                         SEQUENCE LISTING

<110>  ProMab Biotechnologies, Inc.
       Forevertek Biotechnology Co., Ltd.
       WU, Lijun
       GOLUBOVSKAYA, Vita
 
<120>  HUMANIZED CD37 AND BI-SPECIFIC CD19-HUMANIZED CD37 CAR-T CELLS

<130>  119995-8035.WO01

<150>  63/056,899
<151>  2020-07-27

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  1
gaagtacaac tcgtcgagtc cggcggggga ctggtacagc ccggacggtc cctgagactt       60

agttgtacgg cttctggttt cacgttttcc gactattgga tgaattgggt gaggcaagcg      120

cccggtaaag gcctggaatg ggtgggacaa attcgcgata agccgtataa ttacgaaaca      180

ttctacagcg actctgtcaa gggtagattc acaatctccc gggatgacag taaatccatt      240

gcatacctcc agatgaactc tctcaaaacc gaggatacag ctgtatatta ttgcactggg      300

agtttcgcct actggggagc tgggacgacg gtaacggtat cctcaggtgg cggtggaagc      360

ggtggtggag gtagtggagg gggtgggagt gccattagga tgactcagag ccccagttct      420

ttcagtgcat caacaggaga cagagtaacg ataacgtgcc gggcaagcgg taacatccat      480

aattaccttg cgtggtacca acagaaacct ggtaaagcgc cgaaacttct catttacaat      540

gctaagaccc ttccctccgg agttccctct aggtttagtg gctcaggtag cgggaccgac      600

tttaccttga caatcagttg cctgcaatca gaagactttg caacttacta ctgccaacag      660

tattggagca ccccctatac gtttggcggc ggtactaaac tggaaatccg c               711


<210>  2
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gln Ile Arg Asp Lys Pro Tyr Asn Tyr Glu Thr Phe Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ser Phe Ala Tyr Trp Gly Ala Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser 
    130                 135                 140                 


Thr Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His 
145                 150                 155                 160 


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Asn Ala Lys Thr Leu Pro Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Cys Leu 
        195                 200                 205             


Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
225                 230                 235         


<210>  3
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gln Ile Arg Asp Lys Pro Tyr Asn Tyr Glu Thr Phe Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ser Phe Ala Tyr Trp Gly Ala Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  4
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Cys Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105         


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  6
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  6
caggtgcagc ttgtcgagag tggaggtggc gtcgttcaac ctggtagaag tttgcggctc       60

tcatgtgcgg cctctggatt tactttttct gactactgga tgaactgggt caggcaagct      120

ccaggtaagg ggcttgaatg ggtggcgcag atccgggata agccatacaa ctacgagacg      180

ttctactcag acagtgtaaa gggcagattt actataagta gagataattc aaagaacacg      240

ctctatcttc agatgaattc attgagagcg gaggacacgg cggtgtacta ctgtactggc      300

agctttgcgt actggggagc tgggacaacg gtaacggtat cttctggagg aggaggtagt      360

ggcgggggtg gctctggagg tggcggctct gatatacaaa tgactcaaag tccatctagt      420

ctcagcgcca gcgtgggcga cagggtcact ataacgtgtc gagcgtctgg caatatacac      480

aattacttgg cgtggtatca gcaaaaaccg ggaaaagcgc cgaagctgct catatataat      540

gcgaaaactt tgccatcagg cgttccttcc cggttctcag gctccggttc tggaacggac      600

tttactctca ctatcagtag ccttcagcca gaggacttcg ccacttacta ttgccagcaa      660

tattggtcta ctccttacac ctttggggga gggaccaaat tggaaatccg c               711


<210>  7
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Ile Arg Asp Lys Pro Tyr Asn Tyr Glu Thr Phe Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ser Phe Ala Tyr Trp Gly Ala Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His 
145                 150                 155                 160 


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Asn Ala Lys Thr Leu Pro Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
225                 230                 235         


<210>  8
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Ile Arg Asp Lys Pro Tyr Asn Tyr Glu Thr Phe Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ser Phe Ala Tyr Trp Gly Ala Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  9
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105         


<210>  10
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  10
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggctagc                                                               69


<210>  11
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser 
            20              


<210>  12
<211>  135
<212>  DNA
<213>  Homo sapiens

<400>  12
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgag ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcca gtgat                                                       135


<210>  13
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
        35                  40                  45  


<210>  14
<211>  87
<212>  DNA
<213>  Homo sapiens

<400>  14
aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta       60

acagtggcct ttattatttt ctgggtg                                           87


<210>  15
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  15

Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
1               5                   10                  15      


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25                  


<210>  16
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  16
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  17
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  17

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  18
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  18
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                         342


<210>  19
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  20
<211>  1482
<212>  DNA
<213>  Homo sapiens

<400>  20
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggctagcg aagtacaact cgtcgagtcc ggcgggggac tggtacagcc cggacggtcc      120

ctgagactta gttgtacggc ttctggtttc acgttttccg actattggat gaattgggtg      180

aggcaagcgc ccggtaaagg cctggaatgg gtgggacaaa ttcgcgataa gccgtataat      240

tacgaaacat tctacagcga ctctgtcaag ggtagattca caatctcccg ggatgacagt      300

aaatccattg catacctcca gatgaactct ctcaaaaccg aggatacagc tgtatattat      360

tgcactggga gtttcgccta ctggggagct gggacgacgg taacggtatc ctcaggtggc      420

ggtggaagcg gtggtggagg tagtggaggg ggtgggagtg ccattaggat gactcagagc      480

cccagttctt tcagtgcatc aacaggagac agagtaacga taacgtgccg ggcaagcggt      540

aacatccata attaccttgc gtggtaccaa cagaaacctg gtaaagcgcc gaaacttctc      600

atttacaatg ctaagaccct tccctccgga gttccctcta ggtttagtgg ctcaggtagc      660

gggaccgact ttaccttgac aatcagttgc ctgcaatcag aagactttgc aacttactac      720

tgccaacagt attggagcac cccctatacg tttggcggcg gtactaaact ggaaatccgc      780

ctcgagaagc ccaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg agccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc cagtgataag cccttttggg tgctggtggt ggttggtgga      960

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        1482


<210>  21
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Asp Tyr Trp Met Asn Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Gly Gln Ile Arg Asp Lys Pro Tyr Asn 
65                  70                  75                  80  


Tyr Glu Thr Phe Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys 
            100                 105                 110         


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Gly Ser Phe Ala Tyr Trp 
        115                 120                 125             


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Phe Ser Ala Ser Thr Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Lys Thr Leu Pro 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Cys Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Tyr Trp Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Arg Leu Glu Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Ser Asp Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  22
<211>  1482
<212>  DNA
<213>  Homo sapiens

<400>  22
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggctagcc aggtgcagct tgtcgagagt ggaggtggcg tcgttcaacc tggtagaagt      120

ttgcggctct catgtgcggc ctctggattt actttttctg actactggat gaactgggtc      180

aggcaagctc caggtaaggg gcttgaatgg gtggcgcaga tccgggataa gccatacaac      240

tacgagacgt tctactcaga cagtgtaaag ggcagattta ctataagtag agataattca      300

aagaacacgc tctatcttca gatgaattca ttgagagcgg aggacacggc ggtgtactac      360

tgtactggca gctttgcgta ctggggagct gggacaacgg taacggtatc ttctggagga      420

ggaggtagtg gcgggggtgg ctctggaggt ggcggctctg atatacaaat gactcaaagt      480

ccatctagtc tcagcgccag cgtgggcgac agggtcacta taacgtgtcg agcgtctggc      540

aatatacaca attacttggc gtggtatcag caaaaaccgg gaaaagcgcc gaagctgctc      600

atatataatg cgaaaacttt gccatcaggc gttccttccc ggttctcagg ctccggttct      660

ggaacggact ttactctcac tatcagtagc cttcagccag aggacttcgc cacttactat      720

tgccagcaat attggtctac tccttacacc tttgggggag ggaccaaatt ggaaatccgc      780

ctcgagaagc ccaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg agccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc cagtgataag cccttttggg tgctggtggt ggttggtgga      960

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctctac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        1482


<210>  23
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Asp Tyr Trp Met Asn Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Ala Gln Ile Arg Asp Lys Pro Tyr Asn 
65                  70                  75                  80  


Tyr Glu Thr Phe Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            100                 105                 110         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Gly Ser Phe Ala Tyr Trp 
        115                 120                 125             


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Lys Thr Leu Pro 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Tyr Trp Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Arg Leu Glu Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Ser Asp Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  24
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  24
atgctgctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg       60

atcccc                                                                  66


<210>  25
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  26
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  26
gacatccaga tgacccagac caccagcagc ctgagcgcca gcctgggcga tagagtgacc       60

atcagctgca gagccagcca ggacatcagc aagtacctga actggtatca gcagaaaccc      120

gacggcaccg tgaagctgct gatctaccac accagcagac tgcacagcgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggaacag      240

gaagatatcg ctacgtactt ttgtcagcag ggaaacacgc ttccatacac cttcggcggc      300

ggtacgaagt tggagatcac g                                                321


<210>  27
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  27

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  28
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  28
gaggtcaaac tgcaggaatc cggaccaggg cttgtagccc cctcacaaag cctcagcgtg       60

acttgtacag tgagcggcgt tagtctgccg gactatggag tttcttggat tcggcaaccg      120

cccagaaaag ggctggaatg gcttggtgtt atatggggct cagaaactac ctattacaac      180

agtgctctca aaagccggct cacaataata aaggataata gcaaatctca agttttcctg      240

aaaatgaact ctctgcaaac agatgacacg gcgatctact actgcgcgaa acactactat      300

tacggcggca gctacgccat ggactattgg gggcagggga cgtcagtgac agtgtctagc      360


<210>  29
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  29

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  135
<212>  DNA
<213>  Homo sapiens

<400>  30
accacgacgc ccgcccctag acccccgacg cccgctccga ctatagcgag ccaacctctc       60

agcctgaggc ctgaagcatg tcgaccagca gcaggagggg cagtacacac caggggcctg      120

gattttgcct gtgat                                                       135


<210>  31
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  31

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  32
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  32
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  33
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  33

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  34
<211>  2166
<212>  DNA
<213>  Homo sapiens

<400>  34
atgctgctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg       60

atccccgaca tccagatgac ccagaccacc agcagcctga gcgccagcct gggcgataga      120

gtgaccatca gctgcagagc cagccaggac atcagcaagt acctgaactg gtatcagcag      180

aaacccgacg gcaccgtgaa gctgctgatc taccacacca gcagactgca cagcggcgtg      240

cccagcagat tttctggcag cggctccggc accgactaca gcctgaccat ctccaacctg      300

gaacaggaag atatcgctac gtacttttgt cagcagggaa acacgcttcc atacaccttc      360

ggcggcggta cgaagttgga gatcacgggc ggaggaggga gtgaagtaca actcgtcgag      420

tccggcgggg gactggtaca gcccggacgg tccctgagac ttagttgtac ggcttctggt      480

ttcacgtttt ccgactattg gatgaattgg gtgaggcaag cgcccggtaa aggcctggaa      540

tgggtgggac aaattcgcga taagccgtat aattacgaaa cattctacag cgactctgtc      600

aagggtagat tcacaatctc ccgggatgac agtaaatcca ttgcatacct ccagatgaac      660

tctctcaaaa ccgaggatac agctgtatat tattgcactg ggagtttcgc ctactgggga      720

gctgggacga cggtaacggt atcctcaggt ggcggtggaa gcggtggtgg aggtagtgga      780

gggggtggga gtgccattag gatgactcag agccccagtt ctttcagtgc atcaacagga      840

gacagagtaa cgataacgtg ccgggcaagc ggtaacatcc ataattacct tgcgtggtac      900

caacagaaac ctggtaaagc gccgaaactt ctcatttaca atgctaagac ccttccctcc      960

ggagttccct ctaggtttag tggctcaggt agcgggaccg actttacctt gacaatcagt     1020

tgcctgcaat cagaagactt tgcaacttac tactgccaac agtattggag caccccctat     1080

acgtttggcg gcggtactaa actggaaatc cgcggtggtg gagggagcga ggtcaaactg     1140

caggaatccg gaccagggct tgtagccccc tcacaaagcc tcagcgtgac ttgtacagtg     1200

agcggcgtta gtctgccgga ctatggagtt tcttggattc ggcaaccgcc cagaaaaggg     1260

ctggaatggc ttggtgttat atggggctca gaaactacct attacaacag tgctctcaaa     1320

agccggctca caataataaa ggataatagc aaatctcaag ttttcctgaa aatgaactct     1380

ctgcaaacag atgacacggc gatctactac tgcgcgaaac actactatta cggcggcagc     1440

tacgccatgg actattgggg gcaggggacg tcagtgacag tgtctagcag cgggaccacg     1500

acgcccgccc ctagaccccc gacgcccgct ccgactatag cgagccaacc tctcagcctg     1560

aggcctgaag catgtcgacc agcagcagga ggggcagtac acaccagggg cctggatttt     1620

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca     1680

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1740

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1800

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1860

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1920

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1980

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     2040

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     2100

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     2160

cgctaa                                                                2166


<210>  35
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Asp Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Gly Gln Ile Arg Asp Lys Pro Tyr Asn Tyr 
            180                 185                 190         


Glu Thr Phe Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Gly Ser Phe Ala Tyr Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met Thr Gln Ser Pro 
            260                 265                 270         


Ser Ser Phe Ser Ala Ser Thr Gly Asp Arg Val Thr Ile Thr Cys Arg 
        275                 280                 285             


Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
    290                 295                 300                 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Lys Thr Leu Pro Ser 
305                 310                 315                 320 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                325                 330                 335     


Leu Thr Ile Ser Cys Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Gln Gln Tyr Trp Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        355                 360                 365             


Glu Ile Arg Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly 
    370                 375                 380                 


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val 
385                 390                 395                 400 


Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
                405                 410                 415     


Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr 
            420                 425                 430         


Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp 
        435                 440                 445             


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
    450                 455                 460                 


Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser 
465                 470                 475                 480 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                485                 490                 495     


Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            500                 505                 510         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        515                 520                 525             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    530                 535                 540                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
545                 550                 555                 560 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                565                 570                 575     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            580                 585                 590         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        595                 600                 605             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    610                 615                 620                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
625                 630                 635                 640 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                645                 650                 655     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            660                 665                 670         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        675                 680                 685             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    690                 695                 700                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
705                 710                 715                 720 


Arg 
    


<210>  36
<211>  2166
<212>  DNA
<213>  Homo sapiens

<400>  36
atgctgctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg       60

atccccgaca tccagatgac ccagaccacc agcagcctga gcgccagcct gggcgataga      120

gtgaccatca gctgcagagc cagccaggac atcagcaagt acctgaactg gtatcagcag      180

aaacccgacg gcaccgtgaa gctgctgatc taccacacca gcagactgca cagcggcgtg      240

cccagcagat tttctggcag cggctccggc accgactaca gcctgaccat ctccaacctg      300

gaacaggaag atatcgctac gtacttttgt cagcagggaa acacgcttcc atacaccttc      360

ggcggcggta cgaagttgga gatcacgggc ggaggaggga gtcaggtgca gcttgtcgag      420

agtggaggtg gcgtcgttca acctggtaga agtttgcggc tctcatgtgc ggcctctgga      480

tttacttttt ctgactactg gatgaactgg gtcaggcaag ctccaggtaa ggggcttgaa      540

tgggtggcgc agatccggga taagccatac aactacgaga cgttctactc agacagtgta      600

aagggcagat ttactataag tagagataat tcaaagaaca cgctctatct tcagatgaat      660

tcattgagag cggaggacac ggcggtgtac tactgtactg gcagctttgc gtactgggga      720

gctgggacaa cggtaacggt atcttctgga ggaggaggta gtggcggggg tggctctgga      780

ggtggcggct ctgatataca aatgactcaa agtccatcta gtctcagcgc cagcgtgggc      840

gacagggtca ctataacgtg tcgagcgtct ggcaatatac acaattactt ggcgtggtat      900

cagcaaaaac cgggaaaagc gccgaagctg ctcatatata atgcgaaaac tttgccatca      960

ggcgttcctt cccggttctc aggctccggt tctggaacgg actttactct cactatcagt     1020

agccttcagc cagaggactt cgccacttac tattgccagc aatattggtc tactccttac     1080

acctttgggg gagggaccaa attggaaatc cgcggtggtg gagggagcga ggtcaaactg     1140

caggaatccg gaccagggct tgtagccccc tcacaaagcc tcagcgtgac ttgtacagtg     1200

agcggcgtta gtctgccgga ctatggagtt tcttggattc ggcaaccgcc cagaaaaggg     1260

ctggaatggc ttggtgttat atggggctca gaaactacct attacaacag tgctctcaaa     1320

agccggctca caataataaa ggataatagc aaatctcaag ttttcctgaa aatgaactct     1380

ctgcaaacag atgacacggc gatctactac tgcgcgaaac actactatta cggcggcagc     1440

tacgccatgg actattgggg gcaggggacg tcagtgacag tgtctagcag cgggaccacg     1500

acgcccgccc ctagaccccc gacgcccgct ccgactatag cgagccaacc tctcagcctg     1560

aggcctgaag catgtcgacc agcagcagga ggggcagtac acaccagggg cctggatttt     1620

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca     1680

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1740

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1800

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1860

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1920

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1980

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     2040

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     2100

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     2160

cgctaa                                                                2166


<210>  37
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Asp Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Ala Gln Ile Arg Asp Lys Pro Tyr Asn Tyr 
            180                 185                 190         


Glu Thr Phe Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Gly Ser Phe Ala Tyr Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            260                 265                 270         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
        275                 280                 285             


Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
    290                 295                 300                 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Lys Thr Leu Pro Ser 
305                 310                 315                 320 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                325                 330                 335     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Gln Gln Tyr Trp Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        355                 360                 365             


Glu Ile Arg Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly 
    370                 375                 380                 


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val 
385                 390                 395                 400 


Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
                405                 410                 415     


Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr 
            420                 425                 430         


Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp 
        435                 440                 445             


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
    450                 455                 460                 


Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser 
465                 470                 475                 480 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                485                 490                 495     


Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            500                 505                 510         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        515                 520                 525             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    530                 535                 540                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
545                 550                 555                 560 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                565                 570                 575     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            580                 585                 590         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        595                 600                 605             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    610                 615                 620                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
625                 630                 635                 640 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                645                 650                 655     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            660                 665                 670         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        675                 680                 685             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    690                 695                 700                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
705                 710                 715                 720 


Arg 
    


