu Ala Arg 
    1835                 1840                 1845             


Glu Asn  Glu Val Val Lys Phe  Ala Ile Lys Arg Leu  Phe Lys Glu 
    1850                 1855                 1860             


Asp Ile  Leu Gln Glu Thr Gly  Gln Glu Ile Gly Val  Leu Leu Pro 
    1865                 1870                 1875             


Phe Ser  Asn Gly Asp Phe Tyr  Asn Glu Tyr Leu Val  Asn Thr Ala 
    1880                 1885                 1890             


Phe Leu  Ile Lys Ile Phe Lys  His His Gly Phe Ser  Leu Val Gln 
    1895                 1900                 1905             


Lys Gln  Ser Phe Lys Asp Trp  Ile Pro Glu Phe Gln  Asn Phe Ser 
    1910                 1915                 1920             


Lys Ser  Leu Tyr Lys Ile Leu  Thr Glu Ala Asp Lys  Thr Trp Thr 
    1925                 1930                 1935             


Ser Leu  Phe Gly Phe Ile Cys  Leu Arg Lys Asn Gly  Gly Gly Gly 
    1940                 1945                 1950             


Ser Gly  Gly Gly Gly Ser Gln  Asp Leu His Ala Ile  Gln Leu Gln 
    1955                 1960                 1965             


Leu Glu  Glu Glu Met Phe Asn  Gly Gly Ile Arg Arg  Phe Glu Ala 
    1970                 1975                 1980             


Asp Gln  Gln Arg Gln Ile Ala  Ser Gly Asn Glu Ser  Asp Thr Ala 
    1985                 1990                 1995             


Trp Asn  Arg Arg Leu Leu Ser  Glu Leu Ile Ala Pro  Met Ala Glu 
    2000                 2005                 2010             


Gly Ile  Gln Ala Tyr Lys Glu  Glu Tyr Glu Gly Lys  Arg Gly Arg 
    2015                 2020                 2025             


Ala Pro  Arg Ala Leu Ala Phe  Ile Asn Cys Val Gly  Asn Glu Val 
    2030                 2035                 2040             


Ala Ala  Tyr Ile Thr Met Lys  Ile Val Met Asp Met  Leu Asn Thr 
    2045                 2050                 2055             


Asp Val  Thr Leu Gln Ala Ile  Ala Met Asn Val Ala  Asp Arg Ile 
    2060                 2065                 2070             


Glu Asp  Gln Val Arg Phe Ser  Lys Leu Glu Gly His  Ala Ala Lys 
    2075                 2080                 2085             


Tyr Phe  Glu Lys Val Lys Lys  Ser Leu Lys Ala Ser  Lys Thr Lys 
    2090                 2095                 2100             


Ser Tyr  Arg His Ala His Asn  Val Ala Val Val Ala  Glu Lys Ser 
    2105                 2110                 2115             


Val Ala  Asp Arg Asp Ala Asp  Phe Ser Arg Trp Glu  Ala Trp Pro 
    2120                 2125                 2130             


Lys Asp  Thr Leu Leu Gln Ile  Gly Met Thr Leu Leu  Glu Ile Leu 
    2135                 2140                 2145             


Glu Asn  Ser Val Phe Phe Asn  Gly Gln Pro Val Phe  Leu Arg Thr 
    2150                 2155                 2160             


Leu Arg  Thr Asn Gly Gly Lys  His Gly Val Tyr Tyr  Leu Gln Thr 
    2165                 2170                 2175             


Ser Glu  His Val Gly Glu Trp  Ile Thr Ala Phe Lys  Glu His Val 
    2180                 2185                 2190             


Ala Gln  Leu Ser Pro Ala Tyr  Ala Pro Cys Val Ile  Pro Pro Arg 
    2195                 2200                 2205             


Pro Trp  Val Ser Pro Phe Asn  Gly Gly Phe His Thr  Glu Lys Val 
    2210                 2215                 2220             


Ala Ser  Arg Ile Arg Leu Val  Lys Gly Asn Arg Glu  His Val Arg 
    2225                 2230                 2235             


Lys Leu  Thr Lys Lys Gln Met  Pro Ala Val Tyr Lys  Ala Val Asn 
    2240                 2245                 2250             


Ala Leu  Gln Ala Thr Lys Trp  Gln Val Asn Lys Glu  Val Leu Gln 
    2255                 2260                 2265             


Val Val  Glu Asp Val Ile Arg  Leu Asp Leu Gly Tyr  Gly Val Pro 
    2270                 2275                 2280             


Ser Phe  Lys Pro Leu Ile Asp  Arg Glu Asn Lys Pro  Ala Asn Pro 
    2285                 2290                 2295             


Val Pro  Leu Glu Phe Gln His  Leu Arg Gly Arg Glu  Leu Lys Glu 
    2300                 2305                 2310             


Met Leu  Thr Pro Glu Gln Trp  Gln Ala Phe Ile Asn  Trp Lys Gly 
    2315                 2320                 2325             


Glu Cys  Thr Lys Leu Tyr Thr  Ala Glu Thr Lys Arg  Gly Ser Lys 
    2330                 2335                 2340             


Ser Ala  Ala Thr Val Arg Met  Val Gly Gln Ala Arg  Lys Tyr Ser 
    2345                 2350                 2355             


Gln Phe  Asp Ala Ile Tyr Phe  Val Tyr Ala Leu Asp  Ser Arg Ser 
    2360                 2365                 2370             


Arg Val  Tyr Ala Gln Ser Ser  Thr Leu Ser Pro Gln  Ser Asn Asp 
    2375                 2380                 2385             


Leu Gly  Lys Ala Leu Leu Arg  Phe Thr Glu Gly Gln  Arg Leu Asp 
    2390                 2395                 2400             


Ser Ala  Glu Ala Leu Lys Trp  Phe Leu Val Asn Gly  Ala Asn Asn 
    2405                 2410                 2415             


Trp Gly  Trp Asp Lys Lys Thr  Phe Asp Val Arg Thr  Ala Asn Val 
    2420                 2425                 2430             


Leu Asp  Ser Glu Phe Gln Asp  Met Cys Arg Asp Ile  Ala Ala Asp 
    2435                 2440                 2445             


Pro Leu  Thr Phe Thr Gln Trp  Val Asn Ala Asp Ser  Pro Tyr Gly 
    2450                 2455                 2460             


Phe Leu  Ala Trp Cys Phe Glu  Tyr Ala Arg Tyr Leu  Asp Ala Leu 
    2465                 2470                 2475             


Asp Glu  Gly Thr Gln Asp Gln  Phe Met Thr His Leu  Pro Val His 
    2480                 2485                 2490             


Gln Asp  Gly Ser Cys Ser Gly  Ile Gln His Tyr Ser  Ala Met Leu 
    2495                 2500                 2505             


Ser Asp  Ala Val Gly Ala Lys  Ala Val Asn Leu Lys  Pro Ser Asp 
    2510                 2515                 2520             


Ser Pro  Gln Asp Ile Tyr Gly  Ala Val Ala Gln Val  Val Ile Gln 
    2525                 2530                 2535             


Lys Asn  Tyr Ala Tyr Met Asn  Ala Glu Asp Ala Glu  Thr Phe Thr 
    2540                 2545                 2550             


Ser Gly  Ser Val Thr Leu Thr  Gly Ala Glu Leu Arg  Ser Met Ala 
    2555                 2560                 2565             


Ser Ala  Trp Asp Met Ile Gly  Ile Thr Arg Gly Leu  Thr Lys Lys 
    2570                 2575                 2580             


Pro Val  Met Thr Leu Pro Tyr  Gly Ser Thr Arg Leu  Thr Cys Arg 
    2585                 2590                 2595             


Glu Ser  Val Ile Asp Tyr Ile  Val Asp Leu Glu Glu  Lys Glu Ala 
    2600                 2605                 2610             


Gln Arg  Ala Ile Ala Glu Gly  Arg Thr Ala Asn Pro  Val His Pro 
    2615                 2620                 2625             


Phe Asp  Asn Asp Arg Lys Asp  Ser Leu Thr Pro Ser  Ala Ala Tyr 
    2630                 2635                 2640             


Asn Tyr  Met Thr Ala Leu Ile  Trp Pro Ser Ile Ser  Glu Val Val 
    2645                 2650                 2655             


Lys Ala  Pro Ile Val Ala Met  Lys Met Ile Arg Gln  Leu Ala Arg 
    2660                 2665                 2670             


Phe Ala  Ala Lys Arg Asn Glu  Gly Leu Glu Tyr Pro  Leu Pro Thr 
    2675                 2680                 2685             


Gly Phe  Ile Leu Gln Gln Lys  Ile Met Ala Thr Asp  Met Leu Arg 
    2690                 2695                 2700             


Val Ser  Thr Cys Leu Met Gly  Glu Ile Lys Met Ser  Leu Gln Ile 
    2705                 2710                 2715             


Glu Thr  Asp Val Val Asp Glu  Thr Ala Met Met Gly  Ala Ala Ala 
    2720                 2725                 2730             


Pro Asn  Phe Val His Gly His  Asp Ala Ser His Leu  Ile Leu Thr 
    2735                 2740                 2745             


Val Cys  Asp Leu Val Asp Lys  Gly Ile Thr Ser Val  Ala Val Ile 
    2750                 2755                 2760             


His Asp  Ser Phe Gly Thr His  Ala Gly Arg Thr Ala  Asp Leu Arg 
    2765                 2770                 2775             


Asp Ser  Leu Arg Glu Glu Met  Val Lys Met Tyr Gln  Asn His Asn 
    2780                 2785                 2790             


Ala Leu  Gln Asn Leu Leu Asp  Val His Glu Glu Arg  Trp Leu Val 
    2795                 2800                 2805             


Asp Thr  Gly Ile Gln Val Pro  Glu Gln Gly Glu Phe  Asp Leu Asn 
    2810                 2815                 2820             


Glu Ile  Leu Val Ser Asp Tyr  Cys Phe Ala 
    2825                 2830             


<210>  27
<211>  8394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pC3P3-G3e plasmid

<400>  27
atgagcaaga tctacatcga cgagagaagc gacgccgaga tcgtgtgcgc cgccatcaag       60

aacatcggca tcgagggcgc caccgccgcc cagctgacca gacagctgaa catggagaag      120

agagaggtga acaaggccct gtacgacctg cagagaagcg ccatggtgta cagcagcgac      180

gacatccccc ccagatggtt catgaccacc gaggccgaca agcccgacgc cgacgccatg      240

gccgacgtga tcatcgacga cgtgagcaga gagaagagca tgagagagga ccacaagagc      300

ttcgacgacg tgatccccgc caagaagatc atcgactgga aggacgccga ccccaataca      360

gtctcctctt ttcaagtgga ctgttttttg tggcatgttc gaaagcgggt tgctgaccaa      420

gagctggggg atgccccgtt tctagaccgg ctacggagag accaaaagag cttgcgtggg      480

agaggcagta ccctgggcct cgacatcgag accgctacac gcgccggcaa gcagatcgtg      540

gaacgcatct taaaagagga gtccggaggc gggggaagtg gagggggcgg cagtaggatg      600

gctcagttgg aggctaaggt agaggaacta ttgtccaaaa attggaatct cgagaacgaa      660

gtagctcgcc tcaagaaact ggtcggcgag cgcggaggag gaggctctgg tggtggcggg      720

agcgatgctc agaccagacg cagagaacgg cgggcagaga agcaggcaca gtggaaggcc      780

gctaatccgt ttccagttac aacgcaggga tcacaacaaa cgcagccacc acagaggcac      840

tatggcatta cctctcctat cagcttagcg gcccccaagg agactgactg cctactcaca      900

cagaagctca tcgagacgct gaagcccttt ggggtttttg aagaagaaga ggaactgcag      960

cgcaggattt taattttggg aaaattaaat aacctggtga aagaatggat tcgagaaatc     1020

agtgaaagca agaatctccc acaatctgta attgaaaatg ttggagggaa gatttttaca     1080

tttggatctt acagactagg agtccacacg aaaggtgctg atattgatgc gttgtgtgtt     1140

gcaccaagac atgttgatcg aagtgacttt ttcacctcat tctatgataa attgaaatta     1200

caagaagaag tgaaagattt aagagctgtt gaagaggcat ttgtaccagt tatcaaactc     1260

tgttttgatg gaatagagat tgatattttg tttgcaagat tagcactgca gactattcca     1320

gaagatttgg acctacgaga tgacagtctg cttaaaaacc tagatataag atgcataaga     1380

agccttaatg gttgcagggt aaccgatgaa attttacatc tagtaccaaa cattgacaac     1440

ttcaggttaa ctctgagagc catcaaactg tgggccaaac ggcacaacat ctattccaat     1500

atattaggtt tcctcggtgg tgtttcctgg gctatgctag tagcaagaac ttgccagctt     1560

tatccaaatg caatagcatc aactcttgta cataaatttt tcttggtatt ttctaaatgg     1620

gaatggccaa atccagtgct attgaaacag cctgaagaat gcaatcttaa tttgcctgtg     1680

tgggacccaa gggtaaaccc cagtgatagg taccatctta tgcctataat tacaccagca     1740

tacccacagc agaactccac gtacaatgtg tccgtttcaa cacggatggt catggttgag     1800

gagtttaaac aaggtcttgc tatcacagat gaaattttgc tgagtaaggc agagtggtcc     1860

aaactttttg aagctccaaa cttctttcag aagtacaagc attatattgt acttctagca     1920

agtgcgccca cggaaaagca gcgtctggaa tgggtgggct tggtggaatc aaaaatccgc     1980

atcctggttg gaagcttgga gaagaatgag tttattacac tggctcatgt gaatccccag     2040

tcatttccag cccccaaaga aagtcctgac agggaagaat ttcgcacaat gtgggtgatt     2100

gggttagtgt ttaaaaaaac tgaaaactct gaaaatctca gtgtcgacct cacctatgat     2160

atccagtctt tcacagacac agtttatagg caagcaataa acagcaaaat gtttgagttg     2220

gatatgaaga ttgcagcaat gcatgtgaag agaaagcaac tccatcagct gctgcctagt     2280

cacgtgcttc agaagaggaa gaagcattca acagaaggag tcaagttaac agctctgaat     2340

gacagcagcc ttgacttgtc tatggacagt gataacagca tgtctgtgcc ttcacccacc     2400

agtgctatga agaccagtcc attgaatagt tctggcagct cccagggcag aaacagtcct     2460

gctccagctg tgaccgcagc atctgtgacc agcatccagg cttctgaggt ttctgtaccg     2520

caagcaaatt ccagtgaaag cccagggggt ccatcgagcg aaagcattcc tcaaactgcc     2580

acacagccag ccattgcccc accaccaaag cctacagtct ccagagttgt ctcctcaaca     2640

cgactggtaa acccatcgcc tagaccttca ggaaacacag caacaaaagt ccctaatcct     2700

atagtaggag tcaagagaac gtccgccccc aataaagaag aagcccctag aaggaccaaa     2760

acagaagagg atgaaacaag tgaagatgct aactgtcttg ctttgagtgg acatgataaa     2820

acagagacaa aggaacaagt tgatctggag acaagtgcgg ttcaatcaga aactgttccg     2880

gcatcggctt ctctgttggc ctctcagaaa acatccagta cagacctttc tgatatccct     2940

gctctccctg caaatcctat tcctgttatc aagaactcaa taaaactgag actgaatcgg     3000

ggatcaggcc ctcgcccact gctcgcaatc caccctactg aagcaaggca caagcaaaaa     3060

attgtggctc ctgtgaagca gacgctgaac tttgatctgc tgaagctcgc tggcgacgtg     3120

gagtcgaacc ctggccctgc cagcctggac aacctggtgg ccagatacca gcggtgcttc     3180

aacgaccaga gcctgaagaa cagcaccatc gagctggaaa tccggttcca gcagatcaac     3240

ttcctgctgt tcaagaccgt gtacgaggcc ctggtcgccc aggaaatccc cagcaccatc     3300

agccacagca tccggtgcat caagaaggtg caccacgaga accactgccg ggagaagatc     3360

ctgcccagcg agaacctgta cttcaagaaa cagcccctga tgttcttcaa gttcagcgag     3420

cccgccagcc tgggctgtaa agtgtccctg gccatcgagc agcccatccg gaagttcatc     3480

ctggacagca gcgtgctggt ccggctgaag aaccggacca ccttccgggt gtccgagctg     3540

tggaagatcg agctgaccat cgtgaagcag ctgatgggca gcgaggtgtc agccaagctg     3600

gccgccttca agaccctgct gttcgacacc cccgagcagc agaccaccaa gaacatgatg     3660

accctgatca accccgacga cgagtacctg tacgagatcg agatcgagta caccggcaag     3720

cctgagagcc tgacagccgc cgacgtgatc aagatcaaga acaccgtgct gacactgatc     3780

agccccaacc acctgatgct gaccgcctac caccaggcca tcgagtttat cgccagccac     3840

atcctgagca gcgagatcct gctggcccgg atcaagagcg gcaagtgggg cctgaagaga     3900

ctgctgcccc aggtcaagtc catgaccaag gccgactaca tgaagttcta cccccccgtg     3960

ggctactacg tgaccgacaa ggccgacggc atccggggca ttgccgtgat ccaggacacc     4020

cagatctacg tggtggccga ccagctgtac agcctgggca ccaccggcat cgagcccctg     4080

aagcccacca tcctggacgg cgagttcatg cccgagaaga aagagttcta cggctttgac     4140

gtgatcatgt acgagggcaa cctgctgacc cagcagggct tcgagacacg gatcgagagc     4200

ctgagcaagg gcatcaaggt gctgcaggcc ttcaacatca aggccgagat gaagcccttc     4260

atcagcctga cctccgccga ccccaacgtg ctgctgaaga atttcgagag catcttcaag     4320

aagaaaaccc ggccctacag catcgacggc atcatcctgg tggagcccgg caacagctac     4380

ctgaacacca acaccttcaa gtggaagccc acctgggaca acaccctgga ctttctggtc     4440

cggaagtgcc ccgagtccct gaacgtgccc gagtacgccc ccaagaaggg cttcagcctg     4500

catctgctgt tcgtgggcat cagcggcgag ctgtttaaga agctggccct gaactggtgc     4560

cccggctaca ccaagctgtt ccccgtgacc cagcggaacc agaactactt ccccgtgcag     4620

ttccagccca gcgacttccc cctggccttc ctgtactacc accccgacac cagcagcttc     4680

agcaacatcg atggcaaggt gctggaaatg cggtgcctga agcgggagat caactacgtg     4740

cgctgggaga tcgtgaagat ccgggaggac cggcagcagg atctgaaaac cggcggctac     4800

ttcggcaacg acttcaagac cgccgagctg acctggctga actacatgga ccccttcagc     4860

ttcgaggaac tggccaaggg acccagcggc atgtacttcg ctggcgccaa gaccggcatc     4920

tacagagccc agaccgccct gatcagcttc atcaagcagg aaatcatcca gaagatcagc     4980

caccagagct gggtgatcga cctgggcatc ggcaagggcc aggacctggg cagatacctg     5040

gacgccggcg tgagacacct ggtcggcatc gataaggacc agacagccct ggccgagctg     5100

gtgtaccgga agttctccca cgccaccacc agacagcaca agcacgccac caacatctac     5160

gtgctgcacc aggatctggc cgagcctgcc aaagaaatca gcgagaaagt gcaccagatc     5220

tatggcttcc ccaaagaggg cgccagcagc atcgtgtcca acctgttcat ccactacctg     5280

atgaagaaca cccagcaggt cgagaacctg gctgtgctgt gccacaagct gctgcagcct     5340

ggcggcatgg tctggttcac caccatgctg ggcgaacagg tgctggaact gctgcacgag     5400

aaccggatcg aactgaacga agtgtgggag gcccgggaga acgaggtggt caagttcgcc     5460

atcaagcggc tgttcaaaga ggacatcctg caggaaaccg gccaggaaat cggcgtcctg     5520

ctgcccttca gcaacggcga cttctacaat gagtacctgg tcaacaccgc ctttctgatc     5580

aagattttca agcaccatgg ctttagcctc gtgcagaagc agagcttcaa ggactggatc     5640

cccgagttcc agaacttcag caagagcctg tacaagatcc tgaccgaggc cgacaagacc     5700

tggaccagcc tgttcggctt catctgcctg cggaagaacg gaggcggggg aagtggaggg     5760

ggcggcagtc aggacctgca cgccatccag ctgcagctcg aagaggaaat gttcaacggc     5820

ggcatcagaa gattcgaggc cgaccagcag agacagatcg cctctggcaa cgagagcgac     5880

accgcctgga atagaaggct gctgtctgag ctgatcgccc ctatggccga aggcatccag     5940

gcctacaaag aggaatacga gggcaagaga ggcagagccc ctagagccct ggccttcatc     6000

aactgtgtgg gcaatgaggt ggccgcctac atcaccatga agatcgtgat ggacatgctg     6060

aacaccgacg tgaccctgca ggccattgcc atgaacgtgg ccgacagaat cgaggaccag     6120

gtccgattca gcaagctgga aggacacgcc gccaagtact tcgagaaagt gaagaagtcc     6180

ctgaaggcca gcaagaccaa gagctacaga cacgcccaca acgtggccgt ggtggccgaa     6240

aaatctgtgg ccgataggga cgccgacttc tctagatggg aggcctggcc taaggacacc     6300

ctgctgcaga tcggcatgac cctgctggaa atcctggaaa acagcgtgtt cttcaacggc     6360

cagcccgtgt tcctgagaac cctgaggaca aatggcggca agcacggcgt gtactacctg     6420

cagacatctg agcacgtggg cgagtggatc accgccttca aagaacatgt ggcccagctg     6480

agccctgcct atgccccttg tgtgatccct cctagaccct gggtgtcccc tttcaatggc     6540

ggctttcaca ccgagaaggt ggccagcaga atcagactgg tcaagggcaa ccgggaacac     6600

gtgcggaagc tgaccaagaa acagatgccc gccgtgtaca aggccgtgaa tgctctgcag     6660

gccaccaagt ggcaggtcaa caaagaggtg ctgcaggtcg tcgaggacgt gatcagactg     6720

gatctgggct acggcgtgcc aagctttaag cccctgatcg acagagagaa caagcccgcc     6780

aaccctgtgc ccctggaatt tcagcacctg agaggccgcg agctgaaaga gatgctgaca     6840

cctgaacagt ggcaggcctt tatcaattgg aagggcgagt gcaccaagct gtacaccgcc     6900

gagacaaaga ggggctctaa gtctgccgcc acagtgcgaa tggtcggaca ggccagaaag     6960

tacagccagt tcgacgccat ctacttcgtg tacgccctgg acagccggtc tagagtgtat     7020

gcccagagca gcacactgag cccccagtct aacgatctgg gaaaggccct gctgagattc     7080

accgagggcc agagactgga ttctgccgaa gccctgaagt ggttcctggt caacggcgcc     7140

aacaactggg gctgggacaa gaaaaccttc gatgtgcgga ccgccaacgt gctggatagc     7200

gagttccagg acatgtgcag agatatcgcc gccgaccctc tgacctttac ccagtgggtc     7260

aacgccgata gcccctatgg attcctggcc tggtgcttcg agtacgccag atacctggac     7320

gccctggatg agggaaccca ggatcagttc atgacccatc tgcccgtgca ccaggatggc     7380

tcttgttctg gcatccagca ctacagcgcc atgctgagcg atgccgtggg agccaaagcc     7440

gtgaacctga agcctagcga cagcccccag gatatctatg gcgctgtggc ccaggtggtc     7500

atccagaaaa actacgccta catgaacgcc gaggacgccg agacattcac aagcggaagc     7560

gtgacactga caggcgccga gctgagatct atggcctctg cctgggacat gatcggcatc     7620

acacggggcc tgaccaaaaa gcctgtgatg acactgccct acggcagcac cagactgacc     7680

tgtagagaaa gcgtgatcga ctacatcgtg gacctggaag agaaagaggc ccagagagcc     7740

attgccgagg gcagaacagc caatcctgtg caccccttcg acaacgaccg gaaggatagc     7800

ctgacaccta gcgccgccta caactacatg accgccctga tctggcccag catctctgaa     7860

gtggtcaagg cccctatcgt ggccatgaag atgatcagac agctggccag attcgccgcc     7920

aagagaaatg agggcctgga ataccctctg cccaccggct ttatcctgca gcagaaaatc     7980

atggccaccg acatgctgcg ggtgtccaca tgtctgatgg gcgagatcaa gatgagcctg     8040

cagatcgaga cagacgtggt ggacgagaca gccatgatgg gagccgccgc tcctaatttt     8100

gtgcacggac acgatgccag ccacctgatc ctgaccgtgt gcgatctggt ggacaagggc     8160

atcactagcg tggccgtgat ccacgatagc tttggaacac acgccggcag aaccgccgac     8220

ctgagagatt ctctgcggga agagatggtc aagatgtacc agaaccacaa cgccctgcag     8280

aacctgctgg acgtgcacga agaaagatgg ctggtggaca ccggcatcca ggtgccagaa     8340

cagggagagt tcgacctgaa cgagatcctg gtgtccgact actgcttcgc ctga           8394


<210>  28
<211>  2797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encocded by pC3P3-G3e plasmid

<400>  28

Met Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val Cys 
1               5                   10                  15      


Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln Leu 
            20                  25                  30          


Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu Tyr 
        35                  40                  45              


Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro Pro 
    50                  55                  60                  


Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala Met 
65                  70                  75                  80  


Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg Glu 
                85                  90                  95      


Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile Asp 
            100                 105                 110         


Trp Lys Asp Ala Asp Pro Asn Thr Val Ser Ser Phe Gln Val Asp Cys 
        115                 120                 125             


Phe Leu Trp His Val Arg Lys Arg Val Ala Asp Gln Glu Leu Gly Asp 
    130                 135                 140                 


Ala Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly 
145                 150                 155                 160 


Arg Gly Ser Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr Arg Ala Gly 
                165                 170                 175     


Lys Gln Ile Val Glu Arg Ile Leu Lys Glu Glu Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Arg Met Ala Gln Leu Glu Ala Lys Val Glu 
        195                 200                 205             


Glu Leu Leu Ser Lys Asn Trp Asn Leu Glu Asn Glu Val Ala Arg Leu 
    210                 215                 220                 


Lys Lys Leu Val Gly Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
                245                 250                 255     


Gln Trp Lys Ala Ala Asn Pro Phe Pro Val Thr Thr Gln Gly Ser Gln 
            260                 265                 270         


Gln Thr Gln Pro Pro Gln Arg His Tyr Gly Ile Thr Ser Pro Ile Ser 
        275                 280                 285             


Leu Ala Ala Pro Lys Glu Thr Asp Cys Leu Leu Thr Gln Lys Leu Ile 
    290                 295                 300                 


Glu Thr Leu Lys Pro Phe Gly Val Phe Glu Glu Glu Glu Glu Leu Gln 
305                 310                 315                 320 


Arg Arg Ile Leu Ile Leu Gly Lys Leu Asn Asn Leu Val Lys Glu Trp 
                325                 330                 335     


Ile Arg Glu Ile Ser Glu Ser Lys Asn Leu Pro Gln Ser Val Ile Glu 
            340                 345                 350         


Asn Val Gly Gly Lys Ile Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val 
        355                 360                 365             


His Thr Lys Gly Ala Asp Ile Asp Ala Leu Cys Val Ala Pro Arg His 
    370                 375                 380                 


Val Asp Arg Ser Asp Phe Phe Thr Ser Phe Tyr Asp Lys Leu Lys Leu 
385                 390                 395                 400 


Gln Glu Glu Val Lys Asp Leu Arg Ala Val Glu Glu Ala Phe Val Pro 
                405                 410                 415     


Val Ile Lys Leu Cys Phe Asp Gly Ile Glu Ile Asp Ile Leu Phe Ala 
            420                 425                 430         


Arg Leu Ala Leu Gln Thr Ile Pro Glu Asp Leu Asp Leu Arg Asp Asp 
        435                 440                 445             


Ser Leu Leu Lys Asn Leu Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly 
    450                 455                 460                 


Cys Arg Val Thr Asp Glu Ile Leu His Leu Val Pro Asn Ile Asp Asn 
465                 470                 475                 480 


Phe Arg Leu Thr Leu Arg Ala Ile Lys Leu Trp Ala Lys Arg His Asn 
                485                 490                 495     


Ile Tyr Ser Asn Ile Leu Gly Phe Leu Gly Gly Val Ser Trp Ala Met 
            500                 505                 510         


Leu Val Ala Arg Thr Cys Gln Leu Tyr Pro Asn Ala Ile Ala Ser Thr 
        515                 520                 525             


Leu Val His Lys Phe Phe Leu Val Phe Ser Lys Trp Glu Trp Pro Asn 
    530                 535                 540                 


Pro Val Leu Leu Lys Gln Pro Glu Glu Cys Asn Leu Asn Leu Pro Val 
545                 550                 555                 560 


Trp Asp Pro Arg Val Asn Pro Ser Asp Arg Tyr His Leu Met Pro Ile 
                565                 570                 575     


Ile Thr Pro Ala Tyr Pro Gln Gln Asn Ser Thr Tyr Asn Val Ser Val 
            580                 585                 590         


Ser Thr Arg Met Val Met Val Glu Glu Phe Lys Gln Gly Leu Ala Ile 
        595                 600                 605             


Thr Asp Glu Ile Leu Leu Ser Lys Ala Glu Trp Ser Lys Leu Phe Glu 
    610                 615                 620                 


Ala Pro Asn Phe Phe Gln Lys Tyr Lys His Tyr Ile Val Leu Leu Ala 
625                 630                 635                 640 


Ser Ala Pro Thr Glu Lys Gln Arg Leu Glu Trp Val Gly Leu Val Glu 
                645                 650                 655     


Ser Lys Ile Arg Ile Leu Val Gly Ser Leu Glu Lys Asn Glu Phe Ile 
            660                 665                 670         


Thr Leu Ala His Val Asn Pro Gln Ser Phe Pro Ala Pro Lys Glu Ser 
        675                 680                 685             


Pro Asp Arg Glu Glu Phe Arg Thr Met Trp Val Ile Gly Leu Val Phe 
    690                 695                 700                 


Lys Lys Thr Glu Asn Ser Glu Asn Leu Ser Val Asp Leu Thr Tyr Asp 
705                 710                 715                 720 


Ile Gln Ser Phe Thr Asp Thr Val Tyr Arg Gln Ala Ile Asn Ser Lys 
                725                 730                 735     


Met Phe Glu Leu Asp Met Lys Ile Ala Ala Met His Val Lys Arg Lys 
            740                 745                 750         


Gln Leu His Gln Leu Leu Pro Ser His Val Leu Gln Lys Arg Lys Lys 
        755                 760                 765             


His Ser Thr Glu Gly Val Lys Leu Thr Ala Leu Asn Asp Ser Ser Leu 
    770                 775                 780                 


Asp Leu Ser Met Asp Ser Asp Asn Ser Met Ser Val Pro Ser Pro Thr 
785                 790                 795                 800 


Ser Ala Met Lys Thr Ser Pro Leu Asn Ser Ser Gly Ser Ser Gln Gly 
                805                 810                 815     


Arg Asn Ser Pro Ala Pro Ala Val Thr Ala Ala Ser Val Thr Ser Ile 
            820                 825                 830         


Gln Ala Ser Glu Val Ser Val Pro Gln Ala Asn Ser Ser Glu Ser Pro 
        835                 840                 845             


Gly Gly Pro Ser Ser Glu Ser Ile Pro Gln Thr Ala Thr Gln Pro Ala 
    850                 855                 860                 


Ile Ala Pro Pro Pro Lys Pro Thr Val Ser Arg Val Val Ser Ser Thr 
865                 870                 875                 880 


Arg Leu Val Asn Pro Ser Pro Arg Pro Ser Gly Asn Thr Ala Thr Lys 
                885                 890                 895     


Val Pro Asn Pro Ile Val Gly Val Lys Arg Thr Ser Ala Pro Asn Lys 
            900                 905                 910         


Glu Glu Ala Pro Arg Arg Thr Lys Thr Glu Glu Asp Glu Thr Ser Glu 
        915                 920                 925             


Asp Ala Asn Cys Leu Ala Leu Ser Gly His Asp Lys Thr Glu Thr Lys 
    930                 935                 940                 


Glu Gln Val Asp Leu Glu Thr Ser Ala Val Gln Ser Glu Thr Val Pro 
945                 950                 955                 960 


Ala Ser Ala Ser Leu Leu Ala Ser Gln Lys Thr Ser Ser Thr Asp Leu 
                965                 970                 975     


Ser Asp Ile Pro Ala Leu Pro Ala Asn Pro Ile Pro Val Ile Lys Asn 
            980                 985                 990         


Ser Ile Lys Leu Arg Leu Asn Arg  Gly Ser Gly Pro Arg  Pro Leu Leu 
        995                 1000                 1005             


Ala Ile  His Pro Thr Glu Ala  Arg His Lys Gln Lys  Ile Val Ala 
    1010                 1015                 1020             


Pro Val  Lys Gln Thr Leu Asn  Phe Asp Leu Leu Lys  Leu Ala Gly 
    1025                 1030                 1035             


Asp Val  Glu Ser Asn Pro Gly  Pro Ala Ser Leu Asp  Asn Leu Val 
    1040                 1045                 1050             


Ala Arg  Tyr Gln Arg Cys Phe  Asn Asp Gln Ser Leu  Lys Asn Ser 
    1055                 1060                 1065             


Thr Ile  Glu Leu Glu Ile Arg  Phe Gln Gln Ile Asn  Phe Leu Leu 
    1070                 1075                 1080             


Phe Lys  Thr Val Tyr Glu Ala  Leu Val Ala Gln Glu  Ile Pro Ser 
    1085                 1090                 1095             


Thr Ile  Ser His Ser Ile Arg  Cys Ile Lys Lys Val  His His Glu 
    1100                 1105                 1110             


Asn His  Cys Arg Glu Lys Ile  Leu Pro Ser Glu Asn  Leu Tyr Phe 
    1115                 1120                 1125             


Lys Lys  Gln Pro Leu Met Phe  Phe Lys Phe Ser Glu  Pro Ala Ser 
    1130                 1135                 1140             


Leu Gly  Cys Lys Val Ser Leu  Ala Ile Glu Gln Pro  Ile Arg Lys 
    1145                 1150                 1155             


Phe Ile  Leu Asp Ser Ser Val  Leu Val Arg Leu Lys  Asn Arg Thr 
    1160                 1165                 1170             


Thr Phe  Arg Val Ser Glu Leu  Trp Lys Ile Glu Leu  Thr Ile Val 
    1175                 1180                 1185             


Lys Gln  Leu Met Gly Ser Glu  Val Ser Ala Lys Leu  Ala Ala Phe 
    1190                 1195                 1200             


Lys Thr  Leu Leu Phe Asp Thr  Pro Glu Gln Gln Thr  Thr Lys Asn 
    1205                 1210                 1215             


Met Met  Thr Leu Ile Asn Pro  Asp Asp Glu Tyr Leu  Tyr Glu Ile 
    1220                 1225                 1230             


Glu Ile  Glu Tyr Thr Gly Lys  Pro Glu Ser Leu Thr  Ala Ala Asp 
    1235                 1240                 1245             


Val Ile  Lys Ile Lys Asn Thr  Val Leu Thr Leu Ile  Ser Pro Asn 
    1250                 1255                 1260             


His Leu  Met Leu Thr Ala Tyr  His Gln Ala Ile Glu  Phe Ile Ala 
    1265                 1270                 1275             


Ser His  Ile Leu Ser Ser Glu  Ile Leu Leu Ala Arg  Ile Lys Ser 
    1280                 1285                 1290             


Gly Lys  Trp Gly Leu Lys Arg  Leu Leu Pro Gln Val  Lys Ser Met 
    1295                 1300                 1305             


Thr Lys  Ala Asp Tyr Met Lys  Phe Tyr Pro Pro Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Val Thr  Asp Lys Ala Asp Gly  Ile Arg Gly Ile Ala  Val Ile Gln 
    1325                 1330                 1335             


Asp Thr  Gln Ile Tyr Val Val  Ala Asp Gln Leu Tyr  Ser Leu Gly 
    1340                 1345                 1350             


Thr Thr  Gly Ile Glu Pro Leu  Lys Pro Thr Ile Leu  Asp Gly Glu 
    1355                 1360                 1365             


Phe Met  Pro Glu Lys Lys Glu  Phe Tyr Gly Phe Asp  Val Ile Met 
    1370                 1375                 1380             


Tyr Glu  Gly Asn Leu Leu Thr  Gln Gln Gly Phe Glu  Thr Arg Ile 
    1385                 1390                 1395             


Glu Ser  Leu Ser Lys Gly Ile  Lys Val Leu Gln Ala  Phe Asn Ile 
    1400                 1405                 1410             


Lys Ala  Glu Met Lys Pro Phe  Ile Ser Leu Thr Ser  Ala Asp Pro 
    1415                 1420                 1425             


Asn Val  Leu Leu Lys Asn Phe  Glu Ser Ile Phe Lys  Lys Lys Thr 
    1430                 1435                 1440             


Arg Pro  Tyr Ser Ile Asp Gly  Ile Ile Leu Val Glu  Pro Gly Asn 
    1445                 1450                 1455             


Ser Tyr  Leu Asn Thr Asn Thr  Phe Lys Trp Lys Pro  Thr Trp Asp 
    1460                 1465                 1470             


Asn Thr  Leu Asp Phe Leu Val  Arg Lys Cys Pro Glu  Ser Leu Asn 
    1475                 1480                 1485             


Val Pro  Glu Tyr Ala Pro Lys  Lys Gly Phe Ser Leu  His Leu Leu 
    1490                 1495                 1500             


Phe Val  Gly Ile Ser Gly Glu  Leu Phe Lys Lys Leu  Ala Leu Asn 
    1505                 1510                 1515             


Trp Cys  Pro Gly Tyr Thr Lys  Leu Phe Pro Val Thr  Gln Arg Asn 
    1520                 1525                 1530             


Gln Asn  Tyr Phe Pro Val Gln  Phe Gln Pro Ser Asp  Phe Pro Leu 
    1535                 1540                 1545             


Ala Phe  Leu Tyr Tyr His Pro  Asp Thr Ser Ser Phe  Ser Asn Ile 
    1550                 1555                 1560             


Asp Gly  Lys Val Leu Glu Met  Arg Cys Leu Lys Arg  Glu Ile Asn 
    1565                 1570                 1575             


Tyr Val  Arg Trp Glu Ile Val  Lys Ile Arg Glu Asp  Arg Gln Gln 
    1580                 1585                 1590             


Asp Leu  Lys Thr Gly Gly Tyr  Phe Gly Asn Asp Phe  Lys Thr Ala 
    1595                 1600                 1605             


Glu Leu  Thr Trp Leu Asn Tyr  Met Asp Pro Phe Ser  Phe Glu Glu 
    1610                 1615                 1620             


Leu Ala  Lys Gly Pro Ser Gly  Met Tyr Phe Ala Gly  Ala Lys Thr 
    1625                 1630                 1635             


Gly Ile  Tyr Arg Ala Gln Thr  Ala Leu Ile Ser Phe  Ile Lys Gln 
    1640                 1645                 1650             


Glu Ile  Ile Gln Lys Ile Ser  His Gln Ser Trp Val  Ile Asp Leu 
    1655                 1660                 1665             


Gly Ile  Gly Lys Gly Gln Asp  Leu Gly Arg Tyr Leu  Asp Ala Gly 
    1670                 1675                 1680             


Val Arg  His Leu Val Gly Ile  Asp Lys Asp Gln Thr  Ala Leu Ala 
    1685                 1690                 1695             


Glu Leu  Val Tyr Arg Lys Phe  Ser His Ala Thr Thr  Arg Gln His 
    1700                 1705                 1710             


Lys His  Ala Thr Asn Ile Tyr  Val Leu His Gln Asp  Leu Ala Glu 
    1715                 1720                 1725             


Pro Ala  Lys Glu Ile Ser Glu  Lys Val His Gln Ile  Tyr Gly Phe 
    1730                 1735                 1740             


Pro Lys  Glu Gly Ala Ser Ser  Ile Val Ser Asn Leu  Phe Ile His 
    1745                 1750                 1755             


Tyr Leu  Met Lys Asn Thr Gln  Gln Val Glu Asn Leu  Ala Val Leu 
    1760                 1765                 1770             


Cys His  Lys Leu Leu Gln Pro  Gly Gly Met Val Trp  Phe Thr Thr 
    1775                 1780                 1785             


Met Leu  Gly Glu Gln Val Leu  Glu Leu Leu His Glu  Asn Arg Ile 
    1790                 1795                 1800             


Glu Leu  Asn Glu Val Trp Glu  Ala Arg Glu Asn Glu  Val Val Lys 
    1805                 1810                 1815             


Phe Ala  Ile Lys Arg Leu Phe  Lys Glu Asp Ile Leu  Gln Glu Thr 
    1820                 1825                 1830             


Gly Gln  Glu Ile Gly Val Leu  Leu Pro Phe Ser Asn  Gly Asp Phe 
    1835                 1840                 1845             


Tyr Asn  Glu Tyr Leu Val Asn  Thr Ala Phe Leu Ile  Lys Ile Phe 
    1850                 1855                 1860             


Lys His  His Gly Phe Ser Leu  Val Gln Lys Gln Ser  Phe Lys Asp 
    1865                 1870                 1875             


Trp Ile  Pro Glu Phe Gln Asn  Phe Ser Lys Ser Leu  Tyr Lys Ile 
    1880                 1885                 1890             


Leu Thr  Glu Ala Asp Lys Thr  Trp Thr Ser Leu Phe  Gly Phe Ile 
    1895                 1900                 1905             


Cys Leu  Arg Lys Asn Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1910                 1915                 1920             


Gln Asp  Leu His Ala Ile Gln  Leu Gln Leu Glu Glu  Glu Met Phe 
    1925                 1930                 1935             


Asn Gly  Gly Ile Arg Arg Phe  Glu Ala Asp Gln Gln  Arg Gln Ile 
    1940                 1945                 1950             


Ala Ser  Gly Asn Glu Ser Asp  Thr Ala Trp Asn Arg  Arg Leu Leu 
    1955                 1960                 1965             


Ser Glu  Leu Ile Ala Pro Met  Ala Glu Gly Ile Gln  Ala Tyr Lys 
    1970                 1975                 1980             


Glu Glu  Tyr Glu Gly Lys Arg  Gly Arg Ala Pro Arg  Ala Leu Ala 
    1985                 1990                 1995             


Phe Ile  Asn Cys Val Gly Asn  Glu Val Ala Ala Tyr  Ile Thr Met 
    2000                 2005                 2010             


Lys Ile  Val Met Asp Met Leu  Asn Thr Asp Val Thr  Leu Gln Ala 
    2015                 2020                 2025             


Ile Ala  Met Asn Val Ala Asp  Arg Ile Glu Asp Gln  Val Arg Phe 
    2030                 2035                 2040             


Ser Lys  Leu Glu Gly His Ala  Ala Lys Tyr Phe Glu  Lys Val Lys 
    2045                 2050                 2055             


Lys Ser  Leu Lys Ala Ser Lys  Thr Lys Ser Tyr Arg  His Ala His 
    2060                 2065                 2070             


Asn Val  Ala Val Val Ala Glu  Lys Ser Val Ala Asp  Arg Asp Ala 
    2075                 2080                 2085             


Asp Phe  Ser Arg Trp Glu Ala  Trp Pro Lys Asp Thr  Leu Leu Gln 
    2090                 2095                 2100             


Ile Gly  Met Thr Leu Leu Glu  Ile Leu Glu Asn Ser  Val Phe Phe 
    2105                 2110                 2115             


Asn Gly  Gln Pro Val Phe Leu  Arg Thr Leu Arg Thr  Asn Gly Gly 
    2120                 2125                 2130             


Lys His  Gly Val Tyr Tyr Leu  Gln Thr Ser Glu His  Val Gly Glu 
    2135                 2140                 2145             


Trp Ile  Thr Ala Phe Lys Glu  His Val Ala Gln Leu  Ser Pro Ala 
    2150                 2155                 2160             


Tyr Ala  Pro Cys Val Ile Pro  Pro Arg Pro Trp Val  Ser Pro Phe 
    2165                 2170                 2175             


Asn Gly  Gly Phe His Thr Glu  Lys Val Ala Ser Arg  Ile Arg Leu 
    2180                 2185                 2190             


Val Lys  Gly Asn Arg Glu His  Val Arg Lys Leu Thr  Lys Lys Gln 
    2195                 2200                 2205             


Met Pro  Ala Val Tyr Lys Ala  Val Asn Ala Leu Gln  Ala Thr Lys 
    2210                 2215                 2220             


Trp Gln  Val Asn Lys Glu Val  Leu Gln Val Val Glu  Asp Val Ile 
    2225                 2230                 2235             


Arg Leu  Asp Leu Gly Tyr Gly  Val Pro Ser Phe Lys  Pro Leu Ile 
    2240                 2245                 2250             


Asp Arg  Glu Asn Lys Pro Ala  Asn Pro Val Pro Leu  Glu Phe Gln 
    2255                 2260                 2265             


His Leu  Arg Gly Arg Glu Leu  Lys Glu Met Leu Thr  Pro Glu Gln 
    2270                 2275                 2280             


Trp Gln  Ala Phe Ile Asn Trp  Lys Gly Glu Cys Thr  Lys Leu Tyr 
    2285                 2290                 2295             


Thr Ala  Glu Thr Lys Arg Gly  Ser Lys Ser Ala Ala  Thr Val Arg 
    2300                 2305                 2310             


Met Val  Gly Gln Ala Arg Lys  Tyr Ser Gln Phe Asp  Ala Ile Tyr 
    2315                 2320                 2325             


Phe Val  Tyr Ala Leu Asp Ser  Arg Ser Arg Val Tyr  Ala Gln Ser 
    2330                 2335                 2340             


Ser Thr  Leu Ser Pro Gln Ser  Asn Asp Leu Gly Lys  Ala Leu Leu 
    2345                 2350                 2355             


Arg Phe  Thr Glu Gly Gln Arg  Leu Asp Ser Ala Glu  Ala Leu Lys 
    2360                 2365                 2370             


Trp Phe  Leu Val Asn Gly Ala  Asn Asn Trp Gly Trp  Asp Lys Lys 
    2375                 2380                 2385             


Thr Phe  Asp Val Arg Thr Ala  Asn Val Leu Asp Ser  Glu Phe Gln 
    2390                 2395                 2400             


Asp Met  Cys Arg Asp Ile Ala  Ala Asp Pro Leu Thr  Phe Thr Gln 
    2405                 2410                 2415             


Trp Val  Asn Ala Asp Ser Pro  Tyr Gly Phe Leu Ala  Trp Cys Phe 
    2420                 2425                 2430             


Glu Tyr  Ala Arg Tyr Leu Asp  Ala Leu Asp Glu Gly  Thr Gln Asp 
    2435                 2440                 2445             


Gln Phe  Met Thr His Leu Pro  Val His Gln Asp Gly  Ser Cys Ser 
    2450                 2455                 2460             


Gly Ile  Gln His Tyr Ser Ala  Met Leu Ser Asp Ala  Val Gly Ala 
    2465                 2470                 2475             


Lys Ala  Val Asn Leu Lys Pro  Ser Asp Ser Pro Gln  Asp Ile Tyr 
    2480                 2485                 2490             


Gly Ala  Val Ala Gln Val Val  Ile Gln Lys Asn Tyr  Ala Tyr Met 
    2495                 2500                 2505             


Asn Ala  Glu Asp Ala Glu Thr  Phe Thr Ser Gly Ser  Val Thr Leu 
    2510                 2515                 2520             


Thr Gly  Ala Glu Leu Arg Ser  Met Ala Ser Ala Trp  Asp Met Ile 
    2525                 2530                 2535             


Gly Ile  Thr Arg Gly Leu Thr  Lys Lys Pro Val Met  Thr Leu Pro 
    2540                 2545                 2550             


Tyr Gly  Ser Thr Arg Leu Thr  Cys Arg Glu Ser Val  Ile Asp Tyr 
    2555                 2560                 2565             


Ile Val  Asp Leu Glu Glu Lys  Glu Ala Gln Arg Ala  Ile Ala Glu 
    2570                 2575                 2580             


Gly Arg  Thr Ala Asn Pro Val  His Pro Phe Asp Asn  Asp Arg Lys 
    2585                 2590                 2595             


Asp Ser  Leu Thr Pro Ser Ala  Ala Tyr Asn Tyr Met  Thr Ala Leu 
    2600                 2605                 2610             


Ile Trp  Pro Ser Ile Ser Glu  Val Val Lys Ala Pro  Ile Val Ala 
    2615                 2620                 2625             


Met Lys  Met Ile Arg Gln Leu  Ala Arg Phe Ala Ala  Lys Arg Asn 
    2630                 2635                 2640             


Glu Gly  Leu Glu Tyr Pro Leu  Pro Thr Gly Phe Ile  Leu Gln Gln 
    2645                 2650                 2655             


Lys Ile  Met Ala Thr Asp Met  Leu Arg Val Ser Thr  Cys Leu Met 
    2660                 2665                 2670             


Gly Glu  Ile Lys Met Ser Leu  Gln Ile Glu Thr Asp  Val Val Asp 
    2675                 2680                 2685             


Glu Thr  Ala Met Met Gly Ala  Ala Ala Pro Asn Phe  Val His Gly 
    2690                 2695                 2700             


His Asp  Ala Ser His Leu Ile  Leu Thr Val Cys Asp  Leu Val Asp 
    2705                 2710                 2715             


Lys Gly  Ile Thr Ser Val Ala  Val Ile His Asp Ser  Phe Gly Thr 
    2720                 2725                 2730             


His Ala  Gly Arg Thr Ala Asp  Leu Arg Asp Ser Leu  Arg Glu Glu 
    2735                 2740                 2745             


Met Val  Lys Met Tyr Gln Asn  His Asn Ala Leu Gln  Asn Leu Leu 
    2750                 2755                 2760             


Asp Val  His Glu Glu Arg Trp  Leu Val Asp Thr Gly  Ile Gln Val 
    2765                 2770                 2775             


Pro Glu  Gln Gly Glu Phe Asp  Leu Asn Glu Ile Leu  Val Ser Asp 
    2780                 2785                 2790             


Tyr Cys  Phe Ala 
    2795         


<210>  29
<211>  66
<212>  DNA
<213>  Enterobacteria phage lambda

<400>  29
atggatgctc agaccagacg cagagaacgg cgggcagaga agcaggcaca gtggaaggcc       60

gctaat                                                                  66


<210>  30
<211>  22
<212>  PRT
<213>  Enterobacteria phage lambda

<400>  30

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn 
            20          


<210>  31
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  boxBL

<400>  31
gccctgaaaa agggc                                                        15


<210>  32
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BoxBR

<400>  32
acatgaggat cacccatgt                                                    19


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker G4S

<400>  33

Gly Gly Gly Gly Ser 
1               5   


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker (G4S)2

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  35
<211>  8889
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pC3P3f plasmid

<400>  35
atggctggcg atctgagcgc cggttttttc atggaagaac tcaatactta tagacaaaaa       60

cagggagtgg tccttaagta ccaggagctt cctaattcag gtccccccca cgatcgaaga      120

ttcacgtttc aggtgatcat cgatggcaga gaattccccg aaggcgaggg acgctcaaag      180

aaagaggcta agaatgctgc ggccaagctt gccgtcgaaa tcctgaataa ggaaaaaaag      240

gcagttagcc cgttgctgtt gaccaccacg aattcgtcag aaggactatc tatgggcaac      300

tacatagggt tgattaacag gatcgcccag aaaaaacggc ttaccgttaa ttatgagcaa      360

tgcgctagtg gtgtgcacgg cccggaaggg ttccattaca aatgcaaaat gggtcagaag      420

gagtacagca ttgggaccgg cagtacaaaa caggaagcaa agcagctggc cgccaagcta      480

gcatatcttc agattctgtc cggaggagga ggctctggtg gtggcgggag cagccggcgg      540

aacaagcgga gccggcggcg gcggaagaag cccctgaaca ccatccagcc cggccccagc      600

aagcccagcg cccaggacga gcccatcaag agcgtgagcc accacagcag caagatcggc      660

accaacccca tgctggcctt catcctgggc ggcaacgagg acctgagcga cgacagcgac      720

tgggacgagg acttcagcct ggagaacacc ctgatgcccc tgaacgaggt gagcctgaag      780

ggcaagcacg acagcaagca cttcaacaag ggcttcgaca acaacaccgc cctgcacgag      840

gtgaacacca agtgggaggc cttctacagc agcgtgaaga tccggcagcg ggacgtgaag      900

gtgtacttcg ccaccgacga catcctgatc aaggtgcggg aggccgacga catcgaccgg      960

aagggcccct gggagcaggc cgccgtggac cggctgcggt tccagcggcg gatcgccgac     1020

accgagaaga tcctgagcgc cgtgctgctg cggaagaagc tgaaccccat ggagcacgag     1080

ggatcaggcc cgcgacccct ccttgccatc cacccaaccg aggcacggca caagcagaaa     1140

atagtggcac ccgttaagca gactctcaac tttgatctcc tgaagcttgc cggcgacgta     1200

gagtccaacc ccggccccga tgctcagacc agacgcagag aacggcgggc agagaagcag     1260

gcacagtgga aggccgctaa tccgtttcca gttacaacgc agggatcaca acaaacgcag     1320

ccaccacaga ggcactatgg cattacctct cctatcagct tagcggcccc caaggagact     1380

gactgcctac tcacacagaa gctcatcgag acgctgaagc cctttggggt ttttgaagaa     1440

gaagaggaac tgcagcgcag gattttaatt ttgggaaaat taaataacct ggtgaaagaa     1500

tggattcgag aaatcagtga aagcaagaat ctcccacaat ctgtaattga aaatgttgga     1560

gggaagattt ttacatttgg atcttacaga ctaggagtcc acacgaaagg tgctgatatt     1620

gatgcgttgt gtgttgcacc aagacatgtt gatcgaagtg actttttcac ctcattctat     1680

gataaattga aattacaaga agaagtgaaa gatttaagag ctgttgaaga ggcatttgta     1740

ccagttatca aactctgttt tgatggaata gagattgata ttttgtttgc aagattagca     1800

ctgcagacta ttccagaaga tttggaccta cgagatgaca gtctgcttaa aaacctagat     1860

ataagatgca taagaagcct taatggttgc agggtaaccg atgaaatttt acatctagta     1920

ccaaacattg acaacttcag gttaactctg agagccatca aactgtgggc caaacggcac     1980

aacatctatt ccaatatatt aggtttcctc ggtggtgttt cctgggctat gctagtagca     2040

agaacttgcc agctttatcc aaatgcaata gcatcaactc ttgtacataa atttttcttg     2100

gtattttcta aatgggaatg gccaaatcca gtgctattga aacagcctga agaatgcaat     2160

cttaatttgc ctgtgtggga cccaagggta aaccccagtg ataggtacca tcttatgcct     2220

ataattacac cagcataccc acagcagaac tccacgtaca atgtgtccgt ttcaacacgg     2280

atggtcatgg ttgaggagtt taaacaaggt cttgctatca cagatgaaat tttgctgagt     2340

aaggcagagt ggtccaaact ttttgaagct ccaaacttct ttcagaagta caagcattat     2400

attgtacttc tagcaagtgc gcccacggaa aagcagcgtc tggaatgggt gggcttggtg     2460

gaatcaaaaa tccgcatcct ggttggaagc ttggagaaga atgagtttat tacactggct     2520

catgtgaatc cccagtcatt tccagccccc aaagaaagtc ctgacaggga agaatttcgc     2580

acaatgtggg tgattgggtt agtgtttaaa aaaactgaaa actctgaaaa tctcagtgtc     2640

gacctcacct atgatatcca gtctttcaca gacacagttt ataggcaagc aataaacagc     2700

aaaatgtttg agttggatat gaagattgca gcaatgcatg tgaagagaaa gcaactccat     2760

cagctgctgc ctagtcacgt gcttcagaag aggaagaagc attcaacaga aggagtcaag     2820

ttaacagctc tgaatgacag cagccttgac ttgtctatgg acagtgataa cagcatgtct     2880

gtgccttcac ccaccagtgc tatgaagacc agtccattga atagttctgg cagctcccag     2940

ggcagaaaca gtcctgctcc agctgtgacc gcagcatctg tgaccagcat ccaggcttct     3000

gaggtttctg taccgcaagc aaattccagt gaaagcccag ggggtccatc gagcgaaagc     3060

attcctcaaa ctgccacaca gccagccatt gccccaccac caaagcctac agtctccaga     3120

gttgtctcct caacacgact ggtaaaccca tcgcctagac cttcaggaaa cacagcaaca     3180

aaagtcccta atcctatagt aggagtcaag agaacgtccg cccccaataa agaagaagcc     3240

cctagaagga ccaaaacaga agaggatgaa acaagtgaag atgctaactg tcttgctttg     3300

agtggacatg ataaaacaga gacaaaggaa caagttgatc tggagacaag tgcggttcaa     3360

tcagaaactg ttccggcatc ggcttctctg ttggcctctc agaaaacatc cagtacagac     3420

ctttctgata tccctgctct ccctgcaaat cctattcctg ttatcaagaa ctcaataaaa     3480

ctgagactga atcggggatc aggcccgcga cccctccttg ccatccaccc aaccgaggca     3540

cggcacaagc agaaaatagt ggcacccgtt aagcagactc tcaactttga tctcctgaag     3600

cttgccggcg acgtagagtc caaccccggc cccgccagcc tggacaacct ggtggccaga     3660

taccagcggt gcttcaacga ccagagcctg aagaacagca ccatcgagct ggaaatccgg     3720

ttccagcaga tcaacttcct gctgttcaag accgtgtacg aggccctggt cgcccaggaa     3780

atccccagca ccatcagcca cagcatccgg tgcatcaaga aggtgcacca cgagaaccac     3840

tgccgggaga agatcctgcc cagcgagaac ctgtacttca agaaacagcc cctgatgttc     3900

ttcaagttca gcgagcccgc cagcctgggc tgtaaagtgt ccctggccat cgagcagccc     3960

atccggaagt tcatcctgga cagcagcgtg ctggtccggc tgaagaaccg gaccaccttc     4020

cgggtgtccg agctgtggaa gatcgagctg accatcgtga agcagctgat gggcagcgag     4080

gtgtcagcca agctggccgc cttcaagacc ctgctgttcg acacccccga gcagcagacc     4140

accaagaaca tgatgaccct gatcaacccc gacgacgagt acctgtacga gatcgagatc     4200

gagtacaccg gcaagcctga gagcctgaca gccgccgacg tgatcaagat caagaacacc     4260

gtgctgacac tgatcagccc caaccacctg atgctgaccg cctaccacca ggccatcgag     4320

tttatcgcca gccacatcct gagcagcgag atcctgctgg cccggatcaa gagcggcaag     4380

tggggcctga agagactgct gccccaggtc aagtccatga ccaaggccga ctacatgaag     4440

ttctaccccc ccgtgggcta ctacgtgacc gacaaggccg acggcatccg gggcattgcc     4500

gtgatccagg acacccagat ctacgtggtg gccgaccagc tgtacagcct gggcaccacc     4560

ggcatcgagc ccctgaagcc caccatcctg gacggcgagt tcatgcccga gaagaaagag     4620

ttctacggct ttgacgtgat catgtacgag ggcaacctgc tgacccagca gggcttcgag     4680

acacggatcg agagcctgag caagggcatc aaggtgctgc aggccttcaa catcaaggcc     4740

gagatgaagc ccttcatcag cctgacctcc gccgacccca acgtgctgct gaagaatttc     4800

gagagcatct tcaagaagaa aacccggccc tacagcatcg acggcatcat cctggtggag     4860

cccggcaaca gctacctgaa caccaacacc ttcaagtgga agcccacctg ggacaacacc     4920

ctggactttc tggtccggaa gtgccccgag tccctgaacg tgcccgagta cgcccccaag     4980

aagggcttca gcctgcatct gctgttcgtg ggcatcagcg gcgagctgtt taagaagctg     5040

gccctgaact ggtgccccgg ctacaccaag ctgttccccg tgacccagcg gaaccagaac     5100

tacttccccg tgcagttcca gcccagcgac ttccccctgg ccttcctgta ctaccacccc     5160

gacaccagca gcttcagcaa catcgatggc aaggtgctgg aaatgcggtg cctgaagcgg     5220

gagatcaact acgtgcgctg ggagatcgtg aagatccggg aggaccggca gcaggatctg     5280

aaaaccggcg gctacttcgg caacgacttc aagaccgccg agctgacctg gctgaactac     5340

atggacccct tcagcttcga ggaactggcc aagggaccca gcggcatgta cttcgctggc     5400

gccaagaccg gcatctacag agcccagacc gccctgatca gcttcatcaa gcaggaaatc     5460

atccagaaga tcagccacca gagctgggtg atcgacctgg gcatcggcaa gggccaggac     5520

ctgggcagat acctggacgc cggcgtgaga cacctggtcg gcatcgataa ggaccagaca     5580

gccctggccg agctggtgta ccggaagttc tcccacgcca ccaccagaca gcacaagcac     5640

gccaccaaca tctacgtgct gcaccaggat ctggccgagc ctgccaaaga aatcagcgag     5700

aaagtgcacc agatctatgg cttccccaaa gagggcgcca gcagcatcgt gtccaacctg     5760

ttcatccact acctgatgaa gaacacccag caggtcgaga acctggctgt gctgtgccac     5820

aagctgctgc agcctggcgg catggtctgg ttcaccacca tgctgggcga acaggtgctg     5880

gaactgctgc acgagaaccg gatcgaactg aacgaagtgt gggaggcccg ggagaacgag     5940

gtggtcaagt tcgccatcaa gcggctgttc aaagaggaca tcctgcagga aaccggccag     6000

gaaatcggcg tcctgctgcc cttcagcaac ggcgacttct acaatgagta cctggtcaac     6060

accgcctttc tgatcaagat tttcaagcac catggcttta gcctcgtgca gaagcagagc     6120

ttcaaggact ggatccccga gttccagaac ttcagcaaga gcctgtacaa gatcctgacc     6180

gaggccgaca agacctggac cagcctgttc ggcttcatct gcctgcggaa gaacggaggc     6240

gggggaagtg gagggggcgg cagtcaggac ctgcacgcca tccagctgca gctcgaagag     6300

gaaatgttca acggcggcat cagaagattc gaggccgacc agcagagaca gatcgcctct     6360

ggcaacgaga gcgacaccgc ctggaataga aggctgctgt ctgagctgat cgcccctatg     6420

gccgaaggca tccaggccta caaagaggaa tacgagggca agagaggcag agcccctaga     6480

gccctggcct tcatcaactg tgtgggcaat gaggtggccg cctacatcac catgaagatc     6540

gtgatggaca tgctgaacac cgacgtgacc ctgcaggcca ttgccatgaa cgtggccgac     6600

agaatcgagg accaggtccg attcagcaag ctggaaggac acgccgccaa gtacttcgag     6660

aaagtgaaga agtccctgaa ggccagcaag accaagagct acagacacgc ccacaacgtg     6720

gccgtggtgg ccgaaaaatc tgtggccgat agggacgccg acttctctag atgggaggcc     6780

tggcctaagg acaccctgct gcagatcggc atgaccctgc tggaaatcct ggaaaacagc     6840

gtgttcttca acggccagcc cgtgttcctg agaaccctga ggacaaatgg cggcaagcac     6900

ggcgtgtact acctgcagac atctgagcac gtgggcgagt ggatcaccgc cttcaaagaa     6960

catgtggccc agctgagccc tgcctatgcc ccttgtgtga tccctcctag accctgggtg     7020

tcccctttca atggcggctt tcacaccgag aaggtggcca gcagaatcag actggtcaag     7080

ggcaaccggg aacacgtgcg gaagctgacc aagaaacaga tgcccgccgt gtacaaggcc     7140

gtgaatgctc tgcaggccac caagtggcag gtcaacaaag aggtgctgca ggtcgtcgag     7200

gacgtgatca gactggatct gggctacggc gtgccaagct ttaagcccct gatcgacaga     7260

gagaacaagc ccgccaaccc tgtgcccctg gaatttcagc acctgagagg ccgcgagctg     7320

aaagagatgc tgacacctga acagtggcag gcctttatca attggaaggg cgagtgcacc     7380

aagctgtaca ccgccgagac aaagaggggc tctaagtctg ccgccacagt gcgaatggtc     7440

ggacaggcca gaaagtacag ccagttcgac gccatctact tcgtgtacgc cctggacagc     7500

cggtctagag tgtatgccca gagcagcaca ctgagccccc agtctaacga tctgggaaag     7560

gccctgctga gattcaccga gggccagaga ctggattctg ccgaagccct gaagtggttc     7620

ctggtcaacg gcgccaacaa ctggggctgg gacaagaaaa ccttcgatgt gcggaccgcc     7680

aacgtgctgg atagcgagtt ccaggacatg tgcagagata tcgccgccga ccctctgacc     7740

tttacccagt gggtcaacgc cgatagcccc tatggattcc tggcctggtg cttcgagtac     7800

gccagatacc tggacgccct ggatgaggga acccaggatc agttcatgac ccatctgccc     7860

gtgcaccagg atggctcttg ttctggcatc cagcactaca gcgccatgct gagcgatgcc     7920

gtgggagcca aagccgtgaa cctgaagcct agcgacagcc cccaggatat ctatggcgct     7980

gtggcccagg tggtcatcca gaaaaactac gcctacatga acgccgagga cgccgagaca     8040

ttcacaagcg gaagcgtgac actgacaggc gccgagctga gatctatggc ctctgcctgg     8100

gacatgatcg gcatcacacg gggcctgacc aaaaagcctg tgatgacact gccctacggc     8160

agcaccagac tgacctgtag agaaagcgtg atcgactaca tcgtggacct ggaagagaaa     8220

gaggcccaga gagccattgc cgagggcaga acagccaatc ctgtgcaccc cttcgacaac     8280

gaccggaagg atagcctgac acctagcgcc gcctacaact acatgaccgc cctgatctgg     8340

cccagcatct ctgaagtggt caaggcccct atcgtggcca tgaagatgat cagacagctg     8400

gccagattcg ccgccaagag aaatgagggc ctggaatacc ctctgcccac cggctttatc     8460

ctgcagcaga aaatcatggc caccgacatg ctgcgggtgt ccacatgtct gatgggcgag     8520

atcaagatga gcctgcagat cgagacagac gtggtggacg agacagccat gatgggagcc     8580

gccgctccta attttgtgca cggacacgat gccagccacc tgatcctgac cgtgtgcgat     8640

ctggtggaca agggcatcac tagcgtggcc gtgatccacg atagctttgg aacacacgcc     8700

ggcagaaccg ccgacctgag agattctctg cgggaagaga tggtcaagat gtaccagaac     8760

cacaacgccc tgcagaacct gctggacgtg cacgaagaaa gatggctggt ggacaccggc     8820

atccaggtgc cagaacaggg agagttcgac ctgaacgaga tcctggtgtc cgactactgc     8880

ttcgcctga                                                             8889


<210>  36
<211>  2962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pC3P3-G3f plasmid

<400>  36

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Ser Arg Arg Asn Lys Arg Ser Arg Arg Arg Arg Lys Lys Pro Leu 
            180                 185                 190         


Asn Thr Ile Gln Pro Gly Pro Ser Lys Pro Ser Ala Gln Asp Glu Pro 
        195                 200                 205             


Ile Lys Ser Val Ser His His Ser Ser Lys Ile Gly Thr Asn Pro Met 
    210                 215                 220                 


Leu Ala Phe Ile Leu Gly Gly Asn Glu Asp Leu Ser Asp Asp Ser Asp 
225                 230                 235                 240 


Trp Asp Glu Asp Phe Ser Leu Glu Asn Thr Leu Met Pro Leu Asn Glu 
                245                 250                 255     


Val Ser Leu Lys Gly Lys His Asp Ser Lys His Phe Asn Lys Gly Phe 
            260                 265                 270         


Asp Asn Asn Thr Ala Leu His Glu Val Asn Thr Lys Trp Glu Ala Phe 
        275                 280                 285             


Tyr Ser Ser Val Lys Ile Arg Gln Arg Asp Val Lys Val Tyr Phe Ala 
    290                 295                 300                 


Thr Asp Asp Ile Leu Ile Lys Val Arg Glu Ala Asp Asp Ile Asp Arg 
305                 310                 315                 320 


Lys Gly Pro Trp Glu Gln Ala Ala Val Asp Arg Leu Arg Phe Gln Arg 
                325                 330                 335     


Arg Ile Ala Asp Thr Glu Lys Ile Leu Ser Ala Val Leu Leu Arg Lys 
            340                 345                 350         


Lys Leu Asn Pro Met Glu His Glu Gly Ser Gly Pro Arg Pro Leu Leu 
        355                 360                 365             


Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro 
    370                 375                 380                 


Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
385                 390                 395                 400 


Glu Ser Asn Pro Gly Pro Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg 
                405                 410                 415     


Ala Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Pro Phe Pro Val Thr 
            420                 425                 430         


Thr Gln Gly Ser Gln Gln Thr Gln Pro Pro Gln Arg His Tyr Gly Ile 
        435                 440                 445             


Thr Ser Pro Ile Ser Leu Ala Ala Pro Lys Glu Thr Asp Cys Leu Leu 
    450                 455                 460                 


Thr Gln Lys Leu Ile Glu Thr Leu Lys Pro Phe Gly Val Phe Glu Glu 
465                 470                 475                 480 


Glu Glu Glu Leu Gln Arg Arg Ile Leu Ile Leu Gly Lys Leu Asn Asn 
                485                 490                 495     


Leu Val Lys Glu Trp Ile Arg Glu Ile Ser Glu Ser Lys Asn Leu Pro 
            500                 505                 510         


Gln Ser Val Ile Glu Asn Val Gly Gly Lys Ile Phe Thr Phe Gly Ser 
        515                 520                 525             


Tyr Arg Leu Gly Val His Thr Lys Gly Ala Asp Ile Asp Ala Leu Cys 
    530                 535                 540                 


Val Ala Pro Arg His Val Asp Arg Ser Asp Phe Phe Thr Ser Phe Tyr 
545                 550                 555                 560 


Asp Lys Leu Lys Leu Gln Glu Glu Val Lys Asp Leu Arg Ala Val Glu 
                565                 570                 575     


Glu Ala Phe Val Pro Val Ile Lys Leu Cys Phe Asp Gly Ile Glu Ile 
            580                 585                 590         


Asp Ile Leu Phe Ala Arg Leu Ala Leu Gln Thr Ile Pro Glu Asp Leu 
        595                 600                 605             


Asp Leu Arg Asp Asp Ser Leu Leu Lys Asn Leu Asp Ile Arg Cys Ile 
    610                 615                 620                 


Arg Ser Leu Asn Gly Cys Arg Val Thr Asp Glu Ile Leu His Leu Val 
625                 630                 635                 640 


Pro Asn Ile Asp Asn Phe Arg Leu Thr Leu Arg Ala Ile Lys Leu Trp 
                645                 650                 655     


Ala Lys Arg His Asn Ile Tyr Ser Asn Ile Leu Gly Phe Leu Gly Gly 
            660                 665                 670         


Val Ser Trp Ala Met Leu Val Ala Arg Thr Cys Gln Leu Tyr Pro Asn 
        675                 680                 685             


Ala Ile Ala Ser Thr Leu Val His Lys Phe Phe Leu Val Phe Ser Lys 
    690                 695                 700                 


Trp Glu Trp Pro Asn Pro Val Leu Leu Lys Gln Pro Glu Glu Cys Asn 
705                 710                 715                 720 


Leu Asn Leu Pro Val Trp Asp Pro Arg Val Asn Pro Ser Asp Arg Tyr 
                725                 730                 735     


His Leu Met Pro Ile Ile Thr Pro Ala Tyr Pro Gln Gln Asn Ser Thr 
            740                 745                 750         


Tyr Asn Val Ser Val Ser Thr Arg Met Val Met Val Glu Glu Phe Lys 
        755                 760                 765             


Gln Gly Leu Ala Ile Thr Asp Glu Ile Leu Leu Ser Lys Ala Glu Trp 
    770                 775                 780                 


Ser Lys Leu Phe Glu Ala Pro Asn Phe Phe Gln Lys Tyr Lys His Tyr 
785                 790                 795                 800 


Ile Val Leu Leu Ala Ser Ala Pro Thr Glu Lys Gln Arg Leu Glu Trp 
                805                 810                 815     


Val Gly Leu Val Glu Ser Lys Ile Arg Ile Leu Val Gly Ser Leu Glu 
            820                 825                 830         


Lys Asn Glu Phe Ile Thr Leu Ala His Val Asn Pro Gln Ser Phe Pro 
        835                 840                 845             


Ala Pro Lys Glu Ser Pro Asp Arg Glu Glu Phe Arg Thr Met Trp Val 
    850                 855                 860                 


Ile Gly Leu Val Phe Lys Lys Thr Glu Asn Ser Glu Asn Leu Ser Val 
865                 870                 875                 880 


Asp Leu Thr Tyr Asp Ile Gln Ser Phe Thr Asp Thr Val Tyr Arg Gln 
                885                 890                 895     


Ala Ile Asn Ser Lys Met Phe Glu Leu Asp Met Lys Ile Ala Ala Met 
            900                 905                 910         


His Val Lys Arg Lys Gln Leu His Gln Leu Leu Pro Ser His Val Leu 
        915                 920                 925             


Gln Lys Arg Lys Lys His Ser Thr Glu Gly Val Lys Leu Thr Ala Leu 
    930                 935                 940                 


Asn Asp Ser Ser Leu Asp Leu Ser Met Asp Ser Asp Asn Ser Met Ser 
945                 950                 955                 960 


Val Pro Ser Pro Thr Ser Ala Met Lys Thr Ser Pro Leu Asn Ser Ser 
                965                 970                 975     


Gly Ser Ser Gln Gly Arg Asn Ser Pro Ala Pro Ala Val Thr Ala Ala 
            980                 985                 990         


Ser Val Thr Ser Ile Gln Ala Ser  Glu Val Ser Val Pro  Gln Ala Asn 
        995                 1000                 1005             


Ser Ser  Glu Ser Pro Gly Gly  Pro Ser Ser Glu Ser  Ile Pro Gln 
    1010                 1015                 1020             


Thr Ala  Thr Gln Pro Ala Ile  Ala Pro Pro Pro Lys  Pro Thr Val 
    1025                 1030                 1035             


Ser Arg  Val Val Ser Ser Thr  Arg Leu Val Asn Pro  Ser Pro Arg 
    1040                 1045                 1050             


Pro Ser  Gly Asn Thr Ala Thr  Lys Val Pro Asn Pro  Ile Val Gly 
    1055                 1060                 1065             


Val Lys  Arg Thr Ser Ala Pro  Asn Lys Glu Glu Ala  Pro Arg Arg 
    1070                 1075                 1080             


Thr Lys  Thr Glu Glu Asp Glu  Thr Ser Glu Asp Ala  Asn Cys Leu 
    1085                 1090                 1095             


Ala Leu  Ser Gly His Asp Lys  Thr Glu Thr Lys Glu  Gln Val Asp 
    1100                 1105                 1110             


Leu Glu  Thr Ser Ala Val Gln  Ser Glu Thr Val Pro  Ala Ser Ala 
    1115                 1120                 1125             


Ser Leu  Leu Ala Ser Gln Lys  Thr Ser Ser Thr Asp  Leu Ser Asp 
    1130                 1135                 1140             


Ile Pro  Ala Leu Pro Ala Asn  Pro Ile Pro Val Ile  Lys Asn Ser 
    1145                 1150                 1155             


Ile Lys  Leu Arg Leu Asn Arg  Gly Ser Gly Pro Arg  Pro Leu Leu 
    1160                 1165                 1170             


Ala Ile  His Pro Thr Glu Ala  Arg His Lys Gln Lys  Ile Val Ala 
    1175                 1180                 1185             


Pro Val  Lys Gln Thr Leu Asn  Phe Asp Leu Leu Lys  Leu Ala Gly 
    1190                 1195                 1200             


Asp Val  Glu Ser Asn Pro Gly  Pro Ala Ser Leu Asp  Asn Leu Val 
    1205                 1210                 1215             


Ala Arg  Tyr Gln Arg Cys Phe  Asn Asp Gln Ser Leu  Lys Asn Ser 
    1220                 1225                 1230             


Thr Ile  Glu Leu Glu Ile Arg  Phe Gln Gln Ile Asn  Phe Leu Leu 
    1235                 1240                 1245             


Phe Lys  Thr Val Tyr Glu Ala  Leu Val Ala Gln Glu  Ile Pro Ser 
    1250                 1255                 1260             


Thr Ile  Ser His Ser Ile Arg  Cys Ile Lys Lys Val  His His Glu 
    1265                 1270                 1275             


Asn His  Cys Arg Glu Lys Ile  Leu Pro Ser Glu Asn  Leu Tyr Phe 
    1280                 1285                 1290             


Lys Lys  Gln Pro Leu Met Phe  Phe Lys Phe Ser Glu  Pro Ala Ser 
    1295                 1300                 1305             


Leu Gly  Cys Lys Val Ser Leu  Ala Ile Glu Gln Pro  Ile Arg Lys 
    1310                 1315                 1320             


Phe Ile  Leu Asp Ser Ser Val  Leu Val Arg Leu Lys  Asn Arg Thr 
    1325                 1330                 1335             


Thr Phe  Arg Val Ser Glu Leu  Trp Lys Ile Glu Leu  Thr Ile Val 
    1340                 1345                 1350             


Lys Gln  Leu Met Gly Ser Glu  Val Ser Ala Lys Leu  Ala Ala Phe 
    1355                 1360                 1365             


Lys Thr  Leu Leu Phe Asp Thr  Pro Glu Gln Gln Thr  Thr Lys Asn 
    1370                 1375                 1380             


Met Met  Thr Leu Ile Asn Pro  Asp Asp Glu Tyr Leu  Tyr Glu Ile 
    1385                 1390                 1395             


Glu Ile  Glu Tyr Thr Gly Lys  Pro Glu Ser Leu Thr  Ala Ala Asp 
    1400                 1405                 1410             


Val Ile  Lys Ile Lys Asn Thr  Val Leu Thr Leu Ile  Ser Pro Asn 
    1415                 1420                 1425             


His Leu  Met Leu Thr Ala Tyr  His Gln Ala Ile Glu  Phe Ile Ala 
    1430                 1435                 1440             


Ser His  Ile Leu Ser Ser Glu  Ile Leu Leu Ala Arg  Ile Lys Ser 
    1445                 1450                 1455             


Gly Lys  Trp Gly Leu Lys Arg  Leu Leu Pro Gln Val  Lys Ser Met 
    1460                 1465                 1470             


Thr Lys  Ala Asp Tyr Met Lys  Phe Tyr Pro Pro Val  Gly Tyr Tyr 
    1475                 1480                 1485             


Val Thr  Asp Lys Ala Asp Gly  Ile Arg Gly Ile Ala  Val Ile Gln 
    1490                 1495                 1500             


Asp Thr  Gln Ile Tyr Val Val  Ala Asp Gln Leu Tyr  Ser Leu Gly 
    1505                 1510                 1515             


Thr Thr  Gly Ile Glu Pro Leu  Lys Pro Thr Ile Leu  Asp Gly Glu 
    1520                 1525                 1530             


Phe Met  Pro Glu Lys Lys Glu  Phe Tyr Gly Phe Asp  Val Ile Met 
    1535                 1540                 1545             


Tyr Glu  Gly Asn Leu Leu Thr  Gln Gln Gly Phe Glu  Thr Arg Ile 
    1550                 1555                 1560             


Glu Ser  Leu Ser Lys Gly Ile  Lys Val Leu Gln Ala  Phe Asn Ile 
    1565                 1570                 1575             


Lys Ala  Glu Met Lys Pro Phe  Ile Ser Leu Thr Ser  Ala Asp Pro 
    1580                 1585                 1590             


Asn Val  Leu Leu Lys Asn Phe  Glu Ser Ile Phe Lys  Lys Lys Thr 
    1595                 1600                 1605             


Arg Pro  Tyr Ser Ile Asp Gly  Ile Ile Leu Val Glu  Pro Gly Asn 
    1610                 1615                 1620             


Ser Tyr  Leu Asn Thr Asn Thr  Phe Lys Trp Lys Pro  Thr Trp Asp 
    1625                 1630                 1635             


Asn Thr  Leu Asp Phe Leu Val  Arg Lys Cys Pro Glu  Ser Leu Asn 
    1640                 1645                 1650             


Val Pro  Glu Tyr Ala Pro Lys  Lys Gly Phe Ser Leu  His Leu Leu 
    1655                 1660                 1665             


Phe Val  Gly Ile Ser Gly Glu  Leu Phe Lys Lys Leu  Ala Leu Asn 
    1670                 1675                 1680             


Trp Cys  Pro Gly Tyr Thr Lys  Leu Phe Pro Val Thr  Gln Arg Asn 
    1685                 1690                 1695             


Gln Asn  Tyr Phe Pro Val Gln  Phe Gln Pro Ser Asp  Phe Pro Leu 
    1700                 1705                 1710             


Ala Phe  Leu Tyr Tyr His Pro  Asp Thr Ser Ser Phe  Ser Asn Ile 
    1715                 1720                 1725             


Asp Gly  Lys Val Leu Glu Met  Arg Cys Leu Lys Arg  Glu Ile Asn 
    1730                 1735                 1740             


Tyr Val  Arg Trp Glu Ile Val  Lys Ile Arg Glu Asp  Arg Gln Gln 
    1745                 1750                 1755             


Asp Leu  Lys Thr Gly Gly Tyr  Phe Gly Asn Asp Phe  Lys Thr Ala 
    1760                 1765                 1770             


Glu Leu  Thr Trp Leu Asn Tyr  Met Asp Pro Phe Ser  Phe Glu Glu 
    1775                 1780                 1785             


Leu Ala  Lys Gly Pro Ser Gly  Met Tyr Phe Ala Gly  Ala Lys Thr 
    1790                 1795                 1800             


Gly Ile  Tyr Arg Ala Gln Thr  Ala Leu Ile Ser Phe  Ile Lys Gln 
    1805                 1810                 1815             


Glu Ile  Ile Gln Lys Ile Ser  His Gln Ser Trp Val  Ile Asp Leu 
    1820                 1825                 1830             


Gly Ile  Gly Lys Gly Gln Asp  Leu Gly Arg Tyr Leu  Asp Ala Gly 
    1835                 1840                 1845             


Val Arg  His Leu Val Gly Ile  Asp Lys Asp Gln Thr  Ala Leu Ala 
    1850                 1855                 1860             


Glu Leu  Val Tyr Arg Lys Phe  Ser His Ala Thr Thr  Arg Gln His 
    1865                 1870                 1875             


Lys His  Ala Thr Asn Ile Tyr  Val Leu His Gln Asp  Leu Ala Glu 
    1880                 1885                 1890             


Pro Ala  Lys Glu Ile Ser Glu  Lys Val His Gln Ile  Tyr Gly Phe 
    1895                 1900                 1905             


Pro Lys  Glu Gly Ala Ser Ser  Ile Val Ser Asn Leu  Phe Ile His 
    1910                 1915                 1920             


Tyr Leu  Met Lys Asn Thr Gln  Gln Val Glu Asn Leu  Ala Val Leu 
    1925                 1930                 1935             


Cys His  Lys Leu Leu Gln Pro  Gly Gly Met Val Trp  Phe Thr Thr 
    1940                 1945                 1950             


Met Leu  Gly Glu Gln Val Leu  Glu Leu Leu His Glu  Asn Arg Ile 
    1955                 1960                 1965             


Glu Leu  Asn Glu Val Trp Glu  Ala Arg Glu Asn Glu  Val Val Lys 
    1970                 1975                 1980             


Phe Ala  Ile Lys Arg Leu Phe  Lys Glu Asp Ile Leu  Gln Glu Thr 
    1985                 1990                 1995             


Gly Gln  Glu Ile Gly Val Leu  Leu Pro Phe Ser Asn  Gly Asp Phe 
    2000                 2005                 2010             


Tyr Asn  Glu Tyr Leu Val Asn  Thr Ala Phe Leu Ile  Lys Ile Phe 
    2015                 2020                 2025             


Lys His  His Gly Phe Ser Leu  Val Gln Lys Gln Ser  Phe Lys Asp 
    2030                 2035                 2040             


Trp Ile  Pro Glu Phe Gln Asn  Phe Ser Lys Ser Leu  Tyr Lys Ile 
    2045                 2050                 2055             


Leu Thr  Glu Ala Asp Lys Thr  Trp Thr Ser Leu Phe  Gly Phe Ile 
    2060                 2065                 2070             


Cys Leu  Arg Lys Asn Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    2075                 2080                 2085             


Gln Asp  Leu His Ala Ile Gln  Leu Gln Leu Glu Glu  Glu Met Phe 
    2090                 2095                 2100             


Asn Gly  Gly Ile Arg Arg Phe  Glu Ala Asp Gln Gln  Arg Gln Ile 
    2105                 2110                 2115             


Ala Ser  Gly Asn Glu Ser Asp  Thr Ala Trp Asn Arg  Arg Leu Leu 
    2120                 2125                 2130             


Ser Glu  Leu Ile Ala Pro Met  Ala Glu Gly Ile Gln  Ala Tyr Lys 
    2135                 2140                 2145             


Glu Glu  Tyr Glu Gly Lys Arg  Gly Arg Ala Pro Arg  Ala Leu Ala 
    2150                 2155                 2160             


Phe Ile  Asn Cys Val Gly Asn  Glu Val Ala Ala Tyr  Ile Thr Met 
    2165                 2170                 2175             


Lys Ile  Val Met Asp Met Leu  Asn Thr Asp Val Thr  Leu Gln Ala 
    2180                 2185                 2190             


Ile Ala  Met Asn Val Ala Asp  Arg Ile Glu Asp Gln  Val Arg Phe 
    2195                 2200                 2205             


Ser Lys  Leu Glu Gly His Ala  Ala Lys Tyr Phe Glu  Lys Val Lys 
    2210                 2215                 2220             


Lys Ser  Leu Lys Ala Ser Lys  Thr Lys Ser Tyr Arg  His Ala His 
    2225                 2230                 2235             


Asn Val  Ala Val Val Ala Glu  Lys Ser Val Ala Asp  Arg Asp Ala 
    2240                 2245                 2250             


Asp Phe  Ser Arg Trp Glu Ala  Trp Pro Lys Asp Thr  Leu Leu Gln 
    2255                 2260                 2265             


Ile Gly  Met Thr Leu Leu Glu  Ile Leu Glu Asn Ser  Val Phe Phe 
    2270                 2275                 2280             


Asn Gly  Gln Pro Val Phe Leu  Arg Thr Leu Arg Thr  Asn Gly Gly 
    2285                 2290                 2295             


Lys His  Gly Val Tyr Tyr Leu  Gln Thr Ser Glu His  Val Gly Glu 
    2300                 2305                 2310             


Trp Ile  Thr Ala Phe Lys Glu  His Val Ala Gln Leu  Ser Pro Ala 
    2315                 2320                 2325             


Tyr Ala  Pro Cys Val Ile Pro  Pro Arg Pro Trp Val  Ser Pro Phe 
    2330                 2335                 2340             


Asn Gly  Gly Phe His Thr Glu  Lys Val Ala Ser Arg  Ile Arg Leu 
    2345                 2350                 2355             


Val Lys  Gly Asn Arg Glu His  Val Arg Lys Leu Thr  Lys Lys Gln 
    2360                 2365                 2370             


Met Pro  Ala Val Tyr Lys Ala  Val Asn Ala Leu Gln  Ala Thr Lys 
    2375                 2380                 2385             


Trp Gln  Val Asn Lys Glu Val  Leu Gln Val Val Glu  Asp Val Ile 
    2390                 2395                 2400             


Arg Leu  Asp Leu Gly Tyr Gly  Val Pro Ser Phe Lys  Pro Leu Ile 
    2405                 2410                 2415             


Asp Arg  Glu Asn Lys Pro Ala  Asn Pro Val Pro Leu  Glu Phe Gln 
    2420                 2425                 2430             


His Leu  Arg Gly Arg Glu Leu  Lys Glu Met Leu Thr  Pro Glu Gln 
    2435                 2440                 2445             


Trp Gln  Ala Phe Ile Asn Trp  Lys Gly Glu Cys Thr  Lys Leu Tyr 
    2450                 2455                 2460             


Thr Ala  Glu Thr Lys Arg Gly  Ser Lys Ser Ala Ala  Thr Val Arg 
    2465                 2470                 2475             


Met Val  Gly Gln Ala Arg Lys  Tyr Ser Gln Phe Asp  Ala Ile Tyr 
    2480                 2485                 2490             


Phe Val  Tyr Ala Leu Asp Ser  Arg Ser Arg Val Tyr  Ala Gln Ser 
    2495                 2500                 2505             


Ser Thr  Leu Ser Pro Gln Ser  Asn Asp Leu Gly Lys  Ala Leu Leu 
    2510                 2515                 2520             


Arg Phe  Thr Glu Gly Gln Arg  Leu Asp Ser Ala Glu  Ala Leu Lys 
    2525                 2530                 2535             


Trp Phe  Leu Val Asn Gly Ala  Asn Asn Trp Gly Trp  Asp Lys Lys 
    2540                 2545                 2550             


Thr Phe  Asp Val Arg Thr Ala  Asn Val Leu Asp Ser  Glu Phe Gln 
    2555                 2560                 2565             


Asp Met  Cys Arg Asp Ile Ala  Ala Asp Pro Leu Thr  Phe Thr Gln 
    2570                 2575                 2580             


Trp Val  Asn Ala Asp Ser Pro  Tyr Gly Phe Leu Ala  Trp Cys Phe 
    2585                 2590                 2595             


Glu Tyr  Ala Arg Tyr Leu Asp  Ala Leu Asp Glu Gly  Thr Gln Asp 
    2600                 2605                 2610             


Gln Phe  Met Thr His Leu Pro  Val His Gln Asp Gly  Ser Cys Ser 
    2615                 2620                 2625             


Gly Ile  Gln His Tyr Ser Ala  Met Leu Ser Asp Ala  Val Gly Ala 
    2630                 2635                 2640             


Lys Ala  Val Asn Leu Lys Pro  Ser Asp Ser Pro Gln  Asp Ile Tyr 
    2645                 2650                 2655             


Gly Ala  Val Ala Gln Val Val  Ile Gln Lys Asn Tyr  Ala Tyr Met 
    2660                 2665                 2670             


Asn Ala  Glu Asp Ala Glu Thr  Phe Thr Ser Gly Ser  Val Thr Leu 
    2675                 2680                 2685             


Thr Gly  Ala Glu Leu Arg Ser  Met Ala Ser Ala Trp  Asp Met Ile 
    2690                 2695                 2700             


Gly Ile  Thr Arg Gly Leu Thr  Lys Lys Pro Val Met  Thr Leu Pro 
    2705                 2710                 2715             


Tyr Gly  Ser Thr Arg Leu Thr  Cys Arg Glu Ser Val  Ile Asp Tyr 
    2720                 2725                 2730             


Ile Val  Asp Leu Glu Glu Lys  Glu Ala Gln Arg Ala  Ile Ala Glu 
    2735                 2740                 2745             


Gly Arg  Thr Ala Asn Pro Val  His Pro Phe Asp Asn  Asp Arg Lys 
    2750                 2755                 2760             


Asp Ser  Leu Thr Pro Ser Ala  Ala Tyr Asn Tyr Met  Thr Ala Leu 
    2765                 2770                 2775             


Ile Trp  Pro Ser Ile Ser Glu  Val Val Lys Ala Pro  Ile Val Ala 
    2780                 2785                 2790             


Met Lys  Met Ile Arg Gln Leu  Ala Arg Phe Ala Ala  Lys Arg Asn 
    2795                 2800                 2805             


Glu Gly  Leu Glu Tyr Pro Leu  Pro Thr Gly Phe Ile  Leu Gln Gln 
    2810                 2815                 2820             


Lys Ile  Met Ala Thr Asp Met  Leu Arg Val Ser Thr  Cys Leu Met 
    2825                 2830                 2835             


Gly Glu  Ile Lys Met Ser Leu  Gln Ile Glu Thr Asp  Val Val Asp 
    2840                 2845                 2850             


Glu Thr  Ala Met Met Gly Ala  Ala Ala Pro Asn Phe  Val His Gly 
    2855                 2860                 2865             


His Asp  Ala Ser His Leu Ile  Leu Thr Val Cys Asp  Leu Val Asp 
    2870                 2875                 2880             


Lys Gly  Ile Thr Ser Val Ala  Val Ile His Asp Ser  Phe Gly Thr 
    2885                 2890                 2895             


His Ala  Gly Arg Thr Ala Asp  Leu Arg Asp Ser Leu  Arg Glu Glu 
    2900                 2905                 2910             


Met Val  Lys Met Tyr Gln Asn  His Asn Ala Leu Gln  Asn Leu Leu 
    2915                 2920                 2925             


Asp Val  His Glu Glu Arg Trp  Leu Val Asp Thr Gly  Ile Gln Val 
    2930                 2935                 2940             


Pro Glu  Gln Gly Glu Phe Asp  Leu Asn Glu Ile Leu  Val Ser Asp 
    2945                 2950                 2955             


Tyr Cys  Phe Ala 
    2960         


<210>  37
<211>  8997
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pC3P3-G3g plasmid

<400>  37
atggctggcg atctgagcgc cggttttttc atggaagaac tcaatactta tagacaaaaa       60

cagggagtgg tccttaagta ccaggagctt cctaattcag gtccccccca cgatcgaaga      120

ttcacgtttc aggtgatcat cgatggcaga gaattccccg aaggcgaggg acgctcaaag      180

aaagaggcta agaatgctgc ggccaagctt gccgtcgaaa tcctgaataa ggaaaaaaag      240

gcagttagcc cgttgctgtt gaccaccacg aattcgtcag aaggactatc tatgggcaac      300

tacatagggt tgattaacag gatcgcccag aaaaaacggc ttaccgttaa ttatgagcaa      360

tgcgctagtg gtgtgcacgg cccggaaggg ttccattaca aatgcaaaat gggtcagaag      420

gagtacagca ttgggaccgg cagtacaaaa caggaagcaa agcagctggc cgccaagcta      480

gcatatcttc agattctgtc cggatcaggc ccgcgacccc tccttgccat ccacccaacc      540

gaggcacggc acaagcagaa aatagtggca cccgttaagc agactctcaa ctttgatctc      600

ctgaagcttg ccggcgacgt agagtccaac cccggcccca gccggcggaa caagcggagc      660

cggcggcggc ggaagaagcc cctgaacacc atccagcccg gccccagcaa gcccagcgcc      720

caggacgagc ccatcaagag cgtgagccac cacagcagca agatcggcac caaccccatg      780

ctggccttca tcctgggcgg caacgaggac ctgagcgacg acagcgactg ggacgaggac      840

ttcagcctgg agaacaccct gatgcccctg aacgaggtga gcctgaaggg caagcacgac      900

agcaagcact tcaacaaggg cttcgacaac aacaccgccc tgcacgaggt gaacaccaag      960

tgggaggcct tctacagcag cgtgaagatc cggcagcggg acgtgaaggt gtacttcgcc     1020

accgacgaca tcctgatcaa ggtgcgggag gccgacgaca tcgaccggaa gggcccctgg     1080

gagcaggccg ccgtggaccg gctgcggttc cagcggcgga tcgccgacac cgagaagatc     1140

ctgagcgccg tgctgctgcg gaagaagctg aaccccatgg agcacgaggg atcaggcccg     1200

cgacccctcc ttgccatcca cccaaccgag gcacggcaca agcagaaaat agtggcaccc     1260

gttaagcaga ctctcaactt tgatctcctg aagcttgccg gcgacgtaga gtccaacccc     1320

ggccccgatg ctcagaccag acgcagagaa cggcgggcag agaagcaggc acagtggaag     1380

gccgctaatc cgtttccagt tacaacgcag ggatcacaac aaacgcagcc accacagagg     1440

cactatggca ttacctctcc tatcagctta gcggccccca aggagactga ctgcctactc     1500

acacagaagc tcatcgagac gctgaagccc tttggggttt ttgaagaaga agaggaactg     1560

cagcgcagga ttttaatttt gggaaaatta aataacctgg tgaaagaatg gattcgagaa     1620

atcagtgaaa gcaagaatct cccacaatct gtaattgaaa atgttggagg gaagattttt     1680

acatttggat cttacagact aggagtccac acgaaaggtg ctgatattga tgcgttgtgt     1740

gttgcaccaa gacatgttga tcgaagtgac tttttcacct cattctatga taaattgaaa     1800

ttacaagaag aagtgaaaga tttaagagct gttgaagagg catttgtacc agttatcaaa     1860

ctctgttttg atggaataga gattgatatt ttgtttgcaa gattagcact gcagactatt     1920

ccagaagatt tggacctacg agatgacagt ctgcttaaaa acctagatat aagatgcata     1980

agaagcctta atggttgcag ggtaaccgat gaaattttac atctagtacc aaacattgac     2040

aacttcaggt taactctgag agccatcaaa ctgtgggcca aacggcacaa catctattcc     2100

aatatattag gtttcctcgg tggtgtttcc tgggctatgc tagtagcaag aacttgccag     2160

ctttatccaa atgcaatagc atcaactctt gtacataaat ttttcttggt attttctaaa     2220

tgggaatggc caaatccagt gctattgaaa cagcctgaag aatgcaatct taatttgcct     2280

gtgtgggacc caagggtaaa ccccagtgat aggtaccatc ttatgcctat aattacacca     2340

gcatacccac agcagaactc cacgtacaat gtgtccgttt caacacggat ggtcatggtt     2400

gaggagttta aacaaggtct tgctatcaca gatgaaattt tgctgagtaa ggcagagtgg     2460

tccaaacttt ttgaagctcc aaacttcttt cagaagtaca agcattatat tgtacttcta     2520

gcaagtgcgc ccacggaaaa gcagcgtctg gaatgggtgg gcttggtgga atcaaaaatc     2580

cgcatcctgg ttggaagctt ggagaagaat gagtttatta cactggctca tgtgaatccc     2640

cagtcatttc cagcccccaa agaaagtcct gacagggaag aatttcgcac aatgtgggtg     2700

attgggttag tgtttaaaaa aactgaaaac tctgaaaatc tcagtgtcga cctcacctat     2760

gatatccagt ctttcacaga cacagtttat aggcaagcaa taaacagcaa aatgtttgag     2820

ttggatatga agattgcagc aatgcatgtg aagagaaagc aactccatca gctgctgcct     2880

agtcacgtgc ttcagaagag gaagaagcat tcaacagaag gagtcaagtt aacagctctg     2940

aatgacagca gccttgactt gtctatggac agtgataaca gcatgtctgt gccttcaccc     3000

accagtgcta tgaagaccag tccattgaat agttctggca gctcccaggg cagaaacagt     3060

cctgctccag ctgtgaccgc agcatctgtg accagcatcc aggcttctga ggtttctgta     3120

ccgcaagcaa attccagtga aagcccaggg ggtccatcga gcgaaagcat tcctcaaact     3180

gccacacagc cagccattgc cccaccacca aagcctacag tctccagagt tgtctcctca     3240

acacgactgg taaacccatc gcctagacct tcaggaaaca cagcaacaaa agtccctaat     3300

cctatagtag gagtcaagag aacgtccgcc cccaataaag aagaagcccc tagaaggacc     3360

aaaacagaag aggatgaaac aagtgaagat gctaactgtc ttgctttgag tggacatgat     3420

aaaacagaga caaaggaaca agttgatctg gagacaagtg cggttcaatc agaaactgtt     3480

ccggcatcgg cttctctgtt ggcctctcag aaaacatcca gtacagacct ttctgatatc     3540

cctgctctcc ctgcaaatcc tattcctgtt atcaagaact caataaaact gagactgaat     3600

cggggatcag gcccgcgacc cctccttgcc atccacccaa ccgaggcacg gcacaagcag     3660

aaaatagtgg cacccgttaa gcagactctc aactttgatc tcctgaagct tgccggcgac     3720

gtagagtcca accccggccc cgccagcctg gacaacctgg tggccagata ccagcggtgc     3780

ttcaacgacc agagcctgaa gaacagcacc atcgagctgg aaatccggtt ccagcagatc     3840

aacttcctgc tgttcaagac cgtgtacgag gccctggtcg cccaggaaat ccccagcacc     3900

atcagccaca gcatccggtg catcaagaag gtgcaccacg agaaccactg ccgggagaag     3960

atcctgccca gcgagaacct gtacttcaag aaacagcccc tgatgttctt caagttcagc     4020

gagcccgcca gcctgggctg taaagtgtcc ctggccatcg agcagcccat ccggaagttc     4080

atcctggaca gcagcgtgct ggtccggctg aagaaccgga ccaccttccg ggtgtccgag     4140

ctgtggaaga tcgagctgac catcgtgaag cagctgatgg gcagcgaggt gtcagccaag     4200

ctggccgcct tcaagaccct gctgttcgac acccccgagc agcagaccac caagaacatg     4260

atgaccctga tcaaccccga cgacgagtac ctgtacgaga tcgagatcga gtacaccggc     4320

aagcctgaga gcctgacagc cgccgacgtg atcaagatca agaacaccgt gctgacactg     4380

atcagcccca accacctgat gctgaccgcc taccaccagg ccatcgagtt tatcgccagc     4440

cacatcctga gcagcgagat cctgctggcc cggatcaaga gcggcaagtg gggcctgaag     4500

agactgctgc cccaggtcaa gtccatgacc aaggccgact acatgaagtt ctaccccccc     4560

gtgggctact acgtgaccga caaggccgac ggcatccggg gcattgccgt gatccaggac     4620

acccagatct acgtggtggc cgaccagctg tacagcctgg gcaccaccgg catcgagccc     4680

ctgaagccca ccatcctgga cggcgagttc atgcccgaga agaaagagtt ctacggcttt     4740

gacgtgatca tgtacgaggg caacctgctg acccagcagg gcttcgagac acggatcgag     4800

agcctgagca agggcatcaa ggtgctgcag gccttcaaca tcaaggccga gatgaagccc     4860

ttcatcagcc tgacctccgc cgaccccaac gtgctgctga agaatttcga gagcatcttc     4920

aagaagaaaa cccggcccta cagcatcgac ggcatcatcc tggtggagcc cggcaacagc     4980

tacctgaaca ccaacacctt caagtggaag cccacctggg acaacaccct ggactttctg     5040

gtccggaagt gccccgagtc cctgaacgtg cccgagtacg cccccaagaa gggcttcagc     5100

ctgcatctgc tgttcgtggg catcagcggc gagctgttta agaagctggc cctgaactgg     5160

tgccccggct acaccaagct gttccccgtg acccagcgga accagaacta cttccccgtg     5220

cagttccagc ccagcgactt ccccctggcc ttcctgtact accaccccga caccagcagc     5280

ttcagcaaca tcgatggcaa ggtgctggaa atgcggtgcc tgaagcggga gatcaactac     5340

gtgcgctggg agatcgtgaa gatccgggag gaccggcagc aggatctgaa aaccggcggc     5400

tacttcggca acgacttcaa gaccgccgag ctgacctggc tgaactacat ggaccccttc     5460

agcttcgagg aactggccaa gggacccagc ggcatgtact tcgctggcgc caagaccggc     5520

atctacagag cccagaccgc cctgatcagc ttcatcaagc aggaaatcat ccagaagatc     5580

agccaccaga gctgggtgat cgacctgggc atcggcaagg gccaggacct gggcagatac     5640

ctggacgccg gcgtgagaca cctggtcggc atcgataagg accagacagc cctggccgag     5700

ctggtgtacc ggaagttctc ccacgccacc accagacagc acaagcacgc caccaacatc     5760

tacgtgctgc accaggatct ggccgagcct gccaaagaaa tcagcgagaa agtgcaccag     5820

atctatggct tccccaaaga gggcgccagc agcatcgtgt ccaacctgtt catccactac     5880

ctgatgaaga acacccagca ggtcgagaac ctggctgtgc tgtgccacaa gctgctgcag     5940

cctggcggca tggtctggtt caccaccatg ctgggcgaac aggtgctgga actgctgcac     6000

gagaaccgga tcgaactgaa cgaagtgtgg gaggcccggg agaacgaggt ggtcaagttc     6060

gccatcaagc ggctgttcaa agaggacatc ctgcaggaaa ccggccagga aatcggcgtc     6120

ctgctgccct tcagcaacgg cgacttctac aatgagtacc tggtcaacac cgcctttctg     6180

atcaagattt tcaagcacca tggctttagc ctcgtgcaga agcagagctt caaggactgg     6240

atccccgagt tccagaactt cagcaagagc ctgtacaaga tcctgaccga ggccgacaag     6300

acctggacca gcctgttcgg cttcatctgc ctgcggaaga acggaggcgg gggaagtgga     6360

gggggcggca gtcaggacct gcacgccatc cagctgcagc tcgaagagga aatgttcaac     6420

ggcggcatca gaagattcga ggccgaccag cagagacaga tcgcctctgg caacgagagc     6480

gacaccgcct ggaatagaag gctgctgtct gagctgatcg cccctatggc cgaaggcatc     6540

caggcctaca aagaggaata cgagggcaag agaggcagag cccctagagc cctggccttc     6600

atcaactgtg tgggcaatga ggtggccgcc tacatcacca tgaagatcgt gatggacatg     6660

ctgaacaccg acgtgaccct gcaggccatt gccatgaacg tggccgacag aatcgaggac     6720

caggtccgat tcagcaagct ggaaggacac gccgccaagt acttcgagaa agtgaagaag     6780

tccctgaagg ccagcaagac caagagctac agacacgccc acaacgtggc cgtggtggcc     6840

gaaaaatctg tggccgatag ggacgccgac ttctctagat gggaggcctg gcctaaggac     6900

accctgctgc agatcggcat gaccctgctg gaaatcctgg aaaacagcgt gttcttcaac     6960

ggccagcccg tgttcctgag aaccctgagg acaaatggcg gcaagcacgg cgtgtactac     7020

ctgcagacat ctgagcacgt gggcgagtgg atcaccgcct tcaaagaaca tgtggcccag     7080

ctgagccctg cctatgcccc ttgtgtgatc cctcctagac cctgggtgtc ccctttcaat     7140

ggcggctttc acaccgagaa ggtggccagc agaatcagac tggtcaaggg caaccgggaa     7200

cacgtgcgga agctgaccaa gaaacagatg cccgccgtgt acaaggccgt gaatgctctg     7260

caggccacca agtggcaggt caacaaagag gtgctgcagg tcgtcgagga cgtgatcaga     7320

ctggatctgg gctacggcgt gccaagcttt aagcccctga tcgacagaga gaacaagccc     7380

gccaaccctg tgcccctgga atttcagcac ctgagaggcc gcgagctgaa agagatgctg     7440

acacctgaac agtggcaggc ctttatcaat tggaagggcg agtgcaccaa gctgtacacc     7500

gccgagacaa agaggggctc taagtctgcc gccacagtgc gaatggtcgg acaggccaga     7560

aagtacagcc agttcgacgc catctacttc gtgtacgccc tggacagccg gtctagagtg     7620

tatgcccaga gcagcacact gagcccccag tctaacgatc tgggaaaggc cctgctgaga     7680

ttcaccgagg gccagagact ggattctgcc gaagccctga agtggttcct ggtcaacggc     7740

gccaacaact ggggctggga caagaaaacc ttcgatgtgc ggaccgccaa cgtgctggat     7800

agcgagttcc aggacatgtg cagagatatc gccgccgacc ctctgacctt tacccagtgg     7860

gtcaacgccg atagccccta tggattcctg gcctggtgct tcgagtacgc cagatacctg     7920

gacgccctgg atgagggaac ccaggatcag ttcatgaccc atctgcccgt gcaccaggat     7980

ggctcttgtt ctggcatcca gcactacagc gccatgctga gcgatgccgt gggagccaaa     8040

gccgtgaacc tgaagcctag cgacagcccc caggatatct atggcgctgt ggcccaggtg     8100

gtcatccaga aaaactacgc ctacatgaac gccgaggacg ccgagacatt cacaagcgga     8160

agcgtgacac tgacaggcgc cgagctgaga tctatggcct ctgcctggga catgatcggc     8220

atcacacggg gcctgaccaa aaagcctgtg atgacactgc cctacggcag caccagactg     8280

acctgtagag aaagcgtgat cgactacatc gtggacctgg aagagaaaga ggcccagaga     8340

gccattgccg agggcagaac agccaatcct gtgcacccct tcgacaacga ccggaaggat     8400

agcctgacac ctagcgccgc ctacaactac atgaccgccc tgatctggcc cagcatctct     8460

gaagtggtca aggcccctat cgtggccatg aagatgatca gacagctggc cagattcgcc     8520

gccaagagaa atgagggcct ggaataccct ctgcccaccg gctttatcct gcagcagaaa     8580

atcatggcca ccgacatgct gcgggtgtcc acatgtctga tgggcgagat caagatgagc     8640

ctgcagatcg agacagacgt ggtggacgag acagccatga tgggagccgc cgctcctaat     8700

tttgtgcacg gacacgatgc cagccacctg atcctgaccg tgtgcgatct ggtggacaag     8760

ggcatcacta gcgtggccgt gatccacgat agctttggaa cacacgccgg cagaaccgcc     8820

gacctgagag attctctgcg ggaagagatg gtcaagatgt accagaacca caacgccctg     8880

cagaacctgc tggacgtgca cgaagaaaga tggctggtgg acaccggcat ccaggtgcca     8940

gaacagggag agttcgacct gaacgagatc ctggtgtccg actactgctt cgcctga        8997


<210>  38
<211>  2998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pC3P3-G3g plasmid

<400>  38

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Gly Ser Gly Pro Arg Pro Leu Leu Ala 
                165                 170                 175     


Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val 
            180                 185                 190         


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
        195                 200                 205             


Ser Asn Pro Gly Pro Ser Arg Arg Asn Lys Arg Ser Arg Arg Arg Arg 
    210                 215                 220                 


Lys Lys Pro Leu Asn Thr Ile Gln Pro Gly Pro Ser Lys Pro Ser Ala 
225                 230                 235                 240 


Gln Asp Glu Pro Ile Lys Ser Val Ser His His Ser Ser Lys Ile Gly 
                245                 250                 255     


Thr Asn Pro Met Leu Ala Phe Ile Leu Gly Gly Asn Glu Asp Leu Ser 
            260                 265                 270         


Asp Asp Ser Asp Trp Asp Glu Asp Phe Ser Leu Glu Asn Thr Leu Met 
        275                 280                 285             


Pro Leu Asn Glu Val Ser Leu Lys Gly Lys His Asp Ser Lys His Phe 
    290                 295                 300                 


Asn Lys Gly Phe Asp Asn Asn Thr Ala Leu His Glu Val Asn Thr Lys 
305                 310                 315                 320 


Trp Glu Ala Phe Tyr Ser Ser Val Lys Ile Arg Gln Arg Asp Val Lys 
                325                 330                 335     


Val Tyr Phe Ala Thr Asp Asp Ile Leu Ile Lys Val Arg Glu Ala Asp 
            340                 345                 350         


Asp Ile Asp Arg Lys Gly Pro Trp Glu Gln Ala Ala Val Asp Arg Leu 
        355                 360                 365             


Arg Phe Gln Arg Arg Ile Ala Asp Thr Glu Lys Ile Leu Ser Ala Val 
    370                 375                 380                 


Leu Leu Arg Lys Lys Leu Asn Pro Met Glu His Glu Gly Ser Gly Pro 
385                 390                 395                 400 


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
                405                 410                 415     


Ile Val Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu 
            420                 425                 430         


Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Asp Ala Gln Thr Arg Arg 
        435                 440                 445             


Arg Glu Arg Arg Ala Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Pro 
    450                 455                 460                 


Phe Pro Val Thr Thr Gln Gly Ser Gln Gln Thr Gln Pro Pro Gln Arg 
465                 470                 475                 480 


His Tyr Gly Ile Thr Ser Pro Ile Ser Leu Ala Ala Pro Lys Glu Thr 
                485                 490                 495     


Asp Cys Leu Leu Thr Gln Lys Leu Ile Glu Thr Leu Lys Pro Phe Gly 
            500                 505                 510         


Val Phe Glu Glu Glu Glu Glu Leu Gln Arg Arg Ile Leu Ile Leu Gly 
        515                 520                 525             


Lys Leu Asn Asn Leu Val Lys Glu Trp Ile Arg Glu Ile Ser Glu Ser 
    530                 535                 540                 


Lys Asn Leu Pro Gln Ser Val Ile Glu Asn Val Gly Gly Lys Ile Phe 
545                 550                 555                 560 


Thr Phe Gly Ser Tyr Arg Leu Gly Val His Thr Lys Gly Ala Asp Ile 
                565                 570                 575     


Asp Ala Leu Cys Val Ala Pro Arg His Val Asp Arg Ser Asp Phe Phe 
            580                 585                 590         


Thr Ser Phe Tyr Asp Lys Leu Lys Leu Gln Glu Glu Val Lys Asp Leu 
        595                 600                 605             


Arg Ala Val Glu Glu Ala Phe Val Pro Val Ile Lys Leu Cys Phe Asp 
    610                 615                 620                 


Gly Ile Glu Ile Asp Ile Leu Phe Ala Arg Leu Ala Leu Gln Thr Ile 
625                 630                 635                 640 


Pro Glu Asp Leu Asp Leu Arg Asp Asp Ser Leu Leu Lys Asn Leu Asp 
                645                 650                 655     


Ile Arg Cys Ile Arg Ser Leu Asn Gly Cys Arg Val Thr Asp Glu Ile 
            660                 665                 670         


Leu His Leu Val Pro Asn Ile Asp Asn Phe Arg Leu Thr Leu Arg Ala 
        675                 680                 685             


Ile Lys Leu Trp Ala Lys Arg His Asn Ile Tyr Ser Asn Ile Leu Gly 
    690                 695                 700                 


Phe Leu Gly Gly Val Ser Trp Ala Met Leu Val Ala Arg Thr Cys Gln 
705                 710                 715                 720 


Leu Tyr Pro Asn Ala Ile Ala Ser Thr Leu Val His Lys Phe Phe Leu 
                725                 730                 735     


Val Phe Ser Lys Trp Glu Trp Pro Asn Pro Val Leu Leu Lys Gln Pro 
            740                 745                 750         


Glu Glu Cys Asn Leu Asn Leu Pro Val Trp Asp Pro Arg Val Asn Pro 
        755                 760                 765             


Ser Asp Arg Tyr His Leu Met Pro Ile Ile Thr Pro Ala Tyr Pro Gln 
    770                 775                 780                 


Gln Asn Ser Thr Tyr Asn Val Ser Val Ser Thr Arg Met Val Met Val 
785                 790                 795                 800 


Glu Glu Phe Lys Gln Gly Leu Ala Ile Thr Asp Glu Ile Leu Leu Ser 
                805                 810                 815     


Lys Ala Glu Trp Ser Lys Leu Phe Glu Ala Pro Asn Phe Phe Gln Lys 
            820                 825                 830         


Tyr Lys His Tyr Ile Val Leu Leu Ala Ser Ala Pro Thr Glu Lys Gln 
        835                 840                 845             


Arg Leu Glu Trp Val Gly Leu Val Glu Ser Lys Ile Arg Ile Leu Val 
    850                 855                 860                 


Gly Ser Leu Glu Lys Asn Glu Phe Ile Thr Leu Ala His Val Asn Pro 
865                 870                 875                 880 


Gln Ser Phe Pro Ala Pro Lys Glu Ser Pro Asp Arg Glu Glu Phe Arg 
                885                 890                 895     


Thr Met Trp Val Ile Gly Leu Val Phe Lys Lys Thr Glu Asn Ser Glu 
            900                 905                 910         


Asn Leu Ser Val Asp Leu Thr Tyr Asp Ile Gln Ser Phe Thr Asp Thr 
        915                 920                 925             


Val Tyr Arg Gln Ala Ile Asn Ser Lys Met Phe Glu Leu Asp Met Lys 
    930                 935                 940                 


Ile Ala Ala Met His Val Lys Arg Lys Gln Leu His Gln Leu Leu Pro 
945                 950                 955                 960 


Ser His Val Leu Gln Lys Arg Lys Lys His Ser Thr Glu Gly Val Lys 
                965                 970                 975     


Leu Thr Ala Leu Asn Asp Ser Ser Leu Asp Leu Ser Met Asp Ser Asp 
            980                 985                 990         


Asn Ser Met Ser Val Pro Ser Pro  Thr Ser Ala Met Lys  Thr Ser Pro 
        995                 1000                 1005             


Leu Asn  Ser Ser Gly Ser Ser  Gln Gly Arg Asn Ser  Pro Ala Pro 
    1010                 1015                 1020             


Ala Val  Thr Ala Ala Ser Val  Thr Ser Ile Gln Ala  Ser Glu Val 
    1025                 1030                 1035             


Ser Val  Pro Gln Ala Asn Ser  Ser Glu Ser Pro Gly  Gly Pro Ser 
    1040                 1045                 1050             


Ser Glu  Ser Ile Pro Gln Thr  Ala Thr Gln Pro Ala  Ile Ala Pro 
    1055                 1060                 1065             


Pro Pro  Lys Pro Thr Val Ser  Arg Val Val Ser Ser  Thr Arg Leu 
    1070                 1075                 1080             


Val Asn  Pro Ser Pro Arg Pro  Ser Gly Asn Thr Ala  Thr Lys Val 
    1085                 1090                 1095             


Pro Asn  Pro Ile Val Gly Val  Lys Arg Thr Ser Ala  Pro Asn Lys 
    1100                 1105                 1110             


Glu Glu  Ala Pro Arg Arg Thr  Lys Thr Glu Glu Asp  Glu Thr Ser 
    1115                 1120                 1125             


Glu Asp  Ala Asn Cys Leu Ala  Leu Ser Gly His Asp  Lys Thr Glu 
    1130                 1135                 1140             


Thr Lys  Glu Gln Val Asp Leu  Glu Thr Ser Ala Val  Gln Ser Glu 
    1145                 1150                 1155             


Thr Val  Pro Ala Ser Ala Ser  Leu Leu Ala Ser Gln  Lys Thr Ser 
    1160                 1165                 1170             


Ser Thr  Asp Leu Ser Asp Ile  Pro Ala Leu Pro Ala  Asn Pro Ile 
    1175                 1180                 1185             


Pro Val  Ile Lys Asn Ser Ile  Lys Leu Arg Leu Asn  Arg Gly Ser 
    1190                 1195                 1200             


Gly Pro  Arg Pro Leu Leu Ala  Ile His Pro Thr Glu  Ala Arg His 
    1205                 1210                 1215             


Lys Gln  Lys Ile Val Ala Pro  Val Lys Gln Thr Leu  Asn Phe Asp 
    1220                 1225                 1230             


Leu Leu  Lys Leu Ala Gly Asp  Val Glu Ser Asn Pro  Gly Pro Ala 
    1235                 1240                 1245             


Ser Leu  Asp Asn Leu Val Ala  Arg Tyr Gln Arg Cys  Phe Asn Asp 
    1250                 1255                 1260             


Gln Ser  Leu Lys Asn Ser Thr  Ile Glu Leu Glu Ile  Arg Phe Gln 
    1265                 1270                 1275             


Gln Ile  Asn Phe Leu Leu Phe  Lys Thr Val Tyr Glu  Ala Leu Val 
    1280                 1285                 1290             


Ala Gln  Glu Ile Pro Ser Thr  Ile Ser His Ser Ile  Arg Cys Ile 
    1295                 1300                 1305             


Lys Lys  Val His His Glu Asn  His Cys Arg Glu Lys  Ile Leu Pro 
    1310                 1315                 1320             


Ser Glu  Asn Leu Tyr Phe Lys  Lys Gln Pro Leu Met  Phe Phe Lys 
    1325                 1330                 1335             


Phe Ser  Glu Pro Ala Ser Leu  Gly Cys Lys Val Ser  Leu Ala Ile 
    1340                 1345                 1350             


Glu Gln  Pro Ile Arg Lys Phe  Ile Leu Asp Ser Ser  Val Leu Val 
    1355                 1360                 1365             


Arg Leu  Lys Asn Arg Thr Thr  Phe Arg Val Ser Glu  Leu Trp Lys 
    1370                 1375                 1380             


Ile Glu  Leu Thr Ile Val Lys  Gln Leu Met Gly Ser  Glu Val Ser 
    1385                 1390                 1395             


Ala Lys  Leu Ala Ala Phe Lys  Thr Leu Leu Phe Asp  Thr Pro Glu 
    1400                 1405                 1410             


Gln Gln  Thr Thr Lys Asn Met  Met Thr Leu Ile Asn  Pro Asp Asp 
    1415                 1420                 1425             


Glu Tyr  Leu Tyr Glu Ile Glu  Ile Glu Tyr Thr Gly  Lys Pro Glu 
    1430                 1435                 1440             


Ser Leu  Thr Ala Ala Asp Val  Ile Lys Ile Lys Asn  Thr Val Leu 
    1445                 1450                 1455             


Thr Leu  Ile Ser Pro Asn His  Leu Met Leu Thr Ala  Tyr His Gln 
    1460                 1465                 1470             


Ala Ile  Glu Phe Ile Ala Ser  His Ile Leu Ser Ser  Glu Ile Leu 
    1475                 1480                 1485             


Leu Ala  Arg Ile Lys Ser Gly  Lys Trp Gly Leu Lys  Arg Leu Leu 
    1490                 1495                 1500             


Pro Gln  Val Lys Ser Met Thr  Lys Ala Asp Tyr Met  Lys Phe Tyr 
    1505                 1510                 1515             


Pro Pro  Val Gly Tyr Tyr Val  Thr Asp Lys Ala Asp  Gly Ile Arg 
    1520                 1525                 1530             


Gly Ile  Ala Val Ile Gln Asp  Thr Gln Ile Tyr Val  Val Ala Asp 
    1535                 1540                 1545             


Gln Leu  Tyr Ser Leu Gly Thr  Thr Gly Ile Glu Pro  Leu Lys Pro 
    1550                 1555                 1560             


Thr Ile  Leu Asp Gly Glu Phe  Met Pro Glu Lys Lys  Glu Phe Tyr 
    1565                 1570                 1575             


Gly Phe  Asp Val Ile Met Tyr  Glu Gly Asn Leu Leu  Thr Gln Gln 
    1580                 1585                 1590             


Gly Phe  Glu Thr Arg Ile Glu  Ser Leu Ser Lys Gly  Ile Lys Val 
    1595                 1600                 1605             


Leu Gln  Ala Phe Asn Ile Lys  Ala Glu Met Lys Pro  Phe Ile Ser 
    1610                 1615                 1620             


Leu Thr  Ser Ala Asp Pro Asn  Val Leu Leu Lys Asn  Phe Glu Ser 
    1625                 1630                 1635             


Ile Phe  Lys Lys Lys Thr Arg  Pro Tyr Ser Ile Asp  Gly Ile Ile 
    1640                 1645                 1650             


Leu Val  Glu Pro Gly Asn Ser  Tyr Leu Asn Thr Asn  Thr Phe Lys 
    1655                 1660                 1665             


Trp Lys  Pro Thr Trp Asp Asn  Thr Leu Asp Phe Leu  Val Arg Lys 
    1670                 1675                 1680             


Cys Pro  Glu Ser Leu Asn Val  Pro Glu Tyr Ala Pro  Lys Lys Gly 
    1685                 1690                 1695             


Phe Ser  Leu His Leu Leu Phe  Val Gly Ile Ser Gly  Glu Leu Phe 
    1700                 1705                 1710             


Lys Lys  Leu Ala Leu Asn Trp  Cys Pro Gly Tyr Thr  Lys Leu Phe 
    1715                 1720                 1725             


Pro Val  Thr Gln Arg Asn Gln  Asn Tyr Phe Pro Val  Gln Phe Gln 
    1730                 1735                 1740             


Pro Ser  Asp Phe Pro Leu Ala  Phe Leu Tyr Tyr His  Pro Asp Thr 
    1745                 1750                 1755             


Ser Ser  Phe Ser Asn Ile Asp  Gly Lys Val Leu Glu  Met Arg Cys 
    1760                 1765                 1770             


Leu Lys  Arg Glu Ile Asn Tyr  Val Arg Trp Glu Ile  Val Lys Ile 
    1775                 1780                 1785             


Arg Glu  Asp Arg Gln Gln Asp  Leu Lys Thr Gly Gly  Tyr Phe Gly 
    1790                 1795                 1800             


Asn Asp  Phe Lys Thr Ala Glu  Leu Thr Trp Leu Asn  Tyr Met Asp 
    1805                 1810                 1815             


Pro Phe  Ser Phe Glu Glu Leu  Ala Lys Gly Pro Ser  Gly Met Tyr 
    1820                 1825                 1830             


Phe Ala  Gly Ala Lys Thr Gly  Ile Tyr Arg Ala Gln  Thr Ala Leu 
    1835                 1840                 1845             


Ile Ser  Phe Ile Lys Gln Glu  Ile Ile Gln Lys Ile  Ser His Gln 
    1850                 1855                 1860             


Ser Trp  Val Ile Asp Leu Gly  Ile Gly Lys Gly Gln  Asp Leu Gly 
    1865                 1870                 1875             


Arg Tyr  Leu Asp Ala Gly Val  Arg His Leu Val Gly  Ile Asp Lys 
    1880                 1885                 1890             


Asp Gln  Thr Ala Leu Ala Glu  Leu Val Tyr Arg Lys  Phe Ser His 
    1895                 1900                 1905             


Ala Thr  Thr Arg Gln His Lys  His Ala Thr Asn Ile  Tyr Val Leu 
    1910                 1915                 1920             


His Gln  Asp Leu Ala Glu Pro  Ala Lys Glu Ile Ser  Glu Lys Val 
    1925                 1930                 1935             


His Gln  Ile Tyr Gly Phe Pro  Lys Glu Gly Ala Ser  Ser Ile Val 
    1940                 1945                 1950             


Ser Asn  Leu Phe Ile His Tyr  Leu Met Lys Asn Thr  Gln Gln Val 
    1955                 1960                 1965             


Glu Asn  Leu Ala Val Leu Cys  His Lys Leu Leu Gln  Pro Gly Gly 
    1970                 1975                 1980             


Met Val  Trp Phe Thr Thr Met  Leu Gly Glu Gln Val  Leu Glu Leu 
    1985                 1990                 1995             


Leu His  Glu Asn Arg Ile Glu  Leu Asn Glu Val Trp  Glu Ala Arg 
    2000                 2005                 2010             


Glu Asn  Glu Val Val Lys Phe  Ala Ile Lys Arg Leu  Phe Lys Glu 
    2015                 2020                 2025             


Asp Ile  Leu Gln Glu Thr Gly  Gln Glu Ile Gly Val  Leu Leu Pro 
    2030                 2035                 2040             


Phe Ser  Asn Gly Asp Phe Tyr  Asn Glu Tyr Leu Val  Asn Thr Ala 
    2045                 2050                 2055             


Phe Leu  Ile Lys Ile Phe Lys  His His Gly Phe Ser  Leu Val Gln 
    2060                 2065                 2070             


Lys Gln  Ser Phe Lys Asp Trp  Ile Pro Glu Phe Gln  Asn Phe Ser 
    2075                 2080                 2085             


Lys Ser  Leu Tyr Lys Ile Leu  Thr Glu Ala Asp Lys  Thr Trp Thr 
    2090                 2095                 2100             


Ser Leu  Phe Gly Phe Ile Cys  Leu Arg Lys Asn Gly  Gly Gly Gly 
    2105                 2110                 2115             


Ser Gly  Gly Gly Gly Ser Gln  Asp Leu His Ala Ile  Gln Leu Gln 
    2120                 2125                 2130             


Leu Glu  Glu Glu Met Phe Asn  Gly Gly Ile Arg Arg  Phe Glu Ala 
    2135                 2140                 2145             


Asp Gln  Gln Arg Gln Ile Ala  Ser Gly Asn Glu Ser  Asp Thr Ala 
    2150                 2155                 2160             


Trp Asn  Arg Arg Leu Leu Ser  Glu Leu Ile Ala Pro  Met Ala Glu 
    2165                 2170                 2175             


Gly Ile  Gln Ala Tyr Lys Glu  Glu Tyr Glu Gly Lys  Arg Gly Arg 
    2180                 2185                 2190             


Ala Pro  Arg Ala Leu Ala Phe  Ile Asn Cys Val Gly  Asn Glu Val 
    2195                 2200                 2205             


Ala Ala  Tyr Ile Thr Met Lys  Ile Val Met Asp Met  Leu Asn Thr 
    2210                 2215                 2220             


Asp Val  Thr Leu Gln Ala Ile  Ala Met Asn Val Ala  Asp Arg Ile 
    2225                 2230                 2235             


Glu Asp  Gln Val Arg Phe Ser  Lys Leu Glu Gly His  Ala Ala Lys 
    2240                 2245                 2250             


Tyr Phe  Glu Lys Val Lys Lys  Ser Leu Lys Ala Ser  Lys Thr Lys 
    2255                 2260                 2265             


Ser Tyr  Arg His Ala His Asn  Val Ala Val Val Ala  Glu Lys Ser 
    2270                 2275                 2280             


Val Ala  Asp Arg Asp Ala Asp  Phe Ser Arg Trp Glu  Ala Trp Pro 
    2285                 2290                 2295             


Lys Asp  Thr Leu Leu Gln Ile  Gly Met Thr Leu Leu  Glu Ile Leu 
    2300                 2305                 2310             


Glu Asn  Ser Val Phe Phe Asn  Gly Gln Pro Val Phe  Leu Arg Thr 
    2315                 2320                 2325             


Leu Arg  Thr Asn Gly Gly Lys  His Gly Val Tyr Tyr  Leu Gln Thr 
    2330                 2335                 2340             


Ser Glu  His Val Gly Glu Trp  Ile Thr Ala Phe Lys  Glu His Val 
    2345                 2350                 2355             


Ala Gln  Leu Ser Pro Ala Tyr  Ala Pro Cys Val Ile  Pro Pro Arg 
    2360                 2365                 2370             


Pro Trp  Val Ser Pro Phe Asn  Gly Gly Phe His Thr  Glu Lys Val 
    2375                 2380                 2385             


Ala Ser  Arg Ile Arg Leu Val  Lys Gly Asn Arg Glu  His Val Arg 
    2390                 2395                 2400             


Lys Leu  Thr Lys Lys Gln Met  Pro Ala Val Tyr Lys  Ala Val Asn 
    2405                 2410                 2415             


Ala Leu  Gln Ala Thr Lys Trp  Gln Val Asn Lys Glu  Val Leu Gln 
    2420                 2425                 2430             


Val Val  Glu Asp Val Ile Arg  Leu Asp Leu Gly Tyr  Gly Val Pro 
    2435                 2440                 2445             


Ser Phe  Lys Pro Leu Ile Asp  Arg Glu Asn Lys Pro  Ala Asn Pro 
    2450                 2455                 2460             


Val Pro  Leu Glu Phe Gln His  Leu Arg Gly Arg Glu  Leu Lys Glu 
    2465                 2470                 2475             


Met Leu  Thr Pro Glu Gln Trp  Gln Ala Phe Ile Asn  Trp Lys Gly 
    2480                 2485                 2490             


Glu Cys  Thr Lys Leu Tyr Thr  Ala Glu Thr Lys Arg  Gly Ser Lys 
    2495                 2500                 2505             


Ser Ala  Ala Thr Val Arg Met  Val Gly Gln Ala Arg  Lys Tyr Ser 
    2510                 2515                 2520             


Gln Phe  Asp Ala Ile Tyr Phe  Val Tyr Ala Leu Asp  Ser Arg Ser 
    2525                 2530                 2535             


Arg Val  Tyr Ala Gln Ser Ser  Thr Leu Ser Pro Gln  Ser Asn Asp 
    2540                 2545                 2550             


Leu Gly  Lys Ala Leu Leu Arg  Phe Thr Glu Gly Gln  Arg Leu Asp 
    2555                 2560                 2565             


Ser Ala  Glu Ala Leu Lys Trp  Phe Leu Val Asn Gly  Ala Asn Asn 
    2570                 2575                 2580             


Trp Gly  Trp Asp Lys Lys Thr  Phe Asp Val Arg Thr  Ala Asn Val 
    2585                 2590                 2595             


Leu Asp  Ser Glu Phe Gln Asp  Met Cys Arg Asp Ile  Ala Ala Asp 
    2600                 2605                 2610             


Pro Leu  Thr Phe Thr Gln Trp  Val Asn Ala Asp Ser  Pro Tyr Gly 
    2615                 2620                 2625             


Phe Leu  Ala Trp Cys Phe Glu  Tyr Ala Arg Tyr Leu  Asp Ala Leu 
    2630                 2635                 2640             


Asp Glu  Gly Thr Gln Asp Gln  Phe Met Thr His Leu  Pro Val His 
    2645                 2650                 2655             


Gln Asp  Gly Ser Cys Ser Gly  Ile Gln His Tyr Ser  Ala Met Leu 
    2660                 2665                 2670             


Ser Asp  Ala Val Gly Ala Lys  Ala Val Asn Leu Lys  Pro Ser Asp 
    2675                 2680                 2685             


Ser Pro  Gln Asp Ile Tyr Gly  Ala Val Ala Gln Val  Val Ile Gln 
    2690                 2695                 2700             


Lys Asn  Tyr Ala Tyr Met Asn  Ala Glu Asp Ala Glu  Thr Phe Thr 
    2705                 2710                 2715             


Ser Gly  Ser Val Thr Leu Thr  Gly Ala Glu Leu Arg  Ser Met Ala 
    2720                 2725                 2730             


Ser Ala  Trp Asp Met Ile Gly  Ile Thr Arg Gly Leu  Thr Lys Lys 
    2735                 2740                 2745             


Pro Val  Met Thr Leu Pro Tyr  Gly Ser Thr Arg Leu  Thr Cys Arg 
    2750                 2755                 2760             


Glu Ser  Val Ile Asp Tyr Ile  Val Asp Leu Glu Glu  Lys Glu Ala 
    2765                 2770                 2775             


Gln Arg  Ala Ile Ala Glu Gly  Arg Thr Ala Asn Pro  Val His Pro 
    2780                 2785                 2790             


Phe Asp  Asn Asp Arg Lys Asp  Ser Leu Thr Pro Ser  Ala Ala Tyr 
    2795                 2800                 2805             


Asn Tyr  Met Thr Ala Leu Ile  Trp Pro Ser Ile Ser  Glu Val Val 
    2810                 2815                 2820             


Lys Ala  Pro Ile Val Ala Met  Lys Met Ile Arg Gln  Leu Ala Arg 
    2825                 2830                 2835             


Phe Ala  Ala Lys Arg Asn Glu  Gly Leu Glu Tyr Pro  Leu Pro Thr 
    2840                 2845                 2850             


Gly Phe  Ile Leu Gln Gln Lys  Ile Met Ala Thr Asp  Met Leu Arg 
    2855                 2860                 2865             


Val Ser  Thr Cys Leu Met Gly  Glu Ile Lys Met Ser  Leu Gln Ile 
    2870                 2875                 2880             


Glu Thr  Asp Val Val Asp Glu  Thr Ala Met Met Gly  Ala Ala Ala 
    2885                 2890                 2895             


Pro Asn  Phe Val His Gly His  Asp Ala Ser His Leu  Ile Leu Thr 
    2900                 2905                 2910             


Val Cys  Asp Leu Val Asp Lys  Gly Ile Thr Ser Val  Ala Val Ile 
    2915                 2920                 2925             


His Asp  Ser Phe Gly Thr His  Ala Gly Arg Thr Ala  Asp Leu Arg 
    2930                 2935                 2940             


Asp Ser  Leu Arg Glu Glu Met  Val Lys Met Tyr Gln  Asn His Asn 
    2945                 2950                 2955             


Ala Leu  Gln Asn Leu Leu Asp  Val His Glu Glu Arg  Trp Leu Val 
    2960                 2965                 2970             


Asp Thr  Gly Ile Gln Val Pro  Glu Gln Gly Glu Phe  Asp Leu Asn 
    2975                 2980                 2985             


Glu Ile  Leu Val Ser Asp Tyr  Cys Phe Ala 
    2990                 2995             


<210>  39
<211>  8889
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pC3P3-G3h plasmid

<400>  39
atggatgctc agaccagacg cagagaacgg cgggcagaga agcaggcaca gtggaaggcc       60

gctaatccgt ttccagttac aacgcaggga tcacaacaaa cgcagccacc acagaggcac      120

tatggcatta cctctcctat cagcttagcg gcccccaagg agactgactg cctactcaca      180

cagaagctca tcgagacgct gaagcccttt ggggtttttg aagaagaaga ggaactgcag      240

cgcaggattt taattttggg aaaattaaat aacctggtga aagaatggat tcgagaaatc      300

agtgaaagca agaatctccc acaatctgta attgaaaatg ttggagggaa gatttttaca      360

tttggatctt acagactagg agtccacacg aaaggtgctg atattgatgc gttgtgtgtt      420

gcaccaagac atgttgatcg aagtgacttt ttcacctcat tctatgataa attgaaatta      480

caagaagaag tgaaagattt aagagctgtt gaagaggcat ttgtaccagt tatcaaactc      540

tgttttgatg gaatagagat tgatattttg tttgcaagat tagcactgca gactattcca      600

gaagatttgg acctacgaga tgacagtctg cttaaaaacc tagatataag atgcataaga      660

agccttaatg gttgcagggt aaccgatgaa attttacatc tagtaccaaa cattgacaac      720

ttcaggttaa ctctgagagc catcaaactg tgggccaaac ggcacaacat ctattccaat      780

atattaggtt tcctcggtgg tgtttcctgg gctatgctag tagcaagaac ttgccagctt      840

tatccaaatg caatagcatc aactcttgta cataaatttt tcttggtatt ttctaaatgg      900

gaatggccaa atccagtgct attgaaacag cctgaagaat gcaatcttaa tttgcctgtg      960

tgggacccaa gggtaaaccc cagtgatagg taccatctta tgcctataat tacaccagca     1020

tacccacagc agaactccac gtacaatgtg tccgtttcaa cacggatggt catggttgag     1080

gagtttaaac aaggtcttgc tatcacagat gaaattttgc tgagtaaggc agagtggtcc     1140

aaactttttg aagctccaaa cttctttcag aagtacaagc attatattgt acttctagca     1200

agtgcgccca cggaaaagca gcgtctggaa tgggtgggct tggtggaatc aaaaatccgc     1260

atcctggttg gaagcttgga gaagaatgag tttattacac tggctcatgt gaatccccag     1320

tcatttccag cccccaaaga aagtcctgac agggaagaat ttcgcacaat gtgggtgatt     1380

gggttagtgt ttaaaaaaac tgaaaactct gaaaatctca gtgtcgacct cacctatgat     1440

atccagtctt tcacagacac agtttatagg caagcaataa acagcaaaat gtttgagttg     1500

gatatgaaga ttgcagcaat gcatgtgaag agaaagcaac tccatcagct gctgcctagt     1560

cacgtgcttc agaagaggaa gaagcattca acagaaggag tcaagttaac agctctgaat     1620

gacagcagcc ttgacttgtc tatggacagt gataacagca tgtctgtgcc ttcacccacc     1680

agtgctatga agaccagtcc attgaatagt tctggcagct cccagggcag aaacagtcct     1740

gctccagctg tgaccgcagc atctgtgacc agcatccagg cttctgaggt ttctgtaccg     1800

caagcaaatt ccagtgaaag cccagggggt ccatcgagcg aaagcattcc tcaaactgcc     1860

acacagccag ccattgcccc accaccaaag cctacagtct ccagagttgt ctcctcaaca     1920

cgactggtaa acccatcgcc tagaccttca ggaaacacag caacaaaagt ccctaatcct     1980

atagtaggag tcaagagaac gtccgccccc aataaagaag aagcccctag aaggaccaaa     2040

acagaagagg atgaaacaag tgaagatgct aactgtcttg ctttgagtgg acatgataaa     2100

acagagacaa aggaacaagt tgatctggag acaagtgcgg ttcaatcaga aactgttccg     2160

gcatcggctt ctctgttggc ctctcagaaa acatccagta cagacctttc tgatatccct     2220

gctctccctg caaatcctat tcctgttatc aagaactcaa taaaactgag actgaatcgg     2280

ggatcaggcc cgcgacccct ccttgccatc cacccaaccg aggcacggca caagcagaaa     2340

atagtggcac ccgttaagca gactctcaac tttgatctcc tgaagcttgc cggcgacgta     2400

gagtccaacc ccggccccgc tggcgatctg agcgccggtt ttttcatgga agaactcaat     2460

acttatagac aaaaacaggg agtggtcctt aagtaccagg agcttcctaa ttcaggtccc     2520

ccccacgatc gaagattcac gtttcaggtg atcatcgatg gcagagaatt ccccgaaggc     2580

gagggacgct caaagaaaga ggctaagaat gctgcggcca agcttgccgt cgaaatcctg     2640

aataaggaaa aaaaggcagt tagcccgttg ctgttgacca ccacgaattc gtcagaagga     2700

ctatctatgg gcaactacat agggttgatt aacaggatcg cccagaaaaa acggcttacc     2760

gttaattatg agcaatgcgc tagtggtgtg cacggcccgg aagggttcca ttacaaatgc     2820

aaaatgggtc agaaggagta cagcattggg accggcagta caaaacagga agcaaagcag     2880

ctggccgcca agctagcata tcttcagatt ctgtccggag gaggaggctc tggtggtggc     2940

gggagcagcc ggcggaacaa gcggagccgg cggcggcgga agaagcccct gaacaccatc     3000

cagcccggcc ccagcaagcc cagcgcccag gacgagccca tcaagagcgt gagccaccac     3060

agcagcaaga tcggcaccaa ccccatgctg gccttcatcc tgggcggcaa cgaggacctg     3120

agcgacgaca gcgactggga cgaggacttc agcctggaga acaccctgat gcccctgaac     3180

gaggtgagcc tgaagggcaa gcacgacagc aagcacttca acaagggctt cgacaacaac     3240

accgccctgc acgaggtgaa caccaagtgg gaggccttct acagcagcgt gaagatccgg     3300

cagcgggacg tgaaggtgta cttcgccacc gacgacatcc tgatcaaggt gcgggaggcc     3360

gacgacatcg accggaaggg cccctgggag caggccgccg tggaccggct gcggttccag     3420

cggcggatcg ccgacaccga gaagatcctg agcgccgtgc tgctgcggaa gaagctgaac     3480

cccatggagc acgagggatc aggcccgcga cccctccttg ccatccaccc aaccgaggca     3540

cggcacaagc agaaaatagt ggcacccgtt aagcagactc tcaactttga tctcctgaag     3600

cttgccggcg acgtagagtc caaccccggc cccgccagcc tggacaacct ggtggccaga     3660

taccagcggt gcttcaacga ccagagcctg aagaacagca ccatcgagct ggaaatccgg     3720

ttccagcaga tcaacttcct gctgttcaag accgtgtacg aggccctggt cgcccaggaa     3780

atccccagca ccatcagcca cagcatccgg tgcatcaaga aggtgcacca cgagaaccac     3840

tgccgggaga agatcctgcc cagcgagaac ctgtacttca agaaacagcc cctgatgttc     3900

ttcaagttca gcgagcccgc cagcctgggc tgtaaagtgt ccctggccat cgagcagccc     3960

atccggaagt tcatcctgga cagcagcgtg ctggtccggc tgaagaaccg gaccaccttc     4020

cgggtgtccg agctgtggaa gatcgagctg accatcgtga agcagctgat gggcagcgag     4080

gtgtcagcca agctggccgc cttcaagacc ctgctgttcg acacccccga gcagcagacc     4140

accaagaaca tgatgaccct gatcaacccc gacgacgagt acctgtacga gatcgagatc     4200

gagtacaccg gcaagcctga gagcctgaca gccgccgacg tgatcaagat caagaacacc     4260

gtgctgacac tgatcagccc caaccacctg atgctgaccg cctaccacca ggccatcgag     4320

tttatcgcca gccacatcct gagcagcgag atcctgctgg cccggatcaa gagcggcaag     4380

tggggcctga agagactgct gccccaggtc aagtccatga ccaaggccga ctacatgaag     4440

ttctaccccc ccgtgggcta ctacgtgacc gacaaggccg acggcatccg gggcattgcc     4500

gtgatccagg acacccagat ctacgtggtg gccgaccagc tgtacagcct gggcaccacc     4560

ggcatcgagc ccctgaagcc caccatcctg gacggcgagt tcatgcccga gaagaaagag     4620

ttctacggct ttgacgtgat catgtacgag ggcaacctgc tgacccagca gggcttcgag     4680

acacggatcg agagcctgag caagggcatc aaggtgctgc aggccttcaa catcaaggcc     4740

gagatgaagc ccttcatcag cctgacctcc gccgacccca acgtgctgct gaagaatttc     4800

gagagcatct tcaagaagaa aacccggccc tacagcatcg acggcatcat cctggtggag     4860

cccggcaaca gctacctgaa caccaacacc ttcaagtgga agcccacctg ggacaacacc     4920

ctggactttc tggtccggaa gtgccccgag tccctgaacg tgcccgagta cgcccccaag     4980

aagggcttca gcctgcatct gctgttcgtg ggcatcagcg gcgagctgtt taagaagctg     5040

gccctgaact ggtgccccgg ctacaccaag ctgttccccg tgacccagcg gaaccagaac     5100

tacttccccg tgcagttcca gcccagcgac ttccccctgg ccttcctgta ctaccacccc     5160

gacaccagca gcttcagcaa catcgatggc aaggtgctgg aaatgcggtg cctgaagcgg     5220

gagatcaact acgtgcgctg ggagatcgtg aagatccggg aggaccggca gcaggatctg     5280

aaaaccggcg gctacttcgg caacgacttc aagaccgccg agctgacctg gctgaactac     5340

atggacccct tcagcttcga ggaactggcc aagggaccca gcggcatgta cttcgctggc     5400

gccaagaccg gcatctacag agcccagacc gccctgatca gcttcatcaa gcaggaaatc     5460

atccagaaga tcagccacca gagctgggtg atcgacctgg gcatcggcaa gggccaggac     5520

ctgggcagat acctggacgc cggcgtgaga cacctggtcg gcatcgataa ggaccagaca     5580

gccctggccg agctggtgta ccggaagttc tcccacgcca ccaccagaca gcacaagcac     5640

gccaccaaca tctacgtgct gcaccaggat ctggccgagc ctgccaaaga aatcagcgag     5700

aaagtgcacc agatctatgg cttccccaaa gagggcgcca gcagcatcgt gtccaacctg     5760

ttcatccact acctgatgaa gaacacccag caggtcgaga acctggctgt gctgtgccac     5820

aagctgctgc agcctggcgg catggtctgg ttcaccacca tgctgggcga acaggtgctg     5880

gaactgctgc acgagaaccg gatcgaactg aacgaagtgt gggaggcccg ggagaacgag     5940

gtggtcaagt tcgccatcaa gcggctgttc aaagaggaca tcctgcagga aaccggccag     6000

gaaatcggcg tcctgctgcc cttcagcaac ggcgacttct acaatgagta cctggtcaac     6060

accgcctttc tgatcaagat tttcaagcac catggcttta gcctcgtgca gaagcagagc     6120

ttcaaggact ggatccccga gttccagaac ttcagcaaga gcctgtacaa gatcctgacc     6180

gaggccgaca agacctggac cagcctgttc ggcttcatct gcctgcggaa gaacggaggc     6240

gggggaagtg gagggggcgg cagtcaggac ctgcacgcca tccagctgca gctcgaagag     6300

gaaatgttca acggcggcat cagaagattc gaggccgacc agcagagaca gatcgcctct     6360

ggcaacgaga gcgacaccgc ctggaataga aggctgctgt ctgagctgat cgcccctatg     6420

gccgaaggca tccaggccta caaagaggaa tacgagggca agagaggcag agcccctaga     6480

gccctggcct tcatcaactg tgtgggcaat gaggtggccg cctacatcac catgaagatc     6540

gtgatggaca tgctgaacac cgacgtgacc ctgcaggcca ttgccatgaa cgtggccgac     6600

agaatcgagg accaggtccg attcagcaag ctggaaggac acgccgccaa gtacttcgag     6660

aaagtgaaga agtccctgaa ggccagcaag accaagagct acagacacgc ccacaacgtg     6720

gccgtggtgg ccgaaaaatc tgtggccgat agggacgccg acttctctag atgggaggcc     6780

tggcctaagg acaccctgct gcagatcggc atgaccctgc tggaaatcct ggaaaacagc     6840

gtgttcttca acggccagcc cgtgttcctg agaaccctga ggacaaatgg cggcaagcac     6900

ggcgtgtact acctgcagac atctgagcac gtgggcgagt ggatcaccgc cttcaaagaa     6960

catgtggccc agctgagccc tgcctatgcc ccttgtgtga tccctcctag accctgggtg     7020

tcccctttca atggcggctt tcacaccgag aaggtggcca gcagaatcag actggtcaag     7080

ggcaaccggg aacacgtgcg gaagctgacc aagaaacaga tgcccgccgt gtacaaggcc     7140

gtgaatgctc tgcaggccac caagtggcag gtcaacaaag aggtgctgca ggtcgtcgag     7200

gacgtgatca gactggatct gggctacggc gtgccaagct ttaagcccct gatcgacaga     7260

gagaacaagc ccgccaaccc tgtgcccctg gaatttcagc acctgagagg ccgcgagctg     7320

aaagagatgc tgacacctga acagtggcag gcctttatca attggaaggg cgagtgcacc     7380

aagctgtaca ccgccgagac aaagaggggc tctaagtctg ccgccacagt gcgaatggtc     7440

ggacaggcca gaaagtacag ccagttcgac gccatctact tcgtgtacgc cctggacagc     7500

cggtctagag tgtatgccca gagcagcaca ctgagccccc agtctaacga tctgggaaag     7560

gccctgctga gattcaccga gggccagaga ctggattctg ccgaagccct gaagtggttc     7620

ctggtcaacg gcgccaacaa ctggggctgg gacaagaaaa ccttcgatgt gcggaccgcc     7680

aacgtgctgg atagcgagtt ccaggacatg tgcagagata tcgccgccga ccctctgacc     7740

tttacccagt gggtcaacgc cgatagcccc tatggattcc tggcctggtg cttcgagtac     7800

gccagatacc tggacgccct ggatgaggga acccaggatc agttcatgac ccatctgccc     7860

gtgcaccagg atggctcttg ttctggcatc cagcactaca gcgccatgct gagcgatgcc     7920

gtgggagcca aagccgtgaa cctgaagcct agcgacagcc cccaggatat ctatggcgct     7980

gtggcccagg tggtcatcca gaaaaactac gcctacatga acgccgagga cgccgagaca     8040

ttcacaagcg gaagcgtgac actgacaggc gccgagctga gatctatggc ctctgcctgg     8100

gacatgatcg gcatcacacg gggcctgacc aaaaagcctg tgatgacact gccctacggc     8160

agcaccagac tgacctgtag agaaagcgtg atcgactaca tcgtggacct ggaagagaaa     8220

gaggcccaga gagccattgc cgagggcaga acagccaatc ctgtgcaccc cttcgacaac     8280

gaccggaagg atagcctgac acctagcgcc gcctacaact acatgaccgc cctgatctgg     8340

cccagcatct ctgaagtggt caaggcccct atcgtggcca tgaagatgat cagacagctg     8400

gccagattcg ccgccaagag aaatgagggc ctggaatacc ctctgcccac cggctttatc     8460

ctgcagcaga aaatcatggc caccgacatg ctgcgggtgt ccacatgtct gatgggcgag     8520

atcaagatga gcctgcagat cgagacagac gtggtggacg agacagccat gatgggagcc     8580

gccgctccta attttgtgca cggacacgat gccagccacc tgatcctgac cgtgtgcgat     8640

ctggtggaca agggcatcac tagcgtggcc gtgatccacg atagctttgg aacacacgcc     8700

ggcagaaccg ccgacctgag agattctctg cgggaagaga tggtcaagat gtaccagaac     8760

cacaacgccc tgcagaacct gctggacgtg cacgaagaaa gatggctggt ggacaccggc     8820

atccaggtgc cagaacaggg agagttcgac ctgaacgaga tcctggtgtc cgactactgc     8880

ttcgcctga                                                             8889


<210>  40
<211>  2962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pC3P3-G3h plasmid

<400>  40

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn Pro Phe Pro Val Thr Thr Gln Gly Ser Gln 
            20                  25                  30          


Gln Thr Gln Pro Pro Gln Arg His Tyr Gly Ile Thr Ser Pro Ile Ser 
        35                  40                  45              


Leu Ala Ala Pro Lys Glu Thr Asp Cys Leu Leu Thr Gln Lys Leu Ile 
    50                  55                  60                  


Glu Thr Leu Lys Pro Phe Gly Val Phe Glu Glu Glu Glu Glu Leu Gln 
65                  70                  75                  80  


Arg Arg Ile Leu Ile Leu Gly Lys Leu Asn Asn Leu Val Lys Glu Trp 
                85                  90                  95      


Ile Arg Glu Ile Ser Glu Ser Lys Asn Leu Pro Gln Ser Val Ile Glu 
            100                 105                 110         


Asn Val Gly Gly Lys Ile Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val 
        115                 120                 125             


His Thr Lys Gly Ala Asp Ile Asp Ala Leu Cys Val Ala Pro Arg His 
    130                 135                 140                 


Val Asp Arg Ser Asp Phe Phe Thr Ser Phe Tyr Asp Lys Leu Lys Leu 
145                 150                 155                 160 


Gln Glu Glu Val Lys Asp Leu Arg Ala Val Glu Glu Ala Phe Val Pro 
                165                 170                 175     


Val Ile Lys Leu Cys Phe Asp Gly Ile Glu Ile Asp Ile Leu Phe Ala 
            180                 185                 190         


Arg Leu Ala Leu Gln Thr Ile Pro Glu Asp Leu Asp Leu Arg Asp Asp 
        195                 200                 205             


Ser Leu Leu Lys Asn Leu Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly 
    210                 215                 220                 


Cys Arg Val Thr Asp Glu Ile Leu His Leu Val Pro Asn Ile Asp Asn 
225                 230                 235                 240 


Phe Arg Leu Thr Leu Arg Ala Ile Lys Leu Trp Ala Lys Arg His Asn 
                245                 250                 255     


Ile Tyr Ser Asn Ile Leu Gly Phe Leu Gly Gly Val Ser Trp Ala Met 
            260                 265                 270         


Leu Val Ala Arg Thr Cys Gln Leu Tyr Pro Asn Ala Ile Ala Ser Thr 
        275                 280                 285             


Leu Val His Lys Phe Phe Leu Val Phe Ser Lys Trp Glu Trp Pro Asn 
    290                 295                 300                 


Pro Val Leu Leu Lys Gln Pro Glu Glu Cys Asn Leu Asn Leu Pro Val 
305                 310                 315                 320 


Trp Asp Pro Arg Val Asn Pro Ser Asp Arg Tyr His Leu Met Pro Ile 
                325                 330                 335     


Ile Thr Pro Ala Tyr Pro Gln Gln Asn Ser Thr Tyr Asn Val Ser Val 
            340                 345                 350         


Ser Thr Arg Met Val Met Val Glu Glu Phe Lys Gln Gly Leu Ala Ile 
        355                 360                 365             


Thr Asp Glu Ile Leu Leu Ser Lys Ala Glu Trp Ser Lys Leu Phe Glu 
    370                 375                 380                 


Ala Pro Asn Phe Phe Gln Lys Tyr Lys His Tyr Ile Val Leu Leu Ala 
385                 390                 395                 400 


Ser Ala Pro Thr Glu Lys Gln Arg Leu Glu Trp Val Gly Leu Val Glu 
                405                 410                 415     


Ser Lys Ile Arg Ile Leu Val Gly Ser Leu Glu Lys Asn Glu Phe Ile 
            420                 425                 430         


Thr Leu Ala His Val Asn Pro Gln Ser Phe Pro Ala Pro Lys Glu Ser 
        435                 440                 445             


Pro Asp Arg Glu Glu Phe Arg Thr Met Trp Val Ile Gly Leu Val Phe 
    450                 455                 460                 


Lys Lys Thr Glu Asn Ser Glu Asn Leu Ser Val Asp Leu Thr Tyr Asp 
465                 470                 475                 480 


Ile Gln Ser Phe Thr Asp Thr Val Tyr Arg Gln Ala Ile Asn Ser Lys 
                485                 490                 495     


Met Phe Glu Leu Asp Met Lys Ile Ala Ala Met His Val Lys Arg Lys 
            500                 505                 510         


Gln Leu His Gln Leu Leu Pro Ser His Val Leu Gln Lys Arg Lys Lys 
        515                 520                 525             


His Ser Thr Glu Gly Val Lys Leu Thr Ala Leu Asn Asp Ser Ser Leu 
    530                 535                 540                 


Asp Leu Ser Met Asp Ser Asp Asn Ser Met Ser Val Pro Ser Pro Thr 
545                 550                 555                 560 


Ser Ala Met Lys Thr Ser Pro Leu Asn Ser Ser Gly Ser Ser Gln Gly 
                565                 570                 575     


Arg Asn Ser Pro Ala Pro Ala Val Thr Ala Ala Ser Val Thr Ser Ile 
            580                 585                 590         


Gln Ala Ser Glu Val Ser Val Pro Gln Ala Asn Ser Ser Glu Ser Pro 
        595                 600                 605             


Gly Gly Pro Ser Ser Glu Ser Ile Pro Gln Thr Ala Thr Gln Pro Ala 
    610                 615                 620                 


Ile Ala Pro Pro Pro Lys Pro Thr Val Ser Arg Val Val Ser Ser Thr 
625                 630                 635                 640 


Arg Leu Val Asn Pro Ser Pro Arg Pro Ser Gly Asn Thr Ala Thr Lys 
                645                 650                 655     


Val Pro Asn Pro Ile Val Gly Val Lys Arg Thr Ser Ala Pro Asn Lys 
            660                 665                 670         


Glu Glu Ala Pro Arg Arg Thr Lys Thr Glu Glu Asp Glu Thr Ser Glu 
        675                 680                 685             


Asp Ala Asn Cys Leu Ala Leu Ser Gly His Asp Lys Thr Glu Thr Lys 
    690                 695                 700                 


Glu Gln Val Asp Leu Glu Thr Ser Ala Val Gln Ser Glu Thr Val Pro 
705                 710                 715                 720 


Ala Ser Ala Ser Leu Leu Ala Ser Gln Lys Thr Ser Ser Thr Asp Leu 
                725                 730                 735     


Ser Asp Ile Pro Ala Leu Pro Ala Asn Pro Ile Pro Val Ile Lys Asn 
            740                 745                 750         


Ser Ile Lys Leu Arg Leu Asn Arg Gly Ser Gly Pro Arg Pro Leu Leu 
        755                 760                 765             


Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro 
    770                 775                 780                 


Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
785                 790                 795                 800 


Glu Ser Asn Pro Gly Pro Ala Gly Asp Leu Ser Ala Gly Phe Phe Met 
                805                 810                 815     


Glu Glu Leu Asn Thr Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr 
            820                 825                 830         


Gln Glu Leu Pro Asn Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe 
        835                 840                 845             


Gln Val Ile Ile Asp Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser 
    850                 855                 860                 


Lys Lys Glu Ala Lys Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu 
865                 870                 875                 880 


Asn Lys Glu Lys Lys Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn 
                885                 890                 895     


Ser Ser Glu Gly Leu Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg 
            900                 905                 910         


Ile Ala Gln Lys Lys Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser 
        915                 920                 925             


Gly Val His Gly Pro Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln 
    930                 935                 940                 


Lys Glu Tyr Ser Ile Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln 
945                 950                 955                 960 


Leu Ala Ala Lys Leu Ala Tyr Leu Gln Ile Leu Ser Gly Gly Gly Gly 
                965                 970                 975     


Ser Gly Gly Gly Gly Ser Ser Arg Arg Asn Lys Arg Ser Arg Arg Arg 
            980                 985                 990         


Arg Lys Lys Pro Leu Asn Thr Ile  Gln Pro Gly Pro Ser  Lys Pro Ser 
        995                 1000                 1005             


Ala Gln  Asp Glu Pro Ile Lys  Ser Val Ser His His  Ser Ser Lys 
    1010                 1015                 1020             


Ile Gly  Thr Asn Pro Met Leu  Ala Phe Ile Leu Gly  Gly Asn Glu 
    1025                 1030                 1035             


Asp Leu  Ser Asp Asp Ser Asp  Trp Asp Glu Asp Phe  Ser Leu Glu 
    1040                 1045                 1050             


Asn Thr  Leu Met Pro Leu Asn  Glu Val Ser Leu Lys  Gly Lys His 
    1055                 1060                 1065             


Asp Ser  Lys His Phe Asn Lys  Gly Phe Asp Asn Asn  Thr Ala Leu 
    1070                 1075                 1080             


His Glu  Val Asn Thr Lys Trp  Glu Ala Phe Tyr Ser  Ser Val Lys 
    1085                 1090                 1095             


Ile Arg  Gln Arg Asp Val Lys  Val Tyr Phe Ala Thr  Asp Asp Ile 
    1100                 1105                 1110             


Leu Ile  Lys Val Arg Glu Ala  Asp Asp Ile Asp Arg  Lys Gly Pro 
    1115                 1120                 1125             


Trp Glu  Gln Ala Ala Val Asp  Arg Leu Arg Phe Gln  Arg Arg Ile 
    1130                 1135                 1140             


Ala Asp  Thr Glu Lys Ile Leu  Ser Ala Val Leu Leu  Arg Lys Lys 
    1145                 1150                 1155             


Leu Asn  Pro Met Glu His Glu  Gly Ser Gly Pro Arg  Pro Leu Leu 
    1160                 1165                 1170             


Ala Ile  His Pro Thr Glu Ala  Arg His Lys Gln Lys  Ile Val Ala 
    1175                 1180                 1185             


Pro Val  Lys Gln Thr Leu Asn  Phe Asp Leu Leu Lys  Leu Ala Gly 
    1190                 1195                 1200             


Asp Val  Glu Ser Asn Pro Gly  Pro Ala Ser Leu Asp  Asn Leu Val 
    1205                 1210                 1215             


Ala Arg  Tyr Gln Arg Cys Phe  Asn Asp Gln Ser Leu  Lys Asn Ser 
    1220                 1225                 1230             


Thr Ile  Glu Leu Glu Ile Arg  Phe Gln Gln Ile Asn  Phe Leu Leu 
    1235                 1240                 1245             


Phe Lys  Thr Val Tyr Glu Ala  Leu Val Ala Gln Glu  Ile Pro Ser 
    1250                 1255                 1260             


Thr Ile  Ser His Ser Ile Arg  Cys Ile Lys Lys Val  His His Glu 
    1265                 1270                 1275             


Asn His  Cys Arg Glu Lys Ile  Leu Pro Ser Glu Asn  Leu Tyr Phe 
    1280                 1285                 1290             


Lys Lys  Gln Pro Leu Met Phe  Phe Lys Phe Ser Glu  Pro Ala Ser 
    1295                 1300                 1305             


Leu Gly  Cys Lys Val Ser Leu  Ala Ile Glu Gln Pro  Ile Arg Lys 
    1310                 1315                 1320             


Phe Ile  Leu Asp Ser Ser Val  Leu Val Arg Leu Lys  Asn Arg Thr 
    1325                 1330                 1335             


Thr Phe  Arg Val Ser Glu Leu  Trp Lys Ile Glu Leu  Thr Ile Val 
    1340                 1345                 1350             


Lys Gln  Leu Met Gly Ser Glu  Val Ser Ala Lys Leu  Ala Ala Phe 
    1355                 1360                 1365             


Lys Thr  Leu Leu Phe Asp Thr  Pro Glu Gln Gln Thr  Thr Lys Asn 
    1370                 1375                 1380             


Met Met  Thr Leu Ile Asn Pro  Asp Asp Glu Tyr Leu  Tyr Glu Ile 
    1385                 1390                 1395             


Glu Ile  Glu Tyr Thr Gly Lys  Pro Glu Ser Leu Thr  Ala Ala Asp 
    1400                 1405                 1410             


Val Ile  Lys Ile Lys Asn Thr  Val Leu Thr Leu Ile  Ser Pro Asn 
    1415                 1420                 1425             


His Leu  Met Leu Thr Ala Tyr  His Gln Ala Ile Glu  Phe Ile Ala 
    1430                 1435                 1440             


Ser His  Ile Leu Ser Ser Glu  Ile Leu Leu Ala Arg  Ile Lys Ser 
    1445                 1450                 1455             


Gly Lys  Trp Gly Leu Lys Arg  Leu Leu Pro Gln Val  Lys Ser Met 
    1460                 1465                 1470             


Thr Lys  Ala Asp Tyr Met Lys  Phe Tyr Pro Pro Val  Gly Tyr Tyr 
    1475                 1480                 1485             


Val Thr  Asp Lys Ala Asp Gly  Ile Arg Gly Ile Ala  Val Ile Gln 
    1490                 1495                 1500             


Asp Thr  Gln Ile Tyr Val Val  Ala Asp Gln Leu Tyr  Ser Leu Gly 
    1505                 1510                 1515             


Thr Thr  Gly Ile Glu Pro Leu  Lys Pro Thr Ile Leu  Asp Gly Glu 
    1520                 1525                 1530             


Phe Met  Pro Glu Lys Lys Glu  Phe Tyr Gly Phe Asp  Val Ile Met 
    1535                 1540                 1545             


Tyr Glu  Gly Asn Leu Leu Thr  Gln Gln Gly Phe Glu  Thr Arg Ile 
    1550                 1555                 1560             


Glu Ser  Leu Ser Lys Gly Ile  Lys Val Leu Gln Ala  Phe Asn Ile 
    1565                 1570                 1575             


Lys Ala  Glu Met Lys Pro Phe  Ile Ser Leu Thr Ser  Ala Asp Pro 
    1580                 1585                 1590             


Asn Val  Leu Leu Lys Asn Phe  Glu Ser Ile Phe Lys  Lys Lys Thr 
    1595                 1600                 1605             


Arg Pro  Tyr Ser Ile Asp Gly  Ile Ile Leu Val Glu  Pro Gly Asn 
    1610                 1615                 1620             


Ser Tyr  Leu Asn Thr Asn Thr  Phe Lys Trp Lys Pro  Thr Trp Asp 
    1625                 1630                 1635             


Asn Thr  Leu Asp Phe Leu Val  Arg Lys Cys Pro Glu  Ser Leu Asn 
    1640                 1645                 1650             


Val Pro  Glu Tyr Ala Pro Lys  Lys Gly Phe Ser Leu  His Leu Leu 
    1655                 1660                 1665             


Phe Val  Gly Ile Ser Gly Glu  Leu Phe Lys Lys Leu  Ala Leu Asn 
    1670                 1675                 1680             


Trp Cys  Pro Gly Tyr Thr Lys  Leu Phe Pro Val Thr  Gln Arg Asn 
    1685                 1690                 1695             


Gln Asn  Tyr Phe Pro Val Gln  Phe Gln Pro Ser Asp  Phe Pro Leu 
    1700                 1705                 1710             


Ala Phe  Leu Tyr Tyr His Pro  Asp Thr Ser Ser Phe  Ser Asn Ile 
    1715                 1720                 1725             


Asp Gly  Lys Val Leu Glu Met  Arg Cys Leu Lys Arg  Glu Ile Asn 
    1730                 1735                 1740             


Tyr Val  Arg Trp Glu Ile Val  Lys Ile Arg Glu Asp  Arg Gln Gln 
    1745                 1750                 1755             


Asp Leu  Lys Thr Gly Gly Tyr  Phe Gly Asn Asp Phe  Lys Thr Ala 
    1760                 1765                 1770             


Glu Leu  Thr Trp Leu Asn Tyr  Met Asp Pro Phe Ser  Phe Glu Glu 
    1775                 1780                 1785             


Leu Ala  Lys Gly Pro Ser Gly  Met Tyr Phe Ala Gly  Ala Lys Thr 
    1790                 1795                 1800             


Gly Ile  Tyr Arg Ala Gln Thr  Ala Leu Ile Ser Phe  Ile Lys Gln 
    1805                 1810                 1815             


Glu Ile  Ile Gln Lys Ile Ser  His Gln Ser Trp Val  Ile Asp Leu 
    1820                 1825                 1830             


Gly Ile  Gly Lys Gly Gln Asp  Leu Gly Arg Tyr Leu  Asp Ala Gly 
    1835                 1840                 1845             


Val Arg  His Leu Val Gly Ile  Asp Lys Asp Gln Thr  Ala Leu Ala 
    1850                 1855                 1860             


Glu Leu  Val Tyr Arg Lys Phe  Ser His Ala Thr Thr  Arg Gln His 
    1865                 1870                 1875             


Lys His  Ala Thr Asn Ile Tyr  Val Leu His Gln Asp  Leu Ala Glu 
    1880                 1885                 1890             


Pro Ala  Lys Glu Ile Ser Glu  Lys Val His Gln Ile  Tyr Gly Phe 
    1895                 1900                 1905             


Pro Lys  Glu Gly Ala Ser Ser  Ile Val Ser Asn Leu  Phe Ile His 
    1910                 1915                 1920             


Tyr Leu  Met Lys Asn Thr Gln  Gln Val Glu Asn Leu  Ala Val Leu 
    1925                 1930                 1935             


Cys His  Lys Leu Leu Gln Pro  Gly Gly Met Val Trp  Phe Thr Thr 
    1940                 1945                 1950             


Met Leu  Gly Glu Gln Val Leu  Glu Leu Leu His Glu  Asn Arg Ile 
    1955                 1960                 1965             


Glu Leu  Asn Glu Val Trp Glu  Ala Arg Glu Asn Glu  Val Val Lys 
    1970                 1975                 1980             


Phe Ala  Ile Lys Arg Leu Phe  Lys Glu Asp Ile Leu  Gln Glu Thr 
    1985                 1990                 1995             


Gly Gln  Glu Ile Gly Val Leu  Leu Pro Phe Ser Asn  Gly Asp Phe 
    2000                 2005                 2010             


Tyr Asn  Glu Tyr Leu Val Asn  Thr Ala Phe Leu Ile  Lys Ile Phe 
    2015                 2020                 2025             


Lys His  His Gly Phe Ser Leu  Val Gln Lys Gln Ser  Phe Lys Asp 
    2030                 2035                 2040             


Trp Ile  Pro Glu Phe Gln Asn  Phe Ser Lys Ser Leu  Tyr Lys Ile 
    2045                 2050                 2055             


Leu Thr  Glu Ala Asp Lys Thr  Trp Thr Ser Leu Phe  Gly Phe Ile 
    2060                 2065                 2070             


Cys Leu  Arg Lys Asn Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    2075                 2080                 2085             


Gln Asp  Leu His Ala Ile Gln  Leu Gln Leu Glu Glu  Glu Met Phe 
    2090                 2095                 2100             


Asn Gly  Gly Ile Arg Arg Phe  Glu Ala Asp Gln Gln  Arg Gln Ile 
    2105                 2110                 2115             


Ala Ser  Gly Asn Glu Ser Asp  Thr Ala Trp Asn Arg  Arg Leu Leu 
    2120                 2125                 2130             


Ser Glu  Leu Ile Ala Pro Met  Ala Glu Gly Ile Gln  Ala Tyr Lys 
    2135                 2140                 2145             


Glu Glu  Tyr Glu Gly Lys Arg  Gly Arg Ala Pro Arg  Ala Leu Ala 
    2150                 2155                 2160             


Phe Ile  Asn Cys Val Gly Asn  Glu Val Ala Ala Tyr  Ile Thr Met 
    2165                 2170                 2175             


Lys Ile  Val Met Asp Met Leu  Asn Thr Asp Val Thr  Leu Gln Ala 
    2180                 2185                 2190             


Ile Ala  Met Asn Val Ala Asp  Arg Ile Glu Asp Gln  Val Arg Phe 
    2195                 2200                 2205             


Ser Lys  Leu Glu Gly His Ala  Ala Lys Tyr Phe Glu  Lys Val Lys 
    2210                 2215                 2220             


Lys Ser  Leu Lys Ala Ser Lys  Thr Lys Ser Tyr Arg  His Ala His 
    2225                 2230                 2235             


Asn Val  Ala Val Val Ala Glu  Lys Ser Val Ala Asp  Arg Asp Ala 
    2240                 2245                 2250             


Asp Phe  Ser Arg Trp Glu Ala  Trp Pro Lys Asp Thr  Leu Leu Gln 
    2255                 2260                 2265             


Ile Gly  Met Thr Leu Leu Glu  Ile Leu Glu Asn Ser  Val Phe Phe 
    2270                 2275                 2280             


Asn Gly  Gln Pro Val Phe Leu  Arg Thr Leu Arg Thr  Asn Gly Gly 
    2285                 2290                 2295             


Lys His  Gly Val Tyr Tyr Leu  Gln Thr Ser Glu His  Val Gly Glu 
    2300                 2305                 2310             


Trp Ile  Thr Ala Phe Lys Glu  His Val Ala Gln Leu  Ser Pro Ala 
    2315                 2320                 2325             


Tyr Ala  Pro Cys Val Ile Pro  Pro Arg Pro Trp Val  Ser Pro Phe 
    2330                 2335                 2340             


Asn Gly  Gly Phe His Thr Glu  Lys Val Ala Ser Arg  Ile Arg Leu 
    2345                 2350                 2355             


Val Lys  Gly Asn Arg Glu His  Val Arg Lys Leu Thr  Lys Lys Gln 
    2360                 2365                 2370             


Met Pro  Ala Val Tyr Lys Ala  Val Asn Ala Leu Gln  Ala Thr Lys 
    2375                 2380                 2385             


Trp Gln  Val Asn Lys Glu Val  Leu Gln Val Val Glu  Asp Val Ile 
    2390                 2395                 2400             


Arg Leu  Asp Leu Gly Tyr Gly  Val Pro Ser Phe Lys  Pro Leu Ile 
    2405                 2410                 2415             


Asp Arg  Glu Asn Lys Pro Ala  Asn Pro Val Pro Leu  Glu Phe Gln 
    2420                 2425                 2430             


His Leu  Arg Gly Arg Glu Leu  Lys Glu Met Leu Thr  Pro Glu Gln 
    2435                 2440                 2445             


Trp Gln  Ala Phe Ile Asn Trp  Lys Gly Glu Cys Thr  Lys Leu Tyr 
    2450                 2455                 2460             


Thr Ala  Glu Thr Lys Arg Gly  Ser Lys Ser Ala Ala  Thr Val Arg 
    2465                 2470                 2475             


Met Val  Gly Gln Ala Arg Lys  Tyr Ser Gln Phe Asp  Ala Ile Tyr 
    2480                 2485                 2490             


Phe Val  Tyr Ala Leu Asp Ser  Arg Ser Arg Val Tyr  Ala Gln Ser 
    2495                 2500                 2505             


Ser Thr  Leu Ser Pro Gln Ser  Asn Asp Leu Gly Lys  Ala Leu Leu 
    2510                 2515                 2520             


Arg Phe  Thr Glu Gly Gln Arg  Leu Asp Ser Ala Glu  Ala Leu Lys 
    2525                 2530                 2535             


Trp Phe  Leu Val Asn Gly Ala  Asn Asn Trp Gly Trp  Asp Lys Lys 
    2540                 2545                 2550             


Thr Phe  Asp Val Arg Thr Ala  Asn Val Leu Asp Ser  Glu Phe Gln 
    2555                 2560                 2565             


Asp Met  Cys Arg Asp Ile Ala  Ala Asp Pro Leu Thr  Phe Thr Gln 
    2570                 2575                 2580             


Trp Val  Asn Ala Asp Ser Pro  Tyr Gly Phe Leu Ala  Trp Cys Phe 
    2585                 2590                 2595             


Glu Tyr  Ala Arg Tyr Leu Asp  Ala Leu Asp Glu Gly  Thr Gln Asp 
    2600                 2605                 2610             


Gln Phe  Met Thr His Leu Pro  Val His Gln Asp Gly  Ser Cys Ser 
    2615                 2620                 2625             


Gly Ile  Gln His Tyr Ser Ala  Met Leu Ser Asp Ala  Val Gly Ala 
    2630                 2635                 2640             


Lys Ala  Val Asn Leu Lys Pro  Ser Asp Ser Pro Gln  Asp Ile Tyr 
    2645                 2650                 2655             


Gly Ala  Val Ala Gln Val Val  Ile Gln Lys Asn Tyr  Ala Tyr Met 
    2660                 2665                 2670             


Asn Ala  Glu Asp Ala Glu Thr  Phe Thr Ser Gly Ser  Val Thr Leu 
    2675                 2680                 2685             


Thr Gly  Ala Glu Leu Arg Ser  Met Ala Ser Ala Trp  Asp Met Ile 
    2690                 2695                 2700             


Gly Ile  Thr Arg Gly Leu Thr  Lys Lys Pro Val Met  Thr Leu Pro 
    2705                 2710                 2715             


Tyr Gly  Ser Thr Arg Leu Thr  Cys Arg Glu Ser Val  Ile Asp Tyr 
    2720                 2725                 2730             


Ile Val  Asp Leu Glu Glu Lys  Glu Ala Gln Arg Ala  Ile Ala Glu 
    2735                 2740                 2745             


Gly Arg  Thr Ala Asn Pro Val  His Pro Phe Asp Asn  Asp Arg Lys 
    2750                 2755                 2760             


Asp Ser  Leu Thr Pro Ser Ala  Ala Tyr Asn Tyr Met  Thr Ala Leu 
    2765                 2770                 2775             


Ile Trp  Pro Ser Ile Ser Glu  Val Val Lys Ala Pro  Ile Val Ala 
    2780                 2785                 2790             


Met Lys  Met Ile Arg Gln Leu  Ala Arg Phe Ala Ala  Lys Arg Asn 
    2795                 2800                 2805             


Glu Gly  Leu Glu Tyr Pro Leu  Pro Thr Gly Phe Ile  Leu Gln Gln 
    2810                 2815                 2820             


Lys Ile  Met Ala Thr Asp Met  Leu Arg Val Ser Thr  Cys Leu Met 
    2825                 2830                 2835             


Gly Glu  Ile Lys Met Ser Leu  Gln Ile Glu Thr Asp  Val Val Asp 
    2840                 2845                 2850             


Glu Thr  Ala Met Met Gly Ala  Ala Ala Pro Asn Phe  Val His Gly 
    2855                 2860                 2865             


His Asp  Ala Ser His Leu Ile  Leu Thr Val Cys Asp  Leu Val Asp 
    2870                 2875                 2880             


Lys Gly  Ile Thr Ser Val Ala  Val Ile His Asp Ser  Phe Gly Thr 
    2885                 2890                 2895             


His Ala  Gly Arg Thr Ala Asp  Leu Arg Asp Ser Leu  Arg Glu Glu 
    2900                 2905                 2910             


Met Val  Lys Met Tyr Gln Asn  His Asn Ala Leu Gln  Asn Leu Leu 
    2915                 2920                 2925             


Asp Val  His Glu Glu Arg Trp  Leu Val Asp Thr Gly  Ile Gln Val 
    2930                 2935                 2940             


Pro Glu  Gln Gly Glu Phe Asp  Leu Asn Glu Ile Leu  Val Ser Asp 
    2945                 2950                 2955             


Tyr Cys  Phe Ala 
    2960         


<210>  41
<211>  8997
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant DNA: open-reading frame from pC3P3-G3i plasmid

<400>  41
atggatgctc agaccagacg cagagaacgg cgggcagaga agcaggcaca gtggaaggcc       60

gctaatccgt ttccagttac aacgcaggga tcacaacaaa cgcagccacc acagaggcac      120

tatggcatta cctctcctat cagcttagcg gcccccaagg agactgactg cctactcaca      180

cagaagctca tcgagacgct gaagcccttt ggggtttttg aagaagaaga ggaactgcag      240

cgcaggattt taattttggg aaaattaaat aacctggtga aagaatggat tcgagaaatc      300

agtgaaagca agaatctccc acaatctgta attgaaaatg ttggagggaa gatttttaca      360

tttggatctt acagactagg agtccacacg aaaggtgctg atattgatgc gttgtgtgtt      420

gcaccaagac atgttgatcg aagtgacttt ttcacctcat tctatgataa attgaaatta      480

caagaagaag tgaaagattt aagagctgtt gaagaggcat ttgtaccagt tatcaaactc      540

tgttttgatg gaatagagat tgatattttg tttgcaagat tagcactgca gactattcca      600

gaagatttgg acctacgaga tgacagtctg cttaaaaacc tagatataag atgcataaga      660

agccttaatg gttgcagggt aaccgatgaa attttacatc tagtaccaaa cattgacaac      720

ttcaggttaa ctctgagagc catcaaactg tgggccaaac ggcacaacat ctattccaat      780

atattaggtt tcctcggtgg tgtttcctgg gctatgctag tagcaagaac ttgccagctt      840

tatccaaatg caatagcatc aactcttgta cataaatttt tcttggtatt ttctaaatgg      900

gaatggccaa atccagtgct attgaaacag cctgaagaat gcaatcttaa tttgcctgtg      960

tgggacccaa gggtaaaccc cagtgatagg taccatctta tgcctataat tacaccagca     1020

tacccacagc agaactccac gtacaatgtg tccgtttcaa cacggatggt catggttgag     1080

gagtttaaac aaggtcttgc tatcacagat gaaattttgc tgagtaaggc agagtggtcc     1140

aaactttttg aagctccaaa cttctttcag aagtacaagc attatattgt acttctagca     1200

agtgcgccca cggaaaagca gcgtctggaa tgggtgggct tggtggaatc aaaaatccgc     1260

atcctggttg gaagcttgga gaagaatgag tttattacac tggctcatgt gaatccccag     1320

tcatttccag cccccaaaga aagtcctgac agggaagaat ttcgcacaat gtgggtgatt     1380

gggttagtgt ttaaaaaaac tgaaaactct gaaaatctca gtgtcgacct cacctatgat     1440

atccagtctt tcacagacac agtttatagg caagcaataa acagcaaaat gtttgagttg     1500

gatatgaaga ttgcagcaat gcatgtgaag agaaagcaac tccatcagct gctgcctagt     1560

cacgtgcttc agaagaggaa gaagcattca acagaaggag tcaagttaac agctctgaat     1620

gacagcagcc ttgacttgtc tatggacagt gataacagca tgtctgtgcc ttcacccacc     1680

agtgctatga agaccagtcc attgaatagt tctggcagct cccagggcag aaacagtcct     1740

gctccagctg tgaccgcagc atctgtgacc agcatccagg cttctgaggt ttctgtaccg     1800

caagcaaatt ccagtgaaag cccagggggt ccatcgagcg aaagcattcc tcaaactgcc     1860

acacagccag ccattgcccc accaccaaag cctacagtct ccagagttgt ctcctcaaca     1920

cgactggtaa acccatcgcc tagaccttca ggaaacacag caacaaaagt ccctaatcct     1980

atagtaggag tcaagagaac gtccgccccc aataaagaag aagcccctag aaggaccaaa     2040

acagaagagg atgaaacaag tgaagatgct aactgtcttg ctttgagtgg acatgataaa     2100

acagagacaa aggaacaagt tgatctggag acaagtgcgg ttcaatcaga aactgttccg     2160

gcatcggctt ctctgttggc ctctcagaaa acatccagta cagacctttc tgatatccct     2220

gctctccctg caaatcctat tcctgttatc aagaactcaa taaaactgag actgaatcgg     2280

ggatcaggcc cgcgacccct ccttgccatc cacccaaccg aggcacggca caagcagaaa     2340

atagtggcac ccgttaagca gactctcaac tttgatctcc tgaagcttgc cggcgacgta     2400

gagtccaacc ccggccccgc tggcgatctg agcgccggtt ttttcatgga agaactcaat     2460

acttatagac aaaaacaggg agtggtcctt aagtaccagg agcttcctaa ttcaggtccc     2520

ccccacgatc gaagattcac gtttcaggtg atcatcgatg gcagagaatt ccccgaaggc     2580

gagggacgct caaagaaaga ggctaagaat gctgcggcca agcttgccgt cgaaatcctg     2640

aataaggaaa aaaaggcagt tagcccgttg ctgttgacca ccacgaattc gtcagaagga     2700

ctatctatgg gcaactacat agggttgatt aacaggatcg cccagaaaaa acggcttacc     2760

gttaattatg agcaatgcgc tagtggtgtg cacggcccgg aagggttcca ttacaaatgc     2820

aaaatgggtc agaaggagta cagcattggg accggcagta caaaacagga agcaaagcag     2880

ctggccgcca agctagcata tcttcagatt ctgtccggat caggcccgcg acccctcctt     2940

gccatccacc caaccgaggc acggcacaag cagaaaatag tggcacccgt taagcagact     3000

ctcaactttg atctcctgaa gcttgccggc gacgtagagt ccaaccccgg ccccagccgg     3060

cggaacaagc ggagccggcg gcggcggaag aagcccctga acaccatcca gcccggcccc     3120

agcaagccca gcgcccagga cgagcccatc aagagcgtga gccaccacag cagcaagatc     3180

ggcaccaacc ccatgctggc cttcatcctg ggcggcaacg aggacctgag cgacgacagc     3240

gactgggacg aggacttcag cctggagaac accctgatgc ccctgaacga ggtgagcctg     3300

aagggcaagc acgacagcaa gcacttcaac aagggcttcg acaacaacac cgccctgcac     3360

gaggtgaaca ccaagtggga ggccttctac agcagcgtga agatccggca gcgggacgtg     3420

aaggtgtact tcgccaccga cgacatcctg atcaaggtgc gggaggccga cgacatcgac     3480

cggaagggcc cctgggagca ggccgccgtg gaccggctgc ggttccagcg gcggatcgcc     3540

gacaccgaga agatcctgag cgccgtgctg ctgcggaaga agctgaaccc catggagcac     3600

gagggatcag gcccgcgacc cctccttgcc atccacccaa ccgaggcacg gcacaagcag     3660

aaaatagtgg cacccgttaa gcagactctc aactttgatc tcctgaagct tgccggcgac     3720

gtagagtcca accccggccc cgccagcctg gacaacctgg tggccagata ccagcggtgc     3780

ttcaacgacc agagcctgaa gaacagcacc atcgagctgg aaatccggtt ccagcagatc     3840

aacttcctgc tgttcaagac cgtgtacgag gccctggtcg cccaggaaat ccccagcacc     3900

atcagccaca gcatccggtg catcaagaag gtgcaccacg agaaccactg ccgggagaag     3960

atcctgccca gcgagaacct gtacttcaag aaacagcccc tgatgttctt caagttcagc     4020

gagcccgcca gcctgggctg taaagtgtcc ctggccatcg agcagcccat ccggaagttc     4080

atcctggaca gcagcgtgct ggtccggctg aagaaccgga ccaccttccg ggtgtccgag     4140

ctgtggaaga tcgagctgac catcgtgaag cagctgatgg gcagcgaggt gtcagccaag     4200

ctggccgcct tcaagaccct gctgttcgac acccccgagc agcagaccac caagaacatg     4260

atgaccctga tcaaccccga cgacgagtac ctgtacgaga tcgagatcga gtacaccggc     4320

aagcctgaga gcctgacagc cgccgacgtg atcaagatca agaacaccgt gctgacactg     4380

atcagcccca accacctgat gctgaccgcc taccaccagg ccatcgagtt tatcgccagc     4440

cacatcctga gcagcgagat cctgctggcc cggatcaaga gcggcaagtg gggcctgaag     4500

agactgctgc cccaggtcaa gtccatgacc aaggccgact acatgaagtt ctaccccccc     4560

gtgggctact acgtgaccga caaggccgac ggcatccggg gcattgccgt gatccaggac     4620

acccagatct acgtggtggc cgaccagctg tacagcctgg gcaccaccgg catcgagccc     4680

ctgaagccca ccatcctgga cggcgagttc atgcccgaga agaaagagtt ctacggcttt     4740

gacgtgatca tgtacgaggg caacctgctg acccagcagg gcttcgagac acggatcgag     4800

agcctgagca agggcatcaa ggtgctgcag gccttcaaca tcaaggccga gatgaagccc     4860

ttcatcagcc tgacctccgc cgaccccaac gtgctgctga agaatttcga gagcatcttc     4920

aagaagaaaa cccggcccta cagcatcgac ggcatcatcc tggtggagcc cggcaacagc     4980

tacctgaaca ccaacacctt caagtggaag cccacctggg acaacaccct ggactttctg     5040

gtccggaagt gccccgagtc cctgaacgtg cccgagtacg cccccaagaa gggcttcagc     5100

ctgcatctgc tgttcgtggg catcagcggc gagctgttta agaagctggc cctgaactgg     5160

tgccccggct acaccaagct gttccccgtg acccagcgga accagaacta cttccccgtg     5220

cagttccagc ccagcgactt ccccctggcc ttcctgtact accaccccga caccagcagc     5280

ttcagcaaca tcgatggcaa ggtgctggaa atgcggtgcc tgaagcggga gatcaactac     5340

gtgcgctggg agatcgtgaa gatccgggag gaccggcagc aggatctgaa aaccggcggc     5400

tacttcggca acgacttcaa gaccgccgag ctgacctggc tgaactacat ggaccccttc     5460

agcttcgagg aactggccaa gggacccagc ggcatgtact tcgctggcgc caagaccggc     5520

atctacagag cccagaccgc cctgatcagc ttcatcaagc aggaaatcat ccagaagatc     5580

agccaccaga gctgggtgat cgacctgggc atcggcaagg gccaggacct gggcagatac     5640

ctggacgccg gcgtgagaca cctggtcggc atcgataagg accagacagc cctggccgag     5700

ctggtgtacc ggaagttctc ccacgccacc accagacagc acaagcacgc caccaacatc     5760

tacgtgctgc accaggatct ggccgagcct gccaaagaaa tcagcgagaa agtgcaccag     5820

atctatggct tccccaaaga gggcgccagc agcatcgtgt ccaacctgtt catccactac     5880

ctgatgaaga acacccagca ggtcgagaac ctggctgtgc tgtgccacaa gctgctgcag     5940

cctggcggca tggtctggtt caccaccatg ctgggcgaac aggtgctgga actgctgcac     6000

gagaaccgga tcgaactgaa cgaagtgtgg gaggcccggg agaacgaggt ggtcaagttc     6060

gccatcaagc ggctgttcaa agaggacatc ctgcaggaaa ccggccagga aatcggcgtc     6120

ctgctgccct tcagcaacgg cgacttctac aatgagtacc tggtcaacac cgcctttctg     6180

atcaagattt tcaagcacca tggctttagc ctcgtgcaga agcagagctt caaggactgg     6240

atccccgagt tccagaactt cagcaagagc ctgtacaaga tcctgaccga ggccgacaag     6300

acctggacca gcctgttcgg cttcatctgc ctgcggaaga acggaggcgg gggaagtgga     6360

gggggcggca gtcaggacct gcacgccatc cagctgcagc tcgaagagga aatgttcaac     6420

ggcggcatca gaagattcga ggccgaccag cagagacaga tcgcctctgg caacgagagc     6480

gacaccgcct ggaatagaag gctgctgtct gagctgatcg cccctatggc cgaaggcatc     6540

caggcctaca aagaggaata cgagggcaag agaggcagag cccctagagc cctggccttc     6600

atcaactgtg tgggcaatga ggtggccgcc tacatcacca tgaagatcgt gatggacatg     6660

ctgaacaccg acgtgaccct gcaggccatt gccatgaacg tggccgacag aatcgaggac     6720

caggtccgat tcagcaagct ggaaggacac gccgccaagt acttcgagaa agtgaagaag     6780

tccctgaagg ccagcaagac caagagctac agacacgccc acaacgtggc cgtggtggcc     6840

gaaaaatctg tggccgatag ggacgccgac ttctctagat gggaggcctg gcctaaggac     6900

accctgctgc agatcggcat gaccctgctg gaaatcctgg aaaacagcgt gttcttcaac     6960

ggccagcccg tgttcctgag aaccctgagg acaaatggcg gcaagcacgg cgtgtactac     7020

ctgcagacat ctgagcacgt gggcgagtgg atcaccgcct tcaaagaaca tgtggcccag     7080

ctgagccctg cctatgcccc ttgtgtgatc cctcctagac cctgggtgtc ccctttcaat     7140

ggcggctttc acaccgagaa ggtggccagc agaatcagac tggtcaaggg caaccgggaa     7200

cacgtgcgga agctgaccaa gaaacagatg cccgccgtgt acaaggccgt gaatgctctg     7260

caggccacca agtggcaggt caacaaagag gtgctgcagg tcgtcgagga cgtgatcaga     7320

ctggatctgg gctacggcgt gccaagcttt aagcccctga tcgacagaga gaacaagccc     7380

gccaaccctg tgcccctgga atttcagcac ctgagaggcc gcgagctgaa agagatgctg     7440

acacctgaac agtggcaggc ctttatcaat tggaagggcg agtgcaccaa gctgtacacc     7500

gccgagacaa agaggggctc taagtctgcc gccacagtgc gaatggtcgg acaggccaga     7560

aagtacagcc agttcgacgc catctacttc gtgtacgccc tggacagccg gtctagagtg     7620

tatgcccaga gcagcacact gagcccccag tctaacgatc tgggaaaggc cctgctgaga     7680

ttcaccgagg gccagagact ggattctgcc gaagccctga agtggttcct ggtcaacggc     7740

gccaacaact ggggctggga caagaaaacc ttcgatgtgc ggaccgccaa cgtgctggat     7800

agcgagttcc aggacatgtg cagagatatc gccgccgacc ctctgacctt tacccagtgg     7860

gtcaacgccg atagccccta tggattcctg gcctggtgct tcgagtacgc cagatacctg     7920

gacgccctgg atgagggaac ccaggatcag ttcatgaccc atctgcccgt gcaccaggat     7980

ggctcttgtt ctggcatcca gcactacagc gccatgctga gcgatgccgt gggagccaaa     8040

gccgtgaacc tgaagcctag cgacagcccc caggatatct atggcgctgt ggcccaggtg     8100

gtcatccaga aaaactacgc ctacatgaac gccgaggacg ccgagacatt cacaagcgga     8160

agcgtgacac tgacaggcgc cgagctgaga tctatggcct ctgcctggga catgatcggc     8220

atcacacggg gcctgaccaa aaagcctgtg atgacactgc cctacggcag caccagactg     8280

acctgtagag aaagcgtgat cgactacatc gtggacctgg aagagaaaga ggcccagaga     8340

gccattgccg agggcagaac agccaatcct gtgcacccct tcgacaacga ccggaaggat     8400

agcctgacac ctagcgccgc ctacaactac atgaccgccc tgatctggcc cagcatctct     8460

gaagtggtca aggcccctat cgtggccatg aagatgatca gacagctggc cagattcgcc     8520

gccaagagaa atgagggcct ggaataccct ctgcccaccg gctttatcct gcagcagaaa     8580

atcatggcca ccgacatgct gcgggtgtcc acatgtctga tgggcgagat caagatgagc     8640

ctgcagatcg agacagacgt ggtggacgag acagccatga tgggagccgc cgctcctaat     8700

tttgtgcacg gacacgatgc cagccacctg atcctgaccg tgtgcgatct ggtggacaag     8760

ggcatcacta gcgtggccgt gatccacgat agctttggaa cacacgccgg cagaaccgcc     8820

gacctgagag attctctgcg ggaagagatg gtcaagatgt accagaacca caacgccctg     8880

cagaacctgc tggacgtgca cgaagaaaga tggctggtgg acaccggcat ccaggtgcca     8940

gaacagggag agttcgacct gaacgagatc ctggtgtccg actactgctt cgcctga        8997


<210>  42
<211>  2998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein encoded by pC3P3-G3i plasmid

<400>  42

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn Pro Phe Pro Val Thr Thr Gln Gly Ser Gln 
            20                  25                  30          


Gln Thr Gln Pro Pro Gln Arg His Tyr Gly Ile Thr Ser Pro Ile Ser 
        35                  40                  45              


Leu Ala Ala Pro Lys Glu Thr Asp Cys Leu Leu Thr Gln Lys Leu Ile 
    50                  55                  60                  


Glu Thr Leu Lys Pro Phe Gly Val Phe Glu Glu Glu Glu Glu Leu Gln 
65                  70                  75                  80  


Arg Arg Ile Leu Ile Leu Gly Lys Leu Asn Asn Leu Val Lys Glu Trp 
                85                  90                  95      


Ile Arg Glu Ile Ser Glu Ser Lys Asn Leu Pro Gln Ser Val Ile Glu 
            100                 105                 110         


Asn Val Gly Gly Lys Ile Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val 
        115                 120                 125             


His Thr Lys Gly Ala Asp Ile Asp Ala Leu Cys Val Ala Pro Arg His 
    130                 135                 140                 


Val Asp Arg Ser Asp Phe Phe Thr Ser Phe Tyr Asp Lys Leu Lys Leu 
145                 150                 155                 160 


Gln Glu Glu Val Lys Asp Leu Arg Ala Val Glu Glu Ala Phe Val Pro 
                165                 170                 175     


Val Ile Lys Leu Cys Phe Asp Gly Ile Glu Ile Asp Ile Leu Phe Ala 
            180                 185                 190         


Arg Leu Ala Leu Gln Thr Ile Pro Glu Asp Leu Asp Leu Arg Asp Asp 
        195                 200                 205             


Ser Leu Leu Lys Asn Leu Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly 
    210                 215                 220                 


Cys Arg Val Thr Asp Glu Ile Leu His Leu Val Pro Asn Ile Asp Asn 
225                 230                 235                 240 


Phe Arg Leu Thr Leu Arg Ala Ile Lys Leu Trp Ala Lys Arg His Asn 
                245                 250                 255     


Ile Tyr Ser Asn Ile Leu Gly Phe Leu Gly Gly Val Ser Trp Ala Met 
            260                 265                 270         


Leu Val Ala Arg Thr Cys Gln Leu Tyr Pro Asn Ala Ile Ala Ser Thr 
        275                 280                 285             


Leu Val His Lys Phe Phe Leu Val Phe Ser Lys Trp Glu Trp Pro Asn 
    290                 295                 300                 


Pro Val Leu Leu Lys Gln Pro Glu Glu Cys Asn Leu Asn Leu Pro Val 
305                 310                 315                 320 


Trp Asp Pro Arg Val Asn Pro Ser Asp Arg Tyr His Leu Met Pro Ile 
                325                 330                 335     


Ile Thr Pro Ala Tyr Pro Gln Gln Asn Ser Thr Tyr Asn Val Ser Val 
            340                 345                 350         


Ser Thr Arg Met Val Met Val Glu Glu Phe Lys Gln Gly Leu Ala Ile 
        355                 360                 365             


Thr Asp Glu Ile Leu Leu Ser Lys Ala Glu Trp Ser Lys Leu Phe Glu 
    370                 375                 380                 


Ala Pro Asn Phe Phe Gln Lys Tyr Lys His Tyr Ile Val Leu Leu Ala 
385                 390                 395                 400 


Ser Ala Pro Thr Glu Lys Gln Arg Leu Glu Trp Val Gly Leu Val Glu 
                405                 410                 415     


Ser Lys Ile Arg Ile Leu Val Gly Ser Leu Glu Lys Asn Glu Phe Ile 
            420                 425                 430         


Thr Leu Ala His Val Asn Pro Gln Ser Phe Pro Ala Pro Lys Glu Ser 
        435                 440                 445             


Pro Asp Arg Glu Glu Phe Arg Thr Met Trp Val Ile Gly Leu Val Phe 
    450                 455                 460                 


Lys Lys Thr Glu Asn Ser Glu Asn Leu Ser Val Asp Leu Thr Tyr Asp 
465                 470                 475                 480 


Ile Gln Ser Phe Thr Asp Thr Val Tyr Arg Gln Ala Ile Asn Ser Lys 
                485                 490                 495     


Met Phe Glu Leu Asp Met Lys Ile Ala Ala Met His Val Lys Arg Lys 
            500                 505                 510         


Gln Leu His Gln Leu Leu Pro Ser His Val Leu Gln Lys Arg Lys Lys 
        515                 520                 525             


His Ser Thr Glu Gly Val Lys Leu Thr Ala Leu Asn Asp Ser Ser Leu 
    530                 535                 540                 


Asp Leu Ser Met Asp Ser Asp Asn Ser Met Ser Val Pro Ser Pro Thr 
545                 550                 555                 560 


Ser Ala Met Lys Thr Ser Pro Leu Asn Ser Ser Gly Ser Ser Gln Gly 
                565                 570                 575     


Arg Asn Ser Pro Ala Pro Ala Val Thr Ala Ala Ser Val Thr Ser Ile 
            580                 585                 590         


Gln Ala Ser Glu Val Ser Val Pro Gln Ala Asn Ser Ser Glu Ser Pro 
        595                 600                 605             


Gly Gly Pro Ser Ser Glu Ser Ile Pro Gln Thr Ala Thr Gln Pro Ala 
    610                 615                 620                 


Ile Ala Pro Pro Pro Lys Pro Thr Val Ser Arg Val Val Ser Ser Thr 
625                 630                 635                 640 


Arg Leu Val Asn Pro Ser Pro Arg Pro Ser Gly Asn Thr Ala Thr Lys 
                645                 650                 655     


Val Pro Asn Pro Ile Val Gly Val Lys Arg Thr Ser Ala Pro Asn Lys 
            660                 665                 670         


Glu Glu Ala Pro Arg Arg Thr Lys Thr Glu Glu Asp Glu Thr Ser Glu 
        675                 680                 685             


Asp Ala Asn Cys Leu Ala Leu Ser Gly His Asp Lys Thr Glu Thr Lys 
    690                 695                 700                 


Glu Gln Val Asp Leu Glu Thr Ser Ala Val Gln Ser Glu Thr Val Pro 
705                 710                 715                 720 


Ala Ser Ala Ser Leu Leu Ala Ser Gln Lys Thr Ser Ser Thr Asp Leu 
                725                 730                 735     


Ser Asp Ile Pro Ala Leu Pro Ala Asn Pro Ile Pro Val Ile Lys Asn 
            740                 745                 750         


Ser Ile Lys Leu Arg Leu Asn Arg Gly Ser Gly Pro Arg Pro Leu Leu 
        755                 760                 765             


Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro 
    770                 775                 780                 


Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
785                 790                 795                 800 


Glu Ser Asn Pro Gly Pro Ala Gly Asp Leu Ser Ala Gly Phe Phe Met 
                805                 810                 815     


Glu Glu Leu Asn Thr Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr 
            820                 825                 830         


Gln Glu Leu Pro Asn Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe 
        835                 840                 845             


Gln Val Ile Ile Asp Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser 
    850                 855                 860                 


Lys Lys Glu Ala Lys Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu 
865                 870                 875                 880 


Asn Lys Glu Lys Lys Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn 
                885                 890                 895     


Ser Ser Glu Gly Leu Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg 
            900                 905                 910         


Ile Ala Gln Lys Lys Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser 
        915                 920                 925             


Gly Val His Gly Pro Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln 
    930                 935                 940                 


Lys Glu Tyr Ser Ile Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln 
945                 950                 955                 960 


Leu Ala Ala Lys Leu Ala Tyr Leu Gln Ile Leu Ser Gly Ser Gly Pro 
                965                 970                 975     


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            980                 985                 990         


Ile Val Ala Pro Val Lys Gln Thr  Leu Asn Phe Asp Leu  Leu Lys Leu 
        995                 1000                 1005             


Ala Gly  Asp Val Glu Ser Asn  Pro Gly Pro Ser Arg  Arg Asn Lys 
    1010                 1015                 1020             


Arg Ser  Arg Arg Arg Arg Lys  Lys Pro Leu Asn Thr  Ile Gln Pro 
    1025                 1030                 1035             


Gly Pro  Ser Lys Pro Ser Ala  Gln Asp Glu Pro Ile  Lys Ser Val 
    1040                 1045                 1050             


Ser His  His Ser Ser Lys Ile  Gly Thr Asn Pro Met  Leu Ala Phe 
    1055                 1060                 1065             


Ile Leu  Gly Gly Asn Glu Asp  Leu Ser Asp Asp Ser  Asp Trp Asp 
    1070                 1075                 1080             


Glu Asp  Phe Ser Leu Glu Asn  Thr Leu Met Pro Leu  Asn Glu Val 
    1085                 1090                 1095             


Ser Leu  Lys Gly Lys His Asp  Ser Lys His Phe Asn  Lys Gly Phe 
    1100                 1105                 1110             


Asp Asn  Asn Thr Ala Leu His  Glu Val Asn Thr Lys  Trp Glu Ala 
    1115                 1120                 1125             


Phe Tyr  Ser Ser Val Lys Ile  Arg Gln Arg Asp Val  Lys Val Tyr 
    1130                 1135                 1140             


Phe Ala  Thr Asp Asp Ile Leu  Ile Lys Val Arg Glu  Ala Asp Asp 
    1145                 1150                 1155             


Ile Asp  Arg Lys Gly Pro Trp  Glu Gln Ala Ala Val  Asp Arg Leu 
    1160                 1165                 1170             


Arg Phe  Gln Arg Arg Ile Ala  Asp Thr Glu Lys Ile  Leu Ser Ala 
    1175                 1180                 1185             


Val Leu  Leu Arg Lys Lys Leu  Asn Pro Met Glu His  Glu Gly Ser 
    1190                 1195                 1200             


Gly Pro  Arg Pro Leu Leu Ala  Ile His Pro Thr Glu  Ala Arg His 
    1205                 1210                 1215             


Lys Gln  Lys Ile Val Ala Pro  Val Lys Gln Thr Leu  Asn Phe Asp 
    1220                 1225                 1230             


Leu Leu  Lys Leu Ala Gly Asp  Val Glu Ser Asn Pro  Gly Pro Ala 
    1235                 1240                 1245             


Ser Leu  Asp Asn Leu Val Ala  Arg Tyr Gln Arg Cys  Phe Asn Asp 
    1250                 1255                 1260             


Gln Ser  Leu Lys Asn Ser Thr  Ile Glu Leu Glu Ile  Arg Phe Gln 
    1265                 1270                 1275             


Gln Ile  Asn Phe Leu Leu Phe  Lys Thr Val Tyr Glu  Ala Leu Val 
    1280                 1285                 1290             


Ala Gln  Glu Ile Pro Ser Thr  Ile Ser His Ser Ile  Arg Cys Ile 
    1295                 1300                 1305             


Lys Lys  Val His His Glu Asn  His Cys Arg Glu Lys  Ile Leu Pro 
    1310                 1315                 1320             


Ser Glu  Asn Leu Tyr Phe Lys  Lys Gln Pro Leu Met  Phe Phe Lys 
    1325                 1330                 1335             


Phe Ser  Glu Pro Ala Ser Leu  Gly Cys Lys Val Ser  Leu Ala Ile 
    1340                 1345                 1350             


Glu Gln  Pro Ile Arg Lys Phe  Ile Leu Asp Ser Ser  Val Leu Val 
    1355                 1360                 1365             


Arg Leu  Lys Asn Arg Thr Thr  Phe Arg Val Ser Glu  Leu Trp Lys 
    1370                 1375                 1380             


Ile Glu  Leu Thr Ile Val Lys  Gln Leu Met Gly Ser  Glu Val Ser 
    1385                 1390                 1395             


Ala Lys  Leu Ala Ala Phe Lys  Thr Leu Leu Phe Asp  Thr Pro Glu 
    1400                 1405                 1410             


Gln Gln  Thr Thr Lys Asn Met  Met Thr Leu Ile Asn  Pro Asp Asp 
    1415                 1420                 1425             


Glu Tyr  Leu Tyr Glu Ile Glu  Ile Glu Tyr Thr Gly  Lys Pro Glu 
    1430                 1435                 1440             


Ser Leu  Thr Ala Ala Asp Val  Ile Lys Ile Lys Asn  Thr Val Leu 
    1445                 1450                 1455             


Thr Leu  Ile Ser Pro Asn His  Leu Met Leu Thr Ala  Tyr His Gln 
    1460                 1465                 1470             


Ala Ile  Glu Phe Ile Ala Ser  His Ile Leu Ser Ser  Glu Ile Leu 
    1475                 1480                 1485             


Leu Ala  Arg Ile Lys Ser Gly  Lys Trp Gly Leu Lys  Arg Leu Leu 
    1490                 1495                 1500             


Pro Gln  Val Lys Ser Met Thr  Lys Ala Asp Tyr Met  Lys Phe Tyr 
    1505                 1510                 1515             


Pro Pro  Val Gly Tyr Tyr Val  Thr Asp Lys Ala Asp  Gly Ile Arg 
    1520                 1525                 1530             


Gly Ile  Ala Val Ile Gln Asp  Thr Gln Ile Tyr Val  Val Ala Asp 
    1535                 1540                 1545             


Gln Leu  Tyr Ser Leu Gly Thr  Thr Gly Ile Glu Pro  Leu Lys Pro 
    1550                 1555                 1560             


Thr Ile  Leu Asp Gly Glu Phe  Met Pro Glu Lys Lys  Glu Phe Tyr 
    1565                 1570                 1575             


Gly Phe  Asp Val Ile Met Tyr  Glu Gly Asn Leu Leu  Thr Gln Gln 
    1580                 1585                 1590             


Gly Phe  Glu Thr Arg Ile Glu  Ser Leu Ser Lys Gly  Ile Lys Val 
    1595                 1600                 1605             


Leu Gln  Ala Phe Asn Ile Lys  Ala Glu Met Lys Pro  Phe Ile Ser 
    1610                 1615                 1620             


Leu Thr  Ser Ala Asp Pro Asn  Val Leu Leu Lys Asn  Phe Glu Ser 
    1625                 1630                 1635             


Ile Phe  Lys Lys Lys Thr Arg  Pro Tyr Ser Ile Asp  Gly Ile Ile 
    1640                 1645                 1650             


Leu Val  Glu Pro Gly Asn Ser  Tyr Leu Asn Thr Asn  Thr Phe Lys 
    1655                 1660                 1665             


Trp Lys  Pro Thr Trp Asp Asn  Thr Leu Asp Phe Leu  Val Arg Lys 
    1670                 1675                 1680             


Cys Pro  Glu Ser Leu Asn Val  Pro Glu Tyr Ala Pro  Lys Lys Gly 
    1685                 1690                 1695             


Phe Ser  Leu His Leu Leu Phe  Val Gly Ile Ser Gly  Glu Leu Phe 
    1700                 1705                 1710             


Lys Lys  Leu Ala Leu Asn Trp  Cys Pro Gly Tyr Thr  Lys Leu Phe 
    1715                 1720                 1725             


Pro Val  Thr Gln Arg Asn Gln  Asn Tyr Phe Pro Val  Gln Phe Gln 
    1730                 1735                 1740             


Pro Ser  Asp Phe Pro Leu Ala  Phe Leu Tyr Tyr His  Pro Asp Thr 
    1745                 1750                 1755             


Ser Ser  Phe Ser Asn Ile Asp  Gly Lys Val Leu Glu  Met Arg Cys 
    1760                 1765                 1770             


Leu Lys  Arg Glu Ile Asn Tyr  Val Arg Trp Glu Ile  Val Lys Ile 
    1775                 1780                 1785             


Arg Glu  Asp Arg Gln Gln Asp  Leu Lys Thr Gly Gly  Tyr Phe Gly 
    1790                 1795                 1800             


Asn Asp  Phe Lys Thr Ala Glu  Leu Thr Trp Leu Asn  Tyr Met Asp 
    1805                 1810                 1815             


Pro Phe  Ser Phe Glu Glu Leu  Ala Lys Gly Pro Ser  Gly Met Tyr 
    1820                 1825                 1830             


Phe Ala  Gly Ala Lys Thr Gly  Ile Tyr Arg Ala Gln  Thr Ala Leu 
    1835                 1840                 1845             


Ile Ser  Phe Ile Lys Gln Glu  Ile Ile Gln Lys Ile  Ser His Gln 
    1850                 1855                 1860             


Ser Trp  Val Ile Asp Leu Gly  Ile Gly Lys Gly Gln  Asp Leu Gly 
    1865                 1870                 1875             


Arg Tyr  Leu Asp Ala Gly Val  Arg His Leu Val Gly  Ile Asp Lys 
    1880                 1885                 1890             


Asp Gln  Thr Ala Leu Ala Glu  Leu Val Tyr Arg Lys  Phe Ser His 
    1895                 1900                 1905             


Ala Thr  Thr Arg Gln His Lys  His Ala Thr Asn Ile  Tyr Val Leu 
    1910                 1915                 1920             


His Gln  Asp Leu Ala Glu Pro  Ala Lys Glu Ile Ser  Glu Lys Val 
    1925                 1930                 1935             


His Gln  Ile Tyr Gly Phe Pro  Lys Glu Gly Ala Ser  Ser Ile Val 
    1940                 1945                 1950             


Ser Asn  Leu Phe Ile His Tyr  Leu Met Lys Asn Thr  Gln Gln Val 
    1955                 1960                 1965             


Glu Asn  Leu Ala Val Leu Cys  His Lys Leu Leu Gln  Pro Gly Gly 
    1970                 1975                 1980             


Met Val  Trp Phe Thr Thr Met  Leu Gly Glu Gln Val  Leu Glu Leu 
    1985                 1990                 1995             


Leu His  Glu Asn Arg Ile Glu  Leu Asn Glu Val Trp  Glu Ala Arg 
    2000                 2005                 2010             


Glu Asn  Glu Val Val Lys Phe  Ala Ile Lys Arg Leu  Phe Lys Glu 
    2015                 2020                 2025             


Asp Ile  Leu Gln Glu Thr Gly  Gln Glu Ile Gly Val  Leu Leu Pro 
    2030                 2035                 2040             


Phe Ser  Asn Gly Asp Phe Tyr  Asn Glu Tyr Leu Val  Asn Thr Ala 
    2045                 2050                 2055             


Phe Leu  Ile Lys Ile Phe Lys  His His Gly Phe Ser  Leu Val Gln 
    2060                 2065                 2070             


Lys Gln  Ser Phe Lys Asp Trp  Ile Pro Glu Phe Gln  Asn Phe Ser 
    2075                 2080                 2085             


Lys Ser  Leu Tyr Lys Ile Leu  Thr Glu Ala Asp Lys  Thr Trp Thr 
    2090                 2095                 2100             


Ser Leu  Phe Gly Phe Ile Cys  Leu Arg Lys Asn Gly  Gly Gly Gly 
    2105                 2110                 2115             


Ser Gly  Gly Gly Gly Ser Gln  Asp Leu His Ala Ile  Gln Leu Gln 
    2120                 2125                 2130             


Leu Glu  Glu Glu Met Phe Asn  Gly Gly Ile Arg Arg  Phe Glu Ala 
    2135                 2140                 2145             


Asp Gln  Gln Arg Gln Ile Ala  Ser Gly Asn Glu Ser  Asp Thr Ala 
    2150                 2155                 2160             


Trp Asn  Arg Arg Leu Leu Ser  Glu Leu Ile Ala Pro  Met Ala Glu 
    2165                 2170                 2175             


Gly Ile  Gln Ala Tyr Lys Glu  Glu Tyr Glu Gly Lys  Arg Gly Arg 
    2180                 2185                 2190             


Ala Pro  Arg Ala Leu Ala Phe  Ile Asn Cys Val Gly  Asn Glu Val 
    2195                 2200                 2205             


Ala Ala  Tyr Ile Thr Met Lys  Ile Val Met Asp Met  Leu Asn Thr 
    2210                 2215                 2220             


Asp Val  Thr Leu Gln Ala Ile  Ala Met Asn Val Ala  Asp Arg Ile 
    2225                 2230                 2235             


Glu Asp  Gln Val Arg Phe Ser  Lys Leu Glu Gly His  Ala Ala Lys 
    2240                 2245                 2250             


Tyr Phe  Glu Lys Val Lys Lys  Ser Leu Lys Ala Ser  Lys Thr Lys 
    2255                 2260                 2265             


Ser Tyr  Arg His Ala His Asn  Val Ala Val Val Ala  Glu Lys Ser 
    2270                 2275                 2280             


Val Ala  Asp Arg Asp Ala Asp  Phe Ser Arg Trp Glu  Ala Trp Pro 
    2285                 2290                 2295             


Lys Asp  Thr Leu Leu Gln Ile  Gly Met Thr Leu Leu  Glu Ile Leu 
    2300                 2305                 2310             


Glu Asn  Ser Val Phe Phe Asn  Gly Gln Pro Val Phe  Leu Arg Thr 
    2315                 2320                 2325             


Leu Arg  Thr Asn Gly Gly Lys  His Gly Val Tyr Tyr  Leu Gln Thr 
    2330                 2335                 2340             


Ser Glu  His Val Gly Glu Trp  Ile Thr Ala Phe Lys  Glu His Val 
    2345                 2350                 2355             


Ala Gln  Leu Ser Pro Ala Tyr  Ala Pro Cys Val Ile  Pro Pro Arg 
    2360                 2365                 2370             


Pro Trp  Val Ser Pro Phe Asn  Gly Gly Phe His Thr  Glu Lys Val 
    2375                 2380                 2385             


Ala Ser  Arg Ile Arg Leu Val  Lys Gly Asn Arg Glu  His Val Arg 
    2390                 2395                 2400             


Lys Leu  Thr Lys Lys Gln Met  Pro Ala Val Tyr Lys  Ala Val Asn 
    2405                 2410                 2415             


Ala Leu  Gln Ala Thr Lys Trp  Gln Val Asn Lys Glu  Val Leu Gln 
    2420                 2425                 2430             


Val Val  Glu Asp Val Ile Arg  Leu Asp Leu Gly Tyr  Gly Val Pro 
    2435                 2440                 2445             


Ser Phe  Lys Pro Leu Ile Asp  Arg Glu Asn Lys Pro  Ala Asn Pro 
    2450                 2455                 2460             


Val Pro  Leu Glu Phe Gln His  Leu Arg Gly Arg Glu  Leu Lys Glu 
    2465                 2470                 2475             


Met Leu  Thr Pro Glu Gln Trp  Gln Ala Phe Ile Asn  Trp Lys Gly 
    2480                 2485                 2490             


Glu Cys  Thr Lys Leu Tyr Thr  Ala Glu Thr Lys Arg  Gly Ser Lys 
    2495                 2500                 2505             


Ser Ala  Ala Thr Val Arg Met  Val Gly Gln Ala Arg  Lys Tyr Ser 
    2510                 2515                 2520             


Gln Phe  Asp Ala Ile Tyr Phe  Val Tyr Ala Leu Asp  Ser Arg Ser 
    2525                 2530                 2535             


Arg Val  Tyr Ala Gln Ser Ser  Thr Leu Ser Pro Gln  Ser Asn Asp 
    2540                 2545                 2550             


Leu Gly  Lys Ala Leu Leu Arg  Phe Thr Glu Gly Gln  Arg Leu Asp 
    2555                 2560                 2565             


Ser Ala  Glu Ala Leu Lys Trp  Phe Leu Val Asn Gly  Ala Asn Asn 
    2570                 2575                 2580             


Trp Gly  Trp Asp Lys Lys Thr  Phe Asp Val Arg Thr  Ala Asn Val 
    2585                 2590                 2595             


Leu Asp  Ser Glu Phe Gln Asp  Met Cys Arg Asp Ile  Ala Ala Asp 
    2600                 2605                 2610             


Pro Leu  Thr Phe Thr Gln Trp  Val Asn Ala Asp Ser  Pro Tyr Gly 
    2615                 2620                 2625             


Phe Leu  Ala Trp Cys Phe Glu  Tyr Ala Arg Tyr Leu  Asp Ala Leu 
    2630                 2635                 2640             


Asp Glu  Gly Thr Gln Asp Gln  Phe Met Thr His Leu  Pro Val His 
    2645                 2650                 2655             


Gln Asp  Gly Ser Cys Ser Gly  Ile Gln His Tyr Ser  Ala Met Leu 
    2660                 2665                 2670             


Ser Asp  Ala Val Gly Ala Lys  Ala Val Asn Leu Lys  Pro Ser Asp 
    2675                 2680                 2685             


Ser Pro  Gln Asp Ile Tyr Gly  Ala Val Ala Gln Val  Val Ile Gln 
    2690                 2695                 2700             


Lys Asn  Tyr Ala Tyr Met Asn  Ala Glu Asp Ala Glu  Thr Phe Thr 
    2705                 2710                 2715             


Ser Gly  Ser Val Thr Leu Thr  Gly Ala Glu Leu Arg  Ser Met Ala 
    2720                 2725                 2730             


Ser Ala  Trp Asp Met Ile Gly  Ile Thr Arg Gly Leu  Thr Lys Lys 
    2735                 2740                 2745             


Pro Val  Met Thr Leu Pro Tyr  Gly Ser Thr Arg Leu  Thr Cys Arg 
    2750                 2755                 2760             


Glu Ser  Val Ile Asp Tyr Ile  Val Asp Leu Glu Glu  Lys Glu Ala 
    2765                 2770                 2775             


Gln Arg  Ala Ile Ala Glu Gly  Arg Thr Ala Asn Pro  Val His Pro 
    2780                 2785                 2790             


Phe Asp  Asn Asp Arg Lys Asp  Ser Leu Thr Pro Ser  Ala Ala Tyr 
    2795                 2800                 2805             


Asn Tyr  Met Thr Ala Leu Ile  Trp Pro Ser Ile Ser  Glu Val Val 
    2810                 2815                 2820             


Lys Ala  Pro Ile Val Ala Met  Lys Met Ile Arg Gln  Leu Ala Arg 
    2825                 2830                 2835             


Phe Ala  Ala Lys Arg Asn Glu  Gly Leu Glu Tyr Pro  Leu Pro Thr 
    2840                 2845                 2850             


Gly Phe  Ile Leu Gln Gln Lys  Ile Met Ala Thr Asp  Met Leu Arg 
    2855                 2860                 2865             


Val Ser  Thr Cys Leu Met Gly  Glu Ile Lys Met Ser  Leu Gln Ile 
    2870                 2875                 2880             


Glu Thr  Asp Val Val Asp Glu  Thr Ala Met Met Gly  Ala Ala Ala 
    2885                 2890                 2895             


Pro Asn  Phe Val His Gly His  Asp Ala Ser His Leu  Ile Leu Thr 
    2900                 2905                 2910             


Val Cys  Asp Leu Val Asp Lys  Gly Ile Thr Ser Val  Ala Val Ile 
    2915                 2920                 2925             


His Asp  Ser Phe Gly Thr His  Ala Gly Arg Thr Ala  Asp Leu Arg 
    2930                 2935                 2940             


Asp Ser  Leu Arg Glu Glu Met  Val Lys Met Tyr Gln  Asn His Asn 
    2945                 2950                 2955             


Ala Leu  Gln Asn Leu Leu Asp  Val His Glu Glu Arg  Trp Leu Val 
    2960                 2965                 2970             


Asp Thr  Gly Ile Gln Val Pro  Glu Gln Gly Glu Phe  Asp Leu Asn 
    2975                 2980                 2985             


Glu Ile  Leu Val Ser Asp Tyr  Cys Phe Ala 
    2990                 2995             


