                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
       Ahn, Green
       Miller, Caitlyn
       Bertozzi, Carolyn R.
       Cochran, Jennifer R.
       Banik, Steven
 
<120>  LYSOSOMAL TARGETING MOLECULES COMPRISING KNOTTIN PEPTIDES AND 
       RELATED COMPOSITIONS AND METHODS

<130>  STAN-1780WO (S20-337)

<150>  US 63/059,010
<151>  2020-07-30

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  PRT
<213>  Ecballium elaterium

<400>  1

Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu 
1               5                   10                  15      


Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
            20                  25              


<210>  2
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys Cys 
1               5                   10                  15      


Asp Pro Ala Ala Thr Cys Tyr Cys Arg Phe Phe Asn Ala Phe Cys Tyr 
            20                  25                  30          


Cys Arg 
        


<210>  3
<211>  29
<212>  PRT
<213>  Unknown

<220>
<223>  Kalata B1 peptide

<400>  3

Cys Gly Glu Thr Cys Val Gly Gly Thr Cys Asn Thr Pro Gly Cys Thr 
1               5                   10                  15      


Cys Ser Trp Pro Val Cys Thr Arg Asn Gly Leu Pro Val 
            20                  25                  


<210>  4
<211>  34
<212>  PRT
<213>  Unknown

<220>
<223>  MCoTI-II peptide

<400>  4

Ser Gly Ser Asp Gly Gly Val Cys Pro Lys Ile Leu Lys Lys Cys Arg 
1               5                   10                  15      


Arg Asp Ser Asp Cys Pro Gly Ala Cys Ile Cys Arg Gly Asn Gly Tyr 
            20                  25                  30          


Cys Gly 
        


<210>  5
<211>  36
<212>  PRT
<213>  Unknown

<220>
<223>  chlorotoxin peptide

<400>  5

Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys 
1               5                   10                  15      


Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Lys Cys Tyr Gly Pro Gln 
            20                  25                  30          


Cys Leu Cys Arg 
        35      


<210>  6
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (15)..(15)
<223>  The amino acid at position 15 is an unnatural amino acid (e.g., 
       5-azido-L-norvaline)

<400>  6

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Xaa Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  7
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Thr Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  8
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (31)..(31)
<223>  The amino acid at position 31 is either Phe or Tyr

<400>  8

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Xaa Cys 
            20                  25                  30          


Gly 
    


<210>  9
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Gly Cys Ala Glu Pro Arg Gly Asp Met Pro Trp Thr Trp Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  10
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Gly Cys Val Gly Gly Arg Gly Asp Trp Ser Pro Lys Trp Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  11
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Gly Cys Ala Glu Leu Arg Gly Asp Arg Ser Tyr Pro Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  12
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Gly Cys Arg Leu Pro Arg Gly Asp Val Pro Arg Pro His Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  13
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Gly Cys Tyr Pro Leu Arg Gly Asp Asn Pro Tyr Ala Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  14
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Gly Cys Thr Ile Gly Arg Gly Asp Trp Ala Pro Ser Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  15
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15

Gly Cys His Pro Pro Arg Gly Asp Asn Pro Pro Val Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  16
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16

Gly Cys Pro Glu Pro Arg Gly Asp Asn Pro Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  17
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Gly Cys Leu Pro Pro Arg Gly Asp Asn Pro Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  18
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18

Gly Cys His Leu Gly Arg Gly Asp Trp Ala Pro Val Gly Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  19
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19

Gly Cys Asn Val Gly Arg Gly Asp Trp Ala Pro Ser Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  20
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20

Gly Cys Phe Pro Gly Arg Gly Asp Trp Ala Pro Ser Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  21
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21

Gly Cys Pro Leu Pro Arg Gly Asp Asn Pro Pro Thr Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  22
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  22

Gly Cys Ser Glu Ala Arg Gly Asp Asn Pro Arg Leu Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  23
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  23

Gly Cys Leu Leu Gly Arg Gly Asp Trp Ala Pro Glu Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  24
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24

Gly Cys His Val Gly Arg Gly Asp Trp Ala Pro Leu Lys Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  25
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25

Gly Cys Val Arg Gly Arg Gly Asp Trp Ala Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  26
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26

Gly Cys Leu Gly Gly Arg Gly Asp Trp Ala Pro Pro Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  27
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  27

Gly Cys Phe Val Gly Arg Gly Asp Trp Ala Pro Leu Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  28
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28

Gly Cys Pro Val Gly Arg Gly Asp Trp Ser Pro Ala Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  29
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  30
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30

Gly Cys Tyr Gln Gly Arg Gly Asp Trp Ser Pro Ser Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  31
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31

Gly Cys Ala Pro Gly Arg Gly Asp Trp Ala Pro Ser Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  32
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32

Gly Cys Val Gln Gly Arg Gly Asp Trp Ser Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  33
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33

Gly Cys His Val Gly Arg Gly Asp Trp Ala Pro Glu Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  34
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34

Gly Cys Asp Gly Gly Arg Gly Asp Trp Ala Pro Pro Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  35
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  35

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Glu Trp Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  36
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36

Gly Cys Pro Arg Gly Arg Gly Asp Trp Ser Pro Pro Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  37
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  37

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Ser Gly Arg Gly Asp Asn Asp 
            20                  25                  30          


Leu Val Cys Tyr Cys Arg 
        35              


<210>  38
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  38

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Lys Gly Arg Gly Asp Ala Arg 
            20                  25                  30          


Leu Gln Cys Tyr Cys Arg 
        35              


<210>  39
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  39

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Gly Arg Gly Asp Asp Asn 
            20                  25                  30          


Leu Lys Cys Tyr Cys Arg 
        35              


<210>  40
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  40

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Gly Arg Gly Asp Arg Asp 
            20                  25                  30          


Met Lys Cys Tyr Cys Arg 
        35              


<210>  41
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  41

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Tyr Gly Arg Gly Asp Asn Asp 
            20                  25                  30          


Leu Arg Cys Tyr Cys Arg 
        35              


<210>  42
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (15)..(15)
<223>  The amino acid at position 15 is 5-azido-L-norvaline

<400>  42

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Xaa Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Tyr Cys 
            20                  25                  30          


Gly 
    


