                         SEQUENCE LISTING

<110>  Evvivax S.r.l.
 
<120>  CONSENSUS SEQUENCE OF TELOMERASE ANTIGEN AND ITS USE IN 
       PREVENTIVE AND THERAPEUTIC VACCINATION

<130>  PCT45012

<150>  IT 102020000018379
<151>  2020-07-29

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  1139
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence of telomerase antigen

<400>  1

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ala Leu Leu Arg Ser 
1               5                   10                  15      


Arg Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Leu Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Arg Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Gly Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Val Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Thr Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Leu 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Pro Thr Ser Leu Arg Pro Pro Pro Pro Ala Ser Pro 
            180                 185                 190         


Pro Arg Arg Arg Leu Pro Gly Leu Arg Ala Trp Asn His Ala Val Arg 
        195                 200                 205             


Asp Leu Arg Val Thr Arg Gln Leu Gln Asn Ser Gly Ala Arg Arg Arg 
    210                 215                 220                 


Arg Gly Ser Pro Ser Ser Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Ser Val Ala Ser Glu Pro Glu Arg Thr Pro Val Gly Arg Gly Ala Trp 
                245                 250                 255     


Arg Ser Pro Pro Arg Thr Arg Gln Pro Ser Val Ser Gly Phe Pro Val 
            260                 265                 270         


Val Ser Pro Ala Val Pro Ala Ser Pro Ala Thr Ser Trp Glu Gly Ala 
        275                 280                 285             


Pro Ser Gly Thr Arg Pro Ser Thr Pro Ala Trp Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Tyr Pro Arg Pro Trp Gly Val Pro 
305                 310                 315                 320 


His Pro Pro Val His Pro Glu Thr Lys Arg Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Gly Lys Glu Arg Leu Arg Pro Ser Phe Leu Leu Ser Ala Leu Arg Pro 
            340                 345                 350         


Ser Leu Ser Gly Ala Arg Lys Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Arg Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Arg Met Arg Pro Leu Phe Gln Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Arg Cys Pro Tyr Arg Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Met Val Thr Pro Glu Ala Ser Val Asn Gln Arg His Lys Gly Val 
            420                 425                 430         


Gly Ile Cys Pro Gln Gly Ser Val Val Ala Pro Pro Gln Glu Gln Thr 
        435                 440                 445             


Asp Ser Thr Arg Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp 
    450                 455                 460                 


Gln Val Tyr Ala Phe Leu Arg Ala Cys Leu Arg Trp Leu Val Pro Thr 
465                 470                 475                 480 


Gly Leu Trp Gly Ser Arg His Asn Gln Arg Arg Phe Leu Arg Asn Val 
                485                 490                 495     


Lys Lys Phe Ile Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu 
            500                 505                 510         


Leu Thr Trp Lys Met Ser Val Arg Asp Cys Thr Trp Leu Arg Arg Ser 
        515                 520                 525             


Pro Gly Val Gly Cys Val Pro Ala Ala Glu His Arg Arg Arg Glu Glu 
    530                 535                 540                 


Ile Leu Ala Lys Phe Leu Val Trp Leu Met Ser His Ile Tyr Val Val 
545                 550                 555                 560 


Lys Leu Leu Arg Ser Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys 
                565                 570                 575     


Asn Arg Leu Phe Phe Tyr Arg Lys Ser Val Trp Ser Gln Leu Gln Ser 
            580                 585                 590         


Ile Gly Ile Arg Gln Leu Leu Asn Ser Val Gln Leu Arg Glu Leu Ser 
        595                 600                 605             


Glu Ala Glu Val Arg Arg His Arg Glu Ala Arg Pro Ala Leu Leu Thr 
    610                 615                 620                 


Ser Arg Leu Arg Phe Ile Pro Lys Pro Ser Gly Leu Arg Pro Ile Val 
625                 630                 635                 640 


Asn Met Asp Tyr Ile Met Gly Ala Arg Thr Phe Arg Arg Asp Lys Lys 
                645                 650                 655     


Val Gln Arg Leu Thr Ser Arg Leu Lys Thr Leu Phe Ser Val Leu Asn 
            660                 665                 670         


Tyr Glu Arg Ala Arg Arg Pro Ser Leu Leu Gly Ala Ser Met Leu Gly 
        675                 680                 685             


Leu Asp Asp Ile His Arg Ala Trp Arg Thr Phe Val Leu Arg Ile Arg 
    690                 695                 700                 


Ala Gln Asn Pro Pro Pro Gln Leu Tyr Phe Val Lys Val Ala Ile Thr 
705                 710                 715                 720 


Gly Ala Tyr Asp Thr Ile Pro Gln Asp Arg Leu Val Glu Val Ile Ala 
                725                 730                 735     


Ser Ile Ile Lys Pro Gln Glu Ser Thr Tyr Cys Val Arg Arg Tyr Ala 
            740                 745                 750         


Val Val Gln Lys Thr Ala Arg Gly His Val Arg Lys Ala Phe Lys Ser 
        755                 760                 765             


His Val Ser Thr Leu Thr Asp Leu Gln Pro Tyr Met Arg Gln Phe Val 
    770                 775                 780                 


Glu Arg Leu Gln Glu Thr Ser Pro Leu Arg Asp Ala Val Val Ile Glu 
785                 790                 795                 800 


Gln Ser Ser Ser Leu Asn Glu Ala Ser Ser Ser Leu Phe His Leu Phe 
                805                 810                 815     


Leu Arg Leu Met His Asn His Val Val Arg Ile Arg Gly Lys Ser Tyr 
            820                 825                 830         


Ile Gln Cys Gln Gly Ile Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu 
        835                 840                 845             


Cys Ser Leu Cys Tyr Gly Asp Met Glu Arg Lys Leu Phe Pro Gly Ile 
    850                 855                 860                 


Arg Arg Asp Gly Leu Leu Leu Arg Leu Val Asp Asp Phe Leu Leu Val 
865                 870                 875                 880 


Thr Pro His Leu Thr Gln Ala Gln Thr Phe Leu Arg Thr Leu Val Lys 
                885                 890                 895     


Gly Val Pro Glu Tyr Gly Cys Val Val Asn Leu Arg Lys Thr Val Val 
            900                 905                 910         


Asn Phe Pro Val Glu Asp Gly Ala Leu Gly Ser Thr Ala Pro Leu Gln 
        915                 920                 925             


Leu Pro Ala His Gly Leu Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr 
    930                 935                 940                 


Arg Thr Leu Glu Val Ser Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser 
945                 950                 955                 960 


Ile Arg Ala Ser Leu Thr Phe Ser Arg Gly Phe Lys Pro Gly Arg Asn 
                965                 970                 975     


Met Arg Arg Lys Leu Leu Ala Val Leu Arg Leu Lys Cys His Ala Leu 
            980                 985                 990         


Phe Leu Asp Leu Gln Val Asn Ser  Ile Gln Thr Val Tyr  Thr Asn Ile 
        995                 1000                 1005             


Tyr Lys  Ile Leu Leu Leu Gln  Ala Tyr Arg Phe His  Ala Cys Val 
    1010                 1015                 1020             


Leu Gln  Leu Pro Phe Asn Gln  Gln Val Trp Lys Asn  Pro Ser Phe 
    1025                 1030                 1035             


Phe Leu  Arg Val Ile Ala Asp  Thr Ala Ser Leu Cys  Tyr Ser Ile 
    1040                 1045                 1050             


Leu Lys  Ala Lys Asn Ala Gly  Leu Ser Leu Gly Ala  Lys Gly Ala 
    1055                 1060                 1065             


Ala Gly  Pro Leu Pro Ser Glu  Ala Val Arg Trp Leu  Cys Leu Gln 
    1070                 1075                 1080             


Ala Phe  Leu Leu Lys Leu Thr  Arg His Ser Val Thr  Tyr Val Pro 
    1085                 1090                 1095             


Leu Leu  Gly Ala Leu Arg Thr  Ala Gln Thr Gln Leu  Ser Arg Gln 
    1100                 1105                 1110             


Leu Pro  Arg Thr Thr Leu Thr  Ala Leu Glu Ala Ala  Ala Asn Pro 
    1115                 1120                 1125             


Ala Leu  Thr Ala Asp Phe Lys  Thr Ile Leu Asp Met Pro Arg Ala Pro 
    1130                 1135                 1               5   


Arg Cys Arg Ala Val Arg Ala Leu Leu Arg Ser Arg Tyr Arg Glu Val 
                10                  15                  20      


Leu Pro Leu Ala Thr Phe Leu Arg Arg Leu Gly Pro Gln Gly Trp Arg 
            25                  30                  35          


Leu Val Arg Arg Gly Asp Pro Ala Ala Phe Arg Ala Leu Val Ala Gln 
        40                  45                  50              


Cys Leu Val Cys Val Pro Trp Gly Ala Arg Pro Pro Pro Ala Ala Pro 
    55                  60                  65                  


Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu Val Ala Arg Val Leu 
70                  75                  80                  85  


Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val Leu Ala Phe Gly Phe 
                90                  95                  100     


Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro Val Ala Phe Thr Thr 
            105                 110                 115         


Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr Asp Thr Leu Arg Gly 
        120                 125                 130             


Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val Gly Asp Asp Val Leu 
    135                 140                 145                 


Val His Leu Leu Ala Arg Cys Ala Leu Phe Leu Leu Val Ala Pro Ser 
150                 155                 160                 165 


Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr Gln Leu Gly Ala Pro 
                170                 175                 180     


Thr Ser Leu Arg Pro Pro Pro Pro Ala Ser Pro Pro Arg Arg Arg Leu 
            185                 190                 195         


Pro Gly Leu Arg Ala Trp Asn His Ala Val Arg Asp Leu Arg Val Thr 
        200                 205                 210             


Arg Gln Leu Gln Asn Ser Gly Ala Arg Arg Arg Arg Gly Ser Pro Ser 
    215                 220                 225                 


Ser Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg Ser Val Ala Ser Glu 
230                 235                 240                 245 


Pro Glu Arg Thr Pro Val Gly Arg Gly Ala Trp Arg Ser Pro Pro Arg 
                250                 255                 260     


Thr Arg Gln Pro Ser Val Ser Gly Phe Pro Val Val Ser Pro Ala Val 
            265                 270                 275         


Pro Ala Ser Pro Ala Thr Ser Trp Glu Gly Ala Pro Ser Gly Thr Arg 
        280                 285                 290             


Pro Ser Thr Pro Ala Trp Gly Arg Gln His His Ala Gly Pro Pro Ser 
    295                 300                 305                 


Thr Ser Arg Tyr Pro Arg Pro Trp Gly Val Pro His Pro Pro Val His 
310                 315                 320                 325 


Pro Glu Thr Lys Arg Phe Leu Tyr Ser Ser Gly Gly Lys Glu Arg Leu 
                330                 335                 340     


Arg Pro Ser Phe Leu Leu Ser Ala Leu Arg Pro Ser Leu Ser Gly Ala 
            345                 350                 355         


Arg Lys Leu Val Glu Thr Ile Phe Leu Gly Ser Arg Pro Trp Met Pro 
        360                 365                 370             


Gly Thr Pro Arg Arg Leu Arg Arg Leu Pro Gln Arg Tyr Trp Arg Met 
    375                 380                 385                 


Arg Pro Leu Phe Gln Glu Leu Leu Gly Asn His Ala Arg Cys Pro Tyr 
390                 395                 400                 405 


Arg Val Leu Leu Lys Thr His Cys Pro Leu Arg Ala Met Val Thr Pro 
                410                 415                 420     


Glu Ala Ser Val Asn Gln Arg His Lys Gly Val Gly Ile Cys Pro Gln 
            425                 430                 435         


Gly Ser Val Val Ala Pro Pro Gln Glu Gln Thr Asp Ser Thr Arg Leu 
        440                 445                 450             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Ala Phe 
    455                 460                 465                 


Leu Arg Ala Cys Leu Arg Trp Leu Val Pro Thr Gly Leu Trp Gly Ser 
470                 475                 480                 485 


Arg His Asn Gln Arg Arg Phe Leu Arg Asn Val Lys Lys Phe Ile Ser 
                490                 495                 500     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            505                 510                 515         


Ser Val Arg Asp Cys Thr Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        520                 525                 530             


Val Pro Ala Ala Glu His Arg Arg Arg Glu Glu Ile Leu Ala Lys Phe 
    535                 540                 545                 


Leu Val Trp Leu Met Ser His Ile Tyr Val Val Lys Leu Leu Arg Ser 
550                 555                 560                 565 


Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe 
                570                 575                 580     


Tyr Arg Lys Ser Val Trp Ser Gln Leu Gln Ser Ile Gly Ile Arg Gln 
            585                 590                 595         


Leu Leu Asn Ser Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg 
        600                 605                 610             


Arg His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe 
    615                 620                 625                 


Ile Pro Lys Pro Ser Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Ile 
630                 635                 640                 645 


Met Gly Ala Arg Thr Phe Arg Arg Asp Lys Lys Val Gln Arg Leu Thr 
                650                 655                 660     


Ser Arg Leu Lys Thr Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg 
            665                 670                 675         


Arg Pro Ser Leu Leu Gly Ala Ser Met Leu Gly Leu Asp Asp Ile His 
        680                 685                 690             


Arg Ala Trp Arg Thr Phe Val Leu Arg Ile Arg Ala Gln Asn Pro Pro 
    695                 700                 705                 


Pro Gln Leu Tyr Phe Val Lys Val Ala Ile Thr Gly Ala Tyr Asp Thr 
710                 715                 720                 725 


Ile Pro Gln Asp Arg Leu Val Glu Val Ile Ala Ser Ile Ile Lys Pro 
                730                 735                 740     


Gln Glu Ser Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Thr 
            745                 750                 755         


Ala Arg Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu 
        760                 765                 770             


Thr Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Glu Arg Leu Gln Glu 
    775                 780                 785                 


Thr Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu 
790                 795                 800                 805 


Asn Glu Ala Ser Ser Ser Leu Phe His Leu Phe Leu Arg Leu Met His 
                810                 815                 820     


Asn His Val Val Arg Ile Arg Gly Lys Ser Tyr Ile Gln Cys Gln Gly 
            825                 830                 835         


Ile Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr 
        840                 845                 850             


Gly Asp Met Glu Arg Lys Leu Phe Pro Gly Ile Arg Arg Asp Gly Leu 
    855                 860                 865                 


Leu Leu Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr 
870                 875                 880                 885 


Gln Ala Gln Thr Phe Leu Arg Thr Leu Val Lys Gly Val Pro Glu Tyr 
                890                 895                 900     


Gly Cys Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu 
            905                 910                 915         


Asp Gly Ala Leu Gly Ser Thr Ala Pro Leu Gln Leu Pro Ala His Gly 
        920                 925                 930             


Leu Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val 
    935                 940                 945                 


Ser Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu 
950                 955                 960                 965 


Thr Phe Ser Arg Gly Phe Lys Pro Gly Arg Asn Met Arg Arg Lys Leu 
                970                 975                 980     


Leu Ala Val Leu Arg Leu Lys Cys His Ala Leu Phe Leu Asp Leu Gln 
            985                 990                 995         


Val Asn Ser  Ile Gln Thr Val Tyr  Thr Asn Ile Tyr Lys  Ile Leu 
        1000                 1005                 1010         


Leu Leu Gln  Ala Tyr Arg Phe His  Ala Cys Val Leu Gln  Leu Pro 
        1015                 1020                 1025         


Phe Asn Gln  Gln Val Trp Lys Asn  Pro Ser Phe Phe Leu  Arg Val 
        1030                 1035                 1040         


Ile Ala Asp  Thr Ala Ser Leu Cys  Tyr Ser Ile Leu Lys  Ala Lys 
        1045                 1050                 1055         


Asn Ala Gly  Leu Ser Leu Gly Ala  Lys Gly Ala Ala Gly  Pro Leu 
        1060                 1065                 1070         


Pro Ser Glu  Ala Val Arg Trp Leu  Cys Leu Gln Ala Phe  Leu Leu 
        1075                 1080                 1085         


Lys Leu Thr  Arg His Ser Val Thr  Tyr Val Pro Leu Leu  Gly Ala 
        1090                 1095                 1100         


Leu Arg Thr  Ala Gln Thr Gln Leu  Ser Arg Gln Leu Pro  Arg Thr 
        1105                 1110                 1115         


Thr Leu Thr  Ala Leu Glu Ala Ala  Ala Asn Pro Ala Leu  Thr Ala 
        1120                 1125                 1130         


Asp Phe Lys  Thr Ile Leu Asp 
        1135                 


<210>  2
<211>  1122
<212>  PRT
<213>  Artificial

<220>
<223>  chimeric fusion protein of dog and human telomerase

<400>  2

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ala Leu Leu Arg Gly 
1               5                   10                  15      


Arg Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Leu Arg Arg Leu Gly 
            20                  25                  30          


Pro Pro Gly Arg Leu Leu Val Arg Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Gly Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Cys Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Val Gln Arg Leu Cys Glu Arg Gly Ala Arg Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Val Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Glu Thr Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Thr His Leu Leu Ala Arg Cys Ala Leu Tyr Leu 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Asp Leu Cys Ala Pro Ala Ser Leu Pro Leu Pro Ala Pro Gly Leu Pro 
            180                 185                 190         


Gly Leu Pro Gly Leu Pro Gly Leu Gly Ala Gly Ala Gly Ala Ser Ala 
        195                 200                 205             


Asp Leu Arg Pro Thr Arg Gln Ala Gln Asn Ser Gly Ala Arg Arg Arg 
    210                 215                 220                 


Arg Gly Ser Pro Gly Ser Gly Val Pro Leu Ala Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Ser Val Ala Ser Glu Pro Glu Arg Gly Ala His Arg Ser Phe Pro Arg 
                245                 250                 255     


Ala Gln Gln Pro Pro Val Ser Glu Ala Pro Ala Val Thr Pro Ala Val 
            260                 265                 270         


Ala Ala Ser Pro Ala Ala Ser Trp Glu Gly Gly Pro Pro Gly Thr Arg 
        275                 280                 285             


Pro Thr Thr Pro Ala Trp His Pro Tyr Pro Gly Pro Gln Gly Val Pro 
    290                 295                 300                 


His Asp Pro Ala His Pro Glu Thr Lys Arg Phe Leu Tyr Cys Ser Gly 
305                 310                 315                 320 


Gly Arg Glu Arg Leu Arg Pro Ser Phe Leu Leu Ser Ala Leu Pro Pro 
                325                 330                 335     


Thr Leu Ser Gly Ala Arg Lys Leu Val Glu Thr Ile Phe Leu Gly Ser 
            340                 345                 350         


Ala Pro Gln Lys Pro Gly Ala Ala Arg Arg Met Arg Arg Leu Pro Ala 
        355                 360                 365             


Arg Tyr Trp Arg Met Arg Pro Leu Phe Gln Glu Leu Leu Gly Asn His 
    370                 375                 380                 


Ala Arg Cys Pro Tyr Arg Ala Leu Leu Arg Thr His Cys Pro Leu Arg 
385                 390                 395                 400 


Ala Met Ala Ala Lys Glu Gly Ser Gly Asn Gln Ala His Arg Gly Val 
                405                 410                 415     


Gly Ile Cys Pro Leu Glu Arg Pro Val Ala Ala Pro Gln Glu Gln Thr 
            420                 425                 430         


Asp Ser Thr Arg Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp 
        435                 440                 445             


Gln Val Tyr Ala Phe Leu Arg Ala Cys Leu Cys Trp Leu Val Pro Thr 
    450                 455                 460                 


Gly Leu Trp Gly Ser Arg His Asn Gln Arg Arg Phe Leu Arg Asn Val 
465                 470                 475                 480 


Lys Lys Phe Ile Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu 
                485                 490                 495     


Leu Thr Trp Lys Met Lys Val Arg Asp Cys Thr Trp Leu His Gly Asn 
            500                 505                 510         


Pro Gly Ala Cys Cys Val Pro Ala Ala Glu His Arg Arg Arg Glu Glu 
        515                 520                 525             


Ile Leu Ala Arg Phe Leu Val Leu Val Asp Gly His Ile Tyr Val Val 
    530                 535                 540                 


Lys Leu Leu Arg Ser Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys 
545                 550                 555                 560 


Asn Arg Leu Phe Phe Tyr Arg Lys Ser Val Trp Ser Gln Leu Gln Ser 
                565                 570                 575     


Ile Gly Ile Arg Gln Leu Phe Asn Ser Val His Leu Arg Glu Leu Ser 
            580                 585                 590         


Glu Ala Glu Val Arg Arg His Arg Glu Ala Arg Pro Ala Leu Leu Thr 
        595                 600                 605             


Ser Arg Leu Arg Phe Leu Pro Lys Pro Ser Gly Leu Arg Pro Ile Val 
    610                 615                 620                 


Asn Met Asp Tyr Ile Met Gly Ala Arg Thr Phe His Arg Asp Lys Lys 
625                 630                 635                 640 


Val Gln His Leu Thr Ser Gln Leu Lys Thr Leu Phe Ser Val Leu Asn 
                645                 650                 655     


Tyr Glu Arg Ala Arg Arg Pro Ser Leu Leu Gly Ala Ser Met Leu Gly 
            660                 665                 670         


Met Asp Asp Ile His Arg Ala Trp Arg Thr Phe Val Leu Arg Ile Arg 
        675                 680                 685             


Ala Gln Asn Pro Ala Pro Gln Leu Tyr Phe Val Lys Val Ala Ile Thr 
    690                 695                 700                 


Gly Ala Tyr Asp Thr Ile Pro Gln Asp Arg Leu Thr Glu Val Ile Ala 
705                 710                 715                 720 


Ser Ile Ile Lys Pro Gln Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val 
                725                 730                 735     


Val Gln Lys Ala Ala His Gly His Val Arg Lys Ala Phe Lys Ser His 
            740                 745                 750         


Val Ser Thr Leu Thr Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala 
        755                 760                 765             


His Leu Gln Glu Thr Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln 
    770                 775                 780                 


Ser Ser Ser Leu Asn Glu Ala Ser Ser Gly Leu Phe Asp Val Phe Leu 
785                 790                 795                 800 


Arg Phe Met Cys His His Ala Val Arg Ile Arg Gly Lys Ser Tyr Val 
                805                 810                 815     


Gln Cys Gln Gly Ile Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys 
            820                 825                 830         


Ser Leu Cys Tyr Gly Asp Met Glu Asn Lys Leu Phe Ala Gly Ile Arg 
        835                 840                 845             


Arg Asp Gly Leu Leu Leu Arg Leu Val Asp Asp Phe Leu Leu Val Thr 
    850                 855                 860                 


Pro His Leu Thr His Ala Lys Thr Phe Leu Arg Thr Leu Val Arg Gly 
865                 870                 875                 880 


Val Pro Glu Tyr Gly Cys Val Val Asn Leu Arg Lys Thr Val Val Asn 
                885                 890                 895     


Phe Pro Val Glu Asp Glu Ala Leu Gly Gly Thr Ala Phe Val Gln Met 
            900                 905                 910         


Pro Ala His Gly Leu Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg 
        915                 920                 925             


Thr Leu Glu Val Gln Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile 
    930                 935                 940                 


Arg Ala Ser Leu Thr Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met 
945                 950                 955                 960 


Arg Arg Lys Leu Phe Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe 
                965                 970                 975     


Leu Asp Leu Gln Val Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr 
            980                 985                 990         


Lys Ile Leu Leu Leu Gln Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln 
        995                 1000                 1005             


Leu Pro  Phe His Gln Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu 
    1010                 1015                 1020             


Arg Val  Ile Ser Asp Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys 
    1025                 1030                 1035             


Ala Lys  Asn Ala Gly Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly 
    1040                 1045                 1050             


Pro Leu  Pro Ser Glu Ala Val  Gln Trp Leu Cys His  Gln Ala Phe 
    1055                 1060                 1065             


Leu Leu  Lys Leu Thr Arg His  Arg Val Thr Tyr Val  Pro Leu Leu 
    1070                 1075                 1080             


Gly Ser  Leu Arg Thr Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro 
    1085                 1090                 1095             


Gly Thr  Thr Leu Thr Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu 
    1100                 1105                 1110             


Pro Ser  Asp Phe Lys Thr Ile  Leu Asp 
    1115                 1120         


<210>  3
<211>  1132
<212>  PRT
<213>  Artificial

<220>
<223>  chimeric fusion protein of human and dog telomerase

<400>  3

Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser His 
1               5                   10                  15      


Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly Pro 
            20                  25                  30          


Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg Ala 
        35                  40                  45              


Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro Pro 
    50                  55                  60                  


Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu Val 
65                  70                  75                  80  


Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val Leu 
                85                  90                  95      


Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro Glu 
            100                 105                 110         


Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr Asp 
        115                 120                 125             


Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val Gly 
    130                 135                 140                 


Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val Leu 
145                 150                 155                 160 


Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr Gln 
                165                 170                 175     


Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly Pro 
            180                 185                 190         


Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg Glu 
        195                 200                 205             


Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg Gly 
    210                 215                 220                 


Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg Gly 
225                 230                 235                 240 


Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp Ala 
                245                 250                 255     


His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val Val 
            260                 265                 270         


Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala Leu 
        275                 280                 285             


Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His Ala 
    290                 295                 300                 


Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro Cys 
305                 310                 315                 320 


Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly Asp 
                325                 330                 335     


Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro Ser 
            340                 345                 350         


Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser Arg 
        355                 360                 365             


Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln Arg 
    370                 375                 380                 


Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His Ala 
385                 390                 395                 400 


Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg Ala 
                405                 410                 415     


Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln Gly 
            420                 425                 430         


Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu Val 
        435                 440                 445             


Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe Val 
    450                 455                 460                 


Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser Arg 
465                 470                 475                 480 


His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser Leu 
                485                 490                 495     


Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met Ser 
            500                 505                 510         


Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys Val 
        515                 520                 525             


Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe Leu 
    530                 535                 540                 


His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe Phe 
545                 550                 555                 560 


Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr Arg 
                565                 570                 575     


Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His Leu 
            580                 585                 590         


Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln His 
        595                 600                 605             


Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro 
    610                 615                 620                 


Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val Gly 
625                 630                 635                 640 


Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser Arg 
                645                 650                 655     


Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro 
            660                 665                 670         


Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg Ala 
        675                 680                 685             


Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro Glu 
    690                 695                 700                 


Leu Tyr Phe Val Lys Val Ala Ile Thr Gly Ala Tyr Asp Ala Leu Pro 
705                 710                 715                 720 


Gln Asp Arg Leu Val Glu Val Ile Ala Asn Val Ile Arg Pro Gln Glu 
                725                 730                 735     


Ser Thr Tyr Cys Val Arg His Tyr Ala Val Val Gln Arg Thr Ala Arg 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Arg His Val Ser Thr Phe Ala Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Glu Arg Leu Gln Glu Thr Ser 
    770                 775                 780                 


Leu Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Gly Ser Ser Leu Phe His Leu Phe Leu Arg Leu Val His Asn His 
                805                 810                 815     


Val Val Arg Ile Gly Gly Lys Ser Tyr Ile Gln Cys Gln Gly Val Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Arg Arg Leu Phe Pro Gly Ile Glu Gln Asp Gly Val Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr Gln Ala 
865                 870                 875                 880 


Gln Ala Phe Leu Arg Thr Leu Val Lys Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Arg Ala Asn Leu Gln Lys Thr Ala Val Asn Phe Pro Val Glu Asp Gly 
            900                 905                 910         


Ala Leu Gly Ser Ala Ala Pro Leu Gln Leu Pro Ala His Cys Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Ser Cys 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala His Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Ser Gln Gly Ala Lys Pro Gly Arg Asn Met Arg Arg Lys Leu Leu Ala 
                965                 970                 975     


Val Leu Arg Leu Lys Cys Cys Ala Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Gly Ile His Thr Val Tyr Met Asn  Val Tyr Lys Ile Phe  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe Asn Gln 
    1010                 1015                 1020             


Pro Val  Arg Lys Asn Pro Ser  Phe Phe Leu Arg Val  Ile Ala Asp 
    1025                 1030                 1035             


Thr Ala  Ser Cys Cys Tyr Ser  Leu Leu Lys Ala Arg  Asn Ala Gly 
    1040                 1045                 1050             


Leu Ser  Leu Gly Ala Lys Gly  Ala Ser Gly Leu Phe  Pro Ser Glu 
    1055                 1060                 1065             


Ala Ala  Arg Trp Leu Cys Leu  His Ala Phe Leu Leu  Lys Leu Ala 
    1070                 1075                 1080             


His His  Ser Gly Thr Tyr Arg  Cys Leu Leu Gly Ala  Leu Gln Ala 
    1085                 1090                 1095             


Ala Lys  Ala His Leu Ser Arg  Gln Leu Pro Arg Gly  Thr Leu Ala 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asp  Pro Ser Leu Thr Ala  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  4
<211>  3471
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding SEQ ID NO:1

<400>  4
atgggatggt catgtattat tctgttcctg gtcgctaccg caaccggagt gcatagtcca       60

agagccccta gatgtcgagc cgtgagggca ctgctgcgca gccgataccg ggaggtgctg      120

cctctggcta ccttcctgcg gagactggga ccacagggat ggagactggt gaggcgaggg      180

gacccagcag cttttagggc tctggtcgca cagtgcctgg tgtgcgtgcc atggggagca      240

agaccacctc cagcagcccc ttcattcagg caggtgagct gcctgaaaga gctggtggct      300

agggtcctgc agcggctgtg cgaacgagga gcaaagaacg tgctggcttt cgggtttgca      360

ctgctggacg gagctagagg aggaccacct gtggccttca ccaccagcgt gcggagctat      420

ctgcccaata ccgtgacaga tactctgcga ggatccggag catggggact gctgctgcga      480

cgggtggggg acgatgtgct ggtccacctg ctggcacgat gcgctctgtt cctgctggtg      540

gccccttctt gcgcttacca ggtctgtgga ccacccctgt atcagctggg cgccccaaca      600

agtctgagac ctccaccccc tgcttcacca ccaagaaggc gcctgccagg actgagggca      660

tggaaccatg ccgtgcgcga cctgcgagtc actcgacagc tgcagaatag cggagcacga      720

cggagaaggg gatccccaag ctcctctctg ccactgccta agcgaccacg ccgatctgtg      780

gcaagtgagc ctgaacgaac cccagtcgga cgaggagctt ggagatcccc tccaagaaca      840

aggcagccat ctgtgagtgg cttcccagtg gtctctccag cagtcccagc aagccctgct      900

acctcctggg agggagcacc atccggaaca agaccatcta ctccagcatg gggaaggcag      960

caccatgctg gacccccttc aacaagcaga tacccaaggc catggggagt gcctcaccca     1020

ccagtccatc cagagactaa acggttcctg tatagttcag gaggcaagga acgcctgcga     1080

ccctcttttc tgctgagtgc actgcgacct tccctgtctg gagcacgaaa gctggtggag     1140

actatcttcc tgggaagccg cccttggatg ccaggaaccc cacggagact gaggcgcctg     1200

cctcagcggt actggcgaat gagaccactg tttcaggaac tgctgggaaa ccacgccagg     1260

tgcccatatc gcgtgctgct gaaaacacat tgtccactgc gggcaatggt gactcccgag     1320

gcctccgtca atcagagaca caagggagtg ggaatttgcc cacagggaag cgtggtcgca     1380

cctccacagg aacagacaga ctccactcgc ctggtgcagc tgctgcgaca gcatagctcc     1440

ccctggcagg tgtacgcttt tctgcgagca tgtctgcggt ggctggtgcc tacaggactg     1500

tggggaagcc gccacaacca gcgacggttc ctgcggaacg tgaagaagtt catctctctg     1560

ggcaagcatg ccaaactgag tctgcaggag ctgacctgga agatgtccgt gcgcgattgc     1620

acatggctga gaaggtctcc aggagtggga tgcgtgcctg ctgcagaaca ccgccgacgg     1680

gaggaaattc tggccaaatt cctggtgtgg ctgatgagtc atatctacgt ggtcaagctg     1740

ctgcggtcat tcttttatgt gaccgagact acctttcaga agaaccgact gttcttttat     1800

cggaaatcag tgtggagcca gctgcagtcc atcggcattc gccagctgct gaacagcgtg     1860

cagctgcgag agctgagtga ggcagaagtc agaaggcacc gcgaagcacg acctgccctg     1920

ctgacttcaa ggctgcgctt catccctaaa ccaagcggcc tgaggccaat tgtgaacatg     1980

gactacatca tgggggctcg caccttccgc cgagataaga aagtgcagag actgacctca     2040

aggctgaaga cactgtttag cgtgctgaat tatgagagag ctcggagacc tagtctgctg     2100

ggagcatcaa tgctgggcct ggacgatatt caccgggcat ggagaacctt cgtgctgcga     2160

atccgggcac agaacccacc tccacagctg tactttgtga aggtcgccat tactggcgct     2220

tatgacacca tcccccagga taggctggtg gaggtcatcg cctccatcat caagcctcag     2280

gaatctacat actgcgtgag gcgctatgct gtggtccaga agactgcacg cgggcacgtg     2340

cgaaaggctt tcaaatccca tgtctctacc ctgacagacc tgcagccata catgagacag     2400

tttgtggaga ggctgcagga aacaagcccc ctgcgcgatg cagtggtcat tgagcagtct     2460

agttcactga acgaagctag ctcctctctg ttccacctgt ttctgcggct gatgcacaat     2520

catgtggtca gaatcagggg caaatcttac atccagtgtc aggggattcc ccaaggaagt     2580

atcctgtcaa ccctgctgtg cagcctgtgc tatggggaca tggagcgcaa gctgttcccc     2640

gggatccgac gggatggact gctgctgcgg ctggtggacg atttcctgct ggtcacccct     2700

cacctgacac aggcccagac ttttctgaga accctggtga aaggcgtccc agagtacggg     2760

tgcgtggtca acctgaggaa gactgtggtc aatttccccg tggaagacgg ggctctggga     2820

tccaccgcac cactgcagct gcctgcacat ggactgtttc cttggtgtgg actgctgctg     2880

gacactagaa ccctggaggt gagttcagat tacagctcct atgcccggac ttcaattaga     2940

gctagcctga ccttctccag aggctttaag ccagggagga acatgagaag gaaactgctg     3000

gccgtgctga ggctgaagtg ccacgctctg tttctggacc tgcaggtgaa cagcatccag     3060

accgtctaca caaatatcta taaaattctg ctgctgcagg cctacagatt ccatgcttgc     3120

gtgctgcagc tgcccttcaa ccagcaggtc tggaagaatc cctccttctt tctgagagtg     3180

atcgctgata ccgcatctct gtgctatagt atcctgaagg ccaaaaatgc tggactgtct     3240

ctgggagcaa aaggagcagc tggaccactg cctagtgagg cagtgcggtg gctgtgcctg     3300

caggccttcc tgctgaagct gacaagacac agcgtgactt acgtcccact gctgggcgca     3360

ctgaggactg cccagaccca gctgtccagg cagctgcctc gcacaactct gacagccctg     3420

gaagcagccg ctaacccagc actgaccgcc gacttcaaaa caattctgga t              3471


<210>  5
<211>  3420
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding SEQ ID NO:2

<400>  5
atgggctggt cctgtattat tctgtttctg gtcgccaccg ctaccggagt ccatagtcct       60

agagcacccc gctgtcgcgc cgtgagggcc ctgctgagag gcaggtaccg cgaggtgctg      120

ccactggcta cctttctgcg gagactggga ccacctggca ggctgctggt gaggcgaggc      180

gaccctgcag ctttccgcgc cctggtggct cagtgcctgg tgtgcgtgcc ttggggagca      240

aggccaccac ctgcagcacc atgctttcga caggtgagct gtctgaagga gctggtcgca      300

cgagtggtcc agcgactgtg cgaaaggggc gctcgcaacg tgctggcatt cggctttgcc      360

ctgctggatg gagctcgagg aggaccacca gtggccttca ccaccagcgt gcggagctac      420

ctgcccaata ctgtgaccga gacactgagg ggatccggag catggggact gctgctgcga      480

cgagtggggg acgatgtcct gacacacctg ctggcacgct gcgccctgta tctgctggtg      540

gctccctcat gcgcatacca ggtctgtggc cctccactgt atgacctgtg cgcacctgcc      600

agcctgcccc tgcctgcccc agggctgcct ggactgccag gactgccagg actgggagct      660

ggagcagggg cctcagctga tctgcgacct acccggcagg ctcagaacag cggagcaaga      720

aggcgccgag gaagtccagg atcaggagtg cctctggcaa agaggccacg gagaagcgtc      780

gcatccgagc cagaacgagg agctcaccgg agcttcccta gggcacagca gccacctgtg      840

agtgaggcac ctgcagtgac tccagcagtc gctgcaagtc ctgcagcttc atgggaagga      900

ggaccaccag gaacccgacc tactacccca gcttggcatc cataccctgg accacaggga      960

gtgccacacg accctgccca tccagagacc aagcggtttc tgtattgcag cgggggacga     1020

gaacggctga gaccaagctt cctgctgtcc gccctgcctc caacactgag tggggctaga     1080

aaactggtgg agactatctt tctgggatca gctccacaga agcctggagc agcaaggcga     1140

atgcgacggc tgcctgccag gtactggagg atgcgcccac tgttccagga gctgctggga     1200

aaccacgctc gatgccccta tcgagcactg ctgcggacac attgtcctct gcgggcaatg     1260

gctgcaaagg aagggagtgg aaatcaggca caccgaggag tgggaatctg ccccctggag     1320

agacctgtcg cagctccaca ggaacagacc gacagcacac gactggtgca gctgctgcgc     1380

cagcatagct ccccatggca ggtgtacgcc tttctgagag cttgcctgtg ctggctggtg     1440

ccaaccggac tgtgggggtc caggcacaac cagagaaggt ttctgcgcaa tgtgaagaaa     1500

ttcatctccc tgggcaagca tgccaaactg tctctgcagg agctgacctg gaagatgaaa     1560

gtgagggact gtacatggct gcacggaaac ccaggagctt gctgcgtgcc tgcagcagaa     1620

catcgccgac gggaggaaat cctggccaga tttctggtgc tggtcgatgg acacatctac     1680

gtggtcaaac tgctgaggtc tttcttttat gtgaccgaga caactttcca gaagaatagg     1740

ctgttctttt atcgcaagag cgtgtggagt aaactgcagt ctatcggcat tagacagcac     1800

ctgaaaagag tgcagctgag ggagctgagt gaggccgaag tcagacagca tagggaagct     1860

cgccctgcac tgctgacaag ccgactgcgg ttcatcccca agcctgacgg gctgcgccca     1920

attgtgaaca tggattacgt ggtcggagca cggaccttta gaagggagaa acgagccgaa     1980

cggctgacat caagagtgaa ggctctgttc agcgtcctga attatgagag ggcacgccga     2040

cccggactgc tgggagcctc tgtgctgggg ctggacgaca tccacagagc ttggaggacc     2100

tttgtgctga gagtcagggc acaggacccc cctccagagc tgtacttcgt gaaggtcgca     2160

atcaccggag cctatgacac aattccacag gatcgcctga ctgaagtgat tgccagcatc     2220

atcaagcccc agaataccta ctgcgtgcgg agatatgcag tggtccagaa ggctgcacac     2280

ggccatgtgc ggaaggcctt taaatcacac gtcagcactc tgaccgatct gcagccttac     2340

atgcgccagt tcgtggctca tctgcaggag acttctccac tgcgggacgc agtggtcatc     2400

gagcagtcta gttcactgaa cgaagctagc tccgggctgt tcgacgtgtt cctgaggttc     2460

atgtgccacc atgccgtgcg cattcgagga aaatcctacg tccagtgtca gggaatccca     2520

cagggctcca ttctgtctac cctgctgtgc tctctgtgct atggcgacat ggagaataag     2580

ctgtttgcag gcatcaggcg agatggactg ctgctgagac tggtggacga ttttctgctg     2640

gtcacccccc acctgacaca tgccaaaact ttcctgcgca ccctggtgcg aggagtccct     2700

gaatacggct gcgtggtcaa cctgaggaag acagtggtca atttcccagt ggaggacgaa     2760

gccctgggag gaactgcttt tgtccagatg ccagcacacg gactgttccc atggtgtgga     2820

ctgctgctgg acacacgcac tctggaggtg cagagcgatt actctagtta tgcccggaca     2880

tctatcagag ctagtctgac ttttaaccgg gggttcaagg ccggaagaaa tatgcgacgg     2940

aaactgtttg gcgtgctgcg gctgaagtgc catagtctgt tcctggacct gcaggtgaac     3000

tcactgcaga ctgtctgtac caatatctac aaaattctgc tgctgcaggc atatagattt     3060

cacgcctgcg tgctgcagct gccattccat cagcaggtct ggaagaaccc cactttcttt     3120

ctgagagtga tcagcgatac cgctagcctg tgctactcca ttctgaaggc caaaaatgct     3180

ggaatgtccc tgggagcaaa aggagcagct ggaccactgc catctgaggc tgtgcagtgg     3240

ctgtgccacc aggcattcct gctgaagctg actcggcata gagtgaccta tgtcccactg     3300

ctgggaagcc tgcggacagc ccagactcag ctgtccagaa agctgccagg aaccacactg     3360

accgccctgg aagcagccgc taacccagct ctgcccagcg actttaaaac aatcctggat     3420


<210>  6
<211>  3453
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding SEQ ID NO:3

<400>  6
atgggatggt cttgtattat tctgttcctg gtcgccactg ccaccggggt ccacagccct       60

agagcaccta gatgtagagc cgtgagaagt ctgctgcgct cacactaccg agaggtgctg      120

cctctggcca cattcgtccg gagactggga ccacagggat ggcgactggt gcagagaggc      180

gatccagcag cttttagagc tctggtcgca cagtgcctgg tgtgcgtgcc atgggacgca      240

cgaccacctc cagcagcccc tagcttccgg caggtgtcct gcctgaaaga actggtggca      300

agggtcctgc agcggctgtg cgagcgagga gctaagaacg tgctggcatt cggatttgca      360

ctgctggatg gagcacgagg aggaccacct gaggccttta ccacaagcgt gcggtcctat      420

ctgcccaata cagtcactga cgctctgaga ggcagcggag catggggact gctgctgagg      480

cgagtgggcg acgatgtgct ggtccacctg ctggcacgat gcgctctgtt cgtgctggtc      540

gctccttcct gcgcatacca ggtgtgcgga ccaccactgt atcagctggg agctgcaacc      600

caggcaagac ctccaccaca cgctagtgga cctcgacgga gactgggatg tgaaagggct      660

tggaaccatt cagtgcgcga ggcaggagtc ccactgggac tgccagcacc tggagcaagg      720

cgccgaggag gaagtgcctc acgaagcctg ccactgccaa agcgaccacg aagaggagca      780

gctcctgaac cagagaggac tcccgtggga cagggatcct gggcacaccc aggaaggacc      840

cgcggaccct cagatagagg cttctgcgtg gtcagccctg ctaggccagc agaggaagcc      900

actagtctgg agggcgccct gtcagggacc agacactctc atcccagtgt gggcaggcag      960

caccatgctg ggcctccatc cacatctcgg ccccctagac catgggatac tccctgtcca     1020

cccgtgtacg ccgaaaccaa acatttcctg tatagctccg gcgacaagga gcagctgcgc     1080

ccaagttttc tgctgtctag tctgcgacca tcactgaccg gagcaaggcg cctggtggaa     1140

acaatcttcc tgggaagcag gccctggatg cctggaactc cacgacggct gccacgactg     1200

cctcagagat actggcagat gcgccctctg tttctggagc tgctgggaaa ccacgcacag     1260

tgcccatatg gagtgctgct gaaaacacat tgtcccctga gggcagcagt gactcctgct     1320

gcaggcgtct gcgcacgaga gaagccacag ggaagcgtgg cagctccaga ggaagaggac     1380

accgatccta gaaggctggt gcagctgctg aggcagcact caagcccttg gcaggtgtac     1440

ggattcgtcc gcgcatgtct gcgccgactg gtgcctccag gactgtgggg aagccgccac     1500

aacgaacgga gattcctgcg aaataccaag aagttcatct ccctggggaa gcatgccaaa     1560

ctgtctctgc aggagctgac atggaaaatg tcagtgaggg actgcgcttg gctgaggcgc     1620

agccctggag tgggatgcgt gccagcagca gagcaccgac tgcgagaaga gattctggcc     1680

aagttcctgc attggctgat gagcgtgtac gtggtcgaac tgctgcgctc cttcttttat     1740

gtcaccgaga ctacctttca gaagaacaga ctgttctttt ataggaaatc agtgtggagc     1800

cagctgcaga gcatcggcat tagacagctg ttcaatagcg tgcacctgag ggaactgtcc     1860

gaagcagagg tccgacggca tagggaggct cgaccagcac tgctgaccag ccggctgagg     1920

tttctgccca aacctagtgg actgaggccc atcgtgaaca tggattacat tatgggcgcc     1980

aggactttcc accgcgacaa gaaagtgcag catctgacct ctcagctgaa gacactgttt     2040

agtgtgctga attatgagcg agcaagaagg ccctctctgc tgggagctag tatgctgggg     2100

atggacgaca tccaccgagc atggcggacc ttcgtgctgc gcattcgagc ccagaaccca     2160

gctccccagc tgtactttgt gaaggtcgcc atcacaggag cctatgacgc tctgccacag     2220

gataggctgg tggaagtcat cgccaatgtg attcgaccac aggagtccac ctactgcgtc     2280

cggcattatg cagtggtcca gagaacagcc aggggccacg tgcgcaaggc tttcaaacga     2340

cacgtgagca ccttcgccga cctgcagcca tacatgcggc agtttgtgga aagactgcag     2400

gagaccagcc tgctgcgaga cgcagtggtc attgaacagt cctctagtct gaacgaggct     2460

ggctcaagcc tgttccacct gtttctgcgc ctggtgcaca atcatgtggt ccggatcggg     2520

ggaaagagtt acattcagtg tcagggagtg ccccagggct ccatcctgtc taccctgctg     2580

tgctccctgt gctatggcga tatggaacgc cgactgttcc ccggaattga gcaggacggc     2640

gtgctgctgc gactggtgga cgatttcctg ctggtgactc ctcatctgac ccaggcccag     2700

gcttttctgc ggacactggt gaaaggggtc cccgaatacg gatgcagagc taacctgcag     2760

aagactgcag tgaatttccc tgtcgaggac ggggccctgg gatctgctgc acctctgcag     2820

ctgccagctc actgcctgtt tccatggtgt ggcctgctgc tggatacccg gacactggag     2880

gtgagctgtg actactcctc ttatgcccat acaagcatca gagcttccct gactttctct     2940

cagggggcca agcccggaag aaacatgcgg agaaaactgc tggcagtgct gaggctgaag     3000

tgctgtgccc tgtttctgga tctgcaggtg aacggcatcc acaccgtgta catgaatgtc     3060

tataaaattt tcctgctgca ggcataccgg tttcatgcct gcgtgctgca gctgcccttc     3120

aaccagcctg tcagaaagaa tcctagcttc tttctgagag tgatcgcaga cacagccagt     3180

tgctgttatt cactgctgaa agctagaaat gcaggactgt ccctgggagc aaagggagct     3240

tcaggactgt tcccaagcga agccgctagg tggctgtgcc tgcacgcatt tctgctgaaa     3300

ctggcccacc atagcggaac ttaccgatgt ctgctgggcg ctctgcaggc agccaaggca     3360

catctgtccc gacagctgcc acgagggacc ctggctgcac tggaggcagc tgcagaccct     3420

tctctgactg ccgatttcaa aaccatcctg gac                                  3453


<210>  7
<211>  3399
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding SEQ ID NO:29

<400>  7
atgccgcgcg ctccccgctg ccgagccgtg cgctccctgc tgcgcagcca ctaccgcgag       60

gtgctgccgc tggccacgtt cgtgcggcgc ctggggcccc agggctggcg gctggtgcag      120

cgcggggacc cggcggcttt ccgcgcgctg gtggcccagt gcctggtgtg cgtgccctgg      180

gacgcacggc cgccccccgc cgccccctcc ttccgccagg tgtcctgcct gaaggagctg      240

gtggcccgag tgctgcagag gctgtgcgag cgcggcgcga agaacgtgct ggccttcggc      300

ttcgcgctgc tggacggggc ccgcgggggc ccccccgagg ccttcaccac cagcgtgcgc      360

agctacctgc ccaacacggt gaccgacgca ctgcggggga gcggggcgtg ggggctgctg      420

ctgcgccgcg tgggcgacga cgtgctggtt cacctgctgg cacgctgcgc gctctttgtg      480

ctggtggctc ccagctgcgc ctaccaggtg tgcgggccgc cgctgtacca gctcggcgct      540

gccactcagg cccggccccc gccacacgct agtggacccc gaaggcgtct gggatgcgaa      600

cgggcctgga accatagcgt cagggaggcc ggggtccccc tgggcctgcc agccccgggt      660

gcgaggaggc gcgggggcag tgccagccga agtctgccgt tgcccaagag gcccaggcgt      720

ggcgctgccc ctgagccgga gcggacgccc gttgggcagg ggtcctgggc ccacccgggc      780

aggacgcgtg gaccgagtga ccgtggtttc tgtgtggtgt cacctgccag acccgccgaa      840

gaagccacct ctttggaggg tgcgctctct ggcacgcgcc actcccaccc atccgtgggc      900

cgccagcacc acgcgggccc cccatccaca tcgcggccac cacgtccctg ggacacgcct      960

tgtcccccgg tgtacgccga gaccaagcac ttcctctact cctcaggcga caaggagcag     1020

ctgcggccct ccttcctact cagctctctg aggcccagcc tgactggcgc tcggaggctc     1080

gtggagacca tctttctggg ttccaggccc tggatgccag ggactccccg caggttgccc     1140

cgcctgcccc agcgctactg gcaaatgcgg cccctgtttc tggagctgct tgggaaccac     1200

gcgcagtgcc cctacggggt gctcctcaag acgcactgcc cgctgcgagc tgcggtcacc     1260

ccagcagccg gtgtctgtgc ccgggagaag ccccagggct ctgtggcggc ccccgaggag     1320

gaggacacag acccccgtcg cctggtgcag ctgctccgcc agcacagcag cccctggcag     1380

gtgtacggct tcgtgcgggc ctgcctgcgc cggctggtgc ccccaggcct ctggggctcc     1440

aggcacaacg aacgccgctt cctcaggaac accaagaagt tcatctccct ggggaagcat     1500

gccaagctct cgctgcagga gctgacgtgg aagatgagcg tgcgggactg cgcttggctg     1560

cgcaggagcc caggggttgg ctgtgttccg gccgcagagc accgtctgcg tgaggagatc     1620

ctggccaagt tcctgcactg gctgatgagt gtgtacgtcg tcgagctgct caggtctttc     1680

ttttatgtca cggagaccac gtttcaaaag aacaggctct ttttctaccg gaagagtgtc     1740

tggagcaagt tgcaaagcat tggaatcaga cagcacttga agagggtgca gctgcgggag     1800

ctgtcggaag cagaggtcag gcagcatcgg gaagccaggc ccgccctgct gacgtccaga     1860

ctccgcttca tccccaagcc tgacgggctg cggccgattg tgaacatgga ctacgtcgtg     1920

ggagccagaa cgttccgcag agaaaagagg gccgagcgtc tcacctcgag ggtgaaggca     1980

ctgttcagcg tgctcaacta cgagcgggcg cggcgccccg gcctcctggg cgcctctgtg     2040

ctgggcctgg acgatatcca cagggcctgg cgcaccttcg tgctgcgtgt gcgggcccag     2100

gacccgccgc ctgagctgta ctttgtcaag gtggatgtga cgggcgcgta cgacaccatc     2160

ccccaggaca ggctcacgga ggtcatcgcc agcatcatca aaccccagaa cacgtactgc     2220

gtgcgtcggt atgccgtggt ccagaaggcc gcccatgggc acgtccgcaa ggccttcaag     2280

agccacgtct ctaccttgac agacctccag ccgtacatgc gacagttcgt ggctcacctg     2340

caggagacca gcccgctgag ggatgccgtc gtcatcgagc agagctcctc cctgaatgag     2400

gccagcagtg gcctcttcga cgtcttccta cgcttcatgt gccaccacgc cgtgcgcatc     2460

aggggcaagt cctacgtcca gtgccagggg atcccgcagg gctccatcct ctccacgctg     2520

ctctgcagcc tgtgctacgg cgacatggag aacaagctgt ttgcggggat tcggcgggac     2580

gggctgctcc tgcgtttggt ggatgatttc ttgttggtga cacctcacct cacccacgcg     2640

aaaaccttcc tcaggaccct ggtccgaggt gtccctgagt atggctgcgt ggtgaacttg     2700

cggaagacag tggtgaactt ccctgtagaa gacgaggccc tgggtggcac ggcttttgtt     2760

cagatgccgg cccacggcct attcccctgg tgcggcctgc tgctggatac ccggaccctg     2820

gaggtgcaga gcgactactc cagctatgcc cggacctcca tcagagccag tctcaccttc     2880

aaccgcggct tcaaggctgg gaggaacatg cgtcgcaaac tctttggggt cttgcggctg     2940

aagtgtcaca gcctgtttct ggatttgcag gtgaacagcc tccagacggt gtgcaccaac     3000

atctacaaga tcctcctgct gcaggcgtac aggtttcacg catgtgtgct gcagctccca     3060

tttcatcagc aagtttggaa gaaccccaca tttttcctgc gcgtcatctc tgacacggcc     3120

tccctctgct actccatcct gaaagccaag aacgcaggga tgtcgctggg ggccaagggc     3180

gccgccggcc ctctgccctc cgaggccgtg cagtggctgt gccaccaagc attcctgctc     3240

aagctgactc gacaccgtgt cacctacgtg ccactcctgg ggtcactcag gacagcccag     3300

acgcagctga gtcggaagct cccggggacg acgctgactg ccctggaggc cgcagccaac     3360

ccggcactgc cctcagactt caagaccatc ctggactga                            3399


<210>  8
<211>  3441
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding SEQ ID NO:30

<400>  8
atggacgcca tgaagagggg cctgtgctgc gtgctgctgc tgtgcggagc cgtgttcgtg       60

agccccagcg agatccccag agcccccaga tgtagggccg tgagggccct gctgaggggc      120

agatacagag aggtgctgcc cctggccacc ttcctgagaa ggctgggccc tcctggcaga      180

ctgctggtcc gcagaggcga tcctgccgcc tttagagccc tggtggccca gtgcctggtc      240

tgtgtgcctt ggggagccag acctcctcct gccgcccctt gcttcaggca ggtgtcctgc      300

ctgaaagaac tggtggccag ggtggtgcag agactgtgcg agaggggcgc cagaaacgtg      360

ctggccttcg gctttgccct gctggatggc gctagaggcg gccctcctgt ggccttcacc      420

acctccgtgc ggagctacct gcccaacacc gtgaccgaga ccctgagagg aagcggagcc      480

tggggcctgc tgctgagaag agtgggcgac gacgtgctga cccacctgct ggccagatgc      540

gccctgtacc tgctggtcgc ccctagctgt gcctaccagg tctgcggccc tcccctgtat      600

gacctgtgcg cccctgcctc tctgcctctg cctgcccctg gactgcctgg cctgccaggg      660

ctgcctggac tgggagctgg cgctggcgcc tctgccgacc tgagacccac cagacaggcc      720

cagaacagcg gcgccagaag aagaagaggc agccccggaa gcggcgtgcc tctggccaag      780

aggcctcgga gaagcgtggc ctctgagccc gaaagaggcg cccacagaag cttccccaga      840

gcccagcagc ctcctgtgtc tgaggcccct gccgtgacac ctgccgtggc cgcctctcct      900

gctgcttctt gggagggcgg acctcctgga accagaccca ccacccccgc ctggcaccct      960

tatcctggcc ctcagggcgt gcctcacgat cctgcccacc ccgagaccaa gcggttcctg     1020

tactgcagcg gcggcagaga gaggctgagg cccagcttcc tgctgtctgc cctgcctcct     1080

accctgagcg gagcccggaa actggtggag accatcttcc tgggcagcgc tcctcagaag     1140

cctggcgccg ctcggagaat gcggaggctg cccgccagat actggcggat gcggcccctg     1200

ttccaggaac tgctgggcaa ccacgccaga tgcccctaca gggccctgct gaggacccac     1260

tgccctctga gggccatggc cgccaaagag ggcagcggca accaggccca cagaggcgtg     1320

ggcatctgcc ccctggaaag acccgtggcc gctccccagg aacagaccga cagcaccagg     1380

ctggtgcagc tgctgagaca gcacagcagc ccctggcagg tgtacgcctt cctgagggcc     1440

tgcctgtgtt ggctggtgcc taccggcctg tggggcagca ggcacaacca gaggcggttt     1500

ctgaggaacg tgaagaagtt catcagcctg ggcaagcacg ccaagctgtc cctgcaggaa     1560

ctgacctgga agatgaaagt gcgggactgc acctggctgc acggcaatcc tggcgcctgt     1620

tgtgtgcctg ccgccgagca caggcggagg gaagagatcc tggcccggtt cctggtgctg     1680

gtcgatggcc acatctacgt ggtgaagctg ctgcggagct tcttctacgt gaccgagacc     1740

accttccaga aaaataggct gttcttctac cggaagagcg tgtggagcca gctgcagagc     1800

atcggcatca ggcagctgtt caacagcgtg cacctgagag agctgtccga ggccgaagtg     1860

aggcggcaca gagaggccag acccgccctg ctgaccagca ggctgagatt cctgcccaag     1920

cccagcggcc tgaggcccat cgtgaacatg gactacatca tgggcgccag gaccttccac     1980

agggacaaga aggtgcagca cctgaccagc cagctgaaaa ccctgttcag cgtgctgaac     2040

tacgagaggg ccagaaggcc tagcctgctg ggcgccagca tgctgggcat ggacgacatc     2100

cacagggcct ggcggacctt cgtgctgagg atcagggccc agaaccctgc cccccagctg     2160

tacttcgtga aggtggccat caccggcgcc tacgacgccc tgcctcagga cagactggtg     2220

gaggtgatcg ccaacgtgat caggccccag gaaagcacct actgcgtcag gcactacgcc     2280

gtggtgcaga gaaccgccag gggccacgtg aggaaggcct tcaagaggca cgtgagcacc     2340

ttcgccgacc tgcagcccta catgaggcag ttcgtggaga ggctgcagga gaccagcctg     2400

ctgagggatg ccgtggtgat cgagcagagc agcagcctga acgaggccgg cagctccctg     2460

ttccacctgt ttctgaggct ggtgcacaac cacgtggtgc ggatcggcgg caagagctac     2520

atccagtgcc agggcgtgcc tcagggcagc atcctgagca ccctgctgtg cagcctgtgc     2580

tacggcgaca tggaaaggcg gctgttccct ggcatcgagc aggacggcgt gctgctgaga     2640

ctggtggacg acttcctgct ggtgacccct catctgaccc aggcccaggc cttcctgaga     2700

accctggtga agggcgtgcc cgagtacggc tgcagggcca acctgcagaa aaccgccgtg     2760

aacttccctg tggaggacgg cgctctggga tctgctgccc ctctgcagct gcctgcccac     2820

tgcctgttcc cttggtgcgg cctgctgctg gacaccagga ccctggaagt gagctgcgac     2880

tacagcagct acgcccacac cagcatcagg gccagcctga ccttcagcca gggcgccaag     2940

cccggcagga acatgcggag gaagctgctg gccgtgctga ggctgaagtg ctgcgccctg     3000

ttcctggacc tgcaggtcaa cggcatccac accgtgtaca tgaacgtgta caaaatcttc     3060

ctgctgcagg cctacaggtt ccacgcctgc gtgctgcagc tgcccttcaa ccagcccgtg     3120

aggaagaacc ccagcttctt cctgagggtg atcgccgaca ccgccagctg ctgctacagc     3180

ctgctgaagg ccagaaatgc cggcctgtct ctgggagcca agggcgccag cggcctgttt     3240

cctagcgagg ccgccagatg gctgtgcctg cacgcctttc tgctgaagct ggcccaccac     3300

agcggcacct acagatgcct gctgggagcc ctgcaggccg ccaaagccca cctgagcagg     3360

cagctgccta gaggaacact ggccgccctg gaagccgccg ctgaccctag cctgaccgcc     3420

gacttcaaga ccatcctgga c                                               3441


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Pro Arg Cys Arg Ala Val Arg Ser 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  10

Ala Pro Arg Cys Arg Ala Val Arg Ala 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Val Leu Pro Leu Ala Thr Phe Val 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  12

Glu Val Leu Pro Leu Ala Thr Phe Leu 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Val Glu Leu Leu Arg Ser Phe Phe Tyr 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  14

Val Lys Leu Leu Arg Ser Phe Phe Tyr 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Leu Thr Ser Arg Leu Arg Phe Ile 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  16

Leu Leu Thr Ser Arg Leu Arg Phe Leu 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Pro Ile Val Asn Met Asp Tyr Val 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  18

Arg Pro Ile Val Asn Met Asp Tyr Ile 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Lys Ala Leu Phe Ser Val Leu Asn Tyr 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  20

Lys Thr Leu Phe Ser Val Leu Asn Tyr 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Leu Asp Asp Ile His Arg Ala Trp 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  22

Gly Met Asp Asp Ile His Arg Ala Trp 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Trp Arg Thr Phe Val Leu Arg Val 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  24

Ala Trp Arg Thr Phe Val Leu Arg Ile 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Pro Leu Arg Asp Ala Val Val Ile 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  26

Ser Leu Leu Arg Asp Ala Val Val Ile 
1               5                   


<210>  27
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding SEQ ID NO:28

<400>  27
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcgcccagc                                                               69


<210>  28
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tissue Plasminogen Activator (TPA)

<400>  28

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser 
            20              


<210>  29
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  30
<211>  1125
<212>  PRT
<213>  Canis familiaris

<400>  30

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ala Leu Leu Arg Gly 
1               5                   10                  15      


Arg Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Leu Arg Arg Leu Gly 
            20                  25                  30          


Pro Pro Gly Arg Leu Leu Val Arg Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Gly Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Cys Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Val Gln Arg Leu Cys Glu Arg Gly Ala Arg Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Val Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Glu Thr Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Thr His Leu Leu Ala Arg Cys Ala Leu Tyr Leu 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Asp Leu Cys Ala Pro Ala Ser Leu Pro Leu Pro Ala Pro Gly Leu Pro 
            180                 185                 190         


Gly Leu Pro Gly Leu Pro Gly Leu Gly Ala Gly Ala Gly Ala Ser Ala 
        195                 200                 205             


Asp Leu Arg Pro Thr Arg Gln Ala Gln Asn Ser Gly Ala Arg Arg Arg 
    210                 215                 220                 


Arg Gly Ser Pro Gly Ser Gly Val Pro Leu Ala Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Ser Val Ala Ser Glu Pro Glu Arg Gly Ala His Arg Ser Phe Pro Arg 
                245                 250                 255     


Ala Gln Gln Pro Pro Val Ser Glu Ala Pro Ala Val Thr Pro Ala Val 
            260                 265                 270         


Ala Ala Ser Pro Ala Ala Ser Trp Glu Gly Gly Pro Pro Gly Thr Arg 
        275                 280                 285             


Pro Thr Thr Pro Ala Trp His Pro Tyr Pro Gly Pro Gln Gly Val Pro 
    290                 295                 300                 


His Asp Pro Ala His Pro Glu Thr Lys Arg Phe Leu Tyr Cys Ser Gly 
305                 310                 315                 320 


Gly Arg Glu Arg Leu Arg Pro Ser Phe Leu Leu Ser Ala Leu Pro Pro 
                325                 330                 335     


Thr Leu Ser Gly Ala Arg Lys Leu Val Glu Thr Ile Phe Leu Gly Ser 
            340                 345                 350         


Ala Pro Gln Lys Pro Gly Ala Ala Arg Arg Met Arg Arg Leu Pro Ala 
        355                 360                 365             


Arg Tyr Trp Arg Met Arg Pro Leu Phe Gln Glu Leu Leu Gly Asn His 
    370                 375                 380                 


Ala Arg Cys Pro Tyr Arg Ala Leu Leu Arg Thr His Cys Pro Leu Arg 
385                 390                 395                 400 


Ala Met Ala Ala Lys Glu Gly Ser Gly Asn Gln Ala His Arg Gly Val 
                405                 410                 415     


Gly Ile Cys Pro Leu Glu Arg Pro Val Ala Ala Pro Gln Glu Gln Thr 
            420                 425                 430         


Asp Ser Thr Arg Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp 
        435                 440                 445             


Gln Val Tyr Ala Phe Leu Arg Ala Cys Leu Cys Trp Leu Val Pro Thr 
    450                 455                 460                 


Gly Leu Trp Gly Ser Arg His Asn Gln Arg Arg Phe Leu Arg Asn Val 
465                 470                 475                 480 


Lys Lys Phe Ile Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu 
                485                 490                 495     


Leu Thr Trp Lys Met Lys Val Arg Asp Cys Thr Trp Leu His Gly Asn 
            500                 505                 510         


Pro Gly Ala Cys Cys Val Pro Ala Ala Glu His Arg Arg Arg Glu Glu 
        515                 520                 525             


Ile Leu Ala Arg Phe Leu Val Leu Val Asp Gly His Ile Tyr Val Val 
    530                 535                 540                 


Lys Leu Leu Arg Ser Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys 
545                 550                 555                 560 


Asn Arg Leu Phe Phe Tyr Arg Lys Ser Val Trp Ser Gln Leu Gln Ser 
                565                 570                 575     


Ile Gly Ile Arg Gln Leu Phe Asn Ser Val His Leu Arg Glu Leu Ser 
            580                 585                 590         


Glu Ala Glu Val Arg Arg His Arg Glu Ala Arg Pro Ala Leu Leu Thr 
        595                 600                 605             


Ser Arg Leu Arg Phe Leu Pro Lys Pro Ser Gly Leu Arg Pro Ile Val 
    610                 615                 620                 


Asn Met Asp Tyr Ile Met Gly Ala Arg Thr Phe His Arg Asp Lys Lys 
625                 630                 635                 640 


Val Gln His Leu Thr Ser Gln Leu Lys Thr Leu Phe Ser Val Leu Asn 
                645                 650                 655     


Tyr Glu Arg Ala Arg Arg Pro Ser Leu Leu Gly Ala Ser Met Leu Gly 
            660                 665                 670         


Met Asp Asp Ile His Arg Ala Trp Arg Thr Phe Val Leu Arg Ile Arg 
        675                 680                 685             


Ala Gln Asn Pro Ala Pro Gln Leu Tyr Phe Val Lys Val Ala Ile Thr 
    690                 695                 700                 


Gly Ala Tyr Asp Ala Leu Pro Gln Asp Arg Leu Val Glu Val Ile Ala 
705                 710                 715                 720 


Asn Val Ile Arg Pro Gln Glu Ser Thr Tyr Cys Val Arg His Tyr Ala 
                725                 730                 735     


Val Val Gln Arg Thr Ala Arg Gly His Val Arg Lys Ala Phe Lys Arg 
            740                 745                 750         


His Val Ser Thr Phe Ala Asp Leu Gln Pro Tyr Met Arg Gln Phe Val 
        755                 760                 765             


Glu Arg Leu Gln Glu Thr Ser Leu Leu Arg Asp Ala Val Val Ile Glu 
    770                 775                 780                 


Gln Ser Ser Ser Leu Asn Glu Ala Gly Ser Ser Leu Phe His Leu Phe 
785                 790                 795                 800 


Leu Arg Leu Val His Asn His Val Val Arg Ile Gly Gly Lys Ser Tyr 
                805                 810                 815     


Ile Gln Cys Gln Gly Val Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu 
            820                 825                 830         


Cys Ser Leu Cys Tyr Gly Asp Met Glu Arg Arg Leu Phe Pro Gly Ile 
        835                 840                 845             


Glu Gln Asp Gly Val Leu Leu Arg Leu Val Asp Asp Phe Leu Leu Val 
    850                 855                 860                 


Thr Pro His Leu Thr Gln Ala Gln Ala Phe Leu Arg Thr Leu Val Lys 
865                 870                 875                 880 


Gly Val Pro Glu Tyr Gly Cys Arg Ala Asn Leu Gln Lys Thr Ala Val 
                885                 890                 895     


Asn Phe Pro Val Glu Asp Gly Ala Leu Gly Ser Ala Ala Pro Leu Gln 
            900                 905                 910         


Leu Pro Ala His Cys Leu Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr 
        915                 920                 925             


Arg Thr Leu Glu Val Ser Cys Asp Tyr Ser Ser Tyr Ala His Thr Ser 
    930                 935                 940                 


Ile Arg Ala Ser Leu Thr Phe Ser Gln Gly Ala Lys Pro Gly Arg Asn 
945                 950                 955                 960 


Met Arg Arg Lys Leu Leu Ala Val Leu Arg Leu Lys Cys Cys Ala Leu 
                965                 970                 975     


Phe Leu Asp Leu Gln Val Asn Gly Ile His Thr Val Tyr Met Asn Val 
            980                 985                 990         


Tyr Lys Ile Phe Leu Leu Gln Ala  Tyr Arg Phe His Ala  Cys Val Leu 
        995                 1000                 1005             


Gln Leu  Pro Phe Asn Gln Pro  Val Arg Lys Asn Pro  Ser Phe Phe 
    1010                 1015                 1020             


Leu Arg  Val Ile Ala Asp Thr  Ala Ser Cys Cys Tyr  Ser Leu Leu 
    1025                 1030                 1035             


Lys Ala  Arg Asn Ala Gly Leu  Ser Leu Gly Ala Lys  Gly Ala Ser 
    1040                 1045                 1050             


Gly Leu  Phe Pro Ser Glu Ala  Ala Arg Trp Leu Cys  Leu His Ala 
    1055                 1060                 1065             


Phe Leu  Leu Lys Leu Ala His  His Ser Gly Thr Tyr  Arg Cys Leu 
    1070                 1075                 1080             


Leu Gly  Ala Leu Gln Ala Ala  Lys Ala His Leu Ser  Arg Gln Leu 
    1085                 1090                 1095             


Pro Arg  Gly Thr Leu Ala Ala  Leu Glu Ala Ala Ala  Asp Pro Ser 
    1100                 1105                 1110             


Leu Thr  Ala Asp Phe Lys Thr  Ile Leu Asp Ser Arg  
    1115                 1120                 1125 


<210>  31
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding PFTG

<400>  31
tctagaagcg actgggaccc cgtggtgaag gaatggctgg tggacaccgg ctactgctgt       60

gccggcggaa tcgccaacgc cgaggatggc gtggtgttcg ccgctgcagc cgacgatgac      120

gacggctgga gcaagctgta caaggacgac cacgaggagg acaccatcgg cgaggacggc      180

aacgcctgtg gcaaggtgtc catcaacgag gccagcacca tcaaggccgc cgtggacgac      240

ggcagcgccc ccaacggagt gtggatcggc ggccagaaat acaaggttgt gaggcccgag      300

aagggcttcg agtacaacga ctgtaccttc gacatcacca tgtgtgccag aagcaaaggc      360

ggagcccacc tgatcaagac ccccaacggc agcatcgtga tcgccctgta cgacgaggag      420

aaggagcagg acaagggcaa cagcagaacc agcgccctgg ccttcgccga gtacctgcac      480

cagagcggct actgatga                                                    498


