                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Zhang, Lin
 
<120>  Cells Having Gene Duplications and Uses Thereof

<130>  PC072565A

<150>  US 62/706,075
<151>  2020-07-30

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  785
<212>  PRT
<213>  Cricetulus griseus

<400>  1

Met Ala Gln Pro Ser Ser Pro Gly Gly Glu Gly Pro Gln Phe Gly Ala 
1               5                   10                  15      


Thr Gly Asp Ser Arg Asp Ala Leu Ser Leu Glu Glu Ile Leu Arg Leu 
            20                  25                  30          


Tyr Asn Gln Pro Ile Asn Glu Glu Gln Ala Trp Ala Val Cys Phe Gln 
        35                  40                  45              


Cys Cys Gly Ser Leu Arg Ala Thr Ala Ala Arg Arg Gln Pro His Arg 
    50                  55                  60                  


Arg Val Arg Ser Ala Ala Gln Ile Arg Val Trp Arg Asp Gly Ala Val 
65                  70                  75                  80  


Thr Leu Ala Pro Ala Ala Gly Glu Glu Gly Glu Pro Pro Pro Ala Ser 
                85                  90                  95      


Gly Lys Leu Gly Tyr Ser His Cys Thr Glu Thr Glu Val Ile Glu Ser 
            100                 105                 110         


Leu Gly Ile Ile Ile Tyr Lys Ala Leu Asp Tyr Gly Leu Lys Glu Asn 
        115                 120                 125             


Glu Glu Arg Glu Leu Ser Pro Pro Leu Glu Gln Leu Ile Asp Gln Met 
    130                 135                 140                 


Ala Asn Thr Val Glu Ala Asp Gly Asn Ser Asp Glu Gly Tyr Glu Ala 
145                 150                 155                 160 


Ala Asp Glu Gly Pro Glu Asp Glu Asp Gly Gly Lys Arg Asn Ile Ser 
                165                 170                 175     


Ala Ile Arg Ser Tyr Gln Asp Val Met Lys Ile Cys Ala Ala His Leu 
            180                 185                 190         


Pro Ala Glu Ser Glu Ala Pro Asn His Tyr Gln Ala Val Cys Arg Ala 
        195                 200                 205             


Leu Phe Ala Glu Thr Met Glu Leu His Thr Phe Leu Thr Lys Ile Lys 
    210                 215                 220                 


Ser Ala Lys Glu Asn Leu Lys Lys Ile Gln Glu Met Glu Lys Thr Asp 
225                 230                 235                 240 


Glu Ser Ser Thr Asp Leu Glu Asp Leu Lys Asn Ala Asp Trp Ala Arg 
                245                 250                 255     


Phe Trp Val Gln Val Met Arg Asp Leu Arg Asn Gly Val Lys Leu Lys 
            260                 265                 270         


Lys Val Gln Gln Arg Gln Tyr Asn Pro Leu Pro Ile Glu Tyr Gln Leu 
        275                 280                 285             


Thr Pro Tyr Glu Met Leu Met Asp Asp Ile Arg Cys Arg Arg Tyr Thr 
    290                 295                 300                 


Leu Arg Lys Val Met Val Asn Gly Asp Ile Pro Pro Arg Leu Arg Lys 
305                 310                 315                 320 


Ser Ala His Glu Ile Ile Leu Asp Phe Ile Arg Ser Arg Pro Pro Leu 
                325                 330                 335     


Asn Pro Ala Ser Ala Arg Lys Leu Lys Pro Thr Pro Pro Arg Pro Arg 
            340                 345                 350         


Ser Leu His Glu Arg Ile Leu Glu Glu Ile Lys Ala Glu Arg Lys Leu 
        355                 360                 365             


Arg Pro Val Ser Pro Glu Glu Ile Arg Arg Ser Lys Leu Asp Val Thr 
    370                 375                 380                 


Thr Pro Asp Ser Ser Lys Asn Val Gly Glu Ser Ser Met Val Asn Gly 
385                 390                 395                 400 


Gly Leu Ala Ser Gln Thr Lys Glu Asn Gly Leu Gly Ala Ala Gln Pro 
                405                 410                 415     


Gly Pro Ala Gln Arg Lys Lys Leu Leu Lys Ala Pro Thr Leu Ala Glu 
            420                 425                 430         


Leu Asp Ser Ser Asp Ser Glu Glu Glu Thr Leu His Lys Ser Thr Ser 
        435                 440                 445             


Ser Ser Ser Ala Ser Pro Ser Leu Tyr Glu Asp Pro Val Leu Glu Ala 
    450                 455                 460                 


Met Cys Thr Arg Lys Lys Pro Pro Lys Phe Leu Pro Ile Ser Ser Thr 
465                 470                 475                 480 


Pro Gln Pro Glu Arg Arg Gln Pro Pro Gln Arg Arg His Ser Ile Glu 
                485                 490                 495     


Lys Glu Thr Pro Thr Asn Val Arg Gln Phe Leu Pro Pro Ser Arg Gln 
            500                 505                 510         


Ser Ser Arg Ser Leu Val Pro Arg Ile Thr Ser Val Trp Pro Arg Thr 
        515                 520                 525             


Pro Phe Arg Pro Leu Phe Ser Thr Ile Gln Thr Ala Ser Leu Leu Ser 
    530                 535                 540                 


Ser His Pro Phe Glu Ala Ala Met Phe Gly Val Ala Gly Ala Met Tyr 
545                 550                 555                 560 


Tyr Leu Phe Glu Arg Ala Phe Thr Ser Arg Trp Lys Pro Ser Lys Glu 
                565                 570                 575     


Glu Phe Cys Tyr Pro Val Glu Cys Leu Ala Leu Thr Val Glu Glu Val 
            580                 585                 590         


Met His Ile Arg Gln Val Leu Val Lys Ala Glu Leu Glu Lys Tyr Gln 
        595                 600                 605             


Gln Tyr Lys Asp Val Tyr Thr Ala Leu Lys Lys Gly Lys Leu Cys Phe 
    610                 615                 620                 


Cys Cys Arg Thr Arg Arg Phe Ser Phe Phe Thr Trp Ser Tyr Thr Cys 
625                 630                 635                 640 


Gln Phe Cys Lys Arg Pro Val Cys Ser Gln Cys Cys Lys Lys Met Arg 
                645                 650                 655     


Leu Pro Ser Lys Pro Tyr Ser Thr Leu Pro Ile Phe Ser Leu Gly Pro 
            660                 665                 670         


Ser Ala Leu Gln Arg Gly Glu Ser Cys Pro Arg Pro Glu Lys Ser Ser 
        675                 680                 685             


Thr Ala His His Arg Pro Leu Arg Ser Ile Ala Arg Phe Ser Ser Lys 
    690                 695                 700                 


Ser Lys Ser Val Asp Lys Ser Asp Glu Glu Leu Gln Phe Pro Lys Glu 
705                 710                 715                 720 


Phe Met Glu Asp Trp Ser Thr Met Glu Val Cys Val Asp Cys Lys Lys 
                725                 730                 735     


Phe Ile Ser Glu Ile Ile Ser Ser Ser Arg Arg Ser Leu Val Leu Ala 
            740                 745                 750         


Asn Lys Arg Ala Arg Leu Lys Arg Lys Thr Gln Ser Phe Tyr Met Ser 
        755                 760                 765             


Ser Ala Gly Pro Ser Glu Tyr Cys Pro Ser Glu Arg Thr Ile Asn Glu 
    770                 775                 780                 


Ile 
785 


<210>  2
<211>  559
<212>  PRT
<213>  Cricetulus griseus

<400>  2

Met Ser Ser Glu Val Ile Arg Ala Thr Ala Gly Met Val Leu Ala Glu 
1               5                   10                  15      


Leu Tyr Val Ser Asp Arg Glu Gly Asn Asp Ala Thr Gly Asp Gly Thr 
            20                  25                  30          


Lys Glu Lys Pro Phe Lys Thr Gly Leu Lys Ala Leu Met Thr Val Gly 
        35                  40                  45              


Lys Glu Pro Phe Pro Thr Ile Tyr Val Asp Ser Gln Lys Glu Asn Glu 
    50                  55                  60                  


Arg Trp Asp Val Ile Ser Lys Ser Gln Met Lys Asn Ile Lys Lys Met 
65                  70                  75                  80  


Trp His Arg Glu Gln Met Lys Asn Asp Ser Arg Glu Lys Lys Glu Ala 
                85                  90                  95      


Glu Asp Asn Leu Arg Arg Glu Lys Asn Leu Glu Glu Ala Lys Lys Ile 
            100                 105                 110         


Ile Ile Lys Asn Asp Pro Ser Leu Pro Glu Pro Ala Cys Val Lys Ile 
        115                 120                 125             


Cys Ala Leu Glu Gly Tyr Arg Gly Gln Arg Val Lys Val Phe Gly Trp 
    130                 135                 140                 


Val His Arg Leu Leu Arg Glu Gly Lys Asn Leu Met Phe Leu Val Leu 
145                 150                 155                 160 


Arg Asp Gly Thr Gly Tyr Leu Gln Cys Val Leu Ser Asp Asp Leu Cys 
                165                 170                 175     


Gln Cys Tyr Asn Gly Val Val Leu Ser Thr Glu Ser Ser Val Ala Val 
            180                 185                 190         


Tyr Gly Thr Leu Asn Leu Thr Pro Lys Gly Lys Gln Ala Pro Gly Gly 
        195                 200                 205             


His Glu Leu Ser Cys Asp Phe Trp Glu Leu Val Gly Leu Ala Pro Ala 
    210                 215                 220                 


Gly Gly Ala Asp Asn Leu Ile Asn Glu Glu Ser Asp Val Asp Val Gln 
225                 230                 235                 240 


Leu Asn Asn Arg His Met Met Ile Arg Gly Glu Asn Met Ser Lys Ile 
                245                 250                 255     


Leu Lys Ala Arg Ser Met Ile Thr Arg Cys Phe Arg Asp His Phe Phe 
            260                 265                 270         


Asp Arg Gly Tyr Cys Glu Val Thr Thr Pro Thr Leu Val Gln Thr Gln 
        275                 280                 285             


Val Glu Gly Gly Ala Thr Leu Phe Lys Leu Asp Tyr Phe Gly Glu Glu 
    290                 295                 300                 


Ala Phe Leu Thr Gln Ser Ser Gln Leu Tyr Leu Glu Thr Cys Leu Pro 
305                 310                 315                 320 


Ala Leu Gly Asp Val Phe Cys Ile Ala Gln Ser Tyr Arg Ala Glu Gln 
                325                 330                 335     


Ser Arg Thr Arg Arg His Leu Ala Glu Phe Thr His Val Glu Ala Glu 
            340                 345                 350         


Cys Pro Phe Leu Thr Phe Glu Asp Leu Leu Asn Arg Leu Glu Asp Leu 
        355                 360                 365             


Val Cys Asp Val Val Asp Arg Val Leu Lys Ser Pro Val Ala Ser Ile 
    370                 375                 380                 


Val Tyr Asp Leu Asn Pro Asn Phe Lys Pro Pro Lys Arg Pro Phe Arg 
385                 390                 395                 400 


Arg Met Asn Tyr Ser Asp Ala Ile Glu Trp Leu Arg Glu His Asp Val 
                405                 410                 415     


Lys Lys Glu Asp Gly Thr Leu Tyr Glu Phe Gly Asp Asp Ile Pro Glu 
            420                 425                 430         


Ala Pro Glu Arg Leu Met Thr Asp Thr Ile Asn Glu Pro Ile Leu Leu 
        435                 440                 445             


Cys Arg Phe Pro Val Glu Ile Lys Ser Phe Tyr Met Gln Arg Cys Pro 
    450                 455                 460                 


Glu Asp Pro Arg Leu Thr Glu Ser Val Asp Val Leu Met Pro Asn Val 
465                 470                 475                 480 


Gly Glu Ile Val Gly Gly Ser Met Arg Ser Trp Asp Ser Glu Glu Ile 
                485                 490                 495     


Leu Glu Gly Tyr Lys Arg Glu Gly Ile Asp Pro Ala Pro Tyr Tyr Trp 
            500                 505                 510         


Tyr Thr Asp Gln Arg Lys Tyr Gly Thr Cys Pro His Gly Gly Tyr Gly 
        515                 520                 525             


Leu Gly Leu Glu Arg Phe Leu Ser Trp Ile Leu Asn Arg Tyr His Ile 
    530                 535                 540                 


Arg Asp Val Cys Leu Tyr Pro Arg Phe Val Gln Arg Cys Arg Pro 
545                 550                 555                 


<210>  3
<211>  151
<212>  PRT
<213>  Cricetulus griseus

<400>  3

Met Ala Pro Arg Lys Gly Lys Glu Lys Lys Glu Glu Gln Val Ile Ser 
1               5                   10                  15      


Leu Gly Pro Gln Val Ala Glu Gly Glu Asn Val Phe Gly Val Cys His 
            20                  25                  30          


Ile Phe Ala Ser Phe Asn Asp Thr Phe Val His Val Thr Asp Leu Ser 
        35                  40                  45              


Gly Lys Glu Thr Ile Cys Arg Val Thr Gly Gly Met Lys Val Lys Ala 
    50                  55                  60                  


Asp Arg Asp Glu Ser Ser Pro Tyr Ala Ala Met Leu Ala Ala Gln Asp 
65                  70                  75                  80  


Val Ala Gln Arg Cys Lys Glu Leu Gly Ile Thr Ala Leu His Ile Lys 
                85                  90                  95      


Leu Arg Ala Thr Gly Gly Asn Arg Thr Lys Thr Pro Gly Pro Gly Ala 
            100                 105                 110         


Gln Ser Ala Leu Arg Ala Leu Ala Arg Ser Gly Met Lys Ile Gly Arg 
        115                 120                 125             


Ile Glu Asp Val Thr Pro Ile Pro Ser Asp Ser Thr Arg Arg Lys Gly 
    130                 135                 140                 


Gly Arg Arg Gly Arg Arg Leu 
145                 150     


<210>  4
<211>  60
<212>  PRT
<213>  Cricetulus griseus

<400>  4

Met Asp Ala Ile Ser Gln Ser Pro Val Asp Val Leu Leu Pro Lys His 
1               5                   10                  15      


Ile Leu Asp Ile Trp Ala Ile Val Leu Ile Ile Leu Ala Thr Ile Val 
            20                  25                  30          


Ile Met Thr Ser Leu Phe Leu Cys Pro Ala Thr Ala Val Ile Ile Tyr 
        35                  40                  45              


Arg Met Arg Thr His Pro Val Leu Asn Gly Ala Val 
    50                  55                  60  


<210>  5
<211>  617
<212>  PRT
<213>  Cricetulus griseus

<400>  5

Met Asp Leu Lys Thr Ala Val Phe Asn Ala Ala Arg Asp Gly Lys Leu 
1               5                   10                  15      


Arg Leu Leu Thr Lys Leu Leu Ala Ser Lys Ser Lys Glu Glu Val Ser 
            20                  25                  30          


Ser Leu Ile Ser Glu Lys Thr Asn Gly Ala Thr Pro Leu Leu Met Ala 
        35                  40                  45              


Ala Arg Tyr Gly His Leu Asp Met Val Glu Phe Leu Leu Glu Gln Cys 
    50                  55                  60                  


Ser Ala Ser Ile Glu Val Gly Gly Ser Val Asn Phe Asp Gly Glu Thr 
65                  70                  75                  80  


Ile Glu Gly Ala Pro Pro Leu Trp Ala Ala Ser Ala Ala Gly His Leu 
                85                  90                  95      


Lys Val Val Gln Ser Leu Leu Asn His Gly Ala Ser Val Asn Asn Thr 
            100                 105                 110         


Thr Leu Thr Asn Ser Thr Pro Leu Arg Ala Ala Cys Phe Asp Gly His 
        115                 120                 125             


Leu Glu Ile Val Lys Tyr Leu Val Glu His Lys Ala Asp Leu Glu Val 
    130                 135                 140                 


Ser Asn Arg His Gly His Thr Cys Leu Met Ile Ser Cys Tyr Lys Gly 
145                 150                 155                 160 


His Lys Glu Ile Ala Gln Tyr Leu Leu Glu Lys Gly Ala Asp Val Asn 
                165                 170                 175     


Arg Lys Ser Val Lys Gly Asn Thr Ala Leu His Asp Cys Ala Glu Ser 
            180                 185                 190         


Gly Ser Leu Asp Ile Met Lys Met Leu Leu Met Tyr Cys Ala Lys Met 
        195                 200                 205             


Glu Lys Asp Gly Tyr Gly Met Thr Pro Leu Leu Ser Ala Ser Val Thr 
    210                 215                 220                 


Gly His Thr Asn Ile Val Asp Phe Leu Thr His His Ala Gln Thr Ser 
225                 230                 235                 240 


Lys Thr Glu Arg Ile Asn Ala Leu Glu Leu Leu Gly Ala Thr Phe Val 
                245                 250                 255     


Asp Lys Lys Arg Asp Leu Leu Gly Ala Leu Lys Tyr Trp Lys Lys Ala 
            260                 265                 270         


Met Asn Met Arg Tyr Ser Asp Arg Thr Asn Ile Ile Ser Lys Pro Val 
        275                 280                 285             


Pro Gln Thr Leu Ile Met Ala Tyr Asp Tyr Ala Lys Glu Val Asn Ser 
    290                 295                 300                 


Ala Glu Glu Leu Glu Gly Leu Ile Ala Asp Pro Asp Glu Met Arg Met 
305                 310                 315                 320 


Gln Ala Leu Leu Ile Arg Glu Arg Ile Leu Gly Pro Ser His Pro Asp 
                325                 330                 335     


Thr Ser Tyr Tyr Ile Arg Tyr Arg Gly Ala Val Tyr Ala Asp Ser Gly 
            340                 345                 350         


Asn Phe Lys Arg Cys Ile Asn Leu Trp Lys Tyr Ala Leu Asp Met Gln 
        355                 360                 365             


Gln Ser Asn Leu Asp Pro Leu Ser Pro Met Thr Ala Ser Ser Leu Leu 
    370                 375                 380                 


Ser Phe Ala Glu Leu Phe Ser Phe Met Leu Gln Asp Arg Ala Lys Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Thr Val Thr Phe Asp Asp Leu Met Gly Ile Leu Cys 
                405                 410                 415     


Lys Ser Val Leu Glu Ile Glu Arg Ala Ile Lys Gln Thr Gln Cys Pro 
            420                 425                 430         


Ala Asp Pro Leu Gln Leu Asn Lys Ala Leu Ser Ile Ile Leu His Leu 
        435                 440                 445             


Ile Cys Leu Leu Glu Lys Val Pro Cys Thr Leu Glu Gln Asp His Phe 
    450                 455                 460                 


Lys Lys Gln Thr Ile Tyr Arg Phe Leu Lys Leu His Pro Arg Gly Lys 
465                 470                 475                 480 


Asn Asn Phe Ser Pro Leu His Leu Ala Val Asp Lys Asn Thr Thr Cys 
                485                 490                 495     


Val Gly Arg Tyr Pro Val Cys Lys Phe Pro Ser Leu Gln Val Thr Ala 
            500                 505                 510         


Ile Leu Ile Glu Cys Gly Ala Asp Val Asn Val Arg Asp Ser Asp Asp 
        515                 520                 525             


Asn Ser Pro Leu His Ile Ala Ala Leu Asn Asn His Pro Asp Ile Met 
    530                 535                 540                 


Asn Leu Leu Ile Lys Ser Gly Ala His Phe Asp Ala Thr Asn Leu His 
545                 550                 555                 560 


Lys Gln Thr Ala Ser Asp Leu Leu Asp Glu Lys Glu Ile Ala Lys Asn 
                565                 570                 575     


Leu Ile Gln Pro Ile Asn His Ile Thr Leu Gln Cys Leu Ala Ala Arg 
            580                 585                 590         


Val Ile Val Asn His Arg Ile Tyr Tyr Lys Gly Asn Ile Pro Glu Lys 
        595                 600                 605             


Leu Glu Thr Phe Val Ser Leu His Arg 
    610                 615         


<210>  6
<211>  212
<212>  PRT
<213>  Cricetulus griseus

<400>  6

Met Ile Pro Gly Pro Arg Leu Leu Leu Pro Ala Val Leu Cys Leu Gly 
1               5                   10                  15      


Leu Gly Thr Leu Val Ser Ser Ser Gly Ser Ser Gly Val Arg Lys Arg 
            20                  25                  30          


Gly Pro Ser Val Thr Ala Lys Val Phe Phe Asp Val Lys Ile Gly Asp 
        35                  40                  45              


Lys Asp Val Gly Arg Ile Val Ile Gly Leu Phe Gly Lys Val Val Pro 
    50                  55                  60                  


Lys Thr Val Glu Asn Phe Val Ala Leu Ala Thr Gly Glu Lys Gly Tyr 
65                  70                  75                  80  


Gly Tyr Lys Gly Ser Ile Phe His Arg Val Ile Lys Asp Phe Met Ile 
                85                  90                  95      


Gln Gly Gly Asp Phe Thr Ala Arg Asp Gly Thr Gly Gly Met Ser Ile 
            100                 105                 110         


Tyr Gly Glu Thr Phe Pro Asp Glu Asn Phe Lys Leu Lys His Tyr Gly 
        115                 120                 125             


Ile Gly Trp Val Ser Met Ala Asn Ala Gly Pro Asp Thr Asn Gly Ser 
    130                 135                 140                 


Gln Phe Phe Ile Thr Leu Thr Lys Pro Ser Trp Leu Asp Gly Lys His 
145                 150                 155                 160 


Val Val Phe Gly Lys Val Leu Asp Gly Met Thr Val Val His Ser Ile 
                165                 170                 175     


Glu Leu Gln Ala Thr Asp Asp His Asp Arg Pro Phe Thr Asp Cys Thr 
            180                 185                 190         


Ile Val Asn Ser Gly Lys Ile Asp Val Lys Thr Pro Phe Val Val Glu 
        195                 200                 205             


Val Pro Asp Trp 
    210         


<210>  7
<211>  455
<212>  PRT
<213>  Cricetulus griseus

<400>  7

Met Lys Leu Arg Glu Tyr Glu Ala Ala Leu Asn Ser Lys Asp Ala Ala 
1               5                   10                  15      


Leu Ala Thr Ala Leu Gly Asp Lys Lys Ser Leu Glu Gly Asp Leu Glu 
            20                  25                  30          


Asp Leu Lys Asp Gln Ile Ala Gln Leu Glu Ala Ser Leu Ser Ala Ala 
        35                  40                  45              


Lys Lys Gln Leu Ala Asp Glu Thr Leu Leu Lys Val Asp Leu Glu Asn 
    50                  55                  60                  


Arg Cys Gln Ser Leu Thr Glu Asp Leu Glu Phe Arg Lys Asn Met Tyr 
65                  70                  75                  80  


Glu Glu Glu Ile Asn Glu Thr Arg Arg Lys His Glu Thr Arg Leu Val 
                85                  90                  95      


Glu Val Asp Ser Gly Arg Gln Ile Glu Tyr Glu Tyr Lys Leu Ala Gln 
            100                 105                 110         


Ala Leu His Glu Met Arg Glu Gln His Asp Ala Gln Val Arg Leu Tyr 
        115                 120                 125             


Lys Glu Glu Leu Glu Gln Thr Tyr His Ala Lys Leu Glu Asn Ala Arg 
    130                 135                 140                 


Leu Ser Ser Glu Met Asn Thr Ser Thr Val Asn Ser Ala Arg Glu Glu 
145                 150                 155                 160 


Leu Met Glu Ser Arg Met Arg Ile Glu Ser Leu Ser Ser Gln Leu Ser 
                165                 170                 175     


Asn Leu Gln Lys Glu Ser Arg Ala Cys Leu Glu Lys Ile Gln Glu Leu 
            180                 185                 190         


Glu Asp Met Leu Ala Lys Glu Lys Asp Asn Ser Arg Arg Met Leu Ser 
        195                 200                 205             


Asp Lys Glu Arg Glu Met Ala Glu Ile Arg Asp Gln Met Gln Gln Gln 
    210                 215                 220                 


Leu Asn Asp Tyr Glu Gln Leu Leu Asp Val Lys Leu Ala Leu Asp Met 
225                 230                 235                 240 


Glu Ile Ser Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Glu Arg Leu 
                245                 250                 255     


Lys Leu Ser Pro Ser Pro Ser Ser Arg Val Thr Val Ser Arg Ala Ser 
            260                 265                 270         


Ser Ser Arg Ser Val Arg Thr Thr Arg Gly Lys Arg Lys Arg Val Asp 
        275                 280                 285             


Val Glu Glu Ser Glu Ala Ser Ser Ser Val Ser Ile Ser His Ser Ala 
    290                 295                 300                 


Ser Ala Thr Gly Asn Val Cys Ile Glu Glu Ile Asp Val Asp Gly Lys 
305                 310                 315                 320 


Phe Ile Arg Leu Lys Asn Thr Ser Glu Gln Asp Gln Pro Met Gly Gly 
                325                 330                 335     


Trp Glu Met Ile Arg Lys Ile Gly Asp Thr Ser Val Ser Tyr Lys Tyr 
            340                 345                 350         


Thr Ser Arg Tyr Val Leu Lys Ala Gly Gln Thr Val Thr Ile Trp Ala 
        355                 360                 365             


Ala Asn Ala Gly Val Thr Ala Ser Pro Pro Thr Asp Leu Ile Trp Lys 
    370                 375                 380                 


Asn Gln Asn Ser Trp Gly Thr Gly Glu Asp Val Lys Val Ile Leu Lys 
385                 390                 395                 400 


Asn Ser Gln Gly Glu Glu Val Ala Gln Arg Ser Thr Val Phe Lys Thr 
                405                 410                 415     


Thr Ile Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Ile Gly Val 
            420                 425                 430         


Val Ile Glu Glu Glu Arg Phe His Gln Gln Gly Ala Pro Arg Ala Ser 
        435                 440                 445             


Asn Arg Ser Cys Ala Ile Met 
    450                 455 


<210>  8
<211>  604
<212>  PRT
<213>  Cricetulus griseus

<400>  8

Met Ala Gly Gly Arg His Lys Pro Pro Ser Ala Ser Ser Trp Asn Arg 
1               5                   10                  15      


Val Arg Glu Lys Met Phe Ser Arg Val Arg Ala Ile Val Thr Pro Cys 
            20                  25                  30          


Thr Leu Thr Cys Arg His Leu His Leu Lys Glu Lys Gly Lys Pro Leu 
        35                  40                  45              


Met Leu Asn Pro Arg Thr Asn Lys Gly Met Ala Phe Thr Leu Gln Glu 
    50                  55                  60                  


Arg Gln Met Leu Gly Leu Gln Gly Leu Leu Pro Pro Lys Ile Glu Thr 
65                  70                  75                  80  


Gln Asp Ile Gln Ala Leu Arg Phe His Arg Asn Leu Lys Lys Met Thr 
                85                  90                  95      


Ser Pro Leu Glu Lys Tyr Ile Tyr Ile Met Gly Ile Gln Glu Arg Asn 
            100                 105                 110         


Glu Lys Leu Phe Tyr Arg Ile Leu Gln Asp Asp Ile Glu Ser Leu Met 
        115                 120                 125             


Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Ser Gln Tyr Gly 
    130                 135                 140                 


His Ile Phe Arg Arg Pro Lys Gly Leu Phe Ile Ser Ile Ser Asp Arg 
145                 150                 155                 160 


Gly His Val Arg Ser Ile Val Asp Asn Trp Pro Glu Asn His Val Lys 
                165                 170                 175     


Ala Val Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly Asp Leu 
            180                 185                 190         


Gly Val Tyr Gly Met Gly Ile Pro Val Gly Lys Leu Cys Leu Tyr Thr 
        195                 200                 205             


Ala Cys Ala Gly Ile Gln Pro Glu Lys Cys Leu Pro Val Cys Ile Asp 
    210                 215                 220                 


Val Gly Thr Asp Asn Lys Ala Leu Leu Lys Asp Pro Phe Tyr Met Gly 
225                 230                 235                 240 


Leu Tyr Gln Lys Arg Asp Arg Ser Gln Leu Tyr Asp Asp Leu Ile Asp 
                245                 250                 255     


Glu Phe Met Lys Ala Ile Thr Asp Arg Tyr Gly Arg Asn Thr Leu Ile 
            260                 265                 270         


Gln Phe Glu Asp Phe Gly Asn His Asn Ala Phe Arg Phe Leu Arg Lys 
        275                 280                 285             


Tyr Arg Glu Lys Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly Thr Ala 
    290                 295                 300                 


Ala Val Ala Leu Ser Gly Leu Leu Ala Thr Gln Lys Val Ile Asn Lys 
305                 310                 315                 320 


Pro Val Ser Glu His Lys Ile Leu Phe Leu Gly Ala Gly Glu Ala Ala 
                325                 330                 335     


Leu Gly Ile Ala Asn Leu Ile Val Met Ser Met Val Glu Ser Gly Leu 
            340                 345                 350         


Ser Glu Glu Glu Ala Arg Arg Lys Val Trp Met Phe Asp Lys Asn Gly 
        355                 360                 365             


Leu Leu Val Lys Gly Arg Ser Ala Ser Ile Asp Ser Asn Gln Glu Pro 
    370                 375                 380                 


Phe Ala His Gly Ala Pro Glu Asn Val Pro Gly Thr Phe Glu Asp Ala 
385                 390                 395                 400 


Val Asn Lys Leu Lys Pro Ser Val Ile Ile Gly Val Ala Gly Ala Gly 
                405                 410                 415     


Arg Leu Phe Thr Pro Gly Val Ile Lys Ala Met Ala Ser Ile Asn Glu 
            420                 425                 430         


Arg Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ala Gln Ala Glu Cys 
        435                 440                 445             


Thr Ala Glu Glu Ala Tyr Thr Leu Thr Glu Gly Arg Cys Leu Phe Ala 
    450                 455                 460                 


Ser Gly Ser Pro Phe Glu Pro Val Lys Leu Gln Asp Gly Arg Val Phe 
465                 470                 475                 480 


Thr Pro Gly Gln Gly Asn Asn Ala Tyr Ile Phe Pro Gly Val Ala Leu 
                485                 490                 495     


Ala Val Ile Leu Cys Gln Thr Arg His Ile Ser Asp Ser Val Phe Leu 
            500                 505                 510         


Glu Ala Ala Lys Ala Leu Thr Ser Gln Leu Thr Asp Glu Glu Leu Ala 
        515                 520                 525             


Gln Gly Arg Leu Tyr Pro Ser Leu Ala Asn Ile Gln Glu Val Ser Val 
    530                 535                 540                 


Asn Ile Ala Ile Lys Val Thr Glu Tyr Leu Tyr Ala Asn Lys Met Ala 
545                 550                 555                 560 


Phe Arg Tyr Pro Glu Pro Glu Asp Lys Ala Lys Tyr Val Lys Glu Arg 
                565                 570                 575     


Ile Trp Arg Ser Asp Tyr Val Ser Leu Leu Pro Asp Val Tyr Asp Trp 
            580                 585                 590         


Pro Glu Ser Ser Leu Lys Pro Pro Gln Ile Ser Glu 
        595                 600                 


<210>  9
<211>  650
<212>  PRT
<213>  Cricetulus griseus

<400>  9

Met Leu Gln Glu Ala Gly Gly Gly Val Val Gly Ala Ala Gly Gly Gly 
1               5                   10                  15      


Ala Ala Thr Ala Glu Ala Pro Ala Gly Gly Asn Lys Met Ala Asp Phe 
            20                  25                  30          


Glu Glu Leu Arg Asn Met Val Ser Ser Phe Arg Val Ser Glu Leu Gln 
        35                  40                  45              


Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly Arg Lys His Asp 
    50                  55                  60                  


Leu Leu Met Arg Ala Leu His Leu Leu Lys Ser Gly Cys Ser Pro Ala 
65                  70                  75                  80  


Val Gln Ile Lys Ile Arg Glu Leu Tyr Arg Arg Arg Tyr Pro Arg Thr 
                85                  90                  95      


Leu Glu Gly Leu Ser Asp Leu Ser Thr Ile Lys Ser Ser Val Phe Ser 
            100                 105                 110         


Leu Asp Gly Ser Ser Ser Pro Val Glu Pro Asp Leu Ala Val Ala Gly 
        115                 120                 125             


Ile His Ser Leu Pro Ser Ser Ser Ile Thr Pro His Ser Pro Ser Ser 
    130                 135                 140                 


Pro Val Gly Ser Val Leu Leu Gln Asp Ser Lys Pro Thr Phe Glu Met 
145                 150                 155                 160 


Gln Gln Pro Ser Pro Pro Ile Pro Pro Val His Pro Asp Val Gln Leu 
                165                 170                 175     


Lys Asn Leu Pro Phe Tyr Asp Val Leu Asp Val Leu Ile Lys Pro Thr 
            180                 185                 190         


Ser Leu Val Gln Ser Ser Ile Gln Arg Phe Gln Glu Lys Phe Phe Ile 
        195                 200                 205             


Phe Ala Leu Thr Pro Gln Gln Val Arg Glu Ile Cys Ile Ser Arg Asp 
    210                 215                 220                 


Phe Leu Pro Gly Gly Arg Arg Asp Tyr Thr Val Gln Val Gln Leu Arg 
225                 230                 235                 240 


Leu Cys Leu Ala Glu Thr Ser Cys Pro Gln Glu Asp Asn Tyr Pro Asn 
                245                 250                 255     


Ser Leu Cys Ile Lys Val Asn Gly Lys Leu Phe Pro Leu Pro Gly Tyr 
            260                 265                 270         


Ala Pro Pro Pro Lys Asn Gly Ile Glu Gln Lys Arg Pro Gly Arg Pro 
        275                 280                 285             


Leu Asn Ile Thr Ser Leu Val Arg Leu Ser Ser Ala Val Pro Asn Gln 
    290                 295                 300                 


Ile Ser Ile Ser Trp Ala Ser Glu Ile Gly Lys Asn Tyr Ser Met Ser 
305                 310                 315                 320 


Val Tyr Leu Val Arg Gln Leu Thr Ser Ala Met Leu Leu Gln Arg Leu 
                325                 330                 335     


Lys Met Lys Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile Lys 
            340                 345                 350         


Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Ile Ala Thr Thr Ser Leu 
        355                 360                 365             


Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg Leu Thr Ile Pro 
    370                 375                 380                 


Cys Arg Ala Val Thr Cys Thr His Leu Gln Cys Phe Asp Ala Ala Leu 
385                 390                 395                 400 


Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Ile Cys Pro Val Cys 
                405                 410                 415     


Asp Lys Lys Ala Ala Tyr Glu Ser Leu Ile Leu Asp Gly Leu Phe Met 
            420                 425                 430         


Glu Ile Leu Asn Asp Cys Ser Asp Val Asp Glu Ile Lys Phe Gln Glu 
        435                 440                 445             


Asp Gly Ser Trp Cys Pro Met Arg Pro Lys Lys Glu Ala Met Lys Val 
    450                 455                 460                 


Thr Ser Gln Pro Cys Thr Lys Ile Glu Ser Ser Ser Val Phe Ser Lys 
465                 470                 475                 480 


Pro Cys Ser Val Ala Val Ala Ser Asp Ala Asn Lys Lys Lys Ile Asp 
                485                 490                 495     


Val Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Glu Asp Pro 
            500                 505                 510         


Pro Ala Lys Arg Lys Cys Ile Phe Met Ser Glu Thr Gln Ser Ser Pro 
        515                 520                 525             


Thr Lys Gly Val Leu Met Tyr Gln Pro Ser Ser Val Arg Val Pro Ser 
    530                 535                 540                 


Val Thr Ser Val Asp Pro Ala Ala Ile Pro Pro Ser Leu Thr Asp Tyr 
545                 550                 555                 560 


Ser Val Pro Phe His His Thr Pro Val Ser Ser Met Ser Ser Asp Leu 
                565                 570                 575     


Pro Gly Leu Asp Phe Leu Ser Leu Ile Pro Val Asp Pro Gln Gln Tyr 
            580                 585                 590         


Cys Pro Pro Met Phe Leu Asp Ser Leu Thr Ser Pro Leu Thr Ala Ser 
        595                 600                 605             


Ser Thr Ser Val Thr Thr Thr Ser Pro His Glu Ser Ser Thr His Val 
    610                 615                 620                 


Ser Ser Ser Ser Ser Arg Ser Glu Thr Gly Val Ile Thr Ser Ser Gly 
625                 630                 635                 640 


Ser Asn Ile Pro Asp Ile Ile Ser Leu Asp 
                645                 650 


<210>  10
<211>  736
<212>  PRT
<213>  Cricetulus griseus

<400>  10

Met Asp Asp Leu Thr Leu Leu Asp Leu Leu Glu Cys Pro Val Cys Phe 
1               5                   10                  15      


Glu Lys Leu Asp Val Thr Ala Lys Val Leu Pro Cys Gln His Thr Phe 
            20                  25                  30          


Cys Lys Pro Cys Leu Gln Arg Ile Phe Lys Ala His Lys Glu Leu Arg 
        35                  40                  45              


Cys Pro Glu Cys Arg Thr Leu Val Phe Cys Ser Ile Glu Ala Leu Pro 
    50                  55                  60                  


Ala Asn Leu Leu Leu Val Arg Leu Leu Asp Gly Val Arg Ser Gly Gln 
65                  70                  75                  80  


Asn Ser Trp Lys Arg Gly Ser Phe Arg Arg Pro Arg Ile Leu Thr Leu 
                85                  90                  95      


Gln Asp Ser Arg Lys Ser Lys Thr Ser Pro Arg Ser Leu Gln Ala Ser 
            100                 105                 110         


Pro Phe Arg Leu Val Pro Ser Val Arg Ile His Met Asp Gly Val Pro 
        115                 120                 125             


Arg Ala Lys Ala Leu Cys Asn Tyr Arg Gly Lys Asn Pro Gly Asp Leu 
    130                 135                 140                 


Lys Phe Asn Lys Gly Asp Val Ile Leu Leu Arg Arg Gln Leu Asp Glu 
145                 150                 155                 160 


Asn Trp Tyr Gln Gly Glu Ile Asn Gly Val Ser Gly Ile Phe Pro Ala 
                165                 170                 175     


Ser Ser Val Glu Val Ile Lys Gln Leu Pro Gln Pro Pro Pro Leu Cys 
            180                 185                 190         


Arg Ala Leu Tyr Asn Phe Asp Leu Arg Asp Lys Asp Lys Ser Glu Asn 
        195                 200                 205             


Gln Asp Cys Leu Thr Phe Leu Lys Asp Asp Ile Ile Thr Val Ile Ser 
    210                 215                 220                 


Arg Val Asp Glu Asn Trp Ala Glu Gly Lys Leu Gly Asp Lys Val Gly 
225                 230                 235                 240 


Ile Phe Pro Ile Leu Phe Val Glu Pro Asn Leu Ala Ala Arg His Leu 
                245                 250                 255     


Leu Glu Arg Asn Lys Gly His Gln Leu Ser Arg Thr Lys Asn Leu Ser 
            260                 265                 270         


Leu Met Ser Ser Pro Ser Lys Gly Lys Ala Thr Asn Thr Ser Thr Leu 
        275                 280                 285             


Arg Lys Ser Pro Gly Ser Arg Arg Lys Gly Ser Gly Gln Phe Ser Ile 
    290                 295                 300                 


Thr Thr Ala Leu Asn Thr Leu Asn Arg Met Val His Ser Pro Glu Gly 
305                 310                 315                 320 


His Gln Met Val Glu Ile Ser Thr Pro Val Leu Ile Ser Ser Thr Ser 
                325                 330                 335     


Pro Ser Val Phe Thr Gln His Gly Asp Lys Ala Asp Phe Pro Ala Asn 
            340                 345                 350         


Ser Ala Gly Gln Val Ser Thr Ser His Pro Ala Pro Ala Ser Pro Gly 
        355                 360                 365             


His Ser Thr Ala Met Val Ser Val Pro Ser Ser Gln Gln His Leu Ser 
    370                 375                 380                 


Ala Asn Met Phe Val Ala Leu His Ser Tyr Ser Ala His Gly Pro Asn 
385                 390                 395                 400 


Glu Leu Asp Leu Gln Lys Gly Glu Gly Ile Lys Val Leu Gly Lys Tyr 
                405                 410                 415     


Gln Asp Gly Trp Leu Lys Gly Leu Ser Leu Val Thr Gly Arg Ala Gly 
            420                 425                 430         


Ile Phe Pro Ser Asp Tyr Val Ile Pro Val Phe Ser Ser Thr Ala Arg 
        435                 440                 445             


Lys Thr Ser Gly Phe Pro Asp Ser Arg Ser Pro Thr Val Tyr Thr Thr 
    450                 455                 460                 


Trp Ala Leu Pro Thr Ser Ser Val Ser Ser Gln Gly Ser Phe Gln Glu 
465                 470                 475                 480 


Gly Asp Pro Trp Gln Ser Arg Pro Val Lys Ser Val Phe Val Pro Thr 
                485                 490                 495     


Ala Val Val Asn Pro Gln Gly Ser Thr Pro Gly Pro Gly Thr Ser Gly 
            500                 505                 510         


Gln Gly Ser Leu Arg Lys Ser Arg Ser Ile Met Arg Lys Asn Gly Ser 
        515                 520                 525             


Leu Gln Arg Pro Val Gln Ser Gly Ile Pro Thr Phe Met Leu Gly Ser 
    530                 535                 540                 


Leu Arg His Ser Pro Thr Met Met Ile Gly Pro Gln Lys Phe His Phe 
545                 550                 555                 560 


Tyr Lys Pro Gln Gly Met Ala Ser Ser Pro Pro Pro Met Met Val Glu 
                565                 570                 575     


Met Gly Ser Lys Pro Ile Ser Thr Gly Glu Pro Ala Leu Thr Cys Ile 
            580                 585                 590         


Ser Arg Gly Ser Lys Thr Arg Ile His Ser Ala Ser Ser Ser Phe Ile 
        595                 600                 605             


Met Glu Gly Lys Glu Ile Pro Ile Lys Ser Glu Pro Pro Ser Lys Pro 
    610                 615                 620                 


Pro Ala Ser Ala Pro Pro Ser Ile Leu Val Lys Pro Glu Asn Ser Lys 
625                 630                 635                 640 


Asn Gly Ile Glu Lys Gln Val Lys Thr Val Arg Phe Gln Asn Tyr Ser 
                645                 650                 655     


Pro Pro Pro Thr Lys His Tyr Ala Ser His Pro Thr Ser Gly Lys His 
            660                 665                 670         


Glu Gln Pro Ser Thr Leu Lys Gly Ser Gln Ser Glu Ala Lys His Thr 
        675                 680                 685             


Gly Ala Glu Met Thr Ile Leu Phe Ala His Arg Ser Gly Cys His Ser 
    690                 695                 700                 


Gly Gln Gln Thr Asp Leu Arg Arg Lys Ser Ala Phe Gly Lys Thr Met 
705                 710                 715                 720 


Pro Pro Leu Ser Thr Thr Ser Gly Ser Gln Thr Ile Phe Thr Ser Gln 
                725                 730                 735     


