                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  CANINE AND FELINE INDUCIBLE EXPRESSION CONSTRUCTS FOR GENE 
       THERAPY APPLICATIONS

<130>  UPN-20-9294.PCT

<150>  US 63/056,985
<151>  2020-07-27

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  279
<212>  DNA
<213>  Canis familiaris

<400>  1
atcctctggc atgagatgtg gcatgaaggc ctggaagagg catctcgttt gtactttggg       60

gaaaggaacg tgaaaggcat gtttgaggtg ctggagccct tgcatgctat gatggaacgg      120

ggcccccaga ctctgaagga aacatccttt aatcaggcct atggtcgaga tttaatggag      180

gcccaagagt ggtgcaggaa gtacatgaaa tcagggaacg tcaaggacct cacccaagcc      240

tgggacctct attatcacgt gttccgacga atctcaaag                             279


<210>  2
<211>  279
<212>  DNA
<213>  Felis catus

<400>  2
atggactatc ctgctgccaa gagggtcaag ttggactcta gaatcctctg gcatgagatg       60

tggcatgaag gcctggaaga ggcatctcgt ttgtactttg gggaaaggaa cgtgaaaggc      120

atgtttgagg tgctggagcc cttgcatgct atgatggaac ggggccccca gactctgaag      180

gaaacatcct ttaatcaggc ctatggtcga gatttaatgg aggcccaaga gtggtgcagg      240

aagtacatga aatcagggaa cgtcaaggac ctcacccaa                             279


<210>  3
<211>  279
<212>  DNA
<213>  Homo sapiens

<400>  3
atggactatc ctgctgccaa gagggtcaag ttggactcta gaatcctctg gcatgagatg       60

tggcatgaag gcctggaaga ggcatctcgt ttgtactttg gggaaaggaa cgtgaaaggc      120

atgtttgagg tgctggagcc cttgcatgct atgatggaac ggggccccca gactctgaag      180

gaaacatcct ttaatcaggc ctatggtcga gatttaatgg aggcccaaga gtggtgcagg      240

aagtacatga aatcagggaa tgtcaaggac ctcctccaa                             279


<210>  4
<211>  546
<212>  DNA
<213>  Canis familiaris

<400>  4
gaggaattca gccccatggt gttctctagc ggccagatca gctctcagac aagcgccctt       60

gcttctgccc ctgctcctgc tccaattctg gctccagctc ctcctgcacc agctccagca      120

cctattctgg cacctggact ggctcaggct atggctccac cagcaccaaa gacaacacag      180

gccggcgagg gaacactgac agaagctctg ctgcagctcc agttcgacgc cgacgaggat      240

ctgggagccc tgctgggcaa ttctgctgat cctgccgtgt tcaccgatct ggccagcgtg      300

gacaatagcg agttccagca gctcctgaac cagggcgtta gtgtggcccc tcatacagcc      360

gagcctatgc tgatggaata ccccgaggct atcaccagac tggtcaccgg ctctcaaaga      420

cctccagatc ctgtgcctgc tccagtggga gcatctgggc tccccaatgg cctcctttca      480

ggagatgaag acttctcctc cattgcggac atggacttct cagccctgct gagtcagatc      540

agctcc                                                                 546


<210>  5
<211>  495
<212>  DNA
<213>  Felis catus

<400>  5
gaggaattca gccccatggt gttccccagc ggacagatcc catctcagac accagctctg       60

gctccagctc ctgctcctat tcttgctcct gcaccagcct ctgtgcctgc tccagcacct      120

gttccggcac cagcaccagc tccggctccg gctccagcac caatacttgc tccaggactg      180

gctcaggctg tggtgccgcc agctcctaaa acaacacaag ccggcgaggg cacactgaca      240

gaagctctgc tgcatctgca gttcgacgcc gacgaggatc tgggagccct gctgggcaat      300

tctgctgatc ctgccgtgtt caccgatctg gccagcgtgg acaatagcga gttccagcag      360

ctcctgaacc agggcgttag tgtggctcct catcctgccg agcctatgct gatggaatac      420

cccgaggcta tcaccagact ggtcaccggc tctcaaagac ctccagatcc agcaccggca      480

ccactgggag catct                                                       495


<210>  6
<211>  573
<212>  DNA
<213>  Homo sapiens

<400>  6
gatgagtttc ccaccatggt gtttccttct gggcagatca gccaggcctc ggccttggcc       60

ccggcccctc cccaagtcct gccccaggct ccagcccctg cccctgctcc agccatggta      120

tcagctctgg cccaggcccc agcccctgtc ccagtcctag ccccaggccc tcctcaggct      180

gtggccccac ctgcccccaa gcccacccag gctggggaag gaacgctgtc agaggccctg      240

ctgcagctgc agtttgatga tgaagacctg ggggccttgc ttggcaacag cacagaccca      300

gctgtgttca cagacctggc atccgtcgac aactccgagt ttcagcagct gctgaaccag      360

ggcatacctg tggcccccca cacaactgag cccatgctga tggagtaccc tgaggctata      420

actcgcctag tgacaggggc ccagaggccc cccgacccag ctcctgctcc actgggggcc      480

ccggggctcc ccaatggcct cctttcagga gatgaagact tctcctccat tgcggacatg      540

gacttctcag ccctgctgag tcagatcagc tcc                                   573


<210>  7
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  7
ggagtgcagg tggaaaccat ctccccagga gacgggcgca ccttccccaa gcgcggccag       60

acctgcgtgg tgcactacac cgggatgctt gaagatggaa agaaatttga ttcctcccgg      120

gacagaaaca agccctttaa gtttatgcta ggcaagcagg aggtgatccg aggctgggaa      180

gaaggggttg cccagatgag tgtgggtcag agagccaaac tgactatatc tccagattat      240

gcctatggtg ccactgggca cccaggcatc atcccaccaa acgccactct cgtcttcgat      300

gtggagcttc taaaactgga a                                                321


<210>  8
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  8
ggcgttcagg tggaaaccat cagtccaggg gatggccgaa cttttccaaa gagagggcag       60

acttgcgtcg tgcattatac tggtatgctg gaggatggga aaaagttcga ctcttccaga      120

gatcggaaca aaccattcaa attcatgctc gggaaacagg aagttatccg cggatgggag      180

gagggcgtgg cccagatgtc cgtgggccag cgcgccaagc taaccatctc cccagactac      240

gcctacggag ccaccggaca ccccggtatc atacccccaa acgccaccct tgtgtttgac      300

gtggaactgc ttaagctaga g                                                321


<210>  9
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  9
ggcgtgcagg tcgagaccat cagccccggc gacggccgca cctttcccaa gagaggccag       60

acttgcgtgg tccactacac cggcatgctg gaggacggca agaagttcga cagcagccgc      120

gaccgcaaca agcccttcaa gttcatgctg ggcaaacagg aagtgatccg cggctgggag      180

gaaggcgtgg ctcagatgag cgtggggcag cgggccaagc tgaccatcag ccccgactat      240

gcctacggcg ccaccggcca ccccggcatc atccccccca acgccaccct cgtgttcgac      300

gtggagctgc tgaagctgga gtga                                             324


<210>  10
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  10
ggagtgcagg tggaaaccat ctccccagga gacgggcgca ccttccccaa gcgcggccag       60

acctgcgtgg tgcactacac cgggatgctt gaagatggaa agaaatttga ttcctcccgg      120

gacagaaaca agccctttaa gtttatgcta ggcaagcagg aggtgatccg aggctgggaa      180

gaaggggttg cccagatgag tgtgggtcag agagccaaac tgactatatc tccagattat      240

gcctatggtg ccactgggca cccaggcatc atcccaccaa acgccactct cgtcttcgat      300

gtggagcttc taaaactgga aactagaggc gttcaggtgg aaaccatcag tccaggggat      360

ggccgaactt ttccaaagag agggcagact tgcgtcgtgc attatactgg tatgctggag      420

gatgggaaaa agttcgactc ttccagagat cggaacaaac cattcaaatt catgctcggg      480

aaacaggaag ttatccgcgg atgggaggag ggcgtggccc agatgtccgt gggccagcgc      540

gccaagctaa ccatctcccc agactacgcc tacggagcca ccggacaccc cggtatcata      600

cccccaaacg ccacccttgt gtttgacgtg gaactgctta agctagagac tagaggcgtg      660

caggtcgaga ccatcagccc cggcgacggc cgcacctttc ccaagagagg ccagacttgc      720

gtggtccact acaccggcat gctggaggac ggcaagaagt tcgacagcag ccgcgaccgc      780

aacaagccct tcaagttcat gctgggcaaa caggaagtga tccgcggctg ggaggaaggc      840

gtggctcaga tgagcgtggg gcagcgggcc aagctgacca tcagccccga ctatgcctac      900

ggcgccaccg gccaccccgg catcatcccc cccaacgcca ccctcgtgtt cgacgtggag      960

ctgctgaagc tggagtga                                                    978


<210>  11
<211>  121
<212>  DNA
<213>  Homo sapiens

<400>  11
aacattttga cacccccata atatttttcc agaattaaca gtataaattg catctcttgt       60

tcaagagttc cctatcactc tctttaatca ctactcacag taacctcaac tcctgccaca      120

a                                                                      121


<210>  12
<211>  107
<212>  DNA
<213>  Homo sapiens

<400>  12
aacattttga cacccccata atatttttcc agaattaaca gtataaattg catctcttgt       60

tcaagagttc cctatcactc tctttaatca ctactcacag taacctc                    107


<210>  13
<211>  639
<212>  DNA
<213>  Human cytomegalovirus

<400>  13
acgcgttcga gctcgccccg ttacataact tacggtaaat ggcccgcctg gctgaccgcc       60

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      120

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      180

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      240

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      300

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      360

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      420

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      480

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      540

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgggaccg      600

atccagcctc cgggggatct tggtggcgtg aaactcccg                             639


<210>  14
<211>  4949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence


<220>
<221>  CDS
<222>  (856)..(1134)
<223>  FRE

<220>
<221>  CDS
<222>  (1183)..(1677)
<223>  P65 feline

<220>
<221>  CDS
<222>  (2281)..(2316)
<223>  Myc NLS

<220>
<221>  CDS
<222>  (2317)..(2685)
<223>  ZFHD

<220>
<221>  CDS
<222>  (2692)..(3012)
<223>  FKBP

<220>
<221>  CDS
<222>  (3019)..(3339)
<223>  FKBPw1

<220>
<221>  CDS
<222>  (3346)..(3669)
<223>  FKBPw2

<220>
<221>  misc_feature
<222>  (3802)..(3946)

<400>  14
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

agtacgcgtt cgagctcgcc ccgttacata acttacggta aatggcccgc ctggctgacc      240

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat      300

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      360

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc      420

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta      480

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg      540

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt      600

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac      660

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa      720

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga      780

ccgatccagc ctccggggga tcttggtggc gtgaaactcc cgcagatctt cggccagcga      840

attccagaag ccacc atg gac tat cct gct gcc aag agg gtc aag ttg gac       891
                 Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp          
                 1               5                   10                   

tct aga atc ctc tgg cat gag atg tgg cat gaa ggc ctg gaa gag gca        939
Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala           
        15                  20                  25                        

tct cgt ttg tac ttt ggg gaa agg aac gtg aaa ggc atg ttt gag gtg        987
Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val           
    30                  35                  40                            

ctg gag ccc ttg cat gct atg atg gaa cgg ggc ccc cag act ctg aag       1035
Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys           
45                  50                  55                  60            

gaa aca tcc ttt aat cag gcc tat ggt cga gat tta atg gag gcc caa       1083
Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln           
                65                  70                  75                

gag tgg tgc agg aag tac atg aaa tca ggg aac gtc aag gac ctc acc       1131
Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr           
            80                  85                  90                    

caa gcctgggacc tctattatca cgtgttccga cgaatctcaa agactaga gag gaa      1188
Gln                                                      Glu Glu          
                                                             95           

ttc agc ccc atg gtg ttc ccc agc gga cag atc cca tct cag aca cca       1236
Phe Ser Pro Met Val Phe Pro Ser Gly Gln Ile Pro Ser Gln Thr Pro           
                100                 105                 110               

gct ctg gct cca gct cct gct cct att ctt gct cct gca cca gcc tct       1284
Ala Leu Ala Pro Ala Pro Ala Pro Ile Leu Ala Pro Ala Pro Ala Ser           
            115                 120                 125                   

gtg cct gct cca gca cct gtt ccg gca cca gca cca gct ccg gct ccg       1332
Val Pro Ala Pro Ala Pro Val Pro Ala Pro Ala Pro Ala Pro Ala Pro           
        130                 135                 140                       

gct cca gca cca ata ctt gct cca gga ctg gct cag gct gtg gtg ccg       1380
Ala Pro Ala Pro Ile Leu Ala Pro Gly Leu Ala Gln Ala Val Val Pro           
    145                 150                 155                           

cca gct cct aaa aca aca caa gcc ggc gag ggc aca ctg aca gaa gct       1428
Pro Ala Pro Lys Thr Thr Gln Ala Gly Glu Gly Thr Leu Thr Glu Ala           
160                 165                 170                 175           

ctg ctg cat ctg cag ttc gac gcc gac gag gat ctg gga gcc ctg ctg       1476
Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp Leu Gly Ala Leu Leu           
                180                 185                 190               

ggc aat tct gct gat cct gcc gtg ttc acc gat ctg gcc agc gtg gac       1524
Gly Asn Ser Ala Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp           
            195                 200                 205                   

aat agc gag ttc cag cag ctc ctg aac cag ggc gtt agt gtg gct cct       1572
Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Val Ser Val Ala Pro           
        210                 215                 220                       

cat cct gcc gag cct atg ctg atg gaa tac ccc gag gct atc acc aga       1620
His Pro Ala Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg           
    225                 230                 235                           

ctg gtc acc ggc tct caa aga cct cca gat cca gca ccg gca cca ctg       1668
Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu           
240                 245                 250                 255           

gga gca tct gggctcccca atggcctcct ttcaggagat gaagacttct               1717
Gly Ala Ser                                                               
                                                                          

cctccattgc ggacatggac ttctcagccc tgctgagtca gatcagctcc tgataattcc     1777

ggttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg     1837

tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt     1897

tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag     1957

cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc     2017

cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga     2077

tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg     2137

cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat     2197

gtgtttagtc gaggttaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct     2257

ttgaaaaaca cgatgataat acc atg gac tat cct gct gcc aag agg gtc aag     2310
                          Met Asp Tyr Pro Ala Ala Lys Arg Val Lys         
                              260                 265                     

ttg gac tct aga gaa cgc cca tat gct tgc cct gtc gag tcc tgc gat       2358
Leu Asp Ser Arg Glu Arg Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp           
    270                 275                 280                           

cgc cgc ttt tct cgc tcg gat gag ctt acc cgc cat atc cgc atc cac       2406
Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His           
285                 290                 295                 300           

aca ggc cag aag ccc ttc cag tgt cga atc tgc atg cgt aac ttc agt       2454
Thr Gly Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser           
                305                 310                 315               

cgt agt gac cac ctt acc acc cac atc cgc acc cac aca ggc ggc ggc       2502
Arg Ser Asp His Leu Thr Thr His Ile Arg Thr His Thr Gly Gly Gly           
            320                 325                 330                   

cgc agg agg aag aaa cgc acc agc ata gag acc aac atc cgt gtg gcc       2550
Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala           
        335                 340                 345                       

tta gag aag agt ttc ttg gag aat caa aag cct acc tcg gaa gag atc       2598
Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile           
    350                 355                 360                           

act atg att gct gat cag ctc tcc atg gaa aaa gag gtg att cgt gtt       2646
Thr Met Ile Ala Asp Gln Leu Ser Met Glu Lys Glu Val Ile Arg Val           
365                 370                 375                 380           

tgg ttc tgt aac cgc cgc cag aaa gaa aaa aga atc aac actaga gga        2694
Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn        Gly            
                385                 390                                   

gtg cag gtg gaa acc atc tcc cca gga gac ggg cgc acc ttc ccc aag       2742
Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys           
395                 400                 405                 410           

cgc ggc cag acc tgc gtg gtg cac tac acc ggg atg ctt gaa gat gga       2790
Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly           
                415                 420                 425               

aag aaa ttt gat tcc tcc cgg gac aga aac aag ccc ttt aag ttt atg       2838
Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met           
            430                 435                 440                   

cta ggc aag cag gag gtg atc cga ggc tgg gaa gaa ggg gtt gcc cag       2886
Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln           
        445                 450                 455                       

atg agt gtg ggt cag aga gcc aaa ctg act ata tct cca gat tat gcc       2934
Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala           
    460                 465                 470                           

tat ggt gcc act ggg cac cca ggc atc atc cca cca aac gcc act ctc       2982
Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr Leu           
475                 480                 485                 490           

gtc ttc gat gtg gag ctt cta aaa ctg gaa actaga ggc gtt cag gtg        3030
Val Phe Asp Val Glu Leu Leu Lys Leu Glu        Gly Val Gln Val            
                495                 500                                   

gaa acc atc agt cca ggg gat ggc cga act ttt cca aag aga ggg cag       3078
Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln           
505                 510                 515                 520           

act tgc gtc gtg cat tat act ggt atg ctg gag gat ggg aaa aag ttc       3126
Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe           
                525                 530                 535               

gac tct tcc aga gat cgg aac aaa cca ttc aaa ttc atg ctc ggg aaa       3174
Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys           
            540                 545                 550                   

cag gaa gtt atc cgc gga tgg gag gag ggc gtg gcc cag atg tcc gtg       3222
Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val           
        555                 560                 565                       

ggc cag cgc gcc aag cta acc atc tcc cca gac tac gcc tac gga gcc       3270
Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala           
    570                 575                 580                           

acc gga cac ccc ggt atc ata ccc cca aac gcc acc ctt gtg ttt gac       3318
Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr Leu Val Phe Asp           
585                 590                 595                 600           

gtg gaa ctg ctt aag cta gag actaga ggc gtg cag gtc gag acc atc        3366
Val Glu Leu Leu Lys Leu Glu        Gly Val Gln Val Glu Thr Ile            
                605                        610                            

agc ccc ggc gac ggc cgc acc ttt ccc aag aga ggc cag act tgc gtg       3414
Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val           
615                 620                 625                 630           

gtc cac tac acc ggc atg ctg gag gac ggc aag aag ttc gac agc agc       3462
Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser           
                635                 640                 645               

cgc gac cgc aac aag ccc ttc aag ttc atg ctg ggc aaa cag gaa gtg       3510
Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val           
            650                 655                 660                   

atc cgc ggc tgg gag gaa ggc gtg gct cag atg agc gtg ggg cag cgg       3558
Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg           
        665                 670                 675                       

gcc aag ctg acc atc agc ccc gac tat gcc tac ggc gcc acc ggc cac       3606
Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His           
    680                 685                 690                           

ccc ggc atc atc ccc ccc aac gcc acc ctc gtg ttc gac gtg gag ctg       3654
Pro Gly Ile Ile Pro Pro Asn Ala Thr Leu Val Phe Asp Val Glu Leu           
695                 700                 705                 710           

ctg aag ctg gag tga taaggatccc cactccagtg cccaccagcc ttgtcctaat       3709
Leu Lys Leu Glu                                                           
                                                                          

aaaattaagt tgcatcattt tgtctgacta ggtgtccttc tataatatta tggggtggag     3769

gggggtggtt tggagcaagg cgcgtgctag ctaatgatgg gcgctcgagt aatgatgggc     3829

ggtcgactaa tgatgggcgc tcgagtaatg atgggcgtct agctaatgat gggcgctcga     3889

gtaatgatgg gcggtcgact aatgatgggc gctcgagtaa tgatgggcgt ctagaacgcg     3949

aattaattca acattttgac acccccataa tatttttcca gaattaacag tataaattgc     4009

atctcttgtt caagagttcc ctatcactct ctttaatcac tactcacagt aacctcaact     4069

cctgccacaa gcttgccctg cagcgggaat tccaccatgg gggtgcacga atgtcctgcc     4129

tggctgtggc ttctcctgtc tctgctctcg ctccctctgg gcctcccagt cccgggcgcc     4189

ccaccacgcc tcatctgtga cagccgagtc ctggagaggt acctcttgga ggccaaggag     4249

gccgagaatg tcacgatggg ctgttccgaa agctgcagct tgaatgagaa tatcaccgtc     4309

ccagacacca aagttaactt ctatgcctgg aagaggatgg aggtcgggca gcaggctgta     4369

gaagtctggc agggcctggc cctgctctca gaagctgtcc tgcggggcca ggccgtgttg     4429

gccaactctt cccagccttt cgagcccctg cagctgcaca tggataaagc catcagtggc     4489

cttcgcagca tcaccactct gcttcgggcg ctgggagccc aggaagccat ctccctccca     4549

gatgcggcct cggctgctcc actccgaacc atcactgctg acactttctg caaactcttc     4609

cgagtctact ccaatttcct ccggggaaag ctgaagctgt acacggggga ggcctgcagg     4669

agaggggaca gatgaccatc gattacgcct aataaagagc tcagatgcat gcatcagagt     4729

gtgttggttt tttgtgtgtg gcgcgccgat cctcgagact agagcatggc tacgtagata     4789

agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc     4849

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4909

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcca                           4949


<210>  15
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Ile Leu 
1               5                   10                  15      


Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr 
            20                  25                  30          


Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu 
        35                  40                  45              


His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe 
    50                  55                  60                  


Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg 
65                  70                  75                  80  


Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln 
                85                  90              


<210>  16
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Glu Glu Phe Ser Pro Met Val Phe Pro Ser Gly Gln Ile Pro Ser Gln 
1               5                   10                  15      


Thr Pro Ala Leu Ala Pro Ala Pro Ala Pro Ile Leu Ala Pro Ala Pro 
            20                  25                  30          


Ala Ser Val Pro Ala Pro Ala Pro Val Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Ala Pro Ile Leu Ala Pro Gly Leu Ala Gln Ala Val 
    50                  55                  60                  


Val Pro Pro Ala Pro Lys Thr Thr Gln Ala Gly Glu Gly Thr Leu Thr 
65                  70                  75                  80  


Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp Leu Gly Ala 
                85                  90                  95      


Leu Leu Gly Asn Ser Ala Asp Pro Ala Val Phe Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Val Ser Val 
        115                 120                 125             


Ala Pro His Pro Ala Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile 
    130                 135                 140                 


Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro Ala Pro Ala 
145                 150                 155                 160 


Pro Leu Gly Ala Ser 
                165 


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10          


<210>  18
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Ser Arg Glu Arg Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg 
1               5                   10                  15      


Phe Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly 
            20                  25                  30          


Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser 
        35                  40                  45              


Asp His Leu Thr Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg 
    50                  55                  60                  


Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu 
65                  70                  75                  80  


Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met 
                85                  90                  95      


Ile Ala Asp Gln Leu Ser Met Glu Lys Glu Val Ile Arg Val Trp Phe 
            100                 105                 110         


Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn 
        115                 120             


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  22
<211>  4910
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence


<220>
<221>  CDS
<222>  (859)..(897)
<223>  Myc NLS

<220>
<221>  CDS
<222>  (898)..(1176)
<223>  FRB

<220>
<221>  CDS
<222>  (1183)..(1728)
<223>  canine P65 TA

<220>
<221>  CDS
<222>  (2242)..(2646)
<223>  ZHFD

<220>
<221>  CDS
<222>  (2653)..(2973)
<223>  FKBP

<220>
<221>  CDS
<222>  (2980)..(3300)
<223>  FKBPw1

<220>
<221>  CDS
<222>  (3307)..(3630)
<223>  FKBPw2

<220>
<221>  misc_feature
<222>  (3307)..(3630)

<400>  22
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

agtacgcgtt cgagctcgcc ccgttacata acttacggta aatggcccgc ctggctgacc      240

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat      300

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      360

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc      420

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta      480

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg      540

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt      600

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac      660

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa      720

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga      780

ccgatccagc ctccggggga tcttggtggc gtgaaactcc cgcagatctt cggccagcga      840

attccagaag ccaccatg gac tat cct gct gcc aag agg gcc aga ttg gac        891
                    Asp Tyr Pro Ala Ala Lys Arg Ala Arg Leu Asp           
                    1               5                   10                

tct aga atc ctc tgg cat gag atg tgg cat gaa ggc ctg gaa gag gca        939
Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala           
            15                  20                  25                    

tct cgt ttg tac ttt ggg gaa agg aac gtg aaa ggc atg ttt gag gtg        987
Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val           
        30                  35                  40                        

ctg gag ccc ttg cat gct atg atg gaa cgg ggc ccc cag act ctg aag       1035
Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys           
    45                  50                  55                            

gaa aca tcc ttt aat cag gcc tat ggt cga gat tta atg gag gcc caa       1083
Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln           
60                  65                  70                  75            

gag tgg tgc agg aag tac atg aaa tca ggg aac gtc aag gac ctc acc       1131
Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr           
                80                  85                  90                

caa gcc tgg gac ctc tat tat cac gtg ttc cga cga atc tca aag           1176
Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys               
            95                  100                 105                   

actaga gag gaa ttc agc ccc atg gtg ttc tct agc ggc cag atc agc        1224
       Glu Glu Phe Ser Pro Met Val Phe Ser Ser Gly Gln Ile Ser            
                   110                 115                 120            

tct cag aca agc gcc ctt gct tct gcc cct gct cct gct cca att ctg       1272
Ser Gln Thr Ser Ala Leu Ala Ser Ala Pro Ala Pro Ala Pro Ile Leu           
                125                 130                 135               

gct cca gct cct cct gca cca gct cca gca cct att ctg gca cct gga       1320
Ala Pro Ala Pro Pro Ala Pro Ala Pro Ala Pro Ile Leu Ala Pro Gly           
            140                 145                 150                   

ctg gct cag gct atg gct cca cca gca cca aag aca aca cag gcc ggc       1368
Leu Ala Gln Ala Met Ala Pro Pro Ala Pro Lys Thr Thr Gln Ala Gly           
        155                 160                 165                       

gag gga aca ctg aca gaa gct ctg ctg cag ctc cag ttc gac gcc gac       1416
Glu Gly Thr Leu Thr Glu Ala Leu Leu Gln Leu Gln Phe Asp Ala Asp           
    170                 175                 180                           

gag gat ctg gga gcc ctg ctg ggc aat tct gct gat cct gcc gtg ttc       1464
Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Ala Asp Pro Ala Val Phe           
185                 190                 195                 200           

acc gat ctg gcc agc gtg gac aat agc gag ttc cag cag ctc ctg aac       1512
Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn           
                205                 210                 215               

cag ggc gtt agt gtg gcc cct cat aca gcc gag cct atg ctg atg gaa       1560
Gln Gly Val Ser Val Ala Pro His Thr Ala Glu Pro Met Leu Met Glu           
            220                 225                 230                   

tac ccc gag gct atc acc aga ctg gtc acc ggc tct caa aga cct cca       1608
Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro           
        235                 240                 245                       

gat cct gtg cct gct cca gtg gga gca tct ggg ctc ccc aat ggc ctc       1656
Asp Pro Val Pro Ala Pro Val Gly Ala Ser Gly Leu Pro Asn Gly Leu           
    250                 255                 260                           

ctt tca gga gat gaa gac ttc tcc tcc att gcg gac atg gac ttc tca       1704
Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser           
265                 270                 275                 280           

gcc ctg ctg agt cag atc agc tcc tgataattcc ggttattttc caccatattg      1758
Ala Leu Leu Ser Gln Ile Ser Ser                                           
                285                                                       

ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct     1818

aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca     1878

gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg     1938

aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct     1998

gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa     2058

tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt     2118

atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa     2178

aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat     2238

acc atg gac tat cct gct gcc aag agg gcc aga ttg gac tct aga gaa       2286
    Met Asp Tyr Pro Ala Ala Lys Arg Ala Arg Leu Asp Ser Arg Glu           
        290                 295                 300                       

cgc cca tat gct tgc cct gtc gag tcc tgc gat cgc cgc ttt tct cgc       2334
Arg Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg           
    305                 310                 315                           

tcg gat gag ctt acc cgc cat atc cgc atc cac aca ggc cag aag ccc       2382
Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro           
320                 325                 330                 335           

ttc cag tgt cga atc tgc atg cgt aac ttc agt cgt agt gac cac ctt       2430
Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu           
                340                 345                 350               

acc acc cac atc cgc acc cac aca ggc ggc ggc cgc agg agg aag aaa       2478
Thr Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys           
            355                 360                 365                   

cgc acc agc ata gag acc aac atc cgt gtg gcc tta gag aag agt ttc       2526
Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe           
        370                 375                 380                       

ttg gag aat caa aag cct acc tcg gaa gag atc act atg att gct gat       2574
Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp           
    385                 390                 395                           

cag ctc tcc atg gaa aaa gag gtg att cgt gtt tgg ttc tgt aac cgc       2622
Gln Leu Ser Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg           
400                 405                 410                 415           

cgc cag aaa gaa aaa aga atc aac actaga gga gtg cag gtg gaa acc        2670
Arg Gln Lys Glu Lys Arg Ile Asn        Gly Val Gln Val Glu Thr            
                420                        425                            

atc tcc cca gga gac ggg cgc acc ttc ccc aag cgc ggc cag acc tgc       2718
Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys           
430                 435                 440                 445           

gtg gtg cac tac acc ggg atg ctt gaa gat gga aag aaa ttt gat tcc       2766
Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser           
                450                 455                 460               

tcc cgg gac aga aac aag ccc ttt aag ttt atg cta ggc aag cag gag       2814
Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu           
            465                 470                 475                   

gtg atc cga ggc tgg gaa gaa ggg gtt gcc cag atg agt gtg ggt cag       2862
Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln           
        480                 485                 490                       

aga gcc aaa ctg act ata tct cca gat tat gcc tat ggt gcc act ggg       2910
Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly           
    495                 500                 505                           

cac cca ggc atc atc cca cca aac gcc act ctc gtc ttc gat gtg gag       2958
His Pro Gly Ile Ile Pro Pro Asn Ala Thr Leu Val Phe Asp Val Glu           
510                 515                 520                 525           

ctt cta aaa ctg gaa actaga ggc gtt cag gtg gaa acc atc agt cca        3006
Leu Leu Lys Leu Glu        Gly Val Gln Val Glu Thr Ile Ser Pro            
                530                        535                            

ggg gat ggc cga act ttt cca aag aga ggg cag act tgc gtc gtg cat       3054
Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His           
540                 545                 550                 555           

tat act ggt atg ctg gag gat ggg aaa aag ttc gac tct tcc aga gat       3102
Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp           
                560                 565                 570               

cgg aac aaa cca ttc aaa ttc atg ctc ggg aaa cag gaa gtt atc cgc       3150
Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg           
            575                 580                 585                   

gga tgg gag gag ggc gtg gcc cag atg tcc gtg ggc cag cgc gcc aag       3198
Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys           
        590                 595                 600                       

cta acc atc tcc cca gac tac gcc tac gga gcc acc gga cac ccc ggt       3246
Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly           
    605                 610                 615                           

atc ata ccc cca aac gcc acc ctt gtg ttt gac gtg gaa ctg ctt aag       3294
Ile Ile Pro Pro Asn Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys           
620                 625                 630                 635           

cta gag actaga ggc gtg cag gtc gag acc atc agc ccc ggc gac ggc        3342
Leu Glu        Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly            
                       640                 645                            

cgc acc ttt ccc aag aga ggc cag act tgc gtg gtc cac tac acc ggc       3390
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly           
650                 655                 660                 665           

atg ctg gag gac ggc aag aag ttc gac agc agc cgc gac cgc aac aag       3438
Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys           
                670                 675                 680               

ccc ttc aag ttc atg ctg ggc aaa cag gaa gtg atc cgc ggc tgg gag       3486
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu           
            685                 690                 695                   

gaa ggc gtg gct cag atg agc gtg ggg cag cgg gcc aag ctg acc atc       3534
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile           
        700                 705                 710                       

agc ccc gac tat gcc tac ggc gcc acc ggc cac ccc ggc atc atc ccc       3582
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro           
    715                 720                 725                           

ccc aac gcc acc ctc gtg ttc gac gtg gag ctg ctg aag ctg gag tga       3630
Pro Asn Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu               
730                 735                 740                               

taaggatccc cactccagtg cccaccagcc ttgtcctaat aaaattaagt tgcatcattt     3690

tgtctgacta ggtgtccttc tataatatta tggggtggag gggggtggtt tggagcaagg     3750

cgcgtgctag ctaatgatgg gcgctcgagt aatgatgggc ggtcgactaa tgatgggcgc     3810

tcgagtaatg atgggcgtct agctaatgat gggcgctcga gtaatgatgg gcggtcgact     3870

aatgatgggc gctcgagtaa tgatgggcgt ctagaacgcg aattaattca acattttgac     3930

acccccataa tatttttcca gaattaacag tataaattgc atctcttgtt caagagttcc     3990

ctatcactct ctttaatcac tactcacagt aacctcaact cctgccacaa gcttgccctg     4050

cagcgggaat tccaccatgg gggtgcacga atgtcctgcc tggctgtggc ttctcctgtc     4110

tctgctctcg ctccctctgg gcctcccagt cccgggcgcc ccaccacgcc tcatctgtga     4170

cagccgagtc ctggagaggt acctcttgga ggccaaggag gccgagaatg tcacgatggg     4230

ctgttccgaa agctgcagct tgaatgagaa tatcaccgtc ccagacacca aagttaactt     4290

ctatgcctgg aagaggatgg aggtcgggca gcaggctgta gaagtctggc agggcctggc     4350

cctgctctca gaagctgtcc tgcggggcca ggccgtgttg gccaactctt cccagccttt     4410

cgagcccctg cagctgcaca tggataaagc catcagtggc cttcgcagca tcaccactct     4470

gcttcgggcg ctgggagccc aggaagccat ctccctccca gatgcggcct cggctgctcc     4530

actccgaacc atcactgctg acactttctg caaactcttc cgagtctact ccaatttcct     4590

ccggggaaag ctgaagctgt acacggggga ggcctgcagg agaggggaca gatgaccatc     4650

gattacgcct aataaagagc tcagatgcat gcatcagagt gtgttggttt tttgtgtgtg     4710

gcgcgccgat cctcgagact agagcatggc tacgtagata agtagcatgg cgggttaatc     4770

attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4830

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     4890

gtgagcgagc gagcgcgcca                                                 4910


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Asp Tyr Pro Ala Ala Lys Arg Ala Arg Leu Asp Ser Arg 
1               5                   10              


<210>  24
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90              


<210>  25
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Glu Glu Phe Ser Pro Met Val Phe Ser Ser Gly Gln Ile Ser Ser Gln 
1               5                   10                  15      


Thr Ser Ala Leu Ala Ser Ala Pro Ala Pro Ala Pro Ile Leu Ala Pro 
            20                  25                  30          


Ala Pro Pro Ala Pro Ala Pro Ala Pro Ile Leu Ala Pro Gly Leu Ala 
        35                  40                  45              


Gln Ala Met Ala Pro Pro Ala Pro Lys Thr Thr Gln Ala Gly Glu Gly 
    50                  55                  60                  


Thr Leu Thr Glu Ala Leu Leu Gln Leu Gln Phe Asp Ala Asp Glu Asp 
65                  70                  75                  80  


Leu Gly Ala Leu Leu Gly Asn Ser Ala Asp Pro Ala Val Phe Thr Asp 
                85                  90                  95      


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
            100                 105                 110         


Val Ser Val Ala Pro His Thr Ala Glu Pro Met Leu Met Glu Tyr Pro 
        115                 120                 125             


Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro 
    130                 135                 140                 


Val Pro Ala Pro Val Gly Ala Ser Gly Leu Pro Asn Gly Leu Leu Ser 
145                 150                 155                 160 


Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu 
                165                 170                 175     


Leu Ser Gln Ile Ser Ser 
            180         


<210>  26
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Asp Tyr Pro Ala Ala Lys Arg Ala Arg Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Ser Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn 
    130                 135 


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  30
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  30
atggactatc ctgctgccaa gagggccaga ttggactcta gagaacgccc atatgcttgc       60

cctgtcgagt cctgcgatcg ccgcttttct cgctcggatg agcttacccg ccatatccgc      120

atccacacag gccagaagcc cttccagtgt cgaatctgca tgcgtaactt cagtcgtagt      180

gaccacctta ccacccacat ccgcacccac acaggcggcg gccgcaggag gaagaaacgc      240

accagcatag agaccaacat ccgtgtggcc ttagagaaga gtttcttgga gaatcaaaag      300

cctacctcgg aagagatcac tatgattgct gatcagctct ccatggaaaa agaggtgatt      360

cgtgtttggt tctgtaaccg ccgccagaaa gaaaaaagaa tcaac                      405


<210>  31
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  31
aatgatgggc gctcgagtaa tgatgggcgg tcgactaatg atgggcgctc gagtaatgat       60

gggcgtctag ctaatgatgg gcgctcgagt aatgatgggc ggtcgactaa tgatgggcgc      120

tcgagtaatg atgggcgtct agaac                                            145


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  32
aatgatgggc gctcgagt                                                     18


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  33
aatgatgggc ggtcgact                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  34
aatgatgggc gtctagct                                                     18


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  35
aatgatgggc gtctagaac                                                    19


<210>  36
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Ile Leu 
1               5                   10                  15      


Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr 
            20                  25                  30          


Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu 
        35                  40                  45              


His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe 
    50                  55                  60                  


Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg 
65                  70                  75                  80  


Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp 
                85                  90                  95      


Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Arg Glu Glu Phe 
            100                 105                 110         


Ser Pro Met Val Phe Pro Ser Gly Gln Ile Pro Ser Gln Thr Pro Ala 
        115                 120                 125             


Leu Ala Pro Ala Pro Ala Pro Ile Leu Ala Pro Ala Pro Ala Ser Val 
    130                 135                 140                 


Pro Ala Pro Ala Pro Val Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
145                 150                 155                 160 


Pro Ala Pro Ile Leu Ala Pro Gly Leu Ala Gln Ala Val Val Pro Pro 
                165                 170                 175     


Ala Pro Lys Thr Thr Gln Ala Gly Glu Gly Thr Leu Thr Glu Ala Leu 
            180                 185                 190         


Leu His Leu Gln Phe Asp Ala Asp Glu Asp Leu Gly Ala Leu Leu Gly 
        195                 200                 205             


Asn Ser Ala Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn 
    210                 215                 220                 


Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Val Ser Val Ala Pro His 
225                 230                 235                 240 


Pro Ala Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu 
                245                 250                 255     


Val Thr Gly Ser Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly 
            260                 265                 270         


Ala Ser Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser 
        275                 280                 285             


Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser 
    290                 295                 300                 


<210>  37
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Ser Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Arg Gly Val Gln Val Glu Thr Ile 
    130                 135                 140                 


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
145                 150                 155                 160 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
                165                 170                 175     


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
            180                 185                 190         


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
        195                 200                 205             


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
    210                 215                 220                 


Pro Gly Ile Ile Pro Pro Asn Ala Thr Leu Val Phe Asp Val Glu Leu 
225                 230                 235                 240 


Leu Lys Leu Glu Thr Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
                245                 250                 255     


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
            260                 265                 270         


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
        275                 280                 285             


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
    290                 295                 300                 


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
305                 310                 315                 320 


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
                325                 330                 335     


Ile Pro Pro Asn Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
            340                 345                 350         


Glu Thr Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
        355                 360                 365             


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
    370                 375                 380                 


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
385                 390                 395                 400 


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
                405                 410                 415     


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
            420                 425                 430         


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
        435                 440                 445             


Asn Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    450                 455                 460         


<210>  38
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Met Asp Tyr Pro Ala Ala Lys Arg Ala Arg Leu Asp Ser Arg Ile Leu 
1               5                   10                  15      


Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr 
            20                  25                  30          


Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu 
        35                  40                  45              


His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe 
    50                  55                  60                  


Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg 
65                  70                  75                  80  


Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp 
                85                  90                  95      


Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Arg Glu Glu Phe 
            100                 105                 110         


Ser Pro Met Val Phe Ser Ser Gly Gln Ile Ser Ser Gln Thr Ser Ala 
        115                 120                 125             


Leu Ala Ser Ala Pro Ala Pro Ala Pro Ile Leu Ala Pro Ala Pro Pro 
    130                 135                 140                 


Ala Pro Ala Pro Ala Pro Ile Leu Ala Pro Gly Leu Ala Gln Ala Met 
145                 150                 155                 160 


Ala Pro Pro Ala Pro Lys Thr Thr Gln Ala Gly Glu Gly Thr Leu Thr 
                165                 170                 175     


Glu Ala Leu Leu Gln Leu Gln Phe Asp Ala Asp Glu Asp Leu Gly Ala 
            180                 185                 190         


Leu Leu Gly Asn Ser Ala Asp Pro Ala Val Phe Thr Asp Leu Ala Ser 
        195                 200                 205             


Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Val Ser Val 
    210                 215                 220                 


Ala Pro His Thr Ala Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile 
225                 230                 235                 240 


Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro Val Pro Ala 
                245                 250                 255     


Pro Val Gly Ala Ser Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu 
            260                 265                 270         


Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln 
        275                 280                 285             


Ile Ser Ser 
    290     


<210>  39
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39

Met Asp Tyr Pro Ala Ala Lys Arg Ala Arg Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Ser Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Arg Gly Val Gln Val Glu Thr Ile 
    130                 135                 140                 


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
145                 150                 155                 160 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
                165                 170                 175     


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
            180                 185                 190         


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
        195                 200                 205             


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
    210                 215                 220                 


Pro Gly Ile Ile Pro Pro Asn Ala Thr Leu Val Phe Asp Val Glu Leu 
225                 230                 235                 240 


Leu Lys Leu Glu Thr Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
                245                 250                 255     


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
            260                 265                 270         


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
        275                 280                 285             


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
    290                 295                 300                 


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
305                 310                 315                 320 


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
                325                 330                 335     


Ile Pro Pro Asn Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
            340                 345                 350         


Glu Thr Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
        355                 360                 365             


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
    370                 375                 380                 


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
385                 390                 395                 400 


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
                405                 410                 415     


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
            420                 425                 430         


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
        435                 440                 445             


Asn Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    450                 455                 460         


