               SEQUENCE LISTING

<110> Università Cattolica del Sacro Cuore

<120> Sviluppo di una nuova proteasi Tobacco Etch Virus (TEV) ingegnerizzata attivabile nel citosol o nel pathway secretorio

<130> BI5515R

<160> 36

<170> BiSSAP 1.3.6

<210> 1
<211> 198
<212> PRT
<213> Mammalia


<400> 1
Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe 
1               5                   10                  15      
Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
            20                  25                  30          
Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
        35                  40                  45              
Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala 
    50                  55                  60                  
Thr Gly His Gly Ser Gly Ser Gly Ser Gly Val Lys Asp Leu Leu Gln 
65                  70                  75                  80  
Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Gly Pro Pro 
                85                  90                  95      
Gly Pro Gly Ser Gly Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
            100                 105                 110         
Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
        115                 120                 125             
Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
    130                 135                 140                 
Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
145                 150                 155                 160 
Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Ser Ser Gly Gly 
                165                 170                 175     
Ser Gly Ser Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
            180                 185                 190         
Glu Leu Leu Lys Leu Glu 
        195             

<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 2
Gly Gly Ser Gly Gly Gly 
1               5       

<210> 3
<211> 236
<212> PRT
<213> Tobacco etch virus


<400> 3
Gly Glu Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser Ser 
1               5                   10                  15      
Thr Ile Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser Leu 
            20                  25                  30          
Tyr Gly Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu Phe 
        35                  40                  45              
Arg Arg Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val Phe 
    50                  55                  60                  
Lys Val Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly Arg 
65                  70                  75                  80  
Asp Met Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro Gln 
                85                  90                  95      
Lys Leu Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu Val 
            100                 105                 110         
Thr Thr Asn Phe Gln Thr Lys Ser Met Ser Ser Met Val Ser Asp Thr 
        115                 120                 125             
Ser Cys Thr Phe Pro Ser Ser Asp Gly Ile Phe Trp Lys His Trp Ile 
    130                 135                 140                 
Gln Thr Lys Asp Gly Gln Cys Gly Ser Pro Leu Val Ser Thr Arg Asp 
145                 150                 155                 160 
Gly Phe Ile Val Gly Ile His Ser Ala Ser Asn Phe Thr Asn Thr Asn 
                165                 170                 175     
Asn Tyr Phe Thr Ser Val Pro Lys Asn Phe Met Glu Leu Leu Thr Asn 
            180                 185                 190         
Gln Glu Ala Gln Gln Trp Val Ser Gly Trp Arg Leu Asn Ala Asp Ser 
        195                 200                 205             
Val Leu Trp Gly Gly His Lys Val Phe Met Val Lys Pro Glu Glu Pro 
    210                 215                 220                 
Phe Gln Pro Val Lys Glu Ala Thr Gln Leu Met Asn 
225                 230                 235     

<210> 4
<211> 261
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 4
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Gly Glu Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn 
            20                  25                  30          
Pro Ile Ser Ser Thr Ile Cys His Leu Thr Gln Glu Ser Asp Gly His 
        35                  40                  45              
Thr Thr Ser Leu Tyr Gly Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn 
    50                  55                  60                  
Lys His Leu Phe Arg Arg Asn Asn Gly Thr Leu Leu Val Gln Ser Leu 
65                  70                  75                  80  
His Gly Val Phe Lys Val Lys Asn Thr Thr Thr Leu Gln Gln His Leu 
                85                  90                  95      
Ile Asp Gly Arg Asp Met Ile Ile Ile Arg Met Pro Lys Asp Phe Pro 
            100                 105                 110         
Pro Phe Pro Gln Lys Leu Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg 
        115                 120                 125             
Ile Cys Leu Val Thr Thr Asn Phe Gln Thr Lys Ser Met Ser Ser Met 
    130                 135                 140                 
Val Ser Asp Thr Ser Ser Thr Phe Pro Ser Ser Asp Gly Ile Phe Trp 
145                 150                 155                 160 
Lys His Trp Ile Gln Thr Lys Asp Gly Gln Cys Gly Ser Pro Leu Val 
                165                 170                 175     
Ser Thr Arg Asp Gly Phe Ile Val Gly Ile His Ser Ala Ser Asn Phe 
            180                 185                 190         
Gly Asn Thr Asn Asn Tyr Phe Thr Ser Val Pro Lys Asn Phe Met Glu 
        195                 200                 205             
Leu Leu Thr Asn Gln Glu Ala Gln Gln Trp Val Ser Gly Trp Arg Leu 
    210                 215                 220                 
Asn Ala Asp Ser Val Leu Trp Gly Gly His Lys Val Phe Met Ser Lys 
225                 230                 235                 240 
Pro Glu Glu Pro Phe Gln Pro Val Lys Glu Ala Thr Gln Leu Met Asn 
                245                 250                 255     
Glu Gly Gly Leu Glu 
            260     

<210> 5
<211> 440
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 5
Gly Glu Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser Ser 
1               5                   10                  15      
Thr Ile Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser Leu 
            20                  25                  30          
Tyr Gly Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu Phe 
        35                  40                  45              
Arg Arg Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val Phe 
    50                  55                  60                  
Lys Val Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly Arg 
65                  70                  75                  80  
Asp Met Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro Gln 
                85                  90                  95      
Lys Leu Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu Val 
            100                 105                 110         
Thr Thr Asn Phe Gln Thr Lys Ser Gly Gly Ser Thr Cys Val Val His 
        115                 120                 125             
Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp 
    130                 135                 140                 
Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg 
145                 150                 155                 160 
Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys 
                165                 170                 175     
Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Gly Ser 
            180                 185                 190         
Gly Ser Gly Ser Gly Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr 
        195                 200                 205             
Tyr His Val Phe Arg Arg Ile Ser Gly Pro Pro Gly Pro Gly Ser Gly 
    210                 215                 220                 
Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu 
225                 230                 235                 240 
Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro 
                245                 250                 255     
Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser 
            260                 265                 270         
Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys 
        275                 280                 285             
Arg Lys Tyr Met Lys Ser Gly Ser Ser Gly Gly Ser Gly Ser Gly Ile 
    290                 295                 300                 
Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
305                 310                 315                 320 
Glu Gly Gly Ser Met Ser Ser Met Val Ser Asp Thr Ser Cys Thr Phe 
                325                 330                 335     
Pro Ser Ser Asp Gly Thr Phe Trp Lys His Trp Ile Gln Thr Lys Asp 
            340                 345                 350         
Gly Gln Cys Gly Asn Pro Leu Val Ser Thr Arg Asp Gly Phe Ile Val 
        355                 360                 365             
Gly Ile His Ser Ala Ser Asn Phe Thr Asn Thr Asn Asn Tyr Phe Ala 
    370                 375                 380                 
Ser Val Pro Lys Asn Phe Met Glu Leu Leu Thr Asn Gln Glu Ala Gln 
385                 390                 395                 400 
Gln Trp Val Ser Gly Trp Arg Leu Asn Ala Asp Ser Val Leu Trp Gly 
                405                 410                 415     
Gly His Lys Val Phe Met Val Lys Pro Glu Glu Pro Phe Gln Pro Val 
            420                 425                 430         
Lys Glu Ala Thr Gln Leu Met Asn 
        435                 440 

<210> 6
<211> 468
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 6
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Gly Ala Gln Gly Glu Ser Leu Phe Lys Gly Pro Arg 
            20                  25                  30          
Asp Tyr Asn Pro Ile Ser Ser Thr Ile Cys His Leu Thr Gln Glu Ser 
        35                  40                  45              
Asp Gly His Thr Thr Ser Leu Tyr Gly Ile Gly Phe Gly Pro Phe Ile 
    50                  55                  60                  
Ile Thr Asn Lys His Leu Phe Arg Arg Asn Asn Gly Thr Leu Leu Val 
65                  70                  75                  80  
Gln Ser Leu His Gly Val Phe Lys Val Lys Asn Thr Thr Thr Leu Gln 
                85                  90                  95      
Gln His Leu Ile Asp Gly Arg Asp Met Ile Ile Ile Arg Met Pro Lys 
            100                 105                 110         
Asp Phe Pro Pro Phe Pro Gln Lys Leu Lys Phe Arg Glu Pro Gln Arg 
        115                 120                 125             
Glu Glu Arg Ile Cys Leu Val Thr Thr Asn Phe Gln Thr Lys Ser Gly 
    130                 135                 140                 
Gly Ser Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys 
145                 150                 155                 160 
Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu 
                165                 170                 175     
Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met 
            180                 185                 190         
Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr 
        195                 200                 205             
Gly Ala Thr Gly His Gly Ser Gly Ser Gly Ser Gly Val Lys Asp Leu 
    210                 215                 220                 
Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Gly 
225                 230                 235                 240 
Pro Pro Gly Pro Gly Ser Gly Leu Trp His Glu Met Trp His Glu Gly 
                245                 250                 255     
Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly 
            260                 265                 270         
Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro 
        275                 280                 285             
Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu 
    290                 295                 300                 
Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Ser Ser 
305                 310                 315                 320 
Gly Gly Ser Gly Ser Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
                325                 330                 335     
Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Ser Met Ser Ser Met Val 
            340                 345                 350         
Ser Asp Thr Ser Ser Thr Phe Pro Ser Ser Asp Gly Thr Phe Trp Lys 
        355                 360                 365             
His Trp Ile Gln Thr Lys Asp Gly Gln Cys Gly Asn Pro Leu Val Ser 
    370                 375                 380                 
Thr Arg Asp Gly Phe Ile Val Gly Ile His Ser Ala Ser Asn Phe Gly 
385                 390                 395                 400 
Asn Thr Asn Asn Tyr Phe Ala Ser Val Pro Lys Asn Phe Met Glu Leu 
                405                 410                 415     
Leu Thr Asn Gln Glu Ala Gln Gln Trp Val Ser Gly Trp Arg Leu Asn 
            420                 425                 430         
Ala Asp Ser Val Leu Trp Gly Gly His Lys Val Phe Met Ser Lys Pro 
        435                 440                 445             
Glu Glu Pro Phe Gln Pro Val Lys Glu Ala Thr Gln Leu Met Asn Glu 
    450                 455                 460                 
Gly Gly Leu Glu 
465             

<210> 7
<211> 711
<212> DNA
<213> Tobacco etch virus


<400> 7
atgggagaaa gcttgtttaa ggggccgcgt gattacaacc cgatatcgag caccatttgt      60

catttgacga atgaatctga tgggcacaca acatcgttgt atggtattgg atttggtccc     120

ttcatcatta caaacaagca cttgtttaga agaaataatg gaacactgtt ggtccaatca     180

ctacatggtg tattcaaggt caagaacacc acgactttgc aacaacacct cattgatggg     240

agggacatga taattattcg catgcctaag gatttcccac catttcctca aaagctgaaa     300

tttagagagc cacaaaggga agagcgcata tgtcttgtga caaccaactt ccaaactaag     360

agcatgtcta gcatggtgtc agacactagt tgcacattcc cttcatctga tggtatattc     420

tggaagcatt ggattcaaac caaggatggg cagtgtggca gtccattagt atcaactaga     480

gatgggttca ttgttggtat acactcagca tcgaatttca ccaacacaaa caattatttc     540

acaagcgtgc cgaaaaactt catggaattg ttgacaaatc aggaggcgca gcagtgggtt     600

agtggttggc gattaaacgc tgactcagta ttgtgggggg gccataaagt tttcatggtg     660

aaacctgaag aaccttttca gccagttaag gaagcgactc aactcatgaa t              711


<210> 8
<211> 786
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 8
atgggctgga gcctgatcct cctgttcctc gtcgctgtgg ctacaggtgt gcactctcag      60

atgggggaaa gcctgttcaa gggaccaagg gactacaatc caatctcctc aactatctgc     120

cacctgactc aggaaagcga cggacatacc acatctctgt acggaattgg cttcgggccc     180

ttcatcatta ctaacaagca cctgtttcgg agaaacaatg gcaccctgct ggtgcagagt     240

ctgcacgggg tgttcaaggt caaaaatact accacactgc agcagcatct gattgacgga     300

cgagatatga tcattatccg gatgccaaag gacttccccc cttttcccca gaagctgaag     360

ttccgggagc cccagaggga ggaacgcatc tgcctggtga ctaccaactt ccagaccaaa     420

tccatgagct ccatggtctc cgacacctct tctacattcc cttctagtga tggcatcttc     480

tggaagcact ggatccagac aaaagacgga cagtgcggca gtccactggt gtcaaccaga     540

gatgggttta ttgtcggaat ccattcagcc agcaacttcg gaaatactaa caattacttc     600

acctctgtgc ccaaaaactt catggagctg ctgactaatc aggaagcaca gcagtgggtg     660

agcggatggc gcctgaatgc tgattccgtg ctgtggggcg ggcataaggt cttcatgagc     720

aaacctgaag agccatttca gcccgtcaag gaagccaccc agctgatgaa cgaagggggc     780

ctggaa                                                                786


<210> 9
<211> 1323
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 9
atgggagaaa gcttgtttaa ggggccgcgt gattacaacc cgatatcgag caccatttgt      60

catttgacga atgaatctga tgggcacaca acatcgttgt atggtattgg atttggtccc     120

ttcatcatta caaacaagca cttgtttaga agaaataatg gaacactgtt ggtccaatca     180

ctacatggtg tattcaaggt caagaacacc acgactttgc aacaacacct cattgatggg     240

agggacatga taattattcg catgcctaag gatttcccac catttcctca aaagctgaaa     300

tttagagagc cacaaaggga agagcgcata tgtcttgtga caaccaactt ccaaactaag     360

agcggtggat caacctgcgt ggtgcactac accgggatgc ttgaagatgg aaagaaattt     420

gattcctccc gggacagaaa caagcccttt aagtttatgc taggcaagca ggaggtgatc     480

cgaggctggg aagaaggggt tgcccagatg agtgtgggtc agagagccaa actgactata     540

tctccagatt atgcctatgg tgccactggg cacggttcgg gctccggatc aggcgtcaag     600

gacctcctcc aagcctggga cctctattat catgtgttcc gacgaatctc aggtcctcca     660

ggacctggat caggtctctg gcatgagatg tggcatgaag gcctggaaga ggcatctcgt     720

ttgtactttg gggaaaggaa cgtgaaaggc atgtttgagg tgctggagcc cttgcatgct     780

atgatggaac ggggccccca gactctgaag gaaacatcct ttaatcaggc ctatggtcga     840

gatttaatgg aggcccaaga gtggtgcagg aagtacatga aatcagggtc atcagggggc     900

tccggatcag gcatcatccc accacatgcc actctcgtct tcgatgtgga gcttctaaaa     960

ctggaaggtg gatcaatgtc tagcatggtg tcagacacta gttgcacatt cccttcatct    1020

gatggtacgt tctggaagca ttggattcaa accaaggatg ggcagtgtgg caatccatta    1080

gtatcaacta gagatgggtt cattgttggt atacactcag catcgaattt caccaacaca    1140

aacaattatt tcgcaagcgt gccgaaaaac ttcatggaat tgttgacaaa tcaggaggcg    1200

cagcagtggg ttagtggttg gcgattaaac gctgactcag tattgtgggg gggccataaa    1260

gttttcatgg tgaaacctga agaacctttt cagccagtta aggaagcgac tcaactcatg    1320

aat                                                                  1323


<210> 10
<211> 1404
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 10
atgggctgga gcctgatcct cctgttcctc gtcgctgtgg ctacaggtgt gcactctcag      60

ggcgcgcaag gggaaagcct gttcaaggga ccaagggact acaatccaat ctcctcaact     120

atctgccacc tgactcagga aagcgacgga cataccacat ctctgtacgg aattggcttc     180

gggcccttca tcattactaa caagcacctg tttcggagaa acaatggcac cctgctggtg     240

cagagtctgc acggggtgtt caaggtcaaa aatactacca cactgcagca gcatctgatt     300

gacggacgag atatgatcat tatccggatg ccaaaggact tccccccttt tccccagaag     360

ctgaagttcc gggagcccca gagggaggaa cgcatctgcc tggtgactac caacttccag     420

accaaatccg gtggatcaac ctgcgtggtg cactacaccg ggatgcttga agatggaaag     480

aaatttgatt cctcccggga cagaaacaag ccctttaagt ttatgctagg caagcaggag     540

gtgatccgag gctgggaaga aggggttgcc cagatgagtg tgggtcagag agccaaactg     600

actatatctc cagattatgc ctatggtgcc actgggcacg gttcgggctc cggatcaggc     660

gtcaaggacc tcctccaagc ctgggacctc tattatcatg tgttccgacg aatctcaggt     720

cctccaggac ctggatcagg tctctggcat gagatgtggc atgaaggcct ggaagaggca     780

tctcgtttgt actttgggga aaggaacgtg aaaggcatgt ttgaggtgct ggagcccttg     840

catgctatga tggaacgggg cccccagact ctgaaggaaa catcctttaa tcaggcctat     900

ggtcgagatt taatggaggc ccaagagtgg tgcaggaagt acatgaaatc agggtcatca     960

gggggctccg gatcaggcat catcccacca catgccactc tcgtcttcga tgtggagctt    1020

ctaaaactgg aaggtggatc aatgagctcc atggtctccg acacctcttc tacattccct    1080

tctagtgatg gcaccttctg gaagcactgg atccagacaa aagacggaca gtgcggcaat    1140

ccactggtgt caaccagaga tgggtttatt gtcggaatcc attcagccag caacttcgga    1200

aatactaaca attacttcgc ctctgtgccc aaaaacttca tggagctgct gactaatcag    1260

gaagcacagc agtgggtgag cggatggcgc ctgaatgctg attccgtgct gtggggcggg    1320

cataaggtct tcatgagcaa acctgaagag ccatttcagc ccgtcaagga agccacccag    1380

ctgatgaacg aagggggcct ggaa                                           1404


<210> 11
<211> 19
<212> PRT
<213> Homo sapiens


<400> 11
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      
Val His Ser 
            

<210> 12
<211> 6
<212> PRT
<213> Tobacco etch virus


<400> 12
Glu Asn Leu Tyr Phe Gln 
1               5       

<210> 13
<211> 43
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 13
ccaatgcttc cagaacgtac catcagatga agggaatgtg caa                       43


<210> 14
<211> 43
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 14
ttgcacattc ccttcatctg atggtacgtt ctggaagcat tgg                       43


<210> 15
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 15
ttgatactaa tggattgcca cactgcccat ccttg                                35


<210> 16
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 16
caaggatggg cagtgtggca atccattagt atcaa                                35


<210> 17
<211> 42
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 17
gtttttcggc acgcttgcga aataattgtt tgtgttggtg aa                        42


<210> 18
<211> 42
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 18
ttcaccaaca caaacaatta tttcgcaagc gtgccgaaaa ac                        42


<210> 19
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 19
ccagtgcttc cagaaggtgc catcactaga agg                                  33


<210> 20
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 20
ccttctagtg atggcacctt ctggaagcac tgg                                  33


<210> 21
<211> 29
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 21
gacaccagtg gattgccgca ctgtccgtc                                      29


<210> 22
<211> 29
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 22
gacggacagt gcggcaatcc actggtgtc                                      29


<210> 23
<211> 41
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 23
gtttttgggc acagaggcga agtaattgtt agtatttccg a                         41


<210> 24
<211> 41
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 24
tcggaaatac taacaattac ttcgcctctg tgcccaaaaa c                         41


<210> 25
<211> 45
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 25
gggtcagagt ggcgccggag attctcggac atgtttgcag catct                     45


<210> 26
<211> 45
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 26
agatgctgca aacatgtccg agaatctccg gcgccactct gaccc                     45


<210> 27
<211> 51
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 27
ccctcggcgg gcagggtcag actggaaata gagattctcg gacatgtttg c              51


<210> 28
<211> 51
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 28
gcaaacatgt ccgagaatct ctatttccag tctgaccctg cccgccgagg g              51


<210> 29
<211> 38
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 29
caacttccaa actaagagcg gtggatcaac ctgcgtgg                             38


<210> 30
<211> 44
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 30
tgacaccatg ctagacattg atccaccttc cagttttaga agct                      44


<210> 31
<211> 26
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 31
atgtctagca tggtgtcaga cactag                                         26


<210> 32
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 32
gctcttagtt tggaagttgg ttgt                                           24


<210> 33
<211> 52
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 33
ccaacttcca gaccaaatcc ggtggatcaa cctgcgtggt gcactacacc gg             52


<210> 34
<211> 44
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 34
tgacaccatg ctagacattg atccaccttc cagttttaga agct                      44


<210> 35
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 35
atgagctcca tggtctccga cac                                            23


<210> 36
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Artificial Sequence

<400> 36
ggatttggtc tggaagttgg tag                                            23


